>D_melanogaster_FBpp0075677 ---------------------------------------------M-NI----------- ---VGEYEYSSKDMLGHGAFAVVYKGRHR-KKHMPVAIKCITKKGQLKTQ--NLLGKEIK ILKELTELHHENVVALLDCKESQDCVSLVME--YCNGGDLADYLSVKGTLSEDT------ ------------------VRLFLVQLAGAMKALYTKGIVHRDLKPQNILLSHNYGKTLPA -----------PSKITLK----I-----ADFGFARFLNEGA-MAATLCGSPMYMAPEVIM SLQYD-SKADLWSLGTIVYQCLTGKAPF-YAQ-TPNELKSYYEQNANLAPKIPS--GVSP DLRDLLLCLLRRNSKDRISY--ESFFVHRFLQGKKAAVSP-----VDMPPLGGTPPAKAK SPLQQQLEQELKLV---KLAEQQQKEREEQEAQEDENTVSVVANPAICATITNVG--VLC DSE-----NNSGSCSSHEDSDDFVLVPKNLP-EDQRQGLAQVQAQPASGGQRPQQQQNQ- ---------------------------------------------------------SSP PRPSSL----------------PISEPKPVPAPAR---RQVARPGP-------------- ------------------------LTVATLG----------------------------- ----GQQIP--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RSQPISVK------------------------- -------------------QPRPDQRKSSVSSDINSISPPAVQFAIGTPPT--RMRSASG GSLSETPPPHAPSTWQ--------------------VSPGHSQSPLR------------- ---------------------------------------------RSGNSSPVLP----- -----------------------------------------------------SAALTKL PTLGSPTMLVAPGSLG----SIGSAGSGS----ENNNQH-----------------HMLG PRAFT-----------L--PELGATGGLHSLLDTGAGGGGEPHAFQAPELSEETLMD--R EHNETLSKLNFV--LALTDCIQEVADSRCAPLSTFMVAGSQSAAQAASADAQQIPPHAPE HCKRAERLVLLVRGLQLLSSGMNLASQQLSNGQLKPS--SN------------------- -VKN-ALLTMNAKYRSMLFESKRLN----------------GSGLL-QKANAFNITADKI LYDYALDMCQAAALDELLKNTKNCF-ERYNTAHILLHSLVQKCN---------------- ------------------------------------------------------------ ------------------------------------------------H--PQDKMMLN- -KYRDAVEKRLSILQQHGYIYMTDENA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >A_gambiae_AGAP011295-PA ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------YCNGGDLADYLAVKGTLSEDT------ ------------------IRLFLGQLANAMKALYQADVVHRDLKPQNILLSHNCGKGLPI -----------PSKITLK----I-----ADFGFARFLQDGN-MAATLCGSPMYMAPEVIM SLQYD-AKADLWSLGTIVFQCLTGKAPF-QAH-TPQELKMFYERNANLAPKIPS--GTSK ELTDLLMGLLRRNAKERMNF--DTFFNHPFLQRAETPQGK-------------NGFNIAE VTVAIPLRESVSIL---LLFLLKCVLQRRRCAVLV--AVVVFNTFFLCVSFFPVPIAELD DSVATIS-ANHTSNSSPEESDDFVLVPNNIP-VDPAHGGSYDKSKPTRVPQPMSQAQ--- ---------------------------------------------------------ASP PRPSTL----------------PISEPKPVPTAARKVSRAQAQTPP-------------- -----------------KVCVCVCVCVANIAFALRSS----------------------- LFFQNNSIP--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RSEPINMK------------------------- ---------------------RSENRGS--NCDIRSISPPAVQFAIGTPPSCGRRRSTSG GSLSETPP--PPSCWT--------------------VSPGSHQSPLR------------- ---------------------------------------------RSGTSSPVM------ -----------------------------------------------------NNALSKL PALGSPTTLM----------------GGV----ENNNHHHHHHHG-----------HPLT ARAFT-----------L--PELGAAGGLQSYLDDHTID-DHPINFHAPELHAETLLD--R DHNETLAKLNFV--VALTDCILDVADSRCAPLSSMM-----------LADAQPVPPHQPE HCKRAERLVLLVRALHLLSAGMNLASAQIRAGNLKPS--NS------------------- -VKN-VLTTMHAKYRSTLIESKKLN----------------SAGLL-QRANASNITADKI IFEFALQMCQMAAVDELFNKPAECF-PRYQSAQILLHWLAQKSK---------------- ------------------------------------------------------------ ------------------------------------------------H--PQDKILLS- -NYKEAVEKRLYILKGQGYIYTTDELS--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >A_aegypti_AAEL003819-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MRPA-------------- -----------PSSVCTK------------------------------------AARTIM --------------------------PL-------------------------------- ------------------------------------------------------------ ---------------------------------------------------------EID DSVATIASANNTSNSSQDNSDDFVLVPNNLP-VDPC-SGNYDKSKPTRVPQTASNAQ--- ---------------------------------------------------------ASP PRPSSL----------------PISEPKPVPTSARKISRQQSQTPP-------------- ---------------------------KNIP----------------------------- -----NAIP--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RSQPISMK------------------------- ---------------------RSEHRNS--NCDISSISPPAVQFAIGTPPTGSRRRSTSG GSLSETPP--PPSCWT--------------------VSPASHHSPLR------------- ---------------------------------------------RSGTSSPVL------ -----------------------------------------------------SNALSKL PALGSPTLLT------------------N----DNNNT------------------HPLG SRAFT-----------L--PEMGPTAGLGSYLHDTNMD-DHPINFHAPELPAETLMD--R EHNETVAKLNFV--IALTDCILEVANSRCEPLSALM-----------SADAQPIAPHAPE HCKRAERLVLLVRALNLLSSGMHLASSNLQSGQLKPS--DT------------------- -VKN-VLSMMHTRYRSTLCESKKLN----------------GAGLL-QRAGASNITADKI LYDHAIRMCQTAALDELFGNPEDCF-SRYQSAQILLHSLAQKCS---------------- ------------------------------------------------------------ ------------------------------------------------H--PKDKELLS- -TYKDAVEKRLYILQQQGYIYERS------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >C_elegans_Y60A3A.1.1 ---------------------------------------------M-EQ----------- ---FDGFEYSKRDLLGHGAFAIVYRGRYVDRTDVPVAIKAIAKKNISKSK--NLLTKEIK ILKELSSLKHENLVGLLKCTETPTHVYLVME--FCNGGDLADYLQQKTTLNEDT------ ------------------IQHFVVQIAHALEAINKKGIVHRDLKPQNILLCNNSRTQNPH -----------FTDIVIK----L-----ADFGFARFLNDGV-MAATLCGSPMYMAPEVIM SMQYD-AKADLWSIGTILFQCLTGKAPF-VAQ-TPPQLKAYYEKTRELRPNIPE--WCSP NLRDLLLRLLKRNAKDRISF--EDFFNHPFLTS------------PLLPSPSKRILESAR SPLLA-NRRIITPQ---SS---------LPVPKRA--GSTKLDSPTPVRRIGESP--RVQ RRVITPGMPSPVPGAPMQESTDFTFLPPRQE----------------------SSPVKQV QV-------------------------------------------------------HTN VSPSL-----------------TTCKPVPVPSQRLTYQKMEERLAA-------------- --ARKTAVP---------------SSSSPTGSAVSAQHQ--------------------- HQHQQQQEP--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ASSPVVQRIERPDQLPRRTTLQDPNAHDIERM- -------------------TMPNPTFVVCGSST-------KPSPNNANRVRRSTITSPAD TQDMVAADQMLSNLDPTTTTTT--------------IPKSATTANIQGIPRGARD----- ---------------------------------------------RSVTSPPQPTIH--- --------------------ENEPLD---------------------------NAKYQQT DVNNSPTAPTEPFIIK----NQTTCSTSS----TSSSV-------------------VEE EEAMS--------------LPFASGSHLAAGFKKTPAEVPMDHGALPPALDQEIVLG--E EHKQILAKLRFV--AELVDTLIHVAEQKDNPL------ASAMASRRQLLTTGTSTTNTSS PYRRAEQLVVYVRALHMLSSALLLAQTNVANRVLHPS--VA------------------- -VQQ-VLNQLNDKYHQCLVRSQELA----------------SLGLPGQDPAMAVISAERI MYRHAIELCQAAALDELFGNPQLCS-QRYQTAYMMLHTLAEQVN---------------- ------------------------------------------------------------ ------------------------------------------------C--DQDKTVLT- -RYKVAVEKRLRILERQGFVAAVNT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >D_rerio_ENSDARP00000083843 ---------------------------------------------M-ET----------- ---VGDFEYSRKDLIGHGAFAVVFKGRHKKKTDWEVAIKSINKKNLSKSQ--ILLGKEIK ILKE---LQHENIVALYDVQETPSSVFLVME--YCNGGDLADYLQAKGTLREDT------ ------------------LRVFLQQIAAAMRILNSKGIIHRDLKPQNILLSYTGRKK-SS -----------INGIRIK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIM SQNYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNKSLVPNIPR--ETSP QLEDLLLGLLQRNQKDRIDF--DTFFSHPFLEPISTIKKS-----CPVPVPSCSGLVSDS TCGSSPSCRYVSPP---SL---------PDM-QTL--PEDVLSSPP----LGPPN--YLQ -LSKESGGSTSSKN-SSCDTDDFVLVPH-LS-GEQSYDL--------PMGAVGRRPSSEF LLCGGN-------------------------------------------------CHTPM VSPR------------------SETTPIPVPTQVRNYQRIKQNLSS-------------S PTTTLYGSP--R-----SGTVRR-SNTSPMGFPKMVSASPSP--ADTVQT-VGRRLSTG- SSRPYSPSPL-------------------------------------------------- -----------------VGTIPEQLGHCCCGHPQSHEPR--------------------- ----------------------------------------------------SRSS---- SG---G------------------------------------------------------ ---------------------------SPVPSSQ-----L--L-GARLQSAPTLTDIYQ- -SKQKLHKQLS--------DPVHPTSSAYPS--NHSPQLGRP-ANLGTSPTKHLGSSPRT SDWLTKSP--LPTIIGSPTK-VTAPFK---------IPKTQASCNLMALADSPIPN---- ---KTLM----DGRELCAHHCTAYPSSRQPAP-EA--SKTSFG--RSVSAGRLSEPP-VR ITLGG--QPY-QGSTDSLNTER-PMDT-------APAGMCALA------AGG-GSPRTVV FTVGSPPSSSTPPTCSHLASRPRATSVGS----NSSAGSLCSTSG---KVYMGSPP-GMT IGSSP----------PG--AEAGPSSLRYVPYGTSPPSLDGFITFEAPELPEETLME--R EHTDTLMYLRMM--LSFTDCVLEIAALRAGGP--DLGASAASLYPPQDSVVVDQISQLSR EWGQVEQLVLYMKAAQLLASSLHLAKAQIKSAKLNPS--TA------------------- -VKQ-VVKSLNERYKSCISLCRRLTDKLNH-------FFSDKQRFV---DEINSVTAEKL IYNHAVEMVQSAALDEMFQQTEDIA-YRYNKASMLLEGLTKILQ---------------- ------------------------------------------------------------ ------------------------------------------------D--PADIENVI- -KYKASVDRRISALCYCTVTL--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >R_norvegicus_ENSRNOP00000003792 ---------------------------------------------M-EV----------- ---VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQ--ILLGKEIK ILKE---LQHENIVALYDVQELPNSVFLVME--YCNGGDLADYLQAKGTLSEDT------ ------------------IRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYASRRK-SN -----------VSGIRIK----I-----ADFGFARYLHSNT-MAATLCGSPMYMAPEVIM SQHYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNRSLMPSIPR--ETSP YLANLLLGLLQRNQKDRMDF--EAFFSHPFLEQVP-VRKS-----CPVPVPVYSGPGPGS SCSSSPPCRFASPP---SL---------PDM-QHI--QEENLSSPP----LGPPN--YLQ -VSKDSA-SNSSKN-SSCDTDDFVLVPHNIS-SDHSYDM--------PMGTAGRRASNEF FVCGGQ----C----------------------------------------------QPT VSPH------------------SETAPIPVPTQVRNYQRIEQNLIS-----------TAS SGTNPHSSP--R-----SAVVRR-SNTSPMGFLRVGSCSPVP--ADTVQT-GGRRLSTG- SSRPYSPSPL-------------------------------------------------- -----------------VGTIPEQFSQCCCGHPQGHEAR--------------------- ----------------------------------------------------SRHS---- S----G------------------------------------------------------ ---------------------------SPVPQTQSPQSLL--L-GARLQSAPTLTDIYQ- -NKQKLRKQHS--------DPVCPSLAGAGY--SYSPQPSRP-GSLGTSPTKHMGSSPRS SDWFFKTP--LPTIIGSPTK-TTAPFK---------IPKTQASSNLLALVTRHGPAES-- Q-SKDGN----DPRQ-CSHCLLVQGSERHRSE-QQ--SKAVFG--RSVSTGKLSEQQHVK APLGG----H-QGSTDSLNTER-PMDV-------APAGACGVVLALPA-GTA-ASARAVL FTVGSPPHSATAPTCTHMVLRTRTTSVGS----NSSGGSLCSASG---RVCVGSPP-APG FGSSP----------PG--AEAAP-SLRYVPYGASPPSLEGLITFEAPELPEETLME--R EHTDTLRHLNMM--LMFTECVLDLTAVRGGNP--ELCTSAVSLYQIQESVVVDQISQLSK DWGRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPS--TA------------------- -VKQ-VVKNLNERYKFCITMCKKLTEKLNR-------FFSDKQRFI---DEINSVTAEKL IYNCAVEMVQSAALDEMFQQTEDIV-QRYHKAALLLEGLSKILQ---------------- ------------------------------------------------------------ ------------------------------------------------D--PADAESVH- -KYKCSIERRLSALCCSTAAV--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >P_troglodytes_ENSPTRP00000042372 ---------------------------------------------M-EV----------- ---VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQ--ILLGKEIK ILKE---LQHENIVALYDVQELPNSVFLVME--YCNGGDLADYLQAKGTLSEDT------ ------------------IRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRK-SS -----------VSGIRIK----I-----ADFGFARYLHSNM-MAATLCGSPMYMAPEVIM SQHYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNRSLMPSIPR--ETSP YLANLLLGLLQRNQKDRMDF--EAFFSHPFLEQGP-VKKS-----CPVPVPMYSGSVSGS SCGSSPSCRFASPP---SL---------PDM-QNI--QEENLSSSP----LGPPN--YLQ -VSKDSA-STSSKN-SSCDTDDFVLVPHNIS-SDHSYDM--------PMGTAGRRASNEL LVCGGQ----C----------------------------------------------QPT VSPH------------------SETAPIPVPTQIRNYQRIEQNLTS-----------TAS SGTNVHGSP--R-----SAVVRR-SNTSPMGFLRPGSCSPVP--ADTAQT-VGRRLSTG- SSRPYSPSPL-------------------------------------------------- -----------------VGTIPEQFSQCCCGHPQGHDSR--------------------- ----------------------------------------------------SRNS---- S----G------------------------------------------------------ ---------------------------FPVPQAQSPQSLL--S-GARLQSAPTLTDIYQ- -NKQKLRKQHS--------DPVCPSHTGAGY--SYSPQPSRP-GSLGTSPTKHLGSSPRS SDWFFKTP--LPTIIGSPTK-TTAPFK---------IPKTQASSNLLALVTRHGPAEE-- Q-SKDGN----EPRE-CAHCLLVQGSERQRAE-QQ--SKAVFG--RSVSTGKLSDQQ-GK TPICR----H-QGSTDSLNTER-PMDI-------APAGACGGVLAPPA-GTA-ASSKAVL FTVGSPPHSAAAPTCTHMFLRTRTTSVGP----SNSGGSLCAMSG---RVCVGSPP-GPG FGSSP----------PG--AEAAP-SLRYVPYGASPPSLEGLITFEAPELPEETLME--R EHTDTLRHLNVM--LMFTECVLDLTAMRGGNP--ELCTSAVSLYQIQESVVVDQISQLSK DWGRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPS--TA------------------- -VKQ-VVKNLNERYKFCITMCKKLTEKLNR-------FFSDKQRFI---DEINSVTAEKL IYNCAVEMVQSAALDEMFQQTEDIV-YRYHKAALLLEGLSKILQ---------------- ------------------------------------------------------------ ------------------------------------------------D--PADIENVH- -KYKCSIERRLSALCHSTATV--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >B_taurus_ENSBTAP00000029699 ---------------------------------------------M-EV----------- ---VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQ--ILLGKEIK ILKE---LQHENIVALYDVQELPNSVFLVME--YCNGGDLADYLQAKGTLSEDT------ ------------------IRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYASRKK-SS -----------VSGIRIK----I-----ADFGFARYLHSNM-MAATLCGSPMYMAPEVIM SQHYD-AKADLWSIGTVIYQCLVGKPPFQQAN-SPQDLRMFYEKNRNLMPSIPR--ETSP YLANLLLGLLQRNQKDRMDF--EAFFSHPFLEQVP-AKKS-----CPVPVPMYAGSASGG SYGSSPSCRFVSPP---SL---------PDM-QHI--QEENLSSPP----LGPPN--YLQ -VSKDSA-STSSKN-SSCDTDDFVLVPHNIS-SDHSYDM--------PMGTAGRRASNEF LVFGGQ----C----------------------------------------------QPS VSPH------------------STAAPIPVPTQVRNYQRIEQNLTS-----------TAG SSTNLHGSP--R-----SAVVRR-SNTSPLGFLRPGSCSPAP--ADAVPA-IGRRLSTG- SSRPYSPSPL-------------------------------------------------- -----------------VGTIPEQFRQCCCGHLQGHESR--------------------- ----------------------------------------------------SRNS---- S----G------------------------------------------------------ ---------------------------SPVPQAQSPQPVL--L-GARLQSAPTLTDIYQ- -NKQKLRKQHS--------DPVCPSQAGAGY--SCSPQPSRP-GSLGTSPTKHTGSSPRS SDWFFRTP--LPTIIGSPTK-TTAPFK---------IPKTQASSNLLTLATRHGPSEG-- Q-LKDGN----NPRK-CTHCVLVQGGERQKSE-HQ--VKAAFG---SLKLEDCSSAS-IS TIK----QPD-QTSSCSMPVETISQKA-------APAGACGVALAPAI-GAA-ASSRAVM FTVGSPPHRAAATTCTHTGLRIRTTSGGS----SGSGGSLCSIGG---RVCGGSPP-GLC SGSPP----------PG--AEAAP-SLRHVPCGASPPSLEGLVTFEAPELPEETLME--Q EHADTLRHLNSM--LLFTECVLDLTAVRGGSP--ELCASAVSVYQIQESAVVDQISQLSK DWGRVEQLVLYMKAAQLLAASLHLAKEQIKSGKLSPS--SG------------------- -VKQ-VVKNLNERYKFCISMCKKLTEKLNR-------FFSDKQRFI---DEINSVTAEKL IYNCAVEMVQAAALDEMFQQTEDIV-YRYHKAALLLEGLTKILQ---------------- ------------------------------------------------------------ ------------------------------------------------D--PADIENIH- -RYKSSIERRLSALCYSTSAL--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >M_musculus_ENSMUSP00000004920 ---------------------------------------------M-EV----------- ---VGDFEYCKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQ--ILLGKEIK ILKE---LQHENIVALYDVQELPNSVFLVME--YCNGGDLADYLQAKGTLSEDT------ ------------------IRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRK-SN -----------VSGIRIK----I-----ADFGFARYLHSNT-MAATLCGSPMYMAPEVIM SQHYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNRSLMPSIPR--ETSP YLANLLLGLLQRNQKDRMDF--EAFFSHPFLEQVP-VKKS-----CPVPVPVYSGPVPGS SCSSSPSCRFASPP---SL---------PDM-QHI--QEENLSSPP----LGPPN--YLQ -VSKDSA-SNSSKN-SSCDTDDFVLVPHNIS-SDHSYDM--------PMGTTARRASNEF FMCGGQ----C----------------------------------------------QPT VSPH------------------SETAPIPVPTQVRNYQRIEQNLIS-----------TAS SGTNPHGSP--R-----SAVVRR-SNTSPMGFLRVGSCSPVP--GDTVQT-GGRRLSTG- SSRPYSPSPL-------------------------------------------------- -----------------VGTIPEQFSQCCCGHPQGHEAR--------------------- ----------------------------------------------------SRHS---- S----G------------------------------------------------------ ---------------------------SPVPQTQAPQSLL--L-GARLQSAPTLTDIYQ- -NKQKLRKQHS--------DPVCPSHAGAGY--SYSPQPSRP-GSLGTSPTKHTGSSPRN SDWFFKTP--LPTIIGSPTK-TTAPFK---------IPKTQASSNLLALVTRHGPAES-- Q-SKDGN----DPRE-CSHCLSVQGSERHRSEQQQ--SKAVFG--RSVSTGKLSEQQ-VK APLGG----H-QGSTDSLNTER-PMDV-------APAGACGVMLALPA-GTA-ASARAVL FTVGSPPHSATAPTCTHMVLRTRTTSVGS----SSSGGSLCSASG---RVCVGSPP-GPG LGSSP----------PG--AEGAP-SLRYVPYGASPPSLEGLITFEAPELPEETLME--R EHTDTLRHLNMM--LMFTECVLDLTAVRGGNP--ELCTSAVSLYQIQESVVVDQISQLSK DWGRVEQLVLYMKAAQLLAASLHLAKAQVKSGKLSPS--MA------------------- -VKQ-VVKNLNERYKFCITMCKKLTEKLNR-------FFSDKQRFI---DEINSVTAEKL IYNCAVEMVQSAALDEMFQQTEDIV-YRYHKAALLLEGLSKILQ---------------- ------------------------------------------------------------ ------------------------------------------------D--PTDVENVH- -KYKCSIERRLSALCCSTATV--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >H_sapiens_ENSP00000354877 ---------------------------------------------M-EV----------- ---VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQ--ILLGKEIK ILKE---LQHENIVALYDVQELPNSVFLVME--YCNGGDLADYLQAKGTLSEDT------ ------------------IRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRK-SS -----------VSGIRIK----I-----ADFGFARYLHSNM-MAATLCGSPMYMAPEVIM SQHYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNRSLMPSIPR--ETSP YLANLLLGLLQRNQKDRMDF--EAFFSHPFLEQGP-VKKS-----CPVPVPMYSGSVSGS SCGSSPSCRFASPP---SL---------PDM-QHI--QEENLSSPP----LGPPN--YLQ -VSKDSA-STSSKN-SSCDTDDFVLVPHNIS-SDHSCDM--------PVGTAGRRASNEF LVCGGQ----C----------------------------------------------QPT VSPH------------------SETAPIPVPTQIRNYQRIEQNLTS-----------TAS SGTNVHGSP--R-----SAVVRR-SNTSPMGFLRPGSCSPVP--ADTAQT-VGRRLSTG- SSRPYSPSPL-------------------------------------------------- -----------------VGTIPEQFSQCCCGHPQGHDSR--------------------- ----------------------------------------------------SRNS---- S----G------------------------------------------------------ ---------------------------SPVPQAQSPQSLL--S-GARLQSAPTLTDIYQ- -NKQKLRKQHS--------DPVCPSHTGAGY--SYSPQPSRP-GSLGTSPTKHLGSSPRS SDWFFKTP--LPTIIGSPTK-TTAPFK---------IPKTQASSNLLALVTRHGPAEE-- Q-SKDGN----EPRE-CAHCLLVQGSERQRAE-QQ--SKAVFG--RSVSTGKLSDQQ-GK TPICR----H-QGSTDSLNTER-PMDI-------APAGACGGVLAPPA-GTA-ASSKAVL FTVGSPPHSAAAPTCTHMFLRTRTTSVGP----SNSGGSLCAMSG---RVCVGSPP-GPG FGSSP----------PG--AEAAP-SLRYVPYGASPPSLEGLITFEAPELPEETLME--R EHTDTLRHLNVM--LMFTECVLDLTAMRGGNP--ELCTSAVSLYQIQESVVVDQISQLSK DWGRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPS--TA------------------- -VKQ-VVKNLNERYKFCITMCKKLTEKLNR-------FFSDKQRFI---DEINSVTAEKL IYNCAVEMVQSAALDEMFQQTEDIV-YRYHKAALLLEGLSRILQ---------------- ------------------------------------------------------------ ------------------------------------------------D--PADIENVH- -KYKCSIERRLSALCHSTATV--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >O_latipes_ENSORLP00000018791 --------------------------------------ERPTFGPM-EA----------- ---VGDFEYSRKDLVGHGAFAVVFKGRHRKKTDWEVAIKSINKKNLTKSQ--ILLGKEIK ILKE---LQHENIVGLYDVQETPNSVFLVME--YCNGGDLADYLQAKGTLREDT------ ------------------MRVFLQQIAAAMRVLNSKGIIHRDLKPQNILLSYSARKR-SN -----------VSSIRVK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIM SQNYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRLFYEKNKNLQPIIPR--ETSP QLTDLLLGLLQRNQKDRMDF--DTFFSHPFLESSSTIKKS-----CPVPVPSTSAAVTDS SCGSSPCIRYSSPPDTQSL---------PDM-QTL--AEDGLSSPP----LGPPN--FLQ -LSKESAGSTSSKN-SSCDTDDFVLVPH-IA-AD-SYDL--------PV-LLGRRPSNEF LMCGGG----TLLVGAQCLHGGSAPFSSPSGSAFVPQP---------------PQGQTAM VSPR------------------AETTPIPVPTQVRNYQRIKQNLSS-------------S PTSTLFSSP--R-----SGTVRR-SNTSPMGFPKVGSGSPSA--GDTPQT-VGRRLSTG- SSRPYSPSPLGIR----------------------------------------------- --------------FFPVGTIPEQLGHCCC-HLQNQEPR--------------------- ----------------------------------------------------SSSGEPSP SS---G------------------------------------------------------ ---------------------------SPIPPSQ-----L--L-GARLQSAPTLTEVYQ- -TRQKLHKQLS--------DPVQPSSS---C--SHSPQFGRP-ANLGSSPTKLLGTSPRT SDWLQKSP--LPTIIGSPTKPMSAPFK---------IPKTQASCNLMALVDSPAST---- ---KMLL----EARGLCSHHSNPYLAGRPAAP-EC--SRT-FG--RSVSTGRLSEQP-IR ITLGG--QPS-EGSTDSLNTER-PMDTGTAAGRLSPCRPNMLLQ-----GGS-ASPRTVV FTVGSPPSSSTPPTCSHLGTRPRTTSVGS----NSSAGSLCSTSG---RLHVGSPP-GMA IGTSP----------PG--SFD----------GTSPPSLEGFITFEAPELPEETLME--R EHTDTLMYLRMM--LSFTDCILEMAALRAGGP--DLGISVASLYPPQDSVVVDQISQLSK EWGQVEQLVLYMKAAQLLASSLHLAKAQIKSAKLNPS--SA------------------- -VKQ-VVKSLNERYKSCISLCRQLTDKLNY-------FFSDKQRFV---DEINSVTAEKL IYNHAVEMVQSAALDEMFKQTEDIA-YRYSKASMLLDGLSKILQ---------------- ------------------------------------------------------------ ------------------------------------------------D--PTDVENVM- -KYKASVDRRISTLCYCTVTLYE------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >T_nigroviridis_ENSTNIP00000017404 --------------------------------------LDHHPIAM-ET----------- ---VGDFEYSRKDLVGHGAFAVVFKGRHRKKTDWEVAIKSINKKNLSKSQ--ILLGKEIK ILKE---LQHENIVGLYDVQETPNSVFLVME--YCNGGDLADYLQAKGTLREDT------ ------------------LRVFLQQIAAAMRILNSKGIIHRDLKPQNILLSYAGRKK-SN -----------ISGIRIK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIM SQNYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNKNLQPIIPS--ETSP QLRDLLLGLLQRNQKDRMDF--DTFFSHPFLEPSSTIKKS-----CPVPVPSTSNTATDS SCGSSPCIRYSSPP---SL---------PDM-QTL--AEDGLSSPP----LGPPN--FLQ -LSKESAGSSSSKN-SSCDTDDFVLVPH-IS-ADSSNLL----------------PPPCP HLCSTC----SPLPPLTVPAAGFTPRLLASCNFQQPQP---------------VSGQTPM VSPR------------------AETTPIPVPTQIRNYQRIKQNLSS-------------S PTTALYSSP--R-----SGTVRR-SNTSPMGFPK-----------NVPQT-IGRRLSTG- SSRPYSPSPLGLF----------------------------------------------- --------------VSPVGTIPEQLGHCCC-HLQNHESR--------------------- ----------------------------------------------------SRSS---- SGAFPG------------------------------------------------------ ---------------------------SPVPSSQ-----L--L-GARLQSAPTLTEFYQ- -SRQKLHKQLS--------DPTQPSSSL--C--SHSPQLGRP-ANLGSSPTKHLGSSPRT SEWLQKSP--LPTIIGSPTKTISAPFK---------IPKTQASCNLMALADSPMPT---- ---RTLA----DARDVCAHHCSPYHTGRPAAP-EG--SRT-FG--RSVSTGRLSEQP-IR ITLGG--QAY-QGSTDSLNTER-PMDTAPQ----APAGPGVQPQ-----GGS-ASPRTVL FTVGSPPKSSTPPR----STSTLLFSVGS----NSSAGSLCSTSG------------GFL GGQMM----------PG--VDGAPSSLRYVPYGTSPPSLEGFITFEAPELPEETLME--R EHTDTLMHLRMM--LSFTDCVLEMAAVRAGGT--ELGVSAASLYPPQESVVVDQISQLSK EWGQVEQLVLYMKAAQLLASSLHLAKAQIKSAKLNPS--TA------------------- -VKQ-VVKNLNERYKSCISLCRQLTDKLNH-------FFSDKQRFV---DEINSVTAEKL IYNHAVEMVQSAALDEMFKQTEDIA-YRYSKASMLLDGLSKILQ---------------- ------------------------------------------------------------ ------------------------------------------------D--PTDVENVV- -KYKASVDRRISALCYCTVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >T_nigroviridis_ENSTNIP00000008902 -------------------------------------SEVGHGHKM-ET----------- ---VGKFEFSRKELVGHGAFAVVFKGRHREKHDWEVAVKCINKKNLAKSQ--TLLGKEIR ILKE---LKHDNIVALLDFQETVSSVFLVME--YCNGGDLADYLHSKGTLSEDT------ ------------------IRVFLQQIAGAMRVLQSKGIIHRDLKPQNILLSHLPGRK-SH -----------CNNTCIK----I-----ADFGFARYLQNNM-MAATLCGSPMYMAPEVIM SQNYD-AKADLWSIGTIVFQCLTGKAPF-QAS-SPQDLRLFYEKNKSLSPDIPR--ETSH HLRHLLLGLLQRNHTERMDF--DQFFSHPFLETSSSIKRV----VPAVSTMCPPGSPSAS SCSSSSTSHLASPPN--SL---------AEG-QQL----RVRTSAN----QEMDG--LLL -KDSS---GGGSRAWSSCDLEDFVMVPAHFSTADATAD-----------------GLHDS LLTSG-----SLLACAAVSCQSKSQAGSSSS--------------------------CSS PGPIRDRL--------GDVLQAGPSLPIPVPSQQQNFQRLEQNLLS-------------- --ARPDASP--R----LWSPMRRCSSGNLQGLAGAPEASPCC----QEKVAANRRLSLG- GARTVPPSSQ-------------------------------------------------- -----------------RRYVNSAPLWF-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PTAPECLLLQPGG--L-GTRLHSAPCLLEYTAA GARQKIRKQHS--------DPAVR-------------------PSPGAMTVCPLHCSPRL SELMQRSP--LPTILGSPSR-AVPPFE---------FPKPPSPPNLFTVLT-QGLVLGSP G-NRSNPVDPPGSQ--VNHYSHP------RRR-GD--QVQGFG--RSQSAGRLSDML-LK AAFGP-APSDTPTSCPNLQHFD-VL---------SPVAPPSGGTSP---TAGCSSPAGVV FTVGSPPSGSNPPLAS----RHRKSS-GS----FASISPAGSVSG---R--------PLQ VG-----------------CDAPS-SPRYSCSDPFAPNMGVGVMFEAPELPEETLME--Q EHTDTVHSLRFM--LDFAHCLVEVAGARGAGV--PEQDAPQASRVQQQSLVADQISSLSR EWSHAEQLVLYLKSAELLSGALHTAMERVRQGKLYPS--AT------------------- -VKQ-VVRKLNELYKSSVASCRSLSTRLER-------FFSRKHRLM---DQISSITAERL LFSHAVQMVQAAALDEMFHHGEASA-LRYHKALLLMEGLTLLLN---------------- ------------------------------------------------------------ ------------------------------------------------E--RDDIMSIS- -RCKECIERRLTALQSGLCV---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >M_domestica_ENSMODP00000005348 -----------------------------------------GTPSM-EV----------- ---VGDFEYSKKDLVGHGAFAVVFKGRHRKKTDWEVAIKSINKKNLSKSQ--ILLGKEIK ILKE---LQHENIVALYDVQELPNSVFLVME--YCNGGDLADYLQAKGTLSEDT------ ------------------IRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYASRRK-SS -----------VSGIRIK----I-----ADFGFARYLHSNM-MAATLCGSPMYMAPEVIM SQHYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNRSLIPSIPR--ETSP YLANLLLGLLQRNQKDRMDF--EAFFSHPFLEQVP-VKKS-----CPVPVPIYAGSVSGS SCGSSPSCRFASPP---SL---------PDM-QHI--QEDNLSSPP----LGPPN--YLQ -VSKDSA-STSSKN-SSCDTDDFVLVPHNIS-SDHSCDKVSLVPPPPPPVFCERGALSDQ LFFQNHGCRPC----------------------------------------------QPS PSPH------------------SETAPIPVPTQLRNYQRIEQNLTS------------AS PGTNPHGSP--R-----SAVVRR-SNTSPLGFLKMGSCSPVP--ADTVQP-AGRRLSTG- SSRPYSPSPL-------------------------------------------------- -----------------VGTIPEQLGHCCCGQPQGHDSR--------------------- ----------------------------------------------------SRNS---- S----------------------------------------------------------- -----------------------------VPQSQSPQSLL--M-GARLQSAPTLTDIYQ- -NKQKLRKQHS--------DPVCPSQAGFGY--SYSPQPSRP-VSLGTSPTKHMGSSPRS SDWLFKTP--LPTIIGSPTK--VAPSK---------IPKTQASSNLLALVTRQGPTDV-- Q-AKDVS----DPRE-FSHFLSAQGSEKQMAE-QH--GKAPFG--RSVSTGKLSDQQ-VK TPLGG--QLY-QGSTDSLNTER-PMDT-------APAGTCGIVLGPPG-VTG-ASSRAVM FTVGSPPNSATPPTCTQMVLRTRTTSVGS----NSSGGSLCSTSG---RIYMGSPP-GIY MGSSP----------PG--AEAAP-SLKYTPYGTSPPSLEGFITFEAPELPEETLME--R EHTDTLRHLNTM--LTFTECVLDLTAIRGGNP--ELCTSAVSLYQIQESVVVDQISQLSK DWGQVEQLVLYMKAAQLLASSLHLAKAQIKSGKLNPS--TA------------------- -VKQ-VVKNLNERYKFCIAMCKKLTEKLNR-------FFSDKQRFI---DEINSVTAEKL IYNCAVEMVQSAALDEMFQQTEDIV-YRYHKAALLLEGLTKILQ---------------- ------------------------------------------------------------ ------------------------------------------------D--PADIENVHK CKYKSSIERRLSALCYGAVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >T_guttata_ENSTGUP00000007355 ------------------------------------------------------------ ------FEYSKKDLIGHGAFAVVFKGRHRKKTDWEVAIKSINKKNLSKSQ--ILLGKEIK ILKE---LQHENIVALYDVQEMPNSVFLVME--YCNGGDLADYLQAKGTLSEDT------ ------------------IRVFLQQIAAAMRILHSKGIIHRDLKPQNILLSYASRRK-SS -----------VSGIRIK----I-----ADFGFARYLHSNM-MAATLCGSPMYMAPEVIM SQHYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNRNLIPSIPR--ETSA YLADLLLGLLQRNQKDRMDF--EAFFNHPFLDHVSTVKKS-----CPVPVPTYPGSVSGS SCGSSP-CRFASPP---SL---------PDM-QHI--QEENLSSPP----LGPPN--YLQ -VSKDSA-STSSKN-SSCDTDDFVLVPHNIS-SDHSYDM--------PLGAAGRRASSEF LMCGGH----C----------------------------------------------QPS VSPR------------------SETAPIPVPTQLRNYQRIEQNLSS-----------TAS PVSNPHGSP--R-----AGVVRR-SNTSPMGFMKMGSCSPVP--ADTAQG-VGRRLSTG- SSRPYSPSPL-------------------------------------------------- -----------------VGTIPEQLGHCCCGQLQGHESR--------------------- ----------------------------------------------------SRNF---- S----G------------------------------------------------------ ---------------------------SPIPPSQSPQSLL--M-GARLQSAPTLTDIYQ- -NKQKLRKQHS--------DPVCPSYAGYGY--SHSPQPSRP-GSLGTSPTKHMGSSPRS SDWLFKTP--LPTIIGSPTK-ATAPFK---------IPKTQASSNLLALANRQGLAETLL Q-PKDIT----DPRD-FTHFHSSQAADKQA-E-QH--SKTTFG--RSVSTGKLSDQQ-VK TTLGG--QLY-QGSTDSLNTER-PMDT-------APAGAYGIAMATPSMASGAASSRAVM FTVGSPPSSATPPTCTHMVLRTRTTSVGS----NSSGGSLCSTSG---RVYMGSPP-GIY MGSSP----------PG--AEAAP-SLKYIPYGTSPPSLEGFITFEAPELPEETLME--R EHTDTLRHLNMM--LTFTECVLDLTAVRGGNP--DLCTSAVSLYQIQESIVVDQISQLSK EWGQVEQLVLYMKAAQLLASSLHLAKAQVKSGKLNPS--TA------------------- -VKQ-VVKSLNERYKFCIGMCKKLTEKLNR-------FFSDKQRFI---DEINSVTAEKL IYNCAVEMVQSAALDEMFQQTEDIT-YRYHKAALLLEGLTKILQ---------------- ------------------------------------------------------------ ------------------------------------------------D--PADIENVH- -KYKSSIERRLSALCYSTVAVYEQ------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >T_rubripes_ENSTRUP00000015470 --------------------------------------LDHHPVAM-ET----------- ---VGDFEYSRKDLVGHGAFAVVFKGRHRKKTDWEVAIKSINKKNLSKSQ--ILLGKEIK ILKE---LQHENIVGLYDVQETPNSVFLVME--YCNGGDLADYLQAKGTLREDT------ ------------------LRVFLQQIAAAMRILNSKGIIHRDLKPQNILLSYAGRKK-SN -----------ISGIRIK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIM SQNYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNKNLQPIIPS--ETSP QLRDLLLGLLQRNQKDRMDF--DTFFSHPFLEPSSAIKKS-----CPVPVPSTSNTATDS SCGSSPCIRYNSPP---SL---------PDM-QTL--AEDGLSSPP----LGPPN--FLQ -LSKESAGSTSSKN-SSCDTDDFVLVPH-IS-AD-SYDQ--------PMG-VGRRPSSEF LMCGGL---------------------GTSAVFSESHPCFPSQLPALSGGKHQSGRKTPM VSPR------------------AETTPIPVPTQIRNYQRIKQNLSS-------------S PTTTLYSSPSLR-----AGTVRR-SNTSPMGFPKVGSGSPNS--ADVPQT-IGRRLSIG- SSRPYSPSPLGLF----------------------------------------------- --------------VSSVGTIPEQTSYNLLHSSQGDHCH--------------------- ----------------------------------------------------GPLP---- SP---G------------------------------------------------------ ---------------------------SPFPSSQ-----L--L-GARLQSAPTLTEFYQ- -TRQKLHKQLS--------DPIQPSSSL--C--SHSPQLGRP-ANLGSSPTKLLGSSPRT SEWLQKSP--LPTIIGSPTKIISAPFK---------IPKTQASCNLMALADSPMPT---- ---RTLA----DARDVCAHHCSPYHTGRPAAP-EG--SRT-FG--RSVSTGRLSEQP-IR ITLGG--QAY-QGSTDSLNTER-PMDT-------APAGPSVQHQ-----CGS-ASPRTVL FTVGSPPKSSTPPTCSHLGTRPRTTSVGS----NSSAGSLCSTSG---RVQMC------- ---------------PG--VEGAPSSLRYVPYGTSPPSLEGFITFEAPELPEETLMEEQR EHTDTLMHLRMM--LSFTDCVLEMAAVRAGGT--ELGVSAASLYPPQDSVVVDQISQLSK EWGQVEQLVLYMKAAQLLASSLHLAKAQIKSAKLNPS--TA------------------- -VKQ-VVKNLNERYKSCISLCRQLTDKLNH-------FFSDKQRFV---DEINSVTAEKL IYNHAVEMVQSAALDEMFKQTEDIA-YRYSKASMLLDGLSKILQ---------------- ------------------------------------------------------------ ------------------------------------------------D--PTDVENVV- -KYKASVDRRISALCYCTVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >O_anatinus_ENSOANP00000021856 ------------------------------------------SGPM-ET----------- ---VGKFEFSRKDLIGHGAFAVVFKGRHQEKHDLEVAVKCINKKNLAKSQ--TLLGKEIK ILKE---LKHENIVALYDFQEMANSVYLVME--YCNGGDLADYLHSMRTLSEDT------ ------------------IRIFLQQIAGAMKMLHSKGIIHRDLKPQNILLSYPGARK-SN -----------PNNIRVK----I-----ADFGFARYLQNNM-MAATLCGSPMYMAPEVIM SQHYD-AKADLWSIGTIIYQCLTGKAPF-QAS-SPQDLRLFYEKNKTLMPNIPR--ETSG HLRQLLLGLLQRNHKDRMDF--DEFFHHPFLDASSSIKKS-----PPVPMPSYPSSGSGS SSSSSSTSHLASPP---SL---------GEM-QQ---LQKTLTSPN----QDTTG--FLH -RSKDSA-GSSSKN-SSCDTDDFVMVPAQFP-SDIAAE------------AAGGKPVQDS LMYSGS----SLVTSAGLESQGQTPSPSPPY--------------------------GNS PSPSGRPGPFSGSKY-------GPSIPIPVPTQIQNYKRIEQNLQS-------------- --PIQYTPP--R--LRRQTAEQNKTRQKPLPFLPHAPSPPKPSSGLTGRARSDQPIRRS- PCRPVLGQTQ-------------------------------------------------- -----------------VGTIPERPGQSLIPSPQGAELR--------------------- ----------------------------------------------------AWLP---- IP---G------------------------------------------------------ ---------------------------ASLPE-PSTR--G--L-GSRLHSAPNLSDLHV- -VRPKLPKPPS--------EPLVAACG--------HAQASPP---HGLQACRPLRSSPKL SEFMQRNP--LPTIVGSPTK-VMRPYSVIPMGLPAPVPARSCSHGQGPLLGYLQIVVTPT R-NRTLP----DLKE-MGHFQGQHPGLGFRPV-EE--IKGPFGRSRSLSTGRLTDLL-LK AAFGA--QVSEAGSNDSLNNEK-PMEIT------GPSAGYGGNLFSGARAGGSSSPSPVV FTVGSPPSGTTPPQAP----RTRMFSVGS----SGSPSSGTSFS----R--------HML LGTGA----------EA--PEAPS-SLRCTFTDPITANLEGAVTFEAPELPEETLME--Q EHTDILRSLRFT--LAFVHSVMEIAAVKGSAG--ELGSSVASEYQLQESVVADQISLLSR EWSYAEQLVLYLKVAELLSSGLQTAIEQIKAGKLCLS--ST------------------- -VKQ-VVRKLNELYKSSVSACHCLNVRLQR-------FFLDKQKLM---DRINSITAEKL IFSSAVQMVQSAALDEMFHHREDCV-QRYHKALLLMEGLLPIIT---------------- ------------------------------------------------------------ ------------------------------------------------E--QTDIENIN- -KCKMCIERRLSALLSGICA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >G_gallus_ENSGALP00000007513 ------------------------------------------------------------ -----TFEYSKKDLIGHGAFAVVFKGRHRKKTDWEVAIKSINKKNLSKSQ--ILLGKEIK ILKE---LQHENIVALYDVQEMPSSVFLVME--YCNGGDLADYLQAKGTLSEDT------ ------------------IRVFLQQIAAAMRILHSKGIIHRDLKPQNILLSYASRRK-SS -----------VSGIRIK----I-----ADFGFARYLHSNM-MAATLCGSPMYMAPEVIM SQHYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNRNLIPSIPR--ETST YLADLLLGLLQRNQKDRMDF--EAFFNHPFLDQISTVKKS-----CPVPVPTYAGSVSGS SCGSSPSCRFASPP---SL---------PDM-QHI--QEENLSSPP----LGPPN--YLQ -VSKDSA-STSSKN-SSCDTDDFVLVPHNIS-SDHSYDM--------PLGAAGRRASSEF LMCGGH----C----------------------------------------------QPS VSPR------------------SETAPIPVPTQLRNYQRIEQNLSS-----------TAS PVSNPHGSP--R-----AGVVRR-SNTSPMGFMKMGSCSPIP--GDTAQG-VGRRLSTG- SSRPYSPSPL-------------------------------------------------- -----------------VGTIPEQLGHCCCGQLQGHESR--------------------- ----------------------------------------------------SRNF---- A----G------------------------------------------------------ ---------------------------SPIPPSQSPQSLL--M-GARLQSAPTLTDIYQ- -NKQKLRKQHS--------DPVCPSYAGYGY--SHSPQPSRP-GSLGTSPTKHMGSSPRS SDWLFKTP--LPTIIGSPTK-ATTPFK---------IPKTQASSNLLALANRQGSIDAPL Q-PKDIT----EPRD-FSHFHSTQGSEKHAGE-QH--SKATFG--RSVSTGKLSDQQ-VK TTLGG--QLY-QGSTDSLNTER-PMDT-------APAGAYGIAVAPPSMGSG-ASSRAVM FTVGSPPSSATPPTCTHMVLRTRTTSVGS----NSSGGSLCSTSG---RVYMGSPP-GIY MGSSP----------PG--AEAAP-SLKYMPYGTSPPSLEGFITFEAPELPEETLME--R EHTDTLRHLNMM--LTFTECVLDLTALRGGNP--DLCTSAVSLYQIQESIVVDQISQLSK EWGQVEQLVLYMKAAQLLASSLHLAKAQVKLGKLNPS--TA------------------- -VKH-VVKSLNERYKFCIGMCKKLTEKLNR-------FFSDKQRFI---DEINSVTAEKL IYSCAVEMVQSAALDEMFQQTEDIT-YRYHKAALLLEGLTKILQ---------------- ------------------------------------------------------------ ------------------------------------------------D--PADIENVH- -KYKSSIERRLSALCCSTVAVYEQ------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >G_gallus_ENSGALP00000003776 ---------------------ASSALSAASRPRSCPGRGPPARSAM-ET----------- ---VGKFEFSRKDLIGHGAFAVVFKGRHKEKPELEVAVKCINKKNLAKSQ--TLLGKEIK ILKE---LKHENIVALYDFQEVANSVYLVME--YCNGGDLADYLHTMRTLSEDT------ ------------------IRLFLQQIAGAMKMLHSKGIIHRDLKPQNILLSYSGGRK-SN -----------PNNIRIK----I-----ADFGFARYLQNNM-MAATLCGSPMYMAPEVIM SQHYD-AKADLWSIGTIIYQCLTGKAPF-QAS-SPQDLRLFYEKNKILMPNIPR--ETSS HLRQLLLGLLQRNHKDRMDF--DEFFHHPFLDASASMKKS-----ASVPMPSYPSSGSGS SSSSSSTSHLASPP---SL---------GEMQQQL--QEKALASPT----QDSPG--FLH -GSKDSA-GSSSKN-SSCDTDDFVMVPAQFS-SEMTAE------------AAGGKPIQDS LMYSGS----SLVTSAGLESQGRTPSPSPPY--------------------------SSS PSPSSRPGQFSSSKY-------GHSVPIPVPTQIHNYRRIEQNLQS-------------- --PHQYASP--R-----SGTVRRSSSTSPLGFPKTGASPPYP--GEHGSVPSSRKLSFG- GAKPFTPSPQVK------------------------------------------------ -----------------VGTIPEQPIQTVIPSSLGAEVR--------------------- ----------------------------------------------------SRIP---- AA---G------------------------------------------------------ ---------------------------ASAPE-HSPR--G--M-GSRLHSAPNLSDLHS- -CRQKITKQHS--------DPLVAHFV--------HTPVSQPLQIHGLQHCRQLRSSPKL SEFMQRSP--LPTIMGSPTK-AVSPFE---------FPKTSSSQNLLTLLAHQGVMMTPT R-NKTLP----DLKE-MGHFHCQQTGLGLRPV-EE--IKG-----RSLSTGRLTDLL-LK AAFGA--QISEAGSNDSLNNEK-PMEIA------APSGAYGGTLHSGARAGGSASPSPVI FTVGSPPSGTTPPQTT----RTRMFSVGS----SSSLSSGGSFTG---R--------HLA VGTGG----------DA--LEGPS-SLRYAFADPITANLEGAVTFEAPELPEETLME--Q EHTDILRSLRFT--LAFVHYVMEIAALKGSSS--EMSGSVASEYQLQESVVADQISLLSR EWSYAEQLVLYLKVAELLSSGLQTAIEQIKAGKLCLS--ST------------------- -VKQ-VVKKLNELYKSSVSSCHCLNMRLQR-------FFLDKQKLM---DQINSITAEKL IFSYAVQMVQSAALDEMFHHREDCA-QRYHKALLLMEGLLNIIT---------------- ------------------------------------------------------------ ------------------------------------------------E--QGDIENIN- -KCKLCIERRLSALLSGFCA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >G_aculeatus_ENSGACP00000016289 ---------------------------------------------M-ET----------- ---VGKFEFNRKDLIGHGAFAVVFKGRHKEKRDWVVAVKCINKKNLAKSQ--SLLGKEIK ILKE---LKHENIVRLLDYQEMGGCVYLVME--YCNGGDLAEYLHSKGTLREDT------ ------------------IRVFLQQIGQAMKVLQSKDILHRDLKPQNILLCHPEGRR-SS -----------PINTSIK----I-----ADFGFARHLQTNT-MAATLCGSPMYMAPEVIM SQNYD-AKADLWSIGTIVYQCLTGKAPF-HAS-TPQELRLFYESNRTLLPNIPK--ETSP NLRHLVLGLLQRNHKERFGF--DEFFHHPFLEASSSSKKC-----SPPAVISLPGSSSVS SSSGSSTSYLTSPQH--SD---------GEM-HQL--QPKAQYSPT----QNPHG--FLL -KEKA---NQDSKS-TSSYSEDYVMVQTQFP-SGCTCE------------LEVGSPIDSC LIYSGS----SPLAERCLRNAGKTPPPSPLL--------------------------HPR SKPISKPVAIVGRKC-------ISSAPIPVPTQIQNYQRMAQNLQS-------------- --VGLHGST--RYVQPLGCIISTPTSVSWVTLCCAGSSSPQQ-GGSPGFILDSLRLASV- GARPQQSSPLGRH--PDRLLFHSFRECFSSTALLQPLLRSHSDRIIGPFGGSLNIPPSLN IFSVPTFPSADLPYNTLAGMTPNTTEQTSPHGTRTGLL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AGFPDRKDTPSPKVGLQPVRCVDVCSFV----- --SPSIQPKSLLLCTFYVVQSRMPNRIRTVLDLQSLEPSPASQTNRSSKSLNKNGPFRRS E----------------------------------------------------------- ---------------------------------------------QSLSTGRLSDML-LK ATFGA--HLVGEDSDESLNSEK-SMDI-------TAPPTGRQRGFLYS-----DSPPPAI FTLGLQSRENTPPDTT----GPRIQSAGP----LVSAVDGSSVHV---LLLISGSPSRLL QGG----------------------SRRNSESEAMDSTQHSSLVFHPPDLPEETLME--Q AHTDELNELRFT--LAFVLCVTELASSKCSMP--EAVSSP-DVSFLEQSLVTDQISLLSR EWSYAEQLVLYMKAEEFLSSALHTAKETIKQGRLLPS--AT------------------- -VKQAVIRKLNELYKSCVTYCRTLNHRLQT-------FLLDKQKLM---DRFNGLTAEKL IYSHTVEMVQCAALDEMFHYGTASV-QRYHKALLLMEGLSRIIT---------------- ------------------------------------------------------------ ------------------------------------------------E--EKDIDSIE- -KCKQCIERRLSAL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >O_latipes_ENSORLP00000013892 --------------------------------------------DM-ET----------- ---VGKFEFSRKDLIGHGAFAVVFKGRHREKHDWEVAVKCINKKNLAKSQ--TLLGKEIK ILKE---LKHENIVALLDFQETVSSVYLVME--YCNGGDLADYLHSKGTLSEDT------ ------------------IRVFLQQIVGAIKVLQSKGIIHRDLKPQNILLSYPAGRK-SH -----------CNNICIK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIM SQNYD-ARADLWSVGTIVFQCLTGKAPF-QAS-SPQDLRLFYEKNKNLSPNIPR--ETSQ HLRHLLLGLLQRNHKERMDF--DEFFCHPFLEASSSVKKT----APTATMTCLPSSASAS SCSSSSTSHLASPP---SL---------AET-Q----RAKAVASPT----QEATG--FLL -KDSSGG-GGSSKNSSSCDTDDFVIVPAHFTTGELTCE---------------SKVLQDS LMNSDR----SLLASAGLSNQAKTPPHSPTY--------------------------SGS PSPI-RLTEFPGSNYGGNYGNQGESLPIPVPSQVQNYLRLEENLSS-------------- --TKQDGSP--R----LSTPVRRCSSGSVVGFTRPGPPPSCV----QGSSPTSRRLSLG- AARTLQLPP--------------------------------------------------- ------------------------GMYTFFVGLNGKEQRKGERWMLLMRGKECKIKASQQ QTES-------------------------------------------------------- ------------------------------------------------------------ ---------------------------RPIPQ-QSPQAAG--L-GSRLHSAPCLLECASG GSRHKIRKQLS--------DPVAP-------------------LSAGLLTGRPLHSSPRL SELMQRNP--LPTILGSPSK-AIPPFE---------FPKPPSSPNLMTLLTKQGMVIVPP C-SRTAPGELGDMQ--QAPSSGPRTAHCIHRL-SD--DNKRFG--RSQSAGGLSDML-LL AAFGAGGHAGDRGSTENLTAAK-AIEITEKALFPCPLGPPGGGF-----APGCSSAAQVV FTVGSPPSGSTPPLTS----RQRKCSGSS----FTSVSPACSFSA---R----------H TGTYA----------DG--FEAPP-SPRYNFADTVTANMGGPVTFEAPELPEETLME--Q EHTDMVQRLRFT--LEFTHCLMEVAGARGVAA-GPLGDLSHLSLLQQQSLVADQISSLSR EWSFAEQLVLYLKTTELLSAALHSAMDQVKQGRLYPS--AT------------------- -VKQ-ILKRLNELYKLSVASCRSLSTRLEH-------FFSRKHRLM---DRITSITAERL LFNHTVQMVQAAALDEMFHQGEASI-LRYHKALLLMEGLSLLLT---------------- ------------------------------------------------------------ ------------------------------------------------Q--QEDILSVS- -KCKECIERRLTTLQSGLCV---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >G_aculeatus_ENSGACP00000017889 ---------------------------------------------M-EP----------- ---VGDFEYSRKDLVGHGAFAVVFKGRHRKKTDWEVAIKSINKKNLSKSQ--ILLGKEIK ILKE---LQHENIVALYDVQETPNSVFLVME--YCNGGDLADYLQAKGTLREDT------ ------------------LRVFLQQIAAAMRILNSKGIIHRDLKPQNILLSYAGRKR-SN -----------ISGIRIK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIM SQNYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNKTLQPIIPR--ETSQ QLGHLLLGLLQRNQKDRMDF--DAFFSHPFLEPLSTIKKS-----CPVPVPSASNAVTDS SCGSSPSIRYNSPP---SL---------PDM-QTL--AEDGLSSPP----LGPPN--FLQ -LSKESAGSTSSKN-SSSDTDDFVLVPH-LS-TD-SYDQ--------PMG-TGRRTSTEF LMYGGQ-----------------------------PHP---------------TQGQPAP VSPR------------------AETTPIPVPTQIRNYQRIKQNLSS-------------S PTTMVFSSP--R-----SGTVRR-SNTSPMGLAKMGSGSPSS--ADVPQI-VSRRLSTG- SSRPYSPSPL-------------------------------------------------- -----------------VGTIPEQLGHCCC-HLQNHEPR--------------------- ----------------------------------------------------SRSS---- SG---G------------------------------------------------------ ---------------------------SPVPSSH-----L--L-GPRLQSAPTLTEFYQ- -TRQKLHKQLS--------DPVQPSSS---C--SHSPQLGRP-ASLGSSPTKLLGSSPRT SDWLQKSP--LPTIIGSPTKTISAPFK---------IPKTQASCNLMALVDSPVPI---- ---KTLS----DARDICAHHCSPYLTGRPAAP-EA--SRT-FG--RSVSTGRLSEPP-IR ISLGG--QAY-QGSTDSLNTER-PMDT-------APAGPCGLIH-----GGS-GSPRTVL FTVGSPPSSSTPPTCSHLGTRPRTTSVGS----NSSAGSLCSTSG---RVYVGSPP-GMA LGTSPPGGFGGGQVMPG--SEGAPSSLRYVPYGTSPPSLEGFITFEAPELPEETLME--R EHTDTLMHLRMM--LSFTDCVLEMAAVRAGET--QVGVSAAPLYPPQDSVVVDQISQLSK EWGQVEQLVLYMKAAQLLASSLHMAKAQIKSTKLNPS--SA------------------- -VKQ-VVKSLNERYKSCISFCRRLTDRLNH-------FFSDKQRFV---DEINSVTAEKL IYNHAVEIVQSAALDEMFKQTEDIA-YRYSKAAMLLDGLSKILQ---------------- ------------------------------------------------------------ ------------------------------------------------D--PTDIENVV- -KYKASVDRRISALCYCTVTL--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >M_musculus_ENSMUSP00000108029 --------------------------------------MEPGRGGV-ET----------- ---VGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQ--TLLGKEIK ILKE---LKHENIVALYDFQEMANSVYLVME--YCNGGDLADYLHTMRTLSEDT------ ------------------VRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRR-AN -----------PSNIRVK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIM SQHYD-GKADLWSIGTIVYQCLTGKAPF-QAS-SPQDLRLFYEKNKTLVPAIPR--ETSA PLRQLLLALLQRNHKDRMDF--DEFFHHPFLDASTPIKKS-----PPVPVPSYPSSGSGS SSSSSSASHLASPP---SL---------GEM-PQ---LQKTLTSPA-----DAAG--FLQ -GSRDS--GGSSKD--SCDTDDFVMVPAQFP-GDLVAE------------AASAKPPPDS LLCSGS----SLVASAGLESHGRTPSPSPTC--------------------------SSS PSPSGRPGPFSSNRY-------GASVPIPVPTQVHNYQRIEQNLQS-------------- --PTQQQTA--R-----SSAIRRSGSTSPLGFGRASPSPPSH--TD-GAM-LARKLSLG- GGRPYTPSPQATL----------------------------------------------- --------------FLPVGTIPERPSWSRVPSPQGADVRV-------------------- ----------------------------------------------------GRSP---- RP---G------------------------------------------------------ ---------------------------SSVPE-HSPRTTG--L-GCRLHSAPNLSDFHV- -VRPKLPKPPT--------DPLGATFS--------PPQTSAPQPCPGLQSCRPLRGSPKL PDFLQRSP--LPPILGSPTK-AGPSFD---------FPKTPSSQNLLTLLARQGVVMTPP R-NRTLP----DLSE-ASPFHGQQLGSGLRPA-ED--TRGPFG--RSFSTSRITDLL-LK AAFGT--QASDSGSTDSL-QEK-PMEI-------APSAGFGGTLHPGARGGGASSPAPVV FTVGSPPSGATPPQST----RTRMFSVGS----SSSLGSTGSSSA---R--------HLV PGACG----------EA--PELSAPGHCCSLADPLAANLEGAVTFEAPDLPEETLME--Q EHTETLHSLRFT--LAFAQQVLEIAALKGSAS--EAAG--GPEYQLQESVVADQISQLSR EWGFAEQLVLYLKVAELLSSGLQTAIDQIRAGKLCLS--ST------------------- -VKQ-VVRRLNELYKASVVSCQGLSLRLQR-------FFLDKQRLL---DGIHGVTAERL ILSHAVQMVQSAALDEMFQHREGCV-PRYHKALLLLEGLQHTLT---------------- ------------------------------------------------------------ ------------------------------------------------D--QADIENIA- -KCKLCIERRLSALLSGVYA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >H_sapiens_ENSP00000324560 --------------------------------------MEPGRGGT-ET----------- ---VGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQ--TLLGKEIK ILKE---LKHENIVALYDFQEMANSVYLVME--YCNGGDLADYLHAMRTLSEDT------ ------------------IRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRR-AN -----------PNSIRVK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIM SQHYD-GKADLWSIGTIVYQCLTGKAPF-QAS-SPQDLRLFYEKNKTLVPTIPR--ETSA PLRQLLLALLQRNHKDRMDF--DEFFHHPFLDASPSVRKS-----PPVPVPSYPSSGSGS SSSSSSTSHLASPP---SL---------GEM-QQ---LQKTLASPA-----DTAG--FLH -SSRDS--GG-SKD-SSCDTDDFVMVPAQFP-GDLVAE------------APSAKPPPDS LMCSGS----SLVASAGLESHGRTPSPSPPC--------------------------SSS PSPSGRAGPFSSSRC-------GASVPIPVPTQVQNYQRIERNLQS-------------- --PTQFQTP--R-----SSAIRRSGSTSPLGFARASPSPPAH--AEHGGV-LARKMSLG- GGRPYTPSPQ-------------------------------------------------- -----------------VGTIPERPGWSGTPSPQGAEMRG-------------------- ----------------------------------------------------GRSP---- RP---G------------------------------------------------------ ---------------------------SSAPE-HSPRTSG--L-GCRLHSAPNLSDLHV- -VRPKLPKPPT--------DPLGAVFS--------PPQASPPQPSHGLQSCRNLRGSPKL PDFLQRNP--LPPILGSPTK-AVPSFD---------FPKTPSSQNLLALLARQGVVMTPP R-NRTLP----DLSE-VGPFHGQPLGPGLRPG-ED--PKGPFG--RSFSTSRLTDLL-LK AAFGT--QAPDPGSTESL-QEK-PMEI-------APSAGFGGSLHPGARAGGTSSPSPVV FTVGSPPSGSTPPQGP----RTRMFSAGP----TGS----ASSSA---R--------HLV PGPCS----------EAPAPELPAPGHGCSFADPITANLEGAVTFEAPDLPEETLME--Q EHTEILRGLRFT--LLFVQHVLEIAALKGSAS--EAAG--GPEYQLQESVVADQISLLSR EWGFAEQLVLYLKVAELLSSGLQSAIDQIRAGKLCLS--ST------------------- -VKQ-VVRRLNELYKASVVSCQGLSLRLQR-------FFLDKQRLL---DRIHSITAERL IFSHAVQMVQSAALDEMFQHREGCV-PRYHKALLLLEGLQHMLS---------------- ------------------------------------------------------------ ------------------------------------------------D--QADIENVT- -KCKLCIERRLSALLTGICA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >R_norvegicus_ENSRNOP00000053633 --------------------------------------MEPGRGGV-ET----------- ---VGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQ--TLLGKEIK ILKE---LKHENIVALYDFQEMANSVYLVME--YCNGGDLADYLHTMRTLSEDT------ ------------------VRLFLQQIAGAMQLLHSKGIIHRDLKPQNILLSNPGGRR-AN -----------PSNIRVK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIM SQHYD-GKADLWSIGTIVYQCLTGKAPF-QAS-SPQDLRLFYEKNKTLVPAIPR--ETSA PLRQLLLALLQRNHKDRMDF--DEFFHHPFLDASTPIKKS-----PPVPVPSYPSSGSGS SSSSSSASHLASPP---SL---------GEM-PQ---LQKTLTSPA-----DAAG--FLQ -GSRDS--GGSSKD--SCDTDDFVMVPAQFP-GDLVPE------------AASAKPPPDS LLCSGS----SLVASAGLESHGRTPSPSPTC--------------------------SSS PSPSGRPGPFSSNRY-------GASVPIPVPTQVHNYQRIEQNLQS-------------- --PTQQQTA--R-----SSAIRRSGSTSPLGFGRASPSPPSH--TD-GAM-LARKLSLG- GGRPYTPSPQATL----------------------------------------------- --------------FLPVGTIPERPSWSRVPSPQGADVRA-------------------- ----------------------------------------------------GRSP---- RP---G------------------------------------------------------ ---------------------------SSVPE-HSPRTTG--L-GCRLHSAPNLSDFHV- -VRPKLPKPPT--------DPLGATFS--------PPQTSAPQPCPGLQSCRPLRGSPKL PDFLQRSP--LPPILGSPTK-AGPSFD---------FPKAPSSQSLLTLLARQGVVMTPP R-NRTLP----DLSE-AGPFQGQQLGSGLRPA-ED--TRGPFG--RSFSTSRLTDLL-LK AAFGT--QASDSGSTDSL-QEK-PMEI-------APSAGFGGTLHPGARAGGASSPAPVV FTVGSPPSGTTPPQST----RTRMFSVGS----SSSLGSTGSSSA---R--------HLV PGACA----------EA--PELSAPGYCCSLADPLAANLEGAVTFEAPDLPEETLME--Q EHTETLHSLRFT--LAFAQQVLEIAALKGSAS--EAAG--GPEYQLQESVVADQISQLSR EWGFAEQLVLYLKVAELLSSGLQTAIDQIRAGKLCLS--ST------------------- -VKQ-VVRRLNELYKASVVSCQGLSLRLQR-------FFLDKQRLL---DGIHGVTAERL ILSHAVQMVQSAALDEMFQHRESCV-PRYHKALLLLEGLQHTLT---------------- ------------------------------------------------------------ ------------------------------------------------D--QADIENIA- -KCKLCIERRLSALLSGVYA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >O_anatinus_ENSOANP00000020106 ASPFPSAASLPPLHLPSAKLPFPPFLLLLPLSLPLPSALCSSAHLM-EV----------- ---VGDFEYSKKDLIGHGAFAVVFKGRHRKKTDWEVAIKSINKKNLSKSQ--ILLGKEIK ILKE---LQHENIVALYDVQELPNSVFLVME--YCNGGDLADYLQGTFCLFSKE------ -----------------------HQIAAAMRILHGKGIIHRDLKPQNILLSYASRRK-ST -----------ISGIRVK----I-----ADFGFARYLHSNM-MAATLCGSPMYMAPEVIM SQHYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNRSLIPSIPR--ETSP YLTDLLLNLLQRNQKDRMDF--EAFFCHPFFEQVP-VKKS-----CPVPVPIYAGSVSGS SCG-SPSCRFASPP---SL---------PDM-QHI--QEDNLSSPP----LGPPN--FLQ -VSKDSA-STSSKN-SSCDTDDFVLVPHNIS-SDHSYDM--------PMGTAGRRASSEF LVCGGQ----C----------------------------------------------QPS LSPR------------------SETAPIPVPTQLRNYQRIEQNLTS-----------TGS PGSNPHGSP--R-----SAVVRR-SNTSPMGFLKMGSCSPVP--ADTVQT-IGRRLSTG- SSRPYSPSPL-------------------------------------------------- -----------------VGTIPEQLGHCCCGQPQGHESR--------------------- ----------------------------------------------------SRNS---- S----G------------------------------------------------------ ---------------------------SPVPPSQSPQSLL--L-GARL-----LTDIYQ- -NKQKLRKQHS--------DPVCPSYAGYGY--SHTPQPSRP-VSLGTSPTKHTGSSPRS SDWLFKTP--LPTIIGSPTK-ATAPFK---------IPKTQGTSNLLALVTRQGPTDAPL P-SKGGA----DPRE-FSNFLTVQGSERPAAE-QQ--SKTTFG--RSVSTGRLSDQQ-MK TPLGG--QLY-QGSTESLNAER-PMDI-------APAGPCGVILAQPA-ATG-ASSRAVM FTVGSPPSSATPPTCTHMVLRTRTTSVGS----NSSGGSLCSTSG---RVFMGSPP-GLY MGSSP----------PG--AEAAP-SLKYTPYGNSPPSLEGFITFEAPELPEETLME--R EHTDTLRHLNMM--LTFTECVLDLTAIRGGNP--ELCTSAVSLYQIQESVVVDQISQLSK DWGQVEQLVLYMKAAQLLASSLHLAKAQIKSGKLNPS--TA------------------- -VKQ-VVKNLNERYKFCIAMCKKLTEKLNH-------FFSDKQRFI---DEINSVTAEKL IYNCAVEMVQSAALDEMFQQTEDIV-YRYHKAALLLEGLAKILQ---------------- ------------------------------------------------------------ ------------------------------------------------D--PGDIENVH- -KYKSSIERRLSALCYSTVTV--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >T_rubripes_ENSTRUP00000029855 ---------------------------------------------M-ES----------- ---VGKFEFSRKDLIGHGAFAVVFKGRHKEKRDWQVAVKCISKKNLAKSQ--ALLGKEIK ILKE---LKHENIVRLLDYQEIGGCVYLVME--YCNGGDLAEYLHTKGTLSEDT------ ------------------IRIFLQQIAQAMEVLRIKGILHRDLKPQNILLCHPVGRR-SS -----------PINTCIK----I-----ADFGFARHLQTNT-MAATMCGSPMYMAPEVIM SQHYD-AKADLWSIGTIVYQCLTGKAPF-RAS-TPQELRLFYESNRTLLPSVPK--ETSH DLKDLLLGLLQRNHQERISFVTEEFFHHPFLETSSTTKKS--------PTLSYPSSASAS SSCSSSTSHLASPQ---SN---------LAQ-QQE--TAVSLTSHS----DGELN--QIQ LKEEADMVCDNGRD-TPSDLEEYVMVPAQFP-SEYTCE------------GVAASPIESC VIYSGK------------------------------------------------------ ------PARPVGFTS-------CQTVPVPVPTQIQNYQRLKQNLQP-------------- -----VGCT--RYMKLLHRIGVRSWLIIPL--------------PQSISVFTGARSATK- CARPQQLSPA-------------------------------------------------- -----------------VATTPKTPEQALPLGTRTGLL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GPSPDTQDASSIKVSLSAFRGERSVNITPSYFQ TFSPQNNTSALNLLYF---QQVYPDRSSSAVDLQSL---AANQSNLGTISANKKGPFKRS EQQELGIPVRLTVKVGERVP-VCGVYC---------VPFADLLTAVLKILVQPIETKK-- -----------NIRNWYLIIKYSFFPSSTESP-NEFSAPIIAG--LSLSTSRLSDMV-LK GAFGA--QLLENRSDGSFNCEK-SLDV-------HLAHSSKWVLHPEEPVLRDSFSQKIL FLNGMRTYLTMFSGC-----NHYLPSLLT----LLIVFSHHFTFS---LLIRVIGEGYIP QNSFS---------------NYIPLSQRLGDSESMAATPNSGLFFHPPELPVDTLME--Q AHTDTLTDLHFT--LAFAHCVMELASSKEPKL---GAASPADVSSPEQSLVTDQISQLSK EWSYAEQLVLYMKAEEFLSAALHTAKENINKGQLLPS--NI------------------- -VKQ-VIRKLNESYKTCVTQCHSLNRRLQT-------FLLDKQKLI---DRFSGLTAEKL LYNHTVHMVQSAALDEMFHCGSASL-QRYHKALLLMEGLYRIVT---------------- ------------------------------------------------------------ ------------------------------------------------E--QKDIDSID- -KCKQCIERRLSAL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >O_latipes_ENSORLP00000017355 ---------------------------------------------M-ES----------- ---VGKFEFSRKDLIGHGAFAVVFKGRHKEKHSWEVAVKCINKKNLAKSQ--SLLGKEIK ILKE---LKHGNIVRLLDYQEIGGCVYLVME--YCNGGDLAEYLHSKGTLSEDT------ ------------------IRIFLQQIAQAMKVLQSKGILHRDLKPQNILLCHPEGRK-SS -----------SINASIK----I-----ADFGFARHLQTNM-MAATLCGSPMYMAPEVIM SQNYD-AKADLWSIGTIMYQCLTGKAPF-HAS-SPQELRLFYESNTTLLPSIPK--ETSP NLRHLLLGLLQRNHKERITF--DEFFHHPFLETSTSTKKC-----LLVAPISYLTSASGS SSSSSSTSQLASPQ---KC---------SDG-ETH--QPKEMHSPA----EDTAG--SLL -KEKA---NPDIRN-TLSYAEDYVMVPAQYL-SEYTYE--------------MESTNESC LMC------------------------------------------------------RFI CKPRSSPVKLDGPAR-------SKSVPIPVPTQIQNYQRMNQNLQH-------------- --AGMHGST--RHVH------ITVLSLQAMACCTLGSRGSR--------VDCGMRRASA- PAIASFATANFSNVIPGDLYTMKMCCCFISSLLRSHFIFL-----------KTYIPEQFF LTLTLSF------YICVVGQIPKTLEQNFPLSSRTELL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SVFPDVQVTTNPKF-LVHIDCLDLTLGIA---- -SSRSLSSDTVTISFQHLDQPKKLNWTETVPDLQGLYKFPAFQTNIDHKSMHKKGPFKRS EQVIKTIW----------------------------CLKAFLAVKHLA------------ -----------KLVPWSPHFLMSVCHTKMHFE-MSDRTKALAF--RSLSTGRLSDML-LK AAFGA--NLFEEESDESFGTDK-SMDP-------TGMRSGSGKHFAFTVSLSEDSPPPVV FTMGSPSQGTTPPDAK----VSRMFSGGC----LRFGNSGSPSHINSAWLLNSRTP---- ----------------------PRGARRNSETDAMDTILHRNSLFHLPGLPEDTLME--E AHLDALSDLRFT--LAFVHCIMELASSKDPEL--EACSS--DISFLQKSLVTDQISLLSK EWSFAEQLVLYMKAEEFLSSALHTAKENIKQGQLQPS--SI------------------- -VKQ-VIRKLNDLYKSCVSFCRSLNDRLQT-------FLLDKQKLM---DRFGGLTAEKL IYSHTVHMVQSTALDEMFHYGTSSV-QRYNKALLLMEGLSRILT---------------- ------------------------------------------------------------ ------------------------------------------------E--QRDIDSID- -KCKECIEKRISAL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >B_taurus_ENSBTAP00000017268 --------------------------RLSPGLPGPVRAMEPGRGGL-EA----------- ---VGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQ--TLLGKEIK ILKE---LKHENIVALYDFQEMANSVYLVME--YCNGGDLADYLHTMRTLSEDT------ ------------------IRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRR-AN -----------PNNIRVK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIM SQHYD-GKADLWSIGTIVYQCLTGKAPF-QAS-SPQDLRLFYEKNKTLVPTIPR--ETSA PLRQLLLALLQRNHKDRMDF--DEFFHHPFLDASATVKKS-----PPVPVPSYPSSGSGS SSSSSSTSHLASPP---SL---------GEMQQE---LQKTLTSPA-----EAAG--FLH -GSRDS--GGSSKD-SSCDTDDFVMVPAQFP-GDLVAE------------AAGAKPPPDS LMCSGS----SLAASTGLDSRGRTPSPSPPC--------------------------GSS LSPSGRTGTFSSSRC-------GASVPIPVPTQVQNYQRIEQNLQS-------------- --PTQYQTA--R-----SSAIRRSGSTSPLGFARASPSPPSH--AEHGAA-LARKLSLG- GGRPYTPSPQ-------------------------------------------------- -----------------VGTIPERPGWSGAPSPQASEMRG-------------------- ----------------------------------------------------GRSP---- RP---G------------------------------------------------------ ---------------------------SSAPE-HSPHTSG--L-GYRLHSAPNLSDLHV- -VRPKLPKPPT--------DPLGVAFG--------HPQASPPQPSHGLQSCRPLRGSPKL PDFLQRNP--LPPILGSPTK-TVPVFE---------FTKTPSSQNLLTLLARQGVVMTPP R-NRTLP----DLSE-AGPFQGQQLGPGLRPT-ED--TKGAFG--RSLSTGRLTDLL-LK AAFGT--QAPDSGSTDSL-QEK-PMEI-------APSAGFGGNLHPGARAGGASSPSPVV FTVGSPPSGTTPPQGP----RTTMFSVGS----SSSLSSAGSSSA---R--------HLA PGAYS----------EA-TLEVPAPGHCCSFADPVTANLEGAVTFEAPDLPEETLME--Q EHTEILHSLRFT--LVFVQHILEIAALKGSAS--EAAG--GPEDQLQESVVADQISLLSR EWGFAEQLVLYLKVAELLSSGLQTAIDQIRAGKLCLS--ST------------------- -VKQ-VVRKLNELYKTSVVSCQSLSLRLQR-------FFLDKQRLL---DRIQSVTAEKL IFSHAVQTVQSAALDEMFHRREDCV-QRYHKALLLMEGLQQILT---------------- ------------------------------------------------------------ ------------------------------------------------D--QADVENIA- -KCKLCIERRLSALLTGICA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >G_aculeatus_ENSGACP00000023344 ---------------------RVIRPARSPARPSSSNSAIRLRRAM-ET----------- ---VGKFEFSRKDLIGHGAFAVVFKGRHREKHDWEVAVKCINKKNLAKSQ--TLLGKEIK ILKE---LKHENIVALLDFQETASSVYLVMETQYCNGGDLADYLHTKGTLSEDT------ ------------------IRVFLQQIAGAMRVLQGKGIIHRDLKPQNILLSYPPGRR-SH -----------SNNTCIK----IDFVPTADFGFARYLQSNM-MAATLCGSPMYMAPEVIM SQSYD-AKADLWSIGTIVFQCLIGKAPF-QAS-SPQDLRLFYEKNKTLSPNIPR--ETSS HLRHLLLGLLQRNHKDRMDF--DEFFCHPFLEASSSLKKS----TPAVSMTCIPSSASAS SCSSSSTSHLASPP---SL---------AEG-QHL--RAKALASPT----QEAAG--FLL -KDSSGG-AGSSKNSSSCDTDDFVMVPAHFTTGELTCE---------------SKVLQDS LMNSGS----SLLASAGLCGQVKTPPQSPPC--------------------------SGS PSPVSRPSEFSGSSCGGSYGNHCRSSPIPVPSQVQNYQRMEQNMHC-------------- --TRLDGSP--R----PSAPVRRCSSGSSLGFARAGPSPPCG----QGAAHANRRLSLG- GARPFQPSPQ-------------------------------------------------- ------------------GTAEASPLWTSSTTAAGEQKHS---------------DLCPP ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PTAPQPHPQQAPG--L-GARLHSAPSLLECTGA AGKQKIRKQHS--------DPAVA-------------------PSAGLKTLRPLHSSPRL SELMQRSP--LPTILGSPSR-AIPPFE---------FPKPPSSPNLVTFLTQQGLVIGSP C-SRTAPPEPRDVGQ-RALTQVIQPAHCIHRR-SD--DAKVFG--RSQSAGRLSDML-LM AAFGPGGPVGDRDSAENLTSEK-TIDI---------MVPPGGGGSP---APGSISPAQVV FTVGSPPSASSPPHTS----RQRKYSVNP------TMSSSGSFTS---R--------YPQ TCTYL----------DG--FEAPS-SPRYGFTDPITANMGGRVTFEPPELPEETLME--Q EHTDIVQSLRFT--LDFARCLMEVAGACGVAALREQEDVSHPCLLQQQSVVADQISSLSR EWSHAEQLVLYLKTAELLSTALHTAMERVKQGKLYPS--ST------------------- -VKQ-IVRRLNELYKSSVASCRSLSTRLER-------FFSRKHRLM---DQITSITAERL LFSHTVQMVQTAALDEMFHQGEASV-LRYHKALLLMEGLSLLLT---------------- ------------------------------------------------------------ ------------------------------------------------E--QDDILSVS- -KCKECIERRLTALQSGLCV---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >E_caballus_ENSECAP00000007293 ------------------------------------------------------------ -----------------------------QKTDWEVAIKSINKKNLSKSQ--LLLGKEIK ILKE---LQHENIVALYDVQELPNSVFLVME--YCNGGDLADYLQAKGTLSEDT------ ------------------IRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRK-SS -----------VSGIRIK----I-----ADFGFARYLHSNM-MAATLCGSPMYMAPEVIM SQHYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNRSLMPSIPR--ETSP YLANLLLGLLQRNQKDRMDF--EAFFSHPFLEQVP-VKKS-----CPVPVPVYAGSVSGG SCGSSPSCRFASPP---SL---------PDM-QHI--QEENLSSPP----LGPPN--YLQ -VSKDSA-STSSKN-SSCDTDDFVLVPHNIS-SDHSYDM--------PVGTVGRRASNEF LVCGGQ----C----------------------------------------------QPT VSPH------------------SEAAPIPVPTQIRNYQRIEQNLTS-----------AAS SGTNLHGSP--R-----STVVRR-SNTSPMGFLRLGSCSPAP--ADTVQT-VGRRLSTG- SSRPYSPSPL-------------------------------------------------- -----------------VGTIPEQLSQCCCGHPQGHESR--------------------- ----------------------------------------------------SRNS---- S----G------------------------------------------------------ ---------------------------SPVPQAQSPQPLL--L-GARLQSAPTLTDIYQ- -NKQKLRKQHS--------DPVCPSHAGAGY--SYSPQPSRP-GSLGTSPTKHMGSSPRS SDWFFKTP--LPTIIGSPTK-TTAPFK---------IPKTQASSNLLALVTRHGPSEE-- Q-SKDEN----DPRE-CSHCLLVQGSERQKPE-QQ--NKAVFG--RSVSTGKLSDQQ-VK TPLGG----H-QGSTDSLNTER-PMDI-------APAGACGVVLSPPV-GTA-ASSRAVL FTVGSPPHSATAPTCTHMVLRTRTTSVGS----SSSGGSLCSASG---RVCVGSPP-GPC PGSSP----------PG--AEIAP-SLRYMPYGASPPSLEGLITFEAPELPEETLME--R EHTDTLRHLNVM--LMFTECVLDLTAVRGGNP--ELCTSAVSLYQIQESVVVDQISQLSK DWGRVEQLVLYMKAAQLLASSLHLAKAQIKSGKLSPS--TA------------------- -VKQ-VVKNLNERYKFCITMCKKLTEKLNR-------FFSDKQRFI---DEINSVTAEKL IYNCAVEMVQSAALDEMFQQTEDIV-YRYHKAALLLEGLTKILQ---------------- ------------------------------------------------------------ ------------------------------------------------D--PADIENVH- -KYKSSIERRLSALCYSASAM--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >M_domestica_ENSMODP00000031918 ---------------------------------------------M-ET----------- ---VGKFEFSRKDLIGHGAFAVVFKGRHKEKHDLEVAVKCINKKNLAKSQ--TLLGKEIK ILKE---LKHENIVALYDFQEVASSVYLVME--YCNGGDLADYLHSMRTLSEDT------ ------------------IRLFLQQIAGAMKMLHSKGIIHRDLKPQNILLSYSGGRK-SN -----------PNNIRVK----I-----ADFGFARYLQNNM-MAATLCGSPMYMAPEVIM SQHYD-AKADLWSIGTIIYQCLTGKAPF-QAS-SPQDLRLFYEKNKTLLPSIPR--ETSS PLRQLLLGLLQRNHKDRMDF--DEFFHHPFLDASSSIKKS-----PPVPMPSYPS--SGS SSSSSSASHLASPP---SL---------GEMQQQ---LQKTLTSPA----PDPGG--FLQ -GSKDS--GGSSKN-SSCDTDDFVMVPAQFP-SKTRWE------------RLGRVGNRSI LMCTSG----SVCA---------------------------------------------- -----------FSRY-------GPSVPIPVPTQIQNYRRIEQNLQS-------------- --PNQYTPPPPR-----SGMVRRSSSTSPLGF-KTGISPPSF--PEHGAT-FPRKSSLG- GAKPYNPSPQGES----------------------------------------------- -----------------QSLLPRPAGRACVQHTAGSPRRKAPRCVELAAVAGSPDLVAIF FLSNSPSYNHRKPFSPPRNSYTLKYYWSLQLIFTGDLGSSRSSLVFSNPGLASRDEWASS LL---G------------------------------------------------------ ---------------------------TSLPE-HSPR--G--L-GYRLHSAPNLSDLHV- -VRPKLPKPPT--------EPLVAPFG--------YPQASPPQQHYGLQPCRTLRASPKL PDFMQRNP--LPPILGSPTK-AVPAFE---------FPKTPSSQNLLTLLAHQGVVVTPT R-NRTLP----DLRE-MGHFHSPP-SLGLRPV-EE--LKGPFG--RSLSTGRLTDLL-LK AAFGS--QAPDTGSNESL-QEK-PMEI-------APSAGYGGNLLPGARTGGSSSPSPVI FTVGSPPSGTTPPQVP----RTRMFSVGS----SSSQSSGGSFSG---R--------HLI PGMGG----------EA--SEAPGNLRCYGFTDPITANLEGAVTFEAPDLPEETLME--Q EHTDILRSLRFT--LAFVHCVMEMAAAKGSSG--EMSSSVASEYHLQESIVADQISLLSR EWRDGEQLGVSMTPAPLGGWSPWAGRKAGPRADLTRSLLAY------------------- -LAV-VVRKLNELYKSSVSSCHCLNLQLQK-------FFLDKQKLM---DRINSITAEKL IFNYAVQMVRSAALDEMFHHREDCV-QRYHKALLLMEGLQQILT---------------- ------------------------------------------------------------ ------------------------------------------------E--QADIENIN- -KCKMCIERRLSAL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >M_mulatta_ENSMMUP00000027852 ------------------------------------------------------------ -----------------------------QKTDWEVAIKSINKKNLSKSQ--ILLGKEIK ILKE---LQHENIVALYDVQELPNSVFLVME--YCNGGDLADYLQAKGTLSEDT------ ------------------IRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRK-SS -----------VSGIRIK----I-----ADFGFARYLHSNM-MAATLCGSPMYMAPEVIM SQHYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNRSLMPSIPR--ETSP YLANLLLGLLQRNQKDRMDF--EAFFSHPFLEQVP-VKKS-----CPVPVPVYSGSVSGS SCGSSPSCRFASPP---SL---------PDM-QHI--QEENLSSPP----LGPPN--YLQ -VSKDSA-STSSKN-SSCDTDDFVLVPHNIS-SDHSYDM--------PLGTAGRRASNEF LVCGGQ----C----------------------------------------------QPT VSPH------------------SETAPIPVPTQIRNYQRIEQNLTS-----------TAS SGTNVHGSP--R-----SAVVRR-SNTSPMGFLRLGSCSPVP--ADTAQT-VGRRLSTG- SSRPYSPSPL-------------------------------------------------- -----------------VGTIPEQFSQCCCGHPQGHDSR--------------------- ----------------------------------------------------SRNS---- S----G------------------------------------------------------ ---------------------------SPVPQAQSPQSLL--L-GARLQSAPTLTDIYQ- -NKQKLRKQHS--------DPVCPTHAGAGY--SYSPQPSRP-GSLGTSPTKHLGSSPRS SDWFFKTP--LPTIIGSPTK-TTAPFK---------IPKTQASSNLLALVTRHGPAEE-- Q-SKDGN----EPRE-CAHCLLVQGSERQRAE-QQ--SKAVFG--RSVSTGKLSDQQ-GK TPIGG----H-QGSTDSLNTER-PMDI-------APAGACGIVLAPPA-GIA-ASSRAVL FTVGSPPHSAVAPTCTHMLLRARTTSVGP----SNSGGSLCAVSG---RVCVGSPP-GPG FGSSP----------PG--AEAAP-SLRYVPYGASPPSLEGLITFEAPELPEETLME--R EHTDTLRHLNVM--LMFTECVLDLTAVRGGNP--ELCTSAVSLYQIQESVVVDQISQLSK DWGRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPS--TA------------------- -VKQ-VVKNLNERYKFCITMCKKLTEKLNR-------FFSDKQRFI---DEINSVTAEKL IYNCAVEMVQSAALDEMFQQTEDIV-YRYHKAALLLEGLTKILQ---------------- ------------------------------------------------------------ ------------------------------------------------D--PADIENVH- -KYKCSIERRLSALCHSTATV--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >A_carolinensis_ENSACAP00000000717 ---------------------------------------------M-EA----------- ---VGDFEYSKKDLIGHGAFAVVFKGRHRKKTDWEVAIKSINKKNLSKSQ--LLLGKEIK ILKE---LQHENIVALYDVQELPNSVFLVME--YCNGGDLADYLQAKGTLSEDT------ ------------------IRVFLQQIAAAMRILHGKGIIHRDLKPQNILLSYANRRK-SS -----------LSGIRIK----IG---KSDFGFARYLQSNM-MAATLCGSPMYMAPEVIM SQHYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNRNLIPSVPR--ETSP YLADLLLALLQRNQKDRMDF--EAFFNHPFLDQVSTVKKS-----CPVPVPAYTGSVSGS SCGSSPSCRFASPP---VS---------SIL-TFP--SLAARRSHP----CSSQG--YRR -VVGLSY-NSGEER-LE---EDCIAVLGTPS-GSNPYDM--------PLAATGRRGSREF LMCGGG-EAPC---------------------------------------------QPPA VSPR------------------SETAPIPVPTQLRNYQRIEQNLTSA---------AAAS PSSNPHGSP--R-----SGVVRR-SNTSPMGFLKTGSCSPVP--AD------GRRLSTGS SSRPYSPSPL-------------------------------------------------- -----------------VGTIPEQLGHCCCGQIQGHESR--------------------- ----------------------------------------------------SRNS---- S----G------------------------------------------------------ ---------------------------SPAPASHSPQSLV--MAGARLQNTPTLTDIYQ- -NKQKLRKQHS--------DPVCPSYAAHGHPPPQPTQPPRP-VSLGTSPTKHPGSSPRG SDWLFKTP--LPTIIGSPTK-ATAPFK---------IPKTQASSNLVGLLARPGSAEAQL PPAKEAG----EMAREFPHFHSAQGAERQAQQ-QQHHGKALFG--RSVSTGKLSDQQ-AK AALGG--QLY-QGSTDSLNTER-PMDT-------APPAACVLAAPPPCLGTG-AGSRAVM FTVGSPPNSATPPTCAHMLLRARTTSVGS----NSSGGSLCSTSG---RVLVGSPP-GIY SGSSP----------PG--AEAAP-CLKYMSYGTSPPSLEGFITFEAPELPEETLME--V RNKTQKHYLSTL--EEWMVKVFKIFQSRGATA--EKALSLVPTNRDCEVSFLSLPPSLCK AWTQVEQLVLYMKAAQLLASSLHLAKAQIKSAKLNLS--TA------------------- -VKQ-VVKNLNERYKFCICMCKRLTEKLNR-------FFSDKQRFV---DEVNSVTAEKL IYSCAVEMVQSAALDEMFQQTEDIA-YRYHKAALLLEGLAKILQ---------------- ------------------------------------------------------------ ------------------------------------------------D--PADIENIN- -KYKASIERRLSALCYGAVAV--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >P_pygmaeus_ENSPPYP00000009920 ---------------------------------------------M-EV----------- ---VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQ--ILLGKEIK ILKE---LQHENIVALYDVQ--------------------------KGTLSEDT------ ------------------IRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRK-SS -----------VSGIRIK----I-----ADFGFARYLHSNM-MAATLCGSPMYMAPEVIM SQHYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNRSLMPSIPR--ETSP YLANLLLGLLQRNQKDRMDF--EAFFSHPFLEQVP-VKKS-----CPVPVPMYSGSVSGS SCGSSPSCRFASPP---SL---------PDM-QHI--QEENLSSPP----LGPPN--YLQ -VSKDSA-STSSKN-SSCDTDDFVLVPHNIS-SDHSNDM--------PMGTAGRRASNEF LVCGGQ----C----------------------------------------------QPT VSPH------------------SETAPIPVPTQIRNYQRIEQNLTS-----------TAS SGTNVHGSP--R-----SAVVRR-SNTSPMGFLRLGSCSPVP--ADTAQT-VGRRLSTG- SSRPYSPSPL-------------------------------------------------- -----------------VGTIPEQFSQCCCGHPQGHDSR--------------------- ----------------------------------------------------SRNS---- S----G------------------------------------------------------ ---------------------------SPVPQAQSPQSLL--S-GARLQSAPTLTDIYQ- -NKQKLRKQHS--------DPVCPSHTGAGY--SYSPQPSRP-GSLGTSPTKHLGSSPRS SDWFFKTP--LPTIIGSPTK-TTAPFK---------IPKTQASSNLLALVTRHGPAEE-- Q-SKDGN----EPRE-CVHCLLVQGSERQRAE-QQ--SKAVFG--RS-STGK-SDHQ-GK TPICR----H-QGSTDSLNTER-PMDI-------APAGACGGVLAPPA-GTA-ASSRAVL FTVGSPPHSAAAPTCTHMFLRTRTTSVGP----SNSGGSLCAMSG---RVCVGSPP-GPG FGSSP----------PG--AEAAP-SLRKVPYGASPPSLEGLITFEAPELP-DTLME--R EHTDTLRYLNVM--LMFTECVLD-TAMRGGNL--ELCTSAVSLYQIQESVVVDQISQLSK DWGRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPS--TA------------------- -VKQ-VVKNLNERYKFCITMCKKLTEKLNR-------FFSDKQRFI---DEINSVTAEKL IYNCAVEMVQSAALDEMFQQTEDIV-YRYHKAALLLEGLSKILQ---------------- ------------------------------------------------------------ ------------------------------------------------D--PADIENVH- -KYKCSIERRLSALCHSTATM--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >C_familiaris_ENSCAFP00000026786 ---------------------------------------------M-EV----------- ---VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQ--ILLGKEIK ILKE---LQHENIVALYDVQELPNSVFLVME--YCNGGDLADYLQAKGTLSEDT------ ------------------IRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRK-SN -----------VSGIRIKIVCEI-----ADFGFARYLHSNM-MAATLCGSPMYMAPEVIM SQHYD-AKADLWSIGTVVYQCLVGKPPF-QSSCCPVTKRFFEPENWSKSPSIPR--ETSP YLANLLLGLLQRNQKDRMDF--EAFFSHPFLEQVP-VKKS-----CPVPVPVYAGSVSGS SCGSSPSCRFASPP---SL---------PDM-QHI--QEENLSSPP----LGPPN--YLQ -VSKDSA-STSSKN-SSCDTDDFVLVPHNIS-SDHSYDM--------PMGTAGRRASNEF LVCGGQ----C----------------------------------------------QPT VSPH------------------SETAPIPVPTQIRNYQRIEQNLTS-----------TAS SGTNLHGSP--R-----STVVRR-SNTSPMGFLRLGSCSPAP--ADTVQT-VGRRLSTG- SSRPYSPSPL-------------------------------------------------- -----------------VGTIPEQFSQCCCGHPQGHESR--------------------- ----------------------------------------------------SRNS---- S----GSLLKGIKLIQNILLSYFLESWSVLAYYIDNENQSRKGNFIPLINTILDYGYRSL PLLVAADKSSQHTHHHYLLSPENTNDSSPVPQAQSPQPLL--L-GARLQSAPTLTDIYQ- -NKQKLRKQHS--------DPVCPSHAGTGY--SYSPQPSRP-GSLGTSPTKHMGSSPRS SDWFFKTP--LPTIIGSPTK-TTAPFK---------IPKTQASSNLLALVTRHGPTEG-- Q-SKDGN----DPRE-CSHCLLVQGSERQKSE-QQ--NKAVFG--RSVSTGKLSDQQ-VK IPLGG----H-QGSTDSLNTER-PMDIV------APAGACGGVLAPPI-GTA-ASSRAVL FTVGSPPHSATAPTCTHMVLRTRTTSAGS----SSSGGSVCSASG---RVCVGSPPLGPC LGSSP----------PG--AEAAP-GLRYMPHGASPPSLEGLITFEAPELPEETLME--R EHTDTLRHLNVM--LTFTECVLDLTAVRGGHP--ELCTSAVSLYQIQESVVVDQISQLSK DWGRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPS--TA------------------- -VKQ-VVKNLNERYKFCITMCKKLTEKLNR-------FFSDKQRFI---DEINSVTAEKL IYNCAVEMVQSAALDEMFQQTEDIV-YRYHKAALLLEGLTKILQ---------------- ------------------------------------------------------------ ------------------------------------------------D--PADIENVH- -KYKTSIERRLSALCCSTATL--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >C_familiaris_ENSCAFP00000009679 ------------------------------------------------------------ -----------------------------QKHDLEVAVKCINKKNLAKSQ--TLLGKEIK ILKE---LKHENIVALYDFQEMANSVYLVME--YCNGGDLADYLHTMRTLSEDT------ ------------------IRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRR-AN -----------PNNIRVK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIM SQHYD-GKADLWSIGTIVYQCLTGKAPF-QAS-SPQDLRLFYERNKTLVPTIPR--ETSA PLRQLLLALLQRNHKDRMDF--DDFFHHPFLDASATVKKS-----PPVPVPSYPSSGSGS SSSSSSTSHLASPP---SL---------GEMHQQ---LQKTLTSPA-----DAAG--FLQ -GSRGS--GGSSKD-SSCDTDDFVMVPAQFP-GDLVAE------------AAGAKPPPDS LMCSGS----SLVASAGLESRGRTPSPSPPCS-------------------------SSS PSPSGRAGPF-SSRC-------GVSVPIPVPTQVHNYQRIEQNLQS-------------- --PTQYQTT--R-----SSAIRRSGSTSPLGFARASPSPPSH--TEHGAA-LTRKLSLG- GGRPYTPSPQAPL----------------------------------------------- --------------SAQVGIIPERPGWSGAPSPQGAEMRG-------------------- ----------------------------------------------------GRSP---- RP---G------------------------------------------------------ ---------------------------SSVPE-PSPHTAG--L-GYRLHSAPNLSDLHV- -VRPKLPKPPT--------DPLGTAFG--------HPQSSPPQPAHGLQSCRPLRGSPKL PDFLQRNP--LPPILGSPTK-ALPAFD---------FPKNPSSQNLLTLLARQGVVMTPP R-NRTLP----DLSE-AGPFQGQQLGPGLRPT-ED---KSPFG--RSLSTGRLTDLL-LK AAFGT--QAPDSGSTDSL-QEK-PMDI-------APSAGLGGNLHPGARAGGASSPSPVV FTVGSPPSGTTPPQGP----RTRMFSVGS----SSSLGSVGSSSA---R--------HLA PGACS----------EA-APEVPAPSHCCSFADPVTANLEGAVTFEAPDLPEETLME--Q EHTEILHSLRFT--LVFVQHVLDIAALRGSAS--NTAG--GPEYQLQESVVADQISLLSR EWGFAEQLVLYLKVAELLSSGLQTAIDQIRAGKLCLS--ST------------------- -VKQ-VVRKLNELYKASVVSCQGLSLRLQR-------FFLDKQRLL---DRIQSVTAEKL IFSHAVQTVQSAALDEMFHRREDCV-QRYHKALLLMEGLQHILT---------------- ------------------------------------------------------------ ------------------------------------------------D--QADVENIA- -KCKLCIERRLSALLTGISA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >E_caballus_ENSECAP00000014390 ------------------------------------------------------------ -----------------------------------VAFKCINKKNL-KSQ--TLLGKE-K ILKE---LKHENIVALYDFQEMANSVYLVME--YCNGGDLADYLHTMRTLSEDT------ ------------------IRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPSGRR-AN -----------PNNIRVK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIM SQHYD-GKADLWSIGTIVYQCLTGKAPF-QAS-SPQDLRLFYEKNKTLVPIIPR--ETSA PLRQLLLALLQRNHKDRMDF--DEFFHHPFLDASATVKKS-----PPVPVPSYPSSGSGS SSSSSSTSHLASPP---SL---------GEMQQQ---LQKTLTSPA-----DAAG--FLQ -GSRDS--GASSKD-SSCDTDDFVMVPAQFP-GDLVAE------------AAGAKPLPDS LMCSGS----SLVASAGLGSHGRTPSPSPPC--------------------------SSS PSPSGRAGPFSSSRC-------GASVPIPVPTQVQNYQRIEQNLQS-------------- --PTQCQAQ--R-----SSAIRRSGSTSPLGFARASPSPPSH--AEHGAA-LARKLSLG- GGRPYTPSPQAGL----------------------------------------------- -------------GQGEVGTIPERPGWSRAPSPQGAEMRG-------------------- ----------------------------------------------------GRSP---- RP---G------------------------------------------------------ ---------------------------SSVPE-HSPHTAG--L-GCRLHSAPNLSDLHV- -VRPKLPKPPT--------DPLGVVFG--------HPQASPPQPSHGLPSCRPLRGSPKL PDFLQRNP--LPPILGSPTK-AMPTFD---------FPKTPSSQNLLTLLARQGVVMTPP R-NRTLP----DLSE-AGPFQGQHLGPGLRPS-DD--TKGPFG--RSLSTGRLTDLL-LK AAFGT--QAPDSGSTDSL-QEK-PMEI-------APSAGLGGNLHPGARAGGASSPAPVV FTVGSPPSGSTPPQGP----RARMFSVGS----SSSLSSAGSSSA---R--------HLA PGACS----------EA-VPEV--PGHCCTFADPVAANLEGAVTFEAPDLPEETLME--Q EHTEILHSLRFT--LVFVQHVLEIAALKGSAS--EAAG--GPEYQLQESVVADQISMLSR EWGFAEQLVLYLKVAELLSSGLQTAIDQIRAGKLCLS--ST------------------- -VKQ-VVRKLNELYKASVVSCQGLSLRLQR-------FFLDKQRLL---DRIQSVTAEKL IFSHAVQMVQSAALDEMFHRREDCV-QRYHKALLLMEGLQHILT---------------- ------------------------------------------------------------ ------------------------------------------------D--QADVENIA- -KCKLCIERRLSALLTGICA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >P_pygmaeus_ENSPPYP00000005848 ------------------------------------------------------------ ------------------------------------------------------------ ---E---LKHENIVALYDFQEMANSVYLVME--YCNGGDLADYLHTMRTLSEDT------ ------------------IRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRR-AN -----------PNSIRVK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIM SQHYD-GKADLWSIGTIVYQCLTGKAPF-QAS-SPQDLRLFYEKNKTLVPTIPR--ETSA PLRQLLLALLQRNHKDRMDF--DEFFHHPFLDASPSVRKS-----PPVPVPSYPSSGSGS SSSSSSTSHLASPP---SL---------GEM-QQ---LQKTLTSPA-----DTAG--FLH -SSRDS--GG-SKD-SSCDTDDFVMVPAQFP-GDLVAE------------APSAKPPPDS LMCSGS----SLVASAGLESHGRTPSPSPPC--------------------------SSS PSPSGRAGPFSSSRC-------GASVPIPVPTQVQNYQRIERNLQS-------------- --PTQFQTP--R-----SSAVRRSGSTSPLGFARASPSPPAH--AEHGGV-LARKMSLG- GGRPYTPSPQ-------------------------------------------------- -----------------VGTIPERPGWSGTPSPQGAEMRG-------------------- ----------------------------------------------------GRSP---- RP---G------------------------------------------------------ ---------------------------SSAPE-HSTRTSG--L-GCRLHSAPNLSDLHI- -VRPKLPKPPT--------DPLGAVFS--------PPQASPPQPSHGLQSCRNLRGSPKL PDFLQRNP--LPPILGSPTK-AVPSFD---------FPKTPSSQNLLALLARQGVVMTPP R-NRTLP----DLSE-VGPFHGQPLGPGLRPG-ED--PKGPFG--RSFSTSRLTDLL-LK AAFGT--QAPDPGSTESL-QEK-PMEI-------APSAGFGGSLHPGARAGGASSPSPVV FTVGSPPSGSTPPQGP----HTRMFSVGS----TGS----AGSSA---R--------HLV PGACS----------EAPAPELPAPGHGCSFADPIAVNLEGAVTFEAPDLPEETLME--- ------------------------------------------------------------ ---FAEQLVLFMKVAELLSSGLQTAIDQIRAGKLCLS--ST------------------- -VKQ-VVRRLNELYKASVVSCQGLSLRLQR-------FFLDKQRLL---DRIHSITAERL IFSHAVQMVQSAALDEMFQHREGCV-PRYHKALLLLEGLQHMLS---------------- ------------------------------------------------------------ ------------------------------------------------D--QADIENVA- -KCKLCIERRLSALLTGICA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >T_guttata_ENSTGUP00000008305 ------------------------------------------------------------ ------------------------------------------------------------ -------------------QELANSVYLVME--YCNGGDLADYLHTMRTLSEDT------ ------------------IRLFLQQIAGAMKMLHSKGIIHRDLKPQNILLSYAGGRK-SN -----------PNNIRIK----I-----ADFGFARYLQNNM-MAATLCGSPMYMAPEVIM SQHYD-AKADLWSIGTIIYQCLTGKAPF-QAS-SPQDLRLFYEKNKMLMPNIPR--ETSS HLRQLLLGLLQRNHKDRMDF--DEFFHHPFLDASASMKKS-----ASVPMPSYPSSGSGS SSSSSSTSHLASPP---SL---------GEMQQQL--QEKALASPT----QDSPG--FLH -GSKDSA-GSSSKN-SSCDTDDFVMVPAQFS-SDLAAE------------AAGGKPIQDS LMYSGS----SLVTSAGLESQGRTPSPSPPY--------------------------SSS PSPSGRPGQFSSSKY-------GHSVPIPVPTQIHNYRRIEQNLQS-------------- --PNPFSSP--R-----SATVRRSSSTSPLGFPKTGASPPYP--GEHGSMPSTKKLSFG- GAKPFMPSPQ-------------------------------------------------- -----------------VGTIPEQPSQTVTPSSLGAEVR--------------------- ----------------------------------------------------SRVP---- AA---G------------------------------------------------------ ---------------------------SLVPE-QSPR--G--M-GSRLHSAPNLSDLHS- -CRQKITKQHS--------DPLVAHFG--------HTPVSQPLQIHGLQHCRQLRSSPKL SEFMQRSP--LPTIVGSPTK-AVSPFE---------FPKTPSSQNLLTLLAHQGVMMTPT R-NKTLP----DLKE-MGHFHCQQTGLGLRPV-EE--IKGSIM--LSLSTGRLTDLL-LK AAFGA--QISEAGSSDSLNNEK-PMEIA------APSGAFGGTLHSGARA-GSASPSPVI FTVGSPPSGTTPPQTA----RTRMFSVGS----SSSLSSGGSFSG---R--------HLA VGAAG----------EA--LEGPS-SLRYTFADPITANLEGVVTFEAPELPEETLME--Q EHTDILRSLRFT--LAFLHYMMQSAALKGSYS--DMRGG-PIKYSADASVVADQIS-LSR EWSYAEQLVLYLKVAELLSSGLQMAIEQIKAGKLCLS--ST------------------- -VKQ-VVKKLNELYKSSVSSCHCLNMRLQR-------FFLDKQKLM---DRINSITAEKL IFSYAVQMVQSAALDEMFHHREDCA-QRYHKALLLMEGLLNIIT---------------- ------------------------------------------------------------ ------------------------------------------------E--QGDIENIS- -KCKLCIERRLSALLSGFCA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >M_mulatta_ENSMMUP00000020714 ------------------------------------------------------------ ------------------------------------------------------------ -------------------QEMANSVYLVME--YCNGGDLADYLHTMRTLSEDT------ ------------------IRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRR-AN -----------PNSIRVK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIM SQHYD-GKADLWSIGTIVYQCLTGKAPF-QAS-SPQDLRLFYEKNKTLVPIIPR--ETSA PLRQLLLALLQRNHKDRMDF--DEFFHHPFLDASPSVRKS-----PPVPVPSYPSSGSGS SSSSSSTSHLASPP---SL---------GEM-QQ---LQKTLTSPA-----DAAG--FLH -SSRDS--GG-SKD--SCDTDDFVMVPAQFP-GDLVAE------------APSAKPPPDS LMCSGS----SLVASAGLESHGRTPSPSPPC--------------------------SSS PSPSGRAGPFSSSRC-------GASVPIPVPTQVQNYQRIERNLQS-------------- --PTQFQTP--R-----SSAVRRSGSTSPLGFARASPSPPAH--AEHGGV-LARKMSVG- GGRPYTPSPQ-------------------------------------------------- -----------------VGTIPERPGWSGTPSPQGAEMRG-------------------- ----------------------------------------------------GRSP---- RP---G------------------------------------------------------ ---------------------------SSVPE-HSTRTSG--L-GCRLHSAPNLSDLHV- -VRPKLPKPPT--------DPLGAVFS--------PPQASPPQPSHGLQSCRNLRGSPKL PDFLQRNP--LPPILGSPTK-AVPSFD---------FPKTPSSQNLLALLARQGMVMAPP R-NRTLP----DLSE-VGPFHGQPLGPGLRPG-ED--PKGPFG--RSFSTSRLTDLL-LK AAFGT--QAPEPGSTESL-QEK-PMEI-------APSAGCGGSLHPGARAGGASSPSPVV FTVGSPPSGSTPPQGP----RTRMFSVGS----TGS----AGSSA---R--------HLV SGACS----------EAPAPELPAPGHSCSFADPIAANLEGAVTFEAPDLPEETLME--Q EHTEILRGLRFT--LLFVQHVLEIAALKGSAS--EAAG--GPEYQLQESVVADQISLLSR EWGFAEQLVLYLKVAELLSSGLQTAIDQIRAGKLCLS--ST------------------- -VKQ-VVRRLNELYKASVVSCQGLSLRLQR-------FFLDKQRLL---DRVHSITAERL IFSHAVQMVQSAALDEMFQHREGCV-PRYHKALLLLEGLQHMLS---------------- ------------------------------------------------------------ ------------------------------------------------D--QADIENVA- -KCKLCIERRLSALLTGICA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >P_troglodytes_ENSPTRP00000009595 ------------------------------------------------------------ ------------------------------------------------------------ --------------------EMANSVYLVME--YSNGGDLPDYLHAMRTLSEDT------ ------------------IRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRR-AN -----------PNSIRVK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIM SQHYD-GKADLWSIGTIVYQCLTGKAPF-QAS-SPQDLRLFYEKNKTLVPTIPR--ETSA PLRQLLLALLQRNHKDRMDF--DEFFHHPFLDASPSVRKS-----PPVPVPSYPSSGSGS SSSSSSTSHLASPP---SL---------GEM-QQ---LQKTLASPA-----DTAG--FLH -SSRDS--GG-SKD-SSCDTDDFVMVPAQFP-GDLVAE------------APSAKPPPDS LMCSGS----SLVASAGLESHGRTPSPSPPC--------------------------SSS PSPSGRAGPFSSSRC-------GASVPIPVPTQVQNYQRIERNLQS-------------- --PTQFQTP--R-----SSAIRRSGSTSPLGFARASPSPPAH--AEHGGV-LARKMSLG- GGRPYTPSPQ-------------------------------------------------- -----------------VGTIPERPGWSGTPSPQGAEMWG-------------------- ----------------------------------------------------GRSP---- RP---G------------------------------------------------------ ---------------------------SSAPE-HSTRTSG--L-GCRLHSAPNLSDLHV- -VRPKLPKPPT--------DPLGAVFS--------PPQASPPQPSHGLQSCRSLRGSPKL PDFLQRNP--LPPILGSPTK-AVPSFD---------FPKTPSSQNLLALLARQGVVMTPP R-NRTLP----DLSE-VGPFHGQPLGPGLRPG-ED--PKGPFG----------------- ------------------------------------------------------------ ---------------------------GP----TGS----ASSSA---R--------HLV PGPCS----------EAPAPELPAPGHGCSFADPIAANLEGAVTFEAPDLPEETLME--- -----------------------IAALKGSAS--EAAG--GPEYQLQESVVADQISLLSR EWGFAEQLVLYLKVAELLSSGLQTAIDQIRAGKLCLS--ST------------------- -VKQ-VVRRLNELYKASVVSCQGLSLRLQR-------FFLDKQRLL---DRIHSITAERL IFSHAVQMVQSAALDEMFQHREGCV-PRYHKALLLLEGLQHMLS---------------- ------------------------------------------------------------ ------------------------------------------------D--QADIENVT- -KCKLCIERRLSALLTGICA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >S_cerevisiae_YGL180W ---------------------------------------------MGDIKNKDHTTSVNH NLMASAGNYTAEKEIGKGSFATVYRGHLTSDKSQHVAIKEVSRAKLKNKKLLENLEIEIA ILKK---IKHPHIVGLIDCERTSTDFYLIME--YCALGDLTFLLKRRKELMENHPLLRTV FEKYPPPSENHNGLHRAFVLSYLQQLASALKFLRSKNLVHRDIKPQNLLLSTPLIGYHDS KSFHELGFVGIYNLPILK----I-----ADFGFARFLPNTS-LAETLCGSPLYMAPEILN YQKYN-AKADLWSVGTVVFEMCCGTPPF-RAS-NHLELFKKIKRAND-VITFPSYCNIEP ELKELICSLLTFDPAQRIGF--EEFFANKVVNEDLSSYE------LEDDLPELESKSKGI VESNMFVSEYLSKQ---PKSPNSNLAGHQSMADNP--AELSDALKN-------------- --------SNILTA-PAVKTDHTQAVDKKASNNKYHNS------------LVSDRSFE-- ------------------------------------------------------------ --------------REYVVVEKKSVEVNSLADEVAQAGFNPNPIKH-------------- ---------------------PTSTQNQNVLLNEQFSPNNQQ------------------ YFQNQGENP--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------RLLRATSSSSGGSD GSR----------------RPSLVDRRLSISSLNPSN---ALSRALGIASTRLFGGANQQ QQQQQI------------------------------TSSPPYSQTLLNSQLFHELTENII LRIDH----------------------------------------LQHPETLKLDNTNIV SILESL-----------------------------------------------AAKAFVV YSYAEVKFSQIVPLST-------------------------------------------- -------------------------------TLKGMANFENRRSMDSNAIAEEQDSDDAE EEDETLKKYKED-------CLSTKTFGKGRTL----------SATSQLSATFNKLPRSEM ILLCNEAIVLYMKALSILSKSMQVTSNWWYESQEKSC--SL------------------- -RVNVLVQWLREKFNECLEKADFLRLKINDLRFKHASEVAENQTLEEKGSSEEPVYLEKL LYDRALEISKMAAHMELKGENLYNCELAYATSLWMLETSLDDDD---------------- ------------------------------------------------------------ ---------------------FTNAYGDYPFKTNIHLKSNDVEDKEKYHSVLDENDRIII RKYIDSIANRLKILRQKMNHQN-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >P_pygmaeus_ENSPPYP00000014729 ---------------------------------------------M-EK----------- --------YHVLEMIGEGSFGRVYKGRRK-YSAQVVALKFIPKLGRSEKE-LRNLQREIE IMRG---LRHPNIVHMLDSFETDKEVVVVTD--YAE-GELFQILEDDGKLPEDQ------ ------------------VQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGG------ ---------------GIK----L-----CDFGFARAMSTNTMVLTSIKGTPLYMSPELVE ERPYD-HTADLWSVGCILYELAVGTPPF-YAT-SIFQLVSLILKDPV---RWPS--TISP CFKNFLQGLLTKDPRQRLSW--PDLLYHPFIAGHVTIITETAGPDLGTPFTSRLPPELQV LKDKQ-AHRLSPKG---NQ---------SRILTQA--YERMAEEAM-------------- --------QKKHQN-TGPALEQE-DKTSKVAPGTAPLP------------RLGATPQE-- ---------------------------------------------------------SS- -LLAGILA----SELKSSWAESGTGEAPSAPRENRTTPDCERAFPEE---------RPEV -------------------LGQRSTDAVDLEDEEPDSDNEWQHLL---------ETTEP- VPIQLKAPL--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------T-LLCNPDF----CQRIQSQLHEAGGQILKGIL EGASHILPAFR--------VLSSLLSSCSDSVALYSF---CREAGLPGLLLSLLRHSQES NSLQQQSW--YGTFLQDLMA----------------VIQAYFACTFNLE---RSQTSDSL QVFQEAANLFLDLLGKLLA---QPDDSEQTLRRDSLMCFTVLCEAMD-GNSRAISKAFYS SLLTTKQVVLDGLLHGLTVPQL-PVHT-------PPGAPQVSQPLREQSEDIPGAISSAL AAICTAPVGLPDCWDGKE--QVCWHLANQ----LTEDSSQLRPSLVSGLQHPILCLHLLK VLYSC-----------C--LVSERL---CRLLGQEPLALESLFMLVQGKVKVVD--W--E ESTEVTLYFLSL--LVFRLQNLPCG---MEKLGSDVATLFTHSHVVSLVSAAACLLGQLG Q----QGVTFDLQPMEWMAAATHALSAPAEVR-LTPP--GSCGFYDGLLILLLQLLTE-Q -GKASLIRDMSSSEMWTVLWHRFSMVLRLP----KEASAQEGELSLSSPPSPEP--DWTL ISPQGMAALLSLAMATFAQEPQLCLSCLSQHGSILMSILKHLLCPSFLNQLR-QAPHG-- --SEFLPVVVLSVCQLLCFPFALDMDADLLIGVLADLRDSEVAAHLLQVCCYHLPLTQVE LPISLLTRLALTDPTSLNQFVNT---VAASPRTIISFLSVALLSDQPLL--TSDLLSLLA HTARVLSPSHLSFIQELLAGSDESYQSLRSL-LGHPENSVRAHTYRLLGHLLQHSMALRG ALQSQSGLLSLLLLGLGDKDPVVRCSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDPQ AGIRRNVASALGNLGPEG--LGEELLQCQVPQRLLEMACGDPQPNVKEAALIALRSLQQE PGIRQVLVSLGASEKLALLSLGNQLLPHS---SPRPASAKHCRKLIHLLRPAHSM >M_mulatta_ENSMMUP00000008885 ---------------------------------------------M-EK----------- --------YHVLEMIGEGSFGRVYKGRRK-YSAQVVALKFIPKLGRSEKE-LRNLQREIE IMRG---LRHPNIVHMLDSFETDKEVVVVTD--YAE-GELFQILEDDGKLPEDQ------ ------------------VQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGG------ ---------------GIK----L-----CDFGFARAMSTNTMVLTSIKGTPLYMSPELVE ERPYD-HTADLWSVGCILYELAVGTPPF-YAT-SIFQLVSLILKDPV---RWPS--TISP CFKNFLQGLLTKDPRQRLSW--PDLLHHPFIAGRVTIITEPAGPDLGTPFTSRLPPELQV LKDEQ-AHRLAPKG---NQ---------SRILTQA--YKRMAEEAK-------------- --------QKKHQN-TGPALEQE-DKTSKVAPGTAPLP------------RLGATPQE-- ---------------------------------------------------------SS- -LLAGILA----SEMKSSWVESETGEAPPAPRENWTTPDCGQAFPEE---------RPEV -------------------LGQRGTDAVDLENEEPDSDNEWQHLL---------ETTEP- VPVQLKAPL--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------T-LLCNPDF----CQRIQSQLHEAGGQILKGIL EGASHILPAFR--------VLSSLLSSCSDSVALYSF---CREAGLPGLPLSLLRHSQES NSLQQQSW--YGTFLRDLMA----------------VIQAYFACTFNLE---RSQTGDSL QVFQEAANLFLDLLGKLLA---QPDDSEQTLRRDSLMCFTVLCEAMD-GNSRAISKAFYS SLLTTQQVVLDGLLHGLTVPQL-PVHT-------PPGAPQVSQPLREQSEDLPGAISSAL AAICTAPVGLPDCWDAKE--QVCWHLANQ----LTEDSSQLRPSLISGLQHPILCLHLLK VLYSC-----------C--LVSERL---CRLLGQEPLALESLFVLVQGKVKVVD--W--E ESTEVTLYFLSL--LVFRLQNLPCG---MEKLGSDVATLFTHSHVVSLVSAAACLLGQLG Q----QGVTFDLQPMEWMAAATHALSAPAEVR-LTPP--GSCGFYDGLLILLLQLLTE-Q -GKAGLIRDVASSEMWTVLWHRFSTVLRLP----KEASAQEGELLLSNPPSPEP--DWTL ISPQGMAALLSLAMATFTQEPQLCLSCLSQHGSILMSILKHLLCPSFLNQLR-HAPHG-- --SEFLPVVVLSVCQLLCFPFALDVDADLLIDILADLRDSEVAAHLLQVCCYHLPLTQVE LPISLLTRLALTDPTSLNQFVNT---VAASPRTIVSFLSVALLSDQPLL--TSDLLSLLA HTARVLSPSYLSFIQELLAGSDESYRPLRSF-LGHPENSVRAHTYRLLGHLLQHSMALRG ALQSQSGLLSLLLLGLGDKDPVVRCSASFAVGNATYQAGPLGPALAVAVPSMTQLLGDPQ AGIRRNVASALGNLGPEG--LEEELLQCQVPQRLLEMACGDPQPNVKEAALIALRSLQQE PGIHQVLVSLGASEKLALLSLGNQSLPHS---SPRPASAKHCRKLIHLLRPTHSM >P_troglodytes_ENSPTRP00000022091 ---------------------------------------------M-EK----------- --------YHVLEMIGEGSFGRVYKGRRK-YSAQVVALKFIPKLGRSEKE-LRNLQREIE IMRG---LRHPNIVHMLDSFETDKEVVVVTD--YAE-GELFQILEDDGKLPEDQ------ ------------------VQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGG------ ---------------GIK----L-----CDFGFARAMSTNTMVLTSIKGTPLYMSPELVE ERPYD-HTADLWSVGCILYELAVGTPPF-YAT-SIFQLVSLILKDPV---RWPS--TISP CFKNFLQGLLTKDPRQRLSW--PDLLYHPFIAGHVTIITESAGPDLGTPFTSRLPPELQV LKDEQ-AHRLAPKG---NQ---------SRILTQA--YKRMAEEAM-------------- --------QKKHQN-TGPALEQE-DKTSKVAPGTAPLP------------RLGATPQE-- ---------------------------------------------------------SS- -LLAGILA----SELKSSWAESGTGEVPSAPRENRTTPDCERAFPEE---------RPEV -------------------LGQRSTDVVDLENEEPDSDNEWQHLL---------ETTEP- VPIQLKAPL--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------T-LLCNPDF----CQRIQSQLHEAGGQILKGIL EGASHILPAFR--------VLSSLLSSCSDSVALYSF---CREAGLPGLLLSLLRHSQES NSLQQQSW--YGTFLRDLMA----------------VIQAYFACTFNLE---RSQTNDSL QVFQEAANLFLDLLGKLLA---QPDDSEQTLRRDSLMCFTVLCEAMD-GNSRAISKAFYS SLLTTQQVVLDGLLHGLTVPQL-PVHT-------PPGAPQVSQPLREQSEDIPGAISSAL AAICTAPVGLPDCWDAKE--QVCWHLANQ----LTEDSSQLRPSLISGLQHPILCLHLLK VLYSC-----------C--LVSEGL---CRLLGQEPLALESLFMLIQGKVKVVD--W--E ESTEVTLYFLSL--LVFRLQNLPCG---MEKLGSDVATLFTHSHVVSLVSAAACLLGQLG Q----QGVTFDLQPMEWMAAATHALSAPAEVR-LTPP--GSCGFYDGLLILLLQLLTE-Q -GKASLIRDMCSSEMWTVLWHRFSMVLRLP----EEASAQEGELSLSSPPSPEP--DWTL ISPQGMAALLSLAMATFTQEPQLCLSCLSQHGSILMSILKHLLCPSFLNQLR-QAPHG-- --SEFLPVVVLSVCQLLCFPFALDMDADLLIGVLADLRDSEVAAHLLQVCCYHLPLMQVE LPISLLTRLALMDPTSLNQFVNT---VSASPRTIVSFLSVALLSDQPLL--TSDLLSLLA HTARVLSPSHLSFIQELLAGSDESYRPLRSL-MGHPENSVRAHTHR-VGHLLQHSMALR- ----------------GDKDPFVRCSASFAVGNAAYQAGLLRPALAAAVPSMTQLLGDPQ AGIRRNVASALGNLGPEG--LGEELLQCEVPQRLLEMACGDPQPNVKEAALIALRSLQQE PGIHQVLVSLGASEKLSLLSLGNQSLPHS---SPRPASAKHCRKLIHLLRPAHSM >H_sapiens_ENSP00000295709 ---------------------------------------------M-EK----------- --------YHVLEMIGEGSFGRVYKGRRK-YSAQVVALKFIPKLGRSEKE-LRNLQREIE IMRG---LRHPNIVHMLDSFETDKEVVVVTD--YAE-GELFQILEDDGKLPEDQ------ ------------------VQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGG------ ---------------GIK----L-----CDFGFARAMSTNTMVLTSIKGTPLYMSPELVE ERPYD-HTADLWSVGCILYELAVGTPPF-YAT-SIFQLVSLILKDPV---RWPS--TISP CFKNFLQGLLTKDPRQRLSW--PDLLYHPFIAGHVTIITEPAGPDLGTPFTSRLPPELQV LKDEQ-AHRLAPKG---NQ---------SRILTQA--YKRMAEEAM-------------- --------QKKHQN-TGPALEQE-DKTSKVAPGTAPLP------------RLGATPQE-- ---------------------------------------------------------SS- -LLAGILA----SELKSSWAKSGTGEVPSAPRENRTTPDCERAFPEE---------RPEV -------------------LGQRSTDVVDLENEEPDSDNEWQHLL---------ETTEP- VPIQLKAPL--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------T-LLCNPDF----CQRIQSQLHEAGGQILKGIL EGASHILPAFR--------VLSSLLSSCSDSVALYSF---CREAGLPGLLLSLLRHSQES NSLQQQSW--YGTFLQDLMA----------------VIQAYFACTFNLE---RSQTSDSL QVFQEAANLFLDLLGKLLA---QPDDSEQTLRRDSLMCFTVLCEAMD-GNSRAISKAFYS SLLTTQQVVLDGLLHGLTVPQL-PVHT-------PQGAPQVSQPLREQSEDIPGAISSAL AAICTAPVGLPDCWDAKE--QVCWHLANQ----LTEDSSQLRPSLISGLQHPILCLHLLK VLYSC-----------C--LVSEGL---CRLLGQEPLALESLFMLIQGKVKVVD--W--E ESTEVTLYFLSL--LVFRLQNLPCG---MEKLGSDVATLFTHSHVVSLVSAAACLLGQLG Q----QGVTFDLQPMEWMAAATHALSAPAEVR-LTPP--GSCGFYDGLLILLLQLLTE-Q -GKASLIRDMSSSEMWTVLWHRFSMVLRLP----EEASAQEGELSLSSPPSPEP--DWTL ISPQGMAALLSLAMATFTQEPQLCLSCLSQHGSILMSILKHLLCPSFLNQLR-QAPHG-- --SEFLPVVVLSVCQLLCFPFALDMDADLLIGVLADLRDSEVAAHLLQVCCYHLPLMQVE LPISLLTRLALMDPTSLNQFVNT---VSASPRTIVSFLSVALLSDQPLL--TSDLLSLLA HTARVLSPSHLSFIQELLAGSDESYRPLRSL-LGHPENSVRAHTYRLLGHLLQHSMALRG ALQSQSGLLSLLLLGLGDKDPVVRCSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDPQ AGIRRNVASALGNLGPEG--LGEELLQCEVPQRLLEMACGDPQPNVKEAALIALRSLQQE PGIHQVLVSLGASEKLSLLSLGNQSLPHS---SPRPASAKHCRKLIHLLRPAHSM >O_cuniculus_ENSOCUP00000001738 ---------------------------------------------M-EK----------- --------YHVLEMIGEGSFGRVYKGRKK-YSAQVVALKFIPKLGRSEKE-LKNLQREME IMRG---LRHPNIVHMLDSFETDKEVVVVTD--YAE-GELFQILEDDGKLPEDQ------ ------------------VQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGG------ ---------------GIK----L-----CDFGFARAMSTNTMVLTSIKGTPLYMSPELVE ERPYD-HTADLWSVGCILYELAVGTPPF-YTT-SIFQLVSLILKDPV---RWPS--TISP CFKNFLQGLLTKDPRQRLSW--PDLLHHPFIAGRVTIVTEPAGPDLGTPFTSRLPPELQV LKDEQ-AHRLAPKG---SQ---------SRILRQA--YKRMAEAAK-------------- --------QKKHQS-TGRAPEQE-DRTSQAAADTAPLP------------RPRGTPQE-- ---------------------------------------------------------AS- -LLAGILA----SEMKSSWAEWGPGEAPPAPRENRSTADGGQGFAEP---------RPEA -------------------VSPRSISAVKPENEEPDSDEEWQHLL---------ETLEP- VPIQLKAPL--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------T-LLCNPDF----CQHIQTQLHASGAQILKGSL EGASHILPALR--------VLSSLLSSCSDSAPLYSF---CREAGLPGLLLSLLRHSQES SSIQTQPW--YGAFVRDLMA----------------AMQAYFACTFNLD---RSQTGDXX XXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXCFTVLCEAMD-GNSQAISKAFYS SLLTTQRVVLDGLLHGLTMPQL-PFHT-------PPGAPQASQPLRDLSEDLPGAVSSAL AAVCTAPVGLPSCWEAKE--QVSWHLATQ----LIEDSSQLRPSLVSGLQHPILCLSLLK VLYSC-----------C--HVSERL---CRLLGQEPLALESLSLVVQGKVKAAD--Q--E ESTEVALYLLAL--LVFRLQDLPCG---MEKLGGEVATLFTHSHVVSVVSAAACLLGQLG Q----QGVAFELQPAEWMAAATHALSAPAEXX-XXXX--XXXXXXXXXXXXXXXXXXX-Q -GKARLIRDVAGSELWTILWHRFSMALRLP----EEVPTLEEELLLSVPPSPEP--DWTL ISPQGMAALLSLAMATFTQEPQLCLSHLSQRGNILMSTLKHLLSPNFLHHLG-QAPHG-- --PEFLPVVVLSVCQLLCFPFSLDVDADLLVGILADLRDSEVAAHLLQVCCHRLPXXXXX XXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXVLVSLRASDKLALLSLGNQ-LPHS---SARPASARHCRKLIQLLRPTHDT >B_taurus_ENSBTAP00000038069 ---------------------------------------------M-EK----------- --------YHVLEMIGEGSFGRVYKGRRK-YSAQVVALKFIPKLGRSEKE-LRNLQREIE IMRG---LRHPNIVHMLDSFETDKEVVVVTD--YAE-GELFQILEDDGKLPEDQ------ ------------------VQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGG------ ---------------GIK----L-----CDFGFARAMSTNTMVLTSIKGTPLYMSPELVE ERPYD-HTADLWSVGCILYELAVGTPPF-YTT-SIFQLVSLILKDPV---RWPP--TISP CFKNFLQGLLTKDPRQRLSW--PDLLHHPFIAGRVTILTEPAGPDFGTPFTSRLPPELQV LKDQQ-AHRLAPKG---NR---------SHILRQA--CKRMAEEAK-------------- --------QKKHQN-TEPPLEQE-DRTSKVAPGTAPLP------------KLKDTPQE-- ---------------------------------------------------------PG- -LLTGVVA----SEMKSSWAEWGAGEAPPAPRENWITQDCEQVFPEL---------RPEV -------------------KGQQSLDAVDLENEEQDSDDEWQYLL---------ETTEP- VPIQLKAPL--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------T-LLCNPDF----CQRIQSQLHEAGEQILKGAL EGAPCILPALR--------VLSSLLSSCSDSVPLYSF---CREAGLPGLLLSLLKHSQES NSIQQQCW--YGAFVQDLVA----------------VIQAYFACTFNLE---RSQTGDSL QVFQEAASLFLDLLGKLLA---QPDDSEQALRRDILMCFTVLCEAMD-GNSWTVSKAFYS SLLTTHRAVLDGLLYGLTAPQL-PFHS-------PPGAPQVSQPLREQSEDLPGAISSVL AAMCTAPVGLPGCWEAKE--QIAQHLADQ----LTKDSNHLRSSLISALQHPILCLPLLK VLYSC-----------C--HVSERL---CHLLGQEPLALESLLNLAQGKVKVVD--R--E ESTEVTLYLLSL--LVLRLQDLPCG---MEKLGSEIATVFTHSHVVSLVSAAACLLGQLG Q----QGVTFDLQPGEWIAAATHALSAPAEVR-LTPP--GGCGFYDGLLILLLQLLTQ-Q -GKGNPIRDMASSEMWTVLWHRFFMALRLP----EEASTQEEEVSLSSPQSPEP--DWTL ISPQGMAALLSLAMATFTQEPQLCLSHLSQRGSILMSTLKHLLSPSFLHHLG-QAPQG-- --SEFLPVVVLSVCQLLCFPFALDVDADLLEGVLADLTDSEVTAHLLQVCCHHLPLTQVE LPISLLTRLALSDPAFLNQFVNT---VVASPRTTVSFLSTALLGDQPLL--TSDLLSLLA HTARLLSPSHLSFIHELLAGSDESYRPLRSL-LSHPETSVRARTYGLLGHLLQHSMALRG ALQSQAGLLNLLLLGLGDKDPAVRRGASFAVGNAAYQAGPLGPALAAAVPGMTQLLEDPQ AGIRRNAVSALGNLGPEG--LGEELLQCQVPQRLLEMACGDPQPNVKEAALVALRSLRQE PCIHQVLVSLGASEKLALLSLGNQLLPHS---SPRPASAKHCRKLIHLLRPTHST >C_familiaris_ENSCAFP00000021994 ---------------------------------------------M-EK----------- --------YHVLEMIGEGSFGRVYKGRRK-YSAQVVALKFIPKLGRSEKE-LRNLQREIE IMRG---LRHPNIVHMLDSFETDKEVVVVTD--YAE-GELFQILEDDGKLPEDQ------ ------------------VQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGG------ ---------------GIK----L-----CDFGFARAMSTNTMVLTSIKGTPLYMSPELVE ERPYD-HTADLWSVGCILYELAVGTPPF-YTT-SIFQLVSLILKDPV---RWPT--TISP CFKSFLQGLLTKDPRQRLSW--PDLLHHPFIAGRVTIITEPGGSDLGTPFTSHLPPELQV LKEQQ-VHRLAPKG---NR---------SRILRLA--CKRMAEEAK-------------- --------RKKHQN-TGPALEQE-DRTSKMASGTAPLP------------RLRATPQE-- ---------------------------------------------------------PG- -LIAGILA----SEMKSSWAEWGAGETPPAPRENQITQDCEQADPEL---------RPEV -------------------VGQQSIDAVDLENEEPDSDDEWQHLL---------KTGEP- VPIQLKAPL--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------T-LLCNPDF----CQRIQGQLHEAGGQILKDVP EDASHILPALR--------VLSSLLSSCSDSVPLYSF---CREAGLPGLLLSLLRHSQES NSIQQQCW--YGTFLRDLMA----------------VIQAYFACTFNLE---RSQTGDSL QVFQEAANLFLDQLGKLLA---QPDDSKQTLRRDSLMCFTVLCEAMD-GNSWTISKAFYS SLLTTQRAVLDGLLHGLTVPQL-SFHT-------PPGAPQVSQPLREQSEDLPGAMSSAL AAICTAPVGLPSCWEAKE--QISRHLANQ----LSEDSNQLRPSLISGLQHPILCLHLLK VLYSC-----------C--HISERL---CHLLGQEPLALESLLMLVQGKVKVVD--W--E ESTEVALYLLSL--LVLQLQDLPPG---MEKLGNEIATLFTHSHIVSLVSAAACLLGQLG Q----QGVTFDLQPVEWIAAASHALSAPAEVR-LIPP--GCCGFYDGLLILLLQLLTQ-P -GKGSLLRDVADSEIWTVLWHRFSMALRLP----EEVSPQEEEPSLSRPQSPEP--DWTL ISPQGMAALLSLAVATFTQEPQLCLSHLSQRGSILMSTLKHLLSPSFLRQLG-RAPQG-- --AEFLPVVVLSVCQLLCFPFALDVDADLFRGVLADFVDSEVAAHLLQVCCHHLPLPQVE LPVSLLTRLALTDLTSLNQFVNT---VAASPRTVISFLSVALLGDQPLL--TSDLLSLLA HTARVLSPSHLSFIQELLAGSDESYRPLRSL-LGHPEHSVRARTYGLLGHLLQHSMALRG ALQSQAGLLNLLLLGLGDKDPAVRRSASFAVGNAAYQAGPLGPALAAAVPGMTQLLEDPQ AGIRRNAVSALGNLGPEG--LGAELLQYQVPQRLLEMACGDPQLNVKEAALIALRSLRQE PCIHQVLVSLGASERLAMLSLGNQLLVHS---SPRPASARHCRKLIHLLRPTHST >G_gallus_ENSGALP00000018526 ---------------------------------------------M-ER----------- --------YHVLEVIGEGSFGRVYKGRRR-CSAQVVALKFIPKVGRSEKE-LKNLQREIE IMRG---LHHPNIIQMLDSFETDKEVVMVTD--YAE-GELFQILEDDGSLPEDQ------ ------------------VQTIAAQLVSALYYLHSHRILHRDMKPQNILLGKDG------ ---------------VIK----L-----CDFGFARAMSIHTMVLTSIKGTPLYMSPELVE ERPYD-HTADLWSVGCILYELFMGTPPF-YTS-SIFQLVSLIVKDPV---KWPK--AISP AFKSFLQGLLMKDPHQRLSW--PELLSHPFVAGRVTVIDDTEEHGISNPFTTKLSPELQA LKEQQ-AHSLAPRS---GQ---------SRILRKA--RQKMAEEAQ-------------- --------KKVEKS-VGFS-----GLHPMVMSKEGLLN------------GTEAALEE-- ---------------------------------------------------------EVE LPPSFKEKKSGVLQGKNSMAEWQLKEPPPSPREHSITQDYEREFPQPEAPLQLAVGKAEL -------------------RGRQSIKAVDLESEEQESDEEWQHLI---------EATEP- LAMQLSTPL--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------S-LLRDPAF----RHRVQARLAESAQQVLEGML EGASHLRPVLR--------VVGNLLATRCDSELLNLF---CQELSLPLSLLHLAKQMLES GSTRQQPW--CITVLTDLIM----------------VTTVYFSSECNLE---KSG-QDSL QTIQESANHFLALLPDLLA---EPADSEMRLCQQSLLCFTLLCESLD-AMCPSISAPFYA SLREENEPLLDRLLQGLISEQP-ALQG-------LPGATMEAKSAHDQRQCVADLCTAAL AAACSIPLAQSSCRETKQ--QVAQEIAGK----LMDGECQQLGKLLGRLEHPNCSLNVLK ILYTC-----------C--YASPSL---CQHLGRSQQVWDFLMQLSKGKVPMAEVTR--K VACEASLYLLAL--LTLQPQASPSR---LEEVVTLALDVLTQSPVISVVGAAAFLLTQLD Q----RGVPVALQGKEILPAVTNALMEPAELH-FSLP--MGAGLYDGIIFLLLKLLAQ-- -EDVAVEQSFAASELWNVVWHCVPAVLCMG----SSGAALEGDSPGAGPPVAEP--DWSL LSPQGTLLFLSLALLIFTRETHRCLPQLTQSRGVFMVMLKTLLSPRFLACLA-QTQAGEN GEAELIPAVVIQACQLLCFPFALDVDEDTIALVIEAVRDSQIPPQLLQVCCHHLPFSDTE LPMSLLCRLVVSDEQVTDQIAR----EAATSEHIIAYLSTVLFSGSLTL--TTDLLSLLT HVART-CPEHLPFLQRILGGSDMSYQALTHL-LSHQEHPIRAKTCNLLGNLLRHSHGFPQ VLQNQPGLLESLLVCLADEDEAVRKAASFAVGNAAYHESSPAGTLGRAVPRLTQLLSDRQ AKTRCNAASALGNLGRRSAELGELLIESGAPRILLEMACRDPQASVREGALMALRAVSQH PGIQQVLLSLRATDQLAALAGGDSW--TTAGGSPRPSSARHCQKLIRLLTPLQST >R_norvegicus_ENSRNOP00000022839 ---------------------------------------------M-EK----------- --------YHVLEMIGEGSFGRVYKGRKK-YSAQVVALKFIPKLGRSEKE-LRNLQREIE IMRG---LWHPNIVHMLDSFETDKEVVVVTD--YAE-GELFQILEDDGKLPEEQ------ ------------------VQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGG------ ---------------GIK----L-----CDFGFARAMSTNTMVLTSIKGTPLYMSPELVE ERPYD-HTADLWSVGCILYELAVGTPPF-YTT-SIFQLVSLILKDPV---RWPS--TITS CFKNFLQGLLTKDPRQRLSW--PDLLHHPFIAGRVTIITEPAGSNLGTPFTSRLPPELQV LKDEQ-AHRLAPKG---NQ---------SRILRQA--CKRMAEEAK-------------- --------QKEDQN-TGSTLDQE-ARLSKVTPSTAPVP------------GLKATPQE-- ---------------------------------------------------------SS- -LLAGLLA----SEMKNNWEDWGAGEAPPTPRENHITLECEQAFPEL---------RPET -------------------MGRRSTDAVDPENEEPDSDDEWQRLL---------ETMEP- VPVQLKSPL--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------T-LLCNPDF----CQHIQSQLRGTGEQILKGVL DGASHLLPALR--------ILSSLLSSCSDSVLLYSF---CQEVGLPELPLSLLRYSQES SSIQQQPW--YGAFLRELVA----------------VVQAYFSCTFNLE---RSQTGDSL QVFEEAASLFLDLLGKLLA---QPDDSEPTFRRDSLMCFAVLCEAVD-GNSRAISKAFYA SLLTTQRAVLDGLLHGLTVPQL-PFHT-------PPGAPQVSQPLREQSEDVPGAISSAL AAMCTAPVGLPSCWDAKE--QVSWHLANQ----LTEDSSQLRPSLISGLRHHILCLHLLK VLYSC-----------C--YISERL---CHILGQEPLALESLLMLVQGKVKVAD--W--E ESTEVALYLLSL--LVFRLQDLPSG---MEKLGSEVATLFTHSHIVSLVNAAACLLGQLG Q----QGVTFDLQPREWIAAAAHALSAPAEVR-LTPP--CSCGFYDGLLVLLLQLLTQVQ MGKPGLIRDVAGSEVWTILWHRFSMALRLS----EEVSAQEDDLSLSSPPSLEP--DWTL ISPQGMAALLSLAMAIFTQEPQLCLSHLSQHGSVLMLTLKHLLSPSFLHRLS-QAPQG-- --SEFLPVVVLSVCKLLCFPFALDVDADLLGGILADLRASEVAVYLLQVCCHHLPLFQAE LPIGLLTRLALMDPTSLKQFVNT---VATSSRAIISFLSVVLLCDQPLM--VSDLLSLLT HTTRILSPSHLSFIQELLSGSDESYRPLRSL-LGHSENAVRVRTYRLLGHLLQHSMALRG ALQSQSGLLNLLLLGLGDKDPAVRRSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDAQ DAIRRNAASALGNLGPEG--LGKELLKCQVPQRLLEMACGDPQPTVKEAALIALRSLRQE PCIHQVLVSLGASEKLTLLSLGHQLLPSS---NSRPTSARHCRKLIHLLRPTHST >E_caballus_ENSECAP00000008449 ---------------------------------------------M-EK----------- --------YHVLEMIGEGSFGRVYKGRRK-YSAQVVALKFIPKLGRSEKE-LRNLQREIE IMRG---LRHPNIVHMLDSFETDKEVVVVTD--YAE-GELFQILEDDGKLPEDQ------ ------------------VQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGG------ ---------------GIK----L-----CDFGFARAMSTNTMVLTSIKGTPLYMSPELVE ERPYD-HTADLWSVGCILYELAVGTPPF-YTT-SIFQLVSLILKDPV---RWPP--TISP CFKNFLQGLLTKDPRQRLSW--PDLLHHPFIAGHVTIITEPAGSDLGTPFTSRLPPELQV LKDQQ-AHRLVPKG---NQ---------FRILRQA--CKRMAEELK-------------- --------QKRHQN-TGPALEQE-DRTSKVASGTASPP------------RLRATPQE-- ---------------------------------------------------------SG- -LLAGILA----SEMKSSWAECGAGEDPPAPRENWTTQDCERAFPEL---------RPEV -------------------MGQQSIDAVDLENEEPDSDDEWKHLL---------ETSKP- MPIQLKAPL--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------T-LLCNPDF----CQRIQAQLHEAAGQILKGML EGASQILPALR--------VLSSLLSSCSDSVPLYSF---CREAGLPGLLLSLLRHSQEN NSIQQQCW--CGTFLQDLMA----------------VIQAYFACTFNLE---RSQTGDSL QVFQEAANHFLDLLGKLLA---QPDDSEQNLWRDSLMCFIVLCEAMD-GNSWTVAKAFYC SLLTTQRAVLDGLLHGLTVLQL-PVHS-------PPGAPQVSQPLREQSADLPGALSSAL AAICTTPVGLPGCWKAKE--QITRHLANQ----LIEDSTQLRPSIISGLKHPILCLHLLK ILYSC-----------C--HISEHL---CHLLVQEPLALESLLMLVRGKVKVVD--W--E ESAEVTLYLLSL--LVLRLQDLPSG---MEKLGGEIATVFTRSHVVSLVSAAACLLGQLG Q----QGVPFDLQPVEWIAAATHALSAPAEVR-LTPP--DGCGFYDGLFILLLQLLSQ-E -GKGSLIREVASSEMWTVLWQRFSMALRLP----EEVSAQEEELSLCSPQSPGP--DWTL ISPQGMAALLSLAVASFTQEPQLCLSHLSQRGSILMSTLKHLLSPSFLHQLG-QAPHG-- --SEFLPVMVLSVCQLLCFPFALDVDADLLVGVLADLTNSEVTAHLLQVCCHHLPLPQVE LPISLLTHLALMDSTSLNQFVNT---VAASPRSMISFLSIALLGDQPLL--TSDLLSLLA HTVRVLSPSHLSFIQELLAGSDESYRPLRS--WAHPENSVRARTYGLLGHLLQHSMALRG ALQ-QTGLLNLLLLGLGDKDPAVRRSASFAVGNAAYQAGPLGPALAAAVPGMTQLLGDPQ AGIRRNAASALGNLGPEG--LGEELLQCQVPQRLLEMACGDPQPNVKEAALIALRSLRQE PCIHQVLVSLGASEKLALLSLGNPSLPHS---SPRPASAKHCRKLIHLLRPTHST >M_musculus_ENSMUSP00000084430 ---------------------------------------------M-EK----------- --------YHVLEMIGEGSFGRVYKGRKK-YSAQVVALKFIPKLGRSEKE-LRNLQREIE IMRG---LWHPNIVHMLDSFETDKEVVVVTD--YAE-GELFQILEDDGKLPEDQ------ ------------------VQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGG------ ---------------GIK----L-----CDFGFARAMSTNTMVLTSIKGTPLYMSPELVE ERPYD-HTADLWSVGCILYELAVGTPPF-YTT-SIFQLVSLILKDPV---RWPS--TISS CFKNFLQGLLTKDPRQRLSW--PDLLHHPFIAGRVTIITEPAGSDLGTPFTSRLPPELQV LKDEQ-AHRLAPKG---NQ---------SRILRQA--CKLMAEEAK-------------- --------QKEDQN-AGSALEQE-DGLCKVTPSTAPVP------------GLKATPQE-- ---------------------------------------------------------SS- -LLAGILA----SEMKNNWEDWGAGEAPRTSRENHINLECEQGFPEP---------RPEA -------------------MGRQSTDVVDPENEEPDSDDEWQRLL---------ETSEP- GPVQLKSPL--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------T-LLCNPDF----CQRIQSQLRGTGEQILKGVL DGVSHLLPVLR--------ILSSLLSSCNDSVLLYSF---CQEAGLPELPLSLLRYSQES SSIQQQPW--YGALLRDLVA----------------VVQAYFSCTFNLE---RSQTGDSL QVFQEAASLFLDLLGKLLA---QSDDSEQTFRRDSLMCFAVLCEAVD-GNSWAVSKAFYS SLLTTQRAVLDGLLHGLTVPQL-PFHT-------PPGAPQVSQPLREQSEDVPGAISSAL AAMCTAPVGLPSCWDAKE--QVSWHLANQ----LTEDSSQLRPSLISGLRHHVLCLHLLK VLYAC-----------C--YISERL---CHILGQEPLALESLLMLVQGKVKVAD--W--E ESTEVALYLLSL--LVFRLQDLPSG---MEKLGSEVATLFTHSHVVSLVNAAACLLGQLG Q----QGVTFDLQPREWIAAAAHALSAPAEVR-LTPP--YSCGFYDGLLILLLQLLMQVQ -GKPGLIRDVVGSEVWTILWHRFSMALRLP----EEVSAQEDDLLLSSPSSLEP--DWTL ISPQGMAALLSLAMAIFTQESQLCLSHLSQHGSVLMLTLKHLLSPSFLHHLS-QAPQG-- --PEFLPVVVLSVCKLLCFPFALDVDADLLVGVLADLRASEVVVCLLQVCCHHLSLLQAE LPIGLLTRLALTDSASLKQFVNT---VATSSRAIISFLSVVLLSDQPLM--ISDLLSLLT HTARILSPSHLSFIQELLSGSDESYRPLRSL-LGHSENTVRVRAYGLLGHLLQHSMALRG ALQSQSGLLNLLLLGLGDKDPAVRRSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDAQ DGIRRNAASALGNLGPEG--LGKELLKCQVPQRLLEMACGDPQPTVKEAALIALRSLQQE SCIHQVLVSLGASEKLALLSLGNQLLPNS---SNRPASVRHCRKLIQLLRPTHST >M_domestica_ENSMODP00000019211 -----------------------------LISSSSSRLRDPGALMM-EK----------- --------YHVLEMIGEGSFGRVYKGRKK-YSAQVVALKFIPKLGRSDKE-LRNLHREIE IMRG---LRHPNIIQMLDSFETDKEVVVVTD--YAE-GELFQILEDDGKLPEDQ------ ------------------VQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGG------ ---------------GIK----L-----CDFGFARAMSTNTMVLTSIKGTPLYMSPELVE ERPYD-HTADLWSVGCILYELAVGTPPF-YTT-SIFQLVSLILKDPV---RWPP--TISQ CFKSFLQGLLTKDPRQRLSW--PELLYHPFIAGRVTMTSETVTSDLGTPFTSRLPLELQA LKEEQ-TNWLTPKG---GQ---------SRILRQA--RKRMAEDTR-------------- --------QKTHLN-PGTSLEQV-EKASKAVPVAALLP------------RLGATSQD-- ---------------------------------------------------------LD- -FLSRTPS----PEDKKDWAEWEASEPPQPTREPQVTQEYDQEFPEL---------KQEA ----------------------EESSVGTLEPEEPDSDSEWQHLL---------EPTAP- SDIQLKAPL--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------T-LLCNPDF----CQRVQNQLHGAGGQVLEGIL DGASRLLPTLR--------VVKSLLTTCSDSALLYAF---CREAGLPGLLLNLLRHSQSS VNIQQQPW--CGTFLRDLVA----------------TIQAYFAGNFNLE---KSQTSDSL HVFQEAANLFLNLLGKLLA---QPDDAEQTLRRDSLMCFTDLCKTMD-GSNLAISKSFYC SFLTTHKPVLDGLLHGMALPQL-PLHT-------PPGAPQVSQPLREQDEDLPRAFATAL AAICTLPVGLPGCWEAKE--QVSKHLADQ----LTDDSSQLRPYLFSSLQHPSLSLHLLK VLYAC-----------C--HVNENL---CRRLDQEPLALESLLLLVQGKVDVID--P--E ETAEATLHLLSL--LVLRLQVLPPG---VKKIGNELAVLFVHSPVVSLVSAAAGLLSQLS Q----QGVAFNLQPKEWIAAAAHALSAPAEL-----P--PGCFLF--------------Q -GGAEIVQDVANSELWTILWHRFFMTLRLS----EEVPTSEDKMSLPSQSVPEP--EWTL ISPQGITALLNVALAVFTQEPHLCLPYLIQHNSILMSTLKHLLSPIFLQQLG-QTQHG-- --SELLPAVVLPVCQLLCFPFAMDVDVDVLLNILADLRDSEVPAHLLQVCCRYLLLPQAE LPVSLLARLALTDSTTLNQFVAS---VAASPNT-ITFLSAALLGDQPLL--TSDILSLLA HAARAWPPTHLPFLQDLLAGPDESYWPLRCL-LGHPENPVRARAYGLLGHLLHQSTALRG ALQSQAGLLSLLLAGLRDKDPAVRRSASFAVGNAAYQAGPLAPALVPAVPRVTQLLGDPQ TGTRRNAASALGNLGPEG--LGEELLRCQVPHRLLETACGDPQPTVREAALIALRSLRQE PSIHQVLVSLDASEKLASLSSASPLPPHSSSGSPRPSSARHCKKLIHLLRPAHST >A_carolinensis_ENSACAP00000002909 ---------------------------------------------M-EQ----------- --------YHVLEMIGEGSFGRVYKGRRK-YTTKIVALKFIPKVGRSQKE-LKNLQREIE IMRG---LHHPNIVQMLDSFETDKEVVVVTD--YAE-GELFQILEDDGNLPEEQ------ ------------------VQIIASQLVSALYYLHSHRILHRDMKPQNILLGKGG------ ---------------VIK----L-----CDFGFARAMSIHTMVLTSIKGTPLYMSPELVE EKPYD-HTADLWSVGCILYELYVGTPPF-YTN-SIFQLVSLIIKDPV---KWPK--NMSL HFKSFLQGLLMKNPHERLSW--PELLYHPFIAGKVTVIDDTVDQGIVNPFTSKLPPDLQA LKEQQ-AHSLTPPS---GQ---------SKILRKA--RQKMAQEAR-------------- --------RKEMGK-PKASLKGEVSKESETYSRKACLA------------QTDSSRQH-- ---------------------------------------------------------QK- -LPGMEEH----LALGEKETEWEQKEPSSKLQENWITQDYEREFQEM---------KPES ---------------------RRSIDTVDLETEEMDSDEEWQHFI---------DATNS- THVHLSAPL--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------S-LLGDPAF----VQRIRVRLKDSGQQVLEGML EGASHLRPALH--------VISNLLGTCCDSDLLCSF---CNDIGLPQFLMQLVESILKS FNIKQQPW--HITLLTDLMA----------------VMTVFFASDFNRE---KDGKKQSL QAFQSSANHFLTLLPALLA---QPTDQEGRLREQSLVCFTHLCQSMD-NACPSISIPFYT SLLENHCPLLDTLCHGVSCEQI-IQEV-------PPKEARSKQ---HWNELMGAAFAKAL AASCVIPGRHTVCQKAKK--KISQYIAEK----LTEKENRLLASLILAVNHPASSLHGLK VLYAC-----------G--HVSQTL---CHHLA-TPEMLNSLICHLQGKVFIHS--Y--L CYKENCLVLFSL--LMLQLQFLPSQ----TYLIRNLGTACTHSIPNRRVSAAALLLTYFI Q----HGAAVKLRWEEALTAIATAFTESAEPC-LPPP--MGVGFYDGLLILLLHVLSEVC -GDVAMVREFAASELWGIVWHLFAMVLHMT----TQEPMLEGETSGAGQHAPEP--DWDL ISPQGTPFFLSLTLFVFTCEPHQCLLQMAQPNGLIMAVLNKLLDPDFLEQLH------ED GDLELVTTTVLQVCQVFCFAFAMDMDPEILEQILTNMKGSEIPAQLLQVCIHHLPCTKTE LPLSLLCRLVLSDEEIIEQVVG-----AATSQDAIDFLSSIFLSDQVHL--LADLLTLLT HIARA-SPSHLPFLEKLLSGS--TSQALSHL-LGHSECLVRARTCSLVGNLLRHGQEFPH ILQGQVGLLKSLLERLSDEDRHVRRSASFAVGNAAYQAGPFMQDLRKAVPCVVRLLGDPQ AKTRCNAASALGNLGWQSVELGDSLIQNKAPNILLDVACHDSQPAVQKAALIALRSMSHQ PRIRQVLVSLRACEKLEALTLDQFQ--NSAYSHPWPSSTQHCKKLIQLLQPSQSA >G_gorilla_ENSGGOP00000001881 ---------------------------------------------M-EK----------- --------YHVLEMIGEGSFGRVYKGRRK-YSAQXXXXXXXXXXXXXXXX-LRNLQREIE IMRG---LRHPNIVHMLDSFETDKEVVVVTD--YAE-GELFQILEDDGKLPEDQ------ ------------------VQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGG------ ---------------GIK----L-----CDFGFARAMSTNTMVLTSIKGTPLYMSPELVE ERPYD-HTADLWSVGCILYELAVGTPPF-YAT-SIFQLVSLILKDPV---RWPS--TISP CFKNFLQGLLTKDPRQRLSW--PDLLYHPFIAGRVTIITEPAGPDLGTPFTSRLPPELQV LKDEQ-AHRLAPKG---NQ---------SRILTQA--YKRMAEEAI-------------- --------QKKHQN-TGPALEQE-DKTSKVAPGTAPLP------------RLGATPQE-- ---------------------------------------------------------SS- -LLAGILA----SELKSSWAESGTGEVPSAPRENRTTPDCERAFPEE---------RPEV -------------------LGQQSTDVVDLENEXXXXXXXXXXXX---------XXXXX- XXXXXXXXX--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------X-XXXXXXX----XXXXXXXXXXXXXXILKGIL EGASHILPAFR--------VLSSLLSSCSDSVALYSF---CREAGLPGLLLSLLRHSQES NSLQQQSW--YGTFLQDLMA----------------VIQAYFACTFNLE---RSQTSDSL QVFQEAANLFLDLLGKLLA---QPDDSEQTLRRDSLMCFTVLCEAMD-GNSRAISKAFYS SLLTTQQVVLDGLLHGLTVPQL-PVHT-------PPGAPQVSQPLREQSEDIPGAISSAL AAICTAPVGLPDCWDAKE--QVCWHLANQ----LTEDSSQLRPSLISGLQHPILCLHLLK VLYSC-----------C--LVSEHL---CRLLGQEPLALESLFMLIQGKVKVVD--W--E ESTEVTLYFLSL--LVFRLQNLPCG---MEKLGSDVATLFTHSHVVSLVSAAACLLGQLG Q----QGVTFDLQPMEWMAAATHALSAPAEVR-LTPP--GSCGFYDGLLILLLQLLTE-Q -GKASLIRDMSSSEMWTVLWHRFSMVLRLP----EEASAQEGELSLSSPPSPEP--DWTL ISPQGMAALLSLAMATFTQEPQLCLSCLSQHGSILMSILKHLLCPSFLNQLC-QAPHG-- --SEFLPVVVLSVCQLLCFPFALDMDADLLIGVLADLRDSEVAAHLLQVCCYHLPLMQVE LPISLLTRLALMDPTSLNQFVNT---VSASPRTIVSFLSVALLSDQPLL--TSDLLSLLA HTARVLSPSHLSFIQELLAGSDESYRPLRSL-LGHPENSVRAHTYRLLGHLLQHSMALRG ALQSQSGLLSLLLLGLGDKDPVVRCSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDPQ AGIRCNVASALGNLGPEG--LGEELLQCEVPQRLLEMACGDPQPNVKEAALIALRSLQQE PGIHQVLVSLGASEKLALLSLGNQSLPHS---SPRPASAKHCRKLIHLLRPAHSM >G_aculeatus_ENSGACP00000012128 ---------------------------------------------M-VM--AESAQKPLI RGPVRVGFYDIERTLGKGNFAVVKLARHR-ITKTEVAIKIIDKTQLDAVN-LEKIYREVQ IMKM---LEHPHIIKLYQVMETKNMLYLVTE--YAKNGEIFDYLAKHGRLSELE------ ------------------ARRKFWQILSAVEYCHNRNIVHRDLKAENLLLDGHM------ ---------------NIK----I-----ADFGFGNFFQPGE-PLATWCGSPPYAAPEVFE GQQYEGPQLDIWSMGVVLYVLVCGALPF-DGP-TLPVLRQRVLEGRF---RIPY--FMTE DCEHLIRRMLVLDPSKRLSV--AQIKEHKWMALYAPVQRPVL---YQQPLPAEGEARVGE YSEQV-----------------------LRLMHSLGIDQNKTIESL-------------- --------QNKSYN-HFAAIYYLLVERLKAHRCSFPVE------------QRLDARQR-- ------------------------------------------------------------ --------------RPSTIAEQTVVKPSSGSAQVGLLPQGVRLLRS-------------- ------------------PAVPQASS-DGFTFPQSACLLEQNFLVED-VNTPKVNG---- CLLDPLPPP--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------TALRKSSTSSPSNMMETSIDEGIETEEPDTE DESPHLLSAHQ--------TARFGQRRHTLSEVSNQ----PGPSNQGKLFAIGHNPSMGS MDSDMGYD----------------------------MGSMQSDLGLLDDPPSLGEVVAAN STAAGIAPAPFLSARPANPAMAVLTSQHRETHNRSP---------VSFREGRRASDTSLT QGLVAFRQHLQNLARTKGILEL-------------------------------NKVQMLV EQMGSGEGASMGPLGPQQHLHNLLESASSHRVAQKQQQEGLALYQGGPHPPLLSRRQSLE TQYLT-------------------HRLQKANVLANSPASCQLFCKDT-RSLEQQLQEQRL NQKRMYLQQTQGMGLQVYFNQMQIAEGSYTTGGAALDPAASQGSPHGPPMSAAHQPQQQG GPQASPP----FSHPHSLSPLMEPDEGLV------------------------------- -------------YDPYTGHHHYAQ------------HPPPGSHLHHQLPHPLPHGASAG SLGFSFPVGCEQHAMGPFGEGVHQERYEFQLDPA----LLRPPAPGEAVARMLACPG--- ------------------------------------------------------------ ---------------------------------------------------QSDSLGLPE LQGSLLDSEMMETVDSQHGFVLVN------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >M_domestica_ENSMODP00000018106 ---------------------------------------------M-VM--ADGP-RHLQ RGPVRVGFYDIEGTLGKGNFAVVKLGRHR-ITKTEVAIKIIDKSQLDAVN-LEKIYREVQ IMKM---LDHPHIIKLYQVMETKSMLYLVTE--YAKNGEIFDYLANHGRLSESE------ ------------------ARRKFWQILSAVDYCHSRKIVHRDLKAENLLLDNNM------ ---------------NIK----I-----ADFGFGNFFKSGE-PLATWCGSPPYAAPEVFE GQQYEGPQLDIWSMGVVLYVLVCGALPF-DGP-TLPILRQRVLEGRF---RIPY--FMSE DCEHLIRRMLVLDPSKRLTI--AQIKEHKWMLVEVPIQRPVL---Y--PQEQENEPSLGE YNEQV-----------------------LRLMHSLGIDQQKTMESL-------------- --------QNKSYN-HFAAIYYLLVERLKSHRSSFPVD------------QRVDARQR-- ------------------------------------------------------------ --------------RPSTVAEQTVAKAQTVGPPMAIRSPNMRLMRS-------------- ------------------PILPQTSNVEVFSFPNSGCQADAAFMEEERVDTPKVNG---- CLLDPVPP---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------IMVRKGCQSLPSNMMETSIDEGIET-EGESE EDPSHSFDAFQ--------STRCGQRRHTLAEVTNQLVMMPG---TGKVFSVNDHPSLGS VDSE--YD----------------------------MGSIQRDLNFLEDNPSLKDIMLAN QPTHRLTP-PFISIRPANPAMQVLSSQKRETHNRSP---------VSFREGRRASDTSLT QGLVAFRQHLQNLARTKGILEL-------------------------------NKVQLLY EQMGSEAEPSLASAAPQ--LQDLVSSASQEE--ATQQQENASAFPNTVHPQ-LSRRQSLE TQYLQ-------------------HRLQKPNLLSKAQNTCQLYCKESPRSLEQQLQEHRL HQKRLFLQKQSQ--LQAYFNQMQIAESSYPRPNQQL-PLP-----HQ---------EQLS SPQAQSPQPPQFSLAQSLSPVLEPSSEQMQ------------------------------ -------------YDPFLSQYRKLQLQPLPSSQVPGSPPPLPSQLQQQPPQP---PAAPP PLPFSYQTRELPGAAPP--EPDYPAPCQYSMDPAQQSNVALPDCPRSSGPR--ESPS--- ------------------------------------------------------------ ---------------------------------------------------SYDPLALSE LPG-LFDCEMVEAVDPQPSGYVLCSRQEA------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >C_intestinalis_ENSCINP00000014205 -------------------------------------------LNM-DN----------- --------YQVLELIGEGSFGKVYKGRKK-YTGSTVALKFIPKAGKSDKD-LRNLRKEIE IMSD---LQHPNIIQLLDNFETEQEVVVVTE--YAE-GELFQILEDDGKLSEDQ------ ------------------VQEIASQLVSALYYLHSHRILHRDMKPQNILIGKGG------ ---------------VVK----L-----CDFGFARAMSMNTLVLTSIKGTPLYMSPELVE EKPYD-HNADLWSLGCILYELFVGKPPF-YTN-SIFQLVSLIIKDDI---KWLK--SMSD NFRSFLKGLLTKNPVKRLTW--PFLLKHPFIV---------------------------Q AKEKI-AAQVSSKG---GG---------SKILRKA--RQKMAAAEK-------------- --------EKKSLK-S----------------------------------ETHKTEEN-- ------------------------------------------------------------ --------KSKNQSNKSKLPQIQTKTKKPAKREVSSATKSKQIEKE-------------- -------------------KLPNMKQLSLQDQSVEDSDDDWQEII---------DATDP- GNMQLTTPM--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------TLLSDAEF----RRKILEEIKVAKDKALGGKL SGASTFRSIIK--------VMTNLLATKCDADLLWRF---CQELEIPNQFLEMLDHIWKN ETQKKRSW--SNKIMTDIVA----------------LLTTYVASDFNVQNVNNKQDVNTQ REFGDSAVKIIRSLAKIIS---SKPTHNHTLHDQTLLCLIFICESVDHGQNIAVAAKVYK ELSNC--GLVEVIFKHALNKDL------------WVKDLVKDSDLEKRTDEIQALYLSCL AAVAYIPVIGLPIRQFKN--IVTENIAKL----ITNNSALLSTVS-ILLSHPAMCLNCLK FIYAC-----------A--QLNPDV---CKVLCNESVA-TTLLHILSGSTPTHES----M EIQVIDLVLNIF--TSFTVSASESSKLLLQSSAALLGTVFVQSQQPTHVLSAAGLVYELS N----LGVVFHIGIDEFFSAISSAVSNLTEVDTLPP---SGHGILDGVIGMVQQLVTE-- -GDHQSVHGFITCGAWTALWYRLGHAINVDIKEDNETETLPSTRRITGPARCDDPYDPML MSPDAVLSFLSLATSVFTWEPSKSLPLFSLSNGIVLMSLVALLSDEFISSPNIQLLTNEE DLPILLEELVVENLQCLCFPFAIELSEQKLQQVIACFSELDVIPLILHRCVQNISHRSLE VPMRLISKLCSHHPPSLDRFIHICSHSSTKSSNIVKYLRQTLISPDATSATKSELLGFLN FAVRSKPAKHSSLASEIFFCFNKHHPPAATLCFECTDIEVQTQACLLLGNLL-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >D_rerio_ENSDARP00000081199 ---------------------------------------------M-DQ----------- --------YHILEVIGEGSFGRVYKGRRK-FSGQVVALKFIPKVGRSEKD-LRSLKREID IMRG---LKHPNIVLLLDSFETEREVVVVTE--YAE-GELFQILEDDGSLPEKQ------ ------------------VREIACQLVSALYYLHSHRILHRDMKPQNILLGKGG------ ---------------VVK----L-----CDFGFARAMSVSTLVLTSIKGTPLYMSPELVE EKPYD-HSTDLWSLGCILYELHTGAPPF-YTN-SIFQLVQLIVRDPV---KWPD--NMSQ DCLSFLKGLLMKEPEKRLSW--PDLLHHPFVADGVLMVSDEG---SSNPLTVPPSPDVQA LKHQQVAEKTTVRS---GE---------GKLLGKA--RELREKEKT-------------- --------NRREVA-SGSAARCKTASAGGASNTGHSLG------------STFSVYQN-- ------------------------------------------------------------ --------SSQPATNRHQANDNSVTRARSAPHKGQISRDYAREFPSV---------E--- -------------------VGPRQFLKRPGHEQDMDSDYEWQRLV---------ELSDQ- GPVNASI----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------LQGLKIKLLQAKTQLLVRKG EETSSILLPLK--------VLRNIVQGCRIGD-VETV---GKELELPHLLFSLIEDVLNI PDLMQ------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >T_rubripes_ENSTRUP00000036932 ---------------------------------------------M-VM--ADSVQKPQI RGPVRVGFYDIERTLGKGNFAVVKLARHR-ITKSEVAIKIIDKTQLDAVN-LEKIYREVQ IMKM---LDHPHIIKLYQVMETKNMLYLVTE--YAKNGEIFDYLAKHGRLSELE------ ------------------ARRKFWQILSAVEYCHNRNIVHRDLKAENLLLDGHM------ ---------------NIK----I-----ADFGFGNFFQPGK-PLATWCGSPPYAAPEVFE GQQYEGPQLDIWSMGVVLYVLVCGALPF-DGP-TLPVLRQRVLEGRF---RIPY--FMTE DCEHLIRRMLVLDPSKRLSV--AQIKQHKWMAPYVPVQRPVL---HQQPLSAEGEAGIGE YSEQV-----------------------LRLMHSLGIDQHKTIESL-------------- --------QNKSYN-HFAAIYYLLVERLKAHRCSFPVE------------QRLDARQR-- ------------------------------------------------------------ --------------RPSTIAEQTVVKSTSGLTQVGLHPQGVRLLRS-------------- ------------------SAVPQASS-DVFAFPSAACSLEQNFTVDD-VNTPKVNG---- CLMDPLPPP--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------TVLRKSSTSSPSNMMETSIDEGIETEEPDAE EDPPHLLSAYQ--------TARFGQRRHTLSEVTNQ----PGPSNQGKFFTLGHNPSMGS VDSDMGYD----------------------------MGSMHSDIGLLEDPPSLSELVSSS TSTQTVTPSPFLSARPPNPAMAALTSQHRETHNRSP---------ISFREGRRASDTSLT QGLVAFRQHLQNLARTKGILEL-------------------------------NKVQMLV EHMGSREGTAMSPVGPQHHLHNLLELKGE----ASKQQEGLTLYQGGPHPPLLSRRQSLE TQYLT-------------------HRLQQANVLANSPASCQLFCKEAPRSLEQQLQEHRL NQKRMYLQQSQGMGLQAHFNQMQIAEGSYPAGSSPLEPAT-----HQPP------AQQQT TPQASPP----FTHTHSLSPLMEPGEGLV------------------------------- -------------YDSYMS----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >D_rerio_ENSDARP00000011264 ---------------------------------------------M-GRKEGEYEWKKST DNIQDV--FDFMDVLGSGAFSEVFMVKER-KTGKLFAMKCVKKKNKRD----INLENEIA VLRK---IKHENVVCLEDFYESRTHYYLVMQ--LVSGGELFDRILDRGMYSEMD------ ------------------ASSVIRQVLEAVSYLHNNGIVHRDLKPENLLYYSPD------ ------------ENSKIM----I-----SDFGLSK-MEDNG-VMSTACGTPGYVAPEVLA QKPYS-KAVDCWSIGVITYILLCGYPPF-YEE-TETRLFSKIMKGQY-EFDSPFWDDISE SAKDFIRNMMQKNPKMRFNT--EQALRHPWIIGKTARSQD-----IYHSVSEQMQKNFAK SKWKQAFNATVAIN---HM---------KKLQQAH--SEACVRLKD-------------- ---------------SPRDVPEIKVIASSTP-ESVRKK------------LLSETPEP-- ------------------------------------------------------------ ----------------------NGSMNVPCGSTEAKSQYHPMRVSH-------------- ---------------------SETTHVGTLTIAEK------------------------- GKHVYHSEP--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ADLNGYVKYAKRSSNRP GQNLQ------------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------TGVCSVM ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >D_melanogaster_FBpp0112008 ---------------------------MATTPTAGPAAAPPTSSTP-QNYKVPSTSKISV DKLLRVGYYELEKTIGKGNFAVVKLATNI-VTKTKVAIKIIDKTCLNEEY-LNKTFREIA ILKS---LRHPHITRLYEVMESQSMIYLVTE--YAPNGEIFDHLVANGRMKEPE------ ------------------AARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDM------ ---------------NIK----L-----ADFGFSNHYEEGA-TLKTWCGSPPYAAPEVFQ GLEYDGPKSDIWSLGVVLYALVCGALPF-DGK-TILELKSRVVLGKF---RIPF--FMSQ ECEQLIRNMLVVEPDRRYTI--KQIIKHRWLSEWQSEMQE-------QERFGDMSPGSGT VSKSASTSSLGSAS---DSPPQLDSVVMTHMLQLPGLTADMIAQSV-------------- --------HEQRFD-NIYAIYNLLHDKLQQRRREN---------------QRLQHHAS-- ------------------------------------------------------------ --------------LAYSRSRKTSITTGVVDRSEPVKQESLDRLSP-------------- -------------------LSNANASSSALGFGWSDVAVDLEKYG---------DFELE- CLARSNDPP--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------VNAQHLSAHAGGG------- -------------------VNGANTRRHTVGPGDVAH---EQALANPNVPPIDFKCPPQC SDPTQP------------------------------VPYYPVNLPMLQNQPLHNLTIKDQ HLLKPPVVM------------------------------------GASSFGRRAS----- -----------------------------------------------------DGGANLH IYYPATGTVVGPAQ------GQQMDTAGY----YINPNCGTDPLA-------VQELSPLN EQSVA-----------------------------------------QMQCCQENATGECN EELQSYMQKRGGTQRHTVGCTEDLSVAHGSGAGSQSQAPTTSSNMRQRRTGLLTVTERPP G------------ALERLTKIL-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >D_melanogaster_FBpp0074373 ---------------------------------------------M-NR----------- --------YAVSSMVGQGSFGCVYKATRK-DDSKVVAIKVISKRGRATKE-LKNLRRECD IQAR---LKHPHVIEMIESFESKTDLFVVTE--FAL-MDLHRYLSYNGAMGEEP------ ------------------ARRVTGHLVSALYYLHSNRILHRDLKPQNVLLDKNM------ ---------------HAK----L-----CDFGLARNMTLGTHVLTSIKGTPLYMAPELLA EQPYD-HHADMWSLGCIAYESMAGQPPF-CAS-SILHLVKMIKHEDV---KWPS--TLTS ECRSFLQGLLEKDPGLRISW--TQLLCHPFVEGRIFIAETQAEAAKESPFTN---PEAKV KSSKQSDPEVGDLD---EA---------LAALDFG--ESRQENLTT-------------- --------SRDSIN---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------AIAPSDVEHLETDVEDNMQRVVVPFADLSYRDLSGV- RAMPMVHQP--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------VINSHTCFVSGNSNMILNHMNDNFD--FQASL RGGGVAAKPIV--------APTVRQSRSKDLEK-------RKLSQNLDNFSVRLGHSVDH EAQRK-------------------------------------ATEIATQEKHNQENKPPA EAISYANSQPPQQQPQQLKHSMHSTNEEKLSSDNTPPCLLPGWDSCDESQSPPIENDEWL AFLNR------------------------------------------SVQELLDGELDSL KQHNLVSIIVAPLRNSKAIPRVLKSVAQL----LSLPFVLVDPVL-------IVDLELIR NVYVD-----------V--KLVPNLMYACKLL-------------LSHKQLSDSAASAPL TTGSLSRTLRSI--PELTVEELETACSLYELV---CHLVHLQQQFLTQFCDAVAI----- --LAASDLFLNFLTHDFRQSDSDAASVRLAGCMLA------------------------- -LMGCVLRELPENAEL----------------------------------------VERI VFNPRLNFVSLLQSRHHLLRQRSCQ-LLRLLARFSLRGVQRIWNGELRFALQ-------- ------------------------------------------------------------ ------------------------------------------------Q--LSEHHSYP- -ALRGEAAQTLDEISHFTFFVT-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------