10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0072450 MKTSYPPKASDFVDY--------------------------------------------------------------------------------------------------------- A_gambiae_AGAP007342-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003731-PA ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000020125 -------MASQVQVF--------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000029014 -------MASQLQVF--------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000017168 -------MASHVQVF--------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000020840 PPPLVTGMASQVQVF--------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000062342 MAPVYEGMASQVQVF--------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000005223 -------MASQVLVY--------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000016703 ------GMASHVQVF--------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000006000 -------MASHVQVF--------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000003569 -------MASQLQVF--------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000020844 LLPLYKCMASHVQVF--------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000022455 HPSLVTGMASQVQVF--------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000003337 F-PFLVGMASHVQVF--------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000033846 LQPVYESMASHVQVF--------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000263551 LQPVYESMASHVQVF--------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000010384 -------MASHVQVF--------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000045457 -------MASHVQVF--------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000011747 ------GMASHVQVF--------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000007300 -------MASHVQVF--------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000006052 -------MASQVLVY--------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000003875 -------MASQVLVY--------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000002998 -------MASQLQVF--------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000019093 -------MASQVLVY--------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000304226 -------MASQVLVY--------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000012226 -------MASQVLVY--------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000002399 -------MASQLQVF--------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000013135 -------MASQLQVF--------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000013694 -------MASQLQVF--------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000010754 -------MASQVLVY--------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000018143 -------MASQVLVY--------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000358574 -------MASQLQVF--------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000001943 -------MASQLQVF--------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000015051 -------MASQLQVF--------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000001607 -------MASQLQVF--------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000106754 -------MASQVLVY--------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000039475 -------MASQVLVY--------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000113998 -------MASQLQVF--------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000003036 -------MASQVLVY--------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000052927 -------MASQLQVF--------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000023838 -------MASQVLVY--------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000027188 -------MSSQLQVF--------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000015775 -------MASQVLVY--------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000083736 -------MASQVLVY--------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000017894 QFPTFTGMASQVQVF--------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000010045 -------MASQVLVY--------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000015420 -------MASQVLVY--------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000004224 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020253 LRPVYESMASHVQVF--------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000021106 -------MASQVLVY--------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000003977 LQPV-ESMASHVQVF--------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000000924 -------KGAGCCFS--------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000000494 ------------MII--------------------------------------------------------------------------------------------------------- A_gambiae_AGAP004833-PA -------MASREVIIASDDSDTEEDQSPHNKLSEQKHNSSSRKHKKHKRHKKSSKSEKGDKQHKPKKHKKHKRKHRGEEDDQESSSEGEHAKNGASAEPRKVEQTIRAKQPMDDDEHSDE 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0072450 --------------------------------------------------------------------AVAGGGGSGF----CSGLGAGLS-----------VRATSFYGDQTVTATTDG A_gambiae_AGAP007342-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003731-PA ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000020125 ------------------------------------------------------------------SPR--TLQSSAF----FSVKKLKVE-----QSCNWDMTGYGSHSKVYSHSSSKN M_domestica_ENSMODP00000029014 ------------------------------------------------------------------SPP--SVSSSAF----CSAKKLKTE-----PSG-WDVSGPSSNEKYYTHSKTLS M_domestica_ENSMODP00000017168 ------------------------------------------------------------------SPH--TLQSSAF----CSVKKLKVE-----PSSNWDMTGYGTHSKVYSQSKNVQ T_rubripes_ENSTRUP00000020840 ------------------------------------------------------------------SPH--TLQSSAF----FSVKKMKVE-----QSCNWDMTGYGTHSKVYSHSSSKN D_rerio_ENSDARP00000062342 ------------------------------------------------------------------SPH--TLQSSAF----FSVKKLKVE-----QSCNWDMTGYGTHSKVYSQNSKQS T_guttata_ENSTGUP00000005223 ------------------------------------------------------------------PPYVYQTQSSAF----CSVKKLKLE-----PSS--CVYHERTYPQIYVNGKNFG A_carolinensis_ENSACAP00000016703 ------------------------------------------------------------------SPH--TLQSSAF----CSVKKLKVE-----PSSNWDMTGYGTHSKVYSQSKNVQ C_familiaris_ENSCAFP00000006000 ------------------------------------------------------------------SPH--TLQSSAF----CSVKKLKVE-----PSSTWDMTGYGSHSKVYSQSKNVP X_tropicalis_ENSXETP00000003569 ------------------------------------------------------------------SPS--SVSSSAF----CSAKKLKVE-----PSG-WDVTGQGSSNKYYTHTKNLP G_gallus_ENSGALP00000020844 ------------------------------------------------------------------SPH--TLQSSAF----CSVKKLKVE-----PSSNWDMTGYGTHSKVYSQSKSVQ T_nigroviridis_ENSTNIP00000022455 ------------------------------------------------------------------SPH--TLQSSAF----FSVKKMKVE-----QSCNWDMTGYGTHGRVYSHSSSKN M_mulatta_ENSMMUP00000003337 ------------------------------------------------------------------SPH--TLQSSAF----CSVKKLKIE-----PSSNWDMTGYGSHSKVYSQSKNIP P_troglodytes_ENSPTRP00000033846 ------------------------------------------------------------------SPH--TLQSSAF----CSVKKLKIE-----PSSNWDMTGYGSHSKVYSQSKNIP H_sapiens_ENSP00000263551 ------------------------------------------------------------------SPH--TLQSSAF----CSVKKLKIE-----PSSNWDMTGYGSHSKVYSQSKNIP R_norvegicus_ENSRNOP00000010384 ------------------------------------------------------------------SPH--TLQSSAF----CSVKKLKVE-----PSSNWDMTGYGSHSKVYSQSKNIP M_musculus_ENSMUSP00000045457 ------------------------------------------------------------------SPH--TLQSSAF----CSVKKLKVE-----PSSNWDMTGYGSHSKVYSQSKNIP T_guttata_ENSTGUP00000011747 ------------------------------------------------------------------SPH--TLQSSAF----CSVKKLKVE-----PSSNWDMTGYGTHSKVYNQGKNVQ E_caballus_ENSECAP00000007300 ------------------------------------------------------------------SPH--TLQSSAF----CSVKKLKVE-----PSSNWDMTGYGSHSKVYSQSKNIP P_troglodytes_ENSPTRP00000006052 ------------------------------------------------------------------PPYVYQTQSSAF----CSVKKLKVE-----PSS--CVFQERNYPRTYVNGRNFG P_pygmaeus_ENSPPYP00000003875 ------------------------------------------------------------------PPYVYQTQSSAF----CSVKKLKVE-----PSS--CVFQERNYPRTYVNGRNFG G_gallus_ENSGALP00000002998 ------------------------------------------------------------------SPP--SVSSSAF----CSAKKLKVE-----PSV-WDVSGQSSSDKYYTHSKNLP G_gallus_ENSGALP00000019093 ------------------------------------------------------------------PPYVYQTQSSAF----CSVKKLKLE-----PSS--CVYHERAYPQIYVNGKNFG H_sapiens_ENSP00000304226 ------------------------------------------------------------------PPYVYQTQSSAF----CSVKKLKVE-----PSS--CVFQERNYPRTYVNGRNFG M_domestica_ENSMODP00000012226 ------------------------------------------------------------------PPYVYQTQSSAF----CSVKKLKVE-----PSS--CVYHEKTYPQTYLNGRNFG A_carolinensis_ENSACAP00000002399 ------------------------------------------------------------------SPP--SVSSSAF----CSAKKLKVE-----PSS-WDVSGQSNSDEYYSHSKNLP E_caballus_ENSECAP00000013135 ------------------------------------------------------------------SPP--SVSSSAF----CSAKKLKIE-----PSG-WDVSGQSSNDKYYTHSKTLP C_familiaris_ENSCAFP00000013694 ------------------------------------------------------------------SPP--SVSSSAF----CSAKKLKIE-----PSG-WDVSGQSSNDKYYTHSKTLP C_familiaris_ENSCAFP00000010754 ------------------------------------------------------------------PPYVYQTQSSAF----CSVKKLKIE-----PSS--CVFQERNYPRTYVNGKNVG E_caballus_ENSECAP00000018143 ------------------------------------------------------------------PPYVYQTQSSAF----CSVKKLKVE-----PSS--CVFQERNYPRTYLNGGNVG H_sapiens_ENSP00000358574 ------------------------------------------------------------------SPP--SVSSSAF----CSAKKLKIE-----PSG-WDVSGQSSNDKYYTHSKTLP P_troglodytes_ENSPTRP00000001943 ------------------------------------------------------------------SPP--SVSSSAF----CSAKKLKIE-----PSG-WDVSGQSSNDKYYTHSKTLP B_taurus_ENSBTAP00000015051 ------------------------------------------------------------------SPP--SVSSSAF----CSAKKLKIE-----PSG-WDVSGQSSNDKYYTHSKTLP T_guttata_ENSTGUP00000001607 ------------------------------------------------------------------SPP--SVSSSAF----CSAKKLKVE-----PSV-WDVSGQSSSDKYYTHSKNLP M_musculus_ENSMUSP00000106754 ------------------------------------------------------------------PPYVYQTQSSAF----CSVKKLKVE-----PSG--CVFQERTYPQIHVNGRNFG B_taurus_ENSBTAP00000039475 ------------------------------------------------------------------PPYIYQTQSSAF----CSVKKLRVE-----PSS--CVFQERNYPRTYVNGRNVG M_musculus_ENSMUSP00000113998 ------------------------------------------------------------------SPP--SVSSSAF----CSAKKLKIE-----PSG-WDVSGQSSNDKYYTHSKTLP A_carolinensis_ENSACAP00000003036 ------------------------------------------------------------------PPYVYQTQSSAF----CSVKKLKVE-----PSS--CVYHEKTFPQIYVNGKNFG R_norvegicus_ENSRNOP00000052927 ------------------------------------------------------------------SPP--SVSSSAF----CSAKKLKIE-----PSG-WDVSGQSSNDKYYTHSKTLP O_anatinus_ENSOANP00000023838 ------------------------------------------------------------------PPYVYQTQSSAF----CSSKKLRVE-----PSS--CVYHERTYPRTCVNGRNFA T_rubripes_ENSTRUP00000027188 ------------------------------------------------------------------SPP--SVSSSAF----CRVKKLKVE------SNVWDVTTSEAFSSIAGQTAYT- R_norvegicus_ENSRNOP00000015775 ------------------------------------------------------------------PPYVYQTQSSAF----CSVKKLKVE-----PSG--CVFQERACPQIHVNGRHFG D_rerio_ENSDARP00000083736 ------------------------------------------------------------------PPHVFQTQTSAF----CSVKKLKVE-----PRN--CVYHERAYPQTYLNGRTLG G_aculeatus_ENSGACP00000017894 ------------------------------------------------------------------SPH--TLQSSAF----FSVKKLKVE-----QSCNWDMTGYGTHSKVYSHNSSKN T_rubripes_ENSTRUP00000010045 ------------------------------------------------------------------PPHIYQTQTSAF----SSVKKLKVE-----PSK--CVSKERAHPRTYLNSRTLS O_latipes_ENSORLP00000015420 ------------------------------------------------------------------PSHLHSAQTSALGTSSCGTSRHKGEVHRSNNTS--RAFQHRPPPKTYVIGVNYG T_rubripes_ENSTRUP00000004224 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020253 ------------------------------------------------------------------SPH--TLQSSAF----CSVKKLKIE-----PSSNWDMTGYGSHSKVYSQSKNIP G_aculeatus_ENSGACP00000021106 ------------------------------------------------------------------PPHIYQTQTSAF----SSVKKLKAE-----PSS--CVYHERAHLSTHLNRRTLG G_gorilla_ENSGGOP00000003977 ------------------------------------------------------------------SPH--TLQSSAF----CSVKKLKIE-----PSSNWDMTGYGSHSKVYSQSKNIP G_aculeatus_ENSGACP00000000924 ------------------------------------------------------------------SRKAGEPVFSPAHGG----------------SQ---TASPGALPRLRNHNLTGG G_aculeatus_ENSGACP00000000494 ------------------------------------------------------------------SRKPEGPIATARHGDGLYDSYMRTDHILKDEAD---TNSPAGLPPMPKHTVVSN A_gambiae_AGAP004833-PA RHKRAEHVARSKNNGSTKDIVEKRKGHISTDPDKLVQMLTQNLEKRKEDVVSVESESDGTAVEDAPSPDVAVIEDDELNLEDLMRQKALLQARLGEYATDEEDDGQGKVSRAEMNSRERP 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0072450 T----------------------------------------------------------------------------------------------------------------------- A_gambiae_AGAP007342-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003731-PA ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000020125 A----------------------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000029014 A----------------------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000017168 P----------------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000020840 L----------------------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000062342 V----------------------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000005223 I----------------------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000016703 S----------------------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000006000 P----------------------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000003569 V----------------------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000020844 S----------------------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000022455 L----------------------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000003337 P----------------------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000033846 L----------------------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000263551 L----------------------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000010384 P----------------------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000045457 P----------------------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000011747 S----------------------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000007300 P----------------------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000006052 N----------------------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000003875 N----------------------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000002998 A----------------------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000019093 I----------------------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000304226 N----------------------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000012226 I----------------------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000002399 A----------------------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000013135 T----------------------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000013694 A----------------------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000010754 N----------------------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000018143 N----------------------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000358574 A----------------------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000001943 A----------------------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000015051 A----------------------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000001607 A----------------------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000106754 N----------------------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000039475 N----------------------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000113998 A----------------------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000003036 I----------------------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000052927 A----------------------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000023838 I----------------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000027188 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000015775 N----------------------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000083736 I----------------------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000017894 L----------------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000010045 I----------------------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000015420 I----------------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000004224 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020253 P----------------------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000021106 I----------------------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000003977 L----------------------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000000924 P----------------------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000000494 K----------------------------------------------------------------------------------------------------------------------- A_gambiae_AGAP004833-PA VKKKKVDTNETVITIDGDSTPDDDKLRKKPSIVTNRMSRGNKEDAHVGQRGNNADADTKRSKDQQIHPAEARARQIERDRDRDRETRTRDDRRNREEDNYKRRMAEERYEREKARERDRD 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0072450 --------------------------------------------------------------------------------------------------RHQEQQQQQ------------- A_gambiae_AGAP007342-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003731-PA ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000020125 --------------------------------------------------------------------------------------------------SAAS---GIN-SSLQVASAT-- M_domestica_ENSMODP00000029014 --------------------------------------------------------------------------------------------------TQGQ----AS-SSHQVTSFN-- M_domestica_ENSMODP00000017168 --------------------------------------------------------------------------------------------------SQ-PAATTVS-TSLQIPNPS-- T_rubripes_ENSTRUP00000020840 --------------------------------------------------------------------------------------------------SAASGPLGIN-SSLQVASST-- D_rerio_ENSDARP00000062342 --------------------------------------------------------------------------------------------------SVAP--VGINGASLQVSNSS-- T_guttata_ENSTGUP00000005223 --------------------------------------------------------------------------------------------------S-PHRV-S---TFFQTKNP--- A_carolinensis_ENSACAP00000016703 --------------------------------------------------------------------------------------------------AQ--AAATIN-ASLQIPNPN-- C_familiaris_ENSCAFP00000006000 --------------------------------------------------------------------------------------------------SQ-PATTTVS-TSLPIPNPS-- X_tropicalis_ENSXETP00000003569 --------------------------------------------------------------------------------------------------AQGH----AS-SSHQVAGFS-- G_gallus_ENSGALP00000020844 --------------------------------------------------------------------------------------------------SQAAAAAAVN-ASLQIPNPS-- T_nigroviridis_ENSTNIP00000022455 --------------------------------------------------------------------------------------------------SATGGPLGIN-------GSA-- M_mulatta_ENSMMUP00000003337 --------------------------------------------------------------------------------------------------SQ-PATTTVS-TSLPVPNPS-- P_troglodytes_ENSPTRP00000033846 --------------------------------------------------------------------------------------------------SQ-PATTTVS-TSLPVPNPS-- H_sapiens_ENSP00000263551 --------------------------------------------------------------------------------------------------SQ-PATTTVS-TSLPVPNPS-- R_norvegicus_ENSRNOP00000010384 --------------------------------------------------------------------------------------------------SQ-PASTTVS-TSLPIPNPS-- M_musculus_ENSMUSP00000045457 --------------------------------------------------------------------------------------------------SQ-PASTTVS-TSLPIPNPS-- T_guttata_ENSTGUP00000011747 --------------------------------------------------------------------------------------------------SQAAATAAVN-ASLQIPNPS-- E_caballus_ENSECAP00000007300 --------------------------------------------------------------------------------------------------SQ-PATTTVS-TSLPIPNPS-- P_troglodytes_ENSPTRP00000006052 --------------------------------------------------------------------------------------------------SHPLTK-G---SAFQTKIP--- P_pygmaeus_ENSPPYP00000003875 --------------------------------------------------------------------------------------------------SHPPTK-G---SAFQTKIP--- G_gallus_ENSGALP00000002998 --------------------------------------------------------------------------------------------------AQGQ----AS-SSHQVANFS-- G_gallus_ENSGALP00000019093 --------------------------------------------------------------------------------------------------S-PHRV-S---TFLQTKNP--- H_sapiens_ENSP00000304226 --------------------------------------------------------------------------------------------------SHPPTK-G---SAFQTKIP--- M_domestica_ENSMODP00000012226 --------------------------------------------------------------------------------------------------SHPSIK-E---STFHTKIP--- A_carolinensis_ENSACAP00000002399 --------------------------------------------------------------------------------------------------TQGP----AS-SSHQVANFS-- E_caballus_ENSECAP00000013135 --------------------------------------------------------------------------------------------------TQGQ----AN-SSHQVANFN-- C_familiaris_ENSCAFP00000013694 --------------------------------------------------------------------------------------------------TQGQ----AN-SSHQVANFN-- C_familiaris_ENSCAFP00000010754 --------------------------------------------------------------------------------------------------SHPPTK-G---SVFQTKIP--- E_caballus_ENSECAP00000018143 --------------------------------------------------------------------------------------------------SHPPTK-G---SAFQTKIP--- H_sapiens_ENSP00000358574 --------------------------------------------------------------------------------------------------TQGQ----AN-SSHQVANFN-- P_troglodytes_ENSPTRP00000001943 --------------------------------------------------------------------------------------------------TQGQ----AN-SSHQVANFN-- B_taurus_ENSBTAP00000015051 --------------------------------------------------------------------------------------------------TQGQ----AN-SSHQVANFN-- T_guttata_ENSTGUP00000001607 --------------------------------------------------------------------------------------------------AQGQ----AS-SSHQVANFS-- M_musculus_ENSMUSP00000106754 --------------------------------------------------------------------------------------------------SHPSTK-G---SAFQTKIP--- B_taurus_ENSBTAP00000039475 --------------------------------------------------------------------------------------------------SHPPTK-G---SAFQTKIP--- M_musculus_ENSMUSP00000113998 --------------------------------------------------------------------------------------------------TQGQ----AS-SSHQVANFN-- A_carolinensis_ENSACAP00000003036 --------------------------------------------------------------------------------------------------AQPPSRVG---TLLQATNL--- R_norvegicus_ENSRNOP00000052927 --------------------------------------------------------------------------------------------------TQGQ----AS-SSHQVANFN-- O_anatinus_ENSOANP00000023838 --------------------------------------------------------------------------------------------------SQPPTK-D---PTFPTKIP--- T_rubripes_ENSTRUP00000027188 --------------------------------------------------------------------------------------------------FAPAMA---------------- R_norvegicus_ENSRNOP00000015775 --------------------------------------------------------------------------------------------------PLPSTK-G---SAFQTKIP--- D_rerio_ENSDARP00000083736 --------------------------------------------------------------------------------------------------AYPTKL-T---ASFKTRDSV-- G_aculeatus_ENSGACP00000017894 --------------------------------------------------------------------------------------------------SAATGPLGIN-SSLQVAKSA-- T_rubripes_ENSTRUP00000010045 --------------------------------------------------------------------------------------------------VHPTKQ-A---HAFG------- O_latipes_ENSORLP00000015420 --------------------------------------------------------------------------------------------------AYPNNVLPSS-TGADLGRLHQG T_rubripes_ENSTRUP00000004224 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020253 --------------------------------------------------------------------------------------------------SQ-PATTTVS-TSLPVPNPS-- G_aculeatus_ENSGACP00000021106 --------------------------------------------------------------------------------------------------VQPTKQ-A---RSFVNPDSAAG G_gorilla_ENSGGOP00000003977 --------------------------------------------------------------------------------------------------SQ-PATTTVS-TSLPVPNPS-- G_aculeatus_ENSGACP00000000924 --------------------------------------------------------------------------------------------------RAAMSQAVQLSSQSQVTQLY-- G_aculeatus_ENSGACP00000000494 --------------------------------------------------------------------------------------------------TVMREQVTVRGGQLKVKYMY-- A_gambiae_AGAP004833-PA RERERDRERARARQRERDRSLERRRDRRGYSPRDRSRERRSIERDRVGTRMDRERDRERFRDRDRARDYGRGMQRNGRDGRAGGKGRKPDDDRFKDSLSEGLKQQKESSSESEIADID-- 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0072450 LQQQQQQHILRQPAT-----------SASTSSVAAAATSKRKRQTD------CDC--------------------------------------------------------GCVDSYNS- A_gambiae_AGAP007342-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003731-PA ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000020125 LP-YEQ-ALIFPASA------GHIVVASASSTSG---TI-GS----------LL-------------HNLTRR--------------------------------------STVSLLDT- M_domestica_ENSMODP00000029014 LPSYDQ-SLLLPAPT-----VEHIVVTAADSTGG---AA-TT----------SFQ---NS-------QTLTHR--------------------------------------GNVSLLEP- M_domestica_ENSMODP00000017168 LP-YEQ-TIIFPGST------GHIVVTSASSTS----VS-GQ----------ALG---GP-------HNLMRR--------------------------------------STVSLLDT- T_rubripes_ENSTRUP00000020840 LP-YEQ-TLIFPASA------GHIVVASASSTSG---AV-GS----------LLG--IGV-------HNLTRR--------------------------------------STVSLLDT- D_rerio_ENSDARP00000062342 LS-YEQ-ALLFPAGS------GHIVVASASSTSG---AA-GQ----------LLG-STGSSGSGSGGHNLTRR--------------------------------------STVSLLDT- T_guttata_ENSTGUP00000005223 FDRPRGQSFWLQSNA-----------VALKDTAGATKALAVWAQQP------QLE---AP-------RAGTQG--------------------------------------SWSDILEG- A_carolinensis_ENSACAP00000016703 IP-YEQ-TIIFPAST------GHIVVTSANSTS----VS-GQ----------ALG---GP-------HNLMRR--------------------------------------STVSLLDT- C_familiaris_ENSCAFP00000006000 LP-YEQ-TIIFPGST------GHIVVTSASSTS----VT-GQ----------VLG---GP-------HNLMRR--------------------------------------STVSLLDT- X_tropicalis_ENSXETP00000003569 LPAYEP-NLLIPAAA-----AEHIVVTAADSTDS---GP-TT----------SFQ---NS-------QILTHR--------------------------------------SNVPLLDP- G_gallus_ENSGALP00000020844 IP-YEQ-TIIFPAST------GHIVVTSANSTSGVVAVS-GQ----------TLG---GP-------HNLMRR--------------------------------------STVSLLDT- T_nigroviridis_ENSTNIP00000022455 LP-YEQ-ALIFPASA------SHIVVASASSTSG---AVGGS----------GLGGVVGV-------HNLMRR--------------------------------------STVSLLDT- M_mulatta_ENSMMUP00000003337 LP-YEQ-TIIFPGST------GHIVVTSASSTS----VT-GQ----------VLG---GP-------HNLMRR--------------------------------------STVSLLDT- P_troglodytes_ENSPTRP00000033846 LP-YEQ-TIIFPGST------GHIVVTSASSTS----VT-GQ----------VLG---GP-------HNLMRR--------------------------------------STVSLLDT- H_sapiens_ENSP00000263551 LP-YEQ-TIVFPGST------GHIVVTSASSTS----VT-GQ----------VLG---GP-------HNLMRR--------------------------------------STVSLLDT- R_norvegicus_ENSRNOP00000010384 LP-YEQ-TIIFPGST------GHIVVTSASSTS----VT-GQ----------VLG---GP-------HNLMRR--------------------------------------STVSLLDT- M_musculus_ENSMUSP00000045457 LP-YEQ-TIIFPGST------GHIVVTSASSTS----VT-GQ----------VLG---GP-------HNLMRR--------------------------------------STVSLLDT- T_guttata_ENSTGUP00000011747 IP-YEQ-TIIYPAST------GHIVVTSANSTS----VS-GQ----------TLG---GP-------HNLMRR--------------------------------------STVSLLDT- E_caballus_ENSECAP00000007300 LP-YEQ-TIIFPGST------GHIVVTSASSTS----VT-GQ----------VLG---GP-------HNLMRR--------------------------------------STVSLLDT- P_troglodytes_ENSPTRP00000006052 FNRPRGHNFSLQTSA-----------VVLKNTAGATKVIAAQAQQA------HVQ---AP-------QIGAWR--------------------------------------NRLHFLEG- P_pygmaeus_ENSPPYP00000003875 FNRPRGHNFSLQTSA-----------VVLKNTAGATKVIAAQAQQA------HVQ---AS-------HIGAWR--------------------------------------NRLHFLEG- G_gallus_ENSGALP00000002998 VPAYDQ-NLLLPAPS-----VEHIVVTAADSTGS---SA-TA----------SFQ---NS-------QTLTHR--------------------------------------TNLSLLEP- G_gallus_ENSGALP00000019093 FDRPRGQNVLLQSNA-----------VALKNIAGATKALAAQAQQA------QLE---AP-------RSGTQG--------------------------------------SRADILEG- H_sapiens_ENSP00000304226 FNRPRGHNFSLQTSA-----------VVLKNTAGATKVIAAQAQQA------HVQ---AP-------QIGAWR--------------------------------------NRLHFLEG- M_domestica_ENSMODP00000012226 LNRSRGHNILLQTNT-----------AAFKNTAGATKVLGARAQPP------HVE---AP-------SSGTRG---------------------------------------------S- A_carolinensis_ENSACAP00000002399 IPAYDQ-SLLLPAPS-----VEHIVVTAADSTGS---GG-TT----------SFQ---NS-------QALTHR--------------------------------------ANIALLEP- E_caballus_ENSECAP00000013135 IPAYDQ-GLLLPAPA-----VEHIVVTAADSSAS---AA-TS----------TFQ---SS-------QTLTHR--------------------------------------SNVSLLEP- C_familiaris_ENSCAFP00000013694 IPAYDQ-GLLLPAPA-----VEHIVVTAADSSAS---AA-TS----------TFQ---SS-------QTLTHR--------------------------------------NNVSLLEP- C_familiaris_ENSCAFP00000010754 FNRPRGHNFSLQTSA-----------VVLKNTAGATKVIAAQAQQA------QVE---AP-------QIGAWR--------------------------------------HRLHFLEG- E_caballus_ENSECAP00000018143 FNRPRGHHFSLQTSA-----------VVLKNTTGATKVLAAPAQRA------PVE---AL-------PAGAWQ--------------------------------------HRLGFLEG- H_sapiens_ENSP00000358574 IPAYDQ-GLLLPAPA-----VEHIVVTAADSSGS---AA-TS----------TFQ---SS-------QTLTHR--------------------------------------SNVSLLEP- P_troglodytes_ENSPTRP00000001943 LPAYDQ-GLLLPAPA-----VEHIVVTAADSSGS---AA-TS----------TFQ---SS-------QTLTHR--------------------------------------SNVSLLEP- B_taurus_ENSBTAP00000015051 IPAYDQ-GLLLPAPA-----VEHIVVTAADSSAS---AA-TS----------TFQ---SS-------QTLTHR--------------------------------------SNVSLLEP- T_guttata_ENSTGUP00000001607 IPAYDQ-NLLLPAPS-----VEHIVVTAADSTGS---SA-TA----------SFQ---SS-------QTITHR--------------------------------------SNVSLLEP- M_musculus_ENSMUSP00000106754 FTKPRGHSFSLQAGA-----------IVVKDTAGATKVLAAQAQQA------GVE---AP-------RAVVWR--------------------------------------NRLHFLEG- B_taurus_ENSBTAP00000039475 FNRPRGHNLSLQTSA-----------VVIKNPAGATKVIAAQAPQT------QVE---AP-------QIGAWR--------------------------------------HRFSFLEG- M_musculus_ENSMUSP00000113998 LPAYDQ-GLLLPAPA-----VEHIVVTAADSSGS---AA-TA----------TFQ---SS-------QTLTHR--------------------------------------SNVSLLEP- A_carolinensis_ENSACAP00000003036 FDRPRRDPCLLQTSA-----------VALKNIAGATKILAVQAQQT------EVE---SW--------PGTQE---------------------------------------DLTILDR- R_norvegicus_ENSRNOP00000052927 IPAYDQ-GLLLQAPA-----VEHIVVTAADSSGS---AA-TA----------TFQ---SS-------QTLTHR--------------------------------------SNVSLLEP- O_anatinus_ENSOANP00000023838 SNRPRGRHF-VWPSA-----------IALKTTAGATKVLAVQAQPV------LGE---AL-------QAGTQE--------------------------------------SGFDLPDG- T_rubripes_ENSTRUP00000027188 VPPFAP-SLVFPPAA--PGSRGQVVVRAADSTGS---LPRGSSRRV------AEQ---PT-------SSSYSH--------------------------------------ADVPSETR- R_norvegicus_ENSRNOP00000015775 FSKPRGHSFSLQAGA-----------IVVKDTAGATKVIAAQAQQA------GVE---AP-------RAVVWR--------------------------------------NRLHFLGG- D_rerio_ENSDARP00000083736 IGIHRGQDFPLQTAAVQGVRRQHTITVAQQQKRGASSQEKESEHQD------KGR---VC-------SSGATRAAGRGRGVGSDSQEEGGGGQGGVDEGGGGEDEGDQEDCGGFDLNDS- G_aculeatus_ENSGACP00000017894 LP-YEHPALIFPASV------GHIVVASASSTSG---AA-RS----------LLG-SGGV-------HNLTRR--------------------------------------STVSLLDT- T_rubripes_ENSTRUP00000010045 RDLAGNEQQRQQEQT-----------VTASGGSSGAAGAGGGGRGEGCSGGGQGV---GE-------EEGDR-----------------------------------EEDCGGLNSADS- O_latipes_ENSORLP00000015420 LQFSESEQWALQ-------------------TAGIQREACAKAEED------EIK---SR-------RIQQRG--------------------------------------GFFNCADTG T_rubripes_ENSTRUP00000004224 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020253 LP-YEQ-TIIFPGST------GHIVVTSASSTS----VT-GQ----------VLG---GP-------HNLMRR--------------------------------------STVSLLDT- G_aculeatus_ENSGACP00000021106 VKVRGGQQYTVQT-------------VVVRGVQRQETAAAAQQRQD------TGV---VH-------SQGKEK----------------------------------EEDCGGLNSADG- G_gorilla_ENSGGOP00000003977 LP-YEQ-TIIFPGST------GHIVVTSASSTS----VT-GQ----------VLG---GP-------HNLMRR--------------------------------------STVSLLDT- G_aculeatus_ENSGACP00000000924 EENTNKRPVLTSQPN-----------GLAPLGSTRPGLPLPDRQSS------APE---PP-------NHCRQG--------------------------------------SASSNKSTE G_aculeatus_ENSGACP00000000494 EDSANNRKI-----------------NAISTAATQNSSTEPSKGSG------DPC---GP-------NAVANG--------------------------------------GGVGKL--- A_gambiae_AGAP004833-PA IDDEEDEEKIIEKRRKEREALLKLKQVSMISTAPSSRNESRETTSQ------RAEDNDCDGTDQSLTPPIPNERK------------------------------------ALMDKVERK 610 620 630 640 650 660 670 680 690 700 710 720 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0072450 -----SHGPPVQQDSSAAAGA------GSVGSKAGSGPGP----DGIGPISSLKTAHTKVATSGGHANTQPP------SKRSSSGADGDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVV A_gambiae_AGAP007342-PA ---------------------------------------------MGAPSNGSKTAHSKVATGGGHANTQTS------SKRSSSGADGDYQLVQHEVLYSLSAQYEVLEFLGRGTFGQVV A_aegypti_AAEL003731-PA ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000020125 -----YQRCGLKRKSEELENN------SSVQIIEEHGP--SM-IQNG--GTSGATVATAATA-----TSTAT------SKNSGSNNEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVV M_domestica_ENSMODP00000029014 -----YQKCGLKRKSEEVDSN------GSVQIIEEHPP--LM-LQNR-------TVVGAAAT-----TTTVT------TKNSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVA M_domestica_ENSMODP00000017168 -----YQKCGLKRKSEEIENT------SSVQIIEEHPP---M-IQNN---ASGATVAT--AT-----TSTAT------SKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVV T_rubripes_ENSTRUP00000020840 -----YQRCGLKRKSEELDNN------SSVQIIEEHGP--PM-MQNG--AASGATVATVATT-----TSTAM------SKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVV D_rerio_ENSDARP00000062342 -----YQRCGLKRKSEELDNNNGSGSGSSVHVVEEQQPPAPM-IQNN--VQSGATVAT-ATA-----STTAT------SKNSGANSEGDYQLLQHEVLCSMTNTYEVLEFLGRGTFGQVV T_guttata_ENSTGUP00000005223 -----ARRCGLKRKSEELERQS-----STMQIVDELSILPAM-LQSG--VANPVTVV----------ATAAA------SKQGGTGGDGDYQLVQHEVLCSVKNTYEVLDFLGRGTFGQVV A_carolinensis_ENSACAP00000016703 -----YQKCGLKRKSEEIENT------SSVQIIEEHPP---M-IQNN---ASGATVAT--TT-----TSTAT------SKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVV C_familiaris_ENSCAFP00000006000 -----YQKCGLKRKSEEIENT------SSVQIIEEHPP---M-IQNN---ASGATVAT--AT-----TSTAT------SKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVV X_tropicalis_ENSXETP00000003569 -----YQKCGLKRKSEEVDSN------GSVQIIDERPP--LM-LQNR-------TVVGAAAT-----TTTVT------TKSSSSNGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVA G_gallus_ENSGALP00000020844 -----YQKCGLKRKSEEIENT------SSVQIIEEHPP---M-IQNN---ASGATVAT--AT-----TSTAT------SKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVV T_nigroviridis_ENSTNIP00000022455 -----Y-RCGLKRKSEELDNN------SSVQIIEEHGP--PV-MPNG--AASGATVATAATA-----TSTAM------SKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVV M_mulatta_ENSMMUP00000003337 -----YQKCGLKRKSEEIENT------SSVQIIEEHPP---M-IQNN---ASGATVAT--AT-----TSTAT------SKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVV P_troglodytes_ENSPTRP00000033846 -----YQKCGLKRKSEEIENT------SSVQIIEEHPP---M-IQNN---ASGATVAT--AT-----TSTAT------SKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVV H_sapiens_ENSP00000263551 -----YQKCGLKRKSEEIENT------SSVQIIEEHPP---M-IQNN---ASGATVAT--AT-----TSTAT------SKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVV R_norvegicus_ENSRNOP00000010384 -----YQKCGLKRKSEEIENT------SSVQIIEEHPP---M-IQNN---ASGATVAT--AT-----TSTAT------SKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVV M_musculus_ENSMUSP00000045457 -----YQKCGLKRKSEEIENT------SSVQIIEEHPP---M-IQNN---ASGATVAT--AT-----TSTAT------SKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVV T_guttata_ENSTGUP00000011747 -----YQKCGLKRKSEEIENT------SSVQIIEEHPP---M-IQNN---ASGATVAT--AT-----TSTAT------SKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVV E_caballus_ENSECAP00000007300 -----YQKCGLKRKSEEIENT------SSVQIIEEHPP---M-IQNN---ASGATVAT--AT-----TSTAT------SKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVV P_troglodytes_ENSPTRP00000006052 -----PQRCGLKRKSEELDNHS-----SAMQIVDELSILPAM-LQTN--MGNPVTVV----------TATTG------SKQNCTTGEGDYQLVQHEVLCSVKNTYEVLDFLGRGTFGQVV P_pygmaeus_ENSPPYP00000003875 -----PQRCGLKRKSEELDNHS-----SAMQIVDELSILPAM-LQTN--MGNPVTVV----------TATTG------SKQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVV G_gallus_ENSGALP00000002998 -----YQKCGLKRKSEEVDSN------GSVQIIEEHPP--LM-LQNR-------PAVGAAAT-----TTTVT------TKSSNSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVA G_gallus_ENSGALP00000019093 -----PQRCGLKRKSEELDNQS-----STMQIVDELSILPAM-LQTN--VGNPVTVV----------TTAAT------SKQTGTSGDGDYQLVQHEVLCSVKNTYEVLDFLGRGTFGQVV H_sapiens_ENSP00000304226 -----PQRCGLKRKSEELDNHS-----SAMQIVDELSILPAM-LQTN--MGNPVTVV----------TATTG------SKQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVV M_domestica_ENSMODP00000012226 -----TQRWGLKRKSKELENQS-----SAMQIVDELSILPAM-LQTN--MGNPVTVV----------TTTAA------SKQNCTSGEGDYQLVQHEVLCSLKNTYEVLDFLGRGTFGQVV A_carolinensis_ENSACAP00000002399 -----YQKCGLKRKSEEVDSN------GSVQIIEEHPP--LM-LQNR-------PAVGAAAT-----TTTVT------TKASSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVA E_caballus_ENSECAP00000013135 -----YQKCGLKRKSEEVDSN------GSVQIIEEHPP--LM-LQNR-------TVVGAAAT-----TTTVT------TKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVA C_familiaris_ENSCAFP00000013694 -----YQKCGLKRKSEEVDSN------GSVQIIEEHPP--LM-LQNR-------TVVGAAAT-----TTTVT------TKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVA C_familiaris_ENSCAFP00000010754 -----PQRCGLKRKSEELDNHS-----SAMQIVDELSILPAM-LQTN--MGNPVTVV----------TTTTG------TKQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVV E_caballus_ENSECAP00000018143 -----PPRCGLKRKSEELDHHG-----SAMQIVDELSVLPAM-LQTS--MGNPVTLV----------TATTG------TKPNCTSGEGDYQLVQHEVLCSLKNTYEVLDFLGRGTFGQVV H_sapiens_ENSP00000358574 -----YQKCGLKRKSEEVDSN------GSVQIIEEHPP--LM-LQNR-------TVVGAAAT-----TTTVT------TKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVA P_troglodytes_ENSPTRP00000001943 -----YQKCGLKRKSEEVDSN------GSVQIIEEHPP--LM-LQNR-------TVVGAAAT-----TTTVT------TKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVA B_taurus_ENSBTAP00000015051 -----YQKCGLKRKSEEVDSN------GSVQIIEEHPP--LM-LQNR-------TVVGAAAT-----TTTVT------TKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVA T_guttata_ENSTGUP00000001607 -----YQKCGLKRKSEEVDSN------GSVQIIEEHPP--LM-LQNR-------PAVGAAAT-----TTTVT------TKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVA M_musculus_ENSMUSP00000106754 -----PQRCGLKRKSEELENHS-----GAMQIVDELSILPAM-LQTN--MGNPVTVV----------TATTG------SKQNCTSGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVV B_taurus_ENSBTAP00000039475 -----PQRCGLKRKSEELDNHS-----SAMQIVDEVSILPAM-LQTN--MGNPVTVV----------TTTTG------TKQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVV M_musculus_ENSMUSP00000113998 -----YQKCGLKRKSEEVESN------GSVQIIEEHPP--LM-LQNR-------TVVGAAAT-----TTTVT------TKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVA A_carolinensis_ENSACAP00000003036 -----PQRCGLKRKSEDLENQS-----DTMQIVDELPILPAM-LQTN--LGNPVTVV-----------TTAT------SKPSSTSGDGDYQLVHHEVLCSVKSTYEVLDFLGRGTFGQVV R_norvegicus_ENSRNOP00000052927 -----YQKCGLKRKSEEVDSN------GSVQIIEEHPP--LM-LQNR-------TVVGAAAT-----TTTVT------TKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVA O_anatinus_ENSOANP00000023838 -----LQRCGLKRKSEELDRQS-----GAMQIVDELSILPAM-LPTN--VGTRVAVV----------TTTAA------SKPSGPGGEGDYQLVQHEVLCSAKNTYEVLDFLGRGTFGQVV T_rubripes_ENSTRUP00000027188 -----GHRHGQKRKMEEASEGSGSGC-GSVQILEELSAPAAN-YSTR-------TGGGGGGTGQSIPHSAPT------TKSSSSNGEGDYQLVQHEILCSVSSSYEVLEFLGRGTFGQVA R_norvegicus_ENSRNOP00000015775 -----PQRCGLKRKSEELDNHS-----GAMQIVDELSILPAM-LQTN--MGNPVTVV----------TATTG------SKQNCTSGEGDYQLVQHEVLCSVKNTYEVLDFLGRGTFGQVV D_rerio_ENSDARP00000083736 -----SHRCGLKRKSGELENLG-----STMQIVEDLSMLPAM-LQSN--VGNPPVAV----------PQAVGGGPAK-QGGGSGNGDGDYQLVQHEMLCSLKNTYEVLDFLGRGTFGQVV G_aculeatus_ENSGACP00000017894 -----YQRCGLKRKSEELDNN------SSVQIIEEHGP--AM-IQNG--AAGGVAVATVATA-----TSTAT------SKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVV T_rubripes_ENSTRUP00000010045 -----SQRCGLKRKSQELDNRG-----STMQIVEELSLLPAM-LQTTNGVGH-----------------GALG-----ATGGAGAGDGDYQVVQHEVLCSMKNTYEVLDFLGRGTFGQVV O_latipes_ENSORLP00000015420 ATQICEQKTGESGEQQQETRRV-----KAMQIVEEISALPSL--------PPPVTML----------QTSTE------NNADTVRGDGDYQLVQHEVLCSLKNSYEVLEFLGRGTFGQVV T_rubripes_ENSTRUP00000004224 --------------------------------------------------------------------------------------DGDYQLVQHEVLCSLKSSYEVLEFLGRGTFGQVV P_pygmaeus_ENSPPYP00000020253 -----YQKCGLKRKSEEIENT------SSVQIIEEHPP---M-IQNN---ASGATVAT--AT-----TSTAT------SKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVV G_aculeatus_ENSGACP00000021106 -----PQRCGLKRKSEELGNRG-----STMQIVEELTMLPAI-MQTTN-VGN-----------------AAAGGPSKAGAGGMGGGDGDYQVVQHEVLCSMKNTYEVLDFLGRGTFGQVV G_gorilla_ENSGGOP00000003977 -----YQKCGLKRKSEEIENT------SSVQIIEEHPP---M-IQNN---ASGATVAT--AT-----TSTAT------SKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVV G_aculeatus_ENSGACP00000000924 G----KPKPSSLSPEQAMKQFM-----SKMSSLEHHEV-----------FSYPEVYFVGPNAKKRSGVPGGA------NNGGYDDDQGSYIHVPHD---HIAYRYEVLKVIGKGSFGQVV G_aculeatus_ENSGACP00000000494 --------CGPLTPDQALRLYR-----SQLTTLEQAEI-----------HSYPEIFFVGPNAKKRPAVAGGN------NNCGYDDEQGGYTHVAHD---HLAYRYEFLKIIGKGSFGQVA A_gambiae_AGAP004833-PA PKESPEPPKDLDRQSKEPKTSA-----KENSKRPEWDMFAEQDIDSN--FDSPGTVVANKQA-----HENPA------LTDNWDDAEGYYRVRIGEIL---DNRYVVANYTGQGVFSTVV 730 740 750 760 770 780 790 800 810 820 830 840 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0072450 KCWKRG-TSEIVAIKILKNHPSYARQGQIEVSILSRLS-QENAD-EFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPILEQVLTALL--KLKQLGLIHADLKPE A_gambiae_AGAP007342-PA KCWKKG-TSDIVAIKILKNHPSYARQGQIEVSILSRLS-QENAD-EFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPILQQVLTALL--KLKQLGLIHADLKPE A_aegypti_AAEL003731-PA -------------------------------------------------------------------------------------------------VLTALL--KLKQLGLIHADLKPE O_latipes_ENSORLP00000020125 KCWKRG-TNEIVAIKILKNHPSYARQGQIEVSILARLS-TESAD-DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPVLQQVATALM--KLKSLGLIHADLKPE M_domestica_ENSMODP00000029014 KCWKRS-TKEIVAIKILKNHPSYARQGQIEVSILSRLS-SENAD-EYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPILQQVATALM--KLKSLGLIHADLKPE M_domestica_ENSMODP00000017168 KCWKRG-TNEIVAIKILKNHPSYARQGQIEVSILARLS-TESAD-DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPVLQQVATALM--KLKSLGLIHADLKPE T_rubripes_ENSTRUP00000020840 KCWKRG-TNEIVAIKILKNHPSYARQGQIEVSILARLS-TESAD-DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPVLQQVATALM--KLKSLGLIHADLKPE D_rerio_ENSDARP00000062342 KCWKRG-TSEIVAIKILKNHPSYARQGQIEVSILARLS-TESAD-DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPILQQVATALM--KLKSLGLIHADLKPE T_guttata_ENSTGUP00000005223 KCWKRG-TNEIVAIKILKNHPSYVRQGQIEVSILARLS-TENAD-EFNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQ-NKFSPLQLKVIRPILQQVATALK--KLKSLGLIHADLKPE A_carolinensis_ENSACAP00000016703 KCWKRG-TNEIVAIKILKNHPSYARQGQIEVSILARLS-TESAD-DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPILQQVATALM--KLKSLGLIHADLKPE C_familiaris_ENSCAFP00000006000 KCWKRG-TNEIVAIKILKNHPSYARQGQIEVSILARLS-TESAD-DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPVLQQVATALM--KLKSLGLIHADLKPE X_tropicalis_ENSXETP00000003569 KCWKRS-TKEIVAIKILKNHPSYARQGQIEVSILSRLS-SENAD-EYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPILQQVATALM--KLKSLGLIHADLKPE G_gallus_ENSGALP00000020844 KCWKRG-TNEIVAIKILKNHPSYARQGQIEVSILARLS-TESAD-DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPILQQVATALM--KLKSLGLIHADLKPE T_nigroviridis_ENSTNIP00000022455 KCWKRG-TNEIVAIKILKNHPSYARQGQIEVSILARLS-TESAD-DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPVLQQVATALM--KLKSLGLIHADLKPE M_mulatta_ENSMMUP00000003337 KCWKRG-TNEIVAIKILKNHPSYARQGQIEVSILARLS-TESAD-DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPVLQQVATALM--KLKSLGLIHADLKPE P_troglodytes_ENSPTRP00000033846 KCWKRG-TNEIVAIKILKNHPSYARQGQIEVSILARLS-TESAD-DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPVLQQVATALM--KLKSLGLIHADLKPE H_sapiens_ENSP00000263551 KCWKRG-TNEIVAIKILKNHPSYARQGQIEVSILARLS-TESAD-DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPVLQQVATALM--KLKSLGLIHADLKPE R_norvegicus_ENSRNOP00000010384 KCWKRG-TNEIVAIKILKNHPSYARQGQIEVSILARLS-TESAD-DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPVLQQVATALM--KLKSLGLIHADLKPE M_musculus_ENSMUSP00000045457 KCWKRG-TNEIVAIKILKNHPSYARQGQIEVSILARLS-TESAD-DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPVLQQVATALM--KLKSLGLIHADLKPE T_guttata_ENSTGUP00000011747 KCWKRG-TNEIVAIKILKNHPSYARQGQIEVSILARLS-TESAD-DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPILQQVATALM--KLKSLGLIHADLKPE E_caballus_ENSECAP00000007300 KCWKRG-TNEIVAIKILKNHPSYARQGQIEVSILARLS-TESAD-DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPVLQQVATALM--KLKSLGLIHADLKPE P_troglodytes_ENSPTRP00000006052 KCWKRG-TNEIVAIKILKNHPSYARQGQIEVSILARLS-TENAD-EYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKVIRPILQQVATALK--KLKSLGLIHADLKPE P_pygmaeus_ENSPPYP00000003875 KCWKRG-TNEIVAIKILKNHPSYARQGQIEVSILARLS-TENAD-EYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKVIRPILQQVATALK--KLKSLGLIHADLKPE G_gallus_ENSGALP00000002998 KCWKRS-TKEIVAIKILKNHPSYARQGQIEVSILSRLS-SENAD-EYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPILQQVATALM--KLKSLGLIHADLKPE G_gallus_ENSGALP00000019093 KCWKRG-TNEIVAIKILKNHPSYARQGQIEVSILARLS-TENAD-EFNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQ-NKFSPLQLKVIRPILQQVATALK--KLKSLGLIHADLKPE H_sapiens_ENSP00000304226 KCWKRG-TNEIVAIKILKNHPSYARQGQIEVSILARLS-TENAD-EYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKVIRPILQQVATALK--KLKSLGLIHADLKPE M_domestica_ENSMODP00000012226 KCWKRG-TSEIVAIKILKNHPSYARQGQIEVSILSRLS-TENAD-EFNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKVIRPILQQVATALK--KLKSLGLIHADLKPE A_carolinensis_ENSACAP00000002399 KCWKRS-TKEIVAIKILKNHPSYARQGQIEVSILSRLS-SENAD-EYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPILQQVATALM--KLKSLGLIHADLKPE E_caballus_ENSECAP00000013135 KCWKRS-TKEIVAIKILKNHPSYARQGQIEVSILSRLS-SENAD-EYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPILQQVATALM--KLKSLGLIHADLKPE C_familiaris_ENSCAFP00000013694 KCWKRS-TKEIVAIKILKNHPSYARQGQIEVSILSRLS-SENAD-EYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPILQQVATALM--KLKSLGLIHADLKPE C_familiaris_ENSCAFP00000010754 KCWKRG-TNEIVAIKILKNHPSYARQGQIEVSILARLS-TENAD-EYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKVIRPILQQVATALK--KLKSLGLIHADLKPE E_caballus_ENSECAP00000018143 KCWKRG-TNEIVAIKILKNHPSYARQGQIEVSILARLS-TENAD-EYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKVIRPILQQVATALK--KLKSLGLIHADLKPE H_sapiens_ENSP00000358574 KCWKRS-TKEIVAIKILKNHPSYARQGQIEVSILSRLS-SENAD-EYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPILQQVATALM--KLKSLGLIHADLKPE P_troglodytes_ENSPTRP00000001943 KCWKRS-TKEIVAIKILKNHPSYARQGQIEVSILSRLS-SENAD-EYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPILQQVATALM--KLKSLGLIHADLKPE B_taurus_ENSBTAP00000015051 KCWKRS-TKEIVAIKILKNHPSYARQGQIEVSILSRLS-SENAD-EYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPILQQVATALM--KLKSLGLIHADLKPE T_guttata_ENSTGUP00000001607 KCWKRS-TKEIVAIKILKNHPSYARQGQIEVSILSRLS-SENAD-EYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPILQQVATALM--KLKSLGLIHADLKPE M_musculus_ENSMUSP00000106754 KCWKRG-TNEIVAIKILKNHPSYARQGQIEVSILARLS-TENAD-EYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKVIRPVLQQVATALK--KLKSLGLIHADLKPE B_taurus_ENSBTAP00000039475 KCWKRG-TNEIVAIKILKNHPSYARQGQIEVSILARLS-TENAD-EYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKVIRPILQQVATALK--KLKSLGLIHADLKPE M_musculus_ENSMUSP00000113998 KCWKRS-TKEIVAIKILKNHPSYARQGQIEVSILSRLS-SENAD-EYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPILQQVATALM--KLKSLGLIHADLKPE A_carolinensis_ENSACAP00000003036 KCWKRE-TNEIVAIKILKNHPSYARQGQIEVSILARLS-TENAD-EFNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQ-NKFSPLQLKVIRPILQQVATALK--KLKSLGLIHADLKPE R_norvegicus_ENSRNOP00000052927 KCWKRS-TKEIVAIKILKNHPSYARQGQIEVSILSRLS-SENAD-EYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPILQQVATALM--KLKSLGLIHADLKPE O_anatinus_ENSOANP00000023838 KCWKSG-TNEIVAVKILKNHPSYARQGQIEVSILARLS-TENAD-EFNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKVIRPILQQVATALK--KLKSLGLIHADLKPE T_rubripes_ENSTRUP00000027188 KCWKRG-TNEIVAIKILKNHPSYARQGQIEVGILNRLS-AENAD-EYNFVRSYECFQHKGHTCLVFEMLEQNLYDFLKH-SKFSPLPLRHIRPILQQVATALM--KLKSLGLIHADLKPE R_norvegicus_ENSRNOP00000015775 KCWKRG-TNEIVAIKILKNHPSYARQGQIEVSILARLS-TENAD-EYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKVIRPVLQQVATALK--KLKSLGLIHADLKPE D_rerio_ENSDARP00000083736 KCWKRG-TKDIVAVKILKNHPSYARQGQIEVGILARLS-NENAD-EHNLVRAFECFQHRSHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKVIRPILQQVATALK--KLKGMGLIHADLKPE G_aculeatus_ENSGACP00000017894 KCWKRG-TNEIVAIKILKNHPSYARQGQIEVSILARLS-TESAD-DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPVLQQVASALM--KLKSLGLIHADLKPE T_rubripes_ENSTRUP00000010045 KCWNRG-TGEVVAVKILKNHPSYARQGQIEVSILARLS-GENAD-EHNLVRAFECFQHRSHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKVIRPVLQQVATALK--KLRSMGLIHADLKPE O_latipes_ENSORLP00000015420 KCWKRG-TNDVVAVKILKNHPSYARQGQIEVEILARLS-SENAE-EHNVVRALECFQHRSHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKVIRPILQQVATALK--KLKSLGLIHADLKPE T_rubripes_ENSTRUP00000004224 KCWKRG-TNEVVAIKILKNHPSYARQGQIEVEILARLS-GENAD-EHNVVRALECFQHRSHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKIIRPILQQVATALK--KLKSLGLIHADLKPE P_pygmaeus_ENSPPYP00000020253 KCWKRG-TNEIVAIKILKNHPSYARQGQIEVSILARLS-TESAD-DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPVLQQVATALM--KLKSLGLIHADLKPE G_aculeatus_ENSGACP00000021106 KCWKRG-TGEVVAVKILKNHPSYARQGQIEVGILARLS-AENAD-EHNLVRAFECFQHRSHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKVIRPVLQQVATALKAPRTSSLGTIGAIVALQ G_gorilla_ENSGGOP00000003977 KCWKRG-TNEIVAIKILKNHPSYAXQGQIEVSILARLS-TESAD-DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPVLQQVATALM--KLKSLGLIHADLKPE G_aculeatus_ENSGACP00000000924 KAFDHR-SQTHLALKMVRNEKRFHRQAAEEIRILEHLR-KQDKDSSMNVIHMLENFTFRNHICMTFELLSMNLYELIKK-NKFQGFSLPLVRKFAHSILQCLD--SLHKNRIIHCDLKPE G_aculeatus_ENSGACP00000000494 KVYDHK-LQQHLALKMVRNEKRFHRQAQEEIRILEHLR-KQDRNGTMNVVHMLENFTFRNHICMTFELLSMNLYELIKR-NKFQGFSLPLVRKFAHSILQCLE--ALSKHRIIHCDLKPE A_gambiae_AGAP004833-PA KARDQARGNAFVAVKIIRNNEIMHKTGLRELEILKKLNDADPSD-RYHCLRLYRHFFHKQHLCMVLEPLSMNLREVLKKYGKNVGLHIKAVRSYTQQLLLALK--LLKKTGILHADIKPD 850 860 870 880 890 900 910 920 930 940 950 960 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0072450 NIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTYPF A_gambiae_AGAP007342-PA NIMLVDPNRQPYRVKVIDFGSASHVSKTVCNTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEYDQIRYISQTQGLPTEHMLNSASKTAKFFYRDVDSTYPF A_aegypti_AAEL003731-PA NIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEYDQIRYISQTQGLPTEHMLNSASKTAKFFYRDVDSTYPF O_latipes_ENSORLP00000020125 NIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPDSTYPL M_domestica_ENSMODP00000029014 NIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTSRFFNRDPNLGYPL M_domestica_ENSMODP00000017168 NIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPL T_rubripes_ENSTRUP00000020840 NIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPDSTYPL D_rerio_ENSDARP00000062342 NIMLVDPARQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPDSTYPL T_guttata_ENSTGUP00000005223 NIMLVDPVRQPYRVKVIDFGSASHVSKTICSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLSMGTKTARFFCRETDAPYSS A_carolinensis_ENSACAP00000016703 NIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPL C_familiaris_ENSCAFP00000006000 NIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPL X_tropicalis_ENSXETP00000003569 NIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTSRFFNRDPDLGYPL G_gallus_ENSGALP00000020844 NIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPL T_nigroviridis_ENSTNIP00000022455 NIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPDSTYPL M_mulatta_ENSMMUP00000003337 NIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPL P_troglodytes_ENSPTRP00000033846 NIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPL H_sapiens_ENSP00000263551 NIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPL R_norvegicus_ENSRNOP00000010384 NIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPL M_musculus_ENSMUSP00000045457 NIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPL T_guttata_ENSTGUP00000011747 NIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPL E_caballus_ENSECAP00000007300 NIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPL P_troglodytes_ENSPTRP00000006052 NIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSG P_pygmaeus_ENSPPYP00000003875 NIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSG G_gallus_ENSGALP00000002998 NIMLVDPARQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTSRFFNRDPNLGYPL G_gallus_ENSGALP00000019093 NIMLVDPVRQPYRVKVIDFGSASHVSKTICSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLSMGTKTARFFCRETDAPYSS H_sapiens_ENSP00000304226 NIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSG M_domestica_ENSMODP00000012226 NIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCREIDISHSG A_carolinensis_ENSACAP00000002399 NIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTSRFFNRDPNLGYPL E_caballus_ENSECAP00000013135 NIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPL C_familiaris_ENSCAFP00000013694 NIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPL C_familiaris_ENSCAFP00000010754 NIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCRETEISHSG E_caballus_ENSECAP00000018143 NIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCRETDISHSG H_sapiens_ENSP00000358574 NIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPL P_troglodytes_ENSPTRP00000001943 NIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPL B_taurus_ENSBTAP00000015051 NIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPL T_guttata_ENSTGUP00000001607 NIMLVDPARQPYRV-VIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTSRFFNRDPNLGYPL M_musculus_ENSMUSP00000106754 NIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCRETDMSHSG B_taurus_ENSBTAP00000039475 NIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCRETDLSHSG M_musculus_ENSMUSP00000113998 NIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPL A_carolinensis_ENSACAP00000003036 NIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPAEQLLNIGTKTTRFFCKETDAPYSS R_norvegicus_ENSRNOP00000052927 NIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-RQASPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPL O_anatinus_ENSOANP00000023838 NIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCRETDTPHSG T_rubripes_ENSTRUP00000027188 NIMLVDPIRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTVRFFNRGPDSSYPL R_norvegicus_ENSRNOP00000015775 NIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCRETDMSHSG D_rerio_ENSDARP00000083736 NIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEFDQIRYISQTQGLPGEHLLNVGTKTSRFFCRESDSPYAT G_aculeatus_ENSGACP00000017894 NIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-S--SSEICCGGPGIHQYPVWSQTQVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPDSTYPL T_rubripes_ENSTRUP00000010045 NIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEHLLNVGTKTARFFCKESDSPYAA O_latipes_ENSORLP00000015420 NIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYSR--APEIILGLPFSEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPAEKLLNKGTKTSRFFTKESDSPYAS T_rubripes_ENSTRUP00000004224 NIMLVDPNRQPYRVKVIDFGSASHVSKAVRSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISRTQGLPAEHLLNKGTKTSRFFSKESDSPNAS P_pygmaeus_ENSPPYP00000020253 NIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPL G_aculeatus_ENSGACP00000021106 NVLPLDKTTRPVEVLVLKVNSHLRVSQHVVSTSLQSRFH-R--APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEHLLNSGTKKTRFFCKESDSPYAA G_gorilla_ENSGGOP00000003977 NIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY-R--APEIILGLPXCEAIDMWSLGCVIAELFLGWPLYPGASEYDQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX G_aculeatus_ENSGACP00000000924 NILLKQQGRS--GIKVIDFGSSCYEHQRV-YTYIQSRFY-R--APEVILGSRYGMPIDMWSLGCILAELLTGYPLLPGEDEADQLACIIELLGMPSQKLLDASKRAKNFVSSKGYPRYCT G_aculeatus_ENSGACP00000000494 NILLKQQGRS--GIKVIDFGSSCFEHQRV-YTYIQSRFY-R--APEVILGSRYGLPIDMWSFGCILAELLTGYPLFPGEDEGDQLACVMELLGMPPQKVLEQAKRAKNFINSKGHPRYCG A_gambiae_AGAP004833-PA NILVNE---NNLVLKLCDFGSASSITDNEITPYLVSRFY-R--APEIILGLTYDYGIDMWSAGCSIYELYTGKILFSGQSNNQMLKCFMDLKGKIPNKLIRKGQFKDQHFDQNCNFL--- 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0072450 WRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRR--EFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEVCRRGD----FHTV A_gambiae_AGAP007342-PA WRLKTPEEHEAETNNKSKEARKYIFNCLDDIGQVNVPTDIEGGQLLAEKTDRR--EFIDLLKRMLTIDQERRITPGEALNHSFATLAHLVDYAHCNNVKASVQMMEVCRRTDSM--IHTV A_aegypti_AAEL003731-PA WRLKTPEEHEAETNNKSKEARKYIFNCLDDIGQVNVPTDIEGGQLLAEKTDRR--EFIDLLKRMLTIDQERRITPGEALNHPFTTLAHLVDYAHCNNVKASVQMMEVCRRTDSM--IHTV O_latipes_ENSORLP00000020125 WRLKTPEDHEAETGIKSKEARKYIFNCLDDMAQVNMTSDLEGSDLLAEKADRR--EFIDLLTKMLTIDADKRITPIETLNHPFVTMSHLLDFPHSTHVKSCFQNMEICKRRVNM--YDTV M_domestica_ENSMODP00000029014 WRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRR--EYIDLLKKMLTIDADKRITPLKTLNHSFVTMTHLLDFPHSNHVKSCFQNMEICKRRGHM--YDTV M_domestica_ENSMODP00000017168 WRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRR--EFIDLLKKMLTIDADKRVTPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNM--YDTV T_rubripes_ENSTRUP00000020840 WRLKTPEDHEGETGIKSKEARKYIFNCLDDMAQVNMTSDLEGSEMLAEKADRR--EFIDLLTKMLTIDADKRITPIETLNHPFVTMSHLLDFPHSAHVKSCFQNMEICKRRVNM--YDTV D_rerio_ENSDARP00000062342 WRLKTPEDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLAEKADRR--EFIDLLTKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNM--YDTV T_guttata_ENSTGUP00000005223 WRLKTLEEHEAETGMKSKEARKYIFNSLDDIVHVNMVMDLEGSDLLAEKADRR--EFVSLLKKMLLIDADLRITPAETLNHSFVTMKHLLDFPHSNQVKSCFHIMDICKCRSNL--YDLS A_carolinensis_ENSACAP00000016703 WRLKTPDDHETETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRR--EFIDLLKKMLTIDTDKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNM--YDTV C_familiaris_ENSCAFP00000006000 WRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRR--EFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNM--YDTV X_tropicalis_ENSXETP00000003569 WRLKAPDEHEMETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRR--EYIDLLKKMLTIDADKRITPLKTLNHPFVTMTHLLDFPHSNHVKSCFQNMEICKRRSNM--YDTV G_gallus_ENSGALP00000020844 WRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRR--EFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNM--YDTV T_nigroviridis_ENSTNIP00000022455 WRLKTPEDHEGETGIKSKEARKYIFNCLDDMAQVNMASDLEGSDMLAEKADRR--EFIDLLTKMLTIDADKRITPIETLNHPFVTMSHLLDFPHSTHVKSCFQNMEICKRRVNV--YDTV M_mulatta_ENSMMUP00000003337 WRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRR--EFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNM--YDTV P_troglodytes_ENSPTRP00000033846 WRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRR--EFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNM--YDTV H_sapiens_ENSP00000263551 WRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRR--EFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNM--YDTV R_norvegicus_ENSRNOP00000010384 WRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRR--EFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNM--YDTV M_musculus_ENSMUSP00000045457 WRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRR--EFIDLLKKMLTIDADKRVTPIETLNHPFVTMTHLLDFPHSAHVKSCFQNMEICKRRVNM--YDTV T_guttata_ENSTGUP00000011747 WRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRR--EFIDLLKKMLTIDADKRITPIETLSHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNM--YDTV E_caballus_ENSECAP00000007300 WRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRR--EFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNM--YDTV P_troglodytes_ENSPTRP00000006052 WRLKTLEEHEAETGMKSKEARKYIFNSLDDIAHVNTVMDLEGSDLLAEKADRR--EFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKSHLNS--CDTN P_pygmaeus_ENSPPYP00000003875 WRLKTLEEHEAETGMKSKEARKYIFNSLDDIAHVNTVMDLEGSDLLAEKADRR--EFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKSHLNS--CDTN G_gallus_ENSGALP00000002998 WRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRR--EYIDLLKKMLTIDADKRITPLKTLNHPFVTMTHLLDFPHSNHVKSCFQNMEICKRRVNM--YDTV G_gallus_ENSGALP00000019093 WRLKTLEEHEAETGMKSKEARKYIFNSLDDIVHVNMVMDLEGSDLLAEKADRR--EFVSLLKKMLLIDADLRITPAETLNHSFVTMKHLLDFPHSNQVKSCFHIMDVCKCRSNL--YDLS H_sapiens_ENSP00000304226 WRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRR--EFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKSHLNS--CDTN M_domestica_ENSMODP00000012226 WRLKTLEEHEAETGMKSKEARKYIFNSLDDIVHVNTVMDLEGSDLLAEKADRR--EFVSLLKKMLLIDADLRITPVETLNHPFVNMKHLLDFPHSNHVKSCFHIMDVCKSHSNS--YDTN A_carolinensis_ENSACAP00000002399 WRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRR--EYIDLLKKMLTIDADKRVTPLKTLNHPFVTMNHLLDFPHSNHVKSCFQNMEICKRRVNM--YDTV E_caballus_ENSECAP00000013135 WRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRR--EYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHM--YDTV C_familiaris_ENSCAFP00000013694 WRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRR--EYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHM--YDTV C_familiaris_ENSCAFP00000010754 WRLKTLEEHEAETGMKSKEARKYIFNSLDDIVHVNTVMDLEGSDLLAEKADRR--EFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKSHPNS--CDTN E_caballus_ENSECAP00000018143 WRLKTLEEHEAETGMKSKEARKYIFSSLDDIVHVNTVMDLEGSDLLAEKADRR--EFVGLLKKMLLIDADFRITPAETLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKSHPNL--CDTN H_sapiens_ENSP00000358574 WRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRR--EYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHM--YDTV P_troglodytes_ENSPTRP00000001943 WRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRR--EYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHM--YDTV B_taurus_ENSBTAP00000015051 WRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRR--EYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHM--YDTV T_guttata_ENSTGUP00000001607 WRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRR--EYIDLLKKMLTIDADKRITPLKTLNHSFVTMAHLLDFPHSNHVKSCFQNMEICKRRVNM--YDTV M_musculus_ENSMUSP00000106754 WRLKTLEEHEAETGMKSKEARKYIFNSLDDIVHVNTVMDLEGGDLLAEKADRR--EFVNLLKKMLLIDADLRITPIETLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKS-PSS--CETN B_taurus_ENSBTAP00000039475 WRLKTLEEHEAETGMKSKEARKYIFNSLDDIVHVNTVMDLEGSDLLAEKADRR--EFVGLLKKMLLIDADLRITPAETLNHAFVNMKHLLDFPHSNHVKSCFHIMDICKSHPNS--CDAN M_musculus_ENSMUSP00000113998 WRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRR--EYIDLLKKMLTIDADKRITPLKTLNHQFVTMSHLLDFPHSSHVKSCFQNMEICKRRVHM--YDTV A_carolinensis_ENSACAP00000003036 WRLKTLEEHEGETGMKSKEARKYIFNSLDEIVHVNMVMDLEESDQLAEKADRR--EFVSLLRKMLLIDADLRITPVDTLNHPFVTMKHLLDFPHSNQVKSCFHIMDVCKYRSNS--YDTN R_norvegicus_ENSRNOP00000052927 WRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRR--EYIDLLKKMLTIDADKRVTPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHM--YDTV O_anatinus_ENSOANP00000023838 WRLKTLEEHEAETGMKSKEARKYIFSSLDDIVHVNMVMDLEGSDLLAEKADRR--EFVSLLKKMLMIDAELRITPAETLNHAFVNMKHLLDFPHSSHVKSCFHIMDVCKSHSNS--HDIN T_rubripes_ENSTRUP00000027188 WRLKTPAEHEMEMGIKSKEARKYIFNCLDDMMQVNLSSHLEGTDMLAEKADRR--EFIDLLKRMLRLDADKRITPTKTLGHPFVTMSHLVDYPHSSHVKSCFQNMEICKRRSS---YDS- R_norvegicus_ENSRNOP00000015775 WRLKTLEEHEAETGMKSKEARKYIFNSLDDIVHVNTVMDLEGSDLLAEKADRR--EFVSLLKKMLLIDADLRITPIETLNHPFVSMKHLLDFPHSSHVKSCFHIMDICKS-PSS--CETN D_rerio_ENSDARP00000083736 WRLKSTEEHETETGLKSKEARKYIFSCLDDIAHVNLVMNLEGCDLLAEKVDRA--EFVALLKKMLLIDAEERIAPSDALSHPFVTMQHLLDFPHSNHVKSCFHIMDVCCSRPGS--YESH G_aculeatus_ENSGACP00000017894 WRLKTPEDHEGETGIKSKEARKYIFNCLDDMAQVNMTSELEGSDMLAEKADRR--EFIDLLTKMLTIDADKRITPIETLNHPFVTMSHLLDFPHSTQVKSCFQNMEICKRRVNM--YDAV T_rubripes_ENSTRUP00000010045 WRLKSTDEHETETGMKSKEARKYIFSCLDDIAHVNLVMNMEGSDLLAEKADRR--EFVGLLKKMLLIDAEERIAPVEALGHPFVTMQHLLDFPHSNHVKSCFHIMDICWSRTSA--YEVT O_latipes_ENSORLP00000015420 WRLKTTEEHEKETGLKSKEARKYIFSCLDDIAHVNLVLSPDNGDMQSEKEDRR--EFVSLLKSMLTIDAEDRTVPSSVLNHPFLTMTHLLDFPHSHHVQSSFRIMDMCHSRPSNAIFDAL T_rubripes_ENSTRUP00000004224 WRLKTTEEHEKETGLKSKEARKYVFSCLDDIAHVNLVLSLDPSDMQAEKADRR--EFVSLLKSMLLISAEDRTDPSSVLNHPFLTMTHLLDYPHSHLVQACFQIMDVCHSWSSNAVFDAL P_pygmaeus_ENSPPYP00000020253 WRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQ----------------------------------------------------------------VKSCFQNMEICKRRVNM--YDTV G_aculeatus_ENSGACP00000021106 WRLKSTDEHETETGMKSKEARKYIFSCLDDIAHVNLVMNLEGCDLLVEKADRR--EFVGLLKKMLLIDAEERITPAEALSHPFVTMQHLLDFPHSNHVKSCFHIMDVCWTRPSA--YEAA G_gorilla_ENSGGOP00000003977 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVNMTTDLEGSDMLVEKADRR--EFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNM--YDTV G_aculeatus_ENSGACP00000000924 -VTTLPDGTAMLNAGRSRRGK------------VRGTPGSKDWSVALKGADDP--LFLDFLKQCLEWDPALRMTPSQALRHPWLRRR--LPKPPTG----------------------TT G_aculeatus_ENSGACP00000000494 -ANTLPTGATVLTGSRSRRGK------------MRGPPGSKEWSAALKGCEDP--TFTDFIKKCLDWDPSSRLTPTQALRHPWLYRR--LPKPLPG-----------------------A A_gambiae_AGAP004833-PA -------SHEID---KITEREKVVVVSMIKPTR-DLQQELIAGQNLPDDQIRKVSQLKDLLDKVFALDPAKRISLNHALAHPFIQDK--------------------------------- 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0072450 QP-ASTLVTNF-VPSSTEN-MTFTINNQLTSQVQRLVRDG-------------------------RPLAYEGLYQIYNGRSV-------------ARQYPQTRTDSFQHQLVSNILCPPS A_gambiae_AGAP007342-PA QPTTATLVTNF-VPNTTEN-MTITFNN----QVQRIVRER-------------------------APTYDNHLYQIYGGRNV-------------GRQYSNARPDAFQHQLVSSILCPPG A_aegypti_AAEL003731-PA QPTTATLVTNF-VPNATEN-MTITFNN----QVQRIVRER-------------------------GPTYDNHLYQIYRGRNV-------------GGQYSNGRPDAFQHQLVSSILCPPG O_latipes_ENSORLP00000020125 NQSKTPFITHV-APSTSTN-LTMTFNN----QLNTVHSQA--TNLTSSSST-NNATLSFASPDVSVLNYQSALYQPSA-ASMAAVAQRSMPLQPGAPQLCAARPDPFQQAL---IVCPPG M_domestica_ENSMODP00000029014 KQIKSPFTTHV-APNTSTN-LTMTFSN----HLNTGH-------------------------------IRSALYPSSA-APVAGVAQQSVSLQPGTTQIC-TQTDPFQQTF---IVCPPT M_domestica_ENSMODP00000017168 NQSKTPFITHV-APSTSTN-LTMTFNN----QLNTVHNQA--TNL-APTST--SATISLANPEVSILNYQSTLYQPSA-ASMAAVAQRSMPLQTGTAQIC-ARPDPFQQAL---IVCPPG T_rubripes_ENSTRUP00000020840 NQSKTPFITHV-APSTSTN-LTMTFNN----QLNTVHSQA--TNL-APSST-NSTTLSFASPDVSILNYQSALYQPAA-ASMAAVAQRSMPLQPGAPQLCAARPDPFQQAL---IVCPPG D_rerio_ENSDARP00000062342 NQSKTPFITHV-APSTSTN-LTMTFNN----QLNTVHSQ-------APSST--SATLSLTNPDVSILNYQSALYQPSA-APMAAVAPRTMPLQPGAPQLCAARPDPFQQAL---IVCPPG T_guttata_ENSTGUP00000005223 NCNKTSLMRSV-ASGSAAN-LTASF-A----KIGPVRSQA------------------------------------LT-ASAHSVLHQGIPLQAGTAQFG--CSDVFQQAL---IICPPA A_carolinensis_ENSACAP00000016703 NQSKTPFITHV-APSTSTN-LTMTFNN----QLNTVHN------------------------------------QPSA-ASMAAVAQRSVPLQTGTAQIC-ARPDPFQQAL---IVCPPG C_familiaris_ENSCAFP00000006000 NQSKTPFITHV-APSTSTN-LTMTFNN----QLNTVHNQSAMAST-APTST--SATISLANPEVSILNYQSALYQPSA-ASMAAVAQRSMPLQTGTAQIC-ARPDPFQQAL---IVCPPG X_tropicalis_ENSXETP00000003569 NQIKSPFTTHV-APNTSTN-LTMSFNN----QLNSVHNQA--SVL-ASSST-AAATLSLANSDVSLLNYQSALYPPAA-GPVTGVTQQSVSLQPGTTQLC-TQTDPFQQTF---IVCPPA G_gallus_ENSGALP00000020844 NQSKTPFITHV-APSTSTN-LTMTFNN----QLNTVHNQT--TNL-APTSS--SATISLANPEVSILNYQSALYQPSA-ASMAAVAQRSMPLQTGTAQIC-ARPDPFQQAL---IVCPPG T_nigroviridis_ENSTNIP00000022455 NQSKTPFITHV-APSTSTN-LTMTFNN----QLNTVHSQA--TNL-APSST-NSTTLSFASPDVSILNYQSALYQPSA-TSMAAMAQRSMPLQPGAPQLCAARPDPFQQAL---IVCPPG M_mulatta_ENSMMUP00000003337 NQSKTPFITHV-APSTSTN-LTMTFNN----QLTTVHNQ-------APSST--SATVSLANPEVSILNYPSTLYQPSA-ASMAAVAQRSMPLQTGTAQIC-ARPDPFQQAL---IVCPPG P_troglodytes_ENSPTRP00000033846 NQSKTPFITHV-APSTSTN-LTMTFNN----QLTTVHNQ-------APSST--SATISLANPEVSILNYPSTLYQPSA-ASMAAVAQRSMPLQTGTAQIC-ARPDPFQQAL---IVCPPG H_sapiens_ENSP00000263551 NQSKTPFITHV-APSTSTN-LTMTFNN----QLTTVHNQ-------APSST--SATISLANPEVSILNYPSTLYQPSA-ASMAAVAQRSMPLQTGTAQIC-ARPDPFQQAL---IVCPPG R_norvegicus_ENSRNOP00000010384 NQSKTPFITHV-APSTSTN-LTMTFNN----QLTTVHNQ-------APTST--SATLSLANPEVSILNYQSTLYQPSA-ASMAAVAQRSMPLQTGTAQIC-ARPDPFQQAL---IVCPPG M_musculus_ENSMUSP00000045457 NQSKTPFITHV-APSTSTN-LTMTFNN----QLTTVHNQ-------APTTS--SATLSLANPEVSILNYQSALYQPSA-ASMAAVAPRSMPLQTGTAQIC-ARPDPFQQAL---IVCPPG T_guttata_ENSTGUP00000011747 NQSKTPFITHV-APSTSTN-LTMTFNN----QLNTVHNQT--TNL-APTSS--SATISLANPEVSILNYQSALYQPSA-ASMAAVAQRSMPLQTGTAQIC-ARPDPLQQAL---IVCPPG E_caballus_ENSECAP00000007300 NQSKTPFITHV-APSTSTN-LTMTFNN----QLNTVHNQS--EQI-APTST--SATISLANPEVSILNYHSALYQPSA-ASMAAVAQRSMPLQTGAAQIC-ARPDPFQQAL---IVCPPG P_troglodytes_ENSPTRP00000006052 NHNKTSLLRPV-ASSSTAT-LTANF-T----KIGTLRSQA------------------------------------LT-TSAHSVVHHGIPLQAGTAQFG--CGDAFQQTL---IICPPA P_pygmaeus_ENSPPYP00000003875 NHNKTSLLRPV-ASSSTAT-LTANF-T----KIGTLRSQA------------------------------------LT-TSAHSVVHHGIPLQAGTAQFG--CGDAFQQTL---IICPPA G_gallus_ENSGALP00000002998 NQIKSPFTTHV-APNTSTN-LTMSFNN----QLNTVHNQA--SVL-ASNST-AAATLSLANSDVSLLNYQSALYPSSA-APVAGVAQQSVSLQPGTTQIC-TQTDPFQQTF---IVCPPA G_gallus_ENSGALP00000019093 NRNKTSLMRPV-ASGSAAN-LTASF-T----KIGPLRSQA------------------------------------LT-ASAHSVLHQGIPLQAGTAQFG--CSDIFQQTL---IICPPT H_sapiens_ENSP00000304226 NHNKTSLLRPV-ASSSTAT-LTANF-T----KIGTLRSQA------------------------------------LT-TSAHSVVHHGIPLQAGTAQFG--CGDAFQQTL---IICPPA M_domestica_ENSMODP00000012226 NRNKTSLMRPV-ASGSTAS-LTTNF-T----KIGTLRSQA------------------------------------LT-TSAHSVMHHGVPVQTGTA----------QQTL---IICPPS A_carolinensis_ENSACAP00000002399 NQIKSPFTTHV-APNTSTN-LTMSFNN----QLNTVHHQA--SVL-ASNST-AAATLSLANSDVSLLNYQSALYPSSA-APVAGVAQQSVSLQPGTTQIC-TQTDPFQQTF---IVCPPA E_caballus_ENSECAP00000013135 SQIKSPFTTHV--PNTSTN-LTMSFSN----QLNTVHNQA--SVL-ASSSTAAAATLSLANSDVSLLNYQSALYPSSA-APVPGVAQQGVSLQPGTTQIC-TQTDPFQQTF---IVCPPA C_familiaris_ENSCAFP00000013694 SQIKSPFTTHV-APNTSTN-LTMSFSN----QLNTVHNQA--SVL-ASSSTAAAATLSLANSDVSLLNYQSALYPSSA-APVPGVAQQGVSLQPGTTQIC-TQTDPFQQTF---IVCPPA C_familiaris_ENSCAFP00000010754 NHNKTSLLRPV-ASGNTAN-LTANF-T----KIGTLRNQA------------------------------------LT-TSAHSVVHHGIPLQAGTAHFG--CGDAFQQTL---IICPPA E_caballus_ENSECAP00000018143 NHNKASLLRPV-ASSSTAN-LTANF-T----KIGTLRNQA------------------------------------LT-TSAHSVVHHGIPLQAGTAHFG--CGDAFHQTL---IICPPA H_sapiens_ENSP00000358574 SQIKSPFTTHV-APNTSTN-LTMSFSN----QLNTVHNQA--SVL-ASSSTAAAATLSLANSDVSLLNYQSALYPSSA-APVPGVAQQGVSLQPGTTQIC-TQTDPFQQTF---IVCPPA P_troglodytes_ENSPTRP00000001943 SQIKSPFTTHV-APNTSTN-LTMSFSN----QLNTVHNQA--SVL-ASSSTAAAATLSLANSDVSLLNYQSALYPSSA-APVPGVAQQGVSLQPGTTQIC-TQTDPFQQTF---IVCPPA B_taurus_ENSBTAP00000015051 SQIKSPFTTHV-APNTSTN-LTMSFSN----QLNTVHNQA--SVL-ASSSTAAAATLSLANSDVSLLNYQSALYPSSA-APVPGVAQQGVSLQPGTTQIC-TQTDPFQQTF---IVCPPA T_guttata_ENSTGUP00000001607 NQIKSPFTTHV-APNTSTN-LTMSFNN----QLNTVHNQA--SVL-ASNST-AAATLSLANSDVSLLNYQSALYPSSA-APVAGVAQQSVSLQPGTTQIC-TQTDPFQQTF---IVCPPA M_musculus_ENSMUSP00000106754 NHSKMSLLRPV-ASNGTAA-LAANF-T----KVGTLRSQA------------------------------------LT-TSAHSVVHHGIPLQAGTAQFG--CGDAFHQTL---IICPPA B_taurus_ENSBTAP00000039475 NHNKTSLLRPV-APSSTTN-LAANF-T----KIGTLRSQA------------------------------------LT-TSAHSVVHHGIPLQAGTAHFG--CGDAFQQTL---IICPPA M_musculus_ENSMUSP00000113998 SQIKSPFTTHV-APNTSTN-LTMSFSN----QLNTVHNQA--SVL-ASSSTAAAATLSLANSDVSLLNYQSALYPSSA-APVPGVAQQGVSLQPGTTQIC-TQTDPFQQTF---IVCPPA A_carolinensis_ENSACAP00000003036 NRNKTAHLRPV-ASSNAPS-LTANF-A----KMGAVRNHA------------------------------------LA-ASTHSVLPHGIPLQAGAAQFG--CSDAFHQTL---IICPPA R_norvegicus_ENSRNOP00000052927 SQIKSPFTTHV-APSTSTN-LTMSFSN----QLSTVHNQA--SVL-ASSSTAAAATLSLANSDVSLLNYQSALYPPSA-APVPGVAQQGVSLQPGTTQIC-TQTDPFQQTF---IVCPPA O_anatinus_ENSOANP00000023838 NRNKTSLLRPV-ASGSAAN-LTANF-S----KIGTLRSQA------------------------------------LS-ASAH-VMHHGIPLQAGTAQFG--CNDAFQQTL---IICPPA T_rubripes_ENSTRUP00000027188 --SKSLYSTSA-VPSAAGN-LTVTFSS----QLNQ-HNQE---VPLAHKGTAPRRGVPSAGGAVPLLNYQPALYQQAT-INIPGLTQQSVPIPTRPTGLC-SQTEPFQQTL---IVCPPS R_norvegicus_ENSRNOP00000015775 NHSKMSLLRPV-ASNGTAA-LAANF-T----KVGTLRSQA------------------------------------LT-TSAHSVVHHGIPLQAGTAQFG--CGDAFHQTL---IICPPA D_rerio_ENSDARP00000083736 SRTKAQFVRTV-PSTGAASNLTLPF-C----KVTGIHTQA------------------------------------LA-SSAPTVMHPGIPLQTGSAQFG----DSFQQAL---ILCPPT G_aculeatus_ENSGACP00000017894 NQSKTPFYHLTWPPSTSTN-LTM-FNN----QLNTVHSQ-------VPSST-NNATLSFASPDVSILNYQSALYQPSA-AAMAAVAQRSMPLQPGPPQLCAARPDPFQQAL---IVCPPG T_rubripes_ENSTRUP00000010045 NRTKGPFVRPV-TTTSAAT-VNHPF-N----KVAGVHAQG------------------------------------LA-PSAPTVMHPGIPLQTGTGPFG--CSDSFQQAL---ILCPPT O_latipes_ENSORLP00000015420 NQNTIHFSRPP-LAPASSS-VTLGY-S----NIL-VHTQN------------------------------------STMQSAQSVLHPGIALTAGNGQFG--CSDSFPPAL---LLCPPA T_rubripes_ENSTRUP00000004224 NQNTIHFSRPP-LAPAASSGLPLAY-S----NIP-IHNQN------------------------------------KT-QSASSVLHPGIALAPGNGQFG--CSDSFPSAL---LLCPPT P_pygmaeus_ENSPPYP00000020253 NQSKTPFITHV-APSTSTN-LTMTFNN----QLTTVHNQ-------APSST--SATISLANPEVSILNYPSTLYQPSA-ASMAAVAQRSMPLQTGTAQIC-ARPDPFQQAL---IVCPPG G_aculeatus_ENSGACP00000021106 NRNKGPFIRTV-ATTAAAS-VNHPF-S----KITGVHPQG------------------------------------LA-PSAQSVMHPGIPLQTGSGQFG--CSDSFPQAL---ILCPPT G_gorilla_ENSGGOP00000003977 NQSKTPFITHV-APSTSTN-LTMTFNN----QLTTVHNQ-------APSST--SATISLANPEVSILNYPSTLYQPSA-ASMAAVAQRSMPLQTGTAQIC-ARPDPFQQAL---IVCPPG G_aculeatus_ENSGACP00000000924 PGDKTSSSKRG-AATTADG-AITSL-S----KLATTSSTT-------------------------------------------------------------ASSSKTRTNL--------- G_aculeatus_ENSGACP00000000494 EKSYGAPVKRL-PEHHSTS-FPSIL-A----KGGPGLSST-------------------------------------------------------------AVNNKLRSNM--------- A_gambiae_AGAP004833-PA ------------------------------------------------------------------------------------------------------------------------ 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0072450 -YQ---------TM-PSPTKHV---VVGSATMQPPLQVPPQQYVNVPVPVSM-----------------------------VEPTSGQRMLLTNRVQASGVAWPQTGRQMALVPSWPQQA A_gambiae_AGAP007342-PA -YQ---------TM-PSPTKHV---VVGGTSMQPPLQVPPQQYVNVPVPVSM-----------------------------VEPSSGQRMLLTNAVQPN-VAWPQSGRQVAIVPSWSQQP A_aegypti_AAEL003731-PA -YQ---------TM-PSPTKHV---VVGGTSMQPPLQVPPQQYVNVPVPVSM-----------------------------VEPSSGQRMLLTNAVQPN-VAWPQSGRQVAIVPSWSQQT O_latipes_ENSORLP00000020125 -FQ-------GSGLQASPSKHTSYSVRMENAVPIV------------------------------------------------------------------------------------- M_domestica_ENSMODP00000029014 -FQ--------TGLQAP-TKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQ-----------------------------------------------QAWPGGTQQILLPSTWQQLP M_domestica_ENSMODP00000017168 -FQGLSYSFLDTGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQGLCLGYIKGFLHPHC-RDFAKTFFYSFKIKCPQKEIRSIGQNLEVS-QAWPSGTQQILLPPAWQQLT T_rubripes_ENSTRUP00000020840 -FQ---------GLQTSPSKHTSYSVRMENAVPIVTQAPGAQPLQIQPGLLTQ-----------------------------------------------QAWPSGTQQILLPPAWQQL- D_rerio_ENSDARP00000062342 -FQ---------GLQASPSKHTGYSVRMENAVPIVTQAPGAQPLQIQPGLLTQ-----------------------------------------------QAWPSGTQQILLPPAWQQL- T_guttata_ENSTGUP00000005223 -IQ---------GIPTSHSKPTSFSLRVDNAVPLVTQAHAIQPLQIRAGILS------------------------------------------------QAWSNQTQQILVP-AWQQVA A_carolinensis_ENSACAP00000016703 -FQ---------GLQTSPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQ-----------------------------------------------QAWPSGAQQILLPPAWQQLT C_familiaris_ENSCAFP00000006000 -FQ--------VGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQHRDTLFMVSYVEPEVWVTITQERAVPFCLLYPKGSYFLIQKTLKTL-QAWPSGTQQILLPPAWQQLT X_tropicalis_ENSXETP00000003569 -FQ-------AAGLQAT-TKHSGFPVRMDNSVPIVPQAPAAQPLQIQSGVLTQ-----------------------------------------------QAWPGGTQQILLPSTWQQLP G_gallus_ENSGALP00000020844 -FQ---------GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQ-----------------------------------------------QAWPSGTQQILLPPAWQQLT T_nigroviridis_ENSTNIP00000022455 -FQ---------GLQASPSKHTSYSVRMENAVPIVTQAPGAQPLQIQPGLLTQ-----------------------------------------------PAWPSGTQQILLPPAWQQL- M_mulatta_ENSMMUP00000003337 -FQ---------GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQ-----------------------------------------------QAWPSGTQQILLPPAWQQLT P_troglodytes_ENSPTRP00000033846 -FQ---------GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQ-----------------------------------------------QAWPSGTQQILLPPAWQQLT H_sapiens_ENSP00000263551 -FQ---------GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQ-----------------------------------------------QAWPSGTQQILLPPAWQQLT R_norvegicus_ENSRNOP00000010384 -FQ---------GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQ-----------------------------------------------QAWPGGAQQILLPPAWQQLT M_musculus_ENSMUSP00000045457 -FQ---------GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQ-----------------------------------------------QAWPGGAQQILLPPAWQQLT T_guttata_ENSTGUP00000011747 -FQ---------GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQ-----------------------------------------------QAWPSGTQQILLPPAWQQLT E_caballus_ENSECAP00000007300 -FQ---------GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQ-----------------------------------------------QAWPSGTQQILLPPAWQQLT P_troglodytes_ENSPTRP00000006052 -IQ---------GIPATHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLS------------------------------------------------QTWSGRTQQMLVP-AWQQVT P_pygmaeus_ENSPPYP00000003875 -IQ---------GIPATHGKPTGYSIRLDNTVPLVTQAPAVQPLQIRPGVLS------------------------------------------------QTWSGRTQQMLVP-AWQQVT G_gallus_ENSGALP00000002998 -FQ--------TGLQAT-TKHSGFPVRMENAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQV-ATITPQYAVPFTLNCAAGRPALVEQTAAVL-QAWPGGTQQILLPSTWQQLP G_gallus_ENSGALP00000019093 -LQ---------GITTNHSKPTSFSLRVDNAVPLVTQAHAIQPLQIRAGILS------------------------------------------------QTWSNHTQQILVP-AWQQVA H_sapiens_ENSP00000304226 -IQ---------GIPATHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLS------------------------------------------------QTWSGRTQQMLVP-AWQQVT M_domestica_ENSMODP00000012226 -IQ---------GIPANPAKAGNYSLRVDNAVPLVSQAPTIQPLQIRPGVLSQ-----------------------------------------------QTWSNRTQQILVP-TWQQVT A_carolinensis_ENSACAP00000002399 -FQ--------TGLQAT-TKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLAQGSCTPLMVATLHPQV-ATITPQYAVPFTLNCAAGRPALVEQTAAVL-QAWPGGTQQILLPSTWQQIP E_caballus_ENSECAP00000013135 -FQ--------TGLQAT-TKHSGFPVRMDNAVPIVPQAPAAQPLQIQPGVLTQGSCTPLMVATLHPQV-ATITPQYAVPFTLSCAAGRPALVEQTAAVL-QAWPGGTQQILLPSTWQQLP C_familiaris_ENSCAFP00000013694 -FQ--------TGLQAT-TKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQV-ATITPQYAVPFTLSCAAGRPALVEQTAAVL-QAWPGGTQQILLPSTWQQLP C_familiaris_ENSCAFP00000010754 -IQ---------GIPATHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLSQ-----------------------------------------------QTWSGRTQQMLVP-AWQQVT E_caballus_ENSECAP00000018143 -IQ---------GIPATHGKPTSYSIRVDNAVPLVTQAPAVQPLQIRAGALS------------------------------------------------QTWSGRAQQMLVP-AWQQVA H_sapiens_ENSP00000358574 -FQ--------TGLQAT-TKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQV-ATITPQYAVPFTLSCAAGRPALVEQTAAVL-QAWPGGTQQILLPSTWQQLP P_troglodytes_ENSPTRP00000001943 -FQ--------TGLQAT-TKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQV-ATITPQYAVPFTLSCAAGRPALVEQTAAVL-QAWPGGTQQILLPSTWQQLP B_taurus_ENSBTAP00000015051 -FQ--------TGLQAT-TKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQV-ATITPQYAVPFTLSCAAGRPALVEQTAAVL-QAWPGGTQQILLPSTWQQLP T_guttata_ENSTGUP00000001607 -FQ--------TGLQAT-TKHSGFPVRMENAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQV-ATITPQYAVPFTLNCAAGRPALVEQTAAVL-QAWPGGTQQILLPSTWQQLP M_musculus_ENSMUSP00000106754 -IQ---------GIPAAHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLSQ-----------------------------------------------QTWSGRTQQMLIP-AWQQVT B_taurus_ENSBTAP00000039475 -IQ---------GIPATHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLSQ-----------------------------------------------QTWSGRTQQMLIP-AWQQVT M_musculus_ENSMUSP00000113998 -FQ--------TGLQAT-TKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQV-ATITPQYAVPFTLSCAAGRPALVEQTAAVL-QAWPGGTQQILLPSAWQQLP A_carolinensis_ENSACAP00000003036 -IQ---------GIPSNHGKPNGYSIRVDNAVPLVTQAPTLQPLQIR-GVLS------------------------------------------------QTWSNRAQQLLLP-TWQQIT R_norvegicus_ENSRNOP00000052927 -FQ--------TGLQAT-TKHSGFPVRMDNAVPLVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQV-ATITPQYAVPFTLSCAAGRPALVEQTAAVL-QAWPGGTQQILLPSAWQQLP O_anatinus_ENSOANP00000023838 -IQ---------GIPANHGKPTSYSVRVDNAVPLVTQAPAIQPLQIRPGVLS------------------------------------------------QTWSNRTQQILIP-AWQQVT T_rubripes_ENSTRUP00000027188 TIQ---------GLQPS-NKSSTFPVRMENSVPIVPQNQSAQSLQIQPNMLTQGSCTPLMVATLHPPS-AGIAPQYSLPLGLGAGVAQPTLLEHTATVL-QAWPTGTQQILIPSSWQQVP R_norvegicus_ENSRNOP00000015775 -IQ---------GIPAAHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLSQ-----------------------------------------------QTWSGRTQQMLIP-AWQQVT D_rerio_ENSDARP00000083736 -IQ---------GLPPNPNKPAGYSVSMESTVPLVTQASAIQPLQIRPGVITQ-----------------------------------------------QGWSNRAQQILVP-TWPQVT G_aculeatus_ENSGACP00000017894 -FQ---------GLQASPSKHTSYSVRMENAVPIVTQAPGAQPLQIQPGLLTQ-----------------------------------------------QAWPSGTQQILLPPAWQQL- T_rubripes_ENSTRUP00000010045 -IQ---------GIPTNPPKPAGYSVRMEASVPLVTQAPPIQPLQIRPGVITQE----------------------------------------------QAWSNRAQQILVP-AWQQVT O_latipes_ENSORLP00000015420 -MQ---------GIRSNLNQPATY------SVPMVTQAPPIQPLSVRPGVMA------------------------------------------------QAWPNRSQQLLVPAAWQQMT T_rubripes_ENSTRUP00000004224 -MQ---------GALATCCSQSNLNQPAGYSVPMVTQAPPMQSLPLRAGVIAQ-----------------------------------------------QAWPSQSQQLLVQAAWQQMT P_pygmaeus_ENSPPYP00000020253 -FQ---------GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQ-----------------------------------------------QAWPSGTQQILLPPAWQQLT G_aculeatus_ENSGACP00000021106 -IQ---------GIPTNTAKPTGYSVRMEGSVPLVTQAPSIQPIQIRPGVIT------------------------------------------------QSWSSRAQQILVP-TWQQVT G_gorilla_ENSGGOP00000003977 -FQ---------GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQ-----------------------------------------------XXXXXXXXXXXXXXXXXXXX G_aculeatus_ENSGACP00000000924 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000494 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004833-PA ------------------------------------------------------------------------------------------------------------------------ 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0072450 ------------PAHSLIVDST----PLFNVEEIYPKH--HL-------NLP--RNDLKKESPAHHIAKGNSYRVPRHEKKEHQQLSPVKKRVKESSPPHQQRYQ--RAAHVSPQYHAHH A_gambiae_AGAP007342-PA G-----------PAHSLIVDSA----PFLKLEGIYPNP--HL-------NIQTSHHEPKKESPVHHLVVRKYSSVSRHDKKENNQLSPVKKRVKENTPPH-QRYN---RSHMCPQYHDNG A_aegypti_AAEL003731-PA G------------PHSLIVDSA----PFLNVEEIYPKP--HL-------NIQTRHPEPKKESPVHHLV------VSRHDKKENNQLSPVKKRVKENTPPHQQRYNSNRNNHMCQQYHDQQ O_latipes_ENSORLP00000020125 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000029014 GVALHNSV----QPTAVIPETM----GSNQQLGDW--R--QV-------TCY-FFYSTLMQ--QPSLLTNHV-TLATAQ--------PLNVGV----------------AHVVRQQQSGS M_domestica_ENSMODP00000017168 GVATHTSV----QHATVIPETM----AGTQQLADW--R--NT-------HTHGSHYNPIMQ--QPALLTGHV-TLPATQ--------PLNVGV----------------AHVMRQQPTST T_rubripes_ENSTRUP00000020840 ---THTSV----QHATVIPDSM----SSTQPLANW--R--NS-------HPHNSHYNPIMQ--QPALLASHV-TLPSNQ--------TLNVGV----------------AHVMRQPSTNN D_rerio_ENSDARP00000062342 ---THTSV----QHATVIPDSM----TSSQPLANW--R--NS-------HPHGSHYNPIMQ--QPALLAGHV-TLPPQQ--------PLNVGV----------------AHVMRQPSNNQ T_guttata_ENSTGUP00000005223 PVAA--------PATSLASDPV----AGPQRLGDW--G--KM-------ITQGTHYSSMIP--QP-LLTHQI-TLSAPQ--------PISVGI----------------AHVVWPQPA-- A_carolinensis_ENSACAP00000016703 GVAAHTSV----QHAAVIPETM----AGTQPLADW--R--NT-------HAHGSHYNPIMQ--QPALLASHV-TLPAAQ--------PLNVGV----------------AHVMRQQPTST C_familiaris_ENSCAFP00000006000 GVATHTSV----QHATVIPETM----AGTQQLADW--R--NT-------HAHGSHYNPIMQ--QPALLTGHV-TLPAAQ--------PLNVGV----------------AHVMRQQPTST X_tropicalis_ENSXETP00000003569 GVALHNSV----QPTAMIPETI----GNNQQLTDW--R--NA-------HSHGNQYSTLMQ--QPSLLANHV-TLAAAQ--------PLNVGV----------------AHVVRQQQNSN G_gallus_ENSGALP00000020844 GVATHTSV----QHATVIPESM----AGTQPLADW--R--NT-------HAHGSHYNPIMQ--QPALLASHV-TLPAAQ--------PVNVGV----------------AHVMRQPPAAA T_nigroviridis_ENSTNIP00000022455 ---THTSV----QHATVIPDAM----SSTQPLANW--R--NS-------HPHNSHYNPIMQ--QPALLASHV-TLPSNQ--------TLNVGV----------------AHVMRQPSTNN M_mulatta_ENSMMUP00000003337 GVATHTSV----QHATVIPETM----AGTQQLADW--R--NT-------HAHGSHYNPIMQ--QPALLTGHV-TLPAAQ--------PLNVGV----------------AHVMRQQPTST P_troglodytes_ENSPTRP00000033846 GVATHTSV----QHATVIPETM----AGTQQLADW--R--NT-------HAHGSHYNPIMQ--QPALLTGHV-TLPAAQ--------PLNVGV----------------AHVMRQQPTST H_sapiens_ENSP00000263551 GVATHTSV----QHATVIPETM----AGTQQLADW--R--NT-------HAHGSHYNPIMQ--QPALLTGHV-TLPAAQ--------PLNVGV----------------AHVMRQQPTST R_norvegicus_ENSRNOP00000010384 GVATHTSV----QHAAVIPETM----AGTQQLADW--R--NT-------HAHGSHYNPIMQ--QPALLTGHV-TLPAAQ--------PLNVGV----------------AHVMRQQPTST M_musculus_ENSMUSP00000045457 GVATHTSV----QHAAVIPETM----AGTQQLADW--R--NT-------HAHGSHYNPIMQ--QPALLTGHV-TLPAAQ--------PLNVGV----------------AHVMRQQPTST T_guttata_ENSTGUP00000011747 GVATHTSV----QHATVIPESM----AGTQPLADW--R--NT-------HAHGSHYNPIMQ--QPTLLASHV-ALPAAQ--------PVNVGV----------------AHVMRQPPAAA E_caballus_ENSECAP00000007300 GVATHTSV----QHATVIPETM----AGTQQLADW--R--NT-------HAHGSHYNPIMQ--QPALLTGHV-TLPAAQ--------PLNVGV----------------AHVMRQQPTST P_troglodytes_ENSPTRP00000006052 PLAP--------ATTTLTSESV----AGSHRLGDW--G--KM-------ISCSNHYNSVMP--QP-LLTNQI-TLSAPQ--------PVSVGI----------------AHVVWPQPA-- P_pygmaeus_ENSPPYP00000003875 PLAP--------ATTTLTSESV----AGSHRLGDW--G--KM-------ISCSNHYNSVMP--QP-LLTNQI-TLSAPQ--------PVSVGI----------------AHVVWPQPA-- G_gallus_ENSGALP00000002998 GVALHNSV----QPAAVIPETI----GSSQQLADWSPR--NA-------HSHGNQYSTLMQ--QPSLLTNHV-TLATAQ--------PLNVGV----------------AHVVRQQQSSN G_gallus_ENSGALP00000019093 PVAA--------PATSLASDPV----AGPQRLGDW--G--KM-------ITQGTHYNSVMP--QP-LLTHQI-TFSAPQ--------PISVGI----------------AHVVWPQPA-- H_sapiens_ENSP00000304226 PLAP--------ATTTLTSESV----AGSHRLGDW--G--KM-------ISCSNHYNSVMP--QP-LLTNQI-TLSAPQ--------PVSVGI----------------AHVVWPQPA-- M_domestica_ENSMODP00000012226 PVGP--------STVALTSETV----AGPQRLGDW--G--KM-------ISHSNHYNSVIP--PP-LLANQL-TLSAPQ--------PISVGI----------------AHVVWPQPA-- A_carolinensis_ENSACAP00000002399 GVALHNSV----QPTAVIPETI----GSNQQLTDW--R--NA-------HSHGNQYSTIMQ--QPSLLTNHV-TLATTQ--------PLNVGV----------------AHVVRQQQNNA E_caballus_ENSECAP00000013135 GVALHNSV----QPTAVIPEAM----GSGQQLADW--RQEHA-------HSHGNQYSTIMQ--QPSLLTNHV-TLATAQ--------PLNVGV----------------AHVVRQQQSSS C_familiaris_ENSCAFP00000013694 GVALHNSV----QPTAVIPEAM----GSGQQLTDW--R--NA-------HSHGSQYSTIMQ--QPSLLTNHV-TLATAQ--------PLNVGV----------------AHVVRQQQSSS C_familiaris_ENSCAFP00000010754 PMAP--------ATTALTSEGV----AGSQRLGDW--G--KM-------ISHSNHYSSVMP--QP-LLTNQI-TLSAPQ--------PISVGI----------------AHVVWPQPA-- E_caballus_ENSECAP00000018143 PLAP--------AATTLTSEGV----AGSQRLGDW--G--KM-------ISHSNPYSSVMP--QP-LLTNQI-TLSAPQ--------PISVGI----------------AHVVWPQPA-- H_sapiens_ENSP00000358574 GVALHNSV----QPTAMIPEAM----GSGQQLADW--R--NA-------HSHGNQYSTIMQ--QPSLLTNHV-TLATAQ--------PLNVGV----------------AHVVRQQQSSS P_troglodytes_ENSPTRP00000001943 GVALHNSV----QPTAMIPEAM----GSGQQLADW--R--NA-------HSHGNQYSTIMQ--QPSLLTNHV-TLATAQ--------PLNVGV----------------AHVVRQQQSSS B_taurus_ENSBTAP00000015051 GVALHNSV----QPTAVIPEAM----GSGQQLTDW--R--NA-------HSHGNQYSTIMQ--QPSLLTNHV-TLATAQ--------PLNVGV----------------AHVVRQQQSSS T_guttata_ENSTGUP00000001607 GVALHNSV----QPAAVIPETI----GSSQQLADW--R--NA-------HSHGNQYSTLMQ--QPSLLTNHV-TLATAQ--------PLNVGV----------------AHVVRQQQSSN M_musculus_ENSMUSP00000106754 PMAP--------AAATLTSEGM----AGSQRLGDW--G--KM-------IPHSNHYNSVMP--PP-LLTNQI-TLSAPQ--------PISVGI----------------AHVVWPQPA-- B_taurus_ENSBTAP00000039475 PLAP--------ATTALASEGV----AGSQRLGDW--G--KM-------ISHSNHYSSMMP--QP-LLTNQI-TLSAPQ--------PISVGI----------------AHVVWPQPA-- M_musculus_ENSMUSP00000113998 GVALHNSV----QPAAVIPEAM----GSSQQLADW--R--NA-------HSHGNQYSTIMQ--QPSLLTNHV-TLATAQ--------PLNVGV----------------AHVVRQQQSSS A_carolinensis_ENSACAP00000003036 PVAP---------ATTLASDSV----AGPQGLGDW--G--KM-------LPRCNHYNSVMT--QS-LLTNQI-TLSAPQ--------PISVGI----------------AHVVWPQPT-- R_norvegicus_ENSRNOP00000052927 GVALHNSV----QPTAVIPEAM----GSSQQLADW--R--QAQAAPTSQHPLWECYSTIMQ--QPSLLTNHV-TLATAQ--------PLNVGV----------------AHVVRQQQSSS O_anatinus_ENSOANP00000023838 ALAP--------STTTLTSETV----AGPQRLGDW--G--KV-------ISHSNHYNSVLP--QP-LLTNQI-TLSAPQ--------PISVGI----------------AHVVWPQPA-- T_rubripes_ENSTRUP00000027188 GVAIHSSA----HQSNVAESPLGPVDGATQQQHNW--R--NS--------------TTVVK--QC-LMGFFL------N--------SVNRGT----------------AQARAQQEKKK R_norvegicus_ENSRNOP00000015775 PMAP--------AAATLTSEGM----AGSQRLGDW--G--KM-------IPHSNHYNSVMP--PP-LLTNQI-TLSAPQ--------PISVGI----------------AHVVWPQPA-- D_rerio_ENSDARP00000083736 PVAP-----VAPSATTLASEPV----AGPQRLADW--G--KV-------HSHGNHYSSMMPHHQP-LLTNPM-AMSAHQ--------PISIGI----------------AHVVWPQPA-- G_aculeatus_ENSGACP00000017894 ---THTSV----QHATVIPDSM----SSAQPLANW--R--NS-------HPHGTHYNPIMQ--QPALLAGHV-TLPSNQ--------TLSVGV----------------AHVMRQASTNN T_rubripes_ENSTRUP00000010045 SVPP--------PPAT--SDTV----VGSQRLVDW--G--KV-------HPHGNHYSSMIAHPQP-FLTNQM-TMPTHQ--------PVNIGI----------------AHVVWPQPA-- O_latipes_ENSORLP00000015420 PMGPPPSHPPPPPPTSLTNDNT----AGPQMIGDW--G--KV-------RPPSSHYNTLMQ--QP-LLTNQMPALSAHQ--------PINIGI----------------AHVVWPQTT-- T_rubripes_ENSTRUP00000004224 SMAPPPSHP---PPPPLANDTP----NGQQRLGDW--G--KV-------HSHGGRYNSLMQ--QP-VLTNRMAALSTHQ--------PVNVGV----------------AHVVWPQPA-- P_pygmaeus_ENSPPYP00000020253 GVATHTSV----QHATVIPETM----AGTQQLADW--R--NT-------HAHGSHYNPIMQ--QPALLTGHV-TLPAAQ--------PLNVGV----------------AHVMRQQPTST G_aculeatus_ENSGACP00000021106 SVPP--------PPTTLAADSV----AGSQRLGDW--G--KV-------RPHGNHYSSMIAHSQP-FLTNQM-AMSTHQ--------PINIGI----------------AHVVWPQPA-- G_gorilla_ENSGGOP00000003977 XXXXXXXX----XXXXXXXXXX----XXXXXXXXX--X--XX-------XXXXXXXXXXXX--XXXXXXXXX-XXXXXX--------XXXXXX----------------XXXXXXXXXXX G_aculeatus_ENSGACP00000000924 ---------------AAITDAN---------------G--NI---------------------QP------------------------------------------------------- G_aculeatus_ENSGACP00000000494 -----------------LGDSG---------------D--GI---------------------------------------------PL------------------------------- A_gambiae_AGAP004833-PA ------------------------------------------------------------------------------------------------------------------------ 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0072450 NCNYGNGSGYSASAG---------------------------------------------SVVASSAASSSN--IVNGSSSSSHHHHVPVAHAQPYSSSSGHHIVSNCNANGGAGGAVVY A_gambiae_AGAP007342-PA TGSGATAGSSSAVAS---------------------------------------------SSGGAGGSSVVMGGSGNIHHSGSGHHHHG------------------------SSGHIHH A_aegypti_AAEL003731-PA IPPQPHHHHSSSSSS---------------------------------------------SSQQPPAQSQLQ--QANSSSSGNHHHHHHYQQIDSGSMGGGSGSNGSSSSMMMNSGSIHH O_latipes_ENSORLP00000020125 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000029014 L-PSKKNKQPAQASANSYMVKWNFGCCSHPCSLGWSQLFLMCEGIFISIHLTGKSPKKTITVSTLDVLPTQV--Y-----------------SLI--------GSSP---LR-TNSSYN- M_domestica_ENSMODP00000017168 T-SSRKNKQHQATAR---------------------------------------------CVQT---------------------ENTPPRCAMV--------HNSP---ACSTSVTCG- T_rubripes_ENSTRUP00000020840 NHSSKKNKQHQMSAR---------------------------------------------NASAYEVSSSQV--VLSPQRSKRVKENTPPRCAVL--------QNGSVS-NCQAPQSCGG D_rerio_ENSDARP00000062342 S-NSKKNKQHQMNNR---------------------------------------------NVSGYDVSSTQP--VTSPQRSKRVKENTPPRCAVV--------QNGPPS-TCVPSQTCTG T_guttata_ENSTGUP00000005223 --ATKRNKLCQNRWLLLLFFFWK-N----------LSFLFKFSM---------SNMLQNTNIQNSAFISPKI--LNL-KAV----KRIS-----CI-------EAQDNLNSEGREGGCC- A_carolinensis_ENSACAP00000016703 T-SSRKSKQHQSSAR---------------------------------------------NVSNFEVSSSQT--ISSPQRSKRVKENTPPRCAMV--------HNSP---ACSTSVTCG- C_familiaris_ENSCAFP00000006000 T-SSRKSKQHQSSA------------------------------------------------------SKTK--LDYYKKQVYVLLGS---------------HGTD---TTKVSKSC-- X_tropicalis_ENSXETP00000003569 T-STKKNKQQASQSSSK-------------------------------------------ALSSLDVIPSQV--Y-----------------SLV--------GSSP---LQ-ASSSYN- G_gallus_ENSGALP00000020844 T-STRKSKQHQSAPR---------------------------------------------NASTYEVSSSQS--ISSPQRSKRVKENTPPRCAMV--------HNSP---ACSTAVTCG- T_nigroviridis_ENSTNIP00000022455 NHSSKKNKQHQMSAR---------------------------------------------NASAYEVSSSQV--VLSPQRSKRVKENTPPRCAVL--------QNGSAT-SCQAPQSCGG M_mulatta_ENSMMUP00000003337 T-SSRKSKQHQ-SVR---------------------------------------------NVSTCEVSSSQA--ISSPQRSKRVKENTPPRCAMV--------HSSP---ACSTSVTCG- P_troglodytes_ENSPTRP00000033846 T-SSRKSKQHQSSVR---------------------------------------------NVSTCEVSSSQA--ISSPQRSKRVKENTPPRCAMV--------HSSP---ACSTSVTCG- H_sapiens_ENSP00000263551 T-SSRKSKQHQSSVR---------------------------------------------NVSTCEVSSSQA--ISSPQRSKRVKENTPPRCAMV--------HSSP---ACSTSVTCG- R_norvegicus_ENSRNOP00000010384 T-SSRKSKQHQSSAR---------------------------------------------NVSTCEVTSSQA--ISSPQRSKRVKENTPPRCAMV--------HSSP---ACSTSLTCG- M_musculus_ENSMUSP00000045457 T-SSRKSKQHQSSVR---------------------------------------------NVSTCEVTSSQA--ISSPQRSKRVKENTPPRCAMV--------HSSP---ACSTSVTCG- T_guttata_ENSTGUP00000011747 --SARKSKQHQSAPR---------------------------------------------NASTYEVSSSQS--ISSPQRSKRVKENTPPRCAMV--------HNSP---ACSTSVTCG- E_caballus_ENSECAP00000007300 T-SSRKSKQHQSSAR---------------------------------------------NVSTCEVSSSQA--ISSPQRSKRVKENTPPRCALV--------HSSP---ACSSSVTCG- P_troglodytes_ENSPTRP00000006052 --TTKKNKQCQNRGILVKLMEWEPG----------REEINAFSW---------SNSLQNTNIPHSAFISPKI--ING-KDV----EEVS-----CI-------ETQDNQNSEGEARNCC- P_pygmaeus_ENSPPYP00000003875 --TTKKNKQCQNRGILVKLMGWEPG----------REEINAFSW---------SNSLQNTNIPHSAFISSKI--ING-KDV----EEVS-----CI-------ETQDNQNSEGEARNCC- G_gallus_ENSGALP00000002998 V-PAKKNKQPAPSTAK--------------------------------------------SSSTLETVPTQV--Y-----------------SLI--------GSSP---LRSTSSSSN- G_gallus_ENSGALP00000019093 --ATKRNKLCQNR----------------------------------------SNALQNTNIQNSALISPKI--INL-KAV----KRIS-----CI-------EAQDNHNSDGQESNCC- H_sapiens_ENSP00000304226 --TTKKNKQCQNRGILVKLMEWEPG----------REEINAFSW---------SNSLQNTNIPHSAFISPKI--ING-KDV----EEVS-----CI-------ETQDNQNSEGEARNCC- M_domestica_ENSMODP00000012226 --STKKNKLCQNRGILVKLMEWEPG----------REEINTFTW---------SNSLQNTNIPNSAFISPKI--INM-KAV----EQVS-----CT-------ETQDNHNLE-EERNYC- A_carolinensis_ENSACAP00000002399 V-PAKKNKPPSHSATK--------------------------------------------PTSTLEAIPSQV--Y-----------------SLI--------GSSP---LRATSSSSN- E_caballus_ENSECAP00000013135 L-PSKKNKQAAPVSSK----------------------------------------------SSLDVLPSQV--Y-----------------SLV--------GSSP---LR-TTSSYN- C_familiaris_ENSCAFP00000013694 L-PSKKNKQSAPVSSK----------------------------------------------SSLDVLPSQV--Y-----------------SLV--------GSSP---LR-TT-SYN- C_familiaris_ENSCAFP00000010754 --TAKKNKLCQNRGILVKLMEWEPG----------REEINAFSW---------SNSLQNTNVPHSTFISPKI--VNG-KDV----EEVR-----CV-------ETQDNHNSEGGARDCC- E_caballus_ENSECAP00000018143 --ATKKNKLCQNRGILVKLMEWEPG----------RQEINAFSW---------SNSLQNTNAPHSAFISPKI--VNG-KDV----EEVS-----CV-------ETQDNHSSEGEARRCC- H_sapiens_ENSP00000358574 L-PSKKNKQSAPVSSK----------------------------------------------SSLDVLPSQV--Y-----------------SLV--------GSSP---LR-TTSSYN- P_troglodytes_ENSPTRP00000001943 L-PSKKNKQSAPVSSK----------------------------------------------SSLDVLPSQV--Y-----------------SLV--------GSSP---LR-TTSSYN- B_taurus_ENSBTAP00000015051 L-PSKKNKQSAPVSSK----------------------------------------------SSLDVLPSQV--Y-----------------SLV--------GSSP---LR-TTSSYN- T_guttata_ENSTGUP00000001607 V-PAKKNKQPAPSTAN----------------------------------------------SSLEPVPTQV--Y-----------------SLI--------GSSP---LRSTSSSSN- M_musculus_ENSMUSP00000106754 --TTKKNKLCQNRGILVRLMEWEPG----------REEINAFRW---------SNSLQNTNIPHSAFISPKI--ISG-KEV----EEVS-----CV-------DTQDNHTSEGEAGTCR- B_taurus_ENSBTAP00000039475 --TTKKNKLCQNR----------------------------------------SNSLQNTNIPQSAFISPKT--VTG-KDV----QEVS-----CI-------ETQDNRNSEGEAGNCC- M_musculus_ENSMUSP00000113998 L-PSKKNKQSAPVSSK----------------------------------------------SSLEVLPSQV--Y-----------------SLV--------GSSP---LR-TTSSYN- A_carolinensis_ENSACAP00000003036 --PTKRNKVCQNR----------------------------------------SNVLQNTNIQNSAFISPKI--FNV-KTG----EKVS-----CV-------ETQDNHNLEGQESNCC- R_norvegicus_ENSRNOP00000052927 L-PSRKNKQSAPVSST----------------------------------------------SSLEVLPSQV--Y-----------------SLV--------GSSP---LR-TTSSYN- O_anatinus_ENSOANP00000023838 --AAKKHKMCQNRGILVKLMEWEPG----------REEINAFTW---------SNSLQNTNIPNSAFISPKI--INM-KAV----ERIS-----CL-------ETQDNHNSEGGERSCC- T_rubripes_ENSTRUP00000027188 V-KARRGE----------------------------------------------NTFPLCSSMLHPITSPLF--PNLCRGV--------------------------STASFLSSSNIT- R_norvegicus_ENSRNOP00000015775 --TTKKNKLCQNR----------------------------------------SNSLQNTNVPHSAFISPKI--ISG-KEV----EEVS-----CV-------ETQDNHTSEGEARTCH- D_rerio_ENSDARP00000083736 --ANKRNKPSS------------------------------NRC---------NNFMHSTNSQNVSCQSPKM--VNSAKNT----EE---EAADCV-------VEAESEAVQEEESVCC- G_aculeatus_ENSGACP00000017894 NSTSKKNKQHQMSAR---------------------------------------------NMSAYEVSSSQT--VLSPQRSKRVKENTPPRCAVL--------QSGSSSFNCAPLQGYGG T_rubripes_ENSTRUP00000010045 --ANKRSKPCVNRG---------------------------------------NNFSQTTNIQNLTCQSPKM--ADIAKNV----QEVEEEAARCPETGRANGAKQATEQADENEESCC- O_latipes_ENSORLP00000015420 ---AKRNRHGHNRLNFFLVSKWLKG----------PLDFFQTCWGSPIQPFSQRNLSHYGN---GSCRTPKM--ADVVGQAAAGRQQRQGAAS-----QGESRQPDTQNKNEKRQ----- T_rubripes_ENSTRUP00000004224 ---NKRNRHSQNR-----------------------------------------NLSSQSNVQ--PCRTLKA--ASMLARARVQREEPHREAALLEPGGSEALSVDEEDDNGEEELTCF- P_pygmaeus_ENSPPYP00000020253 T-SSRKSKQHQSSVR---------------------------------------------NVSTCEVSSSQA--ISSPQRSKRVKENTPPRCAMV--------HSSP---ACSTSVTCG- G_aculeatus_ENSGACP00000021106 --ANKRAKPCVNRYNEQAYTKMG------------SSILTLNRG---------SNFSQNTNVQNIACQSPKM--ADTAKNV----QQVE---ARFPEEGHAAGEGAGTPQVE-EDENCC- G_gorilla_ENSGGOP00000003977 X-XXXXXXXXXXXXX---------------------------------------------XXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXX--------XXXX---XXXXXXXXX- G_aculeatus_ENSGACP00000000924 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000494 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004833-PA ------------------------------------------------------------------------------------------------------------------------ 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0072450 QQPPAHAHQQHGQQPHPQSSQHPQ----------H----VK------QP-TITIHDTPSPT-AVITISDSEDEGGE-----AGGAQVPVLKQRAHAQSQTSGS--LLQHAPSSSCSRSSA A_gambiae_AGAP007342-PA GHGHAH-HGGGGGGGAGHHGSSHHGHGGSGSYGGS----SK------QQ-TITIHDTPSPT-AVITISDSEDESPE-----VKHSTSSS--------------------------SKGSS A_aegypti_AAEL003731-PA GSSSGH-HHGSGSGSHIHHSHSSH----------N----SK------QQ-TITIHDTPSPT-AVITISDSEDETAD-----VKQSTSSS----------------KSQHQSTSMCGPSSS O_latipes_ENSORLP00000020125 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000029014 -------------------PLVPS----------Q----DQ------HQ-PIIIPDTPSPPVSVITIRSDTDEEED-----SKRKSFGECGHSAPKILCLSTGNRLGCEVLVFHCTSQST M_domestica_ENSMODP00000017168 -----W---------GDVASSTAK----------E----RQ------RQ-TIVIPDTPSPTVSVITISSDTDEEEE-----QKHAP---------------------------------- T_rubripes_ENSTRUP00000020840 SG---W-----GASDAEQTCSTTR----------D----QQHQHHVPRQ-TIVIPDTPSPAVSIITISSDTDEEED-----HKHNN---------------------------------- D_rerio_ENSDARP00000062342 GG---W--------GGEQACSTTR----------D----HHGQHNPPRQ-TIIIPDTPSPAVSIITISSDTDEEDD-----LKQPTN--------------------------------- T_guttata_ENSTGUP00000005223 -----E-----ASVR-LAPGPPGP----------G----SP------RR-ALLLAGSPSPAVSVITISSDTDEDDV-----ARTHSLRECKGSLECEACQNT---LNIDRVCSLSSPDST A_carolinensis_ENSACAP00000016703 -----W---------GDGASSTTR----------E----RQ------RQ-TIVIPDTPSPAVSVITISSDTDEEEE-----QKHAP---------------------------------- C_familiaris_ENSCAFP00000006000 ---------------------TTR----------E----RQ------RQ-TIVIPDTPSPTVSVITISSDTDEEEE-----QKHAP---------------------------------- X_tropicalis_ENSXETP00000003569 -------------------PLLPL----------Q----EQ------RQ-PIVIPDTPSPPVSVITIRSDTDEEED-----SKYKP---------------------------------- G_gallus_ENSGALP00000020844 -----W---------GDMATSTTR----------E----RQ------RQ-PIIIPDTPSPAVSVITISSDTDEEEE-----QKHAP---------------------------------- T_nigroviridis_ENSTNIP00000022455 GGGGSW-----GPGETEQACSTTR----------DPQHQHQHQHHVPRQ-TIIIPDTPSPAVSIITISSDTDEEED-----HKRNN---------------------------------- M_mulatta_ENSMMUP00000003337 -----W---------GDVASSTTR----------E----RQ------RQ-TIVIPDTPSPTVSVITISSDTDEEEE-----QKHAP---------------------------------- P_troglodytes_ENSPTRP00000033846 -----W---------GDVASSTTR----------E----RQ------RQ-TIVIPDTPSPTVSVITISSDTDEEEE-----QKHAP---------------------------------- H_sapiens_ENSP00000263551 -----W---------GDVASSTTR----------E----RQ------RQ-TIVIPDTPSPTVSVITISSDTDEEEE-----QKHAP---------------------------------- R_norvegicus_ENSRNOP00000010384 -----W---------GDGASSTTR----------D----RQ------RQ-TIVIPDTPSPTVSVITISSDTDEEEE-----QKHAP---------------------------------- M_musculus_ENSMUSP00000045457 -----W---------GDVASSTTR----------E----RQ------RQ-TIVIPDTPSPTVSVITISSDTDEEEE-----QKHAP---------------------------------- T_guttata_ENSTGUP00000011747 -----W---------GDVASSSTR----------E----RQ------RQ-TIVIPDTPSPAVSVITISSDTDEEEE-----QKHAP---------------------------------- E_caballus_ENSECAP00000007300 -----W---------GDGASSTAR----------E----RQ------RQ-TIVIPDTPSPTVSVITISSDTDEEEE-----QKHAP---------------------------------- P_troglodytes_ENSPTRP00000006052 -----E-----TSIR-QDSDSSVS----------D----KQ------RQ-TIIIADSPSPAVSVITISSDTDEEET-----SQRHSLRECKGSLDCEACQST---LNIDRMCSLSSPDST P_pygmaeus_ENSPPYP00000003875 -----E-----TSIR-QDSDSSVS----------D----KQ------RQ-TIIIADSPSPAVSVITISSDTDEEET-----S-KHSLRECKGSLDCEACQST---LNIDRMCSLSSPDST G_gallus_ENSGALP00000002998 -------------------VLVPV----------Q----EQ------HQ-PIVIPDTPSPPVSVITIRSDTDEEED-----SKYKP---------------------------------- G_gallus_ENSGALP00000019093 -----E-----ASVR-LEPDSSLS----------N----KQ------RQ-AIFIAGSPSPAVSVITISSDTDEDDL-----GQTRSLRECKGSLDCEACQNT---LNIDRVCSLSSQDST H_sapiens_ENSP00000304226 -----E-----TSIR-QDSDSSVS----------D----KQ------RQ-TIIIADSPSPAVSVITISSDTDEEET-----SQRHSLRECKGSLDCEACQST---LNIDRMCSLSSPDST M_domestica_ENSMODP00000012226 -----K-----TSVR-EEPDSSVS----------D----KQ------RE-AILIADSPSPAVSVITISSDTDEEDA-----APSHSVRNCKGSLDCEACQST---LNIDRMCSLSSPDST A_carolinensis_ENSACAP00000002399 -------------------AVLPG----------Q----EQ------HQ-PIVIPDTPSPPVSVITIRSDTDEEED-----NKYKP---------------------------------- E_caballus_ENSECAP00000013135 -------------------SLVPV----------Q----DQ------HQ-PIIIPDTPSPPVSVITIRSDTDEEED-----NKYKP---------------------------------- C_familiaris_ENSCAFP00000013694 -------------------SLVPV----------P----DQ------HQ-PIIIPDTPSPPVSVITIRSDTDEEED-----NKYKP---------------------------------- C_familiaris_ENSCAFP00000010754 -----E-----TSVQ-QDSDSSVS----------D----KQ------RQ-TIIIADSPSPAVSVITISSDTDEEET-----SQRHSLRECKDSLDCEACQST---LNIDRMCSLSSPDST E_caballus_ENSECAP00000018143 -----E-----THVR-QDSDSSVP----------D----RQ------RQ-TIVIADSPSPAVSVITISSDTDEEEP-----AQRHALRDCKGSVDCEACQST---LNVGRMCSLSSPDST H_sapiens_ENSP00000358574 -------------------SLVPV----------Q----DQ------HQ-PIIIPDTPSPPVSVITIRSDTDEEED-----NKYKP---------------------------------- P_troglodytes_ENSPTRP00000001943 -------------------SLVPV----------Q----DQ------HQ-PIIIPDTPSPPVSVITIRSDTDEEED-----NKYKP---------------------------------- B_taurus_ENSBTAP00000015051 -------------------SLVPV----------Q----DQ------HQ-PIIIPDTPSPAVSVITIRSDTDEEED-----NKYKP---------------------------------- T_guttata_ENSTGUP00000001607 -------------------VLVPV----------Q----EQ------HQ-PIVIPDTPSPPVSVITIRSDTDEEED-----SKYKP---------------------------------- M_musculus_ENSMUSP00000106754 -----E-----ASVR-Q--DSSVS----------D----KQ------RQ-TIIIADSPSPAVSVITISSDSDDEET-----SPRPSLRECKGSLDCEACQST---LNIDRMCSLSSPDST B_taurus_ENSBTAP00000039475 -----D-----TSIR-QDSDSSVS----------D----KQ------RQ-TIIIADSPSPAVSVITISSDTDEEET----SSQRHSLRECKGNLDCEACQST---LNIDRMCSLSSPDST M_musculus_ENSMUSP00000113998 -------------------SLVPV----------Q----DQ------HQ-PIIIPDTPSPPVSVITIRSDTDEEED-----NKYKP---------------------------------- A_carolinensis_ENSACAP00000003036 -----K-----PSIR-KNPDSSVS----------N----KQ------RQ-AIIIADSPSSAVSVITISSDTDEEDV-----AQKHSVAECEGNLDCEACQST---LNIDRVCSLSSPDST R_norvegicus_ENSRNOP00000052927 -------------------SLVPV----------Q----DQ------HQ-PIIIPDTPSPPVSVITIRSDTDEEED-----NKFKP---------------------------------- O_anatinus_ENSOANP00000023838 -----K-----TPVR-QNPDSSVS----------N----KQ------RQ-TILIADSPSPAVSVITISSDTDEEDT-----AQRHSLRECKGSLDCEACQST---LNINRACSLSSPDST T_rubripes_ENSTRUP00000027188 -------------------PPTSS----------V----VM------SQ-PIIISDTPSPAVSIITIHSDTDTEDE-----RKFHP---------------------------------- R_norvegicus_ENSRNOP00000015775 -----E-----ASVR-Q--DSSVS----------D----KQ------RQ-TIIIADSPSPAVSVITISSDTDDEET-----SPRPSLRECKGSLDCEACQST---LNIDRMCSLSSPDST D_rerio_ENSDARP00000083736 -----K-----AE-P-EYEDPTVS----------Q----KQ------RQ-TIVITDSPSPAGSIISISSGTDEDGP----DTQKHAL-ECKGSPDCEACQST---LNMERVCSLSSPDST G_aculeatus_ENSGACP00000017894 GG---W-----GPGESEQASSTTR----------N----HQHQHHLPRQ-TIVIPDTPSPAVSIITISSDTDDEDD-----HKQNK---------------------------------- T_rubripes_ENSTRUP00000010045 -----K-----VE-P-ECEELSVS----------Q----EQ------RQ-AMVISDLVSPTVSVISISSDEVE-------SAQRHSMGECKGSADCEACQST---VSMERVCSLSSPEST O_latipes_ENSORLP00000015420 ---------------------------------------PL------RDVAVLMADTPSPAPSVISIRSDLSDAEEVDGGDPERCRLNECKEECVCEACRNTS--VSMERVCSLSSPDSS T_rubripes_ENSTRUP00000004224 ----------KELVAVGKGRMDVS----------G----QQ------RDVSVLMADTPSPAPSVISIHSELTDGED-----DEEPHHHACKKECACEACRSTA--VSMVRVCSLSSPESS P_pygmaeus_ENSPPYP00000020253 -----W---------GDVASSTTR----------E----RQ------RQ-TIVIPDTPSPTVSVITISSDTDEEEE-----QKHAP---------------------------------- G_aculeatus_ENSGACP00000021106 -----K-----VE-P-DCEELSVS----------Q----EQ------RQ-AMVISDLASPTVSVISISSDEEE-------SAQRHSMGECKGSAACEACQST---VSMERVCSLSSPDST G_gorilla_ENSGGOP00000003977 -----X---------GAVASSTTR----------E----RQ------RQ-TIVIPDTPSPTVSVITISSDTDEEEE-----QKHAP---------------------------------- G_aculeatus_ENSGACP00000000924 -----------------------------------------------RT----------------------------------------------------------------------- G_aculeatus_ENSGACP00000000494 -----------------------------------------------RT----------------------------------------------------------------------- A_gambiae_AGAP004833-PA ------------------------------------------------------------------------------------------------------------------------ 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 1800 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0072450 HQQPHPHPQQQQQQQ--------------------INYGDHDPEDARRRHHAAAAAAVGSPKHHHHQQQQQPA-PPPQQQQQQYQPQPPPQQVLPQPQP--------------------- A_gambiae_AGAP007342-PA HNAASGQACTRGTHQSSSSCRGGGG----GSGGNGCSGGIKTSSSSSNVAHNSSASNQLSGGSGSHQQQPQPQPSSYQQYGQPQ--QQHMSVISSGSSGGNGASCSGGSSSGRQRKSTAV A_aegypti_AAEL003731-PA QQHIRGHPSTNSSSSSSNQCRANMGMS--GVGGSSSSCGIKPSSSSSNIHHSSSSSGSSSHHHSHYHLQQVPQ-SHMQQQQQPQQSQHHPSVISSGSQA--------------------- O_latipes_ENSORLP00000020125 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000029014 KSVGRDDPNACDENS--SLKPRSNVIS--------YVTVNDSPDSDSSL--SSPYSTDTLAAIRGNTGPLLEG-PG-------RVV-TDGPGARTIIVP--------------------- M_domestica_ENSMODP00000017168 ------------T----------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000020840 ------------SS---STKQRKNVIS--------CVTVHDSPDSDCSSH-NSPYTVESRPP--NNNSYDTKM-TI-------LDN-CNNGNPRTIIIP--------------------- D_rerio_ENSDARP00000062342 ------------TST--SSKQRKNVIS--------CVTVHDSPDSDSSN--TSPYAVDSRTNGPNANGYDSKG-AV-------LDN-YSNGNPRTIIIP--------------------- T_guttata_ENSTGUP00000005223 LSTSS----SEQSSP--SPCKRSSSKK-QD------ISIQQAPLILKNAQ-VLLRCQLVRVNDLTDCSE---A-RAS------VNPE-TKSTVCTVVVP--------------------- A_carolinensis_ENSACAP00000016703 ------------TSP--VSKQRKNVIS--------CVTVHDSPYSDSSGN-NSPYAAQRRGGNNNGNTYDAKG-V--------PET-HCNGNPRTIIVP--------------------- C_familiaris_ENSCAFP00000006000 ------------TST--VSKQRKNVIS--------CVTVHDSPYSDSSSN-TSPYSVQHRAGH-HGNACDAKG-S--------LEN-HCTGNPRTIIVP--------------------- X_tropicalis_ENSXETP00000003569 ------------TNS--GMKLRSNVIS--------YVTVNDSPDSDSSV--SSPYLADRHTSVNGVTGVFDMS-NS-------RTAHSQSLNSRTIIVP--------------------- G_gallus_ENSGALP00000020844 ------------TST--LSKQRKNVIS--------CVTVHDSPYSDSSSN-NSPYAVQHRAGQNNGNTYDTKG-V--------PET-HCSGNPRTIIVP--------------------- T_nigroviridis_ENSTNIP00000022455 -------------S---STKQRKNVIS--------CVTVHDSPDSDCSSH-NSPYTVESRPP--NNNGYDTKM-TL-------LDN-CNNGNPRTIIIP--------------------- M_mulatta_ENSMMUP00000003337 ------------TST--VSKQRKNVIS--------CVTVHDSPYSDSSSN-TSPYSVQQRTGHNNANAFDTKG-S--------LEN-HCTGNPRTIIVP--------------------- P_troglodytes_ENSPTRP00000033846 ------------TST--VSKQRKNVIS--------CVTVHDSPYSDSSSN-TSPYSVQQRAGHNNANAFDTKG-S--------LEN-HCTGNPRTIIVP--------------------- H_sapiens_ENSP00000263551 ------------TST--VSKQRKNVIS--------CVTVHDSPYSDSSSN-TSPYSVQQRAGHNNANAFDTKG-S--------LEN-HCTGNPRTIIVP--------------------- R_norvegicus_ENSRNOP00000010384 ------------TST--VSKQRKNVIS--------CVTVHDSPYSDSSSN-TSPYSVQQRTGHNGTNTLDTKG-G--------LEN-HCTGNPRTIIVP--------------------- M_musculus_ENSMUSP00000045457 ------------TST--VSKQRKNVIS--------CVTVHDSPYSDSSSN-TSPYSVQQRTGHNGTNTLDTKG-G--------LEN-HCTGNPRTIIVP--------------------- T_guttata_ENSTGUP00000011747 ------------TST--LSKQRKNVIS--------CVTVHDSPYSDSSSN-NSPYTVQHRTGQNNGNSYDTKG-V--------PET-HCSGNPRTIIVP--------------------- E_caballus_ENSECAP00000007300 ------------TST--VSKQRKNVIS--------CVTVHDSPYSDSSSN-TSPYSVQHRAGH-NANTFDTKG-S--------LEN-HCTGNPRTIIVP--------------------- P_troglodytes_ENSPTRP00000006052 LSTSS----SGQSSP--SPCKRPNSMS-DEEQESSCDTVDGSPTSDSSGH-DSPFAESTFVEDTHENTE---L-VSS------ADTE-TKPAVCSVVVP--------------------- P_pygmaeus_ENSPPYP00000003875 LSTSS----SGQSSP--SPCKRPNSMS-DEEQESGCDTVDGSPTSDSSGR-DSPFAESTFVEDTHENTE---L-VSS------ADTE-TKPAACSVVVP--------------------- G_gallus_ENSGALP00000002998 ------------ASL--GMKQRSNVIS--------YVTVNDSPDSDSSL--NSPYATDPLSSLRSTGGAL-EL-PS-------RGA-ADSSNSRTIIVP--------------------- G_gallus_ENSGALP00000019093 LSTSS----SGQSSP--SPCKRSNSMS-DDEQESGCDTVDGSPTSDSSGH-DSPFVEDGFVANTNKNKE---A-RAS------VNSE-TKSAVCTVVVP--------------------- H_sapiens_ENSP00000304226 LSTSS----SGQSSP--SPCKRPNSMS-DEEQESSCDTVDGSPTSDSSGH-DSPFAESTFVEDTHENTE---L-VSS------ADTE-TKPAVCSVVVP--------------------- M_domestica_ENSMODP00000012226 LSTSS----SDQSSP--SPGKRPNSMS-DDEQESGCDTVDGSPTSDSSGN-DSPFVESSFVEDSSQNTE---S-IAT------VDTE-TKPAVCTVVVP--------------------- A_carolinensis_ENSACAP00000002399 ------------GSL--GTKQRSNVIS--------YVTVNDSPDSDSSL--NSPYASNALSTLRSTGGAL-E--TG-------RVA-NDSSSSRTIIV---------------------- E_caballus_ENSECAP00000013135 ------------SSS--GLKARSNVIS--------YVTVNDSPDSDSSL--SSPYSTDTLSALRGNSGPLLEG-PG-------RVV-GDGTGTRTIIVP--------------------- C_familiaris_ENSCAFP00000013694 ------------SSS--GLKARSNVIS--------YVTVNDSPDSDSSL--SSPYSTDTLSALRGNSGSLVEG-PG-------RVV-GDGASTRTIIVP--------------------- C_familiaris_ENSCAFP00000010754 LSTSS----SGQSSP--SPCKRPNSMS-DEEQESGCDTVDGSPTSDSSGH-DSPFAESSFVEDAHQNTE---L-VTS------ANTE-TKPAVCTVVVP--------------------- E_caballus_ENSECAP00000018143 LSSSS----SGRPSP--SPCRRPSSMS-DEEQESGCDTVDGSPPSDSSGR-DSPFAERSFVEDTSRNAE---L-GTA------A--E-TKPAVCTVVVP--------------------- H_sapiens_ENSP00000358574 ------------SSS--GLKPRSNVIS--------YVTVNDSPDSDSSL--SSPYSTDTLSALRGNSGSVLEG-PG-------RVV-ADGTGTRTIIVP--------------------- P_troglodytes_ENSPTRP00000001943 ------------SSS--GLKPRSNVIS--------YVTVNDSPDSDSSL--SSPYSTDTLSALRGNSGSVLEG-PG-------RVV-ADGTGTRTIIVP--------------------- B_taurus_ENSBTAP00000015051 ------------NSS--GLKARSNVIS--------YVTVNDSPDSDSSL--SSPYSTETLSALRGNSGSLPEG-PG-------RVV-GDGPGTRTIIVP--------------------- T_guttata_ENSTGUP00000001607 ------------ASL--GMKQRSNVIS--------YVTVNDSPDSDSSL--SSPYAPDPLSSLRSTGGAL-EL-PS-------RAA-ADSSSSRTIIVP--------------------- M_musculus_ENSMUSP00000106754 LSTSS----SGQSSP--SPCKRPNSMS-DDEQESGCETVDGSPTSDSSGH-DSPFAENSFVEDAHQNTE---L-GTC------AGPE-AKPAVGTAVEP--------------------- B_taurus_ENSBTAP00000039475 LSTSS----SGQSSP--SPCKRPNSMS-DEEQESGCDTVDGSPTSDSSGH-DSPFAESSFVEDTHQNAE---L-VTS------TDTE-TKPAVCTVVVP--------------------- M_musculus_ENSMUSP00000113998 ------------NSS--SLKARSNVIS--------YVTVNDSPDSDSSL--SSPHPTDTLSALRGNSGTLLEG-PG-------RPA-ADGIGTRTIIVP--------------------- A_carolinensis_ENSACAP00000003036 LSTSS----SGQSSP--SPCKRPNSMS-DDEQESGCDTVDGSPSSDSSGH-DSPFLENGFAEDTAENPE---T-RTS------ANLE-AKPAVCTVVVP--------------------- R_norvegicus_ENSRNOP00000052927 ------------SSS--SLKARSNVIS--------YVTVNDSPDSDSSL--SSPYPTDTLSALRGNSGTLLEG-PG-------RTA-ADGIGTRTIIVP--------------------- O_anatinus_ENSOANP00000023838 LSTSS----SGQTSP--SPCKRPNSMS-DDEQESGCDTVDGSPTSDSSGH-DSPFAESRFAEDGHPNGD---S-LAS------ADQE-AKPAVCTVVVP--------------------- T_rubripes_ENSTRUP00000027188 ------------ASV--SLSQRTNVIS--------CVTVHDSDSST-----ASPLTPLPRTLNPASSASSRQA------------------RSLAVVAP--------------------- R_norvegicus_ENSRNOP00000015775 LSTSS----SGQSSP--SPCKRPNSMS-DDEQESGCETVDGSPTSDSSGH-DSPFAESSFVEDTPQNPE---L-GTC------AGTE-AKPALSTAVEP--------------------- D_rerio_ENSDARP00000083736 LSTSSSA--SEQSSA--SPCKRPNSMS-DDERESGCDTVDGSPASVSSSRADSPFLEATYINDNNQNCK---A-TGS------TETESAKLPVRTMVVP--------------------- G_aculeatus_ENSGACP00000017894 ------------SS---SSKQRKNVIS--------CVTVHDSPDSHCS---NSPYTLESRAPNNNNNSYDTK--TI-------LDN-YNNGNLRTIIVP--------------------- T_rubripes_ENSTRUP00000010045 LSTSSSA--SAHSSS--SPCKHPNSMS-DDEQESGCDTVDSSPPSNTSGHNSSPFIEQRYMAGSNQNCEPRVA-CVA------PETEPSKPTVRTVVVP--------------------- O_latipes_ENSORLP00000015420 LSTSSFASNSLQSSPSVSPCKRPNSMSEDDGHESGCDTVEGSPPSDAS---TSPRGNSAYRYLNNNNRPALAA-VVAPL-PSPTEQGRSPRGIRTMIVP--------------------- T_rubripes_ENSTRUP00000004224 LSTSSLASKSVQSSPSASPCKRANSMSEDEEQESGRNTVEGSPTSDARGN-------STYRYLDNNNLPPLPA-MAAAAPPSPAARRQSTRSVRTMVVP--------------------- P_pygmaeus_ENSPPYP00000020253 ------------TST--VSKQRKNVIS--------CVTVHDSPYSDSSSN-TSPYSVQQRAGHNNANAFDAKG-S--------LEN-HCTGNPRTIIVP--------------------- G_aculeatus_ENSGACP00000021106 LSTSSSA--SAQSST--SPCKHPNSMS-DDEQESCCDTVDSSPASNASGHSNSPFAQQRFIADGNHNREPRVA-CVA------PETEPSRPTVRTVVVP--------------------- G_gorilla_ENSGGOP00000003977 ------------TST--VSKQRKXVIS--------CVTVHDSPYSDSSSN-TSPYSVQQRAGHNNANAFDTKG-S--------LEN-HCTGNPRTIIVP--------------------- G_aculeatus_ENSGACP00000000924 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000494 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004833-PA ------------------------------------------------------------------------------------------------------------------------ 1810 1820 1830 1840 1850 1860 1870 1880 1890 1900 1910 1920 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0072450 -------------------------SIKYE----PGQSQK----------KRILAMAQS--ECGYQP------QVPSQPS------SSASLPHIPTKQEPAEFY-PEYAAAPPQQLDTKR A_gambiae_AGAP007342-PA SSSATACVTLGDSDGEGERRSPKHQPIKYEQ--HAGQSQK----------KRLLAMAQN--ECLLLP------SSSGSG-------GSQQPLHVP-KQEPSEFVAYEYPSQQQQQQVDKR A_aegypti_AAEL003731-PA -------------------------AIKYEH--HAGQSQK----------KRLLAMAQN--ECLLS--------------------SSTNQLHVP-KQEPTEFVAYEYP------QVDKR O_latipes_ENSORLP00000020125 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000029014 -------------------------PLKAQL--GDCTVAT------------QASGECL--KR---------YKVSGQSS------GCCITPTGYRAQRGGTN-------IAQPLNL--- M_domestica_ENSMODP00000017168 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000020840 -------------------------PLKIQN--GEVPSECERLMPGTDSMNHQNSSYKF--KS---S--NGVGSVNNHLP------GGVTGGGNYRQQRSGPHP-----LQQQPLNL--- D_rerio_ENSDARP00000062342 -------------------------PLKSQT--SENLGECDRLLP--DVMNHQNSTYKF--KT---S--NGGFSGNNHTS------GGVTGGGAYRQQRTGPHP-----FQQQPLNL--- T_guttata_ENSTGUP00000005223 -------------------------PMRLEN--RLHL-------------EEQMVNT----DAPCQPLRKGR-SVLGR--------INQSSVVGSRQQKLTSAF------HQHHGNF--- A_carolinensis_ENSACAP00000016703 -------------------------PLKTQA--SEVLVECDNLVPGKFAI-HHSSSYKS--KS---S--SIVTSTSGHSS------GSSSGAITYRQQRPGPHF-----QQQQPLNL--- C_familiaris_ENSCAFP00000006000 -------------------------PLKTQA--RQTKLFT------------QETGLLR--KR---I--YNVTSTSGHSS------GSSSGAIAYRQQRPGPHF-----QQQQPLNL--- X_tropicalis_ENSXETP00000003569 -------------------------PLKSQM--NDCPLDT------------QLTGVLS--GAAKIT--KSCTATNGQSS------S-CITQTGCRSHRM-LN-------GVQPLNL--- G_gallus_ENSGALP00000020844 -------------------------PLKTQA--SEVLVECDSLAPGTVTTSHHSSSYKS--KS---S--STVTSTSGHSS------GSSSGAVAYRQQRPGAHF-----QQQQPLNL--- T_nigroviridis_ENSTNIP00000022455 -------------------------PLKTQN--GQVASECERLMP--DSISHQNSSYKF--KS---S--NG-ASGNNHL----------TGGGSYRQQRSGAHP-----LQQQPLNL--- M_mulatta_ENSMMUP00000003337 -------------------------PLKTQA--SEVLVECDSLVP--VNTSHHSSSYKS--KS---S--SNVTSTSGHSS------GSSSGAITYRQQRPGPHF-----QQQQPLNL--- P_troglodytes_ENSPTRP00000033846 -------------------------PLKTQA--SEVLVECDSLVP--VNTSHHSSSYKS--KS---S--SNVTSTSGHSS------GSSSGAITYRQQRPGPHF-----QQQQPLNL--- H_sapiens_ENSP00000263551 -------------------------PLKTQA--SEVLVECDSLVP--VNTSHHSSSYKS--KS---S--SNVTSTSGHSS------GSSSGAITYRQQRPGPHF-----QQQQPLNL--- R_norvegicus_ENSRNOP00000010384 -------------------------PLKTQA--SEVLVECDSLGPA-ISTGHHSSSFKS--KS---S--STVTSTSGHSS------GSSSGAIAYRQQRPGPHF-----QQQQPLNL--- M_musculus_ENSMUSP00000045457 -------------------------PLKTQA--SEVLVECDSLGPA-ISASHHSSSFKS--KS---S--STVTSTSGHSS------GSSSGAIAYRQQRPGPHF-----QQQQPLNL--- T_guttata_ENSTGUP00000011747 -------------------------PLKTQA--SEVLVECDSLAP--VTTSHHSSSYKS--KS---S--STVTSTSGHSS------GSSSGAVAYRQQRPGAHF-----QQQQPLNL--- E_caballus_ENSECAP00000007300 -------------------------PLKTQA--SEVLVECDSLVP--VNTSHH-SSYKS--KS---S--SNVTSTSGHSS------GSSSGAVAYRQQRPGPHF-----QQQQPLNL--- P_troglodytes_ENSPTRP00000006052 -------------------------PVELEN--GLNA-------------DERMANT----DSICQPLIKGR-SAPGR--------LNQPSAVGTRQQKLTSAF------QQQHLNF--- P_pygmaeus_ENSPPYP00000003875 -------------------------PVELEN--GLNA-------------DEHMANT----DSICQPLIKGR-SAPGR--------LNQPSAVGTRQQKLTSAF------QQQHLNF--- G_gallus_ENSGALP00000002998 -------------------------PLKTQL--NDCIVAT------------QASGILSNTSK---T--KPVASVSGQSS------GCCITPTGYRPHRVVAN-------GVQPLNL--- G_gallus_ENSGALP00000019093 -------------------------PMSLEN--RLRL-------------DEQMVNT-E--DATCQPLKNGR-SVLGR--------KTQSSAVGNRQQKLASAF------HQQHLNF--- H_sapiens_ENSP00000304226 -------------------------PVELEN--GLNA-------------DEHMANT----DSICQPLIKGR-SAPGR--------LNQPSAVGTRQQKLTSAF------QQQHLNF--- M_domestica_ENSMODP00000012226 -------------------------PVRLEN--RLDS-------------DEQMAST----DSICQPLGKGR-SAPGR--------LNQSSAMSNRQQKLTTAS------QQQHLNF--- A_carolinensis_ENSACAP00000002399 -------------------------PLKTQL--SDCIVAT------------QASGVLSSLNK---T--KPVASVNGQTS------GCCITPTGYRQHRVVTN-------GVQPLNL--- E_caballus_ENSECAP00000013135 -------------------------PLKTQL--GDCTVAT------------QASGLLS--SK---T--KPVASVSGQSS------GCCITPTGYRAQRGGTS-------AAQPLNL--- C_familiaris_ENSCAFP00000013694 -------------------------PLKTQL--GDCTVAT------------QASGLLS--SK---T--KPVASVSGQSS------GCCITPTGYRVPRGGTS-------AAQPLNL--- C_familiaris_ENSCAFP00000010754 -------------------------PMGLEN--GLNA-------------DEHMSNT----DSICQPLIKGR-SAPGR--------LNQPSTVGNRQQKLTSAF------QQQHLNF--- E_caballus_ENSECAP00000018143 -------------------------PLGLEN--GLNA-------------EEHMANT----DSICQPLIKGR-SAPGR--------LNQPSTAGNRQPKLTSAF------QQQPLNF--- H_sapiens_ENSP00000358574 -------------------------PLKTQL--GDCTVAT------------QASGLLS--NK---T--KPVASVSGQSS------GCCITPTGYRAQRGGTS-------AAQPLNL--- P_troglodytes_ENSPTRP00000001943 -------------------------PLKTQL--GDCTVAT------------QASGLLS--NK---T--KPVASVSGQSS------GCCITPTGYRAQRRGTS-------AAQPLNL--- B_taurus_ENSBTAP00000015051 -------------------------PLKTQL--GDCTVAT------------QASGLLS--SK---T--KPVASVSGQSS------GCCITPTGYRAQRGGTS-------AAQPLNL--- T_guttata_ENSTGUP00000001607 -------------------------PLKMQL--NDCIVAT------------QASGGLR--CS---P--VPVTHSSLQEE------GCLARGSGYRGQRAGEE-------SVQPLRG--- M_musculus_ENSMUSP00000106754 -------------------------PVGRES--GLSV-------------DEHMANT----DSTCQPLRKGQ-PAPGK--------LHQPPALGARQQKPAAAF------PQQHLNL--- B_taurus_ENSBTAP00000039475 -------------------------PMGLEN--GLNA-------------DEHMANT----DSICQPLIKGR-SAPGR--------LNQPSTVGNRQQKSTSAF------QQQHLNF--- M_musculus_ENSMUSP00000113998 -------------------------PLKTQL--GDCTVAT------------QASGLLS--SK---T--KPVASVSGQSS------GCCITPTGYRAQRGGAS-------AVQPLNL--- A_carolinensis_ENSACAP00000003036 -------------------------PMRIQN--RLNA-------------DAQITNA----VNTCQPLVKRR-PTRVK--------MNHPSGFGNRQRKLASAF------HQQHSNL--- R_norvegicus_ENSRNOP00000052927 -------------------------PLKTQL--GDCTGAT------------QASGLLSS-SK---T--KPVASVSGQSS------GCCITPTGYRAQRGGAS-------AVQPLNL--- O_anatinus_ENSOANP00000023838 -------------------------PMRIEN--RLNA-------------DEQMANT----DPACQPLIKGR-SAPGR--------LNQPSAVGNRQQKLTSAF------QQQHLNF--- T_rubripes_ENSTRUP00000027188 -------------------------SVKTQG--SDRGAVS------------HLENGTV-------NYVKPKRSSNRQ-----------PCSSGESMECPGLVP-----SQSHPLNL--- R_norvegicus_ENSRNOP00000015775 -------------------------PVGTER--GLNV-------------DAHMANT----DSTCQPLTKGQ-PAPGK--------LNQPSASAARQQKPTSAF------QQQHLNL--- D_rerio_ENSDARP00000083736 -------------------------PMRVQN--------------------EPVGRTVI--EPSCPP--KGR-SGSNRQ-------LPYSTLLVNRQQKSTPAFPPLQPPQQQL--F--- G_aculeatus_ENSGACP00000017894 -------------------------PLKTQS--SEAPNECERLMP--EPMTHQNSAYKF--KS---S--NGLASGNNHLH------GGLTGGGSYRQQRSGLHA-----LQQQPLNL--- T_rubripes_ENSTRUP00000010045 -------------------------PMRVHNSNNNHPAMT----------SDTSGNTVL--ESSCHS--KGR-VIPGRQ-------HHHTTPLLNRQQKIAPAF---QPQQQQPLGF--- O_latipes_ENSORLP00000015420 -------------------------PMRVQS--NNRNSRG---------TEERAQRTIS--ESWSRS--KGRCNLVGQQSTPSSVPLLPSAPLLSRQQKVAGQQ------QQHPLGF--- T_rubripes_ENSTRUP00000004224 -------------------------PMPLQN--NNSQG-----------TEEPAQRAAS--ASWSQS--KGRCSLPGQHGVPSSVPLFASAPHLPRQQKVGGQ-------QLHSLGF--- P_pygmaeus_ENSPPYP00000020253 -------------------------PLKTQA--SEVLVECDSLVP--VNTSHHSSSYKS--KS---S--SNVTSTSGHSS------GSSSGAITYRQQRPGPHF-----QQQQPLNL--- G_aculeatus_ENSGACP00000021106 -------------------------PMRVHN--NNYPAV-----------SEAYGHS----ESICLS--KGW-GLPGRH-------HHQSTPLLNRPQKMPPAF---QPQQQQPIGF--- G_gorilla_ENSGGOP00000003977 -------------------------PLKTQA--SEVLVECDSLVP--XXXXXXXXXXXX--XX---X--XXXXXXXXXXX------XXXXXXXXXXXXXXXXXX-----XXXXXXXX--- G_aculeatus_ENSGACP00000000924 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000494 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004833-PA ------------------------------------------------------------------------------------------------------------------------ 1930 1940 1950 1960 1970 1980 1990 2000 2010 2020 2030 2040 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0072450 SSWAPTSSGSGVSALPLA-------------HPKREAPSVAPISYVAPSVAPPLAHSKSSSASSSSSISAATAAAAAAAAAAAASVGPPSWGPPQVYRQPSQPPPGSVGLPGSTQPPPSS A_gambiae_AGAP007342-PA SSWAPPTMGSSSSSSHYG--G-------G--GHKRESSSYIPSSSA--SSSSSLAAATAAAAAAAAAAIQQQQHQGGGSGGGGCSGGSLGHAPPPHAHAKSTPT----G--ATSWGPPTA A_aegypti_AAEL003731-PA SSWAPP-----GSSSHYG--GGHNSSSSG--GHKRESSAYMPSSSS--SS---------------SSVNQGSSSMGGGPMGGGSSLG----AAPPHAHAKNTPT----GGSGSSWGAPV- O_latipes_ENSORLP00000020125 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000029014 -----------SQVSIKA--PSLQERS-SNPAPRRQQA-FVAPL----SQAPYT-FQHGSPL-H-STGH---PHLAPAP---AHLPSQP--------HLYTYAAPTSAAAL-GSTSSIAH M_domestica_ENSMODP00000017168 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000020840 -----------SHAQQHM----IAERN-G--GHRRQQA-YIAPTIA--AQAPYS-FHHNSPS-HTGNVH---PHL-----AATHLPSQP--------HLYTYTAP---AAL-GSTGTVAH D_rerio_ENSDARP00000062342 -----------SQAQQHM----AVERN-G--GHRRQQA-YITPTMA--TQAQYS-F-HNSPT-HTANVH---PHL-----AAPHLPGQP--------HLYTYTAP---AAL-GSTGTVAH T_guttata_ENSTGUP00000005223 -----------SQLQVFS--SLIEEWN-GNFAPRRQQH-HQHHQHQ--QQ-HQQ-QHQQQPFLP-GPAP---SHLP----GGSQLGGQP--------TILPFASP---AP------PVPH A_carolinensis_ENSACAP00000016703 -----------SQVQQHI----TTDRT-G--SHRRQQA-YIAPTIA---QAPYS-FPHNSPS-H-GTVH---PHL-AAA-AAAHLPTQP--------HLYTYTAP---AAL-GSTGTVAH C_familiaris_ENSCAFP00000006000 -----------SQAQQHI----TAERA-G--SHRRQQA-YITPTMA---QAPYS-FPHNSPS-H-GTVH---PHLAAAA-AAAHLPAQP--------HLYTYTAP---AAL-GSTGTVAH X_tropicalis_ENSXETP00000003569 -----------SQNQQSAMMG-TQERS-MNPGSRRQQA-YVAPLPS-ISQAPFT-FQHSSPL-H-STVH---PHLAAAATATSHLTSQP--------HMYTY-APTTAASL-GSTTSIAH G_gallus_ENSGALP00000020844 -----------SQAQQHI----TTDRT-G--SHRRQQA-YITPTIA---QAPYS-FPHNSPS-H-GTVH---PHL-AAA-AAAHLPTQP--------HLYTYTTP---AAL-GSTGTVAH T_nigroviridis_ENSTNIP00000022455 -----------SQAQQHM----VAERN-G--GHRRQQA-YIAPTIA--AQAPYS-FHHNSPS-HTGNVH---PHL-----AATHLPSQP--------HLYTYTAP---AAL-GSTGTVAH M_mulatta_ENSMMUP00000003337 -----------SQAQQHI----TADRT-G--GHRRQQA-YITPTMA---QAPYS-FPHNSPS-H-GTVH---PHLAAAA-AAAHLPTQP--------HLYTYTAP---AAL-GSTGTVAH P_troglodytes_ENSPTRP00000033846 -----------SQAQQHI----TADRT-G--SHRRQQA-YITPTMA---QAPYS-FPHNSPS-H-GTVH---PHLAAAA-AAAHLPTQP--------HLYTYTAP---AAL-GSTGTVAH H_sapiens_ENSP00000263551 -----------SQAQQHI----TTDRT-G--SHRRQQA-YITPTMA---QAPYS-FPHNSPS-H-GTVH---PHLAAAA-AAAHLPTQP--------HLYTYTAP---AAL-GSTGTVAH R_norvegicus_ENSRNOP00000010384 -----------SQAQQHM----AADRT-G--SHRRQQA-YITPTMA---QAPYT-FPHSSPS-H-GTVH---PHL---A-AAAHLPAQP--------HLYTYTAP---TAL-GSTSTVAH M_musculus_ENSMUSP00000045457 -----------SQAQQHM----AADRT-G--SHRRQQA-YITPTMA---QAPYT-FPHNSPS-H-GTVH---PHL---A-AAAHLPTQP--------HLYTYTAP---TAL-GSTGTVAH T_guttata_ENSTGUP00000011747 -----------SQGQQHI----STDRT-G--SHRRQQA-YITPTIA---QAPYS-FPHNSPS-H-GTVH---PHL-AAA-AAAHLPTQP--------HLYTYTAP---AAL-GSTGTVAH E_caballus_ENSECAP00000007300 -----------SQAQQHI----TADRA-G--SHRRQQA-YITPTMA---QAPYS-FPHNSPS-H-GAVH---PHL---A-AAAHLPTQP--------HLYTYTAP---AAL-GSTGTVAH P_troglodytes_ENSPTRP00000006052 -----------SQVQHFG--SGHQEWN-GNFGHRRQQA-YIPTSVT--SN-PFT-LSHGSPN-H-TAVH---AHLA----GNTHLGGQP--------TLLPYPSS---ATL-SSAAPVAH P_pygmaeus_ENSPPYP00000003875 -----------SQVQHFG--SGHQEWN-GNFGHRRQQA-YIPTSVT--SN-PFT-LSHGSPN-H-TAVH---AHLA----GNTHLGGQP--------TLLPYPSS---ATL-SSAAPVAH G_gallus_ENSGALP00000002998 -----------SQNQQTTVLA-SQERS-GNAVPRRQQA-YVAPLTSTISQAPYT-FQHSSPV------H---PHLAAAT-ANAHLSSQP--------HMYTY-APTTAATL-GSTTSIAH G_gallus_ENSGALP00000019093 -----------SQVQHFG--SAPQEWN-GNYAHRRQQA-YIPASVA--SH-AFS-LPQGSPN-P-TTVH---AHLS----GSTHLGGQP--------AILPYPSS---APL-STAAPVAH H_sapiens_ENSP00000304226 -----------SQVQHFG--SGHQEWN-GNFGHRRQQA-YIPTSVT--SN-PFT-LSHGSPN-H-TAVH---AHLA----GNTHLGGQP--------TLLPYPSS---ATL-SSAAPVAH M_domestica_ENSMODP00000012226 -----------SQVQHFG--SGHQEWN-GNYGHRRQQA-YVPATVS--SH-PFA-LSQGSPN-H-TAVR---APLA----GTTPRAGQP--------ALLPYPPA---APL-ATAAPVTH A_carolinensis_ENSACAP00000002399 -----------SQNQQATVLS-SQERS-GNPAPRRQQA-YVAPLPTTIAQAPYT-FQHSSPV------H---PHLAAAT-A-----SQP--------HMYTY-APTTAATL-GSTNSIAH E_caballus_ENSECAP00000013135 -----------SQNQQSSSAPTSQERS-SNPAPRRQQA-FVAPL----SQAPYA-FQHGSPL-H-STGH---PHLAPAP---AHLPSQP--------HLYTYAAPTSAAAL-GSTSSIAH C_familiaris_ENSCAFP00000013694 -----------SQNQQSSSASTSQERS-SNPAPRRQQA-FVAPL----SQAPYT-FQHGSPL-H-STGH---PHLAPAP---AHLPSQP--------HLYTYAAPTSAAAL-GSTSSIAH C_familiaris_ENSCAFP00000010754 -----------SQVQHFG--SGHQEWN-GNFGHRRQQA-YIPTSVT--SN-PFT-LSHGSPN-H-TAVH---AHLA----GSAHLGGQP--------TLLPYPSS---ATL-SSAAPVAH E_caballus_ENSECAP00000018143 -----------SQVQHFG--SGHQEWN-GNFGHRRQQA-YIPTSVT--SN-PFT-FSHGSPS-H-TTVH---AHLA----GNTHLGGQP--------TLLPYPSS---AAL-SSAAPVAH H_sapiens_ENSP00000358574 -----------SQNQQSSAAPTSQERS-SNPAPRRQQA-FVAPL----SQAPYT-FQHGSPL-H-STGH---PHLAPAP---AHLPSQA--------HLYTYAAPTSAAAL-GSTSSIAH P_troglodytes_ENSPTRP00000001943 -----------SQNQQSSAAPTSQERS-SNPAPRRQQA-FVAPL----SQAPYT-FQHGSPL-H-STGH---PHLAPAP---AHLPSQA--------HLYTYAAPTSAAAL-GSTSSIAH B_taurus_ENSBTAP00000015051 -----------SQNQQSSSAPTSQERS-SNPAPRRQQA-FVAPL----SQAPYA-FQHGSPL-H-STGH---PHLAPAP---AHLPSQP--------HLYTYAAPTSAAAL-GPTTSIAH T_guttata_ENSTGUP00000001607 -----------EGNQQTTVLA-SQERN-GNAVPRRQQA-YVAPLTSTISQAPYT-FQHSSPV------H---PHLAAAT-ASAHLPSQP--------HMYTY-APSTAATL-GSTTSIAH M_musculus_ENSMUSP00000106754 -----------SQVQHFG--TGHQEWN-GNFGHRRQQA-YIPTSVT--SN-PFT-LSHGSPN-H-TAVH---AHLA----GSTHLGGQP--------TLLPYPSS---ASL-SSAAPVAH B_taurus_ENSBTAP00000039475 -----------SQVQHFG--SGHQEWN-GNFGHRRQQA-YIPTSVT--SN-PFT-LSHGSPN-H-TAVH---AHLA----ASAHLGGQP--------TLLPYPSS---APL-SSAAPVAH M_musculus_ENSMUSP00000113998 -----------SQNQQSSSASTSQERS-SNPAPRRQQA-FVAPL----SQAPYA-FQHGSPL-H-STGH---PHLAPAP---AHLPSQP--------HLYTYAAPTSAAAL-GSTSSIAH A_carolinensis_ENSACAP00000003036 -----------SQVQHFG--GGTQEWN-GNCGHWRQQT-YIPANVA--SH-AFS-IQHGSPT-H-SSVH---AHLA----GSTHLGGQP--------ALLPYPSS---APL-STAAPVAH R_norvegicus_ENSRNOP00000052927 -----------SQNQQSSSASTSQERS-SNPAPRRQQA-FVAPL----SQAPYA-FQHGSPL-H-STGH---PHLAPAP---AHLPSQP--------HLYTYAAPTSAAAL-GSTSSIAH O_anatinus_ENSOANP00000023838 -----------SQVQHFG--SGPQEWN-GNYGHRRQPA-YIAATVA--ANHPFP-LSHGSPN-H-PTVH---AHLA----GSAPLGGQP--------ALLPYPPS---APL-STTAPVAH T_rubripes_ENSTRUP00000027188 -----------SQVQPVV--SSSQERSKSDLSLRRQQT-FPPAA----SASHYN-FPEVSSL------------------APASAPG-P--------SLYTYPAS---TAL-TSASQAME R_norvegicus_ENSRNOP00000015775 -----------SQVQHFG--TGHQEWN-GNLGHRRQQA-YIPTSVT--SN-PFT-LSHGSPN-H-TAVH---AHLA----GSAHLGGQP--------TLLPYPPS---TAL-SSAAPVAH D_rerio_ENSDARP00000083736 -----------GQVQHYG--SSHQEWN-GNYSHRRPQA-FIPPTVH--SH-TFT-LPHGSPT-H-TTHP-PQSHLG----VHPH--TQP--------ALLSYPPS---GPL-VTNAPMAH G_aculeatus_ENSGACP00000017894 -----------SQAQQHM----ANERN----GHRRQQA-YITPTIA--TQPPYS-FHHNSPS-HAGNVH---PHL-----AATHLPGQP--------HLYTYTAP---AAL-GSTGTVAH T_rubripes_ENSTRUP00000010045 -----------GQVHHYG--SCHQEWN-GNFTHRRPQA-YIPPTMH--GH-TFA-LSHSSPN-H-TAGPH--PHLG----GHPH--SQP--------TLLSYPPS---GSL-VTAAPVAH O_latipes_ENSORLP00000015420 -----------GQVRLLPVLHP--------FSYRQMHVKLVPLSIT--LN-PYQILPESSRF-S-KTLK-----------NQLHADLDR--------ANVTSPIE---SGL-LLAPNEVH T_rubripes_ENSTRUP00000004224 -----------GQVQLFLPNHPNKDWN-RNYGPLRPHA-YIPPTVH--TH-TFPHLPHGSPT-H-TSAA-----------PPAHPQGLPPH------TLLSYQST---GALAATHHPTQS P_pygmaeus_ENSPPYP00000020253 -----------SQAQQHI----TADRT-G--SHRRQQA-YITPTMG---QAPYS-FPHNSPS-H-GAVH---PHLAAAA-AAAHLPTQP--------HLYTYTAP---AAL-GSTGTVAH G_aculeatus_ENSGACP00000021106 -----------GQVQHFG--SCHQEWN-GNFAHRRPQA-YIPPTMH--GH-TFT-LSHSSPN-H-TTGPHPLPHLG----GHPH--TQP--------TLLSYPPS---GPL-VTAAPVAH G_gorilla_ENSGGOP00000003977 -----------XXAQQHI----TADRT-G--SHRRQQA-YITPTMA---QAPYS-FPHNSPS-H-GTVH---PHLAAAA-AAAHLPTQP--------HLYTYTAP---AAL-GSTGTVAH G_aculeatus_ENSGACP00000000924 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000494 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004833-PA ------------------------------------------------------------------------------------------------------------------------ 2050 2060 2070 2080 2090 2100 2110 2120 2130 2140 2150 2160 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0072450 VAPHPHHHSHGHHHHQAGTPLGGSPSSTA----AAALLQPDIYAQG-DIYRRPTVFVSQAAPSYAYANRAVVAPPPAHN-----------SSSR-------------------------- A_gambiae_AGAP007342-PA AV-------YRQHQPSANTPLGSSPGAILQQHQHQAQQQQDMYAQG-DMYRRSAVFVSQAAPYQTAYNR--VVPPPAHN-----------ASSRQVRKTPLSTSSPYASKDSTTSTERFP A_aegypti_AAEL003731-PA ---------YRQHQQSSNTPLGSSPGAML--------QQQDIYAQG-DIYRRSAVFVSQ-APYQT-YNR--VVPPPAHN-----------ASSR-------------------------- O_latipes_ENSORLP00000020125 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000029014 LF--------------------SPQGSSR--HTAAY----TTHPST--LVHQVPVSVGP---------S--LLTSASVAP----------AQYQ-------------------------- M_domestica_ENSMODP00000017168 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000020840 LV--------------------ASQGSAR--HAVQH----GSYPPS--LVHQVPVSMGH---------R--VLPSPSLHQ----------SQYQ-------------------------- D_rerio_ENSDARP00000062342 LV--------------------ASQGSAR--HAVQH----ASYPPG--IVHQVPVSMGH---------R--VLPSPTLHH----------GQYQ-------------------------- T_guttata_ENSTGUP00000005223 LL--------------------ASPCASR--ALLQRPAFGLGHAGG--VVRQLPVGIDP---------R--LLPSPSVH-Q---------TQYK-------------------------- A_carolinensis_ENSACAP00000016703 LV--------------------ASQGSAR--HTVQH----ATYPAS--IVHQVPVSMGP---------R--VLPSPTIHP----------SQYQ-------------------------- C_familiaris_ENSCAFP00000006000 LV--------------------ASQGSAR--HTVQH----TAYPAS--IVHQVPVSMGP---------R--VLPSPTIHP----------SQYP-------------------------- X_tropicalis_ENSXETP00000003569 LF--------------------SPQGSSR--H-TTF----ATHPST--LVHQVPVSVGP---------S--LLTSANVAS----------AQYP-------------------------- G_gallus_ENSGALP00000020844 LV--------------------ASQGSAR--HAVQH----TTYPAS--IVHQVPVSMGP---------R--VLPSPTIHP----------SQYQ-------------------------- T_nigroviridis_ENSTNIP00000022455 LV--------------------ASQGSAR--HAVQH----GSYPPS--LVHQVPVSMGH---------R--VLPSPTLHH----------SQYQ-------------------------- M_mulatta_ENSMMUP00000003337 LV--------------------ASQGSAR--HTVQH----TAYPAS--IVHQVPVSMGP---------R--VLPSPTIHP----------SQYP-------------------------- P_troglodytes_ENSPTRP00000033846 LV--------------------ASQGSAR--HTVQH----TAYPAS--IVHQVPVSMGP---------R--VLPSPTIHP----------SQYP-------------------------- H_sapiens_ENSP00000263551 LV--------------------ASQGSAR--HTVQH----TAYPAS--IVHQVPVSMGP---------R--VLPSPTIHP----------SQYP-------------------------- R_norvegicus_ENSRNOP00000010384 LV--------------------ASQGSAR--HTVQH----TAYPAS--IVHQVPVSMGP---------R--VLPSPTIHP----------SQYP-------------------------- M_musculus_ENSMUSP00000045457 LV--------------------ASQGSAR--HTVQH----TAYPAS--IVHQVPVSMGP---------R--VLPSPTIHP----------SQYP-------------------------- T_guttata_ENSTGUP00000011747 LV--------------------ASQGSAR--HAVQH----TTYPAS--IVHQVPVSMGP---------R--VLPSPTIHP----------SQYQ-------------------------- E_caballus_ENSECAP00000007300 LV--------------------ASQGSAR--HTVQH----TAYPAS--IVHQVPVSMGP---------R--VLPSPTIHP----------SQYP-------------------------- P_troglodytes_ENSPTRP00000006052 LL--------------------ASPCTSR--PMLQHPTYNISHPSG--IVHQVPVGLNP---------R--LLPSPTIH-Q---------TQYK-------------------------- P_pygmaeus_ENSPPYP00000003875 LL--------------------ASPCTSR--PMLQHPTYNISHPSG--IVHQVPVGLNP---------R--LLPSPTIH-Q---------TQYK-------------------------- G_gallus_ENSGALP00000002998 LF--------------------SPQGSSR--H-TQY----AAHPST--LVHQVPVSVGP---------S--LLTSANVPP----------AQYQ-------------------------- G_gallus_ENSGALP00000019093 LL--------------------ASPCTSR--PLLQHPTYNISHPSG--IVHQVPVGINP---------R--LLPSPTIH-Q---------TQYK-------------------------- H_sapiens_ENSP00000304226 LL--------------------ASPCTSR--PMLQHPTYNISHPSG--IVHQVPVGLNP---------R--LLPSPTIH-Q---------TQYK-------------------------- M_domestica_ENSMODP00000012226 LL--------------------ASPCTSR--PILQHPAYSISHPNG--IVHQVPVGINP---------R--LLPSPTIH-Q---------TQYK-------------------------- A_carolinensis_ENSACAP00000002399 LF--------------------SPQGSSR--H-TAY----TTHPST--LVHQVPVSVGP---------S--LLTSANVAP----------AQYQ-------------------------- E_caballus_ENSECAP00000013135 LF--------------------SPQGSSR--HAAAY----TTHPST--LVHQVPVSVGP---------S--LLTSASVAP----------AQYQ-------------------------- C_familiaris_ENSCAFP00000013694 LF--------------------SPQGSSR--HAAAY----STHPST--LVHQVPVSVGP---------S--LLTSASVAP----------AQYQ-------------------------- C_familiaris_ENSCAFP00000010754 LL--------------------ASPCTSR--PMLQHPTYNISHPSG--IVHQVPVGINP---------R--LLPSPTIH-Q---------TQYK-------------------------- E_caballus_ENSECAP00000018143 LL--------------------ASPCTSR--PVLQHPSYNISHPSG--IVHQVPMGINP---------R--LLPSPTIH-Q---------TQYK-------------------------- H_sapiens_ENSP00000358574 LF--------------------SPQGSSR--HAAAY----TTHPST--LVHQVPVSVGP---------S--LLTSASVAP----------AQYQ-------------------------- P_troglodytes_ENSPTRP00000001943 LF--------------------SPQGSSR--HAAAY----TTHPST--LVHQVPVSVGP---------S--LLTSASVAP----------AQYQ-------------------------- B_taurus_ENSBTAP00000015051 LF--------------------SPQGSSR--HAAAY----ATHPST--LVHQVPVSVGP---------S--LLTSASVAP----------AQYQ-------------------------- T_guttata_ENSTGUP00000001607 LF--------------------SPQGSSR--H-TTY----AAHPST--LVHQVPVSVGP---------S--LLTSANVPP----------AQYQ-------------------------- M_musculus_ENSMUSP00000106754 LL--------------------ASPCTSR--PMLQHPTYNISHPSG--IVHQVPVGINP---------R--LLPSPTIH-Q---------TQYK-------------------------- B_taurus_ENSBTAP00000039475 LL--------------------ASPCTSR--PMLQHPTYNISHPSG--IVHQVPVGINP---------R--LLPSPTIH-Q---------TQYK-------------------------- M_musculus_ENSMUSP00000113998 LF--------------------SPQGSSR--HAAAY----TTHPST--LVHQVPVSVGP---------S--LLTSASVAP----------AQYQ-------------------------- A_carolinensis_ENSACAP00000003036 IL--------------------ASPCTSR--PILQHPTYSISHHGG--LVHQVPVGINP---------R--LLPSPTIH-Q---------THYK-------------------------- R_norvegicus_ENSRNOP00000052927 LF--------------------SPQGSSR--HAAAY----TTHPST--LVHQVPVSVGP---------S--LLTSASVAP----------AQYQ-------------------------- O_anatinus_ENSOANP00000023838 LL--------------------ASPCTSR--PLLQHPAYSISHPGG--LVHQVPVGINP---------R--LLASPTIH-R---------TPYK-------------------------- T_rubripes_ENSTRUP00000027188 QL--------------------LGRGHAG--HGHSPSAYAATYTSS--SSRRDSASRKE-------------SVSSLLHS--------LPAAFQ-------------------------- R_norvegicus_ENSRNOP00000015775 LL--------------------ASPCTSR--PMLQHPTYNISHPSG--IVHQVPVGINP---------R--LLPSPTIH-Q---------TQYK-------------------------- D_rerio_ENSDARP00000083736 LL--------------------ASPGATR--NHVFQPAYGLSHPAG-HLLHQVTVGIN----------R--LLPSPTIHPQ---------GQFK-------------------------- G_aculeatus_ENSGACP00000017894 LV--------------------ASQGSAR--HAVQH----GSYPPS--IVHQVPVSMGH---------R--VLPSPTLHH----------GQYQ-------------------------- T_rubripes_ENSTRUP00000010045 LL--------------------PSPVASR--PPVLQPPYNLSHPAG--IMHQVTVGINP---------R--FLPSPTLHPQ---------GQFK-------------------------- O_latipes_ENSORLP00000015420 SV--------------------AIFARSKHCPALQH-SYGLSHPQGGALVHQVTLGIAPHHPGHPAPHR--LLPSPTIHPHHQPGYAHHPHQFK-------------------------- T_rubripes_ENSTRUP00000004224 IL--------------------PPPP-----PLVQH-GYGLSHPQGGAIVHQVTLGISA---HPHHPHR--LLPSPTVHPHHQPSYGPLPHQFK-------------------------- P_pygmaeus_ENSPPYP00000020253 LV--------------------ASQGSAR--HTVQH----TAYPAS--IVHQVPVSMGP---------R--VLPSPTIHP----------SQYP-------------------------- G_aculeatus_ENSGACP00000021106 LL--------------------ASPVASR---PVLQPTYSISHPAG--IVHQVTVGLNH---------R--LLPSPTLHPQ---------GPFK-------------------------- G_gorilla_ENSGGOP00000003977 LV--------------------ASQGSAR--HTVQH----TAYPAS--IVHQVPVSMGP---------R--VLPSPTIHP----------SQYP-------------------------- G_aculeatus_ENSGACP00000000924 -----------------------------------------------------------------------VLP---------------------------------------------- G_aculeatus_ENSGACP00000000494 -----------------------------------------------------------------------VLP---------------------------------------------- A_gambiae_AGAP004833-PA ------------------------------------------------------------------------------------------------------------------------ 2170 2180 2190 2200 2210 =========+=========+=========+=========+=========+======= D_melanogaster_FBpp0072450 ----QVI----PSHPLPAHIQIPT-QYSQFGPLSPAQVAASKHAAHFAPTNIWYGAE A_gambiae_AGAP007342-PA SFPLQVL----PTHPLPAHIQFPTAQYGQFGPLSPAQIANKHHYAWFG--------E A_aegypti_AAEL003731-PA ----QVL----PTHPLPAHIQFPT-QYSQFGPLSPAQIANKHF--WFN--------E O_latipes_ENSORLP00000020125 --------------------------------------------------------- M_domestica_ENSMODP00000029014 ----QQF----ATQS-YIGSSRGSTIYTGY-PLSPTKISQYSY-------------L M_domestica_ENSMODP00000017168 --------------------------------------------------------- T_rubripes_ENSTRUP00000020840 ----AQF----AHQA-YISASPASTVYTGY-PLSPTKVNQYPY-------------L D_rerio_ENSDARP00000062342 ----AQF----AHQT-YISASP---VYTGY-PLSPTKMNQYPY-------------L T_guttata_ENSTGUP00000005223 ----ALF----PPHP-YVAASP--AAYAGF-PLSPTKLSQYPF-------------M A_carolinensis_ENSACAP00000016703 ----AQF----AHQT-YISASPAS-VYTGY-PLSPAKVNQYPY-------------I C_familiaris_ENSCAFP00000006000 ----AQF----AHQT-YISASPASTVYTGY-PLSPAKVNQYPY-------------I X_tropicalis_ENSXETP00000003569 ----HQF----AAQS-YIGASRGSAIYTGY-PLSPTNINQYSY-------------L G_gallus_ENSGALP00000020844 ----AQF----AHQT-YISASPASTVYTGY-PLSPTKVNQYPY-------------I T_nigroviridis_ENSTNIP00000022455 ----AQF----AHQA-YISASPASTVYTGY-PLSPTKVNQYPY-------------L M_mulatta_ENSMMUP00000003337 ----AQF----AHQT-YISASPASTVYTGY-PLSPAKVNQYPY-------------I P_troglodytes_ENSPTRP00000033846 ----AQF----AHQT-YISASPASTVYTGY-PLSPAKVNQYPY-------------I H_sapiens_ENSP00000263551 ----AQF----AHQT-YISASPASTVYTGY-PLSPAKVNQYPY-------------I R_norvegicus_ENSRNOP00000010384 ----AQF----AHQT-YISASPASTVYTGY-PLSPAKVNQYPY-------------I M_musculus_ENSMUSP00000045457 ----AQF----AHQT-YISASPASTVYTGY-PLSPAKVNQYPY-------------I T_guttata_ENSTGUP00000011747 ----AQF----AHQT-YISASPASTVYTGY-PLSPTKVNQYPY-------------I E_caballus_ENSECAP00000007300 ----AQF----AHQT-YISASPASTVYTGY-PLSPAKVNQYPY-------------I P_troglodytes_ENSPTRP00000006052 ----PIF----PPHS-YIAASP---AYTGF-PLSPTKLSQYPY-------------M P_pygmaeus_ENSPPYP00000003875 ----PIF----PPHS-YIAASP---AYTGF-PLSPTKLSQYPY-------------M G_gallus_ENSGALP00000002998 ----HQF----APQS-YIGASRGSAIYTGY-PLSPTKINQYSY-------------L G_gallus_ENSGALP00000019093 ----PIF----PPHS-YIAASP---AYTGF-PLSPTKLSQYPF-------------M H_sapiens_ENSP00000304226 ----PIF----PPHS-YIAASP---AYTGF-PLSPTKLSQYPY-------------M M_domestica_ENSMODP00000012226 ----PIF----PPHS-YIAASP---TYTGF-PLSPTKLSQYPY-------------M A_carolinensis_ENSACAP00000002399 ----HQF----ATQS-YIGASRGSAIYTGY-PLSPTKINQYSY-------------L E_caballus_ENSECAP00000013135 ----HQF----ATQS-YIGSSRGSAIYTGY-PLSPTKISQYSY-------------L C_familiaris_ENSCAFP00000013694 ----HQF----ATQS-YIGSSRGSTIYTGY-PLSPTKISQYSY-------------L C_familiaris_ENSCAFP00000010754 ----PIF----PPHS-YIAASP---AYTGF-PLSPTKLSQYPY-------------M E_caballus_ENSECAP00000018143 ----PIF----PPHS-YITASP---AYTGF-PLSPTKLSQYPY-------------M H_sapiens_ENSP00000358574 ----HQF----ATQS-YIGSSRGSTIYTGY-PLSPTKISQYSY-------------L P_troglodytes_ENSPTRP00000001943 ----HQF----ATQS-YIGSSRGSTIYTGY-PLSPTKISQYSY-------------L B_taurus_ENSBTAP00000015051 ----HQF----ATQS-YIGSSRGSTIYTGY-PLSPTKISQYSY-------------L T_guttata_ENSTGUP00000001607 ----HQF----APQS-YIGASRGSAIYTGY-PLSPTKINQYSY-------------L M_musculus_ENSMUSP00000106754 ----PIF----PPHS-YIAASP---AYTGF-PLSPTKLSQYPY-------------M B_taurus_ENSBTAP00000039475 ----PIF----PPHS-YIAASP---AYTGF-PLSPTKLSQYPY-------------M M_musculus_ENSMUSP00000113998 ----HQF----ATQS-YIGSSRGSTIYTGY-PLSPTKISQYSY-------------L A_carolinensis_ENSACAP00000003036 ----PIF----PPHS-YI-ASP---AYTGF-PLSPTKLSQYPF-------------L R_norvegicus_ENSRNOP00000052927 ----HQF----ATQS-YIGSSRGSTIYTGY-PLSPTKISQYSY-------------L O_anatinus_ENSOANP00000023838 ----PIF----PPHP-YITASP---AYTGF-PLSPTKLSQYPY-------------M T_rubripes_ENSTRUP00000027188 ----HQF----ATASPYVSVTPRAEAYSAY-QLSPRRLTQYPY-------------L R_norvegicus_ENSRNOP00000015775 ----PIF----PPHS-YIAASP---AYTGF-PLSPTKLSQYPY-------------M D_rerio_ENSDARP00000083736 ----PLF----PPHS-FI-ASP---AYAGF-PLSPTKLNQYPY-------------V G_aculeatus_ENSGACP00000017894 ----AQF----AHQA-YISASPASAVYTGY-PLSPTKVNQYPY-------------L T_rubripes_ENSTRUP00000010045 ----PLF----PPHS-YI-ASP---AYTSF-PLSPTKINQYPY-------------I O_latipes_ENSORLP00000015420 ----PAFPPPPPPHP-FM-ASP--AAYTGF-PLSPTKFSHHPQ-------------F T_rubripes_ENSTRUP00000004224 ----PPF---PPPHP-YM-ASP--AAYTGF-PLSPTKLGPHPQ-------------F P_pygmaeus_ENSPPYP00000020253 ----AQF----AHQT-YISASPASTVYTGY-PLSPAKVNQYPY-------------I G_aculeatus_ENSGACP00000021106 ----PLF----P--S-YI-ASP---AYASF-PLSPTKINQYPY-------------I G_gorilla_ENSGGOP00000003977 ----AQF----AHQT-YISASPASTVYTGY-PLSPAKVNQYPY-------------I G_aculeatus_ENSGACP00000000924 ----KLV-------------------------------------------------S G_aculeatus_ENSGACP00000000494 ----KLV-------------------------------------------------S A_gambiae_AGAP004833-PA --------------------------------------------------------I