10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0075677 ---------------------------------------------M-NI--------------VGEYEYSSKDMLGHGAFAVVYKGRHR-KKHMPVAIKCITKKGQLKTQ--NLLGKEIK A_gambiae_AGAP011295-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003819-PA ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y60A3A.1.1 ---------------------------------------------M-EQ--------------FDGFEYSKRDLLGHGAFAIVYRGRYVDRTDVPVAIKAIAKKNISKSK--NLLTKEIK D_rerio_ENSDARP00000083843 ---------------------------------------------M-ET--------------VGDFEYSRKDLIGHGAFAVVFKGRHKKKTDWEVAIKSINKKNLSKSQ--ILLGKEIK R_norvegicus_ENSRNOP00000003792 ---------------------------------------------M-EV--------------VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQ--ILLGKEIK P_troglodytes_ENSPTRP00000042372 ---------------------------------------------M-EV--------------VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQ--ILLGKEIK B_taurus_ENSBTAP00000029699 ---------------------------------------------M-EV--------------VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQ--ILLGKEIK M_musculus_ENSMUSP00000004920 ---------------------------------------------M-EV--------------VGDFEYCKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQ--ILLGKEIK H_sapiens_ENSP00000354877 ---------------------------------------------M-EV--------------VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQ--ILLGKEIK O_latipes_ENSORLP00000018791 --------------------------------------ERPTFGPM-EA--------------VGDFEYSRKDLVGHGAFAVVFKGRHRKKTDWEVAIKSINKKNLTKSQ--ILLGKEIK T_nigroviridis_ENSTNIP00000017404 --------------------------------------LDHHPIAM-ET--------------VGDFEYSRKDLVGHGAFAVVFKGRHRKKTDWEVAIKSINKKNLSKSQ--ILLGKEIK T_nigroviridis_ENSTNIP00000008902 -------------------------------------SEVGHGHKM-ET--------------VGKFEFSRKELVGHGAFAVVFKGRHREKHDWEVAVKCINKKNLAKSQ--TLLGKEIR M_domestica_ENSMODP00000005348 -----------------------------------------GTPSM-EV--------------VGDFEYSKKDLVGHGAFAVVFKGRHRKKTDWEVAIKSINKKNLSKSQ--ILLGKEIK T_guttata_ENSTGUP00000007355 ------------------------------------------------------------------FEYSKKDLIGHGAFAVVFKGRHRKKTDWEVAIKSINKKNLSKSQ--ILLGKEIK T_rubripes_ENSTRUP00000015470 --------------------------------------LDHHPVAM-ET--------------VGDFEYSRKDLVGHGAFAVVFKGRHRKKTDWEVAIKSINKKNLSKSQ--ILLGKEIK O_anatinus_ENSOANP00000021856 ------------------------------------------SGPM-ET--------------VGKFEFSRKDLIGHGAFAVVFKGRHQEKHDLEVAVKCINKKNLAKSQ--TLLGKEIK G_gallus_ENSGALP00000007513 -----------------------------------------------------------------TFEYSKKDLIGHGAFAVVFKGRHRKKTDWEVAIKSINKKNLSKSQ--ILLGKEIK G_gallus_ENSGALP00000003776 ---------------------ASSALSAASRPRSCPGRGPPARSAM-ET--------------VGKFEFSRKDLIGHGAFAVVFKGRHKEKPELEVAVKCINKKNLAKSQ--TLLGKEIK G_aculeatus_ENSGACP00000016289 ---------------------------------------------M-ET--------------VGKFEFNRKDLIGHGAFAVVFKGRHKEKRDWVVAVKCINKKNLAKSQ--SLLGKEIK O_latipes_ENSORLP00000013892 --------------------------------------------DM-ET--------------VGKFEFSRKDLIGHGAFAVVFKGRHREKHDWEVAVKCINKKNLAKSQ--TLLGKEIK G_aculeatus_ENSGACP00000017889 ---------------------------------------------M-EP--------------VGDFEYSRKDLVGHGAFAVVFKGRHRKKTDWEVAIKSINKKNLSKSQ--ILLGKEIK M_musculus_ENSMUSP00000108029 --------------------------------------MEPGRGGV-ET--------------VGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQ--TLLGKEIK H_sapiens_ENSP00000324560 --------------------------------------MEPGRGGT-ET--------------VGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQ--TLLGKEIK R_norvegicus_ENSRNOP00000053633 --------------------------------------MEPGRGGV-ET--------------VGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQ--TLLGKEIK O_anatinus_ENSOANP00000020106 ASPFPSAASLPPLHLPSAKLPFPPFLLLLPLSLPLPSALCSSAHLM-EV--------------VGDFEYSKKDLIGHGAFAVVFKGRHRKKTDWEVAIKSINKKNLSKSQ--ILLGKEIK T_rubripes_ENSTRUP00000029855 ---------------------------------------------M-ES--------------VGKFEFSRKDLIGHGAFAVVFKGRHKEKRDWQVAVKCISKKNLAKSQ--ALLGKEIK O_latipes_ENSORLP00000017355 ---------------------------------------------M-ES--------------VGKFEFSRKDLIGHGAFAVVFKGRHKEKHSWEVAVKCINKKNLAKSQ--SLLGKEIK B_taurus_ENSBTAP00000017268 --------------------------RLSPGLPGPVRAMEPGRGGL-EA--------------VGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQ--TLLGKEIK G_aculeatus_ENSGACP00000023344 ---------------------RVIRPARSPARPSSSNSAIRLRRAM-ET--------------VGKFEFSRKDLIGHGAFAVVFKGRHREKHDWEVAVKCINKKNLAKSQ--TLLGKEIK E_caballus_ENSECAP00000007293 -----------------------------------------------------------------------------------------QKTDWEVAIKSINKKNLSKSQ--LLLGKEIK M_domestica_ENSMODP00000031918 ---------------------------------------------M-ET--------------VGKFEFSRKDLIGHGAFAVVFKGRHKEKHDLEVAVKCINKKNLAKSQ--TLLGKEIK M_mulatta_ENSMMUP00000027852 -----------------------------------------------------------------------------------------QKTDWEVAIKSINKKNLSKSQ--ILLGKEIK A_carolinensis_ENSACAP00000000717 ---------------------------------------------M-EA--------------VGDFEYSKKDLIGHGAFAVVFKGRHRKKTDWEVAIKSINKKNLSKSQ--LLLGKEIK P_pygmaeus_ENSPPYP00000009920 ---------------------------------------------M-EV--------------VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQ--ILLGKEIK C_familiaris_ENSCAFP00000026786 ---------------------------------------------M-EV--------------VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQ--ILLGKEIK C_familiaris_ENSCAFP00000009679 -----------------------------------------------------------------------------------------QKHDLEVAVKCINKKNLAKSQ--TLLGKEIK E_caballus_ENSECAP00000014390 -----------------------------------------------------------------------------------------------VAFKCINKKNL-KSQ--TLLGKE-K P_pygmaeus_ENSPPYP00000005848 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000008305 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000020714 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000009595 ------------------------------------------------------------------------------------------------------------------------ S_cerevisiae_YGL180W ---------------------------------------------MGDIKNKDHTTSVNHNLMASAGNYTAEKEIGKGSFATVYRGHLTSDKSQHVAIKEVSRAKLKNKKLLENLEIEIA P_pygmaeus_ENSPPYP00000014729 ---------------------------------------------M-EK-------------------YHVLEMIGEGSFGRVYKGRRK-YSAQVVALKFIPKLGRSEKE-LRNLQREIE M_mulatta_ENSMMUP00000008885 ---------------------------------------------M-EK-------------------YHVLEMIGEGSFGRVYKGRRK-YSAQVVALKFIPKLGRSEKE-LRNLQREIE P_troglodytes_ENSPTRP00000022091 ---------------------------------------------M-EK-------------------YHVLEMIGEGSFGRVYKGRRK-YSAQVVALKFIPKLGRSEKE-LRNLQREIE H_sapiens_ENSP00000295709 ---------------------------------------------M-EK-------------------YHVLEMIGEGSFGRVYKGRRK-YSAQVVALKFIPKLGRSEKE-LRNLQREIE O_cuniculus_ENSOCUP00000001738 ---------------------------------------------M-EK-------------------YHVLEMIGEGSFGRVYKGRKK-YSAQVVALKFIPKLGRSEKE-LKNLQREME B_taurus_ENSBTAP00000038069 ---------------------------------------------M-EK-------------------YHVLEMIGEGSFGRVYKGRRK-YSAQVVALKFIPKLGRSEKE-LRNLQREIE C_familiaris_ENSCAFP00000021994 ---------------------------------------------M-EK-------------------YHVLEMIGEGSFGRVYKGRRK-YSAQVVALKFIPKLGRSEKE-LRNLQREIE G_gallus_ENSGALP00000018526 ---------------------------------------------M-ER-------------------YHVLEVIGEGSFGRVYKGRRR-CSAQVVALKFIPKVGRSEKE-LKNLQREIE R_norvegicus_ENSRNOP00000022839 ---------------------------------------------M-EK-------------------YHVLEMIGEGSFGRVYKGRKK-YSAQVVALKFIPKLGRSEKE-LRNLQREIE E_caballus_ENSECAP00000008449 ---------------------------------------------M-EK-------------------YHVLEMIGEGSFGRVYKGRRK-YSAQVVALKFIPKLGRSEKE-LRNLQREIE M_musculus_ENSMUSP00000084430 ---------------------------------------------M-EK-------------------YHVLEMIGEGSFGRVYKGRKK-YSAQVVALKFIPKLGRSEKE-LRNLQREIE M_domestica_ENSMODP00000019211 -----------------------------LISSSSSRLRDPGALMM-EK-------------------YHVLEMIGEGSFGRVYKGRKK-YSAQVVALKFIPKLGRSDKE-LRNLHREIE A_carolinensis_ENSACAP00000002909 ---------------------------------------------M-EQ-------------------YHVLEMIGEGSFGRVYKGRRK-YTTKIVALKFIPKVGRSQKE-LKNLQREIE G_gorilla_ENSGGOP00000001881 ---------------------------------------------M-EK-------------------YHVLEMIGEGSFGRVYKGRRK-YSAQXXXXXXXXXXXXXXXX-LRNLQREIE G_aculeatus_ENSGACP00000012128 ---------------------------------------------M-VM--AESAQKPLIRGPVRVGFYDIERTLGKGNFAVVKLARHR-ITKTEVAIKIIDKTQLDAVN-LEKIYREVQ M_domestica_ENSMODP00000018106 ---------------------------------------------M-VM--ADGP-RHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHR-ITKTEVAIKIIDKSQLDAVN-LEKIYREVQ C_intestinalis_ENSCINP00000014205 -------------------------------------------LNM-DN-------------------YQVLELIGEGSFGKVYKGRKK-YTGSTVALKFIPKAGKSDKD-LRNLRKEIE D_rerio_ENSDARP00000081199 ---------------------------------------------M-DQ-------------------YHILEVIGEGSFGRVYKGRRK-FSGQVVALKFIPKVGRSEKD-LRSLKREID T_rubripes_ENSTRUP00000036932 ---------------------------------------------M-VM--ADSVQKPQIRGPVRVGFYDIERTLGKGNFAVVKLARHR-ITKSEVAIKIIDKTQLDAVN-LEKIYREVQ D_rerio_ENSDARP00000011264 ---------------------------------------------M-GRKEGEYEWKKSTDNIQDV--FDFMDVLGSGAFSEVFMVKER-KTGKLFAMKCVKKKNKRD----INLENEIA D_melanogaster_FBpp0112008 ---------------------------MATTPTAGPAAAPPTSSTP-QNYKVPSTSKISVDKLLRVGYYELEKTIGKGNFAVVKLATNI-VTKTKVAIKIIDKTCLNEEY-LNKTFREIA D_melanogaster_FBpp0074373 ---------------------------------------------M-NR-------------------YAVSSMVGQGSFGCVYKATRK-DDSKVVAIKVISKRGRATKE-LKNLRRECD 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0075677 ILKELTELHHENVVALLDCKESQDCVSLVME--YCNGGDLADYLSVKGTLSEDT------------------------VRLFLVQLAGAMKALYTKGIVHRDLKPQNILLSHNYGKTLPA A_gambiae_AGAP011295-PA ---------------------------------YCNGGDLADYLAVKGTLSEDT------------------------IRLFLGQLANAMKALYQADVVHRDLKPQNILLSHNCGKGLPI A_aegypti_AAEL003819-PA ------------------------------------------------------------------------------------------------------MRPA-------------- C_elegans_Y60A3A.1.1 ILKELSSLKHENLVGLLKCTETPTHVYLVME--FCNGGDLADYLQQKTTLNEDT------------------------IQHFVVQIAHALEAINKKGIVHRDLKPQNILLCNNSRTQNPH D_rerio_ENSDARP00000083843 ILKE---LQHENIVALYDVQETPSSVFLVME--YCNGGDLADYLQAKGTLREDT------------------------LRVFLQQIAAAMRILNSKGIIHRDLKPQNILLSYTGRKK-SS R_norvegicus_ENSRNOP00000003792 ILKE---LQHENIVALYDVQELPNSVFLVME--YCNGGDLADYLQAKGTLSEDT------------------------IRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYASRRK-SN P_troglodytes_ENSPTRP00000042372 ILKE---LQHENIVALYDVQELPNSVFLVME--YCNGGDLADYLQAKGTLSEDT------------------------IRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRK-SS B_taurus_ENSBTAP00000029699 ILKE---LQHENIVALYDVQELPNSVFLVME--YCNGGDLADYLQAKGTLSEDT------------------------IRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYASRKK-SS M_musculus_ENSMUSP00000004920 ILKE---LQHENIVALYDVQELPNSVFLVME--YCNGGDLADYLQAKGTLSEDT------------------------IRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRK-SN H_sapiens_ENSP00000354877 ILKE---LQHENIVALYDVQELPNSVFLVME--YCNGGDLADYLQAKGTLSEDT------------------------IRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRK-SS O_latipes_ENSORLP00000018791 ILKE---LQHENIVGLYDVQETPNSVFLVME--YCNGGDLADYLQAKGTLREDT------------------------MRVFLQQIAAAMRVLNSKGIIHRDLKPQNILLSYSARKR-SN T_nigroviridis_ENSTNIP00000017404 ILKE---LQHENIVGLYDVQETPNSVFLVME--YCNGGDLADYLQAKGTLREDT------------------------LRVFLQQIAAAMRILNSKGIIHRDLKPQNILLSYAGRKK-SN T_nigroviridis_ENSTNIP00000008902 ILKE---LKHDNIVALLDFQETVSSVFLVME--YCNGGDLADYLHSKGTLSEDT------------------------IRVFLQQIAGAMRVLQSKGIIHRDLKPQNILLSHLPGRK-SH M_domestica_ENSMODP00000005348 ILKE---LQHENIVALYDVQELPNSVFLVME--YCNGGDLADYLQAKGTLSEDT------------------------IRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYASRRK-SS T_guttata_ENSTGUP00000007355 ILKE---LQHENIVALYDVQEMPNSVFLVME--YCNGGDLADYLQAKGTLSEDT------------------------IRVFLQQIAAAMRILHSKGIIHRDLKPQNILLSYASRRK-SS T_rubripes_ENSTRUP00000015470 ILKE---LQHENIVGLYDVQETPNSVFLVME--YCNGGDLADYLQAKGTLREDT------------------------LRVFLQQIAAAMRILNSKGIIHRDLKPQNILLSYAGRKK-SN O_anatinus_ENSOANP00000021856 ILKE---LKHENIVALYDFQEMANSVYLVME--YCNGGDLADYLHSMRTLSEDT------------------------IRIFLQQIAGAMKMLHSKGIIHRDLKPQNILLSYPGARK-SN G_gallus_ENSGALP00000007513 ILKE---LQHENIVALYDVQEMPSSVFLVME--YCNGGDLADYLQAKGTLSEDT------------------------IRVFLQQIAAAMRILHSKGIIHRDLKPQNILLSYASRRK-SS G_gallus_ENSGALP00000003776 ILKE---LKHENIVALYDFQEVANSVYLVME--YCNGGDLADYLHTMRTLSEDT------------------------IRLFLQQIAGAMKMLHSKGIIHRDLKPQNILLSYSGGRK-SN G_aculeatus_ENSGACP00000016289 ILKE---LKHENIVRLLDYQEMGGCVYLVME--YCNGGDLAEYLHSKGTLREDT------------------------IRVFLQQIGQAMKVLQSKDILHRDLKPQNILLCHPEGRR-SS O_latipes_ENSORLP00000013892 ILKE---LKHENIVALLDFQETVSSVYLVME--YCNGGDLADYLHSKGTLSEDT------------------------IRVFLQQIVGAIKVLQSKGIIHRDLKPQNILLSYPAGRK-SH G_aculeatus_ENSGACP00000017889 ILKE---LQHENIVALYDVQETPNSVFLVME--YCNGGDLADYLQAKGTLREDT------------------------LRVFLQQIAAAMRILNSKGIIHRDLKPQNILLSYAGRKR-SN M_musculus_ENSMUSP00000108029 ILKE---LKHENIVALYDFQEMANSVYLVME--YCNGGDLADYLHTMRTLSEDT------------------------VRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRR-AN H_sapiens_ENSP00000324560 ILKE---LKHENIVALYDFQEMANSVYLVME--YCNGGDLADYLHAMRTLSEDT------------------------IRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRR-AN R_norvegicus_ENSRNOP00000053633 ILKE---LKHENIVALYDFQEMANSVYLVME--YCNGGDLADYLHTMRTLSEDT------------------------VRLFLQQIAGAMQLLHSKGIIHRDLKPQNILLSNPGGRR-AN O_anatinus_ENSOANP00000020106 ILKE---LQHENIVALYDVQELPNSVFLVME--YCNGGDLADYLQGTFCLFSKE-----------------------------HQIAAAMRILHGKGIIHRDLKPQNILLSYASRRK-ST T_rubripes_ENSTRUP00000029855 ILKE---LKHENIVRLLDYQEIGGCVYLVME--YCNGGDLAEYLHTKGTLSEDT------------------------IRIFLQQIAQAMEVLRIKGILHRDLKPQNILLCHPVGRR-SS O_latipes_ENSORLP00000017355 ILKE---LKHGNIVRLLDYQEIGGCVYLVME--YCNGGDLAEYLHSKGTLSEDT------------------------IRIFLQQIAQAMKVLQSKGILHRDLKPQNILLCHPEGRK-SS B_taurus_ENSBTAP00000017268 ILKE---LKHENIVALYDFQEMANSVYLVME--YCNGGDLADYLHTMRTLSEDT------------------------IRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRR-AN G_aculeatus_ENSGACP00000023344 ILKE---LKHENIVALLDFQETASSVYLVMETQYCNGGDLADYLHTKGTLSEDT------------------------IRVFLQQIAGAMRVLQGKGIIHRDLKPQNILLSYPPGRR-SH E_caballus_ENSECAP00000007293 ILKE---LQHENIVALYDVQELPNSVFLVME--YCNGGDLADYLQAKGTLSEDT------------------------IRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRK-SS M_domestica_ENSMODP00000031918 ILKE---LKHENIVALYDFQEVASSVYLVME--YCNGGDLADYLHSMRTLSEDT------------------------IRLFLQQIAGAMKMLHSKGIIHRDLKPQNILLSYSGGRK-SN M_mulatta_ENSMMUP00000027852 ILKE---LQHENIVALYDVQELPNSVFLVME--YCNGGDLADYLQAKGTLSEDT------------------------IRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRK-SS A_carolinensis_ENSACAP00000000717 ILKE---LQHENIVALYDVQELPNSVFLVME--YCNGGDLADYLQAKGTLSEDT------------------------IRVFLQQIAAAMRILHGKGIIHRDLKPQNILLSYANRRK-SS P_pygmaeus_ENSPPYP00000009920 ILKE---LQHENIVALYDVQ--------------------------KGTLSEDT------------------------IRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRK-SS C_familiaris_ENSCAFP00000026786 ILKE---LQHENIVALYDVQELPNSVFLVME--YCNGGDLADYLQAKGTLSEDT------------------------IRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRK-SN C_familiaris_ENSCAFP00000009679 ILKE---LKHENIVALYDFQEMANSVYLVME--YCNGGDLADYLHTMRTLSEDT------------------------IRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRR-AN E_caballus_ENSECAP00000014390 ILKE---LKHENIVALYDFQEMANSVYLVME--YCNGGDLADYLHTMRTLSEDT------------------------IRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPSGRR-AN P_pygmaeus_ENSPPYP00000005848 ---E---LKHENIVALYDFQEMANSVYLVME--YCNGGDLADYLHTMRTLSEDT------------------------IRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRR-AN T_guttata_ENSTGUP00000008305 -------------------QELANSVYLVME--YCNGGDLADYLHTMRTLSEDT------------------------IRLFLQQIAGAMKMLHSKGIIHRDLKPQNILLSYAGGRK-SN M_mulatta_ENSMMUP00000020714 -------------------QEMANSVYLVME--YCNGGDLADYLHTMRTLSEDT------------------------IRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRR-AN P_troglodytes_ENSPTRP00000009595 --------------------EMANSVYLVME--YSNGGDLPDYLHAMRTLSEDT------------------------IRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRR-AN S_cerevisiae_YGL180W ILKK---IKHPHIVGLIDCERTSTDFYLIME--YCALGDLTFLLKRRKELMENHPLLRTVFEKYPPPSENHNGLHRAFVLSYLQQLASALKFLRSKNLVHRDIKPQNLLLSTPLIGYHDS P_pygmaeus_ENSPPYP00000014729 IMRG---LRHPNIVHMLDSFETDKEVVVVTD--YAE-GELFQILEDDGKLPEDQ------------------------VQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGG------ M_mulatta_ENSMMUP00000008885 IMRG---LRHPNIVHMLDSFETDKEVVVVTD--YAE-GELFQILEDDGKLPEDQ------------------------VQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGG------ P_troglodytes_ENSPTRP00000022091 IMRG---LRHPNIVHMLDSFETDKEVVVVTD--YAE-GELFQILEDDGKLPEDQ------------------------VQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGG------ H_sapiens_ENSP00000295709 IMRG---LRHPNIVHMLDSFETDKEVVVVTD--YAE-GELFQILEDDGKLPEDQ------------------------VQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGG------ O_cuniculus_ENSOCUP00000001738 IMRG---LRHPNIVHMLDSFETDKEVVVVTD--YAE-GELFQILEDDGKLPEDQ------------------------VQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGG------ B_taurus_ENSBTAP00000038069 IMRG---LRHPNIVHMLDSFETDKEVVVVTD--YAE-GELFQILEDDGKLPEDQ------------------------VQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGG------ C_familiaris_ENSCAFP00000021994 IMRG---LRHPNIVHMLDSFETDKEVVVVTD--YAE-GELFQILEDDGKLPEDQ------------------------VQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGG------ G_gallus_ENSGALP00000018526 IMRG---LHHPNIIQMLDSFETDKEVVMVTD--YAE-GELFQILEDDGSLPEDQ------------------------VQTIAAQLVSALYYLHSHRILHRDMKPQNILLGKDG------ R_norvegicus_ENSRNOP00000022839 IMRG---LWHPNIVHMLDSFETDKEVVVVTD--YAE-GELFQILEDDGKLPEEQ------------------------VQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGG------ E_caballus_ENSECAP00000008449 IMRG---LRHPNIVHMLDSFETDKEVVVVTD--YAE-GELFQILEDDGKLPEDQ------------------------VQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGG------ M_musculus_ENSMUSP00000084430 IMRG---LWHPNIVHMLDSFETDKEVVVVTD--YAE-GELFQILEDDGKLPEDQ------------------------VQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGG------ M_domestica_ENSMODP00000019211 IMRG---LRHPNIIQMLDSFETDKEVVVVTD--YAE-GELFQILEDDGKLPEDQ------------------------VQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGG------ A_carolinensis_ENSACAP00000002909 IMRG---LHHPNIVQMLDSFETDKEVVVVTD--YAE-GELFQILEDDGNLPEEQ------------------------VQIIASQLVSALYYLHSHRILHRDMKPQNILLGKGG------ G_gorilla_ENSGGOP00000001881 IMRG---LRHPNIVHMLDSFETDKEVVVVTD--YAE-GELFQILEDDGKLPEDQ------------------------VQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGG------ G_aculeatus_ENSGACP00000012128 IMKM---LEHPHIIKLYQVMETKNMLYLVTE--YAKNGEIFDYLAKHGRLSELE------------------------ARRKFWQILSAVEYCHNRNIVHRDLKAENLLLDGHM------ M_domestica_ENSMODP00000018106 IMKM---LDHPHIIKLYQVMETKSMLYLVTE--YAKNGEIFDYLANHGRLSESE------------------------ARRKFWQILSAVDYCHSRKIVHRDLKAENLLLDNNM------ C_intestinalis_ENSCINP00000014205 IMSD---LQHPNIIQLLDNFETEQEVVVVTE--YAE-GELFQILEDDGKLSEDQ------------------------VQEIASQLVSALYYLHSHRILHRDMKPQNILIGKGG------ D_rerio_ENSDARP00000081199 IMRG---LKHPNIVLLLDSFETEREVVVVTE--YAE-GELFQILEDDGSLPEKQ------------------------VREIACQLVSALYYLHSHRILHRDMKPQNILLGKGG------ T_rubripes_ENSTRUP00000036932 IMKM---LDHPHIIKLYQVMETKNMLYLVTE--YAKNGEIFDYLAKHGRLSELE------------------------ARRKFWQILSAVEYCHNRNIVHRDLKAENLLLDGHM------ D_rerio_ENSDARP00000011264 VLRK---IKHENVVCLEDFYESRTHYYLVMQ--LVSGGELFDRILDRGMYSEMD------------------------ASSVIRQVLEAVSYLHNNGIVHRDLKPENLLYYSPD------ D_melanogaster_FBpp0112008 ILKS---LRHPHITRLYEVMESQSMIYLVTE--YAPNGEIFDHLVANGRMKEPE------------------------AARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDM------ D_melanogaster_FBpp0074373 IQAR---LKHPHVIEMIESFESKTDLFVVTE--FAL-MDLHRYLSYNGAMGEEP------------------------ARRVTGHLVSALYYLHSNRILHRDLKPQNVLLDKNM------ 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0075677 -----------PSKITLK----I-----ADFGFARFLNEGA-MAATLCGSPMYMAPEVIMSLQYD-SKADLWSLGTIVYQCLTGKAPF-YAQ-TPNELKSYYEQNANLAPKIPS--GVSP A_gambiae_AGAP011295-PA -----------PSKITLK----I-----ADFGFARFLQDGN-MAATLCGSPMYMAPEVIMSLQYD-AKADLWSLGTIVFQCLTGKAPF-QAH-TPQELKMFYERNANLAPKIPS--GTSK A_aegypti_AAEL003819-PA -----------PSSVCTK------------------------------------AARTIM--------------------------PL-------------------------------- C_elegans_Y60A3A.1.1 -----------FTDIVIK----L-----ADFGFARFLNDGV-MAATLCGSPMYMAPEVIMSMQYD-AKADLWSIGTILFQCLTGKAPF-VAQ-TPPQLKAYYEKTRELRPNIPE--WCSP D_rerio_ENSDARP00000083843 -----------INGIRIK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIMSQNYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNKSLVPNIPR--ETSP R_norvegicus_ENSRNOP00000003792 -----------VSGIRIK----I-----ADFGFARYLHSNT-MAATLCGSPMYMAPEVIMSQHYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNRSLMPSIPR--ETSP P_troglodytes_ENSPTRP00000042372 -----------VSGIRIK----I-----ADFGFARYLHSNM-MAATLCGSPMYMAPEVIMSQHYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNRSLMPSIPR--ETSP B_taurus_ENSBTAP00000029699 -----------VSGIRIK----I-----ADFGFARYLHSNM-MAATLCGSPMYMAPEVIMSQHYD-AKADLWSIGTVIYQCLVGKPPFQQAN-SPQDLRMFYEKNRNLMPSIPR--ETSP M_musculus_ENSMUSP00000004920 -----------VSGIRIK----I-----ADFGFARYLHSNT-MAATLCGSPMYMAPEVIMSQHYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNRSLMPSIPR--ETSP H_sapiens_ENSP00000354877 -----------VSGIRIK----I-----ADFGFARYLHSNM-MAATLCGSPMYMAPEVIMSQHYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNRSLMPSIPR--ETSP O_latipes_ENSORLP00000018791 -----------VSSIRVK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIMSQNYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRLFYEKNKNLQPIIPR--ETSP T_nigroviridis_ENSTNIP00000017404 -----------ISGIRIK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIMSQNYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNKNLQPIIPS--ETSP T_nigroviridis_ENSTNIP00000008902 -----------CNNTCIK----I-----ADFGFARYLQNNM-MAATLCGSPMYMAPEVIMSQNYD-AKADLWSIGTIVFQCLTGKAPF-QAS-SPQDLRLFYEKNKSLSPDIPR--ETSH M_domestica_ENSMODP00000005348 -----------VSGIRIK----I-----ADFGFARYLHSNM-MAATLCGSPMYMAPEVIMSQHYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNRSLIPSIPR--ETSP T_guttata_ENSTGUP00000007355 -----------VSGIRIK----I-----ADFGFARYLHSNM-MAATLCGSPMYMAPEVIMSQHYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNRNLIPSIPR--ETSA T_rubripes_ENSTRUP00000015470 -----------ISGIRIK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIMSQNYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNKNLQPIIPS--ETSP O_anatinus_ENSOANP00000021856 -----------PNNIRVK----I-----ADFGFARYLQNNM-MAATLCGSPMYMAPEVIMSQHYD-AKADLWSIGTIIYQCLTGKAPF-QAS-SPQDLRLFYEKNKTLMPNIPR--ETSG G_gallus_ENSGALP00000007513 -----------VSGIRIK----I-----ADFGFARYLHSNM-MAATLCGSPMYMAPEVIMSQHYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNRNLIPSIPR--ETST G_gallus_ENSGALP00000003776 -----------PNNIRIK----I-----ADFGFARYLQNNM-MAATLCGSPMYMAPEVIMSQHYD-AKADLWSIGTIIYQCLTGKAPF-QAS-SPQDLRLFYEKNKILMPNIPR--ETSS G_aculeatus_ENSGACP00000016289 -----------PINTSIK----I-----ADFGFARHLQTNT-MAATLCGSPMYMAPEVIMSQNYD-AKADLWSIGTIVYQCLTGKAPF-HAS-TPQELRLFYESNRTLLPNIPK--ETSP O_latipes_ENSORLP00000013892 -----------CNNICIK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIMSQNYD-ARADLWSVGTIVFQCLTGKAPF-QAS-SPQDLRLFYEKNKNLSPNIPR--ETSQ G_aculeatus_ENSGACP00000017889 -----------ISGIRIK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIMSQNYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNKTLQPIIPR--ETSQ M_musculus_ENSMUSP00000108029 -----------PSNIRVK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIMSQHYD-GKADLWSIGTIVYQCLTGKAPF-QAS-SPQDLRLFYEKNKTLVPAIPR--ETSA H_sapiens_ENSP00000324560 -----------PNSIRVK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIMSQHYD-GKADLWSIGTIVYQCLTGKAPF-QAS-SPQDLRLFYEKNKTLVPTIPR--ETSA R_norvegicus_ENSRNOP00000053633 -----------PSNIRVK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIMSQHYD-GKADLWSIGTIVYQCLTGKAPF-QAS-SPQDLRLFYEKNKTLVPAIPR--ETSA O_anatinus_ENSOANP00000020106 -----------ISGIRVK----I-----ADFGFARYLHSNM-MAATLCGSPMYMAPEVIMSQHYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNRSLIPSIPR--ETSP T_rubripes_ENSTRUP00000029855 -----------PINTCIK----I-----ADFGFARHLQTNT-MAATMCGSPMYMAPEVIMSQHYD-AKADLWSIGTIVYQCLTGKAPF-RAS-TPQELRLFYESNRTLLPSVPK--ETSH O_latipes_ENSORLP00000017355 -----------SINASIK----I-----ADFGFARHLQTNM-MAATLCGSPMYMAPEVIMSQNYD-AKADLWSIGTIMYQCLTGKAPF-HAS-SPQELRLFYESNTTLLPSIPK--ETSP B_taurus_ENSBTAP00000017268 -----------PNNIRVK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIMSQHYD-GKADLWSIGTIVYQCLTGKAPF-QAS-SPQDLRLFYEKNKTLVPTIPR--ETSA G_aculeatus_ENSGACP00000023344 -----------SNNTCIK----IDFVPTADFGFARYLQSNM-MAATLCGSPMYMAPEVIMSQSYD-AKADLWSIGTIVFQCLIGKAPF-QAS-SPQDLRLFYEKNKTLSPNIPR--ETSS E_caballus_ENSECAP00000007293 -----------VSGIRIK----I-----ADFGFARYLHSNM-MAATLCGSPMYMAPEVIMSQHYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNRSLMPSIPR--ETSP M_domestica_ENSMODP00000031918 -----------PNNIRVK----I-----ADFGFARYLQNNM-MAATLCGSPMYMAPEVIMSQHYD-AKADLWSIGTIIYQCLTGKAPF-QAS-SPQDLRLFYEKNKTLLPSIPR--ETSS M_mulatta_ENSMMUP00000027852 -----------VSGIRIK----I-----ADFGFARYLHSNM-MAATLCGSPMYMAPEVIMSQHYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNRSLMPSIPR--ETSP A_carolinensis_ENSACAP00000000717 -----------LSGIRIK----IG---KSDFGFARYLQSNM-MAATLCGSPMYMAPEVIMSQHYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNRNLIPSVPR--ETSP P_pygmaeus_ENSPPYP00000009920 -----------VSGIRIK----I-----ADFGFARYLHSNM-MAATLCGSPMYMAPEVIMSQHYD-AKADLWSIGTVIYQCLVGKPPF-QAN-SPQDLRMFYEKNRSLMPSIPR--ETSP C_familiaris_ENSCAFP00000026786 -----------VSGIRIKIVCEI-----ADFGFARYLHSNM-MAATLCGSPMYMAPEVIMSQHYD-AKADLWSIGTVVYQCLVGKPPF-QSSCCPVTKRFFEPENWSKSPSIPR--ETSP C_familiaris_ENSCAFP00000009679 -----------PNNIRVK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIMSQHYD-GKADLWSIGTIVYQCLTGKAPF-QAS-SPQDLRLFYERNKTLVPTIPR--ETSA E_caballus_ENSECAP00000014390 -----------PNNIRVK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIMSQHYD-GKADLWSIGTIVYQCLTGKAPF-QAS-SPQDLRLFYEKNKTLVPIIPR--ETSA P_pygmaeus_ENSPPYP00000005848 -----------PNSIRVK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIMSQHYD-GKADLWSIGTIVYQCLTGKAPF-QAS-SPQDLRLFYEKNKTLVPTIPR--ETSA T_guttata_ENSTGUP00000008305 -----------PNNIRIK----I-----ADFGFARYLQNNM-MAATLCGSPMYMAPEVIMSQHYD-AKADLWSIGTIIYQCLTGKAPF-QAS-SPQDLRLFYEKNKMLMPNIPR--ETSS M_mulatta_ENSMMUP00000020714 -----------PNSIRVK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIMSQHYD-GKADLWSIGTIVYQCLTGKAPF-QAS-SPQDLRLFYEKNKTLVPIIPR--ETSA P_troglodytes_ENSPTRP00000009595 -----------PNSIRVK----I-----ADFGFARYLQSNM-MAATLCGSPMYMAPEVIMSQHYD-GKADLWSIGTIVYQCLTGKAPF-QAS-SPQDLRLFYEKNKTLVPTIPR--ETSA S_cerevisiae_YGL180W KSFHELGFVGIYNLPILK----I-----ADFGFARFLPNTS-LAETLCGSPLYMAPEILNYQKYN-AKADLWSVGTVVFEMCCGTPPF-RAS-NHLELFKKIKRAND-VITFPSYCNIEP P_pygmaeus_ENSPPYP00000014729 ---------------GIK----L-----CDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYD-HTADLWSVGCILYELAVGTPPF-YAT-SIFQLVSLILKDPV---RWPS--TISP M_mulatta_ENSMMUP00000008885 ---------------GIK----L-----CDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYD-HTADLWSVGCILYELAVGTPPF-YAT-SIFQLVSLILKDPV---RWPS--TISP P_troglodytes_ENSPTRP00000022091 ---------------GIK----L-----CDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYD-HTADLWSVGCILYELAVGTPPF-YAT-SIFQLVSLILKDPV---RWPS--TISP H_sapiens_ENSP00000295709 ---------------GIK----L-----CDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYD-HTADLWSVGCILYELAVGTPPF-YAT-SIFQLVSLILKDPV---RWPS--TISP O_cuniculus_ENSOCUP00000001738 ---------------GIK----L-----CDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYD-HTADLWSVGCILYELAVGTPPF-YTT-SIFQLVSLILKDPV---RWPS--TISP B_taurus_ENSBTAP00000038069 ---------------GIK----L-----CDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYD-HTADLWSVGCILYELAVGTPPF-YTT-SIFQLVSLILKDPV---RWPP--TISP C_familiaris_ENSCAFP00000021994 ---------------GIK----L-----CDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYD-HTADLWSVGCILYELAVGTPPF-YTT-SIFQLVSLILKDPV---RWPT--TISP G_gallus_ENSGALP00000018526 ---------------VIK----L-----CDFGFARAMSIHTMVLTSIKGTPLYMSPELVEERPYD-HTADLWSVGCILYELFMGTPPF-YTS-SIFQLVSLIVKDPV---KWPK--AISP R_norvegicus_ENSRNOP00000022839 ---------------GIK----L-----CDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYD-HTADLWSVGCILYELAVGTPPF-YTT-SIFQLVSLILKDPV---RWPS--TITS E_caballus_ENSECAP00000008449 ---------------GIK----L-----CDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYD-HTADLWSVGCILYELAVGTPPF-YTT-SIFQLVSLILKDPV---RWPP--TISP M_musculus_ENSMUSP00000084430 ---------------GIK----L-----CDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYD-HTADLWSVGCILYELAVGTPPF-YTT-SIFQLVSLILKDPV---RWPS--TISS M_domestica_ENSMODP00000019211 ---------------GIK----L-----CDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYD-HTADLWSVGCILYELAVGTPPF-YTT-SIFQLVSLILKDPV---RWPP--TISQ A_carolinensis_ENSACAP00000002909 ---------------VIK----L-----CDFGFARAMSIHTMVLTSIKGTPLYMSPELVEEKPYD-HTADLWSVGCILYELYVGTPPF-YTN-SIFQLVSLIIKDPV---KWPK--NMSL G_gorilla_ENSGGOP00000001881 ---------------GIK----L-----CDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYD-HTADLWSVGCILYELAVGTPPF-YAT-SIFQLVSLILKDPV---RWPS--TISP G_aculeatus_ENSGACP00000012128 ---------------NIK----I-----ADFGFGNFFQPGE-PLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPF-DGP-TLPVLRQRVLEGRF---RIPY--FMTE M_domestica_ENSMODP00000018106 ---------------NIK----I-----ADFGFGNFFKSGE-PLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPF-DGP-TLPILRQRVLEGRF---RIPY--FMSE C_intestinalis_ENSCINP00000014205 ---------------VVK----L-----CDFGFARAMSMNTLVLTSIKGTPLYMSPELVEEKPYD-HNADLWSLGCILYELFVGKPPF-YTN-SIFQLVSLIIKDDI---KWLK--SMSD D_rerio_ENSDARP00000081199 ---------------VVK----L-----CDFGFARAMSVSTLVLTSIKGTPLYMSPELVEEKPYD-HSTDLWSLGCILYELHTGAPPF-YTN-SIFQLVQLIVRDPV---KWPD--NMSQ T_rubripes_ENSTRUP00000036932 ---------------NIK----I-----ADFGFGNFFQPGK-PLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPF-DGP-TLPVLRQRVLEGRF---RIPY--FMTE D_rerio_ENSDARP00000011264 ------------ENSKIM----I-----SDFGLSK-MEDNG-VMSTACGTPGYVAPEVLAQKPYS-KAVDCWSIGVITYILLCGYPPF-YEE-TETRLFSKIMKGQY-EFDSPFWDDISE D_melanogaster_FBpp0112008 ---------------NIK----L-----ADFGFSNHYEEGA-TLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGALPF-DGK-TILELKSRVVLGKF---RIPF--FMSQ D_melanogaster_FBpp0074373 ---------------HAK----L-----CDFGLARNMTLGTHVLTSIKGTPLYMAPELLAEQPYD-HHADMWSLGCIAYESMAGQPPF-CAS-SILHLVKMIKHEDV---KWPS--TLTS 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0075677 DLRDLLLCLLRRNSKDRISY--ESFFVHRFLQGKKAAVSP-----VDMPPLGGTPPAKAKSPLQQQLEQELKLV---KLAEQQQKEREEQEAQEDENTVSVVANPAICATITNVG--VLC A_gambiae_AGAP011295-PA ELTDLLMGLLRRNAKERMNF--DTFFNHPFLQRAETPQGK-------------NGFNIAEVTVAIPLRESVSIL---LLFLLKCVLQRRRCAVLV--AVVVFNTFFLCVSFFPVPIAELD A_aegypti_AAEL003819-PA ---------------------------------------------------------------------------------------------------------------------EID C_elegans_Y60A3A.1.1 NLRDLLLRLLKRNAKDRISF--EDFFNHPFLTS------------PLLPSPSKRILESARSPLLA-NRRIITPQ---SS---------LPVPKRA--GSTKLDSPTPVRRIGESP--RVQ D_rerio_ENSDARP00000083843 QLEDLLLGLLQRNQKDRIDF--DTFFSHPFLEPISTIKKS-----CPVPVPSCSGLVSDSTCGSSPSCRYVSPP---SL---------PDM-QTL--PEDVLSSPP----LGPPN--YLQ R_norvegicus_ENSRNOP00000003792 YLANLLLGLLQRNQKDRMDF--EAFFSHPFLEQVP-VRKS-----CPVPVPVYSGPGPGSSCSSSPPCRFASPP---SL---------PDM-QHI--QEENLSSPP----LGPPN--YLQ P_troglodytes_ENSPTRP00000042372 YLANLLLGLLQRNQKDRMDF--EAFFSHPFLEQGP-VKKS-----CPVPVPMYSGSVSGSSCGSSPSCRFASPP---SL---------PDM-QNI--QEENLSSSP----LGPPN--YLQ B_taurus_ENSBTAP00000029699 YLANLLLGLLQRNQKDRMDF--EAFFSHPFLEQVP-AKKS-----CPVPVPMYAGSASGGSYGSSPSCRFVSPP---SL---------PDM-QHI--QEENLSSPP----LGPPN--YLQ M_musculus_ENSMUSP00000004920 YLANLLLGLLQRNQKDRMDF--EAFFSHPFLEQVP-VKKS-----CPVPVPVYSGPVPGSSCSSSPSCRFASPP---SL---------PDM-QHI--QEENLSSPP----LGPPN--YLQ H_sapiens_ENSP00000354877 YLANLLLGLLQRNQKDRMDF--EAFFSHPFLEQGP-VKKS-----CPVPVPMYSGSVSGSSCGSSPSCRFASPP---SL---------PDM-QHI--QEENLSSPP----LGPPN--YLQ O_latipes_ENSORLP00000018791 QLTDLLLGLLQRNQKDRMDF--DTFFSHPFLESSSTIKKS-----CPVPVPSTSAAVTDSSCGSSPCIRYSSPPDTQSL---------PDM-QTL--AEDGLSSPP----LGPPN--FLQ T_nigroviridis_ENSTNIP00000017404 QLRDLLLGLLQRNQKDRMDF--DTFFSHPFLEPSSTIKKS-----CPVPVPSTSNTATDSSCGSSPCIRYSSPP---SL---------PDM-QTL--AEDGLSSPP----LGPPN--FLQ T_nigroviridis_ENSTNIP00000008902 HLRHLLLGLLQRNHTERMDF--DQFFSHPFLETSSSIKRV----VPAVSTMCPPGSPSASSCSSSSTSHLASPPN--SL---------AEG-QQL----RVRTSAN----QEMDG--LLL M_domestica_ENSMODP00000005348 YLANLLLGLLQRNQKDRMDF--EAFFSHPFLEQVP-VKKS-----CPVPVPIYAGSVSGSSCGSSPSCRFASPP---SL---------PDM-QHI--QEDNLSSPP----LGPPN--YLQ T_guttata_ENSTGUP00000007355 YLADLLLGLLQRNQKDRMDF--EAFFNHPFLDHVSTVKKS-----CPVPVPTYPGSVSGSSCGSSP-CRFASPP---SL---------PDM-QHI--QEENLSSPP----LGPPN--YLQ T_rubripes_ENSTRUP00000015470 QLRDLLLGLLQRNQKDRMDF--DTFFSHPFLEPSSAIKKS-----CPVPVPSTSNTATDSSCGSSPCIRYNSPP---SL---------PDM-QTL--AEDGLSSPP----LGPPN--FLQ O_anatinus_ENSOANP00000021856 HLRQLLLGLLQRNHKDRMDF--DEFFHHPFLDASSSIKKS-----PPVPMPSYPSSGSGSSSSSSSTSHLASPP---SL---------GEM-QQ---LQKTLTSPN----QDTTG--FLH G_gallus_ENSGALP00000007513 YLADLLLGLLQRNQKDRMDF--EAFFNHPFLDQISTVKKS-----CPVPVPTYAGSVSGSSCGSSPSCRFASPP---SL---------PDM-QHI--QEENLSSPP----LGPPN--YLQ G_gallus_ENSGALP00000003776 HLRQLLLGLLQRNHKDRMDF--DEFFHHPFLDASASMKKS-----ASVPMPSYPSSGSGSSSSSSSTSHLASPP---SL---------GEMQQQL--QEKALASPT----QDSPG--FLH G_aculeatus_ENSGACP00000016289 NLRHLVLGLLQRNHKERFGF--DEFFHHPFLEASSSSKKC-----SPPAVISLPGSSSVSSSSGSSTSYLTSPQH--SD---------GEM-HQL--QPKAQYSPT----QNPHG--FLL O_latipes_ENSORLP00000013892 HLRHLLLGLLQRNHKERMDF--DEFFCHPFLEASSSVKKT----APTATMTCLPSSASASSCSSSSTSHLASPP---SL---------AET-Q----RAKAVASPT----QEATG--FLL G_aculeatus_ENSGACP00000017889 QLGHLLLGLLQRNQKDRMDF--DAFFSHPFLEPLSTIKKS-----CPVPVPSASNAVTDSSCGSSPSIRYNSPP---SL---------PDM-QTL--AEDGLSSPP----LGPPN--FLQ M_musculus_ENSMUSP00000108029 PLRQLLLALLQRNHKDRMDF--DEFFHHPFLDASTPIKKS-----PPVPVPSYPSSGSGSSSSSSSASHLASPP---SL---------GEM-PQ---LQKTLTSPA-----DAAG--FLQ H_sapiens_ENSP00000324560 PLRQLLLALLQRNHKDRMDF--DEFFHHPFLDASPSVRKS-----PPVPVPSYPSSGSGSSSSSSSTSHLASPP---SL---------GEM-QQ---LQKTLASPA-----DTAG--FLH R_norvegicus_ENSRNOP00000053633 PLRQLLLALLQRNHKDRMDF--DEFFHHPFLDASTPIKKS-----PPVPVPSYPSSGSGSSSSSSSASHLASPP---SL---------GEM-PQ---LQKTLTSPA-----DAAG--FLQ O_anatinus_ENSOANP00000020106 YLTDLLLNLLQRNQKDRMDF--EAFFCHPFFEQVP-VKKS-----CPVPVPIYAGSVSGSSCG-SPSCRFASPP---SL---------PDM-QHI--QEDNLSSPP----LGPPN--FLQ T_rubripes_ENSTRUP00000029855 DLKDLLLGLLQRNHQERISFVTEEFFHHPFLETSSTTKKS--------PTLSYPSSASASSSCSSSTSHLASPQ---SN---------LAQ-QQE--TAVSLTSHS----DGELN--QIQ O_latipes_ENSORLP00000017355 NLRHLLLGLLQRNHKERITF--DEFFHHPFLETSTSTKKC-----LLVAPISYLTSASGSSSSSSSTSQLASPQ---KC---------SDG-ETH--QPKEMHSPA----EDTAG--SLL B_taurus_ENSBTAP00000017268 PLRQLLLALLQRNHKDRMDF--DEFFHHPFLDASATVKKS-----PPVPVPSYPSSGSGSSSSSSSTSHLASPP---SL---------GEMQQE---LQKTLTSPA-----EAAG--FLH G_aculeatus_ENSGACP00000023344 HLRHLLLGLLQRNHKDRMDF--DEFFCHPFLEASSSLKKS----TPAVSMTCIPSSASASSCSSSSTSHLASPP---SL---------AEG-QHL--RAKALASPT----QEAAG--FLL E_caballus_ENSECAP00000007293 YLANLLLGLLQRNQKDRMDF--EAFFSHPFLEQVP-VKKS-----CPVPVPVYAGSVSGGSCGSSPSCRFASPP---SL---------PDM-QHI--QEENLSSPP----LGPPN--YLQ M_domestica_ENSMODP00000031918 PLRQLLLGLLQRNHKDRMDF--DEFFHHPFLDASSSIKKS-----PPVPMPSYPS--SGSSSSSSSASHLASPP---SL---------GEMQQQ---LQKTLTSPA----PDPGG--FLQ M_mulatta_ENSMMUP00000027852 YLANLLLGLLQRNQKDRMDF--EAFFSHPFLEQVP-VKKS-----CPVPVPVYSGSVSGSSCGSSPSCRFASPP---SL---------PDM-QHI--QEENLSSPP----LGPPN--YLQ A_carolinensis_ENSACAP00000000717 YLADLLLALLQRNQKDRMDF--EAFFNHPFLDQVSTVKKS-----CPVPVPAYTGSVSGSSCGSSPSCRFASPP---VS---------SIL-TFP--SLAARRSHP----CSSQG--YRR P_pygmaeus_ENSPPYP00000009920 YLANLLLGLLQRNQKDRMDF--EAFFSHPFLEQVP-VKKS-----CPVPVPMYSGSVSGSSCGSSPSCRFASPP---SL---------PDM-QHI--QEENLSSPP----LGPPN--YLQ C_familiaris_ENSCAFP00000026786 YLANLLLGLLQRNQKDRMDF--EAFFSHPFLEQVP-VKKS-----CPVPVPVYAGSVSGSSCGSSPSCRFASPP---SL---------PDM-QHI--QEENLSSPP----LGPPN--YLQ C_familiaris_ENSCAFP00000009679 PLRQLLLALLQRNHKDRMDF--DDFFHHPFLDASATVKKS-----PPVPVPSYPSSGSGSSSSSSSTSHLASPP---SL---------GEMHQQ---LQKTLTSPA-----DAAG--FLQ E_caballus_ENSECAP00000014390 PLRQLLLALLQRNHKDRMDF--DEFFHHPFLDASATVKKS-----PPVPVPSYPSSGSGSSSSSSSTSHLASPP---SL---------GEMQQQ---LQKTLTSPA-----DAAG--FLQ P_pygmaeus_ENSPPYP00000005848 PLRQLLLALLQRNHKDRMDF--DEFFHHPFLDASPSVRKS-----PPVPVPSYPSSGSGSSSSSSSTSHLASPP---SL---------GEM-QQ---LQKTLTSPA-----DTAG--FLH T_guttata_ENSTGUP00000008305 HLRQLLLGLLQRNHKDRMDF--DEFFHHPFLDASASMKKS-----ASVPMPSYPSSGSGSSSSSSSTSHLASPP---SL---------GEMQQQL--QEKALASPT----QDSPG--FLH M_mulatta_ENSMMUP00000020714 PLRQLLLALLQRNHKDRMDF--DEFFHHPFLDASPSVRKS-----PPVPVPSYPSSGSGSSSSSSSTSHLASPP---SL---------GEM-QQ---LQKTLTSPA-----DAAG--FLH P_troglodytes_ENSPTRP00000009595 PLRQLLLALLQRNHKDRMDF--DEFFHHPFLDASPSVRKS-----PPVPVPSYPSSGSGSSSSSSSTSHLASPP---SL---------GEM-QQ---LQKTLASPA-----DTAG--FLH S_cerevisiae_YGL180W ELKELICSLLTFDPAQRIGF--EEFFANKVVNEDLSSYE------LEDDLPELESKSKGIVESNMFVSEYLSKQ---PKSPNSNLAGHQSMADNP--AELSDALKN-------------- P_pygmaeus_ENSPPYP00000014729 CFKNFLQGLLTKDPRQRLSW--PDLLYHPFIAGHVTIITETAGPDLGTPFTSRLPPELQVLKDKQ-AHRLSPKG---NQ---------SRILTQA--YERMAEEAM-------------- M_mulatta_ENSMMUP00000008885 CFKNFLQGLLTKDPRQRLSW--PDLLHHPFIAGRVTIITEPAGPDLGTPFTSRLPPELQVLKDEQ-AHRLAPKG---NQ---------SRILTQA--YKRMAEEAK-------------- P_troglodytes_ENSPTRP00000022091 CFKNFLQGLLTKDPRQRLSW--PDLLYHPFIAGHVTIITESAGPDLGTPFTSRLPPELQVLKDEQ-AHRLAPKG---NQ---------SRILTQA--YKRMAEEAM-------------- H_sapiens_ENSP00000295709 CFKNFLQGLLTKDPRQRLSW--PDLLYHPFIAGHVTIITEPAGPDLGTPFTSRLPPELQVLKDEQ-AHRLAPKG---NQ---------SRILTQA--YKRMAEEAM-------------- O_cuniculus_ENSOCUP00000001738 CFKNFLQGLLTKDPRQRLSW--PDLLHHPFIAGRVTIVTEPAGPDLGTPFTSRLPPELQVLKDEQ-AHRLAPKG---SQ---------SRILRQA--YKRMAEAAK-------------- B_taurus_ENSBTAP00000038069 CFKNFLQGLLTKDPRQRLSW--PDLLHHPFIAGRVTILTEPAGPDFGTPFTSRLPPELQVLKDQQ-AHRLAPKG---NR---------SHILRQA--CKRMAEEAK-------------- C_familiaris_ENSCAFP00000021994 CFKSFLQGLLTKDPRQRLSW--PDLLHHPFIAGRVTIITEPGGSDLGTPFTSHLPPELQVLKEQQ-VHRLAPKG---NR---------SRILRLA--CKRMAEEAK-------------- G_gallus_ENSGALP00000018526 AFKSFLQGLLMKDPHQRLSW--PELLSHPFVAGRVTVIDDTEEHGISNPFTTKLSPELQALKEQQ-AHSLAPRS---GQ---------SRILRKA--RQKMAEEAQ-------------- R_norvegicus_ENSRNOP00000022839 CFKNFLQGLLTKDPRQRLSW--PDLLHHPFIAGRVTIITEPAGSNLGTPFTSRLPPELQVLKDEQ-AHRLAPKG---NQ---------SRILRQA--CKRMAEEAK-------------- E_caballus_ENSECAP00000008449 CFKNFLQGLLTKDPRQRLSW--PDLLHHPFIAGHVTIITEPAGSDLGTPFTSRLPPELQVLKDQQ-AHRLVPKG---NQ---------FRILRQA--CKRMAEELK-------------- M_musculus_ENSMUSP00000084430 CFKNFLQGLLTKDPRQRLSW--PDLLHHPFIAGRVTIITEPAGSDLGTPFTSRLPPELQVLKDEQ-AHRLAPKG---NQ---------SRILRQA--CKLMAEEAK-------------- M_domestica_ENSMODP00000019211 CFKSFLQGLLTKDPRQRLSW--PELLYHPFIAGRVTMTSETVTSDLGTPFTSRLPLELQALKEEQ-TNWLTPKG---GQ---------SRILRQA--RKRMAEDTR-------------- A_carolinensis_ENSACAP00000002909 HFKSFLQGLLMKNPHERLSW--PELLYHPFIAGKVTVIDDTVDQGIVNPFTSKLPPDLQALKEQQ-AHSLTPPS---GQ---------SKILRKA--RQKMAQEAR-------------- G_gorilla_ENSGGOP00000001881 CFKNFLQGLLTKDPRQRLSW--PDLLYHPFIAGRVTIITEPAGPDLGTPFTSRLPPELQVLKDEQ-AHRLAPKG---NQ---------SRILTQA--YKRMAEEAI-------------- G_aculeatus_ENSGACP00000012128 DCEHLIRRMLVLDPSKRLSV--AQIKEHKWMALYAPVQRPVL---YQQPLPAEGEARVGEYSEQV-----------------------LRLMHSLGIDQNKTIESL-------------- M_domestica_ENSMODP00000018106 DCEHLIRRMLVLDPSKRLTI--AQIKEHKWMLVEVPIQRPVL---Y--PQEQENEPSLGEYNEQV-----------------------LRLMHSLGIDQQKTMESL-------------- C_intestinalis_ENSCINP00000014205 NFRSFLKGLLTKNPVKRLTW--PFLLKHPFIV---------------------------QAKEKI-AAQVSSKG---GG---------SKILRKA--RQKMAAAEK-------------- D_rerio_ENSDARP00000081199 DCLSFLKGLLMKEPEKRLSW--PDLLHHPFVADGVLMVSDEG---SSNPLTVPPSPDVQALKHQQVAEKTTVRS---GE---------GKLLGKA--RELREKEKT-------------- T_rubripes_ENSTRUP00000036932 DCEHLIRRMLVLDPSKRLSV--AQIKQHKWMAPYVPVQRPVL---HQQPLSAEGEAGIGEYSEQV-----------------------LRLMHSLGIDQHKTIESL-------------- D_rerio_ENSDARP00000011264 SAKDFIRNMMQKNPKMRFNT--EQALRHPWIIGKTARSQD-----IYHSVSEQMQKNFAKSKWKQAFNATVAIN---HM---------KKLQQAH--SEACVRLKD-------------- D_melanogaster_FBpp0112008 ECEQLIRNMLVVEPDRRYTI--KQIIKHRWLSEWQSEMQE-------QERFGDMSPGSGTVSKSASTSSLGSAS---DSPPQLDSVVMTHMLQLPGLTADMIAQSV-------------- D_melanogaster_FBpp0074373 ECRSFLQGLLEKDPGLRISW--TQLLCHPFVEGRIFIAETQAEAAKESPFTN---PEAKVKSSKQSDPEVGDLD---EA---------LAALDFG--ESRQENLTT-------------- 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0075677 DSE-----NNSGSCSSHEDSDDFVLVPKNLP-EDQRQGLAQVQAQPASGGQRPQQQQNQ----------------------------------------------------------SSP A_gambiae_AGAP011295-PA DSVATIS-ANHTSNSSPEESDDFVLVPNNIP-VDPAHGGSYDKSKPTRVPQPMSQAQ------------------------------------------------------------ASP A_aegypti_AAEL003819-PA DSVATIASANNTSNSSQDNSDDFVLVPNNLP-VDPC-SGNYDKSKPTRVPQTASNAQ------------------------------------------------------------ASP C_elegans_Y60A3A.1.1 RRVITPGMPSPVPGAPMQESTDFTFLPPRQE----------------------SSPVKQVQV-------------------------------------------------------HTN D_rerio_ENSDARP00000083843 -LSKESGGSTSSKN-SSCDTDDFVLVPH-LS-GEQSYDL--------PMGAVGRRPSSEFLLCGGN-------------------------------------------------CHTPM R_norvegicus_ENSRNOP00000003792 -VSKDSA-SNSSKN-SSCDTDDFVLVPHNIS-SDHSYDM--------PMGTAGRRASNEFFVCGGQ----C----------------------------------------------QPT P_troglodytes_ENSPTRP00000042372 -VSKDSA-STSSKN-SSCDTDDFVLVPHNIS-SDHSYDM--------PMGTAGRRASNELLVCGGQ----C----------------------------------------------QPT B_taurus_ENSBTAP00000029699 -VSKDSA-STSSKN-SSCDTDDFVLVPHNIS-SDHSYDM--------PMGTAGRRASNEFLVFGGQ----C----------------------------------------------QPS M_musculus_ENSMUSP00000004920 -VSKDSA-SNSSKN-SSCDTDDFVLVPHNIS-SDHSYDM--------PMGTTARRASNEFFMCGGQ----C----------------------------------------------QPT H_sapiens_ENSP00000354877 -VSKDSA-STSSKN-SSCDTDDFVLVPHNIS-SDHSCDM--------PVGTAGRRASNEFLVCGGQ----C----------------------------------------------QPT O_latipes_ENSORLP00000018791 -LSKESAGSTSSKN-SSCDTDDFVLVPH-IA-AD-SYDL--------PV-LLGRRPSNEFLMCGGG----TLLVGAQCLHGGSAPFSSPSGSAFVPQP---------------PQGQTAM T_nigroviridis_ENSTNIP00000017404 -LSKESAGSSSSKN-SSCDTDDFVLVPH-IS-ADSSNLL----------------PPPCPHLCSTC----SPLPPLTVPAAGFTPRLLASCNFQQPQP---------------VSGQTPM T_nigroviridis_ENSTNIP00000008902 -KDSS---GGGSRAWSSCDLEDFVMVPAHFSTADATAD-----------------GLHDSLLTSG-----SLLACAAVSCQSKSQAGSSSS--------------------------CSS M_domestica_ENSMODP00000005348 -VSKDSA-STSSKN-SSCDTDDFVLVPHNIS-SDHSCDKVSLVPPPPPPVFCERGALSDQLFFQNHGCRPC----------------------------------------------QPS T_guttata_ENSTGUP00000007355 -VSKDSA-STSSKN-SSCDTDDFVLVPHNIS-SDHSYDM--------PLGAAGRRASSEFLMCGGH----C----------------------------------------------QPS T_rubripes_ENSTRUP00000015470 -LSKESAGSTSSKN-SSCDTDDFVLVPH-IS-AD-SYDQ--------PMG-VGRRPSSEFLMCGGL---------------------GTSAVFSESHPCFPSQLPALSGGKHQSGRKTPM O_anatinus_ENSOANP00000021856 -RSKDSA-GSSSKN-SSCDTDDFVMVPAQFP-SDIAAE------------AAGGKPVQDSLMYSGS----SLVTSAGLESQGQTPSPSPPY--------------------------GNS G_gallus_ENSGALP00000007513 -VSKDSA-STSSKN-SSCDTDDFVLVPHNIS-SDHSYDM--------PLGAAGRRASSEFLMCGGH----C----------------------------------------------QPS G_gallus_ENSGALP00000003776 -GSKDSA-GSSSKN-SSCDTDDFVMVPAQFS-SEMTAE------------AAGGKPIQDSLMYSGS----SLVTSAGLESQGRTPSPSPPY--------------------------SSS G_aculeatus_ENSGACP00000016289 -KEKA---NQDSKS-TSSYSEDYVMVQTQFP-SGCTCE------------LEVGSPIDSCLIYSGS----SPLAERCLRNAGKTPPPSPLL--------------------------HPR O_latipes_ENSORLP00000013892 -KDSSGG-GGSSKNSSSCDTDDFVIVPAHFTTGELTCE---------------SKVLQDSLMNSDR----SLLASAGLSNQAKTPPHSPTY--------------------------SGS G_aculeatus_ENSGACP00000017889 -LSKESAGSTSSKN-SSSDTDDFVLVPH-LS-TD-SYDQ--------PMG-TGRRTSTEFLMYGGQ-----------------------------PHP---------------TQGQPAP M_musculus_ENSMUSP00000108029 -GSRDS--GGSSKD--SCDTDDFVMVPAQFP-GDLVAE------------AASAKPPPDSLLCSGS----SLVASAGLESHGRTPSPSPTC--------------------------SSS H_sapiens_ENSP00000324560 -SSRDS--GG-SKD-SSCDTDDFVMVPAQFP-GDLVAE------------APSAKPPPDSLMCSGS----SLVASAGLESHGRTPSPSPPC--------------------------SSS R_norvegicus_ENSRNOP00000053633 -GSRDS--GGSSKD--SCDTDDFVMVPAQFP-GDLVPE------------AASAKPPPDSLLCSGS----SLVASAGLESHGRTPSPSPTC--------------------------SSS O_anatinus_ENSOANP00000020106 -VSKDSA-STSSKN-SSCDTDDFVLVPHNIS-SDHSYDM--------PMGTAGRRASSEFLVCGGQ----C----------------------------------------------QPS T_rubripes_ENSTRUP00000029855 LKEEADMVCDNGRD-TPSDLEEYVMVPAQFP-SEYTCE------------GVAASPIESCVIYSGK------------------------------------------------------ O_latipes_ENSORLP00000017355 -KEKA---NPDIRN-TLSYAEDYVMVPAQYL-SEYTYE--------------MESTNESCLMC------------------------------------------------------RFI B_taurus_ENSBTAP00000017268 -GSRDS--GGSSKD-SSCDTDDFVMVPAQFP-GDLVAE------------AAGAKPPPDSLMCSGS----SLAASTGLDSRGRTPSPSPPC--------------------------GSS G_aculeatus_ENSGACP00000023344 -KDSSGG-AGSSKNSSSCDTDDFVMVPAHFTTGELTCE---------------SKVLQDSLMNSGS----SLLASAGLCGQVKTPPQSPPC--------------------------SGS E_caballus_ENSECAP00000007293 -VSKDSA-STSSKN-SSCDTDDFVLVPHNIS-SDHSYDM--------PVGTVGRRASNEFLVCGGQ----C----------------------------------------------QPT M_domestica_ENSMODP00000031918 -GSKDS--GGSSKN-SSCDTDDFVMVPAQFP-SKTRWE------------RLGRVGNRSILMCTSG----SVCA---------------------------------------------- M_mulatta_ENSMMUP00000027852 -VSKDSA-STSSKN-SSCDTDDFVLVPHNIS-SDHSYDM--------PLGTAGRRASNEFLVCGGQ----C----------------------------------------------QPT A_carolinensis_ENSACAP00000000717 -VVGLSY-NSGEER-LE---EDCIAVLGTPS-GSNPYDM--------PLAATGRRGSREFLMCGGG-EAPC---------------------------------------------QPPA P_pygmaeus_ENSPPYP00000009920 -VSKDSA-STSSKN-SSCDTDDFVLVPHNIS-SDHSNDM--------PMGTAGRRASNEFLVCGGQ----C----------------------------------------------QPT C_familiaris_ENSCAFP00000026786 -VSKDSA-STSSKN-SSCDTDDFVLVPHNIS-SDHSYDM--------PMGTAGRRASNEFLVCGGQ----C----------------------------------------------QPT C_familiaris_ENSCAFP00000009679 -GSRGS--GGSSKD-SSCDTDDFVMVPAQFP-GDLVAE------------AAGAKPPPDSLMCSGS----SLVASAGLESRGRTPSPSPPCS-------------------------SSS E_caballus_ENSECAP00000014390 -GSRDS--GASSKD-SSCDTDDFVMVPAQFP-GDLVAE------------AAGAKPLPDSLMCSGS----SLVASAGLGSHGRTPSPSPPC--------------------------SSS P_pygmaeus_ENSPPYP00000005848 -SSRDS--GG-SKD-SSCDTDDFVMVPAQFP-GDLVAE------------APSAKPPPDSLMCSGS----SLVASAGLESHGRTPSPSPPC--------------------------SSS T_guttata_ENSTGUP00000008305 -GSKDSA-GSSSKN-SSCDTDDFVMVPAQFS-SDLAAE------------AAGGKPIQDSLMYSGS----SLVTSAGLESQGRTPSPSPPY--------------------------SSS M_mulatta_ENSMMUP00000020714 -SSRDS--GG-SKD--SCDTDDFVMVPAQFP-GDLVAE------------APSAKPPPDSLMCSGS----SLVASAGLESHGRTPSPSPPC--------------------------SSS P_troglodytes_ENSPTRP00000009595 -SSRDS--GG-SKD-SSCDTDDFVMVPAQFP-GDLVAE------------APSAKPPPDSLMCSGS----SLVASAGLESHGRTPSPSPPC--------------------------SSS S_cerevisiae_YGL180W --------SNILTA-PAVKTDHTQAVDKKASNNKYHNS------------LVSDRSFE-------------------------------------------------------------- P_pygmaeus_ENSPPYP00000014729 --------QKKHQN-TGPALEQE-DKTSKVAPGTAPLP------------RLGATPQE-----------------------------------------------------------SS- M_mulatta_ENSMMUP00000008885 --------QKKHQN-TGPALEQE-DKTSKVAPGTAPLP------------RLGATPQE-----------------------------------------------------------SS- P_troglodytes_ENSPTRP00000022091 --------QKKHQN-TGPALEQE-DKTSKVAPGTAPLP------------RLGATPQE-----------------------------------------------------------SS- H_sapiens_ENSP00000295709 --------QKKHQN-TGPALEQE-DKTSKVAPGTAPLP------------RLGATPQE-----------------------------------------------------------SS- O_cuniculus_ENSOCUP00000001738 --------QKKHQS-TGRAPEQE-DRTSQAAADTAPLP------------RPRGTPQE-----------------------------------------------------------AS- B_taurus_ENSBTAP00000038069 --------QKKHQN-TEPPLEQE-DRTSKVAPGTAPLP------------KLKDTPQE-----------------------------------------------------------PG- C_familiaris_ENSCAFP00000021994 --------RKKHQN-TGPALEQE-DRTSKMASGTAPLP------------RLRATPQE-----------------------------------------------------------PG- G_gallus_ENSGALP00000018526 --------KKVEKS-VGFS-----GLHPMVMSKEGLLN------------GTEAALEE-----------------------------------------------------------EVE R_norvegicus_ENSRNOP00000022839 --------QKEDQN-TGSTLDQE-ARLSKVTPSTAPVP------------GLKATPQE-----------------------------------------------------------SS- E_caballus_ENSECAP00000008449 --------QKRHQN-TGPALEQE-DRTSKVASGTASPP------------RLRATPQE-----------------------------------------------------------SG- M_musculus_ENSMUSP00000084430 --------QKEDQN-AGSALEQE-DGLCKVTPSTAPVP------------GLKATPQE-----------------------------------------------------------SS- M_domestica_ENSMODP00000019211 --------QKTHLN-PGTSLEQV-EKASKAVPVAALLP------------RLGATSQD-----------------------------------------------------------LD- A_carolinensis_ENSACAP00000002909 --------RKEMGK-PKASLKGEVSKESETYSRKACLA------------QTDSSRQH-----------------------------------------------------------QK- G_gorilla_ENSGGOP00000001881 --------QKKHQN-TGPALEQE-DKTSKVAPGTAPLP------------RLGATPQE-----------------------------------------------------------SS- G_aculeatus_ENSGACP00000012128 --------QNKSYN-HFAAIYYLLVERLKAHRCSFPVE------------QRLDARQR-------------------------------------------------------------- M_domestica_ENSMODP00000018106 --------QNKSYN-HFAAIYYLLVERLKSHRSSFPVD------------QRVDARQR-------------------------------------------------------------- C_intestinalis_ENSCINP00000014205 --------EKKSLK-S----------------------------------ETHKTEEN-------------------------------------------------------------- D_rerio_ENSDARP00000081199 --------NRREVA-SGSAARCKTASAGGASNTGHSLG------------STFSVYQN-------------------------------------------------------------- T_rubripes_ENSTRUP00000036932 --------QNKSYN-HFAAIYYLLVERLKAHRCSFPVE------------QRLDARQR-------------------------------------------------------------- D_rerio_ENSDARP00000011264 ---------------SPRDVPEIKVIASSTP-ESVRKK------------LLSETPEP-------------------------------------------------------------- D_melanogaster_FBpp0112008 --------HEQRFD-NIYAIYNLLHDKLQQRRREN---------------QRLQHHAS-------------------------------------------------------------- D_melanogaster_FBpp0074373 --------SRDSIN---------------------------------------------------------------------------------------------------------- 610 620 630 640 650 660 670 680 690 700 710 720 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0075677 PRPSSL----------------PISEPKPVPAPAR---RQVARPGP--------------------------------------LTVATLG----------------------------- A_gambiae_AGAP011295-PA PRPSTL----------------PISEPKPVPTAARKVSRAQAQTPP-------------------------------KVCVCVCVCVANIAFALRSS----------------------- A_aegypti_AAEL003819-PA PRPSSL----------------PISEPKPVPTSARKISRQQSQTPP-----------------------------------------KNIP----------------------------- C_elegans_Y60A3A.1.1 VSPSL-----------------TTCKPVPVPSQRLTYQKMEERLAA----------------ARKTAVP---------------SSSSPTGSAVSAQHQ--------------------- D_rerio_ENSDARP00000083843 VSPR------------------SETTPIPVPTQVRNYQRIKQNLSS-------------SPTTTLYGSP--R-----SGTVRR-SNTSPMGFPKMVSASPSP--ADTVQT-VGRRLSTG- R_norvegicus_ENSRNOP00000003792 VSPH------------------SETAPIPVPTQVRNYQRIEQNLIS-----------TASSGTNPHSSP--R-----SAVVRR-SNTSPMGFLRVGSCSPVP--ADTVQT-GGRRLSTG- P_troglodytes_ENSPTRP00000042372 VSPH------------------SETAPIPVPTQIRNYQRIEQNLTS-----------TASSGTNVHGSP--R-----SAVVRR-SNTSPMGFLRPGSCSPVP--ADTAQT-VGRRLSTG- B_taurus_ENSBTAP00000029699 VSPH------------------STAAPIPVPTQVRNYQRIEQNLTS-----------TAGSSTNLHGSP--R-----SAVVRR-SNTSPLGFLRPGSCSPAP--ADAVPA-IGRRLSTG- M_musculus_ENSMUSP00000004920 VSPH------------------SETAPIPVPTQVRNYQRIEQNLIS-----------TASSGTNPHGSP--R-----SAVVRR-SNTSPMGFLRVGSCSPVP--GDTVQT-GGRRLSTG- H_sapiens_ENSP00000354877 VSPH------------------SETAPIPVPTQIRNYQRIEQNLTS-----------TASSGTNVHGSP--R-----SAVVRR-SNTSPMGFLRPGSCSPVP--ADTAQT-VGRRLSTG- O_latipes_ENSORLP00000018791 VSPR------------------AETTPIPVPTQVRNYQRIKQNLSS-------------SPTSTLFSSP--R-----SGTVRR-SNTSPMGFPKVGSGSPSA--GDTPQT-VGRRLSTG- T_nigroviridis_ENSTNIP00000017404 VSPR------------------AETTPIPVPTQIRNYQRIKQNLSS-------------SPTTALYSSP--R-----SGTVRR-SNTSPMGFPK-----------NVPQT-IGRRLSTG- T_nigroviridis_ENSTNIP00000008902 PGPIRDRL--------GDVLQAGPSLPIPVPSQQQNFQRLEQNLLS----------------ARPDASP--R----LWSPMRRCSSGNLQGLAGAPEASPCC----QEKVAANRRLSLG- M_domestica_ENSMODP00000005348 PSPH------------------SETAPIPVPTQLRNYQRIEQNLTS------------ASPGTNPHGSP--R-----SAVVRR-SNTSPLGFLKMGSCSPVP--ADTVQP-AGRRLSTG- T_guttata_ENSTGUP00000007355 VSPR------------------SETAPIPVPTQLRNYQRIEQNLSS-----------TASPVSNPHGSP--R-----AGVVRR-SNTSPMGFMKMGSCSPVP--ADTAQG-VGRRLSTG- T_rubripes_ENSTRUP00000015470 VSPR------------------AETTPIPVPTQIRNYQRIKQNLSS-------------SPTTTLYSSPSLR-----AGTVRR-SNTSPMGFPKVGSGSPNS--ADVPQT-IGRRLSIG- O_anatinus_ENSOANP00000021856 PSPSGRPGPFSGSKY-------GPSIPIPVPTQIQNYKRIEQNLQS----------------PIQYTPP--R--LRRQTAEQNKTRQKPLPFLPHAPSPPKPSSGLTGRARSDQPIRRS- G_gallus_ENSGALP00000007513 VSPR------------------SETAPIPVPTQLRNYQRIEQNLSS-----------TASPVSNPHGSP--R-----AGVVRR-SNTSPMGFMKMGSCSPIP--GDTAQG-VGRRLSTG- G_gallus_ENSGALP00000003776 PSPSSRPGQFSSSKY-------GHSVPIPVPTQIHNYRRIEQNLQS----------------PHQYASP--R-----SGTVRRSSSTSPLGFPKTGASPPYP--GEHGSVPSSRKLSFG- G_aculeatus_ENSGACP00000016289 SKPISKPVAIVGRKC-------ISSAPIPVPTQIQNYQRMAQNLQS----------------VGLHGST--RYVQPLGCIISTPTSVSWVTLCCAGSSSPQQ-GGSPGFILDSLRLASV- O_latipes_ENSORLP00000013892 PSPI-RLTEFPGSNYGGNYGNQGESLPIPVPSQVQNYLRLEENLSS----------------TKQDGSP--R----LSTPVRRCSSGSVVGFTRPGPPPSCV----QGSSPTSRRLSLG- G_aculeatus_ENSGACP00000017889 VSPR------------------AETTPIPVPTQIRNYQRIKQNLSS-------------SPTTMVFSSP--R-----SGTVRR-SNTSPMGLAKMGSGSPSS--ADVPQI-VSRRLSTG- M_musculus_ENSMUSP00000108029 PSPSGRPGPFSSNRY-------GASVPIPVPTQVHNYQRIEQNLQS----------------PTQQQTA--R-----SSAIRRSGSTSPLGFGRASPSPPSH--TD-GAM-LARKLSLG- H_sapiens_ENSP00000324560 PSPSGRAGPFSSSRC-------GASVPIPVPTQVQNYQRIERNLQS----------------PTQFQTP--R-----SSAIRRSGSTSPLGFARASPSPPAH--AEHGGV-LARKMSLG- R_norvegicus_ENSRNOP00000053633 PSPSGRPGPFSSNRY-------GASVPIPVPTQVHNYQRIEQNLQS----------------PTQQQTA--R-----SSAIRRSGSTSPLGFGRASPSPPSH--TD-GAM-LARKLSLG- O_anatinus_ENSOANP00000020106 LSPR------------------SETAPIPVPTQLRNYQRIEQNLTS-----------TGSPGSNPHGSP--R-----SAVVRR-SNTSPMGFLKMGSCSPVP--ADTVQT-IGRRLSTG- T_rubripes_ENSTRUP00000029855 ------PARPVGFTS-------CQTVPVPVPTQIQNYQRLKQNLQP-------------------VGCT--RYMKLLHRIGVRSWLIIPL--------------PQSISVFTGARSATK- O_latipes_ENSORLP00000017355 CKPRSSPVKLDGPAR-------SKSVPIPVPTQIQNYQRMNQNLQH----------------AGMHGST--RHVH------ITVLSLQAMACCTLGSRGSR--------VDCGMRRASA- B_taurus_ENSBTAP00000017268 LSPSGRTGTFSSSRC-------GASVPIPVPTQVQNYQRIEQNLQS----------------PTQYQTA--R-----SSAIRRSGSTSPLGFARASPSPPSH--AEHGAA-LARKLSLG- G_aculeatus_ENSGACP00000023344 PSPVSRPSEFSGSSCGGSYGNHCRSSPIPVPSQVQNYQRMEQNMHC----------------TRLDGSP--R----PSAPVRRCSSGSSLGFARAGPSPPCG----QGAAHANRRLSLG- E_caballus_ENSECAP00000007293 VSPH------------------SEAAPIPVPTQIRNYQRIEQNLTS-----------AASSGTNLHGSP--R-----STVVRR-SNTSPMGFLRLGSCSPAP--ADTVQT-VGRRLSTG- M_domestica_ENSMODP00000031918 -----------FSRY-------GPSVPIPVPTQIQNYRRIEQNLQS----------------PNQYTPPPPR-----SGMVRRSSSTSPLGF-KTGISPPSF--PEHGAT-FPRKSSLG- M_mulatta_ENSMMUP00000027852 VSPH------------------SETAPIPVPTQIRNYQRIEQNLTS-----------TASSGTNVHGSP--R-----SAVVRR-SNTSPMGFLRLGSCSPVP--ADTAQT-VGRRLSTG- A_carolinensis_ENSACAP00000000717 VSPR------------------SETAPIPVPTQLRNYQRIEQNLTSA---------AAASPSSNPHGSP--R-----SGVVRR-SNTSPMGFLKTGSCSPVP--AD------GRRLSTGS P_pygmaeus_ENSPPYP00000009920 VSPH------------------SETAPIPVPTQIRNYQRIEQNLTS-----------TASSGTNVHGSP--R-----SAVVRR-SNTSPMGFLRLGSCSPVP--ADTAQT-VGRRLSTG- C_familiaris_ENSCAFP00000026786 VSPH------------------SETAPIPVPTQIRNYQRIEQNLTS-----------TASSGTNLHGSP--R-----STVVRR-SNTSPMGFLRLGSCSPAP--ADTVQT-VGRRLSTG- C_familiaris_ENSCAFP00000009679 PSPSGRAGPF-SSRC-------GVSVPIPVPTQVHNYQRIEQNLQS----------------PTQYQTT--R-----SSAIRRSGSTSPLGFARASPSPPSH--TEHGAA-LTRKLSLG- E_caballus_ENSECAP00000014390 PSPSGRAGPFSSSRC-------GASVPIPVPTQVQNYQRIEQNLQS----------------PTQCQAQ--R-----SSAIRRSGSTSPLGFARASPSPPSH--AEHGAA-LARKLSLG- P_pygmaeus_ENSPPYP00000005848 PSPSGRAGPFSSSRC-------GASVPIPVPTQVQNYQRIERNLQS----------------PTQFQTP--R-----SSAVRRSGSTSPLGFARASPSPPAH--AEHGGV-LARKMSLG- T_guttata_ENSTGUP00000008305 PSPSGRPGQFSSSKY-------GHSVPIPVPTQIHNYRRIEQNLQS----------------PNPFSSP--R-----SATVRRSSSTSPLGFPKTGASPPYP--GEHGSMPSTKKLSFG- M_mulatta_ENSMMUP00000020714 PSPSGRAGPFSSSRC-------GASVPIPVPTQVQNYQRIERNLQS----------------PTQFQTP--R-----SSAVRRSGSTSPLGFARASPSPPAH--AEHGGV-LARKMSVG- P_troglodytes_ENSPTRP00000009595 PSPSGRAGPFSSSRC-------GASVPIPVPTQVQNYQRIERNLQS----------------PTQFQTP--R-----SSAIRRSGSTSPLGFARASPSPPAH--AEHGGV-LARKMSLG- S_cerevisiae_YGL180W --------------REYVVVEKKSVEVNSLADEVAQAGFNPNPIKH-----------------------------------PTSTQNQNVLLNEQFSPNNQQ------------------ P_pygmaeus_ENSPPYP00000014729 -LLAGILA----SELKSSWAESGTGEAPSAPRENRTTPDCERAFPEE---------RPEV-------------------LGQRSTDAVDLEDEEPDSDNEWQHLL---------ETTEP- M_mulatta_ENSMMUP00000008885 -LLAGILA----SEMKSSWVESETGEAPPAPRENWTTPDCGQAFPEE---------RPEV-------------------LGQRGTDAVDLENEEPDSDNEWQHLL---------ETTEP- P_troglodytes_ENSPTRP00000022091 -LLAGILA----SELKSSWAESGTGEVPSAPRENRTTPDCERAFPEE---------RPEV-------------------LGQRSTDVVDLENEEPDSDNEWQHLL---------ETTEP- H_sapiens_ENSP00000295709 -LLAGILA----SELKSSWAKSGTGEVPSAPRENRTTPDCERAFPEE---------RPEV-------------------LGQRSTDVVDLENEEPDSDNEWQHLL---------ETTEP- O_cuniculus_ENSOCUP00000001738 -LLAGILA----SEMKSSWAEWGPGEAPPAPRENRSTADGGQGFAEP---------RPEA-------------------VSPRSISAVKPENEEPDSDEEWQHLL---------ETLEP- B_taurus_ENSBTAP00000038069 -LLTGVVA----SEMKSSWAEWGAGEAPPAPRENWITQDCEQVFPEL---------RPEV-------------------KGQQSLDAVDLENEEQDSDDEWQYLL---------ETTEP- C_familiaris_ENSCAFP00000021994 -LIAGILA----SEMKSSWAEWGAGETPPAPRENQITQDCEQADPEL---------RPEV-------------------VGQQSIDAVDLENEEPDSDDEWQHLL---------KTGEP- G_gallus_ENSGALP00000018526 LPPSFKEKKSGVLQGKNSMAEWQLKEPPPSPREHSITQDYEREFPQPEAPLQLAVGKAEL-------------------RGRQSIKAVDLESEEQESDEEWQHLI---------EATEP- R_norvegicus_ENSRNOP00000022839 -LLAGLLA----SEMKNNWEDWGAGEAPPTPRENHITLECEQAFPEL---------RPET-------------------MGRRSTDAVDPENEEPDSDDEWQRLL---------ETMEP- E_caballus_ENSECAP00000008449 -LLAGILA----SEMKSSWAECGAGEDPPAPRENWTTQDCERAFPEL---------RPEV-------------------MGQQSIDAVDLENEEPDSDDEWKHLL---------ETSKP- M_musculus_ENSMUSP00000084430 -LLAGILA----SEMKNNWEDWGAGEAPRTSRENHINLECEQGFPEP---------RPEA-------------------MGRQSTDVVDPENEEPDSDDEWQRLL---------ETSEP- M_domestica_ENSMODP00000019211 -FLSRTPS----PEDKKDWAEWEASEPPQPTREPQVTQEYDQEFPEL---------KQEA----------------------EESSVGTLEPEEPDSDSEWQHLL---------EPTAP- A_carolinensis_ENSACAP00000002909 -LPGMEEH----LALGEKETEWEQKEPSSKLQENWITQDYEREFQEM---------KPES---------------------RRSIDTVDLETEEMDSDEEWQHFI---------DATNS- G_gorilla_ENSGGOP00000001881 -LLAGILA----SELKSSWAESGTGEVPSAPRENRTTPDCERAFPEE---------RPEV-------------------LGQQSTDVVDLENEXXXXXXXXXXXX---------XXXXX- G_aculeatus_ENSGACP00000012128 --------------RPSTIAEQTVVKPSSGSAQVGLLPQGVRLLRS--------------------------------PAVPQASS-DGFTFPQSACLLEQNFLVED-VNTPKVNG---- M_domestica_ENSMODP00000018106 --------------RPSTVAEQTVAKAQTVGPPMAIRSPNMRLMRS--------------------------------PILPQTSNVEVFSFPNSGCQADAAFMEEERVDTPKVNG---- C_intestinalis_ENSCINP00000014205 --------KSKNQSNKSKLPQIQTKTKKPAKREVSSATKSKQIEKE---------------------------------KLPNMKQLSLQDQSVEDSDDDWQEII---------DATDP- D_rerio_ENSDARP00000081199 --------SSQPATNRHQANDNSVTRARSAPHKGQISRDYAREFPSV---------E----------------------VGPRQFLKRPGHEQDMDSDYEWQRLV---------ELSDQ- T_rubripes_ENSTRUP00000036932 --------------RPSTIAEQTVVKSTSGLTQVGLHPQGVRLLRS--------------------------------SAVPQASS-DVFAFPSAACSLEQNFTVDD-VNTPKVNG---- D_rerio_ENSDARP00000011264 ----------------------NGSMNVPCGSTEAKSQYHPMRVSH-----------------------------------SETTHVGTLTIAEK------------------------- D_melanogaster_FBpp0112008 --------------LAYSRSRKTSITTGVVDRSEPVKQESLDRLSP---------------------------------LSNANASSSALGFGWSDVAVDLEKYG---------DFELE- D_melanogaster_FBpp0074373 -----------------------------------------------------------------------------------AIAPSDVEHLETDVEDNMQRVVVPFADLSYRDLSGV- 730 740 750 760 770 780 790 800 810 820 830 840 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0075677 ----GQQIP--------------------------------------------------------------------------------------------------------------- A_gambiae_AGAP011295-PA LFFQNNSIP--------------------------------------------------------------------------------------------------------------- A_aegypti_AAEL003819-PA -----NAIP--------------------------------------------------------------------------------------------------------------- C_elegans_Y60A3A.1.1 HQHQQQQEP--------------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000083843 SSRPYSPSPL-------------------------------------------------------------------VGTIPEQLGHCCCGHPQSHEPR--------------------- R_norvegicus_ENSRNOP00000003792 SSRPYSPSPL-------------------------------------------------------------------VGTIPEQFSQCCCGHPQGHEAR--------------------- P_troglodytes_ENSPTRP00000042372 SSRPYSPSPL-------------------------------------------------------------------VGTIPEQFSQCCCGHPQGHDSR--------------------- B_taurus_ENSBTAP00000029699 SSRPYSPSPL-------------------------------------------------------------------VGTIPEQFRQCCCGHLQGHESR--------------------- M_musculus_ENSMUSP00000004920 SSRPYSPSPL-------------------------------------------------------------------VGTIPEQFSQCCCGHPQGHEAR--------------------- H_sapiens_ENSP00000354877 SSRPYSPSPL-------------------------------------------------------------------VGTIPEQFSQCCCGHPQGHDSR--------------------- O_latipes_ENSORLP00000018791 SSRPYSPSPLGIR-------------------------------------------------------------FFPVGTIPEQLGHCCC-HLQNQEPR--------------------- T_nigroviridis_ENSTNIP00000017404 SSRPYSPSPLGLF-------------------------------------------------------------VSPVGTIPEQLGHCCC-HLQNHESR--------------------- T_nigroviridis_ENSTNIP00000008902 GARTVPPSSQ-------------------------------------------------------------------RRYVNSAPLWF-------------------------------- M_domestica_ENSMODP00000005348 SSRPYSPSPL-------------------------------------------------------------------VGTIPEQLGHCCCGQPQGHDSR--------------------- T_guttata_ENSTGUP00000007355 SSRPYSPSPL-------------------------------------------------------------------VGTIPEQLGHCCCGQLQGHESR--------------------- T_rubripes_ENSTRUP00000015470 SSRPYSPSPLGLF-------------------------------------------------------------VSSVGTIPEQTSYNLLHSSQGDHCH--------------------- O_anatinus_ENSOANP00000021856 PCRPVLGQTQ-------------------------------------------------------------------VGTIPERPGQSLIPSPQGAELR--------------------- G_gallus_ENSGALP00000007513 SSRPYSPSPL-------------------------------------------------------------------VGTIPEQLGHCCCGQLQGHESR--------------------- G_gallus_ENSGALP00000003776 GAKPFTPSPQVK-----------------------------------------------------------------VGTIPEQPIQTVIPSSLGAEVR--------------------- G_aculeatus_ENSGACP00000016289 GARPQQSSPLGRH--PDRLLFHSFRECFSSTALLQPLLRSHSDRIIGPFGGSLNIPPSLNIFSVPTFPSADLPYNTLAGMTPNTTEQTSPHGTRTGLL---------------------- O_latipes_ENSORLP00000013892 AARTLQLPP---------------------------------------------------------------------------GMYTFFVGLNGKEQRKGERWMLLMRGKECKIKASQQ G_aculeatus_ENSGACP00000017889 SSRPYSPSPL-------------------------------------------------------------------VGTIPEQLGHCCC-HLQNHEPR--------------------- M_musculus_ENSMUSP00000108029 GGRPYTPSPQATL-------------------------------------------------------------FLPVGTIPERPSWSRVPSPQGADVRV-------------------- H_sapiens_ENSP00000324560 GGRPYTPSPQ-------------------------------------------------------------------VGTIPERPGWSGTPSPQGAEMRG-------------------- R_norvegicus_ENSRNOP00000053633 GGRPYTPSPQATL-------------------------------------------------------------FLPVGTIPERPSWSRVPSPQGADVRA-------------------- O_anatinus_ENSOANP00000020106 SSRPYSPSPL-------------------------------------------------------------------VGTIPEQLGHCCCGQPQGHESR--------------------- T_rubripes_ENSTRUP00000029855 CARPQQLSPA-------------------------------------------------------------------VATTPKTPEQALPLGTRTGLL---------------------- O_latipes_ENSORLP00000017355 PAIASFATANFSNVIPGDLYTMKMCCCFISSLLRSHFIFL-----------KTYIPEQFFLTLTLSF------YICVVGQIPKTLEQNFPLSSRTELL---------------------- B_taurus_ENSBTAP00000017268 GGRPYTPSPQ-------------------------------------------------------------------VGTIPERPGWSGAPSPQASEMRG-------------------- G_aculeatus_ENSGACP00000023344 GARPFQPSPQ--------------------------------------------------------------------GTAEASPLWTSSTTAAGEQKHS---------------DLCPP E_caballus_ENSECAP00000007293 SSRPYSPSPL-------------------------------------------------------------------VGTIPEQLSQCCCGHPQGHESR--------------------- M_domestica_ENSMODP00000031918 GAKPYNPSPQGES----------------------------------------------------------------QSLLPRPAGRACVQHTAGSPRRKAPRCVELAAVAGSPDLVAIF M_mulatta_ENSMMUP00000027852 SSRPYSPSPL-------------------------------------------------------------------VGTIPEQFSQCCCGHPQGHDSR--------------------- A_carolinensis_ENSACAP00000000717 SSRPYSPSPL-------------------------------------------------------------------VGTIPEQLGHCCCGQIQGHESR--------------------- P_pygmaeus_ENSPPYP00000009920 SSRPYSPSPL-------------------------------------------------------------------VGTIPEQFSQCCCGHPQGHDSR--------------------- C_familiaris_ENSCAFP00000026786 SSRPYSPSPL-------------------------------------------------------------------VGTIPEQFSQCCCGHPQGHESR--------------------- C_familiaris_ENSCAFP00000009679 GGRPYTPSPQAPL-------------------------------------------------------------SAQVGIIPERPGWSGAPSPQGAEMRG-------------------- E_caballus_ENSECAP00000014390 GGRPYTPSPQAGL------------------------------------------------------------GQGEVGTIPERPGWSRAPSPQGAEMRG-------------------- P_pygmaeus_ENSPPYP00000005848 GGRPYTPSPQ-------------------------------------------------------------------VGTIPERPGWSGTPSPQGAEMRG-------------------- T_guttata_ENSTGUP00000008305 GAKPFMPSPQ-------------------------------------------------------------------VGTIPEQPSQTVTPSSLGAEVR--------------------- M_mulatta_ENSMMUP00000020714 GGRPYTPSPQ-------------------------------------------------------------------VGTIPERPGWSGTPSPQGAEMRG-------------------- P_troglodytes_ENSPTRP00000009595 GGRPYTPSPQ-------------------------------------------------------------------VGTIPERPGWSGTPSPQGAEMWG-------------------- S_cerevisiae_YGL180W YFQNQGENP--------------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000014729 VPIQLKAPL--------------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000008885 VPVQLKAPL--------------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000022091 VPIQLKAPL--------------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000295709 VPIQLKAPL--------------------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000001738 VPIQLKAPL--------------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000038069 VPIQLKAPL--------------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000021994 VPIQLKAPL--------------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000018526 LAMQLSTPL--------------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000022839 VPVQLKSPL--------------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000008449 MPIQLKAPL--------------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000084430 GPVQLKSPL--------------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000019211 SDIQLKAPL--------------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000002909 THVHLSAPL--------------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000001881 XXXXXXXXX--------------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000012128 CLLDPLPPP--------------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000018106 CLLDPVPP---------------------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000014205 GNMQLTTPM--------------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000081199 GPVNASI----------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000036932 CLMDPLPPP--------------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000011264 GKHVYHSEP--------------------------------------------------------------------------------------------------------------- D_melanogaster_FBpp0112008 CLARSNDPP--------------------------------------------------------------------------------------------------------------- D_melanogaster_FBpp0074373 RAMPMVHQP--------------------------------------------------------------------------------------------------------------- 850 860 870 880 890 900 910 920 930 940 950 960 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0075677 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011295-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003819-PA ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y60A3A.1.1 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000083843 ----------------------------------------------------SRSS----SG---G------------------------------------------------------ R_norvegicus_ENSRNOP00000003792 ----------------------------------------------------SRHS----S----G------------------------------------------------------ P_troglodytes_ENSPTRP00000042372 ----------------------------------------------------SRNS----S----G------------------------------------------------------ B_taurus_ENSBTAP00000029699 ----------------------------------------------------SRNS----S----G------------------------------------------------------ M_musculus_ENSMUSP00000004920 ----------------------------------------------------SRHS----S----G------------------------------------------------------ H_sapiens_ENSP00000354877 ----------------------------------------------------SRNS----S----G------------------------------------------------------ O_latipes_ENSORLP00000018791 ----------------------------------------------------SSSGEPSPSS---G------------------------------------------------------ T_nigroviridis_ENSTNIP00000017404 ----------------------------------------------------SRSS----SGAFPG------------------------------------------------------ T_nigroviridis_ENSTNIP00000008902 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005348 ----------------------------------------------------SRNS----S----------------------------------------------------------- T_guttata_ENSTGUP00000007355 ----------------------------------------------------SRNF----S----G------------------------------------------------------ T_rubripes_ENSTRUP00000015470 ----------------------------------------------------GPLP----SP---G------------------------------------------------------ O_anatinus_ENSOANP00000021856 ----------------------------------------------------AWLP----IP---G------------------------------------------------------ G_gallus_ENSGALP00000007513 ----------------------------------------------------SRNF----A----G------------------------------------------------------ G_gallus_ENSGALP00000003776 ----------------------------------------------------SRIP----AA---G------------------------------------------------------ G_aculeatus_ENSGACP00000016289 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000013892 QTES-------------------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000017889 ----------------------------------------------------SRSS----SG---G------------------------------------------------------ M_musculus_ENSMUSP00000108029 ----------------------------------------------------GRSP----RP---G------------------------------------------------------ H_sapiens_ENSP00000324560 ----------------------------------------------------GRSP----RP---G------------------------------------------------------ R_norvegicus_ENSRNOP00000053633 ----------------------------------------------------GRSP----RP---G------------------------------------------------------ O_anatinus_ENSOANP00000020106 ----------------------------------------------------SRNS----S----G------------------------------------------------------ T_rubripes_ENSTRUP00000029855 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000017355 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000017268 ----------------------------------------------------GRSP----RP---G------------------------------------------------------ G_aculeatus_ENSGACP00000023344 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000007293 ----------------------------------------------------SRNS----S----G------------------------------------------------------ M_domestica_ENSMODP00000031918 FLSNSPSYNHRKPFSPPRNSYTLKYYWSLQLIFTGDLGSSRSSLVFSNPGLASRDEWASSLL---G------------------------------------------------------ M_mulatta_ENSMMUP00000027852 ----------------------------------------------------SRNS----S----G------------------------------------------------------ A_carolinensis_ENSACAP00000000717 ----------------------------------------------------SRNS----S----G------------------------------------------------------ P_pygmaeus_ENSPPYP00000009920 ----------------------------------------------------SRNS----S----G------------------------------------------------------ C_familiaris_ENSCAFP00000026786 ----------------------------------------------------SRNS----S----GSLLKGIKLIQNILLSYFLESWSVLAYYIDNENQSRKGNFIPLINTILDYGYRSL C_familiaris_ENSCAFP00000009679 ----------------------------------------------------GRSP----RP---G------------------------------------------------------ E_caballus_ENSECAP00000014390 ----------------------------------------------------GRSP----RP---G------------------------------------------------------ P_pygmaeus_ENSPPYP00000005848 ----------------------------------------------------GRSP----RP---G------------------------------------------------------ T_guttata_ENSTGUP00000008305 ----------------------------------------------------SRVP----AA---G------------------------------------------------------ M_mulatta_ENSMMUP00000020714 ----------------------------------------------------GRSP----RP---G------------------------------------------------------ P_troglodytes_ENSPTRP00000009595 ----------------------------------------------------GRSP----RP---G------------------------------------------------------ S_cerevisiae_YGL180W ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014729 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000008885 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000022091 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000295709 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001738 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000038069 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000021994 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000018526 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000022839 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000008449 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000084430 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000019211 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002909 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000001881 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000012128 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000018106 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000014205 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000081199 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000036932 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000011264 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0112008 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0074373 ------------------------------------------------------------------------------------------------------------------------ 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0075677 ---------------------------RSQPISVK--------------------------------------------QPRPDQRKSSVSSDINSISPPAVQFAIGTPPT--RMRSASG A_gambiae_AGAP011295-PA ---------------------------RSEPINMK----------------------------------------------RSENRGS--NCDIRSISPPAVQFAIGTPPSCGRRRSTSG A_aegypti_AAEL003819-PA ---------------------------RSQPISMK----------------------------------------------RSEHRNS--NCDISSISPPAVQFAIGTPPTGSRRRSTSG C_elegans_Y60A3A.1.1 ---------------------------ASSPVVQRIERPDQLPRRTTLQDPNAHDIERM--------------------TMPNPTFVVCGSST-------KPSPNNANRVRRSTITSPAD D_rerio_ENSDARP00000083843 ---------------------------SPVPSSQ-----L--L-GARLQSAPTLTDIYQ--SKQKLHKQLS--------DPVHPTSSAYPS--NHSPQLGRP-ANLGTSPTKHLGSSPRT R_norvegicus_ENSRNOP00000003792 ---------------------------SPVPQTQSPQSLL--L-GARLQSAPTLTDIYQ--NKQKLRKQHS--------DPVCPSLAGAGY--SYSPQPSRP-GSLGTSPTKHMGSSPRS P_troglodytes_ENSPTRP00000042372 ---------------------------FPVPQAQSPQSLL--S-GARLQSAPTLTDIYQ--NKQKLRKQHS--------DPVCPSHTGAGY--SYSPQPSRP-GSLGTSPTKHLGSSPRS B_taurus_ENSBTAP00000029699 ---------------------------SPVPQAQSPQPVL--L-GARLQSAPTLTDIYQ--NKQKLRKQHS--------DPVCPSQAGAGY--SCSPQPSRP-GSLGTSPTKHTGSSPRS M_musculus_ENSMUSP00000004920 ---------------------------SPVPQTQAPQSLL--L-GARLQSAPTLTDIYQ--NKQKLRKQHS--------DPVCPSHAGAGY--SYSPQPSRP-GSLGTSPTKHTGSSPRN H_sapiens_ENSP00000354877 ---------------------------SPVPQAQSPQSLL--S-GARLQSAPTLTDIYQ--NKQKLRKQHS--------DPVCPSHTGAGY--SYSPQPSRP-GSLGTSPTKHLGSSPRS O_latipes_ENSORLP00000018791 ---------------------------SPIPPSQ-----L--L-GARLQSAPTLTEVYQ--TRQKLHKQLS--------DPVQPSSS---C--SHSPQFGRP-ANLGSSPTKLLGTSPRT T_nigroviridis_ENSTNIP00000017404 ---------------------------SPVPSSQ-----L--L-GARLQSAPTLTEFYQ--SRQKLHKQLS--------DPTQPSSSL--C--SHSPQLGRP-ANLGSSPTKHLGSSPRT T_nigroviridis_ENSTNIP00000008902 ---------------------------PTAPECLLLQPGG--L-GTRLHSAPCLLEYTAAGARQKIRKQHS--------DPAVR-------------------PSPGAMTVCPLHCSPRL M_domestica_ENSMODP00000005348 -----------------------------VPQSQSPQSLL--M-GARLQSAPTLTDIYQ--NKQKLRKQHS--------DPVCPSQAGFGY--SYSPQPSRP-VSLGTSPTKHMGSSPRS T_guttata_ENSTGUP00000007355 ---------------------------SPIPPSQSPQSLL--M-GARLQSAPTLTDIYQ--NKQKLRKQHS--------DPVCPSYAGYGY--SHSPQPSRP-GSLGTSPTKHMGSSPRS T_rubripes_ENSTRUP00000015470 ---------------------------SPFPSSQ-----L--L-GARLQSAPTLTEFYQ--TRQKLHKQLS--------DPIQPSSSL--C--SHSPQLGRP-ANLGSSPTKLLGSSPRT O_anatinus_ENSOANP00000021856 ---------------------------ASLPE-PSTR--G--L-GSRLHSAPNLSDLHV--VRPKLPKPPS--------EPLVAACG--------HAQASPP---HGLQACRPLRSSPKL G_gallus_ENSGALP00000007513 ---------------------------SPIPPSQSPQSLL--M-GARLQSAPTLTDIYQ--NKQKLRKQHS--------DPVCPSYAGYGY--SHSPQPSRP-GSLGTSPTKHMGSSPRS G_gallus_ENSGALP00000003776 ---------------------------ASAPE-HSPR--G--M-GSRLHSAPNLSDLHS--CRQKITKQHS--------DPLVAHFV--------HTPVSQPLQIHGLQHCRQLRSSPKL G_aculeatus_ENSGACP00000016289 ---------------------------AGFPDRKDTPSPKVGLQPVRCVDVCSFV-------SPSIQPKSLLLCTFYVVQSRMPNRIRTVLDLQSLEPSPASQTNRSSKSLNKNGPFRRS O_latipes_ENSORLP00000013892 ---------------------------RPIPQ-QSPQAAG--L-GSRLHSAPCLLECASGGSRHKIRKQLS--------DPVAP-------------------LSAGLLTGRPLHSSPRL G_aculeatus_ENSGACP00000017889 ---------------------------SPVPSSH-----L--L-GPRLQSAPTLTEFYQ--TRQKLHKQLS--------DPVQPSSS---C--SHSPQLGRP-ASLGSSPTKLLGSSPRT M_musculus_ENSMUSP00000108029 ---------------------------SSVPE-HSPRTTG--L-GCRLHSAPNLSDFHV--VRPKLPKPPT--------DPLGATFS--------PPQTSAPQPCPGLQSCRPLRGSPKL H_sapiens_ENSP00000324560 ---------------------------SSAPE-HSPRTSG--L-GCRLHSAPNLSDLHV--VRPKLPKPPT--------DPLGAVFS--------PPQASPPQPSHGLQSCRNLRGSPKL R_norvegicus_ENSRNOP00000053633 ---------------------------SSVPE-HSPRTTG--L-GCRLHSAPNLSDFHV--VRPKLPKPPT--------DPLGATFS--------PPQTSAPQPCPGLQSCRPLRGSPKL O_anatinus_ENSOANP00000020106 ---------------------------SPVPPSQSPQSLL--L-GARL-----LTDIYQ--NKQKLRKQHS--------DPVCPSYAGYGY--SHTPQPSRP-VSLGTSPTKHTGSSPRS T_rubripes_ENSTRUP00000029855 ---------------------------GPSPDTQDASSIKVSLSAFRGERSVNITPSYFQTFSPQNNTSALNLLYF---QQVYPDRSSSAVDLQSL---AANQSNLGTISANKKGPFKRS O_latipes_ENSORLP00000017355 ---------------------------SVFPDVQVTTNPKF-LVHIDCLDLTLGIA-----SSRSLSSDTVTISFQHLDQPKKLNWTETVPDLQGLYKFPAFQTNIDHKSMHKKGPFKRS B_taurus_ENSBTAP00000017268 ---------------------------SSAPE-HSPHTSG--L-GYRLHSAPNLSDLHV--VRPKLPKPPT--------DPLGVAFG--------HPQASPPQPSHGLQSCRPLRGSPKL G_aculeatus_ENSGACP00000023344 ---------------------------PTAPQPHPQQAPG--L-GARLHSAPSLLECTGAAGKQKIRKQHS--------DPAVA-------------------PSAGLKTLRPLHSSPRL E_caballus_ENSECAP00000007293 ---------------------------SPVPQAQSPQPLL--L-GARLQSAPTLTDIYQ--NKQKLRKQHS--------DPVCPSHAGAGY--SYSPQPSRP-GSLGTSPTKHMGSSPRS M_domestica_ENSMODP00000031918 ---------------------------TSLPE-HSPR--G--L-GYRLHSAPNLSDLHV--VRPKLPKPPT--------EPLVAPFG--------YPQASPPQQHYGLQPCRTLRASPKL M_mulatta_ENSMMUP00000027852 ---------------------------SPVPQAQSPQSLL--L-GARLQSAPTLTDIYQ--NKQKLRKQHS--------DPVCPTHAGAGY--SYSPQPSRP-GSLGTSPTKHLGSSPRS A_carolinensis_ENSACAP00000000717 ---------------------------SPAPASHSPQSLV--MAGARLQNTPTLTDIYQ--NKQKLRKQHS--------DPVCPSYAAHGHPPPQPTQPPRP-VSLGTSPTKHPGSSPRG P_pygmaeus_ENSPPYP00000009920 ---------------------------SPVPQAQSPQSLL--S-GARLQSAPTLTDIYQ--NKQKLRKQHS--------DPVCPSHTGAGY--SYSPQPSRP-GSLGTSPTKHLGSSPRS C_familiaris_ENSCAFP00000026786 PLLVAADKSSQHTHHHYLLSPENTNDSSPVPQAQSPQPLL--L-GARLQSAPTLTDIYQ--NKQKLRKQHS--------DPVCPSHAGTGY--SYSPQPSRP-GSLGTSPTKHMGSSPRS C_familiaris_ENSCAFP00000009679 ---------------------------SSVPE-PSPHTAG--L-GYRLHSAPNLSDLHV--VRPKLPKPPT--------DPLGTAFG--------HPQSSPPQPAHGLQSCRPLRGSPKL E_caballus_ENSECAP00000014390 ---------------------------SSVPE-HSPHTAG--L-GCRLHSAPNLSDLHV--VRPKLPKPPT--------DPLGVVFG--------HPQASPPQPSHGLPSCRPLRGSPKL P_pygmaeus_ENSPPYP00000005848 ---------------------------SSAPE-HSTRTSG--L-GCRLHSAPNLSDLHI--VRPKLPKPPT--------DPLGAVFS--------PPQASPPQPSHGLQSCRNLRGSPKL T_guttata_ENSTGUP00000008305 ---------------------------SLVPE-QSPR--G--M-GSRLHSAPNLSDLHS--CRQKITKQHS--------DPLVAHFG--------HTPVSQPLQIHGLQHCRQLRSSPKL M_mulatta_ENSMMUP00000020714 ---------------------------SSVPE-HSTRTSG--L-GCRLHSAPNLSDLHV--VRPKLPKPPT--------DPLGAVFS--------PPQASPPQPSHGLQSCRNLRGSPKL P_troglodytes_ENSPTRP00000009595 ---------------------------SSAPE-HSTRTSG--L-GCRLHSAPNLSDLHV--VRPKLPKPPT--------DPLGAVFS--------PPQASPPQPSHGLQSCRSLRGSPKL S_cerevisiae_YGL180W ----------------------------------------------RLLRATSSSSGGSDGSR----------------RPSLVDRRLSISSLNPSN---ALSRALGIASTRLFGGANQQ P_pygmaeus_ENSPPYP00000014729 ---------------------------T-LLCNPDF----CQRIQSQLHEAGGQILKGILEGASHILPAFR--------VLSSLLSSCSDSVALYSF---CREAGLPGLLLSLLRHSQES M_mulatta_ENSMMUP00000008885 ---------------------------T-LLCNPDF----CQRIQSQLHEAGGQILKGILEGASHILPAFR--------VLSSLLSSCSDSVALYSF---CREAGLPGLPLSLLRHSQES P_troglodytes_ENSPTRP00000022091 ---------------------------T-LLCNPDF----CQRIQSQLHEAGGQILKGILEGASHILPAFR--------VLSSLLSSCSDSVALYSF---CREAGLPGLLLSLLRHSQES H_sapiens_ENSP00000295709 ---------------------------T-LLCNPDF----CQRIQSQLHEAGGQILKGILEGASHILPAFR--------VLSSLLSSCSDSVALYSF---CREAGLPGLLLSLLRHSQES O_cuniculus_ENSOCUP00000001738 ---------------------------T-LLCNPDF----CQHIQTQLHASGAQILKGSLEGASHILPALR--------VLSSLLSSCSDSAPLYSF---CREAGLPGLLLSLLRHSQES B_taurus_ENSBTAP00000038069 ---------------------------T-LLCNPDF----CQRIQSQLHEAGEQILKGALEGAPCILPALR--------VLSSLLSSCSDSVPLYSF---CREAGLPGLLLSLLKHSQES C_familiaris_ENSCAFP00000021994 ---------------------------T-LLCNPDF----CQRIQGQLHEAGGQILKDVPEDASHILPALR--------VLSSLLSSCSDSVPLYSF---CREAGLPGLLLSLLRHSQES G_gallus_ENSGALP00000018526 ---------------------------S-LLRDPAF----RHRVQARLAESAQQVLEGMLEGASHLRPVLR--------VVGNLLATRCDSELLNLF---CQELSLPLSLLHLAKQMLES R_norvegicus_ENSRNOP00000022839 ---------------------------T-LLCNPDF----CQHIQSQLRGTGEQILKGVLDGASHLLPALR--------ILSSLLSSCSDSVLLYSF---CQEVGLPELPLSLLRYSQES E_caballus_ENSECAP00000008449 ---------------------------T-LLCNPDF----CQRIQAQLHEAAGQILKGMLEGASQILPALR--------VLSSLLSSCSDSVPLYSF---CREAGLPGLLLSLLRHSQEN M_musculus_ENSMUSP00000084430 ---------------------------T-LLCNPDF----CQRIQSQLRGTGEQILKGVLDGVSHLLPVLR--------ILSSLLSSCNDSVLLYSF---CQEAGLPELPLSLLRYSQES M_domestica_ENSMODP00000019211 ---------------------------T-LLCNPDF----CQRVQNQLHGAGGQVLEGILDGASRLLPTLR--------VVKSLLTTCSDSALLYAF---CREAGLPGLLLNLLRHSQSS A_carolinensis_ENSACAP00000002909 ---------------------------S-LLGDPAF----VQRIRVRLKDSGQQVLEGMLEGASHLRPALH--------VISNLLGTCCDSDLLCSF---CNDIGLPQFLMQLVESILKS G_gorilla_ENSGGOP00000001881 ---------------------------X-XXXXXXX----XXXXXXXXXXXXXXILKGILEGASHILPAFR--------VLSSLLSSCSDSVALYSF---CREAGLPGLLLSLLRHSQES G_aculeatus_ENSGACP00000012128 -----------------------------TALRKSSTSSPSNMMETSIDEGIETEEPDTEDESPHLLSAHQ--------TARFGQRRHTLSEVSNQ----PGPSNQGKLFAIGHNPSMGS M_domestica_ENSMODP00000018106 -----------------------------IMVRKGCQSLPSNMMETSIDEGIET-EGESEEDPSHSFDAFQ--------STRCGQRRHTLAEVTNQLVMMPG---TGKVFSVNDHPSLGS C_intestinalis_ENSCINP00000014205 ----------------------------TLLSDAEF----RRKILEEIKVAKDKALGGKLSGASTFRSIIK--------VMTNLLATKCDADLLWRF---CQELEIPNQFLEMLDHIWKN D_rerio_ENSDARP00000081199 ----------------------------------------LQGLKIKLLQAKTQLLVRKGEETSSILLPLK--------VLRNIVQGCRIGD-VETV---GKELELPHLLFSLIEDVLNI T_rubripes_ENSTRUP00000036932 -----------------------------TVLRKSSTSSPSNMMETSIDEGIETEEPDAEEDPPHLLSAYQ--------TARFGQRRHTLSEVTNQ----PGPSNQGKFFTLGHNPSMGS D_rerio_ENSDARP00000011264 -------------------------------------------------------------------------------------------------------ADLNGYVKYAKRSSNRP D_melanogaster_FBpp0112008 ----------------------------------------VNAQHLSAHAGGG--------------------------VNGANTRRHTVGPGDVAH---EQALANPNVPPIDFKCPPQC D_melanogaster_FBpp0074373 ----------------------------VINSHTCFVSGNSNMILNHMNDNFD--FQASLRGGGVAAKPIV--------APTVRQSRSKDLEK-------RKLSQNLDNFSVRLGHSVDH 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0075677 GSLSETPPPHAPSTWQ--------------------VSPGHSQSPLR----------------------------------------------------------RSGNSSPVLP----- A_gambiae_AGAP011295-PA GSLSETPP--PPSCWT--------------------VSPGSHQSPLR----------------------------------------------------------RSGTSSPVM------ A_aegypti_AAEL003819-PA GSLSETPP--PPSCWT--------------------VSPASHHSPLR----------------------------------------------------------RSGTSSPVL------ C_elegans_Y60A3A.1.1 TQDMVAADQMLSNLDPTTTTTT--------------IPKSATTANIQGIPRGARD--------------------------------------------------RSVTSPPQPTIH--- D_rerio_ENSDARP00000083843 SDWLTKSP--LPTIIGSPTK-VTAPFK---------IPKTQASCNLMALADSPIPN-------KTLM----DGRELCAHHCTAYPSSRQPAP-EA--SKTSFG--RSVSAGRLSEPP-VR R_norvegicus_ENSRNOP00000003792 SDWFFKTP--LPTIIGSPTK-TTAPFK---------IPKTQASSNLLALVTRHGPAES--Q-SKDGN----DPRQ-CSHCLLVQGSERHRSE-QQ--SKAVFG--RSVSTGKLSEQQHVK P_troglodytes_ENSPTRP00000042372 SDWFFKTP--LPTIIGSPTK-TTAPFK---------IPKTQASSNLLALVTRHGPAEE--Q-SKDGN----EPRE-CAHCLLVQGSERQRAE-QQ--SKAVFG--RSVSTGKLSDQQ-GK B_taurus_ENSBTAP00000029699 SDWFFRTP--LPTIIGSPTK-TTAPFK---------IPKTQASSNLLTLATRHGPSEG--Q-LKDGN----NPRK-CTHCVLVQGGERQKSE-HQ--VKAAFG---SLKLEDCSSAS-IS M_musculus_ENSMUSP00000004920 SDWFFKTP--LPTIIGSPTK-TTAPFK---------IPKTQASSNLLALVTRHGPAES--Q-SKDGN----DPRE-CSHCLSVQGSERHRSEQQQ--SKAVFG--RSVSTGKLSEQQ-VK H_sapiens_ENSP00000354877 SDWFFKTP--LPTIIGSPTK-TTAPFK---------IPKTQASSNLLALVTRHGPAEE--Q-SKDGN----EPRE-CAHCLLVQGSERQRAE-QQ--SKAVFG--RSVSTGKLSDQQ-GK O_latipes_ENSORLP00000018791 SDWLQKSP--LPTIIGSPTKPMSAPFK---------IPKTQASCNLMALVDSPAST-------KMLL----EARGLCSHHSNPYLAGRPAAP-EC--SRT-FG--RSVSTGRLSEQP-IR T_nigroviridis_ENSTNIP00000017404 SEWLQKSP--LPTIIGSPTKTISAPFK---------IPKTQASCNLMALADSPMPT-------RTLA----DARDVCAHHCSPYHTGRPAAP-EG--SRT-FG--RSVSTGRLSEQP-IR T_nigroviridis_ENSTNIP00000008902 SELMQRSP--LPTILGSPSR-AVPPFE---------FPKPPSPPNLFTVLT-QGLVLGSPG-NRSNPVDPPGSQ--VNHYSHP------RRR-GD--QVQGFG--RSQSAGRLSDML-LK M_domestica_ENSMODP00000005348 SDWLFKTP--LPTIIGSPTK--VAPSK---------IPKTQASSNLLALVTRQGPTDV--Q-AKDVS----DPRE-FSHFLSAQGSEKQMAE-QH--GKAPFG--RSVSTGKLSDQQ-VK T_guttata_ENSTGUP00000007355 SDWLFKTP--LPTIIGSPTK-ATAPFK---------IPKTQASSNLLALANRQGLAETLLQ-PKDIT----DPRD-FTHFHSSQAADKQA-E-QH--SKTTFG--RSVSTGKLSDQQ-VK T_rubripes_ENSTRUP00000015470 SEWLQKSP--LPTIIGSPTKIISAPFK---------IPKTQASCNLMALADSPMPT-------RTLA----DARDVCAHHCSPYHTGRPAAP-EG--SRT-FG--RSVSTGRLSEQP-IR O_anatinus_ENSOANP00000021856 SEFMQRNP--LPTIVGSPTK-VMRPYSVIPMGLPAPVPARSCSHGQGPLLGYLQIVVTPTR-NRTLP----DLKE-MGHFQGQHPGLGFRPV-EE--IKGPFGRSRSLSTGRLTDLL-LK G_gallus_ENSGALP00000007513 SDWLFKTP--LPTIIGSPTK-ATTPFK---------IPKTQASSNLLALANRQGSIDAPLQ-PKDIT----EPRD-FSHFHSTQGSEKHAGE-QH--SKATFG--RSVSTGKLSDQQ-VK G_gallus_ENSGALP00000003776 SEFMQRSP--LPTIMGSPTK-AVSPFE---------FPKTSSSQNLLTLLAHQGVMMTPTR-NKTLP----DLKE-MGHFHCQQTGLGLRPV-EE--IKG-----RSLSTGRLTDLL-LK G_aculeatus_ENSGACP00000016289 E--------------------------------------------------------------------------------------------------------QSLSTGRLSDML-LK O_latipes_ENSORLP00000013892 SELMQRNP--LPTILGSPSK-AIPPFE---------FPKPPSSPNLMTLLTKQGMVIVPPC-SRTAPGELGDMQ--QAPSSGPRTAHCIHRL-SD--DNKRFG--RSQSAGGLSDML-LL G_aculeatus_ENSGACP00000017889 SDWLQKSP--LPTIIGSPTKTISAPFK---------IPKTQASCNLMALVDSPVPI-------KTLS----DARDICAHHCSPYLTGRPAAP-EA--SRT-FG--RSVSTGRLSEPP-IR M_musculus_ENSMUSP00000108029 PDFLQRSP--LPPILGSPTK-AGPSFD---------FPKTPSSQNLLTLLARQGVVMTPPR-NRTLP----DLSE-ASPFHGQQLGSGLRPA-ED--TRGPFG--RSFSTSRITDLL-LK H_sapiens_ENSP00000324560 PDFLQRNP--LPPILGSPTK-AVPSFD---------FPKTPSSQNLLALLARQGVVMTPPR-NRTLP----DLSE-VGPFHGQPLGPGLRPG-ED--PKGPFG--RSFSTSRLTDLL-LK R_norvegicus_ENSRNOP00000053633 PDFLQRSP--LPPILGSPTK-AGPSFD---------FPKAPSSQSLLTLLARQGVVMTPPR-NRTLP----DLSE-AGPFQGQQLGSGLRPA-ED--TRGPFG--RSFSTSRLTDLL-LK O_anatinus_ENSOANP00000020106 SDWLFKTP--LPTIIGSPTK-ATAPFK---------IPKTQGTSNLLALVTRQGPTDAPLP-SKGGA----DPRE-FSNFLTVQGSERPAAE-QQ--SKTTFG--RSVSTGRLSDQQ-MK T_rubripes_ENSTRUP00000029855 EQQELGIPVRLTVKVGERVP-VCGVYC---------VPFADLLTAVLKILVQPIETKK-------------NIRNWYLIIKYSFFPSSTESP-NEFSAPIIAG--LSLSTSRLSDMV-LK O_latipes_ENSORLP00000017355 EQVIKTIW----------------------------CLKAFLAVKHLA-----------------------KLVPWSPHFLMSVCHTKMHFE-MSDRTKALAF--RSLSTGRLSDML-LK B_taurus_ENSBTAP00000017268 PDFLQRNP--LPPILGSPTK-TVPVFE---------FTKTPSSQNLLTLLARQGVVMTPPR-NRTLP----DLSE-AGPFQGQQLGPGLRPT-ED--TKGAFG--RSLSTGRLTDLL-LK G_aculeatus_ENSGACP00000023344 SELMQRSP--LPTILGSPSR-AIPPFE---------FPKPPSSPNLVTFLTQQGLVIGSPC-SRTAPPEPRDVGQ-RALTQVIQPAHCIHRR-SD--DAKVFG--RSQSAGRLSDML-LM E_caballus_ENSECAP00000007293 SDWFFKTP--LPTIIGSPTK-TTAPFK---------IPKTQASSNLLALVTRHGPSEE--Q-SKDEN----DPRE-CSHCLLVQGSERQKPE-QQ--NKAVFG--RSVSTGKLSDQQ-VK M_domestica_ENSMODP00000031918 PDFMQRNP--LPPILGSPTK-AVPAFE---------FPKTPSSQNLLTLLAHQGVVVTPTR-NRTLP----DLRE-MGHFHSPP-SLGLRPV-EE--LKGPFG--RSLSTGRLTDLL-LK M_mulatta_ENSMMUP00000027852 SDWFFKTP--LPTIIGSPTK-TTAPFK---------IPKTQASSNLLALVTRHGPAEE--Q-SKDGN----EPRE-CAHCLLVQGSERQRAE-QQ--SKAVFG--RSVSTGKLSDQQ-GK A_carolinensis_ENSACAP00000000717 SDWLFKTP--LPTIIGSPTK-ATAPFK---------IPKTQASSNLVGLLARPGSAEAQLPPAKEAG----EMAREFPHFHSAQGAERQAQQ-QQHHGKALFG--RSVSTGKLSDQQ-AK P_pygmaeus_ENSPPYP00000009920 SDWFFKTP--LPTIIGSPTK-TTAPFK---------IPKTQASSNLLALVTRHGPAEE--Q-SKDGN----EPRE-CVHCLLVQGSERQRAE-QQ--SKAVFG--RS-STGK-SDHQ-GK C_familiaris_ENSCAFP00000026786 SDWFFKTP--LPTIIGSPTK-TTAPFK---------IPKTQASSNLLALVTRHGPTEG--Q-SKDGN----DPRE-CSHCLLVQGSERQKSE-QQ--NKAVFG--RSVSTGKLSDQQ-VK C_familiaris_ENSCAFP00000009679 PDFLQRNP--LPPILGSPTK-ALPAFD---------FPKNPSSQNLLTLLARQGVVMTPPR-NRTLP----DLSE-AGPFQGQQLGPGLRPT-ED---KSPFG--RSLSTGRLTDLL-LK E_caballus_ENSECAP00000014390 PDFLQRNP--LPPILGSPTK-AMPTFD---------FPKTPSSQNLLTLLARQGVVMTPPR-NRTLP----DLSE-AGPFQGQHLGPGLRPS-DD--TKGPFG--RSLSTGRLTDLL-LK P_pygmaeus_ENSPPYP00000005848 PDFLQRNP--LPPILGSPTK-AVPSFD---------FPKTPSSQNLLALLARQGVVMTPPR-NRTLP----DLSE-VGPFHGQPLGPGLRPG-ED--PKGPFG--RSFSTSRLTDLL-LK T_guttata_ENSTGUP00000008305 SEFMQRSP--LPTIVGSPTK-AVSPFE---------FPKTPSSQNLLTLLAHQGVMMTPTR-NKTLP----DLKE-MGHFHCQQTGLGLRPV-EE--IKGSIM--LSLSTGRLTDLL-LK M_mulatta_ENSMMUP00000020714 PDFLQRNP--LPPILGSPTK-AVPSFD---------FPKTPSSQNLLALLARQGMVMAPPR-NRTLP----DLSE-VGPFHGQPLGPGLRPG-ED--PKGPFG--RSFSTSRLTDLL-LK P_troglodytes_ENSPTRP00000009595 PDFLQRNP--LPPILGSPTK-AVPSFD---------FPKTPSSQNLLALLARQGVVMTPPR-NRTLP----DLSE-VGPFHGQPLGPGLRPG-ED--PKGPFG----------------- S_cerevisiae_YGL180W QQQQQI------------------------------TSSPPYSQTLLNSQLFHELTENIILRIDH----------------------------------------LQHPETLKLDNTNIV P_pygmaeus_ENSPPYP00000014729 NSLQQQSW--YGTFLQDLMA----------------VIQAYFACTFNLE---RSQTSDSLQVFQEAANLFLDLLGKLLA---QPDDSEQTLRRDSLMCFTVLCEAMD-GNSRAISKAFYS M_mulatta_ENSMMUP00000008885 NSLQQQSW--YGTFLRDLMA----------------VIQAYFACTFNLE---RSQTGDSLQVFQEAANLFLDLLGKLLA---QPDDSEQTLRRDSLMCFTVLCEAMD-GNSRAISKAFYS P_troglodytes_ENSPTRP00000022091 NSLQQQSW--YGTFLRDLMA----------------VIQAYFACTFNLE---RSQTNDSLQVFQEAANLFLDLLGKLLA---QPDDSEQTLRRDSLMCFTVLCEAMD-GNSRAISKAFYS H_sapiens_ENSP00000295709 NSLQQQSW--YGTFLQDLMA----------------VIQAYFACTFNLE---RSQTSDSLQVFQEAANLFLDLLGKLLA---QPDDSEQTLRRDSLMCFTVLCEAMD-GNSRAISKAFYS O_cuniculus_ENSOCUP00000001738 SSIQTQPW--YGAFVRDLMA----------------AMQAYFACTFNLD---RSQTGDXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXCFTVLCEAMD-GNSQAISKAFYS B_taurus_ENSBTAP00000038069 NSIQQQCW--YGAFVQDLVA----------------VIQAYFACTFNLE---RSQTGDSLQVFQEAASLFLDLLGKLLA---QPDDSEQALRRDILMCFTVLCEAMD-GNSWTVSKAFYS C_familiaris_ENSCAFP00000021994 NSIQQQCW--YGTFLRDLMA----------------VIQAYFACTFNLE---RSQTGDSLQVFQEAANLFLDQLGKLLA---QPDDSKQTLRRDSLMCFTVLCEAMD-GNSWTISKAFYS G_gallus_ENSGALP00000018526 GSTRQQPW--CITVLTDLIM----------------VTTVYFSSECNLE---KSG-QDSLQTIQESANHFLALLPDLLA---EPADSEMRLCQQSLLCFTLLCESLD-AMCPSISAPFYA R_norvegicus_ENSRNOP00000022839 SSIQQQPW--YGAFLRELVA----------------VVQAYFSCTFNLE---RSQTGDSLQVFEEAASLFLDLLGKLLA---QPDDSEPTFRRDSLMCFAVLCEAVD-GNSRAISKAFYA E_caballus_ENSECAP00000008449 NSIQQQCW--CGTFLQDLMA----------------VIQAYFACTFNLE---RSQTGDSLQVFQEAANHFLDLLGKLLA---QPDDSEQNLWRDSLMCFIVLCEAMD-GNSWTVAKAFYC M_musculus_ENSMUSP00000084430 SSIQQQPW--YGALLRDLVA----------------VVQAYFSCTFNLE---RSQTGDSLQVFQEAASLFLDLLGKLLA---QSDDSEQTFRRDSLMCFAVLCEAVD-GNSWAVSKAFYS M_domestica_ENSMODP00000019211 VNIQQQPW--CGTFLRDLVA----------------TIQAYFAGNFNLE---KSQTSDSLHVFQEAANLFLNLLGKLLA---QPDDAEQTLRRDSLMCFTDLCKTMD-GSNLAISKSFYC A_carolinensis_ENSACAP00000002909 FNIKQQPW--HITLLTDLMA----------------VMTVFFASDFNRE---KDGKKQSLQAFQSSANHFLTLLPALLA---QPTDQEGRLREQSLVCFTHLCQSMD-NACPSISIPFYT G_gorilla_ENSGGOP00000001881 NSLQQQSW--YGTFLQDLMA----------------VIQAYFACTFNLE---RSQTSDSLQVFQEAANLFLDLLGKLLA---QPDDSEQTLRRDSLMCFTVLCEAMD-GNSRAISKAFYS G_aculeatus_ENSGACP00000012128 MDSDMGYD----------------------------MGSMQSDLGLLDDPPSLGEVVAANSTAAGIAPAPFLSARPANPAMAVLTSQHRETHNRSP---------VSFREGRRASDTSLT M_domestica_ENSMODP00000018106 VDSE--YD----------------------------MGSIQRDLNFLEDNPSLKDIMLANQPTHRLTP-PFISIRPANPAMQVLSSQKRETHNRSP---------VSFREGRRASDTSLT C_intestinalis_ENSCINP00000014205 ETQKKRSW--SNKIMTDIVA----------------LLTTYVASDFNVQNVNNKQDVNTQREFGDSAVKIIRSLAKIIS---SKPTHNHTLHDQTLLCLIFICESVDHGQNIAVAAKVYK D_rerio_ENSDARP00000081199 PDLMQ------------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000036932 VDSDMGYD----------------------------MGSMHSDIGLLEDPPSLSELVSSSTSTQTVTPSPFLSARPPNPAMAALTSQHRETHNRSP---------ISFREGRRASDTSLT D_rerio_ENSDARP00000011264 GQNLQ------------------------------------------------------------------------------------------------------------------- D_melanogaster_FBpp0112008 SDPTQP------------------------------VPYYPVNLPMLQNQPLHNLTIKDQHLLKPPVVM------------------------------------GASSFGRRAS----- D_melanogaster_FBpp0074373 EAQRK-------------------------------------ATEIATQEKHNQENKPPAEAISYANSQPPQQQPQQLKHSMHSTNEEKLSSDNTPPCLLPGWDSCDESQSPPIENDEWL 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0075677 -----------------------------------------------------SAALTKLPTLGSPTMLVAPGSLG----SIGSAGSGS----ENNNQH-----------------HMLG A_gambiae_AGAP011295-PA -----------------------------------------------------NNALSKLPALGSPTTLM----------------GGV----ENNNHHHHHHHG-----------HPLT A_aegypti_AAEL003819-PA -----------------------------------------------------SNALSKLPALGSPTLLT------------------N----DNNNT------------------HPLG C_elegans_Y60A3A.1.1 --------------------ENEPLD---------------------------NAKYQQTDVNNSPTAPTEPFIIK----NQTTCSTSS----TSSSV-------------------VEE D_rerio_ENSDARP00000083843 ITLGG--QPY-QGSTDSLNTER-PMDT-------APAGMCALA------AGG-GSPRTVVFTVGSPPSSSTPPTCSHLASRPRATSVGS----NSSAGSLCSTSG---KVYMGSPP-GMT R_norvegicus_ENSRNOP00000003792 APLGG----H-QGSTDSLNTER-PMDV-------APAGACGVVLALPA-GTA-ASARAVLFTVGSPPHSATAPTCTHMVLRTRTTSVGS----NSSGGSLCSASG---RVCVGSPP-APG P_troglodytes_ENSPTRP00000042372 TPICR----H-QGSTDSLNTER-PMDI-------APAGACGGVLAPPA-GTA-ASSKAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGP----SNSGGSLCAMSG---RVCVGSPP-GPG B_taurus_ENSBTAP00000029699 TIK----QPD-QTSSCSMPVETISQKA-------APAGACGVALAPAI-GAA-ASSRAVMFTVGSPPHRAAATTCTHTGLRIRTTSGGS----SGSGGSLCSIGG---RVCGGSPP-GLC M_musculus_ENSMUSP00000004920 APLGG----H-QGSTDSLNTER-PMDV-------APAGACGVMLALPA-GTA-ASARAVLFTVGSPPHSATAPTCTHMVLRTRTTSVGS----SSSGGSLCSASG---RVCVGSPP-GPG H_sapiens_ENSP00000354877 TPICR----H-QGSTDSLNTER-PMDI-------APAGACGGVLAPPA-GTA-ASSKAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGP----SNSGGSLCAMSG---RVCVGSPP-GPG O_latipes_ENSORLP00000018791 ITLGG--QPS-EGSTDSLNTER-PMDTGTAAGRLSPCRPNMLLQ-----GGS-ASPRTVVFTVGSPPSSSTPPTCSHLGTRPRTTSVGS----NSSAGSLCSTSG---RLHVGSPP-GMA T_nigroviridis_ENSTNIP00000017404 ITLGG--QAY-QGSTDSLNTER-PMDTAPQ----APAGPGVQPQ-----GGS-ASPRTVLFTVGSPPKSSTPPR----STSTLLFSVGS----NSSAGSLCSTSG------------GFL T_nigroviridis_ENSTNIP00000008902 AAFGP-APSDTPTSCPNLQHFD-VL---------SPVAPPSGGTSP---TAGCSSPAGVVFTVGSPPSGSNPPLAS----RHRKSS-GS----FASISPAGSVSG---R--------PLQ M_domestica_ENSMODP00000005348 TPLGG--QLY-QGSTDSLNTER-PMDT-------APAGTCGIVLGPPG-VTG-ASSRAVMFTVGSPPNSATPPTCTQMVLRTRTTSVGS----NSSGGSLCSTSG---RIYMGSPP-GIY T_guttata_ENSTGUP00000007355 TTLGG--QLY-QGSTDSLNTER-PMDT-------APAGAYGIAMATPSMASGAASSRAVMFTVGSPPSSATPPTCTHMVLRTRTTSVGS----NSSGGSLCSTSG---RVYMGSPP-GIY T_rubripes_ENSTRUP00000015470 ITLGG--QAY-QGSTDSLNTER-PMDT-------APAGPSVQHQ-----CGS-ASPRTVLFTVGSPPKSSTPPTCSHLGTRPRTTSVGS----NSSAGSLCSTSG---RVQMC------- O_anatinus_ENSOANP00000021856 AAFGA--QVSEAGSNDSLNNEK-PMEIT------GPSAGYGGNLFSGARAGGSSSPSPVVFTVGSPPSGTTPPQAP----RTRMFSVGS----SGSPSSGTSFS----R--------HML G_gallus_ENSGALP00000007513 TTLGG--QLY-QGSTDSLNTER-PMDT-------APAGAYGIAVAPPSMGSG-ASSRAVMFTVGSPPSSATPPTCTHMVLRTRTTSVGS----NSSGGSLCSTSG---RVYMGSPP-GIY G_gallus_ENSGALP00000003776 AAFGA--QISEAGSNDSLNNEK-PMEIA------APSGAYGGTLHSGARAGGSASPSPVIFTVGSPPSGTTPPQTT----RTRMFSVGS----SSSLSSGGSFTG---R--------HLA G_aculeatus_ENSGACP00000016289 ATFGA--HLVGEDSDESLNSEK-SMDI-------TAPPTGRQRGFLYS-----DSPPPAIFTLGLQSRENTPPDTT----GPRIQSAGP----LVSAVDGSSVHV---LLLISGSPSRLL O_latipes_ENSORLP00000013892 AAFGAGGHAGDRGSTENLTAAK-AIEITEKALFPCPLGPPGGGF-----APGCSSAAQVVFTVGSPPSGSTPPLTS----RQRKCSGSS----FTSVSPACSFSA---R----------H G_aculeatus_ENSGACP00000017889 ISLGG--QAY-QGSTDSLNTER-PMDT-------APAGPCGLIH-----GGS-GSPRTVLFTVGSPPSSSTPPTCSHLGTRPRTTSVGS----NSSAGSLCSTSG---RVYVGSPP-GMA M_musculus_ENSMUSP00000108029 AAFGT--QASDSGSTDSL-QEK-PMEI-------APSAGFGGTLHPGARGGGASSPAPVVFTVGSPPSGATPPQST----RTRMFSVGS----SSSLGSTGSSSA---R--------HLV H_sapiens_ENSP00000324560 AAFGT--QAPDPGSTESL-QEK-PMEI-------APSAGFGGSLHPGARAGGTSSPSPVVFTVGSPPSGSTPPQGP----RTRMFSAGP----TGS----ASSSA---R--------HLV R_norvegicus_ENSRNOP00000053633 AAFGT--QASDSGSTDSL-QEK-PMEI-------APSAGFGGTLHPGARAGGASSPAPVVFTVGSPPSGTTPPQST----RTRMFSVGS----SSSLGSTGSSSA---R--------HLV O_anatinus_ENSOANP00000020106 TPLGG--QLY-QGSTESLNAER-PMDI-------APAGPCGVILAQPA-ATG-ASSRAVMFTVGSPPSSATPPTCTHMVLRTRTTSVGS----NSSGGSLCSTSG---RVFMGSPP-GLY T_rubripes_ENSTRUP00000029855 GAFGA--QLLENRSDGSFNCEK-SLDV-------HLAHSSKWVLHPEEPVLRDSFSQKILFLNGMRTYLTMFSGC-----NHYLPSLLT----LLIVFSHHFTFS---LLIRVIGEGYIP O_latipes_ENSORLP00000017355 AAFGA--NLFEEESDESFGTDK-SMDP-------TGMRSGSGKHFAFTVSLSEDSPPPVVFTMGSPSQGTTPPDAK----VSRMFSGGC----LRFGNSGSPSHINSAWLLNSRTP---- B_taurus_ENSBTAP00000017268 AAFGT--QAPDSGSTDSL-QEK-PMEI-------APSAGFGGNLHPGARAGGASSPSPVVFTVGSPPSGTTPPQGP----RTTMFSVGS----SSSLSSAGSSSA---R--------HLA G_aculeatus_ENSGACP00000023344 AAFGPGGPVGDRDSAENLTSEK-TIDI---------MVPPGGGGSP---APGSISPAQVVFTVGSPPSASSPPHTS----RQRKYSVNP------TMSSSGSFTS---R--------YPQ E_caballus_ENSECAP00000007293 TPLGG----H-QGSTDSLNTER-PMDI-------APAGACGVVLSPPV-GTA-ASSRAVLFTVGSPPHSATAPTCTHMVLRTRTTSVGS----SSSGGSLCSASG---RVCVGSPP-GPC M_domestica_ENSMODP00000031918 AAFGS--QAPDTGSNESL-QEK-PMEI-------APSAGYGGNLLPGARTGGSSSPSPVIFTVGSPPSGTTPPQVP----RTRMFSVGS----SSSQSSGGSFSG---R--------HLI M_mulatta_ENSMMUP00000027852 TPIGG----H-QGSTDSLNTER-PMDI-------APAGACGIVLAPPA-GIA-ASSRAVLFTVGSPPHSAVAPTCTHMLLRARTTSVGP----SNSGGSLCAVSG---RVCVGSPP-GPG A_carolinensis_ENSACAP00000000717 AALGG--QLY-QGSTDSLNTER-PMDT-------APPAACVLAAPPPCLGTG-AGSRAVMFTVGSPPNSATPPTCAHMLLRARTTSVGS----NSSGGSLCSTSG---RVLVGSPP-GIY P_pygmaeus_ENSPPYP00000009920 TPICR----H-QGSTDSLNTER-PMDI-------APAGACGGVLAPPA-GTA-ASSRAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGP----SNSGGSLCAMSG---RVCVGSPP-GPG C_familiaris_ENSCAFP00000026786 IPLGG----H-QGSTDSLNTER-PMDIV------APAGACGGVLAPPI-GTA-ASSRAVLFTVGSPPHSATAPTCTHMVLRTRTTSAGS----SSSGGSVCSASG---RVCVGSPPLGPC C_familiaris_ENSCAFP00000009679 AAFGT--QAPDSGSTDSL-QEK-PMDI-------APSAGLGGNLHPGARAGGASSPSPVVFTVGSPPSGTTPPQGP----RTRMFSVGS----SSSLGSVGSSSA---R--------HLA E_caballus_ENSECAP00000014390 AAFGT--QAPDSGSTDSL-QEK-PMEI-------APSAGLGGNLHPGARAGGASSPAPVVFTVGSPPSGSTPPQGP----RARMFSVGS----SSSLSSAGSSSA---R--------HLA P_pygmaeus_ENSPPYP00000005848 AAFGT--QAPDPGSTESL-QEK-PMEI-------APSAGFGGSLHPGARAGGASSPSPVVFTVGSPPSGSTPPQGP----HTRMFSVGS----TGS----AGSSA---R--------HLV T_guttata_ENSTGUP00000008305 AAFGA--QISEAGSSDSLNNEK-PMEIA------APSGAFGGTLHSGARA-GSASPSPVIFTVGSPPSGTTPPQTA----RTRMFSVGS----SSSLSSGGSFSG---R--------HLA M_mulatta_ENSMMUP00000020714 AAFGT--QAPEPGSTESL-QEK-PMEI-------APSAGCGGSLHPGARAGGASSPSPVVFTVGSPPSGSTPPQGP----RTRMFSVGS----TGS----AGSSA---R--------HLV P_troglodytes_ENSPTRP00000009595 ---------------------------------------------------------------------------------------GP----TGS----ASSSA---R--------HLV S_cerevisiae_YGL180W SILESL-----------------------------------------------AAKAFVVYSYAEVKFSQIVPLST-------------------------------------------- P_pygmaeus_ENSPPYP00000014729 SLLTTKQVVLDGLLHGLTVPQL-PVHT-------PPGAPQVSQPLREQSEDIPGAISSALAAICTAPVGLPDCWDGKE--QVCWHLANQ----LTEDSSQLRPSLVSGLQHPILCLHLLK M_mulatta_ENSMMUP00000008885 SLLTTQQVVLDGLLHGLTVPQL-PVHT-------PPGAPQVSQPLREQSEDLPGAISSALAAICTAPVGLPDCWDAKE--QVCWHLANQ----LTEDSSQLRPSLISGLQHPILCLHLLK P_troglodytes_ENSPTRP00000022091 SLLTTQQVVLDGLLHGLTVPQL-PVHT-------PPGAPQVSQPLREQSEDIPGAISSALAAICTAPVGLPDCWDAKE--QVCWHLANQ----LTEDSSQLRPSLISGLQHPILCLHLLK H_sapiens_ENSP00000295709 SLLTTQQVVLDGLLHGLTVPQL-PVHT-------PQGAPQVSQPLREQSEDIPGAISSALAAICTAPVGLPDCWDAKE--QVCWHLANQ----LTEDSSQLRPSLISGLQHPILCLHLLK O_cuniculus_ENSOCUP00000001738 SLLTTQRVVLDGLLHGLTMPQL-PFHT-------PPGAPQASQPLRDLSEDLPGAVSSALAAVCTAPVGLPSCWEAKE--QVSWHLATQ----LIEDSSQLRPSLVSGLQHPILCLSLLK B_taurus_ENSBTAP00000038069 SLLTTHRAVLDGLLYGLTAPQL-PFHS-------PPGAPQVSQPLREQSEDLPGAISSVLAAMCTAPVGLPGCWEAKE--QIAQHLADQ----LTKDSNHLRSSLISALQHPILCLPLLK C_familiaris_ENSCAFP00000021994 SLLTTQRAVLDGLLHGLTVPQL-SFHT-------PPGAPQVSQPLREQSEDLPGAMSSALAAICTAPVGLPSCWEAKE--QISRHLANQ----LSEDSNQLRPSLISGLQHPILCLHLLK G_gallus_ENSGALP00000018526 SLREENEPLLDRLLQGLISEQP-ALQG-------LPGATMEAKSAHDQRQCVADLCTAALAAACSIPLAQSSCRETKQ--QVAQEIAGK----LMDGECQQLGKLLGRLEHPNCSLNVLK R_norvegicus_ENSRNOP00000022839 SLLTTQRAVLDGLLHGLTVPQL-PFHT-------PPGAPQVSQPLREQSEDVPGAISSALAAMCTAPVGLPSCWDAKE--QVSWHLANQ----LTEDSSQLRPSLISGLRHHILCLHLLK E_caballus_ENSECAP00000008449 SLLTTQRAVLDGLLHGLTVLQL-PVHS-------PPGAPQVSQPLREQSADLPGALSSALAAICTTPVGLPGCWKAKE--QITRHLANQ----LIEDSTQLRPSIISGLKHPILCLHLLK M_musculus_ENSMUSP00000084430 SLLTTQRAVLDGLLHGLTVPQL-PFHT-------PPGAPQVSQPLREQSEDVPGAISSALAAMCTAPVGLPSCWDAKE--QVSWHLANQ----LTEDSSQLRPSLISGLRHHVLCLHLLK M_domestica_ENSMODP00000019211 SFLTTHKPVLDGLLHGMALPQL-PLHT-------PPGAPQVSQPLREQDEDLPRAFATALAAICTLPVGLPGCWEAKE--QVSKHLADQ----LTDDSSQLRPYLFSSLQHPSLSLHLLK A_carolinensis_ENSACAP00000002909 SLLENHCPLLDTLCHGVSCEQI-IQEV-------PPKEARSKQ---HWNELMGAAFAKALAASCVIPGRHTVCQKAKK--KISQYIAEK----LTEKENRLLASLILAVNHPASSLHGLK G_gorilla_ENSGGOP00000001881 SLLTTQQVVLDGLLHGLTVPQL-PVHT-------PPGAPQVSQPLREQSEDIPGAISSALAAICTAPVGLPDCWDAKE--QVCWHLANQ----LTEDSSQLRPSLISGLQHPILCLHLLK G_aculeatus_ENSGACP00000012128 QGLVAFRQHLQNLARTKGILEL-------------------------------NKVQMLVEQMGSGEGASMGPLGPQQHLHNLLESASSHRVAQKQQQEGLALYQGGPHPPLLSRRQSLE M_domestica_ENSMODP00000018106 QGLVAFRQHLQNLARTKGILEL-------------------------------NKVQLLYEQMGSEAEPSLASAAPQ--LQDLVSSASQEE--ATQQQENASAFPNTVHPQ-LSRRQSLE C_intestinalis_ENSCINP00000014205 ELSNC--GLVEVIFKHALNKDL------------WVKDLVKDSDLEKRTDEIQALYLSCLAAVAYIPVIGLPIRQFKN--IVTENIAKL----ITNNSALLSTVS-ILLSHPAMCLNCLK D_rerio_ENSDARP00000081199 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000036932 QGLVAFRQHLQNLARTKGILEL-------------------------------NKVQMLVEHMGSREGTAMSPVGPQHHLHNLLELKGE----ASKQQEGLTLYQGGPHPPLLSRRQSLE D_rerio_ENSDARP00000011264 -----------------------------------------------------TGVCSVM------------------------------------------------------------ D_melanogaster_FBpp0112008 -----------------------------------------------------DGGANLHIYYPATGTVVGPAQ------GQQMDTAGY----YINPNCGTDPLA-------VQELSPLN D_melanogaster_FBpp0074373 AFLNR------------------------------------------SVQELLDGELDSLKQHNLVSIIVAPLRNSKAIPRVLKSVAQL----LSLPFVLVDPVL-------IVDLELIR 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0075677 PRAFT-----------L--PELGATGGLHSLLDTGAGGGGEPHAFQAPELSEETLMD--REHNETLSKLNFV--LALTDCIQEVADSRCAPLSTFMVAGSQSAAQAASADAQQIPPHAPE A_gambiae_AGAP011295-PA ARAFT-----------L--PELGAAGGLQSYLDDHTID-DHPINFHAPELHAETLLD--RDHNETLAKLNFV--VALTDCILDVADSRCAPLSSMM-----------LADAQPVPPHQPE A_aegypti_AAEL003819-PA SRAFT-----------L--PEMGPTAGLGSYLHDTNMD-DHPINFHAPELPAETLMD--REHNETVAKLNFV--IALTDCILEVANSRCEPLSALM-----------SADAQPIAPHAPE C_elegans_Y60A3A.1.1 EEAMS--------------LPFASGSHLAAGFKKTPAEVPMDHGALPPALDQEIVLG--EEHKQILAKLRFV--AELVDTLIHVAEQKDNPL------ASAMASRRQLLTTGTSTTNTSS D_rerio_ENSDARP00000083843 IGSSP----------PG--AEAGPSSLRYVPYGTSPPSLDGFITFEAPELPEETLME--REHTDTLMYLRMM--LSFTDCVLEIAALRAGGP--DLGASAASLYPPQDSVVVDQISQLSR R_norvegicus_ENSRNOP00000003792 FGSSP----------PG--AEAAP-SLRYVPYGASPPSLEGLITFEAPELPEETLME--REHTDTLRHLNMM--LMFTECVLDLTAVRGGNP--ELCTSAVSLYQIQESVVVDQISQLSK P_troglodytes_ENSPTRP00000042372 FGSSP----------PG--AEAAP-SLRYVPYGASPPSLEGLITFEAPELPEETLME--REHTDTLRHLNVM--LMFTECVLDLTAMRGGNP--ELCTSAVSLYQIQESVVVDQISQLSK B_taurus_ENSBTAP00000029699 SGSPP----------PG--AEAAP-SLRHVPCGASPPSLEGLVTFEAPELPEETLME--QEHADTLRHLNSM--LLFTECVLDLTAVRGGSP--ELCASAVSVYQIQESAVVDQISQLSK M_musculus_ENSMUSP00000004920 LGSSP----------PG--AEGAP-SLRYVPYGASPPSLEGLITFEAPELPEETLME--REHTDTLRHLNMM--LMFTECVLDLTAVRGGNP--ELCTSAVSLYQIQESVVVDQISQLSK H_sapiens_ENSP00000354877 FGSSP----------PG--AEAAP-SLRYVPYGASPPSLEGLITFEAPELPEETLME--REHTDTLRHLNVM--LMFTECVLDLTAMRGGNP--ELCTSAVSLYQIQESVVVDQISQLSK O_latipes_ENSORLP00000018791 IGTSP----------PG--SFD----------GTSPPSLEGFITFEAPELPEETLME--REHTDTLMYLRMM--LSFTDCILEMAALRAGGP--DLGISVASLYPPQDSVVVDQISQLSK T_nigroviridis_ENSTNIP00000017404 GGQMM----------PG--VDGAPSSLRYVPYGTSPPSLEGFITFEAPELPEETLME--REHTDTLMHLRMM--LSFTDCVLEMAAVRAGGT--ELGVSAASLYPPQESVVVDQISQLSK T_nigroviridis_ENSTNIP00000008902 VG-----------------CDAPS-SPRYSCSDPFAPNMGVGVMFEAPELPEETLME--QEHTDTVHSLRFM--LDFAHCLVEVAGARGAGV--PEQDAPQASRVQQQSLVADQISSLSR M_domestica_ENSMODP00000005348 MGSSP----------PG--AEAAP-SLKYTPYGTSPPSLEGFITFEAPELPEETLME--REHTDTLRHLNTM--LTFTECVLDLTAIRGGNP--ELCTSAVSLYQIQESVVVDQISQLSK T_guttata_ENSTGUP00000007355 MGSSP----------PG--AEAAP-SLKYIPYGTSPPSLEGFITFEAPELPEETLME--REHTDTLRHLNMM--LTFTECVLDLTAVRGGNP--DLCTSAVSLYQIQESIVVDQISQLSK T_rubripes_ENSTRUP00000015470 ---------------PG--VEGAPSSLRYVPYGTSPPSLEGFITFEAPELPEETLMEEQREHTDTLMHLRMM--LSFTDCVLEMAAVRAGGT--ELGVSAASLYPPQDSVVVDQISQLSK O_anatinus_ENSOANP00000021856 LGTGA----------EA--PEAPS-SLRCTFTDPITANLEGAVTFEAPELPEETLME--QEHTDILRSLRFT--LAFVHSVMEIAAVKGSAG--ELGSSVASEYQLQESVVADQISLLSR G_gallus_ENSGALP00000007513 MGSSP----------PG--AEAAP-SLKYMPYGTSPPSLEGFITFEAPELPEETLME--REHTDTLRHLNMM--LTFTECVLDLTALRGGNP--DLCTSAVSLYQIQESIVVDQISQLSK G_gallus_ENSGALP00000003776 VGTGG----------DA--LEGPS-SLRYAFADPITANLEGAVTFEAPELPEETLME--QEHTDILRSLRFT--LAFVHYVMEIAALKGSSS--EMSGSVASEYQLQESVVADQISLLSR G_aculeatus_ENSGACP00000016289 QGG----------------------SRRNSESEAMDSTQHSSLVFHPPDLPEETLME--QAHTDELNELRFT--LAFVLCVTELASSKCSMP--EAVSSP-DVSFLEQSLVTDQISLLSR O_latipes_ENSORLP00000013892 TGTYA----------DG--FEAPP-SPRYNFADTVTANMGGPVTFEAPELPEETLME--QEHTDMVQRLRFT--LEFTHCLMEVAGARGVAA-GPLGDLSHLSLLQQQSLVADQISSLSR G_aculeatus_ENSGACP00000017889 LGTSPPGGFGGGQVMPG--SEGAPSSLRYVPYGTSPPSLEGFITFEAPELPEETLME--REHTDTLMHLRMM--LSFTDCVLEMAAVRAGET--QVGVSAAPLYPPQDSVVVDQISQLSK M_musculus_ENSMUSP00000108029 PGACG----------EA--PELSAPGHCCSLADPLAANLEGAVTFEAPDLPEETLME--QEHTETLHSLRFT--LAFAQQVLEIAALKGSAS--EAAG--GPEYQLQESVVADQISQLSR H_sapiens_ENSP00000324560 PGPCS----------EAPAPELPAPGHGCSFADPITANLEGAVTFEAPDLPEETLME--QEHTEILRGLRFT--LLFVQHVLEIAALKGSAS--EAAG--GPEYQLQESVVADQISLLSR R_norvegicus_ENSRNOP00000053633 PGACA----------EA--PELSAPGYCCSLADPLAANLEGAVTFEAPDLPEETLME--QEHTETLHSLRFT--LAFAQQVLEIAALKGSAS--EAAG--GPEYQLQESVVADQISQLSR O_anatinus_ENSOANP00000020106 MGSSP----------PG--AEAAP-SLKYTPYGNSPPSLEGFITFEAPELPEETLME--REHTDTLRHLNMM--LTFTECVLDLTAIRGGNP--ELCTSAVSLYQIQESVVVDQISQLSK T_rubripes_ENSTRUP00000029855 QNSFS---------------NYIPLSQRLGDSESMAATPNSGLFFHPPELPVDTLME--QAHTDTLTDLHFT--LAFAHCVMELASSKEPKL---GAASPADVSSPEQSLVTDQISQLSK O_latipes_ENSORLP00000017355 ----------------------PRGARRNSETDAMDTILHRNSLFHLPGLPEDTLME--EAHLDALSDLRFT--LAFVHCIMELASSKDPEL--EACSS--DISFLQKSLVTDQISLLSK B_taurus_ENSBTAP00000017268 PGAYS----------EA-TLEVPAPGHCCSFADPVTANLEGAVTFEAPDLPEETLME--QEHTEILHSLRFT--LVFVQHILEIAALKGSAS--EAAG--GPEDQLQESVVADQISLLSR G_aculeatus_ENSGACP00000023344 TCTYL----------DG--FEAPS-SPRYGFTDPITANMGGRVTFEPPELPEETLME--QEHTDIVQSLRFT--LDFARCLMEVAGACGVAALREQEDVSHPCLLQQQSVVADQISSLSR E_caballus_ENSECAP00000007293 PGSSP----------PG--AEIAP-SLRYMPYGASPPSLEGLITFEAPELPEETLME--REHTDTLRHLNVM--LMFTECVLDLTAVRGGNP--ELCTSAVSLYQIQESVVVDQISQLSK M_domestica_ENSMODP00000031918 PGMGG----------EA--SEAPGNLRCYGFTDPITANLEGAVTFEAPDLPEETLME--QEHTDILRSLRFT--LAFVHCVMEMAAAKGSSG--EMSSSVASEYHLQESIVADQISLLSR M_mulatta_ENSMMUP00000027852 FGSSP----------PG--AEAAP-SLRYVPYGASPPSLEGLITFEAPELPEETLME--REHTDTLRHLNVM--LMFTECVLDLTAVRGGNP--ELCTSAVSLYQIQESVVVDQISQLSK A_carolinensis_ENSACAP00000000717 SGSSP----------PG--AEAAP-CLKYMSYGTSPPSLEGFITFEAPELPEETLME--VRNKTQKHYLSTL--EEWMVKVFKIFQSRGATA--EKALSLVPTNRDCEVSFLSLPPSLCK P_pygmaeus_ENSPPYP00000009920 FGSSP----------PG--AEAAP-SLRKVPYGASPPSLEGLITFEAPELP-DTLME--REHTDTLRYLNVM--LMFTECVLD-TAMRGGNL--ELCTSAVSLYQIQESVVVDQISQLSK C_familiaris_ENSCAFP00000026786 LGSSP----------PG--AEAAP-GLRYMPHGASPPSLEGLITFEAPELPEETLME--REHTDTLRHLNVM--LTFTECVLDLTAVRGGHP--ELCTSAVSLYQIQESVVVDQISQLSK C_familiaris_ENSCAFP00000009679 PGACS----------EA-APEVPAPSHCCSFADPVTANLEGAVTFEAPDLPEETLME--QEHTEILHSLRFT--LVFVQHVLDIAALRGSAS--NTAG--GPEYQLQESVVADQISLLSR E_caballus_ENSECAP00000014390 PGACS----------EA-VPEV--PGHCCTFADPVAANLEGAVTFEAPDLPEETLME--QEHTEILHSLRFT--LVFVQHVLEIAALKGSAS--EAAG--GPEYQLQESVVADQISMLSR P_pygmaeus_ENSPPYP00000005848 PGACS----------EAPAPELPAPGHGCSFADPIAVNLEGAVTFEAPDLPEETLME--------------------------------------------------------------- T_guttata_ENSTGUP00000008305 VGAAG----------EA--LEGPS-SLRYTFADPITANLEGVVTFEAPELPEETLME--QEHTDILRSLRFT--LAFLHYMMQSAALKGSYS--DMRGG-PIKYSADASVVADQIS-LSR M_mulatta_ENSMMUP00000020714 SGACS----------EAPAPELPAPGHSCSFADPIAANLEGAVTFEAPDLPEETLME--QEHTEILRGLRFT--LLFVQHVLEIAALKGSAS--EAAG--GPEYQLQESVVADQISLLSR P_troglodytes_ENSPTRP00000009595 PGPCS----------EAPAPELPAPGHGCSFADPIAANLEGAVTFEAPDLPEETLME--------------------------IAALKGSAS--EAAG--GPEYQLQESVVADQISLLSR S_cerevisiae_YGL180W -------------------------------TLKGMANFENRRSMDSNAIAEEQDSDDAEEEDETLKKYKED-------CLSTKTFGKGRTL----------SATSQLSATFNKLPRSEM P_pygmaeus_ENSPPYP00000014729 VLYSC-----------C--LVSERL---CRLLGQEPLALESLFMLVQGKVKVVD--W--EESTEVTLYFLSL--LVFRLQNLPCG---MEKLGSDVATLFTHSHVVSLVSAAACLLGQLG M_mulatta_ENSMMUP00000008885 VLYSC-----------C--LVSERL---CRLLGQEPLALESLFVLVQGKVKVVD--W--EESTEVTLYFLSL--LVFRLQNLPCG---MEKLGSDVATLFTHSHVVSLVSAAACLLGQLG P_troglodytes_ENSPTRP00000022091 VLYSC-----------C--LVSEGL---CRLLGQEPLALESLFMLIQGKVKVVD--W--EESTEVTLYFLSL--LVFRLQNLPCG---MEKLGSDVATLFTHSHVVSLVSAAACLLGQLG H_sapiens_ENSP00000295709 VLYSC-----------C--LVSEGL---CRLLGQEPLALESLFMLIQGKVKVVD--W--EESTEVTLYFLSL--LVFRLQNLPCG---MEKLGSDVATLFTHSHVVSLVSAAACLLGQLG O_cuniculus_ENSOCUP00000001738 VLYSC-----------C--HVSERL---CRLLGQEPLALESLSLVVQGKVKAAD--Q--EESTEVALYLLAL--LVFRLQDLPCG---MEKLGGEVATLFTHSHVVSVVSAAACLLGQLG B_taurus_ENSBTAP00000038069 VLYSC-----------C--HVSERL---CHLLGQEPLALESLLNLAQGKVKVVD--R--EESTEVTLYLLSL--LVLRLQDLPCG---MEKLGSEIATVFTHSHVVSLVSAAACLLGQLG C_familiaris_ENSCAFP00000021994 VLYSC-----------C--HISERL---CHLLGQEPLALESLLMLVQGKVKVVD--W--EESTEVALYLLSL--LVLQLQDLPPG---MEKLGNEIATLFTHSHIVSLVSAAACLLGQLG G_gallus_ENSGALP00000018526 ILYTC-----------C--YASPSL---CQHLGRSQQVWDFLMQLSKGKVPMAEVTR--KVACEASLYLLAL--LTLQPQASPSR---LEEVVTLALDVLTQSPVISVVGAAAFLLTQLD R_norvegicus_ENSRNOP00000022839 VLYSC-----------C--YISERL---CHILGQEPLALESLLMLVQGKVKVAD--W--EESTEVALYLLSL--LVFRLQDLPSG---MEKLGSEVATLFTHSHIVSLVNAAACLLGQLG E_caballus_ENSECAP00000008449 ILYSC-----------C--HISEHL---CHLLVQEPLALESLLMLVRGKVKVVD--W--EESAEVTLYLLSL--LVLRLQDLPSG---MEKLGGEIATVFTRSHVVSLVSAAACLLGQLG M_musculus_ENSMUSP00000084430 VLYAC-----------C--YISERL---CHILGQEPLALESLLMLVQGKVKVAD--W--EESTEVALYLLSL--LVFRLQDLPSG---MEKLGSEVATLFTHSHVVSLVNAAACLLGQLG M_domestica_ENSMODP00000019211 VLYAC-----------C--HVNENL---CRRLDQEPLALESLLLLVQGKVDVID--P--EETAEATLHLLSL--LVLRLQVLPPG---VKKIGNELAVLFVHSPVVSLVSAAAGLLSQLS A_carolinensis_ENSACAP00000002909 VLYAC-----------G--HVSQTL---CHHLA-TPEMLNSLICHLQGKVFIHS--Y--LCYKENCLVLFSL--LMLQLQFLPSQ----TYLIRNLGTACTHSIPNRRVSAAALLLTYFI G_gorilla_ENSGGOP00000001881 VLYSC-----------C--LVSEHL---CRLLGQEPLALESLFMLIQGKVKVVD--W--EESTEVTLYFLSL--LVFRLQNLPCG---MEKLGSDVATLFTHSHVVSLVSAAACLLGQLG G_aculeatus_ENSGACP00000012128 TQYLT-------------------HRLQKANVLANSPASCQLFCKDT-RSLEQQLQEQRLNQKRMYLQQTQGMGLQVYFNQMQIAEGSYTTGGAALDPAASQGSPHGPPMSAAHQPQQQG M_domestica_ENSMODP00000018106 TQYLQ-------------------HRLQKPNLLSKAQNTCQLYCKESPRSLEQQLQEHRLHQKRLFLQKQSQ--LQAYFNQMQIAESSYPRPNQQL-PLP-----HQ---------EQLS C_intestinalis_ENSCINP00000014205 FIYAC-----------A--QLNPDV---CKVLCNESVA-TTLLHILSGSTPTHES----MEIQVIDLVLNIF--TSFTVSASESSKLLLQSSAALLGTVFVQSQQPTHVLSAAGLVYELS D_rerio_ENSDARP00000081199 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000036932 TQYLT-------------------HRLQQANVLANSPASCQLFCKEAPRSLEQQLQEHRLNQKRMYLQQSQGMGLQAHFNQMQIAEGSYPAGSSPLEPAT-----HQPP------AQQQT D_rerio_ENSDARP00000011264 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0112008 EQSVA-----------------------------------------QMQCCQENATGECNEELQSYMQKRGGTQRHTVGCTEDLSVAHGSGAGSQSQAPTTSSNMRQRRTGLLTVTERPP D_melanogaster_FBpp0074373 NVYVD-----------V--KLVPNLMYACKLL-------------LSHKQLSDSAASAPLTTGSLSRTLRSI--PELTVEELETACSLYELV---CHLVHLQQQFLTQFCDAVAI----- 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0075677 HCKRAERLVLLVRGLQLLSSGMNLASQQLSNGQLKPS--SN--------------------VKN-ALLTMNAKYRSMLFESKRLN----------------GSGLL-QKANAFNITADKI A_gambiae_AGAP011295-PA HCKRAERLVLLVRALHLLSAGMNLASAQIRAGNLKPS--NS--------------------VKN-VLTTMHAKYRSTLIESKKLN----------------SAGLL-QRANASNITADKI A_aegypti_AAEL003819-PA HCKRAERLVLLVRALNLLSSGMHLASSNLQSGQLKPS--DT--------------------VKN-VLSMMHTRYRSTLCESKKLN----------------GAGLL-QRAGASNITADKI C_elegans_Y60A3A.1.1 PYRRAEQLVVYVRALHMLSSALLLAQTNVANRVLHPS--VA--------------------VQQ-VLNQLNDKYHQCLVRSQELA----------------SLGLPGQDPAMAVISAERI D_rerio_ENSDARP00000083843 EWGQVEQLVLYMKAAQLLASSLHLAKAQIKSAKLNPS--TA--------------------VKQ-VVKSLNERYKSCISLCRRLTDKLNH-------FFSDKQRFV---DEINSVTAEKL R_norvegicus_ENSRNOP00000003792 DWGRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPS--TA--------------------VKQ-VVKNLNERYKFCITMCKKLTEKLNR-------FFSDKQRFI---DEINSVTAEKL P_troglodytes_ENSPTRP00000042372 DWGRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPS--TA--------------------VKQ-VVKNLNERYKFCITMCKKLTEKLNR-------FFSDKQRFI---DEINSVTAEKL B_taurus_ENSBTAP00000029699 DWGRVEQLVLYMKAAQLLAASLHLAKEQIKSGKLSPS--SG--------------------VKQ-VVKNLNERYKFCISMCKKLTEKLNR-------FFSDKQRFI---DEINSVTAEKL M_musculus_ENSMUSP00000004920 DWGRVEQLVLYMKAAQLLAASLHLAKAQVKSGKLSPS--MA--------------------VKQ-VVKNLNERYKFCITMCKKLTEKLNR-------FFSDKQRFI---DEINSVTAEKL H_sapiens_ENSP00000354877 DWGRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPS--TA--------------------VKQ-VVKNLNERYKFCITMCKKLTEKLNR-------FFSDKQRFI---DEINSVTAEKL O_latipes_ENSORLP00000018791 EWGQVEQLVLYMKAAQLLASSLHLAKAQIKSAKLNPS--SA--------------------VKQ-VVKSLNERYKSCISLCRQLTDKLNY-------FFSDKQRFV---DEINSVTAEKL T_nigroviridis_ENSTNIP00000017404 EWGQVEQLVLYMKAAQLLASSLHLAKAQIKSAKLNPS--TA--------------------VKQ-VVKNLNERYKSCISLCRQLTDKLNH-------FFSDKQRFV---DEINSVTAEKL T_nigroviridis_ENSTNIP00000008902 EWSHAEQLVLYLKSAELLSGALHTAMERVRQGKLYPS--AT--------------------VKQ-VVRKLNELYKSSVASCRSLSTRLER-------FFSRKHRLM---DQISSITAERL M_domestica_ENSMODP00000005348 DWGQVEQLVLYMKAAQLLASSLHLAKAQIKSGKLNPS--TA--------------------VKQ-VVKNLNERYKFCIAMCKKLTEKLNR-------FFSDKQRFI---DEINSVTAEKL T_guttata_ENSTGUP00000007355 EWGQVEQLVLYMKAAQLLASSLHLAKAQVKSGKLNPS--TA--------------------VKQ-VVKSLNERYKFCIGMCKKLTEKLNR-------FFSDKQRFI---DEINSVTAEKL T_rubripes_ENSTRUP00000015470 EWGQVEQLVLYMKAAQLLASSLHLAKAQIKSAKLNPS--TA--------------------VKQ-VVKNLNERYKSCISLCRQLTDKLNH-------FFSDKQRFV---DEINSVTAEKL O_anatinus_ENSOANP00000021856 EWSYAEQLVLYLKVAELLSSGLQTAIEQIKAGKLCLS--ST--------------------VKQ-VVRKLNELYKSSVSACHCLNVRLQR-------FFLDKQKLM---DRINSITAEKL G_gallus_ENSGALP00000007513 EWGQVEQLVLYMKAAQLLASSLHLAKAQVKLGKLNPS--TA--------------------VKH-VVKSLNERYKFCIGMCKKLTEKLNR-------FFSDKQRFI---DEINSVTAEKL G_gallus_ENSGALP00000003776 EWSYAEQLVLYLKVAELLSSGLQTAIEQIKAGKLCLS--ST--------------------VKQ-VVKKLNELYKSSVSSCHCLNMRLQR-------FFLDKQKLM---DQINSITAEKL G_aculeatus_ENSGACP00000016289 EWSYAEQLVLYMKAEEFLSSALHTAKETIKQGRLLPS--AT--------------------VKQAVIRKLNELYKSCVTYCRTLNHRLQT-------FLLDKQKLM---DRFNGLTAEKL O_latipes_ENSORLP00000013892 EWSFAEQLVLYLKTTELLSAALHSAMDQVKQGRLYPS--AT--------------------VKQ-ILKRLNELYKLSVASCRSLSTRLEH-------FFSRKHRLM---DRITSITAERL G_aculeatus_ENSGACP00000017889 EWGQVEQLVLYMKAAQLLASSLHMAKAQIKSTKLNPS--SA--------------------VKQ-VVKSLNERYKSCISFCRRLTDRLNH-------FFSDKQRFV---DEINSVTAEKL M_musculus_ENSMUSP00000108029 EWGFAEQLVLYLKVAELLSSGLQTAIDQIRAGKLCLS--ST--------------------VKQ-VVRRLNELYKASVVSCQGLSLRLQR-------FFLDKQRLL---DGIHGVTAERL H_sapiens_ENSP00000324560 EWGFAEQLVLYLKVAELLSSGLQSAIDQIRAGKLCLS--ST--------------------VKQ-VVRRLNELYKASVVSCQGLSLRLQR-------FFLDKQRLL---DRIHSITAERL R_norvegicus_ENSRNOP00000053633 EWGFAEQLVLYLKVAELLSSGLQTAIDQIRAGKLCLS--ST--------------------VKQ-VVRRLNELYKASVVSCQGLSLRLQR-------FFLDKQRLL---DGIHGVTAERL O_anatinus_ENSOANP00000020106 DWGQVEQLVLYMKAAQLLASSLHLAKAQIKSGKLNPS--TA--------------------VKQ-VVKNLNERYKFCIAMCKKLTEKLNH-------FFSDKQRFI---DEINSVTAEKL T_rubripes_ENSTRUP00000029855 EWSYAEQLVLYMKAEEFLSAALHTAKENINKGQLLPS--NI--------------------VKQ-VIRKLNESYKTCVTQCHSLNRRLQT-------FLLDKQKLI---DRFSGLTAEKL O_latipes_ENSORLP00000017355 EWSFAEQLVLYMKAEEFLSSALHTAKENIKQGQLQPS--SI--------------------VKQ-VIRKLNDLYKSCVSFCRSLNDRLQT-------FLLDKQKLM---DRFGGLTAEKL B_taurus_ENSBTAP00000017268 EWGFAEQLVLYLKVAELLSSGLQTAIDQIRAGKLCLS--ST--------------------VKQ-VVRKLNELYKTSVVSCQSLSLRLQR-------FFLDKQRLL---DRIQSVTAEKL G_aculeatus_ENSGACP00000023344 EWSHAEQLVLYLKTAELLSTALHTAMERVKQGKLYPS--ST--------------------VKQ-IVRRLNELYKSSVASCRSLSTRLER-------FFSRKHRLM---DQITSITAERL E_caballus_ENSECAP00000007293 DWGRVEQLVLYMKAAQLLASSLHLAKAQIKSGKLSPS--TA--------------------VKQ-VVKNLNERYKFCITMCKKLTEKLNR-------FFSDKQRFI---DEINSVTAEKL M_domestica_ENSMODP00000031918 EWRDGEQLGVSMTPAPLGGWSPWAGRKAGPRADLTRSLLAY--------------------LAV-VVRKLNELYKSSVSSCHCLNLQLQK-------FFLDKQKLM---DRINSITAEKL M_mulatta_ENSMMUP00000027852 DWGRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPS--TA--------------------VKQ-VVKNLNERYKFCITMCKKLTEKLNR-------FFSDKQRFI---DEINSVTAEKL A_carolinensis_ENSACAP00000000717 AWTQVEQLVLYMKAAQLLASSLHLAKAQIKSAKLNLS--TA--------------------VKQ-VVKNLNERYKFCICMCKRLTEKLNR-------FFSDKQRFV---DEVNSVTAEKL P_pygmaeus_ENSPPYP00000009920 DWGRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPS--TA--------------------VKQ-VVKNLNERYKFCITMCKKLTEKLNR-------FFSDKQRFI---DEINSVTAEKL C_familiaris_ENSCAFP00000026786 DWGRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPS--TA--------------------VKQ-VVKNLNERYKFCITMCKKLTEKLNR-------FFSDKQRFI---DEINSVTAEKL C_familiaris_ENSCAFP00000009679 EWGFAEQLVLYLKVAELLSSGLQTAIDQIRAGKLCLS--ST--------------------VKQ-VVRKLNELYKASVVSCQGLSLRLQR-------FFLDKQRLL---DRIQSVTAEKL E_caballus_ENSECAP00000014390 EWGFAEQLVLYLKVAELLSSGLQTAIDQIRAGKLCLS--ST--------------------VKQ-VVRKLNELYKASVVSCQGLSLRLQR-------FFLDKQRLL---DRIQSVTAEKL P_pygmaeus_ENSPPYP00000005848 ---FAEQLVLFMKVAELLSSGLQTAIDQIRAGKLCLS--ST--------------------VKQ-VVRRLNELYKASVVSCQGLSLRLQR-------FFLDKQRLL---DRIHSITAERL T_guttata_ENSTGUP00000008305 EWSYAEQLVLYLKVAELLSSGLQMAIEQIKAGKLCLS--ST--------------------VKQ-VVKKLNELYKSSVSSCHCLNMRLQR-------FFLDKQKLM---DRINSITAEKL M_mulatta_ENSMMUP00000020714 EWGFAEQLVLYLKVAELLSSGLQTAIDQIRAGKLCLS--ST--------------------VKQ-VVRRLNELYKASVVSCQGLSLRLQR-------FFLDKQRLL---DRVHSITAERL P_troglodytes_ENSPTRP00000009595 EWGFAEQLVLYLKVAELLSSGLQTAIDQIRAGKLCLS--ST--------------------VKQ-VVRRLNELYKASVVSCQGLSLRLQR-------FFLDKQRLL---DRIHSITAERL S_cerevisiae_YGL180W ILLCNEAIVLYMKALSILSKSMQVTSNWWYESQEKSC--SL--------------------RVNVLVQWLREKFNECLEKADFLRLKINDLRFKHASEVAENQTLEEKGSSEEPVYLEKL P_pygmaeus_ENSPPYP00000014729 Q----QGVTFDLQPMEWMAAATHALSAPAEVR-LTPP--GSCGFYDGLLILLLQLLTE-Q-GKASLIRDMSSSEMWTVLWHRFSMVLRLP----KEASAQEGELSLSSPPSPEP--DWTL M_mulatta_ENSMMUP00000008885 Q----QGVTFDLQPMEWMAAATHALSAPAEVR-LTPP--GSCGFYDGLLILLLQLLTE-Q-GKAGLIRDVASSEMWTVLWHRFSTVLRLP----KEASAQEGELLLSNPPSPEP--DWTL P_troglodytes_ENSPTRP00000022091 Q----QGVTFDLQPMEWMAAATHALSAPAEVR-LTPP--GSCGFYDGLLILLLQLLTE-Q-GKASLIRDMCSSEMWTVLWHRFSMVLRLP----EEASAQEGELSLSSPPSPEP--DWTL H_sapiens_ENSP00000295709 Q----QGVTFDLQPMEWMAAATHALSAPAEVR-LTPP--GSCGFYDGLLILLLQLLTE-Q-GKASLIRDMSSSEMWTVLWHRFSMVLRLP----EEASAQEGELSLSSPPSPEP--DWTL O_cuniculus_ENSOCUP00000001738 Q----QGVAFELQPAEWMAAATHALSAPAEXX-XXXX--XXXXXXXXXXXXXXXXXXX-Q-GKARLIRDVAGSELWTILWHRFSMALRLP----EEVPTLEEELLLSVPPSPEP--DWTL B_taurus_ENSBTAP00000038069 Q----QGVTFDLQPGEWIAAATHALSAPAEVR-LTPP--GGCGFYDGLLILLLQLLTQ-Q-GKGNPIRDMASSEMWTVLWHRFFMALRLP----EEASTQEEEVSLSSPQSPEP--DWTL C_familiaris_ENSCAFP00000021994 Q----QGVTFDLQPVEWIAAASHALSAPAEVR-LIPP--GCCGFYDGLLILLLQLLTQ-P-GKGSLLRDVADSEIWTVLWHRFSMALRLP----EEVSPQEEEPSLSRPQSPEP--DWTL G_gallus_ENSGALP00000018526 Q----RGVPVALQGKEILPAVTNALMEPAELH-FSLP--MGAGLYDGIIFLLLKLLAQ---EDVAVEQSFAASELWNVVWHCVPAVLCMG----SSGAALEGDSPGAGPPVAEP--DWSL R_norvegicus_ENSRNOP00000022839 Q----QGVTFDLQPREWIAAAAHALSAPAEVR-LTPP--CSCGFYDGLLVLLLQLLTQVQMGKPGLIRDVAGSEVWTILWHRFSMALRLS----EEVSAQEDDLSLSSPPSLEP--DWTL E_caballus_ENSECAP00000008449 Q----QGVPFDLQPVEWIAAATHALSAPAEVR-LTPP--DGCGFYDGLFILLLQLLSQ-E-GKGSLIREVASSEMWTVLWQRFSMALRLP----EEVSAQEEELSLCSPQSPGP--DWTL M_musculus_ENSMUSP00000084430 Q----QGVTFDLQPREWIAAAAHALSAPAEVR-LTPP--YSCGFYDGLLILLLQLLMQVQ-GKPGLIRDVVGSEVWTILWHRFSMALRLP----EEVSAQEDDLLLSSPSSLEP--DWTL M_domestica_ENSMODP00000019211 Q----QGVAFNLQPKEWIAAAAHALSAPAEL-----P--PGCFLF--------------Q-GGAEIVQDVANSELWTILWHRFFMTLRLS----EEVPTSEDKMSLPSQSVPEP--EWTL A_carolinensis_ENSACAP00000002909 Q----HGAAVKLRWEEALTAIATAFTESAEPC-LPPP--MGVGFYDGLLILLLHVLSEVC-GDVAMVREFAASELWGIVWHLFAMVLHMT----TQEPMLEGETSGAGQHAPEP--DWDL G_gorilla_ENSGGOP00000001881 Q----QGVTFDLQPMEWMAAATHALSAPAEVR-LTPP--GSCGFYDGLLILLLQLLTE-Q-GKASLIRDMSSSEMWTVLWHRFSMVLRLP----EEASAQEGELSLSSPPSPEP--DWTL G_aculeatus_ENSGACP00000012128 GPQASPP----FSHPHSLSPLMEPDEGLV--------------------------------------------YDPYTGHHHYAQ------------HPPPGSHLHHQLPHPLPHGASAG M_domestica_ENSMODP00000018106 SPQAQSPQPPQFSLAQSLSPVLEPSSEQMQ-------------------------------------------YDPFLSQYRKLQLQPLPSSQVPGSPPPLPSQLQQQPPQP---PAAPP C_intestinalis_ENSCINP00000014205 N----LGVVFHIGIDEFFSAISSAVSNLTEVDTLPP---SGHGILDGVIGMVQQLVTE---GDHQSVHGFITCGAWTALWYRLGHAINVDIKEDNETETLPSTRRITGPARCDDPYDPML D_rerio_ENSDARP00000081199 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000036932 TPQASPP----FTHTHSLSPLMEPGEGLV--------------------------------------------YDSYMS----------------------------------------- D_rerio_ENSDARP00000011264 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0112008 G------------ALERLTKIL-------------------------------------------------------------------------------------------------- D_melanogaster_FBpp0074373 --LAASDLFLNFLTHDFRQSDSDAASVRLAGCMLA--------------------------LMGCVLRELPENAEL----------------------------------------VERI 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0075677 LYDYALDMCQAAALDELLKNTKNCF-ERYNTAHILLHSLVQKCN---------------------------------------------------------------------------- A_gambiae_AGAP011295-PA IFEFALQMCQMAAVDELFNKPAECF-PRYQSAQILLHWLAQKSK---------------------------------------------------------------------------- A_aegypti_AAEL003819-PA LYDHAIRMCQTAALDELFGNPEDCF-SRYQSAQILLHSLAQKCS---------------------------------------------------------------------------- C_elegans_Y60A3A.1.1 MYRHAIELCQAAALDELFGNPQLCS-QRYQTAYMMLHTLAEQVN---------------------------------------------------------------------------- D_rerio_ENSDARP00000083843 IYNHAVEMVQSAALDEMFQQTEDIA-YRYNKASMLLEGLTKILQ---------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000003792 IYNCAVEMVQSAALDEMFQQTEDIV-QRYHKAALLLEGLSKILQ---------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000042372 IYNCAVEMVQSAALDEMFQQTEDIV-YRYHKAALLLEGLSKILQ---------------------------------------------------------------------------- B_taurus_ENSBTAP00000029699 IYNCAVEMVQAAALDEMFQQTEDIV-YRYHKAALLLEGLTKILQ---------------------------------------------------------------------------- M_musculus_ENSMUSP00000004920 IYNCAVEMVQSAALDEMFQQTEDIV-YRYHKAALLLEGLSKILQ---------------------------------------------------------------------------- H_sapiens_ENSP00000354877 IYNCAVEMVQSAALDEMFQQTEDIV-YRYHKAALLLEGLSRILQ---------------------------------------------------------------------------- O_latipes_ENSORLP00000018791 IYNHAVEMVQSAALDEMFKQTEDIA-YRYSKASMLLDGLSKILQ---------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000017404 IYNHAVEMVQSAALDEMFKQTEDIA-YRYSKASMLLDGLSKILQ---------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000008902 LFSHAVQMVQAAALDEMFHHGEASA-LRYHKALLLMEGLTLLLN---------------------------------------------------------------------------- M_domestica_ENSMODP00000005348 IYNCAVEMVQSAALDEMFQQTEDIV-YRYHKAALLLEGLTKILQ---------------------------------------------------------------------------- T_guttata_ENSTGUP00000007355 IYNCAVEMVQSAALDEMFQQTEDIT-YRYHKAALLLEGLTKILQ---------------------------------------------------------------------------- T_rubripes_ENSTRUP00000015470 IYNHAVEMVQSAALDEMFKQTEDIA-YRYSKASMLLDGLSKILQ---------------------------------------------------------------------------- O_anatinus_ENSOANP00000021856 IFSSAVQMVQSAALDEMFHHREDCV-QRYHKALLLMEGLLPIIT---------------------------------------------------------------------------- G_gallus_ENSGALP00000007513 IYSCAVEMVQSAALDEMFQQTEDIT-YRYHKAALLLEGLTKILQ---------------------------------------------------------------------------- G_gallus_ENSGALP00000003776 IFSYAVQMVQSAALDEMFHHREDCA-QRYHKALLLMEGLLNIIT---------------------------------------------------------------------------- G_aculeatus_ENSGACP00000016289 IYSHTVEMVQCAALDEMFHYGTASV-QRYHKALLLMEGLSRIIT---------------------------------------------------------------------------- O_latipes_ENSORLP00000013892 LFNHTVQMVQAAALDEMFHQGEASI-LRYHKALLLMEGLSLLLT---------------------------------------------------------------------------- G_aculeatus_ENSGACP00000017889 IYNHAVEIVQSAALDEMFKQTEDIA-YRYSKAAMLLDGLSKILQ---------------------------------------------------------------------------- M_musculus_ENSMUSP00000108029 ILSHAVQMVQSAALDEMFQHREGCV-PRYHKALLLLEGLQHTLT---------------------------------------------------------------------------- H_sapiens_ENSP00000324560 IFSHAVQMVQSAALDEMFQHREGCV-PRYHKALLLLEGLQHMLS---------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000053633 ILSHAVQMVQSAALDEMFQHRESCV-PRYHKALLLLEGLQHTLT---------------------------------------------------------------------------- O_anatinus_ENSOANP00000020106 IYNCAVEMVQSAALDEMFQQTEDIV-YRYHKAALLLEGLAKILQ---------------------------------------------------------------------------- T_rubripes_ENSTRUP00000029855 LYNHTVHMVQSAALDEMFHCGSASL-QRYHKALLLMEGLYRIVT---------------------------------------------------------------------------- O_latipes_ENSORLP00000017355 IYSHTVHMVQSTALDEMFHYGTSSV-QRYNKALLLMEGLSRILT---------------------------------------------------------------------------- B_taurus_ENSBTAP00000017268 IFSHAVQTVQSAALDEMFHRREDCV-QRYHKALLLMEGLQQILT---------------------------------------------------------------------------- G_aculeatus_ENSGACP00000023344 LFSHTVQMVQTAALDEMFHQGEASV-LRYHKALLLMEGLSLLLT---------------------------------------------------------------------------- E_caballus_ENSECAP00000007293 IYNCAVEMVQSAALDEMFQQTEDIV-YRYHKAALLLEGLTKILQ---------------------------------------------------------------------------- M_domestica_ENSMODP00000031918 IFNYAVQMVRSAALDEMFHHREDCV-QRYHKALLLMEGLQQILT---------------------------------------------------------------------------- M_mulatta_ENSMMUP00000027852 IYNCAVEMVQSAALDEMFQQTEDIV-YRYHKAALLLEGLTKILQ---------------------------------------------------------------------------- A_carolinensis_ENSACAP00000000717 IYSCAVEMVQSAALDEMFQQTEDIA-YRYHKAALLLEGLAKILQ---------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000009920 IYNCAVEMVQSAALDEMFQQTEDIV-YRYHKAALLLEGLSKILQ---------------------------------------------------------------------------- C_familiaris_ENSCAFP00000026786 IYNCAVEMVQSAALDEMFQQTEDIV-YRYHKAALLLEGLTKILQ---------------------------------------------------------------------------- C_familiaris_ENSCAFP00000009679 IFSHAVQTVQSAALDEMFHRREDCV-QRYHKALLLMEGLQHILT---------------------------------------------------------------------------- E_caballus_ENSECAP00000014390 IFSHAVQMVQSAALDEMFHRREDCV-QRYHKALLLMEGLQHILT---------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000005848 IFSHAVQMVQSAALDEMFQHREGCV-PRYHKALLLLEGLQHMLS---------------------------------------------------------------------------- T_guttata_ENSTGUP00000008305 IFSYAVQMVQSAALDEMFHHREDCA-QRYHKALLLMEGLLNIIT---------------------------------------------------------------------------- M_mulatta_ENSMMUP00000020714 IFSHAVQMVQSAALDEMFQHREGCV-PRYHKALLLLEGLQHMLS---------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000009595 IFSHAVQMVQSAALDEMFQHREGCV-PRYHKALLLLEGLQHMLS---------------------------------------------------------------------------- S_cerevisiae_YGL180W LYDRALEISKMAAHMELKGENLYNCELAYATSLWMLETSLDDDD---------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000014729 ISPQGMAALLSLAMATFAQEPQLCLSCLSQHGSILMSILKHLLCPSFLNQLR-QAPHG----SEFLPVVVLSVCQLLCFPFALDMDADLLIGVLADLRDSEVAAHLLQVCCYHLPLTQVE M_mulatta_ENSMMUP00000008885 ISPQGMAALLSLAMATFTQEPQLCLSCLSQHGSILMSILKHLLCPSFLNQLR-HAPHG----SEFLPVVVLSVCQLLCFPFALDVDADLLIDILADLRDSEVAAHLLQVCCYHLPLTQVE P_troglodytes_ENSPTRP00000022091 ISPQGMAALLSLAMATFTQEPQLCLSCLSQHGSILMSILKHLLCPSFLNQLR-QAPHG----SEFLPVVVLSVCQLLCFPFALDMDADLLIGVLADLRDSEVAAHLLQVCCYHLPLMQVE H_sapiens_ENSP00000295709 ISPQGMAALLSLAMATFTQEPQLCLSCLSQHGSILMSILKHLLCPSFLNQLR-QAPHG----SEFLPVVVLSVCQLLCFPFALDMDADLLIGVLADLRDSEVAAHLLQVCCYHLPLMQVE O_cuniculus_ENSOCUP00000001738 ISPQGMAALLSLAMATFTQEPQLCLSHLSQRGNILMSTLKHLLSPNFLHHLG-QAPHG----PEFLPVVVLSVCQLLCFPFSLDVDADLLVGILADLRDSEVAAHLLQVCCHRLPXXXXX B_taurus_ENSBTAP00000038069 ISPQGMAALLSLAMATFTQEPQLCLSHLSQRGSILMSTLKHLLSPSFLHHLG-QAPQG----SEFLPVVVLSVCQLLCFPFALDVDADLLEGVLADLTDSEVTAHLLQVCCHHLPLTQVE C_familiaris_ENSCAFP00000021994 ISPQGMAALLSLAVATFTQEPQLCLSHLSQRGSILMSTLKHLLSPSFLRQLG-RAPQG----AEFLPVVVLSVCQLLCFPFALDVDADLFRGVLADFVDSEVAAHLLQVCCHHLPLPQVE G_gallus_ENSGALP00000018526 LSPQGTLLFLSLALLIFTRETHRCLPQLTQSRGVFMVMLKTLLSPRFLACLA-QTQAGENGEAELIPAVVIQACQLLCFPFALDVDEDTIALVIEAVRDSQIPPQLLQVCCHHLPFSDTE R_norvegicus_ENSRNOP00000022839 ISPQGMAALLSLAMAIFTQEPQLCLSHLSQHGSVLMLTLKHLLSPSFLHRLS-QAPQG----SEFLPVVVLSVCKLLCFPFALDVDADLLGGILADLRASEVAVYLLQVCCHHLPLFQAE E_caballus_ENSECAP00000008449 ISPQGMAALLSLAVASFTQEPQLCLSHLSQRGSILMSTLKHLLSPSFLHQLG-QAPHG----SEFLPVMVLSVCQLLCFPFALDVDADLLVGVLADLTNSEVTAHLLQVCCHHLPLPQVE M_musculus_ENSMUSP00000084430 ISPQGMAALLSLAMAIFTQESQLCLSHLSQHGSVLMLTLKHLLSPSFLHHLS-QAPQG----PEFLPVVVLSVCKLLCFPFALDVDADLLVGVLADLRASEVVVCLLQVCCHHLSLLQAE M_domestica_ENSMODP00000019211 ISPQGITALLNVALAVFTQEPHLCLPYLIQHNSILMSTLKHLLSPIFLQQLG-QTQHG----SELLPAVVLPVCQLLCFPFAMDVDVDVLLNILADLRDSEVPAHLLQVCCRYLLLPQAE A_carolinensis_ENSACAP00000002909 ISPQGTPFFLSLTLFVFTCEPHQCLLQMAQPNGLIMAVLNKLLDPDFLEQLH------EDGDLELVTTTVLQVCQVFCFAFAMDMDPEILEQILTNMKGSEIPAQLLQVCIHHLPCTKTE G_gorilla_ENSGGOP00000001881 ISPQGMAALLSLAMATFTQEPQLCLSCLSQHGSILMSILKHLLCPSFLNQLC-QAPHG----SEFLPVVVLSVCQLLCFPFALDMDADLLIGVLADLRDSEVAAHLLQVCCYHLPLMQVE G_aculeatus_ENSGACP00000012128 SLGFSFPVGCEQHAMGPFGEGVHQERYEFQLDPA----LLRPPAPGEAVARMLACPG--------------------------------------------------------------- M_domestica_ENSMODP00000018106 PLPFSYQTRELPGAAPP--EPDYPAPCQYSMDPAQQSNVALPDCPRSSGPR--ESPS--------------------------------------------------------------- C_intestinalis_ENSCINP00000014205 MSPDAVLSFLSLATSVFTWEPSKSLPLFSLSNGIVLMSLVALLSDEFISSPNIQLLTNEEDLPILLEELVVENLQCLCFPFAIELSEQKLQQVIACFSELDVIPLILHRCVQNISHRSLE D_rerio_ENSDARP00000081199 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000036932 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000011264 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0112008 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0074373 VFNPRLNFVSLLQSRHHLLRQRSCQ-LLRLLARFSLRGVQRIWNGELRFALQ-------------------------------------------------------------------- 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 1800 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0075677 ------------------------------------------------H--PQDKMMLN--KYRDAVEKRLSILQQHGYIYMTDENA--------------------------------- A_gambiae_AGAP011295-PA ------------------------------------------------H--PQDKILLS--NYKEAVEKRLYILKGQGYIYTTDELS--------------------------------- A_aegypti_AAEL003819-PA ------------------------------------------------H--PKDKELLS--TYKDAVEKRLYILQQQGYIYERS------------------------------------ C_elegans_Y60A3A.1.1 ------------------------------------------------C--DQDKTVLT--RYKVAVEKRLRILERQGFVAAVNT----------------------------------- D_rerio_ENSDARP00000083843 ------------------------------------------------D--PADIENVI--KYKASVDRRISALCYCTVTL--------------------------------------- R_norvegicus_ENSRNOP00000003792 ------------------------------------------------D--PADAESVH--KYKCSIERRLSALCCSTAAV--------------------------------------- P_troglodytes_ENSPTRP00000042372 ------------------------------------------------D--PADIENVH--KYKCSIERRLSALCHSTATV--------------------------------------- B_taurus_ENSBTAP00000029699 ------------------------------------------------D--PADIENIH--RYKSSIERRLSALCYSTSAL--------------------------------------- M_musculus_ENSMUSP00000004920 ------------------------------------------------D--PTDVENVH--KYKCSIERRLSALCCSTATV--------------------------------------- H_sapiens_ENSP00000354877 ------------------------------------------------D--PADIENVH--KYKCSIERRLSALCHSTATV--------------------------------------- O_latipes_ENSORLP00000018791 ------------------------------------------------D--PTDVENVM--KYKASVDRRISTLCYCTVTLYE------------------------------------- T_nigroviridis_ENSTNIP00000017404 ------------------------------------------------D--PTDVENVV--KYKASVDRRISALCYCTVT---------------------------------------- T_nigroviridis_ENSTNIP00000008902 ------------------------------------------------E--RDDIMSIS--RCKECIERRLTALQSGLCV---------------------------------------- M_domestica_ENSMODP00000005348 ------------------------------------------------D--PADIENVHKCKYKSSIERRLSALCYGAVT---------------------------------------- T_guttata_ENSTGUP00000007355 ------------------------------------------------D--PADIENVH--KYKSSIERRLSALCYSTVAVYEQ------------------------------------ T_rubripes_ENSTRUP00000015470 ------------------------------------------------D--PTDVENVV--KYKASVDRRISALCYCTVT---------------------------------------- O_anatinus_ENSOANP00000021856 ------------------------------------------------E--QTDIENIN--KCKMCIERRLSALLSGICA---------------------------------------- G_gallus_ENSGALP00000007513 ------------------------------------------------D--PADIENVH--KYKSSIERRLSALCCSTVAVYEQ------------------------------------ G_gallus_ENSGALP00000003776 ------------------------------------------------E--QGDIENIN--KCKLCIERRLSALLSGFCA---------------------------------------- G_aculeatus_ENSGACP00000016289 ------------------------------------------------E--EKDIDSIE--KCKQCIERRLSAL---------------------------------------------- O_latipes_ENSORLP00000013892 ------------------------------------------------Q--QEDILSVS--KCKECIERRLTTLQSGLCV---------------------------------------- G_aculeatus_ENSGACP00000017889 ------------------------------------------------D--PTDIENVV--KYKASVDRRISALCYCTVTL--------------------------------------- M_musculus_ENSMUSP00000108029 ------------------------------------------------D--QADIENIA--KCKLCIERRLSALLSGVYA---------------------------------------- H_sapiens_ENSP00000324560 ------------------------------------------------D--QADIENVT--KCKLCIERRLSALLTGICA---------------------------------------- R_norvegicus_ENSRNOP00000053633 ------------------------------------------------D--QADIENIA--KCKLCIERRLSALLSGVYA---------------------------------------- O_anatinus_ENSOANP00000020106 ------------------------------------------------D--PGDIENVH--KYKSSIERRLSALCYSTVTV--------------------------------------- T_rubripes_ENSTRUP00000029855 ------------------------------------------------E--QKDIDSID--KCKQCIERRLSAL---------------------------------------------- O_latipes_ENSORLP00000017355 ------------------------------------------------E--QRDIDSID--KCKECIEKRISAL---------------------------------------------- B_taurus_ENSBTAP00000017268 ------------------------------------------------D--QADVENIA--KCKLCIERRLSALLTGICA---------------------------------------- G_aculeatus_ENSGACP00000023344 ------------------------------------------------E--QDDILSVS--KCKECIERRLTALQSGLCV---------------------------------------- E_caballus_ENSECAP00000007293 ------------------------------------------------D--PADIENVH--KYKSSIERRLSALCYSASAM--------------------------------------- M_domestica_ENSMODP00000031918 ------------------------------------------------E--QADIENIN--KCKMCIERRLSAL---------------------------------------------- M_mulatta_ENSMMUP00000027852 ------------------------------------------------D--PADIENVH--KYKCSIERRLSALCHSTATV--------------------------------------- A_carolinensis_ENSACAP00000000717 ------------------------------------------------D--PADIENIN--KYKASIERRLSALCYGAVAV--------------------------------------- P_pygmaeus_ENSPPYP00000009920 ------------------------------------------------D--PADIENVH--KYKCSIERRLSALCHSTATM--------------------------------------- C_familiaris_ENSCAFP00000026786 ------------------------------------------------D--PADIENVH--KYKTSIERRLSALCCSTATL--------------------------------------- C_familiaris_ENSCAFP00000009679 ------------------------------------------------D--QADVENIA--KCKLCIERRLSALLTGISA---------------------------------------- E_caballus_ENSECAP00000014390 ------------------------------------------------D--QADVENIA--KCKLCIERRLSALLTGICA---------------------------------------- P_pygmaeus_ENSPPYP00000005848 ------------------------------------------------D--QADIENVA--KCKLCIERRLSALLTGICA---------------------------------------- T_guttata_ENSTGUP00000008305 ------------------------------------------------E--QGDIENIS--KCKLCIERRLSALLSGFCA---------------------------------------- M_mulatta_ENSMMUP00000020714 ------------------------------------------------D--QADIENVA--KCKLCIERRLSALLTGICA---------------------------------------- P_troglodytes_ENSPTRP00000009595 ------------------------------------------------D--QADIENVT--KCKLCIERRLSALLTGICA---------------------------------------- S_cerevisiae_YGL180W ---------------------FTNAYGDYPFKTNIHLKSNDVEDKEKYHSVLDENDRIIIRKYIDSIANRLKILRQKMNHQN-------------------------------------- P_pygmaeus_ENSPPYP00000014729 LPISLLTRLALTDPTSLNQFVNT---VAASPRTIISFLSVALLSDQPLL--TSDLLSLLAHTARVLSPSHLSFIQELLAGSDESYQSLRSL-LGHPENSVRAHTYRLLGHLLQHSMALRG M_mulatta_ENSMMUP00000008885 LPISLLTRLALTDPTSLNQFVNT---VAASPRTIVSFLSVALLSDQPLL--TSDLLSLLAHTARVLSPSYLSFIQELLAGSDESYRPLRSF-LGHPENSVRAHTYRLLGHLLQHSMALRG P_troglodytes_ENSPTRP00000022091 LPISLLTRLALMDPTSLNQFVNT---VSASPRTIVSFLSVALLSDQPLL--TSDLLSLLAHTARVLSPSHLSFIQELLAGSDESYRPLRSL-MGHPENSVRAHTHR-VGHLLQHSMALR- H_sapiens_ENSP00000295709 LPISLLTRLALMDPTSLNQFVNT---VSASPRTIVSFLSVALLSDQPLL--TSDLLSLLAHTARVLSPSHLSFIQELLAGSDESYRPLRSL-LGHPENSVRAHTYRLLGHLLQHSMALRG O_cuniculus_ENSOCUP00000001738 XXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXX B_taurus_ENSBTAP00000038069 LPISLLTRLALSDPAFLNQFVNT---VVASPRTTVSFLSTALLGDQPLL--TSDLLSLLAHTARLLSPSHLSFIHELLAGSDESYRPLRSL-LSHPETSVRARTYGLLGHLLQHSMALRG C_familiaris_ENSCAFP00000021994 LPVSLLTRLALTDLTSLNQFVNT---VAASPRTVISFLSVALLGDQPLL--TSDLLSLLAHTARVLSPSHLSFIQELLAGSDESYRPLRSL-LGHPEHSVRARTYGLLGHLLQHSMALRG G_gallus_ENSGALP00000018526 LPMSLLCRLVVSDEQVTDQIAR----EAATSEHIIAYLSTVLFSGSLTL--TTDLLSLLTHVART-CPEHLPFLQRILGGSDMSYQALTHL-LSHQEHPIRAKTCNLLGNLLRHSHGFPQ R_norvegicus_ENSRNOP00000022839 LPIGLLTRLALMDPTSLKQFVNT---VATSSRAIISFLSVVLLCDQPLM--VSDLLSLLTHTTRILSPSHLSFIQELLSGSDESYRPLRSL-LGHSENAVRVRTYRLLGHLLQHSMALRG E_caballus_ENSECAP00000008449 LPISLLTHLALMDSTSLNQFVNT---VAASPRSMISFLSIALLGDQPLL--TSDLLSLLAHTVRVLSPSHLSFIQELLAGSDESYRPLRS--WAHPENSVRARTYGLLGHLLQHSMALRG M_musculus_ENSMUSP00000084430 LPIGLLTRLALTDSASLKQFVNT---VATSSRAIISFLSVVLLSDQPLM--ISDLLSLLTHTARILSPSHLSFIQELLSGSDESYRPLRSL-LGHSENTVRVRAYGLLGHLLQHSMALRG M_domestica_ENSMODP00000019211 LPVSLLARLALTDSTTLNQFVAS---VAASPNT-ITFLSAALLGDQPLL--TSDILSLLAHAARAWPPTHLPFLQDLLAGPDESYWPLRCL-LGHPENPVRARAYGLLGHLLHQSTALRG A_carolinensis_ENSACAP00000002909 LPLSLLCRLVLSDEEIIEQVVG-----AATSQDAIDFLSSIFLSDQVHL--LADLLTLLTHIARA-SPSHLPFLEKLLSGS--TSQALSHL-LGHSECLVRARTCSLVGNLLRHGQEFPH G_gorilla_ENSGGOP00000001881 LPISLLTRLALMDPTSLNQFVNT---VSASPRTIVSFLSVALLSDQPLL--TSDLLSLLAHTARVLSPSHLSFIQELLAGSDESYRPLRSL-LGHPENSVRAHTYRLLGHLLQHSMALRG G_aculeatus_ENSGACP00000012128 ---------------------------------------------------QSDSLGLPELQGSLLDSEMMETVDSQHGFVLVN------------------------------------ M_domestica_ENSMODP00000018106 ---------------------------------------------------SYDPLALSELPG-LFDCEMVEAVDPQPSGYVLCSRQEA------------------------------- C_intestinalis_ENSCINP00000014205 VPMRLISKLCSHHPPSLDRFIHICSHSSTKSSNIVKYLRQTLISPDATSATKSELLGFLNFAVRSKPAKHSSLASEIFFCFNKHHPPAATLCFECTDIEVQTQACLLLGNLL-------- D_rerio_ENSDARP00000081199 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000036932 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000011264 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0112008 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0074373 ------------------------------------------------Q--LSEHHSYP--ALRGEAAQTLDEISHFTFFVT-------------------------------------- 1810 1820 1830 1840 1850 1860 1870 1880 1890 1900 1910 1920 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0075677 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011295-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003819-PA ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y60A3A.1.1 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000083843 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000003792 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000042372 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000029699 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000004920 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000354877 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000018791 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000017404 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000008902 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005348 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000007355 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000015470 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000021856 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000007513 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000003776 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000016289 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000013892 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000017889 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108029 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000324560 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000053633 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000020106 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000029855 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000017355 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000017268 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023344 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000007293 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000031918 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000027852 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000000717 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000009920 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000026786 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000009679 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000014390 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005848 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000008305 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000020714 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000009595 ------------------------------------------------------------------------------------------------------------------------ S_cerevisiae_YGL180W ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014729 ALQSQSGLLSLLLLGLGDKDPVVRCSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDPQAGIRRNVASALGNLGPEG--LGEELLQCQVPQRLLEMACGDPQPNVKEAALIALRSLQQE M_mulatta_ENSMMUP00000008885 ALQSQSGLLSLLLLGLGDKDPVVRCSASFAVGNATYQAGPLGPALAVAVPSMTQLLGDPQAGIRRNVASALGNLGPEG--LEEELLQCQVPQRLLEMACGDPQPNVKEAALIALRSLQQE P_troglodytes_ENSPTRP00000022091 ----------------GDKDPFVRCSASFAVGNAAYQAGLLRPALAAAVPSMTQLLGDPQAGIRRNVASALGNLGPEG--LGEELLQCEVPQRLLEMACGDPQPNVKEAALIALRSLQQE H_sapiens_ENSP00000295709 ALQSQSGLLSLLLLGLGDKDPVVRCSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDPQAGIRRNVASALGNLGPEG--LGEELLQCEVPQRLLEMACGDPQPNVKEAALIALRSLQQE O_cuniculus_ENSOCUP00000001738 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX B_taurus_ENSBTAP00000038069 ALQSQAGLLNLLLLGLGDKDPAVRRGASFAVGNAAYQAGPLGPALAAAVPGMTQLLEDPQAGIRRNAVSALGNLGPEG--LGEELLQCQVPQRLLEMACGDPQPNVKEAALVALRSLRQE C_familiaris_ENSCAFP00000021994 ALQSQAGLLNLLLLGLGDKDPAVRRSASFAVGNAAYQAGPLGPALAAAVPGMTQLLEDPQAGIRRNAVSALGNLGPEG--LGAELLQYQVPQRLLEMACGDPQLNVKEAALIALRSLRQE G_gallus_ENSGALP00000018526 VLQNQPGLLESLLVCLADEDEAVRKAASFAVGNAAYHESSPAGTLGRAVPRLTQLLSDRQAKTRCNAASALGNLGRRSAELGELLIESGAPRILLEMACRDPQASVREGALMALRAVSQH R_norvegicus_ENSRNOP00000022839 ALQSQSGLLNLLLLGLGDKDPAVRRSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDAQDAIRRNAASALGNLGPEG--LGKELLKCQVPQRLLEMACGDPQPTVKEAALIALRSLRQE E_caballus_ENSECAP00000008449 ALQ-QTGLLNLLLLGLGDKDPAVRRSASFAVGNAAYQAGPLGPALAAAVPGMTQLLGDPQAGIRRNAASALGNLGPEG--LGEELLQCQVPQRLLEMACGDPQPNVKEAALIALRSLRQE M_musculus_ENSMUSP00000084430 ALQSQSGLLNLLLLGLGDKDPAVRRSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDAQDGIRRNAASALGNLGPEG--LGKELLKCQVPQRLLEMACGDPQPTVKEAALIALRSLQQE M_domestica_ENSMODP00000019211 ALQSQAGLLSLLLAGLRDKDPAVRRSASFAVGNAAYQAGPLAPALVPAVPRVTQLLGDPQTGTRRNAASALGNLGPEG--LGEELLRCQVPHRLLETACGDPQPTVREAALIALRSLRQE A_carolinensis_ENSACAP00000002909 ILQGQVGLLKSLLERLSDEDRHVRRSASFAVGNAAYQAGPFMQDLRKAVPCVVRLLGDPQAKTRCNAASALGNLGWQSVELGDSLIQNKAPNILLDVACHDSQPAVQKAALIALRSMSHQ G_gorilla_ENSGGOP00000001881 ALQSQSGLLSLLLLGLGDKDPVVRCSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDPQAGIRCNVASALGNLGPEG--LGEELLQCEVPQRLLEMACGDPQPNVKEAALIALRSLQQE G_aculeatus_ENSGACP00000012128 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000018106 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000014205 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000081199 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000036932 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000011264 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0112008 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0074373 ------------------------------------------------------------------------------------------------------------------------ 1930 1940 1950 1960 1970 =========+=========+=========+=========+=========+===== D_melanogaster_FBpp0075677 ------------------------------------------------------- A_gambiae_AGAP011295-PA ------------------------------------------------------- A_aegypti_AAEL003819-PA ------------------------------------------------------- C_elegans_Y60A3A.1.1 ------------------------------------------------------- D_rerio_ENSDARP00000083843 ------------------------------------------------------- R_norvegicus_ENSRNOP00000003792 ------------------------------------------------------- P_troglodytes_ENSPTRP00000042372 ------------------------------------------------------- B_taurus_ENSBTAP00000029699 ------------------------------------------------------- M_musculus_ENSMUSP00000004920 ------------------------------------------------------- H_sapiens_ENSP00000354877 ------------------------------------------------------- O_latipes_ENSORLP00000018791 ------------------------------------------------------- T_nigroviridis_ENSTNIP00000017404 ------------------------------------------------------- T_nigroviridis_ENSTNIP00000008902 ------------------------------------------------------- M_domestica_ENSMODP00000005348 ------------------------------------------------------- T_guttata_ENSTGUP00000007355 ------------------------------------------------------- T_rubripes_ENSTRUP00000015470 ------------------------------------------------------- O_anatinus_ENSOANP00000021856 ------------------------------------------------------- G_gallus_ENSGALP00000007513 ------------------------------------------------------- G_gallus_ENSGALP00000003776 ------------------------------------------------------- G_aculeatus_ENSGACP00000016289 ------------------------------------------------------- O_latipes_ENSORLP00000013892 ------------------------------------------------------- G_aculeatus_ENSGACP00000017889 ------------------------------------------------------- M_musculus_ENSMUSP00000108029 ------------------------------------------------------- H_sapiens_ENSP00000324560 ------------------------------------------------------- R_norvegicus_ENSRNOP00000053633 ------------------------------------------------------- O_anatinus_ENSOANP00000020106 ------------------------------------------------------- T_rubripes_ENSTRUP00000029855 ------------------------------------------------------- O_latipes_ENSORLP00000017355 ------------------------------------------------------- B_taurus_ENSBTAP00000017268 ------------------------------------------------------- G_aculeatus_ENSGACP00000023344 ------------------------------------------------------- E_caballus_ENSECAP00000007293 ------------------------------------------------------- M_domestica_ENSMODP00000031918 ------------------------------------------------------- M_mulatta_ENSMMUP00000027852 ------------------------------------------------------- A_carolinensis_ENSACAP00000000717 ------------------------------------------------------- P_pygmaeus_ENSPPYP00000009920 ------------------------------------------------------- C_familiaris_ENSCAFP00000026786 ------------------------------------------------------- C_familiaris_ENSCAFP00000009679 ------------------------------------------------------- E_caballus_ENSECAP00000014390 ------------------------------------------------------- P_pygmaeus_ENSPPYP00000005848 ------------------------------------------------------- T_guttata_ENSTGUP00000008305 ------------------------------------------------------- M_mulatta_ENSMMUP00000020714 ------------------------------------------------------- P_troglodytes_ENSPTRP00000009595 ------------------------------------------------------- S_cerevisiae_YGL180W ------------------------------------------------------- P_pygmaeus_ENSPPYP00000014729 PGIRQVLVSLGASEKLALLSLGNQLLPHS---SPRPASAKHCRKLIHLLRPAHSM M_mulatta_ENSMMUP00000008885 PGIHQVLVSLGASEKLALLSLGNQSLPHS---SPRPASAKHCRKLIHLLRPTHSM P_troglodytes_ENSPTRP00000022091 PGIHQVLVSLGASEKLSLLSLGNQSLPHS---SPRPASAKHCRKLIHLLRPAHSM H_sapiens_ENSP00000295709 PGIHQVLVSLGASEKLSLLSLGNQSLPHS---SPRPASAKHCRKLIHLLRPAHSM O_cuniculus_ENSOCUP00000001738 XXXXXVLVSLRASDKLALLSLGNQ-LPHS---SARPASARHCRKLIQLLRPTHDT B_taurus_ENSBTAP00000038069 PCIHQVLVSLGASEKLALLSLGNQLLPHS---SPRPASAKHCRKLIHLLRPTHST C_familiaris_ENSCAFP00000021994 PCIHQVLVSLGASERLAMLSLGNQLLVHS---SPRPASARHCRKLIHLLRPTHST G_gallus_ENSGALP00000018526 PGIQQVLLSLRATDQLAALAGGDSW--TTAGGSPRPSSARHCQKLIRLLTPLQST R_norvegicus_ENSRNOP00000022839 PCIHQVLVSLGASEKLTLLSLGHQLLPSS---NSRPTSARHCRKLIHLLRPTHST E_caballus_ENSECAP00000008449 PCIHQVLVSLGASEKLALLSLGNPSLPHS---SPRPASAKHCRKLIHLLRPTHST M_musculus_ENSMUSP00000084430 SCIHQVLVSLGASEKLALLSLGNQLLPNS---SNRPASVRHCRKLIQLLRPTHST M_domestica_ENSMODP00000019211 PSIHQVLVSLDASEKLASLSSASPLPPHSSSGSPRPSSARHCKKLIHLLRPAHST A_carolinensis_ENSACAP00000002909 PRIRQVLVSLRACEKLEALTLDQFQ--NSAYSHPWPSSTQHCKKLIQLLQPSQSA G_gorilla_ENSGGOP00000001881 PGIHQVLVSLGASEKLALLSLGNQSLPHS---SPRPASAKHCRKLIHLLRPAHSM G_aculeatus_ENSGACP00000012128 ------------------------------------------------------- M_domestica_ENSMODP00000018106 ------------------------------------------------------- C_intestinalis_ENSCINP00000014205 ------------------------------------------------------- D_rerio_ENSDARP00000081199 ------------------------------------------------------- T_rubripes_ENSTRUP00000036932 ------------------------------------------------------- D_rerio_ENSDARP00000011264 ------------------------------------------------------- D_melanogaster_FBpp0112008 ------------------------------------------------------- D_melanogaster_FBpp0074373 -------------------------------------------------------