>D_melanogaster_FBpp0075254 ------------------------------------------------------------ --MASVVADLPSYGPIA------------------------------------------- --FDQVDNNTNATQLFKNNI---------------------------------------- --------------------------------------------NKTRMNDLNRE----- ---ETRLKTFTD-WPL------DWLDKRQLAQ--------TGMY---FT----------H AGDKVKCF---------------------------------------------------- ----------FCGVEIGCWEQEDQPVP---EHQRWSPNCPLLRRRTTNNVPINAEALDRI LPPISYDICGANDSTLEMREHAYAEGVIPMSQLIQSIGMNAVNAAGSVTGTAAPQPRVTV ATHASTATQATGDVQPETCRPSAASGNYFPQ---YPEYAIETARLRTF-E---AWPR-NL KQKPHQLA-----EAGFFYT-GVGDRVRCF------------------------------ ------------SCGG------------------------GLMDWNDNDEPWEQHALWLS --QC---RFVKLM-KGQL-------------YIDTVAAK----------PVLAEEK--EE SSSIG------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----GVAVASTQASEEEQQT-SLSSEEA---VSGDVAPSVAPTAATRIFNKIVEATAVAT P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------STNSSGSTSIP------ ----------EEKLCKICYG---------------------------------------- ---AEYNTAFLPCGHVVACAKCASSVTKC------------------------------- ------------------------------------------------------------ -----------------------------PLCRKPFTD---VMRVYFS------------ ------------------------------------------------------------ ------------------- >A_aegypti_AAEL009074-PA ------------------------------------------------------------ -------------------------------------------------MAGVMMAQVLS TPRDFTDNKVKEDNAYGHT----------------------------------------- --------------------------------------------ATSVPISYHTE----- ---VARLESFRG-WMV------SFISKTELAR--------YGFY---YV----------G PNDMVKCY---------------------------------------------------- ----------FCRVEIGLWEPNDNVLS---EHLRWSPYCPLLRKRQTNNVPIDASFLDQL PEPSYDTCGIRIRENSVAENAYSSSDRSSSGSLTSPPSSLTSESSMASNGPVVQQLSAPV LPQQ-----------------------KLPE---YPNYAIEAKRLESY-E---DWPK-FM KQKPKELS-----DAGFFYT-GKSDRVKCF------------------------------ ------------SCGG------------------------GLKDWEAEDEPWEQHAMWYS --NC---EYLKLM-KGEA-------------YIAHCLAK----------KESSSEE---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -NGSDVGPSNSPQPSTSGVV---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SAATSSLQSSQSSSLS-VSAEEDN---TAMVGCS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------SDEDEPNRKLD------ ----------TSRTCKICYV---------------------------------------- ---NEYNTAFSPCGHVVACAKCASSVTKC------------------------------- ------------------------------------------------------------ -----------------------------PLCRKPFTN---VMRIYLM------------ ------------------------------------------------------------ ------------------- >A_gambiae_AGAP007294-PA ------------------------------------------------------------ ---------------------------------------------------MAHALSLPA PPIDLPDNKHKDDDL--------------------------------------------- --------------------------------------------ACMSPEYFHIE----- ---ENRLRSFTSRWPV------TFISPNVLAR--------YGFY---YV----------G TDDTVKCY---------------------------------------------------- ----------FCRVEIGLWEPQDDVIQ---EHLRWSPYCPLLKKRPTNNVPLNANYLDAV PEPSFDTCGISVRHNSLM------------------------------------------ ---------------------------RRPE---YPNYAIEADRLKSY-E---DWPT-SL KQKPQQLS-----DAGFFYT-GMSDRVKCF------------------------------ ------------SCGG------------------------GLKDWEQEDDPWQQHAIWYS --NC---HYLQLM-KGRE-------------FIQKCNEL----------KEAASAS---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---SAASTSSAMSSASSQPS-TDEGE---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------DDAGGDRRVPS------ ----------DGKICKICFV---------------------------------------- ---NEYNTAFMPCGHVVACAKCASSVSKC------------------------------- ------------------------------------------------------------ -----------------------------PLCQQPFIN---VLRLYLS------------ ------------------------------------------------------------ ------------------- >A_gambiae_AGAP007293-PA ------------------------------------------------------------ ----------------------------------------------MASAVVSCICREIA EYRVT------------------------------------------------------- --------------------------------------------HDTPEECLNYE----- ---VNRLRTFPL-WTV------PYIYPEELAR--------WGFF---YT----------G YRDCVRCY---------------------------------------------------- ----------FCRIELGGWDEHDVVIE---EHLKWSPHCRLMTKRPTNNVPIDPDFLDQL GEIVPDTTGTGSTSAWSAAATAAVAVAMESNRLNRQNELERQSQRTQNDTIPF------- ---------------------------YRQK---YPEYRIGGDRLATF-K---EWPK-SI PQTPTQMA-----DAGFFYT-GKSDVVACY------------------------------ ------------YCGG------------------------NLRDWLAEDDPWVEHVRNFS --EC---PYVKLV-KTPE-------------FIAECRGE----------KVTNSAL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------IASSERSG-HGN------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VSKDKEQDEVS------ ----------DEKCCKICYI---------------------------------------- ---RPFDTVFIPCGHVVACGKCAASTTKC------------------------------- ------------------------------------------------------------ -----------------------------PMCNESYTS---VQRIFLS------------ ------------------------------------------------------------ ------------------- >A_gambiae_AGAP007291-PA ------------------------------------------------------------ ----------------------------------------------MASTVVSCICREIA EYRVT------------------------------------------------------- --------------------------------------------HIVPEECLNYE----- ---INRLRTYDLLWTV------PYIYPEELAR--------WGFF---YT----------G HRDCVRCY---------------------------------------------------- ----------FCRIELGGWDEHDVVIE---EHLKWSPHCRLMTKRPTNNVPIDPDFLDQL GEIVPDTTGTGSTSAWSAAATAAAA---ESNRLNRQNELE----RTQNDTIPF------- ---------------------------YRQK---YPQYRIEGDRLATF-K---EWPK-SM PQTPERMA-----DAGFFYT-GKSDVVACF------------------------------ ------------YCGG------------------------NLRDWLAEDDPWVEHVRNFS --EC---PYVKLV-KTPE-------------FIAECRGE----------KVTNSAL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TAGPEHSG-HGN------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VSKDKEQDEVS------ ----------DEKCCKICFT---------------------------------------- ---RPFDTVFMPCGHVVACGRCAATTTKC------------------------------- ------------------------------------------------------------ -----------------------------PMCNEPYTS---VQRIYFS------------ ------------------------------------------------------------ ------------------- >A_gambiae_AGAP007292-PA ------------------------------------------------------------ ------------------------------------------------------------ --MESHDNTERQERT--------------------------------------------- --------------------------------------------GLCNELNYNQE----- ---INRLRTYFPLWTV------PYIYPEELAR--------WGFF---YT----------G YRDCVRCY---------------------------------------------------- ----------FCHIELGGWDEHDVVIE---EHLKWSPDCRLMTKRPTDNVPVDANFLDQL -----DTAGTGIPIQLGTAASRYNGPCNRYQPTSSHDNPEWHRQTVLNVSAPV------- ---------------------------YEPT---IPHYEIGDNRLASF-Q---EWPK-CM KQTPEQMA-----DAGFFYT-GKSDVVICF------------------------------ ------------CCGG------------------------QLRDWLPEYNPWVEHAKNFS --GC---PYLKLV-KTPG-------------FIAECQAK----------WYTNDVL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------IGRPEYPG-HD------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VTKRKEQHEVA------ ----------DENCCKICYT---------------------------------------- ---RPFDTVFIPCGHVVACGRCAASTLNC------------------------------- ------------------------------------------------------------ -----------------------------PVCNKWYTS---VQRILFT------------ ------------------------------------------------------------ ------------------- >G_aculeatus_ENSGACP00000003419 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------MTDDRGTAPRAPEAPRMRGE----- ---GERLRTFGR-WPA---DA--PVTSGELAG--------AGFF---YL----------G PGDEVQCF---------------------------------------------------- ----------CCGGVLKCWARGDRPAA---EHRRHFPDCGFALGRPAGN---VPLPAGSS DSVDGQLLSQLQRMTMDEQGTP-------------------------------------- ---------------------------GQAV---HPQLEAEDTRVTTF-H---NWPA-EA SVQPDVLA-----RAGFFYT-GHGDNVKCF------------------------------ ------------HCDG------------------------GLRNWEPGDDPWQEHAKWFP --RC---EFLIQE-RGQD-------------YISNVQDS----------HFHLDDT--VS GSQSSAGRDAGSRN---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------DV VGGLAASSA-----MLSPVV---QTVLQMGFEAALVESLVR------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------TRFLLTGQHYTSVSNL------------ ----VSDVLQ--AEQEDQRG-SRSAGNT-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------ERSEFPRTA--------------TD--PSPEELLRQLQ------ ----------EERTCKVCMD---------------------------------------- ---KLVSIVFIPCGHLVVCADCAASLRHC------------------------------- ------------------------------------------------------------ -----------------------------PICRAVIRG---SVRAFMS------------ ------------------------------------------------------------ ------------------- >T_guttata_ENSTGUP00000003825 ----------------------------------------ADTDG--------AREWAQE RERQGTFVGFPQGCPVS-VLALAQAGFVYTG---------------EGDKVKCFSCNTTI EGWVPGDSALERHKKLAPTCKFITESAFLKSDMDPVAQNYQNRTENG------------- ---------TSNSALP-CALDDPDVEADYLLRTRQVVDMSDS--LYPKNPAMCSE----- ---ETRLKSFHN-WPL---ND--RLTPQELAN--------AGFY---YT----------G VGDQVACF---------------------------------------------------- ----------CCGGKLKNWEPSDRAWS---EHKRHFPKCLFVQGRDIGN----------- ----------VSSESIPSELGISGLNNA-------------------------------- ---------------------------QHPR---NPSMTKYGKRLQTF-L---SW---IY PVAKERLA-----EAGFYSV-GNGDHVVCF------------------------------ ------------HCGG------------------------GLQEWKENEDPWDQHAKWFP --GC---RFVSNE-KGIE-------------FINNVHLK----------DGCRDST---V SVLLIN------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --HFVEIAKINIVLYENPWV---QSAIAMGFSLSEIRNTME------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------KRLQMTGESHTSVEDL------------ ----VADLS---AHTENTREEEPNEIPV---EQDEL------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------IHTEEKLRRLQ------ ----------EEKLCKICMA---------------------------------------- ---KDVSVVFIPCGHLVACKECAQLLNEC------------------------------- ------------------------------------------------------------ -----------------------------PLCRSDIMK---IQEIFMY------------ ------------------------------------------------------------ ------------------- >H_sapiens_ENSP00000360242 --------------------------MTFNSFEGSKTCVPADINK--------EEEFVEE FNRLKTFANFPSGSPVS-ASTLARAGFLYTG---------------EGDTVRCFSCHAAV DRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKV------------- ------ENYLGSRDHF-ALDRPSETHADYLLRTGQVVDISDT--IYPRNPAMYSE----- ---EARLKSFQN-WPD---YA--HLTPRELAS--------AGLY---YT----------G IGDQVQCF---------------------------------------------------- ----------CCGGKLKNWEPCDRAWS---EHRRHFPNCFFVLGRNL-N----------- ----------IRSESDAVSSDRNFPNST-------------------------------- ---------------------------NLPR---NPSMADYEARIFTF-G---TW---IY SVNKEQLA-----RAGFYAL-GEGDKVKCF------------------------------ ------------HCGG------------------------GLTDWKPSEDPWEQHAKWYP --GC---KYLLEQ-KGQE-------------YINNIHLT----------HS-LEEC--LV RTTEKT------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---PSLTRRIDDTIFQNPMV---QEAIRMGFSFKDIKKIME------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------EKIQISGSNYKSLEVL------------ ----VADLVN--AQKDSMQD-ESSQTSL---QKE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ISTEEQLRRLQ------ ----------EEKLCKICMD---------------------------------------- ---RNIAIVFVPCGHLVTCKQCAEAVDKC------------------------------- ------------------------------------------------------------ -----------------------------PMCYTVITF---KQKIFMS------------ ------------------------------------------------------------ ------------------- >M_musculus_ENSMUSP00000110746 --------------------------MTFNSFEGTRTFVLADTNK--------DEEFVEE FNRLKTFANFPSSSPVS-ASTLARAGFLYTG---------------EGDTVQCFSCHAAI DRWQYGDSAVGRHRRISPNCRFINGFYFENGAAQSTNPGIQNGQYKS------------- ------ENCVGNRNPF-APDRPPETHADYLLRTGQVVDISDT--IYPRNPAMCSE----- ---EARLKSFQN-WPD---YA--HLTPRELAS--------AGLY---YT----------G ADDQVQCF---------------------------------------------------- ----------CCGGKLKNWEPCDRAWS---EHRRHFPNCFFVLGRNV-N----------- ----------VRSESG-VSSDRNFPNST-------------------------------- ---------------------------NSPR---NPAMAEYEARIVTF-G---TW---TS SVNKEQLA-----RAGFYAL-GEGDKVKCF------------------------------ ------------HCGG------------------------GLTDWKPSEDPWEQHAKWYP --GC---KYLLDE-KGQE-------------YINNIHLT----------HS-LEES--LG RTAEKT------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---PSLTKKIDDTIFQNPMV---QEAIRMGFSFKDIKKTME------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------EKIQTSGSSYLSLEVL------------ ----IADLVS--AQKDNTED-ESSQTSL---QKD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ISTEEQLRRLQ------ ----------EEKLCKICMD---------------------------------------- ---RNIAIVFVPCGHLVTCKQCAEAVDKC------------------------------- ------------------------------------------------------------ -----------------------------PMCYTVITF---KQKIFMS------------ ------------------------------------------------------------ ------------------- >T_guttata_ENSTGUP00000007779 ------------------------------------------------------------ ------------------------------------------------------------ ----MGDAAPAQQPEPRAAR---------------------------------------- --------------------------------------------RRLFEASMRSV----- ---ARRLRTFQQ-WPR---TA--PVSARDLVE--------AGFF---YL----------G PGDEVQCF---------------------------------------------------- ----------CCGGILKDWRPGDCPMI---EHLHFFPSCKYLSGEDVGNQEMLSL-QEIF DTVDGQFLSVLQGIVSEETAQP-------------------------------------- ---------------------------NEPE---YPEMVTEEMRLSTF-E---NWPQ-NS SMHPEQLA-----RAGFFYT-GRGDVVRCF------------------------------ ------------YCDG------------------------GVRSWSFGDDPWREHAKWYP --EC---EFLLHS-RGRE-------------FVNSVQAT----------FSI-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GKDESQ------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LSTEEQLRRLR------ ----------EERTCKVCMD---------------------------------------- ---KDVSVVFVPCGHLVACEECALNLRLC------------------------------- ------------------------------------------------------------ -----------------------------PICRAGIQG---RVRAFMS------------ ------------------------------------------------------------ ------------------- >P_troglodytes_ENSPTRP00000038304 --------------------------MTFNSFEGSKTCVPADINK--------EEEFVEE FNRLKTFANFPSGSPVS-ASTLARAGFLYTG---------------EGDTVRCFSCHAAV DRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKV------------- ------ENYLGSRNHF-ALDRPSETHADYLLRTGQVVDISDT--IYPRNPAMYSE----- ---EARLKSFQN-WPD---YA--HLTPRELAS--------AGLY---YT----------G IGDQVQCF---------------------------------------------------- ----------CCGGKLKNWEPCDRAWS---EHRRHFPNCFFVLGRNL-N----------- ----------IRSESDAVSSDRNFPNST-------------------------------- ---------------------------NLPR---NPSMADYEARIFTF-G---TW---IY SVNKEQLA-----RAGFYAL-GEGDKVKCF------------------------------ ------------HCGG------------------------GLTDWKPSEDPWEQHAKWYP --GC---KYLLEQ-KGQE-------------YISNIHLT----------HS-LEEC--LV RTTEKT------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---PSLTRRIDDTIFQNPMV---QEAIRMGFSFKDIKKIME------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------EKIQISGSNYKRLEVL------------ ----VADLVN--AQIKGMQD-ESSQTS--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ISTEEQLRRLQ------ ----------EEKLCKICMD---------------------------------------- ---RNIAIVFVPCGHLVTCKQCAEAVDKC------------------------------- ------------------------------------------------------------ -----------------------------PMCYTVITF---KQKIFMS------------ ------------------------------------------------------------ ------------------- >G_gallus_ENSGALP00000009239 ------------------------------------------------------------ ------------------------------------------------------------ ----MADTAPVEGTHLRATC---------------------------------------- --------------------------------------------CHLFNYSMRDE----- ---ARRLRTFSQ-WPR---SS--PVSAWDLAK--------AGFF---FV----------G PGDQVQCF---------------------------------------------------- ----------SCGGILKDWEPGDCPIV---EHLKFFPFCKFIYHGAVWNQQ-VPL-QGVF DSVDGQILSLLQRIDSEETALP-------------------------------------- ---------------------------NQPE---YPEMVTEEMRLSTF-Q---NWPQ-YT EMRPEQLA-----RAGFFYT-GQGDVVRCF------------------------------ ------------YCDG------------------------GMRNWAFGDDPWREHAKWYP --RC---EFLLRS-MGRE-------------FVSSIFTD----------ECL-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SKEESP------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LSTEEQLRRLQ------ ----------EERMCKVCMD---------------------------------------- ---RDVSVVFVPCGHLVACGECALNLRLC------------------------------- ------------------------------------------------------------ -----------------------------PICRAVIQG---SVRTFMS------------ ------------------------------------------------------------ ------------------- >P_pygmaeus_ENSPPYP00000023167 --------------------------MTFNSFEGSKTCVPADINK--------EEEFVEE FNRLKTFANFPSGSPVS-ASTLARAGFLYTG---------------EGDTVRCFSCHAAV DRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKV------------- ------ENYLGSRNHF-ALDRPSETHADYLLRTGQVVDISDT--IYPRNPAMYSE----- ---EARLKSFQN-WPD---YA--HLTPRELAS--------AGLY---YT----------G IGDQVQCF---------------------------------------------------- ----------CCGGKLKNWEPCDRAWS---EHRRHFPNCFFVLGRNL-N----------- ----------IRSESDAVSSDRNFPNST-------------------------------- ---------------------------NLPR---NPSMADYEARIFTF-G---TW---IY SVNKEQLA-----RAGFYAL-GEGDKVKCF------------------------------ ------------HCGG------------------------GLTDWKPTEDPWEQHAKWYP --GC---KYLLEQ-KGQE-------------YINNIHLT----------HS-LEEC--LV RTTEKT------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---PSLTRRIDDTIFQNPMV---QEAIRMGFSFKDIKKIME------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------EKIQISGSNYKSLEVL------------ ----IADLVN--AQKDSTQD-ESSQTSL---QKE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ISTEEQLRRLQ------ ----------EEKLCKICMD---------------------------------------- ---RNIAIVFVPCGHLVTCKQCAEAVDKC------------------------------- ------------------------------------------------------------ -----------------------------PMCYTVITF---KQKIFMS------------ ------------------------------------------------------------ ------------------- >G_gallus_ENSGALP00000038337 --------------------------MTCNGPDSSESGATPATDG--------DQEWTQE HYRLGTFVEFPHDCPVS-ASALARAGFVYTG---------------EGDKVKCFSCHVTV EGWEPGDSAIDRHKNLSPDCRFITGSAFLENNVHPLVQSHQHRTENG------------- ---------SSNLALPSALEDLSDVEADYLLRTRQVVDMSDT--LYPKNPAMCSE----- ---EARLKSFHN-WPP---YG--LLTPKELAS--------AGLY---YT----------G VGDQVACF---------------------------------------------------- ----------CCGGKLKNWEPGDRAWS---EHKRHFPKCFFVLGRDVGN----------- ----------VSTDSICAELGRSCLNNE-------------------------------- ---------------------------QHPR---NPSMAEYERRIQTF-L---AW---IY PVNKEHLA-----EAGFYST-GNGDHVVCF------------------------------ ------------HCGG------------------------GLQEWKENEDPWDQHAKWFP --GC---KFLRDE-KGLE-------------FINNVHLR----------DGCRDST---I EAAE-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----VTILPKDDLLQNQLV---QNAIHMGFSLSEIRSIME------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------KKLHLSGESYTSVEDL------------ ----VADLIS--AQKENIKGEPPKESPL---EQD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LSIEEKLRRLQ------ ----------EEKLCKICMA---------------------------------------- ---KDISVVLIPCGHLVACKECAEAVNKC------------------------------- ------------------------------------------------------------ -----------------------------PLCCTNIIK---RQKIFMY------------ ------------------------------------------------------------ ------------------- >O_cuniculus_ENSOCUP00000008505 --------------------------MTFNSFEGSKTCVPADINK--------DEEFVEE FNRLKTFANFPSSSPVS-ASTLARAGFLYTG---------------EGDTVRCFSCHAAV DRWQYGDSAVGRHRKVSPNCRFINGFYFENSAAQSTNPGVQNGQYKG------------- ------ENYLGNRNHF-ALDRPSETHADYLLRTGQVVDISDT--IYPRNPAMCSE----- ---EARLKSFQN-WPD---YA--HLTPRELAS--------AGLY---YT----------G IDDQVQCF---------------------------------------------------- ----------CCGGKLKNWEPCDRAWS---EHRRHFPNCFFVLGRNV-N----------- ----------IRSESDVVSSDRNFPNST-------------------------------- ---------------------------NPPR---NPAMADYEARIISF-G---TW---IY SVNKEQLA-----RAGFYAL-GEGDKVKCF------------------------------ ------------HCGG------------------------GLTDWKPNEDPWEQHAKWYP --GC---KYLLEE-KGQE-------------YINNIHLT----------HS-LEES--LA RTAENT------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---PSQTKRIDDTIFQSPMV---QEAIRMGFSFREIKKIME------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------EKVQMCGSNYKSLEVL------------ ----VADLVN--AQKSSTQD-ESSQTSL---QKE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VSTEEQLRRLQ------ ----------EEKLCKICMD---------------------------------------- ---RNIAVVFIPCGHLVTCKQCAEAVDKC------------------------------- ------------------------------------------------------------ -----------------------------PMCYTVITF---KQKIFMS------------ ------------------------------------------------------------ ------------------- >R_norvegicus_ENSRNOP00000009358 --------------------------MTFNSFEGSRTVVPADTNK--------DEEFVEE FNRLKTFANFPSSSPVS-ASTLARAGFLYTG---------------EGDTVQCFSCHAAV DRWQYGDSAVGRHRRISPNCRFINGFYFENGATQSTSPGIQNGQYKS------------- ------ENCVGNRNHF-ALDRPSETHADYLLRTGQVVDISDT--IYPRNPAMCSE----- ---EARLKTFQN-WPD---YA--HLSPRELAS--------AGLY---YT----------G IDDQVQCF---------------------------------------------------- ----------CCGGKLKNWEPCDRAWS---EHRRHFPNCFFVLGRNV-N----------- ----------VRSESG-VSSDRNFPNST-------------------------------- ---------------------------NSPR---NPAMAEYDARIVTF-G---TW---LY SVNKEQLA-----RAGFYAL-GEGDKVKCF------------------------------ ------------HCGG------------------------GLTDWKPSEDPWEQHAKWYP --GC---KYLLDE-KGQE-------------YINNIHLT----------HS-LGES--VV RTAEKT------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---PSVTKKIDDTIFQNPMV---QEAIRMGFNFKDIKKTME------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------EKLQTSGSNYLSLEVL------------ ----IADLVS--AQKDNSQD-ESSQTSL---QKD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ISTEEQLRRLQ------ ----------EEKLCKICMD---------------------------------------- ---RNIAIVFVPCGHLVTCKQCAEAVDKC------------------------------- ------------------------------------------------------------ -----------------------------PMCCTVITF---KQFLCLNPAPQ-------- ------------------------------------------------------------ ------------------- >D_melanogaster_FBpp0086432 ---------------------------------------------------MTELGMELE SVRLATFGEWPLNAPVS-AEDLVANGFFATG---------------NWLEAECHFCHVRI DRWEYGDQVAERHRRSSPICSMVLAPNHCGNVPRSQESDNEGNSVVD------------- ------------------------------------------SPESCSCPDLLLE----- ---ANRLVTFKD-WPN---P---NITPQALAK--------AGFY---YL----------N RLDHVKCV---------------------------------------------------- ----------WCNGVIAKWEKNDNAFE---EHKRFFPQCPRVQMGPLIEFATGKNLDELG IQPT-------------------------------------------------------- ---------------------------TLPL---RPKYACVDARLRTF-T---DWPI-SN IQPASALA-----QAGLYYQ-KIGDQVRCF------------------------------ ------------HCNI------------------------GLRSWQKEDEPWFEHAKWSP --KC---QFVLLA-KGPA-------------YVSEVLAT----------TAANASS---- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------Q PATAPAPTLQADVLMDEAPA---KEALALGIDGGVVRNAIQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------RKLLSSGCAFSTLDEL------------ ----LHDIFD--DAGAGAAL-EVREPPE---PSAPFIEPCQATTSKAASVPIPVADSIPA KPQAAEAVANISKITD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------EIQKMSVATPNGNLSLEEENRQLK------ ----------DARLCKVCLD---------------------------------------- ---EEVGVVFLPCGHLATCNQCAPSVANC------------------------------- ------------------------------------------------------------ -----------------------------PMCRADIKG---FVRTFLS------------ ------------------------------------------------------------ ------------------- >T_rubripes_ENSTRUP00000011958 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------MLEEPRMRRE----- ---GDRIRTFQE-WPA---DA--AVAPADLAR--------AGFF---FL----------G PGDAVQCF---------------------------------------------------- ----------CCGGILRCWMQGDTPGD---EHRRHFPTCCFVLGKAVGN---IPLQAGFS DSVDGQLLSQLQRMTMDDQGTV-------------------------------------- ---------------------------GQAV---YPEMEAEDSRLTTF-H---NWPT-EA SVQPDVLA-----RAGFFYT-GHGDNVKCY------------------------------ ------------YCDG------------------------GLRNWEPGDDPWQEHAKWFP --RC---EFLIQT-RGQE-------------YISNIQDT----------HFHLGDT--VG GSQSSSSRDIGPRNASHLP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------DM V------RA-----MLSPVV---QTVLQMGFEAGLVESLVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------TKYLLTGRQYTSVSDL------------ ----VSDVLQ--AEQEDRAR-APQSTVP---S---------------------------R SR---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------ASA HFSP-----------------PPTV--------------NE--PSPEELLRQLQ------ ----------EERTCKVCMD---------------------------------------- ---KLVSIVFIPCGHLVVCSDCAASLRHC------------------------------- ------------------------------------------------------------ -----------------------------PICRAVIRG---SVRAFMS------------ ------------------------------------------------------------ ------------------- >X_tropicalis_ENSXETP00000029187 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VPPNMRSE----- ---AERQRSFRA-WPH---TC-RTVSPAELAR--------SGFY---YL----------G PGDRVQCF---------------------------------------------------- ----------SCGGVLRSWEPGDRPDT---EHRKFFPSCPFLQVRRGPP--------GGT DSVDGQILGQLSGEEPDRT----------------------------------------- ---------------------------WEPV---CPQMAGEGDRLGSF-S---TWPR-YA NGDPQQLA-----GAGFFYT-GHRDHVKCF------------------------------ ------------HCDG------------------------GLRNWEQGDDPWTEHAKWFP --MC---DFLLQV-KGEA-------------FIRSVQES----------FFSSPET--SP ESVGSY------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EG SPVSSPGSPPVCPFLSTSVA---QGALQVGFKRNRVSSLMI------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------NRFILTGSCYGSVSEL------------ ----VTDLIR--AEEIHGTE-SVSVPRA---PTQRERPEPPKEPAPP------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LSTEEQLRQLK------ ----------EERMCKVCMD---------------------------------------- ---NDVSMVFVPCGHLVVCTECAPNLRHC------------------------------- ------------------------------------------------------------ -----------------------------PICRAAIRG---SVRAFMS------------ ------------------------------------------------------------ ------------------- >C_familiaris_ENSCAFP00000034255 --------------------------MTFNSFEGAKTCVPAGINK--------DEEFVEE FNRLKTFANFPSSSPVS-ASTLARAGFLYTG---------------EGDTVRCFSCHASI DRWQYGDSAVGRHRKVSPNCRFINGFYFENTAAQPTNPGIQNGQYNA------------- ------ENYLRNRDHF-VLDRPSETHADYLLRTGQVVDISDT--TYPENPAMYSE----- ---EARLNSFQN-WPD---YV--HLTPRELAS--------AGFY---YT----------G IDDQVQCF---------------------------------------------------- ----------CCGGKLKNWEPCDNAWS---EHRRHFPNCFFVLGRNV-N----------- ----------IRSESDVASTDRNVPNST-------------------------------- ---------------------------SIPE---NPAMADYEARIVTF-R---MW---MC SINKEQLA-----RAGFYSL-GDGDKVKCF------------------------------ ------------HCGG------------------------GLTDWKPSEDPWEQHAKWFP --GC---KYLLEE-KGQE-------------YINNIHLT----------HSVVSHI--LL RTAERT------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---RSLTERIEDAIFQNPML---QEAIRMGFSFKDIKKIME------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------EKIQTSGSNYVSLEAL------------ ----VSDLVS--AQKDHTQD-ESSQTSL---QKE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ISAEEQLRLLQ------ ----------EEKLCKICMD---------------------------------------- ---RNIAVVFIPCGHLVTCKQCAEAVDKC------------------------------- ------------------------------------------------------------ -----------------------------PMCYTVITF---KQKIFMS------------ ------------------------------------------------------------ ------------------- >O_anatinus_ENSOANP00000006435 --------------------------MTCNSPEELRTSNPSEVNK--------DEEFAEE HNRLRTFANFPSTSPVS-SSTLARAGFLYTG---------------EEDVVRCFSCHVAV DRWQYGDSAIGRHRKISPNCRFVNGCHFKNCALPLANASLQNGELGQ------------- -----VEECPGNPSHH-ALERSSETHSDYLLRTRQVVDLSDT--VFPKNPAMCSE----- ---EARLETFQN-WPE---YT--LLSPGQLAR--------AGLY---YS----------G IDDQVECF---------------------------------------------------- ----------CCGGKLKNWEPCDRPWS---EHKRHFPKCLFVLGRDVGN----------- ----------IEIESDSIASQRSYSNST-------------------------------- ---------------------------HFPR---NPAMAEFEARIHTF-E---TW---TY SIDKELLA-----RAGFYTL-GEQDKVICF------------------------------ ------------HCGG------------------------GLTDWKPNEDPWEQHAKWFP --GC---KYLVEQ-KGQE-------------FINNVHLT----------QS-LEDS--VL EADETP------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---PSLTKAITIIVFQNLVVGQLAEARAMLYKFYHAHTSIC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------KVVTIRKLVYSPLEML------------ ----TKSVSK--GREANSNP-KSTHYFLFFPSVE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ISPEEELRRLQ------ ----------EEKLCKICMD---------------------------------------- ---KNIAVVFLPCGHLVACKECGEAMGKC------------------------------- ------------------------------------------------------------ -----------------------------PVCCTLINY---RQKIFMS------------ ------------------------------------------------------------ ------------------- >E_caballus_ENSECAP00000017630 --------------------------MTFNSFEGSKTCVPADIDK--------DEEFVEE FNRLKTFANFPSSSPVS-ASTLARAGFLYTG---------------EGDTVQCFSCHAAV DRWQYGDSAVGRHRKVSPNCRFINGFYFENNAAQPTNPGVQNGQYKV------------- ------ENYLGNRNHF-VLGRPSETHAEYLLRTGQVVDISDT--IYPRNPAMCSE----- ---EARLKSFQN-WPD---YA--HLTPGELAS--------AGLY---YT----------G IDDQVQCF---------------------------------------------------- ----------CCGGKLKNWEPCDRAWS---EHRRHFPNCFFVLGRNV-N----------- ----------IRSESDVVSSDRNFSNST-------------------------------- ---------------------------NLPR---NPAMADYEARIITF-G---TW---IY SVNKEQLA-----RAGFYAL-GEGDKVQCF------------------------------ ------------HCGG------------------------GLTDWKPSEDPWEQHAKWYP --GC---KYLLEE-KGQE-------------YISNIHLT----------CS-LEES--LV RTAEKT------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------TERIDDTIFRNPMV---QEAIRMGFSFRDIKKIME------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------EKIHTSGSNYRSLEIL------------ ----VADLVN--AQKDNTQD-ESSQTSL---QQE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ISAEEQLRLLQ------ ----------EEKLCKICMD---------------------------------------- ---RNIAVVFIPCGHLVTCKQCAEAVDKC------------------------------- ------------------------------------------------------------ -----------------------------PMCNTVITF---KQKIFMS------------ ------------------------------------------------------------ ------------------- >B_taurus_ENSBTAP00000053449 --------------------------MTFNSFEGSKTCVPADIDK--------DEEFVEE FNRLKTFANFPSSSPVS-ASTLARAGFLYTG---------------EGDTVRCFSCHAAV DRWQYGDSAIGRHRRVSPNCRFINGFYFENNAAQPTYSGVQNGQYKA------------- ------ENYLGNRNHF-VLERPSETHAHYLLRTGQVVDLSDT--VYPRNPVMCSE----- ---EARLKSFHN-WPD---YA--HLTPRELAR--------AGLY---YT----------G IDDQVQCF---------------------------------------------------- ----------CCGGKLKNWEPCDRAWS---EHRRHFPNCFFVLGRNI-N----------- ----------MQSESSVVSSDRNFPNST-------------------------------- ---------------------------NAPI---NPAMADYEARIITF-G---TW---MY SVNKEQLA-----RAGFYAL-GEGDKVQCF------------------------------ ------------HCGG------------------------GLNDWKPSEDPWEQHAKWFP --GC---KYLLEE-KGEE-------------YVNNIHLT----------HS-IEES--LV SHILNT------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---PSPIFISDDTIFQNPMV---QEAIRMGFSFKDIKKTME------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------GKIQTSGSNYKSLEVL------------ ----VADLVN--AQKDNTQD-ESSQTSL---QKD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ISTEEQLRLLQ------ ----------EEKLCKICMD---------------------------------------- ---RNIAVVFIPCGHLVTCKQCAEAVDKC------------------------------- ------------------------------------------------------------ -----------------------------PMCYTAITL---RQKIFMS------------ ------------------------------------------------------------ ------------------- >M_domestica_ENSMODP00000021022 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------V----------G PQDRVQCF---------------------------------------------------- ----------CCGGMLDNWMAGDSPIL---EHQRFFPKCQFALSKHTGN---IPA-QDTS DSVDGQILSQLQRISEEGEGEGNEDTVT-------------------------------- ---------------------------TRPV---YPDMGVEQIRLASF-H---NWPS-AA VVCPQQLA-----RAGFFYT-GQHDHVKCY------------------------------ ------------YCDG------------------------GLRNWDRGDDPWREHAKWFP --RC---EFLLQS-RGRA-------------YVNSIQDS----------S-SLLDS--WG HGEDPQ------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EV APTSTPASVPM------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----ASESTP--PRRESQPE-QITETDP---LSVFLYLCS--LTLST------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GP--LSTEQQLQQLK------ ----------EERTCKVCMY---------------------------------------- ---QVVSIVFVPCGHL-VCSECAPNLQQC------------------------------- ------------------------------------------------------------ -----------------------------PICRAAIHG---SIRTFLS------------ ------------------------------------------------------------ ------------------- >A_aegypti_AAEL006633-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------ELKRE----- ---EHRLATYVN-WPI---S---HISPSSLAK--------AGFY---YT----------Y NADQVKCA---------------------------------------------------- ----------WCEGVIGQWELGDDPFV---EHQKFFPNCAKVISNGISSNPILDPTIGIQ PV---------------------------------------------------------- ---------------------------KTPY---APQFSSLDSRIRSF-E---NWTT-GH IQDPERLA-----QAGFYYL-GRADEVHCF------------------------------ ------------YCDG------------------------GLRFWLADDDPWFEHARCFP --KC---QFVQLV-KGQL-------------FIENVQSQ----------IKSTSSN---- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------QQQ QMQASGPTMSLDEALATEPV---QLALSMGLNAGRIRAVTK------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------RQLDSTGHPYADSQAL------------ ----IEAVLD--GQIQDEEL-EPSTSSR---MDRRIESEVSRLLWTAISSTAGPNLSSFS STFSTPSPSFDSAPTSDGDVIVSSDPLSSPSTSSIANNASTSS----------------- ------------------------------------------------------------ --------------------------------------------------------AVKC NNVPESLAQMAAAARPTETAEVDKT------------------LRLEEENKRLK------ ----------DARECKICMA---------------------------------------- ---DEVGVVFCPCGHLVSCVQCAPAVTNC------------------------------- ------------------------------------------------------------ -----------------------------PVCRAVIKG---RVRTFLS------------ ------------------------------------------------------------ ------------------- >R_norvegicus_ENSRNOP00000014560 ------------------------------IMEN-STVLSNWTKEN--KEKM-KYDFSCE LYRMSTYSAFPRGVPVS-ERSLARAGFYYTG---------------VNDKVKCFCCGLML DNWKQGDSPTEKHRQFYPSCSFVQTLLS-GGLQSAAKNT-SPAKSRF------------- --AHS-LP--LEQ-----GGIHSS-LPSNPLNSRAVEDFS-LR-MNPCSYAMSTE----- ---EARFLSYSM-WPL---S---FLSPAELAK--------AGFY---YT----------G PGDRVACF---------------------------------------------------- ----------ACGGKLSNWEPNDDPLS---EHRRHFPHCPFLENTS-ET----------- ----------QR------------------------------------------------ ---------------------------FSVS---NLSMQTHSARMRTF-L---YWPS-SV LVQPEQLA-----SAGFYYV-DHNDDVKCF------------------------------ ------------CCDG------------------------GLRCWEPGDDPWIEHAKWFP --RC---EFLIRM-KGQE-------------FVDEIQAR----------YPHLLEQ--LL STSDTSEEENADPPER-------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------VV HLGPGE-NWEDAVMMNTPVV---KAALDMGFSRSLVRQTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------RQILATGENYRTVSDI------------ ----VSALLN--AEDERREE-EKERQSE---ETAS--GDLSLIRKNR---MALFQQLTC- VIPILDDLLEASVLTKEEHDIIRQKTQIPLQARELIDTILVKG----------------- ------------------------------------------------------------ --------------------------------------------------------NAAA SVFKNSLKEVDSTLYEHLFVEKTMK-----YIPTEDV--SG--LSLEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---REVSIVFIPCGHLVVCRECAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRGTIKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >M_domestica_ENSMODP00000018715 --------------------------MTFKSFEDSKTCVPPDINK--------DEDFVEE FNRLKTFANFPSSSPIS-ASTLARAGFLYTG---------------EGDTVKCFSCHAAV DRWQYGDSAVGRHRKVSPNCRFINGFYFEKNATRFPNPIIQNCQYRV------------- ------ENCSRNRNHF-ALERPSETHGEYLLRTGQVIDMSDT--IYPRNPSMCSE----- ---EARLRSFQN-WPD---YA--HLTPQELAS--------AGLY---YM----------G FEDQVQCF---------------------------------------------------- ----------CCGGKLKNWEPCDRAMS---EHKRHFPKCFFVLGRDVGN----------- ----------TRIETD-VSCDRSCPNPT-------------------------------- ---------------------------HLPR---NPAMADYEARLITF-A---TW---IY SVNKEQLA-----KAGFYAL-GDHDKVLCF------------------------------ ------------HCGG------------------------GLTDWKPNEDPWEQHAKWYP --GC---KYLLEE-KGQE-------------YVSSIHLV----------HP-FNSS--MV KSRKMA------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---SSVTQEIDDSVLQNPLV---QDAIRMGFNFLEIKKIMR------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------EKIQSSGNNYTSLELL------------ ----VADLVS--AQKESSQDGESSPTLS---EKE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ISTEEQLRRLQ------ ----------EEKLCKICMD---------------------------------------- ---ENIAVVFIPCGHLVSCQLCAEAIDKC------------------------------- ------------------------------------------------------------ -----------------------------PMCYTVITF---KQKIFIRKPSPN------- ------------------------------------------------------------ ------------------- >C_familiaris_ENSCAFP00000022277 --------MHKTTSQRLVPG-SY--QRIKRTMED-STILRNQTIGN--KQKI-KYDFSCE LYRMSTYSTFPAGVPVS-ERSLARAGFYYTG---------------VNDKVKCFCCGLML DNWKPGDNPVEKHKQLYPSCSFIHSLVSLTSRDSTSKNI-SAMRNSF------------- --THS-ISPTLEH-GS-FSGSHSN-LAANPVSSRAGEDFSPLS-TNPYSYAMSTE----- ---EARFLTYHM-WPL---T---FLSPSDLAR--------AGFY---YI----------G PGDKVACF---------------------------------------------------- ----------ACGGTLSNWEPKDDAMS---EHRRHFPNCPFLENSL-ET----------- ----------LR------------------------------------------------ ---------------------------FSIS---NLSMQTHAARLRTF-V---YWPS-SV PVRPEQLA-----SAGFYYV-GRNDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWVEHAKWFP --RC---EFLIRM-KGQE-------------FVDEIQAR----------YPHLLEQ--LL STSDTPGDENADPPNS-------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------FV HFGPGENHSEDTVMMNTPVV---KAALEMGFSRILVRQTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SKILSTGENYRTVNEI------------ ----VLALLN--AEDETREE-EKERQTE---EMAS--DDLSLIRRNR---MALFQQLTC- VLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTVLVKG----------------- ------------------------------------------------------------ --------------------------------------------------------NSAA NIFKSCLKEIDSTLYKNLFVDKNMK-----YIPTEDV--SG--LSLEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---KEVSIVFIPCGHLVVCQECAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRGIIKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >P_pygmaeus_ENSPPYP00000004357 --------MHKTASQRLFPGPSY--QN-KSIMED-STILSDWTNSN--KQKM-KYDFSCE LYRMSTYSTFPAGVPVS-ERSLARAGFYYTG---------------VNDKVKCFCCGLML DNWKLGDSPIQKHKQLYPSCSFIQNLVS-ASLGSTSKNT-SPMRNSF------------- --AHS-LSPTLEHSSL-FSGSYSS-LSPNPLNSRAVEDFSSSR-TNPYSYAMSTE----- ---EARFLTYHM-WPL---T---FLSPSELAR--------AGFY---YI----------G PGDRVACF---------------------------------------------------- ----------ACGGKLSNWEPKDDAMS---EHRRHFPNCPFLENSL-ET----------- ----------LR------------------------------------------------ ---------------------------FSIS---NLSMQTHAARMRTF-M---YWPS-SV PVQPEQLA-----SAGFYYV-GRNDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWVEHAKWFP --RC---EFLIRM-KGQE-------------FVDEIQGR----------YPHLLEQ--LL STSDTTGEENADPP---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------II HFGPGESSSEDAVMMNTPVV---KSALEMGFNRDLVKQTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SKILTTGENYKTVNDI------------ ----VSALLN--AEDEKREE-EKEKQAE---EMAS--DDLSLIRKNR---MALFQQLTC- VLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKG----------------- ------------------------------------------------------------ --------------------------------------------------------NAAA NIFKNCLKEIDSTLYKNLFVDKNMK-----YIPTEDV--SG--LSLEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---KEVSIVFIPCGHLVVCQECAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRGIIKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >O_anatinus_ENSOANP00000016616 -----VHKTTSRGETRPVSPATPTEYFVMNVVAN-SMFLSNLMNGNS-GYEL-KYDFSCE LFRMSTYSTFPTNVPVS-ERSLARAGFYYTG---------------ASDKVKCFSCGLML DNWKPGDSAIEKHKQLYPSCSFIQNLLQTHNPGASSYSAFCPPPLGS---------LSP- --TAT-ISPSLEPSGY-FSGSFSS-FPLDPVTSRAIEDLSQPR-PHVDNSAMSSE----- ---EARICTFQS-WPL---T---FLSPSALAK--------AGFY---YT----------G PGDRVACF---------------------------------------------------- ----------TCGGKLSNWEPKDDAMS---EHRRHFPGCPFLERQTRDA----------- ----------SR------------------------------------------------ ---------------------------FNVS---NASMQTHAARVKTF-L---NWPA-RI PVQPEQLA-----SAGFYYV-GRNDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWIEHAKWFP --RC---EYMIRM-KGQE-------------FVNQIQAR----------YPHLLEQ--LL STSDTPVDESADPP---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------II HFGPGENPAEDAIMMSNPVV---KAALEMGFSRRLVKQTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SKILTTGENYKTVNDL------------ ----VSDLLN--AEDETREE-EKERQNE---EMAS--DDLSLIRKNR---MALFQHLTC- VLPILDSLLSAGVISEQERDVIKQKTQTSLQARELIDTVLVKG----------------- ------------------------------------------------------------ --------------------------------------------------------NAAA NIFKNCLKEDDCILYKNLFVEKNMK-----YIPTEDV--SG--LPMEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---KEVSIVFIPCGHLVVCKECAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRGTIKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >M_musculus_ENSMUSP00000091422 --------MDKTVSQRLGQGTLH--QKLKRIMEK-STILSNWTKES--EEKM-KFDFSCE LYRMSTYSAFPRGVPVS-ERSLARAGFYYTG---------------VNDKVKCFCCGLML DNWKQGDSPVEKHRQFYPSCSFVQTLLS-ASLQSPSKNM-SPVKSRF------------- --AHS-SP--LER-----GGIHSN-LCSSPLNSRAVEDFS-SR-MDPCSYAMSTE----- ---EARFLTYSM-WPL---S---FLSPAELAR--------AGFY---YI----------G PGDRVACF---------------------------------------------------- ----------ACGGKLSNWEPKDDAMS---EHRRHFPHCPFLENTS-ET----------- ----------QR------------------------------------------------ ---------------------------FSIS---NLSMQTHSARLRTF-L---YWPP-SV PVQPEQLA-----SAGFYYV-DRNDDVKCF------------------------------ ------------CCDG------------------------GLRCWEPGDDPWIEHAKWFP --RC---EFLIRM-KGQE-------------FVDEIQAR----------YPHLLEQ--LL STSDTPGEENADPTET-------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------VV HFGPGE-SSEDVVMMSTPVV---KAALEMGFSRSLVRQTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------RQILATGENYRTVNDI------------ ----VSVLLN--AEDERREE-EKERQTE---EMAS--GDLSLIRKNR---MALFQQLTH- VLPILDNLLEASVITKQEHDIIRQKTQIPLQARELIDTVLVKG----------------- ------------------------------------------------------------ --------------------------------------------------------NAAA NIFKNSLKEIDSTLYENLFVEKNMK-----YIPTEDV--SG--LSLEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---REVSIVFIPCGHLVVCQECAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRGTIKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >H_sapiens_ENSP00000227758 --------MHKTASQRLFPGPSY--QNIKSIMED-STILSDWTNSN--KQKM-KYDFSCE LYRMSTYSTFPAGVPVS-ERSLARAGFYYTG---------------VNDKVKCFCCGLML DNWKLGDSPIQKHKQLYPSCSFIQNLVS-ASLGSTSKNT-SPMRNSF------------- --AHS-LSPTLEHSSL-FSGSYSS-LSPNPLNSRAVEDISSSR-TNPYSYAMSTE----- ---EARFLTYHM-WPL---T---FLSPSELAR--------AGFY---YI----------G PGDRVACF---------------------------------------------------- ----------ACGGKLSNWEPKDDAMS---EHRRHFPNCPFLENSL-ET----------- ----------LR------------------------------------------------ ---------------------------FSIS---NLSMQTHAARMRTF-M---YWPS-SV PVQPEQLA-----SAGFYYV-GRNDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWVEHAKWFP --RC---EFLIRM-KGQE-------------FVDEIQGR----------YPHLLEQ--LL STSDTTGEENADPP---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------II HFGPGESSSEDAVMMNTPVV---KSALEMGFNRDLVKQTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SKILTTGENYKTVNDI------------ ----VSALLN--AEDEKREE-EKEKQAE---EMAS--DDLSLIRKNR---MALFQQLTC- VLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKG----------------- ------------------------------------------------------------ --------------------------------------------------------NAAA NIFKNCLKEIDSTLYKNLFVDKNMK-----YIPTEDV--SG--LSLEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---KEVSVVFIPCGHLVVCQECAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRGIIKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >T_nigroviridis_ENSTNIP00000012883 --L----PALFEGLLPFILLCFDTKMETLVQLKN-NPFLMGLCRNCP-PPDL-QYDNSSE LYRISTFARFP-SSGVT-ERSLARAGWFYTG---------------VGDRVQCFKCNVTA EGWQAGDCPTEKHRQLSPSCTFIQSLPSTSNLLSSSHSAFSPLRIAPAIPLSG---AGPA VPNPS-ANPGEEPVGY-LNMGFSAPPPSSPLGSRGVEDMSHQR-PTCHNPNMRRE----- ---QDRLDSFHS-WTL---T---IITPAELAK--------AGFY---YL----------S QGDRVACF---------------------------------------------------- ----------SCGGQLNNWEPGDRAMS---EHQRHYPNCRFVRGDRADNISLAGA-VPGG LTSQLSGGVPTL------------------------------------------------ ---------------------------SNVS---NPAMQQSEERLLTF-V---NWPS-RI PVRPDQLA-----RAGFYYV-GRNDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWVEHAKWFP --RC---EYLLQE-KGQD-------------FVHQIQAR----------FPRLFEQQKLL TNGDTSSREFVDPP---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------VV HLGPGEERSEDAVMMNTPVI---KSALEMGFERSLVKQTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SKILTSGENYRTVQEL------------ ----VSDLLS--AEDQKREE-EREMLAE---AMAS--DGFTFVKRHQ---AALIQRLKS- VEPVLEHLREQNVLSHEEYSGLKAQTSAQQQTARLIELILTKG----------------- ------------------------------------------------------------ --------------------------------------------------------NAAA EVFRNWIQKNDVHLLRDLMAQSSEA-----SSPSQDL--SD--LPMEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---KEVNIVFIPCGHLVVCKECAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRGLVKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >P_troglodytes_ENSPTRP00000007251 --------MHKTASQRLFPGPSY--QNIKSIMED-STILSDWTNSN--KQKM-KYDFSCE LYRMSTYSTFPAGVPVS-ERSLARAGFYYTG---------------VNDKVKCFCCGLML DNWKLGDSPIQKHKQLYPSCSFIQNLVS-ASLGSTSKNT-SPMRNSF------------- --AHS-LSPTLEHSSL-FSGSYSS-LSPNPLNSRAVEDISSSR-TNPYSYAMSTE----- ---EARFLTYHM-WPL---T---FLSPSELAR--------AGFY---YI----------G PGDRVACF---------------------------------------------------- ----------ACGGKLSNWEPKDDAMS---EHRRHFPNCPFLENSL-ET----------- ----------LR------------------------------------------------ ---------------------------FSIS---NLSMQTHAARMRTF-M---YWPS-SV PVQPEQLA-----SAGFYYV-GRNDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWVEHAKWFP --RC---EFLIRM-KGQE-------------FVDEIQGR----------YPHLLEQ--LL STSDTTGEENADPP---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------II HFGPGESSSEDAVMMNTPVV---KSALEMGFNRDLVKQTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SKILTTGENYKTVNDI------------ ----VSALLN--AEDEKREE-EKEKQAE---EMAS--DDLSLIRKNR---MALFQQLTC- VLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKG----------------- ------------------------------------------------------------ --------------------------------------------------------NSAA NIFKNCLKEIDSTLYKNLFVDKNMK-----YIPTEDV--SG--LSLEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---KEVSVVFIPCGHLVVCQECAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRGIIKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >E_caballus_ENSECAP00000000598 -------------------------------MED-STILSSWTVGN--KQKM-KYDFSCE LYRMSTYSTFPTGVPVS-ERSLARAGFYYTG---------------VNDKVKCFCCGLML DNWKQGDNPIEKHKQLYPSCSFIQNLVSVTSLESTSKNTSSPMRNSF------------- --THS-LSPTLEHSGS-FSGSYSN-LSPNLVNSRAVEDFSPLR-TNPYSYAMSTE----- ---EARFLTYHM-WPL---T---FLSPSELAR--------AGFY---YI----------G PGDRVACF---------------------------------------------------- ----------ACGGTLSNWEPKDDAMS---EHRRHFPNCPFLENSL-ET----------- ----------LR------------------------------------------------ ---------------------------FSIS---NLSMQTHAARLRTF-M---YWPP-RV PVQPEQLA-----SAGFYYV-GRNDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWVEHAKWFP --RC---EFLISM-KGQE-------------FVDEIQAR----------YPHLLEQ--LL STSDTPGDENADPP---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------IV HFGPGESSSEDAVMMNTPVI---KAALEMGFSRSLVKQTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SKILTTGENYKTVNDI------------ ----VSALLN--AEDEKREE-EKERQTE---EMAS--DDLSLIRRNR---MALFQQLTC- VLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTVLVKG----------------- ------------------------------------------------------------ --------------------------------------------------------NAAA NIFKNCLKEIDSTLYENLFVEKNMK-----YIPTEDV--SG--LSLEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---KEVSIVFIPCGHLVVCQECAPALRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRGIIKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >G_gallus_ENSGALP00000035646 ----------------------------MNIMDS-SPLLASVMKQNAHCGEL-KYDLSCE LYRMSTFSTFPVNVPVS-ERRLARAGFYYTG---------------VQDKVKCFSCGLVL DNWQPGDNAMEKHKQVYPSCSFVQNMLSLNNLGLSTHSAFSPLVASN---------LSPS LRSMT-LSPSFEQVGY-FSGSFSS-FPQDPVTTRAAEDLSHLR-SKLHNPSMSTE----- ---EARLRTFHA-WPL---M---FLSPAELAK--------AGLY---YL----------G TADKVACF---------------------------------------------------- ----------TCGGQLSNWEPKDNAMS---EHRRHFPNCPFVENLMRDQ----------- ----------PS------------------------------------------------ ---------------------------FNVS---NVTMQTHEARVKTF-I---NWPT-RI PVQPEQLA-----DAGFYYV-GRNDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWIEHAKWFP --RC---EYLLRV-KGGE-------------FVSQVQAR----------FPHLLEQ--LL STSDTPVDENMD-P---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------II HFEPGESPSEDAIMMNTPVV---KAALEMGFSRRLIKQTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SKILATEENYKTVNDL------------ ----VSDLLT--AEDEKREE-EKERQFE---EVAS--DDLSLIRKNR---MALFQRLTS- VLPILGSLLSAKVITELEHDVIKQKTQTPLQARELIDTVLVKG----------------- ------------------------------------------------------------ --------------------------------------------------------NAAA SIFRNCLKDCDPVLYKDLFVEKSMK-----YVPTEDV--SG--LPMEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---KEVSIVFIPCGHLVVCKECAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRGTIKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >M_mulatta_ENSMMUP00000004536 --------MHKTASQRLFPGPSY--QNIKSIMED-STILSDWTNSN--KQKM-KYDFSCE LYRMSTYSTFPTGVPVS-ERSLARAGFYYTG---------------VNDKVKCFCCGLML DNWKLGDSPIEKHKQLYPSCSFIQNLVS-ATLGSTSKNT-SPMRNSF------------- --AHS-LSPTLEHSSL-FSGSYSS-LSPNPLNSRAVEDLSPSR-TNPYSYAMSTE----- ---EARFLTYHM-WPL---T---FLSPSELAR--------AGFY---YI----------G PGDRVACF---------------------------------------------------- ----------ACGGKLSNWEPKDDAMS---EHRRHFPNCPFLENSL-ET----------- ----------LR------------------------------------------------ ---------------------------FSIS---NLSMQTHAARMRTF-M---YWPS-SV PVQPEQLA-----SAGFYYV-GRNDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWVEHAKWFP --RC---EFLIRM-KGQE-------------FVDEIQGR----------YPHLLEQ--LL STSDTTGDENADPP---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------II HFGPGESSSEDAVMMNTPVV---KSALEMGFSRDLVKQTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SKILTTGENYKTVNDI------------ ----VSALLN--AEDEKREE-EKERQAE---EMAS--DDLSLIRKNR---MALFQQLTC- VLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTVLVKG----------------- ------------------------------------------------------------ --------------------------------------------------------NAAA NIFKNCLKEIDSTLYKNLFVDKNMK-----YIPTEDV--SG--LSLEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---KEVSIVFIPCGHLVVCQECAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRGIIKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >D_rerio_ENSDARP00000013586 ---------------------------FPPQRNLVTTNMAHSTHNGELESDNVAADWSVM KNRVNSFQRFPYSEDIS-AQRLARAGFYFTG---------------EGDRVQCFSCSATV QNWNRGDTPLERHQLASPDCRFLSCAHGMRNSNSIQSP-----DYDE------------- ----------------------EAENREFLLRTGEVVDES----MYPVVPHMKSE----- ---EARLSTFNN-WPA---DS--PVRPEDLAE--------AGMY---YI----------G IDDNVQCF---------------------------------------------------- ----------CCGGGLSGWEQGDDPWS---EHAKYYSNCFFFLGHNVGN----------- ----------VPLTTPRPRAN--------------------------------------- ----------------------------------VHPTDTFEGRLDSF-K---GR---QH PIDPERLA-----RAGFYST-GEQDRVMCF------------------------------ ------------RCGG------------------------GVKAWMPDEDPWEEHARHYP --GC---SFLLAE-KGEE-------------YVSSVQLR----------YPKRPTQ---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------NGFSSHESGSSAQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ALIHGSSD-MFEKA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------DDPMTELEKLQ------ ----------REKLCKVCMD---------------------------------------- ---SDISIVFIPCGHLVTCQKCSASLDKC------------------------------- ------------------------------------------------------------ -----------------------------PICCATITQ---KIKTYNA------------ ------------------------------------------------------------ ------------------- >P_troglodytes_ENSPTRP00000007250 ----------------------------MNIVEN-SIFLSNLMKSAN-TFEL-KYDLSCE LYRMSTYSTFPAGVPVS-ERSLARAGFYYTG---------------VNDKVKCFCCGLML DNWKRGDSPIEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNS------------- --THS-LLPGTENSGY-FGGSYSN-SPSNPVNSRANQDFSALM-RSSYHCAMNNE----- ---NARLLTFQT-WPL---T---FLSPTDLAK--------AGFY---YI----------G PGDRVACF---------------------------------------------------- ----------ACGGKLSNWEPKDNAMS---EHLRHFPKCPFIENQLQDT----------- ----------SR------------------------------------------------ ---------------------------YTVS---NLSMQTHAARFKTF-F---NWPS-SV LVNPEQLA-----SAGFYYV-GNSDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWVQHAKWFP --RC---EYLIRI-KGQE-------------FIRQVQAS----------YPHLLEQ--LL STSDSPRDENTESS---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------II HFEPGEDHSEDAIMMNTPVV---NAAVEMGFSRSLVKQTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------RKILATGENYRLVNDL------------ ----VLDLLN--AEDEIREE-ERERATE---EKES--NDLLLIRKNR---MALFQHLTC- VIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKG----------------- ------------------------------------------------------------ --------------------------------------------------------NIAA TVFRNSLQEADAVLYEHLFVQQDIK-----YIPTEDV--SD--LPVEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---KEVSIVFIPCGHLVVCKDCAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRSTIKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >A_carolinensis_ENSACAP00000012475 ----------------------------LIIMNTFDTFAAKLKNVPD-VGQL-KYDLSCE LFRMSTFSTFPLHVPVS-ERSLARAGFYYTG---------------VKDKVKCYSCGLML DNWKKGDNPLDKHKQLYPSCSVVQNLTSLNNLGSSFYSAFSPPSLSV---------GHSS SHSPQ-QTPNLDQVGY-FSGSFSS-VPQEL--PKLTEGISHVR-PKVANSAMSSE----- ---EARLLTFKT-WPL---T---FLSPSSLAK--------AGFY---YI----------G PADKVACF---------------------------------------------------- ----------VCGGHLGNWEPKDNAMS---EHRRHFPTCPFVE-QTQSQ----------- ----------PG------------------------------------------------ ---------------------------FTVS---NLSMQTYRARVGTF-E---NWPM-TV PVLPQRLA-----DAGFYYV-GRNDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWEEHAKWFP --RC---EYLIHR-KGQE-------------FVRCVQAR----------FPHLLEQ--LL STSDIPVDENTSPP---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------II RFEPGENGSEDEVIMKTPVV---EAALEMGFRRRLVKQIVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SKILRTGESYKSINDL------------ ----VSDLIA--ADDEKRDD-EKEPQME---ESTS---DLSLIRKNR---VALFQRLTC- VLPILECLLASKAISSLEYQVIKQKTQTPLQARELIDTILVKG----------------- ------------------------------------------------------------ --------------------------------------------------------NKAA NIFRNCIQESDPVLYQDLFVEKNMT-----YIPA-DV--SG--LSMEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---KEVSIVFIPCGHLVVCKECAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRGTIKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >H_sapiens_ENSP00000376897 ----------------------------MNIVEN-SIFLSNLMKSAN-TFEL-KYDLSCE LYRMSTYSTFPAGVPVS-ERSLARAGFYYTG---------------VNDKVKCFCCGLML DNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNS------------- --THS-LLPGTENSGY-FRGSYSN-SPSNPVNSRANQDFSALM-RSSYHCAMNNE----- ---NARLLTFQT-WPL---T---FLSPTDLAK--------AGFY---YI----------G PGDRVACF---------------------------------------------------- ----------ACGGKLSNWEPKDNAMS---EHLRHFPKCPFIENQLQDT----------- ----------SR------------------------------------------------ ---------------------------YTVS---NLSMQTHAARFKTF-F---NWPS-SV LVNPEQLA-----SAGFYYV-GNSDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWVQHAKWFP --RC---EYLIRI-KGQE-------------FIRQVQAS----------YPHLLEQ--LL STSDSPGDENAESS---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------II HFEPGEDHSEDAIMMNTPVI---NAAVEMGFSRSLVKQTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------RKILATGENYRLVNDL------------ ----VLDLLN--AEDEIREE-ERERATE---EKES--NDLLLIRKNR---MALFQHLTC- VIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKG----------------- ------------------------------------------------------------ --------------------------------------------------------NIAA TVFRNSLQEAEAVLYEHLFVQQDIK-----YIPTEDV--SD--LPVEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---KEVSIVFIPCGHLVVCKDCAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRSTIKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >T_nigroviridis_ENSTNIP00000006583 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MRRE----- ---KDRIRTFRE-WPA---DA--AVAPADLAK--------AGFF---FL----------G PRDAVQCF---------------------------------------------------- ----------CCGGILRCWVQGDSPGD---EHRRHFPTCCFILGRAVGN---IPLQAGSS DSVD-------------------------------------------------------- ------------------------------------EMEAEDSRLTTF-H---NWPT-EA SVQPDVLA-----RAGFFYT-GHGDNVKCY------------------------------ ------------YCDG------------------------GLRNWEPGDDPWQEHAKWFP --RC---EFLIQT-RGQE-------------YISNIQDA----------HFHLGDT--LS SSS----RDIGPRNASPLP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------DM IGGLAASSA-----LLSPVV---QTVLQMGFDSSLVESLVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------TKYLLTGRQYTSVSNL------------ ----VSDVLQ--AEQEDRET-APQSRVS---KSGGCLRWCSYCVCSCCDYLVCAFQSQRR GRAPVL------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------LASE HIWPLEKKLSHLSFLREPALIPLTV--------------NE--PSPEELLRQLQ------ ----------EERTCKVCMD---------------------------------------- ---KLVSIVFIPCGHLVVCSDCATSLRHC------------------------------- ------------------------------------------------------------ -----------------------------PICRAVIRG---SVRAFMS------------ ------------------------------------------------------------ ------------------- >M_domestica_ENSMODP00000000728 --------THKTTSQRKTCPLLFPKYSIMSVVED-GVLLSHLMSSD--THEM-KYDLSCE LYRMSTYSAFPVNVPIS-ERSLARAGFYYTG---------------VNDRVKCFCCGLML DNWKQGDNAIDKHKQLYPSCAFIQNLISVN--LGSSQSTFSSSVNNA------------- --TRS-LSLSSEQSGY-FSGSYSS-FPLEPVTSRGVEDLSPLN-TSPYSYSMSTE----- ---EARILTYQA-WPL---T---FLSPLDLAR--------AGFY---YI----------G PGDMVACF---------------------------------------------------- ----------ACGGKLSNWEPKDDAMS---EHRRHFPHCPFLESQIQET----------- ----------SR------------------------------------------------ ---------------------------FNVS---NLSMQTHAARVKTF-V---TWPP-QI PVHPEQLA-----NAGFYYV-GRNDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWVEHAKWFP --R----QYLIRM-KGQE-------------FVDQVQAR----------YPHLLEQ--LL STSDIPGDENAELP---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------II HFGPGENNSEDTVMMNTPVI---KAALEMGFSRSLVKQIVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SKILTTGENYKTVNEV------------ ----VSDLLN--AEDEKRKE-EKERQTE---EMAS--DDLTLIRKNR---MALFQHLTC- VLPILDSLLTSGVINEQEHDVIKQKTQTSLQARELIDTILVKG----------------- ------------------------------------------------------------ --------------------------------------------------------NAAA SVFKNCLREIGSVLYNNLFVEKNMK-----YIPTEDV--SG--LPMEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---KEVSIVFIPCGHLVVCKECAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRGIIKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >M_mulatta_ENSMMUP00000004533 ----------------------------MNIVEN-SIFLSNLMKSAN-TFEL-KYDLSCE LYRMSTYSAFPAGVPVS-ERSLARAGFYYTG---------------VNDKVKCFCCGLML DNWKRGDSPVEKHKKLYPSCRFVQSLNSVNNSEATSQPAFPSSVTNS------------- --THS-LLPGTENSGY-FSGSYSS-FPSNPVNSRANQDFSALM-RSSYHCAMNNE----- ---KARLLTFQT-WPL---T---FLSPTDLAK--------AGFY---YV----------G PGDRVACF---------------------------------------------------- ----------ACGGKLSNWEPKDNAMS---EHLRHFPKCPFIENQLQDT----------- ----------SR------------------------------------------------ ---------------------------YTVS---NLSMQTHAARFKTF-F---NWPS-SV LVNPEQLA-----SAGFYYV-GNSDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWVEHAKWFP --RC---EYLIRI-KGQE-------------FIRQVQAS----------YPHLLEQ--LL STSDSPEDENAESS---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------II RFEPGEDHSEDAIMMNTPVV---NAAVEMGFSRSLVKYTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------RKILATGENYRLISDL------------ ----VLDLLN--AEDEMREE-ERERATE---EKES--NDLLLIRKNR---MALFQHLTC- VIPILDSLLTARIINEQEHDVIKQKTQTSLQARELIDTILVKG----------------- ------------------------------------------------------------ --------------------------------------------------------NIAA TVFRNSLQEADAVLYERLFVQQDIK-----YIPTEDV--SD--LPVEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---KEVSIVFIPCGHLVVCKDCAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRSTIKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >T_guttata_ENSTGUP00000013125 ----------------------------LNTVED-SPFLTSIMRQSALCDEL-KYDLSCE LYRMSTFSTFPMNTPVS-ERSLARAGFYYTG---------------VQDKVKCFSCGLTL DNWQPGDNAMEKHKQLYPRCSFVQRMLSDNNVGLSSRSAFSPSIANS---------LPPS LHSIA-LSPSLEQVGY-FSGSFSS-FPQDPVTTRAAEDLSFLS-PKLHNNSMRTE----- ---DARLCTFQS-WPL---T---FLSPTDLAK--------AGFY---YL----------G TADKVACF---------------------------------------------------- ----------TCGGQLYNWEPKDNAVS---EHRRHYPNCPFVENLIRDQ----------- ----------QS------------------------------------------------ ---------------------------FNVS---NVSMQTHEARVKTF-L---NWPT-RI PVQPEQLA-----DAGFYYV-GRNDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWIEHAKWFP --RC---EYLLRV-KGRE-------------FVDQIQAR----------FPHLLEQ--LL STSDPPVNENLDPP---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------II HFEPGESHSEDAIMMNTPVV---KAALEMGFSRRLIKQTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SKILVTGENYKTVNDL------------ ----VSDLLM--AEDETIQE-EKEKQLE---EVAS--DDLYLIQKNR---MALFQRLTC- VLPILGSLLSAKVITELEHDVIKQKTQIPLQARELIDTVLVKG----------------- ------------------------------------------------------------ --------------------------------------------------------NEAA SIFRNCLRDCDPVLYKDLFVEKTIK-----YVPTEDV--SG--LPMEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---KEVSIVFIPCGHLVVCKECAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRGIIKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >C_intestinalis_ENSCINP00000002256 ----------------------------------------------------------ME SYRLSTFMKYPQDTPVN-PRHLAAAGFHYTG---------------YKDRVKCFCCGLCV ESWCVGDD-VKSPRWHRSNCEFILGQDCGNQPI-DHMVWLQVVCSAT--------LCDHL VQL-G-QG---------------------------------------------------- -----------------------GIYSETLA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GYVT---CPYMRNEESRFETFDH---RWPASNV RASPRQIA-----KAGFFFL-GDRDRVKCW------------------------------ ------------YCNG------------------------GLQNWDPDDEPWTEHAKWFP --TC---EFLLQR-KGPD-------------FVHRMVSL----------YPNLPRP--IL RGPFDVPPRA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --EVAKQQEQVNKFMLGDLV---KSATEMGFETSVIRRVVT------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------RRLTSGGNLYTSVADL------------ ----VDDITA--NENEPNSD-DDDETNA---SQPSQTTTVKTPD---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VTPSMEARIRELQ------ ----------EERKCKICLD---------------------------------------- ---KVADIVFVPCGHLCTCTECAEALRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRSKIER---GIKTYMS------------ ------------------------------------------------------------ ------------------- >C_intestinalis_ENSCINP00000000466 --------------------MELANNLFSDIETDGMKVNTTSEPSDKRCVYITPGQKERE DYRITTFNKFPSNKPVD-KMKLSSNGFLYTG---------------FKDRVKCFRCGQCV EGLNGTEN-MGLPGWHKPDCEFANGTDTTNVPLLRHKIQQNLPSLQN------------- --------------------------ASFVQSIPNQDQTTLSAGELLKFGNIDQT----- ---TNQVVTPRN-LP-------VQQSSNQFGQ----------MYQTATI----------H KPHLQVPF---------------------------------------------------- ----------SVLQSTRATEPAPRC-----AENSQFPC---------------------- ------------------------------------------------------------ ---------------------------SNPR---NPHMKSERVRLQTFMNNLGKWSSHGI VTTPEQMA-----DAGLFYL-SDRDRTKCW------------------------------ ------------YCNG------------------------GLQNWEPNDDPWYEHAKWFP --EC---EFVLQQ-KGEL-------------YVHRIARQ----------FPNLNRP--RI SNPYQLFGRSNND----------------------------------------------- ------------------------------------------------------------ -----------------------------------------VPPPQPQPQSPGPVIIDPQ EEQRKLKSKIDEEMESSAVV---DGAKQMGFEEKEIKRAIT------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------KNMKENGKSFSTLLSL------------ ----VDAILA--DSDDDNTS-SEEQSEA---PTAPETTLTFNTDQ--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------QSTASELQRLE------ ----------MARFCKICRQ---------------------------------------- ---KEAVVVLLPCGHLSCCDTCGKKITKC------------------------------- ------------------------------------------------------------ -----------------------------PTCKLAVTD---KVHSFIA------------ ------------------------------------------------------------ ------------------- >T_rubripes_ENSTRUP00000043752 --LLSPDPPLGGPTFTLILLCFHTKMETLVQLKN-NPFLMGLCRNCP-PPDL-QYDNSSE LYRISTFARFP-TSGVT-ERSLARAGWFYTG---------------VGDRVQCFKCNVTA EGWQAGDCPTEKHRQLSPSCSFIQSLPSTSNLLSSSHSAFSPLRIAPAIPLSG---AGPA VPNPS-ANQGEEPVGY-LNMGFSAPPPSSPLISRGVEDMSHQR-PTCHNPNMRRE----- ---QDRLESFHS-WTL---T---IITPAELAK--------AGFY---YL----------S QGDRVACF---------------------------------------------------- ----------SCGGQLSNWEPGDRAMS---EHQRHYPNCRFVRGDRADNISLAGA-APG- ----------GL------------------------------------------------ ---------------------------TNVS---NPAMQQSEERLLTF-V---NWPS-RI PVRPDQLA-----KAGFYYV-GRNDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWVEHAKWFP --RC---EYLLQE-RGQD-------------FVHQIQAR----------FPRLFEQ--LL TNGDTTSREFVDPP---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------VV HLGPGEERSEDAVMMNTPVI---KSALEMGFERSLVKQTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SKILTSGENYRTVQEL------------ ----VSDLLS--AEDQKREE-EKEMLAE---AMASALDGFTFVKRHQ---AALIQRLKS- VEPVLEHLREQNVLSHEEYSGLKAQTSAQQQTARLIELVLTKG----------------- ------------------------------------------------------------ --------------------------------------------------------NAAA EVFRNWIQKNDVHLLRDLMAQSSEA-----SSPSQDL--SD--LPMEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---KEVNIVFIPCGHLVVCKECAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRGLVKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >G_aculeatus_ENSGACP00000024474 ---------------------------VPPSSILSSSIMCALRQDNQLESDH-MADFSEI NNRLDSFRGSSLAQQVP-AERLARAGFYYTG---------------NADRVCCFSCEKTV ENWCRGDTPLERHKEVSPSCIFLSCTQRTNFNLSCENRLTNGFSYNE------------- ----------------------EEEDLEYRLRRGEVVDES----TYPMAPHMKSE----- ---EARLQTLST-WPS---SS--PVRPRDLAQ--------AGLY---YL----------G QSDRVQCF---------------------------------------------------- ----------CCGGMLAGWEVGDTAWE---EHNKHFPNCFFMLGHDVGN----------- ----------IPLHRGGVEEENSGRQ---------------------------------- ---------------------------HASA---CVPMGSFEKRLGSF-A---GV---LH PIDHERLA-----RAGFYSA-GTGDRVLCF------------------------------ ------------RCGG------------------------GLKGWQPEEDPWEEHAKHYP --GC---SFLLTE-KGQE-------------YVNSIQLQ----------DPRRNRT---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------NGFSGHGNGKKGA------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AVGHGSEG-RWDD----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VDPLEKLRELQ------ ----------REKLCKICMD---------------------------------------- ---RDIGIVFIPCGHLVTCTKCSESLIKC------------------------------- ------------------------------------------------------------ -----------------------------PICCGAITQ---KIQTYIA------------ ------------------------------------------------------------ ------------------- >P_pygmaeus_ENSPPYP00000004355 ----------------------------MNIVEN-SIFLSNLMKSAN-TFEL-KYDLSCE LYRMSTYSTFPAGVPVS-ERSLARAGFYYTG---------------VNDKVKCFCCGLML DNWKRGDSPIEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNS------------- --THS-LLPGTENSGY-FSGSYSS-FPSNPVNSRVNQDFSALM-RSSYHCAMNNE----- ---NARLLTFQT-WPL---T---FLSPTDLAK--------AGFY---YI----------G PGDRVACF---------------------------------------------------- ----------ACGGKLSNWEPKDNAMS---EHLRHFPKCPFIENQLQDT----------- ----------SR------------------------------------------------ ---------------------------YTVS---NLSMQTHAARFKTF-F---NWPS-SV LVNPEQLA-----SAGFYYV-GNSDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWVQHAKWFP --RC---EYLIRI-KGQE-------------FIRQVQAS----------YPHLLEQ--LL STSDSPGDENAESS---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------II RFEPGEDHSEDAIMMNTPVV---NAAVEMGFSRSLVKQTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------RKILATGENYRLVNDL------------ ----VLDLLN--AEDEIREE-ERERATE---EKES--NDLLLIRKNR---MALFQHLTC- VIPILDSLLTARIINEQEHDVIKQKTQTSLQARELIDTILVKG----------------- ------------------------------------------------------------ --------------------------------------------------------NIAA TVFRNSLQEADAVLYEHLFVQQDIK-----YIPTEDV--SD--LPVEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---KEVSIVFIPCGHLVVCKDCAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRSTIKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >B_taurus_ENSBTAP00000034604 ----------------------------MNIVEN-SVFLSNLMKSAN-MFEL-KYDFSCE LYRMSTYSTFPAGVPVS-ERSLARAGFYYTG---------------VKDKVKCFCCGLML DNWKQGDNPIEKHKKLYPSCSFVQNLNSINVSGASSQPTFHYSLTNS------------- --THS-LLPSLENSGY-FSGSYSS-FPSNLLNSGPNQDFSALR-ISSYPCAMNTE----- ---KARLLTFQM-WPL---T---FLSPTDLAK--------AGFY---YI----------G PGDRVACF---------------------------------------------------- ----------ACGGTLSNWEPKDDAMS---EHLRHFPNCPFLGNQLQGT----------- ----------SR------------------------------------------------ ---------------------------YTAS---NLSMQTYAARIKTF-C---SWPS-SV PVHPEQLA-----SAGFYYV-GHSDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWVEHAKWFP --RC---EYLIQI-KGQE-------------FISRVQAS----------YPHLLEQ--LL STSDNPEDENTESP---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------RI ERNANQNHYEDMVQLSHPYM---TTGKTIGLTRRTFVGTVI------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CHILTTGLNYLTICQL------------ ----LFKLPN--PDRSFVQQ-EVNKDTS---ENEK--DDLSLIRKNR---MALFQHLTC- VLPILDSLLTARVISEQEHDVIKQKTQTSLQARELIDTILVKG----------------- ------------------------------------------------------------ --------------------------------------------------------NFAA TIFKNSLQEIDPMLYKRLFVQQDIK-----YIPTENV--SD--LPMEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---KEVSIVFIPCGHLVVCKDCAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRGTIKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >D_rerio_ENSDARP00000065554 IYMRTHTQGMTIKPFSLLAIPFPISLSQMEILQN-SAFLRGLCRTSG-PADL-QYDNSSE LFRISTYAKFPTTAAVT-ERSLARAGFYYTG---------------LGDRVQCFRCNVTA DNWQSGDCPAERHKQLSPNCSFIQSLPATANLLSSSHSAFSPLRNVAVLQLSAPATAAPS TTAPSTSGQTEEQVGY-LNMGFTNLAPSSPISSRGVEDMSHQRPPACHNPGMRRE----- ---QERLDTFQN-WTL---A---TVTPAELAK--------AGLY---YL----------G QGDRVACF---------------------------------------------------- ----------SCGGQLGSWEPGDRAVS---EHQRHYPNCRFVRGDRADNIPLSGG----- ----------GL------------------------------------------------ ---------------------------SNVS---NSAMQQCEERLLTF-V---NWPS-RI PVRPDQLA-----KAGFYYV-GRNDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWVEHAKWFP -SRC---EYLLQE-KGQE-------------FVHQIQAR----------FPRLFEQ--LL TNGDSNSREFVDPP---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------VV HLGPGEDRSEDAVMMNNPVV---KSALEMGFERGLVKQTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SKILTSGENYKTVQEL------------ ----VSDLLS--AEDEKREE-ERELLAE---EMAS--DGFTFLKKHH---AALSQRLKS- VQSLMDHLLEENVISQKEYDSIRNCTSVKQQTGQLIDLVLSKG----------------- ------------------------------------------------------------ --------------------------------------------------------NAAA EVFRNWIKKNDVYLLRELMAQTNEA-----ASPSQDL--SD--LPMEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---KEVNIVFIPCGHLVVCKECAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRGMVKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >E_caballus_ENSECAP00000010270 ----------------------------MNIVEN-SVFLSNLMKSAN-MFEL-KYDFSCE LYRISTYSTFPPGVPVS-ERSLARAGFYYTG---------------INDRVKCFCCGLML DNWKQGDNPTEKHKKLYPSCSFVQNLNSVNISGATSQLAFSSSVTNS------------- --THS-LLPSLENSGY-FSGSYSS-FPSNPVNSGPNHDFSALR-TSPYHCAMNTE----- ---KARLLTFQM-WPL---T---FLSPTDLAK--------AGFY---YI----------G PGDRVACF---------------------------------------------------- ----------ACGGKLSNWEPKDDAMS---EHLRHFPNCPFVENQFEDT----------- ----------SR------------------------------------------------ ---------------------------YTVS---NLSMQTHAARFRTF-C---NWPS-SV QVPPEQLA-----SAGFYYM-GHSDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWVEHAKWFP --RC---EYLIRI-KGQE-------------FISRVQAN----------YPHLLEQ--LL STSDNPEDENAESP---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------II HFGPGENHSEDAVMMNTPVV---KAALEMGFSRRLIKQTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SKILTTGENYKTISDL------------ ----VLELLN--AEDEMREE-EKERATE---EKES--GDLSLIRKNR---MALFRHLTC- VLPILDSLLTARVINEQEYDVIKQKTQTSLQSRELIDTILVKG----------------- ------------------------------------------------------------ --------------------------------------------------------NFAA TIFKNSLQEIEPTLYKHLFVQQDIK-----YIPTEDV--SD--LPMEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---KEVSIVFIPCGHLVVCKDCAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRGTIKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >G_gorilla_ENSGGOP00000008137 ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------RNSF------------- --AHS-LSPTLEHSSL-FSGSYSS-LSPNPLNSRAIEDISSSR-TNPYSYAMSTE----- ---EARFLTYHM-WPL---T---FLSPSELAR--------AGFY---YI----------G PGDRVACF---------------------------------------------------- ----------ACGGKLSNWEPKDDAMS---EHRRHFPNCPFLENSL-ET----------- ----------LR------------------------------------------------ ---------------------------FSIS---NLSMQTHAARMRTF-M---YWPS-SV PVQPEQLA-----SAGFYYV-GRNDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWVEHAKWFP --RC---EFLIRM-KGQE-------------FVDEIQGR----------YPHLLEQ--LL STSDTTGEENADPP---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------XX XXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXX------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------XXXXXXXXXXXXXXXX------------ ----XXXXXX--XXXXXXXX-XXXXXXX---XXXX--XXXXXXXXXX---XXXXXXXXX- XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----------------- ------------------------------------------------------------ --------------------------------------------------------XXXX XXXXXXXXXXXXXXXXXXXXDKNMK-----YIPTEDV--SG--LSLEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---KEVSVVFIPCGHLVVCQECAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRGIIKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >O_latipes_ENSORLP00000012199 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MRRERERLQTF-Q---NWPD-EA PVTSEDLA-----KAGFYFL-GSEDKVKCF------------------------------ ------------FCDG------------------------GLRNWEPGDDPWQEHAKWFP --RC---EFLIHS-RGQD-------------YINNIQDA----------HFHLGNS--GE KLLYLHFKLA-------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------DM VGGLGASSA-----MLSPVV---QTVLQMGFEDSLVQSLVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------TKYLLTGQHYTSVSDL------------ ----VTDVLQ--AEEEERQR-GANSRGS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------AV--------------KE--ASPEELLRQLQ------ ----------EERTCKVCMD---------------------------------------- ---KLVSIVFIPCGHLVVCGDCAASLRHC------------------------------- ------------------------------------------------------------ -----------------------------PICRAVIRG---SVRAFMS------------ ------------------------------------------------------------ ------------------- >R_norvegicus_ENSRNOP00000007702 ----------------------------MNMVQG-SAFLAKLMKSAD-TFEL-KYDFSCE LYRLSTYSTFPAGVPVS-ERSLARAGFYYTG---------------VNDKVKCFSCGLML DNWKQGDSPIEKHRKLYPSCSFVQTLNPANSLEASPQPPLPSTATST------------- --MPS-GFAASESTGY-FSGSYSS-FPSDPVNFRANQDCPAFS-TSPYHFAMNTE----- ---KARLLTYQT-WPL---S---FLSPAELAK--------AGFY---YT----------G PGDRVACF---------------------------------------------------- ----------ACGGKLSNWDRKDDPLS---EHRRHFPSCPFLKDVGQFT----------- ----------SQ------------------------------------------------ ---------------------------YTVS---NLSMQTHAARVRTF-S---TWPS-SA LVHPQELA-----SAGFYYT-GHSDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWVEHAKWFP --RC---EYLIRI-KGQE-------------FVGQVQAG----------YPHLLEQ--LL STSDSPEDETGEAA---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------IV HLGPGEN-WEDAVMMNTPVV---KAALDMGFSRSLVRQTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------RQILATGENYRTVSDL------------ ----VIGLLD--AEDEMREE-QTEQEAE---EEES--DDLTLIRKNK---MVLLQHLTP- VTPILDCLLSARVITEQEYDAVKQKPHT-LQARTLIDTVLAKG----------------- ------------------------------------------------------------ --------------------------------------------------------NTAA TSFRNSLQEIDPGLYRDIFVRQNIR-----SLPTDDI--AA--LPMEEQLRKLQ------ ----------EERTCKVCMD---------------------------------------- ---REVSLVFIPCGHLVVCKECAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRGTIKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >T_rubripes_ENSTRUP00000010298 -----------------------MNPFDNMQLKKEITMEDQQHDSGTLETDS-AEDFSLI TSRLESFRGSNLVQLVP-AERLARAGFHFIG---------------PSDRVRCFSCHKTV ENWCTGDRPVERHKEVSPFCKFLSCIYRTSSNPIPGTSLTNGSAYNE------------- ----------------------EAEDMEYRLRTGQVVDES----IYPVVPHMRSE----- ---ESRLHTFST-WPL---TA--PVSPCDLAQ--------AGLY---YL----------G QCDQVQCF---------------------------------------------------- ----------CCGGTLADWEIGDSAWA---EHSKHFPFCFFILGHDVGN----------- ----------IPFQGSIEEEGSGRL----------------------------------- ---------------------------HTSA---AVHMGTFEERLRSF-A---GV---NH PLNIERLA-----RAGFYSN-GTEDMVLCF------------------------------ ------------CCNG------------------------GLKGWQPEEDPWEQHARHYP --GC---RFLLAE-KGQE-------------FVNHIQLQ----------MPRQKKA---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------NGFSAATNGTDTQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TIIHFLRNAIGQALES-SIRTVLI---ARHTVNLLLVQKSSPRVTAAMNRQY---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------DDPLEKLQKLQ------ ----------REKLCKICMD---------------------------------------- ---KDIDIVFIPCGHLVTCNECSVSLIKC------------------------------- ------------------------------------------------------------ -----------------------------PICCGDIRQ---KVKTYIT------------ ------------------------------------------------------------ ------------------- >M_domestica_ENSMODP00000000705 ----------------------------MNLVEN-IMFLSNMNISN--LYEL-KYDFSCE LYRISTYSAFPVNVPVS-ERSLARAGFYYTG---------------VNDRVKCFCCGLML DNWKQGDNAIDKHKQLFPSCAFIQNLTSVNNLESNSQSALSSSLNSA------------- --SCS-LSPSSEQSGY-FSGSYSS-FPLEPVTSRGVEDLSPLN-TSPYSYSMSTE----- ---EARILTYQA-WPL---T---FLSPLDLAR--------AGFY---YI----------G PGDMVACF---------------------------------------------------- ----------ACGGKLSNWEPKDDAMS---EHRRHFPHCPFLESQIQET----------- ----------SR------------------------------------------------ ---------------------------FNVS---NLSMQTHAARVKTF-V---TWPP-QI PVHPEQLA-----NAGFYYV-GCNDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWVEHAKWFP --RC---EYLIEM-KGQQ-------------FINQIQAS----------YPHLLEQ--LL STSDVPVDENAGLP---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------II HFGLGENHAEDAVMMNTSAV---RSALEMGFQRRLIKQTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SKILTTGENYKTVSDL------------ ----VSDLLK--AEDETREE-DE--QAE---EIES--DDLSLIQKNR---MALFQHLTC- VLPVLNCLLTASVINEQEYDVIKQKTQISLQVRELIDTIIVKG----------------- ------------------------------------------------------------ --------------------------------------------------------NIAA NIFKKCLRDFDPVLYENLFVEKNMK-----YIPTEDV--SG------------------- ---------------KIL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------- >X_tropicalis_ENSXETP00000048002 --------------------------MANEILDR-RPDLAKRLKSNPSMCKI-TLEFSCE LYRLSTFSTFPSNTHVS-ERNLAKAGFYYTG---------------QDDKVKCFTCGLML DNWKKGDNAFEKHKKLYPSCSFIQNVPSVN-LGASLYSAFSPPASNS---------TP-- --MHA-ASAENDKVEA-ITLKYSS-IPQDPVTLRGIEDLSHVR-ISEY---MYTE----- ---EARLNSFQE-WSN---M---FLTPAELAK--------AGFY---FV----------G PGDKVACF---------------------------------------------------- ----------TCDGKLNNWEPNDNAMS---EHRRHFPNCPFVKSSTRVS----------- ----------SR------------------------------------------------ ---------------------------FSVS---NVSMQASSARLKTF-A---SWPP-RI PISPTRLA-----EAGFYYV-GRNDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWVEHAKWFP --RC---EYLLHI-RGQD-------------YVQEVQER----------YPHLLDQ--LL SSSENQ-NEAKNIP---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------II RLG-TENSQEDEIMMSTPMV---QTALEIGFNRRLVKRTIQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SKMLTSGENYSQLDDL------------ ----ISDLLI--AQEEQTEE-ERNRQAE---ENSL--DDISVIRKSR---MALSQHIASR SIPILDYLLSSNDITAAEYEAIKLKTQPILQAQEMIETIITKG----------------- ------------------------------------------------------------ --------------------------------------------------------KTAV QTLKNCLQKHDPNLFRQLFTEQSLK-----CISLDDY--SD--LSMEEQLRRLQ------ ----------EERTCKICMD---------------------------------------- ---QEVSIVFIPCGHLVVCKDCAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRGTIKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >A_gambiae_AGAP011326-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------MSS---------------------------A SGSEVQPA---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EMPY---MPEFAVLDARIRSF-E---SWRF-GH MQNPTRLA-----VAGFYYT-GTDDEVRCF------------------------------ ------------QCDA------------------------GLRDWLVTDDPWQEHARCFA --EC---TFLRLV-FGAD-------------TVDEVLRN--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------GIAGFKNGANTATT-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----PSATVSGPIDETSSEL-A-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------QRLREENKRMK------ ----------QERECKICLT---------------------------------------- ---QEAEVVFMPCAHLLSCVQCSTGVDNC------------------------------- ------------------------------------------------------------ -----------------------------PVCRAVITH---RFRAFIC------------ ------------------------------------------------------------ ------------------- >O_latipes_ENSORLP00000006992 ----------------------------LVQLKN-SKFLMGLCRNGP-PSDL-QYDNSSE LFRFSTFARFP-TSVVT-ERSLARAGWFYTG---------------VGDRVQCFRCNVTA EGWLAGDCPTEKHRQLSPTCPFIQSLPSTTNLLSSSHSAFSPLRIAQAMPVSSERRQGPA ASNPS-GGQSEEAVGY-LNMAFSAPPPSSPLASRGVEDLSHQR-PTCHNPSMRRE----- ---QDRLDSFQP-WAI---S---IITPAELAK--------AGFY---YL----------G QNDRVACF---------------------------------------------------- ----------SCGGQLSNWEPGDRAVS---EHQRHYPNCRFVRGDRADNVPLVAG--ATA LSAAASSGALAL------------------------------------------------ ---------------------------TSVS---NPSMQQSEDRRLTF-V---NWPS-RI PVRPEQLA-----KAGFYYV-GRNDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWVEHAKWFP --RC---EYLLQE-KGQD-------------FVHQIQAR----------FPRLFEQ--LL TNGENSSREFVDPP---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------VV HLGPGEDRSEDAVMMNTPVI---KSALEMGFERSLVKQTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SKILTSGENYRTVQEL------------ ----VSDLLS--AEDQKREE-EREMLAE---AMAS--DGFTFVKRHQ---AALIQRLKS- VEPVLEHLREQNVLSAEEYGSLLAQTSAQQQTARLIELVLNKG----------------- ------------------------------------------------------------ --------------------------------------------------------NAAA EVFRNWIQKNDVHLLRDLMAQSNEA-----SSPSQDL--SD--LPMEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---KEVNIVFIPCGHLVVCKECAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRGLVKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >M_musculus_ENSMUSP00000104503 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------MFSPADLFR--------AAVF---SM----------G PESRARDS---------------------------------------------------- ----------VRGPELSHREDGSGRTQ---EQDKPHCPCNHVLGQ--------------- DCLDGQILGQLRPLSEEEESSGAAFL---------------------------------- ---------------------------GEPA---FPEMDSEDLRLASF-Y---DWPS-TA GIQPEPLA-----AAGFFHT-GQQDKVRCF------------------------------ ------------FCYG------------------------GLQSWERGDDPWTEHARWFP --RC---QFLLRS-KGRD-------------FVERIQT-----------YTPLLGS--WD QREEPE------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DA VSATPSAPAHG------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SPELLR--SRRETQPE-DVSEP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GA--KDVQEQLRQLQ------ ----------EERRCKVCLD---------------------------------------- ---RAVSIVFVPCGHF-VCTECAPNLQLC------------------------------- ------------------------------------------------------------ -----------------------------PICRVPICS---CVRTFLS------------ ------------------------------------------------------------ ------------------- >M_musculus_ENSMUSP00000013949 ----------------------------MNMVQD-SAFLAKLMKSAD-TFEL-KYDFSCE LYRLSTYSAFPRGVPVS-ERSLARAGFYYTG---------------ANDKVKCFCCGLML DNWKQGDSPMEKHRKLYPSCNFVQTLNPANSLEASPRPSLPSTAMST------------- --MPL-SFASSENTGY-FSGSYSS-FPSDPVNFRANQDCPALS-TSPYHFAMNTE----- ---KARLLTYET-WPL---S---FLSPAKLAK--------AGFY---YI----------G PGDRVACF---------------------------------------------------- ----------ACDGKLSNWERKDDAMS---EHQRHFPSCPFLKDLGQSA----------- ----------SR------------------------------------------------ ---------------------------YTVS---NLSMQTHAARIRTF-S---NWPS-SA LVHSQELA-----SAGFYYT-GHSDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWVEHAKWFP --RC---EYLLRI-KGQE-------------FVSQVQAG----------YPHLLEQ--LL STSDSPEDENADAA---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------IV HFGPGES-SEDVVMMSTPVV---KAALEMGFSRSLVRQTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------WQILATGENYRTVSDL------------ ----VIGLLD--AEDEMREE-QMEQAAE---EEES--DDLALIRKNK---MVLFQHLTC- VTPMLYCLLSARAITEQECNAVKQKPHT-LQASTLIDTVLAKG----------------- ------------------------------------------------------------ --------------------------------------------------------NTAA TSFRNSLREIDPALYRDIFVQQDIR-----SLPTDDI--AA--LPMEEQLRKLQ------ ----------EERMCKVCMD---------------------------------------- ---REVSIVFIPCGHLVVCKDCAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRGTIKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >X_tropicalis_ENSXETP00000035327 --------------------------LAEFVLKEEMTCQCPKMSDGAYDMDV-DQNYFEE EVRLASFANFPSSYPVS-APALARAGFYYTG---------------DGDRVKCFSCLAMV EGWQHGDTAIGKHRKISPNCKFINGFNNLRSDCILTQVPVMQNGFQN------------- -----------SAEDL-AERSSSEIMADYLLRTGRVVDMSTP--KYPRHMEMCSE----- ---EARLQTFQN-WPA---YS--PLTPKELAN--------AGLF---YT----------G INDQVKCF---------------------------------------------------- ----------CCGGKLMNWEPSDKAWT---EHKKHFPECYFVLGRDVGN----------- ----------VATEANTHGGRRRG------------------------------------ ---------------------------SELA---CPAMNDYNARLETF-S---SW---SF PIDKETLA-----KAGFYSI-GDGDATKCF------------------------------ ------------HCGG------------------------VLNCWSATDDPWEEHAKAYP --GC---KFLIDE-KGQH-------------FINHAQLK----------RPILHKA---- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------N SADASPALPKDSNLLKSPLV---TNAQQMGFPLEEIKKVMG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QKLKTTGKNYTCVEEF------------ ----VSDLC---AQKETVLE-KPKEIE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ISLEEKLRQLE------ ----------EEKICKVCMD---------------------------------------- ---RRISIVFIPCGHLVACAVCADVLDKC------------------------------- ------------------------------------------------------------ -----------------------------PICCTIVER---RQKIFMS------------ ------------------------------------------------------------ ------------------- >G_aculeatus_ENSGACP00000027283 --------------------------------KN-NPFLMGLCRNGP-PPDL-QYDNSSE LFRISTFARFP-ASGVT-ERSLARAGWFYIG---------------VGDRVQCFRCNVTA EGWQAGDCPTEKHRQLSPTCSFIQSLPSTTNLLSSSHSAFSPLRIAPAV----------- ---PA-VSQGEEPVGY-LNMGFSAPPPSSPLSSRGVEDMSHQR-PTCHNPSKRKE----- ---QDRLDSFHP-WTL---S---IITPSELAK--------AGFY---YL----------G QGDRVACF---------------------------------------------------- ----------SCGGQLSNWEPGDRAVS---EHQRHYPNCRFLSS---------------- -------GAAAL------------------------------------------------ ---------------------------NNVS---NPAMQQSDERLLTF-V---NWPA-RI PVRPDQLA-----KAGFYYV-GRNDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWVEHAKWFP --RC---EYLIQE-KGQE-------------FVHQIQAR----------FPRLFEQ--LL ANGDNNSREFIDPP---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------VV HLGPGEERSEDAVMMNTPVI---KSALEMGFERGLVKQTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SKILTSGENYRTVQEL------------ ----VLDLLS--AEDQKREE-EREMVAE---AMAS--DGFTFVKRHQ---ATLIQRLKS- VEPVLEHLREQNVLSPDEYGGLKAQTSAQLQNGKLIELVLTKG----------------- ------------------------------------------------------------ --------------------------------------------------------NAAA EVFRNWIQKNDVHLLRDLMAQSNEA-----ASPSQDL--SD--LPMEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---KEVNIVFIPCGHLVVCKECAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRGLVKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >C_intestinalis_ENSCINP00000009820 -------------------------------------------------------DAAME SYRLSTFMKYPQDTPVN-PRHLAAAGFHYTG---------------YKDRVKCFCCGLCV ENWVSGDE-IKSKKWHRNNCELVNGNGSGNQPIAGDDFKSTISPLCE------------- ---CKALSMVLKTPKI-QGCRKFSMPLSFFVRIELATIASPYHEQLVRSLDLRKE----- ---SDRSKTYEN-WPA---QN-RTVYASDLAR--------SGFF---YL----------G NLDRVQCF---------------------------------------------------- ----------SCGGVLRNWNYGDNITA---EHTRHFPHCSLFYAQ--------------- -------------------LELSEMFPC-------------------------------- ---------------------------QYPV---NPHMRNQDMRLATFDQ---RWQQRAL QAKPAQIS-----KAGFFFL-GDRDRVKCW------------------------------ ------------YCNG------------------------GLQNWDPNDEPWTEHAKWFP --TC---EFLIRS-KGPD-------------FVHAMVSK----------YPNLPRP--IL RGPFDVPPSIRR------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------NSESTAPPPIM DHKMAEMKTKVKKHMESEEA---KSVLEMGFGRKELEKVIK------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------KKLKKDGKMFKSVVSI------------ ----IDAM------NDGTDS-SDDEMEA---DEPQTQTPMSISDLGRKGLFPCIGCILK- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------IV IRFKNHINTKYKTNYHKVHTPQIKIKYYP----------TDLSPSMLARVAELE------ ----------EERKCKVCLD---------------------------------------- ---KMADIVFIPCGHLCTCIECASALNKC------------------------------- ------------------------------------------------------------ -----------------------------PICRKRIEK---SIRTYLN------------ ------------------------------------------------------------ ------------------- >A_gambiae_AGAP012677-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M PQTPERMA-----DAGFFYT-GKSDVVACF------------------------------ ------------YCGG------------------------NLRDWLAEDDPWVEHVRNFS --EC---PYVKLV-KTPE-------------FIAECRGE----------KVTNSAL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TAGPEHSG-HGN------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VSKDKEQDEVS------ ----------DEKCCKICFT---------------------------------------- ---RPFDTVFMPCGHVVACGRCAATTTKC------------------------------- ------------------------------------------------------------ -----------------------------PMCNEPYTS---VQRIYFS------------ ------------------------------------------------------------ ------------------- >P_troglodytes_ENSPTRP00000023641 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LGLDTCR---------AW DHVDGQILGQLRPLTEEEEEEGAGATLS-------------------------------- ---------------------------RGPA---FPGMGSEELRLASF-Y---DWPL-TA EVPPELLA-----AAGFFHT-GHQDKVRCF------------------------------ ------------FCHG------------------------GLQSWKRGDDPWTEHAKWFP --SC---QFLLRS-KGRD-------------FVHSVQET----------HSQLLGS--WD PWEEPE------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DA APVAPSVPASG------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----YPELPT--PRREVQSE-SAQEPGG---VSPAQAQRAWWVLEPP------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GA--GDVEAQLRRLQ------ ----------EERTCKVCLD---------------------------------------- ---HAVSIVFVPCGHL-VCAECAPGLQLC------------------------------- ------------------------------------------------------------ -----------------------------PICRAPVRS---HVRTFLS------------ ------------------------------------------------------------ ------------------- >G_gorilla_ENSGGOP00000008152 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------M----------G PKDSAKCL---------------------------------------------------- ----------HRGPQPSHWAAGDGPTQ---ERGGPRSLGSPVLGLDTCR---------AW DHVDGQILGQLRPLTEEEEEEGAGATLS-------------------------------- ---------------------------RGPA---FPGMGSEELRLASF-Y---DWPL-TA EVPPELLA-----AAGFFHT-GHQDKVRCF------------------------------ ------------FCYG------------------------GLQSWKRGDDPWTEHAKWFP --SC---QFLLRS-KGRD-------------FVHSVQET----------HSQLLGS--WD PWEEPE------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DA APVAPSVPASG------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----YPELPT--PRREVQSE-SAQEPGG---VSPAQAQRAWWVLEPP------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GA--RDVEEQLRRLQ------ ----------EERTCKVCLD---------------------------------------- ---RAVSIVFVPCGHL-VCAECAPSLQLC------------------------------- ------------------------------------------------------------ -----------------------------PICRAPVRS---RVRTFLS------------ ------------------------------------------------------------ ------------------- >H_sapiens_ENSP00000217169 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------M----------G PKDSAKCL---------------------------------------------------- ----------HRGPQPSHWAAGDGPTQ---ERCGPRSLGSPVLGLDTCR---------AW DHVDGQILGQLRPLTEEEEEEGAGATLS-------------------------------- ---------------------------RGPA---FPGMGSEELRLASF-Y---DWPL-TA EVPPELLA-----AAGFFHT-GHQDKVRCF------------------------------ ------------FCYG------------------------GLQSWKRGDDPWTEHAKWFP --SC---QFLLRS-KGRD-------------FVHSVQET----------HSQLLGS--WD PWEEPE------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DA APVAPSVPASG------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----YPELPT--PRREVQSE-SAQEPGG---VSPAEAQRAWWVLEPP------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GA--RDVEAQLRRLQ------ ----------EERTCKVCLD---------------------------------------- ---RAVSIVFVPCGHL-VCAECAPGLQLC------------------------------- ------------------------------------------------------------ -----------------------------PICRAPVRS---RVRTFLS------------ ------------------------------------------------------------ ------------------- >H_sapiens_ENSP00000321377 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MTGYEARLITF-G---TW---MY SVNKEQLA-----RAGFYAI-GQEDKVQCF------------------------------ ------------HCGG------------------------GLANWKPKEDPWEQHAKWYP --GC---KYLLEE-KGHE-------------YINNIHLT----------RS-LEGA--LV QTTKKT------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---PSLTKRISDTIFPNPML---QEAIRMGFDFKDVKKIME------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------ERIQTSGSNYKTLEVL------------ ----VADLVS--AQKDTTEN-ELNQTSL---QRE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ISPEEPLRRLQ------ ----------EEKLCKICMD---------------------------------------- ---RHIAVVFIPCGHLVTCKQCAEAVDRC------------------------------- ------------------------------------------------------------ -----------------------------PMCSAVIDF---KQRVFMS------------ ------------------------------------------------------------ ------------------- >M_mulatta_ENSMMUP00000012096 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------M----------G PEDSAKCP---------------------------------------------------- ----------RHGPQLCRWAAGDGPAR---ERCGPRSLGSPALGLDSCR---------AW DHVDGQILGQLRPLAEEEEEEGAGAMSP-------------------------------- ---------------------------RGPA---FPGMGSEELRLASF-Y---DWPL-TA GVPPELLA-----AAGFFHT-GQQDKVRCF------------------------------ ------------FCYG------------------------GLQSWKRGDDPWTEHAKWFP --SC---QFLLRS-KGRD-------------FVHSVQET----------HSQLLGS--WD PWEEPE------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DA APVAPSVPAPG------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----DPELPT--PRREVQSE-SAQEPGG---ASPAQAQSGWWVLEPP------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GA--RDVEEQLRRLQ------ ----------EERTCKVCLD---------------------------------------- ---RAVSIVFVPCGHL-VCAECAPSLQLC------------------------------- ------------------------------------------------------------ -----------------------------PICRAPVRS---RVRTFLS------------ ------------------------------------------------------------ ------------------- >C_intestinalis_ENSCINP00000010449 ------------------------------------------------------------ ----------------------------------------------MQARMMDIRCDGLR VVHNDGRLVPSATNSERE------------------------------------------ --------------------------------------------LYTRPGDPYYE----- ---SYRLATFTN-YPN---Q---NINVRQVAR--------AGFY---FI----------S YQDQVKCF---------------------------------------------------- ----------SCGQICEDLQQYDDMSL----PQWHLPDCEHLHSLQPNRNNHANTPVQSG LSRPNENATFRSLPTRRPAHSNVHSSSSLPRQPTTITINQPRIRSTFTIHEHSNI----- ---DLFPC-------------------NRPE---SPHMRSVEQRLQTFTRS--NWPAHRV RASILDIS-----RAGLFYL-GNSDRTKCW------------------------------ ------------YCNG------------------------GLQNWEPNDDPWYEHAKWFP --EC---EFLLQQ-KGIE-------------YVYRVSSQ----------FPNLQRP--VI VRSQPQPSVTIHIN---------------------------------------------- ------------------------------------------------------------ ---------RPGRTTMPTASTTHTTSSTTRISAPRSTVVSGPQFLPPMIPGPSINIIDPR EQPRSREEELNRYITTSPYI---AVARGMGFDDEAIRSTLR------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------RQHEQSQRFFSSAEEL------------ ----VDALLN----QSNITS-APQIPSS---STAGATGGP-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ITPLEELRQLE------ ----------QSRMCKVCHR---------------------------------------- ---NQANMVLLPCGHVACCTTCGNDVTNC------------------------------- ------------------------------------------------------------ -----------------------------PVCLADITD---RVRSYIG------------ ------------------------------------------------------------ ------------------- >A_carolinensis_ENSACAP00000005440 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------QPE---YPDLAMERDRLRTY-D---SWPS-DA QVSPEELA-----GAGFFYT-GDRDYVLCF------------------------------ ------------YCDG------------------------ALRNWERGDDPWMEHARWFP --RC---EFLLQS-RGRD-------------FINSIQDS----------YFSTLVS--KV VLKDPF------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PK TGMTEKQNPCG------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----NVEIIP--CSREVETE-QPNQPDS---T---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LSTEEKLRQLQ------ ----------EERMCKVCMD---------------------------------------- ---KDVSIVLVPCGHLVVCSECAPNL---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------- >P_pygmaeus_ENSPPYP00000012543 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------M----------G PKDSAKCL---------------------------------------------------- ----------HCGPQPSHWAAGDGPAQ---EHCGPRSLGSPVLGLDTCR---------AW DHVDGQILGQLRPLAEEEEEEGAGATLS-------------------------------- ---------------------------RGPA---FPGMGSEELRLASF-Y---DWPL-TA EVPPELLA-----AAGFFHT-GQQDKVRCF------------------------------ ------------FCYG------------------------GLQSWKRGDDPWTEHAKWFP --SC---QFLLRS-KGRD-------------FVHSVQET----------HSLLLGS--WD PWEEPE------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DA APAAPSVPASG------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----DPELPT--HRREVQSE-SAQE---------------------P------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GA--RDVEEQLRRLQ------ ----------EERRCKVCLD---------------------------------------- ---RAVSIVFVPCGHL-VCAECAPSLQLC------------------------------- ------------------------------------------------------------ -----------------------------PICRAPVRS---RVRTFLS------------ ------------------------------------------------------------ ------------------- >E_caballus_ENSECAP00000017749 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------SM----------G PEDKAKCW---------------------------------------------------- ----------CRGLELSHQAAGGSPMQ---GHHRPHCLALSWGGR--------------- DHVDGQILGQLHPLAEEEEEGAGAVAAPS------------------------------- ---------------------------TRPA---FPRMGSEELRLASF-C---HWPL-TA VVRPELLA-----AAGFFHT-GWQDKVRCF------------------------------ ------------FCHG------------------------GLQSWERGDDPWTEHAKWFP --RC---EFLLQT-KGRD-------------FVCRVQES----------CCHQLSS--WD QLEEPE------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DA APSVPSTPVHR------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----GPDPPM--PRREAQS--GARE---------------------P------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GA--QNVEEQLQRLR------ ----------EERTCKVCLD---------------------------------------- ---RAVSVVFVPCGHL-VCAECAPNLQLC------------------------------- ------------------------------------------------------------ -----------------------------PICRAPIDS---CVRTFLS------------ ------------------------------------------------------------ ------------------- >T_nigroviridis_ENSTNIP00000018867 -------------------------------------MEDQRHDNSNLETDS-AEDFSLI KSRLESFRGSSLVQRVP-AERLARAGFYLVG---------------PSDRVRCFSCQKTV ENWSREDRPVERHKEVSPVCQFLSCIYGTRPHQLIDASLANNSAYNE------------- ---------------------------------EAVVDES----IYPVAPHMKSE----- ---KSRLQTFSS-WPS---AV--PVRPQDLAQ--------AGLY---YL----------G QNDQVQCF---------------------------------------------------- ----------CCGGILANWDAGDSAWG---EHNKHFPSCFFILGHDVGN----------- ----------IPLQGSGEEEKRVVPPA--------------------------------- ---------------------------GAGA---GVHMGTFEERLRSF-A---NV---QH PVNTERLA-----RAGFYSK-G-TDAVLCF------------------------------ ------------SCNG------------------------GLKGWRPEEDPWEEHARHYP --GC---RFLLTE-KGQE-------------FVNSIQLR----------VSGRNTA---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------VSQAVQDIQVF---KKIATVHFRVQVIRMDFQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------QQQ-WVHTHTK---VHTDSSRQFFFKCETAAGQQNNRIFDIGV CPSCPPE----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------DDPKKLLQKLQ------ ----------CEKMCKICLA---------------------------------------- ---KDICIVFIPCGHLIACEECSESLVSC------------------------------- ------------------------------------------------------------ -----------------------------PVCCGGITQ---KVKTFLTYPAKQ------- ------------------------------------------------------------ ------------------- >C_familiaris_ENSCAFP00000018803 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------M----------G PEDRAKCW---------------------------------------------------- ----------CRGPELGRGRLSPCGHT---EGRDGRC-ARCWGGR--------------- DRVDGQILGQLRPLAEEEEAGEPRAGP--------------------------------- ---------------------------PRPA---FPGMGSEQLRLASF-S---AWPL-TA VVQPELLA-----AAGFFHT-GQQDKVRCF------------------------------ ------------FCYG------------------------GLQSWEQGDDPWTEHAKWFP --RC---EFLLQT-KGRD-------------FVCSVQEA----------CCHLLGS--WD PSEEPE------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DT APATPSAPVHM------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SPELPT--PRREVQSE-GAREPGK---GVEPRPRGCCWVLEPP------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GA--RDAEEQLQRLR------ ----------EERVCKVCLD---------------------------------------- ---RTVCTVFVPCGHL-VCAECAPALQLC------------------------------- ------------------------------------------------------------ -----------------------------PVCRAPIRS---CVRTFLP------------ ------------------------------------------------------------ ------------------- >D_rerio_ENSDARP00000075338 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GMRSE----- ---EERLQTFHN-WPS---DA--AVSPEELAR--------AGFH---YL----------G YGDTVQCF---------------------------------------------------- ----------CCEGILRHWVDGDTPRG---EHERHFPTCGLMRGRDVGN-----VPRGSS DSVD-------------------------------------------------------- ----------------------------------DSEMETEDNRRSTF-H---NWPT-GA AVQPDTLA-----RAGFFYT-GHGDNVKCF------------------------------ ------------FCDG------------------------GLRNWEPGDDPWQEHAKWFP --QC---EYLLQS-RGQE-------------YVRNVQQS----------FFNMNGR--GV RKNDAPQQQFMLSQPTFH------------------------------------------ ------------------------------------------------------------ ----PGT---------------------------------------------------EV LGGQRSVAAP----MLSPVV---QAVLQMGFQHSLVESLVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SRFLLTGAHYTSVSDL------------ ----VTDVLQ--AEEEEERQ-TGDTRSG---VAHPLFANTLLYQNKIKLYYVCLKKKINM LKHFKSNLLNNYINKINNNNYSHNNFFYFTKKSLKMIFIIIKM----------------- ------------------------------------------------------------ --------------------------------------------------------QLTR IIYFHWFNINDVCLLRDCGDAENTK-----NDKNKNAVRSD--LSPEEQLRQLQ------ ----------EERTCKVCMD---------------------------------------- ---KLVSMVFIPCGHLVVCSDCAASLRHC------------------------------- ------------------------------------------------------------ -----------------------------PICRAVIRG---SVRAFMS------------ ------------------------------------------------------------ ------------------- >P_troglodytes_ENSPTRP00000019640 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MTGYEARLITF-G---TW---MY FVNKEQLA-----RAGFYAI-GQEDKVQCF------------------------------ ------------HCGG------------------------GLANWKPKEDPWEQHAKWYP --GC---KYLLEE-KGHE-------------YINNIHLT----------RS-LEGA--LV QTTKKT------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---PSLTKRINDTIFPNPML---QEAIRMGFDFKDVKKIME------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------ERIQTSGSNYKTLEVL------------ ----VADLVS--AQKDTTEN-ESNQTSL---QRE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ISPEEPLRRLQ------ ----------DEKLCKICMD---------------------------------------- ---RHIAVVFIPCGHLVTCKQCAEAVDRC------------------------------- ------------------------------------------------------------ -----------------------------PMCSAVIDF---KQRVFMS------------ ------------------------------------------------------------ ------------------- >G_gorilla_ENSGGOP00000008442 --------------------------MTFNSFEGSKTCVPADINK--------EEEFVEE FNRLKTFANFPSGSPVS-ASTLARAGFLYTG---------------EGDTVRCFSCHAAV DRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKV------------- ------ENYLGSRNHF-ALDRPSETHADYLLRTGQVVDISDT--IYPRNPAMYSE----- ---EARLKSFQN-WPD---YA--HLTPRELAS--------AGLY---YT----------G IGDQVQCF---------------------------------------------------- ----------CCGGKLKNWEPCDRAWS---EHRRHFPNCFFVLGRNL-N----------- ----------IRSESDAVSSDRNFPNST-------------------------------- ---------------------------NLPR---NPSMADYEARIFTF-G---TW---IY SVNKEQLA-----RAGFYAL-GEGXKVKCF------------------------------ ------------HCGG------------------------GLTDWKPXEDPWEQHAKWYP --GC---KYLLEQ-KGQE-------------YINNIHLT----------HS-LEEC--L- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------- >O_cuniculus_ENSOCUP00000008710 ----------------------------MNIVEN-SIFLANLMKSAN-TFEL-KYDFSCE LYRMSTYSTFPAGVPVS-ERSLARAGFYYTG---------------VNDKVKCFCCGLML DNWKQGDKPIEKHRKLYPSCSFVQSLNSVNNWEANSRSTFPSSVTNS------------- --THS-FLPSWEHSGY-YSGSYSS-LPSNPVNSRANQDFSAFR-VSPYHSAMSTE----- ---KARLLTFQS-WPL---T---FLSPMDLAK--------AGFY---YV----------G PGDRVACF---------------------------------------------------- ----------ACGGKLSNWEPKDDAMS---EHLRHFPNCPFVENQLQDA----------- ----------SR------------------------------------------------ ---------------------------YTIS---NLSMQTHAARFKTF-F---NWPS-SL LVHPEQLA-----SAGFYYV-GHSDDVKCF------------------------------ ------------CCDG------------------------GLRCWELGDDPWVEHAKWFP --RC---EYLIRI-KGQE-------------FISXXXXX----------XXXXXXX--LL STSDTPEDENAEPP---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------XX XXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXX------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------XXXXXXXXXXXXXXXX------------ ----XXXXXX--XXXXXXXX-XXXXXXX---XXXX--XDLSLIRRNR---MALFQHLTC- VIPILDSLLTSGVINEQEHAVIKQKTQTSLQARELIDIILVKG----------------- ------------------------------------------------------------ --------------------------------------------------------NYPA TVFQDCLPGFDPVFSMYLF----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------- >P_troglodytes_ENSPTRP00000048273 MATQQKASDERISQFDHNLLPELSALLGLDAGQLAKELEEKEQKERAKMQKGYNSQMRSE AKRLKTFVTYEPYSSWI-PQEMAASGFYFTG---------------VKSGIQCFCCSLIL FGAGLTRLPIEDHKRFHPDCGFLLNKDVGNIAKYDIRVKNLKSRL-R------------- ----------------------------------------------GGKMRYQEE----- ---EARLASFRN-WPF---YV-QGISPCVLSE--------AGFV---FT----------G KQDTVQCF---------------------------------------------------- ----------SCGGCLGNWEEGDDPWK---EHAKWFPKCEFLRSKKSSEEITQYIQSYKG FVDITGEHFVNSWVHRELPMAS-------------------------------------- ---------------------------AYC---NDSIFAYEELRLDSF-K---DWPR-ES AVGVAALA-----KAGLFYT-GIKDIVQCF------------------------------ ------------SCGG------------------------CLEKWQEGDDPLDDHTRWFP --NC---PFLQNM-KSSV-------------EVTPDLQS----------RGEPCEL--LE TTSESNLEDSIAVDHIVP------------------------------------------ --EMAQGEARWFQEAKNLNEQLRAAYTSASFRHMSLLDISSDLATD-HLLGCDLSIASKH ISKPVQEPLVLPEVFANLNSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYL SLSSTRPDEGLASIICDQLLEKEGSVTEMCMRNIIQQLKNQVLFLLDDYKEICSIPQVIG KLIQKNHLSRTCLLIAVRTDRARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRK FMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDP-SFDDVAVFKSYMERLSLRNKATAE ILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRFL SPAFQEFLAGMRLIELLDSDRQEHQDLGLYHLKQINSPMMTVSAYNNFLNYVSSLPSTKA GPKIVSHLLHLVDNKESLEN-ISENDDY---LKHQPEISL-QMQLLRGLWQICPQAYFSM VSEHLLVLALKIAYQSNTVAACSPFVLQFLQGRTLTLGVLNLQ------YFFDHPESLSL LRSIHFSIRGNKTSPRAHFSVLETCFDKSQVPTIDQDYASAFEPMNEWERNLAEKEDNVK SYMDMQRRASPDLSTGYWKLSPKQYKIPCLEVNVNDIDVVGQDMLEILMTVFSASQRIEL HLNHSRGFIESIRPALELSKASVTKCSISKLELSAAEQELLLTLPSLESLEVSGTIQSQD QIFPNLDKFLCLKELSVDLEGNINVFSVIPEEFPNFHHMEKLLI-QISAEYDPSKLVKLI QNSPNLHVFHLKCNFFSDFESLMTMLVSCKKLTEIKFLDSFFQAVPFVASLPNFISLKIL NLEGQQFPDEETSEKFAYILGSLSNLEELILPTGDGIYRVAKLIIQQCQQLHCLRVLSFF KTLNDDSVVEIAKVAIS-GGFQKLENLKLSINHKITEE---GYRNFFQALDNMPNLKELD ISRHFTECIKAQATTVKSLSQCVLRLPRLIRLNMLSWLLDADDIALLNVMKERHPQSKYL TILQKWILPFSPIIQK--- >C_familiaris_ENSCAFP00000022282 ----------------------------MNIVQN-SIFLSNLLRSSP-VFEL-KYDHSCE LYRMSTYSTFPAGVPVS-ERSLARAGFYYTG---------------AKDRVRCFCCGLML DNWKAGDSPTGKHRNLYPSCSFIQNLSAVSTVGAASQPPAPLSEARS------------- --THA-QSPGLERSSY-FSASYSS-FPVDPVDFRPSPAMSPWR-AGPSCVTMKSE----- ---EDRLCTFQG-WPL---A---FPLPSALAR--------AGFY---YV----------G PGDRVACF---------------------------------------------------- ----------ACGGKLSNWEPDDDALS---EHLRHFPDCPFVEGQLQAT----------- ----------VR------------------------------------------------ ---------------------------YTAS---NLSMQTLAARSRTF-C---NWPP-RA PVHPEQLA-----SAGFYYM-GHSDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWVEHAKWFP --RC---EYLIRI-KGQE-------------FISQIQAS----------YPHLLEQ--LL STSDNTEDENTESP---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------IV HFGPGEYHSEDAVMMNTPVV---MAALEMGFSRSLVRQTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SKILSTGENYRTVNEI------------ ----VSDLLH--VEDEIREE-EKERAAE---NRES--DDVSLIRKNK---MVLFQHLTY- VLPILDSLLMAGVLNEQEHSSIKQKARTSLQARELIDTVLVKG----------------- ------------------------------------------------------------ --------------------------------------------------------SSAV TIFKNSLQEIDPMLYKRFFVQQDRK-----YIPTEDI--SD--LPVEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---KEVSIVFIPCGHLVVCRDCAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRGTVRG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >B_taurus_ENSBTAP00000004317 MATQEKAPEERISQFDYALLPEMSAFLGVNALQFVKEIEEKEHRDREKMQKGFNSQMRSE AKRLKTFVTYNTFRSWT-SQEMAEAGFYLTG---------------TKSGIQCFCCSLIL FGTSLQNTPMEHHKKFHPDCEFLLGKDVGNIAKYDVRVQKPENTLRR------------- ----------------------------------------------DDKARYQEE----- ---KARLESFKN-WPF---YA-QGTSPRELSA--------AGFV---FT----------G KHDTVQCF---------------------------------------------------- ----------SCGGCLGNWEDDDDPWK---EHAKWFPKCEFLQSKKSLEEITQYIQSYKG FVDVTGEHFLNSWVKRDLSVAS-------------------------------------- ---------------------------VCCNGSNSSSFVNEELLLQSF-K---SWHP-SY PVGAAALA-----KAGFFYT-GKSDIVQCY------------------------------ ------------SCGG------------------------YLHDWKEGDDPLEEHAKFFP --NC---QFLQSV-KSSA-------------EAIPDLQS----------HDELSEL--TE TTNEGNLEESTAVSSIVP------------------------------------------ --EVAQGEAQWFQEAESLSEHLRKVYTSAPFCHMSLLEISSCLATD-QWLDCDLSFALKH ITNPVQEPVVLPEVFANLNSVMCVEGEAGSGKTILLKKIAHLWASGRCPLLNRFRLVFCL SLGSTRPEQGLASVIRDQLLETKLSVTEMGLRNIIQQLKNQVLFLLDDYKEMCSVPQVIA RMIQKKHLSRTCLVITVRTNRAKNIRRYLDTIIEIKAFPFYNTISILRKLFPGDLTRLRK LMVDFGMNQTWQGIQKTPLFVAAVRASWLQNRFHR-SFDSVAVFESYMECLFLKHKTEAD LLKATVSSCGDLALKGFFSSCFEFSDEDLIEAGIGEEEDLAMYLMSKFTAQRLRPVYQFL NPAFQEFLAGMRLTELLDSDRQEDQDLGLHYLKRINSTLMVIYPYANFLNCVSRHPSTKA GPKIVSHLLLLVDNKETLEN-ISENDDY---LKHHPEISE-VMQFFRLIWQLSPQNYLSL ASKHLLALAIRIAYQSNTVAACSPFILQFLRGRTLCLDVLKLQ------YFFDHPESLLL LRSIQVSINGNRLF-KTD-TPLERIFDKSQAPTIEQDYASAFELESEWKQSLDEKHEIIQ NFQNMRLNAPPAINTGYWNLPSKQYKIPLLEVHVTNTHAVDQEMLRFLTEVFSAAQHIEL HLNHSRGFIENIRPALEQFRASFTKCCISQCELSAIEQELLLTLTSLESLEVSETTHPQD QLFLSLDKFLCLKELSVNLQ--QDVFSAISEEFLNLHHMEKLLI-QISSKCSPSKLVRLV QNSPNLQVFHLECNSFSDFESLVTALASRKKLEEIKFSGQFFQANPFVIVLPNFTSLKIL KLGIQYIPDKETAEKFAYALGSLNNLEELILPTGDGIHQMAKLIIQQCQHLQCLQVLQFF KTLDDDSVVEIAKVAIN-GGFQKLKHLDFSMNHKITEE---GYRNFFQTLDNLPSLQELT ISRHFKECIKVQAATVKSLSQCVLRLPSLLRLNMLSWLLDAEDITLLTATIKKHPQSKHF ILSWKWILPFSPIIQEPIS >O_latipes_ENSORLP00000010149 ------------------------------------------------------------ ---------------VS-PLQLAEAGFLFTG---------------VSDRVRCFSCQKTV ENWSQEDQPVDRHIQVSPSCTFLRCTHFNRFKSNPHMPLSNGGLHDG------------- ----------------------TEGYIDYQLRTRAIVDET----PYPRNRNMKSE----- ---EARLETFSS-WPR---SA--PVRPRDLAQ--------AGLF---YL----------G KEDKVECF---------------------------------------------------- ----------SCGGKLSGWKPGDTPWN---EHEKHFSHCFYILGHDVGN----------- ----------VPLERDGGENEET-GSRN-------------------------------- ---------------------------QHRT---PVNLENLDERLGTF-A---RV---QH PIDHELLA-----KAGFYSKVGEGDEVICF------------------------------ ------------RCGG------------------------GLKDWDPEDNPWEEHAKYYP --GC---SFLLSE-KGQE-------------FVNTIQLQ----------EPKYSQQ--VR HIISP------------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------HL RNLFLKLLHFPSFCRNTKKV---YFVLCLAYSLLKSWWGST------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------FLMSSDKRIYKKLQNI------------ ----KMDFLK--RRKLAEPF-EKENLSQ---GSATFSTCR----------ANQLWIFHRN KTVIKINLFEI--VRTFNRGLHDFLSSLYLSARNLMKNILVFF----------------- ------------------------------------------------------------ --------------------------------------------------------NMRA TKSFVGVKLKVKKHYLLQFYINYIR-----TGLTI--------ENPLEELEKLR------ ----------QEKRCKICLD---------------------------------------- ---ENACIVFIPCGHLASCKACSNKLNQC------------------------------- ------------------------------------------------------------ -----------------------------PICCAAIAQ---KIRTFIA------------ ------------------------------------------------------------ ------------------- >A_carolinensis_ENSACAP00000011315 -----------------------------------------------------------E LSRQQTFASFPSDCPVS-SAALAQAGFFYTG---------------ERDQVKCFSCHTMV EGWQEGDSAIERHRTIFPECRFINDIDIGRNNTYSLLNCQHASENGS------------- --------ASTSQQQP-SLDESSDLDADYLLRTGQVVDLSGS--LYPRNPAMCSE----- ---EARLRTFHN-WPP---YA--PVTPQDLAH--------AGLY---YT----------G IGDQVECF---------------------------------------------------- ----------CCGGKLKNWEPSDQAWS---EHRRHFPRCFFVLGHDLNR----------- ------------------------SNNV-------------------------------- ---------------------------VLPQ---NPCMADYETRLKTF-V---AW---HY LVSKEQLA-----RAGFYSI-GNGDSVACF------------------------------ ------------HCGG------------------------GLQEWKAYEDAWEQHAKWFP --GC---KYVLEE-KGQD-------------FVNRV------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------- >M_musculus_ENSMUSP00000058611 MAEHGESSEDRISEIDYEFLPELSALLGVDAFQVAKSQEEEEHKERMKMKKGFNSQMRSE AKRLKTFETYDTFRSWT-PQEMAAAGFYHTG---------------VRLGVQCFCCSLIL FGNSLRKLPIERHKKLRPECEFLQGKDVGNIGKYDIRVKRPEKML-R------------- ----------------------------------------------GGKARYHEE----- ---EARLESFED-WPF---YA-HGTSPRVLSA--------AGFV---FT----------G KRDTVQCF---------------------------------------------------- ----------SCGGSLGNWEEGDDPWK---EHAKWFPKCEFLQSKKSSEEIAQYIQSYEG FVHVTGEHFVKSWVRRELPMVS-------------------------------------- ---------------------------AYC---NDSVFANEELRMDMF-K---DWPQ-ES PVGVEALV-----RAGFFYT-GKKDIVRCF------------------------------ ------------SCGG------------------------CLEKWAEGDDPMEDHIKFFP --EC---VFLQTL-KSSA-------------EVIPTLQS----------QYALPEA--TE TTRESNHGDAAAVHSTVV------------------------------------------ --DLGRSEAQWFQEARSLSEQLRDNYTKATFRHMNLPEVCSSLGTD-HLLSCDVSIISKH ISQPVQEALTIPEVFSNLNSVMCVEGETGSGKTTFLKRIAFLWASGCCPLLYRFQLVFYL SLSSITPDQGLANIICAQLLGAGGCISEVCLSSSIQQLQHQVLFLLDDYSGLASLPQALH TLITKNYLSRTCLLIAVHTNRVRDIRLYLGTSLEIQEFPFYNTVSVLRKFFSHDIICVEK LIIYFIDNKDLQGVYKTPLFVAAVCTDWIQNASAQDKFQDVTLFQSYMQYLSLKYKATAE PLQATVSSCGQLALTGLFSSCFEFNSDDLAEAGVDEDEKLTTLLMSKFTAQRLRPVYRFL GPLFQEFLAAVRLTELLSSDRQEDQDLGLYYLRQIDSPLKAINSFNIFLYYVSSHSSSKA APTVVSHLLQLVDEKESLEN-MSENEDY---MKLHPQTFL-WFQFVRGLWLVSPESSSSF VSEHLLRLALIFAYESNTVAECSPFILQFLRGKTLALRVLNLQ------YFRDHPESLLL LRSLKVSINGNKMSSYVDYS-FKTYFENLQPPAIDEEYTSAFEHISEWRRNFAQDEEIIK NYENIRPRALPDISEGYWKLSPKPCKIPKLEVQVNNTDAADQALLQVLMEVFSASQSIEF RLFNSSGFLESICPALELSKASVTKCSMSRLELSRAEQELLLTLPALQSLEVSETNQLPE QLFHNLHKFLGLKELCVRLDGKPNVLSVLPREFPNLLHMEKLSI-QTSTESDLSKLVKFI QNFPNLHVFHLKCDFLSNCESLMAVLASCKKLREIEFSGRCFEAMTFVNILPNFVSLKIL NLKDQQFPDKETSEKFAQALGSLRNLEELLVPTGDGIHQVAKLIVRQCLQLPCLRVLTFH DILDDDSVIEIARAATS-GGFQKLENLDISMNHKITEE---GYRNFFQALDNLPNLQELN ICRNIPGRIQVQATTVKALGQCVSRLPSLIRLHMLSWLLDEEDMKVINDVKERHPQSKRL IIFWKLIVPFSPVILE--- >A_carolinensis_ENSACAP00000009897 ------------------------------------------------------------ -------------STWA-PLEMAAAGFYHTG---------------TKTAIQCFCCGLVL LARSIKRSPYVEHKKYWSQCAFILGKEVGNIPKYEIRVLYPRRR---------------- ----------------------------------------------YSGVTYKHL----- ---ESRLQSFAD-WPS---YA-REAQPDLLAK--------AGFF---FT----------G IKDTVQCF---------------------------------------------------- ----------ACSGCLGNWEDGDDPWK---EHAKWFPECEFLQKEKTRDEIKEYIQNYCA FVGLTVSFFAFTLLIYLVPKGD-------------------------------------- ---------------------------LELA---INIYEDEGCRLDSF-Q---TWPA-EA RVDATSLA-----KAGFFYT-GKMDIVQCF------------------------------ ------------SCAG------------------------CLAEWKGDDDPWEGHAKAFP QEEC---DFMQNLAKITS-------------MPFQDMKL-------------------CQ HSSSFHHISHIFLLSLLT------------------------------------------ --------DVAFEEHKLLQEQLRRAYDDIHFRKMFPFGDSAHFAIDLKTLFGDLAIVSKN ISNLPLQQLTLPEVLENFQFITVVEGEAGSGKTALLRKIAILWASGCCPILSRYKLVFYL SLNSQNRDLSLVDIICNEVVGLRGVLTQEFLETLCKHLKNEILFLLDDYDEMNAVPYDIE DLIQKNYLNKHCLVIAVRTNRIGKIRQYAKTILGITDFPMTSTFYLLRKLFSHNTALVED FFIQLRVEEAMHSMFKTPLFVVALGTYWTQNPNGS-KFLDLVILKAYMLYTSLKYPQACD RMKATVSACGELALRGLFTSLFEFSEEDLSEVGVSGDDALWFGLLSKFTAQRLWPIYKFF HLSFQEYFAGLRMNELLSSDVQEDVDRGLQYLQQINTFVKISGRYQYILRYACVE-ASKA VPQIVTHLLSLPSCEKSFES-QIKNDLY---LQQTPELKLRQQELLSVTLTLFPEVYLST FSDFVLELVTELAYQSNMTPACAPIISQFLAGKEFSLDHFSSKGGFIRRFFLDYPDTLFL PSRFVMKTIGKEE--NLDMSVEETVYSNLGVPVVDQEYASGFRLFSDVSKQIKEDEDNIN KFRTYFPRRFPNSRIVPFLCKRGQEKIPHLQFSAKCINAFQTHDLENLAVLFSVFSHIDL KLQNCKGLLENIKPAIEQNLEYFKVCSIHNTALNLVEENLLLSMSSLESLEITGKASIPE SLFLNLDKYTFLKELSVDLPNCQNLFDIIPEGFKNLHDMEKFIICNIQFGSSSPRLAEFI RNFKKLSVFHLKHCSFSDLGSLMDAMSSCKMLTELEIIELPFTDEDHSAALPNFAALKIL NLNGLNFTSKEIGIALGEALAPLENLEELSLPVGNGMSHAAKLIIQQCSHFPNLRKLEFN QYLSGEGLLEIAKVATD-GGFQKLEVLTLLVNHSITEE---FWRRFFESLPQLPKLHDAN FGRIFTHPIKCQAATVKSFVQCVSRQQNLKVINMTGWLFDEKDLQMFDIMKEQHPQSKNL SLFWKWMLPVSPIINK--- >O_cuniculus_ENSOCUP00000011948 ---------HKTTSPRVVPG-TV--YRTQNMMED-STILXXXXXXX--XXXX-XXXXXXX XXXXXXXXXSPNGVPVS-ERSLARAGFYYTR---------------VNDKVKCFCCGLML DNWKQGDNPIEKHKQLYPSCSFIQNLVS-ASLDSTIKNT-SPVRSSF------------- --AHS-LSPTVEPGGS-FSGSYSS-LSANPLNSRTVEDFSPLR-TNPYSYSMSSE----- ---EARFLTYHM-WPL---S---FLSPSELAR--------AGFY---YI----------G PGDRVACF---------------------------------------------------- ----------ACGGKLSNWEPKDDAMS---EHRRHFPKCPFLENSL-ET----------- ----------LR------------------------------------------------ ---------------------------FSIS---NLSMQTHASRMRTF-M---YWPS-SA PVGPEQLA-----SAGFYYV-GRNDDVKCF------------------------------ ------------CCDG------------------------GLRCWESGDDPWVEHAKWFP --XX---XXXXXX-XXXX-------------XXXXXXXX----------XXXXXXX--LL STSDPPGEENADPP---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------IV HFGPGESSSEDAVMMNTPVV---KAALEMGFSKSLVKQTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SKILTTGENYKTVNDI------------ ----VSALLN--AEDEKREE-EKERQAE---EVAS--DDLSLIRKNR---MALFQQLTC- VLPILDHLLKANVINKQEHDIIKQKTQIPLQARELIDTVLVKG----------------- ------------------------------------------------------------ --------------------------------------------------------NVAA NIFKNCLKEIDSTLYENLFVEKNMK-----YIPTEDA--SG--LSLEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---KEVSIVFIPCGHLVVCQGCAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRGIIKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >H_sapiens_ENSP00000194097 MATQQKASDERISQFDHNLLPELSALLGLDAVQLAKELEEEEQKERAKMQKGYNSQMRSE AKRLKTFVTYEPYSSWI-PQEMAAAGFYFTG---------------VKSGIQCFCCSLIL FGAGLTRLPIEDHKRFHPDCGFLLNKDVGNIAKYDIRVKNLKSRL-R------------- ----------------------------------------------GGKMRYQEE----- ---EARLASFRN-WPF---YV-QGISPCVLSE--------AGFV---FT----------G KQDTVQCF---------------------------------------------------- ----------SCGGCLGNWEEGDDPWK---EHAKWFPKCEFLRSKKSSEEITQYIQSYKG FVDITGEHFVNSWVQRELPMAS-------------------------------------- ---------------------------AYC---NDSIFAYEELRLDSF-K---DWPR-ES AVGVAALA-----KAGLFYT-GIKDIVQCF------------------------------ ------------SCGG------------------------CLEKWQEGDDPLDDHTRCFP --NC---PFLQNM-KSSA-------------EVTPDLQS----------RGELCEL--LE TTSESNLEDSIAVGPIVP------------------------------------------ --EMAQGEAQWFQEAKNLNEQLRAAYTSASFRHMSLLDISSDLATD-HLLGCDLSIASKH ISKPVQEPLVLPEVFGNLNSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYL SLSSTRPDEGLASIICDQLLEKEGSVTEMCVRNIIQQLKNQVLFLLDDYKEICSIPQVIG KLIQKNHLSRTCLLIAVRTNRARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRK FMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDP-SFDDVAVFKSYMERLSLRNKATAE ILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRFL SPAFQEFLAGMRLIELLDSDRQEHQDLGLYHLKQINSPMMTVSAYNNFLNYVSSLPSTKA GPKIVSHLLHLVDNKESLEN-ISENDDY---LKHQPEISL-QMQLLRGLWQICPQAYFSM VSEHLLVLALKTAYQSNTVAACSPFVLQFLQGRTLTLGALNLQ------YFFDHPESLSL LRSIHFPIRGNKTSPRAHFSVLETCFDKSQVPTIDQDYASAFEPMNEWERNLAEKEDNVK SYMDMQRRASPDLSTGYWKLSPKQYKIPCLEVDVNDIDVVGQDMLEILMTVFSASQRIEL HLNHSRGFIESIRPALELSKASVTKCSISKLELSAAEQELLLTLPSLESLEVSGTIQSQD QIFPNLDKFLCLKELSVDLEGNINVFSVIPEEFPNFHHMEKLLI-QISAEYDPSKLVKLI QNSPNLHVFHLKCNFFSDFGSLMTMLVSCKKLTEIKFSDSFFQAVPFVASLPNFISLKIL NLEGQQFPDEETSEKFAYILGSLSNLEELILPTGDGIYRVAKLIIQQCQQLHCLRVLSFF KTLNDDSVVEIAKVAIS-GGFQKLENLKLSINHKITEE---GYRNFFQALDNMPNLQELD ISRHFTECIKAQATTVKSLSQCVLRLPRLIRLNMLSWLLDADDIALLNVMKERHPQSKYL TILQKWILPFSPIIQK--- >R_norvegicus_ENSRNOP00000024483 MAEHGEASEDQVSEFDGECLPELSALLGVDAVQLVKSQEEEENKERMKMKKGFNAQMRSE AKRLKTFVTYDAFKSWT-PQEMAAAGFYYTG---------------VRHGVQCFCCSLIL FGTSLRKVPIESHRKLRPQCEFLSGKDVGNIGKYDIRVKNPETLP-R------------- ----------------------------------------------GGRARYHEE----- ---EARLESFED-WPF---YA-HGTSPRVLSA--------AGFV---FT----------G KRDTVQCF---------------------------------------------------- ----------SCGGCLGNWEEGDDPWK---EHAKWFPKCEFLQSKKSTEEINQYIQSYTG FLHVAGEHFVNSWVRRELPVVS-------------------------------------- ---------------------------AYS---NDSVFANEGLRMDTF-K---DWPH-ES SVAVEALV-----KAGLFYT-GKKDIVQCF------------------------------ ------------SCGG------------------------CMENWKEGDDPIEDHTKFFP --NC---VFLQTL-KSSA-------------EVIPALQS----------HCACPEA--ME TTSESNHEDPVAVHSSVA------------------------------------------ --GLGQSEAQWCQEARSLSEQLRGTYTKASFRHMNLPEAYSSLGTD-HLLGCEVFLISKH VSRPVQVALTIPEVFANLSSVMCVEGEAGSGKTTFLKRIAFLWASGCCPLLNRFQLVFYL SLRSIRADQGLADIICAQLLEAGGCISEVSLSSGIQHLQHQVLFLLDDYSGMDSLPQALD TLITKNYLSRTCLLMAVHTNRVRDIRPYLETVLQIKEFPFYNTISVLRKFFSHNTTRLLE FMVYFGRNEDLQGVHKTPLFVAAVCTDWFQNPSDQ-PFQDVTIFKSYMQYLFLKHKATAG PLQATVSSCGHLALTGLFSSSFEFSSDDLIEAGVDEDEELSTCLMSKFTAQRLRPVYRFL SPLFQEFLAAMRLSELLGSDSQEDQDLGLYYLRQINSPLKAINSYGIFLKYVSDHCSSKA GPKVVSHLLQLVDEKESLEN-MSENEDY---MKLHPETFL-WLHFLRGLWLNSPESFSSL LSERLLNIALNFAYQSSTVAACSPVILQFLRGRTLALGVLNSQ------YFWDHPESLLL LGSLKVSINGNEISSHVDYS-FKTYFENLQPPAIDKEYTSAFEHISEWKRNFAEDEKIIK HYQNIWPRVLPDISEGYWKLSPKPYKIPRLEVGVNNMGPADQALLHVLMEVFSASQSIEF QLFNSSGFLESIRPALELNKTSVTKCSMSRLELSRAEQELLLTLPALQSLEVSETNQIPD QLFHNLDKFLGLKELSVRLDGTQDVLSVLPGEFPNLHHMEKLSI-HTFTESDLSKLVKLI QNSPNLHDIHLKCDFLSNCESLMAALASCEKLREIEFSGRCFEAMPFVTLLPNFVFLKIL NLKGQQFPDKETSEMFAQALGSLRKLEELHLPKGDGIHQVAKLIVQQCLQLPCLRVLAFH HVLDDDSVTEVARVATS-RGFQKLENLDLSMNHKITEE---GYRNFFQALDNLPNLQELN ICRHIRECIQVQASTVKALGQCVSRLPSLTRLRMLSWLLDEEDMKVINDVKERHPQSKRL TVFWKWIVPFSPVVQE--- >M_musculus_ENSMUSP00000112867 MAEHGESSEDRISEIDYEFLAELSARFGMNLVQLAKSQEEEDHKERMKMKKGFNSQMRSE AKRLKTFESYDTFRSWT-PQEMAAAGFYHTG---------------VKLGVQCFCCSLIL FGNSLRKLPIERHKKLRPECEFLQGKDVGNIGKYDIRVKSPEKML-R------------- ----------------------------------------------GGKARYHEE----- ---EARLESFED-WPF---YA-HGTSPRALSA--------AGFV---FT----------G KRDTVQCF---------------------------------------------------- ----------SCGGSLGNWEEGDDPWK---EHAKWFPKCEFLQSKKSSEEIAQYIQDYEG FVHVTGEHFVKSWVRRELPMVS-------------------------------------- ---------------------------AYC---NDSVFTNEELRMDMF-K---DWPQ-ES PVGFEALV-----RAGFFYT-GKKDIVRCF------------------------------ ------------SCGG------------------------CLEKWAEGDDPMEDHIKFFP --EC---VFLQTL-KSSA-------------EVIPTLQS----------QYALPEA--TE TTRESNHDDAAAVHSTVV------------------------------------------ --DLGRSEAQWFQEARSLSEQLRDTYTKTSFCHMNLPEVCSSLGTD-HLLGCDVSIISKH VSQPVQGALTIPEVFSNLSSVMCVEGEAGSGKTTFLKRIAFLWASGCCPLLYRFQLVFYL SLSSITPDQGLANIICTQLLGAGGCISEVCLSSSIQQLQHQVLFLLDDYSGLASLPQALH TLITKNYLFRTCLLIAVHTNRVRDIRPYLGTSLEIQEFPFYNTVFVLRKFFSHDIICVEK LIIYFSENKDLQGVYKTPLFVAAVCNDWNQNASAQDDFQDVTLFHSYMQYLSLKYKATAE SLQATVSSCGQLALTGLFSSCFEFNSDDLAEAGVDEDVKLTTFLMSKFTAQRLRPVYRFL GPLFQEFLAAVRLTELLSSDRQEDQDLGLYYLRQIDSPLKAINSFNIFLYYVSSHSSSKA APTVVSHLLQLVDEKESLEN-MSENEDY---MKLHPQTFL-WFQFVRGLWLVSPESFSSF VSEHLLRLALIFAYESNTVAECSPFILQFLRGRTLALRVLNLE------YFWDHPESLLL LRSLKVSINGNKMSSYVDYS-FKTYFENLQPPAINEEYTSAFEHVSEWRRNFAQDEEIIK NYENIWPRALPDISEGYWNLSPKPCKIPKLEVQVNNMGPADQALLQVLMEVFSASQSIEF HLFNSSGFLESIRPALELSKASVTKCSMSRLELSRAEQELLLTLPALQSLEVSETNQLPD QLFHNLHKFLGLKELCVRLDGKPDVLSVLPEEFLNLHHMEKLSI-RTSTESDLSKLVKFI QNFPNLHVFHLKCDFLSNCESLMTALASCKKLREIEFSGQCFEAMTFVNILPNFVSLKIL SLKGQQFADKETSEKFAQALGSLRNLEELLVPTGDGIHQVAKLIVRQCLQLPCLRVLAFH DILDDESVIEIARAATS-GSFQKLENLDISMNHKITEE---GYRNFFQALDNLPNLQMLN ICRNIPGRIQVQATTVKALGHCVSRLPSLTRLGMLSWLLDEEDMKVINDVKERHPQSKRL TIFWKWIVPFSPVVLE--- >G_gorilla_ENSGGOP00000007398 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MTGYEAWLITF-G---TW---MY SVNKEQLA-----RAGFYAI-GQEDKIQCF------------------------------ ------------HCGG------------------------GLANWKPKEDPWXQXAKWYP --GC---KXLLEE-KGHE-------------YINNIHLT----------RS-LEGA--LV QTTKKT------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---PSLTKRISDTIFPNPML---QEAIRMGFDFKDIKKIME------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------EKIQTSGSNYKTLEVL------------ ----XADLVS--XQKDTTEN-ESNQTSL---QRE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ISPXEPLRRLQ------ ----------EEKLCKICMD---------------------------------------- ---RHIAVVFIPCGHLVTCKQCAEAVDRC------------------------------- ------------------------------------------------------------ -----------------------------PMCNAVIDF---KQRVFMS------------ ------------------------------------------------------------ ------------------- >P_pygmaeus_ENSPPYP00000017359 MATQQKASDERISQFDHDLLPELSALLGLDAVQFVKEIEEEEQKERAKMQKGYNSQMRSE AKRLKTFVTYEPYSSWI-PQEMAAAGFYFTG---------------VKSGIQCFCCSLIL FGAGLTRLPIEDHKRFHPDCGFLLNKDVGNIAKYDIRVKNLKSRL-R------------- ----------------------------------------------GGKMRYQEE----- ---EARLASFKN-WPF---YV-QGIPPCVLSE--------AGFV---FT----------G KQDTVQCF---------------------------------------------------- ----------SCGGCLGNWEEGDDPWK---EHAKWFPKCEFLQSKKSSEEITQYIQSYQG FVDITGEHFVNSWVQRELPMAS-------------------------------------- ---------------------------AYC---NDSIFAYEELRLDSF-K---DWPR-ES AVGVAALA-----KAGLFYT-GIKDIFQCF------------------------------ ------------SCGG------------------------CLEKWQEGDDPLDNHTRCFP --NC---PFLQNM-KSSA-------------EVIPDLQS----------HGELCEL--LE TTSESNPEDSIAVDPIVP------------------------------------------ --EMAQGEAQWFQEAKNLNEQLRAAYTSASFRHMSLLDISSDLATD-HLLGCDLSIASKH ISKPVQEPLVLPEVFANLNSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYL SFSSTRPDQGLASIICDQLLEKEGSVTEMCMRNILQQLKNQVLFLLDDYKEICSIPQVIG KLIQKNHLSRACLLIAVRTDKARDIRRYLETILEIKAFPFYNTVFILRKLFSHNMTRLRK FMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDP-SFDDVAVFKSYMERLFLRNKATAE LLKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRFL SPAFQEFLAGMRLIELLESDRQEHQDLGLYHLKQINSPMMTVSAYNNFLNYVSSLPSTKA GPKIVSHLLHLVDNKESLEN-ISENDDY---LKHQPEISL-KMQLLRGLWQICPQAYFSM VSEHLLVLALKIAYQSNTVAVCSPFVLQFLQGRTLTLGALNLQ------YFFDHPESLSL LRSIHFSIQGNKTSPRAHFSVLETCFDKSQVPTIDQDYASAFEPMNEWERNLAEKEDDVK SYMDMQRRASPDLSTGYWKLSPKQYKIPCLKVNVNDIDAVDHEMLEILMTVFSASQRIEL HLNHSRGFIESIRPALELSKASVTKCSISKLELSAAEQELLLTLPSLESLEVSGTIQSQD QIFPNLDKFLCLKELSVDLEGKINVFSVIPEEFPNFHHMEKLLI-QISAEYDPSKLVKLI QNSPNLHVFHLKCNFFSDFESLMTILASCKKLTEIKFLDSFFQPVPFVAILPNFISLKIL NLEGQQFPDDETSEKFAYILGSLSNLEELILPTGDGIYRVAKLIIQQCQQLHCLRVLSFF KTLNDDSVVEIAKVAIN-GGFQKLENLKLSINHKITEE---GYRNFFQALDNMPNLQELD ISRHFTEVIKTHATTVKSLSQCVLRLPRLIRLNMLSWLLDADDIALLNVMKERHPQSKYL NILQKWILPFSPIIQK--- >C_intestinalis_ENSCINP00000002312 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MFRC-------------------------------- ---------------------------QYPV---SPYMRNEESRFETFDH---RWPASNV RASPRQIA-----IAGFFFL-GDRDRVKCW------------------------------ ------------YCNG------------------------GLQNWDPDDEPWTEHAKWFP --TN-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------IIN------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------RRLTSGGNLYTSVADL------------ ----VDDITA--NENEPNSD-DDDETNT---SQPSQTTTVKT------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------TERKCKICLD---------------------------------------- ---KVADIVFVPCGHLCTCTECAKALRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRSKFER---GIKTYMS------------ ------------------------------------------------------------ ------------------- >M_musculus_ENSMUSP00000113890 MAAQGEAVEEIICEFDDDLVSELSTLLRVDALSVLKRQQEEDHKTRMKMKKGFNSQMRSE AKRLKTFETYDKFRSWT-PQEMAAAGFYHTG---------------VKLGVQCFCCSLIL FSTRLRKLPIENHKKLRPECEFLLGKDVGNIGKYDIRVKSPEKML-R------------- ----------------------------------------------GDKARYHEE----- ---EARLESFED-WPF---YA-HGTSPRVLSA--------AGFV---FT----------G KRDTVQCF---------------------------------------------------- ----------SCGGCLGNWEEGDDPWK---EHAKWFPKCEFLQSKKSPEEITQYVQSYEG FLHVTGEHFVNSWVRRELPMVS-------------------------------------- ---------------------------AYC---NDSVFANEELRMDTF-K---DWPH-ES PGAVEALV-----KAGLFYT-GKRDIVQCF------------------------------ ------------SCGG------------------------CMEKWAEGDNPIEDHTKFFP --NC---VFLQTL-KSSA-------------EVIPALQS----------HCALPEA--ME TTSESNHDDAAAVHSTVVDVSPSEAQELEPASSLVSVLCRDQDHSEAQGRGCASSGTYLP STDLGQSEAQWLQEARSLSEQLRDTYTKATFRHMNLPEVYSSLGTD-HLLSCDVSIISKH ISQPVQGSLTIPEVFSNLNSVMCVEGEAGSGKTTFLKRIAFLWASGCCPLLYRFQLVFYL SLSSITPGQELAKIICAQLLGAGGCISEVCLSSIIQQLQHQVLFLLDDYSGLASLPQALH TLITKNYLSRTCLLIAVHTNKVRGIRPYLDTSLEIKEFPFYNTVSVLRKLFSHDIMRVRK FINYFGFHEELQGIHKTPLFVAAVCTDWFKNPSDQ-PFQDVALFKAYMQYLSLKHKGAAK PLQATVSSCGQLALTGLFSSCFEFNSDNLAEAGVDEDEELTTCLMSKFTAQRLRPVYRFL GPLFQEFLAAVRLTELLSSDRQEDQDLGLYYLRQINSPLKAMSIYHTFLKYVSSHPSSKA APTVVSHLLQLVDEKESLEN-MSENEDY---MKLHPEALL-WIECLRGLWQLSPESFSLF ISENLLRICLNFAHESNTVAACSPVILQFLRGRTLDLKVLSLQ------YFWDHPETLLL LKSIKISLNGNNWVQRIDFSLIEKSFEKVQPPTIDQDYAIAFQPINEVQKNLSEKKHIIK KYEDMKHQIPLNISTGYWKLSPKPYKIPKLEVQVTNTGPADQALLQVLMEVFSASQSIEF RLSDSSGFLESIRPALELSKASVTKCSMSRLELSREDQKLLLTLPTLQSLEVSETNQLPD QLFHNLHKFLGLKELCVRLDSKPDVLSVLPGEFPNLHHMEKLSI-RTSTESDLSKLVKLI QNSPNLHVFHLKCNFLSNCEPLMTVLASCKKLREIEFSGRCFEAMTFVNILPNFVFLKIL NLRDQQFPDKETSEKFAQALGSLRNLEKLFVPTGDGIHQVAKLIVRQCLQLPCLRVLVFA ETLDDDSVLEIAKGATR-GGFQKLENLDLTLNHKITEE---GYRNFFQVLDNLPNLKNLD ISRHIPECIQIQAITVKALGQCVSRLPSLTRLGMLSWLLDEEDIKVINDVKERHPQSKRL TVHWRWVVPFSPVIQK--- >C_intestinalis_ENSCINP00000020067 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------MAE----- ---IDRQDITGLASP--------SLTQHKEAK--------TQILPGRNC----------C ASNSVTAF---------------------------------------------------- ----------DC------------------------------------------------ ------------------------------------------------------------ ---------------------------KHPY---TKNMENFRERIRTF-I---SWPRGVT KATPVEIA-----KAGFFYL-KERDRAKCF------------------------------ ------------YCNG------------------------GLQNWEPNDEPWFEHAKWFP --NC---DFLLRE-KGIE-------------FVQNVAGR----------FPNLNRP--LL NDQATPKPSTSNLQ---------------------------------------------- ------------------------------------------------------------ --------------------------------------------LPAPATSKQTEVPQNS ASHIEITRPTLEEAMESELV---LAVSGFGFERELVQLVVE------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------RLLQETGNVNCTIMEL------------ ----VTATQQ--LEQKQMEE-NAMEVVE---SFNV------------------------- -----------------------NQEKPEMACAQINLSTSPTD----------------- ------------------------------------------------------------ --------------------------------------------------------SFPM QTPGNFTEQQVPGSKKMMYVKQKEV-----SVPELS---EQSLAQQRSQLQNLK------ ----------DEMRCKICLD---------------------------------------- ---NPMDCILLECGHVCTCLECSQGIRTC------------------------------- ------------------------------------------------------------ -----------------------------PICRQKITK---IMKIYRNY----------- ------------------------------------------------------------ ------------------- >E_caballus_ENSECAP00000002314 MATEEKAPAGRDSRFDHALLQELSALLGIDAVQYAKEMEEEEQREREKMQQGFNSRMRSE AKRLKTFATYEAYSSWT-PQEMAAAGFHFTG---------------VRAGVQCFCCGLIL FGASLHKRPLDDHKRLRPDCGFLLGEDVGNVAKYEVRVRKPPGTL-R------------- ----------------------------------------------GDAARYREE----- ---EARLKSFKD-WPF---YA-QATAPRELSA--------AGFV---FT----------G SRDAAQCF---------------------------------------------------- ----------SCGGCLGNWEDGDDPWK---EHAKWFPKCEFLQSKKSSEEIAQYIQSYEG FVGVTGEHFLNSWVKRVVPMVS-------------------------------------- ---------------------------AYS---SDSIFANGELRLDSF-K---NWPP-AS PVGAAALA-----KAGLFYT-GVKDVVQCF------------------------------ ------------SCGV------------------------CLENWKEGDDPVEDHTKYSP --NC---QFLQNM-KSSA-------------GATPDLQS----------RDVIPSP--TK STCESNLADSAAVSSPAP------------------------------------------ --EMAQGEAQWFQEAKGLSERLRKAYTSARFCNTSLLEVAPCLATD-QLLGCDLSLASKR IGSHVQEPVVLPEVFATLNSVMCVEGEAGSGKTVLLKRIALLWASGGCPLLNRFQLVFYV SLSSARPDQGLASILCDQLLETEDSVTEMSLRPIIQQLKNQVLFLLDDFREMCSVPRVIE KLIQRNHSSRTCLLIGVRRSRARAIHRHLHTILEIKAFPFYNSIYILRKLFSHNMIRLRN FMIHFGKNKNLQGIQKTPLFVVAVCAHWFRHPLDQ-SFDDVAVFKSYMECLFLKYKTTAD LLRATVSSCGELALKGFFSSCFEFRDDDLVEAGVDQDEDLAMCLMSKSTAQRLRPVYQFL SPAFQEFLAGMRLTELLDSDRQEDRELGLHYLREVNSSLMAVIPYSNFFNYVSCHASTKA GPKVVSHLLRLVDKKESLEN-ILESDDY---LKHRPEISV-HMEYFRVLWQLSPKYYFSQ VSEHLLALAIKIAYQSNALAACSPFILRFLQGRTLTFNMLKSQ------YFFDHPESLLL LRSIQFSIKGRKSS-RLDLSVLETCLDKSQAPTIDQDYASAFEPAKEWEQNLAEKEENVK SFLDMQLNAPPDISTGYWKLSPKPYKIPLLEVHVTDIDAVDQEMLRVLTAVFSASQHIEL HLNDSRGFLESVRPALEQYKASFTKCSISRFELSAADQELLLTLTSLESLEVSGTTWLRD QLFPNLDKFLCLKELSVDLDDKQNVFSVIPEDFVNLHHMEKLLI-RIAAEHGPSKLVRLI QNSPDLQVFHLQCNFFSDFESLMTVLASCKKLKEIKFSGRFFKAIPFVIVLPNFTSLKML NLGHQEFPDRETAEKFAYTLGSLDNLEELILPTGDAVHQVAKLIVQQCEHLRGLRVLSFY QTLNDDSLMEIVRALTSGGGFQKLENLNLSINHKITEE---GYRNFFQALDSLPRLQELT ISRHFTECIKAQAATVKSLSQCVSRLPSLIRLNMLSWLLDAEDVTLLTAMKERHPQSKHL TFHWKWILPFSPIIQK--- >C_intestinalis_ENSCINP00000005161 -------------------------------------------------------DSAME SYRLSTFMKYPQDTPVN-PRHLATAGLYFTG---------------YKDRVKCFCCGLAT EQWQFGDD-EKSPRWHRSNCEFIQGHDCGNIPIGLHCVVKYKLLMEL------TIPIFLG SWGWIRPDNTARENFM-NVTYLNLGEKNFFQRIELATISSVYHEQVLRSLDLKKE----- ---GERMKSFEN-WPT---QN-RTVNPSDLAR--------SGFF---YL----------G NLDRVQCF---------------------------------------------------- ----------SCGGVLRNWNYGDNITA---EHRRHFPHCRMTQGTESNN----------- -------------------RELEMMFPC-------------------------------- ---------------------------QHPV---NSHMRHLDSRIVTFDS---RWPKNKT QATIQQIA-----KAGFFYL-GERDRVKCW------------------------------ ------------YCNG------------------------GLQNWDPDDEPWTEHAKWFP --TC---EFLIRS-KGPD-------------FVHHMVSL----------YPNLPRP--IL QTAQGANGSQ-------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------SSGTSSAPIII DPQKRKLREKLNLEMDRDIV---KCVNDMGFELKHIRLCVK------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------RKLEKENIGFSSAQQL------------ ----IDEILKLNLDEEEEEE-LDLETDP---KEPAAMET-EGGKLYHEVKPSNFKRYLDQ RCTINIRLKLDLTTIVMH------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------RFIN QRFIPYVNTVRLETTNRSKNDLYYFKYLKQNWLTNGACMVDLTMSMQDRLLELQ------ ----------NERKCKICVD---------------------------------------- ---KLSDIVFVPCGHLCVCQACKSKVARC------------------------------- ------------------------------------------------------------ -----------------------------PICKSKVEK---SIRTYMS------------ ------------------------------------------------------------ ------------------- >X_tropicalis_ENSXETP00000030727 ----------------------------NEILDR-RPDLAKRLKSNPSMCKI-TLEFSCE LYRLSTFSSFPSNTHVS-ERNLAKAGFYYTG---------------QDDKVKCFTCGLML DNWKKGDNAFEKHKKLYPSCSFIQNVPSVN-LGASLYSAFSPPASNS---------TP-- --MHA-ASAENDKVEA-ITLKYSS-IPQDPVTLRGIEDLSHVR-ISEY---MYTE----- ---EARLNSFQE-WSN---M---FLTPAELAK--------AGFY---FV----------G PGDKVACF---------------------------------------------------- ----------TCDGKLNNWEPNDNAMS---EHRRHFPNCPFVKSSTRVS----------- ----------SR------------------------------------------------ ---------------------------FSVS---NVSMQASSARLKTF-A---SWPP-RI PISPTRLA-----EAGFYYV-GRNDDV--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------- >M_musculus_ENSMUSP00000022142 MAEHGESSEDRISEIDYEFLPELSALLGVDAVQLAKSQEEEEHKERMKMKKGFNSQMRSE AKRLKTFETYDTFRSWT-PQEMAAAGFYHTG---------------VKLGVQCFCCSLIL FGNSLRKLPIERHKKLRPECEFLQGKDVGNIGKYDIRVKSPEKML-R------------- ----------------------------------------------GGKARYHEE----- ---EARLESFED-WPF---YA-HGTSPRVLSA--------AGFV---FT----------G KRDTVQCF---------------------------------------------------- ----------SCGGSLGNWEEGDDPWK---EHAKWFPKCEFLQSKKSSEEIAQYIQGYEG FVHVTGEHFVNSWVRRELPMVS-------------------------------------- ---------------------------AYC---NDSVFANEELRMDTF-K---DWPH-ES PVAVDALV-----RAGLFYT-GKKGIVQCF------------------------------ ------------SCGG------------------------CMEKCTEGDDPIQEHNKFFP --NC---VFLQTP-KSSA-------------EVIPALQS----------HCALPEA--ME TTSESNHDDPAAVHSTVV------------------------------------------ --GLGRSEAQWFQEARSLSEQLRDNYTKATFRHMNLPEVCSSLGTD-HLIGCDVSIISKH ISQPVQGALTIPEVFSNLSSVMCVEGETGSGKTTFLKRIAFLWASGCCPLLYRFQLVFYL SLSSITPDQGLANIICAQLLGAGGCISEVCLSSIIQQLQHQVLFLLDDYSGLASLPQALH TLITKNYLSRTCLLIAVHTNRVRGIRSYLDTSLEIKEFPLSNTVYILKKFFSHNIKRLLE FMVYFGQNEDLQGIHKTPLFVAAVCTDWFENPSDQ-PFQDMALFKSYMQYLSLKHKGAAK PLQATVSSCGQLALTGLFSSCFEFNSDDLAEAGVDEDEELTTCLMSKFTAQRLRPVYRFL GPLFQEFLAAMRLTELLSSDRQEDQDLGLYYLRQINSPLKALTTYNNFLKYVFSHPSSKA GPTVVSHLLHLVDETELLEN-TYKNEDY---VNHPPGTSR-IMKGLKELWLLSPEYYSSF VSEHLLRIALNFAYESNTVAECSPFILQFLRGRTLALKVLNLQ------YFRDHPESLLL VKSLEVSINGNKVPKVVDYSVMEKSFETLQPPTIDQDYASAFEQMKEHEKNLSENEETIK SIKNIFPLQPPKISSGYWKLSPKPCKIPRLEVGVTNMGPADQALLQVLMEVFSASQSIEF RLSDSSGFLESIRPALELSKASVTKCSMSRLELSRAEQELLLTLPALQSLEVSETNQLPD QLFHNLHKFLGLKELCVRLDGKPDVLSVLPGEFPNLLHMEKLSI-RTSMESDLSKLVKLI QNSPNLHVFHLKCDFLSNCDSLMAVLASCKKLREIEFSGRCFEAMPFVNILPNFISLKIL NLISQQFPDKETSEKFAQALGSLRNLEELLVPTGDGIHQVAKLIVRQCLQLPCLRVLAFH YILDNDSVIEIARVATS-GGFQKLEKLDLSMNHKITEE---GYRNFFQALDNLPNLQNLN ICRHIPECIQVQATTVKALGQCVSRLPSLTRLHMLSWLLDEEDMKVINDVKERHPQSKRL IIFWKWIVPFSPVVLE--- >C_intestinalis_ENSCINP00000000487 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MSIELFKE----- ---ENRRETFKT-WSA---AF-NDEFVKELAR--------SGFF---YL----------G NLDRTQCF---------------------------------------------------- ----------SCSGVLRNWRASDDVNV---EHFRHFPHCKMGSNSESKNVP-----LPLD HPIDVDDIPEPPDPSPKEQENLVKMFTL-------------------------------- ---------------------------GAPM---NPHMRSLDARVATFDR---RWPARKV KASATHIA-----KAGFYFL-GDRDRAKCW------------------------------ ------------YCNG------------------------GLQNWDANDEPWVEHAKWFP --GC---EFVLRN-KGIA-------------FVHEIYTN----------NPNLNRP--EI QNARSEYLTSPKKN---------------------------------------------- ------------------------------------------------------------ ------------------------------GGVMISQTATITAGDVLANYLPPPPPDGVE RSPETGSATDVDAMMKNEVV---SVVTSMGFGHDLIRKAVE------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------KHISNNGSNPPTTEGL------------ ----LELILQ--LDENDDVI-ADDVING---DVMQDDIGAIGGIVISQGEGVETKSSLKR NNDKAEQDSDQKPMKQQKFD---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TNAFEELESLE------ ----------MERRCRACRN---------------------------------------- ---HVADTVVMPCGHLCFCSSCSSSSKRC------------------------------- ------------------------------------------------------------ -----------------------------GLCREKIQS---VMKVYLS------------ ------------------------------------------------------------ ------------------- >X_tropicalis_ENSXETP00000016312 ------------------------------------------YSGSQNPGEKPLGDMNDE YSRLETYRGHSQYFPMANQRKLAQAGFSYVG---------------PGDRVRCISCGGEL EKWERWDVPLTRHQHSFPHCPYMQKLRDEGDGKENQSKVCAGPIKEG------------- ------------------------------ESGTTVPLSSSSNLEKKPCGYMSDE----- ---YSRLESYRG-HGQ---HF-NYWNQQRLAKQTSDELAWAGFF---YV----------G PGDRVRCF---------------------------------------------------- ----------SCGGEVDNWEPGDVPLT---GHQLFFPHCSYVQGLSIRHSYFMEEGVGPG FL---------------------------------------------------------- ----------------------------------DTNILGN--RIQSY-Q---AVKEHFP NQTPIKLA-----WAGFYYV-GPKDKVQCF------------------------------ ------------SCGG------------------------EMDKWWSREDPLTEHHRRFP --QC---HFILGR-KAVS------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------NDPYTMTEMLKGLN------ ----------NQQSQPT------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------- >C_intestinalis_ENSCINP00000000510 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MSIELFKE----- ---ENRRETFKT-WSA---AF-NDEFVKELAR--------SGFF---YL----------G NLDRTQCF---------------------------------------------------- ----------SCSGVLRNWRASDDVNV---EHFRHFPHCKMGSNSESKNVP-----LPLD HPIDVDDIPVPPDPSPKEQEDLVKMFTL-------------------------------- ---------------------------GAPM---NPHMRSLDARVATFDR---RWPARKV KASATHIA-----KAGFYFL-GDRDRAKCW------------------------------ ------------YCNG------------------------GLQNWDANDEPWVEHAKWFP --GC---EFVLRN-KGIS-------------FVHEIYTN----------NPNLNRP--EI QNARSEYLTSPKKN---------------------------------------------- ------------------------------------------------------------ ------------------------------GGVMISQTATITAGEVLANYLPPPPPDGVE RSPETGSATDVDAMMKNEVV---SVVTSMGFGHDLIRKAVE------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------KHISNNGSNPPTTEGL------------ ----LELILQ--LDENHDVI-ADDVING---DVMQDDIGAIGGIVISQGEGVETKSSLKR NNDKAEQDSDQKPM---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------- >C_intestinalis_ENSCINP00000000045 ----------------------------------------------------------ME SYRLSTFMKYPQDTPVN-PRHLAAAGFHYTG---------------YKDRVKCFCCGLCV ESWCVGDD-VKSPRWHRSNCEFILGQDCGNQPIGSQNISVQQTARPV--------PAGMI MKS-G-PSEFRFTFVI--LTFLTLYSTR--PKVELATIASPYHEQLVRSLDLRKE----- ---SDRFKTYEN-WPA---QN-RTVYASDLAR--------SGFF---YL----------G NLDRVQCF---------------------------------------------------- ----------SCGGVLRNWNYGDNITA---EHRRHFPHCRFVRKKTVYQ----------- ----------------TANVLRG------------------------------------- ---------------------------GFFTNQFIPYMRNEESRFETFDH---RWPASNV RASPRQIA-----KAGFFFL-GDRDRVKCW------------------------------ ------------YCNG------------------------GLQNWDPDDEPWTEHAKWFP --TH--REVVGKY-KGPD-------------FVHRMVSL----------YPNLPRP--IL RGPFDVPPRVPGAN---------------------------------------------- ------------------------------------------------------------ -------------------------------------------------QRAPSPPPPII DHKVAKQQEQVNKFMLGDLV---KSATEMGFETSVIRRVVT------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------RRLTSGGNLYTSVADL------------ ----VDDITA--NENEPNSD-DDDETNA---SQPSQTTTVKTPGDYDVINVTIVLRYILD RPIIHCKQEQTKWR---------------------------------------------- ------------------------------------------------------------ --------------------------------------------------------PV-- -KQKQQLEELFDRHFIKFFRNKVGIKSLKIITNIVWWWLRYVTPSMEARIRELQ------ ----------EERKCKICLD---------------------------------------- ---KVADIVFVPCGHLCTCTECAEALRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRSKIRERDQNLHIYVGW----------- ------------------------------------------------------------ ------------------- >C_intestinalis_ENSCINP00000011648 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MA-----AAGLFYI-GQTDRVKCW------------------------------ ------------YCNG------------------------GLQNWLPNDDPWFEHAKWFP --TC---EYVLQQ-RGPE-------------YVHNVCMQ----------FPNLRRP--DL PLRNLPSVVSGPSH---------------------------------------------- ------------------------------------------------------------ -----------------------------------------QTPGGGLLYHQSPQIIDPR EETRRRKAKIDREMIASPLV---NQARQLGFSNNQIRSAFT------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------KSFEVSDKTCENMDEL------------ ----IDIISNLPNDDHDQAR-GSNEQTT---SYQYSSTAT-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LSRAEEIRAIE------ ----------ESKICKVCRN---------------------------------------- ---ANACIVLLPCGHLSVCQGCSVNIERC------------------------------- ------------------------------------------------------------ -----------------------------PICRTFTRE---KLLTYLV------------ ------------------------------------------------------------ ------------------- >C_intestinalis_ENSCINP00000021651 --------------------------MLVDSFCSNLKYQTMFHNIDRVSQHAAAMDYSSK SNRIQSLENFPS-APVN-PIQLAIHGFYFTG---------------VEDCVVCFSCENSV RNWKLGDKEGDK-KWHKPDCVFFNSLSQTVNDTNISTPNHQDMNHFV------------- ---------------------------------NTNPTEVVFETMLLKRLTHKSI----- ---KLNIRTFDY-WPH---QL-REVNTAALAK--------YGFY---YL----------G ISDMVECF---------------------------------------------------- ----------CCSNVLGNWNVDDNPKN---RHLERFPNCRWVADVEVHQHPHL------- ------------------------------------------------------------ ---------------------------LHPH---NAHMRSLEQRRSSFRG---FSPRHHL RATIDEIA-----EAGFYFL-GPGDLVKCW------------------------------ ------------YCGN------------------------KLKNFDVEDEPWMEHAKWFP --QLSIPEFLLQN-KGHA-------------FVANIQTS----------YPRNVHV---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --VNLPSVESGPTFLPSPI----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------QNHETL-SHEKVDN---I---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------SSGQSNSN------ ----------SQLCCKVCLN---------------------------------------- ---RDATIAFNPCGHLCVCQSCSPRLNAC------------------------------- ------------------------------------------------------------ -----------------------------PICRRSIQQ---KIRIYFP------------ ------------------------------------------------------------ ------------------- >X_tropicalis_ENSXETP00000034890 ------------------------------------------------------------ -----------KHFPYMKEWDLAQAGFYYVG---------------PGDRVRCISCNAEL EKWEKWDEPLTRHQHSFPDCAYVQEQRAQTTGTQDQSQVCPMPIKEG------------- ------------------------------ESGIPARYSGSHNPGEKPLGDMNDE----- ---YSRLETYRG-HSQ---YF-PMANQRRLAQ--------AGFS---YV----------G PGDQVRCF---------------------------------------------------- ----------SCGGELEKWERWDVPLT---RHQHSFPHCHYIYGRKTGY-------IGIP LLRPL------------------------------------------------------- ---------------------------GEVS---ETQLLYGRRSWTGF-S---GHQHPRE DQTPIKLA-----WAGFYYV-GPKDKVRCF------------------------------ ------------SCGG------------------------EMDEWWSREDPLTEHHRKFP --QC---HFILGR-KAVS------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------NDPYTMTEMLKGLN------ ----------NQQSQPT------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------- >G_gorilla_ENSGGOP00000005705 ----------------------------MNIVEN-SIFLSNLMKSAN-TFEL-KYDLSCE LYRMSTYSTFPAGVPVS-ERSLARAGFYYTG---------------VNDKVKCFCCGLML DNWKRGDSPIEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNS------------- --THS-LLPGTENSGY-FSGSXSN-SPSNPVNSRANQDFSALM-RSSYHCAMNNE----- ---NARLLTFQT-WPL---T---FLSPTDLAK--------AGFY---YI----------G PGDRVACF---------------------------------------------------- ----------XXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXX----------- ----------XX------------------------------------------------ ---------------------------XXXX---XXXXXXXXXXXXXX-X---XXXX-XX XXXXXXXX-----XXXXXXX-XXXXXXXXX------------------------------ ------------XXXX------------------------XXXXXXXXXXXXXXXXXXXX --XC---EYLIRI-KGQE-------------FIRQVQAS----------YPHLLEQ--XX XXXXXXXXXXXXXX---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------XI HFEPGEDHSEDAIMMNTPVV---NAAVEMGFSRSLVKQTVQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------RKILATGENYRLVNDL------------ ----VLDLLN--AEDEIREE-ERERAXX---XXXX--XXXXXXXXXX---XXXXXXXXX- XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----------------- ------------------------------------------------------------ --------------------------------------------------------XXXX XXXXXXXXXXXXXXXXXXXXXXXXX-----XXXXXXX--XX--LPVEEQLRRLQ------ ----------EERTCKVCMD---------------------------------------- ---KEVSIVFIPCGHLVVCKDCAPSLRKC------------------------------- ------------------------------------------------------------ -----------------------------PICRSTIKG---TVRTFLS------------ ------------------------------------------------------------ ------------------- >O_cuniculus_ENSOCUP00000002871 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------QQDKMRCF------------------------------ ------------FCYG------------------------GLQS-ERGDD-WTEHAKWFP --RC---QFLLRS-KGRD-------------FVHSIQES----------GSQLLGP--WD LWEEPE------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DT APASPSGPVHQ------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APELLT--PRTEPWLE-SAREPGG---TRAR--LRVQRVLGPP------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GAGAVAMEEQLRRLQ------ ----------EERTCKVCLD---------------------------------------- ---QAVSVVFVPCGHL-VCTQCAPNLHLC------------------------------- ------------------------------------------------------------ -----------------------------PICRAPVRS---CVRTFLS------------ ------------------------------------------------------------ ------------------- >X_tropicalis_ENSXETP00000016315 ------------------------------------------------------------ -----------KHFPYQTSDKLAWAGFFYVG---------------PGDRVRCFSCGGEV DNWEPGDVPLTRHQLFFPHCSYVQGLSIRHSY---------------------------- ----------------------------FMEEGVGPGFLDTNILGKE--GDMSDE----- ---YSRIQSYQA-VKE---HF-PNQTPIKLAW--------AGFY---YV----------G PKEKVRCF---------------------------------------------------- ----------SCGGEMDEWWSREDPLT---EHHRRFPQCHFILGRKEGNPP--------- ------------------------------------------------------------ ---------------------------GKGSLPSPRIFLCPRKCLEAQ-L---DFPCLLH HQTPIKLA-----WAGFYYV-GPKDKVQCF------------------------------ ------------SCGG------------------------EMDKWWSREDPLTEHHRRFP --QC---HFILGR-KAVS------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------NDPYTMTEMLKGLN------ ----------NQQSQPT------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------- >X_tropicalis_ENSXETP00000057704 ------------------------------------------------------------ ------------------QNKLANAGFYYVG---------------PEDRVRCFSCGGQF EMWEEWDFPLTRHQQTFPECPYLQELKAKGEWKDCHYEPGLGSNILM------------- ---EKPLGDLSDERRR-LETFRGHSGLFPYNRVKFLAIQSPNILGKKSHYDMTNM----- ---YSRADTYRG-HHK---HFLPYMKEWDLAQ--------AGFY---YV----------G PGDRVRCI---------------------------------------------------- ----------SCGGELEKWERWDVPLT---RHQHSFPHCPYMQKLRDEGDG--------- ------------------------------------------------------------ ---------------------------GTVS---ILYIGTNRAWLRQVST---MWGP-RT GSRENKLA-----NAGFYYV-GPRDRVRCF------------------------------ ------------SCGG------------------------QLEMWEEWDFPLTRHQQTFP --EC---PYLQEL-KAKG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---EWQLIMMAQAGF--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------- >C_intestinalis_ENSCINP00000000047 ------------------------------------------------------------ ---MQTARVVEPTKPAS------------------------------------------- ------------------------------------------------------------ ----------------------------QYQRVELATIASPYHEKLVRSLDLRKE----- ---SDRFKTYEN-WPA---QN-RTVYASDLAR--------SGFF---YL----------G NLDRVQCF---------------------------------------------------- ----------SCGGVLRNWNYGDNITA---EHRRHFPHCRMVQGTETRNVASAVP-PPQP IPPRGPGIQEPPDPNETEMRDLMNMFRC-------------------------------- ---------------------------QYPV---SPYMRNEESRFETFDH---RWPASNV RASPRQIA-----KAGFFFL-GDRDRVKCW------------------------------ ------------YCNG------------------------GLQN---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------- >O_cuniculus_ENSOCUP00000014265 -----------MHKTASQRVVPGTSYRIKSMMED-STISSNTNDQNQ---KM-KYDFSYK I-RVPTYSGLPIRVPLS-EWSLAPAGLYYIG---------------MN-KVKCFCCDLML DNWKQEYNLIEKHKQLYPSCSFSQNLISVS-LESPLRSSF-------------------- --AHP-LFPTQGPCVS-FSGSYPS-LSANPPNLTSV-DFSPLR-TS-LGYSMSTE----- ---EAR---FYY-KPF---S---FLLPSEFAR--------AGFS---NV----------A PGDAVAGF---------------------------------------------------- ----------ACDRKQSNWK-KDDAML---E-WRHVPN-PFLEI---------------- ----------LR------------------------------------------------ ---------------------------FSIS---NWSMQAH-AQMSTN-M---YWPS-SD PVCPEQLA-----TVDFYYV-ALSDDIKCF------------------------------ ------------CCDG------------------------ALR-FECGDDA-VEHAKLFA --RC---EFLMGV-KG-E-------------FVDEIQDR----------FPHLHQQ--LL -TSDPLGEENADPP---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------IF HFGPGSS-SDDKGMMNTLVV---KSVLEMSFNISFAKETVH------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SKTLPTRENHKTVNDI------------ ----ASTLLN--AEDEKRGE-E--RQAE---E-----------RANS---MTLFQQLVC- VLPILNHLLKVNVIN-KENDIIRQK-QKPLQAIELVDTVLLKG----------------- ------------------------------------------------------------ --------------------------------------------------------IVAA NTFKNCLKDIDSMLYKN-FEKKNTK-----YFPTEDI--SC--PSLGDQLRRLQ------ -----------EVTFKMCID---------------------------------------- ---KEVSILFIPSSNLVVCQACAHSLRKY------------------------------- ------------------------------------------------------------ -----------------------------PICRGIIKG---TVCTFLSK----------- ------------------------------------------------------------ ------------------- >A_aegypti_AAEL001765-PA ----------------------------------------------MPNRTTDQQPTVDY KARLERKQCLAKETPEP-IYDLADCNLKDVP---------------SGVFIMCKVLRKEL LSLASNKLTSLNGGGALVDLHLLVTLNLSNNRFKKLPDEIYRLENLR------------- -----------ELFVS-NNSLEKLPVTINRLKKLELLDVSVNNLTTLEQVSFMPQLRILN ICGNVRLDKLPNQLATCDNLVDIVLDPNTVSEPPADVTTGGTYAIIKYLSTGEIIHRPPS PEDQQDSY---------------------------------------------------- ----------TRSTINFIASERDELRQVELAREKHEKERKLMESERMAYEKDYLAESKLH EQQQRKKQELLEQLLLQQNQNDSNVNRL-------------------------------- ----------------------------------QEEKQSERQRLINDIL---KDEQHSS ELVNNLLALKNGPDAAFLER-EREDQER-------------------------------- ----------------------------------------LVEQLRIQQNDFRKQEILTA --MT---DLLENEINVIQNFHNQRDQSSRNILEREYETNNLLNNVFLNYDRNRQDIIGQI NCDEEIQKS--------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------AV AALIAKNDSRTWGLVEQVRIVESQLAALTTYEIERKKTNQD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------DQINNLAEQRMNLTYV------------ ----LMDLLKQQDQRKQQLL-DTLKIIE---RQKEGEQTDFWLMQYQKLLDHQPSEITND TASVDPILGYQFLENGVVHCLPFLSKIWQNRDKELASVSDQDL----------------- ------------------------------------------------------------ -----------------------------------------------------------I EAGVQNPSDRAAILTSINNYYDYLNRRIEYPEAELSPSTSTPTAPTEETDRELEIPSSPP EEPSNVGAAVQFSECVVCLE---------------------------------------- ---ETVQVIFLPCGHMCCCAGCHISIRDC------------------------------- ------------------------------------------------------------ -----------------------------PLCRAYIER---KIKVIQP------------ ------------------------------------------------------------ ------------------- >M_domestica_ENSMODP00000026850 ----------------------------MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGG EGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDLRILDSAPTGIKHDGTMCDTCRQQP IIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLES------------- ----------------------------RRKSKKITARGIFAGARVVRGVDWQWEDQDGG NGRRGKVTEIQD-WS--------ASSPHSAAYVLWDNGA-KNLYRVGFE----------G MSDL-KCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLEIVQSLQHGHGG WTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANVVRSGDAAQGAEGGT SQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPT------------------------- ---------------------------LGKVGRVQQIYSDSDLKVEVCGT---SWT--YN PAAVSKVA-----SAGSAISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVE DLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGD --EGAVIEVLHRG-SADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDT PLHDAISKKRDDILAVLL------------------------------------------ ------------------------------------------------------------ --EAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAAL NNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIV------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------RLLVRAGAKLDIQDKDGDTP-------- ----LHEALRHHTLSQLRQL-QDMQDVG---KVDTAWEPSKNTLIMGLGTQGAEKKSAAS IACFLAANGADLSIRNKKGQSPLDLCPDPSLCKALAKCHKEKV----------------- ------------------------------------------------------------ --------------------------------------------------SGQVGSRSPS MISNDSETLEECMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICKEQVQSRT------ ----------KIEECVVCSD---------------------------------------- ---KKAAVLFQPCGHMCACENCANLMKKCVQCRAVVERRVPFIMCCGGKGSEDATDDIAS GNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGT------- ------------------CQLCGDRMSECPICRKAIER---RILLY-------------- ------------------------------------------------------------ ------------------- >B_taurus_ENSBTAP00000009822 ----------------------------MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGG EGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDLRILDSAPTGIKHDGTMCDTCRQQP IIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLES------------- ----------------------------RRKSKKITARGIFAGARVVRGVDWQWEDQDGG NGRRGKVTEIQD-WS--------ASSPHSAAYVLWDNGA-KNLYRVGFE----------G MSDL-KCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLEIVQSLQHGHGG WTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRSGDAAQGAEGGT SQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPT------------------------- ---------------------------LGKVGRVQQIYSDSDLKVEVCGT---SWT--YN PAAVSKVA-----SAGSAISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVE DLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGD --EGAVIEVLHRG-SADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDT PLHDAISKKRDDILAVLL------------------------------------------ ------------------------------------------------------------ --EAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAAL NNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIV------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------RLLVRAGAKLDIQDKDGDTP-------- ----LHEALRHHTLSQLRQL-QDMQDVG---KVDAAWEPSKNTLIMGLGTQGAEKKSAAS IACFLAANGADLSIRNKKGQSPLDLCPDPSLCKALAKCHKEKV----------------- ------------------------------------------------------------ --------------------------------------------------SGQVGSRSPS MISNDSETLEECMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLLCKEQVQSRT------ ----------KIEECVVCSD---------------------------------------- ---KKAAVLFQPCGHMCACENCASLMKKCVQCRAVVERRVPFIMCCGGKSAEDATDDISS GNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGT------- ------------------CQLCGDRMSECPICRKAIER---RILLY-------------- ------------------------------------------------------------ ------------------- >G_gallus_ENSGALP00000024106 ----------------------------MSSSRNNRVMVEGVGARVVRGPDWKWGKQDGG EGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDLRILDSAPTGIKHDGTMCDTCRQQP IIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLES------------- ----------------------------RRKSKKITARGIFAGARVVRGVDWQWEDQDGG NGRRGKVTEIQD-WS--------ASSPHSAAYVLWDNGA-KNLYRVGFE----------G MSDL-KCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLEIVQSLQHGHGG WTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANVVRSGDAAQGAEGGT SQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPT------------------------- ---------------------------LGKVGRVQQIYSDSDLKVEVCGT---SWT--YN PAAVSKVA-----SAGSAISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVE DLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGD --EGAVIEVLHRG-SADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDT PLHDAISKKRDDILAVLL------------------------------------------ ------------------------------------------------------------ --EAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAAL NNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIV------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------RLLVRAGAKLDIQDKDGDTP-------- ----LHEALRHHTLSQLRQL-QDMQDVG---KVDTAWEPSKNTLIMGLGTQGAEKKSAAS IACFLAANGADLSIRNKKGQSPLDLCPDPSLCKALAKCHKEKV----------------- ------------------------------------------------------------ --------------------------------------------------SGQVGSRSPS MINNDSETLEECMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICKEQVQSRT------ ----------KIEECVVCSD---------------------------------------- ---KKAAVLFQPCGHMCACENCASLMKKCVQCRAVVERRVPFIMCCGGKGTEDTTDDISS GNIPVMQKDKDNTNVNADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGT------- ------------------CQLCGDRMSECPICRKAIER---RILLY-------------- ------------------------------------------------------------ ------------------- >T_guttata_ENSTGUP00000010673 ----------------------------MSSSRNNRVMVKGVGARVVRGPDWKWGKQDGG EGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDLRILDSAPTGIKHDGTMCDTCRQQP IIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLES------------- ----------------------------RRKSKKITARGIFAGARVVRGVDWQWEDQDGG NGRRGKVTEIQD-WS--------ASSPHSAAYVLWDNGA-KNLYRVGFE----------G MSDL-KCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLEIVQSLQHGHGG WTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANVVRSGDAAQGAEGGT SQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPT------------------------- ---------------------------LGKVGRVQQIYSDSDLKVEVCGT---SWT--YN PAAVSKVA-----SAGSAISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVE DLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGD --EGAVIEVLHRG-SADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDT PLHDAISKKRDDILAVLL------------------------------------------ ------------------------------------------------------------ --EAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWI-DEKKDDGYTALHLAAL NNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIV------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------RLLVRAGAKLDIQDKDGDTP-------- ----LHEALRHHTLSQLRQL-QDMQDVG---KVDTAWEPSKNTLIMGLGTQGAEKKSAAS IACFLAANGADLSIRNKKGQSPLDLCPDPSLCKALAKCHKEKV----------------- ------------------------------------------------------------ --------------------------------------------------SGQVGSRSPS MINNDSETLEECMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICKEQVQSRT------ ----------KIEECVVCSD---------------------------------------- ---KKAAVLFQPCGHMCACENCASLMKKCVQCRAVVERRVPFIMCCGGKGTEDTSDDISS GNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGT------- ------------------CQLCGDRMSECPICRKAIER---RILLY-------------- ------------------------------------------------------------ -------------------