10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ C_elegans_Y56A3A.32.1 M---------------------------------------------------------------------------L------------LRA-------------------------VGR T_rubripes_ENSTRUP00000030183 M---------------------------------------------------------------------------LKC-----------RS-------------------------VWR T_nigroviridis_ENSTNIP00000014785 M---------------------------------------------------------------------------LQC-----------RT-------------------------VWT C_intestinalis_ENSCINP00000012225 M---------------------------------------------------------------------------FRCVRLCEHSSSISRS-------------------------LLN O_latipes_ENSORLP00000012070 M---------------------------------------------------------------------------LKC-----------RT-------------------------VWR H_sapiens_ENSP00000287295 M---------------------------------------------------------------------------FRCGGLAAGA-------------------------------LKQ X_tropicalis_ENSXETP00000039440 M---------------------------------------------------------------------------ALCRVS-----------------------------------VLG T_guttata_ENSTGUP00000005365 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000023188 M---------------------------------------------------------------------------FRCGGLAAGA-------------------------------LKQ E_caballus_ENSECAP00000002768 M---------------------------------------------------------------------------FRCGGLAAGA-------------------------------LKQ A_carolinensis_ENSACAP00000008812 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000006568 M---------------------------------------------------------------------------FRCGGLAAGA-------------------------------LKQ G_aculeatus_ENSGACP00000026857 M---------------------------------------------------------------------------LKC-----------RT-------------------------VWR D_rerio_ENSDARP00000075330 M---------------------------------------------------------------------------FKC-----------KT-------------------------VWN R_norvegicus_ENSRNOP00000008503 M---------------------------------------------------------------------------FRCGGL-AGA-------------------------------FKQ M_musculus_ENSMUSP00000041104 M---------------------------------------------------------------------------FRCGGL-AGA-------------------------------FKQ B_taurus_ENSBTAP00000008987 M---------------------------------------------------------------------------FRCGGLAAGA-------------------------------LKQ C_familiaris_ENSCAFP00000027660 M---------------------------------------------------------------------------FRCGSLAAGA-------------------------------FKQ A_gambiae_AGAP008044-PA M---------------------------------------------------------------------------LSVSRVAVGNVRCVQP--ALVRIRKHVLAGGFTQTFGSRRWISV G_gallus_ENSGALP00000006366 M----------------------------------------------------------------------------------------------------------------------- A_aegypti_AAEL002016-PA M---------------------------------------------------------------------------LAVSRAAISNLRIAQPRVATIRARKQFAGGSFC----SRRWFTK D_melanogaster_FBpp0077504 M---------------------------------------------------------------------------SIWGVRCLTQRFIRQA----------YILANRRLLGPVPQRSPP M_domestica_ENSMODP00000027578 M---------------------------------------------------------------------------LRWGSAAATG-------------------------------LGQ O_cuniculus_ENSOCUP00000002538 M---------------------------------------------------------------------------FRCGGLAAGA-------------------------------LKQ P_troglodytes_ENSPTRP00000038338 M---------------------------------------------------------------------------FRCGGLAAGA-------------------------------LKQ T_guttata_ENSTGUP00000016816 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000007470 M---------------------------------------------------------------------------FRCGGLAAGA-------------------------------LKQ C_intestinalis_ENSCINP00000015763 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000085557 M----------------------------------------------------------GGCLSKPKPVEVKVELTLLDKEKEVDLMSPNGKASPFSECRPNGSLGHCSDEDSMTLRPQR O_latipes_ENSORLP00000009976 M----------------------------------------------------------GGCFSKPKAVEVKVELSLLEKEKDLDGLSPNGKASPFADCRPNGALGHGSEDDSSLLPLNF G_gallus_ENSGALP00000012503 M----------------------------------------------------------GGCFSKPKPVEVKIEVVIPEKERSKEEMSPNGKASPLVYKVNGTARHYHLEEHPIASNPYH P_pygmaeus_ENSPPYP00000013415 M----------------------------------------------------------GGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRAYQGNGTARHFHTEERLSTPHPYP T_guttata_ENSTGUP00000010972 M----------------------------------------------------------GGCFSKPKPVEVKIEVVIPEKERSKEEMSPNGKASPLIYKVNGTARHYHLEEHPIASNPYH P_troglodytes_ENSPTRP00000024275 M----------------------------------------------------------GGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRAYQGNGTARHFHTEERLSTPHPYP H_sapiens_ENSP00000382120 M----------------------------------------------------------GGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRAYQGNGTARHFHTEERLSTPHPYP G_aculeatus_ENSGACP00000012379 M----------------------------------------------------------GGCFSKPKPVEVKVELSLLEKEKDVDGLSPNGKASPFADCRPNGALGHGSDDDSTPPPLYH B_taurus_ENSBTAP00000053272 M----------------------------------------------------------GGCFSKPKPVELKIEVVLPEKDRGKEELSTGSRGSPRAYQGNGAARHFHADERLPTAHPYP M_mulatta_ENSMMUP00000026974 M----------------------------------------------------------GGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRAYQGNGTARHFHTEERLPTPHPYP T_nigroviridis_ENSTNIP00000019217 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000018986 --------------------------------------------------------------------VEVKVELSLLDKEKEMEGLSPNGKASPFADCRPNGALGHGSDDDATPLVLYH R_norvegicus_ENSRNOP00000048427 M----------------------------------------------------------GGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRGYQGNGTARHFHAEERLPTPQPYP A_carolinensis_ENSACAP00000010903 M----------------------------------------------------------GSCFSKSKPVEVKIEVVLPEKERAKEEMSPNGKASPIIYKANGTSRHYQLEEHPVALNPYR T_rubripes_ENSTRUP00000040932 M----------------------------------------------------------GGCFSKPKPVEVKVELSLLDKEKEMDGLSPNGKASPFADCRPNGALGHGSDDDSTPLALYH M_musculus_ENSMUSP00000111349 M----------------------------------------------------------GGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRGYQGNGTARHFHAEERLPTPQPYP O_latipes_ENSORLP00000010037 M--------------------------------------------------------------------------------------------------------------SELQDAGQR T_nigroviridis_ENSTNIP00000021125 --------------------------------------------------------------------------------------------------------------------NQQV G_aculeatus_ENSGACP00000011210 M----------------------------------------------------------------------------------------------------------NRCKGPGQGAEEQ T_rubripes_ENSTRUP00000040612 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000027082 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000057179 M----------------------------------------------------------GGCFSKPKPVEVKVEVVLPEKEREKEEMSPNGKASPLAYKANGTTRLYHHEERPIVLNPYT G_gallus_ENSGALP00000039047 ---------------------------------------------------------------------------------------------------------------RPLPVSINM O_latipes_ENSORLP00000003241 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000014484 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000030429 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0080714 M----------------------------------------------------------------------------------------------------------------------- A_aegypti_AAEL011158-PA M---------------------------------------------------------LRAALQISNRLVIPARSRGNDSRKMMSLLSKVTG-------------------------GAS D_melanogaster_FBpp0070319 MLDWPFCLSVSKVGGLQIRKKWQSPRTALSLVKTKRAFEGLLRIRKLPSSQSWRILNAPSFASHINNRLLNTMGSVNCKEYKTTGSTPKKEKSTGGAVGSYQSKCSNQSPSTTMSTEESS C_elegans_F20D6.11 M--------------------------------------------------------------------------------------------------------ALANWLTPVEPECDN 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ C_elegans_Y56A3A.32.1 QMTSVIFRQQTAVRSIAMSRVAL---------------------------------------------------------------------------GGGGHHHEPTPV-YIPKPGSLD T_rubripes_ENSTRUP00000030183 RLAPLARASSTVC----RQNARR---------------------------------------------------------------------------TG--LNNARIPV-----REPA- T_nigroviridis_ENSTNIP00000014785 RLAPLARASSTVC----RQNVRR---------------------------------------------------------------------------TG--LNNAKTPT-----CAPA- C_intestinalis_ENSCINP00000012225 KNAPKTQAVIVSR-----------------------------------------------------------------------------------------YQDQVTPV-----HCKQN O_latipes_ENSORLP00000012070 KLAPLAKSSSTLC----RQNVRR---------------------------------------------------------------------------AG--LNNGRTPV-----CVPA- H_sapiens_ENSP00000287295 KLVPLVR---TVCVRSPRQRNRL---------------------------------------------------------------------------PGNLFQRWHVPL-----ELQM- X_tropicalis_ENSXETP00000039440 LRAARGGNQISQRLRLRSTEKRV---------------------------------------------------------------------------AGDFLHQQSLLP-----HQTF- T_guttata_ENSTGUP00000005365 ---------------------------------------------------------------------------------------------------GTLLQRWNVPP-----DLQL- P_pygmaeus_ENSPPYP00000023188 KLVPLVR---TVCVRSPRQRNRL---------------------------------------------------------------------------PGNLFQRWHVPL-----ELQM- E_caballus_ENSECAP00000002768 KLAPLVR---TVCVRGPRQRNRL---------------------------------------------------------------------------PGNLFQRWHVPL-----ELQM- A_carolinensis_ENSACAP00000008812 --------------------------------------------------------------------------------------------------PGLLCQRWKVPL-----EVQL- M_mulatta_ENSMMUP00000006568 KLVPLVR---TVCVRSPRQRNRL---------------------------------------------------------------------------PGNLFQRWHVPL-----ELQM- G_aculeatus_ENSGACP00000026857 TLAPLARTSSTVC----RQNARR---------------------------------------------------------------------------AG--LNNGRLPA-----CVPA- D_rerio_ENSDARP00000075330 KLAPLARASSTLCLQNARKSVLR---------------------------------------------------------------------------HGRRLE-------------MV- R_norvegicus_ENSRNOP00000008503 KLVPLVR---SVCVQRPKQRNRL---------------------------------------------------------------------------PGNLFQQWRVPL-----ELQM- M_musculus_ENSMUSP00000041104 KLVPLVR---TVYVQRPKQRNRL---------------------------------------------------------------------------PGNLFQQWRVPL-----ELQM- B_taurus_ENSBTAP00000008987 KLAPLVR---TVCVRGPRQRNRL---------------------------------------------------------------------------PGNLFQRWHVPL-----ELQM- C_familiaris_ENSCAFP00000027660 KLAPLVR---TVCVRGPRQRNRL---------------------------------------------------------------------------PGNLFQRWHVPL-----ELQM- A_gambiae_AGAP008044-PA KVNQALLAKEAEPNRRRRQTLKEREAESNEPCSCVEEEGPNSSTIVTPCDESRRLPMMGELIQFPNDPS-----------------------------PYPAPPRRHIPI-----NRFFQ G_gallus_ENSGALP00000006366 -----------SCCRLAAAALR----------------------------------------------------------------------------PLSSVQRGRAAA-----VLQCH A_aegypti_AAEL002016-PA KVNDLITRQVTER---RRRLLEASGACQSPPYPGCSSERTKPSQ--YGCIDPDRTPMIGEDIQFPGGVQDQSREEV-------------------VQMPPKTRPKRSAPE---------- D_melanogaster_FBpp0077504 AYAPLRPAHSSLYQMVKKRTLEARTKLQANKYPNHQVCVTKPST--TPPVEEYETAVEGAGVPAYANAQFQAHSQSEPLFKVGFADVKSVCSAKDVLKSDSAKLSTSQPVLDSCKATSPC M_domestica_ENSMODP00000027578 KLVPLVQ---TICVRGQKQKSRF---------------------------------------------------------------------------PGNLLQRWHIPV-----EFQM- O_cuniculus_ENSOCUP00000002538 KLVPLVR---TVCVRSPRQRNRL---------------------------------------------------------------------------PGNLFQRWHVPL-----ELQM- P_troglodytes_ENSPTRP00000038338 KLVPLVR---TVCVRSPRQRNRL---------------------------------------------------------------------------PGNLFQRWHVPL-----ELQM- T_guttata_ENSTGUP00000016816 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000007470 KLVPLVR---TVCVRSPRQRNRL---------------------------------------------------------------------------PXXXXXXXXXXX-----XXXX- C_intestinalis_ENSCINP00000015763 SKDEIVE--AYAC-------------------------------------------------------------------------------------KVGEMKDGEMREVSVGD-GKAL D_rerio_ENSDARP00000085557 KNRDYIE--ASVC-------------------------------------------------------------------------------------HIKDLENGQMREVDLGA-GRAL O_latipes_ENSORLP00000009976 KTRDYVE--ACVC-------------------------------------------------------------------------------------HIKDLENGQMREVDLGS-GRAL G_gallus_ENSGALP00000012503 NPKDVVE--ASVC-------------------------------------------------------------------------------------HVKDLENGQMREVDLGC-GKAL P_pygmaeus_ENSPPYP00000013415 SPQDCVE--AAVC-------------------------------------------------------------------------------------HVKDLENGQMREVELGW-GKVL T_guttata_ENSTGUP00000010972 NPKDVVE--ASVC-------------------------------------------------------------------------------------HVKDLENGQMREVDLGC-GKAL P_troglodytes_ENSPTRP00000024275 SPQDCVE--AAVC-------------------------------------------------------------------------------------HVKDLENGQMREVELGW-GKVL H_sapiens_ENSP00000382120 SPQDCVE--AAVC-------------------------------------------------------------------------------------HVKDLENGQMREVELGW-GKVL G_aculeatus_ENSGACP00000012379 KARDYVE--ASVC-------------------------------------------------------------------------------------HVKDLENGQMREVDLGS-GRAL B_taurus_ENSBTAP00000053272 GAQDCVE--AAVC-------------------------------------------------------------------------------------HVKDLENGQMREVELGW-GKVL M_mulatta_ENSMMUP00000026974 SPQDCVE--AAVC-------------------------------------------------------------------------------------HVKDLENGQMREVELGW-GKVL T_nigroviridis_ENSTNIP00000019217 ----------AVC-------------------------------------------------------------------------------------LESELQDGQMMEVEVGH-HSVL T_nigroviridis_ENSTNIP00000018986 KPREYVE--ASVC-------------------------------------------------------------------------------------HVKDLENEQMREVDLGS-GRAL R_norvegicus_ENSRNOP00000048427 SPQDCVE--ATVC-------------------------------------------------------------------------------------HVKDLENGQMREVELGW-GKVL A_carolinensis_ENSACAP00000010903 NLKDVVE--ASVC-------------------------------------------------------------------------------------YVKDLDNGQMREVDLGC-GKAL T_rubripes_ENSTRUP00000040932 KPREYVE--VSVC-------------------------------------------------------------------------------------HVKDLENEQMREVDLGS-GRAL M_musculus_ENSMUSP00000111349 SPQDCVE--ATVC-------------------------------------------------------------------------------------HVKDLENGQMREVELGW-GKVL O_latipes_ENSORLP00000010037 GEQEEVT--ELVC-------------------------------------------------------------------------------------PEADLHDGQMKEVTVQD-QKVL T_nigroviridis_ENSTNIP00000021125 QEEDELT--EMVC-------------------------------------------------------------------------------------QESELKDGQMKEVTVGE-KKVL G_aculeatus_ENSGACP00000011210 QEEEEVT--GMVC-------------------------------------------------------------------------------------QEVDLRDGQMKEVTVGD-QKVL T_rubripes_ENSTRUP00000040612 --EDELT--EMVC-------------------------------------------------------------------------------------QETDLKDGQMKEVMVGE-KKVL G_aculeatus_ENSGACP00000027082 -----------VC-------------------------------------------------------------------------------------LESDLQDGQMMEVEVGQ-HSVL X_tropicalis_ENSXETP00000057179 NPKDVVE--ASVC-------------------------------------------------------------------------------------HVKDLENGQMREVDLGC-GKAL G_gallus_ENSGALP00000039047 DCNDTVT--AEVC-------------------------------------------------------------------------------------REDDIGDGELCEVMVAG-YPVL O_latipes_ENSORLP00000003241 ----------------------------------------------------------------------------------------------------------RMKEVEIGH-HSVL A_carolinensis_ENSACAP00000014484 -----------------------------------------------------------------------------------------------------------MREVDVAG-WPVV T_rubripes_ENSTRUP00000030429 ----------AVC-------------------------------------------------------------------------------------LESELQEGQMMEVEVGH-HSVL D_melanogaster_FBpp0080714 EENEYIDP-VVVC-------------------------------------------------------------------------------------HKLEVQENEMRQVDASGIPSIL A_aegypti_AAEL011158-PA PDGGYVE--DFIC-------------------------------------------------------------------------------------NENDIGENEMKAFEVDG-GKVL D_melanogaster_FBpp0070319 PDSEYTSAVPVDC-------------------------------------------------------------------------------------RVTDLKENEMKQVDFDEDTRVL C_elegans_F20D6.11 DDSPAVE--EILG-------------------------------------------------------------------------------------RIEDVPPGTKKMFEVRD-RKVL 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ C_elegans_Y56A3A.32.1 WTFFSRSHTKSAHEFEPYKPEIGA-FIGAVA-----FIGLTLIAVVIKTDVFKKEDSHGHGHGHAKHSKKHEEKHEQKHEEKEHAEPEKKEEAKPEKPAEPKEPEPAQKQAEQ------- T_rubripes_ENSTRUP00000030183 -------VHMSTG-------PTGG--GGREN---------LLYFAMVGTTFI------GAG-IYVYRTLKEDKERYQDRINEIASRPQKAAAKEAT-------------------LLHPE T_nigroviridis_ENSTNIP00000014785 -------ARMSTG-------STGG-GEGREN---------LLYFAVIGTTCV------GAG-IYVYRTLKQDKERYQDRINVIASRPKKAAVNEAT-------------------VPQPE C_intestinalis_ENSCINP00000012225 RAFYSQKATFHSDQSSNYG---------------------SGFCIIGGTLFF------GIG---IYKYLTESKANAAEARTQ-------------------------------------- O_latipes_ENSORLP00000012070 -------AHMSSG-------PVGG---GGDN---------LKYALLVGAVSV------GGL-VYAVVTMKSDQKRYEQRIEELSTRPQKTSTIPTA------AQIQSEPPVKETALVQAV H_sapiens_ENSP00000287295 -----TRQMASSG-------ASGG---KIDN---------SVLVLIVGLSTV------GAG-AYAYKTMKEDEKRYNERISGLGLTPEQKQKKAAL------------------------ X_tropicalis_ENSXETP00000039440 -----RNAGGPAG-------VPGP---GGDS---------SLYALIVGVSAL------GAG-IYVYRTLQGDKARFRERNSYLSRRQTDLKEEVKATETIDEQK---------------- T_guttata_ENSTGUP00000005365 -----SRQVASKG-------VPGQ---KGSN---------SVFVLIMGLSTL------GAG-AYVYKTLQDSKERYASRLAR---TSRQSQDSAAP------------------------ P_pygmaeus_ENSPPYP00000023188 -----TRQMASSG-------ASGG---KIDN---------SVLVLIVGLSTV------GAG-AYVSRKAACIKKLPNRESS--ETSRRFIQSVLLL------------------------ E_caballus_ENSECAP00000002768 -----TRQMASSG-------ASGG---KIDN---------SVLVLFVGLSTI------GAG-AYAYKTIKDDKKRYNERISGLGLTPEEKQKRATS------------------------ A_carolinensis_ENSACAP00000008812 -----SRHMASSG-------APGG---KSEN---------IVFALLVGFSTL------GAG-AYVYKTLKEDKERYNERIASLGQRPSQDAEPSAA------------------------ M_mulatta_ENSMMUP00000006568 -----TRQMASSG-------ASGG---KIDN---------SVLVLIVGLSTV------GAG-VYAYKIIKEDEKRYNERISGLGLTPEQKQKKAAL------------------------ G_aculeatus_ENSGACP00000026857 -------AHMSTA-------PAGG---GREN---------QLYVLLVGATCV------GGA-IYAYRTVKGDSQRYQDRIDEISSRPLKTFTEEPA----------------------TP D_rerio_ENSDARP00000075330 -----QRAQMSSG-------PPGG---GGEN---------AVYFVLVGAACL------GGG-IYAYRTVSQDSERYNERMRQIASRQSQESKPAKALAEVAESKEELEPVAEEPTLIEPA R_norvegicus_ENSRNOP00000008503 -----ARQMASSG-------PSGG---KMDN---------SVLVLIVGLSTI------GAG-AYAYKTIKEDQKRYNERIMGLGLSPEEKQRRAIA------------------------ M_musculus_ENSMUSP00000041104 -----ARQMASSG-------SSGG---KMDN---------SVLVLIVGLSTI------GAG-AYAYKTIKEDQKRYNERVMGLGLSPEEKQRRAIA------------------------ B_taurus_ENSBTAP00000008987 -----TRQMASSG-------PSGG---KIDN---------SVLVLIVGLSTI------GAG-AYAYKTIKDDKKRYNERISGLGLTPEEKQKRATS------------------------ C_familiaris_ENSCAFP00000027660 -----ARQMASSG-------ASGG---KIDN---------SVLVLIVGLSTI------GAG-AYAYKTIKDDQKRYDERMSGLGLTPEEKQKRATS------------------------ A_gambiae_AGAP008044-PA QTEQKAIAATGGPTCPPPPPPPPK---PSYT---------GYILGAIALTAG------GLGLAYYNGLFDGPPPP--TPVDDTKEDADRKKRT--------------------------- G_gallus_ENSGALP00000006366 HLRYPSRALTSSG-------VPGK---AGSN---------LLLYLIVGGTVT------GAG-AYVYKTLRENKERFTSRVTTVTTRSQEKESSPSA------------------------ A_aegypti_AAEL002016-PA -REESLSAKASAPAC-PPPPPPGQ---NSTN---------SYIFGAIALTAG------GLGLAYAMGLFDGKESPMVEKAEPTVAEQPKKKTKLP------------------------- D_melanogaster_FBpp0077504 EEFKRKRKETTCQPCDEDGTAPGG-GDGGDEECECRMKDLRLKCLLGALAAL------LAG-GFLAWFMTRDTDDSEAKKAE--AEEEERKRRLVA------------------------ M_domestica_ENSMODP00000027578 -----TRQMASSG-------ASGN---KIDK---------SMLVLIVGLSSM------GAG-AYAYMTVKEDQKRYDERISGLGLTPEEKERRDSL------------------------ O_cuniculus_ENSOCUP00000002538 -----TRQMASSG-------ASGG---KIDN---------SVLVLIVGLSTI------GAG-AYAYKTIKDDKKRYDERMSGLGLTPEEKQKRATA------------------------ P_troglodytes_ENSPTRP00000038338 -----TRQMASSG-------ASGG---KIDN---------SVLVLIVGLSTV------GAG-AYAYKTMKEDEKRYNERISGLGLTPEQKQKKAAL------------------------ T_guttata_ENSTGUP00000016816 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000007470 -----XXXXXXXX-------XXXX---XXXX---------XXXXXXXXXSTV------GAG-AYXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX------------------------ C_intestinalis_ENSCINP00000015763 LVRHQGEYSAIGHKCTHYGAPLVK-GALRDGRVRCPWHGACFNAKTGDIEDFP-----GLDCVPKHNIVIQDGDKVVIRACKSALETHKRYK---------------------------- D_rerio_ENSDARP00000085557 LIKEHGEFFAMGHKCPHYGAPLVK-GVLSKGHVRCPWHGACFNIATGDIEDFP-----GLDSLPTFQVRVEK-EKVIIRANKQALQTQRRSK---------------------------- O_latipes_ENSORLP00000009976 LIKEHGEFFAMGHKCPHYGAPLVK-GVLSKGHVRCPWHGACFNVATGDIEDFP-----GLDSLPVFQVRVEK-EKVIIRANKQALQTQKRSK---------------------------- G_gallus_ENSGALP00000012503 LIKEGGEFYAMGHKCPHYGAPLVK-GVLSKGRVRCPWHGACFNIGTGDIEDFP-----GLDSLPRFQVKIEK-EKVYIRASKQALQTQRRTK---------------------------- P_pygmaeus_ENSPPYP00000013415 LVKDNGEFHALGHKCPHYGAPLVK-GVLSRGRVRCPWHGACFNISTGDLEDFP-----GLDSLHKFQVKIEK-EKVYVRASKQALQLQRRTK---------------------------- T_guttata_ENSTGUP00000010972 LIKESGEFHAVGHKCPHYGAPLVK-GVLSKGRVRCPWHGACFNISTGDIEDFP-----GLDSLPRFQVKIEK-EKVYIRASKQTLQTQRRTK---------------------------- P_troglodytes_ENSPTRP00000024275 LVKDNGEFHALGHKCPHYGAPLVK-GVLSRGRVRCPWHGACFNISTGDLEDFP-----GLDSLHKFQVKIEK-EKVYVRASKQALQLQRRTK---------------------------- H_sapiens_ENSP00000382120 LVKDNGEFHALGHKCPHYGAPLVK-GVLSRGRVRCPWHGACFNISTGDLEDFP-----GLDSLHKFQVKIEK-EKVYVRASKQALQLQRRTK---------------------------- G_aculeatus_ENSGACP00000012379 LIKEHGEFSAMAHKCPHYGAPLVK-GVLSKGHVRCPWHGACFDIATGDLEDFP-----GLDSLPTFQVRVEK-DKVIIRANKQALQSQKRSK---------------------------- B_taurus_ENSBTAP00000053272 LVKDNGELHALGHKCPHYGAPLVK-GVLSRGRVRCPWHGACFNVSTGDLEDFP-----GLDSLHKFQVKIEK-EKVYIRASKQALQLQRRTK---------------------------- M_mulatta_ENSMMUP00000026974 LVKDNGEFHALGHKCPHYGAPLVK-GVLSRGRVRCPWHGACFNISTGDLEDFP-----GLDSLHKFQVKIEK-EKVYVRASKQALQLQRRTK---------------------------- T_nigroviridis_ENSTNIP00000019217 LTHCEGKFSAIGNQCTHYGAPLSKAGAITGHTVRCPWHGACFNVHTGDLEEYP-----GIDSLPCHKVRIHN-SQVYVSVNKKTLRQEKRIK---------------------------- T_nigroviridis_ENSTNIP00000018986 LIKQRGEFSAIGHKCPHYGAPLVK-GVLSKGHVRCPWHGACFNIATGDIEDFP-----GLDSLPTFQVRVEK-DKVIIRANKQALQAQRRSK---------------------------- R_norvegicus_ENSRNOP00000048427 LVKDNGEFHALGHKCPHYGAPLVK-GVLSRGRVRCPWHGACFNIGTGDLEDFP-----GLDSLHKFQVKIEK-EKVTVRASKQALQLQRRTK---------------------------- A_carolinensis_ENSACAP00000010903 LVKENGEFYAMGHKCPHYGAPLVK-GVLSKGRIRCPWHGACFNIGTGDIEDFP-----GLDSLPKFQVKIEK-EKVYIRASKQALQTQRRTK---------------------------- T_rubripes_ENSTRUP00000040932 LIKQRGEFSAIGHKCPHYGAPLVK-GVLSKGHVRCPWHGACFNIATGDIEDFP-----GLDSLPTFQVRVEK-DKVIIRANKQALQSQRRSK---------------------------- M_musculus_ENSMUSP00000111349 LVKDNGEFHALGHKCPHYGAPLVK-GVLSRGRVRCPWHGACFNISTGDLEDFP-----GLDSLHKFQVKIEK-EKVTIRASKQALQLQRRTK---------------------------- O_latipes_ENSORLP00000010037 VVRTQGQYFAVGGRCSHYNAPLIK-GALVGERVRCPFHGACFNVRTGDIEDYP-----GLDSLPTYKVKVED-GKVYVSINQKSLKLTKRVK---------------------------- T_nigroviridis_ENSTNIP00000021125 LVCSQGRYSAVGSQCSHYNAPLVK-GALFGERVRCPFHGACFNVRTGDIEEYP-----GLDSLPSYKVKVEN-GMVYVTVQKHSLKLTKRVK---------------------------- G_aculeatus_ENSGACP00000011210 LVRTRGQYSAVGSQCSHYNAPLVK-GVLVGDRVRCPFHGACFNVRTGDIEEYP-----GLDCLPSYKVKVED-GKVYVSIHKNSLKLTKRVK---------------------------- T_rubripes_ENSTRUP00000040612 LVCSQGQYSAIGSQCSHYNAPLVK-GTLVGQRVRCPFHGACFNVRTGDIEEYP-----GLDSLPTYKVKVEN-GMVYVTVNKHALKLTKRVK---------------------------- G_aculeatus_ENSGACP00000027082 LSRTEGEYSAIGNQCTHYGAPLSQAGVISGNTVRCPWHGACFNIHTGDLEEYP-----GMDCLPCHKVKIQN-NKVYVSVNKKTLKQEKRVK---------------------------- X_tropicalis_ENSXETP00000057179 LVKQNGEYYAMGHKCPHYGAPLVK-GVLSKGRVRCPWHGACFNIATGDIEDFP-----GLDALPKFQVKIEK-ERVYIRASKQSLHTMHWDK---------------------------- G_gallus_ENSGALP00000039047 LVRDKMEFSALGSRCPHYGAPLSK-GVLRGHRLRCPWHGSCFNIKTGDIEEYP-----SLDCLPCFKVTVED-GKVFVTAKKKDLESSLRVK---------------------------- O_latipes_ENSORLP00000003241 LTRHEGKYSALGNQCTHYGAPLSQ-GVVSGNRVRCPWHGSCFNICTGDLEEFP-----GIDSLPCHKVKIQN-SKVYVTVNRKDLKQQKRIR---------------------------- A_carolinensis_ENSACAP00000014484 LVKEGTRFWAVGGRCPHAGGPLSK-GYLSRGRLRCPWHGACFSVQTGDIEEFP-----TLDCLPAFKVSVDE-GQVYVTAKLKDLERSRRLK---------------------------- T_rubripes_ENSTRUP00000030429 LTHCEGKFSAIGNQCTHYGAPLSK-GAVTGHTVRCPWHGACFNVHTGDLEEYP-----GIDSLPCHKVRIHN-SKVYVSVNKKTLRQEKRIK---------------------------- D_melanogaster_FBpp0080714 LVKQSGILRAVGAMCPHRGAPLAK-GVLSRNRVRCPWHGVCFNLETGDIENFP-----GLDSLPCHRVNVDSRGQVLVQVKRSYLLRHARIK---------------------------- A_aegypti_AAEL011158-PA LVKQKGKLSAIGNKCSHYGALLST-GALGEGRVRCPWHGACFNIETGDIEDFP-----GQDSLPCFKVTVEQ-GRVKIRAKRSELQSGKRTK---------------------------- D_melanogaster_FBpp0070319 LVKQNDRLLAVGAKCTHYGAPLQT-GALGLGRVRCPWHGACFNLENGDIEDFP-----GLDSLPCYRVEVGNEGQVMLRAKRSDLVNNKRLK---------------------------- C_elegans_F20D6.11 VINDEGRIYAINGLCSHYNFSLEN-GTYAKGRIRCPLHGACFNVRSGDIEDYP-----GFDSLHSYVVTVND-GNLIIKTTEKKLGSDRRIR---------------------------- 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ C_elegans_Y56A3A.32.1 -------------------------------------------------------------------PEQAEEKQETKDAEPKEQVDDRQTEEAVHARRAPAAAEEPAPSTSKADAV--- T_rubripes_ENSTRUP00000030183 PQVTCSHGNIFYSTNNS---LFFTTFYFLAVEATETKGNLNASSTEILF---------------AAPETEPQAEPAVGEPSP--ATPDSEAPVAPSETAEPAPALK------FEPQPLAT T_nigroviridis_ENSTNIP00000014785 PHAAEATETKGESTDNV---------IKQKRKCTEKRNHFIISFARTMLSVLPEPVNCYCFPPSADPETEPAAEPAAVEPSP--AAPGAEAPAASSETAEPVPESATVNM--RQWAALSQ C_intestinalis_ENSCINP00000012225 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000012070 PEDQPAAAPSIEEPSSP---AEVEAPKEETAPETTTPPGITSSKIHYMIC-----------PPLSEKWIASTADEPVVEGSPEEAAAAAAVPVVQEALTEPLVSSEPPPA--VESVVLAE H_sapiens_ENSP00000287295 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000039440 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005365 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000023188 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000002768 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008812 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000006568 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000026857 TQSEPPAAPSPAEPSPPAPDAEILAPIETA---------------------------------------DLPSDEPVIEASPEEAAEPPVV------EPEPSPPSEPTPAELTEPVADSE D_rerio_ENSDARP00000075330 VEESPVTEDIVESPEAVAEPIVKSSIPEPAVEIAVTEPVVEASVPESVIE-----------SPLMEPVVEASVQEPIIEATATETVAEAPEVIQSEEPIAPVVESEPVPVVSTEHVPEAS R_norvegicus_ENSRNOP00000008503 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000041104 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000008987 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000027660 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP008044-PA ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000006366 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL002016-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0077504 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000027578 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002538 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000038338 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000016816 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000007470 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000015763 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000085557 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000009976 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000012503 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000013415 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000010972 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000024275 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000382120 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000012379 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000053272 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000026974 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019217 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000018986 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000048427 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000010903 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000040932 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000111349 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010037 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000021125 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000011210 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000040612 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000027082 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000057179 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000039047 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003241 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000014484 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000030429 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0080714 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL011158-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0070319 ------------------------------------------------------------------------------------------------------------------------ C_elegans_F20D6.11 ------------------------------------------------------------------------------------------------------------------------ 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ C_elegans_Y56A3A.32.1 ----------EEKRSEQQSMKPSESTEENTTTTS-----ADGLLHCEYVIIGS-----GTAAYYAS-LSIRAKQAEAKVLMIGEEPELPYNRPPLSK--ELWWY-GDET--SATKLAYTP T_rubripes_ENSTRUP00000030183 AASPR-----ADLTDPSPALTRASASLKTTFPHT-----FRLPSHTPYLLIGG-----GTASFAAA-RSIRARDPGARVLIVTDEPDLPYMRPPLSK--ELWFS-DDPS--VTETLRFKQ T_nigroviridis_ENSTNIP00000014785 ASAARE----TFAFHPCGPVAPAAA--SDSPVVE-----HKLPSHTPYLLIGG-----GTASFAAA-RSIRARDPGARVLIVTDEPDLPYMRPPLSK--ELWFS-DDPS--VTETLRFKQ C_intestinalis_ENSCINP00000012225 -----------------DESVEQATEDVFGVPPA-----AEFPSQVQYLLIGG-----GTASYAAM-RAIKKRDVTAKILIISEDSYPPYMRPPLSK--ELWYS-DDEE--AAKKLQFKS O_latipes_ENSORLP00000012070 PAAAE-----PPASEPPEPQPEVLVESADSTPVS-----LKLPAHAPYLLIGG-----GTASFAAA-RSIRARDPGAKVLIVTDEPDLPYMRPPLSK--ELWFS-DDPA--VTDTLRFKQ H_sapiens_ENSP00000287295 ------------------------SASEGEEVPQ-----DKAPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGARVLIVSEDPELPYMRPPLSK--ELWFS-DDPN--VTKTLRFKQ X_tropicalis_ENSXETP00000039440 ----------AVKEVEATGMVDNQTPQTVESAHP-----AQLPSHVPFLLIGG-----GTASFAAA-RSIRARDPGARVLIVSDESELPYMRPPLSK--ELWFS-EDPH--VTETLRFKQ T_guttata_ENSTGUP00000005365 ------------------------QDTAGKFCPH-----PKVPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGARVLIVSEDPALPYMRPPLSK--ELWFS-DDPN--VTETLRFKQ P_pygmaeus_ENSPPYP00000023188 ------------------------SASEGEEVPQ-----DKAPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGARVLIVSEDPELPYMRPPLSK--ELWFS-DDPN--VTKTLRFKQ E_caballus_ENSECAP00000002768 ------------------------SAPEGEPVPH-----VRVPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGARVLIVSEDPELPYMRPPLSK--ELWFS-DDPN--VTKTLRFRQ A_carolinensis_ENSACAP00000008812 --------------------------PAAEAAPL-----PEFPSHVPFLLIGG-----GTAAFAAA-RSIRARDPAARVLIVSEDPEFPYMRPPLSK--ELWFS-EDPD--VTETLRFKQ M_mulatta_ENSMMUP00000006568 ------------------------SASEGEEVPQ-----DRVPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGARVLIVSEDPELPYMRPPLSK--ELWFS-DDPN--VTKTLRFKQ G_aculeatus_ENSGACP00000026857 SPAAES----AAAAKPAEPQLEAVTESGDASPAS-----HKVSSHTPYLLIGG-----GTASFAAA-RSIRARDPGARVLIVTDELVPPYMRPPLSK--ELWFS-DDPS--VTETLRFKQ D_rerio_ENSDARP00000075330 SVSESVFLFWPAAAPETSPAAAPAAEPIDPTAPH-----LDVLEHAPYLLIGG-----GTASFAAA-RSIRARDPGARVLIITEESDLPYMRPPLSK--ELWFS-DDPK--VTESLRFKQ R_norvegicus_ENSRNOP00000008503 ------------------------SAAEGGSVPP-----IRVPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGARVLIVSEDPELPYMRPPLSK--ELWFS-DDPN--VTKTLQFRQ M_musculus_ENSMUSP00000041104 ------------------------SATEGGSVPQ-----IRAPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGARVLIVSEDPELPYMRPPLSK--ELWFS-DDPN--VTKTLQFRQ B_taurus_ENSBTAP00000008987 ------------------------SALEGEPEPQ-----VRIPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGARVLIVSEDPELPYMRPPLSK--ELWFS-DDPN--VTKTLRFKQ C_familiaris_ENSCAFP00000027660 ------------------------PAPEGEPVPQ-----VRVPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGARVLIVSEDPELPYMRPPLSK--ELWFS-DDPN--VTKTLRFRQ A_gambiae_AGAP008044-PA -----------------------------YPASS-----KDLPKHVPYLLVGG-----GTASIAAF-RAIRVHDPKAKVMMITNELEMPYMRPPLSK--ELWFN---PT--EAEPLKFRQ G_gallus_ENSGALP00000006366 ------------------------------PEAR-----PEVPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGARVLIVSEDPALPYMRPPLSK--ELWFS-DDPH--VTETLRFKQ A_aegypti_AAEL002016-PA -----------------------------FPASS-----KDLPSEVPYLLIGG-----GTASFAAF-RAIKGHDAKAKVLVITNETELPYMRPPLSK--ELWFNPEDKA--QLEPLKFRQ D_melanogaster_FBpp0077504 -------------------------GLATSPPSS-----EDLPKHVPYLIIGG-----GTAAFSAF-RAIKSNDATAKVLMISNEFRKPYMRPPLSK--ELWYT-PNPNEDPIKDYRFKQ M_domestica_ENSMODP00000027578 ------------------------SVPE--TRAQ-----IKAPTHAPFLLIGG-----GTAAFAAA-RSIRARDPGARVLIISEDPELPYMRPPLSK--ELWFS-DDPN--VTNTLRFKQ O_cuniculus_ENSOCUP00000002538 ------------------------SAPEGEPVSQ-----VRVPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGARVLIVSEDPELPYMRPPLSK--ELWFS-DDPN--VTKTLRFKQ P_troglodytes_ENSPTRP00000038338 ------------------------SASEGEEVPQ-----DKAPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGARVLIVSEDPELPYMRPPLSK--ELWFS-DDPN--VTKTLRFKQ T_guttata_ENSTGUP00000016816 --------------------------------PH-----PKVPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGARVLIVSEDPALPYMRPPLSK--ELWFS-DDPN--VTETLRFKQ G_gorilla_ENSGGOP00000007470 ------------------------XXSEGEEVPQ-----DKAPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGARVLIVSEDPELPYMRPPLSK--ELWFS-DDPN--VTKTLRFKQ C_intestinalis_ENSCINP00000015763 ------------------------------PMVQ-----TQNEDGPHVVIVGG-----GPASVTCA-ETLRQKSFLGKITILSADPYLPYDRTKLSK--AM------------------- D_rerio_ENSDARP00000085557 ------------------------------VMSKCSAVINSSTGFSHVLIIGS-----GPAGLVCA-ETLRQEGFTDRIVICTTDKHLPYDRPKLSK--SL------------------- O_latipes_ENSORLP00000009976 ------------------------------PMARCSSVIHSNTGFSHVLIIGS-----GPAALVCA-ETLRQEGFTDRIVMCTMDRHPPYDRPKLSK--SL------------------- G_gallus_ENSGALP00000012503 ------------------------------MMAKCISLSNYNLSSTNVLIIGA-----GAAGLVCA-ETLRQEGFSDRIVMCTMDRHLPYDRPKLSK--SM------------------- P_pygmaeus_ENSPPYP00000013415 ------------------------------VMAKCISPSAGYSSSTNVLIVGA-----GAAGLVCA-ETLRQEGFSDRIVLCTLDRHLPYDRPKLSK--SL------------------- T_guttata_ENSTGUP00000010972 ------------------------------MMAKCISLSNYNLSSTNVLIIGA-----GAAGLVCA-ETLRQEGFSDRIVMCTMDRHLPYDRPKLSK--SM------------------- P_troglodytes_ENSPTRP00000024275 ------------------------------VMAKCISPSAGYSSSTNVLIVGA-----GAAGLVCA-ETLRQEGFSDRIVLCTLDRHLPYDRPKLSK--SL------------------- H_sapiens_ENSP00000382120 ------------------------------VMAKCISPSAGYSSSTNVLIVGA-----GAAGLVCA-ETLRQEGFSDRIVLCTLDRHLPYDRPKLSK--SL------------------- G_aculeatus_ENSGACP00000012379 ------------------------------PMARCSAVINSSSGFSHVLIIGS-----GPAGLVCA-ETLRQEGFTDRIVMCTKDRHPPYDRPKLSK--SL------------------- B_taurus_ENSBTAP00000053272 ------------------------------VMATCISPSAGYSGSTNVLIVGA-----GAAGLVCA-ETLRQEGFSDRIVLCTLDRHLPYDRPKLSK--SL------------------- M_mulatta_ENSMMUP00000026974 ------------------------------VMAKCISPSAGYSSSTNVLIVGA-----GAAGLVCA-ETLRQEGFSDRIVLCTLDRHLPYDRPKLSK--SL------------------- T_nigroviridis_ENSTNIP00000019217 ------------------------------NMGA-----AVLGFTHTVVLLGGGCVNAGAASLICA-EVLRQENFPGRIIMATRDELLPYDKTRLSK--VM------------------- T_nigroviridis_ENSTNIP00000018986 ------------------------------AMARCSAVINASTGFSHILIIGS-----GPAGLLCA-ETLRQEGFTDRIVMCTMDRHPPYDRPKLSK--SL------------------- R_norvegicus_ENSRNOP00000048427 ------------------------------VMAKCISPSAGH-SSTNVLIVGA-----GAAGLVCA-ETLRQEGFSDRIVLCTLDRHLPYDRAKLSK--SL------------------- A_carolinensis_ENSACAP00000010903 ------------------------------VMGKCISLSNYSISSTNVLIIGA-----GPAGLVCA-ETLRQEGFSDRIVMCTMDRHLPYDRPKLSK--SM------------------- T_rubripes_ENSTRUP00000040932 ------------------------------AMARCSAVINSSTGFSHVLIIGS-----GPAGLVCA-ETLRQEGFTDRIVMCTMDRHPPYDRPKLSK--SL------------------- M_musculus_ENSMUSP00000111349 ------------------------------VMAKCISPSAGHSSSTNVLIVGA-----GAAGLVCA-ETLRQEGFSDRIVLCTLDRHLPYDRAKLSK--SL------------------- O_latipes_ENSORLP00000010037 ------------------------------EMCT-----LEPGAKHTVLLVGG-----GPASLVCA-ETLRQNCYQGRIIMVTKDSLPPYDKTKLSK--VM------------------- T_nigroviridis_ENSTNIP00000021125 ------------------------------EMCS-----RKPDIKHTILLIGG-----GPAALVCA-ETLRQNCYEGRIVMVTKDTLPPFDKPKLSK--AL------------------- G_aculeatus_ENSGACP00000011210 ------------------------------EMCT-----REPDIQHTTLLIGG-----GPASLVCA-ETLRQNCYQGRIVIVTKDTLPPFDKPKLSK--AL------------------- T_rubripes_ENSTRUP00000040612 ------------------------------EMCS-----RIADIKHTILLIGG-----GPAALVCA-ETLRQTCYEGRIIMVTRDALPPFDKPKLSK--AL------------------- G_aculeatus_ENSGACP00000027082 ------------------------------RMGA-----AVAGVTHTVLLLGG-----GAASLICA-ETLRQENFGGRIIMVTRDDLLPYDKTRLSK--VM------------------- X_tropicalis_ENSXETP00000057179 ------------------------------HLCYKMTLRMNKKKITLIVILNAYIL--QTFGVISSTEIKKQKIFFAYISKKELEAILPGDRLAILAFISM------------------- G_gallus_ENSGALP00000039047 ------------------------------DMSK-----RCLLNRNTMLLLGG-----GVAALTCA-ETLRQEGFTGRIIMATKEKHAPYDKSKLSK--EM------------------- O_latipes_ENSORLP00000003241 ------------------------------SMGG-----AVPGVAHTILLLGG-----GIASLMCA-ETLRQEKFGGRIIMVSRDHLLPYDKTRLSK--VM------------------- A_carolinensis_ENSACAP00000014484 ------------------------------LMSK-----RDPLDPRTVLLLGA-----GPASLTCA-ETLRQEGFSGRIIMVTQEGHLPYDRTKLSK--DI------------------- T_rubripes_ENSTRUP00000030429 ------------------------------TMGA-----AVPGFTHTVVLLGG-----GAASLICA-EVLRQQNFPGRIIMATRDDLLPYDKTRLSK--VM------------------- D_melanogaster_FBpp0080714 ------------------------------SMAC-----RNWQDQRHFVVVGG-----GPSGAVCV-ETLRQEGFTGRLTLVCGEKHLPYDRTRIMN--LL------------------- A_aegypti_AAEL011158-PA ------------------------------AMVK-----KEKEDERTFVVIGG-----GPSGAICA-EALRQEGFTGRVIMINKEPCLPYDRILVSK--TM------------------- D_melanogaster_FBpp0070319 ------------------------------NMVR-----RKPDDQRVFIVVGG-----GPSGAVAV-ETIRQEGFTGRLIFVCREDYLPYDRVKISK--AM------------------- C_elegans_F20D6.11 ------------------------------HLPK-----MKQCNDRPVVIIGG-----GVATATFI-EHSRLNGLITPILVISEESLPPYDRVLLSK--KP------------------- 610 620 630 640 650 660 670 680 690 700 710 720 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ C_elegans_Y56A3A.32.1 LSGKKRDIFYEVDG-FFVSPEDLPKAVHGGVALLRGRKAVKICEEDKKVILEDGTTIGYDKLLIAT-GVR-----PKKEQVFEEASEEAKQKITYFHYPADFKRVERGLADKSVQKVTII T_rubripes_ENSTRUP00000030183 WNGKERSIYFQPAS-FYISAEELDSAENGGVAVLTGKKVVHMDVRGNKVKLDDDTEISYDKCLIAT-GGV-----PRNLQVIDRAAEDVKSRTTLFRKIEDFKSLDK--VSRNIESITII T_nigroviridis_ENSTNIP00000014785 WNGKERSIYFQPAS-FYISAEELDSAENGGVAVLPGKKVVHMDVRGNKVKLDDNTEISYDKCLIAT-GGV-----PRNLQVIERAAEDVKSRATLFRKIEDFKSLDK--VSRNIESITII C_intestinalis_ENSCINP00000012225 WNGKWRDVYFEKPD-YYCAPSDLPAKSEGGVAVANNTRVVSLNPTDNIATLKDGTEIKYDKCLIAT-GGQ-----PKNLPVFRKASAEIQKKVSTYRTASDFTELNN--ITDGVKSITVI O_latipes_ENSORLP00000012070 WNGKERSIYFQPPS-FYIRPEDLDGAENGGVAVLNNRKVVYMDVRGNKVKLDDDTEISYDKCLIATAGGI-----PRNLQLIERAGEEVMKKTTLFRKIEDFKSLDK--VSRNVKSVTII H_sapiens_ENSP00000287295 WNGKERSIYFQPPS-FYVSAQDLPHIENGGVAVLTGKKVVQLDVRDNMVKLNDGSQITYEKCLIAT-GGT-----PRSLSAIDRAGAEVKSRTTLFRKIGDFRSLEK--ISREVKSITII X_tropicalis_ENSXETP00000039440 WNGKERSIFFQPPS-FYVPPEQLMSVENGGVSVLTGKKVVHMDVRENKVKLDDGTQISYEKCLIAT-GGV-----PRSLPAIERAGEEVTKRTTLFRRISDFRTLEA--ISSSVGSITII T_guttata_ENSTGUP00000005365 WNGKERSIYFQPPS-FYVPVEDLPSVENGGVAVLPGKKVVHMDVRGNTVKLNDGTQISYDKCLIAT-GGS-----PRNLPAIERAGKDVQKRLTLFRKIEDFRRLEK--ISREVKSITII P_pygmaeus_ENSPPYP00000023188 WNGKERSIYFQPPS-FYVSAQDLPHIENGGVAVLTGKKVVQLDVRDNMVKLNDGSQITYEKCLIAT-GGT-----PRSLSAIDRAGAEVKSRTTLFRKIGDFRSLEK--ISREVKSITII E_caballus_ENSECAP00000002768 WNGKERSIYFQPPS-FYVSAEDLPHIENGGVAVLTGKKVIQLDVRGNMVKLNDGSQITYEKCLIAT-GGT-----PRSLSAIDRAGAEVKSRTTLFRKIGDFRTLEK--ISREVKSITII A_carolinensis_ENSACAP00000008812 WNGKERSIYFQPPS-FYVSPRDLPHIENGGVAVLSGRKVVHMDVRGNVVTLDNGTQISYDKCLLAT-GGS-----PRSLPVIERAGKEVQEKLTLFRKIEDFRSLEK--ISREVQSITII M_mulatta_ENSMMUP00000006568 WNGKERSIYFQPPS-FYVSAQDLPHIENGGVAVLTGKKVVQLDVRGNMVKLNDGSQITYEKCLIAT-GGT-----PRSLSAIDRAGAEVKSRTTLFRKIGDFRSLEK--ISREVKSITII G_aculeatus_ENSGACP00000026857 WNGKERSIYFQPPS-FYINAEELGSAENGGVAVLTGKKVVHMDVRGNKIKLDDDTEISYDKCLIAT-GGV-----PRNLQVIERAGEEVMKRTTLFRKVEDFKSLDK--VSRNVKSITII D_rerio_ENSDARP00000075330 WNGKERSIYFQPPS-FYVSPADLAKVENGGVAVLTDSKVVHMDVRGNKVKLSDGSEISYEKCLIAT-GGV-----PRNLQVIDRAGEEVIKRTTLFRKIEDFRSLEK--ISREVKSITII R_norvegicus_ENSRNOP00000008503 WNGKERSIYFQPPS-FYVSAQDLPHIENGGVAVLTGKKVVHLDVRGNMVKLNDGSQITFEKCLIAT-GGT-----PRSLSAIDRAGAEVKSRTTLFRKIGDFRALEK--ISREVKSITVI M_musculus_ENSMUSP00000041104 WNGKERSIYFQPPS-FYVSAQDLPNIENGGVAVLTGKKVVHLDVRGNMVKLNDGSQITFEKCLIAT-GGT-----PRSLSAIDRAGAEVKSRTTLFRKIGDFRALEK--ISREVKSITVI B_taurus_ENSBTAP00000008987 WNGKERSIYFQPPS-FYVSAQDLPRVENGGVAVLTGKKVVQLDVRGNVAKLNDGSQITYEKCLIAT-GGT-----PRSLSAIDRAGAEVKSRTTLFRKIEDFRTLEK--ISREVKSITII C_familiaris_ENSCAFP00000027660 WNGKERSIYFQPPS-FYVAAQDLPHIENGGVAVLTGKKVVHLDVRGNMVKLNDGSQITYEKCLIAT-GGT-----PRSLSAIDRAGAEVKSRTTLFRKIGDFRTLEK--ISREVKSITII A_gambiae_AGAP008044-PA WNGSERSIFYEPND-YYIDPSKLSDAPNGGVAVARGYEVHRLDVVNRKAILTDGTEISYDKCLIAT-GAR-----PKNLPIFESAPRAVRERVTLFKSVYDFEQLSS--QLQDGNRVAIV G_gallus_ENSGALP00000006366 WNGKERSIYFQPPS-FYVHARDLPFVENGGVAVLSGKKVVHMDVRGNTVKLNDGTQISYDKCLIAT-GTI-----EEEEEGETRLPFEVKERVTLTSKIEDFKNLEK--ISRQVKSITII A_aegypti_AAEL002016-PA WNGVERSIYFEPDD-FYIDPTKLMESPNGGVAIARGYEVQRIDVVNRKAILTDGTEIKYGECLLAT-GAR-----PKNLPVFESAPLAVKERVSMFKAVSDFEELTE--KLNEGSKIAII D_melanogaster_FBpp0077504 WTGSERSLFFEPDE-FFIDPEDLDDNANGGIAVAQGFSVKKVDAQKRIVTLNDGYEISYDECLIAT-GCA-----PKNLPMLRDAPPSVLEKVMVYRTPDDFDRLRK--LAAEKRSITIV M_domestica_ENSMODP00000027578 WNGKERRYASRSTR-WWTRARSWVPMISWEV-LISEEFVVQLDVRDNMVKLNDGSQITFEKCLIAT-GGT-----PRNLSAIDRAGPEVKSRTTLFRKIGDYRSLEK--ISREVSSITVI O_cuniculus_ENSOCUP00000002538 WNGKERXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXVVQLDVRGNMVKLNDGSQITYEKCLIAT-GGT-----PRNLSAIDRAGAEVKSRTTLFRKIGDFRALEK--ISREVKSITII P_troglodytes_ENSPTRP00000038338 WNGKERSIYFQPPS-FYVSAQDLPHIENGGVAVLTGKKVVQLDVRDNMVKLHDGSQITYEKCLIAT-GGT-----PRSLSAIDRAGAEVKSRTTLFRKIGDFRSLEK--ISREVKSITII T_guttata_ENSTGUP00000016816 WNGKERSIYFQPPS-FYVPVEDLP-CENGGVAVLPGKKVVHMDVRGNTVKLNDGTQISYDKCLIAT-GGS-----PRNLPAIERAGKDVQKRLTLFRKIEDFRRLEK--ISREVKSITII G_gorilla_ENSGGOP00000007470 WNGKERXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXVVQLDVRDNMVKLNDGSQITYEKCLIAT-GGT-----PRSLSAIDRAGAEVKSRTTLFRKXXXXXXXXX--XXXXXXXXXXX C_intestinalis_ENSCINP00000015763 -DIKPEAIFLRPQE-FY---------DAVNIKIINNKRVNGVNAETQVVTCEDGDTFKYDKLMVAT-GGR-----PRTLPI----PGWDLKNVYVLRTPNDANAIAE---VAKGRKVVIC D_rerio_ENSDARP00000085557 -ESTAEQLQLRSSD-FF---------QMHDIEVLLEKEVVSVDVKTHTVTFRDGFKMEYRKLFIAT-GSR-----PKPLSY----KGKDVGNVFHLRTPEDANSIVT---LASSKNAVII O_latipes_ENSORLP00000009976 -ESTAEQLRLRSVD-FL---------QDHDIELLTEKEVAAVDVKTRTVTFEDGLKMEYRKLFIAT-GSK-----PKPMNY----KGNEVKNVFHLQTPEDANSIAR---LANNKNAVIV G_gallus_ENSGALP00000012503 -DSHPEQIALRPKE-FF---------RTYDIEVLTEMQAAAVDIKNKTAVFKDGFKMEYNKLLIAT-GNT-----PKALSC----KGKEVENVFNIRTPEDANRVVK---LATSKNVVIV P_pygmaeus_ENSPPYP00000013415 -DTQPEQLALRPKE-FF---------RAYGIEVLTEAQVVTVDVRNKKVVFKDGFKLEYSKLLLAP-GSS-----PKTLSC----KGKEVENVFTIRTPEDANRVVR---LARGRNVVIV T_guttata_ENSTGUP00000010972 -DSHPEQIALRPKE-FF---------CTYDIEVLTEMQVAAVDVKSKIAVFKDGFKMEYNKLLIAT-GST-----PKTLSC----KGKEMENVFNIRTPEDANRVVK---LATSKNVVIV P_troglodytes_ENSPTRP00000024275 -DTQPEQLALRPKE-FF---------RAYGIEVLTEAQVVTLDVRNKKVVFKDGFKLEYSKLLLAP-GSS-----PKTLSC----KGKEVENVFTIRTPEDANRVVR---LARGRNVVVV H_sapiens_ENSP00000382120 -DTQPEQLALRPKE-FF---------RAYGIEVLTEAQVVTVDVRTKKVVFKDGFKLEYSKLLLAP-GSS-----PKTLSC----KGKEVENVFTIRTPEDANRVVR---LARGRNVVVV G_aculeatus_ENSGACP00000012379 -ESTAEQLRLRSMD-FL---------QDHDIELLVDKEAVSIDVKTRSVTFEDGSRMEYKKLFIAT-GSK-----PKPMVY----NGKDVRNVFHLRTPEDANSIAR---LANNKNAVIV B_taurus_ENSBTAP00000053272 -DAQPEQLALRPKE-FF---------RAHGIEVLTEAQVVTVDVRNKKAVFKDGFKLEYSKLLLAP-GSS-----PKTLSC----KGKDVENVFTIRTPEDANRVVR---LARGRNAVVV M_mulatta_ENSMMUP00000026974 -DTQPEQLALRPKE-FF---------RAYGIEVLTEAQVVTVDVRNKKVVFKDGFKLEYSKLLLAP-GSS-----PRTLSC----KGKEMENVFTIRTPEDANRVVR---LARGRNVVIV T_nigroviridis_ENSTNIP00000019217 -NVESESILLRRRE-FF---------LQYDIEVWLRKEALSVNTDEKTVTFDDGSVQSYDQLLIAT-GSR-----AKSLNV----PGMNLENVKMLETPEDARQIHD---ACMGSRVVLV T_nigroviridis_ENSTNIP00000018986 -ESTAEQLRLRSAD-FL---------RDHDIELITEKEAVLVDVKSRSVTFEDGLKMDYRKLFIAP-GSR-----PRAMSY----KGKDVRNVFHLRTPEDANNIAK---LSSNKNAVIV R_norvegicus_ENSRNOP00000048427 -DAQPEQLALRPKE-FF---------RAYGIEMLTEAQVVTVDVRNKKVVFKDGFKLEYSKLLLAP-GSS-----PKTLTC----KGKDIENVFTIRTPEDANRVLR---LARGRNAVVV A_carolinensis_ENSACAP00000010903 -DSHADQIALRPKE-FF---------RTYDIEVLTEMQVVAVDVKNKTAVFKDGFKMEYNKLLLAT-GNT-----PKTLSC----KGKEVENVFTIRTVEDANRVVK---LATSKNAVVV T_rubripes_ENSTRUP00000040932 -ESTAEQLRLRSAD-FL---------RDHDIELITEKEAVLVDVKSRSVTFGDGLKMDYRKLFIAT-GSRCHAKSPKPMSY----KGKDVRNVFHLCTPEDANSIAQ---LSNNKNAVIV M_musculus_ENSMUSP00000111349 -DAQPEQLALRPKE-FF---------RAYGIEMLTEAQVVTVDVRNKKVVFKDGFKLEYSKLLLAP-GSS-----PKTLTC----KGKDVENVFTIRTPEDANRVLR---LARGRNAVVV O_latipes_ENSORLP00000010037 -NVESSSLLLRPAE-FY---------QQYGIEVWTNKEVVSVNPGNKLVQINDGALQHYDQLLIST-GCR-----ARPLSC----PGSDLKGVHLLQSYDDAKEIHS---SGTKQKAVVI T_nigroviridis_ENSTNIP00000021125 -NLDSGSVLLRSAD-FY---------QQYGIEVWTQKEVVSVDTVDKAVELNDGSSHNYDQLLIST-GCR-----ARPLGC----PGWDLQGVKLLQTHDDAKEIHA---SCQERNVVVI G_aculeatus_ENSGACP00000011210 -DLDSSSILLRPSD-FY---------QQHGVEVWTRKEVVSVDPAEKSVKLSDGSLQRYDQLLIST-GCR-----ARPLDC----PGWDLHGVKLLQTHEDANEIHH---SALGQKAVVI T_rubripes_ENSTRUP00000040612 -HLDRSSILLRSAD-FY---------QQYGIEVWTEKEVISVNTVNKAVKMIDGTWLNYDQLLIAT-GCR-----ARPLSC----PGWDLKGVKLLQTHDDANEIHS---SCQGQNAVII G_aculeatus_ENSGACP00000027082 -NVENDSILLRRSE-FF---------YQHDIEVWLRKEAVSVDTDMKTVAFEDGSVQSYDHLLICS-GVL-----AKGLDV----PGTKLDNVRMLETPEDARHIHT---ACLGSDVVLV X_tropicalis_ENSXETP00000057179 -DSQAEQIFLRSKE-FF---------HTYDIEVLTESQVVGVDTKNKMVLFKDGFRMEYNKLLIAT-GNT-----PKTLKC----KGKELDNVFTIRTPEDANKVVR---LASSKNAVIV G_gallus_ENSGALP00000039047 -NLKAEDIYLRKPE-FL---------CAHGIELWTEKEAASVDFQKQKVHFMDGSSQKYNQLLIAT-GGH-----SSFLKV----PGADLQNVCHLQTPEDASKVLE---LASGKNLVIV O_latipes_ENSORLP00000003241 -NVESDTIVLRRME-FY---------HQYDIEVWLRKEVLSVDTDRKTVAFDDGLVQNYDQLLIST-GCR-----AKALDV----PGTKLRNIMMLETPEDARQIHA---ACMGSNVVLV A_carolinensis_ENSACAP00000014484 -GAQAEDILLRPPS-FM---------ETYGIEVWRQKEVVSINPDDKVAQFSDGTSQGYDNLLIAT-GSR-----PRLLGC----SGCDLE-VCTLLTPEDG-RILR---LATGRKVAII T_rubripes_ENSTRUP00000030429 -NVETESILLRRME-FY---------LQYDIEVWLRKEAQSVNTDEKTVTFDDGSVQSYDQLLIAT-GCR-----AKGLNV----PGINLDNVKMLETPEDARQIHE---ACMGSKVVLV D_melanogaster_FBpp0080714 -NTYTKNLALREEQ-FY---------KDYGIEMQLGVSAERLDTNCNTLHCTNGKTFPYDKIYIAT-GYS-----AVTPNI----PGVHLKNVKVIRNIGDARSIFK--MVDKSTQVVCL A_aegypti_AAEL011158-PA -DFDLEKKLLRDEK-FY---------AEHEIETMIGTEVTSLNSANRELTLSNGYKIKYDKVYIAT-GSE-----ARKAPI----EGADMPNVCVLRSNEHSKHVNG--QLSPDKHVVVL D_melanogaster_FBpp0070319 -NLEIEQLRFRDEE-FY---------KEYDIELWQGVAAEKLDTAQKELHCSNGYVVKYDKIYLAT-GCS-----AFRPPI----PGVNLENVRTVRELADTKAILA--SITPESRVVCL C_elegans_F20D6.11 -AATGEDIRLRKDDAFY---------EERNVKFLLKTSVIAVNHKSREVSLSNGETVVYSKLIIAT-GGN-----VRKLQV----PGSDLKNICYLRKVEEANIISN---LHPGKHVVCV 730 740 750 760 770 780 790 800 810 820 830 840 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ C_elegans_Y56A3A.32.1 GNGL----LASELSYSIKRKYG---ENVEVHQVFEEKYPAEDILPEHIAQKSIEAIRKGGVDVRAEQKVEGVRKCC-KNV-VLKLSDGSELRTDLVVVATGEEPNSEIIEASGLKIDEKL T_rubripes_ENSTRUP00000030183 GGGF----LGSELACALGRRSN--ESGLEVVQMYPEKGNMGKVLPEYLSNWTTEKVKREGVKVITEALVKSVTFKD-DKL-EIQLKDGRKVRTDHIVAAVGLEPNIDLAKSAGLEVDPDF T_nigroviridis_ENSTNIP00000014785 GGGF----LGSELACALGRRSN--ESGLEVVQMYPEKGNMGKVLPEYLSNWTTDKVKREGVKVITEALVKSVTFKD-EKL-EIQLKDGRKVRTDHIVAAVGLEPNVDLAKSAGLEVDPDF C_intestinalis_ENSCINP00000012225 GGGF----MGSELACALGHKGQ--KVGFEVNQIFPENGNMGNVLPEYLTKWTTSKVKSEGVNVITDTVVNNVTMQD-GRL-KLQLRTGQEILTDHVVVAVGLGIDTSLAESGGLETDERF O_latipes_ENSORLP00000012070 GGGF----LGSELACALGRRST--ESGLEVIQMFPEKGNMGKVLPEYLSNWTTEKVKKEGVKVLTEALVKSVSCKD-DQL-EIKLKDGRVVTTDHIVAAVGLEPNVDLAKSAGLEVDSDF H_sapiens_ENSP00000287295 GGGF----LGSELACALGRKAR--ALGTEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSS-GKL-LIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDF X_tropicalis_ENSXETP00000039440 GGGF----LGSELACALGRKGT--QTSLEVIQMFPESGNMGKVLPEYLSHWTTEKVQREGVNVLSDAVVKSVSYQN-GKL-HIQLKDGRQVQTDHIVAAVGLEPNTELAKSAGLELDGDF T_guttata_ENSTGUP00000005365 GGGF----LGSELACALGRRAR--TRGLEVIQLFPENGNMGKVLPEYLSNWTTEKVRREGVNVLPNAVVKSVSVSG-NRL-VIKLKDGRKVETDHIVAAVGLEPNVELAKSAGLEVDSDF P_pygmaeus_ENSPPYP00000023188 GGGF----LGSELACALGRKAR--ALGTEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSS-GKL-LIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDF E_caballus_ENSECAP00000002768 GGGF----LGSELACALGRKAR--ALGTEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVLPDAIVQSVGVSG-GKL-LIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDF A_carolinensis_ENSACAP00000008812 GGGF----LGSELACALGRKAQ--SRGLEVIQMFPENGNMGKVLPEYLSNWTTNKVRQEGVNVMPNSVVKSVSVAG-NRL-LIKLKDGRKVETDHIVAAVGLEPNVELAKSAGLEVDSDF M_mulatta_ENSMMUP00000006568 GGGF----LGSELACALGRKAR--ALGTEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSS-GKL-LIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDF G_aculeatus_ENSGACP00000026857 GGGF----LGSELACALGRRST--ESDLEVIQMYPEKGNMGKVLPEYLSNWTTEKVKKEGVKIISEALVKSVVSKD-DKL-EIQLKDGRLVKTDHIVAAVGLEPNVDLAKSAGLEVDSDF D_rerio_ENSDARP00000075330 GGGF----LGSELACALGRRSA--DPGLEVMQLFPEKGNMGKVLPEYLSNWTTEKVRKEGVNVITDAVVKNVTYKN-DKL-EIKLKDGRLVKTDHIVAAVGLEPSVELAKSAGLEVDSDF R_norvegicus_ENSRNOP00000008503 GGGF----LGSELACALGRKSQ--ASGIEVIQLFPEKGNMGKILPEYLSNWTMEKVKREGVKVMPNAIVQSVGVSG-GKL-LIKLKDGRKVETDHIVTAVGLEPNVELAKTGGLEIDSDF M_musculus_ENSMUSP00000041104 GGGF----LGSELACALGRKSQ--ASGIEVIQLFPEKGNMGKILPQYLSNWTMEKVKREGVKVMPNAIVQSVGVSG-GRL-LIKLKDGRKVETDHIVTAVGLEPNVELAKTGGLEIDSDF B_taurus_ENSBTAP00000008987 GGGF----LGSELACALGRKAR--ASGTEVIQLFPEKGNMGKVLPEYLSNWTMEKVRREGVKVLPSAIVQSVGVSA-GRL-LIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDF C_familiaris_ENSCAFP00000027660 GGGF----LGSELACALGRKAR--ALGTEVIQLFPEKGNMGKILPEYLSNWTTEKVRREGVKVLPNAIVQSVGVSG-GRL-LIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDF A_gambiae_AGAP008044-PA GGGF----LGSELACALSKSEQTRKKKVEVFQLFHEGGNMAKVLPEYLSSWTTERLREEGVKVWPKTQVKAVEMQG-SKL-KLTLMDDSVLLVDRVIVAVGSEPNTDLAKTSGLEVDGKN G_gallus_ENSGALP00000006366 GGGF----LGSELACALGRRAQ--TRNLEVIQLFPENGNMGKVLPEYLSNWTTEKVRREGVNVMPNAVVKSVSVSG-NRL-VIKLKDGRKVETDHIVAAVGLEPNVELAKSAGLEVDSDF A_aegypti_AAEL002016-PA GGGF----LGSELSCALARCSEIRNKNFEVYQLFHEEGNMGKILPEYLSQWTTERVREEGVKVWPKIQVKAAEVQD-KKL-KLTLTDDSCLVVDHAIVAVGSEPNTDLAKTSNLETDPSM D_melanogaster_FBpp0077504 GNGF----IGSELACSLAHYSR-ENNGGKVYQVFQENANMSKVLPNYLSRWTTAKMEAQGVCVIPNASIRSAVRDE-TNL-KLELNNGMTLMSDVVVVCVGCTPNTDLAGPSRLEVDRSL M_domestica_ENSMODP00000027578 GGGF----LGSELACALARKAR--TLGTEVIQLFPEKGNMGKILPEYLSNWTTEKVRKEGVKVMPNAVVQAVGVKS-GKL-LIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEVDSDF O_cuniculus_ENSOCUP00000002538 GGGF----LGSELACALGRKAR--ASGKEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSG-GKL-LIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDF P_troglodytes_ENSPTRP00000038338 GGGF----LGSELACALGRK--------------PEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSS-GKL-LIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDF T_guttata_ENSTGUP00000016816 GGGF----LGSELACALGRRAR--TRGLEVIQLFPENGNMGKVLPEYLSNWTTEKVRREGVNVLPNAVVKSVSVSG-NRL-VIKLKDGRKVETDHIVAAVGLEPNVELAKSAGLEVDSDF G_gorilla_ENSGGOP00000007470 XXXX----XXXXXXXXXXXXXR--ALGTEVIQLFPEKGNMGKILPEYLSNWTMEKVRRXXXXXXXXXXXXXXXXXX-XXX-XXXXXXXXXVETDHIVAAVGLEPNVELAKTGGLEIDSDF C_intestinalis_ENSCINP00000015763 GASF----IGMEVAASLVSKAE------SISVCEFFSVPFERVLGKEVGLFLQKMHESKGVKFHMNASMVELKGEN-GAVAKAILKDGSELEADLVIAGVGMIPATEFLKDTGIQISSH- D_rerio_ENSDARP00000085557 GTSF----IGMEVAAALTDKAH------SVSVIGIEAVPFRKALGEKVGKALMKLFEANRVKFYMLNEVWEMRGHN-GQLKEVVLKSGKVLRADVCVIGIGSSPATAFLKQSGVHIDSK- O_latipes_ENSORLP00000009976 GTSF----VGMEVAAALTDKAH------SVSVIGIESLPFKKALGEKVGKVIMKLFEANRVKFYMLNEVSEMIGHH-GQLKEVVLKSGKVLRADVCVIGAGSVPASGFLKQSGIHLDSK- G_gallus_ENSGALP00000012503 GASF----LGMEVAAYLTERAH------SVSVVELEEVPFKKFFGERVGRAVMKMFESHRVKFYMQTEVSELREQE-SKLKEVVLKSGKVLRADVCVVGIGAVPATGFLKQSGINIDSK- P_pygmaeus_ENSPPYP00000013415 GAGF----LGMEVAAYLTEKAH------SVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELRGQE-GKLKEVVLKSSKVVRADVCVVGIGAVPATGFLRQSGIGLDSR- T_guttata_ENSTGUP00000010972 GASF----LGMEVAAYLAERAH------SVSLVELEHVPFKKFFGERVGRAVMKMFENNRVKFYMQTEVSELREQE-GKLKEVVLKSGKVLRADVCVVGIGAVPATGFLKQSGINIDSK- P_troglodytes_ENSPTRP00000024275 GAGF----LGMEVAAYLTEKAH------SVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELRGQE-GKLKEVVLKSSKVVRADVCVVGIGAVPATGFLRQSGIGLDSR- H_sapiens_ENSP00000382120 GAGF----LGMEVAAYLTEKAH------SVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELRGQE-GKLKEVVLKSSKVVRADVCVVGIGAVPATGFLRQSGIGLDSR- G_aculeatus_ENSGACP00000012379 GTSY----VGMEVAAALTDKAH------SVSIIGIESVPFKKALGEKVGKAVMKLFEVNRVKFYMLNEVSEMIGQH-GQLKEVVLKSGKVLRADVCVIGAGSIPATGFLKQSGIHMDSR- B_taurus_ENSBTAP00000053272 GAGF----LGMEVAAYLTEKAH------SVSVVEVEETPFRRFLGERVGHTLMKMFENNRVKFYMQTEVSELRAQE-GKLKEVVLKSSKVVRADVCVVGIGAVPATGFLRQSGISLDSR- M_mulatta_ENSMMUP00000026974 GAGF----LGMEVAAYLTEKAH------SVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELRGQE-GKLKEVVLKSSKVVRADVCVVGIGAVAATGFLRQSGIGLDSR- T_nigroviridis_ENSTNIP00000019217 GTSF----VGMEIASYLIDKAS------SIAVIGSSEMPYQNTLGPEIGRVTMKMLAEKNVEFHMNDSVVEVRGQE-GKVKEVVLKSARVLLADVFIVGIGVKPNSEFLRGSGIQLDSR- T_nigroviridis_ENSTNIP00000018986 GTSF----VGMEVAAALTDKAH------SVSVIGIESVPFKQALGEKVGKAVMKLFEANRVKFYMMNEVSEMVGHH-GQLKEVVLNSGKVLRADVCVIGAGSVPATGFLKQSGIHMDSK- R_norvegicus_ENSRNOP00000048427 GAGF----LGMEVAAYLTEKAH------SVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELRAQE-GKLQEVVLKSSKVLRADVCVVGIGAVPATGFLRQSGIGLDSR- A_carolinensis_ENSACAP00000010903 GASF----LGMEVAAYLSDRAH------SVSVVELEEVPFKKFFGEKVGRALMKMFENNRVKFYMQTEVSELREQE-GKLKEVVLKSGKVLRADVCVIGIGATPATGFLKQSGVHVDSK- T_rubripes_ENSTRUP00000040932 GTSF----VGMEVAAALTDKAH------SVSVIGIESVPFKQALGEKVGKALMKLFEANRVKFYMMSEVSEMVGHH-GQLKEVVLNSGKVLRADVCVIRAGSVPATGFLKQSGINMDSK- M_musculus_ENSMUSP00000111349 GAGF----LGMEVAAYLTEKAH------SVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELRAQE-GKLQEVVLKSSKVLRADVCVLGIGAVPATGFLRQSGIGLDSR- O_latipes_ENSORLP00000010037 GASF----IGVEVAAYLSDKAA------GVALVGPTQYPFENTLGPEIGRICMQMLEERNVKFYMNSKVTEIRGEN-GKVKEVVLNNGTVLEADVVIAGIGAIPNSGFLAGTEIAVDSK- T_nigroviridis_ENSTNIP00000021125 GASF----IGMEVASYLSNKAA------SVAVVGTSSYPFQKSLGQEIGKMCMQMFEEKNVKFYMNDGVTEIRGNN-GKVKEVVLKSGTVLEADVVVAGIGVIPNTDFLSGSKLEMNSK- G_aculeatus_ENSGACP00000011210 GASFIGTTIGMEVASYLSNTAA------SVAVVGPSRYPYERSLGPQIGRMIMQMLEEKNVKFYMTDFVDEIKGEN-GKVKGVLLKSGIVLEADVVIAGIGVIPNSDFLTGSQLEVDSR- T_rubripes_ENSTRUP00000040612 GASF----IGMEVASYLSNKAA------SVTVVGTSSYPFQKSLGSEIGKMCMEMFEEQNVKFYMNDGVTEIRGNS-GKVKEVVLKS-TILEADVVVAGIGVIPNTDFLIGSKLEVDSR- G_aculeatus_ENSGACP00000027082 GTSF----VGMEVASYLVDKAS------SVTVIGSSELPYQNTLGREIGKVSMMMLTEQNVKFYMNENVTEIKGVD-GKVKEVVLKSGKVIPADVLIVGIGIKPNSEFLRGSKILTDSK- X_tropicalis_ENSXETP00000057179 GASF----LGMEVAAYLCEKAH------SVSVVELENIPFKKFLGEKVGLAIMKMFENNRVKFYMQTEVSELREQE-GKLKEVVLKSGKVLRADVCVIGIGASPTTGFLKQSGVALDSR- G_gallus_ENSGALP00000039047 GASF----IGMETAAFLSDKAA------AISVVEKQEFPFQKTLGPQVGGVVLKMLQSKGVKFYMKKELHELKGKD-GKVAEAILASGEKLPADVVVVGIGVTPNSAFLKGTSIAKDNS- O_latipes_ENSORLP00000003241 GTSF----VGMEVASYLLDKAS------SITVIGSSELPYQNTLGREVGRITMMMLSEYNIKFYMNDIVTEIKGVN-GKVKEVVLKSGKVIPTDVLIVGIGSIPNSAFLQGTKIQMNPK- A_carolinensis_ENSACAP00000014484 GGSF----IGMELASSLAGKAS------AIQVVERGHAPYHAVLGGQVGQVAMKMLQSQGVEFHLEAEVAELKGQE-GKVTHVILGSGHKIPADVVVVGIG------------------- T_rubripes_ENSTRUP00000030429 GTSF----VGMEIASYLIDKAS------SITVIGSSELPYQSTLGPEIGRVTMMMLTEKNVRFYMNDSVLEVRGQD-GKVKEVVLKSAKVLPADVFIVGIGVKPNSEFLRGSRIQLDSR- D_melanogaster_FBpp0080714 GSSF----MAVEATANLVSRAR------SVTLVARQNVPFKSTLGELIGQRILKLLEENKVDLRMSSGIIRILGNSRGEVVAVKLLDNSRIPCNLLILGTGCQCNTDFLQRSGININPN- A_aegypti_AAEL011158-PA GVSF----IGLEAAAYCVNKVA------KVTVIGRGAVPLVESFGEQVGSKVMQWFKEKGVHFIMNSGIKRCIGDDDRKLTSVELNDGTILKADLCIMGIGSTLFTTFLEGSGVKVNKG- D_melanogaster_FBpp0070319 GSSF----IALEAAAGLVSKVQ------SVTVVGRENVPLKAAFGAEIGQRVLQLFEDNKVVMRMESGIAEIVGNEDGKVSEVVLVDDTRLPCDLLILGTGSKLNTQFLAKSGVKVNRN- C_elegans_F20D6.11 GSSF----IGMEVASALAEKAA------SVTVISNTPEPL-PVFGSDIGKGIRLKFEEKGVKFELAANVVALRGNDQGEVSKVILENGKELDVDLLVCGIGVTPATKFLEGSGIKLDNR- 850 860 870 880 890 900 910 920 930 940 950 960 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ C_elegans_Y56A3A.32.1 GGVRAD--KCLKV---------GENVWAAGAIATFEDGVL--GARRVS--SWENAQISGRLAGENMATAAADGKSEGKAFWYQPSFFTK--FAPHLHINAIG------KCDSSLETVSVH T_rubripes_ENSTRUP00000030183 GGYRVN--AELQA---------RSNIWVAGDAACFYDIRL--GRRRVE--HHDHAVVSGRLAGENMTGAN-------KPYWHQSMFWSD--LGPDVGYEAIG------IVDSSLPTVGVF T_nigroviridis_ENSTNIP00000014785 GGYRVN--AELQA---------RSNIWVAGDAACFYDIRL--GRRRVE--HHDHAVVSGRLAGENMTGAN-------KPYWHQSMFWSD--LGPDVGYEAIG------IVDSSLPTVGVF C_intestinalis_ENSCINP00000012225 GGYRVN--AELQA---------RSNIWVAGDASCFFDAKL--GRRRVE--HHDHAVVSGRLAGENMAGGQ-------KSYYHQSMFWSD--LGPDVGYEAIG------IIDSALPTVGVF O_latipes_ENSORLP00000012070 GGYRVN--AELQA---------RSNIWVAGDAACFYDIRL--GRRRVE--HHDHAVVSGRLAGENMTGAS-------KPYWHQSMFWSD--LGPDVGYEAIG------IVDSSLPTVGVF H_sapiens_ENSP00000287295 GGFRVN--AELQA---------RSNIWVAGDAACFYDIKL--GRRRVE--HHDHAVVSGRLAGENMTGAA-------KPYWHQSMFWSD--LGPDVGYEAIG------LVDSSLPTVGVF X_tropicalis_ENSXETP00000039440 GGYRVN--AELQA---------RNNVWVAGDAACFYDIKL--GRRRVE--HHDHAVVSGRLAGENMTGAA-------KPYWHQSMFWSD--LGPEVGYEAIG------IVDSALPTVGVF T_guttata_ENSTGUP00000005365 GGFRVN--AELQA---------RSNIWVAGDAACFYDIKL--GRRRVE--HHDHAVVSGRLAGENMTGAA-------KPYWHQSMFWSD--LGPNVGYEAIG------LVDSSLPTVGVF P_pygmaeus_ENSPPYP00000023188 GGFRVN--AELQA---------RSNIWVAGDAACFYDIKL--GRRRVE--HHDHAVVSGRLAGENMTGAA-------KPYWHQSMFWSD--LGPDVGYEAIG------LVDSSLPTVGVF E_caballus_ENSECAP00000002768 GGFRVN--AELQA---------RSNIWVAGDAACFYDIKL--GRRRVE--HHDHAVVSGRLAGENMTGAA-------KPYWHQSMFWSD--LGPDVGYEAIG------LVDSSLPTVGVF A_carolinensis_ENSACAP00000008812 GGFRVN--AELQA---------RSNIWVAGDAACFYDIKL--GRRRVE--HHDHAVVSGRLAGENMTGAA-------KPYWHQSMFWSD--LGPDVGYEAIG------LVDSGLPTVGVF M_mulatta_ENSMMUP00000006568 GGFRVN--AELQA---------RSNIWVAGDAACFYDIKL--GRRRVE--HHDHAVVSGRLAGENMTGAA-------KPYWHQSMFWSD--LGPDVGYEAIG------LVDSSLPTVGVF G_aculeatus_ENSGACP00000026857 GGFRVN--AELQA---------RSNIWVAGDAACFYDIRL--GRRRVE--HHDHAVVSGRLAGENMTGAN-------KPYWHQSMFWSD--LGPDVGYEAIG------IVDSSLPTVGVF D_rerio_ENSDARP00000075330 GGYRVN--AELQA---------RSNIWVAGDAACFYDIKL--GRRRVE--HHDHAVVSGRLAGENMTGAN-------KPYWHQSMFWSD--LGPDVGYEAIG------IVDSSLPTVGVF R_norvegicus_ENSRNOP00000008503 GGFRVN--AELQA---------RSNIWVAGDAACFYDIKL--GRRRVE--HHDHAVVSGRLAGENMTGAA-------KPYWHQSMFWSD--LGPDVGYEAIG------LVDSSLPTVGVF M_musculus_ENSMUSP00000041104 GGFRVN--AELQA---------RSNIWVAGDAACFYDIKL--GRRRVE--HHDHAVVSGRLAGENMTGAA-------KPYWHQSMFWSD--LGPDVGYEAIG------LVDSSLPTVGVF B_taurus_ENSBTAP00000008987 GGFRVN--AELQA---------RSNIWVAGDAACFYDIKL--GRRRVE--HHDHAVVSGRLAGENMTGAA-------KPYWHQSMFWSD--LGPDVGYEAIG------LVDSSLPTVGVF C_familiaris_ENSCAFP00000027660 GGFRVN--AELQA---------RSNIWVAGDAACFYDIKL--GRRRVE--HHDHAVVSGRLAGENMTGAA-------KPYWHQSMFWSD--LGPDVGYEAIG------LVDSSLPTVGVF A_gambiae_AGAP008044-PA GGFLVD--AELRA---------RSNVFVAGDAACFYDTKF--GRRRVE--HHDHAIVSGRLAGENMVGLN-------KPYTHQSMFWSD--LGPRISYEAIG------LIDSSLPTVAVF G_gallus_ENSGALP00000006366 GGFRVN--AELQA---------RSNIWVAGDAACFYDIKL--GRRRVE--HHDHAVVSGRLAGENMTGAA-------KPYWHQSMFWSD--LGPDVGYEAIG------LVDSTLPTVGVF A_aegypti_AAEL002016-PA GGFVVD--AELRA---------RSHLYVAGDAACFFDPKL--GRRRVE--HHDHAVVSGRLAGENMVGLN-------KPYTHQSMFWSD--LGPKIGYEAIG------IIDSALPTVAVF D_melanogaster_FBpp0077504 GGFVVN--AELEA---------RRNLYVAGDASCFFDPLL--GRRRVE--HHDHSVVSGRLAGENMTGAK-------KPYQHQSMFWSD--LGPEIGYEGIG------LVDSSLPTVGVF M_domestica_ENSMODP00000027578 GGFRVN--AELQA---------RSNIWVAGDAACFYDIKL--GRRRVE--HHDHAVVSGRLAGENMTGAA-------KPYWHQSMFWSD--LGPDVGYEAIG------LVDGSLPTVGVF O_cuniculus_ENSOCUP00000002538 GGFRVN--AELQA---------RSNIWVAGDAACFYDIKL--GRRRVE--HHDHAVVSGRLAGENMTGAA-------KPYWHQSMFWSD--LGPDVGYEAIG------LVDSSLPTVGVF P_troglodytes_ENSPTRP00000038338 GGFRVN--AELQA---------RSNIWV-----------------------------------------------------------SD--LGPDVGYEAIG------LVDSSLPTVGVF T_guttata_ENSTGUP00000016816 GGFRVN--AELQA---------RSNIWV-------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000007470 GGFRVN--AELQA---------RSNIWVXXXXXXXXXXXX--XXXXXX--XXXXXXXXXXXXXXXXXXXX-------XXXXXXXXXXSD--LGPDVGYEAIG------LVDSSLPTVGVF C_intestinalis_ENSCINP00000015763 GFVGVD--RHMRALKSSGDGEIFENIYAAGDIAINMLVHPQWDWQPSNIQHWQMAHYHGRVAGTNMVVPNDEL----QSVESVPFFWTQ-QYGKSLRYTGYGVGYDDIVIKGEVSEGKFC D_rerio_ENSDARP00000085557 GFIPVN--KTMQT--------NIDGVFAGGDVVTFPLALR--SNKKVNIPHWQMAHVHGRLAALGIMGKA-------SDIKTVPYFWTA-MFGKSIRYAGYGDGFDDVVIQGDLDELKFV O_latipes_ENSORLP00000009976 GFITVN--KMMQT--------NVEGVFAGGDVVTFPFPQR--NNKKVNIPHWQMAHVHGRVAALSMMGRA-------SEAKTVPYFWSA-MFGKTIRYAGYGDGFDDVIIQGDLDELRFV G_gallus_ENSGALP00000012503 GFIVVN--KMMQT--------NIPGVFAAGDAVTFPLALR--NNKKVNVPHWQMAHMHGRIAALNMLAHG-------TEISTVPYLWTA-MFGKSIRYAGHGEGFDDVVIQGDLDELKFV P_pygmaeus_ENSPPYP00000013415 GFIPVN--KMMQT--------NVPGVFAAGDAVTFPLAWR--NNRKVNIPHWQMAHAQGRVAAQNMLAQE-------AEMSTVPYLWTA-MFGKSLRYAGYGEGFDDVIIQGDLEELKFV T_guttata_ENSTGUP00000010972 GFIVVN--KMMQT--------NIPGVFAAGDAVTFPLALR--NNKKVNVPHWQMAHMHGRIAALNMLAHG-------TEISTVPYLWTA-MFGKSIRYAGHGEGFDDVVIQGDLDELKFV P_troglodytes_ENSPTRP00000024275 GFIPVN--KMMQT--------NVPGVFAAGDAVTFPLAWR--NNRKVNIPHWQMAHAQGRVAAQNMLAQE-------AEMTTVPYLWTA-MFGKSLRYAGYGEGFDDVIIQGDLEELKFV H_sapiens_ENSP00000382120 GFIPVN--KMMQT--------NVPGVFAAGDAVTFPLAWR--NNRKVNIPHWQMAHAQGRVAAQNMLAQE-------AEMSTVPYLWTA-MFGKSLRYAGYGEGFDDVIIQGDLEELKFV G_aculeatus_ENSGACP00000012379 GFITVN--KMMQT--------NADGVFAGGDVVVFPFPPR--HNKKVNIPHWQMAHVHGRVAALGMMGRP-------ADLKTVPYFWSA-MFGKTIRYAGYGDGFDDVIIQGDLDELRFV B_taurus_ENSBTAP00000053272 GFIPVN--KMMQT--------NIPGVFAAGDAVTFPLAWR--NNRKVNIPHWQMAHAQGRVAAQNMLAQE-------AEISTVPFLWTA-MFGKSLRYAGYGEGFDDVIIQGDLDELKFV M_mulatta_ENSMMUP00000026974 GFIPVN--KMMQT--------NVPGVFAAGDAVTFPLAWR--NNRKVNIPHWQMAHAQGRVAAQNMLAQE-------AEMNTVPYLWTA-MFGKSLRYAGYGEGFDDVIIQGDLEELKFV T_nigroviridis_ENSTNIP00000019217 NFVMVD--KYMRT--------NMPGVFCGGDVATFPLTMA--KNRPVHIGHWQMAQAHGRIAALNMLEKP-------TELSSVPFYWTV-LLGKTIRYAGYGEGYTEIVVKGRLEDKKFL T_nigroviridis_ENSTNIP00000018986 GFITVN--KTMQT--------NVEGVFAGGDAVIFPFPPR--NNKKVNIPHWQMAHVHGRVAALGMLGRA-------ADIKTVPFFWSA-MFGKTLRYAGYGDGFDDVIIQGDLDELKFV R_norvegicus_ENSRNOP00000048427 GFIPVN--KMMQT--------NIPGVFAAGDAVTFPLAWR--NNRKVNIPHWQMAHAQGRVAAQNMLAQE-------AEINTVPYLWTA-MFGKSLRYAGYGEGFDDVIIQGDLEELKFV A_carolinensis_ENSACAP00000010903 GFIAVN--KMMQT--------SIPGVFAAGDAVAFPLSLR--NNKKVNIPHWQMAHMHGRIAALNMLAHG-------TEISTVPYLWTA-MFGKSIRYAGHGEGFDDVIIRGDLDELKFV T_rubripes_ENSTRUP00000040932 GFITVN--KMMQT--------SADGVFAGGDAVTFPFPPR--NNKKVNIPHWQMAHVHGRMAALSMMDRA-------ADIKTVPFFWSA-MFGKTLRYAGYGDGFDDVIIQGDLDELRFV M_musculus_ENSMUSP00000111349 GFIPVN--KMMQT--------NVPGVFAAGDAVTFPLAWR--NNRKVNIPHWQMAHAQGRVAAQNMLAQE-------AEINTVPYLWTA-MFGKSLRYAGYGEGFDDVIIQGDLEELKFV O_latipes_ENSORLP00000010037 KAVIVD--KFMRT--------NTPDIFAAGDVTSFPLTIR--GGEQVSIGHWQMSHAHGKIAGLNMMKKP-------TPIESVPFFWTT-FLGKGIRYTGYGEGYTEIIFKGKVEERKFL T_nigroviridis_ENSTNIP00000021125 NTLVVD--KFMRT--------NVPDIFSAGDVTSFPLTIR--GDEVVNIGHWQMSQAQGRVAALNMLKKP-------TKFESVPFFWTV-LLGKSIRYTGYGEGYTEIIYKGNVEERKFL G_aculeatus_ENSGACP00000011210 KAVIVD--KFMRT--------NIPDIFSAGDVTSFPLTIR--GDQRVNVGHWQMSQAQGRVAALNMLKKP-------TKCESVPFFWTV-LLGKSIRYTGYGEGYTEILFKGKVEERKFL T_rubripes_ENSTRUP00000040612 KTLVVD--KFMKT--------NVPDIFSAGDVTSFPLSIC--GDKMVNIGHWQMSQAQGRVAALNMLKKP-------TEFQSVPFFWTV-LLGKSIRYTGYGEGYTEIIYKGSIQERKFL G_aculeatus_ENSGACP00000027082 NFVPVD--RYMRT--------NVPGVFCGGDLATFPLAMA--KNRPVNIGHWQMAQAHGRIAALNMLDKQ-------IELSSVPFYWTV-LLGKTIRYTGFGEGYTDIVMKGALEDRKFL X_tropicalis_ENSXETP00000057179 GYILVN--KMMQT--------NIPGVFAAGDVVTFPLAFR--NNKKVNVPHWQMAHMQGRIAALNMLAQG-------TEINTVPYLWTA-MFGKSIRYAGHGDGFDDVIIQGDIDELKFV G_gallus_ENSGALP00000039047 GAILVD--LRMQT--------NIPNVFAAGDVVSFPVALL--NGDHSSIHHQQVAEAHGSIAAFNMLKKQ-------KELHTVPFFWTT-MLGRSIHYAGCGKGYTDTVLKGSLEEQKFL O_latipes_ENSORLP00000003241 KLVIVD--KYMRT--------NVPDVFCAGDLATFPLAMA--KNQLVNIGHWQMAQAQGRVAALNMLGKE-------TELTSVPFYWTV-LLGKTIRYAGYGEGYTELVMKGNIQEHKFL A_carolinensis_ENSACAP00000014484 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000030429 NFVVVDKPKYMRT--------NIPGVFCGGDVATFPLTMA--KNQPVNIGHWQMAQAHGRTAALNMLDKP-------TELSSVPFYWTV-LLGKTIRYAGYGEGYTEIVVKGKLEDKKFL D_melanogaster_FBpp0080714 GSVDVN--DFLQT--------KVRNVYVGGDIANAYILGG--FPDRVNISHYGLAQYHGRIAALNMSGHI-------AKLEAIPFFYTV-IFGRAFRSAGYGP-FKDVVIDGSLEDLQFV A_aegypti_AAEL011158-PA GSVDTN--RFLET--------NVPGIYAGGDIAHAPVFCN--NNEPATIGHYPLAQYHGKVAALNMVGKA-------TELKSVPYFWTM-LFGKGFRYAGYGRPH-ETIIEGDLEQLKFV D_melanogaster_FBpp0070319 GSVDVT--DFLES--------NVPDVYVGGDIANAHIHGL--AHDRVNIGHYQLAQYHGRVAAINMCGGV-------KKLEAVPFFFTL-IFGKGIRYAGHGS-YKDVIIDGSMEDFKFV C_elegans_F20D6.11 GFIEVD--EKFRT--------NISYIFAMGDVVTAPLPLW--DIDSINIQHFQTAQAHGQHLGYTIVGKP-------QPGPIVPYFWTLFFFAFGLKFSGCNQGSTKEYTNGDPETGTFI 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ C_elegans_Y56A3A.32.1 AEP---DKDTP------------------------------------------------------------LEKAVVFYKSKEDGSIVGVLLLNVFGPSLDVARRIIDDRKKVDEYKEIA T_rubripes_ENSTRUP00000030183 AKAT--EKDTPKAATEK-----SGTGIRSE-SETEETAASTE--------PSSSPAPAPAPEKQK----DDYGKGVIFY--LRDKVVVGIILWNVFN-RMPIARKIIKDGEEHADLNEVA T_nigroviridis_ENSTNIP00000014785 AKAT--EKDTPKAATEK-----SGTGIRSE-SETEETATSTE--------SSSSPAPAPE--KPK----DDYGKGVIFY--LRDKVVVGIILWNVFN-RMPIARKIIKDGEEHADLNEVA C_intestinalis_ENSCINP00000012225 AKAT--EKDTPKAA--------EGAGLRDDGAENPAENTE-------------KQPTTTTTTASS----EEFGKGVVFY--LRQQKVVGVLLWNVFG-RMPIARKMIRDQQAYDDYTEVA O_latipes_ENSORLP00000012070 AKAT--AKDTPKAATEM-----SGTGIRSE-SETEDTAVS----------PVASDTPSPA-AENK----DDFGKGVIFY--LRDKVVVGIILWNVFN-RMPIARKIIKDGEEHADLNEVA H_sapiens_ENSP00000287295 AKAT--AQDNPKSATEQ-----SGTGIRSE-SETESEASEIT--------IPPSTPAVPQAPVQG----EDYGKGVIFY--LRDKVVVGIVLWNIFN-RMPIARKIIKDGEQHEDLNEVA X_tropicalis_ENSXETP00000039440 AKAT--EKDTPKRAAEE-----SGTGIRSE-SEVAETGPVEE-----VKPPASSSEFAPS--QQG----DNYGKGVVFY--LRDNVVVGMVLWNIFN-RMPIARKIIKDGEQHSDLNEVA T_guttata_ENSTGUP00000005365 AKAT--AKDTPKSATEQ-----SGTGIRSE-SETEAEASEVQ--------ISQSSSPMPQVPKQG----EDYGKGVIFY--LRDKVVVGIVLWNIFN-RMPIARKIIKDGEEHEDLNEVA P_pygmaeus_ENSPPYP00000023188 AKAT--AQDNPKSATEQ-----SGTGIRSE-SETESEASEIT--------IPPSTPAVPQAPVQG----EDYGKGVIFY--LRDKVVVGIVLWNIFN-RMPIARKIIKDGEQHEDLNEVA E_caballus_ENSECAP00000002768 AKAT--AQDNPKSATEQ-----SGTGIRSE-SETESEASEIA--------IPSGNPAVPQAPTQG----EDYGKGVIFY--LRDKVVVGIVLWNIFN-RMPIARKIIKDGEQHEDLNEVA A_carolinensis_ENSACAP00000008812 AKAT--ARDTPKSATEE-----SGTGIRSE-SETEMEASELK--------VSAASPSSLQAPQQG----EDYGKGVIFY--LRDKVVVGIVLWNIFN-RMPIARKIIKDGEGHTDLNEVA M_mulatta_ENSMMUP00000006568 AKAT--AQDNPRSATEQ-----SGTGIRSE-SETESEASEIA--------IPPSTPAVPQAPVQG----EDYGKGVIFY--LRDKVVVGIVLWNIFN-RMPIARKIIKDGEQHEDLNEVA G_aculeatus_ENSGACP00000026857 AKAT--AKDTPKAATEE-----SGTGIRSE-SETEHTASS----------PVASSAPSPTGVQHK----DEYGKGVIFY--LRDKVVVGIILWNVFN-RMPIARKIIKDGEEHADLNEVA D_rerio_ENSDARP00000075330 AKAT--AKDTPKAATEQ-----SGTGIRSE-SETEAVAGVLE--------VGTVTPAPPV--QQK----EDYGKGIIFY--LRDKVVVGIVLWNVFN-RMPIARKIIKDGEAHTDLNEVA R_norvegicus_ENSRNOP00000008503 AKAT--AQDNPKSATEQ-----SGTGIRSE-SETESEASEIT--------IPPSDPAVPQVPVEG----EDYGKGVIFY--LRDKVVVGIVLWNVFN-RMPIARKIIKDGEQHEDLNEVA M_musculus_ENSMUSP00000041104 AKAT--AQDNPKSATEQ-----SGTGIRSE-SETESEASEIT--------IPPSAPAVPQVPVEG----EDYGKGVIFY--LRDKVVVGIVLWNVFN-RMPIARKIIKDGEQHEDLNEVA B_taurus_ENSBTAP00000008987 AKAT--AQDNPKSATEQ-----SGTGIRSE-SETESEASDIP--------VPPSNPAVPQVPTQG----EDYGKGVIFY--LRDKVVVGIVLWNIFN-RMPIARKIIKDGEQHEDLNEVA C_familiaris_ENSCAFP00000027660 AKAT--AQDNPKSATEQ-----SGTGIRSE-SETESEASEIA--------VPPSNPAVPQTPAQG----EDYGKGVIFY--LRDKVVVGIVLWNIFN-RMPIARKIIKDGEQHEDLNEVA A_gambiae_AGAP008044-PA AKRT--AEEMSRASAAA-----AAAVTAGS-TDSEKLQAANANVNVDVKNVPAAGEPAKEQSKEQQEPEDSFDKGVIFY--LRDKKVVGLVLWNVFN-RMGTARKILDQHTEYDDLNEVA G_gallus_ENSGALP00000006366 AKAT--AKDTPKSATEQ-----SGTGIRSE-SETEAEASEVP--------ISPSSSPTPQVPKEG----EDYGKGVIFY--LRDKVVVGIVLWNIFN-RMPIARKIIKDGEEHADLNEVA A_aegypti_AAEL002016-PA AKST--PPQTIPDTSEKLQAANASVTPANS-NGGESSSSVLSNPNV----VKAEQKPAPPAEEDQ----EDFNKGVIFY--LKDEKVVGVLLWNVFN-RIGTARRIVAQHTRYDDLNEVA D_melanogaster_FBpp0077504 ALPS--ESATRVDQLSE-----SSDSDVPETSTSSSQSSKSD--------AGASQDGVTCDPDEA----GNYGKGVIFY--LKNDKIVGILLWNLFN-RIGLARTIINQNKKYDDLNEVA M_domestica_ENSMODP00000027578 AKAT--AKDTPKSATEQ-----SGTGIRSE-SETESEASDID--------IPPSDAKTPQSLIKG----EDFGKGVIFY--LRDKVVVGILLWNIFN-RMPIARKIIKDGEEHEDLNEVA O_cuniculus_ENSOCUP00000002538 AKAT--AQDSPKSATEQ-----SGTGIRXX-XXXXXXXXXXX--------XXXXXXXXXXXXXXX----XXXXXXXXXX--XXXXXXXXXXXXXXXX-XXXXXXXIIKDGEQHEDLNEVA P_troglodytes_ENSPTRP00000038338 AKAT--AQDNPRSATEQ-----SGTGIRSE-SETESEASEIT--------IPPSTPAVPQAPIQG----EDYGKGVIFY--LRDKVVVGIVLWNIFN-RMPIARK--------------- T_guttata_ENSTGUP00000016816 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000007470 AKAT--AQDNPKSATEQ-----SGTGIRSE-SETESEASEIT--------IPPSTPAVPQAPVQG----EDYGKGVIFY--LRDKVVVGIVLWNIFN-RMPIARK--------------- C_intestinalis_ENSCINP00000015763 AYYT--CKDQIVAIATM-----NSDPVAADFA-------------------------------------QRMLSGKAL------------------------------------------ D_rerio_ENSDARP00000085557 AFYT--KSEEVVAVASM-----NYDPIVSRVA-------------------------------------EVFGSGKTIR-------------------KRDVE----------TG--DMS O_latipes_ENSORLP00000009976 AFYT--RSEEVVAVASM-----NYDPIVSRVV-------------------------------------EVLGSGKTIK-------------------KRDVEM--LARL-GKTG--DIS G_gallus_ENSGALP00000012503 AFYT--K----------------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000013415 AFYT--KGDEVIA-ASM-----NYDPIVS-VA-------------------------------------EVLAS-RAIR-------------------KR-VEL--FVLH-SKTG--DMS T_guttata_ENSTGUP00000010972 AFYT--KSDEVVAVASM-----NYDPIVSKVA-------------------------------------EVLAAGRTIR-------------------KRDVDTVDFLSF--RTG--DMS P_troglodytes_ENSPTRP00000024275 AFYT--KGDEVIAVASM-----NYDPIVSKVA-------------------------------------EVLASGRAIR-------------------KREVEL--FVLH-SKTG--DMS H_sapiens_ENSP00000382120 AFYT--KGDEVIAVASM-----NYDPIVSKVA-------------------------------------EVLASGRAIR-------------------KREVEL--FVLH-SKTG--DMS G_aculeatus_ENSGACP00000012379 AFYT--RGEEVVAVASM-----NYDPIVSRVA-------------------------------------EVLGSGKTIR-------------------KRDVEI--LARL-GKTG--DIS B_taurus_ENSBTAP00000053272 AFYT--KGDEVISVASM-----NYDPIVSKVA-------------------------------------EVLASGRTIR-------------------KREVEL--FVLH-SKTG--DMS M_mulatta_ENSMMUP00000026974 AFYT--KGDEVIAVASM-----NYDPIVSKVA-------------------------------------EVLASGRAIR-------------------KREVEL--FVLH-SKTG--DMS T_nigroviridis_ENSTNIP00000019217 VLYI--KDDAVVAAGSL-----NYDPAVSAVA-------------------------------------QRLMAGKVIT-------------------KEEAQ----------------- T_nigroviridis_ENSTNIP00000018986 AFYT--RSEEVVAVASM-----NYDPIVSRVA-------------------------------------EVLGSGKTIK-------------------KRDVDL--ASMSTSRTG--DIS R_norvegicus_ENSRNOP00000048427 AFYT--KGDEVIAVASM-----NYDPIVSKVA-------------------------------------EVLASGRAIR-------------------KREVEL--FMLH-SKTG--DMS A_carolinensis_ENSACAP00000010903 AFYT--KNDEVVAVASM-----NYDPLVSKVA-------------------------------------DVMGAGRTIR-------------------KRDVEL--FIRY-GKIG--DMS T_rubripes_ENSTRUP00000040932 AFYT--RSEEVVAVASM-----NYDPIVSRVA-------------------------------------EVLGSGKTIK-------------------KRDVEK--LVTLITWTG--DIS M_musculus_ENSMUSP00000111349 AFYT--KSDEVIAVASM-----NYDPIVSKVA-------------------------------------EVLASGRAIR-------------------KREVEL--FMLH-SKTG--DMS O_latipes_ENSORLP00000010037 AFYI--KKDVVVAAASM-----TFDPAVAQVA-------------------------------------ELMSKGNIIT-------------------KAQAH----------PELYGMY T_nigroviridis_ENSTNIP00000021125 AFYI--KDEKVVAAASL-----MFDPAVARLA-------------------------------------ELMTSGQVIT-------------------KTQAHL--FVCV-CRAQ--DLA G_aculeatus_ENSGACP00000011210 AFYI--KDEVVVAAASL-----MFDPAVARVA-------------------------------------ELMATGQVIS-------------------KAQAQ----------AD--DLS T_rubripes_ENSTRUP00000040612 AFYI--KEEKVVAAASL-----MFDPAVARLA-------------------------------------ELMASGQTIT-------------------KTQAQ---FPCV-FRAP--DLA G_aculeatus_ENSGACP00000027082 ALYI--KNDEVVAAASL-----NYDPAASAVA-------------------------------------ERFAAGKVIT-------------------KKEAEY--AVFD-ARWG--GAS X_tropicalis_ENSXETP00000057179 AFYT--RNDEVIAVASM-----NYDPIVSKVA-------------------------------------EIMSSGKTIR-------------------KRDVEI--FVCH-GKTG--DIS G_gallus_ENSGALP00000039047 IFYL--KD---------------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000003241 ALYLNWRNDEVIAAAGL-----NFDPAVSAVA-------------------------------------ERLSSGKVIT-------------------KKEAQY--YVFD-GKTE--SAA A_carolinensis_ENSACAP00000014484 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000030429 ALYI--KNDAVIAAVSL-----NYDPAVSAVA-------------------------------------QRLIAGKVIT-------------------KEEAQL--CSVS-SK-T--QAN D_melanogaster_FBpp0080714 AYFFD-DYDKVTAVASC-----GRDPMVAQFA-------------------------------------ELVSQGKELC-------------------RCQIVDPKGRNY---------- A_aegypti_AAEL011158-PA AFYLD-ANGKVIGMASC-----GRDPVVSQFA-------------------------------------EYLSQGKTFH-------------------KDQLSPD------------PFA D_melanogaster_FBpp0070319 AYFIN-EADTVTAVASC-----GRDPIVAQFA-------------------------------------ELISQGKCLG-------------------RGQIEDPATRED---------- C_elegans_F20D6.11 RYFL--KKDKVVAVAAG-----GPSSVASQFA-------------------------------------EIFKKGIEVT-------------------LKDLKNSS-----------DHT 1090 1100 =========+========== C_elegans_Y56A3A.32.1 KLFPLYDPVKSDEDDAKSA- T_rubripes_ENSTRUP00000030183 KLFNIHED------------ T_nigroviridis_ENSTNIP00000014785 KLFNIHED------------ C_intestinalis_ENSCINP00000012225 KLFKIHSEELD--------- O_latipes_ENSORLP00000012070 KLFNIHED------------ H_sapiens_ENSP00000287295 KLFNIHED------------ X_tropicalis_ENSXETP00000039440 KLFNIHEE------------ T_guttata_ENSTGUP00000005365 KLFNIHEE------------ P_pygmaeus_ENSPPYP00000023188 KLFNIHED------------ E_caballus_ENSECAP00000002768 KLFNIHED------------ A_carolinensis_ENSACAP00000008812 KLFNIHED------------ M_mulatta_ENSMMUP00000006568 KLFNIHED------------ G_aculeatus_ENSGACP00000026857 KLFNIHDD------------ D_rerio_ENSDARP00000075330 KLFNIHED------------ R_norvegicus_ENSRNOP00000008503 KLFNIHED------------ M_musculus_ENSMUSP00000041104 KLFNIHED------------ B_taurus_ENSBTAP00000008987 KLFNIHED------------ C_familiaris_ENSCAFP00000027660 KLFNIHED------------ A_gambiae_AGAP008044-PA KLFNLHDRRTESEELEAAEQ G_gallus_ENSGALP00000006366 KLFNIHED------------ A_aegypti_AAEL002016-PA KLFNLHERPEEPEAEEKEQ- D_melanogaster_FBpp0077504 KLFEIHA------------- M_domestica_ENSMODP00000027578 KLFNIHED------------ O_cuniculus_ENSOCUP00000002538 KLFNIHED------------ P_troglodytes_ENSPTRP00000038338 -------------------- T_guttata_ENSTGUP00000016816 -------------------- G_gorilla_ENSGGOP00000007470 -------------------- C_intestinalis_ENSCINP00000015763 -------------------- D_rerio_ENSDARP00000085557 WLIVKGSQ------------ O_latipes_ENSORLP00000009976 WLIDKGF------------- G_gallus_ENSGALP00000012503 -------------------- P_pygmaeus_ENSPPYP00000013415 WLTGKGS------------- T_guttata_ENSTGUP00000010972 WLTGKGT------------- P_troglodytes_ENSPTRP00000024275 WLTGKGS------------- H_sapiens_ENSP00000382120 WLTGKGS------------- G_aculeatus_ENSGACP00000012379 WLIDKGP------------- B_taurus_ENSBTAP00000053272 WLTGKGS------------- M_mulatta_ENSMMUP00000026974 WLTGKGS------------- T_nigroviridis_ENSTNIP00000019217 -------------------- T_nigroviridis_ENSTNIP00000018986 WLIDKGS------------- R_norvegicus_ENSRNOP00000048427 WLTGKGS------------- A_carolinensis_ENSACAP00000010903 WLTGKGS------------- T_rubripes_ENSTRUP00000040932 WLIDKGS------------- M_musculus_ENSMUSP00000111349 WLTGKGS------------- O_latipes_ENSORLP00000010037 VLTGRRE------------- T_nigroviridis_ENSTNIP00000021125 WLQMKSS------------- G_aculeatus_ENSGACP00000011210 WLQMNYS------------- T_rubripes_ENSTRUP00000040612 WLLIEGA------------- G_aculeatus_ENSGACP00000027082 WKQPKWP------------- X_tropicalis_ENSXETP00000057179 WLTGKGS------------- G_gallus_ENSGALP00000039047 -------------------- O_latipes_ENSORLP00000003241 SVNRSAS------------- A_carolinensis_ENSACAP00000014484 -------------------- T_rubripes_ENSTRUP00000030429 LMATGGS------------- D_melanogaster_FBpp0080714 WLTKLKL------------- A_aegypti_AAEL011158-PA WIK----------------- D_melanogaster_FBpp0070319 WTKKLGQPLPQVR------- C_elegans_F20D6.11 WGHLLL--------------