>D_melanogaster_FBpp0076076 ------------------------------------------------------------ ---------MQP----PELEIGMPKRHREHIRKNLNILVEW------------------T NYERLAMECVQ-QG-ILTVQMLRNTQDLNGKPFNMDEKDVRVEQHRR------------- ------------------------------------LLLKITQRGPTA------------ ------------------------------------------------------------ -----------------------------------------------YNLLINALRNINC LDAAVLLES-------V------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -DESDSRPPFISLNE--RRTSRKSADIVDTPSPEASEGPCVSKLRNEPLGALTPYVGVVD GPEVKKSKKIHG----GDSAIL-GTYKMQSRFNRGVLLMVNIMDYP--DQN--------- RRRIGAEKDSKSL-IHLFQELNFTIFPYGNVNQDQFFKLLTMVTSSSYVQNTECFVMVLM THGNS---VEGKEKVEFCDGS-------VVDMQKIKDHFQTAKCPYLVNKPKVLMFP--F CRGDEY-DLGHPKN--QGN-LMEPVYTAQEEKWPD---------TQTEGIPSPSTNVPSL ADTLVCYANTP--G--YVTHRDLDTGSWYIQKFCQVMAD-------HA--HDTDLE---- -------DILKKTSEAVGNKR---T-------KKGSMQTGAYDNL-----GFNKKLYFNP G-FFNE------------- >A_aegypti_AAEL011562-PA ------------------------------------------------------------ ----------------------MDQRDRHQIQHNMDQLIQH------------------T NYGVLMAECVG-RQ-MMSEVMKAIIEDR-----YPDE----ASRHKK------------- ------------------------------------LFEKITKRGPHA------------ ------------------------------------------------------------ -----------------------------------------------FDILVSICQRNFP TAYKLLKNG-------NVSTVGSS------------------------------------ ------------------------------------------------------------ --------------------------------------SRNSSQFEFNSTYHPNRVRSIS AGDYSGSELLRQRL---ANLSIGSPSYSEEDDAKNNNDTVEETTDKGGKRRLQEFGEKVR SLYKVELSARP-----QSHRIL-EAYEMRRR-NRGVVFIVNVITYI--NET--------H PTRNGAEADKYNL-VSLFQQLGFTVFYYEDLTSDEFNNLIKELKQS-SYLSTECFVFYIL AHGNH---TKGRDKIYLNDNS-------VLYVEDVLALFNNANCPKLIRRPKLFFFS--I CRGDNP-DYGTLRL--AEH-TERD--------------------GMINLKKDPPTNMPTY ADMLICFSTVP--G--YAAHRDKQYGSWFVESMCKVWAQ-------HA--HDTDVE---- -------QLMKLVGKDSSTYR---T------EHHNALQTLGSEQR-----GFFNVLYLNP G-YYED------------- >A_gambiae_AGAP004754-PA ------------------------------------------------------------ ----------------------MNNKDRFLITHNVEKLVNY------------------T NYKQLSFECIQ-QK-MLSPTMVSRIEGI-----AQDE----VTRHKK------------- ------------------------------------LFEKITKRGPKA------------ ------------------------------------------------------------ -----------------------------------------------FDTLLAICQQAFP TAYLIL------------------------------------------------------ ------------------------------------------------------------ --------------------------------------KPNSNDNQMHSTHNPQRVRSVS CNVAPKVYSLR--------------SPGDVDDGKNNNFASNALVEE-SKCILQVYPDILP TTFSVKLSTRPA----ETHPKV-PAYPMKGR-NRGVAFIVNVITFL--KKV--------H PTRNGADIDGRNL-ISVFQQLGFVVFYYEDITMGDLKELLAQLKES-EHLSCDCFAFYIL SHGDH---RKGSDYIFLHDNS-------LLRVEDLLTEFNSVNCKRLVHKPKLFFIS--I CRGVQS-DLGAYRL--STN-TERD--------------------GMIDPGKPLPSNIATY CDMLVCYATVP--G--FAAHRDTNTGSWFVESMCKIWSE-------HA--HDTDVE---- -------ILMKLVGEYASSYR---T-------EHSALQTICTEQR-----GFFKQLFLNP G-YYENPVEL--------- >C_intestinalis_ENSCINP00000003204 ------------------------------------------------------------ ------------------MSLKSAADVLMSGVPTPHTNENN------------------N VGQSEVDALGS-G----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E TPRIYSLPDVTK----MASSEV-ECYQMDRE-SRGLALIINNENFH--HAT-------RM NKRSGTDVDARNL-SRIFKKLGFDVQVYKDLSCISMLEVINEVSTM-DHTGNDCCFVAFL SHGDD-------GCVYGTDGI--------VQIKKIVDQFRGDVCPSLAGKPKIFLFQ--A CRGTLH-ETSVQLS--VDV-VDGE------------------DQPCVEVDAAPVPTLPSG SDYLFCYSVAE--G--YYSHRDTLYGSWFIQDFTDVMEQLVLNKGKQQ--DKVDFI---- -------DVLTVVNRKVSARR---VER-SYSQQALGKKQMPCYLS-----MLTKKLYLTP KK----------------- >D_rerio_ENSDARP00000047019 ------------------------------------------------------------ ----------------------MEQKHRQILQRHRLNLVKA------------------L NPEDVCDKLLS-KG-VFTQDMIDEIQSKA----TRRD------QARQ------------- ------------------------------------LVKDLETRGSLA------------ ------------------------------------------------------------ -----------------------------------------------FPAFLDSLRETGH NDLAELLQS--------------------------------------------------- ------------------------------------------------------------ --------------------------------GDGVHRPPVISVQPSPIPLPVQNL---- -----------------NHTEKPDKPDIASPRLVPLR-------------PESLPVHKTY SPPSETVVRPTR----PRRDSI-QCYKMDAS-PCGVCLIINNINFE--KAS-------EL NDRKGSNIDCDKL-EKRFKALNFEVTVKRNLKSKRIRHEMASLAKK-DHSTYDCCVVIIL SHGTEASHNRFPGAVHGVDGP-------AVPIQIITNYLNGQNCPSLQGKPKLFFIQ--A CGGGEK-DIGFEVS--PDD-VQPSIGGIDDEMDAIPMSSSSDSLSTASDELDARASLPTP SDILVSYSTFP--G--YVSWRDTEAGSWYVENLDRVLEE-------NA--ITDDLV---- -------TMLMLVNDAVSQIS-----------AKGLYKQMPGSFN-----FLRKLLYFQS SQS---------------- >D_rerio_ENSDARP00000093958 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MKHA-KRGLALIFNQKDFS--L-L-------GL KTRKGTDKDRDSL-VSRFEELDFEVKAYNDYSRDKVLKEIKEVAAA-DHVDADCFVCIFL SHGED-------GHVYANDEK--------IKIPEITDLFKGDKCRGLVGKPKIFIWQNKA CRGDKK-DDPVAPM--SAEDSD----------------------DEMAVDAGVSNTLPAG ADFIMCYSTTE--G--FCSFRDPLNGTWYIQDLCEIMGR-------YR--SQLEFT---- -------NILTLVNRKVSLRS---I---CDDLSATGTKQMPCFAS-----MLTKRLFFRP K-K---------------- >X_tropicalis_ENSXETP00000052017 ------------------------------------------------------------ --------MASA----KQQSSPSAGQIEKDSSSASQ-NKEQ------------------K ANVAETDGWTS-RT---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------LELDPS-AEYKMTHK-RRGLALIFNHEDFY--WQL-------RL GSRRGTNTDSMNL-NRILTDLGFDVQNYYNLRTLDILEKIQEASTA-DHSNADCFLCVFL SHGED-------RHIYSYDSL--------IDIQELTNSFKGDKCESLVGKPKIFIFQ--A CRGEKH-DNPVLPT--DETDSVT-------------------LTNITEVDAASLYTLPAG ADFIMCYSVAE--G--YYSHRETVNGSWYIQDLCEVLKA-------HA--ASLEFT---- -------EILTLVNRKVSQRS---VAF-CNDPKAIGKKQIPCFSS-----MLTKKLFLKP K-SN--------------- >G_gallus_ENSGALP00000013506 -----------------------------------------LKSFKPHWISSNMEDDDSL QFRQLLLLIDEG----LGAEDVAALKFLCTDLIPFRKLESV------------------Q SAMDIFQLLID-ED-YLNEEDTFLLAELLYRIKYHS------------------------ ------------------------------------LLSKLGYTKEKVQECL--HEKGKV SPY--------------------------------------------------------- -------RQMLYELSENITNDMLQEIVFLLRNHLPKRRR--TISALELLILLEKQCLLTE NNVQILEEV-------FRNVSPDLLETVKCYR---------------------------- ------------------------------------------------------------ -------------------------------------------MAKVALPHQGNTLPIKE SSPS-YTVHVRLFNS--PQGGSFILVLNESYCESLRNKKYSVTGASAACHAI-SMPSTGV QNALANTTVCYS-----SFLQV-SSYKMDGP-RRGICLVINNVKFD--G---------VL QERKGSYKDACEL-ERVFTWLGLDVRTYTDQTSDQIKELMQAWQRSEDHKNRDCFVCCIL SHGES-------GAVYGKDGK-------LVSIRTIMTYFTAKQCPQLTEKPKLFFVQ--A CQGKEV-QRPVYVE--TDA-RVPDFSSVPQ-------------------STSPSESIPEE ADFLLGMATID--G--YASFRHVQEGTWYIQALCSKLQL-------LVPSRGEDIL---- -------SILTEVNEDVSKRV---D-------RYGTRKQMPQPAY-----TLRRKLIFPI P-RDPPPS----------- >P_troglodytes_ENSPTRP00000048878 ------------------------------------------MKSQGQHWCSSSDKNCKV SFREKLLIIDSN----LGVQDVENLKFLCIGLVP-KKLEKS------------------S SASDVFEHLLA-ED-LLSEDDPFFLAELLYIIRQKK------------------------ ------------------------------------LLQHLNYTKEEVERLL--PTRQRV SLF--------------------------------------------------------- -------RNLLYELSEGIDSENLKDMIFLLKDSLPKTEM----TSLSFLAFLEKQGKIDE DNLTCLEDL-------CTTVVPKLLRNIEKYK---------------------------- ------------------------------------------------------------ -------------------------------------------REKAV---QIVTPPVDK EAES-YQGEEELVSQ--TDVKTFLEALPQ---ESW-QNKHAGSNGNRATNGAPSLVSRGM QGASANTLNSET-----STKRA-TVYRMNRN-HRGLCVIVNNHSFT------------SL KDRQGTHKDAEIL-SHVFQWLGFTVHIHNNVTKVEMEEVLQRQKCNPAHADGDCFVFCIL THGRF-------GAVYSSDEA-------LIPIREIMSHFTALQCPRLAEKPKLFFIQ--A CQGEEI-QPSVSIE--ADA-LNPE-----------------------KAPTSLQDSIPAE ADFLLGLATVP--G--YVSFRHVEEGSWYIQSLCNHLKK-------LVP-RMLKFLEKTM EIRGRKRTVWGAKQTQISATS---L-------PKAISAQTPRPPM-----HRWSSVS--- ------------------- >T_rubripes_ENSTRUP00000022652 ------------------------------------------------------------ ------------------------GSDAELGKTATD-SSAC------------------T GDLMETDAISG-SI---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------GFLDPA-EEYKMDNK-RRGLALIFNQERFF--WRL-------GL RDRHGTNADSYNL-QRRLKELNFEVKVFDNHTQAQVLEIITSAAKD-DHSNVDCFLVVFL SHGEN-------DHIYTFDDK--------INVQDITSLFKGDKCKSLVGKPKIFILQ--A CRGDKH-DEPATAAAFDDVDSE-------------------LKKNEVEVDASAVYTLPAG ADFIMCYSVAE--G--YYSHRETVNGSWYIQDLCDLLRK-------YG--DSLEFT---- -------ELLTLVNRKVSMRS---VGY-CSDPNAIGKKQVPCFAS-----MLTKKLYFRP K-K---------------- >C_familiaris_ENSCAFP00000016791 ------------------------------------------------------------ --------------------------SSATCGLRRAYRTAD------------------E QNVTETDAFYK-R----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------EMFDPE-EKYKMDHK-RRGIALIFNHERFF--WHL-------TL PDRRGTSADRDNL-VRRFSELGFEVKCFNDLKAEELLLKIHEASTS-SHIDADCFLCVFL SHGEG-------NHIYAYDAK--------IEIQTLTGLFKGDKCQSLVGKPKIFIIQ--A CRGDQH-DVPVLPL--DVVDHRTD----------------KLEDNVTEVDAASVYTLPAG ADFLMCYSVAE--G--YYSHRETVNGSWYIQDLCEMLGK-------FG--SSLEFT---- -------ELLTLVNRKVSQRR---VDF-CKDPNAIGKKQVPCFAS-----MLTKKLHFFP K-SK--------------- >M_domestica_ENSMODP00000005560 ------------------------------------------------------------ -MEDTGTTVDAK----SIKNSGVKS----------------------------------L HSSKSVESGLS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------S-DSYKMDYP-EMGLCVIINNTHFH--NDT-------EL SPRTGSDKDAANL-IDIFRSLKYEVRNKNNLTRDKMIELLRQVSEE-DHSQRSSFVCVIL SHGEE-------GVIFGTDDS--------VELKELTYFFKGYKCKSLTGKPKLFIIQ--A CQGREF-DCGVETD--SGT-DE----------------------------DVACHKIPVE ADFLYAYSTVP--G--YYSLRDPKDGSWFIQALCAVLKQ-------HA--HKLEIM---- -------QILTRVNRKVATEF---ESY-SSKASLHAKKQMPCIMS-----MLTKELYFSH ------------------- >C_familiaris_ENSCAFP00000017933 ------------------------------------------MTSQAQSLTFRSDDNCQS SFRGKLLTIDSK----LEIQDVEGLKFLCRDFVSHKKLEKS------------------N SASDIFDHLLA-EE-LLSEEDPFFLAELLYIIKQNS------------------------ ------------------------------------LLRYLNQSKEQVESLL--PTRRRV SLF--------------------------------------------------------- -------RNLLYELSESIGSENLKDMIFLQRDSMPKTQL----TPLSFLAYLEKQALIDE DNLGLLEDL-------CRKVVPNLIRKIERYK---------------------------- ------------------------------------------------------------ -------------------------------------------REKAS---EVVTPPVDT ETESLHQKEEELFSP--SDINQFHGALSK--QTSWNPLKHRAKQGNIISDGA-TLVSVEM LEASTGPLTSET-----STKEA-NVYRMDRK-HRGHCVIVNNHTFA------------KM PDRPGTDKDAECL-SRVFQWLGFSVHVYKNVTKGHLDEVLQEFKCHPDHVDGDCFVFCVL THGKF-------GAVYSSDGT-------LVPIREIMSHFTAQKCPGLAHKPKLFFIQ--A CQGKGI-QTPVSIE--ADA-VNPE-----------------------HVSPSLKDSIPDA ADFLLGLATVP--G--YVSFRHVEKGSWYIQSLCNRLKS-------LVP-RHEDIL---- -------SILTAVNNDVSQQA---D-------KQGTMKQMPQPAY-----TLRKKLVFPV P-QKELLL----------- >M_domestica_ENSMODP00000007353 ------------------------------------------------------------ ----------------------------KSFGLFFVFEGDA------------------E QNATEIDAFFK-S----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------KPLDPA-EQYKMDHK-RRGVALIFNHERFF--WHL-------TL PERRGTRADRDNL-RQRLSDLGFEVNCFDDLKAEDLLMTIHMVSTS-SHIDADCFLCVFL THGEG-------NHIYAYDAK--------IDIQKLTAMFKGDKCQTLVGKPKIFVIQ--A CRGDQH-DIPVIPL--DVVDHLSD----------------KVDVNETEVDAASVYTLPAG ADFLMCYSVAE--G--YYSHRETVHGSWYIQDLCEMLEK-------YG--SSLEFT---- -------ELLTLVNRKVSQRR---VDF-CKDPNAIGKKQVPCFAS-----MLTKKLYLFP K-PK--------------- >O_anatinus_ENSOANP00000015596 ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------AG--TRRD------QARQ------------- ------------------------------------LVTDLETRGRRA------------ ------------------------------------------------------------ -----------------------------------------------LSVFISCLRETDQ HALAALLSE--------------------------------------------------- ------------------------------------------------------------ -------------------------------------GCQAPQVTPV--DIRPVEIIRPG GQGDVCKYSKIHPK-----CYSPPLPFQSTSPLRGKEQWTGSVKPFV--------PVPST TKREQEATRPGE----KQGMAI-KVYSLKSE-PCGHCLIINNVDFS--LGS-------GL STRTGSDVDCEKM-KRRFRLLHFEVAVERNLTAEEMVKALNKLAKK-DHSALDCCVVVIL SHGYQASHIQFPGGIHGTDGE-------SISVETIVNYFNGSRCPSLGGKPKLFFIQ--A CGGEKK-DPGFEVN--LDS-PEDHPTGSDPESDAAPFQAAPEDY----DEPDAVASLPTP SDILVSYSTFP--G--FVSWRDTQSGSWYIETLDSVLDQ-------WA--HTEDLL---- -------TLLLRVSNGVSSKG--------------KYKQIPGCFN-----FLRKRLFFNT K------------------ >T_guttata_ENSTGUP00000004278 ------------------------------------------------------------ ----------MS----GSERRPPAGHVQLDSRPTLP-TTDG------------------N ENITEVDALNI-R----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------QSLDPA-EEYKMNHQ-RRGLALIFNHERFY--WHL-------RL QDRRGTWVDRNNL-KSILTELGFEVRLFDDLKKEDVQQRIYEASTA-DHSNADCFVCVFL SHGED-------GHIFAYDDK--------IEIQTITDMFRGDKCQSLVGKPKIFIIQ--A CRGDKH-DDAVIAH--DSADGS------------------ESPGNETDVDAAGVYTLPAG ADFIMCYSVAQ--G--YYSHRDTINGSWYIQDLCETLRK-------HG--SSLEFA---- -------ELLTVVNRKVSCRR---VGM-CKDINAIGKKQIPCFAS-----MLTKKLYFHP K-SK--------------- >G_aculeatus_ENSGACP00000023055 ------------------------------------------------------------ ----------MS----DTTGDGRGGRVASPNKAATD-RAAC------------------T ENLTETDALIR------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------SSLDPA-EEYKMDNK-RRGLALIFNQERFF--WRL-------GL NDRHGTNADRYNL-ERRLSNLNFDVRAYDNLKQEEVLNKINEAAEE-NHSDSDCFLLVFL SHGEN-------DQVYTYDGK--------ISVQDITSLFKGDKCKSLVGKPKIFILQ--A CRGDKH-DDPVTAC--DAVDSE-------------------LKTNEVVVDASVLHTLPAG ADFIMCYSVAE--G--YYSHRETINGSWYIQDLCELLQR-------YG--DSHEFT---- -------EVLTLVNRKVSMRS---VGN-SSDRSAIGKKQVPCFAS-----MLTKKLYFRP K-Q---------------- >A_carolinensis_ENSACAP00000012644 ------------------------------------------------------------ ------------------------------------------------------------ --------FRR-N----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------HLFDPA-AEYKMSHK-RRGLALIFNHEHFF--WHL-------ML PERRGTQADKENL-KRGLTDLGFEVKCFDDLKAEEVLQNIYNVSTD-EHDDADCFLCVFL SHGED-------DHVYAYDAK--------IEIKSLTNMFKGDKCPSLVGKPKIFVIQ--A CRGDKH-DDPVIAR--DTVDSK-K----------------ELDINETEVDTAAVYTLPAG ADFLMCYSVAE--G--YYSHRETINGSWYIQDLCEMLKR-------HG--SSLEFT---- -------DLLTLVNRKVSHRE---VDV-CKDRKALGKKQIPCFAS-----MLTKKLYFRP K-FK--------------- >H_sapiens_ENSP00000286186 ------------------------------------------MKSQGQHWYSSSDKNCKV SFREKLLIIDSN----LGVQDVENLKFLCIGLVPNKKLEKS------------------S SASDVFEHLLA-ED-LLSEEDPFFLAELLYIIRQKK------------------------ ------------------------------------LLQHLNCTKEEVERLL--PTRQRV SLF--------------------------------------------------------- -------RNLLYELSEGIDSENLKDMIFLLKDSLPKTEM----TSLSFLAFLEKQGKIDE DNLTCLEDL-------CKTVVPKLLRNIEKYK---------------------------- ------------------------------------------------------------ -------------------------------------------REKAI---QIVTPPVDK EAES-YQGEEELVSQ--TDVKTFLEALPQ---ESW-QNKHAGSNGNRATNGAPSLVSRGM QGASANTLNSET-----STKRA-AVYRMNRN-HRGLCVIVNNHSFT------------SL KDRQGTHKDAEIL-SHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCIL THGRF-------GAVYSSDEA-------LIPIREIMSHFTALQCPRLAEKPKLFFIQ--A CQGEEI-QPSVSIE--ADA-LNPE-----------------------QAPTSLQDSIPAE ADFLLGLATVP--G--YVSFRHVEEGSWYIQSLCNHLKK-------LVP-RHEDIL---- -------SILTAVNDDVSRRV---D-------KQGTKKQMPQPAF-----TLRKKLVFPV P-LDALSL----------- >T_guttata_ENSTGUP00000017449 ------------------------------------------------------------ ----------------------MEERQRRALRRGRARLVAA------------------L RVEPLWEPLEQ-RG-LFTRPMLEELQSAG----SRGE------QARQ------------- ------------------------------------LIIDLETRGKQA------------ ------------------------------------------------------------ -----------------------------------------------FPAFLSILRDTGQ GHLAEMLMQ--------------------------------------------------- ------------------------------------------------------------ -------------------------------------ECESRPVPPQLPDLRPVELELQ- ------------------------------------------EANQRCAVVLQTAARDVA AGIPLTVGKSPE----VMSFII-LDYEMKAD-PCGHCLILNNVNFC--RDS-------GL STREGSDIDCEKL-ERRFKALCFTVLTRRDLKAQEMVLELLKLSRQ-DHSALDCCIVVIL SHGCQTSHIQFPGGVYGTDGK-------PIPIEKIVNYFNGSSCPSLRGKPKLFFIQ--A CGGEQR-DQGFVVD--CDS-PKEEALGDSLESDAIPFRVPSDNV----DEPDAIASLPTP SDILVSYSTFP--G--FVSWREKSSGSWYVETLDSVLEQ-------YA--HSEDLL---- -------SMLVRVAHAVSARG--------------RYKQIPGCFN-----FLRKKFFFVC R------------------ >E_caballus_ENSECAP00000013268 ------------------------------------------------------------ ---------------------------------------GE------------------E QNMTEIDAFYK-R----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------EMFDPA-EKYKMDHK-RRGIALIFNHERFF--WHL-------TL PDRRGTSADRDNL-MRRFSDLGFEVKCFNDLKAEELLLKIYEVSTS-SHADADCFVCVFL SHGEG-------NHIYAYDAK--------IEIQTLTGLFKGDKCQSLVGKPKIFIIQ--A CRGDQH-DVPVTPL--DVVDHGTD----------------KLDANVTQVDAASVYTLPAG ADFLMCYSVAE--G--YYSHRETINGSWYIQDLCEMLAR-------FG--SSLEFT---- -------ELLTLVNRKVSQRR---VDF-CKDPSAIGKKQVPCFAS-----MLTKKLHFFP K-SK--------------- >T_nigroviridis_ENSTNIP00000021186 ------------------------------------------------------------ ------------------------------------------------------------ --RMETDAFYG-RN---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------SIVDPA-EEYKMDNK-RRGLAIIFNQESFF--WRL-------GL KDRHGTNADSYNL-QRRLRELNFDVNVYNNYKQQEVLDIINAAAKA-DHSDVDCFLLVFL SHGEN-------DHIYANDDK--------ISIQDITSLFKGDKCKSLVGKPKIFIWQ--A CRGDKH-DEPATAAAFDDVDSE-------------------SKKNEVEVDASAVHTLPAG ADFIMCYSVAE--G--YYSHRETVNGSWYIQDLCDLLLR-------YG--DSLEFT---- -------ELLTLVNRKVSMRS---VGY-CRDPNAIGKKQVPCFAS-----MLTKKLYFRP K-KKSK------------- >T_rubripes_ENSTRUP00000045375 ------------------------------------------------------------ ----------------------MEERHKKILQRNRTNLVGE------------------L DPSSLYDGLIE-KR-VFTHDMIDEIKSSG----TRRD------QARQ------------- ------------------------------------LIRDLETRGSRA------------ ------------------------------------------------------------ -----------------------------------------------FPLFLECLQETGH HTLVELLQD--------------------------------------------------- ------------------------------------------------------------ -------------------------------------GGPAVQIQP-PTPVPIDRPVIQP LPVCKSAI-----------RSRVLRGTMTVKAAPPVDVVRRDKAPVIPVPQPSTAPSPSP EREYMRLKPQGR----IRRDSI-QSYKMDAN-PSGHCLIINNVDFE--PRS-------EL NDRKGSNTDCDRL-ESRFKALNFIVKVKTNLKQRQIKHELSALSKM-DHSQYDCCVVVLL SHGTEVSHSRFPGAVYGVDGQ-------FVPVQHITTYLNGQHCPSLQGKPKLFFIQ--A CGGDEK-DTGFEVS--PDE-FEPPVVSAHDQTDAIPMSSSSDSLS-MSDEPDARASLPTP SDILVSYSTFP--G--YVSWRDTQSGSWYIETLDRILEE-------NA--ATDDLV---- -------TMLMMVNHEVSQNQ-----------AKGLYKQMPGSFN-----FLRKLLYFQS ------------------- >T_nigroviridis_ENSTNIP00000013855 ------------------------------------------------------------ ----------------------MEERHKKILQRNRINLVSE------------------L EPLNLYDGLIE-KG-VFTHDMIDEIKCSG----ARRD------QARQ------------- ------------------------------------LVRDLETRGSRA------------ ------------------------------------------------------------ -----------------------------------------------FPAFLECLKETGY HSLAELLQN--------------------------------------------------- ------------------------------------------------------------ -------------------------------------GAPTVQIQP-PTPIPVDRPVIQP LPISPPLV-------------------------PP-------EEPVSPVPKPSTPGRASP EVEYVTLK--GR----IRRDSL-QSYRMEAN-PLGHCLIINNVEFE--PKS-------GL SNRNGSNVDCDRL-ERRFKALNFTVKVKTNLKQRQIRQELSALSKV-DHSQYDCCVVVIL SHGTEVSHSRFPGAVYGVDGQ-------FVPVQHIATYLNGQYCPSLQGKPKLFFIQ--A CGGDEK-DTGFQVS--PDE-FEPPVVGADDQTDAIPVSSSSDSLS-MSDEPDARASLPTS SDILVSYSTFP--G--YVSWRDPKAGSWYVETLDRVLEE-------NA--ALHDLV---- -------VMLTMVNDEVSQNQ-----------AKGLYKQMPGSFN-----FLRKRLYFIA QP----------------- >P_pygmaeus_ENSPPYP00000014602 ------------------------------------------MKSQGQHWCSSSDKNCKV SFREKLLIIDSN----LGVQDVENLKFLCVGLVPNKKLEKS------------------S SASDVFEHLLA-ED-LLSEEDPFFLAELLYIIRQKK------------------------ ------------------------------------LLQHLSYTKEEVEGLL--PTRQRV SLF--------------------------------------------------------- -------RNLLYELSEGIDSENLKDMIFLLKDSLPKTEM----TSLSFPAFLEKQGKIDE DNLTCLEDL--------KTVVPKLLRNIEKYK---------------------------- ------------------------------------------------------------ -------------------------------------------REKAV---QIVTPPIDK EAES-YQGEEELVSQ--TDVKTFLEALPQ--EESW-QNKHAGSNGNRATNGAPSLVSRGM QGASANTLNSET-----GTKGR-KGYRMNRN-HRGLC-LLNNHSFT------------SL KDRRGTHKDAEIL-SHVFQWLGFTVHIHNNVTKGEMEEVLQEQKCNPAHADGDCFVFCIL THGKF-------GAVYSSDEA-------LIPIREIMSHFTALQCPRLAEKPKLFFIQ--A CQGEEI-QPSVSIE--ADA-LNPE-----------------------QPPTSLQDSIPAE ADFLLGLATVP--G--YVSFRHVEEGSWYIQSLCNHLKK-------LVP-RHEDIL---- -------SILTAVNDDVSRRV---D-------KQGTKKQMPQPAF-----TLRKKLVFPV P-LDALSL----------- >R_norvegicus_ENSRNOP00000013049 ------------------------------------------------------------ ------------------------------------------------------------ --MTETDGFYRSR----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------EVLDPA-EQYKMDHK-RRGTALIFNHERFF--WHL-------AL PERRGTNADRDNL-TRRFSELGFEVKCFNDLRAEELLLKIHEVSTS-SHVDADCFLCVFL SHGEG-------NHIYAYDAK--------IEIQTLTGLFKGDKCQSLVGKPKIFIIQ--A CRGSQH-DVPVVPL--DVVDHQTD----------------KLDDNVTQVDAASVYTLPAG ADFLMCYSVAE--G--YYSHRETVNGSWYIQDLCEMLAR-------HG--SSLEFT---- -------ELLTLVNRKVSQRR---VDF-CKDPGAIGKKQVPCFAS-----MLTKKLHFCP K-PSK-------------- >M_mulatta_ENSMMUP00000037898 ------------------------------------------------------------ ------------------------------------------------------------ ---------------MRIPTKWFYL----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------FFKRA-PTYRMDRN-HRGLCVIVNNHSFI------------SL RDRRGTHKDAEIL-KGVFQWLGFTVHIYNNVTKGEMEEVLQKEKCNPAHADGDCFVFCIL THGED-------GAVYSSDEA-------LIPIREIMSHFTALQCPGLAEKPKLFFIQ--A CQGEKI-QLSKSIE--ADA-LNPE-----------------------QAPTSLQDSIPVE ADFLLGLATVP--G--YVSFRHVEEGSWYIQSLCNHL----------------------- ------------------------------------------------------------ ------------------- >G_gorilla_ENSGGOP00000007184 -----------------------------------------------MADDQGCVXXXXX XXXXXXXXXXXX----XXXXXXXXXXXX-XXXXXXXX----------------------- XXXXXXXXXXX------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------X-XXXXXXXX-XXXXXXXXXXXXFD--KVT-------GM GVRNGTDKDAEAL-FKCFRSLGFDVIVYNDCSCAKMQDLLKKASEE-DHTNAACFACILL SHGEE-------NVIYGKDGV--------TPIKDLTAHFRGDRCKTLLEKPKLFFIQ--A CRGTEL-DDGIQAD--SGP-IN----------------------D---TDANPRYKIPVE ADFLFAYSTVP--G--YYSWRSPGRGSWFVQALCSILEE-------HG--KDLEIM---- -------QILTRVNDRVARHF---ESQ-SDDPRFHEKKQIPCVVS-----MLTKELYFSQ ------------------- >C_intestinalis_ENSCINP00000002956 ------------------------------------------------------------ ---------------------AMKKRHRNTLIKNRVKLAKC------------------L HLDEVLQYLVQ-CG-ILTDVTVERITSK----PTRFS------QNVA------------- ------------------------------------FLTCLPTRGPRA------------ ------------------------------------------------------------ -----------------------------------------------YGTFLEALRISSQ EHLVDILEK-------V------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----DISNAIPNNKP--ITPTTLHATITSNVHSEFVCARRQPMEIGKCEDKNDAKDGHNR --LRVQNSTVAF----FNETYN-SGYKMTTK-SRGYALIVCIGRFN--AGV-------RL PDRQGTDADKKNL-LAIFEQINYKTILVENCNKFEMERRVKQFAQMEEHRKCDSCAVAIL SHGSK-------TDIYASDGR-------SIPIESLIKMFDNVNCPPLRNKPKIFFIQ--C CRGNNM-DQGIDAT--DGP-PTLNSETSDS-------------------YNSTTHNITTD VDII--STASK--R--NAALRNTRHGSWYIQVLVKTIAQ-------HA--HEMDLL---- -------EILTLVNSAIKSKE---G--HSTDFDSQGVKEMSEFHS-----TLCKKLFFYP G-IVQTE------------ >M_musculus_ENSMUSP00000029626 ------------------------------------------------------------ ------------------------------------------------------------ --MTETDGFYKSR----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------EVFDPA-EQYKMDHK-RRGVALIFNHERFF--WHL-------TL PERRGTNADRDNL-TRRFSDLGFEVKCFNDLRAEELLLKIHEVSTS-SHIDADCFICVFL SHGEG-------NHVYAYDAK--------IEIQTLTGLFKGDKCQSLVGKPKIFIIQ--A CRGSQH-DVPVVPL--DMVDHQTD----------------KLD-NVTQVDAASVYTLPAG ADFLMCYSVAE--G--YYSHRETVNGSWYIQDLCEMLAR-------YG--SSLEFT---- -------ELLTLVNRKVSQRR---VDF-CKDPDAIGKKQVPCFAS-----MLTKKLHFCP K-PSK-------------- >C_intestinalis_ENSCINP00000007986 ------------------------------------------------------------ ----------------------MLSTHKEKLRTNRHTLCKE------------------L VVDELLQELIG-EG-IFNDILADRVLSH----QRDFK------KNVE------------- ------------------------------------FLTLLPGRGPNA------------ ------------------------------------------------------------ -----------------------------------------------FNAFRIALINSDQ SHLAELLDP-------AQGVSQPNESNANDGSGGPELSASIFRFESIATANSNLPGTSGT SAPLSRRRPMENTDQSSTSIASSQVIYANQGTPPKRNRESS------------------- ------------------------------------------SYIEQMDDAPSPTDSLSN IRSTASVHSLFSRSD--VRTQSNTAINHINTVQSPTSTKAATSYQINLHQGMDLFDGPTV SDLTVRKSTHQH----LMQHTDCYQMTMRGR-PKGAALIISVEKFH--PES-------DL LNREGSEKDRVRL-ELVLQQIGFQCYVLINGTAEQIVSTLQTFAELEEHYDNSCSLVAAM SHGDA-------GCFYGSDGV-------SVAIDTVVNFFSNQNCHSLQKKPKIFLFQ--A CQGDEY-DMGVDEV--DGP-VQAPVGDVDN-------------TSTSSSNDHIRNKLPQK SDMLIGQATMK--G--FAAMRNTKHGSWYIQAFVRVLAR-------HA--CDTDLL---- -------DMMTKVNNILKHKE---G--WCPGSVYHRCKVMPEFKS-----SLSKKLYFFP G-I---------------- >H_sapiens_ENSP00000265164 ------------------------------------------------------------ --------------------------MSSASGLRRGHPAGG------------------E ENMTETDAFYK-R----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------EMFDPA-EKYKMDHR-RRGIALIFNHERFF--WHL-------TL PERRGTCADRDNL-TRRFSDLGFEVKCFNDLKAEELLLKIHEVSTV-SHADADCFVCVFL SHGEG-------NHIYAYDAK--------IEIQTLTGLFKGDKCHSLVGKPKIFIIQ--A CRGNQH-DVPVIPL--DVVDNQTE----------------KLDTNITEVDAASVYTLPAG ADFLMCYSVAE--G--YYSHRETVNGSWYIQDLCEMLGK-------YG--SSLEFT---- -------ELLTLVNRKVSQRR---VDF-CKDPSAIGKKQVPCFAS-----MLTKKLHFFP K-SN--------------- >G_aculeatus_ENSGACP00000007379 ------------------------------------------------------------ ----------------------MEEIHKRILQRNRINLVRD------------------L DPSSLYDGLLE-KG-VFTQDMIDEIKSAG----TRRD------QARK------------- ------------------------------------LVQDLETRGSRA------------ ------------------------------------------------------------ -----------------------------------------------FAMLLLCLEETDQ HGLAELLQR--------------------------------------------------- ------------------------------------------------------------ -------------------------------------AAPAVQIWP-AAP---NQPFVLM LNS----------------REKTTSPSIQYRNPVPVHLTHCD------------AHVTAP ERENTLTRPPGR----TRRDSI-QSYKMDAS-PCGHCLIINNVEFE--PDS-------EL SNRKGSNIDCDKL-EKRFKALNFIVEVRTNLKQRQIKHALSALSKK-DHSQCDCCVVIML SHGTEVSHNRFPGAVYGVDGQ-------HVPVQLITNYLNGQHCPSLQGKPKLFFIQ--A CGGGER-DTGFEVS--PDE-VEPSIGGADDQTDAIPMSSSSDSLS-LSDEVDARATLPTP SDILVSYSTFP--G--YVSWRDTQSGSWYVETLDQVLEQ-------NA--ATDDLV---- -------TMLMMVNHEVSQNS-----------AKGLYKQMPGSFN-----FLRKLLHFQT HA----------------- >H_sapiens_ENSP00000351273 MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKM DFSRNLYDIGEQ----LDSEDLASLKFLSLDYIPQRKQEPI------------------K DALMLFQRLQE-KR-MLEESNLSFLKELLFRINRLDL----------------------- ------------------------------------LITYLNTRKEEMERELQTPGRAQI SAY--------------------------------------------------------- -------RVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGE GKLDILKRV-------CAQINKSLLKIINDYE---------------------------- ------------------------------------------------------------ -------------------------------------------EFSKERSSSLE------ --------------------------------------GSPDEFSN-------GEELCGV MTISDSPREQDS----ESQTLD-KVYQMKSK-PRGYCLIINNHNFA--KAREKVPKLHSI RDRNGTHLDAGAL-TTTFEELHFEIKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCIL SHGDK-------GIIYGTDGQ-------EAPIYELTSQFTGLKCPSLAGKPKVFFIQ--A CQGDNY-QKGIPVE--TDS-EE-QPYLEMD------------------LSSPQTRYIPDE ADFLLGMATVN--N--CVSYRNPAEGTWYIQSLCQSLRE-------RCP-RGDDIL---- -------TILTEVNYEVSNKD---D-------KKNMGKQMPQPTF-----TLRKKLVFPS D------------------ >H_sapiens_ENSP00000358327 --------------MDCVGWPPGRKWHLEKNTSCGGSSGICASYVTQMADDQGCIEEQGV EDSANEDSVDAK----PDRSSFVPSLFS-KKKKNVTM----------------------- RSIKTTRDRVP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------T-YQYNMNFE-KLGKCIIINNKNFD--KVT-------GM GVRNGTDKDAEAL-FKCFRSLGFDVIVYNDCSCAKMQDLLKKASEE-DHTNAACFACILL SHGEE-------NVIYGKDGV--------TPIKDLTAHFRGDRCKTLLEKPKLFFIQ--A CRGTEL-DDGIQAD--SGP-IN----------------------D---TDANPRYKIPVE ADFLFAYSTVP--G--YYSWRSPGRGSWFVQALCSILEE-------HG--KDLEIM---- -------QILTRVNDRVARHF---ESQ-SDDPHFHEKKQIPCVVS-----MLTKELYFSQ ------------------- >P_pygmaeus_ENSPPYP00000014606 -----------------------------------------------------------M DFSRNLYDIGEQ----LDSEDLASLKFLSLDYIPQRKQEPI------------------K DALMLFQRLQE-KR-MLEESNLSFLKELLFRINRLDL----------------------- ------------------------------------LITYLNTRKEEMERELQTPGRAQI SAY--------------------------------RFHFCRMSWAEANSQCQTQSVPFWW RVDHILIRVMLYQISEEVSRSELRCFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGK GKLDILKRV-------CAQINKSLLKIINDYE---------------------------- ------------------------------------------------------------ -------------------------------------------EFSR------------- -----------------------------------------------------GEELCGV MTISDSPREQDS----ESQTLD-KVYQMKSK-PRGYCLIINNHNFA--KAREKVPKLHSI RDRNGTHLDAGAL-TTTFEELHFEIKPHNDCTVEQIYEILKIYQLM-DHSNMDCFICCIL SHGDK-------GIIYGTDGQ-------EAPIYELTSQFTGLKCPSLAGKPKVFFIQ--A CQGDNY-QKGIPVE--TDS-EG-QPYLEMD------------------LSSPQTRYIPDE ADFLLGMATVN--N--CVSYRNPAEGTWYIQSLCQSLKE-------RCP-RGDDIL---- -------TILTEVNYEVSNKD---D-------KKNMGKQMPQPTF-----TLRKKLVFPS D------------------ >P_troglodytes_ENSPTRP00000005216 --------------MDCVGWPPGRKWHLEKNTSCGGSSGICASYVTQMADDQGCIEEQGV EDSANEDSVDAK----PDRSSFVPSLFS-KKKKNVTM----------------------- RSIKTTRDRVP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------T-YQYNMNFE-KLGKCIIINNKNFD--KVT-------GM GVRNGTDKDAEAL-FKCFRSLGFDVIVYNDCSCAKMQDLLKKASEE-DHTNAACFACILL SHGEE-------NVIYGKDGV--------TPIKDLTAHFRGDRCKTLLEKPKLFFIQ--A CRGTEL-DDGIQAD--SGP-IN----------------------D---TDANPRYKIPVE ADFLFAYSTVP--G--YYSWRSPGRGSWFVQALCSILEE-------HG--KDLEIM---- -------QILTRVNDRVARHF---ESQ-SDDPRFHEKKQIPCVVS-----MLTKELYFSQ ------------------- >G_gallus_ENSGALP00000019870 ------------------------------------------------------------ ----------MS----GAERRPAAGRVQLDSKPTPTTTADG------------------N QNITEVDAFDK-R----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------QTFDPA-VQYKMNHQ-RRGVALIFNHEHFF--WHL-------RL PDRRGTLADRNNL-KRSLTDLGFEVRIFDDLKAEDVLKKVFEASRD-DYSNADCFVCVFL SHGEN-------DHVYAYDAQ--------IKIETITNMFRGDKCQSLVGKPKIFIIQ--A CRGDKH-DDPVLVQ--DSVDSK-D----------------ETTVNQTEVDAAGVYTLPAG ADFIMCYSVAQ--G--YFSHRETVNGSWYIQDLCEALGK-------HG--SSLEFT---- -------ELLTVVNRKVSHRK---VDI-CRDINAIGKKQIPCFAS-----MLTKKLYFHP K-SK--------------- >O_anatinus_ENSOANP00000005811 ------------------------------------------------------------ -------------------------PRGATRLARGHPAAGG------------------A PNVTEVDGFYD-R----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------ETFDPA-AKYKMEYK-RRGVALIFNHERFY--WQL-------KL PDRHGTRADRENL-IRRLSALGFEVKCFDDLKAEEVMLKIHQASSS-NHADADCFLCVFL SHGQG-------NHVYAYNGK--------IDIPEMTSMFKGDQCRSLVGKPKIFIFQ--A CRGEQH-DVGVVPL--DVVDSKIS----------------EQDVNETEVDAASVYTLPAG ADFLMCYSVAE--G--YYSHRETVNGSWYIQDLCEMLGR-------YG--SSLEFT---- -------ELLTLVNRKVSYRR---VDF-CKDPSLIGKKQVPCFAS-----MLTKKLHFLP K-AQ--------------- >P_troglodytes_ENSPTRP00000021879 MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKM DFSRNLYDIGEQ----LDSEDLASLKFLSLDYIPQRKQEPI------------------K DALMLFQRLQE-KR-MLEESNLSFLKELLFRINRLDL----------------------- ------------------------------------LITYLNTRKEEMERELQTPGRAQI SAY--------------------------------------------------------- -------RVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGE GKLDILKRV-------CAQINRSLLKIINDYE---------------------------- ------------------------------------------------------------ -------------------------------------------EFSKERSSSLE------ --------------------------------------GSPDEFSN-------GEELCGV MTISDSPREQDS----ESQTLD-KVYQMKSK-PRGYCLIINNHNFA--KAREKVPKLHSI RDRNGTHLDAGAL-TTTFEELHFEIKPHDDCTVQQIYEILKIYQLM-DHSNMDCFICCIL SHGDK-------GIIYGTDGQ-------EAPIYELTSQFTGLKCPSLAGKPKVFFIQ--A CQGDNY-QKGIPVE--TDS-EE-QPYLEMD------------------LSSPQTRYIPDE ADFLLGMATVN--N--CVSYRNPAEGTWYIQSLCQSLRE-------RCP-RGDDIL---- -------TILTEVNYEVSNKD---D-------KKNMGKQMPQPTF-----TLRKKLVFPS D------------------ >G_gallus_ENSGALP00000029853 ------------------------------------------------------------ ------------------GACGMQRYHQEALKKNRVMLARE------------------L VLKELMEHMIE-KD-IITIEMVEMIQAK----SGSFS------QNVE------------- ------------------------------------FLNLLPKRGPNA------------ ------------------------------------------------------------ -----------------------------------------------FSAFCEALQETKQ QHLAEMILK-------TESS--LR--------------HGIAT-------------LEQR YGSNLPL----PLSESCNSK--------------RPRLIVF------------------- --------------------------------------FCT-KPVEH------------- --------------------------------------------------SLDSGDGPPI --PPVKHCTPEF----YRDHQH-LAYKLISE-PRGLALILSNIHFS--SEK-------DL EYRSGGDVDCASL-ELLFKHLGYQVTVFHDQSAEEMESALERFSKLPDHQDVDSCIVALL SHGVE-------GGVYGTDGK-------LLQLQEAFRLFDNANCPNLQNKPKMFFIQ--A CRGDET-DRGVDQR--DGK-EWSDSPGCEESDANK--------------EENLKLRLPTR SDMICGYACLK--G--TAAMRNTKRGSWYIEALTTVFAE-------DS--RDTHVA---- -------DMLVKVNRQIKQRE---G--YAPGTEFHRCKEMSEYCS-----TLCRDLYLFP G-YVPGK------------ >R_norvegicus_ENSRNOP00000022693 -----------------------------------------------MTDDQDCAAELEM ADSSTEDGVDAK----PDRSTIISSLLW-KKKKNASM----------------------- CPVSTTRDRVP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------T-YLYRMDFE-KMGKCIIINNKNFD--KAT-------GM DVRNGTDKDAEAL-FKCFRSLGFEVTVYNDCSCAKMQDLLRRASEE-DHSNSACFACVLL SHGEE-------NLIYGKDGV--------TPIKDLTAHFRGDRCKTLLEKPKLFFIQ--A CRGTEL-DDGIQAD--SGP-IN----------------------D---TDANPRYKIPVE ADFLFAYSTVP--G--YYSWRNPGKGSWFVQALCSILNE-------HG--KDLEIM---- -------QILTRVNDRVARHF---ESQ-SDDPRFNEKKQIPCMVS-----MLTKELYFGR ------------------- >P_pygmaeus_ENSPPYP00000003106 --------------MDCVGWPPGRRWHLEKNTSCSGSSGICASYVTQMADDQGCVEEQGL GDSANEDSVDAK----PDRSSFVPFLFS-MKKKNVSM----------------------- QSIKTTRDRVP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------T-YQYNMNFE-KLGKCIIINNKNFD--KVT-------GM GVRNGTDKDAEAL-FKCFRSLGFDVIVYNDCSCAKMQDLLKKASEE-DHTNAACFACILL SHGEE-------NLIYGKDGV--------TPIKDLTAHFRGDRCKTLLEKPKLFFIQ--A CRGTEL-DDGIQAD--SGP-IN----------------------D---TDANPRYKIPVE ADFLFAYSTVP--G--YYSWRSPGRGSWFVQALCSILEE-------HG--KDLEIM---- -------QILTRVNDRVARHF---ESQ-SDDPRFHEKKQIPCVVS-----MLTKELYFSQ ------------------- >P_pygmaeus_ENSPPYP00000016744 ------------------------------------------------------------ --------------------------MSSVSGLRRGHPAGG------------------E ENMTETDAFYK-R----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------EMFDPA-EKYKMDHR-RRGIALIFNHERFF--WHL-------TL PERRGTCADRDNL-TRRFSDLGFEVKCFNDLKAEELLLKIHEVSTV-SHADADCFVCVFL SHGEG-------NHIYAYDAK--------IEIQTLTGLFKGDKCHSLVGKPKIFIIQ--A CRGNQH-DVPVIPL--DVVDNQTD----------------KLDTNITEVDAASVYTLPAG ADFLMCYSVAE--G--YYSHRETVNGSWYIQDLCEMLGK-------YG--SSLEFT---- -------ELLTLVNRKVSQRR---VDF-CKDPSAIGKKQVPCFAS-----MLTKKLHFFP K-SN--------------- >P_troglodytes_ENSPTRP00000028104 ------------------------------------------------------------ --------------------------MSSASGLRRGHPAGG------------------E ENMTETDAFYK-R----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------EMFDPA-EKYKMDHR-RRGIALIFNHERFF--WHL-------TL PERRGTCADRDNL-TRRFSDLGFEVKCFNDLKAEELLLKIHEASTV-SHADADCFVCVFL SHGEG-------NHIYAYDAK--------IEIQTLTGLFKGDKCHSLVGKPKIFIIQ--A CRGNQH-DVPVIPL--DVVDNQTE----------------KLDTNITEVDAASVYTLPAG ADFLMCYSVAE--G--YYSHRETVNGSWYIQDLCEMLGK-------YG--SSLEFT---- -------ELLTLVNRKVSQRR---VDF-CKDPSAIGKKQVPCFAS-----MLTKKLHFFP K-SN--------------- >M_mulatta_ENSMMUP00000001627 ------------------------------------------------------------ ---------------------------S-KKKKNVSG----------------------- QSIKTTRDRVP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------T-YQYNMNFE-KMGKCIIINNKNFD--KVT-------GM GVRNGTDKDAEAL-FKCFQSLGFDVIVHNDCSCAKMKDLLKKASEE-DHTNAACFACILL SHGEE-------NLIYGKDGV--------TPIKDLTAHFRGDRCKTLLEKPKLFFIQ--A CRGTEL-DDGIQAD--SGP-IN----------------------D---TDANPRYKIPVE ADFLFAYSTVP--G--YYSWRSPGRGSWFVQALCSILEE-------HG--KDLEIM---- -------QILTRVNDRVARHF---ESQ-SDDPCFHEKKQIPCVVS-----MLTKELYFSH ------------------- >M_mulatta_ENSMMUP00000037892 VEGGRRARVVTESKRNFFLGACPTPFPTEHVELGRLGGSETAMVPGKGGADYILLPFEEM DFNRNLYDIGEQ----LDSEELASLKFLSLDCIPQRKQEPI------------------K DALMLFQRLQE-KR-MLEENNLSFLKELLFRINRLDL----------------------- ------------------------------------LTTYLNTRKEEMERELQAPGRAQI SAY--------------------------------------------------------- -------RVMLYQISEEVGRSELRSFKFLLQEEISKCKLDDDMNLLDIFVEMEKRVILGE GKLDILKRV-------CAQVNKSLLKIINDYE---------------------------- ------------------------------------------------------------ -------------------------------------------EFSRERTRSLE------ --------------------------------------GSPEEGSN-------GEELCGL MTISDSPREQDS----ESQTLD-KVYQMKSK-PRGYCLIINNYDFT--KAREKVPKLHSI RDRNGTHLDAEAL-TATFEELHFEIQHHNDCTVEKIYKILKTYQLM-DHSNKDCFICCIL SHGDK-------GIIYGTDGQ-------EAPIYELTSQFTGLKCPSLAGKPKVFFIQ--A CQGDNY-QKGIPVE--TDS-EE-QPYLEMD------------------LSSPQTRYIPDE ADFLLGMATVN--N--CVSYRNPAEGTWYIQSLCQSLRE-------RCP-RGDDIL---- -------TILTEVNYEVSNKD---D-------KKNMGKQMPQPTF-----TLRKKLVFPS D------------------ >D_rerio_ENSDARP00000050929 ------------------------------------------------------------ ----------MA----SHTKSDGSAAVEKDSASAGQTV---------------------E ENLTETDSFNQ-SI---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------FSMDPN-QEYDMNHK-RRGMALIFNHENFF--WKL-------GL GYRSGTNADKENL-IRRFRELNFEVKAFDDYKRHEVLSKITEAAAA-DHVDADCFVCVFL SHGEN-------GHVYANDGQ--------IEIPEITDLFKGDKCRSLVGKPKIFIWQ--A CRGDKH-DDPVTPM--DVVDSQ--------------------VTNDMVVDAGVLYTLPAG ADFIMCYSVAE--G--YYSHRETVNGSWYIQDLCEILRR-------YG--SELEFA---- -------EILTLVNRKVSLRS---VLN-CKDRSAVGKKQVPCFAS-----MLTKKLFFRP K-K---------------- >G_gorilla_ENSGGOP00000000205 ---------------------------------------------------YILLPFEKM DFSRNLYDIGEQ----LDSEDLASLKFLSLDYIPQRKQEPI------------------K DALMLFQRLQE-KR-MLEESNLSFLKELLFRINRLDL----------------------- ------------------------------------LITYLNTRKEEMERELQTPGRAQI SAY--------------------------------------------------------- -------RVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMXLLDIFIEMEKRVILGE GKLDILKRV-------CAQINKSLLKIINDYE---------------------------- ------------------------------------------------------------ -------------------------------------------EFSKERSSSLE------ --------------------------------------GSPDEFSN-------GEELCGV MTISDSPREQDS----ESQTLD-KVYQMKSK-PRGYCLIINNHNFA--KAREKVPKLHSI RDRNGTHLDAGAL-TTTFEELHFEIKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCIL SHGDK-------GIIYGTDGQ-------EAPIYELTSQFTGLKCPSLAGKPKVFFIQ--A CQGDNY-QKGIPVE--TDS-EE-QPYLEMD------------------LSSPQTRYIPDE ADFLLGMATVN--N--CVSYRNPAEGTWYIQSLCQSLRE-------RCP-RGDDIL---- -------TILTEVNYEVSNKD---D-------KKNMG----------------------- ------------------- >P_pygmaeus_ENSPPYP00000020323 -----------------------------------------------MAAPTAGSWSTFE HKELMAADRGRR----ILGVCGMHPHHQETLKKNRVVLAKQ------------------L LLSELLEHLLE-KD-IITLEMRELIQAK----VGSFS------QNVE------------- ------------------------------------LLNLLPKRGPQA------------ ------------------------------------------------------------ -----------------------------------------------FDAFCEALRETKQ GHLEDMLLT-------TLSG--LQ--------------HVLPP-------------LSCD YDLSLPF----PVCESC-----------------PLYKKLR------------------- --------------------------------------LST-DTVEH------------- --------------------------------------------------SLDNKDGPVC --LQVKPCTPEF----YQTHFQ-LAYRLQSR-PRGLALVLSNVHFT--GEK-------EL EFRSGGDVDHSTL-VTLFKLLDYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALL SHGVE-------GAIYGVDGK-------LLQLQEVFQLFDNANCPSLQNKPKMFFIQ--A CRGDET-DRGVDQQ--DGK-NHAGSPGCEESDAGK--------------EKLPKMRLPTR SDMICGYACLK--G--TAAMRNTKRGSWYIEALAQVFSE-------RA--CDMHVA---- -------DMLVKVNALIKDRE---G--YAPGTEFHRCKEMSEYCS-----TLCRHLYLFP G-HPPT------------- >D_rerio_ENSDARP00000083664 ------------------------------------------------------------ ----------------MLGECGMTKWERLALRRNSVKMLQD------------------L VVDDLLIQCLQ-QDGILTDSMAESIMAK----PTSQG------RSHQ------------- ------------------------------------LLFLLPKRGPRA------------ ------------------------------------------------------------ -----------------------------------------------FSTFCSALKETEQ HHLCKLLMD-------FTEKDKKNSQYK-------------------------------- -----------LSPEICKKKNKH------------------------------------- --------------------------------------THTHKSMEM------------- --------------------------------------------------CLD-ADSPVT --TAVLPCTPEF----YQSHRP-QAYPMRSC-PRGLALVLSNVRFD-SANT-------DL DIRRGGEVDEETL-RRLFTELDFKVSLHRDLTAEAMRRCLEQFAQQQEHAAYDCAVVCLL SHGVE-------GSVYGTDGQ-------LLELDWVFEVFDNARCPLLQNKPKMFFIQ--A CRGEEM-DNGVDQL--DGQ-ERTQSPGCEQRDAGREGERDNREKKEEKERERLRVKLPQR SDMICGFATLK--G--TAAMRNTKKGSWFIQELNTAIRQ-------RA--NNTHLS---- -------DILVQVNGQIKSRE---G--YAPGSAHHRCKEMSEFTS-----SLCKDLYLFP K-YYPSN------------ >D_rerio_ENSDARP00000006831 ------------------------------------------------------------ ---MNGDCVDAKRVDTTDASKDGASAS--------------------------------Q PMQVDAKPQSH------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------A-FRYSLNYP-NIGHCIIINNKNFD--RRT-------GM NPRNGTDVDAGNV-MNVFRKLGYIVKVYNDQTVAQIMQVLTTVAHD-DHSRCASLVCVLL SHGDE-------GVFFGTDTS--------VDLKSLTSLFRGDRCPSLVGKPKLFFIQ--A CRGTEL-DPGVETD--HPD-HP--------------------------DIPDGRVRIPVE ADFLYAYSTVP--G--YYSWRNTMTGSWFIQSLCEMMTK-------YG--SELELL---- -------QIMTRVNHKVALDF---EST-SNMPGFDAKKQIPCIVS-----MLTKEMYFTP ------------------- >O_cuniculus_ENSOCUP00000009498 -----------------------------------------------MADDQAHAGELGA GDSESADAVDAK----PDRSSFVPALFS-KKKKNGPK----------------------- QSAKATRDQVP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------S-YQYNMNFD-KMGKCIIINNKNFD--KVT-------GM GVRNGTDKDAEAL-FKCFRSLGFDVMVYNDCSCARMQDLLKRASEE-DHTNSACFACILL SHGEE-------NLIYGKDGV--------IPIKDLTAHFRGDRCKTLLEKPKLFFIQ--A CRGTEL-DDGIQAD--SGP-IN----------------------D---TDANPRHKIPVE ADFLFAYSTVP--G--YYSWKNPGRGSWFVQALCSILDE-------HG--KELEVM---- -------QILTRVNDRVARHF---ESQ-SDDPRFNEKKQIPCVVS-----MLTKELYFCR ------------------- >H_sapiens_ENSP00000312664 -----------------------------------------------MAAPSAGSWSTFQ HKELMAADRGRR----ILGVCGMHPHHQETLKKNRVVLAKQ------------------L LLSELLEHLLE-KD-IITLEMRELIQAK----VGSFS------QNVE------------- ------------------------------------LLNLLPKRGPQA------------ ------------------------------------------------------------ -----------------------------------------------FDAFCEALRETKQ GHLEDMLLT-------TLSG--LQ--------------HVLPP-------------LSCD YDLSLPF----PVCESC-----------------PLYKKLR------------------- --------------------------------------LST-DTVEH------------- --------------------------------------------------SLDNKDGPVC --LQVKPCTPEF----YQTHFQ-LAYRLQSR-PRGLALVLSNVHFT--GEK-------EL EFRSGGDVDHSTL-VTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALL SHGVE-------GAIYGVDGK-------LLQLQEVFQLFDNANCPSLQNKPKMFFIQ--A CRGDET-DRGVDQQ--DGK-NHAGSPGCEESDAGK--------------EKLPKMRLPTR SDMICGYACLK--G--TAAMRNTKRGSWYIEALAQVFSE-------RA--CDMHVA---- -------DMLVKVNALIKDRE---G--YAPGTEFHRCKEMSEYCS-----TLCRHLYLFP G-HPPT------------- >P_troglodytes_ENSPTRP00000033921 -----------------------------------------------MAAPSAGSWSTFQ HKELMAADRGRR----ILGVCGMHPHHQETLKKNRVVLAKQ------------------L LLSELLEHLLE-KD-IITLEMRELIQAK----VGSFS------QNVE------------- ------------------------------------LLNLLPKRGPQA------------ ------------------------------------------------------------ -----------------------------------------------FDAFCEALRETKQ GHLEDMLLT-------TLSG--LQ--------------HVLPP-------------LSCD YDLSLPF----PVCESC-----------------PLYKKLR------------------- --------------------------------------LST-DTVEH------------- --------------------------------------------------SLDNKDGPVC --LQVKPCTPEF----YQTHFQ-LAYRLQSR-PRGLALVLSNVHFT--GEK-------EL EFRSGGDVDHSTL-VTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALL SHGVE-------GAIYGVDGK-------LLQLQEVFQLFDNANCPSLQNKPKMFFIQ--A CRGDET-DRGVDQQ--DGK-NHAGSPGCEESDAGK--------------EKLPKMRLPTR SDMICGYACLK--G--TAAMRNTKRGSWYIEALAQVFSE-------RA--CDMHVA---- -------DMLVKVNALIKDRE---G--YAPGTEFHRCKEMSEYCS-----TLCRHLYLFP G-HPPT------------- >M_musculus_ENSMUSP00000027189 -----------------------------------------------------------M DFQSCLYAIAEE----LGSEDLAALKFLCLDYIPHKKQETI------------------E DAQKLFLRLRE-KG-MLEEGNLSFLKELLFHISRWDL----------------------- ------------------------------------LVNFLDCNREEMVRELRDPDNAQI SPY--------------------------------------------------------- -------RVMLFKLSEEVSELELRSFKFLLNNEIPKCKLEDDLSLLEIFVEMEKRTMLAE NNLETLKSI-------CDQVNKSLLGKIEDYE---------------------------- ------------------------------------------------------------ -------------------------------------------RSSTERRMSLE------ -------------------------------------------GREELPPSVLDEMSLKM AELCDSPREQDS----ESRTSD-KVYQMKNK-PRGYCLIINNHDFS--KAREDITQLRKM KDRKGTDCDKEAL-SKTFKELHFEIVSYDDCTANEIHEILEGYQSA-DHKNKDCFICCIL SHGDK-------GVVYGTDGK-------EASIYDLTSYFTGSKCPSLSGKPKIFFIQ--A CQGSNF-QKGVPDE--AGF-EQQNHTLEVD-------------------SSSHKNYIPDE ADFLLGMATVK--N--CVSYRDPVNGTWYIQSLCQSLRE-------RCP-QGDDIL---- -------SILTGVNYDVSNKD---D-------RRNKGKQMPQPTF-----TLRKKLFFPP ------------------- >M_musculus_ENSMUSP00000030747 ------------------------------------------------------------ ----------------------MDEADRQLLRRCRVRLVSE------------------L QVAELWDALLS-RE-LFTRDMIEDIQQAGSG--SRRD------QARQ------------- ------------------------------------LVTDLETRGRQA------------ ------------------------------------------------------------ -----------------------------------------------LPLFISCLEDTGQ GTLASLLQS--------------------------------------------------- ------------------------------------------------------------ -------------------------------------GRQAAKQDPEAVKPLDHLVPVVL GPMGLTAKEQRVVK---LDPSQPAVGNLTPVVLGPEELWPARLKPEVLR-PETPRPVDIG SGGAHDVCVPGK----IRGHAD-MAYTLDSD-PCGHCLIINNVNFC--PSS-------GL GTRTGSNLDRDKL-EHRFRWLRFMVEVKNDLTAKKMVTALMEMAHR-NHRALDCFVVVIL SHGCQASHLQFPGAVYGTDGC-------SVSIEKIVNIFNGSGCPSLGGKPKLFFIQ--A CGGEQK-DHGFEVA--CTS-SQGRTLDSDSEPDAVPYQEGPRPL----DQLDAVSSLPTP SDILVSYSTFP--G--FVSWRDKKSGSWYIETLDGILEQ-------WA--RSEDLQ---- -------SLLLRVANAVSAKG--------------TYKQIPGCFN-----FLRKKLFFKT S------------------ >O_anatinus_ENSOANP00000000517 ------------------------------------------------------------ -AASGEVMVDSK----SFHSSQGYSSRK-------------------------------V PGKQFLGSSAS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------LD-DRYRMDYP-NMGICLIINNKNFH--PDT-------RM GCRSGTDVDAASL-RDTFKKLKYEVRCKNDLKRREILELLTSVAHE-DHSKRSSFVCVLL SHGEE-------GVIFGTDGS--------LELKSLASLFRGDNCRSLVGKPKLFIVQ--A CRGTEL-DSGVEAD--SSS-AD----------------------------DGSEQKIPVE ADFLYAYSTAP--G--YYSWRNSMNGSWFIQALCAMLKQ-------HA--HTLELL---- -------HILTRVNRKVATEF---ESY-SLDATFNAKKQIPCIVS-----MLTKELYFPY ------------------- >E_caballus_ENSECAP00000021726 ------------------------------------------MTSQGQNLNSSSDDNCTM DFRQKLLFIDSH----LGDQDVERLRFLCRDCVSHKKLEKS------------------S SALEIFNHLLA-ED-LLREEDSFFLAELLYIIKQKS------------------------ ------------------------------------LLCHLCYTKEQVESLL--PARRRV SLF--------------------------------------------------------- -------RNLLYELSEGMDSDNLNSMMFLLKDSIPKTQM----TSLSLLAHLEKQARIDE DNLTLLEML-------CKNVVPNLMRKIEKYK---------------------------- ------------------------------------------------------------ -------------------------------------------REKAA---QVVTAPVDK ETESLHHGEEELFSR--SDIKKFSRALPQ-------PWEHTHAGLGSLPLGN-SRVSKGW SSALASGIGSIS-----SSKET-PLYRMDRT-HRGHCVVVNNHTFT------------SL ADRPGTDKDAECL-KSVFQWLGFSVHRYDNVTKEGLEKVLQEYRNHPGHASGDCFVFCVL THGKF-------GAVYSSDGI-------LIPIREIMSHFTAQRCPALAHKPKLFFIQ--A CQGEEV-QPSVSIE--ADA-VNPE-----------------------NVTPSLEDSVPVE ADFLLGLATVP--G--YVSFRHVKEGSWYIQSLYNNLKD-------LVP-RREDIL---- -------SILTAVNDDVSRQV---D-------IYGKKKQMPQPAF-----TLRKKLVFPV P------------------ >M_musculus_ENSMUSP00000026062 -----------------------------------------------MTDDQDCAAELEK VDSSSEDGVDAK----PDRSSIISSILL-KKKRNASA----------------------- GPVRTGRDRVP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------T-YLYRMDFQ-KMGKCIIINNKNFD--KAT-------GM DVRNGTDKDAGAL-FKCFQNLGFEVTVHNDCSCAKMQDLLRKASEE-DHSNSACFACVLL SHGEE-------DLIYGKDGV--------TPIKDLTAHFRGDRCKTLLEKPKLFFIQ--A CRGTEL-DDGIQAD--SGP-IN----------------------D---IDANPRNKIPVE ADFLFAYSTVP--G--YYSWRNPGKGSWFVQALCSILNE-------HG--KDLEIM---- -------QILTRVNDRVARHF---ESQ-SDDPRFNEKKQIPCMVS-----MLTKELYFSR ------------------- >E_caballus_ENSECAP00000013731 -----------------------------------------------MADDQDCVVEQGA GDSTSTDAVDAK----PDRSSFVPSLFS-KKKKNGPE----------------------- RSITTNRNREP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------T-YQYNMNFE-KVGKCVIINNKNFD--RGT-------GM GVRNGTDKDAEAL-FKCFRNLGFDVVVYNDCSCAKMKSLLKQASEE-DHRNSACFACILL SHGEE-------NLIYGTDGM--------TPIKDLTGHFRGDRCKTLLEKPKLFFIQ--A CRGTEL-DDGIQAD--SGP-IND---------------------D---TDANPRYKVPVE ADFLFAYSTVP--G--YYSWRNPGSGSWFVQALCSILNE-------HG--KSLEII---- -------QILTRVNHRVARHF---ESH-SDDPRFHQKKQIPCVVS-----MLTKELYF-- ------------------- >G_gallus_ENSGALP00000002083 ------------------------------------------------------------ ----------------------MEEAQRSALRRGRVRLVEG------------------L RPEVLWGPLQA-RG-VFTSAMVEDMQSTG----TRRE------QARQ------------- ------------------------------------LVIDLETRGKQA------------ ------------------------------------------------------------ -----------------------------------------------FPIFLSILRDTGH GDLADMLDE--------------------------------------------------- ------------------------------------------------------------ -------------------------------------GCGSPMSPPV--DLRPVQLELPG ERRD-----------------------------------KSVSTAERLSIPVQPESERFR MPPAPAQACPTG----LAGECS-EVYQLRAD-PCGHCLIFNNVSFS--RDS-------DL STRAGSDIDCEKL-EKRFRSLCFHVRTLRNLKAQEIDVELRKLARL-DHSALDCCLVVIL SHGCQTSHIQFPGGIYGTDGK-------IIPIERIVNYFNGSQCPSLRGKPKLFFIQ--A CGGEQK-DQGFEVD--CES-PQDETCRRSIESDAIPFQAPSGNE----DEPDAVASLPTP GDILVSYSTFP--G--FVSWRDKVSGSWYVETLDSVLEH-------YA--RSEDLL---- -------TMLLRVSDIVSTKG--------------RYKQIPGCFN-----FLRKKFFFLC K------------------ >B_taurus_ENSBTAP00000003205 ------------------------------------------------------------ ----------------------MNEADRLLLRRYRVRLVGE------------------L QVASLWDALLS-RE-LFTPDMIEDIQRAGSG--SRRD------QARQ------------- ------------------------------------LILDLETRGSQA------------ ------------------------------------------------------------ -----------------------------------------------LPLFISCLEDTGQ DTLASLLKT--------------------------------------------------- ------------------------------------------------------------ -------------------------------------SRQAAKQ---------------- --------------------SKPSQGKLAPVVLGPEELWPAKLRPEVLR-PEVPRAVDAG SGGFTDVCPQDR----AKGNAD-LAYVLNAD-PCGHCLIINNVNFC--RES-------GL RARTGSNIDCERM-RQRFHLLQFVVEVKCDLTAKQMVQALMQLARQ-DHSALDCCVVVIL SHGCQASHLQFPGAVYGTDGC-------PVSVERIVNTFNGTGCPSLRGKPKLFFIQ--A CGGEQK-DHGFEVE--STS-PEDKTPSSDPEADATPFQEGPRSI----DEPDAVSSLPTP SDILVSYSTFP--G--FVSWRDPKSGSWYIETLDSIFEQ-------WA--HCEDLQ---- -------TLLLRVANAVSVKG--------------IYKQMPGCFN-----FLRKKLFFKT ------------------- >R_norvegicus_ENSRNOP00000017972 ------------------------------------------------------------ ----------------------MEEADRQLLRRCRVRLVRE------------------L QVAELWDALLS-RE-LFTRDMIEDIQRAGSG--SRRD------QARQ------------- ------------------------------------LVIDLETRGRQA------------ ------------------------------------------------------------ -----------------------------------------------LPRFISCLEDTGQ GSLASFLQS--------------------------------------------------- ------------------------------------------------------------ -------------------------------------SGQAAKQDPEAVTPLDHLVPVVL GPMGLKSKEQKVVK---LDPSQPALGNLTPVVLGPEELWPTRLRPEVLT-PETPRPVDIG SGRAHDVCTPGK----IERHAD-MAYTLDSD-PCGHCLIINNVNFC--PSS-------GL STRIGSHVDCEKL-QHRFCWLRFMVEVKNDLTAKKMVTALMEMAHR-DHRALDCFVVVIL SHGCQASHLQFPGAVYGTDGC-------SVSIERIVNIFNGTGCPSLGGKPKLFFIQ--A CGGEQK-DHGFEVA--FTS-SQDKAFDSDSEPDAVPYQEGPRTL----DQLDAVSSLPTP SDILVSYSTFP--G--FVSWRDKKSGSWYIETLDGVLEQ-------WA--RSEDLQ---- -------SLLLRVANAVSEKG--------------VYKQIPGCFN-----FLRKKLFFKL H------------------ >M_domestica_ENSMODP00000005556 ------------------------------------------------------------ -MEDTGTTVDAK----STKNSGVKL----------------------------------F HGSKSVESGLS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------S-DSYKMDYP-EMGLCIIINNKNFH--PNT-------GM SFRSGTDVDAASL-SDTFRSLKYEVRIKNDLTCNEITELLNSVSKE-DHSQRSSFICVIL SHGEE-------GVIFGTDRS--------VELKRLTCFFRGDKCRSLTGKPKLFIIQ--A CRGTEL-DCGVETD--SGT-DE----------------------------DIACQKIPVE ADFLYAYSTAP--G--YYSWRNSKDGSWFIQALCAVLKQ-------HA--HKLEIM---- -------QILTRVNRKVATEF---ESY-SLDISFHAKKQVPCIMS-----MLTKELYFSH ------------------- >M_domestica_ENSMODP00000036247 -----------------------------------------------------------M DFHTFLYGIAEE----IDSADLASLKFLCLDQIPLKKQQHI------------------K DALVLFQTLEE-RG-LLEEDNLFFLKELLFRINRIDL----------------------- ------------------------------------LNEPLNTKGPEMERELQVPNKARI SPY----------------------------RLHLHTTIWPFRDNWTCRITLSVSFTSRT KQLLSVMVILLFNLSEGVGPSELKSIKFMLSSKIPKCKIEDDMTLMDLFIEMEKRGILGE GNLDALKIV-------CDQIDKSLLKKIQEYE---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------ISKGRNNLFL IYQNTQPQEVYD----SAGEKG-NVYKMSSR-PRGYCLIINNFDFK--ISRKERPENHYL TDRRGTNKDEEAL-KNIFKELHFDIQSFQDLTAEGIQQVLKTFKDN-NHESKDCFVCCLL SHGNK-------GTIYGIDGK-------EVPIRDLTSYFSGSNCPSLAGKPKVFFIQ--A CQGKAT-QYGISLD--TDS-EQQRESLEAD-------------------KSFQSECIPNE ADFLLGMATVE--N--YVSYRDSARGTWYIQSLCKNLKE-------GCL-RGNDIL---- -------TILTEVNSEVSQKT---D-------PKNNGKQMPQPKI-----TLRKKLVFPI S------------------ >B_taurus_ENSBTAP00000038128 -----------------------------------------------------------M ALTQCLYNIGEQ----LGSDDLAALKFLSRDHIPYRKQEPI------------------K DALMLFQRLQE-KR-MLEENNLSFLKELLFRVNRLDL----------------------- ------------------------------------LLNYLYTSEEEMKRELQIPGRAQI SAY--------------------------------------------------------- -------RILLFQISEDVNKVELKDFKFFLSQEIAKCKLDDDMTLLDIFVEMEKRTILGE ENLDTLKRI-------CEQVNKSLLKKIYDYE---------------------------- ------------------------------------------------------------ -------------------------------------------ELRKERRMSLE------ --------------------------------------RDPYAFSNDMSQSLPEEGYSKM PAMSDSP-EQDS----ELQTSD-TVYRMTSK-PRGYCLIFNNYDFS--IARKQVPELHDL KDRTGTDFDADAL-DKTFRELHFEIVHYKDLTAKGICEVLESYQKK-DHKNKDCFICCIL THGNK-------GIIYGSDGQ-------EASIYELTSYFTGLKCPSLIGKPKIFFIQ--A CQGDKY-QKGVAVE--TDS-EQMEAYLEVD-------------------SSPQKRYIPDE ADFLLGMATVK--N--YVSYRNIWNGAWYIQSLCQNLRE-------RCP-RGEDIL---- -------TILTKVNFEVSKLD---D-------KQRMAKQMPQPTF-----TLRKKLFFPL N------------------ >T_guttata_ENSTGUP00000013612 ------------------------------------------------------------ ----------------MLAACGMQRCHQEALKKNRVMLAKQ------------------L VLNVLVEHMVE-KD-IIPTEMVEMIQAK----SGSFD------RNVE------------- ------------------------------------FLNLLPKRGPNA------------ ------------------------------------------------------------ -----------------------------------------------FSAFCEALRETQQ QHLETLILK-------TMSS--LS--------------QEIAR-------------LEHC HESDLPY----PASESCNSK--------------RPRWL--------------------- ------------------------------------------EPMEH------------- --------------------------------------------------SLDNRDGPSI --PPVKYCTPEF----YHNHQH-LAYKLTSE-PRGLALILSNVRFS--SEK-------DL EYRAGGDVDCASL-EMLFRHLGYRVTVFCDQTAQDMQNALERFSKLQDHRDVDSCIIALL SHGVE-------GGVYGSDGK-------LLELQETFRLFDNANCPNLQNKPKMFFIQ--A CRGDEL-DRGVDQR--DGK-GRSDSPGCEESDANK--------------EESLKLRLPTC SDMICGYACLK--G--TAAMRNTKRGSWYVEALTSVFAE-------DS--QHTHVA---- -------DMLVKVNRQIKQRE---G--YAPGTEYHRCKEMSEYCS-----TLCRDLYLFP G-YLPGK------------ >B_taurus_ENSBTAP00000008706 ------------------------------------------------------------ ---------------------------S-KKKKNDSG----------------------- KSVNIPRDRVP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------T-YQYNMNFE-KVGKCIIINNKNFD--RIT-------GM GVRNGTDKDAEAL-FKCFRSLGFDVSVYNDCSCAKMQDLLKKASEE-DHRNSACFACILL SHGEE-------NLIYGTDGK--------TAIKDLTAHFRGDRCKTLLEKPKLFFIQ--A CRGTEL-DDGIQAD--SGP-IN----------------------D---TDANPRYKIPVE ADFLFAYSTVP--G--YYSWRNPGSGSWFVQALCSILNE-------HG--KSLEIL---- -------QILTRVNDRVARHF---ESQ-SDDPRFHEKKQIPCVVS-----MLTKELYF-- ------------------- >O_anatinus_ENSOANP00000005545 ------------------------------------------------------------ ----------------------MQPCHQEALKKNRVALAKQ------------------L MLSELLEHLLE-KD-VITMEMRELIQAK----AGSFS------QNVE------------- ------------------------------------FLNLLPKRGPKA------------ ------------------------------------------------------------ -----------------------------------------------FDAFCAALRETKQ GHLQDLLYR-------TLSN--LSPPSTAVGALGTQGEELAGR-------------LGGR WRGLPSL----PSVSVCPVVVCPFLMVLGNSRLQPALSVGD------------------- --------------------------------------LLP-EEMEH------------- --------------------------------------------------SLDNGDGPPC --PQVKPCTPEF----YRVHHH-LAYRLESR-PRGLALVLSNMRFN--GEK-------DL EFRSGGDVDHNAL-ITLFKHLDYSVEFLRDQTAQEMQEKLHNFAQSPRHRFTDSCVVALL SHGVE-------GGIYGVDGK-------LLQLQEVFRLFDNANCPSLQNKPKMFFIQ--A CRGDET-DRGVDQR--DGK-ERAASPGCEESDAGK--------------EEMLKVRLPTR SDMICGYACLK--G--TAAMRNTKRGSWYIEALTQVFAE-------SA--RDMHVA---- -------DMLVKVS---------------------------------------------- ------------------- >C_intestinalis_ENSCINP00000024485 ------------------------------------------------------------ EFRLLLHQICEG----LTGENVSMMKFLCKDAIPRSRELET------------------- -ALDFMEYFEA-KG-WIQEGDLGFLAEVLYRINRHD------------------------ ------------------------------------LLKLLPGVKNRR------------ ---------------------------------------------------DYEENFQAQ QNNFTTYRVVCFMLADELTEGDLKILKRLCAGKMSKANVRRSVDVLSWLTCMEEEDLLSE GDLDFIMSI-------L------------------------------------------- ------------------------------------------------------------ ----------------------------------------QHLDNQKPYKLFQRVRMNDN TVTLPKNQQKSNAFQ--PNSHLPVASGFNSLSKQEYNHTSKLEPQYVSMENHRAFNGGYN QYNNYQSEIKDT----STMGIL-DKYPME---RRGYCLIINNENFE-------------R QDRTGSGNDTERL-ENLFKEFGFILDVRKDLDQREMEKVIQEYTKK-DHSDKDCFVCVVM SHGLS-------GCVYGVDGL-------SLSTSKISKSFRPGMCSSLTGKPKIFFFQ--A CQGDRT-MDGHSAP--VDD-VESD-----------------------GAASHGRQVLPSE SDFLIGHSTVP--G--YLSYRSRTDGSWFISTLVDSLEK-------YH--EKEDLL---- -------SIMINVNQEMASKP---Y------------KQMPMPIA-----TLRKKVFFSK Q-NSNSSSNQN---CNTP- >H_sapiens_ENSP00000365051 -------------------------------------------RGGRPWGGGGSWGLGRA AEARKRTEAAWS----LSWLLAMDEADRRLLRRCRLRLVEE------------------L QVDQLWDALLS-RE-LFRPHMIEDIQRAGSG--SRRD------QARQ------------- ------------------------------------LIIDLETRGSQA------------ ------------------------------------------------------------ -----------------------------------------------LPLFISCLEDTGQ DMLASFLRT--------------------------------------------------- ------------------------------------------------------------ -------------------------------------NRQAAKL---------------- --------------------SKPTLENLTPVVL-----RPEIRKPEVLR-PETPRPVDIG SGGFGDVGALES----LRGNAD-LAYILSME-PCGHCLIINNVNFC--RES-------GL RTRTGSNIDCEKL-RRRFSSLHFMVEVKGDLTAKKMVLALLELAQQ-DHGALDCCVVVIL SHGCQASHLQFPGAVYGTDGC-------PVSVEKIVNIFNGTSCPSLGGKPKLFFIQ--A CGGEQK-DHGFEVA--STS-PEDESPGSNPEPDATPFQEGLRTF----DQLDAISSLPTP SDIFVSYSTFP--G--FVSWRDPKSGSWYVETLDDIFEQ-------WA--HSEDLQ---- -------SLLLRVSAAFLCKG--------------EGRLLRGSVSSWGWGFGVSRAGPNQ G------------------ >P_troglodytes_ENSPTRP00000056642 -------------------------------------------RGGRPWGGGGSWGLGRA AEARKRTEAAWS----LSWLLAMDEADRRLLRRCRLRLVEE------------------L QVDQLWDALLS-RE-LFRPHMIEDIQRAGSG--SRRD------QARQ------------- ------------------------------------LIIDLETRGSQA------------ ------------------------------------------------------------ -----------------------------------------------LPLFISCLEDTGQ DMLASFLRT--------------------------------------------------- ------------------------------------------------------------ -------------------------------------NRQAAKL---------------- --------------------SKPTLENLTPVVL-----RPEIRKPEVLR-PETPRPVDIG SGGFGDVGALES----LRGNAD-LAYILSME-PCGHCLIINNVNFC--RES-------GL RTRTGSNIDCEKL-RRRFSSLHFMVEVKGDLTAKEMVLALLELARQ-DHGALDCCVVVIL SHGCQASHLQFPGAVYGTDGC-------PVSVEKIVNIFNGTSCPSLGGKPKLFFIQ--A CGGEQK-DHGFEVA--STS-PEDESPGSNPEPDATPFQEGLRTF----DQLDAISSLPTP SDIFVSYSTFP--G--FVSWRDPKSGSWYVETLDDIFEQ-------WA--HSEDLQ---- -------SLLLRVSAAFLCKG--------------EGRLLRGSVSSWGWGFGVSRAGPNQ G------------------ >B_taurus_ENSBTAP00000016642 ------------------------------------------------------------ --------------------------MSSEPPPRRARGPGE------------------E QNMTEIDAFPR-R----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------EIFDPT-EKYKMDHK-RRGIALIFNHERFF--WHL-------TL PNRPGTSADRDNL-RRRFSDLGFEVKCFDDLRAEELLLKIHEASTA-SHVDADCFLCVFL SHGEG-------NHIYAYDAK--------IEIQTLTGLFKGDKCQSLVGKPKIFIIQ--A CRGSQH-DVPVIPL--DVVDHRTD----------------TPDANLTQVDAASVYTLPAG ADFLMCYSVAE--G--YYSHRETVNGSWYIQDLCEMLGK-------FG--SSLEFT---- -------ELLTLVNRKVSQRR---VDF-CRDPNAIGKKQVPCFAS-----MLTKKLHFSP K-SK--------------- >A_gambiae_AGAP004920-PA ------------------------------------------------------------ -----------------------------------------------------------V CGRDILHCKTM------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------NTSTLSTAFDEVDNNTRVLS LVASVPEIISSSVIHELEPVDD-AHYNMSHN-RRGVAAVFNHRKFL------------HA SERKGTDADCDNI-RQVLIYLQFEVRVYDDLTRKEIKQVLDDLAEE-DHKNSDCLLVVIM THGDD-------DVLHAKDGT--------FNVDRLWENFIGDSCPSLLGKPKLFFIQ--A CRGSSF-DTGVHFS--QCM-TQVAKTVVPYAMRELPQPSIVPGC----PKSSIQYAIPSM ADLLVMYSTYK--G--HYSWRNPSTGSWFIRALCDELRE-------HG--NSKELL---- -------QLLTSVSRRVAYEF---QSNVPNNSQIDCQKQMPCIVS-----MLTRRIYFSK K------------------ >R_norvegicus_ENSRNOP00000022672 -----------------------------------------------MAASSGRSQSSLH RKGLMAADRRSR----ILAVCGMHPDHQETLKKNRVVLAKQ------------------L LLSELLEHLLE-KD-IITLEMRELIQAK----GGSFS------QNVE------------- ------------------------------------LLNLLPKRGPQA------------ ------------------------------------------------------------ -----------------------------------------------FDAFCEALRETRQ GHLEDLLLT-------TLSD--IQ--------------HILPP-------------LSCD YDSSLPF----SVCESC-----------------PPHKQSR------------------- --------------------------------------LST-DTMEH------------- --------------------------------------------------SLDNGDGPPC --LQVKPCTPEF----YQAHYQ-LAYRLQSQ-PRGLALVMSNVHFT--GEK-------DL EFRSGGDVDHTTL-VTLFKLLGYNVHVLYDQTAQEMQEKLQNFAQLPAHRVTDSCIVALL SHGVE-------GGIYGVDGK-------LLQLQEVFRLFDNANCPSLQNKPKMFFIQ--A CRGDET-DRGVDQQ--DGK-NHAQSPGCEESDAGK--------------EELMKMRLPTR SDMICGYACLK--G--NAAMRNTKRGSWYIEALTQVFSE-------RA--CDMHVA---- -------DMLVKVNALIKERE---G--YAPGTEFHRCKEMSEYCS-----TLCQQLYLFP G-YPPT------------- >C_familiaris_ENSCAFP00000016420 -----------------------------------------------MADDQDCGMEQAA GDSESPDAVDAR----PDRSSFVPSLFS-RKKKNDSG----------------------- RSIKTAQDQVP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------T-YQYNMNFE-KVGKCIIINNKNFD--KTT-------GM GVRNGTDKDAEAL-FKCFRNLGFDVVIYNDCSCAKMQDLLKKASEE-DHRNSACFACILL SHGEE-------NLIYGTDGM--------TAIKDLTAHFRGDRCRTLLEKPKLFFIQ--A CRGTEL-DDGVQAD--SGP-IN----------------------D---TDANPRYKIPVE ADFLFAYSTVP--G--YYSWRSPGSGSWFVQALCSTLNE-------HG--KSLEIL---- -------HILTRVNNRVARHF---ESQ-SDDPHFHEKKQIPCVVS-----MLTKELYF-- ------------------- >P_pygmaeus_ENSPPYP00000002138 ------------------------------------------------------------ ----------------------MDEADRRLLWRCRLRLVEE------------------L QVDQLWDALLS-RE-LFRPHMIEDIQRAGSG--SRRD------QARQ------------- ------------------------------------LIIDLETRGSQA------------ ------------------------------------------------------------ -----------------------------------------------LPLFISCLEDTGQ DMLASFLRT--------------------------------------------------- ------------------------------------------------------------ -------------------------------------NRQAAKL---------------- --------------------SKPTLENLTPVVLRPEIVRPEIRKPEVLR-PETPRPVDIG SGGFGDVGALES----MRGNAD-LAYILSMD-PCGHCLIINNVNFC--RES-------GL RTRTGSNIDSEKL-RRRFSSLHFMVEVKGDLTAKEMVLALLELAQQ-DHGALDCCVVVIL SHGCQASHLQFPGAVYGTDGC-------PVSVEKIVNIFNGTSCPSLGGKPKLFFIQ--A CGGEQK-DHGFEVA--STS-PEDESPGSNPEPDATPFQEGLRTF----DQLDAISSLPTP SDIFVSYSTFP--G--FVSWRDPKSGSWYVETLDDIFEQ-------WA--HSEDLQ---- -------SLLLRVANAVSVKG--------------IYKQMPGCFN-----FLRKKLFFKT S------------------ >T_rubripes_ENSTRUP00000037606 ------------------------------------------------------------ ----------RS----KMLHCGMREQDARTLRRQSAVLCKQ------------------L VVDELLIQCLQ-ADDILTESMAESIMAE----QTSQK------RSWR------------- ------------------------------------LQLLLPKRGPKA------------ ------------------------------------------------------------ -----------------------------------------------FSSFCSALRATDQ QHLCDLLTQ-------TFETNGNGTH------------------------------VETC VDSSVPL----PTQEAV-----------------PGVCVCV------------------- --------------------------------------CET-ESLEV------------- --------------------------------------------------SLD-ADSPIN --TPVLPCTPDF----YLSHFQ-QSYKMASS-PRGFALVISNVTFNPCAAP-------EL DPRKGGEVDDEVL-RKVFTELEYSVTVQRDLTAQGIKTCIQNFSGRPEHRSVDSCVVCLL SHGVE-------GAVYGIDGE-------LLQLDWVFEAFDNAHCPLLQNKPKMFFIQ--A CRGDEM-DCGVEQI--DGP-SRTSSPSCEQRDAGRE--------------GRPRIKLPQR SDMICGFASLK--GQDSSHAEHQKRGSWFIQELNTALRL-------HA--RDRHLA---- -------DILVQVNRRIKDRE---G--YAPGTAHHRCKEMSEFTS-----SLCKDLFLFP K-YQPQ------------- >E_caballus_ENSECAP00000015102 ------------------------------------------------------------ ----------------------MNEADRQLLRRSRLRLVRE------------------L QVDSLWDALLT-RE-LFTPDMIEDIQR--SG--SRRD------QARQ------------- ------------------------------------LIIDLETRGSQA------------ ------------------------------------------------------------ -----------------------------------------------LLLFISCLEDTGQ DTLASFLRT--------------------------------------------------- ------------------------------------------------------------ -------------------------------------SSQAAKQNPEAIRPSD-LPPVVL GPVGLKPEELTAVK---QDPSKLTPGKLTPVVLGPEELWLAKLRPEVLR-PEVPRPVDIG SGGFSDVRAQDR----LRGNAD-LAYVLNAD-PCGHCLIINNVNFY--LAS-------GL GRRVGSDIDCEKL-RQRFSLLHFMVEVKGDLTAKQMLRALGELARR-DHGALDCCVVVIL SHGCQASHLQFPGAVYGTDGC-------PVSIESIVNIFNGTGCPSLGGKPKLFFIQ--A CGGEQK-DPGCKVD--STS-PEDRTPGSDSEPDAVPFQEGPGTF----DQPDAVSSLPTP SDIFVSYSTFP--G--FVSWRDPKSGSWYVETLDGVFEQ-------WA--HSEDLQ---- -------TLLLRVAHAVSEKG--------------VYKQIPGCFN-----FLRKKFFFKT Y------------------ >R_norvegicus_ENSRNOP00000016613 -----------------------------------------------------------M DFHSCLYDIAER----LGNEELAALKFLCLDHIPQKKQESI------------------N DVLVLFQRLQE-EG-MLEEDNLSFLKELLFHISRRDL----------------------- ------------------------------------LSRVLKSSPEEMVRELQVLGKAQV SAY--------------------------------------------------------- -------RVMLFKLSEDMDKEDLKSFKFLLITEIPKCKLQDNSSLLDIFVEMEKRTILAE NNLVTLKSI-------CFRVNRSLLGRIDDYE---------------------------- ------------------------------------------------------------ -------------------------------------------RSSTERRMSTE------ -------------------------------------------GGEELPVSVLDEVTIKM QDMWDSPGEQES----ESLNSD-NVYQMKSK-PRGYCLIFNNNNFS--KAREDIPKLSNM RDRKGTNYDEEAL-SKTFKELHFEIVSFSDCTASQIHEVLVSYQSK-DHKGKDCFICCIL SHGDK-------GIVYGTDGK-------EASIYELTSYFTGSKCPSLAGKPKIFFIQ--A CQGNNF-QKAVPVPDETGL-EQ-EHVLEED-------------------SSSYKNYIPDE ADFLLGMATVK--N--CVSYRDPTRGTWYIQSLCQSLRE-------RCP-RGEDIL---- -------SILTGVNYDVSNKD---N-------PRNMGKQMPQPIF-----TLRKKLFFPP N------------------ >G_gallus_ENSGALP00000013571 ---------------------------------------------------------MSS DFRKLLFDISEA----LATEELAALKFLSLEHVPVRKQEDT------------------E EPKAFFEVLKE-KG-MIEVEDLFFLKELLYRINRIDL----------------------- ------------------------------------LASHLGSSREEMERELQVPGKAKV SAY--------------------------------------------------------- -------RQLLYGIAEDLTPDDVRSIKFLLQEKLPKNKLQDNASMLKVLVEMERNGIIKE DDLTMLKSI-------LKAFRADLKKKIDNYE---------------------------- ------------------------------------------------------------ -------------------------------------------EKTKGWPWKSSCFPNK- -------------------------------TQALSISENLAVSSLIDNKESQESQSEWY SAGIFPPH--------VQILLV-ESYKMENN-PHGYCVILNNYRFK--NPN--------- ETRKGTVEDGKAL-KRVFKWLQFDTIEYMDLEAKQIFAKVNEYSKK-DHSNMDCFVCFIL SHGEK-------GKIKGVDNE-------LVNIKDLLSCFSGSNCPSLAGKPKLFFIQ--A CQGSVG-HPAVTVK--EDC-SGHL-----------------------ETDAIPALSIPDQ ADVLVGMATVE--D--FECYRSIETGSVYIQCLCDKMEL-------LCP-LRKDLI---- -------TILTEVNKEVGRRV------------LNGWKQMPKITS-----TLRKQFIFQI PQCQ--------------- >C_familiaris_ENSCAFP00000005409 -----------------------------------------------MAAASAGRPAALQ RKAPTAAGRGRR----ILGVCGMHPDHQEALKKNRVVLAKQ------------------L LLSELLEHLLE-KD-IITLEMREHIQAK----VGGFS------QNVE------------- ------------------------------------LLNLLPKRGPQA------------ ------------------------------------------------------------ -----------------------------------------------FDAFCVALRETKQ GHLEDLLLT-------TLSG--LQ--------------HGLPP-------------LSCD YDLSLTF----PMCESC-----------------PPQKQLR------------------- --------------------------------------LSP-DTVEH------------- --------------------------------------------------SLDNGDGPPC --LQVKPCTPEF----YQTHYQ-LAYRLQSR-PRGLALVLSNVHFT--GEK-------DL EFRSGGDVDHSTL-VTLFKLLGYKVHVLLDQTAQEMKEKLQNFAQLPAHRVTDSCIVALL SHGVE-------GGIYGVDGK-------LLQLQEVFRLFDNASCPNLQNKPKMFFIQ--A CRGDET-DRGVDQQ--DGK-NHTGSSECEESDASK--------------EELLKTRLPTR SDMICGYACLR--G--TAAMRNTKRGSWYIEALTQVFSE-------RA--CDTHVA---- -------DMLVKVNALIKERE---G--YAPGTEFHRCKEMSEYCS-----TLCRHLYLFP G-HPPT------------- >A_carolinensis_ENSACAP00000001629 ------------------------------------------------------------ -FRQILLAIDEN----LGKEDVDAMKFLCSDFISTKHLEGV------------------E TAQDIFQLLIN-RN-LLSKEDTFIVAELLYRIKCHF------------------------ ------------------------------------LLQKIGYTQQKVEHNL--FHIRNV SEY--------------------------------------------------------- -------RQMLYEISEGFTEENVKTAMFLLREHLPKKQS----IAVKLLTSLEKQDLLAE DKLAILEKI-------CNKVSPELRNKVDKFK---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------ERSVFKAFVFSLCYE NLYPSNFLAVFL----LILQAS-TCYKMDGL-NRGSCLIFNNVHFE--G---------GL SQRRGSQKDAEEL-ESVFRWLGLDVIKYNDTTSIEMENHLKQWQSFENWKDMDCLVCCIL SHGES-------GKIYGTDGN-------LIPIRTIMSYFTAKQCPQLAKKPKLFFIQ--A CQGEKT-QQPVYLE--TDD-EYGS-----------------------FPLQQMISSIPEE ADFLLGMATVD--G--YLSFRHVHQGTWYIQALCDKLRT-------LVP-RGEDIL---- -------SILTEVNADVSRRA---D-------AQGQKKQMPQPAY-----TLRKKLIFPI P------------------ >T_rubripes_ENSTRUP00000031759 -----------------------------------------SMQMAGEPTEISDLGGEVE EGGQSEDDVDAK----PDRKGRFLLFKS-KKNKDGQMREQD------------------Y CSESHYRIVSP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------T-FQYKMSHQ-RVGKCIIINNKNFD--EKT-------GM NVRNGTDRDAGEL-FKCFKTLGFDVFIYNDQTCEKMERLLREASEE-DHSDSSCFACILL SHGEE-------GMIYGTDGA--------MPIKTMTSMFRGDMCKSLVGKPKLFFIQ--A CRGSEF-DDGIQTD--SGP-PN----------------------DTMETDANPRHKIPVE ADFLFAYSTVP--G--YYSWRNPGRGSWFVQALCNVLSE-------FG--KQLEIM---- -------QILTRVNYMVATSF---ESW-SEDPRFSEKKQIPCVVS-----MLTKELYFKQ C------------------ >A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------T-FRYRMDYK-KLGKCVIINNKNFA--KDT-------GM RIRNGTDKDAGDL-QKCFRGIGFDVSIYNDLTCDNMEKILGEAALE-NHDDAACFACILL SHGEE-------GLIYGTDGC--------MAIKNLTGLFRGDKCQSLIGKPKLFFIQ--A CRGSEF-DAGIQTD--SGS-SN----------------------DNLEMDANPRYKIPVE ADFLYAYSTVP--G--YFSWRNPGKGSWFVQSLCSVLND-------HG--KELEVL---- -------QILTMVNYKVARNY---ESQ-SDDPRFSQKKQVPCVVS-----MLTKELYF-- ------------------- >C_familiaris_ENSCAFP00000023986 ------------------------------------------------------------ ----------------------MDEAERRALRRCRVRLVRE------------------L QVAALWDALLS-RE-LFTAAMVEDLQHAGSG--SRSD------QARQ------------- ------------------------------------LVIDLETRGSQA------------ ------------------------------------------------------------ -----------------------------------------------LPLFISCLEDTGQ DALASCLTM--------------------------------------------------- ------------------------------------------------------------ -------------------------------------SRQAVKQNPEATRPLD-LMPVVL GPTRLTPEDLRG-----KDPSKLTPGKLAPVVLG-----PAELQPQVVR-PSVPRPTDNG SGRFSDVCEYQESGWWVAGPIK-LAYALNAD-PCGYCLIINNVNFC--PES-------RL TARGGSNIDCEKL-QRRFCLLRFTVEVKWDLTAKQMVQALVELARR-DHSALDCCVVVVL SHGCEASHRQFPGAVYGTDGC-------PVSIEKIVNIFNGTGCPSLGGKPKLFFIQ--A CGGEQK-DHGFAVA--SAS-PEDRSPGSDSEPDAVPFQEGPGPF----DQLDAVSSLPTP SDIFVSYSTFP--G--FVSWRNTKSGSWYVETLDGVFEQ-------WA--HAEDLQ---- -------TLLLRVANAVSQKG--------------VYKQIPGCFN-----FLRKKLYFKM ------------------- >O_cuniculus_ENSOCUP00000003895 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------NSLHLLEHLEKRDDIHE DNLTYLEDL-------CKKVAPSLMRIIEKYK---------------------------- ------------------------------------------------------------ -------------------------------------------NEKXX---XXXXXXXXX XXXXXXXXXXXXXXX--XXXXXXXXXXVT-----------------------PALASVEL LRAPADFLRLET-----STREA-NVYRMDRK-HRGRCVIVNNEIFT-----------TYL SDRRGTQRDAEQ--KLVFQWLGFKVHKCDNKTKEDLEALLQEEKHHPDHDDGDCFVFCVL THGIF-------GAVYSSDGV-------LIPIREIVSHFTAKQCPGLAGKPKLFFIQ--A CQGKEI-QSSAPIE--ADA-VNPE-----------------------CVPPSLQDSIPVE ADFLLGLATVP--G--YASLRHVENGSWYIQSLCNHLKA-------LVP--HEDIL---- -------SILTAVNNDVSRQA---D-------KSGRMRQMPQPAF-----TLRKRLVFPV P-QEEPSF----------- >O_anatinus_ENSOANP00000002508 -----------------------------------------------MADDQAPTMHQKE --CDFEDEVDAK----PERLKVAQLFSK--KKNEAESQS-G------------------G PLPVRNRVVSS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------S-FIYNMKYE-NLGKCIIINNKNFA--SKT-------GM STRNGTDKDAGNL-QKCFRSLGFDVSVFNDFSCNQMKEILQKASEE-NHENSACFACILL SHGEG-------DCIYGTDDF--------IPIKELTILFRGDKCKSLLGKPKLFFIQ--S CRGTEF-DDGIQTD--STP-VT----------------------D---SDANPGCRIPVE ADFLFAYSTVPVKG--YYSWRNVDRGSWFVQALCSVLHE-------HG--KELEIM---- -------QLLTRVNHQVAINF---ESQ-ASDPRYCQKKQIPCLVS-----MLTKELYF-- ------------------- >M_domestica_ENSMODP00000001598 ------------------------------------------------------------ -----------R----MLGVWGMEQEHQEALKKNRVVLAKQ------------------L LLSELLEHLLE-KD-IITLEMRELIQAK----VGSFS------QNVE------------- ------------------------------------FLNLLPKRGPHA------------ ------------------------------------------------------------ -----------------------------------------------FEAFCDALRETKQ GHLEDLLHR-------TLYS--FQ--------------NLRPP-------------LGCD YDSSFPL----PVCDSC-----------------PPHKQLR------------------- --------------------------------------LSV-ETMEH------------- --------------------------------------------------SLDNGDGPPS --LQVKPCTPEF----YQTHQH-LAYRLQSR-PRGLAMVLSNVHFN--GEK-------DL EFRSGGDVDHSSL-VTLFKLLDYDVHVLRDQTAQKMQENLQRFAQLSAHQSTDSCMVALL SHGIE-------GGIYGVDGK-------LLQLQEVFRLFDNANCPNLQNKPKMFFIQ--A CRGDET-DRGVDLR--DGK-EHVASPGCEESDAGK--------------EKILKMRLPTR SDMICGYACLK--G--TAAMRNTKRGSWYIEALTQVFSE-------RA--RDMHVA---- -------DML--VNALIKDRE---G--YAPGTEFHRSKEMSEYSS-----TLCRHLYLFP G-HPPT------------- >M_domestica_ENSMODP00000004412 ------------------------------------------------------------ ----------------------MEESQRELFQKNRLRLVCE------------------L QVEPLWDLMLD-RE-LFTRDMIEDIQRAG----TRRD------QARQ------------- ------------------------------------LVTDLQTRGKRA------------ ------------------------------------------------------------ -----------------------------------------------LPIFISCLEATGQ WDLAALLSE--------------------------------------------------- ------------------------------------------------------------ -------------------------------------SNTTLTQQPDPIDIKPVEMIRSG GLRSTGRYTSMVSLHLLLLANSPFLYFIDAVLVSAHNLFPLELIKRQ---PTFSKVLSLL YKLRFPFCPPPQ--------VG-QVYTLNSD-PCGYCLIINNVDFC--ASS-------GL SSRKGSNIDCEKM-HNRFQALHFAVEVERNLSAKGMGAALQQLAER-DHSALDCCVVVIL SHGCQASHIQFPGAIHGTDGA-------SISVERIVNIFSGSRCPSLGGKPKLFFIQ--A CGGDQR-DHGFQVS--SNI-PEDKSPGSDPETDATPFQNNF-------DQPDAVASLPTP SDILVSYSTFP--G--FVSWRDPKSGSWYIETLDRVLEE-------WA--DREDLL---- -------HMLLMVSNAVSARG--------------TYKQIPGCFN-----FLRKRFFFKT K------------------ >G_gallus_ENSGALP00000014503 ------------------------------------------------------------ ------------------------------KKKNGEEEQPK------------------S SLSNQYRIVTP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------T-FQYNMNYK-KVGKCIIINNKNFE--DKT-------GM GTRNGTDKDAGDL-SKSFRSLGFDVYTYNDRSCEDMQTLLKQAAEE-NHSDAACFACILL SHGEE-------GLIYGTDGP--------MAIKHLTTLFRGDKCKTLIGKPKLFFIQ--A CRGSEF-DEGIQTD--SGP-AN----------------------DTLETDANPRYKIPVE ADFLFAYSTVP--G--YYSWRNPGRGSWFVQSLCSVLNE-------HG--KQLEIM---- -------QILTRVNYVVATNF---ESQ-SDDPRFSEKKQIPCVVS-----MLTKELYF-- ------------------- >O_latipes_ENSORLP00000003208 ------------------------------------------------------------ ----------------------MEEKHKRILRRNRVHLVKE------------------L DLSDLCDVLLR-KD-VFTQSMINDIKRQNCE--TKRD------QARK------------- ------------------------------------LVKDLETRGNEA------------ ------------------------------------------------------------ -----------------------------------------------FSAFLEGLRVTGQ QNLLELLQK--------------------------------------------------- ------------------------------------------------------------ -------------------------------------SAPRVHFQP-GKSTEAGYLLIQP HPVYIEDAVPKKPRT--QPSPRKRERRGGGVKVPHNIFIDKVKSDIFDSKSRFRNNDNTN VCTHLTRCSRGQ----RSDHDG-TASRMDAR-PCGLCLIINNVEFE--PKT-------EL SIRKGSNVDCDKL-EKRFKSLNFVVEVRTNLKQRQIKSELSALSRK-DHSIYDCCVVVIL SHGTEVSHNRFPGAVYGVDGN-------HVSVQEITNYLNGQNCPSLQSKPKIFFIQ--A CGGGEK-DIGFEVS--PDE-AKPSIGGDGDQTDAIPFSSSSESLS-TSDETDAIPTLPTP SDILVSYSTFP--G--YVSWRATVSGSWYVEVLDNILEE-------HA--ATLDLT---- -------TMLTLVNDKVSQNS-----------AKGLYKQMPGSFN-----FLRKHVYFQT S------------------ >D_rerio_ENSDARP00000075318 ------------------------------------------------------------ ----------------------MADQLLENLRPDLIKGLSE------------------R VINGLLDDLQQ-KK-VFGEEEIEDIQHRM---KTRAD------QARH------------- ------------------------------------VIDDVKRKGVKA------------ ------------------------------------------------------------ -----------------------------------------------SEIMLASLKTRDP HLYDTL------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GIERLLVPVPETELT PSQLSETTGCST----DKTNTM-NEYEMKSN-PRGLCLIFNNENFK--DPD--------- MKRHGSQMDTASL-KDLFEWLGFSVEIKQDQTVSAMKRTLKEYSE--DRKHGDCFVCCVL SHGNE-------SGVLGSDEK-------ICPVDDITSPFNGANCSSLAGKPKVFFIQ--A CRGHEI-QSKVMVA--DGS-GGSR----------------------TQKPGRVSVSIPKD SDFLIARSTVE--G--YVSIRDRTSGTWFIQSLCENLKE-------GSK-RGHDIL---- -------MILTKVNNDVSRKE---G-SLKVKNEIVDAKVTPQPIF-----TLRKLLIFRP L-KKTGRFS---------- >M_mulatta_ENSMMUP00000016588 ------------------------------------------------------------ -----------R----ILGVCGMHPHHQETLKKNRVMLAKQ------------------L LLSELLEHLLE-KD-IITLEMRELIQAK----VGSFS------QNVE------------- ------------------------------------LLNLLPKR-PQA------------ ------------------------------------------------------------ -----------------------------------------------FDAFCEALRETKQ GHLEDIELK-------LRVS--AL--------------MKPTG-------------LGSD YNDILGL----MVKLNT-----------------VFWFSV-------------------- --------------------------------------YTT-DTVEH------------- --------------------------------------------------SLDNKDGPVC --LQVKPCTPEF----YQTHFQ-LAYRLQSR-PRGLALVLSNVHFT--GEK-------EL EFRSGGDVDHSTL-VTLFKLLGYDVHVLRDQTAQEMQEKLQNFARLPAHRVTDSCIVALL SHGVE-------GAIYGVDGK-------LLQLQEVFRLFDNANCPSLQNKPKMFFIQ--A CRGDET-DRGVDQQ--DGK-NHAGSPGCEESDAGK--------------EKLPKMRLPTR SDMICGYACLK--G--TAAMRNTKRGSWYIEALAQVFSE-------RA--CDMHVA---- -------DMLVKVNALIKDRE---G--YAPGTEFHRCKEMSEYCS-----TLCRHLYLFP G-HPPT------------- >T_nigroviridis_ENSTNIP00000001216 ------------------------------------------------------------ ------------------------------------------------------------ SAYQLFLSLCD-QD-HLSEERPHLLSELLSIIQRTR------------------------ ------------------------------------LLRDLDLRSSAT--------SNLI SAY--------------------------------------------------------- -------RKLLYSLSEDLTDDNLKEIKFLLTETLPRRKLEDNVTTLEVFLELECMDLLSK TNLGLLKSI-------LQPVCPVLAERIRQFE---------------------------- ------------------------------------------------------------ -------------------------------------------AQNSCQPAADWGFAVKK ITDPLQVQGGSDALP--------------SLPEENQSSSRTEASVMSSANAVGIKPGTLM LGLSPPPVGSPN----FPVQDL-GTYPMTTL-PRGCCLIISNYDFQ--GS--------GL GMRNGTRTDEECL-KKVFEWLGFKVEIHRDCTGKEILSLMQELADK-SQQRWDCLVCCIL SHGLE-------GCVHGVDGD-------QVSIKKLIEPFLGTNCPAMAGKPKLFFIQ--A CQGKKQ-QGVVHLE--SDG-AEHS-DVDTD-------------------AVRLSNCIPSH ADFLLGMATVP--D--YVSYRDRERGTWYIQSLCEYLVK-------MVP-RGFDLM---- -------SILTKVNEDVSKKN---D-------NTGDRKQMPQPVF-----TITKRIVFPV P-SGPAPVLPHFPFVEDSP >D_rerio_ENSDARP00000041413 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------MALIFNQKQFD--WKL-------GL KTRNGTDKDRDDLVSRRFQELNFEVKAYNDYSRDDVLLKIQEASAA-DHVDADCFVCIFL SHGED-------GHVYANDKK--------IEIPEITDLFKGDKCRSLVGKPKIFIWQKQA CRGDKL-DDAVTEM--SVEDVE------------------------MAVDAGVLYTLPAG ADFIMCYSTAE--G--FCSFREPLNGSWYIQDLCEILGR-------YH--SELQFT---- -------DILTLVNMKVSLRS---VPN-CRNRAAIGKKQMPCFAS-----MLTKRLFFRD N-TQIQ------------- >T_guttata_ENSTGUP00000011206 ------------------------------------------------------------ ------------------------------KKKNGEEEQPK------------------P SLSNQYRIVTP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------T-FQYNMDYK-KVGKCIIINNKNFE--DKT-------GM GTRNGTDKDAGDL-AKSFKNLGFEVDIHHDRSRDDMEKLLKKAAEE-NHSDAACFACILL SHGEE-------GLIYGTDGP--------MAIKSLTALFRGDKCKSLIGKPKLFFIQ--A CRGSEF-DEGIQTD--SGP-AN----------------------DTLETDANPRYKIPVE ADFLFAYSTVP--G--YYSWRNPGRGSWFVQSLCSVLNE-------HG--KQLEIM---- -------QILTRVNYVVATNF---ESQ-SDDPRFSEKKQIPCVVS-----MLTKELYF-- ------------------- >A_gambiae_AGAP011949-PA ------------------------------------------------------------ ------------------------------------------------------------ -----MDSILE-FE---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------L-KSYDTTHP-NRGIAVVINDS----------------- ERREGSEKDVQDV-VATLEGLKFNVRTFQDNTKKEIKKALYKVARE-DHNENDCLVIVAM AHGKK-------DHITLKKEK--------LRIDKLWASFVGNKCPSLIGKPKLVFIQ--T CRGDNV-DFGVASH--ETD-STPC------------------------SVDPAPGIIPMY ADLLVMYSSYD--R--HISVRCKDKGSWFIQSLCQVLRA-------NI--AGKELI---- -------SLLTQVSYIVSCQT---S----ITSDGETVKQIPSINS-----MLTKAFYFVP K-QTQQIS----------- >D_rerio_ENSDARP00000024255 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQYEMKGE-RRGVCLIINNYDFS--AC--------GW LNREGTDIDHDSL-RDVFEWLGFEILTRRDCTGDQILQALMDLSTQ-DHTQADCVVCCIL SHGRL-------NDIIGVDGK-------AVPFKELMETLSPFRCSSLYQKPKLFFIQ--A CRGTQN-QRAVFPQ--TFT-EDED-VLASD-------------------AGVPRDSIPEM ADYLMAMSTVP--W--YASYRDKSKGTWFIQSLCDNLRL-------LVP-RGNDLL---- -------SILTKVNADVSKKS---D-------KSGLKKQMPQPEF-----SLTRTVVFPP P-GLP-------------- >T_nigroviridis_ENSTNIP00000022078 --------------------------------------------MAGEAAGIPELGGEAE GEHRCEDDVDAK----PDRRGRFLLFKS-KKKNDGQMREQD------------------Y CSESHYRIVSP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------T-FQYRMSHQ-RVGKCIIINNKNFD--EKT-------GM NVRNGTDRDAGEL-YKCFKSLGFDVFIYNDQTCEKMEHLLREASEE-DHSDSSCFACILL SHGEE-------GMIYGTDGA--------MPIKTMTSMFRGDMCKSLVGKPKLFFIQ--A CRGSEF-DDGIQTD--SGP-PN----------------------DTMETDANPRHKIPVE ADFLFAYSTVP--G--YYSWRNPGRGSWFVQALCNVLNE-------FG--KQLEIM---- -------QILTRVNYMVATSF---ESW-SEDPRFSEKKQIPCVVS-----MLTKELYFKP C------------------ >G_aculeatus_ENSGACP00000008661 -----------------------------------------QVNGA-RLTSAQDVA--AE EGGPTGDQTDAK----PDRRGRFLLFGNIKKNKDGQTREQD------------------Y SSESHYRVVSP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------T-FQYKMSHQ-RVGKCIIINNKNFD--EKT-------GM NVRNGTDRDAGEL-FKCFKSLGFDVFIYNDQTCGKMESLLREASEE-DHSDSSCFACILL SHGEE-------GMIYGTDAA--------MPIKSMTSLFRGDMCKSLVGKPKLFFIQ--A CRGSEF-DDGIQTD--SGP-PN----------------------DTLETDANPRHKIPVE ADFLFAYSTVP--G--YYSWRNPGRGSWFVQALCNVLNE-------FG--KQLEIM---- -------QILTRVNYMVATSF---ESW-SEDPRFSEKKQIPCVVS-----MLTKELYFN- ------------------- >C_familiaris_ENSCAFP00000017899 -----------------------------------------------------------M DFSKCLYNIGEQ----LDSDELASLKFLSLDYIPQKKQEPI------------------K DPLMLFQRLQE-KR-MLEESNLFFLKELLFRINRLDL----------------------- ------------------------------------LMTYLDTSKEDMQQELQIPGRAQI SAY--------------------------------------------------------- -------RVMLFQISEDVSKLELKSFKFLLSREISRCKLDDDLNLLDIFIEMEKRVILGE RNLDTLKRI-------CDQINKSLLKKITDYE---------------------------- ------------------------------------------------------------ -------------------------------------------ELNREQTMNLQ------ --------------------------------------RSLDEISNDMSQLPIREGSVKI LPMSDSLGEQDY----ESETSD-KVYRMKSK-PRGYCLIFNNYDFS--VARREVPKLQSI KDRNGTDLDADAL-SKTFSELHFEIVHFKDATAKKICEVLQSYQSM-DHSSKDCFICCIL SHGDK-------GIIYGSDGQ-------EAPIYELTSYFTGSKCPSLAGKPKIFFIQ--A CQGDKY-QKGIAVE--TDS-EQKEAYLEMD-------------------SSYQKRYIPED ADFLLGMATVN--N--CVSYRNPMEGTWYIQSLCQSLRE-------RCP-RGEDIL---- -------TILTEVNFEVSNKD---D-------RKNMGKQMPQPTF-----TLRKKLFFPP N------------------ >C_elegans_C48D1.2 ------------------------------------------------------------ ---------------------MMRQDRRSLLERNIMMFSSH------------------L KVDEILEVLIA-KQ-VLNSDNGDMINSC----GTVRE------KRRE------------- ------------------------------------IVKAVQRRGDVA------------ ------------------------------------------------------------ -----------------------------------------------FDAFYDALRSTGH EGLAEVLEP-------LARS------------------------------------VDSN AVEFECP----MSPASHRRSRALSPAGYTSPTRVHRDSVSS------------------- --------------------------------------VSSFTSYQDIYSRARSRSRSRA LHSSDRHNYSSPPVN--AFPSQPSSANSSFTGCSSLGYSSSRNRSFSKASGPTQYIFHEE DMNFVDAPTI-S----RVFDEK-TMYRNFSS-PRGMCLIINNEHFE------------QM PTRNGTKADKDNL-TNLFRCMGYTVICKDNLTGRGMLLTIRDFAKH--ESHGDSAILVIL SHGEE-------NVIIGVDDI-------PISTHEIYDLLNAANAPRLANKPKIVFVQ--A CRGERR-DNGFPVL--DSVDGVPAFLRRGWDNRDGPLFNFLGCVR--PQVQQVWRKKPSQ ADILIAYATTA--Q--YVSWRNSARGSWFIQAVCEVFST-------HA--KDMDVV---- -------ELLTEVNKKVACGF---Q----TSQGSNILKQMPEMTS-----RLLKKFYFWP E-ARNSA-------V---- >G_gallus_ENSGALP00000017288 -----------------------------------------------------MMTDIKD GPRSGEDVSDAR----SFPGSKGMN----------------------------------L PASKSVDSGIL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PD-DSYRMDYP-EIGVCVIINNKNFH--RDT-------GL SSRSGTDADAASV-REVFMKLGYKVKLNNDLSSRDIFKLLKNVSEE-DHSKRSSFVCVLL SHGDE-------GLFYGTDGP--------LELKVLTSLFRGDKCRSLAGKPKLFFIQ--A CRGTEL-DSGIEAD--SGP-DE-----------------------------TVCQKIPVE ADFLYAYSTAP--G--YYSWRNAAEGSWFIQSLCRMLKE-------HA--RKLELM---- -------QILTRVNRRVA-EY---ESC-STRQDFNAKKQIPCIVS-----MLTKEFYFPC ------------------- >D_rerio_ENSDARP00000019984 -----MDKEALTSENEVSGDDQENYGKGDVTDAKPDPKAMCRVDKE-ALTSEIEVLEEDQ DSYGEEDVTDAK----PDRKGRFRLFGN-FKKNDGKLQEKG------------------- ESESHYRIVSP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------T-FQYKMSHQ-RVGKCIIINNKNFD--EKT-------GM NVRNGTDRDAGEL-FKCFKSLGFDVAVYNDQTCRNMERLLKAVSEE-DHSDSSCFACILL SHGEE-------GMIYGTDGA--------MPIKTMTSLFKGDVCKSLVGKPKLFFIQ--A CRGSEF-DDGVQTD--SGP-PN----------------------DTIETDANPRHKIPVE ADFLFAYSTVP--G--YYSWRNPGRGSWFVQALCNVLSE-------FG--KQLEIM---- -------QILTRVNYMVATSF---ESW-SEDPRFSEKKQIPCVVS-----MLTKELYFN- ------------------- >A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------ -----------------------------------------------------------I PVSKSVDSVIE------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------AD-ESYRMDHP-EMGLCILVNNKNFH--PAT-------GM SYRSGTDRDAAHV-VDTFRTLGYMVKPYNDLTCKQIVDVLHNVSKD-DHHKRNSFVCVLL SHGED-------GLIYGTDGH--------VELKMLTSFFRGDKCKSLAGKPKLFFIQ--A CRGTEL-DSGIETD--SAS-DE-----------------------------SMCQKIPVE ADYLYAYSTAP--G--YYSWRNSSDGSWFIQSLCSMLKQ-------YS--HKLELM---- -------QILTRVNRKVT-EF---TSC-SNHPDFHGKKQIPCIMS-----MLTKDFYFPH ------------------- >G_gallus_ENSGALP00000013591 -----------------------------------------------------------M EFSQLLFVISEA----LDRTELASLKFLSLEHVTVRKREDI------------------E EPKAFFQALQE-KG-MIEVGDLFFLKELLYRINRIDL----------------------- ------------------------------------LASYLGSSREEMERELQVPGRARV SPF--------------------------------------------------------- -------RYLLFQLSENITKDDMKCFKFLLGKELPKCKLSPETTMPDVFIEMEKKGILKE DNLTVLKTI-------CGKVDKSLLKKIEDYE---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LNLLGEGEMLVTEGQRSSTGAPEDSAIWL ASSVAPDSLGNC----DQSSQL-EVYKMTSR-PRGVCLILNNHNFA--KAREAVPELRRM KDRNGTHVDADAL-RKVFSNLHFTVAEYKDCTAEEIRNIVNNYRCM-DHNNKDCFVCCIL SHGKK-------GIIYGVDGQ-------EVPIQELTTSFTGQNCQSLAGKPKVFFVQ--A CQGDAY-QKGVTIE--TDS-GEQDYSLETD-------------------ARFQLDCIPSE ADFLLGMATLQ--D--YVSYRSPSQGTWYIQSLCQHLES-------SCP-RGEDIL---- -------TILTAVNQEVSSKI---D-------KQNAGKQMPQPSF-----TLRKKLIFPV N------------------ >H_sapiens_ENSP00000311032 ------------------------------------------------------------ -MENTENSVDSK----SIKNLEPKI----------------------------------I HGSESMDSGIS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------LD-NSYKMDYP-EMGLCIIINNKNFH--KST-------GM TSRSGTDVDAANL-RETFRNLKYEVRNKNDLTREEIVELMRDVSKE-DHSKRSSFVCVLL SHGEE-------GIIFGTNGP--------VDLKKITNFFRGDRCRSLTGKPKLFIIQ--A CRGTEL-DCGIETD--SGV-DD----------------------------DMACHKIPVE ADFLYAYSTAP--G--YYSWRNSKDGSWFIQSLCAMLKQ-------YA--DKLEFM---- -------HILTRVNRKVATEF---ESF-SFDATFHAKKQIPCIVS-----MLTKELYFYH ------------------- >X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------ ----------------------------STKKKKTEDPEKP------------------P QASDNVRIVTP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------A-FQYKMNYG-KVGRCIIINNKNFD--DIT-------GM SPRNGTDIDARDL-LRCFKGLGFDVTVFNNKSCTEMETLLRSVAEQ-DHKDSACFACIFL SHGEE-------GLIYGTDGA--------MPIKVLTTLFRGDKCRSLVGKPKLFFIQ--A CRGCEF-DDGLETD--AGP-SN----------------------DSLETDANPRHKIPVE ADFLYAYSTVP--G--YYSWRNPGRGSWFVQALCNVLNE-------HG--KELEVM---- -------QILTRVNYLVATQF---ESY-CDDPQFNKKKQIPCVVS-----MLTKELYFKP C------------------ >R_norvegicus_ENSRNOP00000014096 ------------------------------------------------------------ -MDNNETSVDSK----SINNFETKT----------------------------------I HGSKSMDSGIY------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------LD-SSYKMDYP-EMGLCIIINNKNFH--KST-------GM SARNGTDVDAANL-RETFMALKYEVRNKNDLTREEIMELMDSVSKE-DHSKRSSFVCVIL SHGDE-------GVIFGTNGP--------VDLKKLTSFFRGDYCRSLTGKPKLFIIQ--A CRGTEL-DCGIETD--SGT-DD----------------------------DMACQKIPVE ADFLYAYSTAP--G--YYSWRNSRDGSWFIQSLCAMLKL-------YA--HKLEFM---- -------HILTRVNRKVATEF---ESF-SLDATFHAKKQIPCIVS-----MLTKELYFYH ------------------- >A_aegypti_AAEL003444-PA ------------------------------------------------------------ -----------------------------------------------------------M DTTDELDVLGF-GSR--------------------------------------------- ------------------------------------TNESSKSIKEAL------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------V----SRAALD-EYYDTTNK-RRGIALVFCHMNFS------------VM AKRNGADKDRDDI-CNTLYGLDFDVRVFDDLSRKEVLDRLKDVSRE-DHSDNDCLVVVMM SHGEQ-------GVLYARDNK--------YNVDSLWKNFVGNACPSLIGKPKMFFIQ--A CRGEQF-DEGVAYA--AKS-PKDMVDS---------------------RQEQVLYSIPAM ADLLVMYSTYD--G--YYSWRNPRQGSWFIQSLCTELDE-------NG--RVRDLL---- -------TLLTGVSRRTAYEF---QSFVPHNAKMDAMKQIPCIVS-----MLTKTFYFTK K-TRSRV-------VTDID >E_caballus_ENSECAP00000019797 ------------------------------------------------------------ -MENSKISVDSK----SIKNSETKI----------------------------------L HGSKSMDSGIS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------LD-SSYKMDYP-EMGLCIIINNKNFH--KST-------GM ASRSGTDVDAANL-RETFTNLKYEVRNKNDLTGEEIVALMRSVSKE-DHSKRSSFICVLL SHGEE-------GIIFGTNGP--------IDLKKLTCFFKGDCCRSLAGKPKLFIIQ--A CRGTEL-DSGIETD--SGI-ED----------------------------DMACQKIPVE ADFLYAYSTAP--G--YYSWRNSKDGSWFIQSLCAMLKL-------YA--HKLELM---- -------HILTRVNRKVAMEF---ESY-CLDPTFHGKKQIPCIVS-----MLTKELYFYH ------------------- >D_rerio_ENSDARP00000075650 ------------------------------------------------------------ ---------------------MDKKESVDKICENKIFLLET----------------LSV DANFILQHVQQ-AK-LITLRDYNNLSDFPQRETKIIN----------------------- ------------------------------------LLDKLMGKGEET------------ ------------------------------------------------------------ -----------------------------------------------CHQFIALLRQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------DCVLE NFPMLKDHDIFD----SSVQEI-SPYRIIKN-PRGICVIINNEIFS--S---------GM MSRRGSDKDREYL-AKVFHWLGFEVVEHNNKDTAEIRNILKDLGRT---VDGDCFVCCIL SHGRR-------EGVCGTDGN-------YLSIDEIRDPFTGVKCQKLVGKPKLFFIQ--G CRGANSLQACVKVE--ADA-GNSK---------------------AKVEGDNLDITIPSD TDFLIARSTTN--G--HVSYRHVREGSWFIQSLCRNLEK-------HCP-RGADIL---- -------TILLYVNNEVSSQK-------------SIRKQMPIYEV-----ALTRKLFLRP V-NP--------------- >P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------ -MENTENSVDSK----SIKNLEPKI----------------------------------I HGSQSMDSGIS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------LD-NSYKMDYP-EMGLCIIINNKNFH--KST-------GM TSRSGTDVDAANL-RETFRNLKYEVRNKNDLTREEIVELMRDVSKE-DHSKRSSFVCVLL SHGEE-------GIIFGTNGP--------VDLKKITNFFRGDRCRSLTGKPKLFIIQ--A CRGTEL-DCGIETD--SGV-DD----------------------------DMACHKIPVE ADFLYAYSTAP--G--YYSWRNSKDGSWFIQSLCAMLKQ-------YA--DKLEFM---- -------HILTRVNRKVATEF---ESF-SFDATFHAKKQIPCIVS-----MLTKELYFYH ------------------- >E_caballus_ENSECAP00000004055 -----------------------------------------------------------M NFNSCLYNIGEQ----LDSDELASLKFLSLDHIPQRKQEPI------------------Q DALMLFQRLQE-KR-LLEESNLSFLKELLFRINRLDL----------------------- ------------------------------------LTTELDTSKEEMERELQSPGRAQI SAY--------------------------------------------------------- -------RVMLFQISEDVNKLELKSFKFLLSRELPKCRLDDDMILLDIFIEMEKRVMLGE RNLDTLKKI-------CEQVNKSLLKKINDYE---------------------------- ------------------------------------------------------------ -------------------------------------------ELSREGRISLE------ --------------------------------------RSPDEFSNASLKCLQREGSLAG QAMSDSPGQQNS----ESQTSD-KVYRMESK-PRGYCLIFNNHDFS--AARRDVPKLQNI KDRNGTDLDAEAL-SMTFTELHFEVVPYKNSTAKDICDALREYQEM-DHKKKDCFICCIL SHGDK-------GIIYGCDGQ-------EASIYELTSYFTGSNCPSLAGKPKIFFIQ--A CQGDNY-QKGIAVE--TDS-ELTDAYLEMD-------------------SSFQKRCIPDE ADFLLGMATVN--N--CVSYRNPLEGTWYIQSLCQSLRE-------RCP-RGEDIL---- -------TILTNVNFEVSSKD---D-------KKNMGKQMPQPTF-----TLRKRLVFPL N------------------ >T_rubripes_ENSTRUP00000035020 ------------------------------------------------------------ -----------------------MEDKLTSIRLMFVEKVST------------------Q MINQLLDDIFM-DG-IVSEMEKESITEES---NIRSD------KARR------------- ------------------------------------LIDSVRKKGERA------------ ------------------------------------------------------------ -----------------------------------------------CKKMISHIQSRDP ELSAVLGLS-------C------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------GHPAPPVFNRRAPDGRSRVIFNSPINRCVLEGETERQRRE RALKISPGNHSL----LLQSFQVYPGTREAI-NNRVALVITNITFF-----H------QC LNRKGAEKDEENM-ETLLKGLGYEVVKYRNLTGRAIEDAVIDFSKRPKLKDTDSVVVVIM SHGRL-------GVVAGVSTQSPTFEDDLFSLDKIYRHLGPEHCPALLNKPKIIIIQ--A CRGDER-GEIIFND--QHP-PENP-----------------PVSDDANIQEDAIRIEHKE KDFIWLLSCTP--D--TVSYRALAKGSFLVQVLVDVFNA-------SA--ERDDLE---- -------ELFRKVQHRFEDFP---I---------GNRRQMPTRDRC----TLTKRFYFYP G-L---------------- >A_gambiae_AGAP012544-PA ------------------------------------------------------------ --------------------------------MDATIINNN------------------H SSLEAMDSTLQ-LT---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------L-HSYNMAHP-KRGIAVVINNN----------------- RDRKGSEKDVKAL-QAVLSHLQFDVRLLSDKTTVEIRHALKEVSKE-DHTNNDCLAIIAM AHGYN-------DRIKFDDDY--------LHIDELWTNFVGNKCPSLIGKPKLVFIQ--S CRGGKL-DYGASIA--TAD-ARPG------------------------LEEPVDVKIPMY ADLLVMYSSFE--H--HSSIRCRNEGSWFIQSFCQVLGA-------NI--AKTELQ---- -------ALLCHVSYLVSIRS---DQ--TIDPEGKVVKQIPMVTS-----MLTKAFYFVP K------------------ >B_taurus_ENSBTAP00000024166 -----------------------------------------------MAAPSAGFQYPLQ PKEQMAADRGRR----MLRGCGMHPDHQEALKKNRVVLAKE------------------L LLSELLEHLLE-KD-IITLEMREHIQAK----TGSFG------QNVE------------- ------------------------------------LLNLLPKRGPQA------------ ------------------------------------------------------------ -----------------------------------------------FDAFCVALRETKQ SHLEELLLR-------TLSG--LQ--------------PVVPP-------------LSCD YDLSLPF----PVCESC-----------------TRHKRLH------------------- --------------------------------------LSP-DAVEH------------- --------------------------------------------------SLDHGDGPPC --LQVKPCTPEF----YQTHHH-LAYRLQSR-PRGLALVLSNVHFT--GEK-------DL EFRSGGDVDHSTL-VTLFKLLGYKVHVLLDQTAQEMQEKLQNFAQLPVHRVTDSCIVALL SHGVE-------GGVYGVDGK-------LLQLQEVFRLFDNANCPSLQNKPKMFFIQ--A CRGDET-DRGVDLQ--DGK-NHDRSPKCEESDASR--------------EELLKMRLPTR SDMICGYACLR--G--TAAMRNTKRGSWYVEALTQVFSE-------RA--CDMHVA---- -------DMLVKVNALIKERE---G--YAPGTEFHRCKEMSEYCS-----TLCRHLYLFP G-HPPT------------- >A_gambiae_AGAP011951-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------ECYDTSNA-RRGIALIINQVIFS------------SM AVRVGSSKDRTDI-STVLQRIGFEVRVMDDPNRKQLLSALKQLAGE-DHSHSDCLVVVVM THGKE------NNLLYASDKS--------YEANQLWEPFIGDACPSLIGKPKLFFVQ--A CRGKKL-DEGVIQA--TIS-IDSV--------------------DTQSSPGSMRYVIPAM ADLLVMYSTYD--G--HYSWRNPSKGSWFIQSLCAELGA-------SA--HCKELL---- -------HILTAVSRRVAYHY---QSNVPDNAKIDAKKQMPCMVS-----MLTKLLYLRP KK----------------- >M_musculus_ENSMUSP00000091238 ------------------------------------------------------------ -MENNKTSVDSK----SINNFEVKT----------------------------------I HGSKSVDSGIY------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------LD-SSYKMDYP-EMGICIIINNKNFH--KST-------GM SSRSGTDVDAANL-RETFMGLKYQVRNKNDLTREDILELMDSVSKE-DHSKRSSFVCVIL SHGDE-------GVIYGTNGP--------VELKKLTSFFRGDYCRSLTGKPKLFIIQ--A CRGTEL-DCGIETD--SGT-DE----------------------------EMACQKIPVE ADFLYAYSTAP--G--YYSWRNSKDGSWFIQSLCSMLKL-------YA--HKLEFM---- -------HILTRVNRKVATEF---ESF-SLDSTFHAKKQIPCIVS-----MLTKELYFYH ------------------- >P_pygmaeus_ENSPPYP00000017020 ------------------------------------------------------------ -MENTENSVDSK----SIKNLEPKV----------------------------------I HGSKSMDSGIS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------LD-NSYKMDYP-EMGLCIIINNKNFH--KST-------GM ASRSGTDVDAANL-RETFRNLKYEVRNKNDLTREEIVELMRDVAKE-DHSKRSSFVCVLL SHGEE-------GIIFGTNGP--------VDLRKITNFFRGDRCRSLTGKPKLFIIQ--A CRGTEL-DCGIETD--SGV-DD----------------------------DMACHKIPVE ADFLYAYSTAP--G--YYSWRNSKDGSWFIQSLCAMLKQ-------YA--DKLEFM---- -------HILTRVNRKVATEF---ESF-SLDATFHAKKQIPCIVS-----MLTKELYFYH ------------------- >B_taurus_ENSBTAP00000021099 ------------------------------------------------------------ -MENTENSVDSK----SIKTSETKI----------------------------------L HGSKSMDSGIS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------LE-ESYKMDYP-EMGLCIIINNKNFH--ENT-------GM CRRSPTDDSVAQX-RETFMNLKYEVRIKNDLTCKEMLELMSNVSKE-DHSKRSSFICVLL SHGEE-------GIIFGTNGP--------VNLKKLASFFRGDYCRSLTGKPKLFIIQ--A CRGTEL-DCGIETD--SGA-ED----------------------------DMACQKIPVE ADFLYAYSTAP--G--YFSWRNAKNGSWFIQALCEMLKK-------HA--HRLELM---- -------HILTRVNRKVAIEY---ESF-STDSAFHAKKQIPCIMS-----MLTKELYF-- ------------------- >C_elegans_Y48E1B.13a -----------------------------------------MVLKTIEDNCKSQFDDDLV EDFNNFQTTSSM----SSSTTISTEDFNTIEIESTFEICRSGSYTEEPILGENDEFLIDF EMERFLKFLKD-KTKQVEKRKEPFSQKEIYAVFQRRIKSELCIETVKKKFQPLLPNAIQT CEFDEET-----------------------------MIRMIYGAGIRI------------ ------------------------------------------------------------ -------------------------------------------DSVDFWNRFTSKATISL DCYSRLISY-------SSDSL--------------------------------------- ------------------------------------------------------------ --------------------------------------TLSGTHRSGFTYHWISTPPVTY HRTENKDPNIQEPSP--VEFLDVQSSLGSSMKPPILDKPTKLDDPAETRHDCSYSLEEYD SQSRMPRTDAKK----SNHKHK-YCYEMNSN-PRGTVLILSNENFK------------NM ERRVGTKQDEVNL-TKLFQKLQYTVICKRNLEAESMLEAIKEFAEM-AHT--DSIILFLL SHGDG------AGSVFGIDDM-------PVNVMEVSTYL--AYHQNLLLKPKWVAVS--A CRGGKL-NMGVPVD--GLP-ALED-----------KCAPISKFWNLMMSRIMPGTFTSLN ADVIISFSTTD--G--FTSYRDEEAGTWYIKSMCKVFNK-------HS--KTMHLL---- -------DILTETGRNVVTKY---E----NVQGNVVLKQAPEILS-----RLTKQWHFSR S-M---------------- >O_cuniculus_ENSOCUP00000006164 -------------------------------ALVESGTVGDWVTVPGEGNGYXXXXXXXX XXXXXXXXXXEQ----LDSELL--LKF-ELDYIPQRKQEPI------------------Q DALMLFQRLQE-KR-MLEENNLAFLKELLFRIHRLDL----------------------- ------------------------------------LSTLLGTSKEEMVTELQIPGRAHI SAY--------------------------------------------------------- -------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXX-------XXXXXXXXXXXXXXXX---------------------------- ------------------------------------------------------------ -------------------------------------------XXXX------------- --------------------------------------XXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXX----XXXTSE-EVYQMKSK-PRGYCLIVNNYDFS--IARREMPRHRNM KDRKGTEVDAEAL-SNTFTDLHFEVVHYNDCTAKQICDILQSYQSM-DHKDRDCFVCCIL SHGDK-------GIIYGTDGQ-------EACIYDLISYFTGSKCSSLAGKLKVFFIQ--A CQGDKY-QQAVPA---IDS-EQQS---YLD-------------------SSFPKRYVPDE ADFLLGMATVN--N--CVSYRNLFEGTWYIQSLCQSLRE-------RCP-QGEDIL---- -------SILTKVNYKVSIKE---A--------GEKKKQMPQPTF-----TLTKRLLFPL D------------------ >X_tropicalis_ENSXETP00000015203 ------------------------------------------------------------ ------------------MLGGMQKHHKDALQRLRVTLLHD------------------M IIEELVEHLVS-SG-ILTPIMHSTIMAH----RSEYK------QNVT------------- ------------------------------------LLTQLPKRGPRA------------ ------------------------------------------------------------ -----------------------------------------------FSEFCNALHATGQ RHLAEQLEE-------EAQQQQMESV------------------------------TPEV HERSFPL----PVQEST-----------------PSRPRRQ------------------- --------------------------------------FCR-EYNEE------------- --------------------------------------------------SIDDGDGPGT ----VQLCSVDF----YLSHHQ-QAYKMHSC-PRGRALIISNVAFE---TQ-------DL DHRYGGEVDVTSL-EKLFSSLGFQVEVRRNLNAQNMMSQLGAFSALPAHSALDSCVVAVL SHGLD-------GAVYGTDGK-------LVQLQDVFTAMDNAHCPQLQNKPKMFFIQ--A CRGEEA-DRGVDQR--DGR-EQSASPGCEQSDAGR---------------EDIKVRLPTQ SDMICAYACLK--G--TVSLRNTKRGSWFVQDLVSVFSQ-------YS--KNTHVA---- -------DMLVKVNALIKERE---G--HAPGTEFHRCKEMSEYCS-----TLCRDLYLFP G------------------ >C_familiaris_ENSCAFP00000032189 ---------------------------------MGEQRNTSSKELAAAEATGQSGKELEV SMENTENSVDAK----SFKNAETVI----------------------------------V ---KILKDKYL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------TK-LHYKMDYP-EMGLCIIINNKNFH--KST-------GM APRSGTDVDAANL-RETFTNLKYEVRNKNDLTCEEILELMNSVSKE-DHSKRSSFVCVLL SHGDE-------GIIFGTNGP--------VDLRKVTGFFRGDYCRSLTGKPKLFIIQ--A CRGTEL-DCGIETD--SGI-ED----------------------------DMACQKIPVE ADFLYAYSTAP--G--YYSWRNSKDGSWFIQSLCAMLKL-------YA--HKLEFM---- -------HILTRVNRKVATEF---ESF-SLDSAFHGKKQIPCIVS-----MLTKELYLYH ------------------- >A_gambiae_AGAP011950-PA ------------------------------------------------------------ ------------------------------------------------------------ -----MDSLLE-LE---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------L-QSYKTNHP-NRGIAVVINDS----------------- ENRDGWEKDLEAV-ETVLQRLKCDVRTFCDKTKHEIRDALRNVSKE-DHTKSDCLVIVAM AHGNN-------DKITLRRGE--------MHIDELWTDFVGNGCPSLIGKPKLVFIQ--S CRGNKH-DYLVGGA--AVD-AVPS------------------------PEKPICVEIPMY ADLLVMYSSYD--Q--YVSYRDKEEGSWFIQSLCQVLGA-------NI--AGKDLL---- -------TLLTHVSYLVSVRSFLMESEVNMVKRTGVLKQIPSINS-----MLTKAFYFVD K------------------ >M_domestica_ENSMODP00000036251 -----------------------------------------------------MEDNSKI KFNQQLLSINEK----LEPEEIEALKFLCSDLISPRNLEDI------------------E SGHQLFQKFMD-ED-LLNEGDYFLVAELLFLIKHHN------------------------ ------------------------------------LLQKIGYTKEKVKKEL--SSKRKI SSY--------------------------------------------------------- -------RVMLYNLSEEITTEDFEHIKFIMKEHIPKTLK----TFLSLLRHMEKQNLLSE NNLEILVNI-------CKPLSINLIKRIEQYK---------------------------- ------------------------------------------------------------ -------------------------------------------SEKGELPEFELI----- ----PYHGCGVISEQ--VSLMTFLSLLPL---FSWSRKHLPFSQQNEANNSL--EEVTGL WAQGAEGGTLFS----DMTNEA-KFYRMDHS-HRGHCIIFNNFEFQ------------TM KRRRGSCKDADEL-KSVFEWLGFTVKIHPNTEKREMEDILQQCSTSPEHRESDCFVCCVL THGES-------GSVFSSDEE-------KIAIRELTSYFKAHRCPGLANKPKLFFFQ--A CQGPDI-QESMLLE--EDAKISPP-----------------------IQVETPQRYIPVE ADFLLGMATVD--G--CCAIRHTIKGSWYIQALCHRLKC-------MVP-RNEDIL---- -------TILTEVNNDVSQLT---D-------AEGKKKQMPQPAF-----TLRKKVVFPV P-PLSP------------- >M_musculus_ENSMUSP00000031895 -----------------------------------------------MAAPSGRSQSSLH RKGLMAADRRSR----ILAVCGMHPDHQETLKKNRVVLAKQ------------------L LLSELLEHLLE-KD-IITLEMRELIQAK----GGSFS------QNVE------------- ------------------------------------LLNLLPKRGPQA------------ ------------------------------------------------------------ -----------------------------------------------FDAFCEALRETRQ GHLEDLLLT-------TLSD--IQ--------------HVLPP-------------LSCD YDTSLPF----SVCESC-----------------PPHKQLR------------------- --------------------------------------LST-DATEH------------- --------------------------------------------------SLDNGDGPPC --LLVKPCTPEF----YQAHYQ-LAYRLQSQ-PRGLALVLSNVHFT--GEK-------DL EFRSGGDVDHTTL-VTLFKLLGYNVHVLHDQTAQEMQEKLQNFAQLPAHRVTDSCVVALL SHGVE-------GGIYGVDGK-------LLQLQEVFRLFDNANCPSLQNKPKMFFIQ--A CRGDET-DRGVDQQ--DGK-NHTQSPGCEESDAGK--------------EELMKMRLPTR SDMICGYACLK--G--NAAMRNTKRGSWYIEALTQVFSE-------RA--CDMHVA---- -------DMLVKVNALIKERE---G--YAPGTEFHRCKEMSEYCS-----TLCQQLYLFP G-YPPT------------- >D_rerio_ENSDARP00000063081 ------------------------------------------------------------ ---------------------MSKKESTQRILQHKVFLIDT----------------LSV EASFILQNVQQ-AK-LITQRDYNNLSDVSERETKIIK----------------------- ------------------------------------LLDKLIGRGEET------------ ------------------------------------------------------------ -----------------------------------------------CQEFIDLLRQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------DCVLE NFPVLEGHAIFA----SSVQKV-SQYKITQN-PRGICVIINNVDFT------------SM GERRGSDEDQNYL-AKVFRWLGFEVVAHRNKTAAEMKNILQALGRT---VDGDCFVCCVL SHGVE-------EGVCGTDGS-------LVSVDEIRNPFTGVNCQKLVGKPKLFFIQ--A CRGQRK-QLRVNAQ--ADGPGDGE-------------------SEMEVDGDDFDITIPSD TDFLIARSTTD--G--HVSYRKPDEGSWFIQSLCRNLEK-------HCP-LGADIL---- -------TILLSVNNEVSIQG-------------LHSKQMPVHEV-----AMRMKLILPP V-NN--------------- >G_aculeatus_ENSGACP00000013740 ------------------------------------------------------------ --------------------CGMQERDRLALRTRSTVLCKQ------------------L VVDELLIQSLQ-TDEILTEAMAENIMAE----QTSQK------RSWR------------- ------------------------------------LLLLLPKRGPRA------------ ------------------------------------------------------------ -----------------------------------------------FSSFCSALQETEQ QHLYELLIQ-------SSEKDGKETPGMLM--------------------------CGQF IDSSLPL----PTQEVV-----------------AAK-RAR------------------- --------------------------------------TQA-ESMEF------------- --------------------------------------------------SLD-ADSPIN --SPVLPCTPDF----YLSHCH-QSYRMNSS-PRGFALVISNVTFDPCAAP-------DL DPRKGGEVDDEVL-RKVFTELDYVVKVHRDLTAQDMRTCIEEFSRRPDHRTMASCVVCLL SHGVE-------GAIYGTDGQ-------LLKLDWVFESFDNAHCPLLQNKPKMFFIQ--A CRGEEM-DCGVEQI--DGP-VRTCSPSCEQRDAGREGQGDASA---RQRGDMGRIKLPQR SDMICGFASLK--G--TAAMRNTKRGSWFVQELNKRLRL-------HA--RDTHLA---- -------DIMVQVNRHIKERE---G--YAPGTAHHRCKEMSEFTS-----SLCKDLYLFP K-YQPQ------------- >M_mulatta_ENSMMUP00000040583 ------------------------------------------------------------ ----------------------MDEADRRLLRRCRLRLVEE------------------L QVDQLWDALLS-RE-LFKPHMIEDIQRAGSG--SRRD------QARQ------------- ------------------------------------LITDLETRGSQA------------ ------------------------------------------------------------ -----------------------------------------------LPSFISCLVDTGQ DMLASFLRT--------------------------------------------------- ------------------------------------------------------------ -------------------------------------NRQAVKL---------------- --------------------SKPTLENLTPVVL-----RPEIRKPEVLR-PETPRPVDIG SGGCGDVGAPES----LRGNAD-LAYVLSME-PCGHCLIINNVNFC--RES-------GL STRTGSSIDCEKL-QRRFSLLHFMVEVKHDLTAKEMVLALLELARR-DHSALDCCVVVIL SHGCQASHLQFPGAVYGTDGC-------PVSVERIVNIFNGTSCPSLGGKPKLFFIQ--A CGGEQK-DHGFEVA--STS-PEDESSGSNPEPDATPFQEDLRTF----DQLDAVSSLPTP SDIFVSYSTFP--G--FVSLRDPKSGSWYIETLDNIFEQ-------WA--HSEDLQ---- -------SLLLRVADAVSVKG--------------IYKQMPGCFN-----FLRKKLFFKT S------------------ >E_caballus_ENSECAP00000003321 -----------------------------------------------MAAPSAPSLPALQ QKGLMAADRGRR----ILGVCGMHPDHQEALKKNRVVLAKQ------------------L LLSELLEHLLE-KD-IITLEMRELIQAK----VTSFG------QNVE------------- ------------------------------------LLNLLPKRGPQA------------ ------------------------------------------------------------ -----------------------------------------------FEAFCVALRETKQ GHLEDLLLT-------TLSG--LQ--------------HVLPP-------------LSCD YDLSLPF----PVCESC-----------------PPHKQLR------------------- --------------------------------------LST-DTVEH------------- --------------------------------------------------SLDNGDGPPC --LQVKPCTPEF----YQAHYQ-LAYRLQSR-PRGLALVLSNVHFT--GEK-------DL EFRSGGDVDHSTL-VTLFKLLGYNVHVLLDQTAKEMQEKLQNFAQLPAHRVTDSCIVALL SHGVE-------GGIYGVDGK-------LLQLQEVFRLFDNANCPSLQNKPKMFFIQ--A CRGDET-DRGVDQQ--DGK-NHAKSPECEESDAGK--------------EELLKMRLPTR SDMICGYACLK--G--TAAMRNTKRGSWYIEALTQVFSE-------RA--CDMHVA---- -------DMLVKVNALIKERE---G--YAPGTEFHRCKEMSEYCS-----TLCRHLYLFP G-HPPT------------- >A_carolinensis_ENSACAP00000006831 ------------------------------------------------------------ ----------SR----MLGVCGMQKCHQEALKKNRVSLAKQ------------------L VLKELMEHLIE-KD-VITEEMMEMIQAK----AGNFS------QNIE------------- ------------------------------------FLNLLPKRGPKA------------ ------------------------------------------------------------ -----------------------------------------------FSAFCEALRETKQ PHLEEMLLL-------NLIDFLLFHHV-----------------------------IVPP QNAHLPL------HTVCDLL--------------PFAYQLF------------------- --------------------------------------ISSAEPMEH------------- --------------------------------------------------SLDDGDGPHY --PQVMPCTPEF----YRTHEQ-LAYKLKSQ-PRGLALILSNIHFN--KET-------DL DFRSGGDVDNTAL-HMLFKHLGYQVVVRQDRTAQEMKEELEIFSKHPAHRNVDSCIVSLL SHGIE-------GGIYGIDGK-------LLQLQEIFRLFDNANCPNLQNKPKMFFVQ--A CRGDET-DHGVDQI--DGN-DRASSPGCEETDANK--------------KENPKLRLPTC SDMICGYACLK--G--TAAMRNTKHGSWYVEALTSVFAE-------DS--GHMHVA---- -------DMLVKVNRLIKLRE---G--HAPGTEFHRCKEMSEYCS-----TLCQDLYLFP G-YFPG------------- >T_guttata_ENSTGUP00000006879 ------------------------------------------------------MTDIGD GAHLGKDLADTK----SIPGFKGKN----------------------------------L PASKSMDSGIL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PD-YSYRMDYP-EMGECIIINNKNFH--RYT-------GM SPRSGTDADAASV-REVFMKLGYKIKINNDLSCEGIFNLLKNVSEE-DHSKRSSFVCVLL SHGDE-------GLIYGTDGP--------LELKALTSLFRGDRCRSLAGKPKFFFIQ--A CRGTEL-DSGIETD--SGS-EE-----------------------------TMCQKIPVE ADFLYAYSTAP--G--YYSWRNSAEGSWFIQSLCKMLKE-------HA--RKLELM---- -------QILTRVNRRVA-EY---ESC-STRQDFNAKKQIPCIVS-----MLTKEFYFPS ------------------- >D_rerio_ENSDARP00000071815 ---------------------------------------------------------MSD VKPKGVDTVDAR----QSDAKESSSVT--------------------------------D PGLVQMDAKSH------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------SDDNVD-YQYKTNYP-NLGQCLIINNKNFH--KRT-------GM GVRNGTDEDAKKV-FETFSQLGFKVGHYNDLTVSQMMALLNKASQE-DHSKSAMFACVLL SHGDD-------GLIYGTDNS--------IELKRLFAHFRGDRCTSLVGKPKLFFIQ--A CRGTDL-DSGIECD--GVG-DE------------------------------ETQRIPVE ADFLYAYSTAP--G--YYAWRNVANGSWFISSLCDMLLK-------YG--KQLEIM---- -------QVMTRVNHKVALEF---ESS-SNLPGFDGKKQIPCIVS-----MLTKELYFPK ------------------- >M_mulatta_ENSMMUP00000015808 ------------------------------------------------------------ -MENTENSVDSK----SIKSLEPKI----------------------------------I HGSKSVDSGIS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------LE-NSYKMDYP-EMGLCIIINNKNFH--KST-------GM ASRSGTDVDAANL-RETFINLKYEVRNKNDLTREEIVELMRNVSKE-DHSKRSSFVCVLL SHGEE-------GIIFGTNGP--------LDLKKITSFFRGDCCRSLTGKPKLFIIQ--A CRGTEL-DCGIETD--SGV-ED----------------------------DMACHKIPVE ADFLYAYSTAP--G--YYSWRNSKDGSWFIQSLCAMLKQ-------YA--DKLEFM---- -------HILTRVNRKVATEF---ESF-SLDATFHAKKQIPCIVS-----MLTKELYFYH ------------------- >D_melanogaster_FBpp0084848 ------------------------------------------------------------ ---------------------MDATNNGESADQVGIRVGNP------------------E QPNDHTDALGS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------VGSGGAGSSGLVAGSSHPYGSGAIGQLANGYSS PSSSYRKNVAKM----VTDRHA-AEYNMRHK-NRGMALIFNHEHFE--VP--------TL KSRAGTNVDCENL-TRVLKQLDFEVTVYKDCRYKDILRTIEYAASQ-NHSDSDCILVAIL SHGEM-------GYIYAKDTQ--------YKLDNIWSFFTANHCPSLAGKPKLFFIQ--A CQGDRL-DGGVTMQ--RSQ-TETD------------------------GDSSMSYKIPVH ADFLIAYSTVP--G--FYSWRNTTRGSWFMQSLCAELAA-------NG--KRLDIL---- -------TLLTFVCQRVAVDF---ESCTPDTPEMHQQKQIPCITT-----MLTRILRFSD KQLAPAGRV---------- >O_latipes_ENSORLP00000010095 ----------------------------------------------------------MA SNRPGEDSTDAR----KDNGELAAGASPAP-----------------------------D RMDVDGKPSSH------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------S-FRYSLNFP-TIGLCIIINNKNFD--RGT-------GM NQRNGTDIDAASA-MKVFSKLGYRVKIYNDQTVKQIKQLLTDVSRM-DHSDSASFVCILL SHGDE-------GVFFGTDGS--------IELKTLTSLFRGDHCKSLVGKPKLFFIQ--A CRGTEL-DDGIEAD--SKE-D--------------------------------TTKIPVE ADFLYAFSTAP--G--YYSWRNTMTGSWFINSLCEMLSK-------YG--KELELL---- -------HIMTRVNHMVAVEF---ESI-STLPGFHAKKQIPCIVS-----MLTKEMYFYP ------------------- >G_aculeatus_ENSGACP00000022402 ----------------------------------------------------------MS VNGPGEDRTDAK----TEQSEVSSSAS--------------------------------A PEEVDAKPNVH------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------S-FRYSLSFP-SIGQCIIINNKNFD--RGT-------GM NQRNGTDVDAANA-MKVFGNLGYKVKVYNDQSVAQIQHVLTSVSKQ-DHSCSASFVCVLL SHGDG-------DLFFGTDGP--------VPLKSLTSLYRGDRCKSLVGKPKLFFIQ--A CRGTEL-DPGIEAD--SVK-DE-------------------------------TTRIPVE ADFLYAFSTAP--G--YYSWRNTTTGSWFMQSLCDMISK-------YG--KELELQ---- -------HIMVRVNHKVAVAF---ESV-SNSPDFNARKQIPCVVS-----MLTKEMYFSP ------------------- >O_latipes_ENSORLP00000015114 ------------------------------------------------------------ ----------RS----VTQKCGMQKRDAEALRNCSVCLLKD------------------L VVDELLIQALV-KDGILTQNMAESIMVQ----KTSHH------RSFK------------- ------------------------------------LLLLLPKRGPRA------------ ------------------------------------------------------------ -----------------------------------------------FKSFCSALKETEQ EHLCDLLTQEEEGREVCLDTPLINSE------------------------------EQSE VSSSMSY----PIHDSE-----------------GLQLEMR------------------- --------------------------------------TNT-ESMES------------- --------------------------------------------------SLD-ADSPIN --TPVLACSADF----YLSHCQ-QSYRMNSS-PRGSVLVISNINFDPRAAP-------EL DPRKGGEVDDEVL-RKLFTELDYSVNFHRDLTAQDMKMVIENFCRRPDHQKVDSCVVCLL SHGVD-------GAIYGTDGQ-------QLALDWVFEAFDNAHCPLLQNKPKMFFIQ--A CRGDEM-DCGVEQI--DGP-ARTFSPTCEQRDAGREEQGDADG-RQRASTGRQRIKLPQR SDMICGFASLK--G--TAAMRNTKKGSWFIQELNTALRL-------NA--RDTHLA---- -------DILVQVNKRIKERE---G--YAPGTAHHRCKEMSEFTS-----SLCKDLYLFP K-YQPQC------------ >A_gambiae_AGAP011952-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------ENYDTSHR-NRGTALIFNHVNFE------------SN AKREGSNKDRDEI-KKELLQLGFDARVFNDLKKQELLAKLDEVAKE-DHTESDCFVLVMM THGQD-------GSLYAADKQ--------YQIAELWEPFVGDACKTLIGKPKLFFVQ--A CRGTKF-DKGVKLT--KIA-TDTV--------------------DALSSSSQRTCVIPTM ADVLVMYSAFD--G--HYSWRNPTHGSWFIQSLSIELNQ-------HA--HRKELL---- -------QLLTSVSRRVAYLY---ESNVPGNEQMDGKKQMPCVVS-----MLTKALYFPR K------------------ >T_guttata_ENSTGUP00000010625 ------------------------------------------------------------ DFRKLLFEVSEA----LVTEELSALKFLSLDHVPRRKLEAI------------------H EPKAFFEVLQE-KD-MIGAGNLFFLKELLYRIHRIDL----------------------- ------------------------------------LSTPLGCSREEMERELQLPGRAQV SAY--------------------------------------------------------- -------RQLLYGIAEDLTSEDVRSVKFLLQKQLPKNKLQENASMLQVFLEMEIKGIIKE DNMTTLKDI-------LQRFRADIKKKIDAYE---------------------------- ------------------------------------------------------------ -------------------------------------------EKKKGLTGSAE------ -------------------------------------------VSLELPVSWIDSVDHIK QSTLGLPGEDRS----LSFQLL-EAYKMTSR-PCGVCLILNNHNFA--KAREGVLEHKHM KDRNGTDVDAAAL-RNVFSKLHFRVEEYRDLTAEEIRETVNIFQSA-DHEDKDCFVCCIL SHGKK-------GIIYGVDGQ-------EVPIRELTTSFTAQNCSSLAGKPKVFFIQ--A CQGDAF-HKGVAIE--TDS-VEEDSSLERD-------------------ARFQLDCIPAE ADFLLGMATLQ--D--YVSYRSPKEGTWYIQALCQHLEY-------SCP-RGEDVL---- -------TILTAVNQEVSKKT---C-------ERDAKKQMPQPSF-----TLRKRLIFPV N------------------ >C_elegans_Y73B6BL.7 --------------------MKIGWLLITICSGIITKCINAHSSPYQNANESAIDDAYFL VLIIPAVSVAIV----LVVVIFLCCPRQQIRSDNVIKLEEGVNDVIEENVTHVVSLREAK VSGMMTDLTRF-RQEIFTKHLTFNSNPESIDAATKNV------QNVKQSLDTWRDRIKER LDEIDRLCTEEGDSLTPEQYSALREMRRQLADEYDTVLRTVEGIHTRLNILSALLIEFSS VTSSMQSWMTDRARLAGDIRHKSGDPMRVDEARFEAKSLMDEVVREESRLKTIGASVLKI EQEISAMRDDVRASRSTDDVGISMDEVYEKRRRVEVDYMQLLRQCQDLISLQIRLHAMND EHAEQARRA-------EGWLQMLKNDVAGVAKDPRFKKDEDLIERDEELNRMAAGGSGGP TSRQLAMREKIEQREREEEEWRRKAKEKFEEEAAKNRARERKWAEEHGFNRPIRTRSQKY AEQDRIRYARKKAALEQSNEQSNESTDDAVESDSDDVPAPQSPPTPSPADPGPTTSSSSL TQDPASNATGFSDVP--APQAPPTPSPADPGPTTSSSSLTQDPASNATGFSGSSPPNSFE ETRMMCEDASDG----KKIDET-RKYRNNRS-SKCRAIIINNVVFC------------GM EKRIGSDKDKKKL-SKLFERLGYQSTSYDNLKSSEILETVRQFTQS-NHG--DSLIITIM SHGDQ-------GLLYGVDGV-------PVQMLDIIDLM---CTASLAKKPKWLMCV--C CRGDRI-DRAVRCD--GFI-DN-------------FFDRFPKFFQFMKSKFPSHQTSSSQ ADLLVSFSTSP--G--FLSFRDETKGTWYIQELYRVIIE-------NA--KDTHLA---- -------DLLMETNRRVVEKY---E----ADKVVIVCKQAPEFWS-----RFTKQLFFDV ------------------- >D_rerio_ENSDARP00000072390 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------A-FEPYKKHK-NIGKCLIISNEHFP--VQF-------SL NRKKGNSVDERRL-SSTFKSLGFHVKVENNLSANQMIDALRTVSEE-DHTDNSCFVCVLM SHGEE-------GTILGSDER-------WIPVKTLTSLLTSDLCPSLRDKPKIFFLQ--A CRGVEY-DPGVEAD--SVE-AS--------------------------EDFFGISDVP-E LDFLCCYSTVE--G--YFAWRNPETGSIFIRELCKTLMD-----------CRLEII---- -------QILTRVNHLVAYYF---QSY-TLELETNRKRQMPCFAS-----RLTKDFYLHV ------------------- >T_rubripes_ENSTRUP00000040691 ------------------------------------------------------TNMSAN GPSPGGDFTDAK----KGAGQQPRSGSSS------------------------------G RVTVDAKPAAY------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------S-FRYSLDFP-NMGHCIIINNKNFD--RRT-------GM NTRNGTDVDAANA-MKVFLSLGYKVKVHNDQTVNQMKQLLVSAAEE-DHSACASFVCVLL SHGDE-------GVFFGTDGS--------VELKYLTSLFRGDRCKSLVGKPKLFFIQ--A CRGNDL-DGGIETD--SAA-DS------------------------------STTKIPVE ADFLYAFSTAP--G--YYSWRNTTSGSWFMQSLCDAISK-------YG--KELELQ---- -------HILTRVNHKVAVDF---ESV-SNLPGFDAKKQIPCIVS-----MLTKEMYFS- ------------------- >D_melanogaster_FBpp0071971 ------------------------------------------------------------ ----------------------MTDECVTRNYGVGIRSPNG------------------S ENRGSFIMADN------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------TDAKGCTPESLVVGGATAAS------------- -PLPANKFVARM----PVERYA-SEYNMSHK-HRGVALIFNHEFFD--IP--------SL KSRTGTNVDAQEL-KKAFENLGFAVSVHKDCKLRDILKHVGKAAEL-DHTDNDCLAVAIL SHGEH-------GYLYAKDTQ--------YKLDNIWHYFTATFCPSLAGKPKLFFIQ--A CQGDRL-DGGITLE--KGV-TETD------------------------GESSTSYKIPIH ADFLFSYSTIP--G--YFSWRNINNGSWYMQSLIRELNA-------NG--KKYDLL---- -------TLLTFVNQRVALDF---ESNVPATPMMDRQKQIPCLTS-----MLTRILRFGD KPNGNKAG----------- >A_gambiae_AGAP012945-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------E-DHKNSDCLLVVIM THGDD-------DVLHAKDGT--------FNVDRLWENFIGDSCPSLLGKPKLFFIQ--A CRGSSF-DTGVHFS--QCM-TQVA------------------------KTSSIQYAIPSM ADLLVMYSTYK--G--HYSWRNPSTGSWFIRALCDELRE-------HG--NSKELL---- -------QLLTSVSRRVAYEF---QSNVPN------------------------------ ------------------- >G_gorilla_ENSGGOP00000001932 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RAGSG--SRRD------QARQ------------- ------------------------------------LIIDLETRGSQA------------ ------------------------------------------------------------ -----------------------------------------------LPLFISCLEDTGQ DMLASFLRT--------------------------------------------------- ------------------------------------------------------------ -------------------------------------NRQAAKL---------------- --------------------SKPTLENLTPVVL-----RPEIRKPEVLR-PETPRPVDIG SGGFGDVGALES----LRGNAD-LAYILSME-PCGHCLIINNVNFC--RES-------GL RTRTGSNIDCEKL-RRRFSSLHFMVEVKXXXXXXEMVLALLELARQ-DHGALDCCVVVIL SXGCQXXXXQFPGAVYGTDGC-------PVSVEKIVNIFNGTSCPSLGGKPKLFFIQ--A CGGEQK-DHGFEVA--STS-PEXESPGSNPEPDATPFQEGLRTF----DQLDAISSLPTP SDIFVSYSTFP--G--FVSWRDPKSGSWXVETLDDIFEQ-------WA--HSEDLQ---- -------SLLLRVSAAFLCKG--------------EGRLLRGSVSSWGWGFGVSRAGPNQ G------------------