10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0076078 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP005410-PC ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL006743-PA ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000046985 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000095595 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000095601 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000027844 HP---------------------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000018147 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000286794 HP---------------------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000012626 HP---------------------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000028702 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000011405 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000057336 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000025463 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000008862 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000359032 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000040755 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000023349 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013004 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000009559 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000044568 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000039218 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000033763 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000017477 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000035248 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000008706 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000002776 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000014446 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012021 ------------------------------------------------------------------------------------------------------------------------ C_elegans_K07H8.3 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000013819 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000000964 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000056134 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000004594 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000049533 TD---------------------------------------------------------------------------------------------------------------------- S_cerevisiae_YHR013C ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000015789 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000038636 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0074532 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000057699 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013627 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000007989 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001522 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000335636 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000020525 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000012011 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000022806 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000021581 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000005151 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000015667 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000021531 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP001878-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL009373-PA ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010421 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000004164 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000039378 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000002805 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000014047 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000010800 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000007334 ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y97E10AL.3 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010124 ------------------------------------------------------------------------------------------------------------------------ S_cerevisiae_YPR131C ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0080059 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0080033 ------------------------------------------------------------------------------------------------------------------------ S_cerevisiae_YPR051W ME---------------------------------------------------------------------------------------------------------------------- A_gambiae_AGAP003917-PA LP---------------------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000018747 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL012413-PA ME-----------------------------------VKTEENVAPQANGLEAVVGKSGKKKAKRKNRSKNIATNACQEEHHTPQEEEEGDNGITSGKQNGIT----------------- M_domestica_ENSMODP00000009636 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000000646 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000019734 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000022463 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010635 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000020074 MAEVPPGPSSLLPPPAP---AAPAAAELRCPFPAGAALACCSE--DEEDDEEHE--GGCGSPAGGEAAT-AAKARSCLRCPQLPQEQQQQLNGLIGPELRHLRAAGTLKSK--------- H_sapiens_ENSP00000298406 MAEVPPGPSSLLPPPAP---PAPAAVEPRCPFPAGAALACCSE--DEEDDEEHE-GGGSRSPAGGESATVAAKGHPCLRCPQPPQE-QQQLNGLISPELRHLRAAASLKSK--------- P_troglodytes_ENSPTRP00000010832 MAEVPPGPSSLLPPPAP---PAPAAVEPRCPFPAGAALACCSE--DEEDDEEHE-GGGSRSPAGGESATVAAKGHPCLRCPQPPQE-QQQLNGLISPELRHLRAAASLKSK--------- D_melanogaster_FBpp0072598 MG---------------------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000028074 MAEVPPGPSSLLPPPAP---PAPAAAEPHCPFPAGAALACCSE--DEEDDEEHEGGGGGRSPAGGESATVATKGHPCLRCPQPPQE-QQQLNGLISPELRHLRAAASLKSK--------- P_pygmaeus_ENSPPYP00000006647 MAEVPPGPSSLLPPPAP---PAPAAVEPRCPFPAGAALACCSE--DE--------------------------------------E-QQQLNGLISPELRHLRAAASLKSK--------- T_guttata_ENSTGUP00000013437 -----------------------------------------------------------------------------------PPHHNHQLNGLISPELRHLRASLKGKIL--------- X_tropicalis_ENSXETP00000026216 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000017282 MAEVPPGPSSLLPPPAP---SASAAAEPRCPFSAGAALACCSE--DEEDDEEHEGGGCGGSPAGGEA---AAKGHPCLRCPQPPQE-QLQLNGLINPELRHLRAAASLKSK--------- M_musculus_ENSMUSP00000041450 MAEVPPGPSSLLPPPAP---AAPAAAELRCPFPAGAALACCSE--DEEDDEEHE--GGCGSPAGGEAATSAKARSCLRCPQLPPEQQQQQLNGLIGPELRHLRAAATLKSK--------- D_melanogaster_FBpp0070203 MA------DAQAAAAGKKKYKNKKNSAEKNPNHNPNSSGQVEAQTPSNGHVQHQEEEATEDQEPAQELRGLLKKMHLCNGHGHKEQEARPLGEVVNGHAHGHSNNNHIRCT--------- C_intestinalis_ENSCINP00000010530 MDRC-----------------------------DGNASVPFNTNLEQVIRAGYTGGNGVTSNCKERNTSVCLKNGNAKINKGHCDKMSNNLQFTMKCSSSTRTDCPNSNST--------- G_aculeatus_ENSGACP00000016825 M----------------------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000004980 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000018946 MATVPPGPSEALLASPADSHPFSGDRSAQPVVEDGQPPCLANDCVSAGTRDESHPLNDVKRSVKRKQKGMLTQTSPAVLHLKPQSG-EQQLNGVVSPSEEPDVRPESLRSP--------- C_elegans_B0238.10 MA---------------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000029061 MATVPPGPSSALPASPADISPFPTAGNVEAAEEDGEPACRREE--RGFISTGKKSVSEVKTSLKNKKKNMLARSSPAALHLKIQAREQQQLNGLASPSEDDDSHQHSGNRPDNPRPSLDN O_cuniculus_ENSOCUP00000013296 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000010234 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000018738 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000022643 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000006601 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000051155 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000020661 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000039993 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000023856 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000021826 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000240922 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015136 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000013754 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0087227 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000011435 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000015737 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000032139 ------------------------------------------------------------------------------------------------------------------------ 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0076078 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP005410-PC ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL006743-PA ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000046985 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000095595 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000095601 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000027844 -------------------------------------------------------------------------------------------------------------ASTRFSPVVLA T_nigroviridis_ENSTNIP00000018147 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000286794 -------------------------------------------------------------------------------------------------------------PSTRFSPVVLA G_gorilla_ENSGGOP00000012626 -------------------------------------------------------------------------------------------------------------ASTRFSPVVLA C_familiaris_ENSCAFP00000028702 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000011405 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000057336 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000025463 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000008862 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000359032 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000040755 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000023349 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013004 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000009559 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000044568 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000039218 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000033763 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000017477 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000035248 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000008706 ---------------------------------------------------------------------------------------------------------------------HPT R_norvegicus_ENSRNOP00000002776 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000014446 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012021 ------------------------------------------------------------------------------------------------------------------------ C_elegans_K07H8.3 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000013819 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000000964 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000056134 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000004594 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000049533 -------------------------------------------------------------------------------------------------------------IISSVEVAQGR S_cerevisiae_YHR013C ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000015789 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000038636 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0074532 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000057699 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013627 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000007989 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001522 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000335636 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000020525 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000012011 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000022806 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000021581 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000005151 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000015667 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000021531 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP001878-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL009373-PA ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010421 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000004164 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000039378 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000002805 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000014047 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000010800 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000007334 ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y97E10AL.3 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010124 ------------------------------------------------------------------------------------------------------------------------ S_cerevisiae_YPR131C ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0080059 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0080033 ------------------------------------------------------------------------------------------------------------------------ S_cerevisiae_YPR051W ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP003917-PA ------------------------------AEESPSAVDAISKKLEQCVQIGLNGL-TNG---LPSARSEEANGGVTSLPPTHKDTPGRKKARSRATKKGHASTTDEGGDCAGHGNAKTD O_anatinus_ENSOANP00000018747 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL012413-PA ------------------------------QDEQESSVENVCQKLEQSLKLGKNGL-TNG---TLSEAEHH--HQVAKLEPTATTGKKKHKRHKNKSQSSTAVSGSEPVNCEPPSKSETS M_domestica_ENSMODP00000009636 ---------------------------------------------------------------------------------------------------------------------E-D A_carolinensis_ENSACAP00000000646 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000019734 ---------------------------------------------------------------------------------------------------------------------E-E C_familiaris_ENSCAFP00000022463 ---------------------------------------------------------------------------------------------------------------------E-D E_caballus_ENSECAP00000010635 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000020074 ------------------------------VLSAAEAAA----PDGAPKVTATKGA-EGH---PGERPPHSVPNNARTALPGRPEAAAAAAAGAASDPATSRNGLVEGNE--Q-EEEE-D H_sapiens_ENSP00000298406 ------------------------------VLSVAEVAATTATPDGGPRATATKGA-GVH---SGERPPHSLSSNARTAVP------SPVEAAAASDPAAARNGLAEGTE--QEEEEE-D P_troglodytes_ENSPTRP00000010832 ------------------------------VLSVAEVAATTATPDGGPRATATKGA-GVH---SGERPPHSLSNNARTAVP------SPVEAAAASDPAAARNGLAEGTE--QEEEEE-D D_melanogaster_FBpp0072598 ----------------------------------------------------------------------------------------------DALPEAVLI------------QKELS M_mulatta_ENSMMUP00000028074 ------------------------------VLSVAEVAATTATPDGGPRATATKGA-GVH---SGERPPHSLSNNARTAVP------SPAEAAAASDPAAARNGLAEGTE--QEEEEE-D P_pygmaeus_ENSPPYP00000006647 ------------------------------VLSVAEVAATTATPDGGPRATATKGA-GVH---SGERPPHSL-SNARTAVP------SPAEAAAASDPAAARNGLAEGTE--QEEEEE-D T_guttata_ENSTGUP00000013437 ------------------------------------GSEAGAAPEGLENKRASKTMGSGQ---QQPSPPSAAPCSQPAATTATAAAKTAARNGLAGETGLEEEEQEEGDE---GGEEE-E X_tropicalis_ENSXETP00000026216 -------------------------------------------------------------------------------------------------------------------EEE-E B_taurus_ENSBTAP00000017282 ------------------------------VLSSAEAATIAATPDGGPRATATKGA-GVH---SGESPPHCLPSNARTALS------SPAEAAAASDPAAARNGLAEGTE--Q-EEEE-D M_musculus_ENSMUSP00000041450 ------------------------------VLSAAEAAA----PDGASKVTATKGA-EGH---PGERPPHSVPNNARTALPGRSEA-AAAAAGAASDPAAARNGLVEGTE--QQEEEEMD D_melanogaster_FBpp0070203 ----------------------SGSSNNNNSTHNNNSVDSSNNNRKQRREGGDGGGSDSNSLKPEEKPITATSKTTANIHPTTTTDPKPKVSEDVAVEQGVHVATGSGHSREQERKQPPS C_intestinalis_ENSCINP00000010530 -------------NCFKNPKNHVHGNYQKTHEEKETTKPDVSGEDNQVKYTSAEGM-TDG---LENNNIKSLINNEQHLQP----------------------------D--QHCTQDMS G_aculeatus_ENSGACP00000016825 -----------------------------------------------PGFTRTEGDDGGR---PGVEGGHES---------------DPEEPPSDGPPEAGPGGRRGRAD--PQEPPA-A T_nigroviridis_ENSTNIP00000004980 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000018946 --------------------ADTDSGDGAPAEREGPVSENGAHLNGMPDFSRSEAARGAD---KHKQP--------------------SRPPGHESPDAAGPGGEESSSD-----PPA-A C_elegans_B0238.10 --------------------------------------------------IGVQKKTSTPLDVGTEQEPTNLEKTIGTLRRCLQIAGTSNKPGSRSAKNSISE---------ESNDLTME T_rubripes_ENSTRUP00000029061 CDSGSGACNDDMSSVKYNSEHFQHEGHSPFSKNGSHSPLVNNSMNGVPGLTRTEGA-HGR---SGEDGKEDIFDHPEAPRP----------PSVKTQEATGPGGVSPDND--PQQPLS-A O_cuniculus_ENSOCUP00000013296 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000010234 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000018738 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000022643 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000006601 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000051155 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000020661 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000039993 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000023856 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000021826 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000240922 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015136 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000013754 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0087227 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000011435 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000015737 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000032139 ------------------------------------------------------------------------------------------------------------------------ 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0076078 ---------------------------------MNIRCAK--PEDLMTM----------------------------QHCNLLCLPENYQMKYYFYHGLTWPQLSYVA------------ A_gambiae_AGAP005410-PC ---------------------------------MNIRCAK--PEDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLTWPQVSYVA------------ A_aegypti_AAEL006743-PA ---------------------------------MNIRCAK--PEDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLTWPQLSYVA------------ X_tropicalis_ENSXETP00000046985 ---------------------------------MNIRNAR--PEDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWPQLSYIA------------ D_rerio_ENSDARP00000095595 ---------------------------------MNIRNAR--PEDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWPQLSYIA------------ D_rerio_ENSDARP00000095601 ---------------------------------MNIRNAR--PEDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWPQLSYIA------------ P_troglodytes_ENSPTRP00000027844 PWTRFLRQTVPLKVGDSLFWIHCSPTGSLRSAIMNIRNAR--PDDLMNM----------------------------QHCNLLCLPENYQMKYYLYHGLSWPQLSYIA------------ T_nigroviridis_ENSTNIP00000018147 ---------------------------------MNIRNAR--PEDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWPQLSYIA------------ H_sapiens_ENSP00000286794 PWTRFLRQTVPLKVGDSLFWVHCSPTGSLPSAIMNIRNAQ--PDDLMNM----------------------------QHCNLLCLPENYQMKYYLYHGLSWPQLSYIA------------ G_gorilla_ENSGGOP00000012626 PWTXFLRQTVPLKVGDSLFWVHCSPTGSLPSAIMNIRNAR--PDDLMNM----------------------------QHCNLLCLPENYQMKYYLYHGLSWPQLSYIA------------ C_familiaris_ENSCAFP00000028702 -----------------------------PAAVMNIRNAR--PEDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWPQLSYIA------------ G_aculeatus_ENSGACP00000011405 ---------------------------------MNIRNAR--PEDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWPQLSYIA------------ M_musculus_ENSMUSP00000057336 ---------------------------------MNIRNAR--PDDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWPQLSYIA------------ M_musculus_ENSMUSP00000025463 ---------------------------------MNIRRAR--PDDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWPQLSYIA------------ O_latipes_ENSORLP00000008862 ---------------------------------MNIRNAR--PEDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWPQLSYIA------------ H_sapiens_ENSP00000359032 ---------------------------------MNIRNAR--PEDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWPQLSYIA------------ M_mulatta_ENSMMUP00000040755 ---------------------------------MNIRNAR--PEDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWPQLSYIA------------ P_pygmaeus_ENSPPYP00000023349 ---------------------------------MNIRNAR--PEDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWPQLSYIA------------ E_caballus_ENSECAP00000013004 ---------------------------------MNIRNAR--PEDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWPQLSYIA------------ G_gorilla_ENSGGOP00000009559 ---------------------------------MNIRNAR--PEDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWPQLSYIA------------ R_norvegicus_ENSRNOP00000044568 ---------------------------------MNIRNAR--PEDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWPQLSYIA------------ T_rubripes_ENSTRUP00000039218 ---------------------------------MNIRNAR--PEDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWPQLSYIA------------ M_musculus_ENSMUSP00000033763 ---------------------------------MNIRNAR--PEDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWPQLSYIA------------ B_taurus_ENSBTAP00000017477 ---------------------------------MNIRNAR--PDDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWPQLSYIA------------ M_mulatta_ENSMMUP00000035248 ---------------------------------MNIRNAR--PDDLMNM----------------------------QHCNLLCLPENYQMKYYLYHGLSWPQLSYIA------------ O_cuniculus_ENSOCUP00000008706 STPSSAAAAPTEGQRQTVGLGACASPPFSRAATMNIRNAR--PDDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWPQLSYIA------------ R_norvegicus_ENSRNOP00000002776 ---------------------------------MNIRNAR--PEDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWPQLSYIA------------ M_domestica_ENSMODP00000014446 ---------------------------------MNIRNAR--PEDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWPQLSYIA------------ A_carolinensis_ENSACAP00000012021 ---------------------------------------Q--PEDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWPQLSYIA------------ C_elegans_K07H8.3 ---------------------------------MNIRCAR--VDDLMSM----------------------------QNANLMCLPENYQMKYYFYHALSWPQLSYIA------------ C_intestinalis_ENSCINP00000013819 ---------------------------------MNIRNST--PADLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWPQLSYVA------------ O_cuniculus_ENSOCUP00000000964 ---------------------------------MNIRNAR--PEDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWP-XXXXX------------ R_norvegicus_ENSRNOP00000056134 ----------------------CGLTGGFSAANMNICWTR--PYDLMNI----------------------------QHCNLLCLPENYQMKYY-YHGLSWP-LSYIA------------ O_anatinus_ENSOANP00000004594 ---------------------------------MNIRNAR--PEDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWPQLSYIA------------ R_norvegicus_ENSRNOP00000049533 TYLGYENTMSLYVGNFIMFIFCSPCLVGLSAANMNICWTR--PYDLMNI----------------------------QHCNLLCLPENYQMKYY-YHGLSWP-LSYIA------------ S_cerevisiae_YHR013C -------------------------------MPINIRRAT--INDIICM----------------------------QNANLHNLPENYMMKYYMYHILSWPEASFVATTTTLDCEDSDE T_guttata_ENSTGUP00000015789 ---------------------------------MNIRNAR--PEDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWPQLSYIA------------ P_troglodytes_ENSPTRP00000038636 ---------------------------------MNIRNAR--PEDLMNM----------------------------QHCNLLCLPENYQMKYYFYHGLSWPQLSYIA------------ D_melanogaster_FBpp0074532 --------------------------------MTTLRPFT--CDDLFKF----------------------------NNVNFDPLTETYGLSFYTQYLAKWPEYFQLA------------ D_rerio_ENSDARP00000057699 --------------------------------MTTLRAFT--CDDLFKF----------------------------NNINLDPLTETYGIPFYLQYLAHWPEYFIVA------------ T_nigroviridis_ENSTNIP00000013627 --------------------------------MTTLRPFT--CDDLFKF----------------------------NNINLDPLTETYGIPFYLQYLAHWPEYFIVA------------ C_familiaris_ENSCAFP00000007989 --------------------------------MTTLRAFT--CDDLFRF----------------------------NNINLDPLTETYGIPFYLQYLAHWPEYFIVA------------ B_taurus_ENSBTAP00000001522 --------------------------------MTTLRAFT--CDDLFRF----------------------------NNINLDPLTETYGIPFYLQYLAHWPEYFIVA------------ H_sapiens_ENSP00000335636 --------------------------------MTTLRAFT--CDDLFRF----------------------------NNINLDPLTETYGIPFYLQYLAHWPEYFIVA------------ G_gallus_ENSGALP00000020525 --------------------------------MTSLRAFT--CDDLFRF----------------------------NNINLDPLTETYGIPFYLQYLAHWPEYFIVA------------ P_pygmaeus_ENSPPYP00000012011 --------------------------------MTTLRAFT--CDDLFRF----------------------------NNINLDPLTETYGIPFYLQYLAHWPEYFIVA------------ P_troglodytes_ENSPTRP00000022806 --------------------------------MTTLRAFT--CDDLFRF----------------------------NNINLDPLTETYGIPFYLQYLAHWPEYFIVA------------ O_latipes_ENSORLP00000021581 --------------------------------MTTLRPFT--CDDLFKF----------------------------NNINLDPLTETYGIPFYLQYLAHWPEYFIVA------------ A_carolinensis_ENSACAP00000005151 --------------------------------MTSLRAFT--CNDLFRF----------------------------NNINLDPLTETYGIPFYLQYLAHWPEYFIVA------------ G_aculeatus_ENSGACP00000015667 ------KLSMNLFLSKLHADVALREVKGHRANMTTLRPFT--CDDLFKF----------------------------NNINLDPLTETYGIPFYLQYLAHWPEYFIVA------------ C_intestinalis_ENSCINP00000021531 --------------------------------MTLYRPFT--CEDMLKF----------------------------NRVNLDPLTETYAVGFYLQYLAKWPEYFMVA------------ A_gambiae_AGAP001878-PA --------------------------------MTTLRPFT--CNDMFRF----------------------------NKVNLDPLTETYCLSFYMQYLAHWPEYFQVA------------ A_aegypti_AAEL009373-PA --------------------------------MTTLRPFT--CNDMFKF----------------------------NKVNLDPLTETYCLAFYMQYLAHWPEYFQVA------------ E_caballus_ENSECAP00000010421 --------------------------------------------------------------------------------NLDPLTETYGIPFYLQYLAHWPEYFIVA------------ G_gorilla_ENSGGOP00000004164 --------------------------------------------------------------------------------NLDPLTETYGIPFYLQYLAHWPEYFIVA------------ T_rubripes_ENSTRUP00000039378 --------------------------------MTTLRPFT--CDDLFKF----------------------------NNINLDPLTETYGIPFYLQYLAHWPEYFIVA------------ M_musculus_ENSMUSP00000002805 --------------------------------MTTLRAFT--CDDLFRF----------------------------NNINLDPLTETYGIPFYLQYLAHWPEYFIVA------------ R_norvegicus_ENSRNOP00000014047 --------------------------------MTTLRAFT--CDDLFRF----------------------------NNINLDPLTETYGIPFYLQYLAHWPEYFIVA------------ T_guttata_ENSTGUP00000010800 --------------------------------MTTLRAFT--CDDLFRF----------------------------NNINLDPLTETYGIPFYLQYLAHWPEYFIVA------------ M_domestica_ENSMODP00000007334 --------------------------------MTTLRAFT--CDDLFRF----------------------------NNINLDPLTETYGIPFYLQYLAHWPEYFIVA------------ C_elegans_Y97E10AL.3 --------------------------------MTTLRPFD--VMDMFKF----------------------------NNVNLDINTETYGFQFYLHYMMNYPEYYQVA------------ M_mulatta_ENSMMUP00000010124 -----------------------------------------------LV----------------------------SFSNLDPLTETYGIPFYLQYLAHWPEYFIVA------------ S_cerevisiae_YPR131C --------------------------------MTTIQPFE--PVDLFKT----------------------------NNVNLDILTENFPLEFYFEYMIIWPDLFFKSSEMTVD------ D_melanogaster_FBpp0080059 --------------------------------MTSFREMR--FDDLFKI----------------------------NSLVFDALTEVYSLTFFVKHFLEFPGLSQIAIA---------- D_melanogaster_FBpp0080033 --------------------------------MTSPRLFV--LEDLFKF----------------------------NNIVMDPLAEVYSLPFLLPKILEHPELVLAA------------ S_cerevisiae_YPR051W -----------------------------------IVYKPLDIRNEEQF-------------------------ASIKKLIDADLSEPYSIYVYRYFLNQWPELTYIA------------ A_gambiae_AGAP003917-PA DKAE-GKSQRPTAAT-ALQ--DADRGQVQQPADADIRYQV--YESERQM-------------------------PAIMALIQKDLSEPYSIYTYRYFIHNWPKLCFLA------------ O_anatinus_ENSOANP00000018747 -------------------------------------------------------------------------------LITKDLSEPYSIYTYRYFIHNWPQLCFLA------------ A_aegypti_AAEL012413-PA KPEDPPKKEDTTVVL-PAN--ESPPAAPEEPPKPTITYQV--YESELQM-------------------------PCIMSLIQKDLSEPYSIYTYRYFIHNWPRLCFLA------------ M_domestica_ENSMODP00000009636 ESLL-VLSSSLTAAC-SLT--TSSDREAEPEEDRTIRYVR--YESELQM-------------------------PDIMRLITKDLSEPYSIYTYRYFIHNWPQLCFLA------------ A_carolinensis_ENSACAP00000000646 ---------------------SGQGEEGE-EEDPTIRYVR--YESELQM-------------------------PDIMRLITKDLSEPYSIYTYRYFIHNWPQLCFFA------------ G_gallus_ENSGALP00000019734 ESLL-LLSRSLAAGC-SL---KGSGTDSQPEEDLTIRYVR--YESELQM-------------------------PDIMRLITKDLSEPYSIYTYRYFIHNWPQLCFLA------------ C_familiaris_ENSCAFP00000022463 RQVR-LLSSSLTTGC-SLR--SPSGREVEPGEDRTIRYVR--YESELQM-------------------------PDIMRLITKDLSEPYSIYTYRYFIHNWPQLCFLA------------ E_caballus_ENSECAP00000010635 -----LLAASLAAGC-SLR--SPSGREVEPGEDRTIRYVR--YESELQM-------------------------PDIMRLITKDLSEPYSIYTYRYFIHNWPQLCFLA------------ R_norvegicus_ENSRNOP00000020074 EQVR-LLSSSLTTGC-SLS--SSLGREAEPGEDRTIRYVR--YESELQM-------------------------PDIMRLITKDLSEPYSIYTYRYFIHNWPQLCFLA------------ H_sapiens_ENSP00000298406 EQVR-LLSSSLTADC-SLR--SPSGREVEPGEDRTIRYVR--YESELQM-------------------------PDIMRLITKDLSEPYSIYTYRYFIHNWPQLCFLA------------ P_troglodytes_ENSPTRP00000010832 EQVR-LLSSSLTADC-SLR--SPSGREVEPGEDRTIRYVR--YESELQM-------------------------PDIMRLITKDLSEPYSIYTYRYFIHNWPQLCFLA------------ D_melanogaster_FBpp0072598 DKDSQEKMDLVTKNLPLFAEKIVLPENDTAAKSEGIHFCV--FHDESQL-------------------------KVLMGLIDKELSEPYSIYTYRYFVYNWPDLCFFA------------ M_mulatta_ENSMMUP00000028074 EQVR-LLSSSLTADC-SLR--SPSGREVEPGEDRTIRYVR--YESELQM-------------------------PDIMRLITKDLSEPYSIYTYRYFIHNWPQLCFLA------------ P_pygmaeus_ENSPPYP00000006647 EQVR-LLSSSLTADC-SLR--SPSGREVEPGEDRTIRYVR--YESELQM-------------------------PDIMRLITKDLSEPYSIYTYRYFIHNWPQLCFLA------------ T_guttata_ENSTGUP00000013437 ESLQ-LLSGSLAAAC-SL---KGSGTDCQPEEDLTIRYVQ--YESELQM-------------------------PDIMRLITKDLSEPYSIYTYRYFIHNWPQLCFLA------------ X_tropicalis_ENSXETP00000026216 ESL-----SACLAAC-TLRGGEAHSNHVS-QGDDTIRYVR--YESELQM-------------------------PDIMRLITRDLSEPYSIYTYRYFIHNWPQLCFLA------------ B_taurus_ENSBTAP00000017282 EQVR-LLASSLTAGC-SLR--SPSGREVEPGEDRTIRYVR--YESELQM-------------------------PDIMRLITKDLSEPYSIYTYRYFIHNWPQLCFLA------------ M_musculus_ENSMUSP00000041450 EQVR-LLSSSLTTGC-SLR--SSQGREAEPGEDRTIRYVR--YESELQM-------------------------PDIMRLITKDLSEPYSIYTYRYFIHNWPQLCFLV------------ D_melanogaster_FBpp0070203 DYAE-GATPTITAQL------QLPEPAI---SADEIVYKE--YEAEHQMHVSTSKYDQVRTVRNTYLIPRISNTQDIMRLIQAELSEPYSIYTYRYFIYNWPKLCFLA------------ C_intestinalis_ENSCINP00000010530 YALS-CLTISNTKGLYPINATNDDHSENIVCASNGICYAR--YSSELQM-------------------------PAIMHLITKDLSEPYSIYTYRYFIHNWPHLCYLA------------ G_aculeatus_ENSGACP00000016825 ELAR-LD--------------LGGSPGRAEEDGHGIRYVR--YESELQM-------------------------PWIMRLITKDLSEPYSIYTYRYFIHNWPQLCFLA------------ T_nigroviridis_ENSTNIP00000004980 -----------------------------PGDSHGICYVR--YESELQM-------------------------PWIMRLITKDLSEPYSIYTYRYFIHNWPQLCFLA------------ O_latipes_ENSORLP00000018946 ELAR-LD--------------LSGSPG---PDSHGIRYVR--YESELQM-------------------------PWIMRLITKDLSEPYSIYTYRYFIHNWPQLCFLA------------ C_elegans_B0238.10 ESVP-EASKWPHCQH-MIS--QDEAPRNDELASPNIRIVA--YKDESQI-------------------------NDIMRLITKDLSEPYSIYTYRYFLHNWPEYCFLA------------ T_rubripes_ENSTRUP00000029061 EMAR-LD--------------LGTSSSQTEADSHGICYVR--YESELQM-------------------------PWIMRLITKDLSEPYSIYTYRYFIHNWPQLCFLA------------ O_cuniculus_ENSOCUP00000013296 --------------------------------MTMLRALT--CDDLFLF----------------------------NNXXXXXXXXXXXXXXXXXXXXXXXXXXXXX------------ B_taurus_ENSBTAP00000010234 ----------------------------MKGSRIELGDVT--PHNIKQL----------------------------KRLNQVIFPVSYNDKFYK-DVLEVGELAKLA------------ O_anatinus_ENSOANP00000018738 --------------------RPGAMGNTGWSSRIELGDVT--PHNIKQL----------------------------KRLNQVIFPVSYNDKFYK-DVLEVGELAKLA------------ M_domestica_ENSMODP00000022643 ------------------ICGGIEHILVCSSSRIELGDVT--PHNIKQL----------------------------KRLNQVIFPVSYNDKFYK-DVLEVGELAKLA------------ A_carolinensis_ENSACAP00000006601 -----------------------------FSSRIELGDVT--PHNIKQL----------------------------KRLNQVIFPVSYNDKFYK-DVLEVGELAKLA------------ P_troglodytes_ENSPTRP00000051155 -------------------------------SRIELGDVT--PHNIKQL----------------------------KRLNQVIFPVSYNDKFYK-DVLEVGELAKLA------------ E_caballus_ENSECAP00000020661 -----------------------------SSSRIELGDVT--PHNIKQL----------------------------KRLNQVIFPVSYNDKFYK-DVLEVGELAKLA------------ M_mulatta_ENSMMUP00000039993 -----------------------------SSSRIELGDVT--PHNIKQL----------------------------KRLNQVIFPVSYNDKFYK-DVLEVGELAKLA------------ G_gallus_ENSGALP00000023856 ----------------------------MKGSRIELGDVT--PHNIKQL----------------------------KRLNQVIFPVSYNDKFYK-DVLEVGELAKLA------------ X_tropicalis_ENSXETP00000021826 -----------------------------SSSRIELGDVT--PHNIKQL----------------------------KRLNQVIFPVSYNDKFYK-DVLEVGELAKLA------------ H_sapiens_ENSP00000240922 ----------------------------MKGSRIELGDVT--PHNIKQL----------------------------KRLNQVIFPVSYNDKFYK-DVLEVGELAKLA------------ P_pygmaeus_ENSPPYP00000015136 ----------------------------MKGSRIELGDVT--PHNIKQL----------------------------KRLNQVIFPVSYNDKFYK-DVLEVGELAKLA------------ T_guttata_ENSTGUP00000013754 -----------------------------SSSRIELGDVT--PHNIKQL----------------------------KRLNQVIFPVSYNDKFYK-DVLEVGELAKLA------------ D_melanogaster_FBpp0087227 ----------------------------MTRSSIELGDVT--PHNIKQL----------------------------KKLNTVVFPVSYNDKFYV-DVLEAGELAKLA------------ O_latipes_ENSORLP00000011435 ----------------------MPKNRGNNDSRIELGDVT--PHNIKQL----------------------------KRLNQVIFPVSYNDKFYK-DVLEVGELAKLA------------ C_familiaris_ENSCAFP00000015737 ----------------------KAGFISHEDSRIELGDVT--PHNIKQL----------------------------KRLNQVIFPVSYNDKFYK-DVLEVGELAKLA------------ D_rerio_ENSDARP00000032139 -----------------------------MKGRIELGDVT--PHNIKQL----------------------------KRLNQVIFPVSYNDKFYK-DVLEVGELAKLA------------ 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0076078 VDDK--------------------------GA-----IVGY--------------VLAKM---------EEPEPNE---ESRHGHITSLAVKRSYRRLGLAQKLMNQASQAMVE--CFNA A_gambiae_AGAP005410-PC EDDK--------------------------GN-----IVGY--------------VLAKM---------EEPEPGE---ESTHGHITSLAVKRSYRRLGLAQKLMNQASKAMVE--CFNA A_aegypti_AAEL006743-PA EDDK--------------------------GN-----IVGY--------------VLAKM---------EEPEPGE---ESTHGHITSLAVKRSYRRLGLAQKLMNQASHAMVE--CFNA X_tropicalis_ENSXETP00000046985 EDEN--------------------------GK-----IVGY--------------VLAKM---------EEDP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFNA D_rerio_ENSDARP00000095595 EDEN--------------------------GK-----IVGY--------------VLAKM---------EEDP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFNA D_rerio_ENSDARP00000095601 EDEN--------------------------GK-----IVGY--------------VLAKM---------EEDP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFNA P_troglodytes_ENSPTRP00000027844 EDED--------------------------GK-----IVGY--------------VLAKM---------EEEP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFNA T_nigroviridis_ENSTNIP00000018147 EDEN--------------------------GK-----IVGY--------------VLAKM---------EEDP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFNA H_sapiens_ENSP00000286794 EDED--------------------------GK-----IVGY--------------VLAKM---------EEEP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFNA G_gorilla_ENSGGOP00000012626 EDED--------------------------GK-----XVGY--------------VLAKM---------EEEP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFNA C_familiaris_ENSCAFP00000028702 EDEN--------------------------GK-----IVGY--------------VLAKM---------EEDP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFNA G_aculeatus_ENSGACP00000011405 EDEN--------------------------GK-----IVGY--------------VLAKM---------EEDP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFSA M_musculus_ENSMUSP00000057336 EDED--------------------------GK-----IVGY--------------VLAKM---------EEDP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFGA M_musculus_ENSMUSP00000025463 EDED--------------------------GK-----IVGY--------------VLAKM---------EEDP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFSA O_latipes_ENSORLP00000008862 EDEN--------------------------GK-----IVGY--------------VLAKM---------EEDP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFNA H_sapiens_ENSP00000359032 EDEN--------------------------GK-----IVGY--------------VLAKM---------EEDP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFNA M_mulatta_ENSMMUP00000040755 EDEN--------------------------GK-----IVGY--------------VLAKM---------EEDP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFNA P_pygmaeus_ENSPPYP00000023349 EDEN--------------------------GK-----IVGY--------------VLAKM---------EEDP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFNA E_caballus_ENSECAP00000013004 EDEN--------------------------GK-----IVGY--------------VLAKM---------EEDP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFNA G_gorilla_ENSGGOP00000009559 EDEN--------------------------GK-----IVGY--------------VLAKM---------EEDP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFNA R_norvegicus_ENSRNOP00000044568 EDEN--------------------------GK-----IVGY--------------VLAKM---------EEDP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFNA T_rubripes_ENSTRUP00000039218 EDEN--------------------------GK-----IVGY--------------VLAKM---------EEDP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFNA M_musculus_ENSMUSP00000033763 EDEN--------------------------GK-----IVGY--------------VLAKM---------EEDP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFNA B_taurus_ENSBTAP00000017477 EDED--------------------------GK-----IVGY--------------VLAKM---------EEDP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFSA M_mulatta_ENSMMUP00000035248 EDED--------------------------GK-----IVGY--------------VLAKM---------EEDP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFNA O_cuniculus_ENSOCUP00000008706 EDED--------------------------GK-----IVGY--------------VLAKM---------EEDP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--SFSA R_norvegicus_ENSRNOP00000002776 EDED--------------------------GK-----IVGY--------------VLAKM---------EEDP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFSA M_domestica_ENSMODP00000014446 EDEN--------------------------GK-----IVGY--------------VLAKM---------EEDP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFNA A_carolinensis_ENSACAP00000012021 EDEN--------------------------GK-----IVGY--------------VLAKM---------EEDP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFNA C_elegans_K07H8.3 EDHK--------------------------GN-----VVGY--------------VLAKM---------EEDP--G---EEPHGHITSLAVKRSYRRLGLANKMMDQTARAMVE--TYNA C_intestinalis_ENSCINP00000013819 EDAK--------------------------GN-----IVGY--------------VLAKM---------EEDP--D---EATHGHITSLAVKRSHRRLGLARKLMDHASRAMVE--SFKA O_cuniculus_ENSOCUP00000000964 XXXX--------------------------XX-----XXXX--------------XXXXX---------EEDP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFNA R_norvegicus_ENSRNOP00000056134 EDEV--------------------------GK-----IMGY--------------VLAKM---------EEDP--D---NVPHEHITSLALMRSHRRFSLAKKLMDQTTQAMME--DFSA O_anatinus_ENSOANP00000004594 EDEN--------------------------GK-----IVGY--------------VLAKM---------EEDP--D---DVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIE--NFNA R_norvegicus_ENSRNOP00000049533 EDEV--------------------------GK-----IVGY--------------VLAKM---------EEDP--D---NVPYEHITSLAVKRSH-TFDLAKKLMDQASQAMIK--NIDT S_cerevisiae_YHR013C QDENDKLELTLDGTNDGRTIKLDPTYLAPGEK-----LVGY--------------VLVKM---------NDDP--DQQNEPPNGHITSLSVMRTYRRMGIAENLMRQALFALRE--VHQA T_guttata_ENSTGUP00000015789 EDEN--------------------------GK-----IVGY--------------VLAKM---------EEDP--Y---DVPHGHITSL------------------------------- P_troglodytes_ENSPTRP00000038636 EDEN--------------------------GK-----IVGY--------------VLAK------------------------------------------------------------- D_melanogaster_FBpp0074532 ESPS--------------------------GQ-----IMGY--------------IMGKV---------EGHL------DNWHGHVTALTVSPDYRRLGLAALLMS-FLEDISE--KKRA D_rerio_ENSDARP00000057699 EAPG--------------------------GE-----LMGY--------------IMGKA---------EGSV----AREEWHGHVTALSVAPEFRRLGLAAKLME-MLEEISE--RKGG T_nigroviridis_ENSTNIP00000013627 EAPG--------------------------GE-----LMGY--------------IMGKA---------EGSV----AREEWHGHVTALSVAPEFRRLGLAAKLME-MLEEISE--RKGG C_familiaris_ENSCAFP00000007989 EAPG--------------------------GE-----LMGY--------------IMGKA---------EGSV----AREEWHGHVTALSVAPEFRRLGLAAKLME-LLEEISER-RKGG B_taurus_ENSBTAP00000001522 EAPG--------------------------GE-----LMGY--------------IMGKA---------EGSV----AREEWHGHVTALSVAPEFRRLGLAAKLME-LLEEISE--RKGG H_sapiens_ENSP00000335636 EAPG--------------------------GE-----LMGY--------------IMGKA---------EGSV----AREEWHGHVTALSVAPEFRRLGLAAKLME-LLEEISE--RKGG G_gallus_ENSGALP00000020525 EAPG--------------------------GE-----LMGY--------------IMGKA---------EGSV----AREEWHGHVTALSVAPEFRRLGLAAKLME-LLEEISE--KKGG P_pygmaeus_ENSPPYP00000012011 EAPG--------------------------GE-----LMGY--------------IMGKA---------EGSV----AREEWHGHVTALSVAPEFRRLGLAAKLME-LLEEISE--RKGG P_troglodytes_ENSPTRP00000022806 EAPG--------------------------GE-----LMGY--------------IMGKA---------EGSV----AREEWHGHVTALSVAPEFRRLGLAAKLME-LLEEISE--RKGG O_latipes_ENSORLP00000021581 EAPG--------------------------GE-----LMGY--------------IMGKA---------EGSV----AREEWHGHVTALSVAPEFRRLGLAAKLME-MLEEISE--RKGG A_carolinensis_ENSACAP00000005151 EAPG--------------------------GE-----LMGY--------------IMGKA---------EGSV----AREEWHGHVTALSVAPEFRRLGLAAKLME-LLEEISE--KKGG G_aculeatus_ENSGACP00000015667 EAPG--------------------------GE-----LMGY--------------IMGKA---------EGSV----AREEWHGHVTALSVAPEFRRLGLAAKLME-MLEEISE--RKGG C_intestinalis_ENSCINP00000021531 ESPG--------------------------GD-----IMGY--------------IMGKV---------EGRT----S-DDWHGHVTALSVSSEYRRIRLAAELMQ-HLEDVSE--KKKA A_gambiae_AGAP001878-PA ESPT--------------------------GE-----IMGY--------------IMGKA---------EGQG------ESWHGHVTALTVSPDYRRLGLAATLMS-FLEDVSE--KKRC A_aegypti_AAEL009373-PA ESPS--------------------------GE-----IMGY--------------IMGKA---------AGHG------ENWHGHVTALTVSPDYRRLGLAATLMN-FLEDVSE--KKRC E_caballus_ENSECAP00000010421 EAPG--------------------------GE-----LMGY--------------IMGKA---------EGSV----AREEWHGHVTALSVAPEFRRLGLAAKLME-LLEEISE--RKGG G_gorilla_ENSGGOP00000004164 EAPG--------------------------GE-----LMGY--------------IMGKA---------EGSV----AREEWHGHVTALSVAPEFRRLGLAAKLME-LLEEISE--RKGG T_rubripes_ENSTRUP00000039378 EAPG--------------------------GE-----LMGYSKF-----CSNTFPVMGKA---------EGSV----AREEWHGHVTALSVAPEFRRLGLAAKLME-MLEEISE--RKGG M_musculus_ENSMUSP00000002805 EAPG--------------------------GE-----LMGYSKYS----TTSTFLVMGKA---------EGSV----AREEWHGHVTALSVAPEFRRLGLAAKLME-LLEEISE--RKGG R_norvegicus_ENSRNOP00000014047 EAPG--------------------------GE-----LMGYSKYS----TTSTFLVMGKA---------EGSV----AREEWHGHVTALSVAPEFRRLGLAAKLME-LLEEISE--RKGG T_guttata_ENSTGUP00000010800 EAPG--------------------------GE-----LMGYSA---AVLMLSVFTVMGKA---------EGSV----AREEWHGHVTALSVAPEFRRLGLAAKLME-LLEEISE--KKGG M_domestica_ENSMODP00000007334 EAPG--------------------------GE-----LMGYSKYTLYILLIYFLLVMGKA---------EGSV----AREEWHGHVTALSVAPEFRRLGLAAKLME-LLEEISE--RKGG C_elegans_Y97E10AL.3 EHPN--------------------------GE-----IMAY--------------VMGKI---------EGRD------TNWHGHVTALSVAPNFRRLGLAAYMME-FLERTSE--ARRA M_mulatta_ENSMMUP00000010124 EAPG--------------------------GE-----LMGY--------------IMGKA---------EGSV----AREEWHGHVTALSVAPEFRRLGLAAKLME-LLEEISE--RKGG S_cerevisiae_YPR131C PTFK--------------------------HN-----ISGY--------------MMAKT---------EGKT------TEWHTHITAVTVAPRFRRISLASKLCN-TLETMTDVMPHEV D_melanogaster_FBpp0080059 PGPD--------------------------GR-----PMGY--------------IFGQY---------QVKR--N---QDPYGHVAALTVSPEYRRLGLATALMD-FFFMVSD--LKGA D_melanogaster_FBpp0080033 DAPD--------------------------NS-----LMGF--------------ILGTRVEDATESFGDAKT-----MTWNHGHISALAVAQDYRKLGLGTRLLT-TVRDMMD--RQKD S_cerevisiae_YPR051W VDNK---------------------------SGTPNIPIGC--------------IVCKM---------DPHR--N---VRLRGYIGMLAVESTYRGHGIAKKLVEIAIDKMQR---EHC A_gambiae_AGAP003917-PA LHRD---------------------------T-----CVGA--------------IVCKL---------DIHR--Q---ETRRGYIAMLAVDKDYRKLKIGTTLVQKAIQAMVE---DHA O_anatinus_ENSOANP00000018747 VVGE---------------------------E-----CVGA--------------IVCKL---------DMHK--K---MFRRGYIAMLAVDSKYRRKGIGTNLVKKAIYAMVE---GDC A_aegypti_AAEL012413-PA WHEE---------------------------R-----CVGA--------------IVCKL---------DIHR--Q---NVRRGYIAMLAVDKDYRKLKIGTTLVQKAIQAMLE---DNA M_domestica_ENSMODP00000009636 VVGE---------------------------E-----CVGA--------------IVCKL---------DMHK--K---MFRRGYIAMLAVDSKYRRNGIGTNLVKKAIYAMVE---GDC A_carolinensis_ENSACAP00000000646 MVGD---------------------------E-----CVGA--------------IVCKL---------DMHK--K---MFRRGYIAMLAVDSKYRRKGIGTNLVKKAIYAMVE---GDC G_gallus_ENSGALP00000019734 MVGE---------------------------E-----CVGA--------------IVCKL---------DMHK--K---MFRRGYIAMLAVDSKYRRKGIGTNLVKKAIYAMVE---GDC C_familiaris_ENSCAFP00000022463 MVGE---------------------------E-----CVGA--------------IVCKL---------DMHK--K---MFRRGYIAMLAVDSKYRRNGIGTNLVKKAIYAMVE---GDC E_caballus_ENSECAP00000010635 MVGE---------------------------E-----CVGA--------------IVCKL---------DMHK--K---MFRRGYIAMLAVDSKYRRNGIGTNLVKKAIYAMVE---GDC R_norvegicus_ENSRNOP00000020074 MVGE---------------------------E-----CVGA--------------IVCKL---------DMHK--K---MFRRGYIAMLAVDSKYRRNGIGTNLVKKAIYAMVE---GDC H_sapiens_ENSP00000298406 MVGE---------------------------E-----CVGA--------------IVCKL---------DMHK--K---MFRRGYIAMLAVDSKYRRNGIGTNLVKKAIYAMVE---GDC P_troglodytes_ENSPTRP00000010832 MVGE---------------------------E-----CVGA--------------IVCKL---------DMHK--K---MFRRGYIAMLAVDSKYRRNGIGTNLVKKAIYAMVE---GDC D_melanogaster_FBpp0072598 LDGD---------------------------R-----YVGV--------------IVCKL---------EAKR--D---GYLQGYIAMLAVDAEYRKRGIGRALSEMAIDAMAI---RDA M_mulatta_ENSMMUP00000028074 MVGE---------------------------E-----CVGA--------------IVCKL---------DMHK--K---MFRRGYIAMLAVDSKYRRNGIGTNLVKKAIYAMVE---GDC P_pygmaeus_ENSPPYP00000006647 MVGE---------------------------E-----CVGA--------------IVCKL---------DMHK--K---MFRRGYIAMLAVDSKYRRNGIGTNLVKKAIYAMVE---GDC T_guttata_ENSTGUP00000013437 MVGE---------------------------E-----CVGA--------------IVCKL---------DMHK--K---MFRRGYIAMLAVDSKYRRKGIGTNLVKKAIYAMVE---GDC X_tropicalis_ENSXETP00000026216 MVGE---------------------------E-----CVGA--------------IVCKL---------DMHK--K---MFRRGYIAMLAVDSKYRRKGIGTNLVKKAIYAMVE---GDC B_taurus_ENSBTAP00000017282 MVGE---------------------------E-----CVGA--------------IVCKL---------DMHK--K---MFRRGYIAMLAVDSKYRRNGIGTNLVKKAIYAMVE---GDC M_musculus_ENSMUSP00000041450 SGWN---------------------------E---NRCVGA--------------IVCKL---------DMHK--K---MFRRGYIAMLAVDSKYRRNGIGTNLVKKAIYAMVE---GDC D_melanogaster_FBpp0070203 SHDN---------------------------Q-----YVGA--------------IVCKL---------DMHM--N---V-RRGYIAMLAVRKEYRKLKIGTTLVTKAIEAMLA---DNA C_intestinalis_ENSCINP00000010530 IHEA---------------------------N-----YVGA--------------IVCKL---------DLHK--K---ITRRGYIAMLAVDESVRRKKIGTNLVKMAIEAMVE---DGC G_aculeatus_ENSGACP00000016825 MVEQ---------------------------E-----CVGA--------------IVCKL---------DMHK--K---MFRRGYIAMLAVDSKHRRKSIGTNLVKKAIYAMVE---GDC T_nigroviridis_ENSTNIP00000004980 MVGQ---------------------------E-----CVGA--------------IVCKL---------DMHK--K---MFRRGYIAMLAVDSKHRRKSIGTNLVKKAIYAMVE---GDC O_latipes_ENSORLP00000018946 MVEQ---------------------------E-----CVGA--------------IVCKL---------DMHK--K---MFRRGYIAMLAVDSKHRRKSIGTNLVKKAIYAMVE---GDC C_elegans_B0238.10 YDQT---------------------------N---NTYIGA--------------VLCKL---------ELDM--Y---GRCKGYLAMLAVDESCRRLGIGTRLVRRALDAMQS---KGC T_rubripes_ENSTRUP00000029061 MVGQ---------------------------E-----CVGA--------------IVCKL---------DMHK--K---MFRRGYIAMLAVDSKHRRKSIGTNLVKKAIYAMVE---GDC O_cuniculus_ENSOCUP00000013296 XXXX--------------------------XX-----XXXX--------------XMGKA---------EGSV----AREEWHGHVTALSVAPEFRRLGLAAKLME-LLEEISE--RKGG B_taurus_ENSBTAP00000010234 YFND---------------------------I-----AVGA--------------VCCRV---------DHSQ------NQKRLYIMTLGCLAPYRRLGIGTKMLNHVLNICEK--DGNF O_anatinus_ENSOANP00000018738 YFND---------------------------I-----AVGA--------------VCCRV---------DHSQ------SQKRLYIMTLGCLAPYRRLGIGTKMLNHVLNICEK--DGTF M_domestica_ENSMODP00000022643 YFND---------------------------I-----AVGA--------------VCCRV---------DHSQ------NQKRLYIMTLGCLAPYRRLGIGTKMLNHVLNICEK--DGTF A_carolinensis_ENSACAP00000006601 YFND---------------------------I-----AVGA--------------VCCRV---------DHSQ------NQKRLYIMTLGCLAPYRRLGIGTKMLNHVLNICEK--DGTF P_troglodytes_ENSPTRP00000051155 YFND---------------------------I-----AVGA--------------VCCRV---------DHSQ------NQKRLYIMTLGCLAPYRRLGIGTKMLNHVLNICEK--DGTF E_caballus_ENSECAP00000020661 YFND---------------------------I-----AVGA--------------VCCRV---------DHSQ------NQKRLYIMTLGCLAPYRRLGIGTKMLNHVLNICEK--DGTF M_mulatta_ENSMMUP00000039993 YFND---------------------------I-----AVGA--------------VCCRV---------DHSQ------NQKRLYIMTLGCLAPYRRLGIGTKMLNHVLNICEK--DGTF G_gallus_ENSGALP00000023856 YFND---------------------------I-----AVGA--------------VCCRV---------DHSQ------NQKRLYIMTLGCLAPYRRLGIGTKMLNHVLNICEK--DGTF X_tropicalis_ENSXETP00000021826 YFND---------------------------I-----AVGA--------------VCCRV---------DHSQ------NQKRLYIMTLGCLAPYRRLGIGTKMLNHVLNICEK--DGTF H_sapiens_ENSP00000240922 YFND---------------------------I-----AVGA--------------VCCRV---------DHSQ------NQKRLYIMTLGCLAPYRRLGIGTKMLNHVLNICEK--DGTF P_pygmaeus_ENSPPYP00000015136 YFND---------------------------I-----AVGA--------------VCCRV---------DHSQ------NQKRLYIMTLGCLAPYRRLGIGTKMLNHVLNICEK--DGTF T_guttata_ENSTGUP00000013754 YFND---------------------------I-----AVGA--------------VCCRV---------DHSQ------NQKRLYIMTLGCLAPYRRLGIGTKMLNHVLNICEK--DGTF D_melanogaster_FBpp0087227 YYND---------------------------I-----VVGA--------------VCCRI---------DNTE------NQRRLYIMTLGCLSPYRRLGIGTVMFEHIMNFAEK--DGNF O_latipes_ENSORLP00000011435 YFND---------------------------I-----AVGA--------------VCCRV---------DHSQ------NQKRLYIMTLGCLAPYRRLGIGTKMLNHVLNICEK--DGTF C_familiaris_ENSCAFP00000015737 YFND---------------------------I-----AVGA--------------VCCRV---------DHSQ------NQKRLYIMTLGCLAPYRRLGIGTKMLNHVLNICEK--DGTF D_rerio_ENSDARP00000032139 YFND---------------------------I-----AVGA--------------VCCRV---------DHSQ------NQKRLYIMTLGCLAPYRRLGIGTKMLNHVLNICEK--DGTF 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0076078 QYVSLHVRKSNRAAL-NLYTNALKFKIIEVEPKYYAD--------------GEDAYAMRRDLS----EFADED------------QAK--AAKQS-----GEEEEK-------------- A_gambiae_AGAP005410-PC QYVSLHVRKSNRAAL-NLYTNSLGFKILEIEPKYYAD--------------GEDAYSMRRDLS----ELVNNS------------DRP--PAERNELNDVGGDDRI-------------- A_aegypti_AAEL006743-PA QYVSLHVRKSNRAAL-NLYTNSLGFRILEIEPKYYAD--------------GEDAYSMRRDLA----ELAELY-------------------------GAGREHSD-------------- X_tropicalis_ENSXETP00000046985 KYVSLHVRKSNRAAL-HLYSNTLNFQISEVEPKYYAD--------------GEDAYAMKRDLT----QMADEL------------RKQLEIKEKSR--PLSSIENKSDNRSG---HVGDC D_rerio_ENSDARP00000095595 KYVSLHVRKSNRAAL-HLYSNTLKFQISEVEPKYYAD--------------GEDAYAMKRNLT----QMADEL------------QKPGVRL-WGSEAPPSQDTSV--TGLVEKLTVQDG D_rerio_ENSDARP00000095601 KYVSLHVRKSNRAAL-HLYSNTLKFQISEVEPKYYAD--------------GEDAYAMKRNLT----QMADEL------------QKPGVRL-WGSEAPPSQDTSV--TGLVEKLTVQDG P_troglodytes_ENSPTRP00000027844 KYVSLHVRKSNRAAL-HLYSNTLNFQISEVEPKYYAD--------------GEDAYAMKRDLS----QMADEL------------RRQTDLK-KGGYVVLGSRENQ-ETQGSTLSDSEEA T_nigroviridis_ENSTNIP00000018147 KYVSLHVRKSNRAAL-HLYSNTLKFQISEVEPKYYAD--------------GEDAYAMKRDLA----HMADEL------------RKPGTRA-SGQEVPSGQSPSG----------SGDH H_sapiens_ENSP00000286794 KYVSLHVRKSNRPAL-HLYSNTLNFQISEVEPKYYAD--------------GEDAYAMKRDLS----QMADEL------------RRQMDLK-KGGYVVLGSRENQ-ETQGSTLSDSEEA G_gorilla_ENSGGOP00000012626 KYVSLHVRKSNRAAL-HLYSNTLNFQISEVEPKYYAD--------------GEDAYAMKRDLS----QMADEL------------RRQVDLK-KGGYVVLGSRENQ-ETQGSTLSDSEEA C_familiaris_ENSCAFP00000028702 KYVSLHVRKSNRAAL-HLYSNTLNFQISEVEPKYYAD--------------GEDAYAMKRDLT----QMADEL------------RRHLELKDKGRHVVLGAIENKVEGRGSSLPSSGDA G_aculeatus_ENSGACP00000011405 KYVSLHVRKSNRAAL-HLYSNTLKFQISEIEPKYYAD--------------GEDAYAMKRDLA----HMADEV------------KKPGVRL-SGQEAASGQNPSG----------SGDQ M_musculus_ENSMUSP00000057336 KYVSLHVRKSNRAAL-HLYSNTLNFQVSEVEPKYYAD--------------GEDAYAMKRDLS----QMTDEL------------RRQLVLK-KNRYVVLGSEETQ----GGTLPDAGEA M_musculus_ENSMUSP00000025463 KYVSLHVRKSNRAAL-HLYSNTLNFQVSEVEPKYYAD--------------GEDAYAMKRDLS----QMADEL------------RRQLVLK-KGRYVVLGSKENQ----GSTLPGSEEA O_latipes_ENSORLP00000008862 KYVSLHVRKSNRAAL-HLYSNTLKFQISEVEPKYYAD--------------GEDAYAMKRDLA----HMADEL------------RKPGIRV-SGQDAPSGH----------------DQ H_sapiens_ENSP00000359032 KYVSLHVRKSNRAAL-HLYSNTLNFQISEVEPKYYAD--------------GEDAYAMKRDLT----QMADEL------------RRHLELKEKGRHVVLGAIENKVESKGNSPPSSGEA M_mulatta_ENSMMUP00000040755 KYVSLHVRKSNRAAL-HLYSNTLNFQISEVEPKYYAD--------------GEDAYAMKRDLT----QMADEL------------RRHLELKEKGRHVVLGAIENKVESKGNSPPSSGEA P_pygmaeus_ENSPPYP00000023349 KYVSLHVRKSNRAAL-HLYSNTLNFQISEVEPKYYAD--------------GEDAYAMKRDLT----QMADEL------------RRHLELKEKGRHVVLGAIENKVESKGNSPPSSGEA E_caballus_ENSECAP00000013004 KYVSLHVRKSNRAAL-HLYSNTLNFQISEVEPKYYAD--------------GEDAYAMKRDLT----QMADEL------------RRHLELKEKGRHMVLGSIENKVESKGNSLPSSGEA G_gorilla_ENSGGOP00000009559 KYVSLHVRKSNRAAL-HLYSNTLNFQISEVEPKYYAD--------------GEDAYAMKRDLT----QMADE------------------------------------------------ R_norvegicus_ENSRNOP00000044568 KYVSLHVRKSNRAAL-HLYSNTLNFQISEVEPKYYAD--------------GEDAYAMKRDLT----QMADEL------------RRHLELKEKGRHMVLSAMENKAENKGNVLLSSGEA T_rubripes_ENSTRUP00000039218 KYVSLHVRKSNRAAL-HLYSNTLKFQISEVEPKYYAD--------------GEDAYAMKRDLA----HMADEVTLFFNFQASHNLRKPGTRA-SGQEVSSGQSPSG----------SGDQ M_musculus_ENSMUSP00000033763 KYVSLHVRKSNRAAL-HLYSNTLNFQISEVEPKYYAD--------------GEDAYAMKRDLT----QMADEL------------RRHLELKEKGKHMVLAALENKAENKGNVLLSSGEA B_taurus_ENSBTAP00000017477 KYVSLHVRKSNRAAL-HLYSNTLNFQISEVEPRYYAD--------------GEDAYAMKRDLS----QMADEL------------RRQLQLK-KGGYVVLGSRENQ-ETQGSTLPGSKMA M_mulatta_ENSMMUP00000035248 KYVSLHVRKSNRAAL-HLYSNTLNFQISEVEPKYYAD--------------GEDAYAMKRDLS----QMADEL------------RRQVDLK-KGGYVVLGSRENQ-ETQGSTLCGSEEA O_cuniculus_ENSOCUP00000008706 KYVSLHVRKSNRAAL-HLYSDTLNFQVSEVEPKYYAD--------------VEDAYAMKRDLS----QMADVL------------RQQPEPKEKGGCVLLCSTESQ-ESQDSVLPGSADA R_norvegicus_ENSRNOP00000002776 KYVSLHVRKSNRAAL-HLYSNTLNFQVSEVEPKYYAD--------------GEDAYAMKRDLA----QMADEL------------RRQLVLK-KSRYVVLGSEENQ-EAQDSTLPDAEEA M_domestica_ENSMODP00000014446 KYVSLHVRKSNRAAL-HLYSNTLNFQISEVEPKYYAD--------------GEDAYAMKRD-T----QMAEEL------------RKQLEVKEKGKHLVLASLENKMDPRGN---HVGDC A_carolinensis_ENSACAP00000012021 KYVSLHVRKSNRAAL-HLYSNTLNFQISEVEPKYYAD--------------GEDAYAMKRDLT----QMAEEL------------RRQVELKEKSKHSVLGSIENK--GSDHKANHVGEC C_elegans_K07H8.3 KYVSLHVRVSNRAAL-NLYKNTLKFEIVDTEPKYYAD--------------GEDAYAMRRDLA----KWAEER--------------NIEPADREAYTTAKTTDDK-------------- C_intestinalis_ENSCINP00000013819 KYVSLHVRVSNRAAL-RLYAHTLKFEQSEVEAKYYAD--------------GEDAYAMKRDLT----KLLDEF------------SEP-------KKLFLPFREKQ----PAQVTPQVAV O_cuniculus_ENSOCUP00000000964 KYVSLHVRKSNRAAL-HLYSNTLNFQISEVEPKYYAD--------------GEDAYAMKRDLT----HMAEEL------------RRHLELKDKGRHVVLGAIENKVENKGGSLPSSGEA R_norvegicus_ENSRNOP00000056134 KYVSLHARKSNRAAL-HLYS-TLNFQVSEVEPKYYAD--------------GEDAYARKRDLS----QMADEL------------RSQLVLK-KSNYVVLGSKENQ----GSTHPGSEEA O_anatinus_ENSOANP00000004594 KYVSLHVRKSNRAALPSLLQHSSTFQ---------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000049533 N-VSLHARKSNRAAL-HLYS-TPNFQVSEVEPKSYAD--------------GEDAYARKRDLS----QIADEL------------RRQLVLK-KGRYVVLGSKENQ----GSTHPGSKEA S_cerevisiae_YHR013C EYVSLHVRQSNRAAL-HLYRDTLAFEVLSIEKSYYQD--------------GEDAYAMKKVLKLEELQISNFT------------HRR-----------LKENEEK-------------- T_guttata_ENSTGUP00000015789 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000038636 ------------------------------------------------------------DFT----QMAQEL------------RRHLELKEKGRHVVLGAIENKVESKGNSPPSSGEA D_melanogaster_FBpp0074532 YFVDLFVRKSNQVAI-NMYT-NLGYIIYRTILEYYSG------------DQDEDAYDMRKALS----RDVNKK----------------------------------------------- D_rerio_ENSDARP00000057699 FFVDLFVRVSNQVAV-NMYK-QLGYSVYRTVIEYYSASNG---------EPDEDAYDMRKALS----RDTEKK----------------------------------------------- T_nigroviridis_ENSTNIP00000013627 FFVDLFVRVSNQVAV-NMYK-RLGYSVYRTVIEYYSASNG---------EPDEDAYDMRKALS----RDTEKK----------------------------------------------- C_familiaris_ENSCAFP00000007989 FFVDLFVRVSNQVAV-NMYK-RLGYSVYRTVIEYYSASNG---------EPDEDAYDMRKALS----RDTEKK----------------------------------------------- B_taurus_ENSBTAP00000001522 FFVDLFVRVSNQVAV-NMYK-QLGYSVYRTVIEYYSASNG---------EPDEDAYDMRKALS----RDTEKK----------------------------------------------- H_sapiens_ENSP00000335636 FFVDLFVRVSNQVAV-NMYK-QLGYSVYRTVIEYYSASNG---------EPDEDAYDMRKALS----RDTEKK----------------------------------------------- G_gallus_ENSGALP00000020525 FFVDLFVRVSNQVAV-NMYK-QLGYSVYRTVLEYYSASNG---------EPDEDAYDMRKALS----RDTEKK----------------------------------------------- P_pygmaeus_ENSPPYP00000012011 FFVDLFVRVSNQVAV-NMYK-QLGYSVYRTVIEYYSASNG---------EPDEDAYDMRKALS----RDTEKK----------------------------------------------- P_troglodytes_ENSPTRP00000022806 FFVDLFVRVSNQVAV-NMYK-QLGYSVYRTVIEYYSASNG---------EPDEDAYDMRKALS----RDTEKK----------------------------------------------- O_latipes_ENSORLP00000021581 FFVDLFVRVSNQVAV-NMYR-RLGYSVYRTVIEYYSASNG---------EPDEDAYDMRKALS----RDTEKK----------------------------------------------- A_carolinensis_ENSACAP00000005151 FFVDLFVRVSNQVAV-NMYK-QLGYSVYRTVLEYYSASNG---------EPDEDAYDMRKALS----RDTEKK----------------------------------------------- G_aculeatus_ENSGACP00000015667 FFVDLFVRVSNQVAV-NMYK-RLGYSVYRTVIEYYSASNG---------EPDEDAYDMRKALS----RDTE------------------------------------------------- C_intestinalis_ENSCINP00000021531 MFVDLFVRKSNQVAV-KMYE-KLGYIVYRTVLDYYSSPNG---------EADEDAYDMRKPTS----WDVNRK----------------------------------------------- A_gambiae_AGAP001878-PA YFVDLFVRVSNKIAI-EMYT-KLGYIVYRTVLEYYVG------------DPDEDAYDMRKACS----RDVHKK----------------------------------------------- A_aegypti_AAEL009373-PA YFVDLFVRVSNKVAI-DMYT-KLGYIVYRTVLEYYVG------------DPDEDAYDMRKACS----RDVHRK----------------------------------------------- E_caballus_ENSECAP00000010421 FFVDLFVRVSNQVAV-NMYK-QLGYSVYRTVIEYYSASNG---------EPDEDAYDMRKALS----RDTEKK----------------------------------------------- G_gorilla_ENSGGOP00000004164 FFVDLFVRVSNQVAV-NMYK-QLGYSVYRTVIEYYSASNG---------EPDEDAYDMRKALS----RDTEKK----------------------------------------------- T_rubripes_ENSTRUP00000039378 FFVDLFVRVSNQVAV-NMYK-RLGYSVYRTVIEYYSASNG---------EPDEDAYDMRKALS----RDTEKK----------------------------------------------- M_musculus_ENSMUSP00000002805 FFVDLFVRVSNQVAV-NMYK-QLGYSVYRTVIEYYSASNG---------EPDEDAYDMRKALS----RDTEKK----------------------------------------------- R_norvegicus_ENSRNOP00000014047 FFVDLFVRVSNQVAV-NMYK-QLGYSVYRTVIEYYSASNG---------EPDEDAYDMRKALS----RDTEKK----------------------------------------------- T_guttata_ENSTGUP00000010800 FFVDLFVRVSNQVAV-NMYK-QLGYSVYRTVLEYYSASSG---------EPDEDAYDMRKALS----RDTEKK----------------------------------------------- M_domestica_ENSMODP00000007334 FFVDLFVRVSNQVAV-NMYK-QLGYSVYRTVIEYYSASNG---------EPDEDAYDMRKALS----RDIEKK----------------------------------------------- C_elegans_Y97E10AL.3 YFVDLFVRVSNKIAI-ELYK-KLGYVVYRQIIGYYTG------------DRDEDAFDMRKSLS----RDPEKK----------------------------------------------- M_mulatta_ENSMMUP00000010124 FFVDLFVRVSNQVAV-NMYK-QLGYKSYLTLILNLPQPTF---------MNLLNVYYMRKALS----RDTEKK----------------------------------------------- S_cerevisiae_YPR131C NFIDLFVKCNNQLAI-KLYE-KLGYSVYRRVVGYYNSAEDGYPDTLKKVDDNKDAFDMRKAMA----RDRNRS----------------------------------------------- D_melanogaster_FBpp0080059 SYVNLFMRISNRAAY-QLYT-SLGYAHRQTFLDYYPDE-----------PKPESAYELRKYVP----RPMEVQ----------------------------------------------- D_melanogaster_FBpp0080033 FYIDLFVREKNTIAI-GLYE-SLGYVKYRWIPKFYAD---------------DHGYEMRLPLS----SDVDRK----------------------------------------------- S_cerevisiae_YPR051W DEIMLETEVENSAAL-NLYE-GMGFIRMKRMFRYYLN--------------EGDAFKLILPLT----EKSCTR----------------------------------------------- A_gambiae_AGAP003917-PA DEVVLETEITNQPAL-RLYE-NLGFVRDKRLFHYYLN--------------GVDALRLKLWFR--------------------------------------------------------- O_anatinus_ENSOANP00000018747 DEVVLETEITNKSAL-KLYE-NLGFVRDKRLFRYYLN--------------GVDALRLKLWLR--------------------------------------------------------- A_aegypti_AAEL012413-PA DEVVLETEITNRPAL-RLYE-NLGFVRDKRLFHYYLN--------------GVDALRLKLWFR--------------------------------------------------------- M_domestica_ENSMODP00000009636 DEVVLETEITNKSAL-KLYE-NLGFVRDKRLFRYYLN--------------GVDALRLKLWLR--------------------------------------------------------- A_carolinensis_ENSACAP00000000646 DEVVLETEITNKSAL-KLYE-NLGFVRDKRLFRYYLN--------------GVDALRLKLWLR--------------------------------------------------------- G_gallus_ENSGALP00000019734 DEVVLETEITNKSAL-KLYE-NLGFVRDKRLFRYYLN--------------GVDALRLKLWLR--------------------------------------------------------- C_familiaris_ENSCAFP00000022463 DEVVLETEITNKSAL-KLYE-NLGFVRDKRLFRYYLN--------------GVDALRLKLWLR--------------------------------------------------------- E_caballus_ENSECAP00000010635 DEVVLETEITNKSAL-KLYE-NLGFVRDKRLFRYYLN--------------GVDALRLKLWLR--------------------------------------------------------- R_norvegicus_ENSRNOP00000020074 DEVVLETEITNKSAL-KLYE-NLGFVRDKRLFRYYLN--------------GVDALRLKLWLR--------------------------------------------------------- H_sapiens_ENSP00000298406 DEVVLETEITNKSAL-KLYE-NLGFVRDKRLFRYYLN--------------GVDALRLKLWLR--------------------------------------------------------- P_troglodytes_ENSPTRP00000010832 DEVVLETEITNKSAL-KLYE-NLGFVRDKRLFRYYLN--------------GVDALRLKLWLR--------------------------------------------------------- D_melanogaster_FBpp0072598 AMIVLETELSNKPAL-ALYQ-SLGFIRERRFLRYYLN--------------GMDAFHLKLMLH----DFIDSS----------------------------------------------- M_mulatta_ENSMMUP00000028074 DEVVLETEITNKSAL-KLYE-NLGFVRDKRLFRYYLN--------------GVDALRLKLWLR--------------------------------------------------------- P_pygmaeus_ENSPPYP00000006647 DEVVLETEITNKSAL-KLYE-NLGFVRDKRLFRYYLN--------------GVDALRLKLWLR--------------------------------------------------------- T_guttata_ENSTGUP00000013437 DEVVLETEITNKSAL-KLYE-NLGFVRDKRLFRYYLN--------------GVDALRLKLWLR--------------------------------------------------------- X_tropicalis_ENSXETP00000026216 DEVVLETEITNKSAL-KLYE-NLGFVRDKRLFRYYLN--------------GVDALRLKLWLR--------------------------------------------------------- B_taurus_ENSBTAP00000017282 DEVVLETEITNKSAL-KLYE-NLGFVRDKRLFRYYLN--------------GVDALRLKLWLR--------------------------------------------------------- M_musculus_ENSMUSP00000041450 DEVVLETEITNKSAL-KLYE-NLGFVRDKRLFRYYLN--------------GVDALRLKLWLR--------------------------------------------------------- D_melanogaster_FBpp0070203 DEVVLETEMRNQPAL-RLYE-NLGFVRDKRLFRYYLN--------------GVDALRLKLWFR--------------------------------------------------------- C_intestinalis_ENSCINP00000010530 DEVVLETEVTNQSAL-NLYE-NLGFIRDKRLFRYYLN--------------GVDALRLKLWLC--------------------------------------------------------- G_aculeatus_ENSGACP00000016825 DEVVLETEITNKSAL-KLYE-NLGFVRDKRLFRYYLN--------------GVDALRLKLWLR--------------------------------------------------------- T_nigroviridis_ENSTNIP00000004980 DEVVLETEITNKSAL-KLYE-NLGFVRDKRLFRYYLN--------------GVDALRLKLWLR--------------------------------------------------------- O_latipes_ENSORLP00000018946 DEVVLETEITNKSAL-KLYE-NLGFVRDKRLFRYYLN--------------GVDALRLKLWLR--------------------------------------------------------- C_elegans_B0238.10 DEIVLETEVSNKNAQ-RLYS-NLGFIRQKRLLKYYLN--------------GGDAFRLKLIFT----SRRVRS----------------------------------------------- T_rubripes_ENSTRUP00000029061 DEVVLETEITNKSAL-KLYE-NLGFVRDKRLFRYYLN--------------GVDALRLKLWLR--------------------------------------------------------- O_cuniculus_ENSOCUP00000013296 FFVDLFVRVSNQVAV-NMYK-QLGYSVYRTVIEYYSASNG---------EPDEDAY---------------------------------------------------------------- B_taurus_ENSBTAP00000010234 GFLYLHVQISNESAI-DFYR-KFGFEIIETKKNYYKR------------IEPADAHVLQKNLK----VPS-------------------------------------------------- O_anatinus_ENSOANP00000018738 DNIYLHVQISNESAI-DFYR-KFGFEVIETKKNYYKR------------IEPADAHVLQKNLK----TPPPL------------------------------------------------ M_domestica_ENSMODP00000022643 DNIYLHVQISNESAI-DFYR-KFGFEIIETKKNYYKR------------IEPADAHVLQKNLK----VPSL------------------------------------------------- A_carolinensis_ENSACAP00000006601 DNIYLHVQISNESAI-DFYR-KFGFEIIETKKNYYKR------------IEPADAHVLQKNLK----VSCL------------------------------------------------- P_troglodytes_ENSPTRP00000051155 DNIYLHVQISNESAI-DFYR-KFGFEIIETKKNYYKR------------IEPADAHVLQKNLK----VPS-------------------------------------------------- E_caballus_ENSECAP00000020661 DNIYLHVQISNESAI-DFYR-KFGFEIIETKKNYYKR------------IEPADAHVLQKNLK----VPS-------------------------------------------------- M_mulatta_ENSMMUP00000039993 DNIYLHVQISNESAI-DFYR-KFGFEIIETKKNYYKR------------IEPADAHVLQKNLK----VPS-------------------------------------------------- G_gallus_ENSGALP00000023856 DNIYLHVQISNESAI-DFYR-KFGFEIIETKKNYYKR------------IEPADAHVLQKNLK----APCL------------------------------------------------- X_tropicalis_ENSXETP00000021826 DNIYLHVQISNESAI-DFYR-KFGFEIIETKKNYYKR------------IEPADAHVLQKNLK----ISSP------------------------------------------------- H_sapiens_ENSP00000240922 DNIYLHVQISNESAI-DFYR-KFGFEIIETKKNYYKR------------IEPADAHVLQKNLK----VPS-------------------------------------------------- P_pygmaeus_ENSPPYP00000015136 DNIYLHVQISNESAI-DFYR-KFGFEIIETKKNYYKR------------IEPADAHVLQKNLK----VPS-------------------------------------------------- T_guttata_ENSTGUP00000013754 DNIYLHVQISNESAI-DFYR-KFGFEIIETKKNYYKR------------IEPADAHVLQKNLK----APCL------------------------------------------------- D_melanogaster_FBpp0087227 DSIFLHVQINNNGAI-EFYK-KFGFEIVDTKEQYYKR------------IEPADAHVLQKTLR----RTAP------------------------------------------------- O_latipes_ENSORLP00000011435 DNIYLHVQISNESAI-DFYQ-KFGFEIIETKKNYYKR------------IEPADAHVLQKSLR----SPCA------------------------------------------------- C_familiaris_ENSCAFP00000015737 DNIYLHVQISNESAI-DFYR-KFGFEIIETKKNYYKR------------IEPADAHVLQKNLK----VPS-------------------------------------------------- D_rerio_ENSDARP00000032139 DNIYLHVQISNESAI-DFYQ-KFGFEIIETKKNYYKR------------IEPADAHVLQKSLR----SPCA------------------------------------------------- 610 620 630 640 650 660 =========+=========+=========+=========+=========+=========+== D_melanogaster_FBpp0076078 ------------AVHRS----------------------------GGHGHSHNHSGHDGHCC A_gambiae_AGAP005410-PC ------------ITNRQ------------------------KGPVVLPHHGDGHAGHDGHCC A_aegypti_AAEL006743-PA -------------------------------------------AVISNHTGGSHAGHDGHCC X_tropicalis_ENSXETP00000046985 CRDEKCM-----GSSGK-----RDLTEDSGDS---KDVSEVSEATESTDVKDSSEASDSAS- D_rerio_ENSDARP00000095595 EKE---------GDGDS-----------GGES---KEMSEVSEATESTDVKDSSSDS----- D_rerio_ENSDARP00000095601 EKE---------GDGDS-----------GGES---KEMSEVSEATESTDVKDSSSDS----- P_troglodytes_ENSPTRP00000027844 CQQ-KNP-----ATEES-----------GSDS---K---EPKESVESTNVQDSSESSDSTS- T_nigroviridis_ENSTNIP00000018147 ERE---------SERDS-----------GGES---KELSEVSEATESTDVKDSSSDSQ---- H_sapiens_ENSP00000286794 CQQ-KNP-----ATEES-----------GSDS---K---EPKESVESTNVQDSSESSDSTS- G_gorilla_ENSGGOP00000012626 CQQ-KNP-----ATEES-----------GSDS---K---EPKQSVESTNVQDSSESSDSTS- C_familiaris_ENSCAFP00000028702 CRDERGL-----AADDS-----------GGDS---KDLSEVSETTESTDVKDSSEASDSAS- G_aculeatus_ENSGACP00000011405 ERE---------NERDS-----------GGES---KELSEVSEATESTDVKDSSSDSQ---- M_musculus_ENSMUSP00000057336 CLP-KNP-----TSKDS-----------GS--------------SDSTDVQDSSEDLDSIS- M_musculus_ENSMUSP00000025463 SQQ-ENL-----AGGDS-----------GSDG---K---------DSTDVQDSLQTLGSAS- O_latipes_ENSORLP00000008862 ERE---------SERDS-----------GGES---KEQSEVSEATESTDVKDSSSDSQ---- H_sapiens_ENSP00000359032 CREEKGL-----AAEDS-----------GGDS---KDLSEVSETTESTDVKDSSEASDSAS- M_mulatta_ENSMMUP00000040755 CREEKGL-----AAEDS-----------GGDS---KDLSEVSETTESTDVKDSSEASDSAS- P_pygmaeus_ENSPPYP00000023349 CREEKGL-----AAEDS-----------GGDS---KDLSEVSETTESTDVKDSSEASDSAS- E_caballus_ENSECAP00000013004 CREEKGL-----AAEDS-----------GGDS---KDLSEVSETTESTDVKDSSEASDSAS- G_gorilla_ENSGGOP00000009559 -------------------------------------------------------------- R_norvegicus_ENSRNOP00000044568 CREEKGL-----TAEDS-----------GGDS---KDLSEVSETTESTDVKDSSEASDSAS- T_rubripes_ENSTRUP00000039218 ERE---------SERDS-----------GGES---KEMSEVSEATESTDVKDSSSDSQ---- M_musculus_ENSMUSP00000033763 CREEKGL-----AAEDS-----------GGDS---KDLSEVSETTESTDVKDSSEASDSAS- B_taurus_ENSBTAP00000017477 CQE-KNP-----ATDGS-----------GSDS---K---EPSESTESPDAQDSSEDSNSTS- M_mulatta_ENSMMUP00000035248 CQQ-KNP-----DTEES-----------GSDS---K---EPKESVESTNVQDSSEGSDSTS- O_cuniculus_ENSOCUP00000008706 CQQENA------AAAVG-----------GSGS-----------KEPSTDVQSSAEDFSSTSW R_norvegicus_ENSRNOP00000002776 CQP-ENP-----AGKGSEACQPENPAGKGSEACQPENPAGKDTGSHSTDVQDSSEYLDSTS- M_domestica_ENSMODP00000014446 CRDERGLGPSPIAEDSS-----------GGDS---KDLSEVSETTESTDVKDSSEASDSAS- A_carolinensis_ENSACAP00000012021 CRDDKCP-----GAVAD-----------SGDS---KDVSEVSEATESTDVKDSSEASDSAS- C_elegans_K07H8.3 ------------KKNRS--------------------------------------------- C_intestinalis_ENSCINP00000013819 IED---------TTEDF-----------VDNENSQSGLSVLAEDNLIKEFKDSASMT----- O_cuniculus_ENSOCUP00000000964 CREEKGL-----AAEDS-----------GGDS---KDLSEVSETTESTDVKDSSEASDSAS- R_norvegicus_ENSRNOP00000056134 CQQENL------AGGDS-----------GSDG------------KDSTDVQD---------- O_anatinus_ENSOANP00000004594 -------------------------------------------------------------- R_norvegicus_ENSRNOP00000049533 CQQENL------AGGDS-----------GNDG------------KDSTDVQD---------- S_cerevisiae_YHR013C ------------LEDDL--------------------ESDLLEDIIKQGVNDIIV------- T_guttata_ENSTGUP00000015789 -------------------------------------------------------------- P_troglodytes_ENSPTRP00000038636 CREEKGL-----AAEDS-----------GGDS---KDLSEVSETTESTDVKDSSEASDSAS- D_melanogaster_FBpp0074532 -------------------------------------SVIPYTQPVRLEHIDMN-------- D_rerio_ENSDARP00000057699 -------------------------------------SIIPLPHPVRPEDIE---------- T_nigroviridis_ENSTNIP00000013627 -------------------------------------SIIPLPHPVRPEDIE---------- C_familiaris_ENSCAFP00000007989 -------------------------------------SIIPLPHPVRPEDIE---------- B_taurus_ENSBTAP00000001522 -------------------------------------SIIPLPHPVRPEDIE---------- H_sapiens_ENSP00000335636 -------------------------------------SIIPLPHPVRPEDIE---------- G_gallus_ENSGALP00000020525 -------------------------------------SIIPLPHPVRPEDIE---------- P_pygmaeus_ENSPPYP00000012011 -------------------------------------SIIPLPHPVRPEDIE---------- P_troglodytes_ENSPTRP00000022806 -------------------------------------SIIPLPHPVRPEDIE---------- O_latipes_ENSORLP00000021581 -------------------------------------SIIPLPHPVRPEDIE---------- A_carolinensis_ENSACAP00000005151 -------------------------------------SIVPLPHPVRPEDIE---------- G_aculeatus_ENSGACP00000015667 -------------------------------------------------------------- C_intestinalis_ENSCINP00000021531 -------------------------------------SIVTEKKVILPEELN---------- A_gambiae_AGAP001878-PA -------------------------------------SVIPLEHPVRPEEVD---------- A_aegypti_AAEL009373-PA -------------------------------------SVIPLTHPVRPDEVD---------- E_caballus_ENSECAP00000010421 -------------------------------------SIIPLPHPVRPEDIE---------- G_gorilla_ENSGGOP00000004164 -------------------------------------SIIPLPHPVRPEDIE---------- T_rubripes_ENSTRUP00000039378 -------------------------------------SIIPLPHPVRPEDIE---------- M_musculus_ENSMUSP00000002805 -------------------------------------SIIPLPHPVRPEDIE---------- R_norvegicus_ENSRNOP00000014047 -------------------------------------SIIPLPHPVRPEDIE---------- T_guttata_ENSTGUP00000010800 -------------------------------------SVIPLPHPVRPEDIE---------- M_domestica_ENSMODP00000007334 -------------------------------------SIIPLPHPVRPEDIE---------- C_elegans_Y97E10AL.3 -------------------------------------AMVPLNYLVHSRDVD---------- M_mulatta_ENSMMUP00000010124 -------------------------------------SIIPLPHPVRPEDIE---------- S_cerevisiae_YPR131C ---------------------------------------------VRPDGRSHKCYPHDVRF D_melanogaster_FBpp0080059 -------------------------------------------------------------- D_melanogaster_FBpp0080033 -----------------------SLEGIIIKKIYSFGNKLYYLLMFYIFGIIAIVIGGILVE S_cerevisiae_YPR051W ------------------------------------STFLMHGRLAT--------------- A_gambiae_AGAP003917-PA -------------------------------------------------------------- O_anatinus_ENSOANP00000018747 -------------------------------------------------------------- A_aegypti_AAEL012413-PA -------------------------------------------------------------- M_domestica_ENSMODP00000009636 -------------------------------------------------------------- A_carolinensis_ENSACAP00000000646 -------------------------------------------------------------- G_gallus_ENSGALP00000019734 -------------------------------------------------------------- C_familiaris_ENSCAFP00000022463 -------------------------------------------------------------- E_caballus_ENSECAP00000010635 -------------------------------------------------------------- R_norvegicus_ENSRNOP00000020074 -------------------------------------------------------------- H_sapiens_ENSP00000298406 -------------------------------------------------------------- P_troglodytes_ENSPTRP00000010832 -------------------------------------------------------------- D_melanogaster_FBpp0072598 ------------------------------------LNE----------------------V M_mulatta_ENSMMUP00000028074 -------------------------------------------------------------- P_pygmaeus_ENSPPYP00000006647 -------------------------------------------------------------- T_guttata_ENSTGUP00000013437 -------------------------------------------------------------- X_tropicalis_ENSXETP00000026216 -------------------------------------------------------------- B_taurus_ENSBTAP00000017282 -------------------------------------------------------------- M_musculus_ENSMUSP00000041450 -------------------------------------------------------------- D_melanogaster_FBpp0070203 -------------------------------------------------------------- C_intestinalis_ENSCINP00000010530 -------------------------------------------------------------- G_aculeatus_ENSGACP00000016825 -------------------------------------------------------------- T_nigroviridis_ENSTNIP00000004980 -------------------------------------------------------------- O_latipes_ENSORLP00000018946 -------------------------------------------------------------- C_elegans_B0238.10 ------------------------------------LNNQENYQPRCRVNEDDTPDEEEGTY T_rubripes_ENSTRUP00000029061 -------------------------------------------------------------- O_cuniculus_ENSOCUP00000013296 -------------------------------------------------------------- B_taurus_ENSBTAP00000010234 -------------------------------------GQNADVQKTDN-------------- O_anatinus_ENSOANP00000018738 -------------------------------------GQSTDVQKLDN-------------- M_domestica_ENSMODP00000022643 -------------------------------------GQNADVQKTDN-------------- A_carolinensis_ENSACAP00000006601 -------------------------------------GQNTDVQKSDN-------------- P_troglodytes_ENSPTRP00000051155 -------------------------------------GQNADVQKTDN-------------- E_caballus_ENSECAP00000020661 -------------------------------------GQNADVQKTDN-------------- M_mulatta_ENSMMUP00000039993 -------------------------------------GQNADVQKTDN-------------- G_gallus_ENSGALP00000023856 -------------------------------------GQNADVQKTDN-------------- X_tropicalis_ENSXETP00000021826 -------------------------------------GQNADVLKSEN-------------- H_sapiens_ENSP00000240922 -------------------------------------GQNADVQKTDN-------------- P_pygmaeus_ENSPPYP00000015136 -------------------------------------GQNADVQKTDN-------------- T_guttata_ENSTGUP00000013754 -------------------------------------GQNADVQKTDN-------------- D_melanogaster_FBpp0087227 -------------------------------------NSNSTATSTTANSNSRSKARQFTFV O_latipes_ENSORLP00000011435 -------------------------------------QPSGELQKTE--------------- C_familiaris_ENSCAFP00000015737 -------------------------------------GQNADVQKTDN-------------- D_rerio_ENSDARP00000032139 -------------------------------------PPAGELQKAD---------------