>D_melanogaster_FBpp0082755 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MDDTDFS LFGQKNKHKKDKADATK------------------------------------------- ------------------------------------------------------------ ------------------------IAHTPTSELDLKR--III----SRP--TNEDTYE-N CARAGIALILNHKDVK----------GQKQRVGTERDRDD-MEATLQGFGFD-VRTFDDL TFSEINDTLKEVARE-DHSQNDCFVLAVMSHGTE-------GK-VYAKDM-SYPVERLWN PFLGDNCKTLKNKPKLFFIQ--ACR----GANL-EKAV----EF-----SSF-AVMTREL VPEPAA--------------A-V--------------------QPI-TYAIPSTADILVF YSTFD--KFFSFRNVDDGSWFIQSLCRVLDQAAANEAATPEGVELL-----------RLL TAVNRKVAYEY---QSNTKN-EALNQMKEMPNFMSTLTKTFQLRVK--PKT--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_aegypti_AAEL003444-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MDTTDELDVLG------------------------------------------- ------------------------------------------------------------ -----------------------FGSRTNESSKSIKE--ALV----SRA--ALDEYYDTT NKRRGIALVFCHMNFS----------VMAKRNGADKDRDD-ICNTLYGLDFD-VRVFDDL SRKEVLDRLKDVSRE-DHSDNDCLVVVMMSHGEQ-------GV-LYARDN-KYNVDSLWK NFVGNACPSLIGKPKMFFIQ--ACR----GEQF-DEGV----AY-----AAK-SPK---- -DMVDS--------------R-Q--------------------EQV-LYSIPAMADLLVM YSTYD--GYYSWRNPRQGSWFIQSLCTELDENG-------RVRDLL-----------TLL TGVSRRTAYEF---QSFVPHNAKMDAMKQIPCIVSMLTKTFYFTKK--TRSRVVTDID-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_gambiae_AGAP011951-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ECYDTS NARRGIALIINQVIFS----------SMAVRVGSSKDRTD-ISTVLQRIGFE-VRVMDDP NRKQLLSALKQLAGE-DHSHSDCLVVVVMTHGKE-------NNLLYASDK-SYEANQLWE PFIGDACPSLIGKPKLFFVQ--ACR----GKKL-DEGV----IQ------AT-ISI---- -DSVDTQS------------S-P--------------------GSM-RYVIPAMADLLVM YSTYD--GHYSWRNPSKGSWFIQSLCAELGASA-------HCKELL-----------HIL TAVSRRVAYHY---QSNVPDNAKIDAKKQMPCMVSMLTKLLYLRPK--K----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_gambiae_AGAP011952-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ENYDTS HRNRGTALIFNHVNFE----------SNAKREGSNKDRDE-IKKELLQLGFD-ARVFNDL KKQELLAKLDEVAKE-DHTESDCFVLVMMTHGQD-------GS-LYAADK-QYQIAELWE PFVGDACKTLIGKPKLFFVQ--ACR----GTKF-DKGV----KL------TK-IAT---- -DTVDALS------------S-S--------------------SQR-TCVIPTMADVLVM YSAFD--GHYSWRNPTHGSWFIQSLSIELNQHA-------HRKELL-----------QLL TSVSRRVAYLY---ESNVPGNEQMDGKKQMPCVVSMLTKALYFPRK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_gambiae_AGAP004920-PA ------------------------------------------------------------ --------------------VCGRDI-----------------LHCKTMNT--------- ------------------------------------------------------------ ------------------------------------------------------------ STLSTAFDEVDNNTRVLS------------------------------------------ ------------------------------------------------------------ -----------------------LVASVPEI-ISSSV--IHE----LEP--VDDAHYNMS HNRRGVAAVFNHRKFL----------HASERKGTDADCDN-IRQVLIYLQFE-VRVYDDL TRKEIKQVLDDLAEE-DHKNSDCLLVVIMTHGDD-------DV-LHAKDG-TFNVDRLWE NFIGDSCPSLLGKPKLFFIQ--ACR----GSSF-DTGV----HF------SQ-CMT---- -QVA----------------K-TVVPYAMRELPQPSIVPGCPKSSI-QYAIPSMADLLVM YSTYK--GHYSWRNPSTGSWFIRALCDELREHG-------NSKELL-----------QLL TSVSRRVAYEF---QSNVPNNSQIDCQKQMPCIVSMLTRRIYFSKK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_gambiae_AGAP004921-PA ------------------------------------------------------------ -------------------------------------------RSCNLMDD--------- ------------------------------------------------------------ ------------------------------------------------------------ LPPEPTPDNEFYDGNIPS------------------------------------------ ------------------------------------------------------------ ------------------------ITQTDQI-ASRQR--SQN----ARA--LQEEEYDTN HRRRGMAIILNHENFE----------LMSKREGTNRDRDA-ATAVLTSMQFD-VRVYNDL GRDELFCVLLALASE-DHSDCDCLLVMLMTHGDD-------DV-LYAYDG-PYSVDKLWE SFMGNACTTLLGKPKLFFVQ--ACR----GSTF-DKGV----KL------GC-RDL---- -DSD----------------H-F--------------------SSH-KYVIPTTADLLVM YSSYK--GHVSWRSPRGGSWFIQALCVELETNW-------KHMELL-----------QLL TGVSRRVAYDY---QSNEPSKGRMDAMKQMPSIVSMLTKLVYFPLK-------------- -------------------------------------L---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GS----- >A_gambiae_AGAP000830-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------MSMPDVVDIRNEINKEHVRE---SLDRNGDE QQ-----LVQDVNDALG------------------------------------------- -----------------------------------------------------T------ ---------------------RKGHDPTNHLVR---ARMPVE---------RYACDYNMN HKRRGLALIFNHENFD--------VPQLRSRAGTNVDCEN-LTASLKGLDFE-VHVFKDL KLRDLQKEVERVSQM-DHSDADCLLVTILSHGEL-------GY-LYAKDC-QYKLDTIWT YFTANHCPSLAGKPKLFFIQ--ACQ----GDQL-DGGV----VL-----EAK-DRTET-- --------------------DSS--------------------SSMLTFKIPMYADFMIA YSTIP--GFYSWRNTQKGSWFIQSLCHELNQNG-------RKYDLM-----------VLL TFVTQRVAYDF---ESNTPDIPMMHQQKQIPCTTSMLTRLVYFNQK--K----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_aegypti_AAEL003439-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MDTADELDVLG------------------------------------------- ------------------------------------------------------------ -----------------------FGNKTNESSTSNEN--RPL----SRP--TCDEYYDMS NKRRGIALVFCHMNFAV----------MAKRNGTDKDRDD-ICSTLSGLDFD-VRVFNDL RRKELLRTLKNVSRE-DHSENDCLVVVVMSHGDQ-------GV-LYASDK-KYYVDSLWE KFTGNACPSLIGKPKLFFVQ--ASRERQPGKKG-EGGR----EE-----ESQ-ASV---- -DVVDSP-------------N-D--------------------SSA-LYFIPTMADFLVM YSTYD--GYYSGKDPLQRSCLIQSLCMELDENG-------RERDLL-----------ALL TGVSRRALYTC---ESSVPHNEKDNALKPIPCVVSMLTKTFFFTKK--T----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_gambiae_AGAP011949-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MDS----ILE--FELKSYDTT HPNRGIAVVINDS---------------ERREGSEKDVQD-VVATLEGLKFN-VRTFQDN TKKEIKKALYKVARE-DHNENDCLVIVAMAHGKK-------DH-ITLKKE-KLRIDKLWA SFVGNKCPSLIGKPKLVFIQ--TCR----GDNV-DFGVAS-HET-----DST-PCS---- ----------------------V--------------------DPA-PGIIPMYADLLVM YSSYD--RHISVRCKDKGSWFIQSLCQVLRANI-------AGKELI-----------SLL TQVSYIVSCQT---S----ITSDGETVKQIPSINSMLTKAFYFVPK--QTQQIS------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_domestica_ENSMODP00000005556 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MEDTGTTVDAKS------------------------------------------- ------------------------------------------------------------ ---------------TKNSG---VKLFHGSKSVESGL---------------SSDSYKMD YPEMGLCIIINNKNFH-------PNTGMSFRSGTDVDAAS-LSDTFRSLKYE-VRIKNDL TCNEITELLNSVSKE-DHSQRSSFICVILSHGEE-------GV-IFGTDR-SVELKRLTC FFRGDKCRSLTGKPKLFIIQ--ACR----GTEL-DCGV----ET-----DSG-TD----- ----------------------E--------------------DIA-CQKIPVEADFLYA YSTAP--GYYSWRNSKDGSWFIQALCAVLKQHA-------HKLEIM-----------QIL TRVNRKVATEF---ESYSLD-ISFHAKKQVPCIMSMLTKELYFSH--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >X_tropicalis_ENSXETP00000003217 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ME ESHNGVQYGEDTADAKT------------------------------------------- ------------------------------------------------------------ --------------YFTNQQISLQNCDIKDMEKKTKF--------------AHLHKYRTD YPEMGICLIINNKNFQ-------SSTNMGVRNGTDVDARK-LHETFTGLGYK-VKVCNDQ KSNDIFTLLKKMSEE-DHSKRSSFVCAILSHGED-------GL-VYGVDG-PIQIKNLTD LFRGDRCKTLVGKPKLFFIQ--ACR----GTDL-DSGI----ET-----DSG-SE----- ----------------------P--------------------GEE-IQRIPVEADFLYA YSTVP--GYYSWRNTMNGSWFIQSLCEMIKLYG-------PHLELI-----------QIL TCVNHMVALEF---ESCSTQ-QAFHAKKQIPCVVSMLTKAFYFLK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------PTFRYRMD YKKLGKCVIINNKNFA-------KDTGMRIRNGTDKDAGD-LQKCFRGIGFD-VSIYNDL TCDNMEKILGEAALE-NHDDAACFACILLSHGEE-------GL-IYGTDG-CMAIKNLTG LFRGDKCQSLIGKPKLFFIQ--ACR----GSEF-DAGI----QT-----DSG-SSN-DNL EM--------------------D--------------------ANP-RYKIPVEADFLYA YSTVP--GYFSWRNPGKGSWFVQSLCSVLNDHG-------KELEVL-----------QIL TMVNYKVARNY---ESQSDD-PRFSQKKQVPCVVSMLTKELYF----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IPVSKSVDSVI--------------EADESYRMD HPEMGLCILVNNKNFH-------PATGMSYRSGTDRDAAH-VVDTFRTLGYM-VKPYNDL TCKQIVDVLHNVSKD-DHHKRNSFVCVLLSHGED-------GL-IYGTDG-HVELKMLTS FFRGDKCKSLAGKPKLFFIQ--ACR----GTEL-DSGI----ET-----DSA-S------ ----------------------D--------------------ESM-CQKIPVEADYLYA YSTAP--GYYSWRNSSDGSWFIQSLCSMLKQYS-------HKLELM-----------QIL TRVNRKVT-EF---TSCSNH-PDFHGKKQIPCIMSMLTKDFYFPH--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_troglodytes_ENSPTRP00000005216 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MDCVGWPPGRKWHLEKNTSCGGSSGICASYVTQMADDQGCIE EQGVEDSANEDSVDAKP------------------------------------------- ------------------------------------------------------------ ---DRSSFVPSLFS-KKKKNVTM-----RSIKTTRDR--------------VPTYQYNMN FEKLGKCIIINNKNFD-------KVTGMGVRNGTDKDAEA-LFKCFRSLGFD-VIVYNDC SCAKMQDLLKKASEE-DHTNAACFACILLSHGEE-------NV-IYGKDG-VTPIKDLTA HFRGDRCKTLLEKPKLFFIQ--ACR----GTEL-DDGI----QA-----DSG-PIN-D-- -T--------------------D--------------------ANP-RYKIPVEADFLFA YSTVP--GYYSWRSPGRGSWFVQALCSILEEHG-------KDLEIM-----------QIL TRVNDRVARHF---ESQSDD-PRFHEKKQIPCVVSMLTKELYFSQ--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >H_sapiens_ENSP00000358327 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MDCVGWPPGRKWHLEKNTSCGGSSGICASYVTQMADDQGCIE EQGVEDSANEDSVDAKP------------------------------------------- ------------------------------------------------------------ ---DRSSFVPSLFS-KKKKNVTM-----RSIKTTRDR--------------VPTYQYNMN FEKLGKCIIINNKNFD-------KVTGMGVRNGTDKDAEA-LFKCFRSLGFD-VIVYNDC SCAKMQDLLKKASEE-DHTNAACFACILLSHGEE-------NV-IYGKDG-VTPIKDLTA HFRGDRCKTLLEKPKLFFIQ--ACR----GTEL-DDGI----QA-----DSG-PIN-D-- -T--------------------D--------------------ANP-RYKIPVEADFLFA YSTVP--GYYSWRSPGRGSWFVQALCSILEEHG-------KDLEIM-----------QIL TRVNDRVARHF---ESQSDD-PHFHEKKQIPCVVSMLTKELYFSQ--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >D_melanogaster_FBpp0071971 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------M------------TDECVTRNYGVGIRSPNG SENRGSFIMADNTDAKG------------------------------------------- -----------------------------------------------------C------ TPESLVVGGATA-------------ASPLPA-NKFVARMPVE---------RYASEYNMS HKHRGVALIFNHEFFD--------IPSLKSRTGTNVDAQE-LKKAFENLGFA-VSVHKDC KLRDILKHVGKAAEL-DHTDNDCLAVAILSHGEH-------GY-LYAKDT-QYKLDNIWH YFTATFCPSLAGKPKLFFIQ--ACQ----GDRL-DGGI----TL-----E-K-GVTET-- --------------------DGE--------------------SST-SYKIPIHADFLFS YSTIP--GYFSWRNINNGSWYMQSLIRELNANG-------KKYDLL-----------TLL TFVNQRVALDF---ESNVPATPMMDRQKQIPCLTSMLTRILRFGDK--PNGNKAG----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_cuniculus_ENSOCUP00000009498 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MADDQAHAG ELGAGDSESADAVDAKP------------------------------------------- ------------------------------------------------------------ ---DRSSFVPALFS-KKKKNGPK-----QSAKATRDQ--------------VPSYQYNMN FDKMGKCIIINNKNFD-------KVTGMGVRNGTDKDAEA-LFKCFRSLGFD-VMVYNDC SCARMQDLLKRASEE-DHTNSACFACILLSHGEE-------NL-IYGKDG-VIPIKDLTA HFRGDRCKTLLEKPKLFFIQ--ACR----GTEL-DDGI----QA-----DSG-PIN-D-- -T--------------------D--------------------ANP-RHKIPVEADFLFA YSTVP--GYYSWKNPGRGSWFVQALCSILDEHG-------KELEVM-----------QIL TRVNDRVARHF---ESQSDD-PRFNEKKQIPCVVSMLTKELYFCR--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_gallus_ENSGALP00000014503 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------KKKNGEEEQPKSSLSNQYRIV--------------TPTFQYNMN YKKVGKCIIINNKNFE-------DKTGMGTRNGTDKDAGD-LSKSFRSLGFD-VYTYNDR SCEDMQTLLKQAAEE-NHSDAACFACILLSHGEE-------GL-IYGTDG-PMAIKHLTT LFRGDKCKTLIGKPKLFFIQ--ACR----GSEF-DEGI----QT-----DSG-PAN-DTL ET--------------------D--------------------ANP-RYKIPVEADFLFA YSTVP--GYYSWRNPGRGSWFVQSLCSVLNEHG-------KQLEIM-----------QIL TRVNYVVATNF---ESQSDD-PRFSEKKQIPCVVSMLTKELYF----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_anatinus_ENSOANP00000000517 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----AASGEVMVDSKS------------------------------------------- ------------------------------------------------------------ ---------------FHSSQGYSSRKVPGKQFLGSSA--------------SLDDRYRMD YPNMGICLIINNKNFH-------PDTRMGCRSGTDVDAAS-LRDTFKKLKYE-VRCKNDL KRREILELLTSVAHE-DHSKRSSFVCVLLSHGEE-------GV-IFGTDG-SLELKSLAS LFRGDNCRSLVGKPKLFIVQ--ACR----GTEL-DSGV----EA-----DSS-SA----- ----------------------D--------------------DGS-EQKIPVEADFLYA YSTAP--GYYSWRNSMNGSWFIQALCAMLKQHA-------HTLELL-----------HIL TRVNRKVATEF---ESYSLD-ATFNAKKQIPCIVSMLTKELYFPY--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_mulatta_ENSMMUP00000001627 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------S-KKKKNVSG-----QSIKTTRDR--------------VPTYQYNMN FEKMGKCIIINNKNFD-------KVTGMGVRNGTDKDAEA-LFKCFQSLGFD-VIVHNDC SCAKMKDLLKKASEE-DHTNAACFACILLSHGEE-------NL-IYGKDG-VTPIKDLTA HFRGDRCKTLLEKPKLFFIQ--ACR----GTEL-DDGI----QA-----DSG-PIN-D-- -T--------------------D--------------------ANP-RYKIPVEADFLFA YSTVP--GYYSWRSPGRGSWFVQALCSILEEHG-------KDLEIM-----------QIL TRVNDRVARHF---ESQSDD-PCFHEKKQIPCVVSMLTKELYFSH--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_pygmaeus_ENSPPYP00000003106 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MDCVGWPPGRRWHLEKNTSCSGSSGICASYVTQMADDQGCVE EQGLGDSANEDSVDAKP------------------------------------------- ------------------------------------------------------------ ---DRSSFVPFLFS-MKKKNVSM-----QSIKTTRDR--------------VPTYQYNMN FEKLGKCIIINNKNFD-------KVTGMGVRNGTDKDAEA-LFKCFRSLGFD-VIVYNDC SCAKMQDLLKKASEE-DHTNAACFACILLSHGEE-------NL-IYGKDG-VTPIKDLTA HFRGDRCKTLLEKPKLFFIQ--ACR----GTEL-DDGI----QA-----DSG-PIN-D-- -T--------------------D--------------------ANP-RYKIPVEADFLFA YSTVP--GYYSWRSPGRGSWFVQALCSILEEHG-------KDLEIM-----------QIL TRVNDRVARHF---ESQSDD-PRFHEKKQIPCVVSMLTKELYFSQ--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >R_norvegicus_ENSRNOP00000022693 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MTDDQDCAA ELEMADSSTEDGVDAKP------------------------------------------- ------------------------------------------------------------ ---DRSTIISSLLW-KKKKNASM-----CPVSTTRDR--------------VPTYLYRMD FEKMGKCIIINNKNFD-------KATGMDVRNGTDKDAEA-LFKCFRSLGFE-VTVYNDC SCAKMQDLLRRASEE-DHSNSACFACVLLSHGEE-------NL-IYGKDG-VTPIKDLTA HFRGDRCKTLLEKPKLFFIQ--ACR----GTEL-DDGI----QA-----DSG-PIN-D-- -T--------------------D--------------------ANP-RYKIPVEADFLFA YSTVP--GYYSWRNPGKGSWFVQALCSILNEHG-------KDLEIM-----------QIL TRVNDRVARHF---ESQSDD-PRFNEKKQIPCMVSMLTKELYFGR--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_gallus_ENSGALP00000017288 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MMT DIKDGPRSGEDVSDARS------------------------------------------- ------------------------------------------------------------ ---------------FPGSK---GMNLPASKSVDSGI--------------LPDDSYRMD YPEIGVCVIINNKNFH-------RDTGLSSRSGTDADAAS-VREVFMKLGYK-VKLNNDL SSRDIFKLLKNVSEE-DHSKRSSFVCVLLSHGDE-------GL-FYGTDG-PLELKVLTS LFRGDKCRSLAGKPKLFFIQ--ACR----GTEL-DSGI----EA-----DSG-P------ ----------------------D--------------------ETV-CQKIPVEADFLYA YSTAP--GYYSWRNAAEGSWFIQSLCRMLKEHA-------RKLELM-----------QIL TRVNRRVA-EY---ESCSTR-QDFNAKKQIPCIVSMLTKEFYFPC--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >B_taurus_ENSBTAP00000008706 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------S-KKKKNDSG-----KSVNIPRDR--------------VPTYQYNMN FEKVGKCIIINNKNFD-------RITGMGVRNGTDKDAEA-LFKCFRSLGFD-VSVYNDC SCAKMQDLLKKASEE-DHRNSACFACILLSHGEE-------NL-IYGTDG-KTAIKDLTA HFRGDRCKTLLEKPKLFFIQ--ACR----GTEL-DDGI----QA-----DSG-PIN-D-- -T--------------------D--------------------ANP-RYKIPVEADFLFA YSTVP--GYYSWRNPGSGSWFVQALCSILNEHG-------KSLEIL-----------QIL TRVNDRVARHF---ESQSDD-PRFHEKKQIPCVVSMLTKELYF----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_gambiae_AGAP011950-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MDS----LLE--LELQSYKTN HPNRGIAVVINDS---------------ENRDGWEKDLEA-VETVLQRLKCD-VRTFCDK TKHEIRDALRNVSKE-DHTKSDCLVIVAMAHGNN-------DK-ITLRRG-EMHIDELWT DFVGNGCPSLIGKPKLVFIQ--SCR----GNKH-DYLVGG-AAV-----DAV-PSP---- ----------------------E--------------------KPI-CVEIPMYADLLVM YSSYD--QYVSYRDKEEGSWFIQSLCQVLGANI-------AGKDLL-----------TLL THVSYLVSVRSFLMESEVNMVKRTGVLKQIPSINSMLTKAFYFVDK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >E_caballus_ENSECAP00000013731 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MADDQDCVV EQGAGDSTSTDAVDAKP------------------------------------------- ------------------------------------------------------------ ---DRSSFVPSLFS-KKKKNGPE-----RSITTNRNR--------------EPTYQYNMN FEKVGKCVIINNKNFD-------RGTGMGVRNGTDKDAEA-LFKCFRNLGFD-VVVYNDC SCAKMKSLLKQASEE-DHRNSACFACILLSHGEE-------NL-IYGTDG-MTPIKDLTG HFRGDRCKTLLEKPKLFFIQ--ACR----GTEL-DDGI----QA-----DSG-PINDD-- -T--------------------D--------------------ANP-RYKVPVEADFLFA YSTVP--GYYSWRNPGSGSWFVQALCSILNEHG-------KSLEII-----------QIL TRVNHRVARHF---ESHSDD-PRFHQKKQIPCVVSMLTKELYF----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_pygmaeus_ENSPPYP00000017020 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MENTENSVDSKS------------------------------------------- ------------------------------------------------------------ ---------------IKNLE---PKVIHGSKSMDSGI--------------SLDNSYKMD YPEMGLCIIINNKNFH-------KSTGMASRSGTDVDAAN-LRETFRNLKYE-VRNKNDL TREEIVELMRDVAKE-DHSKRSSFVCVLLSHGEE-------GI-IFGTNG-PVDLRKITN FFRGDRCRSLTGKPKLFIIQ--ACR----GTEL-DCGI----ET-----DSG-VD----- ----------------------D--------------------DMA-CHKIPVEADFLYA YSTAP--GYYSWRNSKDGSWFIQSLCAMLKQYA-------DKLEFM-----------HIL TRVNRKVATEF---ESFSLD-ATFHAKKQIPCIVSMLTKELYFYH--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_nigroviridis_ENSTNIP00000022078 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MAGEAAGIPELG GEAEGEHRCEDDVDAKP------------------------------------------- ------------------------------------------------------------ ---DRRGRFLLFKS-KKKNDGQMREQDYCSESHYRIV--------------SPTFQYRMS HQRVGKCIIINNKNFD-------EKTGMNVRNGTDRDAGE-LYKCFKSLGFD-VFIYNDQ TCEKMEHLLREASEE-DHSDSSCFACILLSHGEE-------GM-IYGTDG-AMPIKTMTS MFRGDMCKSLVGKPKLFFIQ--ACR----GSEF-DDGI----QT-----DSG-PPN-DTM ET--------------------D--------------------ANP-RHKIPVEADFLFA YSTVP--GYYSWRNPGRGSWFVQALCNVLNEFG-------KQLEIM-----------QIL TRVNYMVATSF---ESWSED-PRFSEKKQIPCVVSMLTKELYFKPC-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >D_melanogaster_FBpp0084848 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------MDATN--------NGESADQ---VGIRVGNP EQ------PNDHTDALG------------------------------------------- -----------------------------------------------------SVGSGGA GSSGLVAGSSHPYGSGAIGQLANGYSSPSSSYRKNVAKMVTD---------RHAAEYNMR HKNRGMALIFNHEHFE--------VPTLKSRAGTNVDCEN-LTRVLKQLDFE-VTVYKDC RYKDILRTIEYAASQ-NHSDSDCILVAILSHGEM-------GY-IYAKDT-QYKLDNIWS FFTANHCPSLAGKPKLFFIQ--ACQ----GDRL-DGGV----TM-----Q-R-SQTET-- --------------------DGD--------------------SSM-SYKIPVHADFLIA YSTVP--GFYSWRNTTRGSWFMQSLCAELAANG-------KRLDIL-----------TLL TFVCQRVAVDF---ESCTPDTPEMHQQKQIPCITTMLTRILRFSDK--QLAPAGRV---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MENTENSVDSKS------------------------------------------- ------------------------------------------------------------ ---------------IKNLE---PKIIHGSQSMDSGI--------------SLDNSYKMD YPEMGLCIIINNKNFH-------KSTGMTSRSGTDVDAAN-LRETFRNLKYE-VRNKNDL TREEIVELMRDVSKE-DHSKRSSFVCVLLSHGEE-------GI-IFGTNG-PVDLKKITN FFRGDRCRSLTGKPKLFIIQ--ACR----GTEL-DCGI----ET-----DSG-VD----- ----------------------D--------------------DMA-CHKIPVEADFLYA YSTAP--GYYSWRNSKDGSWFIQSLCAMLKQYA-------DKLEFM-----------HIL TRVNRKVATEF---ESFSFD-ATFHAKKQIPCIVSMLTKELYFYH--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >H_sapiens_ENSP00000311032 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MENTENSVDSKS------------------------------------------- ------------------------------------------------------------ ---------------IKNLE---PKIIHGSESMDSGI--------------SLDNSYKMD YPEMGLCIIINNKNFH-------KSTGMTSRSGTDVDAAN-LRETFRNLKYE-VRNKNDL TREEIVELMRDVSKE-DHSKRSSFVCVLLSHGEE-------GI-IFGTNG-PVDLKKITN FFRGDRCRSLTGKPKLFIIQ--ACR----GTEL-DCGI----ET-----DSG-VD----- ----------------------D--------------------DMA-CHKIPVEADFLYA YSTAP--GYYSWRNSKDGSWFIQSLCAMLKQYA-------DKLEFM-----------HIL TRVNRKVATEF---ESFSFD-ATFHAKKQIPCIVSMLTKELYFYH--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------STKKKKTEDPEKPPQASDNVRIV--------------TPAFQYKMN YGKVGRCIIINNKNFD-------DITGMSPRNGTDIDARD-LLRCFKGLGFD-VTVFNNK SCTEMETLLRSVAEQ-DHKDSACFACIFLSHGEE-------GL-IYGTDG-AMPIKVLTT LFRGDKCRSLVGKPKLFFIQ--ACR----GCEF-DDGL----ET-----DAG-PSN-DSL ET--------------------D--------------------ANP-RHKIPVEADFLYA YSTVP--GYYSWRNPGRGSWFVQALCNVLNEHG-------KELEVM-----------QIL TRVNYLVATQF---ESYCDD-PQFNKKKQIPCVVSMLTKELYFKPC-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_gorilla_ENSGGOP00000007184 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MADDQGCVX XXXXXXXXXXXXXXXXX------------------------------------------- ------------------------------------------------------------ ---XXXXXXXXXXX-XXXXXXXX-----XXXXXXXXX--------------XXXXXXXXX XXXXXXXXXXXXXXFD-------KVTGMGVRNGTDKDAEA-LFKCFRSLGFD-VIVYNDC SCAKMQDLLKKASEE-DHTNAACFACILLSHGEE-------NV-IYGKDG-VTPIKDLTA HFRGDRCKTLLEKPKLFFIQ--ACR----GTEL-DDGI----QA-----DSG-PIN-D-- -T--------------------D--------------------ANP-RYKIPVEADFLFA YSTVP--GYYSWRSPGRGSWFVQALCSILEEHG-------KDLEIM-----------QIL TRVNDRVARHF---ESQSDD-PRFHEKKQIPCVVSMLTKELYFSQ--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_guttata_ENSTGUP00000006879 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MT DIGDGAHLGKDLADTKS------------------------------------------- ------------------------------------------------------------ ---------------IPGFK---GKNLPASKSMDSGI--------------LPDYSYRMD YPEMGECIIINNKNFH-------RYTGMSPRSGTDADAAS-VREVFMKLGYK-IKINNDL SCEGIFNLLKNVSEE-DHSKRSSFVCVLLSHGDE-------GL-IYGTDG-PLELKALTS LFRGDRCRSLAGKPKFFFIQ--ACR----GTEL-DSGI----ET-----DSG-S------ ----------------------E--------------------ETM-CQKIPVEADFLYA YSTAP--GYYSWRNSAEGSWFIQSLCKMLKEHA-------RKLELM-----------QIL TRVNRRVA-EY---ESCSTR-QDFNAKKQIPCIVSMLTKEFYFPS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_aculeatus_ENSGACP00000008661 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------QVNGARLTSAQDVA --AEEGGPTGDQTDAKP------------------------------------------- ------------------------------------------------------------ ---DRRGRFLLFGNIKKNKDGQTREQDYSSESHYRVV--------------SPTFQYKMS HQRVGKCIIINNKNFD-------EKTGMNVRNGTDRDAGE-LFKCFKSLGFD-VFIYNDQ TCGKMESLLREASEE-DHSDSSCFACILLSHGEE-------GM-IYGTDA-AMPIKSMTS LFRGDMCKSLVGKPKLFFIQ--ACR----GSEF-DDGI----QT-----DSG-PPN-DTL ET--------------------D--------------------ANP-RHKIPVEADFLFA YSTVP--GYYSWRNPGRGSWFVQALCNVLNEFG-------KQLEIM-----------QIL TRVNYMVATSF---ESWSED-PRFSEKKQIPCVVSMLTKELYFN---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_familiaris_ENSCAFP00000016420 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MADDQDCGM EQAAGDSESPDAVDARP------------------------------------------- ------------------------------------------------------------ ---DRSSFVPSLFS-RKKKNDSG-----RSIKTAQDQ--------------VPTYQYNMN FEKVGKCIIINNKNFD-------KTTGMGVRNGTDKDAEA-LFKCFRNLGFD-VVIYNDC SCAKMQDLLKKASEE-DHRNSACFACILLSHGEE-------NL-IYGTDG-MTAIKDLTA HFRGDRCRTLLEKPKLFFIQ--ACR----GTEL-DDGV----QA-----DSG-PIN-D-- -T--------------------D--------------------ANP-RYKIPVEADFLFA YSTVP--GYYSWRSPGSGSWFVQALCSTLNEHG-------KSLEIL-----------HIL TRVNNRVARHF---ESQSDD-PHFHEKKQIPCVVSMLTKELYF----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_musculus_ENSMUSP00000026062 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MTDDQDCAA ELEKVDSSSEDGVDAKP------------------------------------------- ------------------------------------------------------------ ---DRSSIISSILL-KKKRNASA-----GPVRTGRDR--------------VPTYLYRMD FQKMGKCIIINNKNFD-------KATGMDVRNGTDKDAGA-LFKCFQNLGFE-VTVHNDC SCAKMQDLLRKASEE-DHSNSACFACVLLSHGEE-------DL-IYGKDG-VTPIKDLTA HFRGDRCKTLLEKPKLFFIQ--ACR----GTEL-DDGI----QA-----DSG-PIN-D-- -I--------------------D--------------------ANP-RNKIPVEADFLFA YSTVP--GYYSWRNPGKGSWFVQALCSILNEHG-------KDLEIM-----------QIL TRVNDRVARHF---ESQSDD-PRFNEKKQIPCMVSMLTKELYFSR--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_musculus_ENSMUSP00000091238 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MENNKTSVDSKS------------------------------------------- ------------------------------------------------------------ ---------------INNFE---VKTIHGSKSVDSGI--------------YLDSSYKMD YPEMGICIIINNKNFH-------KSTGMSSRSGTDVDAAN-LRETFMGLKYQ-VRNKNDL TREDILELMDSVSKE-DHSKRSSFVCVILSHGDE-------GV-IYGTNG-PVELKKLTS FFRGDYCRSLTGKPKLFIIQ--ACR----GTEL-DCGI----ET-----DSG-TD----- ----------------------E--------------------EMA-CQKIPVEADFLYA YSTAP--GYYSWRNSKDGSWFIQSLCSMLKLYA-------HKLEFM-----------HIL TRVNRKVATEF---ESFSLD-STFHAKKQIPCIVSMLTKELYFYH--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_gambiae_AGAP012945-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------E-DHKNSDCLLVVIMTHGDD-------DV-LHAKDG-TFNVDRLWE NFIGDSCPSLLGKPKLFFIQ--ACR----GSSF-DTGV----HF------SQ-CMT---- -QVA----------------K-T--------------------SSI-QYAIPSMADLLVM YSTYK--GHYSWRNPSTGSWFIRALCDELREHG-------NSKELL-----------QLL TSVSRRVAYEF---QSNVPN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_mulatta_ENSMMUP00000015808 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MENTENSVDSKS------------------------------------------- ------------------------------------------------------------ ---------------IKSLE---PKIIHGSKSVDSGI--------------SLENSYKMD YPEMGLCIIINNKNFH-------KSTGMASRSGTDVDAAN-LRETFINLKYE-VRNKNDL TREEIVELMRNVSKE-DHSKRSSFVCVLLSHGEE-------GI-IFGTNG-PLDLKKITS FFRGDCCRSLTGKPKLFIIQ--ACR----GTEL-DCGI----ET-----DSG-VE----- ----------------------D--------------------DMA-CHKIPVEADFLYA YSTAP--GYYSWRNSKDGSWFIQSLCAMLKQYA-------DKLEFM-----------HIL TRVNRKVATEF---ESFSLD-ATFHAKKQIPCIVSMLTKELYFYH--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_rubripes_ENSTRUP00000031759 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------SMQMAGEPTEISDLG GEVEEGGQSEDDVDAKP------------------------------------------- ------------------------------------------------------------ ---DRKGRFLLFKS-KKNKDGQMREQDYCSESHYRIV--------------SPTFQYKMS HQRVGKCIIINNKNFD-------EKTGMNVRNGTDRDAGE-LFKCFKTLGFD-VFIYNDQ TCEKMERLLREASEE-DHSDSSCFACILLSHGEE-------GM-IYGTDG-AMPIKTMTS MFRGDMCKSLVGKPKLFFIQ--ACR----GSEF-DDGI----QT-----DSG-PPN-DTM ET--------------------D--------------------ANP-RHKIPVEADFLFA YSTVP--GYYSWRNPGRGSWFVQALCNVLSEFG-------KQLEIM-----------QIL TRVNYMVATSF---ESWSED-PRFSEKKQIPCVVSMLTKELYFKQC-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >B_taurus_ENSBTAP00000021099 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MENTENSVDSKS------------------------------------------- ------------------------------------------------------------ ---------------IKTSE---TKILHGSKSMDSGI--------------SLEESYKMD YPEMGLCIIINNKNFH-------ENTGMCRRSPTDDSVAQ-XRETFMNLKYE-VRIKNDL TCKEMLELMSNVSKE-DHSKRSSFICVLLSHGEE-------GI-IFGTNG-PVNLKKLAS FFRGDYCRSLTGKPKLFIIQ--ACR----GTEL-DCGI----ET-----DSG-AE----- ----------------------D--------------------DMA-CQKIPVEADFLYA YSTAP--GYFSWRNAKNGSWFIQALCEMLKKHA-------HRLELM-----------HIL TRVNRKVAIEY---ESFSTD-SAFHAKKQIPCIMSMLTKELYF----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >E_caballus_ENSECAP00000019797 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MENSKISVDSKS------------------------------------------- ------------------------------------------------------------ ---------------IKNSE---TKILHGSKSMDSGI--------------SLDSSYKMD YPEMGLCIIINNKNFH-------KSTGMASRSGTDVDAAN-LRETFTNLKYE-VRNKNDL TGEEIVALMRSVSKE-DHSKRSSFICVLLSHGEE-------GI-IFGTNG-PIDLKKLTC FFKGDCCRSLAGKPKLFIIQ--ACR----GTEL-DSGI----ET-----DSG-IE----- ----------------------D--------------------DMA-CQKIPVEADFLYA YSTAP--GYYSWRNSKDGSWFIQSLCAMLKLYA-------HKLELM-----------HIL TRVNRKVAMEF---ESYCLD-PTFHGKKQIPCIVSMLTKELYFYH--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >D_rerio_ENSDARP00000019984 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MDKEALTSENEVSGDDQENYGKGDVTDAKPDPKAMCRVDKEALTSEIEVL EEDQDSYGEEDVTDAKP------------------------------------------- ------------------------------------------------------------ ---DRKGRFRLFGN-FKKNDGKLQEKG-ESESHYRIV--------------SPTFQYKMS HQRVGKCIIINNKNFD-------EKTGMNVRNGTDRDAGE-LFKCFKSLGFD-VAVYNDQ TCRNMERLLKAVSEE-DHSDSSCFACILLSHGEE-------GM-IYGTDG-AMPIKTMTS LFKGDVCKSLVGKPKLFFIQ--ACR----GSEF-DDGV----QT-----DSG-PPN-DTI ET--------------------D--------------------ANP-RHKIPVEADFLFA YSTVP--GYYSWRNPGRGSWFVQALCNVLSEFG-------KQLEIM-----------QIL TRVNYMVATSF---ESWSED-PRFSEKKQIPCVVSMLTKELYFN---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_familiaris_ENSCAFP00000032189 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MGEQRNTSSKELAAAEATGQSGK ELEVSMENTENSVDAKS------------------------------------------- ------------------------------------------------------------ ---------------FKNAE---TVIV---KILKDKY--------------LTKLHYKMD YPEMGLCIIINNKNFH-------KSTGMAPRSGTDVDAAN-LRETFTNLKYE-VRNKNDL TCEEILELMNSVSKE-DHSKRSSFVCVLLSHGDE-------GI-IFGTNG-PVDLRKVTG FFRGDYCRSLTGKPKLFIIQ--ACR----GTEL-DCGI----ET-----DSG-IE----- ----------------------D--------------------DMA-CQKIPVEADFLYA YSTAP--GYYSWRNSKDGSWFIQSLCAMLKLYA-------HKLEFM-----------HIL TRVNRKVATEF---ESFSLD-SAFHGKKQIPCIVSMLTKELYLYH--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_gambiae_AGAP009832-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------QPLTKA FSAMFSRKQEDSSDTRG------------------------------------------- ------------------------------------------------------------ ------------------MPHGSPIASGSQTANGIIR--PAY----VIE--RYAAYYPMN HKRRGMALIFSHNKYNV------RNVSLPVREGSAIDCKR-LKETLELFRFD-VKVYPDF KLEEIKSVIGKVSSM-DHSDSDCFLVAILTHGED-------GGIVYAYDQ-PYELSLIWS FFTADNCPSLAGRPKIFVVQ--ACR----GNQL-DHGV----KV-----QK--------- ----------------------D--------------------GVA-RYSIPTHADFLFA YATIP--GFMAFRNTTEGSWFINELCKELQENG-------HRYDIN-----------TLL TFVTQKVAYDH---ESVSNM-PEYNMRKQTPCVVSMLTRLLLFNVV-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_guttata_ENSTGUP00000011206 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------KKKNGEEEQPKPSLSNQYRIV--------------TPTFQYNMD YKKVGKCIIINNKNFE-------DKTGMGTRNGTDKDAGD-LAKSFKNLGFE-VDIHHDR SRDDMEKLLKKAAEE-NHSDAACFACILLSHGEE-------GL-IYGTDG-PMAIKSLTA LFRGDKCKSLIGKPKLFFIQ--ACR----GSEF-DEGI----QT-----DSG-PAN-DTL ET--------------------D--------------------ANP-RYKIPVEADFLFA YSTVP--GYYSWRNPGRGSWFVQSLCSVLNEHG-------KQLEIM-----------QIL TRVNYVVATNF---ESQSDD-PRFSEKKQIPCVVSMLTKELYF----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_domestica_ENSMODP00000005560 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MEDTGTTVDAKS------------------------------------------- ------------------------------------------------------------ ---------------IKNSG---VKSLHSSKSVESGL---------------SSDSYKMD YPEMGLCVIINNTHFH-------NDTELSPRTGSDKDAAN-LIDIFRSLKYE-VRNKNNL TRDKMIELLRQVSEE-DHSQRSSFVCVILSHGEE-------GV-IFGTDD-SVELKELTY FFKGYKCKSLTGKPKLFIIQ--ACQ----GREF-DCGV----ET-----DSG-TD----- ----------------------E--------------------DVA-CHKIPVEADFLYA YSTVP--GYYSLRDPKDGSWFIQALCAVLKQHA-------HKLEIM-----------QIL TRVNRKVATEF---ESYSSK-ASLHAKKQMPCIMSMLTKELYFSH--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_anatinus_ENSOANP00000002508 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MADDQAPTM HQKECD--FEDEVDAKP------------------------------------------- ------------------------------------------------------------ ---ERLK-VAQLFS-KKKNEAESQSGG-PLPVRNRVV--------------SSSFIYNMK YENLGKCIIINNKNFA-------SKTGMSTRNGTDKDAGN-LQKCFRSLGFD-VSVFNDF SCNQMKEILQKASEE-NHENSACFACILLSHGEG-------DC-IYGTDD-FIPIKELTI LFRGDKCKSLLGKPKLFFIQ--SCR----GTEF-DDGI----QT-----DST-PVT-D-- -S--------------------D--------------------ANP-GCRIPVEADFLFA YSTVPVKGYYSWRNVDRGSWFVQALCSVLHEHG-------KELEIM-----------QLL TRVNHQVAINF---ESQASD-PRYCQKKQIPCLVSMLTKELYF----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >R_norvegicus_ENSRNOP00000014096 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MDNNETSVDSKS------------------------------------------- ------------------------------------------------------------ ---------------INNFE---TKTIHGSKSMDSGI--------------YLDSSYKMD YPEMGLCIIINNKNFH-------KSTGMSARNGTDVDAAN-LRETFMALKYE-VRNKNDL TREEIMELMDSVSKE-DHSKRSSFVCVILSHGDE-------GV-IFGTNG-PVDLKKLTS FFRGDYCRSLTGKPKLFIIQ--ACR----GTEL-DCGI----ET-----DSG-TD----- ----------------------D--------------------DMA-CQKIPVEADFLYA YSTAP--GYYSWRNSRDGSWFIQSLCAMLKLYA-------HKLEFM-----------HIL TRVNRKVATEF---ESFSLD-ATFHAKKQIPCIVSMLTKELYFYH--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_guttata_ENSTGUP00000004278 ------------------------------------------------------------ ------------------------------MSGSERRPPAGHVQLDSRPTL--------- ------------------------------------------------------------ ------------------------------------------------------------ -PTTDGNENITEVDALN------------------------------------------- ------------------------------------------------------------ ------------------------------I-RQSLD--P-------------AEEYKMN HQRRGLALIFNHERFY-------WHLRLQDRRGTWVDRNN-LKSILTELGFE-VRLFDDL KKEDVQQRIYEASTA-DHSNADCFVCVFLSHGED-------GH-IFAYDD-KIEIQTITD MFRGDKCQSLVGKPKIFIIQ--ACR----GDKH-DDAV-I--AH-----DSA-DGS--ES PGNETD--------------V-D--------------------AAG-VYTLPAGADFIMC YSVAQ--GYYSHRDTINGSWYIQDLCETLRKHG-------SSLEFA-----------ELL TVVNRKVSCRR---VGMCKD-INAIGKKQIPCFASMLTKKLYFHPK--SK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_aculeatus_ENSGACP00000023055 ------------------------------------------------------------ ------------------------------MSDTTGDGRGGRVASPNKAAT--------- ------------------------------------------------------------ ------------------------------------------------------------ -DRAACTENLTETDALI------------------------------------------- ------------------------------------------------------------ --------------------------------RSSLD--P-------------AEEYKMD NKRRGLALIFNQERFF-------WRLGLNDRHGTNADRYN-LERRLSNLNFD-VRAYDNL KQEEVLNKINEAAEE-NHSDSDCFLLVFLSHGEN-------DQ-VYTYDG-KISVQDITS LFKGDKCKSLVGKPKIFILQ--ACR----GDKH-DDPV-T--AC-----DAV-DSE---L KTNEVV--------------V-D--------------------ASV-LHTLPAGADFIMC YSVAE--GYYSHRETINGSWYIQDLCELLQRYG-------DSHEFT-----------EVL TLVNRKVSMRS---VGNSSD-RSAIGKKQVPCFASMLTKKLYFRPK--Q----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >D_rerio_ENSDARP00000071815 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -MSDVKPKGVDTVDARQ------------------------------------------- ------------------------------------------------------------ ------------SDAKESSSVTDPGLVQMDAKSHSDD--------------NVDYQYKTN YPNLGQCLIINNKNFH-------KRTGMGVRNGTDEDAKK-VFETFSQLGFK-VGHYNDL TVSQMMALLNKASQE-DHSKSAMFACVLLSHGDD-------GL-IYGTDN-SIELKRLFA HFRGDRCTSLVGKPKLFFIQ--ACR----GTDL-DSGI----EC-----DGV-------- ----------------------G--------------------DEE-TQRIPVEADFLYA YSTAP--GYYAWRNVANGSWFISSLCDMLLKYG-------KQLEIM-----------QVM TRVNHKVALEF---ESSSNL-PGFDGKKQIPCIVSMLTKELYFPK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_carolinensis_ENSACAP00000012644 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------FR------------------------------------------- ------------------------------------------------------------ ------------------------------R-NHLFD--P-------------AAEYKMS HKRRGLALIFNHEHFF-------WHLMLPERRGTQADKEN-LKRGLTDLGFE-VKCFDDL KAEEVLQNIYNVSTD-EHDDADCFLCVFLSHGED-------DH-VYAYDA-KIEIKSLTN MFKGDKCPSLVGKPKIFVIQ--ACR----GDKH-DDPV-I--AR-----DTV-DSK-KEL DINETE--------------V-D--------------------TAA-VYTLPAGADFLMC YSVAE--GYYSHRETINGSWYIQDLCEMLKRHG-------SSLEFT-----------DLL TLVNRKVSHRE---VDVCKD-RKALGKKQIPCFASMLTKKLYFRPK--FK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_gallus_ENSGALP00000019870 ------------------------------------------------------------ ------------------------------MSGAERRPAAGRVQLDSKPTP--------- ------------------------------------------------------------ ------------------------------------------------------------ TTTADGNQNITEVDAFD------------------------------------------- ------------------------------------------------------------ ------------------------------K-RQTFD--P-------------AVQYKMN HQRRGVALIFNHEHFF-------WHLRLPDRRGTLADRNN-LKRSLTDLGFE-VRIFDDL KAEDVLKKVFEASRD-DYSNADCFVCVFLSHGEN-------DH-VYAYDA-QIKIETITN MFRGDKCQSLVGKPKIFIIQ--ACR----GDKH-DDPV-L--VQ-----DSV-DSK-DET TVNQTE--------------V-D--------------------AAG-VYTLPAGADFIMC YSVAQ--GYFSHRETVNGSWYIQDLCEALGKHG-------SSLEFT-----------ELL TVVNRKVSHRK---VDICRD-INAIGKKQIPCFASMLTKKLYFHPK--SK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_gambiae_AGAP012544-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MDATIINNNHSSLEA--------------------------------------------- ------------------------------------------------------------ ---------------------------------------MDS----TLQ--LTLHSYNMA HPKRGIAVVINNN---------------RDRKGSEKDVKA-LQAVLSHLQFD-VRLLSDK TTVEIRHALKEVSKE-DHTNNDCLAIIAMAHGYN-------DR-IKFDDD-YLHIDELWT NFVGNKCPSLIGKPKLVFIQ--SCR----GGKL-DYGASI-ATA-----DAR-PGL---- ----------------------E--------------------EPV-DVKIPMYADLLVM YSSFE--HHSSIRCRNEGSWFIQSFCQVLGANI-------AKTELQ-----------ALL CHVSYLVSIRS---DQTID--PEGKVVKQIPMVTSMLTKAFYFVPK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_nigroviridis_ENSTNIP00000009934 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MSANGPASGEDFTDASK------------------------------------------- ------------------------------------------------------------ -------------GGEQPSGSSSS---GKMTVDAKSA--------------RYSFRYSLD FPNLGHCIIINNKNFD-------RRTGMNTRNGTDVDAAN-AMKVFSNLGYR-VRVHNDQ TVAQISQLLTSAAKE-DHSRCASFVCILLSHGDE-------GV-LYGTDG-PMEIKSLTS LFRGDRCRSLVGKPKLFFIQ--ACR----GNDL-DGGI----ET-----DSI-------- ----------------------E--------------------DNS-TTKIPVEADFLYA FSTAP--GYYSWRNTMSGSWFMQSLCDTISKYG-------KELELQ-----------HIL TRVNHKVAVEF---ESDSSL-PGFNAKKQIPCIVSMLTKEMYFS---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_latipes_ENSORLP00000010095 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --MASNRPGEDSTDARK------------------------------------------- ------------------------------------------------------------ --------------DNGELAAGASPAPDRMDVDGKPS--------------SHSFRYSLN FPTIGLCIIINNKNFD-------RGTGMNQRNGTDIDAAS-AMKVFSKLGYR-VKIYNDQ TVKQIKQLLTDVSRM-DHSDSASFVCILLSHGDE-------GV-FFGTDG-SIELKTLTS LFRGDHCKSLVGKPKLFFIQ--ACR----GTEL-DDGI----EA-----DS--------- -------------------------------------------KED-TTKIPVEADFLYA FSTAP--GYYSWRNTMTGSWFINSLCEMLSKYG-------KELELL-----------HIM TRVNHMVAVEF---ESISTL-PGFHAKKQIPCIVSMLTKEMYFYP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_intestinalis_ENSCINP00000003204 ------------------------------------------------------------ ----------------------------------MSLKSAADVLMSGVPTP--------- ------------------------------------------------------------ ------------------------------------------------------------ HTNENNNVGQSEVDALG------------------------------------------- ------------------------------------------------------------ -------------------------SGETPRIYSLPD--VTK----MAS--SEVECYQMD RESRGLALIINNENFH-------HATRMNKRSGTDVDARN-LSRIFKKLGFD-VQVYKDL SCISMLEVINEVSTM-DHTGNDCCFVAFLSHGDD-------GC-VYGTDG-IVQIKKIVD QFRGDVCPSLAGKPKIFLFQ--ACR----GTLH-ETSVQL--SV-----DVV-DGEDQPC VEV-------------------D--------------------AAP-VPTLPSGSDYLFC YSVAE--GYYSHRDTLYGSWFIQDFTDVMEQLVLNKGKQQDKVDFI-----------DVL TVVNRKVSARR---VERSYS-QQALGKKQMPCYLSMLTKKLYLTPK--K----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >D_rerio_ENSDARP00000093958 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MK HAKRGLALIFNQKDFS-------L-LGLKTRKGTDKDRDS-LVSRFEELDFE-VKAYNDY SRDKVLKEIKEVAAA-DHVDADCFVCIFLSHGED-------GH-VYANDE-KIKIPEITD LFKGDKCRGLVGKPKIFIWQNKACR----GDKK-DDPV-A--PM-----SAE-DSD---- --DEMA--------------V-D--------------------AGV-SNTLPAGADFIMC YSTTE--GFCSFRDPLNGTWYIQDLCEIMGRYR-------SQLEFT-----------NIL TLVNRKVSLRS---I--CDD-LSATGTKQMPCFASMLTKRLFFRPK--K----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_aegypti_AAEL014348-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MKKIMFGRKEVNSPQQMIPTVA--PAY----TIE--RYSAYYPMN HKHRGKAIIFAHSVFAV------KNVNLPNRDGSDVDCEM-LVESLKRLHFD-VTLYKDY RLKDILLVIEKVSLM-DHSNSDCLLVAVLSHGDE-------GEVIYAHDC-PYQISSIWT QFTGDRCRTLVGKPKIFIIQ--ACR----GNDL-DSGV----KV-----EK--------- ----------------------D--------------------GVA-RYSIPTNADFLFA FATIP--GYMSFRNTKNGSWFIRELCNELNENG-------QRYDML-----------TLL TFVVQKVAYGY---ESYAPVHPDHHMKKQTPCVVSMLTRLLLFNNV-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_anatinus_ENSOANP00000005811 ------------------------------------------------------------ ------------------------------PRGATRLARGHP------------------ ------------------------------------------------------------ ------------------------------------------------------------ --AAGGAPNVTEVDGFY------------------------------------------- ------------------------------------------------------------ ------------------------------D-RETFD--P-------------AAKYKME YKRRGVALIFNHERFY-------WQLKLPDRHGTRADREN-LIRRLSALGFE-VKCFDDL KAEEVMLKIHQASSS-NHADADCFLCVFLSHGQG-------NH-VYAYNG-KIDIPEMTS MFKGDQCRSLVGKPKIFIFQ--ACR----GEQH-DVGV-V--PL-----DVV-DSKISEQ DVNETE--------------V-D--------------------AAS-VYTLPAGADFLMC YSVAE--GYYSHRETVNGSWYIQDLCEMLGRYG-------SSLEFT-----------ELL TLVNRKVSYRR---VDFCKD-PSLIGKKQVPCFASMLTKKLHFLPK--AQ---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_domestica_ENSMODP00000007353 ------------------------------------------------------------ ---------------------------------KSFGLFFVF------------------ ------------------------------------------------------------ ------------------------------------------------------------ --EGDAEQNATEIDAFF------------------------------------------- ------------------------------------------------------------ ------------------------------K-SKPLD--P-------------AEQYKMD HKRRGVALIFNHERFF-------WHLTLPERRGTRADRDN-LRQRLSDLGFE-VNCFDDL KAEDLLMTIHMVSTS-SHIDADCFLCVFLTHGEG-------NH-IYAYDA-KIDIQKLTA MFKGDKCQTLVGKPKIFVIQ--ACR----GDQH-DIPV-I--PL-----DVV-DHLSDKV DVNETE--------------V-D--------------------AAS-VYTLPAGADFLMC YSVAE--GYYSHRETVHGSWYIQDLCEMLEKYG-------SSLEFT-----------ELL TLVNRKVSQRR---VDFCKD-PNAIGKKQVPCFASMLTKKLYLFPK--PK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_intestinalis_ENSCINP00000011493 ------------------------------------------------------MDPHPA DFPEPPPQPRITLRSDTVDSSVFHDDDNLF--SMDDAVEQPDSFDAVPPNSYPSPNSSLS TSYSGGDILSMASPPLPVTRITERTQTAGEVIRTYNPSPE-------------------- ---------------------KRDHEVSYDELLEEDMKFSAEGVSDSVKHFYGAAIPVTC DDRVDTGAGYDTVDAGA------------------------------------------- ------------------------------------------------------------ ----------DYGSDAGPDNSDTGPPLPYKQKSKVIE--PEA----IAV--NREFQYPMN HKQRGCCIIFNQKHFD-------AHLRMDTREGTNHDAEN-IKHSMEMLGFEHVRIIKDS TKVEIINWIAAVSKA-DHSNYDCFACVILTHGGD-------KDVLYARDD-KMELKDFMQ PFRGDNCPSLATKPKLFFIQ--ACR----GFKL-AEPVKV--RP--VQCDSL-NYDTTDG GSA-------------------T--------------------VDE-FATIPAEADFLIA QSTVP--KYYSWRNKSNGSIFIQALCLTFNLFG-------EKQEIM-----------QMM TKVNRMVAYDY---ESASKD-PKMNQKKQIPSITTQLTAELYFPKK--REGHPSASEYSV NQQVTSPRQLQHNQVTARCEYDQYSSHTVRASDNAFVETTTQFSRLAMQAGDASRLEEAY MDPRTQGAAANPPSHASVRQRDLFPRPPPLPTKQRQTRRSNDSSHRRSGDYTTRRPPQEV YSSPTGSPRDVTPHYVTGYDAPPRRSSHETSPYGSQHNVARRRPSYETSFPAGSRAIPAV TLRKQSLPVSSMYSSSADSHLLTPNRHLHPSETVPARLSVSPNAARNSVNRRSLPLGTDP KPQAVSSWGSGINRAGLRSTKQTEV >D_rerio_ENSDARP00000006831 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------MNGDCVDAKR------------------------------------------- ------------------------------------------------------------ ----------VDTTDASKDGASAS---QPMQVDAKPQ--------------SHAFRYSLN YPNIGHCIIINNKNFD-------RRTGMNPRNGTDVDAGN-VMNVFRKLGYI-VKVYNDQ TVAQIMQVLTTVAHD-DHSRCASLVCVLLSHGDE-------GV-FFGTDT-SVDLKSLTS LFRGDRCPSLVGKPKLFFIQ--ACR----GTEL-DPGV----ET-----DHP-DHPDI-- -------------------------------------------PDG-RVRIPVEADFLYA YSTVP--GYYSWRNTMTGSWFIQSLCEMMTKYG-------SELELL-----------QIM TRVNHKVALDF---ESTSNM-PGFDAKKQIPCIVSMLTKEMYFTP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >D_rerio_ENSDARP00000041413 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MALIFNQKQFD-------WKLGLKTRNGTDKDRDDLVSRRFQELNFE-VKAYNDY SRDDVLLKIQEASAA-DHVDADCFVCIFLSHGED-------GH-VYANDK-KIEIPEITD LFKGDKCRSLVGKPKIFIWQKQACR----GDKL-DDAV-T--EM-----SVE-DVE---- ----MA--------------V-D--------------------AGV-LYTLPAGADFIMC YSTAE--GFCSFREPLNGSWYIQDLCEILGRYH-------SELQFT-----------DIL TLVNMKVSLRS---VPNCRN-RAAIGKKQMPCFASMLTKRLFFRDN--TQIQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_musculus_ENSMUSP00000029626 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MTETDGFY------------------------------------------- ------------------------------------------------------------ ------------------------------KSREVFD--P-------------AEQYKMD HKRRGVALIFNHERFF-------WHLTLPERRGTNADRDN-LTRRFSDLGFE-VKCFNDL RAEELLLKIHEVSTS-SHIDADCFICVFLSHGEG-------NH-VYAYDA-KIEIQTLTG LFKGDKCQSLVGKPKIFIIQ--ACR----GSQH-DVPV-V--PL-----DMV-DHQTDKL -DNVTQ--------------V-D--------------------AAS-VYTLPAGADFLMC YSVAE--GYYSHRETVNGSWYIQDLCEMLARYG-------SSLEFT-----------ELL TLVNRKVSQRR---VDFCKD-PDAIGKKQVPCFASMLTKKLHFCPK--PSK--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >X_tropicalis_ENSXETP00000052017 ------------------------------------------------------------ ----------------------------MASAKQQSSPSAGQIEKDSSSAS--------- ------------------------------------------------------------ ------------------------------------------------------------ -QNKEQKANVAETDGWT------------------------------------------- ------------------------------------------------------------ ------------------------------SRTLELD--P-------------SAEYKMT HKRRGLALIFNHEDFY-------WQLRLGSRRGTNTDSMN-LNRILTDLGFD-VQNYYNL RTLDILEKIQEASTA-DHSNADCFLCVFLSHGED-------RH-IYSYDS-LIDIQELTN SFKGDKCESLVGKPKIFIFQ--ACR----GEKH-DNPV-L--PT-----DET-DSV---T LTNITE--------------V-D--------------------AAS-LYTLPAGADFIMC YSVAE--GYYSHRETVNGSWYIQDLCEVLKAHA-------ASLEFT-----------EIL TLVNRKVSQRS---VAFCND-PKAIGKKQIPCFSSMLTKKLFLKPK--SN---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >R_norvegicus_ENSRNOP00000013049 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MTETDGFY------------------------------------------- ------------------------------------------------------------ ------------------------------RSREVLD--P-------------AEQYKMD HKRRGTALIFNHERFF-------WHLALPERRGTNADRDN-LTRRFSELGFE-VKCFNDL RAEELLLKIHEVSTS-SHVDADCFLCVFLSHGEG-------NH-IYAYDA-KIEIQTLTG LFKGDKCQSLVGKPKIFIIQ--ACR----GSQH-DVPV-V--PL-----DVV-DHQTDKL DDNVTQ--------------V-D--------------------AAS-VYTLPAGADFLMC YSVAE--GYYSHRETVNGSWYIQDLCEMLARHG-------SSLEFT-----------ELL TLVNRKVSQRR---VDFCKD-PGAIGKKQVPCFASMLTKKLHFCPK--PSK--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >D_rerio_ENSDARP00000050929 ------------------------------------------------------------ ------------------------------MASHTKSDGSAAVEKDSASAG--------- ------------------------------------------------------------ ------------------------------------------------------------ ---QTVEENLTETDSFN------------------------------------------- ------------------------------------------------------------ ------------------------------QSIFSMD--P-------------NQEYDMN HKRRGMALIFNHENFF-------WKLGLGYRSGTNADKEN-LIRRFRELNFE-VKAFDDY KRHEVLSKITEAAAA-DHVDADCFVCVFLSHGEN-------GH-VYANDG-QIEIPEITD LFKGDKCRSLVGKPKIFIWQ--ACR----GDKH-DDPV-T--PM-----DVV-DSQ---- VTNDMV--------------V-D--------------------AGV-LYTLPAGADFIMC YSVAE--GYYSHRETVNGSWYIQDLCEILRRYG-------SELEFA-----------EIL TLVNRKVSLRS---VLNCKD-RSAVGKKQVPCFASMLTKKLFFRPK--K----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_rubripes_ENSTRUP00000022652 ------------------------------------------------------------ ----------------------------------------GSDAELGKTAT--------- ------------------------------------------------------------ ------------------------------------------------------------ -DSSACTGDLMETDAIS------------------------------------------- ------------------------------------------------------------ ------------------------------GSIGFLD--P-------------AEEYKMD NKRRGLALIFNQERFF-------WRLGLRDRHGTNADSYN-LQRRLKELNFE-VKVFDNH TQAQVLEIITSAAKD-DHSNVDCFLVVFLSHGEN-------DH-IYTFDD-KINVQDITS LFKGDKCKSLVGKPKIFILQ--ACR----GDKH-DEPA-TAAAF-----DDV-DSE---L KKNEVE--------------V-D--------------------ASA-VYTLPAGADFIMC YSVAE--GYYSHRETVNGSWYIQDLCDLLRKYG-------DSLEFT-----------ELL TLVNRKVSMRS---VGYCSD-PNAIGKKQVPCFASMLTKKLYFRPK--K----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >H_sapiens_ENSP00000265164 ------------------------------------------------------------ -------------------------------MSSASGLRRGH------------------ ------------------------------------------------------------ ------------------------------------------------------------ --PAGGEENMTETDAFY------------------------------------------- ------------------------------------------------------------ ------------------------------K-REMFD--P-------------AEKYKMD HRRRGIALIFNHERFF-------WHLTLPERRGTCADRDN-LTRRFSDLGFE-VKCFNDL KAEELLLKIHEVSTV-SHADADCFVCVFLSHGEG-------NH-IYAYDA-KIEIQTLTG LFKGDKCHSLVGKPKIFIIQ--ACR----GNQH-DVPV-I--PL-----DVV-DNQTEKL DTNITE--------------V-D--------------------AAS-VYTLPAGADFLMC YSVAE--GYYSHRETVNGSWYIQDLCEMLGKYG-------SSLEFT-----------ELL TLVNRKVSQRR---VDFCKD-PSAIGKKQVPCFASMLTKKLHFFPK--SN---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_rubripes_ENSTRUP00000040691 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TN MSANGPSPGGDFTDAKK------------------------------------------- ------------------------------------------------------------ ------------GAGQQPRSGSSS---GRVTVDAKPA--------------AYSFRYSLD FPNMGHCIIINNKNFD-------RRTGMNTRNGTDVDAAN-AMKVFLSLGYK-VKVHNDQ TVNQMKQLLVSAAEE-DHSACASFVCVLLSHGDE-------GV-FFGTDG-SVELKYLTS LFRGDRCKSLVGKPKLFFIQ--ACR----GNDL-DGGI----ET-----DSA-------- ----------------------A--------------------DSS-TTKIPVEADFLYA FSTAP--GYYSWRNTTSGSWFMQSLCDAISKYG-------KELELQ-----------HIL TRVNHKVAVDF---ESVSNL-PGFDAKKQIPCIVSMLTKEMYFS---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_pygmaeus_ENSPPYP00000016744 ------------------------------------------------------------ -------------------------------MSSVSGLRRGH------------------ ------------------------------------------------------------ ------------------------------------------------------------ --PAGGEENMTETDAFY------------------------------------------- ------------------------------------------------------------ ------------------------------K-REMFD--P-------------AEKYKMD HRRRGIALIFNHERFF-------WHLTLPERRGTCADRDN-LTRRFSDLGFE-VKCFNDL KAEELLLKIHEVSTV-SHADADCFVCVFLSHGEG-------NH-IYAYDA-KIEIQTLTG LFKGDKCHSLVGKPKIFIIQ--ACR----GNQH-DVPV-I--PL-----DVV-DNQTDKL DTNITE--------------V-D--------------------AAS-VYTLPAGADFLMC YSVAE--GYYSHRETVNGSWYIQDLCEMLGKYG-------SSLEFT-----------ELL TLVNRKVSQRR---VDFCKD-PSAIGKKQVPCFASMLTKKLHFFPK--SN---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_gambiae_AGAP004922-PA ------------------------------------------------------------ ---------------------------------------------CNLMDD--------- ------------------------------------------------------------ ------------------------------------------------------------ LPPEPTPNNEFYDGNIPE------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MLMTHGDD-------DV-LYAYDG-PYSVDKLWE SFMGNACTTLLGKPKLFFVQ--ACR----GSTF-DKGV----KL------GC-RDL---- -DSD----------------H-F--------------------SSH-KYVIPTTADLLVM YSSYK--GHVSWRSPRGGSWFIQALCVELETNW-------KHMELL-----------QLL TGVSRRVAYDY---QSNVPCKGRMDAMKQMPSIVSMLTKLVYFPLK-------------- -------------------------------------L---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GS----- >E_caballus_ENSECAP00000013268 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----GEEQNMTEIDAFY------------------------------------------- ------------------------------------------------------------ ------------------------------K-REMFD--P-------------AEKYKMD HKRRGIALIFNHERFF-------WHLTLPDRRGTSADRDN-LMRRFSDLGFE-VKCFNDL KAEELLLKIYEVSTS-SHADADCFVCVFLSHGEG-------NH-IYAYDA-KIEIQTLTG LFKGDKCQSLVGKPKIFIIQ--ACR----GDQH-DVPV-T--PL-----DVV-DHGTDKL DANVTQ--------------V-D--------------------AAS-VYTLPAGADFLMC YSVAE--GYYSHRETINGSWYIQDLCEMLARFG-------SSLEFT-----------ELL TLVNRKVSQRR---VDFCKD-PSAIGKKQVPCFASMLTKKLHFFPK--SK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_aculeatus_ENSGACP00000022402 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --MSVNGPGEDRTDAKT------------------------------------------- ------------------------------------------------------------ --------------EQSEVSSSAS---APEEVDAKPN--------------VHSFRYSLS FPSIGQCIIINNKNFD-------RGTGMNQRNGTDVDAAN-AMKVFGNLGYK-VKVYNDQ SVAQIQHVLTSVSKQ-DHSCSASFVCVLLSHGDG-------DL-FFGTDG-PVPLKSLTS LYRGDRCKSLVGKPKLFFIQ--ACR----GTEL-DPGI----EA-----DSV-------- -------------------------------------------KDE-TTRIPVEADFLYA FSTAP--GYYSWRNTTTGSWFMQSLCDMISKYG-------KELELQ-----------HIM VRVNHKVAVAF---ESVSNS-PDFNARKQIPCVVSMLTKEMYFSP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >D_rerio_ENSDARP00000072390 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------AFEPYKK HKNIGKCLIISNEHFP-------VQFSLNRKKGNSVDERR-LSSTFKSLGFH-VKVENNL SANQMIDALRTVSEE-DHTDNSCFVCVLMSHGEE-------GT-ILGSDERWIPVKTLTS LLTSDLCPSLRDKPKIFFLQ--ACR----GVEY-DPGV----EA-----DSV-EAS---- --------------------E-D--------------------FFG-ISDVP-ELDFLCC YSTVE--GYFAWRNPETGSIFIRELCKTLMD---------CRLEII-----------QIL TRVNHLVAYYF---QSYTLE-LETNRKRQMPCFASRLTKDFYLHV--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DKYRYKMD YPCMGTCVIINNKTFD-------PKTGLSPRNGTDVDAAE-LEKTFSRLGYK-VTVANDQ TADQMVDLLADVSKQ-DHRKSASFVCALLSHGDE-------DG-IYGTDG--TSLDDLTK FFKGDRCRSLVGKPKLFFIQ--ACR----GTDT-DRGV----NF-----DAD-ST----- ----------------------D--------------------GQM-LQSIPLEADFLYA YSTPS--GYYSWRNTQNGSCFMQSLCEILHSFS--------QLELM-----------QIM TRVNYEVALHF---ESSSDK-LGYSGKKQIPCIMSMLTKDFYFPK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >B_taurus_ENSBTAP00000016642 ------------------------------------------------------------ -------------------------------MSSEPPPRRAR------------------ ------------------------------------------------------------ ------------------------------------------------------------ --GPGEEQNMTEIDAFP------------------------------------------- ------------------------------------------------------------ ------------------------------R-REIFD--P-------------TEKYKMD HKRRGIALIFNHERFF-------WHLTLPNRPGTSADRDN-LRRRFSDLGFE-VKCFDDL RAEELLLKIHEASTA-SHVDADCFLCVFLSHGEG-------NH-IYAYDA-KIEIQTLTG LFKGDKCQSLVGKPKIFIIQ--ACR----GSQH-DVPV-I--PL-----DVV-DHRTDTP DANLTQ--------------V-D--------------------AAS-VYTLPAGADFLMC YSVAE--GYYSHRETVNGSWYIQDLCEMLGKFG-------SSLEFT-----------ELL TLVNRKVSQRR---VDFCRD-PNAIGKKQVPCFASMLTKKLHFSPK--SK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_nigroviridis_ENSTNIP00000021186 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RMETDAFY------------------------------------------- ------------------------------------------------------------ ------------------------------GRNSIVD--P-------------AEEYKMD NKRRGLAIIFNQESFF-------WRLGLKDRHGTNADSYN-LQRRLRELNFD-VNVYNNY KQQEVLDIINAAAKA-DHSDVDCFLLVFLSHGEN-------DH-IYANDD-KISIQDITS LFKGDKCKSLVGKPKIFIWQ--ACR----GDKH-DEPA-TAAAF-----DDV-DSE---S KKNEVE--------------V-D--------------------ASA-VHTLPAGADFIMC YSVAE--GYYSHRETVNGSWYIQDLCDLLLRYG-------DSLEFT-----------ELL TLVNRKVSMRS---VGYCRD-PNAIGKKQVPCFASMLTKKLYFRPK--KKSK-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_troglodytes_ENSPTRP00000028104 ------------------------------------------------------------ -------------------------------MSSASGLRRGH------------------ ------------------------------------------------------------ ------------------------------------------------------------ --PAGGEENMTETDAFY------------------------------------------- ------------------------------------------------------------ ------------------------------K-REMFD--P-------------AEKYKMD HRRRGIALIFNHERFF-------WHLTLPERRGTCADRDN-LTRRFSDLGFE-VKCFNDL KAEELLLKIHEASTV-SHADADCFVCVFLSHGEG-------NH-IYAYDA-KIEIQTLTG LFKGDKCHSLVGKPKIFIIQ--ACR----GNQH-DVPV-I--PL-----DVV-DNQTEKL DTNITE--------------V-D--------------------AAS-VYTLPAGADFLMC YSVAE--GYYSHRETVNGSWYIQDLCEMLGKYG-------SSLEFT-----------ELL TLVNRKVSQRR---VDFCKD-PSAIGKKQVPCFASMLTKKLHFFPK--SN---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_aegypti_AAEL012143-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MM-DHSEHDCVSITILSHGEL-------GY-LYAKDC-QYKLDIIWS YFTANRCPTLAGKPKVFFIQ--ACQ----GDQL-DAGV----TL-------A-ERTET-- --------------------DSA--------------------GSM-SYKIPAHADFLIA YSTIP--GFYSWRNTQKGSWFMQSLCQELTQHG-------KKYDLL-----------TLL TFVAQRVAYDF---ESNTPDIPMMHQQKQIPCVTTMLTRLLRFTEK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_latipes_ENSORLP00000010793 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MDM AETAEELSGKDQVDTKP------------------------------------------- ------------------------------------------------------------ -------------VISKRSPANQPNPRSTDVCVIKQD--------------ADPYRYSMD YPKMGICLIINNKNFH-------KDSGMGPRNGTDNDAAA-AWKSFMKLGYE-IQMYNDQ TVDQMKKLFRQMSNQ-DHSKFASFACVILSHGEE-------GV-IYGTDG-PVSFNKLIE CLKGRSCLSLVGKPKLFFIQ--ACR----GTLF-DEGI----EH-----DAK-------- -------------------------------------------DDT-SEKIPLEADFLFA YSTVS--GYYSWRSTANGSWFIQSLCEMLEKFS-------KTLDLM-----------QIM TRVNHKVATHF---ESSSNA-PGFSGKKQIPCIVSMLTKDFYFPYESN------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MSPRNGTDVDAAD-AFRTFSKLGYK-VTVANDQ TVDQMIQLLVKVSKQ-DHSNSASFVCVLLSHGDE-------GV-IYGTDG-FEKLDDLTK FFKGDRCRSLVGKPKLFFIQ--ACR----GTEL-DEGS----QI-----EAD-SV----- ----------------------G--------------------GQT-SDRIPVEADFLYA YSTAP--GYYAWRNTQNGSWFMQSLCEMLRRFS-------GQLELM-----------QIM TRLNHRVALHF---ESSSDT-PGYSGKKQIPCIVSMLTKDFYFPK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_anatinus_ENSOANP00000005531 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------YRMN RAHRGYCIIFNNYTFKG---------KLNSRKGTQKDVAE-LERVFRWLGLD-VETFNDK SRQEMVATLEECSRRPDHDVRDCLVCCVLSHGES-------GA-VYSADEELIPIRQIMS YFTAKDCPSLAHKPKLFFIQ--ACQ----GKDI-QEAVQI--EP-----DAR-NPDLDPQ PEPPPA--------------P-R--------------------ESP-KDSIPAEVDFLLG MATVD--GYASFRHVNQGTWYIQALCRQLALLVP------RREDIL-----------SIL TAVNDDVSQRA---D-------HLGKKKQMPQPAFTLRRKLVFP---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_familiaris_ENSCAFP00000016791 ------------------------------------------------------------ -------------------------------SSATCGLRRAY------------------ ------------------------------------------------------------ ------------------------------------------------------------ --RTADEQNVTETDAFY------------------------------------------- ------------------------------------------------------------ ------------------------------K-REMFD--P-------------EEKYKMD HKRRGIALIFNHERFF-------WHLTLPDRRGTSADRDN-LVRRFSELGFE-VKCFNDL KAEELLLKIHEASTS-SHIDADCFLCVFLSHGEG-------NH-IYAYDA-KIEIQTLTG LFKGDKCQSLVGKPKIFIIQ--ACR----GDQH-DVPV-L--PL-----DVV-DHRTDKL EDNVTE--------------V-D--------------------AAS-VYTLPAGADFLMC YSVAE--GYYSHRETVNGSWYIQDLCEMLGKFG-------SSLEFT-----------ELL TLVNRKVSQRR---VDFCKD-PNAIGKKQVPCFASMLTKKLHFFPK--SK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_gallus_ENSGALP00000013591 -----------------------------------------------------------M EFSQLLFVISEALDRTELASLKFLSLEHVTVRKREDIEEPKAFFQALQEKGMIEVGDLFF LKELLYRINRIDLLASYLGSSREEMERELQVPGRARVSPF-------------------- ------------R----YLLFQLSENITKDDMKCFKFLLG-KELPKCKLSPETTMPDVFI EMEKKGILKEDNLTVLKT-----ICGKVDKS-----LLKKIEDYE--------------- --LNLLGEGEMLVTEGQRSSTGAPEDSAIWLASSVAPDSLGNCDQS-------------- ---------------------------------------------------SQLEVYKMT SRPRGVCLILNNHNFAKAREAVPELRRMKDRNGTHVDADA-LRKVFSNLHFT-VAEYKDC TAEEIRNIVNNYRCM-DHNNKDCFVCCILSHGKK-------GI-IYGVDGQEVPIQELTT SFTGQNCQSLAGKPKVFFVQ--ACQ----GDAY-QKGVTI--ET-----DSG-EQDYS-- ---LET--------------D-A--------------------RFQ-LDCIPSEADFLLG MATLQ--DYVSYRSPSQGTWYIQSLCQHLESSCP------RGEDIL-----------TIL TAVNQEVSSKI---D-------KQNAGKQMPQPSFTLRKKLIFPVN-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_nigroviridis_ENSTNIP00000001216 ------------------------------------------------------------ --------------------------------------SAYQLFLSLCDQDHLSEERPHL LSELLSIIQRTRLL-RDLDLRSSATSNL--------ISAY-------------------- ------------R----KLLYSLSEDLTDDNLKEIKFLLT-ETLPRRKLEDNVTTLEVFL ELECMDLLSKTNLGLLKS-----ILQPVCPV-----LAERIRQFE------------AQN -------------------SCQPAADWGFAVKKITDPLQVQ--------GGSDALPSLPE ENQSSSRTEASVMSSANAVGIKPGTLMLGLS-PPPVG--SPN----FPV--QDLGTYPMT TLPRGCCLIISNYDFQGS--------GLGMRNGTRTDEEC-LKKVFEWLGFK-VEIHRDC TGKEILSLMQELADK-SQQRWDCLVCCILSHGLE-------GC-VHGVDGDQVSIKKLIE PFLGTNCPAMAGKPKLFFIQ--ACQ----GKKQ-QGVVHL--ES-----DGA-EHSDV-- ----DT--------------D-A--------------------VRL-SNCIPSHADFLLG MATVP--DYVSYRDRERGTWYIQSLCEYLVKMVP------RGFDLM-----------SIL TKVNEDVSKKN---D-------NTGDRKQMPQPVFTITKRIVFPVP-----SGPAPVLPH FPFVEDSP---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_familiaris_ENSCAFP00000017933 ------------------------------------------MTSQAQSLTFRSDDNCQS SFRGKLLTIDSKLEIQDVEGLKFLCRDFVSHKKLEKSNSASDIFDHLLAEELLSEEDPFF LAELLYIIKQNSLL-RYLNQSKEQVESLL--PTRRRVSLF-------------------- ------------R----NLLYELSESIGSENLKDMIFLQR-DSMPKTQLT----PLSFLA YLEKQALIDEDNLGLLED-----LCRKVVPN-----LIRKIERYK------------REK A--SEVVTPPVDTETESLHQKEEELFSPSDINQFHGALSKQTSWN--------------- -P-LKHRAKQGNIISDGA-TLVSVEMLEAST-GPLTS--ET------ST--KEANVYRMD RKHRGHCVIVNNHTFAK----------MPDRPGTDKDAEC-LSRVFQWLGFS-VHVYKNV TKGHLDEVLQEFKCHPDHVDGDCFVFCVLTHGKF-------GA-VYSSDGTLVPIREIMS HFTAQKCPGLAHKPKLFFIQ--ACQ----GKGI-QTPVSI--EA-----DAV-NPEHV-- ----------------------S--------------------PSL-KDSIPDAADFLLG LATVP--GYVSFRHVEKGSWYIQSLCNRLKSLVP------RHEDIL-----------SIL TAVNNDVSQQA---D-------KQGTMKQMPQPAYTLRKKLVFPVP-----QKEL----- ---LL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_mulatta_ENSMMUP00000037892 VEGGRRARVVTESKRNFFLGACPTPFPTEHVELGRLGGSETAMVPGKGGADYILLPFEEM DFNRNLYDIGEQLDSEELASLKFLSLDCIPQRKQEPIKDALMLFQRLQEKRMLEENNLSF LKELLFRINRLDLLTTYLNTRKEEMERELQAPGRAQISAY-------------------- ------------R----VMLYQISEEVGRSELRSFKFLLQ-EEISKCKLDDDMNLLDIFV EMEKRVILGEGKLDILKR-----VCAQVNKS-----LLKIINDYE------------EFS RERTRSLEGSPEEGSNG--------EELCGLMTISDSPREQDSESQ-------------- ---------------------------------------------------TLDKVYQMK SKPRGYCLIINNYDFTKAREKVPKLHSIRDRNGTHLDAEA-LTATFEELHFE-IQHHNDC TVEKIYKILKTYQLM-DHSNKDCFICCILSHGDK-------GI-IYGTDGQEAPIYELTS QFTGLKCPSLAGKPKVFFIQ--ACQ----GDNY-QKGIPV--ET-----DSE-E-QPY-- ---LEM--------------DLS--------------------SPQ-TRYIPDEADFLLG MATVN--NCVSYRNPAEGTWYIQSLCQSLRERCP------RGDDIL-----------TIL TEVNYEVSNKD---D-------KKNMGKQMPQPTFTLRKKLVFPSD-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_gallus_ENSGALP00000013506 -----------------------------------------LKSFKPHWISSNMEDDDSL QFRQLLLLIDEGLGAEDVAALKFLCTDLIPFRKLESVQSAMDIFQLLIDEDYLNEEDTFL LAELLYRIKYHSLL-SKLGYTKEKVQECL--HEKGKVSPY-------------------- ------------R----QMLYELSENITNDMLQEIVFLLR-NHLPKRRRT--ISALELLI LLEKQCLLTENNVQILEE-----VFRNVSPD-----LLETVKCYR------------MAK VALPHQGNTLPIKESSPSYTVHVRLFNSPQGGSFILVLNESYCES--------------- -LRNKKYSVTGASAACHAISMPSTGVQNALA-NTTVC--YS------SF--LQVSSYKMD GPRRGICLVINNVKFDG---------VLQERKGSYKDACE-LERVFTWLGLD-VRTYTDQ TSDQIKELMQAWQRSEDHKNRDCFVCCILSHGES-------GA-VYGKDGKLVSIRTIMT YFTAKQCPQLTEKPKLFFVQ--ACQ----GKEV-QRPVYV--ET-----DAR-VPDFSSV PQ--------------------S--------------------TSP-SESIPEEADFLLG MATID--GYASFRHVQEGTWYIQALCSKLQLLVPS-----RGEDIL-----------SIL TEVNEDVSKRV---D-------RYGTRKQMPQPAYTLRRKLIFPIP-----RDPP----- ---PS------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_intestinalis_ENSCINP00000025743 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------KYKMN HKERGCFMIFNQEVYDAK-----TSLNLGERIGSSTDARN-LASAAAYLGFEYIQVFNNL TRSKILKWLKDVAAA-SHESYDCFGCAILTHGDK-------NNELYARDA-SMNITDFTN PFTADKCPTLAGKPKLFFVQ--ACR----GHKR-DTAVPF--TL-----NVA-STI---- ----------------------E--------------------KTE-LKLIPCQADFLIA SSTPE--GYSSWRNKANGSWFIQALYLCIQRY--------PSLEIM-----------QIM TRVNRMVALHF---E--NTNTESPDIYKQIPSICTRLTGELYFHKP--GST--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_aculeatus_ENSGACP00000005791 -----------------------------------------------------------M HFQKLLFDIGKALSGEEVKALAFLCTDILG-RNLSSVESASGLFSRLRDQGFLSAEQPHL LTELLIIIQRVRLT-RDVDLPAEP---------SSLISPY-------------------- ------------R----KMLYNLSEELTADDLKDMKFLLH-SYLPRRKLEENVSTLEIWL EMEHKDLMNEHNLHLLEI-----LISKVCPM-----LKDKINQLKAQQETPTSPATQESG RQGSLSAPNAPNQVPQSL------GAEGTGLFEMQDSPSGFNGGG--------------- DCAALSLGLSGHLKIEVVETMPPPKNMSCSE-PPTSQ--PSD----TNT--EVLGTYPMT SAKRGICLIVNNFDFTK-------FKNYQNREGTMKDEER-LHKVFAWLGFE-VEVKHDC EGEQMLTALRELASR-NHGQADCLVCCVLSHGDE-------GC-VYGVDGHTVAIKELKE PFNGLNCASLAGKPKLFFIQ--ACQ----GTGE-QKAVNV--VP-----DGP-EDSAV-- ----CS--------------D-A--------------------FKA-SDAIPSEADFLLG MSTVP--SFVSYRHRKNGSWFIESLCQNLVQMVP------K----L-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_carolinensis_ENSACAP00000001629 ------------------------------------------------------------ -FRQILLAIDENLGKEDVDAMKFLCSDFISTKHLEGVETAQDIFQLLINRNLLSKEDTFI VAELLYRIKCHFLL-QKIGYTQQKVEHNL--FHIRNVSEY-------------------- ------------R----QMLYEISEGFTEENVKTAMFLLR-EHLPKKQSI----AVKLLT SLEKQDLLAEDKLAILEK-----ICNKVSPE-----LRNKVDKFK------------ERS VFKAFVFS-----------LCYENLYPSNFLAVFLLIL---------------------- ---------------------------------------------------QASTCYKMD GLNRGSCLIFNNVHFEG---------GLSQRRGSQKDAEE-LESVFRWLGLD-VIKYNDT TSIEMENHLKQWQSFENWKDMDCLVCCILSHGES-------GK-IYGTDGNLIPIRTIMS YFTAKQCPQLAKKPKLFFIQ--ACQ----GEKT-QQPVYL--ET-----DDE-YGSFP-- ----------------------L--------------------QQM-ISSIPEEADFLLG MATVD--GYLSFRHVHQGTWYIQALCDKLRTLVP------RGEDIL-----------SIL TEVNADVSRRA---D-------AQGQKKQMPQPAYTLRKKLIFPIP-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >D_rerio_ENSDARP00000075318 ------------------------------------------------------------ ---------MADQLLENLRPDLIKGLSERVINGLLDDLQQKKVFGEEEIEDIQHRMKTRA DQAR-------------------------------------------------------- -----------------------------------------HVIDDVKRKGVKASEIMLA SLKTRDPHLYDTLGIER------------------------------------------- ------------------------------------------------------------ -----------------LLVPVPETELTPSQLSETTG--CST----DKT--NTMNEYEMK SNPRGLCLIFNNENFKDP---------DMKRHGSQMDTAS-LKDLFEWLGFS-VEIKQDQ TVSAMKRTLKEYSE--DRKHGDCFVCCVLSHGNE-------SG-VLGSDEKICPVDDITS PFNGANCSSLAGKPKVFFIQ--ACR----GHEI-QSKVMV--AD-----GSG-GSRTQ-- --------------------K-P--------------------GRV-SVSIPKDSDFLIA RSTVE--GYVSIRDRTSGTWFIQSLCENLKEGSK------RGHDIL-----------MIL TKVNNDVSRKE---GSLKVK-NEIVDAKVTPQPIFTLRKLLIFRPL--KKTGRFS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_domestica_ENSMODP00000036247 -----------------------------------------------------------M DFHTFLYGIAEEIDSADLASLKFLCLDQIPLKKQQHIKDALVLFQTLEERGLLEEDNLFF LKELLFRINRIDLLNEPLNTKGPEMERELQVPNKARISPYRLHLHTTIWPFRDNWTCRIT LSVSFTSRTKQLLSVMVILLFNLSEGVGPSELKSIKFMLS-SKIPKCKIEDDMTLMDLFI EMEKRGILGEGNLDALKI-----VCDQIDKS-----LLKKIQEYE------------ISK GRNNL-----------------FLIYQNTQPQEVYDSAG--------------------- ---------------------------------------------------EKGNVYKMS SRPRGYCLIINNFDFKISRKERPENHYLTDRRGTNKDEEA-LKNIFKELHFD-IQSFQDL TAEGIQQVLKTFKDN-NHESKDCFVCCLLSHGNK-------GT-IYGIDGKEVPIRDLTS YFSGSNCPSLAGKPKVFFIQ--ACQ----GKAT-QYGISL--DT-----DSE-QQRES-- ---LEA--------------D-K--------------------SFQ-SECIPNEADFLLG MATVE--NYVSYRDSARGTWYIQSLCKNLKEGCL------RGNDIL-----------TIL TEVNSEVSQKT---D-------PKNNGKQMPQPKITLRKKLVFPIS-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_troglodytes_ENSPTRP00000021879 MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKM DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY-------------------- ------------R----VMLYQISEEVSRSELRSFKFLLQ-EEISKCKLDDDMNLLDIFI EMEKRVILGEGKLDILKR-----VCAQINRS-----LLKIINDYE------------EFS KERSSSLEGSPDEFSNG--------EELCGVMTISDSPREQDSESQ-------------- ---------------------------------------------------TLDKVYQMK SKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGA-LTTTFEELHFE-IKPHDDC TVQQIYEILKIYQLM-DHSNMDCFICCILSHGDK-------GI-IYGTDGQEAPIYELTS QFTGLKCPSLAGKPKVFFIQ--ACQ----GDNY-QKGIPV--ET-----DSE-E-QPY-- ---LEM--------------DLS--------------------SPQ-TRYIPDEADFLLG MATVN--NCVSYRNPAEGTWYIQSLCQSLRERCP------RGDDIL-----------TIL TEVNYEVSNKD---D-------KKNMGKQMPQPTFTLRKKLVFPSD-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_intestinalis_ENSCINP00000011503 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MERMSDETPRKPAAGDVLKIYKSE VKRNATSESDENIDAIS------------------------------------------- ------------------------------------------------------------ --------------------DSSDDFYKDDDDDGKGL--VPT----VLR--QHMLEYYMK NERRGTFVVFNQENFDR---------MRHPRKGSGVDVEM-LVKSANKLGFEDVRVLKNQ TTDEIRDHLQELSYQ-DHSNCDCFVCVVLSHGES-------DGVLYTKDG-DIHLKEILD SFKASRCPSLAGKPKLFFIQ--ACR----GEKR-STPVEI--EYKFDVTDST-PPE---- --------------------E-Q--------------------TTT-VFTIPAEADFLIA HATPE--EFCAWRNRREGSRFIKALCGCLDRYAG------DDIELL-----------QIL TVVNHHVSHGW---D---GEVYKYEKSKQIPSITTQLTAQLFFTKK--SKNKICQEKPQG TIKENENANAQANDDFIAHEGQETEKEISRPIPSPRHKKTET------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------QV------- >H_sapiens_ENSP00000351273 MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKM DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY-------------------- ------------R----VMLYQISEEVSRSELRSFKFLLQ-EEISKCKLDDDMNLLDIFI EMEKRVILGEGKLDILKR-----VCAQINKS-----LLKIINDYE------------EFS KERSSSLEGSPDEFSNG--------EELCGVMTISDSPREQDSESQ-------------- ---------------------------------------------------TLDKVYQMK SKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGA-LTTTFEELHFE-IKPHDDC TVEQIYEILKIYQLM-DHSNMDCFICCILSHGDK-------GI-IYGTDGQEAPIYELTS QFTGLKCPSLAGKPKVFFIQ--ACQ----GDNY-QKGIPV--ET-----DSE-E-QPY-- ---LEM--------------DLS--------------------SPQ-TRYIPDEADFLLG MATVN--NCVSYRNPAEGTWYIQSLCQSLRERCP------RGDDIL-----------TIL TEVNYEVSNKD---D-------KKNMGKQMPQPTFTLRKKLVFPSD-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >D_rerio_ENSDARP00000075645 ------------------------------------------------------------ ------------------------------MDKTSNPNNSNQINRASPNEQ--------- ------------------------------------------------------------ -----------------------------------------EKIKTDEPKRKNTSQEDKE NLHKGVQNNNSPKRQRE------------------------------------------- ------------------------------------------------------------ -----------------------PLQSTCNISDHYPK--RKR----AVT--EQKEWYSMS NRPLGYCLIINNYKFE--------SASLADRRGTDRDKDD-LTKVFEKMYFK-VEVRDDL QASDMRNVIKEFAEK-DHSQMNAFVCCILTHGEK-------GT-VLGTDGKQVPIRELSQ PFA--ECRSLASKPKLFFIQ--ACQ----GNMR-QQGLWM--AH-----ERE-NTTEEEA YEE-----------------DAH--------------------AAG-NYSIPMDADFLFA IATVE--HFRSYRHITNGSIFIQVLCKQLERGCA------QKKDIL-----------SIL TAVNGVVGSKI---L---------QGYKQMPEVRYTLTKALVLPMN--GVS--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_musculus_ENSMUSP00000027189 -----------------------------------------------------------M DFQSCLYAIAEELGSEDLAALKFLCLDYIPHKKQETIEDAQKLFLRLREKGMLEEGNLSF LKELLFHISRWDLLVNFLDCNREEMVRELRDPDNAQISPY-------------------- ------------R----VMLFKLSEEVSELELRSFKFLLN-NEIPKCKLEDDLSLLEIFV EMEKRTMLAENNLETLKS-----ICDQVNKS-----LLGKIEDYE------------RSS TERRMSLEGREEL------PPSVLDEMSLKMAELCDSPREQDSESR-------------- ---------------------------------------------------TSDKVYQMK NKPRGYCLIINNHDFSKAREDITQLRKMKDRKGTDCDKEA-LSKTFKELHFE-IVSYDDC TANEIHEILEGYQSA-DHKNKDCFICCILSHGDK-------GV-VYGTDGKEASIYDLTS YFTGSKCPSLSGKPKIFFIQ--ACQ----GSNF-QKGVPD--EA-----GFE-QQNHT-- ---LEV--------------D-S--------------------SSH-KNYIPDEADFLLG MATVK--NCVSYRDPVNGTWYIQSLCQSLRERCP------QGDDIL-----------SIL TGVNYDVSNKD---D-------RRNKGKQMPQPTFTLRKKLFFPP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >R_norvegicus_ENSRNOP00000016613 -----------------------------------------------------------M DFHSCLYDIAERLGNEELAALKFLCLDHIPQKKQESINDVLVLFQRLQEEGMLEEDNLSF LKELLFHISRRDLLSRVLKSSPEEMVRELQVLGKAQVSAY-------------------- ------------R----VMLFKLSEDMDKEDLKSFKFLLI-TEIPKCKLQDNSSLLDIFV EMEKRTILAENNLVTLKS-----ICFRVNRS-----LLGRIDDYE------------RSS TERRMSTEGGEEL------PVSVLDEVTIKMQDMWDSPGEQESESL-------------- ---------------------------------------------------NSDNVYQMK SKPRGYCLIFNNNNFSKAREDIPKLSNMRDRKGTNYDEEA-LSKTFKELHFE-IVSFSDC TASQIHEVLVSYQSK-DHKGKDCFICCILSHGDK-------GI-VYGTDGKEASIYELTS YFTGSKCPSLAGKPKIFFIQ--ACQ----GNNF-QKAVPVPDET-----GLE-Q-EHV-- ---LEE--------------D-S--------------------SSY-KNYIPDEADFLLG MATVK--NCVSYRDPTRGTWYIQSLCQSLRERCP------RGEDIL-----------SIL TGVNYDVSNKD---N-------PRNMGKQMPQPIFTLRKKLFFPPN-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_pygmaeus_ENSPPYP00000014606 -----------------------------------------------------------M DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQS VPFWWRVDHILIR----VMLYQISEEVSRSELRCFKFLLQ-EEISKCKLDDDMNLLDIFI EMEKRVILGKGKLDILKR-----VCAQINKS-----LLKIINDYE------------EFS RG-----------------------EELCGVMTISDSPREQDSESQ-------------- ---------------------------------------------------TLDKVYQMK SKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGA-LTTTFEELHFE-IKPHNDC TVEQIYEILKIYQLM-DHSNMDCFICCILSHGDK-------GI-IYGTDGQEAPIYELTS QFTGLKCPSLAGKPKVFFIQ--ACQ----GDNY-QKGIPV--ET-----DSE-G-QPY-- ---LEM--------------DLS--------------------SPQ-TRYIPDEADFLLG MATVN--NCVSYRNPAEGTWYIQSLCQSLKERCP------RGDDIL-----------TIL TEVNYEVSNKD---D-------KKNMGKQMPQPTFTLRKKLVFPSD-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >D_rerio_ENSDARP00000063081 ------------------------------------------------------------ --------MSKKESTQRILQHKVFLIDTLSVEASFILQNVQQAKLITQRDYNNLSDVSER ETKII------------------------------------------------------- -----------------------------------------KLLDKLIGRGEETCQEFID LLRQDCVLENFPVLEGHA------------------------------------------ ------------------------------------------------------------ ---------------------------------------IFA----SSV--QKVSQYKIT QNPRGICVIINNVDFT----------SMGERRGSDEDQNY-LAKVFRWLGFE-VVAHRNK TAAEMKNILQALGRT---VDGDCFVCCVLSHGVE-------EG-VCGTDGSLVSVDEIRN PFTGVNCQKLVGKPKLFFIQ--ACR----GQRK-QLRVNA--QA-----DGP-GDGESEM EV------------------D-G--------------------DDF-DITIPSDTDFLIA RSTTD--GHVSYRKPDEGSWFIQSLCRNLEKHCP------LGADIL-----------TIL LSVNNEVSIQG-------------LHSKQMPVHEVAMRMKLILPPV--NN---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MDKLYRDVQSG--------------EDKYRYKMD YPCMGTCVIINIKNFD-------LKTGLETRNGTDVDAAE-LEKTFSKLGYK-VTLVHDQ TADQIVDLLRDVSTQ-DHSNSGSFVCVLLSRGDE-------GG-IYGTDGSFVNLDELTK FVDGNGCRSLVGKPKLLFIQ--AAR----GNKL-DDGT----LS-----EGD-SM----- ----------------------D--------------------GQT-PSRIPVEADFLYA YSTTP--GFNAWRDTQNGSWFMQSLCEMLRRFS-------GQLELM-----------QIM TRVNNKVALEY---KTT----PGRSGKRQMPCIVSLLTKEFYFP---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >H_sapiens_ENSP00000286186 ------------------------------------------MKSQGQHWYSSSDKNCKV SFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFF LAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLF-------------------- ------------R----NLLYELSEGIDSENLKDMIFLLK-DSLPKTEMT----SLSFLA FLEKQGKIDEDNLTCLED-----LCKTVVPK-----LLRNIEKYK------------REK A--IQIVTPPVDKEAES-YQGEEELVSQTDVKTFLEALPQ-ESW---------------- -Q-NKHAGSNGNRATNGAPSLVSRGMQGASA-NTLNS--ET------ST--KRAAVYRMN RNHRGLCVIVNNHSFTS----------LKDRQGTHKDAEI-LSHVFQWLGFT-VHIHNNV TKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRF-------GA-VYSSDEALIPIREIMS HFTALQCPRLAEKPKLFFIQ--ACQ----GEEI-QPSVSI--EA-----DAL-NPEQA-- ----------------------P--------------------TSL-QDSIPAEADFLLG LATVP--GYVSFRHVEEGSWYIQSLCNHLKKLVP------RHEDIL-----------SIL TAVNDDVSRRV---D-------KQGTKKQMPQPAFTLRKKLVFPVP-----LDAL----- ---SL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >D_rerio_ENSDARP00000075650 ------------------------------------------------------------ --------MDKKESVDKICENKIFLLETLSVDANFILQHVQQAKLITLRDYNNLSDFPQR ETKII------------------------------------------------------- -----------------------------------------NLLDKLMGKGEETCHQFIA LLRQDCVLENFPMLKDHD------------------------------------------ ------------------------------------------------------------ ---------------------------------------IFD----SSV--QEISPYRII KNPRGICVIINNEIFS---------SGMMSRRGSDKDREY-LAKVFHWLGFE-VVEHNNK DTAEIRNILKDLGRT---VDGDCFVCCILSHGRR-------EG-VCGTDGNYLSIDEIRD PFTGVKCQKLVGKPKLFFIQ--GCR----GANSLQACVKV--EA-----DAG-NSKAK-- --------------------VEG--------------------DNL-DITIPSDTDFLIA RSTTN--GHVSYRHVREGSWFIQSLCRNLEKHCP------RGADIL-----------TIL LYVNNEVSSQK-------------SIRKQMPIYEVALTRKLFLRPV--NP---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_anatinus_ENSOANP00000006351 -----------------------------------------------------------M DFHRLLFSIGEELAADDLEALKFLCLDLIPRKKQENIQDALGLFRLLQEKGMLEEGKLFF LKELLFRIHRIDLLTSHLRTSQEDVARELEEPGRAQVSAYS------------------- ------------R----VLLFTLSDNVTREELKSITFFLS-NDLPRSRLDNKQTLMGIFI EMEKKGILGESNLDMLKK-----ICDKIDKT-----LLGKIDHYE------------ERR ADCTLHSSEHLTVLDRDMYIIPIIYDEIILLPTESSFRGHSGGEAE-------------- ---------------------------------------------------QNGDFYKMN SNPRGYCLIINNYNFQQARAEVPKLKKMKNRDGTDKDAEA-LSQIFKALAFS-PVVFEDQ TAEQILETLQSYQRM-DHSAQDCFVCCILSHGDR-------GV-VYGTDGQQASIRSLTS YFTGSRCPTLAGKPKLFFIQ--ACQ----GDAY-HLAVAL--ET-----DNG-TDKGTAA ASPAEP--------------D-A--------------------VFH-ERCIPDEADFLLG MATVS--NCVSYRIPSKGTWYIQSLCHHLRNLCP------LGADIL-----------TIL TKVNFEVSQKI---D-------LTNRGKQMPQPMFTLRKKLVLPLL-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_guttata_ENSTGUP00000010625 ------------------------------------------------------------ DFRKLLFEVSEALVTEELSALKFLSLDHVPRRKLEAIHEPKAFFEVLQEKDMIGAGNLFF LKELLYRIHRIDLLSTPLGCSREEMERELQLPGRAQVSAY-------------------- ------------R----QLLYGIAEDLTSEDVRSVKFLLQ-KQLPKNKLQENASMLQVFL EMEIKGIIKEDNMTTLKD-----ILQRFRAD-----IKKKIDAYE------------EKK KGLTGSAEVSLEL------PVSWIDSVDHIKQSTLGLPGEDRSLSF-------------- ---------------------------------------------------QLLEAYKMT SRPCGVCLILNNHNFAKAREGVLEHKHMKDRNGTDVDAAA-LRNVFSKLHFR-VEEYRDL TAEEIRETVNIFQSA-DHEDKDCFVCCILSHGKK-------GI-IYGVDGQEVPIRELTT SFTAQNCSSLAGKPKVFFIQ--ACQ----GDAF-HKGVAI--ET-----DSV-EEDSS-- ---LER--------------D-A--------------------RFQ-LDCIPAEADFLLG MATLQ--DYVSYRSPKEGTWYIQALCQHLEYSCP------RGEDVL-----------TIL TAVNQEVSKKT---C-------ERDAKKQMPQPSFTLRKRLIFPVN-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >E_caballus_ENSECAP00000004055 -----------------------------------------------------------M NFNSCLYNIGEQLDSDELASLKFLSLDHIPQRKQEPIQDALMLFQRLQEKRLLEESNLSF LKELLFRINRLDLLTTELDTSKEEMERELQSPGRAQISAY-------------------- ------------R----VMLFQISEDVNKLELKSFKFLLS-RELPKCRLDDDMILLDIFI EMEKRVMLGERNLDTLKK-----ICEQVNKS-----LLKKINDYE------------ELS REGRISLERSPDEFSNAS-LKCLQREGSLAGQAMSDSPGQQNSESQ-------------- ---------------------------------------------------TSDKVYRME SKPRGYCLIFNNHDFSAARRDVPKLQNIKDRNGTDLDAEA-LSMTFTELHFE-VVPYKNS TAKDICDALREYQEM-DHKKKDCFICCILSHGDK-------GI-IYGCDGQEASIYELTS YFTGSNCPSLAGKPKIFFIQ--ACQ----GDNY-QKGIAV--ET-----DSE-LTDAY-- ---LEM--------------D-S--------------------SFQ-KRCIPDEADFLLG MATVN--NCVSYRNPLEGTWYIQSLCQSLRERCP------RGEDIL-----------TIL TNVNFEVSSKD---D-------KKNMGKQMPQPTFTLRKRLVFPLN-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_cuniculus_ENSOCUP00000006164 -------------------------------ALVESGTVGDWVTVPGEGNGYXXXXXXXX XXXXXXXXXXEQLDSELL--LKF-ELDYIPQRKQEPIQDALMLFQRLQEKRMLEENNLAF LKELLFRIHRLDLLSTLLGTSKEEMVTELQIPGRAHISAYX------------------- -----------------XXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXX-----XXXXXXXX-----XXXXXXXXX------------XXX XXXXXXXXXXX--------XXXXXXXXXXXXXXXXXXXXXXXXXXX-------------- ---------------------------------------------------TSEEVYQMK SKPRGYCLIVNNYDFSIARREMPRHRNMKDRKGTEVDAEA-LSNTFTDLHFE-VVHYNDC TAKQICDILQSYQSM-DHKDRDCFVCCILSHGDK-------GI-IYGTDGQEACIYDLIS YFTGSKCSSLAGKLKVFFIQ--ACQ----GDKY-QQAVPA---I-----DSE-QQSYL-- --------------------D-S--------------------SFP-KRYVPDEADFLLG MATVN--NCVSYRNLFEGTWYIQSLCQSLRERCP------QGEDIL-----------SIL TKVNYKVSIKE-----------AGEKKKQMPQPTFTLTKRLLFPLD-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_rubripes_ENSTRUP00000044662 ---------------------------------------------------------CNM DFQARLLKVGNDLRKDEVRALVFLCSDILGCNP-AAVQSAGDLFSRLSDQDHLSEEQPHL LVELLGIIQRTKLL-RDHNLPRTGAQDL--------ISPY-SCKS--------------- ------------R----KLLYSLSEELTADDLKDIKFLLN-NKLPRGKLEE-VTTLEVFM ELEHRALISDTDLGFLES-----IIQPVCPV-----LLEKINQFN------------AQN CKMHLILHIFDSYLNQIQLNTQLKALW--LIKKF-DSFLVSFSSNESWIGGSGNRPT--- -NRCPLLTAASLLEQS-----------CSFN-TLQVG--CPD----VSV--QGVETYLMT AAKRGRCLIINNCNFRVS--------RLKKREGTMVDEAS-LDKVLKWLGFE-VEIQRDC TSKKMSSLIQELAKT-SQRDWDCVMCCVLSHGLE-------GG-VYGVDGGTVEIRKLME PFSGTNCPSLAGKPKIFFIQ--ACQ----GSRQ-QDIVYT--DA-----GTP-GHGYV-- ----DN--------------N-A--------------------VQA-KECIPSHADFLLG MATVP--SFVSFRDGTHGTWYIQSLCQNLADMVP------RGCDLI-----------SIL TKVNADVSKKV---A-----WIDSGHKTQMPQPAFTLTKKIVFPAP-----NTPHPV--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_familiaris_ENSCAFP00000017899 -----------------------------------------------------------M DFSKCLYNIGEQLDSDELASLKFLSLDYIPQKKQEPIKDPLMLFQRLQEKRMLEESNLFF LKELLFRINRLDLLMTYLDTSKEDMQQELQIPGRAQISAY-------------------- ------------R----VMLFQISEDVSKLELKSFKFLLS-REISRCKLDDDLNLLDIFI EMEKRVILGERNLDTLKR-----ICDQINKS-----LLKKITDYE------------ELN REQTMNLQRSLDEISNDM-SQLPIREGSVKILPMSDSLGEQDYESE-------------- ---------------------------------------------------TSDKVYRMK SKPRGYCLIFNNYDFSVARREVPKLQSIKDRNGTDLDADA-LSKTFSELHFE-IVHFKDA TAKKICEVLQSYQSM-DHSSKDCFICCILSHGDK-------GI-IYGSDGQEAPIYELTS YFTGSKCPSLAGKPKIFFIQ--ACQ----GDKY-QKGIAV--ET-----DSE-QKEAY-- ---LEM--------------D-S--------------------SYQ-KRYIPEDADFLLG MATVN--NCVSYRNPMEGTWYIQSLCQSLRERCP------RGEDIL-----------TIL TEVNFEVSNKD---D-------RKNMGKQMPQPTFTLRKKLFFPPN-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_pygmaeus_ENSPPYP00000014602 ------------------------------------------MKSQGQHWCSSSDKNCKV SFREKLLIIDSNLGVQDVENLKFLCVGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFF LAELLYIIRQKKLL-QHLSYTKEEVEGLL--PTRQRVSLF-------------------- ------------R----NLLYELSEGIDSENLKDMIFLLK-DSLPKTEMT----SLSFPA FLEKQGKIDEDNLTCLED-----L-KTVVPK-----LLRNIEKYK------------REK A--VQIVTPPIDKEAES-YQGEEELVSQTDVKTFLEALPQEESW---------------- -Q-NKHAGSNGNRATNGAPSLVSRGMQGASA-NTLNS--ET------GT--KGRKGYRMN RNHRGLC-LLNNHSFTS----------LKDRRGTHKDAEI-LSHVFQWLGFT-VHIHNNV TKGEMEEVLQEQKCNPAHADGDCFVFCILTHGKF-------GA-VYSSDEALIPIREIMS HFTALQCPRLAEKPKLFFIQ--ACQ----GEEI-QPSVSI--EA-----DAL-NPEQP-- ----------------------P--------------------TSL-QDSIPAEADFLLG LATVP--GYVSFRHVEEGSWYIQSLCNHLKKLVP------RHEDIL-----------SIL TAVNDDVSRRV---D-------KQGTKKQMPQPAFTLRKKLVFPVP-----LDAL----- ---SL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_mulatta_ENSMMUP00000037898 ------------------------------------------------------------ ---------------------------------------------------------MRI PTKWFYL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------FF--KRAPTYRMD RNHRGLCVIVNNHSFIS----------LRDRRGTHKDAEI-LKGVFQWLGFT-VHIYNNV TKGEMEEVLQKEKCNPAHADGDCFVFCILTHGED-------GA-VYSSDEALIPIREIMS HFTALQCPGLAEKPKLFFIQ--ACQ----GEKI-QLSKSI--EA-----DAL-NPEQA-- ----------------------P--------------------TSL-QDSIPVEADFLLG LATVP--GYVSFRHVEEGSWYIQSLCNHL------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >D_rerio_ENSDARP00000024255 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------EQYEMK GERRGVCLIINNYDFSAC--------GWLNREGTDIDHDS-LRDVFEWLGFE-ILTRRDC TGDQILQALMDLSTQ-DHTQADCVVCCILSHGRL-------ND-IIGVDGKAVPFKELME TLSPFRCSSLYQKPKLFFIQ--ACR----GTQN-QRAVFP--QT-----FTE-DEDVL-- ----AS--------------D-A--------------------GVP-RDSIPEMADYLMA MSTVP--WYASYRDKSKGTWFIQSLCDNLRLLVP------RGNDLL-----------SIL TKVNADVSKKS---D-------KSGLKKQMPQPEFSLTRTVVFPPP-----GLP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_musculus_ENSMUSP00000030747 ------------------------------------------------------------ ---------MDEADRQLLRRCRVRLVSELQVAELWDALLSRELFTRDMIEDIQQAGSGSR RDQAR------------------------------------------------------- -----------------------------------------QLVTDLETRGRQALPLFIS CLEDTGQGTLASLLQSGR-----QAAKQDPE-----AVKPLDHLV----------PVVLG PMGLTAKEQRVVKLDPSQPAVGNLTPVVLGPEELW------------------------- --------PARLKPEVLRPETPRPVDIGSGGAHDVCV--PGK----IRG--HADMAYTLD SDPCGHCLIINNVNFC-------PSSGLGTRTGSNLDRDK-LEHRFRWLRFM-VEVKNDL TAKKMVTALMEMAHR-NHRALDCFVVVILSHGCQASHLQFPGA-VYGTDGCSVSIEKIVN IFNGSGCPSLGGKPKLFFIQ--ACG----GEQK-DHGFEV--AC-----TSS-QGRTLDS DSEPDAVPYQEGPRPL----D-Q--------------------LDA-VSSLPTPSDILVS YSTFP--GFVSWRDKKSGSWYIETLDGILEQWA-------RSEDLQ-----------SLL LRVANAVSAK--------------GTYKQIPGCFNFLRKKLFFKTS-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >E_caballus_ENSECAP00000021726 ------------------------------------------MTSQGQNLNSSSDDNCTM DFRQKLLFIDSHLGDQDVERLRFLCRDCVSHKKLEKSSSALEIFNHLLAEDLLREEDSFF LAELLYIIKQKSLL-CHLCYTKEQVESLL--PARRRVSLF-------------------- ------------R----NLLYELSEGMDSDNLNSMMFLLK-DSIPKTQMT----SLSLLA HLEKQARIDEDNLTLLEM-----LCKNVVPN-----LMRKIEKYK------------REK A--AQVVTAPVDKETESLHHGEEELFSRSDIKKFSRALPQ-------------------- -P-WEHTHAGLGSLPLGN-SRVSKGWSSALA-SGIGS--IS------SS--KETPLYRMD RTHRGHCVVVNNHTFTS----------LADRPGTDKDAEC-LKSVFQWLGFS-VHRYDNV TKEGLEKVLQEYRNHPGHASGDCFVFCVLTHGKF-------GA-VYSSDGILIPIREIMS HFTAQRCPALAHKPKLFFIQ--ACQ----GEEV-QPSVSI--EA-----DAV-NPENV-- ----------------------T--------------------PSL-EDSVPVEADFLLG LATVP--GYVSFRHVKEGSWYIQSLYNNLKDLVP------RREDIL-----------SIL TAVNDDVSRQV---D-------IYGKKKQMPQPAFTLRKKLVFPVP-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_gorilla_ENSGGOP00000000205 ---------------------------------------------------YILLPFEKM DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY-------------------- ------------R----VMLYQISEEVSRSELRSFKFLLQ-EEISKCKLDDDMXLLDIFI EMEKRVILGEGKLDILKR-----VCAQINKS-----LLKIINDYE------------EFS KERSSSLEGSPDEFSNG--------EELCGVMTISDSPREQDSESQ-------------- ---------------------------------------------------TLDKVYQMK SKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGA-LTTTFEELHFE-IKPHDDC TVEQIYEILKIYQLM-DHSNMDCFICCILSHGDK-------GI-IYGTDGQEAPIYELTS QFTGLKCPSLAGKPKVFFIQ--ACQ----GDNY-QKGIPV--ET-----DSE-E-QPY-- ---LEM--------------DLS--------------------SPQ-TRYIPDEADFLLG MATVN--NCVSYRNPAEGTWYIQSLCQSLRERCP------RGDDIL-----------TIL TEVNYEVSNKD---D-------KKNMG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >X_tropicalis_ENSXETP00000008971 -----------------------------------------------------------M DFNSMLLSIDDGLGREDIEALKFLCRDVLRKNKLLSVRSGQELFQQLMTEDLINEDNFFL LKELLYIINHHSLL-RNLGTNKEKVQKAL--PRQGRISPYR------------------- -----------------QMLYQLSENIAGDDEKRVYFLLP----LQKKHKENKTFLEVLC QLERENSITEDDVELLED-----IFKKVAPD-----LLKIIEKYK-------ERGDKLHQ TENHLIDPSAPPEDEHELINPPLSIQVSSKDSELWDKGTESLIEH--------------- --------TGMIHEEAEKEDDKSGNINHQLSDLRLNS--EMT----PQA--NKEEFYDMN HKHRGYCLIIDNSVFM----------KGNRREGSDKDAGA-LSDVFSWLGLE-VDIFENL MSEQIRDCLKRFKSR-DHSERDCFVCCILTHGES-------GT-VMGSDDKEVSIREIMS YFTAISCTSLVLKPKLFFIQ--ACQ----GKFT-HPSSKV--EA-----DAI-VPEEN-- -------------------------------------------KKY-VVNVPKDADFLLG MSTVD--GYAAYRHTREGSWYIQALCKNLVELVP------RGEDIL-----------AIL TKVNKDVSLKE---G-------QQGILKQMPQPSYTLLKKLRFPVP--DVPFRPKTCQEN SP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_rubripes_ENSTRUP00000045375 ------------------------------------------------------------ ---------MEERHKKILQRNRTNLVGELDPSSLYDGLIEKRVFTHDMIDEIKSS--GTR RDQAR------------------------------------------------------- -----------------------------------------QLIRDLETRGSRAFPLFLE CLQETGHHTLVELLQDGG-----PAVQIQPPTPVPIDRPVIQPLP------VCKSAIRSR VLRGTMTVKAAPPVDVVR------------------------------------------ ----------RDKAPVIPVPQPSTAPSPSPEREYMRLKPQGR----IRR--DSIQSYKMD ANPSGHCLIINNVDFE-------PRSELNDRKGSNTDCDR-LESRFKALNFI-VKVKTNL KQRQIKHELSALSKM-DHSQYDCCVVVLLSHGTEVSHSRFPGA-VYGVDGQFVPVQHITT YLNGQHCPSLQGKPKLFFIQ--ACG----GDEK-DTGFEV--SP-----DEF-EPPVVSA HDQTDAIPMSSSSDSLS-MSD-E--------------------PDA-RASLPTPSDILVS YSTFP--GYVSWRDTQSGSWYIETLDRILEENA-------ATDDLV-----------TML MMVNHEVSQN-----------QAKGLYKQMPGSFNFLRKLLYFQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_troglodytes_ENSPTRP00000048878 ------------------------------------------MKSQGQHWCSSSDKNCKV SFREKLLIIDSNLGVQDVENLKFLCIGLVP-KKLEKSSSASDVFEHLLAEDLLSEDDPFF LAELLYIIRQKKLL-QHLNYTKEEVERLL--PTRQRVSLF-------------------- ------------R----NLLYELSEGIDSENLKDMIFLLK-DSLPKTEMT----SLSFLA FLEKQGKIDEDNLTCLED-----LCTTVVPK-----LLRNIEKYK------------REK A--VQIVTPPVDKEAES-YQGEEELVSQTDVKTFLEALPQ-ESW---------------- -Q-NKHAGSNGNRATNGAPSLVSRGMQGASA-NTLNS--ET------ST--KRATVYRMN RNHRGLCVIVNNHSFTS----------LKDRQGTHKDAEI-LSHVFQWLGFT-VHIHNNV TKVEMEEVLQRQKCNPAHADGDCFVFCILTHGRF-------GA-VYSSDEALIPIREIMS HFTALQCPRLAEKPKLFFIQ--ACQ----GEEI-QPSVSI--EA-----DAL-NPEKA-- ----------------------P--------------------TSL-QDSIPAEADFLLG LATVP--GYVSFRHVEEGSWYIQSLCNHLKKLVP------RMLKFLEKTMEIRGRKRTVW GAKQTQISATS---L-------PKAISAQTPRPPMHRWSSVS------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_domestica_ENSMODP00000005512 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NDL TCN---ELLDSVSKE-DHSQSSSFIGAVLSHGEE-------GV-IFGPDE-SVELKRLMC FFRGDKCRRLRGKPKLLIIQ--ACR----GTEL-DCG-----ET-----DSG-TD----- ----------------------E--------------------DIA-CQKIPVEADFLYA YSTAP--GSYSWGNSKGGWWFIQALCA----HA-------HEFEIM-----------QIL TRVNGKVATEF---ESYSLD-ISFHAKKQVPCITSILTKKL------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_cuniculus_ENSOCUP00000011835 ------------------------------------------------------------ -------------------------------MSSAPGLRGAR------------------ ------------------------------------------------------------ ------------------------------------------------------------ --LAGGKQNMTETDAFY------------------------------------------- ------------------------------------------------------------ ------------------------------K-REVFD--P-------------AEEYKMD HRRRGIALIFNHERFF-------WHLMLPERRGTNADRDS-LARRFSDLGFE-VKCFNDL KAEELLLKIHEVSTS-SHLDADCFLCVFLSHGEG-------NH-IYAYDA-KIEIQTLTG LFKGDKCQSRVGKPKIFIIQ--XXX----XXXX-XXXX-X--XX-----XXX-XXXXXXX XXXXXX--------------X-X--------------------XXX-XXXLPAGADFLMC YSVAE--GYYSHRETVNGSWYIQDLCEMLGKYG-------SSLEFT-----------ELL TLVNRKVSQRR---VDFCKD-PSAIGKKQVPCFASMLTKKLHFFPK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_guttata_ENSTGUP00000014729 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------FACILLNHGEE-------GL-IYGTDG-PMAIKSLTA LFRGDKCKSLIGKPKLFFIQ--ACR----GSEF-DEGI----QT-----DSG-PAN-DTL ET--------------------D--------------------ANP-RYKIPVEADFLFA YSTVP--GYYSWRNPGRGSWFVQSLCSVLNEHG-------KQLEIM-----------QIL TRVNYVVATNF---ESQSDD-PRFSEKKQIPCVVSMLTKELYF----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_domestica_ENSMODP00000004412 ------------------------------------------------------------ ---------MEESQRELFQKNRLRLVCELQVEPLWDLMLDRELFTRDMIEDIQRA--GTR RDQAR------------------------------------------------------- -----------------------------------------QLVTDLQTRGKRALPIFIS CLEATGQWDLAALLSESN-----TTLTQQPDPI---DIKPVEMIR---------SGGLRS TGRYTSMVSLHLLLLANSPFLYFIDAVLVSAHNLF------------------------- ----------PLELIKRQPTFSKVLSLLYKLRFPFCP--PP----------QVGQVYTLN SDPCGYCLIINNVDFC-------ASSGLSSRKGSNIDCEK-MHNRFQALHFA-VEVERNL SAKGMGAALQQLAER-DHSALDCCVVVILSHGCQASHIQFPGA-IHGTDGASISVERIVN IFSGSRCPSLGGKPKLFFIQ--ACG----GDQR-DHGFQV--SS-----NIP-EDKSPGS DPETDATPFQNNF-------D-Q--------------------PDA-VASLPTPSDILVS YSTFP--GFVSWRDPKSGSWYIETLDRVLEEWA-------DREDLL-----------HML LMVSNAVSAR--------------GTYKQIPGCFNFLRKRFFFKTK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >B_taurus_ENSBTAP00000038128 -----------------------------------------------------------M ALTQCLYNIGEQLGSDDLAALKFLSRDHIPYRKQEPIKDALMLFQRLQEKRMLEENNLSF LKELLFRVNRLDLLLNYLYTSEEEMKRELQIPGRAQISAY-------------------- ------------R----ILLFQISEDVNKVELKDFKFFLS-QEIAKCKLDDDMTLLDIFV EMEKRTILGEENLDTLKR-----ICEQVNKS-----LLKKIYDYE------------ELR KERRMSLERDPYAFSNDM-SQSLPEEGYSKMPAMSDSP-EQDSELQ-------------- ---------------------------------------------------TSDTVYRMT SKPRGYCLIFNNYDFSIARKQVPELHDLKDRTGTDFDADA-LDKTFRELHFE-IVHYKDL TAKGICEVLESYQKK-DHKNKDCFICCILTHGNK-------GI-IYGSDGQEASIYELTS YFTGLKCPSLIGKPKIFFIQ--ACQ----GDKY-QKGVAV--ET-----DSE-QMEAY-- ---LEV--------------D-S--------------------SPQ-KRYIPDEADFLLG MATVK--NYVSYRNIWNGAWYIQSLCQNLRERCP------RGEDIL-----------TIL TKVNFEVSKLD---D-------KQRMAKQMPQPTFTLRKKLFFPLN-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_gallus_ENSGALP00000013571 ---------------------------------------------------------MSS DFRKLLFDISEALATEELAALKFLSLEHVPVRKQEDTEEPKAFFEVLKEKGMIEVEDLFF LKELLYRINRIDLLASHLGSSREEMERELQVPGKAKVSAY-------------------- ------------R----QLLYGIAEDLTPDDVRSIKFLLQ-EKLPKNKLQDNASMLKVLV EMERNGIIKEDDLTMLKS-----ILKAFRAD-----LKKKIDNYE------------EKT KGWPWKSSCFPNK------TQALSISENLAVSSLIDNKESQESQSEWY------------ --------------------------------SAGIF--PPH----VQI--LLVESYKME NNPHGYCVILNNYRFKNP---------NETRKGTVEDGKA-LKRVFKWLQFD-TIEYMDL EAKQIFAKVNEYSKK-DHSNMDCFVCFILSHGEK-------GK-IKGVDNELVNIKDLLS CFSGSNCPSLAGKPKLFFIQ--ACQ----GSVG-HPAVTV--KE-----DCS-GHLET-- --------------------D----------------------AIP-ALSIPDQADVLVG MATVE--DFECYRSIETGSVYIQCLCDKMELLCP------LRKDLI-----------TIL TEVNKEVGRR------------VLNGWKQMPKITSTLRKQFIFQIP--QCQ--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >B_taurus_ENSBTAP00000003205 ------------------------------------------------------------ ---------MNEADRLLLRRYRVRLVGELQVASLWDALLSRELFTPDMIEDIQRAGSGSR RDQAR------------------------------------------------------- -----------------------------------------QLILDLETRGSQALPLFIS CLEDTGQDTLASLLKTSR-----QAAKQ-------------------------------- ----------------SKPSQGKLAPVVLGPEELW------------------------- --------PAKLRPEVLRPEVPRAVDAGSGGFTDVCP--QDR----AKG--NADLAYVLN ADPCGHCLIINNVNFC-------RESGLRARTGSNIDCER-MRQRFHLLQFV-VEVKCDL TAKQMVQALMQLARQ-DHSALDCCVVVILSHGCQASHLQFPGA-VYGTDGCPVSVERIVN TFNGTGCPSLRGKPKLFFIQ--ACG----GEQK-DHGFEV--ES-----TSP-EDKTPSS DPEADATPFQEGPRSI----D-E--------------------PDA-VSSLPTPSDILVS YSTFP--GFVSWRDPKSGSWYIETLDSIFEQWA-------HCEDLQ-----------TLL LRVANAVSVK--------------GIYKQMPGCFNFLRKKLFFKT--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_nigroviridis_ENSTNIP00000013855 ------------------------------------------------------------ ---------MEERHKKILQRNRINLVSELEPLNLYDGLIEKGVFTHDMIDEIKCS--GAR RDQAR------------------------------------------------------- -----------------------------------------QLVRDLETRGSRAFPAFLE CLKETGYHSLAELLQNGA-----PTVQIQPPTPIPVDRPVIQPLP--------------- -----ISPPLVPP----------------------------------------------- ------------EEPVSPVPKPSTPGRASPEVEYVTL--KGR----IRR--DSLQSYRME ANPLGHCLIINNVEFE-------PKSGLSNRNGSNVDCDR-LERRFKALNFT-VKVKTNL KQRQIRQELSALSKV-DHSQYDCCVVVILSHGTEVSHSRFPGA-VYGVDGQFVPVQHIAT YLNGQYCPSLQGKPKLFFIQ--ACG----GDEK-DTGFQV--SP-----DEF-EPPVVGA DDQTDAIPVSSSSDSLS-MSD-E--------------------PDA-RASLPTSSDILVS YSTFP--GYVSWRDPKAGSWYVETLDRVLEENA-------ALHDLV-----------VML TMVNDEVSQN-----------QAKGLYKQMPGSFNFLRKRLYFIAQP------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_cuniculus_ENSOCUP00000003895 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------N----SLHLLE HLEKRDDIHEDNLTYLED-----LCKKVAPS-----LMRIIEKYK------------NEK X--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVT-------------------- ------------------PALASVELLRAPA-DFLRL--ET------ST--REANVYRMD RKHRGRCVIVNNEIFTT---------YLSDRRGTQRDAE--QKLVFQWLGFK-VHKCDNK TKEDLEALLQEEKHHPDHDDGDCFVFCVLTHGIF-------GA-VYSSDGVLIPIREIVS HFTAKQCPGLAGKPKLFFIQ--ACQ----GKEI-QSSAPI--EA-----DAV-NPECV-- ----------------------P--------------------PSL-QDSIPVEADFLLG LATVP--GYASLRHVENGSWYIQSLCNHLKALVP-------HEDIL-----------SIL TAVNNDVSRQA---D-------KSGRMRQMPQPAFTLRKRLVFPVP-----QEEP----- ---SF------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_domestica_ENSMODP00000036251 -----------------------------------------------------MEDNSKI KFNQQLLSINEKLEPEEIEALKFLCSDLISPRNLEDIESGHQLFQKFMDEDLLNEGDYFL VAELLFLIKHHNLL-QKIGYTKEKVKKEL--SSKRKISSY-------------------- ------------R----VMLYNLSEEITTEDFEHIKFIMK-EHIPKTLKT----FLSLLR HMEKQNLLSENNLEILVN-----ICKPLSIN-----LIKRIEQYK------------SEK GELPEFELIP--------YHGCGVISEQVSLMTFLSLLPLFSWSR--------------- ----KHLPFSQQNEANNSLEEVTGLWAQGAE-GGTLF--SD------MT--NEAKFYRMD HSHRGHCIIFNNFEFQT----------MKRRRGSCKDADE-LKSVFEWLGFT-VKIHPNT EKREMEDILQQCSTSPEHRESDCFVCCVLTHGES-------GS-VFSSDEEKIAIRELTS YFKAHRCPGLANKPKLFFFQ--ACQ----GPDI-QESMLL--EE-----DAKISPPIQ-- ----------------------V--------------------ETP-QRYIPVEADFLLG MATVD--GCCAIRHTIKGSWYIQALCHRLKCMVP------RNEDIL-----------TIL TEVNNDVSQLT---D-------AEGKKKQMPQPAFTLRKKVVFPVP-----PLSP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_latipes_ENSORLP00000005993 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MS HQRVGKCIIINNKNFD-------DNTGMNVRNGTDRDAGE-LYKCFKSLGFD-VSIYNDQ TCDKMEHLLKEASQE-DHSDSSCFACILLSHGEE-------GM-IYGTDG-AIPIKTMTS LFRGDKCKSLVGKPKLFFIQ--ACR----GSEF-DEGV----QT-----DSG-PPN-DTI ET--------------------D--------------------ANP-SHKIPVEADFLFA YS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_aculeatus_ENSGACP00000007379 ------------------------------------------------------------ ---------MEEIHKRILQRNRINLVRDLDPSSLYDGLLEKGVFTQDMIDEIKSA--GTR RDQAR------------------------------------------------------- -----------------------------------------KLVQDLETRGSRAFAMLLL CLEETDQHGLAELLQRAA-----PAVQIWPAAP---NQPFVLMLN-----------SREK TTSPSIQYRNPVPVHLTH------------------------------------------ ----------------------CDAHVTAPERENTLTRPPGR----TRR--DSIQSYKMD ASPCGHCLIINNVEFE-------PDSELSNRKGSNIDCDK-LEKRFKALNFI-VEVRTNL KQRQIKHALSALSKK-DHSQCDCCVVIMLSHGTEVSHNRFPGA-VYGVDGQHVPVQLITN YLNGQHCPSLQGKPKLFFIQ--ACG----GGER-DTGFEV--SP-----DEV-EPSIGGA DDQTDAIPMSSSSDSLS-LSD-E--------------------VDA-RATLPTPSDILVS YSTFP--GYVSWRDTQSGSWYVETLDQVLEQNA-------ATDDLV-----------TML MMVNHEVSQN-----------SAKGLYKQMPGSFNFLRKLLHFQTHA------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >R_norvegicus_ENSRNOP00000017972 ------------------------------------------------------------ ---------MEEADRQLLRRCRVRLVRELQVAELWDALLSRELFTRDMIEDIQRAGSGSR RDQAR------------------------------------------------------- -----------------------------------------QLVIDLETRGRQALPRFIS CLEDTGQGSLASFLQSSG-----QAAKQDPE-----AVTPLDHLV----------PVVLG PMGLKSKEQKVVKLDPSQPALGNLTPVVLGPEELW------------------------- --------PTRLRPEVLTPETPRPVDIGSGRAHDVCT--PGK----IER--HADMAYTLD SDPCGHCLIINNVNFC-------PSSGLSTRIGSHVDCEK-LQHRFCWLRFM-VEVKNDL TAKKMVTALMEMAHR-DHRALDCFVVVILSHGCQASHLQFPGA-VYGTDGCSVSIERIVN IFNGTGCPSLGGKPKLFFIQ--ACG----GEQK-DHGFEV--AF-----TSS-QDKAFDS DSEPDAVPYQEGPRTL----D-Q--------------------LDA-VSSLPTPSDILVS YSTFP--GFVSWRDKKSGSWYIETLDGVLEQWA-------RSEDLQ-----------SLL LRVANAVSEK--------------GVYKQIPGCFNFLRKKLFFKLH-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_guttata_ENSTGUP00000017449 ------------------------------------------------------------ ---------MEERQRRALRRGRARLVAALRVEPLWEPLEQRGLFTRPMLEELQSA--GSR GEQAR------------------------------------------------------- -----------------------------------------QLIIDLETRGKQAFPAFLS ILRDTGQGHLAEMLMQEC-----ESRPVPPQLP---DLRPVELEL--------------- ------------------------------------------------------------ ---------QEANQRCAVVLQTAARDVAAGIPLTVGK--SPE----VMS--FIILDYEMK ADPCGHCLILNNVNFC-------RDSGLSTREGSDIDCEK-LERRFKALCFT-VLTRRDL KAQEMVLELLKLSRQ-DHSALDCCIVVILSHGCQTSHIQFPGG-VYGTDGKPIPIEKIVN YFNGSSCPSLRGKPKLFFIQ--ACG----GEQR-DQGFVV--DC-----DSP-KEEALGD SLESDAIPFRVPSDNV----D-E--------------------PDA-IASLPTPSDILVS YSTFP--GFVSWREKSSGSWYVETLDSVLEQYA-------HSEDLL-----------SML VRVAHAVSAR--------------GRYKQIPGCFNFLRKKFFFVCR-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_anatinus_ENSOANP00000015596 ------------------------------------------------------------ --------------------------------------------------------AGTR RDQAR------------------------------------------------------- -----------------------------------------QLVTDLETRGRRALSVFIS CLRETDQHALAALLSEGC-----QAPQVTPV-----DIRPVEIIR--------------P GGQGDVCKYSKIHPKCYSPPLPFQSTSPLRGKEQW------------------------- --------TGSVKPFVPVPSTTK-------REQEATR--PGE----KQG--MAIKVYSLK SEPCGHCLIINNVDFS-------LGSGLSTRTGSDVDCEK-MKRRFRLLHFE-VAVERNL TAEEMVKALNKLAKK-DHSALDCCVVVILSHGYQASHIQFPGG-IHGTDGESISVETIVN YFNGSRCPSLGGKPKLFFIQ--ACG----GEKK-DPGFEV--NL-----DSP-EDHPTGS DPESDAAPFQAAPEDY----D-E--------------------PDA-VASLPTPSDILVS YSTFP--GFVSWRDTQSGSWYIETLDSVLDQWA-------HTEDLL-----------TLL LRVSNGVSSK--------------GKYKQIPGCFNFLRKRLFFNTK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_gallus_ENSGALP00000002083 ------------------------------------------------------------ ---------MEEAQRSALRRGRVRLVEGLRPEVLWGPLQARGVFTSAMVEDMQST--GTR REQAR------------------------------------------------------- -----------------------------------------QLVIDLETRGKQAFPIFLS ILRDTGHGDLADMLDEGC-----GSPMSPPV-----DLRPVQLEL--------------- ------------------------------------------------------------ -PGERRDKSVSTAERLSIPVQPESERFRMPPAPAQAC--PTG----LAG--ECSEVYQLR ADPCGHCLIFNNVSFS-------RDSDLSTRAGSDIDCEK-LEKRFRSLCFH-VRTLRNL KAQEIDVELRKLARL-DHSALDCCLVVILSHGCQTSHIQFPGG-IYGTDGKIIPIERIVN YFNGSQCPSLRGKPKLFFIQ--ACG----GEQK-DQGFEV--DC-----ESP-QDETCRR SIESDAIPFQAPSGNE----D-E--------------------PDA-VASLPTPGDILVS YSTFP--GFVSWRDKVSGSWYVETLDSVLEHYA-------RSEDLL-----------TML LRVSDIVSTK--------------GRYKQIPGCFNFLRKKFFFLCK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_guttata_ENSTGUP00000010628 ------------------------------------------------------------ -FRQQLFLISENLVTEDVAALKFLCTDLLHLRKLEGVKLATDIFRLLMAQEYLNAEDTFL LAELLYRIRCHSLL-KKIGYTKEKVQEHL--SEKGRISPY-------------------- ------------R----QMLYELAENITSEMLKEIIFLLR-NHLPKG-----WSALDLLT LLEKQGLLTTDNVKILED-----VCMTVSPD-----LLETINCYK------------KGK ------------------------------------------------------------ ---------------------------------------------------GEKFIISLH GDFIKSFPLASNFPFIF-----------------HLFTEQ-LERVFTWLGLD-VMTSTDL TSGEIINLMKTWQHKQDHEDRNCFICCILSHGKS-------GA-ICGTDDRPVSIRTLMS HFTAKQCPQLAAKPKLFFIQ--ACQ----GNKI-QDPVYV--NT-----DGP-TPDLSSM QE--------------------S--------------------VSL-SESIPEEADFLLG MATVD--GCVAFRHIEEGSWYIQALCSKLQLLVP------RGEDIL-----------SIL TQVNEDVARRD---S-------PSGKKKQMPQPAYTLRRKFIFPIP--M----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_intestinalis_ENSCINP00000024485 ------------------------------------------------------------ EFRLLLHQICEGLTGENVSMMKFLCKDAIPRSR--ELETALDFMEYFEAKGWIQEGDLGF LAEVLYRINRHDLLKLLPGVKNRRDYEENFQAQQNNFTTYR------------------- -----------------VVCFMLADELTEGDLKILKRLCA-GKMSKANVRRSVDVLSWLT CMEEEDLLSEGDLDFIMS-----ILQHLDNQ-----KPYKLFQRV--------------- -------------------------RMNDNTVTLPKNQQKSNAFQPNSHLPVASGFNSLS KQEYNHTSKLEPQYVSMENHRAFNGGYNQYNNYQSEI--KDT----STM--GILDKYPM- -ERRGYCLIINNENFE-----------RQDRTGSGNDTER-LENLFKEFGFI-LDVRKDL DQREMEKVIQEYTKK-DHSDKDCFVCVVMSHGLS-------GC-VYGVDGLSLSTSKISK SFRPGMCSSLTGKPKIFFFQ--ACQ----GDRT-MDGHSA--PV-----DDV-ESDGA-- ----------------------A--------------------SHG-RQVLPSESDFLIG HSTVP--GYLSYRSRTDGSWFISTLVDSLEKYH-------EKEDLL-----------SIM INVNQEMASK---------------PYKQMPMPIATLRKKVFFSKQ--NSNSSSNQNCNT P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_elegans_C48D1.2 ------------------------------------------------------------ --------MMRQDRRSLLERNIMMFSSHLKVDEILEVLIAKQVLNSDNGDMINSCGTVRE KRR--------------------------------------------------------- -----------------------------------------EIVKAVQRRGDVAFDAFYD ALRSTGHEGLAEVLEPLA-----RSVDSNAV-----EFECPMSPASHRRSRALSPAGYTS PTRVHRDSVSSVSSFTSYQDIYSRARSRSRSRALHSSDRHNYSSPPVNAFPSQPSSANSS FTGCSSLGYSSSRNRSFSKASGPTQYIFHEEDMNFVD--APT----ISRVFDEKTMYRNF SSPRGMCLIINNEHFE----------QMPTRNGTKADKDN-LTNLFRCMGYT-VICKDNL TGRGMLLTIRDFAKH--ESHGDSAILVILSHGEE-------NV-IIGVDDIPISTHEIYD LLNAANAPRLANKPKIVFVQ--ACR----GERR-DNGFPVLDSV-----DGV-PAFLRRG WDNRDGPLFNFLGCVRP-QV-----------------------QQV-WRKKPSQADILIA YATTA--QYVSWRNSARGSWFIQAVCEVFSTHA-------KDMDVV-----------ELL TEVNKKVACGF---Q----TSQGSNILKQMPEMTSRLLKKFYFWPE--ARNSAV------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_intestinalis_ENSCINP00000028692 ------------------------------------------------------------ ----------------------------MSENKEKDIRESWSQENLPEAGH--------- ------------------------------------------------------------ ------------------------------------------------------------ EIKTELDLNLDFSRSDAT-----DAGGFDPG-----SEGTITEIG--------------- ------------------------------------------------------------ ----------------------DTDQNETIK-RGFIS--LDE----LGE--NFDFCYNMQ HKKRGLFVVFNQMKFD-------KHLKLSERTGSDKDAAA-LLKTAELLGFE-TEEYLDL ERKQIRRKLYELSEM-DHGDHDCFACAILTHGGK-------DNILYSHDD-EMKLKDFTT PFEADKCRSLASKPKLFFVQ--ACR----GDLL-DRGAKV--IH-----LKQ-STG---- -DVLDR--------------NPS--------------------KVE-SYTIPVQADFLIS QATAP--DYYAWRSSDKGSIFIQTLCSVFERYSD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_rubripes_ENSTRUP00000024467 ------------------------------------------------------------ MDLRLLSQIDAQLDSLEVAALCFLCRDAVSPKSREGITDARGLFKKLHEKRLLE--NSSF LSQLLHTIHRKDLLCLLEADSSQPEETDARPLLSEYR----------------------- -----------------VMLYKLYENLDREDLKKLKFLLS-DQLGRRQIELCKTVLDVFT EMEKKGLLSNTKLDKLHS-----VLKEVDQR-----LAATVHDFM--------------- -----------------------------------------------QPLRGILVPRGPG TPPPAVMSMVIPVRLAVPETQSRGTEQNVSPDAESIF--QSS----PPA--DDNEYYALI HNPRGLCVVFNNETFL-------PGANLPRRGGTMEDQKR-LRSVFTKFGFT-VQVHNDF TAEAILRELKRLGKR-DFMNEDALVVCVLSHGLK-------GC-IFGTDGEEVSLQDFTQ PFVSSQAPTLAGKPKLFFIQ--ACQ----GEKL-QKGYAA--WP-----PRP-EQEMAKA ESQLEE--------------DAG--------------------PVK-AKVVADSADFLIG MATVE--DYKSFRNTKNGSIYIQELCNQLQKSAESP----GHDHIL-----------DIL TRVNREVSEG------------EFLNHKQMPEPKYTLTKKLVLKYL-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_mulatta_ENSMMUP00000040583 ------------------------------------------------------------ ---------MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFKPHMIEDIQRAGSGSR RDQAR------------------------------------------------------- -----------------------------------------QLITDLETRGSQALPSFIS CLVDTGQDMLASFLRTNR-----QAVKL-------------------------------- ----------------SKPTLENLTPVVLRPE---------------------------- ----------IRKPEVLRPETPRPVDIGSGGCGDVGA--PES----LRG--NADLAYVLS MEPCGHCLIINNVNFC-------RESGLSTRTGSSIDCEK-LQRRFSLLHFM-VEVKHDL TAKEMVLALLELARR-DHSALDCCVVVILSHGCQASHLQFPGA-VYGTDGCPVSVERIVN IFNGTSCPSLGGKPKLFFIQ--ACG----GEQK-DHGFEV--AS-----TSP-EDESSGS NPEPDATPFQEDLRTF----D-Q--------------------LDA-VSSLPTPSDIFVS YSTFP--GFVSLRDPKSGSWYIETLDNIFEQWA-------HSEDLQ-----------SLL LRVADAVSVK--------------GIYKQMPGCFNFLRKKLFFKTS-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >R_norvegicus_ENSRNOP00000040783 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MENNKTLVDSKS------------------------------------------- ------------------------------------------------------------ ---------------INYFE----VKTHRSKPMDSGV--------------DLNSSYKMG YSKMGLCIIINNKNLL--------KTEMTSRSGTDVAAANRMSETFMVLKYK-VRNKNDL THEEIMELMDNVSKE-DHSERSSFVCVIPRHGDK-------GL-IFGTNR-PVDLEKLTS FFRDDYCQSLTGKKKLFITQ--DCQ----GTEL-DCGI----ET-----DSG-TE----- ----------------------D--------------------GMS-CQKIPVEANFLYV YSTKP--NYYSW------SWFIHSLCTMLQLCT-------HKLEFM-----------HIL THANRKVATEF---KSFSLG-GTFHKKKQIPCILSMLPKELYFYH--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_familiaris_ENSCAFP00000023986 ------------------------------------------------------------ ---------MDEAERRALRRCRVRLVRELQVAALWDALLSRELFTAAMVEDLQHAGSGSR SDQAR------------------------------------------------------- -----------------------------------------QLVIDLETRGSQALPLFIS CLEDTGQDALASCLTMSR-----QAVKQNPE-----ATRPLD-LM----------PVVLG PTRLTPEDLR--GKDPSKLTPGKLAPVVLGPA---------------------------- ----------ELQPQVVRPSVPRPTDNGSGRFSDVCE--YQESGWWVAG--PIKLAYALN ADPCGYCLIINNVNFC-------PESRLTARGGSNIDCEK-LQRRFCLLRFT-VEVKWDL TAKQMVQALVELARR-DHSALDCCVVVVLSHGCEASHRQFPGA-VYGTDGCPVSIEKIVN IFNGTGCPSLGGKPKLFFIQ--ACG----GEQK-DHGFAV--AS-----ASP-EDRSPGS DSEPDAVPFQEGPGPF----D-Q--------------------LDA-VSSLPTPSDIFVS YSTFP--GFVSWRNTKSGSWYVETLDGVFEQWA-------HAEDLQ-----------TLL LRVANAVSQK--------------GVYKQIPGCFNFLRKKLYFKM--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >E_caballus_ENSECAP00000015102 ------------------------------------------------------------ ---------MNEADRQLLRRSRLRLVRELQVDSLWDALLTRELFTPDMIEDIQR--SGSR RDQAR------------------------------------------------------- -----------------------------------------QLIIDLETRGSQALLLFIS CLEDTGQDTLASFLRTSS-----QAAKQNPE-----AIRPSD-LP----------PVVLG PVGLKPEELTAVKQDPSKLTPGKLTPVVLGPEELW------------------------- --------LAKLRPEVLRPEVPRPVDIGSGGFSDVRA--QDR----LRG--NADLAYVLN ADPCGHCLIINNVNFY-------LASGLGRRVGSDIDCEK-LRQRFSLLHFM-VEVKGDL TAKQMLRALGELARR-DHGALDCCVVVILSHGCQASHLQFPGA-VYGTDGCPVSIESIVN IFNGTGCPSLGGKPKLFFIQ--ACG----GEQK-DPGCKV--DS-----TSP-EDRTPGS DSEPDAVPFQEGPGTF----D-Q--------------------PDA-VSSLPTPSDIFVS YSTFP--GFVSWRDPKSGSWYVETLDGVFEQWA-------HSEDLQ-----------TLL LRVAHAVSEK--------------GVYKQIPGCFNFLRKKFFFKTY-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >D_rerio_ENSDARP00000047019 ------------------------------------------------------------ ---------MEQKHRQILQRHRLNLVKALNPEDVCDKLLSKGVFTQDMIDEIQSK--ATR RDQAR------------------------------------------------------- -----------------------------------------QLVKDLETRGSLAFPAFLD SLRETGHNDLAELLQSGDGVHRPPVISVQPSP----IPLPVQNLN-----------HTEK PDKPDIASPRLVP----------------------------------------------- ----------------LRPESLPVHKTYSPPSETVVR--PTR----PRR--DSIQCYKMD ASPCGVCLIINNINFE-------KASELNDRKGSNIDCDK-LEKRFKALNFE-VTVKRNL KSKRIRHEMASLAKK-DHSTYDCCVVIILSHGTEASHNRFPGA-VHGVDGPAVPIQIITN YLNGQNCPSLQGKPKLFFIQ--ACG----GGEK-DIGFEV--SP-----DDV-QPSIGGI DDEMDAIPMSSSSDSLSTASD-E--------------------LDA-RASLPTPSDILVS YSTFP--GYVSWRDTEAGSWYVENLDRVLEENA-------ITDDLV-----------TML MLVNDAVSQI-----------SAKGLYKQMPGSFNFLRKLLYFQSSQS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_troglodytes_ENSPTRP00000056642 ----------------------------------RGGRPWGGGGSWGLGRAAEARKRTEA AWSLSWLLAMDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSR RDQAR------------------------------------------------------- -----------------------------------------QLIIDLETRGSQALPLFIS CLEDTGQDMLASFLRTNR-----QAAKL-------------------------------- ----------------SKPTLENLTPVVLRPE---------------------------- ----------IRKPEVLRPETPRPVDIGSGGFGDVGA--LES----LRG--NADLAYILS MEPCGHCLIINNVNFC-------RESGLRTRTGSNIDCEK-LRRRFSSLHFM-VEVKGDL TAKEMVLALLELARQ-DHGALDCCVVVILSHGCQASHLQFPGA-VYGTDGCPVSVEKIVN IFNGTSCPSLGGKPKLFFIQ--ACG----GEQK-DHGFEV--AS-----TSP-EDESPGS NPEPDATPFQEGLRTF----D-Q--------------------LDA-ISSLPTPSDIFVS YSTFP--GFVSWRDPKSGSWYVETLDDIFEQWA-------HSEDLQ-----------SLL LRVSAAFLCK--------------GEGRLLRGSVSSWGWGFGVSRAGPNQG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------