>D_melanogaster_FBpp0071136 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MQRVQADQKPARM HQHAHTHSHAHSLQHAEEKEHNSNEMTTNLSSTGRIAASSSATPSAAAGGGASGAPTPPK SLALNQNHHYAPGSDTSGEQEEELLDSRYECAICIDWLNEPVL-TSCGHRFCRSCLTAWM -----------QKNNQCCPMDN----------KRLSAEHDIFPDNYTRREIEQLKRDCPN ---------------SSLGCSVVASPIELH--RH--LPSCPYRRQQEP------------ -----------------------------------------Q------------------ -------------------------EEKCP-FAKIKCDFVG--RPETNQLEEHLKADMPH HMQLML--QAFQQTAIATWQPHKPST--SGAAVENGHGQQQLPPPPQY------------ ------------------------------------------ANGVDE----QIVQT--- ---------------MYQRIVVLEQR---------------------------------- -------------------------------TREQ-----E------------------- ------------------------------------------------------------ ------------TRLENMQKQLRLARQQ-APVDPRY---------------SNGTIVWRI E-QLGALVARLRAN-----AN--NQVYSHECYTSPH-GYKF-------CARLNIQ----- ------------PRKPHVLSLHV---HLMQ-----------SENDYHL-----D-WPFKG R---IKLCMVHPAD----AT-LSQHDTIMTKPEILA-FHKP------------REAISTR GFGFLE-------------------YANISNIIQL---G--FCADDRLLIKIEINIV--- ------------------------------------------- >A_gambiae_AGAP003004-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------FLQSAAKADDGVLEARYECPICYCWLNEPIL-TKCGHRFCRKCITDWL -----------NEKNSNCPLDN----------EPLDIKCDIFPDNCTRREISQIKKPCPN ---------------SMRGCGEQLSPTDID--TH--LRQCPFAMSR-------------- -----------------------------------------Q------------------ -------------------------SQPCP-FARVKCKFVA---PDEAAMSAHIASDCQQ HLQVAR--SPCVSALTVTKFEFSPFTICSYCSRRGSNDRYKFWDPPA------------- ------------------------------------------KNSVPEMSTNELVRS--- ---------------MYERIVILEQE---------------------------------- -------------------------------VHIL-----G------------------- ------------------------------------------------------------ ------------IKLSKQEIQLTKLNQE---VDPRY---------------SGGVLLWKL D-DFSNKIESMVAN-----SN--CMFYSSEAYTSPH-GYKF-------CARINVS----- ------------PRTKDSIGLHV---HLMQ-----------SENDYHL-----E-WPFKG R---IKITLLNVRS----PE-LSQHDTIMSKPEILA-FHRP------------NQDISPR GFGFLE-------------------FAKIKDILAK------FADNNTVVIKIQMNIV--- ------------------------------------------- >M_domestica_ENSMODP00000024756 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MSLLNCEDSCGTSHPESDCCAGV-ASACSTGTKDD--SVNGST-- IP-GNLPSSLREEIQGYDVEFDPPLESKYECPICLMALREAVQ-TPCGHRFCKACIVKSI -----------RDAGHKCPVDN----------AILL-ETQLFPDNFAKREILSLTVKCPN -----------------EGCLLKMELRHLE--DH--QTHCEFALAECP-------QCHLP FRKYLLHN----HMVVECP---RRQVSCVNCAAPMPFEEK-EAKFHDQ-NCPLATVFCEY -CS---TMLIREQMPNHYDIDCPVAPIPCT-FSTFGCRE-K---MPRNHLARHLQEDTLA HMRMMA--QAIENISIAAFNPK-----LHQREASSYDTSP-------------------- --------------------LPRTP-----------------YPGPQNFQ--ETIQQ--- ---------------LESRLVIQDHQ--------------------------------IR ELTAK--------------------------METQ-----S------------------- ------------------------------------------------------------ ------------ACVGDLKRTIRTLEDRIAEMEAQQ---------------CNGIYIWKI N-NFGMHLKSQEEE-----KP--VVIHSPGFYTGKP-GYKL-------CMRLHLQ----- --------LPSAQRCANYISLFV---HTMQ-----------GEYDSHL-----P-WPFQG T---IRLTILDQSEAP--VR-QNHEEIMDAKPELLA-FQRP------------TIPRNPK GFGYVT-------------------FMHLQALKQR---T--FIKDDTLLVRCEVLTRLDM NSLRREG--FQPRSTDAGV------------------------ >O_anatinus_ENSOANP00000018657 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MSLLNCENSCGASQSEGDCCAAM-ASACSAGAKDD--SVSSSV-- NT-GNLHNSFMAETQGYDVEFDPPLESKYECPICLMALREAVQ-TPCGHRFCKACIVKSI -----------RDAGHKCPVDN----------EILL-ENQLFPDNFAKREILSLMVRCPN -----------------EGCLMKMELRQLE--EH--QSLCDYALVECP-------QCHIS FQKNILHD----HVVSECP---RRQVSCVNCALSMAFEDK-E--YHDQ-NCPLASVFCEY -CS---TVLIREQMPTHYDMDCPTAPIPCT-FSSFGCRE-K---MQRNQLARHLQDDTQA HMRMMA--QALHSISITALTP------VPQLDVLPFDPAS-------------------- --------------------LPRSSSGYDC------------HPEVQNFQ--ETIQQ--- ---------------LEGRLVRQDHQ--------------------------------IR ELIAK--------------------------METQ-----S------------------- ------------------------------------------------------------ ------------SHVVDLKRTIRTLEDKIAEMEAQQ---------------CNGIYIWKI G-NFGMHLKSQEEE-----KP--VVIHSPGFYTGKP-GYKL-------CMRLHLQ----- --------LPNAQRCANYISLFV---HTMQ-----------GEYDSHL-----P-WPFQG T---IRLTILDQSEAP--VR-QNHEEIMDTKPELLA-FQRP------------TIHRNPK GFGYVT-------------------FMHLQALRQR---A--FIKDDTLLVRCEVSTRFDM SSPRREG--FQPRSTDPGV------------------------ >R_norvegicus_ENSRNOP00000006148 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MSLLNCENSCASSQSSSDCCAAM-ANSCSAAMKDD--SVSGCV-- ST-GNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQ-TPCGHRFCKACITKSI -----------RDAGHKCPVDN----------EILL-ENQLFPDNFAKREILSLTVKCPN -----------------KGCVQKMELRHLE--DH--QVHCEFALVICP-------QCQRF FQKCQINK----HIIEDCP---RRQVSCVNCAVPMPYEEK-E--IHDQ-SCPLANIICEY -CG---TILIREQMPNHYDLDCPTAPVPCT-FSVFGCHE-K---MQRNHLARHLQENTQL HMRLLA--QAVHNVNL-SLRP--------------CDASS-------------------- -----------------------PSRG--C------------RPEDPNYE--ETVKQ--- ---------------LEGRLVRQDHQ--------------------------------IR ELTAK--------------------------METQ-----S------------------- ------------------------------------------------------------ ------------MHVSELKRTIRSLEDKVAEMEAQQ---------------CNGIYIWKI G-NFGMHLKSQEEE-----RP--VVIHSPGFYTGRP-GYKL-------CMRLHLQ----- --------LPTAQRCANYISLFV---HTMQ-----------GEYDSHL-----P-WPFQG T---IRLTILDQSEAV--IR-QNHEEVMDAKPELLA-FQRP------------TIPRNPK GFGYVT-------------------FMHLEALRQG---T--FIKDDTLLVRCEVSTRFDM GGLRKEG--FQPRSTDAGV------------------------ >M_musculus_ENSMUSP00000004949 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MSLLNCENSCGSSQSSSDCCAAM-AASCSAAVKDD--SVSGSA-- ST-GNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQ-TPCGHRFCKACIIKSI -----------RDAGHKCPVDN----------EILL-ENQLFPDNFAKREILSLTVKCPN -----------------KGCLQKMELRHLE--DH--QVHCEFALVNCP-------QCQRP FQKCQVNT----HIIEDCP---RRQVSCVNCAVSMAYEEK-E--IHDQ-SCPLANIICEY -CG---TILIREQMPNHYDLDCPTAPIPCT-FSVFGCHE-K---MQRNHLARHLQENTQL HMRLLA--QAVHNVNL-ALRP--------------CDAAS-------------------- -----------------------PSRG--C------------RPEDPNYE--ETIKQ--- ---------------LESRLVRQDHQ--------------------------------IR ELTAK--------------------------METQ-----S------------------- ------------------------------------------------------------ ------------MYVGELKRTIRTLEDKVAEMEAQQ---------------CNGIYIWKI G-NFGMHLKSQEEE-----RP--VVIHSPGFYTGRP-GYKL-------CMRLHLQ----- --------LPTAQRCANYISLFV---HTMQ-----------GEYDSHL-----P-WPFQG T---IRLTILDQSEAL--IR-QNHEEVMDAKPELLA-FQRP------------TIPRNPK GFGYVT-------------------FMHLEALRQG---T--FIKDDTLLVRCEVSTRFDM GGLRKEG--FQPRSTDAGV------------------------ >T_guttata_ENSTGUP00000010462 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MSLLHSDSSCGGRDAESGCCAAM-ASACSAAAKEE--SSSVGS-- AV-GTAPGSFGEETQGYDVEFDPPLESKYECPICLMALREAVQ-TPCGHRFCKGCIVKSI -----------RDAGHKCPVDN----------EILL-ENQLFPDNFAKREILSLMVKCPN -----------------KGCSMKMELRHLE--DH--QLQCDFSTVECL-------QCQGT FPKNHLKE----HMTQECP---RRQVCCPNCATSMAYEDK-E--LHDQ-TCPLANIYCEY -CN---TVLIREQMPNHYDNDCPTAPVPCF-YSAFGCPE-K---MQRNELARHMQEFTQV HMRMMA--QSFQNISVTAANP------VPFINGLPFEPAL-------------------- -----------------FSHVSHAAYN--C------------NPEVENFK--ETIQQ--- ---------------LEGRLVRQDHQ--------------------------------IR ELIAK--------------------------METQ-----N------------------- ------------------------------------------------------------ ------------THMAELKRTIRNLEGKITEMEAQQ---------------CNGIYIWKI E-NFSGLQRAQEEE-----RP--VVLHSPGFYTGKP-GYKL-------CLRLHIQ----- --------LPNAQRCANFISLFV---HTMQ-----------GEYDSHL-----P-WPFQG T---IRLSILDQSEGP--ER-QNHEEVMEAKPELLA-FQRP------------TIHRNPK GFGYVT-------------------FMHLETLKQR---T--FIKDDTLLVRCEVLTRLDL SSVRREG--FQPRSTDGAM------------------------ >B_taurus_ENSBTAP00000021630 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MSLLHCENSCGSSQSESDCCAAMAASSCGTAAKDD--SVSGTA-- ST-VTLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQ-TPCGHRFCKACIIKSI -----------RDAGHKCPVDN----------EILL-ENQLFPDNFAKREILSLMVKCPN -----------------EGCLHKMELRHLE--EH--QAHCEFALMSCP-------QCQRP FQKCHLNI----HILKECP---RRQVPCENCAVSMAFEDK-E--IHEQ-NCPLANVICEY -CN---TMLIREQMPNHYDLDCPTAPVPCT-FSAFGCHE-K---MQRNHLARHLQENTQS HMRMMA--QAVQTLSL-AVAP------VPQCTMPLYDSVP-------------------- --------------------PTRPSSG--R------------HSEVHNFQ--ETIQQ--- ---------------LEGRLVRQDHQ--------------------------------IR ELTAK--------------------------METQ-----S------------------- ------------------------------------------------------------ ------------MYVNELKRTIRTLEDKVAEIEAQQ---------------CNGIYIWKI G-NFGMHLKSQEEE-----KP--VVIHSPGFYTGKP-GYKL-------CMRLHLQ----- --------LPSAQRCANYISLFV---HTMQ-----------GEYDSHL-----P-WPFQG T---IRLTILDQSEAA--VR-QNHEEIMDAKPELLA-FQRP------------TIPRNPK GFGYVT-------------------FMHLEALRQR---T--FIKDDTLLVRCEVSTRFDM GSLRREG--FQPRSTDSGI------------------------ >C_familiaris_ENSCAFP00000010159 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MSLLNCENSCGSSQSESDCCPAM-ASSCSAAVKDD--SVSGTT-- ST-GNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQ-TPCGHRFCKACIIKSI -----------RDAGHKCPVDN----------EILL-ENQLFPDNFAKREILSLMVKCPN -----------------EGCLHKMELRHLE--DH--QLHCEFALMNCL-------QCQRT FQKCQLNI----HILKECP---RRQVSCMNCAALMAFEDK-E--IHDQ-NCPLANVICEY -CN---TMLIREQMPNHYDLDCPTAPIPCT-FSTFGCHV-K---MQRNHLARHLQENTQS HMRMLG--QAVQSLSL-ALAP------VPQRDVPPYDSSS-------------------- --------------------VSRVSST--C------------HPEVQNFQ--ETIQQ--- ---------------LEGRLVRQDHQ--------------------------------IR ELTAK--------------------------METQ-----S------------------- ------------------------------------------------------------ ------------MHVSELKRNIRTLEDKVAEIEAQQ---------------CNGIYIWKI G-NFGMHLKSQEEE-----KP--VVIHSPGFYTGKP-GYKL-------CMRLHLQ----- --------LPTAQRCANYISLFV---HTMQ-----------GEYDSHL-----P-WPFQG T---IRLAILDQSEAP--VR-QNHEEIMDAKPELLA-FQRP------------TIPRNPK GFGYVT-------------------FMHLEALRQR---T--FIKDDTLLVRCEVSTRFDM GSPRREG--FQPRSTDSGI------------------------ >G_gallus_ENSGALP00000012873 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MSLLHSDSSCGGRDLDSGCCTAM-ASACSGGAKED--SVSVGS-- GT-GNPPSSFTEETQGYDVEFDPPLESKYECPICLMALREAVQ-TPCGHRFCKGCIVKSI --------RRCRDAGHKCPVDN----------EILL-ENQLFPDNFAKREILSLTVKCPN -----------------KGCCLKMELRHLE--EH--QLHCDFTTVECP-------QCQGA FQKNHLKE----HMTQECP---RRQVCCPNCATSMAYEDK-E--LHDQ-TCPLANVFCEY -CN---TMLIRQQMPNHYDNDCPTAPVPCF-YSAFGCPE-K---MQRNELARHMQEFTQV HMRMMA--QSIQNISVTATNP------VPFINGLPFEPAL-------------------- -----------------FSHVSRAPYN--C------------NPEVENFK--ETIQQ--- ---------------LEGRLVRQDHQ--------------------------------IR ELIAK--------------------------METQ-----N------------------- ------------------------------------------------------------ ------------THMAELKRTIRDLEGKITEMEAQQ---------------CNGIYIWKI E-NFSGLQKAQEEE-----RP--VVMHSPGFYTGKP-GYKL-------CLRLHIQ----- --------LPSAQRCANFISLFV---HTMQ-----------GEYDSHL-----P-WPFQG T---IRLSILDQSEGP--ER-QNHEEVMEAKPELLA-FQRP------------TIHRNPK GFGYVT-------------------FMHLQTLKQR---T--FVKDDTLLVRCEVLTRLDL NSLRREG--FQARSTDGAA------------------------ >M_mulatta_ENSMMUP00000021907 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M YILKERIRASDNQVTMSLLNCENSCGSSQSESDCCVAM-ASSCSAATKDD--SVGGTA-- ST-GNLSSSFMEDIQGYDVEFDPPLESKYECPICLMALREAVQ-TPCGHRFCKACIIKSI -----------RDAGHKCPVDN----------EILL-ENQLFPDNFAKREILSLMVKCPN -----------------EGCLHKMELRHLE--DH--QAHCEFALVDCP-------QCQRP FQKFHINI----HILKDCP---RRQVSCDNCAALVAFEDK-E--IHDQ-NCPLANVICEY -CN---TILIREQMPNHYDLDCPTAPIPCT-FSTFGCHE-K---MQRNHLARHLQENTQS HMRMLA--QAVHSLSL-----------IP------------------------------- ------------------------DSG--Y------------VSEVRNFQ--ETIHQ--- ---------------LEGRLVRQDHQ--------------------------------IR ELTAK--------------------------METQ-----S------------------- ------------------------------------------------------------ ------------TYVSELKRTIRTLEDKVAEIEAQQ---------------CNGIYIWKI G-NFGMHLKCQEEE-----KP--VVIHSPGFYTGKP-GYKL-------CMRLHLQ----- --------LPTAQRCANYISLFV---HTMQ-----------GEYDSHL-----P-WPFQG T---IRLTILDQSEAP--VR-QNHEEIMDAKPDLLA-FQRP------------TIPRNPK GFGYVT-------------------FMHLEALRQR---T--FIKDDTLLVRCEVSTRFDM GSLRREG--FQPRSTDSGV------------------------ >A_carolinensis_ENSACAP00000005007 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MSLLHSNTSFETNSQESGCCAAM-ASACSAAAKEE--SINASVSN ETGGTLSNSFMEETQGYDVEFDPPLESKYECPICLMALREAVQ-TPCGHRFCKACIVKSI -----------RDAGHKCPIDN----------EILL-ETQLFPDNFAKREILSLTVKCPN -----------------KGCDQKMELRHLE--DH--QQHCGFASEKCP-------QCQGI FQKNRLQE----HIKLECP---RRQVSCPNCALLMPYEDK-E--VHDG-VCLLANVCCEY -CN---TVLIREQLPNHYDNDCPTAPVPCT-YSDFGCPE-K---MQRNELARHWQEFTQV HMRMMA--QTLRNVHVTNPAS------------GNFHAMP-------------------- -----------------------PSCE--C------------SPEVRNFK--ETIQQ--- ---------------LEGRLVRQDHQ--------------------------------IR ELIAK--------------------------METQ-----N------------------- ------------------------------------------------------------ ------------SQVGDLKGTIKNLEEKITELEAQQ---------------CNGIFIWKI E-HFSVYLKALEEE-----RP--VVIHSPGFYTGKP-GYKL-------CMRLHIQ----- --------LPNVQRCANYISLFV---HIMQ-----------GEYDNYL-----P-WPFQG T---IRLSVLDQSEGS--PR-QNHEEVMDTKPELLA-FQRP------------KTRRNPK GFGYVT-------------------FMQLQTLRQR---T--YIKEDTVLVRCEVLTRLDV MSPRREG--FQPRSTDGTV------------------------ >H_sapiens_ENSP00000316840 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MSLLNCENSCGSSQSESDCCVAM-ASSCSAVTKDD--SVGGTA-- ST-GNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQ-TPCGHRFCKACIIKSI -----------RDAGHKCPVDN----------EILL-ENQLFPDNFAKREILSLMVKCPN -----------------EGCLHKMELRHLE--DH--QAHCEFALMDCP-------QCQRP FQKFHINI----HILKDCP---RRQVSCDNCAASMAFEDK-E--IHDQ-NCPLANVICEY -CN---TILIREQMPNHYDLDCPTAPIPCT-FSTFGCHE-K---MQRNHLARHLQENTQS HMRMLA--QAVHSLSV-----------IP------------------------------- ------------------------DSG--Y------------ISEVRNFQ--ETIHQ--- ---------------LEGRLVRQDHQ--------------------------------IR ELTAK--------------------------METQ-----S------------------- ------------------------------------------------------------ ------------MYVSELKRTIRTLEDKVAEIEAQQ---------------CNGIYIWKI G-NFGMHLKCQEEE-----KP--VVIHSPGFYTGKP-GYKL-------CMRLHLQ----- --------LPTAQRCANYISLFV---HTMQ-----------GEYDSHL-----P-WPFQG T---IRLTILDQSEAP--VR-QNHEEIMDAKPELLA-FQRP------------TIPRNPK GFGYVT-------------------FMHLEALRQR---T--FIKDDTLLVRCEVSTRFDM GSLRREG--FQPRSTDAGV------------------------ >P_pygmaeus_ENSPPYP00000003845 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MSLLNCENSCGSSQSESDCCVAM-ASSCSAATKDD--SVGGTA-- ST-GNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQ-TPCGHRFCKACIIKSI -----------RDAGHKCPVDN----------EILL-ENQLFPDNFAKREILSLMVKCPN -----------------EGCLHKMELRHLE--DH--QAHCEFALMDCP-------QCQRP FQKFHINI----HILKDCP---RRQVSCDNCAASMAFEDK-E--IHDQ-NCPLANVICEY -CN---TILIREQMPNHYDLDCPTAPIPCT-FSTFGCHE-K---MQRNHLARHLQENTQS HMRMLA--QAVHSLSL-----------IP------------------------------- ------------------------DSG--Y------------ISEVRNFQ--ETIHQ--- ---------------LEGRLVRQDHQ--------------------------------IR ELTAK--------------------------METQ-----S------------------- ------------------------------------------------------------ ------------MYVSELKRTIRTLEDKVAEIEAQQ---------------CNGIYIWKI G-NFGMHLKCQEEE-----KP--VVIHSPGFYTGKP-GYKL-------CMRLHLQ----- --------LPTAQRCANYISLFV---HTMQ-----------GEYDSHL-----P-WPFQG T---IRLTILDQSEAP--VR-QNHEEIMDAKPELLA-FQRP------------TIPRNPK GFGYVT-------------------FMHLEALRQR---T--FIKDDTLLVRCEVSTRFDM GSLRREG--FQPRSTDAGV------------------------ >P_troglodytes_ENSPTRP00000006096 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MSLLNCENSCGSSQSESDCCVAM-ASSCSAATKDD--SVGGTA-- ST-GNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQ-TPCGHRFCKACIIKSI -----------RDAGHKCPVDN----------EILL-ENQLFPDNFAKREILSLMVKCPN -----------------EGCLHKMELRHLE--DH--QAHCEFALMDCP-------QCQRP FQKFHINI----HILKDCP---RRQVSCDNCAASMAFEDK-E--IHDQ-NCPLANVICEY -CN---TILIREQMPNHYDLDCPTAPIPCT-FSTFGCHE-K---MQRNHLARHLQENTQS HMRMLA--QAVHSLSL-----------IP------------------------------- ------------------------DSG--Y------------ISEVRNFQ--ETIHQ--- ---------------LEGRLVRQDHQ--------------------------------IR ELTAK--------------------------METQ-----S------------------- ------------------------------------------------------------ ------------MYVSELKRTIRTLEDKVAEIEAQQ---------------CNGIYIWKI G-NFGMHLKCQEEE-----KP--VVIHSPGFYTGKP-GYKL-------CMRLHLQ----- --------LPTAQRCANYISLFV---HTMQ-----------GEYDSHL-----P-WPFQG T---IRLTILDQSEAP--VR-QNHEEIMDAKPELLA-FQRP------------TIPRNPK GFGYVT-------------------FMHLEALRQR---T--FIKDDTLLVRCEVSTRFDM GSLRREG--FQPRSTDAGV------------------------ >O_cuniculus_ENSOCUP00000010330 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MSLLNCENSCGSGQSESDCCAAM-ASSCSAAAKDD--SVSGTA-- ST-GNLSGSFVEDIQGYDVEFDPPLESKYECPICLMALREAVQ-TPCGHRFCKACIIKSI -----------RDAGHKCPVDN----------EILL-ENQLFPDNFAKREILSLTVKCPN -----------------EGCLHKMELRHLEXXXX--XXXXXXXXXXXX-------XXXXX XXXXXXXX----XXXXXXX---XXXXXXXXXXXXXXXXXX-X--IHDQ-NCPLANVICEY -CN---TMLIREQMPNHYDLDCPTAPIPCT-FSTFGCHE-K---MQRNHLARHLQEKTQL HMRMLA--QAVHSLNL-ALTP------IP------------------------------- ------------------------DSG---------------YPEGHNFQ--ETIQQ--- ---------------LEGRLVRQDHQ--------------------------------IR ELTAK--------------------------METQ-----S------------------- ------------------------------------------------------------ ------------MYVSELKRTIRTLEDKVAEIEAQQ---------------CNGIYIWKI G-NFGMHLKSQEEE-----KP--VVIHSPGFYTGKP-GYKL-------CMRLHLQ----- --------LPTAQRCANYISLFV---HTMQ-----------GEYDSHL-----P-WPFQG T---IRLTILDQSEAP--IR-QNHEEIMDAKPELLA-FQRP------------TIPRNPK GFGYVT-------------------FMHLEALRQR---T--FIKDDTLLVRCEVSTRFDM GSLRREG--FQPRSTDAGV------------------------ >G_aculeatus_ENSGACP00000022648 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MASAE-SGKGSLQEDSYEGPVGGELSGCALAM-MEKERESLLSP--SESPGTFI SG-SSASLQAPAPLQGYDVEFDPPLESKYECPICLMALRNAIQ-TPCGHRFCKNCIEKSI -----------RDTGQRCPVDN----------ERLL-EDQLFPDNFAKREILSLTVRCPN -----------------SDCADKMELRHLE--NH--LGRCQFATVPCS-------QCQQA VRKSRLEE----HQTAECQ---KRPVSCPDCVASFFYEER-K--LHQQ-RCPFAIVKCLF -CD---LELIRDQIESHCDTDCPKAPIACN-FSAFGCKE-S---MQRHNLAQHMQEFTQM HMRYMA--EFLRGLSLNGTTPKSLWAPAPSAYPEDQGATA-------------------- -----ALAAVCSGP--RGAPSSMSSNS--CA-----------PSQPAEGM--QRLRE--- ---------------MDGRLVKQDHQ--------------------------------LR ELIIL--------------------------KETQ-----A------------------- ------------------------------------------------------------ ------------GQLAELRRRVSLLEDTVKELESQQ---------------CHGIFIWRL R-GFSAHLRNQEAG-----QP--VVEHSPGFYTGRP-GYKL-------CLRLHLQ----- --------TPNAPRCSNFISLFV---HTMQ-----------GAFDGQL-----S-WPFQG T---IRLAILDQGP----EA-QHHVEVMETKPDLQA-FQKP------------LIQRNPK GFGYVT-------------------FLHLHQLTQR---A--FVKDDTLLIRCEVTPRFD- NVLHRDGPTVQPRGPEASVSRD--------------------- >X_tropicalis_ENSXETP00000016445 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MSILNCRPSFDGVDTDDACCGAM-ASACCVNTKEDGESPSAGS-- PS-GTPQSLVLEDVQGYDVEFDPPLESKYECPICLMALREAVQ-TPCGHRFCKACILKSI -----------RDAGHKCPVDN----------ESLM-ENQLFPDNFAKREILSLRVKCPS -----------------QGCTETMELRHLE--RH--LVRCDFAGVECS-------QCQSS FPKYSLQK----HMFEECP---RRQIFCENCALAMALEDK-L--NHDQ-TCPLAYVTCEY -CQ---TNLIREQMPAHYSMDCTMAPIPCM-YYEFGCTE-K---MQRNDLARHLQEFTQA HMRMMA--QTLRSFSS-SVTPTSHMPDISFCDPSQFEPAP-------------------- -------------PSVATVHSSHTPSQNDC------------TQETRNLR--ETIEQ--- ---------------LEGRLVRQDHQ--------------------------------IR ELIAK--------------------------METQ-----C------------------- ------------------------------------------------------------ ------------TYVNELKHTIRSLDNRLGEMESQQ---------------CSGIFIWRI N-NFNSLLKNQEEE-----RP--VVIHSQGFYTGKP-GYKL-------CLRLHLQ----- --------LPSAQRCANYISLFV---HTMQ-----------GEYDSLL-----P-WPLQG T---IRLSILDQSEGV--AM-QDQEEVMDTKPELLA-FQRP------------TVARNPK GFGYVT-------------------FMHLQALKQR---Q--YVKNDTLLVRCSVTTHLDL ISPRREG--FQPRSGDGAL------------------------ >D_rerio_ENSDARP00000036715 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------MACNDVDKSSFDDVCCDSGHSSCAAAM--EKERESFLSP--TENPST-- ---ISVSSSMPPDQQGYDVEFDPPLESKYECPICLMGLRSAVQ-TPCGHRFCDSCIRKSI -----------RDTGQKCPVDN----------EVLL-EEQLFPDNFAKREILSLTVKCSN -----------------FGCSEKMELRQLE--KH--LSQCRFATAPCP-------QCQES VPISHLDE----HKSQHCL---QRIMTCPDCAGSFVYAVK-Q--NHEQ-FCPFANTVCEY -CE---MELIRDQLALHCDTDCLKAPVACT-FSTFGCRE-K---MTRNELAQHMQEFTQM HMRYMA--EFLRSQTLNNCTMPSAAAHLSSDDRG-------------------------- -------------------ASARSPDSCQC------------KQELLNLR--ETVLE--- ---------------LEGRLVRQDQQ--------------------------------IR ELCIH--------------------------NDTQ-----K------------------- ------------------------------------------------------------ ------------NQVTELRRKLVSLEESTRELEAQQ---------------YQGIYVWRV E-NFSHHLRNQEAG-----QP--IVLHSPPFYTGRP-GYKL-------CLRLHLQ----- --------TPSAPRCSNFISLFV---HTMQ-----------GEFDSQL-----S-WPLQG T---IRLAVLDQVEG------QHHIEVMETKPDLQA-FQRP------------TVMRNPK GFGYVT-------------------FLHLQALRQR---G--FVKEDVLLVRCEVTPRFD- ASLRREG--VQPRGPEPSI------------------------ >T_nigroviridis_ENSTNIP00000012472 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MACFDSSSKGSLEEDSCDGAIGGELSGCALVM-MEKEQESLLSP--SESPGTYM SG-ASSSFHDGTHQQGYDVEFDPPLESKYECPICLMALRNAIQ-TPCGHRFCKNCIEKSI -----------RDAGQRCPVDN----------EMLS-KEQLFPDNFAKREILSLIVRCSN -----------------PGCTSKMELRHLE--NH--LASCEFATVPCP-------HCQQS VKKTLLEE----HTSVQCR---RRPVSCPDCVEIFVYEEK-E--RHEQ-QCPFASVMCPH -CD---MDLTRDQMESHCDTDCPKAPIACN-FSLFGCKE-R---MQRHDLARHMQDFTQM HMHYMA--DFLRSLNLNGTIPKDQGA----------AASA-------------------- ----------------SSCSKGALSSN--CT-----------PCQPTEEM--QRLRE--- ---------------MDRRLVKQDHQ--------------------------------LR ELIIL--------------------------KENQ-----T------------------- ------------------------------------------------------------ ------------GQIAELRKRVSVLEESMRELESQH---------------CTGIYIWRL K-DFSVLLRNQEAG-----LP--VVEHSPGFYTGRP-GYKL-------CLRLHLQ----- --------SPVAQRCSNFISLFV---HTMQ-----------GAYDGLL-----T-WPFQG T---IRLAILDQGP----EG-QHHIEVMETKPDLQA-FQRP------------TIIRNPK GFGYVT-------------------FLHLHHLKER---A--YVKDDALLIRCEVTPRFD- NMLHRDGVTVQPRGSEASI------------------------ >T_rubripes_ENSTRUP00000041697 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MACFD-SSKESL-EDSFDGAAGGKLSGCALAM-SEKERESLLNP--SESPSTYM SG-ASSSFQDATHQQGYDVEFDPPLESKYECPICLMALRNAIQ-TPCGHRFCKICIEKSI -----------RDAGQRCPVDN----------EMLS-KEQLFPDNFAKREILSLTVRCSN -----------------PGCTGKMELRHLE--DH--LAHCQFATVPCP-------HCQQS VRKTILEE----HMTAECR---RRPVSCPDCIETFVYEER-E--RHEQ-QCPFASVMCPY -CD---MDLVRDQMESHCDTDCPIAPIACT-FSLFGCKE-R---MQRHDLARHMQDFTQM HMHYMA--DFLRGLNLNGTTPKPLGAIGHSISFEDHGASA-------------------- ----------------SSCDKGVSSSN--CA-----------PCQPNEET--QRLRE--- ---------------MDRRLVKQDHQ--------------------------------LR ELIIL--------------------------KETQ-----A------------------- ------------------------------------------------------------ ------------GQLAELGRRVSMLEETVRELESQH---------------CTGIFIWRL K-DFSVLLRNQEAG-----LP--VVEHSPAFYTGRP-GYKL-------CLRLHLQ----- --------SPNAQRCSNFISLFV---HTMQ-----------GAFDGRL-----T-WPFQG T---IRLAILDQGP----EG-QHHVEVMETKPDLQA-FQKP------------TIIRNPK GFGYVT-------------------FLHLQQLNQR---A--YVKDDILLIRCEVTPRFD- NMFHRDGITVQPRGPEASM------------------------ >E_caballus_ENSECAP00000018618 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MSLLNCENSCGSSQTESDCCAAM-ASSCSAAAKDD--SVSGTA-- ST-GNLSSSFMEDIQGYDVEFDPPLESKYECPICLMALREAVQ-TPCGHRFCKACIIKSI -----------RDAGHKCPPD-----------EILY-HP---ASSLTRRESL-LCPMCPH -----------------CMCYPPSKLYHRS--DH--QAHCEFALMNCP-------QCQHP FQKCQLNI----HMLKECP---RRQVSCVNCAVSMAFEDK-EASIHDQ-NCPLANVICEY -CN---TMLIREQMPNHYDLDCPTAPIPCT-FNTFGCHE-K---MQRNHLARHLQENTQS HMRMLA--QAVQSLSL-ALAP------VPQRDMLPYDSAP-------------------- --------------------LSRVSSG--C------------YPEVRNFQ--ETIQQ--- ---------------LEGRLVRQDHQ--------------------------------IR ELTAK--------------------------METQ-----S------------------- ------------------------------------------------------------ ------------IYVSELKRTIRTLEDKVAEIEAQQ---------------CNGIYIWKI G-NFGMHLKSQEEE-----KP--VVIHSPGFYTGKP-GYKL-------CMRLHLQ----- --------LPTAQRCANYISLFV---HTMQ-----------GEYDSHL-----P-WPFQG T---IRLTILDQSEAP--IR-QNHEEIMDAKPELLA-FQRP------------TIPRNPK GFGYVT-------------------FMHLEALRQR---T--FIKDDTLLVRCEVSTRFDM GSLRREG--FQPRSTDTGV------------------------ >O_latipes_ENSORLP00000001290 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------ASGGGLSECASAM-LEKERESLPSP--SDNPTA-- SM-GSSSLQAAAPLQGYDVEFDPPLESKYECPICLMALRNAIQ-TRCGHRFCKSCIEKSI -----------RDTGQRCPVDN----------EMLS-EDQLFPDNFAKREILSLTVRCPN -----------------SDCGEKMELRHLE--KH--LAQCQFATVPCS-------QCQQP VRKSYLEE----HATVECP---RRPMSCPDCVAVFVYEER-E--MHEQ-QCPFASVMCQY -CE---MDLIRDQMESHCDTDCPKAPIACT-FSIFGCKE-R---MQRHNLAQHMQEFTQM HMRYMD--IRMTTLTKKTKTTKNALIVIYFFFPKICVFLV-------------------- -----QLQHRLRGSSTRSAASQLILQS--CEFTLYSHSKRLVKNCFYHLR---NVAK--- ---------------LKPMLTRSDLELIIDSVKCFKAQGFPSLVKCQNILKTPKTQFSLE WVLRH--------------------------KDRKSNHKLA------------------- ------------------------------------------------------------ ------------GQLAELRRRVSVLEETVKELEAQQ---------------YHGIFIWRL K-AFSTHLRSQEAG-----IP--VVEHSPGFYTGRP-GYKL-------CLRLHLQ----- --------TPTAPRCSNFISLFV---HTMQ-----------GVFDSQL-----T-WPFQG T---IRLAILDQGP----EG-QHHMEVMETKPDLQA-FQKP------------INQRNPK GFGYVT-------------------FMHRSLLSQR---A--YVKDDTLLIRCEV------ ------------------------------------------- >M_mulatta_ENSMMUP00000021905 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------LNCENGCGSSQSESDYCVAM-ASSCSAATKDD--SVGGTA-- SM-GNLSSSFMEEIQGYDVEFDPPLESRYECPICLTALREAVQ-TPCGHRFRKGCIIKSI -----------RDAGHKCPVDD----------EILL-ENKLFPDSFAKREILSLMVNCPN -----------------EGCLHKMELRHLG--DH--QAHCEFALMDCP-------QCQHP FQKFHINI----HILKDCP---RRQVSCDNCAASMAFIKR-S--V-DQ-NCPLANVICEY -CN---TILIREQ-ASYYDVDCPTAPIPCT-FRTFDCHE-K---MQRNHLSHHLQE-TPC HTRMLT--QAVHSLSL-----------IP------------------------------- ------------------------DSG--Y------------ISEARNFQ--ETSHQ--- ---------------LEDRLVGQDNQ--------------------------------IQ ELTDE--------------------------IETQ-----S------------------- ------------------------------------------------------------ ------------IYVSE----IRTLEDKVADIEAQQ---------------CNGIYIWKI G-S---HLKCQEEE-----KP--VVIHSPGFYTGKP-GYKL-------CMRLHLQ----- --------LLTAQRCANYISLFV---HTMQ-----------GEYDSHL-----P-WPF-G T---ICLTILDQSQAP--VR-QNHEEIMDAKPELLA-FQQP------------TYP-NPK GFGYVT-------------------FIHLEALRQR---T--FIKYDTLLVRCEVSTCFDM GSLRREG--FQPQSTDAGI------------------------ >G_gorilla_ENSGGOP00000005734 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MSLLNCENSCGSSQSESDCCVAM-ASSCSAATKDD--SVGGTA-- ST-GNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQ-TPCGHRFCKACIIKSI -----------RDAGHKCPVDN----------EILL-ENQLFPDNFAKREILSLMVKCPN -----------------EGCLHKMELRHLE--XX--XXXXXXXXXXXX-------XXXXX XXXXXXXX----XXXXXXX---XXXXXXXXXXXXXXXXXX-X--XXXX-XXXXXXXXXXX -XX---XXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXX-X---MXRNHLARHLQENTXS XMRMLA--QAVHSLSL-----------IX------------------------------- ------------------------XSG--Y------------ISEVRNFQ--EXIHQ--- ---------------LEGRLVRQXHQ--------------------------------IR ELTXK--------------------------METQ-----S------------------- ------------------------------------------------------------ ------------MYVSELKRTIRTLEDKVAEXEAQQ---------------CNGIYIWKI G-NFGMHLKCQEEE-----KP--VVIHSPGFYTGKP-GYKL-------CMRLHLQ----- --------LPTAQRCANYISLFV---HTMQ-----------GEYDSHL-----P-WPFQG T---IRLTILDQSEAP--VR-QNHEEIMDAKPELLA-FQRP------------TIPRNPK GFGYVT-------------------FMHLEALRQR---T--FIKDDTLLVRCEVSTRFDM GSLRREG--FQPRSTDAGV------------------------ >O_latipes_ENSORLP00000005579 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MPGFDYKFLEKPKRRFQCPLCSKAMREPVQVSTCGHRFCDTCLQEFL -----------SEGVFKCPEDQ----------LPLD-YAKIYPDPELEQQILSLPIRCIH ---------------SEEGCRWTGQMKQLQ--GH--FSTCAFNVIPCPN------RCSVK LTRRDLPD----HLQHDCP---KRKVKCEFCGSEFTGEAF-E--NHQG-VCPQESVYCEN KCG---ARMMRRLLSQHGMAECPKRTQPCK-Y----CGK-E---FVFDTIQNHQFHCPRF PVQCPNQCGTPNIAREDLANHVKDNCGSALVLCPFKDAGC-------------------- ------------------------------------------KHRCPKLAIGRHLED--- ------------------------------------------------------------ TTKSH--------------------------LTMM-----C------------------- ------------------------------------------------------------ ------------NLVSRQRQEILELRREMEELSVS----------------HDGVLIWKL N-DYSRKLQEAKLR-----SN--HEFFSPPFYTHRY-GYKL-------QVSAFLN----- --------GNGSGE-GSHLSVYI---RVLP-----------GEYDNLL-----E-WPFSY K---VTFSILDQSDPSLSKP-QHITETFNPDPNWKN-FQKP-----CSTRNS-LDESTLG F-GYPK-------------------FISHEEIKKR---N--YIRDNCIFIKASIEIPQKI MG----------------------------------------- >M_domestica_ENSMODP00000024090 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MPGFDYKFLEKPKRRLLCPLCAKAMREPVQVSTCGHRFCDTCLQEFL -----------SEGVFKCPEDQ----------LPLD-YAKIYPDPELEAQVLSLPIRCIH ---------------SEEGCRWTGALRQLQ--VH--LSSCGYNVVACPN------RCNGK LSRRDLPS----HLQHECP---KRRLKCDFCGIDFTGEAF-E--SHEG-VCPQESVYCEN KCG---ARMMRRLLGQHMMAECPKRTQPCA-Y----CTK-E---FVYDTIQNHQHQCPRY PIPCPNQCGMGSIPREDLNSHLKENCSTVPVLCPFKDAGC-------------------- ------------------------------------------KHRCPKLAMGRHMEE--- ------------------------------------------------------------ SVKPH--------------------------LAMM-----C------------------- ------------------------------------------------------------ ------------ALVSRQRQELQELRRDVEELSVG----------------CDGVLIWKI G-GYGRRLQEAKAR-----AN--HECFSPAFYTHKY-GYKL-------QVSAFLN----- --------GNGSGE-GTHLSLYI---RVLP-----------GAFDNLL-----E-WPFAR R---VTFSLLDQSDPAVAKP-QHVTETFHPDPHWKN-FQKP-----GTWRGS-MDESALG F-GYPK-------------------FISHQDIRKR---N--YVRDDAVFIRASVELPKKI LS----------------------------------------- >T_rubripes_ENSTRUP00000012878 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MPGFDYKFLEKPKRRFQCPLCSKAMREPVQVSTCGHRFCDTCLQEFL -----------SEGVFKCPEDQ----------LPLD-YAKIYPDPELEQQILALAIRCIH ---------------SEEGCRWTGQMKQLQ--GH--FSTCAFNVIPCPN------RCSVK LTRRDLPD----HLQHDCP---KRKVKCEFCGSEFTGEAY-E--NHQG-VCPQESVYCEN KCG---ARMMRRLLSQHGMAECPKRTQPCK-Y----CSK-E---FVFDTIQNHQYHCPRF PVQCPNQCGTPNIAREDLANHVKDNCGSALVLCPFKDAGC-------------------- ------------------------------------------KHRCPKLAIGRHLED--- ------------------------------------------------------------ TTKSH--------------------------LTMM-----C------------------- ------------------------------------------------------------ ------------NLVGRQRQEILELRREMEELSVG----------------HDGILIWKL N-DYSRKLQEAKIR-----SN--HEFFSPPFYTHRY-GYKL-------QVSAFLN----- --------GNGSGE-GSHLSVYI---RVLP-----------GEYDNLL-----E-WPFSY K---VTFSLLDQSDPSLSKP-QHITETFNPDPNWKN-FQKP-----SSTRNS-LDESTLG F-GYPK-------------------FISHEEIKKR---N--YVRDNCIFIKASIEIPQKI MA----------------------------------------- >G_aculeatus_ENSGACP00000014759 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MPGFDYKFLEKPKRRFQCPLCSKAMREPVQVSTCGHRFCDTCLQEFL -----------SEGVFKCPEDQ----------LPLD-YAKIYPDPELEQQILALPIRCIH ---------------SEEGCRWTGQMKQLQ--GH--FSTCAFNVIPCPN------RCSVK LTRRDLPD----HLQHDCP---KRKVKCEFCGSEFTGEAY-E--NHQG-VCPQESVYCEN KCG---ARMMRRLLSQHGLAECPKRTQPCK-Y----CGK-E---FVFDTIQNHQYHCPRF PVQCPNQCGTPNIAREDLANHVKDNCGSALVLCPFKDAGC-------------------- ------------------------------------------KHRCPKLAIGRHLED--- ------------------------------------------------------------ TTKSH--------------------------LTMM-----C------------------- ------------------------------------------------------------ ------------NLVGRQRQEILELRREMEELSVS----------------HDGVLIWKL S-DYSRKLQEAKLR-----SN--HEFFSPPFYTHRY-GYKL-------QVSAFLN----- --------GNGSGE-GSHLSVYI---RVLP-----------GEYDSLL-----E-WPFSY K---VTFSILDQSDPSLSKP-QHITETFNPDPNWKN-FQKP-----SSSRNS-LDESTLG F-GYPK-------------------FISHDEIKKR---N--YIRDNCVFIKASIEIPQKI MT----------------------------------------- >D_rerio_ENSDARP00000013849 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MPGFDYKFLEKPKRRFQCPLCSKAMREPVQVSTCGHRFCDTCLQEFL -----------SEGVFKCPEDQ----------LPLD-YAKIYPDPELEQQILALPIRCIH ---------------SEEGCRWTGQMKQLQ--SH--FSTCAFNVIPCPN------RCSVK LTRRDLPE----HLQHDCP---KRKVKCEFCGSEFTGEAY-E--NHQG-ICPQESVYCEN KCG---ARMMRRLLSQHTMTECPKRTQPCK-Y----CGK-E---FVYDTIQNHQYHCPRF PVQCPNQCGTPNIAREDLANHVKESCGSALVLCPFKEAGC-------------------- ------------------------------------------KHRCPKMAIGRHLEE--- ------------------------------------------------------------ STKSH--------------------------LTMM-----C------------------- ------------------------------------------------------------ ------------SLVGRQRQEILELRREMEELSVS----------------HDGVLIWKL T-DYSRKLQEAKLR-----NN--HEFFSPPFYTHRY-GYKL-------QVSAFLN----- --------GNGSGE-GSHLSIYI---RVLP-----------GEYDNLL-----E-WPFSY K---VTFSILDQSDPSLSKP-QHITETFNPDPNWKN-FQKP-----CSSRNS-LDESTLG F-GYPK-------------------FISHEEIKKR---N--YIRDNSIFLKASIEIPQKI MA----------------------------------------- >O_anatinus_ENSOANP00000013484 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------SMGSEELTIGSRAF SHQNSSSCISLDFEPDIQYQFVEQLEERYKCTFCHSVLHNPHQ-TSCGHRFCQHCILSLR ----------ELNNFPTCPIDK----------KIIQ-LQEVFKDNCCKREVLNLQVFCKN ----------------APGCNSKMILGRYQ--DH--LQQCLFQPVQCSNE-----SCQEK VLRKDMKD----HLGCHCK---FREEKCQYCQKYVVAIDL-Q--NHEENFCPDYPVSCPF SCC---QIIPRTEVDEHI-SVCPEAEQDCP-YKQYGCLI-K---DKRRNLREHENAALRE HMLLVL--DKNSRLEEKISDLHRSL-EVKELKIQQLAEMV-KKFEKEFRQVMQLFSKNGN LLANTQI------------LANHIDKSTWL------------ETQVRQLL--HMANQQQS KFD------------LKSLMETIDTV-----------KQKIA-LLETY-------DQRLV VLKDQ--------------------------TRQH-----D------------------- ------------------------------------------------------------ ------------AHINAHKAQLNKNEERFKLLEGTC---------------YNGKLIWKV T-DYKMKKREAMEG-----RS--VSIFSQPFYTSRC-GYRL-------CARAYLN----- --------GDGSGK-GTHLSLYF---VVMK-----------GEFDSLL-----Q-WPFKQ K---VTMMLLDQSG----KK-NHIVEIFKADPNSSS-FKRP------------EGEMNIA S-GCPC-------------------FVDHSKLENVKN-T--FIKEDTLFMKVVVDL---- ----------------TDL---------------------EEL >B_taurus_ENSBTAP00000050075 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFL -----------SEGVFKCPEDQ----------LPLD-YAKIYPDPELEVQVLGLSIRCIH ---------------SEEGCRWNGPLRHLQ--GH--LNTCSFNVVPCPN------RCPAK LSRRDLPA----HLQHDCP---KRRLKCEFCGCDFSGEAF-E--SHEG-VCPQESVYCEN KCG---ARMMRRLLAQHATSECPKRTQPCT-Y----CTK-E---FVFDTIQSHQYQCPRL PVPCPNQCGVGTVAREDLPGHLKDSCSTALVLCPFKDSGC-------------------- ------------------------------------------KHRCPKLAMARHVEE--- ------------------------------------------------------------ SVKPH--------------------------LAMM-----C------------------- ------------------------------------------------------------ ------------ALVSRQRQELQELRRELEELSVG----------------SDGVLIWKI G-SYGRRLQEAKAK-----PN--LECFSPAFYTHKY-GYKL-------QVSAFLN----- --------GNGSGE-GTHLSLYI---RVLP-----------GAFDNLL-----E-WPFAR R---VTFSLLDQSDPGLAKP-QHVTETFHPDPNWKN-FQKP-----GTWRGS-LDESSLG F-GYPK-------------------FISHQDIRKR---N--YVRDDAVFIRASVELPRKI LS----------------------------------------- >H_sapiens_ENSP00000262395 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFL -----------SEGVFKCPEDQ----------LPLD-YAKIYPDPELEVQVLGLPIRCIH ---------------SEEGCRWSGPLRHLQ--GH--LNTCSFNVIPCPN------RCPMK LSRRDLPA----HLQHDCP---KRRLKCEFCGCDFSGEAY-E--SHEG-MCPQESVYCEN KCG---ARMMRRLLAQHATSECPKRTQPCT-Y----CTK-E---FVFDTIQSHQYQCPRL PVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGC-------------------- ------------------------------------------KHRCPKLAMARHVEE--- ------------------------------------------------------------ SVKPH--------------------------LAMM-----C------------------- ------------------------------------------------------------ ------------ALVSRQRQELQELRRELEELSVG----------------SDGVLIWKI G-SYGRRLQEAKAK-----PN--LECFSPAFYTHKY-GYKL-------QVSAFLN----- --------GNGSGE-GTHLSLYI---RVLP-----------GAFDNLL-----E-WPFAR R---VTFSLLDQSDPGLAKP-QHVTETFHPDPNWKN-FQKP-----GTWRGS-LDESSLG F-GYPK-------------------FISHQDIRKR---N--YVRDDAVFIRAAVELPRKI LS----------------------------------------- >D_rerio_ENSDARP00000014326 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------LEQQFICPSCGGIVLNPHQ-TGCGHIFCAQCVKAYT ----------ENGGSSKCPLDS----------IPIK-PEEIFQDNCCKRELLNLEVFCTN ----------------APECTQRFSLCNLQ--DH--LKACPHERVRCSHS-----DCSDI VLRKNLLE----HQRNACS---YRLETCHYCRQNFPVSQMMQ--GHQKSSCPDVEVPCSN NCT---QMIKRHQLQAHA-DECLEVETDCV-YKNYGCTV-R---DKRGKVQVHENTEFSA HVRLVL--EKLCEQTLCSLTMQSRVSTFSCDRRS-------------------------- -------------------VEEQRVRICSV------------QRELRDLR--VLGSE--- ---------------LKEELPRLQAS--------------------------------LD SLRQQ-----------------------------------V------------------- ------------------------------------------------------------ ------------AVTESLREHLVALKQHSTFLESSS---------------YDGKLIWKV R-DYWHRKESG------------AALSSSPFYTSRS-GYKL-------SVRAYLG----- --------GDGSGR-GSHMSLYI---TIMR-----------GDFDSFL-----P-WPFRQ N---ITLTLLDQSG----TR-NHMSHTFIPDVNSDS-FHRP------------TSDANVA T-GFTR-------------------FISHCDLENPRNAV--FVRDETLFIKVKV------ ------------------------------------------- >M_musculus_ENSMUSP00000017530 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFL -----------SEGVFKCPEDQ----------LPLD-YAKIYPDPELEVQVLGLAIRCIH ---------------SEEGCRWSGPLRHLQ--GH--LNTCSFNVVPCPN------RCPAK LSRRDLPA----HLQHDCP---KRRLKCEFCGCDFSGEAY-E--SHEG-VCPQESVYCEN KCG---ARMMRRLLAQHATSECPKRTQPCA-Y----CTK-E---FVYDTIQSHQYQCPRL PVPCPNQCGVGTVAREDLPTHLKDSCSTAFVLCPFKESGC-------------------- ------------------------------------------KHRCPKLAMGRHVEE--- ------------------------------------------------------------ SVKPH--------------------------LAMM-----C------------------- ------------------------------------------------------------ ------------ALVSRQRQELQELRRELEELSIG----------------SDGVLIWKI G-SYGRRLQEAKAK-----PN--LECFSPAFYTHKY-GYKL-------QVSAFLN----- --------GNGSGE-GTHLSIYI---RVLP-----------GAFDNLL-----E-WPFAR R---VTFSLLDQSDPGLAKP-QHVTETFHPDPNWKN-FQKP-----GTWRGS-LDESSLG F-GYPK-------------------FISHQDIRKR---N--YVRDDAVFIRASVELPRKI LS----------------------------------------- >R_norvegicus_ENSRNOP00000018468 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFL -----------SEGVFKCPEDQ----------LPLD-YAKIYPDPELEVQVLGLAIRCIH ---------------SEEGCRWSGPLRHLQ--GH--LNTCSFNVVPCPN------RCPAK LSRRDLPA----HLQHDCP---KRRLKCEFCGCDFSGEAY-E--SHEG-VCPQESVYCEN KCG---ARMMRRLLAQHATSECPKRTQPCA-Y----CTK-E---FVYDTIQSHQYQCPRL PVPCPNQCGVGTVAREDLPTHLKDSCSTAFVLCPFKESGC-------------------- ------------------------------------------KHRCPKLAMGRHVEE--- ------------------------------------------------------------ SVKPH--------------------------LAMM-----C------------------- ------------------------------------------------------------ ------------ALVSRQRQELQELRRELEELSVG----------------SDGVLIWKI G-SYGRRLQEAKAK-----PN--LECFSPAFYTHKY-GYKL-------QVSAFLN----- --------GNGSGE-GTHLSIYI---RVLP-----------GAFDNLL-----E-WPFAR R---VTFSLLDQSDPGLAKP-QHVTETFHPDPNWKN-FQKP-----GTWRGS-LDESSLG F-GYPK-------------------FISHQDIRKR---N--YVRDDAVFIRASVELPRKI LS----------------------------------------- >B_taurus_ENSBTAP00000015940 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MAYFEEQGGVPCGF TRQNSGNSISLDFEPDAEYQFVERLEERYKCAFCHSVLHNPHQ-TGCGHRFCHQCILALR ----------ELDTVPLCPVDK----------EVIK-SQEVFKDNCCKREVLNLYVFCKN ----------------APRCNAKIILGRYQ--DH--LQHCLFQPVQCSNE-----NCREP VLRKDLKE----HLSAYCQ---FREEKCLYCKKDVVVINL-Q--NHEENLCPDYPVSCPN KCL---QTIPRTEVDEHL-AVCPEAEQDCA-FKNYGCAV-K---DKRGNLQEHERSALRD HMLLVL--EKNFQLEEQISDLYKSL-EQKESKIQQLAEMV-KKFEKEFKQFAQLFGKNGS FLSNMQV------------LASHIDKSAWL------------EVQVRQLL--QMANQQQS KFD------------LKPLVEAIDTV-----------KQKIT-LLETN-------DQRLV VLEGE--------------------------TNKH-----D------------------- ------------------------------------------------------------ ------------AHINIHKAQLNKNEERFKLLESAC---------------YNGKLIWKV T-DYKLKKKEALDG-----HT--VSIFSQPFYTSRC-GYRL-------CARAYLN----- --------GDGSGK-GTHLSLYF---VVMR-----------GEFDSLL-----Q-WPFRQ R---VTLMLLDQSG----KK-NHIMETFKADPNSSS-FKRP------------DGEMNIA S-GCPR-------------------FVAHSTLENAKN-T--YIKDDTLFLKVAVDL---- ----------------TDL---------------------EDL >M_musculus_ENSMUSP00000082710 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MAHSEEQAAVPCAF IRQNSGNSISLDFEPDTEYQFVEQLEERYKCAFCHSVLHNPHQ-TGCGHRFCQQCIRSLR ----------ELNSVPICPVDK----------EVIK-PQEVFKDNCCKREVLNLHVYCKN ----------------APGCNARIILGRFQ--DH--LQHCSFQAVPCPNE-----SCREA MLRKDVKE----HLSAYCR---FREEKCLYCKRDIVVTNL-Q--DHEENSCPAYPVSCPN RCV---QTIPRARVNEHL-TVCPEAEQDCP-FKHYGCTV-K---GKRGNLLEHERAALQD HMLLVL--EKNYQLEQRVSRIIEAL-SRKQTHSQRLPLTA-PKKKKEHPALRPICSVSGT LVSSGKA------------LTSHTDKSAWL------------EAQVRQLL--QIVNQQPS RLD------------LRSLVDAVDSV-----------KQRIT-QLEAS-------DQRLV LLEGE--------------------------TSKH-----D------------------- ------------------------------------------------------------ ------------AHINIHKAQLNKNEERFKQLEGAC---------------YSGKLIWKV T-DYRVKKREAVEG-----HT--VSVFSQPFYTSRC-GYRL-------CARAYLN----- --------GDGSGK-GTHLSLYF---VVMR-----------GEFDSLL-----Q-WPFRQ R---VTLMLLDQSG----KK-NHIVETFKADPNSSS-FKRP------------DGEMNIA S-GCPR-------------------FVSHSTLENSKN-T--YIKDDTLFLKVAVDL---- ----------------TDL---------------------EDL >P_pygmaeus_ENSPPYP00000000253 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MAYSEEHKGMPCGF IRQNSGNSISLDFEPNIEYQFVERLEERYKCAFCHSVLHNPHQ-TGCGHRFCQHCILSLR ----------ELNTVPICPVDK----------EVIK-SQEVFKDNCCKREVLNLYVYCSN ----------------APGCNAKVILGRYQ--DH--LQQCLFQAVQCSNE-----KCREP VLRKDLKE----HLSAYCQ---FREEKCLYCKKDVVVINL-Q--NHEENLCPEYPVFCPN NCA---KIILKTEVDEHL-AVCPEAEQDCP-FKHYGCAV-T---DKRRNLQEHERSALRE HMRLVL--EKNVQLEEQISDLHKSL-EQKESKIQQLAETI-KKLEKEFKQFAQLFGKNGS FLPNIQV------------FASHIDKSAWL------------EAQVHQLL--QMVNQQQN KFD------------LRPLMEAVDTV-----------KQKIT-LLENN-------DQRLA VLEEE--------------------------TNKH-----D------------------- ------------------------------------------------------------ ------------THINIHKAQLSKNEERFKLLEGTC---------------YNGKLIWKV T-DYKMKKREAVDG-----HT--VSIFSQSFYTSRC-GYRL-------CARAYLN----- --------GDGSGK-GTHLSLYF---VVMR-----------GEFDSLL-----Q-WPFRQ R---VTLMLLDQSG----KK-N-IMETFKPDPNSSS-FKRP------------DGEMNIA S-GCPR-------------------FVAHSVLENAKN-A--YLKDDTLFLKVAVDL---- ----------------TDL---------------------EDL >P_troglodytes_ENSPTRP00000003288 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MAYSEEHKGMPCGF IRQNSGNSISLDFEPNIEYQFVERLEERYKCAFCHSVLHNPHQ-TGCGHRFCQHCILSLR ----------ELNTVPICPVDK----------EVIK-SQEVFKDNCCKREVLNLYVYCSN ----------------APGCNAKVILGRYQ--DH--LQQCLFQAVQCSNE-----KCREP VLRKDLKE----HLSAYCQ---FREEKCLYCKKDVVVINL-Q--NHEENLCPEYPVFCPN NCA---KIILKTEVDEHL-AVCPEAEQDCP-FKHYGCAV-T---DKRRNLQEHEHSALRE HMRLVL--EKNVQLEEQISDLHKSL-EQKESKIQQLAETI-KKLEKEFKQFAQLFGKNGS FLPNIQV------------FASHIDKSAWL------------EAQVHQLL--QMVNQQQN KFD------------LRPLMEAVDTV-----------KQKIT-LLENN-------DQRLA VLEEE--------------------------TNKH-----D------------------- ------------------------------------------------------------ ------------THINIHKAQLSKNEERFKLLEGTC---------------YNGKLIWKV T-DYKMKKREAVDG-----HT--VSIFSQSFYTSRC-GYRL-------CARAYLN----- --------GDGSGR-GTHLSLYF---VVMR-----------GEFDSLL-----Q-WPFRQ R---VTLMLLDQSG----KK-N-IMETFKPDPNSSS-FKRP------------DGEMNIA S-GCPR-------------------FVAHSVLENAKN-A--YIKDDTLFLKVAVDL---- ----------------TDL---------------------EDL >H_sapiens_ENSP00000336825 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MAYSEEHKGMPCGF IRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQ-TGCGHRFCQHCILSLR ----------ELNTVPICPVDK----------EVIK-SQEVFKDNCCKREVLNLYVYCSN ----------------APGCNAKVILGRYQ--DH--LQQCLFQPVQCSNE-----KCREP VLRKDLKE----HLSASCQ---FRKEKCLYCKKDVVVINL-Q--NHEENLCPEYPVFCPN NCA---KIILKTEVDEHL-AVCPEAEQDCP-FKHYGCAV-T---DKRRNLQQHEHSALRE HMRLVL--EKNVQLEEQISDLHKSL-EQKESKIQQLAETI-KKLEKEFKQFAQLFGKNGS FLPNIQV------------FASHIDKSAWL------------EAQVHQLL--QMVNQQQN KFD------------LRPLMEAVDTV-----------KQKIT-LLENN-------DQRLA VLEEE--------------------------TNKH-----D------------------- ------------------------------------------------------------ ------------THINIHKAQLSKNEERFKLLEGTC---------------YNGKLIWKV T-DYKMKKREAVDG-----HT--VSIFSQSFYTSRC-GYRL-------CARAYLN----- --------GDGSGR-GSHLSLYF---VVMR-----------GEFDSLL-----Q-WPFRQ R---VTLMLLDQSG----KK-N-IMETFKPDPNSSS-FKRP------------DGEMNIA S-GCPR-------------------FVAHSVLENAKN-A--YIKDDTLFLKVAVDL---- ----------------TDL---------------------EDL >M_mulatta_ENSMMUP00000038268 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MAYSEEHRGMPCGF IRQNSGNSISLDFEPNIEYQFVERLEERYKCAFCRSVLHNPHQ-TGCGHRFCQHCILSLR ----------ELNTVPICPVDK----------EVIK-SQEVFKDNCCKREVLNLYVYCSN ----------------APGCNAKVILGRYQ--DH--LQQCLFQAVQCSNE-----NCQEP VLRKDLKE----HLSAYCQ---FREEKCLYCKKDVVVINL-Q--NHEENLCPEYPVFCPN NCA---KIILKTEVDEHL-AVCPEAEQDCP-FKHYGCAV-T---DKRRNLQEHEHSALRE HMRLVL--EKNVQLEEQISDLHKSL-EQKESKIQQLAETI-KKLEKEFKQFAQLFGKNGS FLPNIQV------------FASHIDKSAWL------------EAQVHQLL--QMVNQQQN KFD------------LRPLMEAVDTV-----------KQKIT-LLENN-------DQRLA VLEEE--------------------------TNKH-----D------------------- ------------------------------------------------------------ ------------THINIHKAQLNKNEERFKLLEGTC---------------YNGKLIWKV T-DYKMKKREAVDG-----HT--VSIFSQSFYTGRC-GYRL-------CARAYLN----- --------GDGSGK-GTHLSLYF---VVMR-----------GEFDSLL-----Q-WPFRQ R---VTLMLLDQSG----KK-N-IMETFKPDPNSSS-FKRP------------DGEMNIA S-GCPR-------------------FVAHSVLENAKN-A--YIKDDTLFLKVAVDL---- ----------------TDL---------------------EDL >C_familiaris_ENSCAFP00000028895 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MAA ASVTPPGSLDLLQPGFSKTLLGTKPEDKYLCSACRNVLRRPFQ-AQCGHRYCSYCLSSIL -----------SSGPQNCAACV-HEGIYEEGISILE-SSSAFPDNAARREVESLPAVCPN -----------------NGCTWKGTLKEYE-SCH--EGHCPFMLTECP-------ACKGL VRLGEKEH----HSEHECP---ERSLSCRHCRAPCCWADL-K--AHHE-VCPKFPLTCDG -CGK--KKISREKFQDHV-RACGKCRVPCR-FHVVGCPE-M---VESEKQQQHEAHWLRE HLAMLL--GSLLEAKHLSGAG--------------------------------------- ----------------------GPFLGLKL------------QQRCEALE--RKTAT--- ---------------FENIVCVLNRE-----------VERVAMTAEACGRQHQLDQDRIE ALSNK--------------------------VQQL-----E------------------- ------------------------------------------------------------ ------------RTIGLKDLAMAELEQKVHEMEAST---------------FDGVFIWKI S-DFARKRQEAVAG-----RT--PAIFSPAFYTSRY-GYKM-------CLRIYLN----- --------GDGTGR-GTHLSLFF---VVMK-----------GPNDALL-----R-WPFNQ K---VTLMLLDQNN-----R-EHVIDAFRPDVTSSS-FQRP------------VSDMNIA S-GCPL-------------------FCPVSKMEAKNS----YVRDDAIFIKAIVDL---- ----------------TGL------------------------ >C_familiaris_ENSCAFP00000017853 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MAYSEDQGGVPCGF IRQNSSNSISLDFEPHTEYRFVEPLEERYKCALCHSVLHNPHQ-TGCGHRFCQHCILSLR ----------ELNAVPLCPVDK----------EVIK-SQEVFKDNCCKREVLNLYVYCKN ----------------APGCNAKIILGRYQ--QYIWLQYSTPRAKVRVNRRSIGTSCKHT MCRGSEGE----LLSHETA---LPGSSILLGKQEACILSLSQ--NHEENLCPEYPVPCPN KCS---QIIPRTEVDEHL-TVCPEAEQDCP-FKHYGCTV-K---DKRGSLQEHEHSALRD HMLLVL--EKNLQLEEQISDLYKSL-EQKESKIQQLAETV-KKFEKEFKQFAQLFGKNGS FLSNIQV------------LANHIDKSAWL------------EAQVRQLL--QMANQQQN KFD------------LRPLVEAIDTV-----------KQKIT-LLETN-------DQRLV VLEGE--------------------------TNKH-----D------------------- ------------------------------------------------------------ ------------AHINIHKAQLNKNEERFKLLEGAC---------------YNGKLIWKV T-DYKMKKREALDG-----HT--VSIFSQPFYTSRC-GYRL-------CARAYLN----- --------GDGSGK-GTHLSLYF---VVMR-----------GEFDSLL-----Q-WPFRQ R---VTLMLLDQSG----KK-NHIMETFKADPSSSS-FKRP------------DGEMNIA S-GCPR-------------------FVAHSTLENAKN-T--YIKDDTVFLKVAVDL---- ----------------TDL---------------------EDL >E_caballus_ENSECAP00000011150 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MAA ASVTPPGSLDLLQPGFSKTLLGTKLEDKYLCSACKNVLRRPFQ-AQCGHRYCSYCLTSIL -----------SSGPQNCAACV-HEGIYEEGISILE-SSSAFPDNAARREVESLPAVCPS -----------------DGCTWKGTLKEYE-SCH--EGHCPFMLTECP-------ACKGL VRLGEKEH----HLEHECP---ERSLSCRHCRAPCCWADM-K--AHHD-VCPKFPLTCDG -CGK--KKISREKFQDHV-RTCGKCRVPCR-FHAVGCPE-M---VESEKQQEHEAKWLQE HLAMLLDSSSFLGQSQVGNPG--------------------------------------- ---------------------AEVSKAAEL------------LQRCEALE--RKTAT--- ---------------FENIVCVLNRE-----------VERVAMTAEACGRQHRLDQDRIE ALSNK--------------------------VQQL-----E------------------- ------------------------------------------------------------ ------------RSIGLKDLAMADLEQKVHEMEAST---------------FDGVFIWKI S-DFTRKRQEAVAG-----RT--PAIFSPAFYTSRY-GYKM-------CLRIYLN----- --------GDGTGR-GTHVSLFF---VVMK-----------GPNDALL-----R-WPFNQ K---VTLMLLDQNN-----R-EHVIDAFRPDVTSSS-FQRP------------VSDMNIA S-GCPL-------------------FCPVSKMEAKNS----YVRDDAIFIKAIVDL---- ----------------TGL------------------------ >T_nigroviridis_ENSTNIP00000016461 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MAA QEPSPPSSMESNKPGFPKKILGNKLEDKHLCNCCHNILRRPFQ-AQCGHRFCSYCFTRTV -----------SNGPQKCSACI-KEDIFEDPTSILK-QGCAFPDNAVRREVEHLPAVCIN -----------------ENCTWKGTIKEYE-LSH--EGKCEFMIISCP-------SCKEH IRFNEQER----HNERECP---ERTLNCKYCKEPFHFKNI-K--AHDE-ICPKYPMICEG -CAK--KKIPREKYVDHI-KFCSKFRTPCR-FHVVGCDM-S---VEKEKIHDHERAFAYE HLNLLL--HYIMGMKASRAG---------------------------------------- ----------------------EKTKVAEL------------GRRCTELE--VKANT--- ---------------FENVVCVLNRE-----------VERFATTMEASNRQHKLDQDKIE ALSNK--------------------------VRQL-----E------------------- ------------------------------------------------------------ ------------RTVGLKDLTVAEMEGRLREMSATT---------------FDGVFVWRI S-DFAKKRQDAIAG-----RA--PAMFSPAFYTSKY-GYKM-------CLRIYLN----- --------GDGTGR-GSHLSLFF---VVMR-----------GQSDALL-----K-WPFNQ K---VTLMLLDQSN-----R-EHIIDAFRPDVTSSS-FQRP------------VSEMNIA S-GCPL-------------------FCPLSKLDGKNS----YIRDDTIFIKAIVDL---- ----------------TGL------------------------ >T_guttata_ENSTGUP00000002510 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MAA ANSSPPGSLDLNQPGFAKEILGTKLEVKYLCSDCKNILRRPFQ-AQCGHRYCSYCLKKII -----------SAGPQKCASCI-QEGIYEEGISILE-TSSAFPDNAARREVESLPAVCIN -----------------SGCNWKGTIKEYE-VQA--KARLGTSASFFP-------LC--- --LGKAQRVVCAHVGESCQ---IPGLYCQLEKFP-NVVHM-V--LHCE-ETPHCECSWRN -CEGIWKKHPGAAFRDHV-KTCGRSKVPCR-FEAVGCAE-V---VENEKLPEHERKCLAE HLYMLM--SSVLSLKTGAGDL--------------------------------------- -------------------------KPLPL------------LGRCEALE--RKTVT--- ---------------FENIVCVLNRE-----------VERVSLTAEAYSRQHRLDQEKIE TLSNK--------------------------VRQL-----E------------------- ------------------------------------------------------------ ------------RSIGLKDLAMAEMEEKIRNMEAST---------------YDGVFIWKI T-EFARKRQEAITG-----RS--PAIFSPAFYTSKY-GYKM-------CLRVYLN----- --------GDGTGR-GTHLSLFF---VVMK-----------GPNDALL-----R-WPFNQ K---VTLMLLDQNN-----R-EHIIDAFRPDVTSSS-FQRP------------VTEMNIA S-GCPL-------------------FCPVSVMEAKNS----YVRDDAIFIKAIVDL---- ----------------TGL------------------------ >E_caballus_ENSECAP00000005414 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MAYSEEQGGVPCGF IRQNSSNSVSLDFEPNTEYRFVEQLEERYKCAFCHSVLHNPHQ-TGCGHRFCQHCILSLR ----------ELNAVPLCPVDK----------EVIK-SQEVFKDNCCKREVLNLYVYCKN ----------------APGCNAKIILGRYQ--DH--LQQCLFQAVQCSNE-----HCQES VLRKNLKE----HLSAYCQ---FREEKCLYCKKDVVVINL-Q--NHEENMCPEYPVSCPN KCL---QIIPRTEVDEHL-AVCPEAEQDCP-FKQYGCPV-K---DKRGNLQEHEHSALRD HMLLVL--EKNLQLEKQISDLHRSL-ERKESKIQQLTETV-NKFEKEFKQFAQLFGKNGS FLSNIQL------------LASHLDKSAWL------------EAQVRQLL--QMANQQET KFD------------LRALMEAIDTV-----------KQKIT-LLETH-------DQRIV VLEGE--------------------------TNKH-----D------------------- ------------------------------------------------------------ ------------VHINIHKAQLNKNEERFKLLEGAC---------------YNGKLIWKV T-DYKMKKREALEG-----HT--VSIFSQPFYTSRC-GYRL-------CARAYLN----- --------GDGSGK-GTHLSLYF---VVMR-----------GEFDSLL-----Q-WPFRQ R---VTLMLLDQSG----KK-NHIMETFKADPNSSS-FKRP------------DGEMNIA S-GCPR-------------------FVAHSTLENAKN-T--YIKDDTIFLKVAVDL---- ----------------TDL---------------------EDL >M_domestica_ENSMODP00000003305 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------SLTSAEYGSASGDF LPQNSSSYISLDFEPNIDYQFVEQLEERYKCASCHSVLHNPHQ-TGCGHRFCENCILSLR ----------ELNTVSICPVDK----------EIIK-PKEVFKDNCCKREVLNLQVFCKN ----------------APHCAAKMILGRYQ--DH--LLQCLFQSVQCSNE-----CCQER ILRKDLKN----HLELHCQ---FREEMCPFCNKDVVIIDL-Q--NHKEQFCPNYPVSCPN NCL---QIITRTKVNEHI-SVCPEVEQECA-YKHYGCPV-K---DKRSNLKKHENSALRE HMLLVL--ERNSRLEEQIFDLHKNL-ELKESKIQQLSETV-KKFEKEFRQFVQLFGKNGN LLASTQV------------LASHIDKSAWL------------ETQVRELL--ELANQQEN KLD------------LKPLINTIDTI-----------KQKIT-LLETY-------DQRLV TLEGQ--------------------------TNRH-----D------------------- ------------------------------------------------------------ ------------VHINVHKAQLNKNEERFKMLEGTC---------------YNGKLIWKV T-DYKMKKKEATEG-----RT--VSIFSQPFYTSRC-GYRL-------CARAYLN----- --------GDGSGK-GTHLSLYF---VVMK-----------GEFDSLL-----Q-WPFKQ R---VTMMLLDQSG----KK-NHITEIFKADPNSSS-FKRP------------DGEMNIA S-GCPR-------------------FVAHSTLESTKN-T--YIKEDTLFMKVVVDL---- ----------------SDL---------------------EDL >M_musculus_ENSMUSP00000109872 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MAA ASVTSPGSLELLQPGFSKTLLGTRLEAKYLCSACKNILRRPFQ-AQCGHRYCSFCLTSIL ----RCASILSSSGPQNCAACV-YEGLYEEGISILE-SSSAFPDNAARREVESLPAVCPN -----------------DGCTWKGTLKEYE-SCH--EGLCPFLLTECP-------ACKGL VRLSEKEH----HTEQECP---KRSLSCQHCRAPCSHVDL-E--VHYE-VCPKFPLTCDG -CGK--KKIPRETFQDHV-RACSKCRVLCR-FHTVGCSE-M---VETENLQDHELQRLRE HLALLL--SSFLEAQASPGTL--------------------------------------- -----------------------NQVGPEL------------LQRCQILE--QKIAT--- ---------------FENIVCVLNRE-----------VERVAVTAEACSRQHRLDQDKIE ALSNK--------------------------VQQL-----E------------------- ------------------------------------------------------------ ------------RSIGLKDLAMADLEQKVSELEVST---------------YDGVFIWKI S-DFTRKRQEAVAG-----RT--PAIFSPAFYTSRY-GYKM-------CLRVYLN----- --------GDGTGR-GTHLSLFF---VVMK-----------GPNDALL-----Q-WPFNQ K---VTLMLLDHNN-----R-EHVIDAFRPDVTSSS-FQRP------------VSDMNIA S-GCPL-------------------FCPVSKMEAKNS----YVRDDAIFIKAIVDL---- ----------------TGL------------------------ >P_troglodytes_ENSPTRP00000036949 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MAA ASVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQ-AQCGHRYCSFCLASIL -----------SSGPQNCAACV-HEGIYEEGISILE-SSSAFPDNAARREVESLPAVCPS -----------------DGCTWKGTLKEYE-SCH--EGRCPLMLTECP-------ACKGL VRLGEKER----HLEHECP---ERSLSCRHCRAPCCGADV-K--AHHE-VCPKFPLTCDG -CGK--KKIPREKFQDHV-KTCGKCRVPCR-FHAIGCLE-T---VEGEKQQEHEAQWLRE HLAMLL--SSVLEAKPLSGDQ--------------------------------------- -----------------------SHAGSEL------------LQRCESLE--KKTAT--- ---------------FENIVCVLNRE-----------VERVAMTAEACSRQHRLDQDKIE ALSSK--------------------------VQQL-----E------------------- ------------------------------------------------------------ ------------RSIGLKDLAMADLEQKVLEMEAST---------------YDGVFIWKI S-DFARKRQEAVAG-----RT--PAIFSPAFYTSRY-GYKM-------CLRIYLN----- --------GDGTGR-GTHLSLFF---VVMK-----------GPNDALL-----R-WPFNQ K---VTLMLLDQNN-----R-EHVIDAFRPDVTSSS-FQRP------------VNDMNIA S-GCPL-------------------FCPVSKMEAKNS----YVRDDAIFIKAIVDL---- ----------------TGL------------------------ >D_rerio_ENSDARP00000091948 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------SG SASDPSLNGVSSTPGFPQSICDEVPKDKYLCSNCNNVLNKARQ-TVCGHRYCLACVNWLV ----------RNNKDLVCTKCKGEDSNVESDTSVLT-PNQFFNDVAINKEILDLKVHCAN -----------------QGCPWRSTLKNFE-QDH--QSQCEYALIPCNI------GCGIM VQRKTLAT----HLESGCP---NNKTACPSCTSVLTPRELQVLLKKEKHVCPS------- -SGDKKTAKTDKKQKNNQ-PANSKKKEPCI-FSDVGCPF-K---GNPDKVKEHESCSHAG HLQLLL--DVTRALQRTLNSATERVYQDSPVFLEPGPNGS--SLAPQADGDIETDGGDPG VELAA-------------------------------------GQQLDALQ--QKVQV--- ---------------IENIISALNRE-----------VEKTQISVVAMNRDHCNSQQIIQ HLEAT--------------------------VAEL-----Q------------------- ------------------------------------------------------------ ------------QRLVRKDILISSLQQSISAQQDVS---------------YDGTFYWRV C-DVSQKQREAANS-----QK--ISQYSPAFYTARY-GFKV-------CLRLYLN----- --------GDGAGK-GSHISLFF---VIMK-----------GEYDPIL-----S-WPFKH K---VTFFLLDQNQ-----R-EHVIDAFRPDLSSMS-FHQP------------VSDMNVA S-GCPL-------------------FFPLKKLRSPKH-A--YCKDDTIYIKCVVDT---- ----------------SS------------------------- >P_pygmaeus_ENSPPYP00000022191 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MAA ASVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQ-AQCGHRYCSFCLASIL -----------SSGPQNCAACV-HEGIYEEGISILE-SSSAFPDNAARREVESLPAVCPS -----------------DGCTWKGTLKEYE-SCH--EGRCPLMLTECP-------ACKGL VRLGEKER----HLEHECP---ERSLSCRHCRAPCCGADV-K--AHHE-VCPKFPLTCDG -CGK--KKIPREKFQDHV-KTCGKCRVPCR-FHAIGCLE-T---VEGEKQQEHEAQWLRE HLAMLL--SSVLEAKPLSGDQ--------------------------------------- -----------------------SHAGSEL------------LQRCESLE--NKTAT--- ---------------FENIVCVLNRE-----------VERVAMTAEACSRQHRLDQDKIE ALSSK--------------------------VQQL-----E------------------- ------------------------------------------------------------ ------------RSIGLKDLAMADLEQKVLEMEAST---------------YDGVFIWKI S-DFARKRQEAVAG-----RT--PAIFSPAFYTSRY-GYKM-------CLRIYLN----- --------GDGTGR-GTHLSLFF---VVMK-----------GPNDALL-----R-WPFNQ K---VTLMLLDQNN-----R-EHVIDAFRPDVTSSS-FQRP------------VNDMNIA S-GCPL-------------------FCPVSKMEAKNS----YVRDDAIFIKAIVDL---- ----------------TGL------------------------ >T_rubripes_ENSTRUP00000013348 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------MSAGRSTDGREVQIPLQQAAPSLAMPLSVAPL LTSHCVPAGFLPLHGGFRDHFVEALEAKYCCESCRLVLCQPRQ-TECGHRFCQSCINDIL -----------SHPNPVCPADT----------EPLF-KDKVFRDVCCHREIMALKVYCRS ---------------EANGCQEQMRLQQIP--DH--LNTCPFFEVPCPLG-----KCKER MMRKEIPE----HLSWKCK---YRETSCEFCMTKMPLTEL-Q--KHKETVCPAFPVSCPN HCSL--SSLPRSELSSHQ-HECPKAQVSCP-FHGYGCTF-K---GLNQVMRQHESSSAAE HLRMMA--KRNSALESKLDDVKGEL-LERFKVLPVLSSRV-AELESSNDELREKNRQTEQ KLGTMQKL-----------MSSHSEKLLEL------------ELELRSLR--GLRDE--- ---------------VENLRGTLESV-----------RTRLN-ALEQGGRSGSGSTHTLA SLEAQ--------------------------MNRH-----D------------------- ------------------------------------------------------------ ------------DMLSVHDIRLADMDLRFQVLETAS---------------YNGTLIWKI R-DYKRRKQEAVAA-----KT--LSLYSQPFYTGYF-GYKM-------CARIYLN----- --------GDGMGK-GTHLSLFF---VVMR-----------GEYDALL-----P-WPFKQ K---VTLMLMDQGP----LK-KHLGDAFKPDPNSSS-FRRP------------VVEMNIA S-GCPL-------------------FVSQSVLETGS-----YIKDDTIFIKVTVDT---- ----------------SDL---------------------PEP >M_domestica_ENSMODP00000021625 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MAT ANSTPPGSLDLLQPGFSKDILGTKLEDKYLCSACKNILRRPFQ-AQCGHRYCSYCLTSII -----------STGPQNCAACI-QEGIYEEGISILE-SSSAFPDNAARREVESLPAVCVN -----------------DGCTWKGTIKEYE-SCH--EGHCSFMLIECP-------ACKWM IKLGEKEH----HSERECP---KRSLNCRYCKALFYYPDI-K--AHDE-ICPKFPLTCEG -CGK--KKILREKFQDHV-KACGKCKGPCK-FHVVGCTE-M---VENEKQQDHENQKVAE HLCMLL--NFVLEARHFHGDI--------------------------------------- ----------------------EMSKSTEL------------LERCETLE--RKTVT--- ---------------FENIVCVLNRE-----------VERVSMTAEACSRQHRLDQEKIE TLSSK--------------------------VQQL-----E------------------- ------------------------------------------------------------ ------------RSIGLKDLAMADMEQKILEMEAST---------------YDGIFIWKI T-DFARKRQEAMAG-----RS--PAIFSPAFYTSKY-GYKM-------CLRIYLN----- --------GDGTGR-GTHLSLFF---VVMK-----------GPNDALL-----R-WPFNQ K---VTLMLLDQNN-----R-EHVIDAFRPDVTSSS-FQRP------------VSDMNIA S-GCPL-------------------FCPVSKMESKNS----YVRDDAIFIKAIVDL---- ----------------TGL------------------------ >R_norvegicus_ENSRNOP00000010906 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MEPSKKMGAAGAAQPNPPLKLQ PDRGAA-SVLVPEQGGYKEKFAKTVEDKYKCEKCRLVLCNPKQ-TECGHRFCESCMAALL -----------SSSSPKCTACQ----------ESII-KDKVFKDNCCKREILALQIYCRN ---------------EGRGCVEQLTLGHLL--VHL-KNECQFEELPCLRA-----DCKEK VLRRDLRD----HVEKACK---YREATCAHCKSQVPMITL-Q--KHEDTDCPCVVVSCPH KCSV--QTLLRSELSAHL-SECVNAPSTCS-FKRYGCVF-Q---GTNQQIKAHEASSAVQ HVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQI-CSFEIEIERQKEMLRNNES KILHLQRV-----------IDSQAEKLKEL------------DKEIRPFR--QNWEE--- ---------------ADSMKSSVESL-----------QNRVT-ELESVDKSAGQAARNTG LLESQ--------------------------LSRH-----D------------------- ------------------------------------------------------------ ------------QMLSVHDIRLADMDLRFQVLETAS---------------YNGVLIWKI R-DYKRRKQEAVMG-----KT--LSLYSQPFYTGYF-GYKM-------CARVYLN----- --------GDGMGK-GTHLSLFF---VIMR-----------GEYDALL-----P-WPFKQ K---VTLMLMDQGS----SR-RHLGDAFKPDPNSSS-FKKP------------TGEMNIA S-GCPV-------------------FVAQTVLENGT-----YIKDDTIFIKVIVDT---- ----------------SDL---------------------PDP >G_gallus_ENSGALP00000002401 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------PRA GPAGGPGADAAVLPGGSRRGVGDVPEQKYLCSNCNNVLKKALQ-TLCGHRYCSACLSWIV ----------RNNKNPVCQKCKEEDPSTLSEGSLLA-EERAFGDAAINKEISELRVHCVT -----------------LGCSWCGTMKNFE--EH--QILCEYALIPCHT------GCGHV VMRKKLAD----HLENGCV---NNVTVCHKCKQSLSSSEY-Q--PH----CPRKPKVCRS EPAV--ILMTGTFMLSDHLRASSVSMDGCR-FSEVGCSF-G---GSKEKIKEHEKAAVGT HMLLLL--QYIKQLKANLCTVSK------------------------------------- -------------------AANGFISQTEL------------N-----LE--NKLHV--- ---------------FENIVAVLNKE-----------VETSNLEITAFRRQSELDQNVIR GLELK--------------------------IAEL-----H------------------- ------------------------------------------------------------ ------------HCLTQKDAGLSRLHKSLVFSEQTS---------------YDGVFLWKI T-DVNQKLQDSVTG-----RV--VSLYSPAFYTAKY-GYKV-------CLRIYLN----- --------GDGMGK-GTHVSLFF---VVMK-----------GDYDALL-----P-WPFRH K---VTFMLLDQNN-----R-EHIIDAFRPDLASAS-FQRP------------VNDMNVA S-GCPT-------------------FLPLTKLQSPKH-A--YVKEDTLFLKCIIDL---- ----------------TAV------------------------ >T_guttata_ENSTGUP00000006737 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------DVPGHKFLCSNCNNILKKALQ-TLCGHRYCSACLAWIL ----------RNNKNAICQKCKEEDPNTLGEESLLA-EERAFGDAAINKEISELRVHCVT -----------------LGCSWSGIMKDFE--EH--QSLCEYALIPCHT------GCGHV VMRRKLAD----HLENGCV---NNVTVCQQCQCSLATSEC-Q--VR----TFLSQ--IKA FQLV--LIISSTFFFSSH-STSSSNKDGCC-FSEVGCAF-R---GSKEKIQEHQNSAVGA HMLLLL--QHMRQLQGTLC----------------------------------------- --------------------SKGFSPRPEL------------NKVISELE--NKLHV--- ---------------FENIVAVLNKE-----------VESSNLEIQAFRRQSELDQNVIR GLELK--------------------------IAEL-----H------------------- ------------------------------------------------------------ ------------QCLTQKDAGLSSLHKSLLFSEQAS---------------YDGIFLWKI T-EVARKLQDSVTG-----RT--VSLYSPAFYTAKY-GYKV-------CLRVYLN----- --------GDGTGK-GTHMSLFF---VVMK-----------GDYDALL-----P-WPFRH K---VTFMLLDQNN-----R-EHIIDAFRPDLTSAS-FQRP------------VNDMNVA S-GCPM-------------------FLPLAKLQSPKH-G--YVREDTLFLKCIIE----- ------------------------------------------- >T_rubripes_ENSTRUP00000015632 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------TDAMAT QEPSPPSSMESNKPGFPKKILGNKLEDKHLCNCCHNILRRPFQ-AQCGHRFCSYCFNRTV -----------SNGPQKCSACI-KRILWFQ----------AFPDNAVRREVEHLPAACIN -----------------ENCTWKGTIKEYE-LNH--EGKCEFMIISCP-------SCKEH IRFNEQER----HNERECP---ERTLNCKYCKEPFHFKNI-K--AHDE-ICPKYPMICEG -CAK--KKIPREKYVDHI-KFCSKFRTPCR-FHVVGCDM-S---VEKEKIHDHERAYAYE HLNLLL--HYIMGMKVSMEGLQPQGLEVAGQKLVELQQSL-RELELSVSTSFTPLPSSVG AALELQ-------------LHSEKTKVAEL------------GRRCTELE--VKANT--- ---------------FENVVCVLNRE-----------VERFATTMEASNRQHKLDQDKIE ALSNK--------------------------VRQL-----E------------------- ------------------------------------------------------------ ------------RTVGLKDLTVAEMEGRLREMSATT---------------FDGVFVWRI S-DFAKKRQDAIAG-----RA--PAMFSPAFYTSKY-GYKM-------CLRIYLN----- --------GDGTGR-GSHLSLFF---VVMR-----------GQSDALL-----K-WPFNQ K---VTLMLLDQSN-----R-EHIIDAFRPDVTSSS-FQRP------------VSEMNIA S-GCPL-------------------FCPLSKLDGKNS----YIRDDTIFIKAIVDL---- ----------------TGL------------------------ >T_guttata_ENSTGUP00000013203 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAN PDRSPSASIYVPEQGGYKEKFVNAVEDKYKCEKCHLILCNPKQ-TECGHRFCETCMNALL -----------RSSSPKCTACQ----------ESIV-KDKVFKDNCCRRELLALQIYCRN ---------------ENKGCKEQLSLGQLL--MHL-RTDCQFEELPCPRA-----DCKEK ILRKDLPD----HVEKTCK---YRETTCKYCKSQVPMIML-Q--KHEDTECPCVMVSCPH KCSV--KTLMRSELNAHL-SECINAPSTCS-FKRYGCTF-Q---GTNQQIKAHEASSAVQ HVNLLK--EWSNALENKVALLQNES-LEKNKSIQTLHNQI-CSFEIEIERQKEMLRNNES KILHLQRV-----------IDSQAEKLKEL------------DKEIRPFR--QNWEE--- ---------------ADSMKSSVESL-----------QNRVT-ELESVDKTAGQGARNTS LLETQ--------------------------LSRH-----D------------------- ------------------------------------------------------------ ------------QMLSVHDIRLADMDLRFQVLETAS---------------YNGVLIWKI R-DYKRRKQEAVMG-----KT--LSLYSQPFYTGYF-GYKM-------CARVYLN----- --------GDGMGK-GTHLSLFF---VIMR-----------GEYDALL-----P-WPFKQ K---VTLMLMDQGP----SR-RHLGDAFKPDPNSSS-FKKP------------TGEMNIA S-GCPV-------------------FVAQTVLENGT-----YIKDDTIFIKVIVDT---- ----------------SDL---------------------PDP >X_tropicalis_ENSXETP00000027864 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MDTGKKTD-PSASV----QKAN PDRSLATTIYVPEQGGYKERFLKPVEEKYKCEKCRLVLCNPRQ-TECGHRFCETCMNAIL -----------SSTSPQCMACE----------DNIT-KDKVFKDNCCRREVLALQMFCRN ---------------ETRGCKELITLGNLL--IHL-KSDCQFEELSCPRA-----DCKEK VIRKDLSD----HIEKTCK---YRETPCKFCRNQVPLVEM-Q--KHEDVDCPSVVISCPH MCSV--KSLLRSELNAHL-LECVNAPSTCS-FKRYGCTF-K---GTNQQIKAHEASSAVQ HVNLMK--EWSNYLEAKVSMLQNES-SEKNKSIQILHNQM-CSFEIEIERHKEQLRNNEA RIIQLQRV-----------IEGQADKLKDL------------DKEIRNLR--QTGDE--- ---------------ADGMKSNYESL-----------QNRLS-QLEVMAKNA--ASWNPG VLETQ--------------------------INRH-----D------------------- ------------------------------------------------------------ ------------QMLSVHDIRLADMDLRFQVLETAS---------------YNGVLIWKI R-DYKRRKQEAVMG-----KT--LSLYSQPFYTGYF-GYKM-------CARVYLN----- --------GDGMGK-GTHLSLFF---VIMR-----------GEYDALL-----P-WPFKQ K---VSLMLMDQGP----SR-RHLGDAFKPDPNSSS-FKKP------------TGEMNIA S-GCPV-------------------FVAQTVLENGT-----YIKDDTIFIKVIVDT---- ----------------SDL---------------------PDP >X_tropicalis_ENSXETP00000031605 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------IMACEDLCPLPVTL GRQNSSAAVSLDFVPKQEYLFVEQLQDRYKCASCHLVLHNPHQ-TGCGHRFCEKCISNLI ----------ELSETPQCPIDM----------ENIK-SHEIFKDNCCKREVLNLLVYCKN ----------------SPACDVKVMLGRYQ--EH--LGQCLYEMTLCSND-----GCHDQ MIRKELKG----HLESECK---LRQEACIYCKQTMASINL-T--IHVGLYCQLYPVPCPN ACP---VTCPRAELDKHL-CECPEAELQCT-FSNYGCNV-M---VKRGKVKEHEDTFLRD HMLYVL--NRNMKLEEQVLGLQQNL-DLKEHQIQQLSDTV-KWCEKECHQFGQFTGSNGN SLSSTKT------------LASYIDKSMWL------------EEQV---I--QLVSKEHS RLD------------LRPILDTLEST-----------KQRLS-TLEAY-------KDRID NLDGQ--------------------------FKKH-----D------------------- ------------------------------------------------------------ ------------VLLSNHKMQMTSNEERFRLVEGTS---------------YNGKLIWKI T-DYERKKREAMEG-----RA--VSIFSQHFYTSWC-GYRL-------CARAYLN----- --------GDGSGK-GSFLSLYF---VVMK-----------GEFDSIL-----L-WPFKQ K---VTLMLLDQSG----KK-NHITDVFRADPNSSS-FKRP------------DSEMNIA S-GCPR-------------------FASHAQLENPKNGC--YIK---------------- ------------------------------------------- >T_nigroviridis_ENSTNIP00000005138 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --PAGGPAGFQPLHGGFRDHFVEAPEAKYCCESCRLVLCQPRQ-TECGHRFCQSCITQLL -----------GHANPVCPADM----------EPLF-KDKIFRDVCCHREIMALKVYCRS ---------------EANGCQEQMRLQQIP--DH--LNVCPFFEVPCPLG-----KCKER MMRKEIPD----HLSWKCK---FRESSCEFCMTKMPLTEL-Q--KHKETVCPAFPVSCPN HCSF--SSLPRSELSNHQ-HECPKAQVSCQ-FHGYGCTF-K---GLNQLMRQHESTSAAE HLRMMA--KRNSMLEGKLDDVKGEL-LERLKHLPVVSSRV-SELENASDELREKNRQMEQ KLATMQKL-----------MSSHSEKLLEV------------ELELRALR--GLRDE--- ---------------VENLRGSLEGF-----------RTRLS-ALEQGGRGGSGSTHTLA SLEAQ--------------------------MNRH-----D------------------- ------------------------------------------------------------ ------------DMLSVHDIRLADMDLRFQVLETAS---------------YNGTLIWKI R-DYKRRKQEAVAA-----KT--LSLYSQPFYTGYF-GYKM-------CARIYLN----- --------GDGMGK-GTHLSLFF---VVMR-----------GEYDALL-----P-WPFKQ K---VTLMLMDQGP----LK-KHLGDAFKPDPNSSS-FRRP------------VVEMNIA S-GCPL-------------------FVSQSVLETGS-----YIKDDTIFIKVTVDT---- ----------------SDL---------------------PEP >H_sapiens_ENSP00000247668 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MAA ASVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQ-AQCGHRYCSFCLASIL -----------SSGPQNCAACV-HEGIYEEGISILE-SSSAFPDNAARREVESLPAVCPS -----------------DGCTWKGTLKEYE-SCH--EGRCPLMLTECP-------ACKGL VRLGEKER----HLEHECP---ERSLSCRHCRAPCCGADV-K--AHHE-VCPKFPLTCDG -CGK--KKIPREKFQDHV-KTCGKCRVPCR-FHAIGCLE-T---VEGEKQQEHEVQWLRE HLAMLL--SSVLEAKPLLGDQ--------------------------------------- -----------------------SHAGSEL------------LQRCESLE--KKTAT--- ---------------FENIVCVLNRE-----------VERVAMTAEACSRQHRLDQDKIE ALSSK--------------------------VQQL-----E------------------- ------------------------------------------------------------ ------------RSIGLKDLAMADLEQKVLEMEAST---------------YDGVFIWKI S-DFARKRQEAVAG-----RI--PAIFSPAFYTSRY-GYKM-------CLRIYLN----- --------GDGTGR-GTHLSLFF---VVMK-----------GPNDALL-----R-WPFNQ K---VTLMLLDQNN-----R-EHVIDAFRPDVTSSS-FQRP------------VNDMNIA S-GCPL-------------------FCPVSKMEAKNS----YVRDDAIFIKAIVDL---- ----------------TGL------------------------ >A_carolinensis_ENSACAP00000006987 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------A--------S ANVTPPGSLDEDQVGFPKEILGTELEGKYLCSECGNILRRPFQ-AQCGHRYCASCLQRLI -----------SSGPQKCGACI-QEGIYEDGVSILE-TGSAFPDNAARREVESLPAICAN -----------------EGCAWKGTIKEYE-SGH--GGSCPWALATCP-------SCRGP VRRRDQER----HAARECP---QRSLSCKFCKALCHFPQI-K--AHDE-VCPKFPLTCEG -CGK--RKIPREKFPEHV-KSCSKCKAPCR-FQPIGCNV-V---VSPSRWDE-AGPIIYK YC---------------------------------------------------------- ------------------------------------------------------------ ------------------IIHYSNWI-----------WGRVRVTLPSF----------LP SLW-Q--------------------------VRQL-----E------------------- ------------------------------------------------------------ ------------RSLASKDLALAEMEHSLQEMEAAS---------------FDGIFIWKI S-DFTKKRQ-AVAG-----RS--PAIFSPAFYTGKY-GYKM-------CLRIYLN----- --------GDGTGR-GTHLSLFF---VVMR-----------GPCDALL-----R-WPFNQ K---V------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------- >T_guttata_ENSTGUP00000003276 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MACDEPAALSGIF TRQNSSSTSSLDFEPHADYRFVESLEERYKCAYCHLVLRNPHQ-TGCGHRFCQQCILALR ----------ELNAVPTCPVDK----------ETIK-MHEVFKDNCCKREVLNLHVFCKN ----------------FPDCSSKVILGRYQ--EH--LQQCLFECTQCTND-----GCRDR VLRKDLKE----HLRQQCK---FREERCQYCNTYVVFINI-E--NHEKNDCPDYPVPCLQ NCS---QIILKKEIEKHH-AVCPEAEVDCP-YKQYGCHV-K---VKRGKLAEHENSALRE HMLQIL--DKNSRLEEQISDLYKNL-EYKEIKIQQLADAI-KKCEKEFRQYTQLFGNNSN LMVSTQA------------LASHLDKSARL------------ESQVKQLI--QMANQQQS KLD------------LQPLLDTIENV-----------KQKIA-LMETY-------DQRLV VLEDQ--------------------------SSKH-----D------------------- ------------------------------------------------------------ ------------LQINIHKAQLNKNEERFKLLEGTC---------------YNGKLIWKI T-DYQKKKREAVEG-----RV--LSIASQPFYTSRC-GYRL-------CARAYLN----- --------GDGSGK-GTHISLYF---VVMR-----------GEFDSLL-----L-WPFKQ K---VTLMLLDQSG----KK-NHIVDVFRADPNSSS-FKRP------------DGEMNIA S-GCPR-------------------FVPHTVLESTKN-T--YIRDDTLFLKVVVDL---- ----------------TDL---------------------EEL >B_taurus_ENSBTAP00000013869 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MAA ASVTPPGSLDLLQPGFSKTLLGTKLEDKYLCSACKNVLRRPFQ-AQCGHRYCSFCLSSIL -----------SSGPQSCAACV-HEGIYEEGVSILE-SSSAFPDNAARREVESLPAVCPS -----------------EGCSWKGTLKDYE-SCH--EGQCPFMLTECP-------ACKGL VRLGEKEH----HLEHQCP---ERSLSCRHCRAPCSPADM-K--AHHQ-ICPKFPLTCDG -CGK--KKIAREKFQDHV-RACGRCRVPCR-FHAVGCPE-M---VESEQQPEHEAQRLQE HLALLL--GVLLEAGRPPGDS--------------------------------------- ---------------------RLLLRVAEL------------LQRCEALE--RKTAT--- ---------------FENIVCVLNRE-----------VERVAVTAEACGRQHRLDQDRIE ALSNK--------------------------VQQL-----E------------------- ------------------------------------------------------------ ------------RSIGLKDLAMADLEQKVLEMEAST---------------FDGVFIWKI S-DFSRKRQEAVAG-----RT--PAIFSPAFYTSRY-GYKM-------CLRAYLN----- --------GDGTGR-GTHLSLFF---VLMR-----------GPHDALL-----R-WPFNQ K---VTLMLLDQNN-----R-EHVIDAFRPDVTSSS-FQRP------------VGDMNIA S-GCPL-------------------FCPVSKMEAKNS----YVRDDAIFIKAIVDL---- ----------------TGL------------------------ >D_rerio_ENSDARP00000043465 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A QEPSPPSSLEGNKPGFPKKILANKLEDKHLCNICLKILRRPFQ-AQCGHRFCSYCFNKAV -----------SKDKKVCTTVV----------IMKK-KKKAFPDNAAKREVEALEAVCIN -----------------EECSWTGTIKEYE-ANH--EGKCDFRILPCP-------SCKEL LRANELER----HNERECP---ERTLNCKYCKEPFHFKNI-K--AHDE-ICPKYPMICEG -CAK--KKIPREKYVDHI-KLCTKFRTPCR-FHVVGCDM-T---VEKEKIHDHEQACSYE HLNLLL--HFIMGIKVNLESLQPQSLELASHKIHELHQSL-RELE--------------- ------------------------------------------LKMGQELE--LKVNT--- ---------------FENIVCVLNRE-----------MERSATTMEAYNRQHRLDQDKIE ILNNKIESNQGIKCEADNSCFSPRNYWMFVQVRQL-----E------------------- ------------------------------------------------------------ ------------RTVGLRDLSIVEMEAKMREMSAAT---------------YDGVFVWKI S-DFSKKRQDAVAG-----RA--PAMFSPAFYTSKY-GYKM-------CLRIYLN----- --------GDGTGR-GTHLSLFF---VVMR-----------GHSDALL-----K-WPFNQ K---VTLMLLDQNN-----R-EHIIDAFRPDISSSS-FQRP------------VSDMNIA S-GCPL-------------------FCPLSKLDSKNS----YIRDDTIFIKAIVDL---- ----------------TGL------------------------ >G_gallus_ENSGALP00000036699 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAN PDRSPSASIYVPEQGGYKEKFVNAVEDKYKCEKCHFILCNPKQ-TECGHRFCETCMNALL -----------STPSPKCTACQ----------ESIV-KDKVFKDNCCRRELLALQIYCRN ---------------ENKGCKEQLSLGQLL--MHL-KTDCQFEELPCPRA-----DCKEK ILRKDLPD----HVEKTCK---YRETTCKYCKSQVPMIML-Q--KHEDTDCPCVMVSCPH KCSV--KTLMRSELNAHL-SECINAPSTCS-FKRYGCTF-Q---GTNQQIKAHEASSAVQ HVNLLK--EWSNALENKVALLQNES-LEKNKSIQTLHNQI-CSFEIEIERQKEMLRNNES KILHLQRV-----------IDSQAEKLKEL------------DKEIRPFR--QNWEE--- ---------------ADSMKSSVESL-----------QNRVT-ELESVDKTAGQGARNTS MLETQ--------------------------LSRH-----D------------------- ------------------------------------------------------------ ------------QMLSVHDIRLADMDLRFQVLETAS---------------YNGVLIWKI R-DYKRRKQEAVMG-----KT--LSLYSQPFYTGYF-GYKM-------CARVYLN----- --------GDGMGK-GTHLSLFF---VIMR-----------GEYDALL-----P-WPFKQ K---VTLMLMDQGP----SR-RHLGDAFKPDPNSSS-FKKP------------TGEMNIA S-GCPV-------------------FVAQTVLENGT-----YIKDDTIFIKVIVDT---- ----------------SDL---------------------PDP >D_rerio_ENSDARP00000056877 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MPGLDLKFLERPRRKFYCPLCEKPMREPVQVSTCGHRFCDTCLQEYL -----------SEGVFTCPEDQ----------LPLD-YAKIFPDLELEQQILSLPIRCIH ---------------SEEGCRWTAQNKLLQ--AH--LSVCEFNVVSCPN------RCSVK LLRRELPE----HLQHDCA---KRKLHCDHCGEQFTGEAY-E--NHQG-VCPEESVYCEN KCG---ARMVRRLLAQHSVSECLKRKLPCR-Y----CKK-E---FLYDTIQNHQQQCPRF PMQCPNRCGTPGITRDTLMAHVKEGCSTAMVLCPFKEAGC-------------------- ------------------------------------------KHRSPKTGVARHLEE--- ------------------------------------------------------------ AAPTH--------------------------LSLL-----C------------------- ------------------------------------------------------------ ------------GLVNRQRLELRDLRRRMEELSGS----------------RDGTLLWKL T-DFSQRLQEAKTR-----TSGCLELFSPAFYSHNY-GYRL-------QVSAFLN----- --------GNGSGE-DTHMSVYL---RVLP-----------GEYDGLL-----E-WPFPY R---VSFSLLDQCDPALTKP-QHITETFSPDPTWKN-FQRPRPGALGSIRGGCLDESMLG F-GYPK-------------------FISHEEMKKR---N--YIRDNAVFIKASIDVVQKI LN----------------------------------------- >A_carolinensis_ENSACAP00000016112 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MASEDLACQVPNFY IRQNSTNAVSLDFEPDASYQFVEILEDRYKCTHCHLVLHNPHQ-TGCGHRFCQRCIASLR ----------ELSVIPTCPVDK----------EIIK-PHEVFKDNCCKREVLNLQVYCRN ----------------SPACNAKTSLGRYQ--DH--LQQCLFESVQCTNE-----GCCEK VLQKDLKE----HLGLHCN---YRKELCRYCNQPVTSINV-K--THERRDCPEYPLICPH GCT---QTILMKEAEEHI-LVCPAVEIDCP-YKQYGCPA-K---IKRGKVLEHENIYLRE HMLQIL--DRNSKLEDQISELYKNL-EHKEIKIQHLADMV-KKCEKEFRQFTQLYSKNNN LLASTQT------------LAIHIDKSACL------------ETQVRQLV--QMANQQQS KFD------------LRPLLETVENI-----------KQKVA-FLESY-------EQRLV VLEDL--------------------------SSQH-----D------------------- ------------------------------------------------------------ ------------IHLGLHKAQLNKNEERFKLLEGTS---------------YNGKLIWKI V-DYKTKKKEAVEG-----SC--LSIFSQPFYTSRC-GYRL-------STRAYLN----- --------GDGSGK-GTHVSLYF---VVMR-----------GEFDSLL-----P-WPFRQ K---VTLMLLDQSG----KK-NHIVETFKADPNSSS-FKRP------------EGEMNVA S-GCPR-------------------FVPHTLLENAKS-T--YIKDDTIFLKVVVDL---- ----------------TDL---------------------EEL >O_latipes_ENSORLP00000003220 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MAA LEPSPPSSMESNKPGFPKKILGNKLEDKHLCNCCHNILRRPIQ-AQCGHRFCSYCFNRTV -----------SNGPQKCNACI-KEEIFEEPTSILK-QGCAFPDNAVRREVEGLSADCIN -----------------ENCPWKGTIKEYE-LDH--EGKCEFMIIPCP-------SCKER IRFSEQER----HSERECP---ERTLNCKYCKEPFHFKNI-K--AHDE-ICPKYPMICEG -CAK--KKIPREKYVDHI-KFCSKFRTPCR-FHVVGCDM-S---VEKEKIHDHERAFAYE HLNLLL--HYIMGMKVSMEGLQPQGLETAGHKLVELQKSL-RDLEARVSQLST---TSSG P----------------------PVQGAAA------------SSSSSRLE--VKSGT--- ---------------FENVVCVLNRE-----------VERFTTTMEASNRQHKLDQDKIE ALSNK--------------------------VRQL-----E------------------- ------------------------------------------------------------ ------------RTVGLKDLTVAEMEGRLREMAATT---------------FDGVFIWRI S-DFAKKRQDAVAG-----RA--PAMFSPAFYTSKY-GYKM-------CLRIYLN----- --------GDGTGR-GTHLSLFF---VVMR-----------GLSDALL-----K-WPFNQ K---VTLMLLDQSN-----R-EHIIDAFRPDVTSSS-FQRP------------VSEMNIA S-GCPL-------------------FCPLSKLDAKNS----YIRDDTIFIKAIVDL---- ----------------TGL------------------------ >G_gallus_ENSGALP00000014649 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MAA ANSTPPGSLDLSQPGFAKEILGTKLEVKYLCSDCRNILRRPFQ-AQCGHRYCSYCLKKII -----------SSGPQKCASCI-QEGIYEEGISILE-TSSAFPDNAARREVESLPAVCIN -----------------EGCTWKGTIKEYE-SCH--EGNCPFLLIECQ-------ACRGV IPLNEKER----HSERECP---ERTLNCKYCKSLFYFPDI-K--AHDE-VCPKFPLTCDG -CGK--KKIPREKFQDHV-KNCGKCKVPCR-FKVVGCAE-M---VENEKLPEHESKCLAE HLYMLL--SFVLSLKSGSGDLKHLPAIPSSQSSSPLLAAN-------------------- ------SLC----------PESELFKSLEL------------LGRCDALE--KKTVT--- ---------------FENIVCVLNRE-----------VERVSLTAEAYSRQHRLDQEQIE TLSNK--------------------------VRQL-----E------------------- ------------------------------------------------------------ ------------RSIGLKDLAMAEMEEKIRNMEAST---------------YDGVFIWKI T-EFARKRQEAITG-----RS--PAIFSPAFYTSKY-GYKM-------CLRVYLN----- --------GDGTGR-GTHLSLFF---VVMK-----------GPNDALL-----R-WPFNQ K---VTLMLLDQNN-----R-EHIIDAFRPDVTSSS-FQRP------------VTEMNIA S-GCPL-------------------FCPVSVMEAKNS----YVRDDAIFIKAIVDL---- ----------------SGL------------------------ >G_gallus_ENSGALP00000016021 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MACDELTGVSGIF TRQNSASAVSLDFEPDTDYKFVETLEDRYKCAYCHSVLHNPHQ-TGCGHRFCQQCILTLR ----------GLNAVPTCPVDK----------ETIK-MHEVFKDNCCKREVLNLYVFCKN ----------------LPDCNSKIILGRYQ--EH--LQQCLFESVQCTND-----GCCDQ ILRKDLKD----HLSQHCK---FREEMCQYCNKYVVLINI-K--NHEENDCPDYPMPCLQ NCS---QIILKKEIEKHH-TVCPETEVDCP-YKQYGCLI-K---VKRGKLAEHENGALRE HMLQIL--DKNSRLEEQISDLYKSL-ECKEIKIQQLAEAV-KKCEKEFRQFTQLFGKNSN LMVSTQT------------LASHLDKSARL------------ESQVKQLI--QMANQQQS KLD------------LRPLFDTIENV-----------KQKIA-LMETY-------DQRLA VLESQ--------------------------SSKH-----D------------------- ------------------------------------------------------------ ------------LQINIHKAQLNKNEERFKLLEGTC---------------YNGKLIWKI T-DYKMKKKEAVEG-----RV--LSIFSQPFYTSRC-GYRL-------CARAYLN----- --------GDGSGK-GTHVSLYF---VVMR-----------GEFDSLL-----P-WPFKQ K---VTLMLLDQTG----KK-NHIVEVFRADPNSSS-FKRP------------DGEMNIA S-GCPR-------------------FVPHTVLENTKN-T--YVRDDTLFLKVVVDL---- ----------------TDL---------------------EEL >M_musculus_ENSMUSP00000021706 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MESSKKMDAAGTLQPNPPLKLQ PDRGAG-SVLVPEQGGYKEKFVKTVEDKYKCEKCRLVLCNPKQ-TECGHRFCESCMAALL -----------SSSSPKCTACQ----------ESII-KDKVFKDNCCKREILALQVYCRN ---------------EGRGCAEQLTLGHLL--VHL-KNECQFEELPCLRA-----DCKEK VLRKDLRD----HVEKACK---YREATCSHCKSQVPMIKL-Q--KHEDTDCPCVVVSCPH KCSV--QTLLRSELSAHL-SECVNAPSTCS-FKRYGCVF-Q---GTNQQIKAHEASSAVQ HVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQI-CSFEIEIERQKEMLRNNES KILHLQRV-----------IDSQAEKLKEL------------DKEIRPFR--QNWEE--- ---------------ADSMKSSVESL-----------QNRVT-ELESVDKSAGQAARNTG LLESQ--------------------------LSRH-----D------------------- ------------------------------------------------------------ ------------QMLSVHDIRLADMDLRFQVLETAS---------------YNGVLIWKI R-DYKRRKQEAVMG-----KT--LSLYSQPFYTGYF-GYKM-------CARVYLN----- --------GDGMGK-GTHLSLFF---VIMR-----------GEYDALL-----P-WPFKQ K---VTLMLMDQGS----SR-RHLGDAFKPDPNSSS-FKKP------------TGEMNIA S-GCPV-------------------FVAQTVLENGT-----YIKDDTIFIKVIVDT---- ----------------SDL---------------------PDP >M_mulatta_ENSMMUP00000015419 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MESSKKMDSPGPLQTNPPLKLH TDRSAGTPIFAPEQGGYKEKFVKTVEDKYKCEKCRLVLCSPKQ-TECGHRFCESCMAALL -----------SSSSPKCTACQ----------ESVV-RDKVFKDNCCKREILALQIYCRN ---------------ESRGCAEQLTLGHLL--VHL-KNDCHFEELPCVRA-----DCKEK VLRKDLRD----HVEKACK---YREATCSHCKSQVPMIAL-Q--KHEDTDCPCVVVSCPH KCSV--QTLLRSELSAHL-SECVNAPSTCS-FKRYGCVF-Q---GTNQQIKAHEASSAVQ HVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQI-CSFEIEIERQKEMLRNNES KILHLQRV-----------IDSQAEKLKEL------------DKEIRPFR--QNWEE--- ---------------ADSMKSSVESL-----------QNRVT-ELESVDKSAGQVARNTG LLESQ--------------------------LSRH-----D------------------- ------------------------------------------------------------ ------------QMLSVHDIRLADMDLRFQVLETAS---------------YNGVLIWKI R-DYKRRKQEAVMG-----KT--LSLYSQPFYTGYF-GYKM-------CARVYLN----- --------GDGMGK-GTHLSLFF---VIMR-----------GEYDALL-----P-WPFKQ K---VTLMLMDQGS----SR-RHLGDAFKPDPNSSS-FKKP------------TGEMNIA S-GCPV-------------------FVAQTVLENGT-----YIK---------------- ------------------------------------------- >P_pygmaeus_ENSPPYP00000007003 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MESSKKMDSPGALQTNPPLKLH TDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCRLVLCSPKQ-TECGHRFCESCMAALL -----------SSSSPKCTACQ----------ESIV-KDKVFKDNCCKREILALQIYCRN ---------------ESRGCAEQLTLGHLL--VHL-KNDCHFEELPCVRP-----DCKEK VLRKDLRD----HVEKACK---YREATCSHCKSQVPMIAL-Q--KHEDTDCPCVVVSCPH KCSV--QTLLRSELSAHL-SECVNAPSTCS-FKRYGCVF-Q---GTNQQIKAHEASSAVQ HVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQI-CSFEIEIERQKEMLRNNES KILHLQRV-----------IDSQAEKLKEL------------DKEIRPFR--QNWEE--- ---------------ADSMKSSVESL-----------QNRVT-ELESVDKSAGQVARNTG LLESQ--------------------------LSRH-----D------------------- ------------------------------------------------------------ ------------QMLSVHDIRLADMDLRFQVLETAS---------------YNGVLIWKI R-DYKRRKQEAVMG-----KT--LSLYSQPFYTGYF-GYKM-------CARVYLN----- --------GDGMGK-GTHLSLFF---VIMR-----------GEYDALL-----P-WPFKQ K---VTLMLMDQGS----SR-RHLGDAFKPDPNSSS-FKKP------------TGEMNIA S-GCPV-------------------FVAQTVLENGT-----YIKDDTIFIKVIVDT---- ----------------SDL---------------------PDP >P_troglodytes_ENSPTRP00000011503 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MESSKKMDSPGALQTNPPLKLH TDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQ-TECGHRFCESCMAALL -----------SSSSPKCTACQ----------ESIV-KDKVFKDNCCKREILALQIYCRN ---------------ESRGCAEQLTLGHLL--VHL-KNDCHFEELPCVRP-----DCKEK VLRKDLRD----HVEKACK---YREATCSHCKSQVPMIAL-Q--KHEDTDCPCVVVSCPH KCSV--QTLLRSELSAHL-SECVNAPSTCS-FKRYGCVF-Q---GTNQQIKAHEASSAVQ HVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQI-CSFEIEIERQKEMLRNNES KILHLQRV-----------IDSQAEKLKEL------------DKEIRPFR--QNWEE--- ---------------ADSMKSSVESL-----------QNRVT-ELESVDKSAGQVARNTG LLESQ--------------------------LSRH-----D------------------- ------------------------------------------------------------ ------------QMLSVHDIRLADMDLRFQVLETAS---------------YNGVLIWKI R-DYKRRKQEAVMG-----KT--LSLYSQPFYTGYF-GYKM-------CARVYLN----- --------GDGMGK-GTHLSLFF---VIMR-----------GEYDALL-----P-WPFKQ K---VTLMLMDQGS----SR-RHLGDAFKPDPNSSS-FKKP------------TGEMNIA S-GCPV-------------------FVAQTVLENGT-----YIKDDTIFIKVIVDT---- ----------------SDL---------------------PDP >T_nigroviridis_ENSTNIP00000013509 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MAS QEPSPPSSLEGNKPGFPRKILANNLESKHLCKSCQKVLRRPLQ-AQCGHRFCCFCFRKIV -----------SAGPQTCRACI-SEDLFEEPASILK-SGGAFPDNAARREVEALAAVCPN -----------------EGCTWTGTIKEFE-ARH--EDSCDFMIILCP-------SCKEL MRANEQER----HNERECP---ERTLNCKYCKEAFQLKSI-K--AHDE-ICPKYPMMCEG -CSR--RKIPREKYVDHI-KYCSKFKSPCR-FHVVGCNI-K---VEKEKIHEHERQCSYE HLNLLL--HFIMGIKSS------------------------------------------- --------------------RAKKTKVAEL------------SRRCQELE--VKVST--- ---------------LENIACVLNRE-----------VERSCTTMDAYNRQHRLDQDKIE ILNNK--------------------------VRQL-----E------------------- ------------------------------------------------------------ ------------RTVSLRDLSIVEMDEKMRELSAAT---------------YDGVFVWKI A-DFTKKRQDAVAG-----RA--PAMFSPAFYTSKY-GYKM-------C-RIYLN----- --------GDGTGR-GSHLSLFF---VVMR-----------GHSDALL-----K-WPFNQ K---VTLMLLDQNN-----R-EHIIDAFRPDVSSSS-FQRP------------VSDMNIA S-GCPL-------------------FCPLSKLDCKNS----YIRDDTIFIKVIVDL---- ----------------SGL------------------------ >T_nigroviridis_ENSTNIP00000011878 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M ARISLDCS--PSLPGIPLSVLSVPMENKYKCQQCLQVLRKPVQ-AQCGHRFCVHCFRELT -----------SSGPKPCEACR-QEEIYEEPTSILN-SNEVFPDNAAGREIASLPARCLN -----------------QDCSWTGSIKQYE-AQH--EGRCEFEQIKCD-------ACQAF VLRAEKDR----HNERECE---ARTLNCKYCKFTFHFKDI-K--AHDE-ICSKFPLQCKD -CGK--KKIPREKFNEHI-KSCAKSKSACP-FSEVGCKS-V---VENGKLSEHENSSTME HMRLLL--PIVLSLTQARAEVSDSG-EWQEDSVLGLYRAP-------------------- ------E------------EGVHVGAGAAA------------SVH-VNLE--KKVTA--- ---------------LERIVCVLNRE-----------VERSTAMLEAFAHQHALDQEKIE NLSTK--------------------------LGQL-----E------------------- ------------------------------------------------------------ ------------RVIAMRDLQLSETEQMVRELQSCT---------------YDGIFVWKI S-EFSRRRQEAVAG-----RT--PAMFSPAFYSSKY-GYKM-------CLRLYLN----- --------GDGTGR-GTHLSLFF---VVMK-----------GKCDALL-----K-WPFSQ K---VTLMLLDQNN-----R-EHIIDAFRPDVTSSS-FQRP------------ISEMNIA S-GCPL-------------------FCPLAKLAGKSP----YLKDDTIFIKAIVDL---- ----------------TGL------------------------ >G_aculeatus_ENSGACP00000020860 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MAT QEPSPPSSMESNKPGFPKKILGNQLEDKHLCNCCHNILRRPFQ-AQCGHRFCSYCFNRTV -----------SNGPQKCSACI-KEDLFEDPTSILK-PGCAFPDNAVRREVENLSAVCIH -----------------EHCSWKGSIKDYE-LTH--EGKCEFMIIPCP-------SCKER IRFNEQER----HNERECP---ERTLNCKYCKEPFHFKNI-K--AHDE-ICPKYPMICEG -CAK--KKIPREKYVDHI-KFCSKFRTPCR-FHVVGCDM-S---VEKEKIHDHERAFAYE HLNLLL--HYIMGMKVSMEGLQPQGLELAGHKLLELQQAL-RELEARVSQLST---TSSG P----------------------PVQ-------------------CTELE--VKAGT--- ---------------FENVVCVLNRE-----------VERFATAMEASNRQHKLDQDKIE ALSNK--------------------------VRQL-----E------------------- ------------------------------------------------------------ ------------RTVGLKDLTVAEMEGRLREMSATT---------------FDGVFVWRI S-DFAKKRQDAIAG-----RA--PAMFSPAFYTSKY-GYKM-------CLRIYLN----- --------GDGTGR-GSHLSLFF---VVMR-----------GLSDALL-----K-WPFNQ K---VTLMLLDQSN-----R-EHIIDAFRPDVTSSS-FQRP------------LER---- ----P---------------------CSLC------------------------------ ------------------F------------------------ >O_anatinus_ENSOANP00000023053 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MDSSKKMD-PSLVQQNVPPKGN PDRGPGASIYVPEQGGYKERFVKTVEDKYKCEKCHLILCNPKQ-TECGHRFCETCMNMLL -----------SSSSPKCSACQ----------ENVI-KDKVFKDNCCKREILALQIYCRN ---------------ENRGCTEQLTLGHLL--VHL-KSDCQFEELSCPRA-----DCKEK VLRKDLPD----HIEKSCK---YREATCKYCTSQVPMITL-Q--KHEDTECPCVVVSCPH KCSV--QTLLRSELNAHL-SECINAPSTCS-FKRYGCTF-Q---GTNQQIKAHEASSAVQ HVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQI-CSFEIEIERQKEMLRNNES KILHLQRV-----------IDSQAEKLKEL------------DKEIRPFR--QNWEE--- ---------------ADSMKSSVESL-----------QNRVT-ELESVDKNAGQAARNTG MLETQ--------------------------LSRH-----D------------------- ------------------------------------------------------------ ------------QMLSVHDIRLADMDLRFQVLETAS---------------YNGVLIWKI R-DYKRRKQEAVMG-----KT--LSLYSQPFYTGYF-GYKM-------CARVYLN----- --------GDGMGK-GTHLSLFF---VIMR-----------GEYDALL-----P-WPFKQ K---VTLMLMDQGS----SR-RHLGDAFKPDPNSSS-FKKP------------TGEMNIA S-GCPV-------------------FVAQTVLENGT-----YIKDDTIFIKVIVDT---- ----------------SDL---------------------PDP >H_sapiens_ENSP00000376500 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MESSKKMDSPGALQTNPPLKLH TDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQ-TECGHRFCESCMAALL -----------SSSSPKCTACQ----------ESIV-KDKVFKDNCCKREILALQIYCRN ---------------ESRGCAEQLMLGHLL--VHL-KNDCHFEELPCVRP-----DCKEK VLRKDLRD----HVEKACK---YREATCSHCKSQVPMIAL-Q--KHEDTDCPCVVVSCPH KCSV--QTLLRSELSAHL-SECVNAPSTCS-FKRYGCVF-Q---GTNQQIKAHEASSAVQ HVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQI-CSFEIEIERQKEMLRNNES KILHLQRV-----------IDSQAEKLKEL------------DKEIRPFR--QNWEE--- ---------------ADSMKSSVESL-----------QNRVT-ELESVDKSAGQVARNTG LLESQ--------------------------LSRH-----D------------------- ------------------------------------------------------------ ------------QMLSVHDIRLADMDLRFQVLETAS---------------YNGVLIWKI R-DYKRRKQEAVMG-----KT--LSLYSQPFYTGYF-GYKM-------CARVYLN----- --------GDGMGK-GTHLSLFF---VIMR-----------GEYDALL-----P-WPFKQ K---VTLMLMDQGS----SR-RHLGDAFKPDPNSSS-FKKP------------TGEMNIA S-GCPV-------------------FVAQTVLENGT-----YIKDDTIFIKVIVDT---- ----------------SDL---------------------PDP >D_rerio_ENSDARP00000069217 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MISAAGTLCKWKDM ERPSLPSSLDSTLPGISREVLSVSMEPKYQCQQCKDILRKPFQ-AQCGHRFCVFCFKQLT -----------SSGPIPCEACR-AEGIFEEETSVLN-IAVAFPDNAARREIDSLPAKCPN -----------------EGCSWSGTLKDFE-NQH--EGRCAFERVKCE-------ACQVL ILLSEKDR----HNERECE---ARTLNCKYCKVTFNFKEI-K--AHDE-ICQKFPMQCKD -CGK--KKIPREKFQEHT-KSCAKSKSACQ-FREIGCRA-V---VDNCKQQEHEQTSIME HLRLML--ALLSSM---RLRAEGAG-EWQEDVGLGLYRGP-------------------- ------E------------DAPPAGAHNVG------------RGGGPGVQ--KKVTT--- ---------------LENIVCVLNKE-----------VERSALTMEAISRQHRLDQEKIE NLSNK--------------------------VRQL-----E------------------- ------------------------------------------------------------ ------------RTLTTRDLQLAESEQSLRELQFCT---------------YDGVFIWKI A-EFSRRRQDAVAG-----RA--PAMFSPAFYSSKY-GYKM-------CLRLYLN----- --------GDGTGR-GSHLSLFF---VVMK-----------GKYDALL-----K-WPFSQ K---VTLMLLDQNN-----R-EHIIDAFRPDVSSTS-FQRP------------ISEMNIA S-GCPL-------------------FCPLAKLAGKSS----YLRDDTIFIKAIVDL---- ----------------TGL------------------------ >C_familiaris_ENSCAFP00000026713 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MESSKKMDSPGTLQTNPPLKLH PDRSAGTSIFVPEQGGYKERFVKTVEDKYKCEKCRLVLCNPKQ-TECGHRFCETCMAAVL -----------SSSSPKCTACQ----------ESII-KDKVFKDNCCKREILALQIYCRN ---------------EGGGCTEQLTLGHLL--VHL-KNDCQFEELSCVRA-----DCKEK VLRRDLRD----HVEKACK---YREATCPHCKSQVPMITL-Q--KHEDTECPCVVVSCPH KCSV--QTLLRSELSAHL-SECVNAPSTCS-FKRYGCVF-Q---GTNQQIKAHEASSAVQ HVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQI-CSFEIEIERQKEMLRNNES KILHLQRV-----------IDSQAEKLKEL------------DKEIRPFR--QNWEE--- ---------------ADSMKSSVESL-----------QNRVT-ELESVDKSAGQAARNTG LLESQ--------------------------LSRH-----D------------------- ------------------------------------------------------------ ------------QMLSVHDIRLADMDLRFQVLETAS---------------YNGVLIWKI R-DYKRRKQEAVMG-----KT--LSLYSQPFYTGYF-GYKM-------CARVYLN----- --------GDGMGK-GTHLSLFF---VIMR-----------GEYDALL-----P-WPFKQ K---VTLMLMDQGS----SR-RHLGDAFKPDPNSSS-FKKP------------TGEMNIA S-GCPV-------------------FVAQTVLENGT-----YIKDDTIFIKVIVDT---- ----------------SDL---------------------PDP >E_caballus_ENSECAP00000011833 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MESSKKMDSPGALQTNPPLKLH PDRSTSTAVFVPEQGGYKERFVKTVEDKYKCEKCRLVLCNPKQ-TECGHRFCETCMAALL -----------SSSSPKCTACQ----------EGII-KDKVFKDNCCKREILALQIYCRN ---------------ESRGCVEQLTLGHLL--VHL-KNDCQFEELACVRP-----DCKEK VLRKDLRD----HVEKACK---YREATCSHCKSQVPMITL-Q--KHEDTECPCVVVSCPH KCSV--QTLLRSELSAHL-SECVNAPSTCS-FKRYGCIF-Q---GTNQQIKAHEASSAVQ HVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQI-CSFEIEIERQKEMLRNNES KILHLQRV-----------IDSQAEKLKEL------------DKEIRPFR--QNWEE--- ---------------ADSMKSSVESL-----------QNRVT-ELESVDKSAGQAARNTG LLESQ--------------------------LSRH-----D------------------- ------------------------------------------------------------ ------------QMLSVHDIRLADMDLRFQVLETAS---------------YNGVLIWKI R-DYKRRKQEAVMG-----KT--LSLYSQPFYTGYF-GYKM-------CARVYLN----- --------GDGMGK-GTHLSLFF---VIMR-----------GEYDALL-----P-WPFKQ K---VTLMLMDQGS----SR-RHLGDAFKPDPNSSS-FKKP------------TGEMNIA S-GCPV-------------------FVAQTVLENGT-----YIKDDTIFIKVIVDT---- ----------------SDL---------------------PDP >G_aculeatus_ENSGACP00000006974 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MAA QEQSPPSSLEGNKPGFPKKILANSLEDKHLCNSCQKVLRRPLQ-AQCGHRFCSFCFNKIV -----------SSGPQKCSACI-KEDLFEDPTSILK-QGGAFPDNAARREVEALAAVCPN -----------------EECTWTGTIKEFE-ASH--EDNCDFMIIMCP-------SCKEL MRANEQER----HNERECP---ERTLNCRYCKEPFLLKNI-K--AHDE-ICPKYPMICEG -CAK--KKIPREKYVDHI-KFCSKCKAPCR-FHVVGCDA-SVMEVENEKLHDHERQCSYE HLNLLL--HFIMGIKLQ------------------------------------------- -------------------LQSEKAKVAEL------------SRRCQELE--LKVGT--- ---------------FENIACVLNRE-----------MERSCSTMEAYNRQHRLDQDKIE ILNNK--------------------------VRQL-----E------------------- ------------------------------------------------------------ ------------RTVSLRDLSIVEMEGKMRDMSAAT---------------YDGIFVWKI S-DFTKKRQDAVAG-----RA--PAMFSPAFYTSKY-GYKM-------CLRIYLN----- --------GDGTGR-GTHLSLFF---VVMR-----------GHSDALL-----K-WPFNQ K---VTLMLLDQNS-----R-EHIIDAFRPDVSSSS-FQRP------------VSDMNIA S-GCPL-------------------FCPLPKLDSKNS----YIRDDTIFIKAIVDL---- ----------------TGL------------------------ >M_domestica_ENSMODP00000016701 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MDSSKKMD-PPNPLQTVQQKAN PDRGAAVSIYVPEQGGYKEKFVKPVEDKYKCEKCHLILCNPKQ-TECGHRFCETCMHVLL -----------SAPSPKCTACQ----------ENII-KDKVFKDNCCKREILALQIYCRN ---------------ESRGCTEQLTLGHLL--VHL-KSECQFEELPCVRA-----DCKEK ILRKDLQD----HVEKSCK---YREATCQYCKSQVPMITL-Q--KHEDTECPCVVVSCPH KCSV--QTLLRSELNAHL-SECINAPSTCS-FKRYGCTF-Q---GTNQQIKTHEASSAVQ HVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQI-CSFEIEIERQKEMLRNNES KILHLQRV-----------IDSQAEKLKEL------------DKEIRPFR--QNWEE--- ---------------ADSMKSSVESL-----------QNRVT-ELESVDKSAGQAARNTG LLETQ--------------------------LSRH-----D------------------- ------------------------------------------------------------ ------------QMLSVHDIRLADMDLRFQVLETAS---------------YNGVLIWKI R-DYKRRKQEAVMG-----KT--LSLYSQPFYTGYF-GYKM-------CARVYLN----- --------GDGMGK-GTHLSLFF---VIMR-----------GEYDALL-----P-WPFKQ K---VTLMLMDQGS----SR-RHLGDAFKPDPNSSS-FKKP------------TGEMNIA S-GCPV-------------------FVAQTVLENGT-----YIKDDTIFIKVIVDT---- ----------------SDL---------------------PDP >T_rubripes_ENSTRUP00000011363 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S QEPSPPSSLEGNKPGFPKKILANNLENKHLCKSCQKVLRRPLQ-AQCGHRFCSFCFHKIV -----------SAGPQTCSACI-SEDLFEEPASILK-LGGAFPDNAARREVEALAAVCPN -----------------EGCIWTGTIKEFE-ARH--EDSCDFMIILCP-------SCKEL MRVNEQER----HNERECP---ERTLNCKYCKDPFQLKNI-K--AHDE-ICPKYPMICEG -CSK--KKIPREKYVDHI-KYCSKFKSPCR-FHVVGCNT-S---VEKEKIHDHERQCSYE HLNLLL--HFIMGIKISLESLPPQSLDVASHKLLELHQSL-RDLELK------------- -------------------LQSEKTKVAEL------------SRRCQDLE--LKVRT--- ---------------FENIVCVLNRE-----------VERSCTTMEAYNRQHRLDQDKIE ILNNK--------------------------VRQL-----E------------------- ------------------------------------------------------------ ------------RTVSLRDLSIVEIDEKMRELSAAT---------------YDGVFVWKI S-DFTKKRQDAVAG-----RA--PAMFSSAFYTSKY-GYKM-------CLRIYLN----- --------GDGTGR-GTHLSLFF---VVMR-----------GHSDALL-----K-WPFNQ K---VTLMLLDQNN-----R-EHIIDAFRPDISSSS-FQRP------------VSDMNIA S-GCPL-------------------FCPLPKLDCKNS----YIRDDTIFIKVIVDL---- ----------------TGL------------------------ >B_taurus_ENSBTAP00000017918 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MEPSKKLDAAGALPANPPLKLH PERGAGPAVLVPEQGGYKERFVKAVEDKYKCEKCRLVLCSPKQ-TECGHRFCETCMGALL -----------SSSSPKCTACQ----------EVII-KDKVFKDNCCKREILALQIFCRN ---------------EGRGCTEQLALGHLL--VHL-KNDCQFEELPCVRA-----DCKEK VLRKDLRD----HVEKACK---YREATCSHCKSQVPMVTL-Q--KHEDTECPCVAVSCPH KCSV--QTLLRSELSAHL-SECVNAPSTCS-FKRYGCVF-Q---GTNQQIKAHEASSAVQ HVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQI-CSFEIEIERQKEMLRNNES KILHLQRV-----------IDSQAEKLKEL------------DKEIRPFR--QNWEE--- ---------------ADSMKSSVESL-----------QNRVT-ELESVDKSAGQAARNTG LLESQ--------------------------LSRH-----D------------------- ------------------------------------------------------------ ------------QMLSVHDIRLADMDLRFQVLETAS---------------YNGVLIWKI R-DYKRRKQEAVMG-----KT--LSLYSQPFYTGYF-GYKM-------CARVYLN----- --------GDGMGK-GTHLSLFF---VIMR-----------GEYDALL-----P-WPFKQ K---VTLMLMDQGS----SR-RHLGDAFKPDPNSSS-FKKP------------TGEMNIA S-GCPV-------------------FVAQTVLENGT-----YIKDDTIFIKVIVDT---- ----------------SDL---------------------PDP >G_gorilla_ENSGGOP00000016344 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MPGFDYKFLEKPKRRLLCPLCGKPMREPVXXPPCGHRFCDTCLQEFL -----------SEGVFKCPEDQ----------LPLD-YAKXXXXXXXXXXXXXXXXXXXX ---------------XXXXXXXXXXXXXXX--XX--XXXXXXXXXXXXX------RCPMK LSRRDLPA----HLQHDCP---KRRLKCEFCGCDFSGEAY-E--SHEG-MCPQESVYCEN KCG---ARMMRRLLAQHATSECPKRTQPCT-Y----CTK-E---FVFDTIQSHQYQCPRL PVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGC-------------------- ------------------------------------------KHRCPKLAMARHVEE--- ------------------------------------------------------------ SVKPH--------------------------LAMM-----C------------------- ------------------------------------------------------------ ------------ALVSRQRQELQELRRELEELSVG----------------SDGVLIWKI G-SYGRRLQEAKAK-----PN--LECFSPAFYTHKY-GYKL-------QVSAFLN----- --------GNGSGE-GTHLSLYI---RVLP-----------GAFDNLL-----E-WPFAR R---VTFSLLDQSDPGLAKP-QHVTETFHPDPNWKN-FQKP-----GTWRGS-LDESSLG F-GYPK-------------------FISHQDIRKR---N--YVRDDAVFIRAAVELPRKI LS----------------------------------------- >M_domestica_ENSMODP00000024498 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------LTDTAP VGPHLIPDENEFPFGYPASICQGTPEPKYLCCGCHNVLKKAQQ-TLCGHRYCAACLSWIL -----------SSPND----------------GTLF-FWGFFQNS--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------LVPAEDQDRCP-FADIGCSF-K---GGQERVKEHEASSLSD HLRRLL--ELVIRTKVQAGPSRGRGASGRRQAAEPEPKAP----ERNLSDLQLQGAVEVN GDLEADYFHAASSDSEEELALQRFMK----------------EKLLSELE--EKLRV--- ---------------FENIVTVLNKE-----------VEASHLAIAASVHQSGLTQDLIL SLEQR--------------------------VVDL-----Q------------------- ------------------------------------------------------------ ------------QTLTQKDLALTKLEQTLHLLEEAS---------------YDGVYLWKI T-NFTRRCHESACG-----RT--VSLFSPAFYTARY-GYKL-------CLRIYLN----- --------GDGMGK-GTHLSLFI---VVMK-----------GKYDALL-----E-WPFRN KAIPVTFMLLDQNN-----R-EHVTDSFHPDLTSGS-FQKP------------QGESNIA S-GRPM-------------------FFPLNKLQSSKH-A--YVKDDTLFLKCVIET---- ----------------NS------------------------- >A_carolinensis_ENSACAP00000000193 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MDTSKKTD-PPVSVETVQQKAN VERSPVPSVYIPEQGGYKEKFVNAVEDKYKCEKCRLILCNPRQ-TECGHRYCETCMNALL -----------SCTIPKCTACQ----------ETIV-KEKIFKDNCCRRELLALQIFCRN ---------------ENKGCREQLTLGQLL--THL-RNDCLFEELPCPRV-----DCKEK ILRKDLPD----HAEKTCK---YRETTCKYCKSQVPIIMI-Q--KHEDADCPCVMVTCPH KCSV--SALLRKELNAHL-SECINAPSTCS-FKRYGCTF-Q---GTNQQVKAHETSSAVQ HVDLLK--EWSNCLENKVAMLQNES-LEKNKSIQTLHNQI-CSFEIEIERQKEMLRSNES KIHHLQRV-----------IDSQAEKLKEL------------DKEIRPFR--QNWEE--- ---------------ADSMKSSVESL-----------QNRVT-ELESVDKTAGQGARNAG LLESQ--------------------------LSRH-----D------------------- ------------------------------------------------------------ ------------QMLSVHDIRLADMDLRFQVLETAS---------------YNGILIWKI R-DYKRRKQEAVMG-----KT--LSLYSQPFYTGYF-GYKM-------CARVYLN----- --------GDGMGK-GTHLSLFF---VIMR-----------GEYDALL-----P-WPFKQ K---VTLMLMDQGP----SR-RHLGDAFKPDPNSSS-FKKP------------TGEMNIA S-GCPV-------------------FVAQTVLENGT-----YIKDDTIFIKVIVDT---- ----------------SDL---------------------PDP >O_latipes_ENSORLP00000008989 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M ARISWDSL--SSLPGIPLSVLSVPMEDKYKCQQCLQVLRKPVQ-AQCGHRFCVHCFRQLT -----------SSGPKPCQACR-KEEIYEEPMSILN-SSEAFPDNAAGREIASLPARCLN -----------------QGCDWTGSIKEYE-AKH--EGRCEFEQIQCE-------ACQAL VLRKDKDR----HNDRECE---ERTLNCKYCKVTFNFKDI-K--AHDE-ICQKFPLQCKD -CGK--KKIPREKFNDHA-KSCAKSKSACP-FSEVGCKS-V---VENGKISEHEHSSTME HLRLLL--PMVLSMTRTRLDTSPSG-EWQEDSGLGLYRAP-------------------- ------D------------D----GCGAAA------------SVPSVDLD--KKVSA--- ---------------LENIVCVLNRE-----------VERSSLTLEAFSHQHRLDQEKIE NLSNK--------------------------IRQL-----E------------------- ------------------------------------------------------------ ------------RSLTVKDLQLSEAEQMVRELQYCT---------------YDGIFVWKI T-DFSHRRQEAVSG-----RA--PAMFSPAFYSSKY-GYKM-------CLRLYLN----- --------GDGTGR-GTHLSLFF---VVMR-----------SKYDALL-----K-WPFSQ K---RTIWAASKPN-----REEHIIDAFRPDITSTS-FQRP------------VSEMNIA S-GCPL-------------------FCPLAKLAGKSP----YLRDDTIFIKAIVDL---- ----------------SGL------------------------ >C_familiaris_ENSCAFP00000001637 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LGAQAGRGRVSPDPSGST GLQRAPILTGPPRAGGEVHLPLAPCGLTGHVRGPLVLAVAEPRVEPRGVRGAPGARVLRP PLPPGSGPAGTRAQAMAAPDLSTNLQEEATCAICLDYFTDPVM-TDCGHNFCRECIRRCW GQP---------EGPYACPECR----------ELSP-QRNLRPNRPLAKMAE-------- ------------------------MARRLH-------PPSPVPQGVCA-------AHREP LAAFCGDE---------------LRLLCAACERSGEHWTH-R-------VRPLQDAAEDL -------KGKLEKSLEHLRKQMEDALLFQA-QAEETCALWQ-------KMVESQRQNVLA EFE-----RLRRLLAEEEQRLLQRLEEEELEVLPPLRDSA-------------------- --------------------TRLGQQSAQL------------AELIAELEGRCQLPALGL LQD------------IRDTLRRVQDV-------KLQLPEVVPMEM-KTVCRVPGLVEALR RFREHSEVQGQAVRSSVGHSRLTGDVTLDPDTANP-----E------------------- ------------------------------------------------------------ ------------LVLSEDRRSVRRGDLR-QALPDSPERFDPGPCVLGREPLTSGRHYWEV --EVGERASWALGV-----CREDANRKEKGELFAGN-GFWI---------LVFLG----- --------SYYNSSERAFAPL-----RDPP-----------QRVGIFL-----D---YEA G----HLSFYSASD-----G-SLLYAFPETP------FSGT------------------- -------------------------LRALFSPLSSSPTPMTICR-----LKGGPG----- ------------------------------------------- >T_rubripes_ENSTRUP00000047803 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M ARISMDCS--SSLPGIPLSVLSVPMENKYKCQQCLQVLRKPVQ-AQCGHRFCIHCFKELT -----------SSGPKPCEACR-QEEIYEEPISVLN-SNEVFPDNAAGREIASLPARCLN -----------------QGCSWTGSIKQYE-AQH--EGRCELEQIKCD-------ACQAS VLRAEIDR----HNERECE---ARTLNCKYCKLTFHFKDI-K--AHDD-ICLKFPLPCKD -CGK--KKIPREKFNEHI-RSCAKSKSACP-FSEVGCKS-V---VDNGKLREHEHSSTVE HLHLLL--PMVLSLTRTRAEVSESG-EWQEDSGLGLYRAP-------------------- ------E------------EGVNVGAGAAA------------SVHAVDLE--KKVTA--- ---------------LENIICVLNRE-----------VERSALKVEAFAHQHCLDQEKIE NLVSK--------------------------VGQL-----E------------------- ------------------------------------------------------------ ------------RAIAMRDLQLSETEQMVRELQSCT---------------YDGIFVWKI S-EFSRRRQEAVAV-----RM--PTMFSPAFYSSKY-GYKM-------CLRLYLN----- --------GDGTGR-GTHLSLFF---VVMR-----------GKCDALL-----K-WPFSQ K---VTLMLLDQNN-----R-EHIIDAFRPDVTSSS-FQRP------------ISEMNIA S-GCPL-------------------FCPLAKLAGKSP----YLKDDTIFIKAIVDL---- ----------------TGL------------------------ >O_anatinus_ENSOANP00000001757 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------AFSDAAINKEISELNVHCVT -----------------PGCSWTGLMKNFEPQDH--QAECDCALIPCHA------GCGLM IMRKKLPD----HLENGCA---KSPTTCLKCKQTFCSMEY-Q------------------ -------------FNSPG-STASRIQDGCP-FSVIGCSFMH---GSREKVKEHETSSMDM HLGLLL--QAVSQTKANQGDCEEEL----------------------------------- -------------------ALQRFMR----------------EKLISDLE--EKLHV--- ---------------FENIVAVLNKE-----------VESSNMAIAASIHQSNLDRDMIL RLEQR--------------------------VLDL-----H------------------- ------------------------------------------------------------ ------------QTLAQKDLALARLKQSLQFSELAS---------------YDGIYLWKI T-DFSRKCHESLCG-----RT--TSLFSPVFYTARY-GYKV-------CLRVYLN----- --------GDGTGK-GTHISLFF---VIMK-----------GEYDSLL-----Q-WPFRN K---VTFMLLDQNN-----R-EHVIDAFRPDLNSAS-FQKP------------QGEMNVA S-GCPM-------------------FFPLNKLQSPKH-A--YVKDDTLFLKCIIET---- ----------------NS------------------------- >C_intestinalis_ENSCINP00000003143 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------MAPE NLSQM--------------------------VDAF-----E------------------- ------------------------------------------------------------ ------------RQLGMYDVRIADMDQRFQVIETTS---------------YSGVVIWKI R-DFSRRKREAVSG-----RT--LSLYSQPFYTSRY-GYKM-------CARVYLN----- --------GDGMGK-GTHMSLFF---VVMK-----------GEYDALL-----P-WPFRQ K---VTLMLLDQGM----DR-RHLSDTFRPDPTSSS-FKKP------------TSDMNIA S-GCPL-------------------FVAHNVIEDSS-----YVKEDTIFLRIHVDT---- ----------------SDL---------------------ENF >C_intestinalis_ENSCINP00000027890 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------M--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------LSTENVS-PSLQRS S--------V---FNSWT-SKSPIDFSISE-PSFNFNGL-S---HPEVGISDYCKSEHDA LRSHLA--EISQTL-------------NNLKNSNDVSPEI-RKLEVRLKAIQRMTAQQTD RSLALKKEVGDNDAANKRANTDLTQKVEEI------------AREIAQIK--EKQNE--- ---------------LER-------------------------NIESTSGSR--EQMAPE NLSQM--------------------------VDAF-----E------------------- ------------------------------------------------------------ ------------RQLGMYDVRIADMDQRFQVIETTS---------------YSGVVIWKI R-DFSRRKREAVSG-----RT--LSLYSQPFYTSRY-GYKM-------CARVYLN----- --------GDGMGK-GTHMSLFF---VVMK-----------GEYDALL-----P-WPFRQ K---VTLMLLDQGM----DR-RHLSDTFRPDPTSSS-FKKP------------TSDMNIA S-GCPL-------------------FVAHNVIEDSS-----YVKEDTIFLRIHVDT---- ----------------SDL---------------------ENF >X_tropicalis_ENSXETP00000056667 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------SEGVFKCPEDQ----------LPLD-YAKIYPDRDLETQVMGLSIRCIH ---------------SEEGCRWSGQLKQLQ--PH--LNICAFNVIPCPN------RCSTK LIRRDLPE----HMQHDCP---KRKVRCEFCGADFTGEAY-E--DHQG-CCPQESVYCEN KCG---ARMMRRVLSQHSLVECPKRTQPCP-Y----CNK-E---FVFDTIQSHQYQCPRY PTPCPNQCGIASIAREDLSNHLKDSCSSALVLCPFKDSGC-------------------- ------------------------------------------KHRGPKITISRHLEE--- ------------------------------------------------------------ NMRAH--------------------------LSMM-----S------------------- ------------------------------------------------------------ ------------SLVSRQRQEILELRKQVEELSVS----------------SEGVLIWKI S-DYSRKVQEAKVR-----GN--FESFSPPFYTHKY-GYKL-------QVSAFLN----- --------GNGSGE-GSYLSVYI---RVLP-----------GEYDNLL-----E-WPFSY R---VTFSLLDQSDPSLSKP-QHITETFNPDPNWKN-FQKP-----TGSRNS-LDESTLG F-GYPK-------------------FISHEDIRKR---N--YVRDNAIFLRASVEIPQKI IA----------------------------------------- >E_caballus_ENSECAP00000009502 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------SEGVFKCPEDQ----------LPLD-YAKIYPDPELEVQVLGLPIRCIH ---------------SEEGCRWSGPLRHLQ--GH--LNTCSFNVVPCPN------RCPTK LSRRDLPA----HLQHDCP---KRRLKCEFCGCDFSGEAF-E--SHEG-MCPQESVYCEN KCG---ARMMRRLLAQHATSECPKRTQPCT-Y----CAK-E---FVFDTIQSHQYQCPRL PVPCPNQCGVGTVAREDLPGHLKDSCSTALVLCPFKDSGC-------------------- ------------------------------------------KHRCPKLAMARHVEE--- ------------------------------------------------------------ SVKPH--------------------------LAMM-----C------------------- ------------------------------------------------------------ ------------ALVSRQRQELQELRRELEELSVG----------------SDGVLIWKI G-SYGRRLQEAKAK-----PN--LECFSPAFYTHKY-GYKL-------QVSAFLN----- --------GNGSGE-GTHLSLYI---RVLP-----------GAFDNLL-----E-WPFAR R---VTFSLLDQSDPGLAKP-QHVTETFHPDPNWKN-FQKP-----GTWRGS-LDESSLG F-GYPK-------------------FISHQDIRKR---N--YVRDDAVFIRASVELPRKI LS----------------------------------------- >B_taurus_ENSBTAP00000016271 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------QIYPDPELEVQVLGLSIRCIH ---------------SEEGCRWNGPLRHLQ--GH--LNTCSFNVVPCPN------RCPAK LSRRDLPA----HLQHDCP---KRRLKCEFCGCDFSGEAF-E--SHEG-VCPQESVYCEN KCG---ARMMRRLLAQHATSECPKRTQPCT-Y----CTK-E---FVFDTIQSHQYQCPRL PVPCPNQCGVGTVAREDLPGHLKDSCSTALVLCPFKDSGC-------------------- ------------------------------------------KHRCPKLAMARHVEE--- ------------------------------------------------------------ SVKPH--------------------------LAMM-----C------------------- ------------------------------------------------------------ ------------ALVSRQRQELQELRRELEELSVG----------------SDGVLIWKI G-SYGRRLQEAKAK-----PN--LECFSPAFYTHKY-GYKL-------QVSAFLN----- --------GNGSGE-GTHLSLYI---RVLP-----------GAFDNLL-----E-WPFAR R---VTFSLLDQSDPGLAKP-QHVTETFHPDPNWKN-FQKP-----GTWRGS-LDESSLG F-GYPK-------------------FISHQDIRKR---N--YVRDDAVFIRASVELPRKI LS----------------------------------------- >T_nigroviridis_ENSTNIP00000019321 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------VK LTRRDLPD----HLQHDCP---KRKVKCEFCGSEFTGEAY-E--NHQG-VCPQESVYCEN KCG---ARMMRRLLSQHGMAECPKRTQPCK-Y----CGK-E---FVFDTIQNHQYHCPRF PVQCPNQCGTPNIAREDLANHVKDNCGSALVLCPFKDAGC-------------------- ------------------------------------------KHRCPKLAIGRHLED--- ------------------------------------------------------------ TTKSH--------------------------LTMM-----C------------------- ------------------------------------------------------------ ------------NLVGRQRQEILELRREMEELSVS----------------HDGILIWKL N-DYSRKLQEAKIR-----SN--HEFFSPPFYTHRY-GYKL-------QVSAFLN----- --------GNGSGE-GSHLSVYI---RVLP-----------GEYDNLL-----E-WPFSY K---VTFSLLDQSDPSLSKP-QHITETFNPDPNWKN-FQKP-----NSTRNS-LDESTLG F-GYPK-------------------FISHEEIKKR---N--YIRDNCIFIKASIEIPQKI MA----------------------------------------- >P_troglodytes_ENSPTRP00000015252 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------L -----------SEGVFKCPEDQ----------LPLD-YAKIYPDPELEVQVLGLPIRCIH ---------------SEEGCRWSGPLRHLQ--GH--LNTCSFNVIPCPN------RCPMK LSRRDLPA----HLQHDCP---KRRLKCEFCGCDFSGEAY-E--SHEG-MCPQESVYCEN KCG---ARMMRRLLAQHATSECPKRTQPCT-Y----CTK-E---FVFDTIQSHQYQCPRL PVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGC-------------------- ------------------------------------------KHRCPKLAMARHVEE--- ------------------------------------------------------------ SVKPH--------------------------LAMM-----C------------------- ------------------------------------------------------------ ------------ALVSRQRQELQELRRELEELSVG----------------SDGVLIWKI G-SYGRRLQEAKAK-----PN--LECFSPAFYTHKY-GYKL-------QVSAFLN----- --------GNGSGE-GTHLSLYI---RVLP-----------GAFDNLL-----E-WPFAR R---VTFSLLDQSDPGLAKP-QHVTETFHPDPNWKN-FQKP-----GTWRGS-LDESSLG F-GYPK-------------------FISHQDIRKR---N--YVRDDAVFIRAAVELPRKI LS----------------------------------------- >O_cuniculus_ENSOCUP00000000748 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MPGFDYKFLEKPKRRLLCPLCGKPMREPVKVSTCGHRFCDTC-QSFL -----------XXXXXXXXXXX----------XXXX-XXXIYPDPELEVQVLGLPIRCIH ---------------SEEGCRWSGPLRHLQ--GH--LNTCSFNVVACPN------RCPAK LSRRDLPA----HLQHDCP---KRRLKCEFCGCDFSGEAY-E--SHEG-MCPQESVYCEN KCG---SRMMRRLLAQHATSECPKRTQPCT-Y----CTK-E---FVFDTIQSHQYQCPRL PVPCPNQCGVGTVAREDLPGHLKDSCSTALVLCPFKDSGC-------------------- ------------------------------------------KHRCPKLAMARHVEE--- ------------------------------------------------------------ SVKPH--------------------------LAMM-----C------------------- ------------------------------------------------------------ ------------ALVSRQRQELQELRRELEELSVG----------------SDGVLIWKI G-SYGRRLQEAKAK-----PN--LECFSPAFYTHKY-GYKL-------QVSAFLN----- --------GNGSGE-GTHLSLYI---RVLP-----------GAFDNLL-----E-WPFAR R---VTFSLLDQSDSGWARP-QHVTETFHADSNWEEAFQKP-----GTWRGS-LDESSLG F----------------------------------------------------------- ------------------------------------------- >P_pygmaeus_ENSPPYP00000009119 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------EGVFKCPEDQ----------LPLD-YAKIYPDPELEVQVLGLPIRCIH ---------------SEEGCRWSGPLRHLQ--GH--LNTCSFNVIPCPN------RCPMK LSRRDLPA----HLQHDCP---KRRLKCEFCGCDFSGEAY-E--SHEG-MCPQESVYCEN KCG---ARMMRRLLAQHATSECPKRTQPCT-Y----CSK-E---FVFDTIQSHQYQCPRL PVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGC-------------------- ------------------------------------------KHRCPKLAMARHVEE--- ------------------------------------------------------------ SVKPH--------------------------LAMM-----C------------------- ------------------------------------------------------------ ------------ALVSRQRQELQELRRELEELSVG----------------SDGVLIWKI G-SYGRRLQEAKAK-----PN--LECFSPAFYTHKY-GYKL-------QVSAFLN----- --------GNGSGE-GTHLSLYI---RVLP-----------GAFDNLL-----E-WPFAR R---VTFSLLDQSDPGLAKP-QHVTETFHPDPNWKN-FQKP-----GTWRGS-LDESSLG F-GYPK-------------------FISHQDIRKR---N--YVRDDAVFIRAAVELPRKI LS----------------------------------------- >C_intestinalis_ENSCINP00000005981 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------M--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------IPELNQKLKEM------------IEEMTRIR--QKQNE--- ---------------LER-------------------------KL----STR--NQENEQ NFLAQ--------------------------INGF-----E------------------- ------------------------------------------------------------ ------------QQIGLYDVRIADMDQRFQVLETTS---------------YSGVALWKI N-NFQPRKREAESG-----RA--LSIYSQPFYTSRY-GYKM-------CARVYLN----- --------GDGMGK-GTHVSLFF---VLMK-----------GEYDNLL-----P-WPFRQ K---VTLMLLDQGL----ER-RHLSDMFRPDPTSSS-FTKP------------TSDMNIA S-GCPL-------------------FVAHNLIEGSS-----YVKDDVIFIRIHVDT---- ----------------TDL---------------------ETF >M_mulatta_ENSMMUP00000028200 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------SEGVFKCPEDQ----------LPLD-YAKIYPDPELEVQVLGLPIRCIH ---------------SEEGCRWNGPLRHLQ--GH--LNTCSFNVVPCPN------RCPMK LSRRDLPA----HLQHDCP---KRRLKCEFCGCDFSGEAY-E--SHEG-MCPQESVYCEN KCG---ARMMRRLLAQHATSECPKRTQPCT-Y----CTK-E---FVFDTIQSHQYQCPRL PVPCPNQCGVGTVAREDLPGHLKDSCSTALVLCPFKDSGC-------------------- ------------------------------------------KHRCPKLAMARHVEE--- ------------------------------------------------------------ SVKPH--------------------------LAMM-----C------------------- ------------------------------------------------------------ ------------ALVSRQRQELQELRRELEELSVG----------------SDGVLIWKI G-SYGRRLQEAKAK-----PN--LECFSPAFYTHKY-GYKL-------QVSAFLN----- --------GNGSGE-GTHLSLYI---RVLP-----------GAFDNLL-----E-WPFAR R---VTFSLLDQSDPGLAKP-QHVTETFHPDPNWKN-FQKP-----GTWRGS-LDESSLG F-GYPK-------------------FISHQDIRKR---N--YVRDDAVFIRAAVELPRKI LS----------------------------------------- >H_sapiens_ENSP00000377086 MSPEPVPPPPPPQCPGCDRAEPIAQRLEEGDEAFRAGDYEMAAELFRSMLAGLAQPDRGL CLRLGDALARAGRLPEALGAFRGAARLGALRPEELEELAGGLVRAVGLRDRPLSAENPGG EPEAPGEGGPAPEPRAPRDLLGCPRCRRLLHKPVTLPCGLTVCKRCVEPGPARPQVRRVN VVLSGLLEKCFPAECRLRRLAGQARSLQRQQQPEAALLRCDQALELAPDDNSLLLLRAEL YLTMKNYEQALQDASAACQNEPLLIKGHQVKAQALSGLGRSKEVLKEFLYCLALNPECNS VKKEAQKVMCEVLFSATANVHENLTSSIQSRLKAQGHSHMNAQALLEEGDAGSSENSSEK SDMLGNTNSSVLYFILGLHFEEDKKALESILPTAPSAGLKRQFPDDVEDAPDLNAPGKIP K--KDLSLQRSPNSETEESQGLSLDVTDFECALCMRLLFEPVT-TPCGHTFCLKCLERCL ------------DHAPHCPLCK----------DKLS-ELLASRNFNITVLAEELIFRYLP ---------DELSDRKRIYDEEMSELSNLTRDVPIFVCAMAFPTVPCPL----------- ------------HVFEP-----RYRLMIRRCMETGTKRFG-------------------- --------------------MCLSAEHAG--LSEYGCMLEI---KDVRTFPDGSSVVDAI GIS--------------------------------------------------------- ------------------------------------------------------------ ------------------RFRVLSHR-----------------------HRDGYNTADIE YLEDE------------------------------------------------------- ------------------------------------------------------------ ------------KVEGPEYEELAALHDSVHQQSVS----------------------WFA --SLQDRMKEQILS-----HFGVMPDREPEPQSNPS------------------------ ---------------GPAWSWWI------------------------L-----AVLPLER K---AQLAILGMTS-----------------------LKER------------------- -------------------------LL--------------AIRRILVIITRKMNSRQEL ANARERNN----------------------------------- >M_mulatta_ENSMMUP00000022977 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---MKNYEQAFQDASAVCQNEPLLIKGHQVKAQALSGLGRSKEVLKQFLYCLALNPECNS MKKEAQKVMCEVLFSATENVHENLTSSIQSRLKAQGHSHMNAQALLEERDAGSSENSSEK SDMLGNTNSSVLYFILGLHFEEDKKALESILPTAPSAGLKRQFPDDVEDAPDLNAPGKIP K--KDLSPQRSPNSETEESQGLSLDVTDFECALCMRLLFEPVT-TPCGHTFCLKCLERCL ------------DHAPHCPLCK----------DKLS-ELLASRNFNITVLAEELIFRYLP ---------DELSDRKRIYDEEMSELSNLTRDVPIFVCAMAFPTVPCPL----------- ------------HVFEP-----RYRLMIRRCMETGTKRFG-------------------- --------------------MCLSAEHAG--LSEYGCMLEI---KDVKTFPDGSSVVDAI GVS--------------------------------------------------------- ------------------------------------------------------------ ------------------RFRVLSHR-----------------------HRDGYNTADIE YLEDE------------------------------------------------------- ------------------------------------------------------------ ------------KVEGPAYEELAALHDSVHQQSVS----------------------WFA --SLQDRMKEQILS-----HFGVMPDREPEPQSNPS------------------------ ---------------GPAWSWWI------------------------L-----AVLPLER K---AQLAILGMTS-----------------------LKER------------------- -------------------------LL--------------AIRRILVIITRKMNSRQEL ANARERNN----------------------------------- >M_domestica_ENSMODP00000013602 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MGSALSS DSGRAAPASRATPSSLPRRSEVELPITSFDCSVCLEVLHQPLR-TRCGHVFCRSCISTSL -----------RNSKWTCPYCR----------AYLP--SEGVPATDIMKKMKAVYQNCTE -------------------CNTQVCLSEMR--AH--IRTC-----------------QKY IEKYGPLQ----ELREITSCIFYSRCSCPFCERELD-----E------------------ ------DSLLNHCLTYHR---SERRPVFCPLCHFIPNGESR---NSSDSLIRH------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------LQIRHTMFY---------------------------- ---------------DEFIDFNVIEEALIR-----------RVLDRSL------------ ------LEYMNHSNST-------------------------------------------- ------------------------------------------------------------ ------------------------------------------- >M_musculus_ENSMUSP00000109336 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -M-AETSLLEAGTSAASTAAALENLQVEASCSVCLEYLKEPVI-IECGHNFCKACITRWW EDL---------ERDFPCPVCR----------KTSR-YRSLRPNRQLGSMVE-------- ------------------------IAKQLQ---T--VKRKIRDESLCS-------QHHEP LSLFCYED---------------QEAVCLICAISHTHRPH-T-------VVPMDDATQEY -------KEKLQKCLEPLEQKLQEITCCKA-SEEKKPGELK-------RLVESRRQQILK EFE-----ELHRRLDEEQQTLLSRLEEEEQDILQRLRENA-------------------- --------------------AHLGDRRRDL------------AHLAAEVEGKCLQSGFEM LKD------------VKSTLEKCEKV-------KTMEVTSVSIELEKNFSNFPRQYFALR KILKQLI--------A--------DVTLDPETAHP-----N------------------- ------------------------------------------------------------ ------------LVLSEDRKSVKFVETRLRDLPDTPQRFTFYPCVLATEGFTSGRHYWEV --EVGDKTHWAVGV-----CRDSVSRKGELTPLPET-GYWR--------VRLWNG----- --------DKYAATTTPFTPLHI---KVKP-----------KRVGIFL-----D---YEA G----TLSFYNVTD-----R-SHIYTFTDT-------FTEK------------------- --LWPL-------------------FYPGIRAGRKNAAP--------LTIRPPTDWE--- ------------------------------------------- >C_intestinalis_ENSCINP00000001432 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------M--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------YSHKI LQRQLQ--EMKNAVE-----LEMRK-RESDRDGNVLRANI-TKLEQRLTALQRMTAQQTD RSLALKKEVGDNDAANKRANTELTQKVEEI------------GREIAQIK--EKQNE--- ---------------LKR-------------------------KLESTSSSR--EQIAPE NLSQM--------------------------VDAF-----E------------------- ------------------------------------------------------------ ------------LQLGMYDVRIADMDQRFQVIETTS---------------YSGFLIWKI R-DFSRRKREAVSG-----RT--LSLYSQPFYTSRY-GYKM-------CARVYLN----- --------GDGMGK-GTHMSLFF---VVMK-----------GEYDALL-----P-WPFRQ K---VTLMLLDQGM----DR-RHLSDTFRPDPTSSS-FKKP------------TSDMNIA S-GCPL-------------------FVAHNVIEDSS-----YVKEDTIFLRIHVDT---- ----------------SDL---------------------ENF >P_troglodytes_ENSPTRP00000055419 ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVN VVLSVLLEKCFPAECRLRRLAGQARSLQRQQQPEAALLRCDQALELAPDDNSLLLLRAEL YLTMKNYEQALQDASAACQNEPLLIKGHQVKAQALSGLGRSKEVLKEFLYCLALNPECNS VKKEAQKVMCEVLFSATANVHENLTSSIQSRLKAQGHSHMNAQALLEEGDAGSSENSSEK SDTLGNTNSSVLYFILGLHFEEDKKALESILPTAPSAGLKRQFPDDVEDAPDLNAPGKIP K--KDLSPQRSPNSETEESQGLSLDVTDFECALCMRLLFEPVT-TPCGHTFCLKCLERCL ------------DHAPHCPLCK----------DKLS-ELLASRNFNITVLAEELIFRYLP ---------DELSDRKRIYDEEMSELSNLTRDVPIFVCAMAFPTVPCPL----------- ------------HVFEP-----RYRLMIRRCMETGTKRFG-------------------- --------------------MCLSAEHAG--LSEYGCMLEI---KDVRTFPDGSSVVDAI GIS--------------------------------------------------------- ------------------------------------------------------------ ------------------RFRVLSHR-----------------------HRDGYNTADIE YLEDE------------------------------------------------------- ------------------------------------------------------------ ------------KVEGPEYEELAALHDSVHQQSVS----------------------WFA --SLQDRMKEQILS-----HFGVMPDREPEPQSNPS------------------------ ---------------GPAWSWWI------------------------L-----AVLPLER K---AQLAILGMTS-----------------------LKER------------------- -------------------------LL--------------AIRRILVIITRKMNSRQEL ANARERNN----------------------------------- >O_latipes_ENSORLP00000020860 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------Q QEPSPPSSLEGSKPGFPRKILANCLEDKHLCNSCEKILRRPLQ-AQCGHRFCCFCFNRTV -----------SSGPQKCSACI-KEDLFEEPTSILK-QGGAFHDNAARREVEALAAVCPN -----------------EGCTWTGTVKEYE-ASH--EGSCDFTIIMCP-------SCKEL MRANEQER----HNERECP---ERTLNCKYCKEPFLLKNI-K--AHDE-ICPKYPMMCEG -CAK--KKIPREKYVDHI-KFCSKFKAPCR-FHVVGCDT-S---VEKEKIHDHERQCSYE HLNLLL--HFIMGIKGVCAATLATS-------FTPLHSAMGAALELQ------------- -------------------LQSEKTKVAEL------------SRRCQELE--LKVST--- ---------------FENIVCILNRE-----------LERSCATMEAYNRQHRLDQDKIE ILSNK--------------------------VRQL-----E------------------- ------------------------------------------------------------ ------------RTVSLRDLSIVEMEGKMKDMSAAT---------------YDGIFIWKI S-DFTKKRQDAMAG-----RA--PAMFSPAFYTSKY-GYKM-------CLRIYLN----- --------GDGTGR-GTHLSLFF---VVMR-----------GHSDALL-----K-WPFNQ K---VTLMLLDQNN-----R-EHIIDAFRPDISSSS-FQRP------------VSDMNIA S-GCPL-------------------FCPLSKLDSKNS----YIRDETIFIKAIVDL---- ----------------SGL------------------------ >C_intestinalis_ENSCINP00000001022 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MDTAD----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------S--RHQSGENSSFASSQPE S--------VDQIPQNHL-NESPYVLNNEA-LSLESSLT-T---GDLNSVKAQCEYSHKI LQRQLQ--EMKNAVE-----LEMRK-RESDRDGNVLRANI-TKLEQRLTALQRMTAQQTD RSLALKKEVGDNDAANKRANTDLTQKVEEI------------AREIAQIK--EKQNE--- ---------------LER-------------------------KIESTSSSR--EQMAPE NLSQM--------------------------VDAF-----E------------------- ------------------------------------------------------------ ------------RQLGMYDVRIADMDQRFQVLETTS---------------YSGVVIWKI R-DFSRRKREAVSG-----RT--LSLYSQPFYTSRY-GYKM-------CARVYLN----- --------GDGMGK-GTHMSLFF---VVMK-----------GEYDALL-----P-WPFRQ K---VTLMLLDQGM----DR-RHLSDTFRPDPTSSS-FKKP------------TSDMNIA S-GCPL-------------------FVAHNVIEGSS-----YVKEDTIFLRIHVDT---- ----------------SDL---------------------ENF >D_rerio_ENSDARP00000079014 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MDAGFGSTFPAVP QVAKAE--TNYKQHRRTPSTSSTLTYSTRDDDDGMPPISTPRRSDSAISVRSLHSESNMS L--RSTFSLHEEEEDTEPQVFAEQPSVKLCCQLCCSVFKDPVI-TTCGHTFCRRCAL--- -------------TSEKCPVDN----------SKLT---VVVNNIAVAEQIGELFIHCKY GCRPAASGKSGAYEVDPLGCPFTIKLSTRK--DH--EVSCDYRPVRCPNN---------- -----------------------------------------P-------NCP-------- -------PLLTMNLEAHL-KECEHIK--CP-HSKYGCTF-I---GNQDTYETHLEVCKFE GLK-----EFLQQTDDRFHEMQVTL-AQKDQDISFLRSML-------------------- ------------------------------------------GKLSEKLD--QLEKN--- ---------------LELKFDVLDEN-----------QSKLSEDLMEFRRDASMLNDELS HINAR--------------------------LNMGILGSYDPQQIFKCKGTFVGHQGPVW CLCVYSTGDLLFSGSSDKSIKVWDTCTTYKCQKTLEGHDGIVLALCIQGNKLYSGSADCT IIVWDIQTLQKVNTIRAHDNPVCTLVSSHNMLFSGS---------------LKAIKVWDI V-GTELKLKKELTGLNHWVRA--LVASQNHLYSGSYQTIKIWDIRSLECVHV-LQ----- --------TSG----GSVYSIAVTNHHIVC-----------GTYENLI-----HVWDIES K---EQVRTLTGHVGTVYAL-AVISTPDQTKVFSAS-YDRS------------LRVWSMD N----M-------------------ICTQTLLRHQGSVTALAVSRGRLFSGAVDST---- ----------------VKF---------------------WSC >G_gallus_ENSGALP00000027564 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MGTTGDDMALAEQ--NASLNP L--CFECGQQHWTRENHLYNYQNEVDDDLVCHICLQPLLQPLD-TPCGHTFCYKCLRNFL ------------QEKDFCPLDR----------KRLHFKLCKKSSILVHKLLDKLLVLCPF -------------------------------SS----------------------VCQEV MQRCDLAA----HLKNRCPGASHRRVALERRRASKLQAEA-E--GEAGPGGPEHPNSVSV DAEQSIVPAEQSFT-PALPAWADEPGIDNPPFEENTGADTN---QQPPTLPEGEITTIEI H-------RSNPYIELGISIVGGNETPLINIVIQEVYRDGIIARDGRLLAGDQILQVNSF DISNVSHN-----------HARAVLSQPCT------------VLHLTVLRERRFGSRTHG HTDTTTTTTTSSSSRDDSFQVTLHKR-----------DSSEQLGIKLVRRTDEPGVFILD LLEGG--------------------------LAAQDGRLCS------------------- ------------------------------------------------------------ --------NDRVLAINGHDLKHGTPELAAQVIQASGER-------------VNLIISRPM KSQTVSIIRDTGTH-----NSNPHQHQSQQLFHCRPNSHKD-LSQCVTCQEKHITVKKEP HESLGMTVAGGRGSKSGELPIFV---TSVQPHGCLARDGRIKRGDVLLNINGIDLTNLSH S---EAVAMLKASAASSVVA-LKALEVQIVEEQPQA-NEEQLSTISENEYDASWSPSWVM WLGLPSCLHSCHDVVLRRSNLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYFDGRLKC GDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVICWPGSLI >B_taurus_ENSBTAP00000020741 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MGTTSDEMGSVEQTLSSSFNP L--CFECGQQHWTRENHLYNYQDEVDDDLVCHICLQPLLQPLD-TPCGHTFCCKCLRNFL ------------QEKDFCPLDR----------KKLHFKSCKKSSILVHKLLDKLLISCPF -------------------------------SS----------------------VCHDV MQRCDLEG----HLKNRCPGASHRRAALEKRKTSKTQMEI-E--NENGTTVTDLPAALSP ETD----CSGRTLTSASLPSWTEEPGLDNPAFEESPAGDTT---PQPLSLPEGEITTIEI H-------RSNPFIRLGISIVGGNETPLINIVIQEVYRDGVIAKDGRLLAGDQILQVNNY NISSVSHN-----------YARAVLSQPCS------------TLQLTVLRERRFGSRAHG HPE-------GGSPREEVFPVVLHKR-----------DSAEQLGIKLVRRTDEPGVFILD LLEGG--------------------------LAAQDGRLSS------------------- ------------------------------------------------------------ --------NDRVLAINGHDLKHGTPELAAQIIQASGER-------------VSLTIARPG KPQPGSTVREAGTQ-----SS--SQHHTQTLPYNRPSSHKD-LAQCVTCQEKHITIKKEP HESLGMTVAGGRGSKSGELPIFV---TSVPPHGCLARDGRIKRGDILLNINGIDLTNLSH S---EAVAMLKASATSPTVA-LKALEVQVVEEAAQG-LDEPLSAVSENEYDASWSPSWVM WLGLPSALHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKC GDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVICWPGSLV >T_guttata_ENSTGUP00000011953 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MGTAGDDMAAVEQ--NASLNP L--CFECGQQHWTRENHLYNYQNEVDDDLVCHICLQPLLQPLD-TPCGHTFCYKCLRNFL ------------QEKDFCPLDR----------KRLHFKLCKKSSILVHKLLDKLFVLCPF -------------------------------SS----------------------VCQEV MQRCDLAA----HLKNRCPGASHRRVALERRKTSKLQAEA-E--GESGLGGPEQPSSLSP DTDQGIVPAEPSFTSPALPVWTDEPGIDNPPFEENTVADTN---QQPPTLPEGEITTIEI H-------RSNPYIELGISIVGGNETPLINIVIQEVYRDGIIARDGRLLAGDQILQVNSF DISNVSHN-----------HARAVLSQPCS------------VLHLTVLRERRFGSRTHT HAD------TPGSGREDSFQVTLHKR-----------DSSEQLGIKLVRRTDEPGVFILD LLEGG--------------------------LAAQDGRLCS------------------- ------------------------------------------------------------ --------NDRVLAINGHDLKHGTPELAAQVIQASGER-------------VNLIISRPL KSQTVSIIRDPGTH-----NSSSHQHQSQQLFHSRPNSHKD-LSQCVTCQEKHITVKKEP HESLGMTVAGGRGSKSGELPIFV---TSVQPHGCLARDGRIKRGDVLLNINGIDLTNLSH S---EAVAMLKASAASSVVA-LKALEVQIVEEQPQA-DEEQLSTISENEYDASWSPSWVM WLGLPSCLHSCHDVVLRRSNLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYFDGRLKC GDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVICWPGSLI >P_pygmaeus_ENSPPYP00000013488 MSPEPVPPPPPSQCPGCDRAEPIAPCLEEGDEAFRAGEYEMAAELFRSMLSGLAQPDRGL CLRLGDALARAGRLPEALGAFRGAARLGALRPEEMEELAGGLVRAVGLRERPLSAENPGG EPEAPGEGGQAPEPRAPRDLLGCPRCRRLLHKPVTLPCGLTVCKRCVEPGPARPQARRVN VVLSGLLEKCFPAECRLRRLAGQARSLQRQQQPEAALLRCDQALELAPDDNSLLLLRAEL YLTMKNYEQALQDASAACQNEPLLIKGHQVKAQALSGLGRSKEVLKEFLYCLALNPECNS VKKEAQKVMCEVLFSAAENVHENLTSSIQSRLKAQGHSHMDAQALLEEGDAGSSENSSEK SGMLGNTNSSVLYFILGLHFEEDKKALESILPTAPSAGLKRQFPDDVEDAPDLNAPGKIP K--KDLSPQRSPNSETEESQGLSLDVTDFECALCMRLLFEPVT-TPCGHTFCLKCLERCL ------------DHAPHCPLCK----------DKLS-ELLASRNFNITVLAEELIFRYLP ---------DELSDRKRIYDEEMSELSNLTRDVPIFVCAMAFPTVPCPL----------- ------------HVFEP-----RYRLMIRRCMETGTKRFG-------------------- --------------------MCLSAEHAG--LSEYGCMLEI---KDVRTFPDGSSVVDAI GIS--------------------------------------------------------- ------------------------------------------------------------ ------------------RFRVLSHR-----------------------YRDGYNTADIE YLEDE------------------------------------------------------- ------------------------------------------------------------ ------------KVEGPEYEELAALHDSVHQQSVS----------------------WFA --SLQDRMKEQILS-----HFGVMPDREPEPQSNPS------------------------ ---------------GPAWSWWI------------------------L-----AVLPLER K---AQLAILGMTS-----------------------LKER------------------- -------------------------LL--------------AIRRILVIITRKMNSRQEL ANARERNN----------------------------------- >X_tropicalis_ENSXETP00000034856 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MTSNKNPRFNHFSAGASNLTLTENSNGTRMETTFGPAFSAVT TITKADGT----KHRRTPSTSSTLAFSPRDEDDVMPPISTPRRSDSAISVRSLHSESTMS L--RSTFSLHEEEEEPDPLVFAEQPSVKLCCQLCCSVFKDPVI-TTCGHTFCRRCAL--- -------------TSEKCPVDN----------AKLT---VVVNNIAVAEQIGELFIHCKY GCHPSSNGKPVTFEVDPRGCPFTIKLSARK--DH--EGSCDYRPVRCPNN---------- -----------------------------------------P-------NCP-------- -------PLLKMNLEAHL-KECEHIK--CP-HSKYGCTF-I---GNQDTYETHLETCKFE GLK-----EFLQQTDDRFHEMQVAM-TQKDQEIAFLRSML-------------------- ------------------------------------------GKLSEKID--QLEKN--- ---------------LELKFDVLDEN-----------QSKLSEDLMEFRRDASMLNDELS HINAR--------------------------LNMGILGSYDPQQIFKCKGTFVGHQGPVW CLCVYSIGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGSKLYSGSADCT IIVWDIQTLLKVNTIRAHDNPVCTLVSSHNMLFSGS---------------LKAIKVWDI V-GTDLKLKKELTGLNHWVRA--LVASQNYLYSGSYQTIKIWDIRTLECAHV-LQ----- --------TSG----GSVYSIAVTNHHIVC-----------GTYENLI-----HVWDIES K---EQVRTLTGHVGTVYAL-AVISTPDQTKVFSAS-YDRS------------LRVWSMD N----M-------------------ICTQTLLRHQGSVTALAVSRGRLFSGAVDST---- ----------------VKV---------------------WTC >B_taurus_ENSBTAP00000024853 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MDAVELARKLQEEATCSICLDYFTDPVM-TTCGHNFCRECIQLTW EKARGQKKRRKRKGSFPCPECR----------ELSP-QRNLRPNRLLTKVAE-------- ------------------------MVRQHP---------SPQSRDLCQ-------VHREL LKLFCEDD---------------QRPICIICRESQEHRPH-R-------VVPIEEAVQEY -------KLKLEEDMEHLREEMTKTEELQA-KEEHTLAEWQ------MRTQDPRKAMVFT EFK-----SGLRTVPSAQAGHSKDAASNSAQV-TGIQXST-------------------- --------------------ASLKQQSHSL------------ERLLLQLEDRNEHTPLQM LQD------------MKGLLSRKSSL-------SVQYPEATSIML-KTICRVPGQIEVLK SFQE--------------------DVVPDPSTAYP-----Y------------------- ------------------------------------------------------------ ------------LLLYESRQR-RYLSTPMDGTPCGKDRFLAYPCAVGQEIYSSGRHYWEV GMNLTGDALWALGV-----CRDNVSRRNRVPKSPEN-GFWV--------VQLCKG----- --------KRYAPAAFTPIPVTL---AEPP-----------SHMGIFL-----D---FEA G----ELAFYNAND-----G-SHLHSYSQPA------FPGP------------------- -------------------------LQPFFCLGAPKSGQM-VISTVTLWVKG-------- ------------------------------------------- >R_norvegicus_ENSRNOP00000001021 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -M-AETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVI-IECGHNFCKACITRWW EDL---------ERDFPCPVCR----------KTSR-YRSLRPNRQLGSMVE-------- ------------------------IAKQLQ---T--VKRKIRDESLCS-------QHHEP LSLFCYED---------------QEAVCLICAISHTHRAH-T-------VVPMDDATQEY -------KEKLQKCLEPLEQKLQEITCCKA-SEERKPGELK-------RLVESRRQQILK EFE-----ELHRRLDEEQQTLLSRLEEEEQDILQRLRENA-------------------- --------------------AHLGDRRRDL------------AHLAAEVEGKCLQSGFEM LK--------------VRPLLLCEKV-------KTMEVTSVSIELEKNFSHFPRQYFALR KILKQLIAPLWLLPPA--------DVTLDPETAHP-----N------------------- ------------------------------------------------------------ ------------LVLSEDRKSVKFVETRLRDLPDTPQRFTFYPCVLATEGFTSGRHYWEV --EVGDKTHWAVGV-----CRDSVSRKGELTPLPET-GYWR--------VRLWNG----- --------DKYAATTTPFTPLHI---KVKP-----------KRVGIFL-----D---YEA G----TLSFYNVTD-----R-SHIYTFTDT-------FTEK------------------- --LWPL-------------------FYPGIRAGRKNAAP--------LTIRPPTDWE--- ------------------------------------------- >G_gallus_ENSGALP00000009249 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MSSNKNARFNRFSSGTPSITTSENTNGTRMETTFGPAYSAVT TITKADGTNTFKQHRRTPSSSSTLTYSPRDEDDGMPPISTPRRSDSAISVRSLHSESNMS L--RSTFSLHEEEEEPEPLVFAEQPSVKLCCQLCCSVFKDPVI-TTCGHTFCRRCAL--- -------------TSEKCPVDN----------AKLT---VVVNNIAVAEQIGELFIHCKY GCRPAASSKPAAFEVDPRGCPFTIKLSVRK--DH--ESSCDYRPVRCPNN---------- -----------------------------------------P-------SCP-------- -------PLLKMNLEAHL-KECEHIK--CP-HSKYGCTF-I---GNQDTYETHLEMCKFE GLK-----EFLQQTDDRFHEMQVAM-AQKDQEIAFLRSML-------------------- ------------------------------------------GKLSEKID--QLEKN--- ---------------LELKFDVLDEN-----------QSKLSEDLMEFRRDASMLNDELS HINAR--------------------------LNMGILGSYDPQQIFKCKGTFVGHQGPVW CLCVYSIGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGNKLYSGSADCT IIVWDIQNLQKVNTIRAHDNPVCTLVSSHNMLFSGS---------------LKAIKVWDI V-GTELKLKKELTGLNHWVRA--LVASQNYLYSGSYQTIKIWDIRNLECVHV-LQ----- --------TSG----GSVYSIAVTNHHIVC-----------GTYENLI-----HVWDIET K---EQVRTLTGHVGTVYAL-AVISTPDQTKVFSAS-YDRS------------LRVWSMD N----M-------------------ICTQTLLRHQGSVTALAVSRGRLFSGAVDST---- ----------------VKV---------------------WTC