10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0111838 --------MPAPPATVKPATGHTTKLNNGKSSNSNSNHTLSNSIAHLSDSRTNLTVNTPTTCQRLSEMFRRSIASSTQSSSRENTYEEWTKTLSFPSRLSPNRNSKDCSTLASPV-PPPT A_aegypti_AAEL006649-PA ---------------------------------------------------------------------------------MVRSLSQWTKTLSFPARISPNRNSKECSVNVLPITPPPA A_gambiae_AGAP010017-PA ---------------------------------------------------------------------------------MVRSLSQWTKTLSFPARISPNRNSKDCNVNVLPITPPPA X_tropicalis_ENSXETP00000056667 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000017530 ----------------------------------------------------------------------------MPGFD-YKFLEKPKRRLLCPLCGKPMREPVQVST---------- R_norvegicus_ENSRNOP00000018468 ----------------------------------------------------------------------------MPGFD-YKFLEKPKRRLLCPLCGKPMREPVQVST---------- P_troglodytes_ENSPTRP00000015252 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000009119 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000262395 ----------------------------------------------------------------------------MPGFD-YKFLEKPKRRLLCPLCGKPMREPVQVST---------- T_rubripes_ENSTRUP00000012878 ----------------------------------------------------------------------------MPGFD-YKFLEKPKRRFQCPLCSKAMREPVQVST---------- B_taurus_ENSBTAP00000050075 ----------------------------------------------------------------------------MPGFD-YKFLEKPKRRLLCPLCGKPMREPVQVST---------- B_taurus_ENSBTAP00000016271 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000009502 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000028200 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000014759 ----------------------------------------------------------------------------MPGFD-YKFLEKPKRRFQCPLCSKAMREPVQVST---------- O_latipes_ENSORLP00000005579 ----------------------------------------------------------------------------MPGFD-YKFLEKPKRRFQCPLCSKAMREPVQVST---------- M_domestica_ENSMODP00000024090 ----------------------------------------------------------------------------MPGFD-YKFLEKPKRRLLCPLCAKAMREPVQVST---------- D_rerio_ENSDARP00000013849 ----------------------------------------------------------------------------MPGFD-YKFLEKPKRRFQCPLCSKAMREPVQVST---------- D_rerio_ENSDARP00000056877 ----------------------------------------------------------------------------MPGLD-LKFLERPRRKFYCPLCEKPMREPVQVST---------- O_cuniculus_ENSOCUP00000000748 ----------------------------------------------------------------------------MPGFD-YKFLEKPKRRLLCPLCGKPMREPVKVST---------- T_nigroviridis_ENSTNIP00000019321 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000016344 ----------------------------------------------------------------------------MPGFD-YKFLEKPKRRLLCPLCGKPMREPVXXPP---------- C_intestinalis_ENSCINP00000008928 ----------------------------------------------------------------------------MPGYQ-NKFVDKVRKRHQCPLCHFPMRDPVQITA---------- C_familiaris_ENSCAFP00000027741 ----------------------------------------------------------------------------MPGFD-YKFLEKPKRRLLCPLCGKPMREPVQVST---------- O_anatinus_ENSOANP00000019424 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000003738 ----------------------------------------------------------------------------------------------CVECKYTLEFPVALSN---------- M_mulatta_ENSMMUP00000022296 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005138 -------------------PAGG-----------------------------------------------PAGFQPLHGGFRDHFVEAPEAKYCCESCRLVLCQPRQTE----------- T_rubripes_ENSTRUP00000013348 -------------------MSAGRSTDGREVQIPLQQAAPSLAMPLSVA-------------PLLTSHCVPAGFLPLHGGFRDHFVEALEAKYCCESCRLVLCQPRQTE----------- G_aculeatus_ENSGACP00000005703 ---------------------------GGRCRFPLQQVAPSLTPALSVASP--V---HRQVNPWPPSDTTPQRFLPLHKGFRDHFALTPEAKYCCETCSLVLCQPRQTE----------- B_taurus_ENSBTAP00000017918 -------------------MEPSKKL---DAAGALPANPPLKLHP--------------------ERGAGPAVLVPEQGGYKERFVKAVEDKYKCEKCRLVLCSPKQTE----------- R_norvegicus_ENSRNOP00000010906 -------------------MEPSKKM---GAAGAAQPNPPLKLQP--------------------DRGA-ASVLVPEQGGYKEKFAKTVEDKYKCEKCRLVLCNPKQTE----------- C_familiaris_ENSCAFP00000026713 -------------------MESSKKM---DSPGTLQTNPPLKLHP--------------------DRSAGTSIFVPEQGGYKERFVKTVEDKYKCEKCRLVLCNPKQTE----------- X_tropicalis_ENSXETP00000027864 -------------------MDTGKKT---DPSASV-----QKANP--------------------DRSLATTIYVPEQGGYKERFLKPVEEKYKCEKCRLVLCNPRQTE----------- D_rerio_ENSDARP00000038596 -------------------MSAGRNV---EQQIPLQQRPPSLAMP-----------------SMAQRPRPEPGFSPLHGGFRDHFVTTPEPKYCCETCRLVLCNPRQTE----------- E_caballus_ENSECAP00000011833 -------------------MESSKKM---DSPGALQTNPPLKLHP--------------------DRSTSTAVFVPEQGGYKERFVKTVEDKYKCEKCRLVLCNPKQTE----------- M_domestica_ENSMODP00000016701 -------------------MDSSKKM---DPPNPLQTV-QQKANP--------------------DRGAAVSIYVPEQGGYKEKFVKPVEDKYKCEKCHLILCNPKQTE----------- M_musculus_ENSMUSP00000021706 -------------------MESSKKM---DAAGTLQPNPPLKLQP--------------------DRGA-GSVLVPEQGGYKEKFVKTVEDKYKCEKCRLVLCNPKQTE----------- O_anatinus_ENSOANP00000023053 -------------------MDSSKKM---DPS-LVQQNVPPKGNP--------------------DRGPGASIYVPEQGGYKERFVKTVEDKYKCEKCHLILCNPKQTE----------- T_guttata_ENSTGUP00000013203 -----------------------------------------RANP--------------------DRSPSASIYVPEQGGYKEKFVNAVEDKYKCEKCHLILCNPKQTE----------- G_gallus_ENSGALP00000036699 -----------------------------------------RANP--------------------DRSPSASIYVPEQGGYKEKFVNAVEDKYKCEKCHFILCNPKQTE----------- A_carolinensis_ENSACAP00000000193 -------------------MDTSKKT---DPPVSVETV-QQKANV--------------------ERSPVPSVYIPEQGGYKEKFVNAVEDKYKCEKCRLILCNPRQTE----------- M_musculus_ENSMUSP00000082710 -------------------MAHSEEQA-AVPCAFI------------------------------RQNSGNSISLDFEPDTEYQFVEQLEERYKCAFCHSVLHNPHQTG----------- P_pygmaeus_ENSPPYP00000007003 -------------------MESSKKM---DSPGALQTNPPLKLHT--------------------DRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCRLVLCSPKQTE----------- P_troglodytes_ENSPTRP00000011503 -------------------MESSKKM---DSPGALQTNPPLKLHT--------------------DRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTE----------- H_sapiens_ENSP00000376500 -------------------MESSKKM---DSPGALQTNPPLKLHT--------------------DRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTE----------- E_caballus_ENSECAP00000005414 -------------------MAYSEEQG-GVPCGFI------------------------------RQNSSNSVSLDFEPNTEYRFVEQLEERYKCAFCHSVLHNPHQTG----------- P_troglodytes_ENSPTRP00000003288 -------------------MAYSEEHK-GMPCGFI------------------------------RQNSGNSISLDFEPNIEYQFVERLEERYKCAFCHSVLHNPHQTG----------- P_pygmaeus_ENSPPYP00000000253 -------------------MAYSEEHK-GMPCGFI------------------------------RQNSGNSISLDFEPNIEYQFVERLEERYKCAFCHSVLHNPHQTG----------- M_mulatta_ENSMMUP00000038268 -------------------MAYSEEHR-GMPCGFI------------------------------RQNSGNSISLDFEPNIEYQFVERLEERYKCAFCRSVLHNPHQTG----------- H_sapiens_ENSP00000336825 -------------------MAYSEEHK-GMPCGFI------------------------------RQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTG----------- T_guttata_ENSTGUP00000003276 -------------------MA-CDEPA-ALSGIFT------------------------------RQNSSSTSSLDFEPHADYRFVESLEERYKCAYCHLVLRNPHQTG----------- B_taurus_ENSBTAP00000015940 -------------------MAYFEEQG-GVPCGFT------------------------------RQNSGNSISLDFEPDAEYQFVERLEERYKCAFCHSVLHNPHQTG----------- D_rerio_ENSDARP00000014326 ----------------------------------------------------------------------------------------LEQQFICPSCGGIVLNPHQTG----------- C_intestinalis_ENSCINP00000003143 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000016021 -------------------MA-CDELT-GVSGIFT------------------------------RQNSASAVSLDFEPDTDYKFVETLEDRYKCAYCHSVLHNPHQTG----------- A_carolinensis_ENSACAP00000016112 -------------------MASEDLAC-QVPNFYI------------------------------RQNSTNAVSLDFEPDASYQFVEILEDRYKCTHCHLVLHNPHQTG----------- M_domestica_ENSMODP00000003305 -------------------SLTSAEYG-SASGDFL------------------------------PQNSSSYISLDFEPNIDYQFVEQLEERYKCASCHSVLHNPHQTG----------- C_intestinalis_ENSCINP00000001022 -------------------MDTAD------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000027890 -------------------M---------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000015419 -------------------MESSKKM---DSPGPLQTNPPLKLHT--------------------DRSAGTPIFAPEQGGYKEKFVKTVEDKYKCEKCRLVLCSPKQTE----------- G_gallus_ENSGALP00000002401 -------------------------------------------------------------PRAGPAGGPGADAAVLPGGSRRGVGDVPEQKYLCSNCNNVLKKALQTL----------- O_anatinus_ENSOANP00000013484 -------------------SMGSEELT-IGSRAFS------------------------------HQNSSSCISLDFEPDIQYQFVEQLEERYKCTFCHSVLHNPHQTS----------- O_cuniculus_ENSOCUP00000007884 -------------------MAYSEEPG-GIHLGFI------------------------------RQNSGSSISLDFEPNAEYRFVEQLEERYKCAFCHSVLHNPHQTG----------- G_gorilla_ENSGGOP00000004192 -------------------MESSKKM---DSPGALQTNPPLKLHT--------------------DRSAGTPVFVPEQGGYKEKXXXXXXXXXXXXXXXXXXXXXXXXX----------- C_familiaris_ENSCAFP00000017853 -------------------MAYSEDQG-GVPCGFI------------------------------RQNSSNSISLDFEPHTEYRFVEPLEERYKCALCHSVLHNPHQTG----------- T_rubripes_ENSTRUP00000047803 -----------------------------MA----------------------------------RISMDCS--SSLPGIPLSVLSVPMENKYKCQQCLQVLRKPVQAQ----------- P_troglodytes_ENSPTRP00000036949 -------------------MA--------AA----------------------------------SVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQ----------- P_pygmaeus_ENSPPYP00000022191 -------------------MA--------AA----------------------------------SVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQ----------- T_nigroviridis_ENSTNIP00000011878 -----------------------------MA----------------------------------RISLDCS--PSLPGIPLSVLSVPMENKYKCQQCLQVLRKPVQAQ----------- T_nigroviridis_ENSTNIP00000016461 -------------------MA--------AQ----------------------------------EPSPPSSMESNKPGFPKKILGNKLEDKHLCNCCHNILRRPFQAQ----------- D_rerio_ENSDARP00000069217 ----------------MISAAGTLCKWKDME----------------------------------RPSLPSSLDSTLPGISREVLSVSMEPKYQCQQCKDILRKPFQAQ----------- T_guttata_ENSTGUP00000006737 --------------------------------------------------------------------------------------DVPGHKFLCSNCNNILKKALQTL----------- O_cuniculus_ENSOCUP00000003184 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000001368 ----------------------------------------------------------------------LAGRLQTHGVVRNHFVMKLKEEFICPICKGVVLNPQQNS----------- H_sapiens_ENSP00000247668 -------------------MA--------AA----------------------------------SVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQ----------- T_nigroviridis_ENSTNIP00000013509 -------------------MA--------SQ----------------------------------EPSPPSSLEGNKPGFPRKILANNLESKHLCKSCQKVLRRPLQAQ----------- M_musculus_ENSMUSP00000109872 -------------------MA--------AA----------------------------------SVTSPGSLELLQPGFSKTLLGTRLEAKYLCSACKNILRRPFQAQ----------- M_domestica_ENSMODP00000021625 -------------------MA--------TA----------------------------------NSTPPGSLDLLQPGFSKDILGTKLEDKYLCSACKNILRRPFQAQ----------- G_aculeatus_ENSGACP00000006974 -------------------MA--------AQ----------------------------------EQSPPSSLEGNKPGFPKKILANSLEDKHLCNSCQKVLRRPLQAQ----------- O_latipes_ENSORLP00000008989 -----------------------------MA----------------------------------RISWDSL--SSLPGIPLSVLSVPMEDKYKCQQCLQVLRKPVQAQ----------- G_gallus_ENSGALP00000014649 -------------------MA--------AA----------------------------------NSTPPGSLDLSQPGFAKEILGTKLEVKYLCSDCRNILRRPFQAQ----------- O_latipes_ENSORLP00000020860 -----------------------------QQ----------------------------------EPSPPSSLEGSKPGFPRKILANCLEDKHLCNSCEKILRRPLQAQ----------- E_caballus_ENSECAP00000011150 -------------------MA--------AA----------------------------------SVTPPGSLDLLQPGFSKTLLGTKLEDKYLCSACKNVLRRPFQAQ----------- T_rubripes_ENSTRUP00000011363 -----------------------------SQ----------------------------------EPSPPSSLEGNKPGFPKKILANNLENKHLCKSCQKVLRRPLQAQ----------- B_taurus_ENSBTAP00000013869 -------------------MA--------AA----------------------------------SVTPPGSLDLLQPGFSKTLLGTKLEDKYLCSACKNVLRRPFQAQ----------- M_mulatta_ENSMMUP00000015132 -------------------MA--------AA----------------------------------SVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACGNVLRRPFQAQ----------- O_anatinus_ENSOANP00000001757 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000008559 -------------------AA--------AV----------------------------------SGSPQGSLDLNQPGFKKEILGTKLEVKYLCSDCKNLLRRPLQAQ----------- C_familiaris_ENSCAFP00000028895 -------------------MA--------AA----------------------------------SVTPPGSLDLLQPGFSKTLLGTKPEDKYLCSACRNVLRRPFQAQ----------- O_latipes_ENSORLP00000003220 -------------------MA--------AL----------------------------------EPSPPSSMESNKPGFPKKILGNKLEDKHLCNCCHNILRRPIQAQ----------- D_rerio_ENSDARP00000043465 -----------------------------AQ----------------------------------EPSPPSSLEGNKPGFPKKILANKLEDKHLCNICLKILRRPFQAQ----------- G_aculeatus_ENSGACP00000022084 -----------------------------MA----------------------------------RISLDCP--VSLPGIPLSVLSVPMENKYKCQQCLLVLRKPVQAQ----------- T_rubripes_ENSTRUP00000015632 ----------------TDAMA--------TQ----------------------------------EPSPPSSMESNKPGFPKKILGNKLEDKHLCNCCHNILRRPFQAQ----------- C_elegans_F45G2.6 ----------------------------------------------------------------------------MTSQS-VMFKGGLPADCTCPICEQALRDPIKLN----------- D_rerio_ENSDARP00000091948 --------------------SGS------------------------------------------ASDPSLNGVSSTPGFPQSICDEVPKDKYLCSNCNNVLNKARQTV----------- A_carolinensis_ENSACAP00000005007 ----------------MSLLHSNTSFETNSQESGCCAAM-ASACSAAAKEE--SINASVSNE--TGGTLSNSFMEETQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- E_caballus_ENSECAP00000009372 ----------------MASGSAS------------------------------------------SPRPAPDENEFPFGCPPTVCEDPSEPRALC------------------------- G_aculeatus_ENSGACP00000020860 -------------------MA--------TQ----------------------------------EPSPPSSMESNKPGFPKKILGNQLEDKHLCNCCHNILRRPFQAQ----------- D_rerio_ENSDARP00000036715 -------MACND-VDKSSFDDVCCD----SGHSSCA-AA-MEKERESFLSP--T---ENPSTI----SVSSSMPPDQQGYD-VEFDPPLESKYECPICLMGLRSAVQTP----------- T_guttata_ENSTGUP00000002510 -------------------MA--------AA----------------------------------NSSPPGSLDLNQPGFAKEILGTKLEVKYLCSDCKNILRRPFQAQ----------- M_domestica_ENSMODP00000024498 ----------------LTDTAPV------------------------------------------GPHLIPDENEFPFGYPASICQGTPEPKYLCCGCHNVLKKAQQTL----------- T_guttata_ENSTGUP00000010462 ----------------MSLLHSDSSCGGRDAESGCCAAM-ASACSAAAKEE--S---SSVGS--AVGTAPGSFGEETQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- O_anatinus_ENSOANP00000018657 ----------------MSLLNCENSCGASQSEGDCCAAM-ASACSAGAKDD--S---VSSSV--NTGNLHNSFMAETQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- X_tropicalis_ENSXETP00000031605 -------------------IMACEDLC-PLPVTLG------------------------------RQNSSAAVSLDFVPKQEYLFVEQLQDRYKCASCHLVLHNPHQTG----------- H_sapiens_ENSP00000316840 ----------------MSLLNCENSCGSSQSESDCCVAM-ASSCSAVTKDD--S---VGGTA--STGNLSSSFMEEIQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- P_pygmaeus_ENSPPYP00000003845 ----------------MSLLNCENSCGSSQSESDCCVAM-ASSCSAATKDD--S---VGGTA--STGNLSSSFMEEIQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- P_troglodytes_ENSPTRP00000006096 ----------------MSLLNCENSCGSSQSESDCCVAM-ASSCSAATKDD--S---VGGTA--STGNLSSSFMEEIQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- T_nigroviridis_ENSTNIP00000012472 -------MACFDSSSKGSLEEDSCDGAIGGELSGCALVM-MEKEQESLLSP--S---ESPGTYMSGASSSFHDGTHQQGYD-VEFDPPLESKYECPICLMALRNAIQTP----------- M_mulatta_ENSMMUP00000021907 MYILKERIRASDNQVTMSLLNCENSCGSSQSESDCCVAM-ASSCSAATKDD--S---VGGTA--STGNLSSSFMEDIQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- B_taurus_ENSBTAP00000021630 ----------------MSLLHCENSCGSSQSESDCCAAMAASSCGTAAKDD--S---VSGTA--STVTLSSSFMEEIQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- C_familiaris_ENSCAFP00000010159 ----------------MSLLNCENSCGSSQSESDCCPAM-ASSCSAAVKDD--S---VSGTT--STGNLSSSFMEEIQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- M_domestica_ENSMODP00000024756 ----------------MSLLNCEDSCGTSHPESDCCAGV-ASACSTGTKDD--S---VNGST--IPGNLPSSLREEIQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- R_norvegicus_ENSRNOP00000006148 ----------------MSLLNCENSCASSQSSSDCCAAM-ANSCSAAMKDD--S---VSGCV--STGNLSSSFMEEIQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- G_aculeatus_ENSGACP00000022648 -------MASAE-SGKGSLQEDSYEGPVGGELSGCALAM-MEKERESLLSP--S---ESPGTFISGSSASLQAPAPLQGYD-VEFDPPLESKYECPICLMALRNAIQTP----------- T_rubripes_ENSTRUP00000041697 -------MACFD-SSKESL-EDSFDGAAGGKLSGCALAM-SEKERESLLNP--S---ESPSTYMSGASSSFQDATHQQGYD-VEFDPPLESKYECPICLMALRNAIQTP----------- M_musculus_ENSMUSP00000004949 ----------------MSLLNCENSCGSSQSSSDCCAAM-AASCSAAVKDD--S---VSGSA--STGNLSSSFMEEIQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- G_gallus_ENSGALP00000012873 ----------------MSLLHSDSSCGGRDLDSGCCTAM-ASACSGGAKED--S---VSVGS--GTGNPPSSFTEETQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- A_carolinensis_ENSACAP00000006987 --------------------A--------SA----------------------------------NVTPPGSLDEDQVGFPKEILGTELEGKYLCSECGNILRRPFQAQ----------- X_tropicalis_ENSXETP00000016445 ----------------MSILNCRPSFDGVDTDDACCGAM-ASACCVNTKEDGES---PSAGS--PSGTPQSLVLEDVQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- E_caballus_ENSECAP00000018618 ----------------MSLLNCENSCGSSQTESDCCAAM-ASSCSAAAKDD--S---VSGTA--STGNLSSSFMEDIQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- O_cuniculus_ENSOCUP00000010330 ----------------MSLLNCENSCGSGQSESDCCAAM-ASSCSAAAKDD--S---VSGTA--STGNLSGSFVEDIQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- R_norvegicus_ENSRNOP00000058607 -------------------MA--------AA----------------------------------SVTSPGSLELLQPGFSKTLLGTRLEAKYLCSACRNILRRPFQAQ----------- M_mulatta_ENSMMUP00000021905 -------------------LNCENGCGSSQSESDYCVAM-ASSCSAATKDD--S---VGGTA--SMGNLSSSFMEEIQGYD-VEFDPPLESRYECPICLTALREAVQTP----------- O_latipes_ENSORLP00000001290 --------------------------ASGGGLSECASAM-LEKERESLPSP--S---DNPTA--SMGSSSLQAAAPLQGYD-VEFDPPLESKYECPICLMALRNAIQTR----------- C_elegans_Y110A7A.2 -----------------------------------------------------------------------------------------------------METPIMQ------------ A_gambiae_AGAP003004-PA ---------------------------------------------------------------------------FLQSAA-KADDGVLEARYECPICYCWLNEPILTK----------- 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0111838 PPRNKTTSGSGNCATSRSSSSTVSSSHS-------S-S--HSSPTPGNNNNNM----------PIT-ELEQIIYPGPDP-KHIMGSLVFCIHHKQGCKWSDELRKLK------------- A_aegypti_AAEL006649-PA PPRNKSTTST----TSSASSSTSALSHS-------S-A--TSSPSP---PPNV----------PIT-EISQIIYPDPESEKAIMGSLVFCIHHKQGCKWSDELRKLK------------- A_gambiae_AGAP010017-PA PPRNKST--S----TSSASTMSSSSSPS-------S-S--SSSPTP---PPNV----------PIT-EISQIIYPDPESEKAIMGSLVFCIHHKQGCKWSDELRKLK------------- X_tropicalis_ENSXETP00000056667 -----------------------------------S-E--GVFKCP---EDQL----------PLD-YAK--IYPDRDLETQVMGLSIRCIHSEEGCRWSGQLKQLQ------------- M_musculus_ENSMUSP00000017530 --------------CGHRFCDTCLQEFL-------S-E--GVFKCP---EDQL----------PLD-YAK--IYPDPELEVQVLGLAIRCIHSEEGCRWSGPLRHLQ------------- R_norvegicus_ENSRNOP00000018468 --------------CGHRFCDTCLQEFL-------S-E--GVFKCP---EDQL----------PLD-YAK--IYPDPELEVQVLGLAIRCIHSEEGCRWSGPLRHLQ------------- P_troglodytes_ENSPTRP00000015252 ---------------------------L-------S-E--GVFKCP---EDQL----------PLD-YAK--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ------------- P_pygmaeus_ENSPPYP00000009119 -------------------------------------E--GVFKCP---EDQL----------PLD-YAK--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ------------- H_sapiens_ENSP00000262395 --------------CGHRFCDTCLQEFL-------S-E--GVFKCP---EDQL----------PLD-YAK--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ------------- T_rubripes_ENSTRUP00000012878 --------------CGHRFCDTCLQEFL-------S-E--GVFKCP---EDQL----------PLD-YAK--IYPDPELEQQILALAIRCIHSEEGCRWTGQMKQLQ------------- B_taurus_ENSBTAP00000050075 --------------CGHRFCDTCLQEFL-------S-E--GVFKCP---EDQL----------PLD-YAK--IYPDPELEVQVLGLSIRCIHSEEGCRWNGPLRHLQ------------- B_taurus_ENSBTAP00000016271 ---------------------------------------------------------------------Q--IYPDPELEVQVLGLSIRCIHSEEGCRWNGPLRHLQ------------- E_caballus_ENSECAP00000009502 -----------------------------------S-E--GVFKCP---EDQL----------PLD-YAK--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ------------- M_mulatta_ENSMMUP00000028200 -----------------------------------S-E--GVFKCP---EDQL----------PLD-YAK--IYPDPELEVQVLGLPIRCIHSEEGCRWNGPLRHLQ------------- G_aculeatus_ENSGACP00000014759 --------------CGHRFCDTCLQEFL-------S-E--GVFKCP---EDQL----------PLD-YAK--IYPDPELEQQILALPIRCIHSEEGCRWTGQMKQLQ------------- O_latipes_ENSORLP00000005579 --------------CGHRFCDTCLQEFL-------S-E--GVFKCP---EDQL----------PLD-YAK--IYPDPELEQQILSLPIRCIHSEEGCRWTGQMKQLQ------------- M_domestica_ENSMODP00000024090 --------------CGHRFCDTCLQEFL-------S-E--GVFKCP---EDQL----------PLD-YAK--IYPDPELEAQVLSLPIRCIHSEEGCRWTGALRQLQ------------- D_rerio_ENSDARP00000013849 --------------CGHRFCDTCLQEFL-------S-E--GVFKCP---EDQL----------PLD-YAK--IYPDPELEQQILALPIRCIHSEEGCRWTGQMKQLQ------------- D_rerio_ENSDARP00000056877 --------------CGHRFCDTCLQEYL-------S-E--GVFTCP---EDQL----------PLD-YAK--IFPDLELEQQILSLPIRCIHSEEGCRWTAQNKLLQ------------- O_cuniculus_ENSOCUP00000000748 --------------CGHRFCDTC-QSFL-------X-X--XXXXXX---XXXX----------XXX-XXX--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ------------- T_nigroviridis_ENSTNIP00000019321 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000016344 --------------CGHRFCDTCLQEFL-------S-E--GVFKCP---EDQL----------PLD-YAK--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX------------- C_intestinalis_ENSCINP00000008928 --------------CRHRYCDTCLQKFL-------G-E--GVFNCP---VDHL----------SLD-YAK--IYPDPDLETEIMSLTTHCTNYSSGCKWTGKLHNLK------------- C_familiaris_ENSCAFP00000027741 --------------CGHRFCDTCLQEFL-------S-E--GVFKCP---EDQL----------PLD-YAK--IYPDPELEVQVLSLAIRCIHSEEGCRWSGPLRHLQ------------- O_anatinus_ENSOANP00000019424 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000003738 --------------CEHHACSQCVSRLW-----------KISRSCP---LDGK----------VID-RNE--VTIDEKLQIELNNLNMVCPYKHCGCHWEGMFFDFK------------- M_mulatta_ENSMMUP00000022296 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005138 --------------CGHRFCQSCITQLL-------G-H--ANPVCP---ADME----------PLF-KDK--IFRDVCCHREIMALKVYCRSEANGCQEQMRLQQIP------------- T_rubripes_ENSTRUP00000013348 --------------CGHRFCQSCINDIL-------S-H--PNPVCP---ADTE----------PLF-KDK--VFRDVCCHREIMALKVYCRSEANGCQEQMRLQQIP------------- G_aculeatus_ENSGACP00000005703 --------------CGHRFCQSCINDIL-------S-H--PNPVCP---ADME----------PLF-KDK--IFRDVCCHREIMALKVYCRSEANGCQEQMSLQQIP------------- B_taurus_ENSBTAP00000017918 --------------CGHRFCETCMGALL-------S-S--SSPKCT---ACQE----------VII-KDK--VFKDNCCKREILALQIFCRNEGRGCTEQLALGHLL------------- R_norvegicus_ENSRNOP00000010906 --------------CGHRFCESCMAALL-------S-S--SSPKCT---ACQE----------SII-KDK--VFKDNCCKREILALQIYCRNEGRGCVEQLTLGHLL------------- C_familiaris_ENSCAFP00000026713 --------------CGHRFCETCMAAVL-------S-S--SSPKCT---ACQE----------SII-KDK--VFKDNCCKREILALQIYCRNEGGGCTEQLTLGHLL------------- X_tropicalis_ENSXETP00000027864 --------------CGHRFCETCMNAIL-------S-S--TSPQCM---ACED----------NIT-KDK--VFKDNCCRREVLALQMFCRNETRGCKELITLGNLL------------- D_rerio_ENSDARP00000038596 --------------CGHRFCESCINELL-------S-K--PNPVCP---ADLL----------PLF-EDK--IFRDVCCNREIMALKVYCRSEKNGCKEQMCLQQVM------------- E_caballus_ENSECAP00000011833 --------------CGHRFCETCMAALL-------S-S--SSPKCT---ACQE----------GII-KDK--VFKDNCCKREILALQIYCRNESRGCVEQLTLGHLL------------- M_domestica_ENSMODP00000016701 --------------CGHRFCETCMHVLL-------S-A--PSPKCT---ACQE----------NII-KDK--VFKDNCCKREILALQIYCRNESRGCTEQLTLGHLL------------- M_musculus_ENSMUSP00000021706 --------------CGHRFCESCMAALL-------S-S--SSPKCT---ACQE----------SII-KDK--VFKDNCCKREILALQVYCRNEGRGCAEQLTLGHLL------------- O_anatinus_ENSOANP00000023053 --------------CGHRFCETCMNMLL-------S-S--SSPKCS---ACQE----------NVI-KDK--VFKDNCCKREILALQIYCRNENRGCTEQLTLGHLL------------- T_guttata_ENSTGUP00000013203 --------------CGHRFCETCMNALL-------R-S--SSPKCT---ACQE----------SIV-KDK--VFKDNCCRRELLALQIYCRNENKGCKEQLSLGQLL------------- G_gallus_ENSGALP00000036699 --------------CGHRFCETCMNALL-------S-T--PSPKCT---ACQE----------SIV-KDK--VFKDNCCRRELLALQIYCRNENKGCKEQLSLGQLL------------- A_carolinensis_ENSACAP00000000193 --------------CGHRYCETCMNALL-------S-C--TIPKCT---ACQE----------TIV-KEK--IFKDNCCRRELLALQIFCRNENKGCREQLTLGQLL------------- M_musculus_ENSMUSP00000082710 --------------CGHRFCQQCIRSLR-------ELN--SVPICP---VDKE----------VIK-PQE--VFKDNCCKREVLNLHVYCKN-APGCNARIILGRFQ------------- P_pygmaeus_ENSPPYP00000007003 --------------CGHRFCESCMAALL-------S-S--SSPKCT---ACQE----------SIV-KDK--VFKDNCCKREILALQIYCRNESRGCAEQLTLGHLL------------- P_troglodytes_ENSPTRP00000011503 --------------CGHRFCESCMAALL-------S-S--SSPKCT---ACQE----------SIV-KDK--VFKDNCCKREILALQIYCRNESRGCAEQLTLGHLL------------- H_sapiens_ENSP00000376500 --------------CGHRFCESCMAALL-------S-S--SSPKCT---ACQE----------SIV-KDK--VFKDNCCKREILALQIYCRNESRGCAEQLMLGHLL------------- E_caballus_ENSECAP00000005414 --------------CGHRFCQHCILSLR-------ELN--AVPLCP---VDKE----------VIK-SQE--VFKDNCCKREVLNLYVYCKN-APGCNAKIILGRYQ------------- P_troglodytes_ENSPTRP00000003288 --------------CGHRFCQHCILSLR-------ELN--TVPICP---VDKE----------VIK-SQE--VFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQ------------- P_pygmaeus_ENSPPYP00000000253 --------------CGHRFCQHCILSLR-------ELN--TVPICP---VDKE----------VIK-SQE--VFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQ------------- M_mulatta_ENSMMUP00000038268 --------------CGHRFCQHCILSLR-------ELN--TVPICP---VDKE----------VIK-SQE--VFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQ------------- H_sapiens_ENSP00000336825 --------------CGHRFCQHCILSLR-------ELN--TVPICP---VDKE----------VIK-SQE--VFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQ------------- T_guttata_ENSTGUP00000003276 --------------CGHRFCQQCILALR-------ELN--AVPTCP---VDKE----------TIK-MHE--VFKDNCCKREVLNLHVFCKN-FPDCSSKVILGRYQ------------- B_taurus_ENSBTAP00000015940 --------------CGHRFCHQCILALR-------ELD--TVPLCP---VDKE----------VIK-SQE--VFKDNCCKREVLNLYVFCKN-APRCNAKIILGRYQ------------- D_rerio_ENSDARP00000014326 --------------CGHIFCAQCVKAYT-------ENG--GSSKCP---LDSI----------PIK-PEE--IFQDNCCKRELLNLEVFCTN-APECTQRFSLCNLQ------------- C_intestinalis_ENSCINP00000003143 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000016021 --------------CGHRFCQQCILTLR-------GLN--AVPTCP---VDKE----------TIK-MHE--VFKDNCCKREVLNLYVFCKN-LPDCNSKIILGRYQ------------- A_carolinensis_ENSACAP00000016112 --------------CGHRFCQRCIASLR-------ELS--VIPTCP---VDKE----------IIK-PHE--VFKDNCCKREVLNLQVYCRN-SPACNAKTSLGRYQ------------- M_domestica_ENSMODP00000003305 --------------CGHRFCENCILSLR-------ELN--TVSICP---VDKE----------IIK-PKE--VFKDNCCKREVLNLQVFCKN-APHCAAKMILGRYQ------------- C_intestinalis_ENSCINP00000001022 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000027890 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000015419 --------------CGHRFCESCMAALL-------S-S--SSPKCT---ACQE----------SVV-RDK--VFKDNCCKREILALQIYCRNESRGCAEQLTLGHLL------------- G_gallus_ENSGALP00000002401 --------------CGHRYCSACLSWIV-------RNN--KNPVCQ---KCKEEDPSTLSEGSLLA-EER--AFGDAAINKEISELRVHCVTLG--CSWCGTMKNFE------------- O_anatinus_ENSOANP00000013484 --------------CGHRFCQHCILSLR-------ELN--NFPTCP---IDKK----------IIQ-LQE--VFKDNCCKREVLNLQVFCKN-APGCNSKMILGRYQ------------- O_cuniculus_ENSOCUP00000007884 --------------CGHRFCQHCILSLR-------ELN--TVPICP---VDKE----------VIR-SQE--VFKDNCCKREVLNLHVYCKN-APGCNAKVILGRYQ------------- G_gorilla_ENSGGOP00000004192 --------------XXXXXXXXXXXXXX-------X-X--XXXXXX---XXXX----------SIV-KDK--VFKDNCCKREILALQIYCRNESRGCAEQLTLGHLL------------- C_familiaris_ENSCAFP00000017853 --------------CGHRFCQHCILSLR-------ELN--AVPLCP---VDKE----------VIK-SQE--VFKDNCCKREVLNLYVYCKN-APGCNAKIILGRYQ------------- T_rubripes_ENSTRUP00000047803 --------------CGHRFCIHCFKELT-------S-S--GPKPCE---ACRQEE-IYEEPISVLN-SNE--VFPDNAAGREIASLPARCLNQG--CSWTGSIKQYE------------- P_troglodytes_ENSPTRP00000036949 --------------CGHRYCSFCLASIL-------S-S--GPQNCA---ACVHEG-IYEEGISILE-SSS--AFPDNAARREVESLPAVCPSDG--CTWKGTLKEYE------------- P_pygmaeus_ENSPPYP00000022191 --------------CGHRYCSFCLASIL-------S-S--GPQNCA---ACVHEG-IYEEGISILE-SSS--AFPDNAARREVESLPAVCPSDG--CTWKGTLKEYE------------- T_nigroviridis_ENSTNIP00000011878 --------------CGHRFCVHCFRELT-------S-S--GPKPCE---ACRQEE-IYEEPTSILN-SNE--VFPDNAAGREIASLPARCLNQD--CSWTGSIKQYE------------- T_nigroviridis_ENSTNIP00000016461 --------------CGHRFCSYCFTRTV-------S-N--GPQKCS---ACIKED-IFEDPTSILK-QGC--AFPDNAVRREVEHLPAVCINEN--CTWKGTIKEYE------------- D_rerio_ENSDARP00000069217 --------------CGHRFCVFCFKQLT-------S-S--GPIPCE---ACRAEG-IFEEETSVLN-IAV--AFPDNAARREIDSLPAKCPNEG--CSWSGTLKDFE------------- T_guttata_ENSTGUP00000006737 --------------CGHRYCSACLAWIL-------RNN--KNAICQ---KCKEEDPNTLGEESLLA-EER--AFGDAAINKEISELRVHCVTLG--CSWSGIMKDFE------------- O_cuniculus_ENSOCUP00000003184 -------------------------------------S--SSPKCT---ACQE----------SIV-KDK--VFKDNCCKREILALQICCRNESRGCAEQLALGHLL------------- O_latipes_ENSORLP00000001368 --------------CGHIYCFHCLQGLL-------ESSLLSGPVCP---VEKA----------AIT-PSE--VFQDNCCKREISSLEVYCTN-SPLCTSVLALNQLQ------------- H_sapiens_ENSP00000247668 --------------CGHRYCSFCLASIL-------S-S--GPQNCA---ACVHEG-IYEEGISILE-SSS--AFPDNAARREVESLPAVCPSDG--CTWKGTLKEYE------------- T_nigroviridis_ENSTNIP00000013509 --------------CGHRFCCFCFRKIV-------S-A--GPQTCR---ACISED-LFEEPASILK-SGG--AFPDNAARREVEALAAVCPNEG--CTWTGTIKEFE------------- M_musculus_ENSMUSP00000109872 --------------CGHRYCSFCLTSILRCASILSS-S--GPQNCA---ACVYEG-LYEEGISILE-SSS--AFPDNAARREVESLPAVCPNDG--CTWKGTLKEYE------------- M_domestica_ENSMODP00000021625 --------------CGHRYCSYCLTSII-------S-T--GPQNCA---ACIQEG-IYEEGISILE-SSS--AFPDNAARREVESLPAVCVNDG--CTWKGTIKEYE------------- G_aculeatus_ENSGACP00000006974 --------------CGHRFCSFCFNKIV-------S-S--GPQKCS---ACIKED-LFEDPTSILK-QGG--AFPDNAARREVEALAAVCPNEE--CTWTGTIKEFE------------- O_latipes_ENSORLP00000008989 --------------CGHRFCVHCFRQLT-------S-S--GPKPCQ---ACRKEE-IYEEPMSILN-SSE--AFPDNAAGREIASLPARCLNQG--CDWTGSIKEYE------------- G_gallus_ENSGALP00000014649 --------------CGHRYCSYCLKKII-------S-S--GPQKCA---SCIQEG-IYEEGISILE-TSS--AFPDNAARREVESLPAVCINEG--CTWKGTIKEYE------------- O_latipes_ENSORLP00000020860 --------------CGHRFCCFCFNRTV-------S-S--GPQKCS---ACIKED-LFEEPTSILK-QGG--AFHDNAARREVEALAAVCPNEG--CTWTGTVKEYE------------- E_caballus_ENSECAP00000011150 --------------CGHRYCSYCLTSIL-------S-S--GPQNCA---ACVHEG-IYEEGISILE-SSS--AFPDNAARREVESLPAVCPSDG--CTWKGTLKEYE------------- T_rubripes_ENSTRUP00000011363 --------------CGHRFCSFCFHKIV-------S-A--GPQTCS---ACISED-LFEEPASILK-LGG--AFPDNAARREVEALAAVCPNEG--CIWTGTIKEFE------------- B_taurus_ENSBTAP00000013869 --------------CGHRYCSFCLSSIL-------S-S--GPQSCA---ACVHEG-IYEEGVSILE-SSS--AFPDNAARREVESLPAVCPSEG--CSWKGTLKDYE------------- M_mulatta_ENSMMUP00000015132 --------------CGHRYCSFCLASIL-------S-S--GPQNCA---ACVHEG-IYEEGISILE-SSS--AFPDNAARREVESLPAVCPIDG--CTWKGTLKEYEVKMPVCGTVTEPA O_anatinus_ENSOANP00000001757 ------------------------------------------------------------------------AFSDAAINKEISELNVHCVTPG--CSWTGLMKNFE------------- X_tropicalis_ENSXETP00000008559 --------------CGHRYCSHCLNKII-------S-T--GPQKCS---ACIQEG-IWHQTVCIVS-DWG--GQPGNV--RGVGGGSSVILGGGMYCVLNPTHQSGR------------- C_familiaris_ENSCAFP00000028895 --------------CGHRYCSYCLSSIL-------S-S--GPQNCA---ACVHEG-IYEEGISILE-SSS--AFPDNAARREVESLPAVCPNNG--CTWKGTLKEYE------------- O_latipes_ENSORLP00000003220 --------------CGHRFCSYCFNRTV-------S-N--GPQKCN---ACIKEE-IFEEPTSILK-QGC--AFPDNAVRREVEGLSADCINEN--CPWKGTIKEYE------------- D_rerio_ENSDARP00000043465 --------------CGHRFCSYCFNKAV-------S-K--DKKVCT---TVV----------IMKK-KKK--AFPDNAAKREVEALEAVCINEE--CSWTGTIKEYE------------- G_aculeatus_ENSGACP00000022084 --------------CGHRFCVHCFRQLT-------S-Y--GPKPCD---ACRQEE-IYEEPISILN-SNE--AFPDNAAGREIASLPAKCLNQG--CDWTGSIKEYE------------- T_rubripes_ENSTRUP00000015632 --------------CGHRFCSYCFNRTV-------S-N--GPQKCS---ACIKRI-LWFQ------------AFPDNAVRREVEHLPAACINEN--CTWKGTIKEYE------------- C_elegans_F45G2.6 --------------CDHHYCRQCFENEN------------RTPGCA---ACQT----------IIQ-PEL--CQHDRAKQKQILALPVVCTFESSGCPWDGQLGTLH------------- D_rerio_ENSDARP00000091948 --------------CGHRYCLACVNWLV-------RNN--KDLVCT---KCKGEDSNVESDTSVLT-PNQ--FFNDVAINKEILDLKVHCANQG--CPWRSTLKNFE------------- A_carolinensis_ENSACAP00000005007 --------------CGHRFCKACIVKSI----------RDAGHKCP---IDNE----------ILL-ETQ--LFPDNFAKREILSLTVKCPNKG--CDQKMELRHLE------------- E_caballus_ENSECAP00000009372 -------------------CAACLSENS-------RNG--EDRVCL---KCRGDDSQSVGPGSLVS-QEK--VHSD-------------------------------------------- G_aculeatus_ENSGACP00000020860 --------------CGHRFCSYCFNRTV-------S-N--GPQKCS---ACIKED-LFEDPTSILK-PGC--AFPDNAVRREVENLSAVCIHEH--CSWKGSIKDYE------------- D_rerio_ENSDARP00000036715 --------------CGHRFCDSCIRKSI----------RDTGQKCP---VDNE----------VLL-EEQ--LFPDNFAKREILSLTVKCSNFG--CSEKMELRQLE------------- T_guttata_ENSTGUP00000002510 --------------CGHRYCSYCLKKII-------S-A--GPQKCA---SCIQEG-IYEEGISILE-TSS--AFPDNAARREVESLPAVCINSG--CNWKGTIKEYE------------- M_domestica_ENSMODP00000024498 --------------CGHRYCAACLSWIL----------------------------SSPNDGTLFF-WGF--FQNS-------------------------------------------- T_guttata_ENSTGUP00000010462 --------------CGHRFCKGCIVKSI----------RDAGHKCP---VDNE----------ILL-ENQ--LFPDNFAKREILSLMVKCPNKG--CSMKMELRHLE------------- O_anatinus_ENSOANP00000018657 --------------CGHRFCKACIVKSI----------RDAGHKCP---VDNE----------ILL-ENQ--LFPDNFAKREILSLMVRCPNEG--CLMKMELRQLE------------- X_tropicalis_ENSXETP00000031605 --------------CGHRFCEKCISNLI-------ELS--ETPQCP---IDME----------NIK-SHE--IFKDNCCKREVLNLLVYCKN-SPACDVKVMLGRYQ------------- H_sapiens_ENSP00000316840 --------------CGHRFCKACIIKSI----------RDAGHKCP---VDNE----------ILL-ENQ--LFPDNFAKREILSLMVKCPNEG--CLHKMELRHLE------------- P_pygmaeus_ENSPPYP00000003845 --------------CGHRFCKACIIKSI----------RDAGHKCP---VDNE----------ILL-ENQ--LFPDNFAKREILSLMVKCPNEG--CLHKMELRHLE------------- P_troglodytes_ENSPTRP00000006096 --------------CGHRFCKACIIKSI----------RDAGHKCP---VDNE----------ILL-ENQ--LFPDNFAKREILSLMVKCPNEG--CLHKMELRHLE------------- T_nigroviridis_ENSTNIP00000012472 --------------CGHRFCKNCIEKSI----------RDAGQRCP---VDNE----------MLS-KEQ--LFPDNFAKREILSLIVRCSNPG--CTSKMELRHLE------------- M_mulatta_ENSMMUP00000021907 --------------CGHRFCKACIIKSI----------RDAGHKCP---VDNE----------ILL-ENQ--LFPDNFAKREILSLMVKCPNEG--CLHKMELRHLE------------- B_taurus_ENSBTAP00000021630 --------------CGHRFCKACIIKSI----------RDAGHKCP---VDNE----------ILL-ENQ--LFPDNFAKREILSLMVKCPNEG--CLHKMELRHLE------------- C_familiaris_ENSCAFP00000010159 --------------CGHRFCKACIIKSI----------RDAGHKCP---VDNE----------ILL-ENQ--LFPDNFAKREILSLMVKCPNEG--CLHKMELRHLE------------- M_domestica_ENSMODP00000024756 --------------CGHRFCKACIVKSI----------RDAGHKCP---VDNA----------ILL-ETQ--LFPDNFAKREILSLTVKCPNEG--CLLKMELRHLE------------- R_norvegicus_ENSRNOP00000006148 --------------CGHRFCKACITKSI----------RDAGHKCP---VDNE----------ILL-ENQ--LFPDNFAKREILSLTVKCPNKG--CVQKMELRHLE------------- G_aculeatus_ENSGACP00000022648 --------------CGHRFCKNCIEKSI----------RDTGQRCP---VDNE----------RLL-EDQ--LFPDNFAKREILSLTVRCPNSD--CADKMELRHLE------------- T_rubripes_ENSTRUP00000041697 --------------CGHRFCKICIEKSI----------RDAGQRCP---VDNE----------MLS-KEQ--LFPDNFAKREILSLTVRCSNPG--CTGKMELRHLE------------- M_musculus_ENSMUSP00000004949 --------------CGHRFCKACIIKSI----------RDAGHKCP---VDNE----------ILL-ENQ--LFPDNFAKREILSLTVKCPNKG--CLQKMELRHLE------------- G_gallus_ENSGALP00000012873 --------------CGHRFCKGCIVKSI-------RRCRDAGHKCP---VDNE----------ILL-ENQ--LFPDNFAKREILSLTVKCPNKG--CCLKMELRHLE------------- A_carolinensis_ENSACAP00000006987 --------------CGHRYCASCLQRLI-------S-S--GPQKCG---ACIQEG-IYEDGVSILE-TGS--AFPDNAARREVESLPAICANEG--CAWKGTIKEYE------------- X_tropicalis_ENSXETP00000016445 --------------CGHRFCKACILKSI----------RDAGHKCP---VDNE----------SLM-ENQ--LFPDNFAKREILSLRVKCPSQG--CTETMELRHLE------------- E_caballus_ENSECAP00000018618 --------------CGHRFCKACIIKSI----------RDAGHKCP---PD-E----------ILY-HP-----ASSLTRRESL-LCPMCPHCM--CYPPSKLYHRS------------- O_cuniculus_ENSOCUP00000010330 --------------CGHRFCKACIIKSI----------RDAGHKCP---VDNE----------ILL-ENQ--LFPDNFAKREILSLTVKCPNEG--CLHKMELRHLE------------- R_norvegicus_ENSRNOP00000058607 --------------CGHRYCSFCLTSILRSQSAHSS-S--GPQNCA---ACVHEG-LYEEGISILE-SSS--AFPDNAARREVESLPAVCPNDG--CTWKGTLKEYE------------- M_mulatta_ENSMMUP00000021905 --------------CGHRFRKGCIIKSI----------RDAGHKCP---VDDE----------ILL-ENK--LFPDSFAKREILSLMVNCPNEG--CLHKMELRHLG------------- O_latipes_ENSORLP00000001290 --------------CGHRFCKSCIEKSI----------RDTGQRCP---VDNE----------MLS-EDQ--LFPDNFAKREILSLTVRCPNSD--CGEKMELRHLE------------- C_elegans_Y110A7A.2 ----------------------------------------------------------------------------EGVEKEITPRPIMVQPMG-------GMKPIK------------- A_gambiae_AGAP003004-PA --------------CGHRFCRKCITDWL----------NEKNSNCP---LDNE----------PLDIKCD--IFPDNCTRREISQIKKPCPNSMRGCGEQLSPTDID------------- 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0111838 --------------------------------------GH--L-NACKHD-ATQCPN------KCGAQIPRIMMTD----HLQYTCTMRRTRCEFCQSEFSGAGL-E--EHNGSCGQEPV A_aegypti_AAEL006649-PA --------------------------------------AH--L-NTCKHD-AIQCPN------KCGSQIPRVMMTD----HLAFTCILRRAICEFCNVEFTGIGL-E--EHAGTCSSEPI A_gambiae_AGAP010017-PA --------------------------------------AH--L-NTCKHD-AIQCPN------KCGSQIPRVMMTD----HLAFTCILRRAICEFCNVEFTGIGL-E--EHAGTCSSEPI X_tropicalis_ENSXETP00000056667 --------------------------------------PH--L-NICAFN-VIPCPN------RCSTKLIRRDLPE----HMQHDCPKRKVRCEFCGADFTGEAY-E--DHQGCCPQESV M_musculus_ENSMUSP00000017530 --------------------------------------GH--L-NTCSFN-VVPCPN------RCPAKLSRRDLPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SHEGVCPQESV R_norvegicus_ENSRNOP00000018468 --------------------------------------GH--L-NTCSFN-VVPCPN------RCPAKLSRRDLPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SHEGVCPQESV P_troglodytes_ENSPTRP00000015252 --------------------------------------GH--L-NTCSFN-VIPCPN------RCPMKLSRRDLPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SHEGMCPQESV P_pygmaeus_ENSPPYP00000009119 --------------------------------------GH--L-NTCSFN-VIPCPN------RCPMKLSRRDLPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SHEGMCPQESV H_sapiens_ENSP00000262395 --------------------------------------GH--L-NTCSFN-VIPCPN------RCPMKLSRRDLPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SHEGMCPQESV T_rubripes_ENSTRUP00000012878 --------------------------------------GH--F-STCAFN-VIPCPN------RCSVKLTRRDLPD----HLQHDCPKRKVKCEFCGSEFTGEAY-E--NHQGVCPQESV B_taurus_ENSBTAP00000050075 --------------------------------------GH--L-NTCSFN-VVPCPN------RCPAKLSRRDLPA----HLQHDCPKRRLKCEFCGCDFSGEAF-E--SHEGVCPQESV B_taurus_ENSBTAP00000016271 --------------------------------------GH--L-NTCSFN-VVPCPN------RCPAKLSRRDLPA----HLQHDCPKRRLKCEFCGCDFSGEAF-E--SHEGVCPQESV E_caballus_ENSECAP00000009502 --------------------------------------GH--L-NTCSFN-VVPCPN------RCPTKLSRRDLPA----HLQHDCPKRRLKCEFCGCDFSGEAF-E--SHEGMCPQESV M_mulatta_ENSMMUP00000028200 --------------------------------------GH--L-NTCSFN-VVPCPN------RCPMKLSRRDLPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SHEGMCPQESV G_aculeatus_ENSGACP00000014759 --------------------------------------GH--F-STCAFN-VIPCPN------RCSVKLTRRDLPD----HLQHDCPKRKVKCEFCGSEFTGEAY-E--NHQGVCPQESV O_latipes_ENSORLP00000005579 --------------------------------------GH--F-STCAFN-VIPCPN------RCSVKLTRRDLPD----HLQHDCPKRKVKCEFCGSEFTGEAF-E--NHQGVCPQESV M_domestica_ENSMODP00000024090 --------------------------------------VH--L-SSCGYN-VVACPN------RCNGKLSRRDLPS----HLQHECPKRRLKCDFCGIDFTGEAF-E--SHEGVCPQESV D_rerio_ENSDARP00000013849 --------------------------------------SH--F-STCAFN-VIPCPN------RCSVKLTRRDLPE----HLQHDCPKRKVKCEFCGSEFTGEAY-E--NHQGICPQESV D_rerio_ENSDARP00000056877 --------------------------------------AH--L-SVCEFN-VVSCPN------RCSVKLLRRELPE----HLQHDCAKRKLHCDHCGEQFTGEAY-E--NHQGVCPEESV O_cuniculus_ENSOCUP00000000748 --------------------------------------GH--L-NTCSFN-VVACPN------RCPAKLSRRDLPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SHEGMCPQESV T_nigroviridis_ENSTNIP00000019321 ------------------------------------------------------------------VKLTRRDLPD----HLQHDCPKRKVKCEFCGSEFTGEAY-E--NHQGVCPQESV G_gorilla_ENSGGOP00000016344 --------------------------------------XX--X-XXXXXX-XXXXXX------RCPMKLSRRDLPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SHEGMCPQESV C_intestinalis_ENSCINP00000008928 --------------------------------------AH--M-DKCSHS-ERDCPN------RCGVRIRSMKLAD----HLEYECMKRRVACDFCGKEFTGEMM-D--EHEGACPQESV C_familiaris_ENSCAFP00000027741 --------------------------------------SH--L-NTCSFN-VIPCPN------RCPTKLSRRDLPA----HLQHDCPKRRLKCEFCGCDFSGEAF-E--SHEGVCPQESV O_anatinus_ENSOANP00000019424 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000003738 --------------------------------------SH--Y-DECLYT-EEVCSN------DCGFRCSKHLMDN----HLQIECSKRLVVCEFCALHLKAENE-I--EHL-------- M_mulatta_ENSMMUP00000022296 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005138 --------------------------------------DH--L-NVCPFF-EVPCPLG-----KCKERMMRKEIPD----HLSWKCKFRESSCEFCMTKMPLTEL-Q--KHK-------- T_rubripes_ENSTRUP00000013348 --------------------------------------DH--L-NTCPFF-EVPCPLG-----KCKERMMRKEIPE----HLSWKCKYRETSCEFCMTKMPLTEL-Q--KHK-------- G_aculeatus_ENSGACP00000005703 --------------------------------------DH--L-NVCPFF-EVPCPLG-----KCKERMMRKEIPD----HLSWKCKHRETSCEFCMTKMPLTDL-Q--KHK-------- B_taurus_ENSBTAP00000017918 --------------------------------------VH--LKNDCQFE-ELPCVRA-----DCKEKVLRKDLRD----HVEKACKYREATCSHCKSQVPMVTL-Q--KHE-------- R_norvegicus_ENSRNOP00000010906 --------------------------------------VH--LKNECQFE-ELPCLRA-----DCKEKVLRRDLRD----HVEKACKYREATCAHCKSQVPMITL-Q--KHE-------- C_familiaris_ENSCAFP00000026713 --------------------------------------VH--LKNDCQFE-ELSCVRA-----DCKEKVLRRDLRD----HVEKACKYREATCPHCKSQVPMITL-Q--KHE-------- X_tropicalis_ENSXETP00000027864 --------------------------------------IH--LKSDCQFE-ELSCPRA-----DCKEKVIRKDLSD----HIEKTCKYRETPCKFCRNQVPLVEM-Q--KHE-------- D_rerio_ENSDARP00000038596 --------------------------------------EH--L-VICPYF-EVPCPLG-----KCKEKMMRKDMPE----HLSRKCKHREVTCEFCSLKMALTEL-Q--KHK-------- E_caballus_ENSECAP00000011833 --------------------------------------VH--LKNDCQFE-ELACVRP-----DCKEKVLRKDLRD----HVEKACKYREATCSHCKSQVPMITL-Q--KHE-------- M_domestica_ENSMODP00000016701 --------------------------------------VH--LKSECQFE-ELPCVRA-----DCKEKILRKDLQD----HVEKSCKYREATCQYCKSQVPMITL-Q--KHE-------- M_musculus_ENSMUSP00000021706 --------------------------------------VH--LKNECQFE-ELPCLRA-----DCKEKVLRKDLRD----HVEKACKYREATCSHCKSQVPMIKL-Q--KHE-------- O_anatinus_ENSOANP00000023053 --------------------------------------VH--LKSDCQFE-ELSCPRA-----DCKEKVLRKDLPD----HIEKSCKYREATCKYCTSQVPMITL-Q--KHE-------- T_guttata_ENSTGUP00000013203 --------------------------------------MH--LRTDCQFE-ELPCPRA-----DCKEKILRKDLPD----HVEKTCKYRETTCKYCKSQVPMIML-Q--KHE-------- G_gallus_ENSGALP00000036699 --------------------------------------MH--LKTDCQFE-ELPCPRA-----DCKEKILRKDLPD----HVEKTCKYRETTCKYCKSQVPMIML-Q--KHE-------- A_carolinensis_ENSACAP00000000193 --------------------------------------TH--LRNDCLFE-ELPCPRV-----DCKEKILRKDLPD----HAEKTCKYRETTCKYCKSQVPIIMI-Q--KHE-------- M_musculus_ENSMUSP00000082710 --------------------------------------DH--L-QHCSFQ-AVPCPNE-----SCREAMLRKDVKE----HLSAYCRFREEKCLYCKRDIVVTNL-Q--DHE-------- P_pygmaeus_ENSPPYP00000007003 --------------------------------------VH--LKNDCHFE-ELPCVRP-----DCKEKVLRKDLRD----HVEKACKYREATCSHCKSQVPMIAL-Q--KHE-------- P_troglodytes_ENSPTRP00000011503 --------------------------------------VH--LKNDCHFE-ELPCVRP-----DCKEKVLRKDLRD----HVEKACKYREATCSHCKSQVPMIAL-Q--KHE-------- H_sapiens_ENSP00000376500 --------------------------------------VH--LKNDCHFE-ELPCVRP-----DCKEKVLRKDLRD----HVEKACKYREATCSHCKSQVPMIAL-Q--KHE-------- E_caballus_ENSECAP00000005414 --------------------------------------DH--L-QQCLFQ-AVQCSNE-----HCQESVLRKNLKE----HLSAYCQFREEKCLYCKKDVVVINL-Q--NHE-------- P_troglodytes_ENSPTRP00000003288 --------------------------------------DH--L-QQCLFQ-AVQCSNE-----KCREPVLRKDLKE----HLSAYCQFREEKCLYCKKDVVVINL-Q--NHE-------- P_pygmaeus_ENSPPYP00000000253 --------------------------------------DH--L-QQCLFQ-AVQCSNE-----KCREPVLRKDLKE----HLSAYCQFREEKCLYCKKDVVVINL-Q--NHE-------- M_mulatta_ENSMMUP00000038268 --------------------------------------DH--L-QQCLFQ-AVQCSNE-----NCQEPVLRKDLKE----HLSAYCQFREEKCLYCKKDVVVINL-Q--NHE-------- H_sapiens_ENSP00000336825 --------------------------------------DH--L-QQCLFQ-PVQCSNE-----KCREPVLRKDLKE----HLSASCQFRKEKCLYCKKDVVVINL-Q--NHE-------- T_guttata_ENSTGUP00000003276 --------------------------------------EH--L-QQCLFE-CTQCTND-----GCRDRVLRKDLKE----HLRQQCKFREERCQYCNTYVVFINI-E--NHE-------- B_taurus_ENSBTAP00000015940 --------------------------------------DH--L-QHCLFQ-PVQCSNE-----NCREPVLRKDLKE----HLSAYCQFREEKCLYCKKDVVVINL-Q--NHE-------- D_rerio_ENSDARP00000014326 --------------------------------------DH--L-KACPHE-RVRCSHS-----DCSDIVLRKNLLE----HQRNACSYRLETCHYCRQNFPVSQMMQ--GHQ-------- C_intestinalis_ENSCINP00000003143 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000016021 --------------------------------------EH--L-QQCLFE-SVQCTND-----GCCDQILRKDLKD----HLSQHCKFREEMCQYCNKYVVLINI-K--NHE-------- A_carolinensis_ENSACAP00000016112 --------------------------------------DH--L-QQCLFE-SVQCTNE-----GCCEKVLQKDLKE----HLGLHCNYRKELCRYCNQPVTSINV-K--THE-------- M_domestica_ENSMODP00000003305 --------------------------------------DH--L-LQCLFQ-SVQCSNE-----CCQERILRKDLKN----HLELHCQFREEMCPFCNKDVVIIDL-Q--NHK-------- C_intestinalis_ENSCINP00000001022 ----------------------------------------------------------------------------------------------------------S--RHQ-------- C_intestinalis_ENSCINP00000027890 ---------------------------------------------------------------------------------------------------------------L-------- M_mulatta_ENSMMUP00000015419 --------------------------------------VH--LKNDCHFE-ELPCVRA-----DCKEKVLRKDLRD----HVEKACKYREATCSHCKSQVPMIAL-Q--KHE-------- G_gallus_ENSGALP00000002401 --------------------------------------EH--Q-ILCEYA-LIPCHT------GCGHVVMRKKLAD----HLENGCVNNVTVCHKCKQSLSSSEY-Q--P---------- O_anatinus_ENSOANP00000013484 --------------------------------------DH--L-QQCLFQ-PVQCSNE-----SCQEKVLRKDMKD----HLGCHCKFREEKCQYCQKYVVAIDL-Q--NHE-------- O_cuniculus_ENSOCUP00000007884 --------------------------------------EH--L-QQCLFQ-VVQCSHD-----SCQEPVLRRDLNE----HLSAYCQFREEKCLYCKKDVVVMDL-Q--NHE-------- G_gorilla_ENSGGOP00000004192 --------------------------------------XX--XXXXXXXX-XXXXXXX-----XXXXXXXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXX-X--KHE-------- C_familiaris_ENSCAFP00000017853 --------------------------------------QYIWL-QYSTPR-AKVRVNRRSIGTSCKHTMCRGSEGE----LLSHETALPGSSILLGKQEACILSLSQ--NHE-------- T_rubripes_ENSTRUP00000047803 -------------------------------------AQH--E-GRCELE-QIKCD-------ACQASVLRAEIDR----HNERECEARTLNCKYCKLTFHFKDI-K--AHD-------- P_troglodytes_ENSPTRP00000036949 -------------------------------------SCH--E-GRCPLM-LTECP-------ACKGLVRLGEKER----HLEHECPERSLSCRHCRAPCCGADV-K--AHH-------- P_pygmaeus_ENSPPYP00000022191 -------------------------------------SCH--E-GRCPLM-LTECP-------ACKGLVRLGEKER----HLEHECPERSLSCRHCRAPCCGADV-K--AHH-------- T_nigroviridis_ENSTNIP00000011878 -------------------------------------AQH--E-GRCEFE-QIKCD-------ACQAFVLRAEKDR----HNERECEARTLNCKYCKFTFHFKDI-K--AHD-------- T_nigroviridis_ENSTNIP00000016461 -------------------------------------LSH--E-GKCEFM-IISCP-------SCKEHIRFNEQER----HNERECPERTLNCKYCKEPFHFKNI-K--AHD-------- D_rerio_ENSDARP00000069217 -------------------------------------NQH--E-GRCAFE-RVKCE-------ACQVLILLSEKDR----HNERECEARTLNCKYCKVTFNFKEI-K--AHD-------- T_guttata_ENSTGUP00000006737 --------------------------------------EH--Q-SLCEYA-LIPCHT------GCGHVVMRRKLAD----HLENGCVNNVTVCQQCQCSLATSEC-Q--V---------- O_cuniculus_ENSOCUP00000003184 --------------------------------------VH--LKNDCQFE-ELACVRA-----DCKEKVLRKDLRD----HVEKACKYREATCSHCKSQVPMITL-Q--XXX-------- O_latipes_ENSORLP00000001368 --------------------------------------EH--L-KSCQYE-QLLCSNP-----GCTELLQRRLLQE----HLNATCPHRRESCPHCLQPFQLSVI-Q--DHV-------- H_sapiens_ENSP00000247668 -------------------------------------SCH--E-GRCPLM-LTECP-------ACKGLVRLGEKER----HLEHECPERSLSCRHCRAPCCGADV-K--AHH-------- T_nigroviridis_ENSTNIP00000013509 -------------------------------------ARH--E-DSCDFM-IILCP-------SCKELMRANEQER----HNERECPERTLNCKYCKEAFQLKSI-K--AHD-------- M_musculus_ENSMUSP00000109872 -------------------------------------SCH--E-GLCPFL-LTECP-------ACKGLVRLSEKEH----HTEQECPKRSLSCQHCRAPCSHVDL-E--VHY-------- M_domestica_ENSMODP00000021625 -------------------------------------SCH--E-GHCSFM-LIECP-------ACKWMIKLGEKEH----HSERECPKRSLNCRYCKALFYYPDI-K--AHD-------- G_aculeatus_ENSGACP00000006974 -------------------------------------ASH--E-DNCDFM-IIMCP-------SCKELMRANEQER----HNERECPERTLNCRYCKEPFLLKNI-K--AHD-------- O_latipes_ENSORLP00000008989 -------------------------------------AKH--E-GRCEFE-QIQCE-------ACQALVLRKDKDR----HNDRECEERTLNCKYCKVTFNFKDI-K--AHD-------- G_gallus_ENSGALP00000014649 -------------------------------------SCH--E-GNCPFL-LIECQ-------ACRGVIPLNEKER----HSERECPERTLNCKYCKSLFYFPDI-K--AHD-------- O_latipes_ENSORLP00000020860 -------------------------------------ASH--E-GSCDFT-IIMCP-------SCKELMRANEQER----HNERECPERTLNCKYCKEPFLLKNI-K--AHD-------- E_caballus_ENSECAP00000011150 -------------------------------------SCH--E-GHCPFM-LTECP-------ACKGLVRLGEKEH----HLEHECPERSLSCRHCRAPCCWADM-K--AHH-------- T_rubripes_ENSTRUP00000011363 -------------------------------------ARH--E-DSCDFM-IILCP-------SCKELMRVNEQER----HNERECPERTLNCKYCKDPFQLKNI-K--AHD-------- B_taurus_ENSBTAP00000013869 -------------------------------------SCH--E-GQCPFM-LTECP-------ACKGLVRLGEKEH----HLEHQCPERSLSCRHCRAPCSPADM-K--AHH-------- M_mulatta_ENSMMUP00000015132 VGSRPRSPSGRDLVLHVLTGAEACLMSVEEETELLLRSCH--E-GRCPLM-LTECP-------ACKGLVRLGEKER----HLEHECPERSLSCRHCRAPCCGADG-K--AHH-------- O_anatinus_ENSOANP00000001757 ------------------------------------PQDH--Q-AECDCA-LIPCHA------GCGLMIMRKKLPD----HLENGCAKSPTTCLKCKQTFCSMEY--------------- X_tropicalis_ENSXETP00000008559 -------------------------------------YCY--S-LGTCTA-LTHCV-------LCPGYPWNYSGDL----HSERECPERKLNCRYCKLSFYFPDI-K--AHD-------- C_familiaris_ENSCAFP00000028895 -------------------------------------SCH--E-GHCPFM-LTECP-------ACKGLVRLGEKEH----HSEHECPERSLSCRHCRAPCCWADL-K--AHH-------- O_latipes_ENSORLP00000003220 -------------------------------------LDH--E-GKCEFM-IIPCP-------SCKERIRFSEQER----HSERECPERTLNCKYCKEPFHFKNI-K--AHD-------- D_rerio_ENSDARP00000043465 -------------------------------------ANH--E-GKCDFR-ILPCP-------SCKELLRANELER----HNERECPERTLNCKYCKEPFHFKNI-K--AHD-------- G_aculeatus_ENSGACP00000022084 -------------------------------------AQH--E-GRCELE-RMQCE-------ACKMSVLCTDKDR----HNERECEERTLNCKYCKMTFNFKEI-K--AHD-------- T_rubripes_ENSTRUP00000015632 -------------------------------------LNH--E-GKCEFM-IISCP-------SCKEHIRFNEQER----HNERECPERTLNCKYCKEPFHFKNI-K--AHD-------- C_elegans_F45G2.6 --------------------------------------DH--L-SECTFKSSLKCE-------KCGRQFAKNDLEK----H-RAKCELNRAVCSFCNKTIRDSDR-E--RHP-------- D_rerio_ENSDARP00000091948 -------------------------------------QDH--Q-SQCEYA-LIPCNI------GCGIMVQRKTLAT----HLESGCPNNKTACPSCTSVLTPREL-Q--V---------- A_carolinensis_ENSACAP00000005007 --------------------------------------DH--Q-QHCGFA-SEKCP-------QCQGIFQKNRLQE----HIKLECPRRQVSCPNCALLMPYEDK-E--VHD-------- E_caballus_ENSECAP00000009372 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000020860 -------------------------------------LTH--E-GKCEFM-IIPCP-------SCKERIRFNEQER----HNERECPERTLNCKYCKEPFHFKNI-K--AHD-------- D_rerio_ENSDARP00000036715 --------------------------------------KH--L-SQCRFA-TAPCP-------QCQESVPISHLDE----HKSQHCLQRIMTCPDCAGSFVYAVK-Q--NHE-------- T_guttata_ENSTGUP00000002510 -------------------------------------VQA--K-ARLGTS-ASFFP-------LC-----LGKAQRVVCAHVGESCQIPGLYCQLEKFP-NVVHM-V--LHC-------- M_domestica_ENSMODP00000024498 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000010462 --------------------------------------DH--Q-LQCDFS-TVECL-------QCQGTFPKNHLKE----HMTQECPRRQVCCPNCATSMAYEDK-E--LHD-------- O_anatinus_ENSOANP00000018657 --------------------------------------EH--Q-SLCDYA-LVECP-------QCHISFQKNILHD----HVVSECPRRQVSCVNCALSMAFEDK-E--YHD-------- X_tropicalis_ENSXETP00000031605 --------------------------------------EH--L-GQCLYE-MTLCSND-----GCHDQMIRKELKG----HLESECKLRQEACIYCKQTMASINL-T--IHV-------- H_sapiens_ENSP00000316840 --------------------------------------DH--Q-AHCEFA-LMDCP-------QCQRPFQKFHINI----HILKDCPRRQVSCDNCAASMAFEDK-E--IHD-------- P_pygmaeus_ENSPPYP00000003845 --------------------------------------DH--Q-AHCEFA-LMDCP-------QCQRPFQKFHINI----HILKDCPRRQVSCDNCAASMAFEDK-E--IHD-------- P_troglodytes_ENSPTRP00000006096 --------------------------------------DH--Q-AHCEFA-LMDCP-------QCQRPFQKFHINI----HILKDCPRRQVSCDNCAASMAFEDK-E--IHD-------- T_nigroviridis_ENSTNIP00000012472 --------------------------------------NH--L-ASCEFA-TVPCP-------HCQQSVKKTLLEE----HTSVQCRRRPVSCPDCVEIFVYEEK-E--RHE-------- M_mulatta_ENSMMUP00000021907 --------------------------------------DH--Q-AHCEFA-LVDCP-------QCQRPFQKFHINI----HILKDCPRRQVSCDNCAALVAFEDK-E--IHD-------- B_taurus_ENSBTAP00000021630 --------------------------------------EH--Q-AHCEFA-LMSCP-------QCQRPFQKCHLNI----HILKECPRRQVPCENCAVSMAFEDK-E--IHE-------- C_familiaris_ENSCAFP00000010159 --------------------------------------DH--Q-LHCEFA-LMNCL-------QCQRTFQKCQLNI----HILKECPRRQVSCMNCAALMAFEDK-E--IHD-------- M_domestica_ENSMODP00000024756 --------------------------------------DH--Q-THCEFA-LAECP-------QCHLPFRKYLLHN----HMVVECPRRQVSCVNCAAPMPFEEK-EAKFHD-------- R_norvegicus_ENSRNOP00000006148 --------------------------------------DH--Q-VHCEFA-LVICP-------QCQRFFQKCQINK----HIIEDCPRRQVSCVNCAVPMPYEEK-E--IHD-------- G_aculeatus_ENSGACP00000022648 --------------------------------------NH--L-GRCQFA-TVPCS-------QCQQAVRKSRLEE----HQTAECQKRPVSCPDCVASFFYEER-K--LHQ-------- T_rubripes_ENSTRUP00000041697 --------------------------------------DH--L-AHCQFA-TVPCP-------HCQQSVRKTILEE----HMTAECRRRPVSCPDCIETFVYEER-E--RHE-------- M_musculus_ENSMUSP00000004949 --------------------------------------DH--Q-VHCEFA-LVNCP-------QCQRPFQKCQVNT----HIIEDCPRRQVSCVNCAVSMAYEEK-E--IHD-------- G_gallus_ENSGALP00000012873 --------------------------------------EH--Q-LHCDFT-TVECP-------QCQGAFQKNHLKE----HMTQECPRRQVCCPNCATSMAYEDK-E--LHD-------- A_carolinensis_ENSACAP00000006987 -------------------------------------SGH--G-GSCPWA-LATCP-------SCRGPVRRRDQER----HAARECPQRSLSCKFCKALCHFPQI-K--AHD-------- X_tropicalis_ENSXETP00000016445 --------------------------------------RH--L-VRCDFA-GVECS-------QCQSSFPKYSLQK----HMFEECPRRQIFCENCALAMALEDK-L--NHD-------- E_caballus_ENSECAP00000018618 --------------------------------------DH--Q-AHCEFA-LMNCP-------QCQHPFQKCQLNI----HMLKECPRRQVSCVNCAVSMAFEDK-EASIHD-------- O_cuniculus_ENSOCUP00000010330 ------------------------------------XXXX--X-XXXXXX-XXXXX-------XXXXXXXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXX-X--IHD-------- R_norvegicus_ENSRNOP00000058607 -------------------------------------SCH--E-GLCPFL-LTECP-------ACKGLVRLSEKKH----HTEQECPKRSLSCQHCRAPCSHADL-E--LHY-------- M_mulatta_ENSMMUP00000021905 --------------------------------------DH--Q-AHCEFA-LMDCP-------QCQHPFQKFHINI----HILKDCPRRQVSCDNCAASMAFIKR-S--V-D-------- O_latipes_ENSORLP00000001290 --------------------------------------KH--L-AQCQFA-TVPCS-------QCQQPVRKSYLEE----HATVECPRRPMSCPDCVAVFVYEER-E--MHE-------- C_elegans_Y110A7A.2 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP003004-PA --------------------------------------TH--L-RQCPFA-MS---------------------------RQSQPCPFARVKCKFVAPDEAAMS-----AHI-------- 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0111838 YCEAKCGQRILRGRMTLHKSKDCAKRLRRCAHCQREFSADTLPLHAAQCPRAPLACPQ--RCDA--GPIPRG-------ELEAHLRDECQSLA--------VSCSFKEAGCRFK---GPR A_aegypti_AAEL006649-PA YCESKCGTRVVRGRMSIHRAKDCAKRLRRCPHCSREFSADTLSAHGATCPRSPVPCPQ--RCDA--GPFARA-------DLEGHLRDECKALS--------VPCTFKEAGCRFK---GPR A_gambiae_AGAP010017-PA YCESKCGTRVLRGRMSIHRAKDCAKRLRRCPHCGREFCADTLAAHGATCPRSPIPCPQ--RCDA--GPFARA-------DLDAHLRDECKALT--------VPCTFKEAGCRFK---GPR X_tropicalis_ENSXETP00000056667 YCENKCGARMMRRVLSQHSLVECPKRTQPCPYCNKEFVFDTIQSHQYQCPRYPTPCPN--QCGI--ASIARE-------DLSNHLKDSCSSAL--------VLCPFKDSGCKHR---GPK M_musculus_ENSMUSP00000017530 YCENKCGARMMRRLLAQHATSECPKRTQPCAYCTKEFVYDTIQSHQYQCPRLPVPCPN--QCGV--GTVARE-------DLPTHLKDSCSTAF--------VLCPFKESGCKHR---CPK R_norvegicus_ENSRNOP00000018468 YCENKCGARMMRRLLAQHATSECPKRTQPCAYCTKEFVYDTIQSHQYQCPRLPVPCPN--QCGV--GTVARE-------DLPTHLKDSCSTAF--------VLCPFKESGCKHR---CPK P_troglodytes_ENSPTRP00000015252 YCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPN--QCGV--GTVARE-------DLPGHLKDSCNTAL--------VLCPFKDSGCKHR---CPK P_pygmaeus_ENSPPYP00000009119 YCENKCGARMMRRLLAQHATSECPKRTQPCTYCSKEFVFDTIQSHQYQCPRLPVACPN--QCGV--GTVARE-------DLPGHLKDSCNTAL--------VLCPFKDSGCKHR---CPK H_sapiens_ENSP00000262395 YCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPN--QCGV--GTVARE-------DLPGHLKDSCNTAL--------VLCPFKDSGCKHR---CPK T_rubripes_ENSTRUP00000012878 YCENKCGARMMRRLLSQHGMAECPKRTQPCKYCSKEFVFDTIQNHQYHCPRFPVQCPN--QCGT--PNIARE-------DLANHVKDNCGSAL--------VLCPFKDAGCKHR---CPK B_taurus_ENSBTAP00000050075 YCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVPCPN--QCGV--GTVARE-------DLPGHLKDSCSTAL--------VLCPFKDSGCKHR---CPK B_taurus_ENSBTAP00000016271 YCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVPCPN--QCGV--GTVARE-------DLPGHLKDSCSTAL--------VLCPFKDSGCKHR---CPK E_caballus_ENSECAP00000009502 YCENKCGARMMRRLLAQHATSECPKRTQPCTYCAKEFVFDTIQSHQYQCPRLPVPCPN--QCGV--GTVARE-------DLPGHLKDSCSTAL--------VLCPFKDSGCKHR---CPK M_mulatta_ENSMMUP00000028200 YCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVPCPN--QCGV--GTVARE-------DLPGHLKDSCSTAL--------VLCPFKDSGCKHR---CPK G_aculeatus_ENSGACP00000014759 YCENKCGARMMRRLLSQHGLAECPKRTQPCKYCGKEFVFDTIQNHQYHCPRFPVQCPN--QCGT--PNIARE-------DLANHVKDNCGSAL--------VLCPFKDAGCKHR---CPK O_latipes_ENSORLP00000005579 YCENKCGARMMRRLLSQHGMAECPKRTQPCKYCGKEFVFDTIQNHQFHCPRFPVQCPN--QCGT--PNIARE-------DLANHVKDNCGSAL--------VLCPFKDAGCKHR---CPK M_domestica_ENSMODP00000024090 YCENKCGARMMRRLLGQHMMAECPKRTQPCAYCTKEFVYDTIQNHQHQCPRYPIPCPN--QCGM--GSIPRE-------DLNSHLKENCSTVP--------VLCPFKDAGCKHR---CPK D_rerio_ENSDARP00000013849 YCENKCGARMMRRLLSQHTMTECPKRTQPCKYCGKEFVYDTIQNHQYHCPRFPVQCPN--QCGT--PNIARE-------DLANHVKESCGSAL--------VLCPFKEAGCKHR---CPK D_rerio_ENSDARP00000056877 YCENKCGARMVRRLLAQHSVSECLKRKLPCRYCKKEFLYDTIQNHQQQCPRFPMQCPN--RCGT--PGITRD-------TLMAHVKEGCSTAM--------VLCPFKEAGCKHR---SPK O_cuniculus_ENSOCUP00000000748 YCENKCGSRMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVPCPN--QCGV--GTVARE-------DLPGHLKDSCSTAL--------VLCPFKDSGCKHR---CPK T_nigroviridis_ENSTNIP00000019321 YCENKCGARMMRRLLSQHGMAECPKRTQPCKYCGKEFVFDTIQNHQYHCPRFPVQCPN--QCGT--PNIARE-------DLANHVKDNCGSAL--------VLCPFKDAGCKHR---CPK G_gorilla_ENSGGOP00000016344 YCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPN--QCGV--GTVARE-------DLPGHLKDSCNTAL--------VLCPFKDSGCKHR---CPK C_intestinalis_ENSCINP00000008928 HCENKCGAKMLRKYLSRHVTGDCPKRPTKCTHCSKDFNIDILQTHHGTCPRYPIGCPN--RCDV--LKIPRE-------ELEIHLKEHCKSAL--------TACPFKEAGCKHK---CPR C_familiaris_ENSCAFP00000027741 YCENKCGARMMRRLLAQHAASECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVPCPN--QCGV--GTVARE-------DLPGHLKESCSTAL--------VLCPFKDSGCNTG---CPA O_anatinus_ENSOANP00000019424 ----------------------------PCPYCTKEFVFDTIQNHQYQCPRFPLPCPN--QCGT--GAVARE-------DLPGHLKENCNTAP--------VLCPFKDAGCKHR---CPK C_intestinalis_ENSCINP00000003738 ----------------------------------------------KSCIRFPVTCPK--KCGT--KEIPRE-------ELNAHLELDCQLAD--------KVCPYETVGCTFT---CSR M_mulatta_ENSMMUP00000022296 -------------------------------------------------------CPNGLYCSV--GTVAQE-------DLP-HLKDSCSTAL--------VLCSFKDSSCKHR---CPK T_nigroviridis_ENSTNIP00000005138 ---------------------------------------------ETVCPAFPVSCPN--HCSF--SSLPRS-------ELSNHQH-ECPKAQ--------VSCQFHGYGCTFK---GLN T_rubripes_ENSTRUP00000013348 ---------------------------------------------ETVCPAFPVSCPN--HCSL--SSLPRS-------ELSSHQH-ECPKAQ--------VSCPFHGYGCTFK---GLN G_aculeatus_ENSGACP00000005703 ---------------------------------------------ETVCPAFPVSCPN--HCSV--SSLPRS-------ELSSHQN-DCPKAQ--------VCCQFQRYGCTFQ---GLN B_taurus_ENSBTAP00000017918 ---------------------------------------------DTECPCVAVSCPH--KCSV--QTLLRS-------ELSAHLS-ECVNAP--------STCSFKRYGCVFQ---GTN R_norvegicus_ENSRNOP00000010906 ---------------------------------------------DTDCPCVVVSCPH--KCSV--QTLLRS-------ELSAHLS-ECVNAP--------STCSFKRYGCVFQ---GTN C_familiaris_ENSCAFP00000026713 ---------------------------------------------DTECPCVVVSCPH--KCSV--QTLLRS-------ELSAHLS-ECVNAP--------STCSFKRYGCVFQ---GTN X_tropicalis_ENSXETP00000027864 ---------------------------------------------DVDCPSVVISCPH--MCSV--KSLLRS-------ELNAHLL-ECVNAP--------STCSFKRYGCTFK---GTN D_rerio_ENSDARP00000038596 ---------------------------------------------ETVCPAFPVACPN--HCSF--SSILRS-------ELSSHQH-DCPKAQ--------VTCSFIRYGCSYK---GLN E_caballus_ENSECAP00000011833 ---------------------------------------------DTECPCVVVSCPH--KCSV--QTLLRS-------ELSAHLS-ECVNAP--------STCSFKRYGCIFQ---GTN M_domestica_ENSMODP00000016701 ---------------------------------------------DTECPCVVVSCPH--KCSV--QTLLRS-------ELNAHLS-ECINAP--------STCSFKRYGCTFQ---GTN M_musculus_ENSMUSP00000021706 ---------------------------------------------DTDCPCVVVSCPH--KCSV--QTLLRS-------ELSAHLS-ECVNAP--------STCSFKRYGCVFQ---GTN O_anatinus_ENSOANP00000023053 ---------------------------------------------DTECPCVVVSCPH--KCSV--QTLLRS-------ELNAHLS-ECINAP--------STCSFKRYGCTFQ---GTN T_guttata_ENSTGUP00000013203 ---------------------------------------------DTECPCVMVSCPH--KCSV--KTLMRS-------ELNAHLS-ECINAP--------STCSFKRYGCTFQ---GTN G_gallus_ENSGALP00000036699 ---------------------------------------------DTDCPCVMVSCPH--KCSV--KTLMRS-------ELNAHLS-ECINAP--------STCSFKRYGCTFQ---GTN A_carolinensis_ENSACAP00000000193 ---------------------------------------------DADCPCVMVTCPH--KCSV--SALLRK-------ELNAHLS-ECINAP--------STCSFKRYGCTFQ---GTN M_musculus_ENSMUSP00000082710 ---------------------------------------------ENSCPAYPVSCPN--RCV---QTIPRA-------RVNEHLT-VCPEAE--------QDCPFKHYGCTVK---GKR P_pygmaeus_ENSPPYP00000007003 ---------------------------------------------DTDCPCVVVSCPH--KCSV--QTLLRS-------ELSAHLS-ECVNAP--------STCSFKRYGCVFQ---GTN P_troglodytes_ENSPTRP00000011503 ---------------------------------------------DTDCPCVVVSCPH--KCSV--QTLLRS-------ELSAHLS-ECVNAP--------STCSFKRYGCVFQ---GTN H_sapiens_ENSP00000376500 ---------------------------------------------DTDCPCVVVSCPH--KCSV--QTLLRS-------ELSAHLS-ECVNAP--------STCSFKRYGCVFQ---GTN E_caballus_ENSECAP00000005414 ---------------------------------------------ENMCPEYPVSCPN--KCL---QIIPRT-------EVDEHLA-VCPEAE--------QDCPFKQYGCPVK---DKR P_troglodytes_ENSPTRP00000003288 ---------------------------------------------ENLCPEYPVFCPN--NCA---KIILKT-------EVDEHLA-VCPEAE--------QDCPFKHYGCAVT---DKR P_pygmaeus_ENSPPYP00000000253 ---------------------------------------------ENLCPEYPVFCPN--NCA---KIILKT-------EVDEHLA-VCPEAE--------QDCPFKHYGCAVT---DKR M_mulatta_ENSMMUP00000038268 ---------------------------------------------ENLCPEYPVFCPN--NCA---KIILKT-------EVDEHLA-VCPEAE--------QDCPFKHYGCAVT---DKR H_sapiens_ENSP00000336825 ---------------------------------------------ENLCPEYPVFCPN--NCA---KIILKT-------EVDEHLA-VCPEAE--------QDCPFKHYGCAVT---DKR T_guttata_ENSTGUP00000003276 ---------------------------------------------KNDCPDYPVPCLQ--NCS---QIILKK-------EIEKHHA-VCPEAE--------VDCPYKQYGCHVK---VKR B_taurus_ENSBTAP00000015940 ---------------------------------------------ENLCPDYPVSCPN--KCL---QTIPRT-------EVDEHLA-VCPEAE--------QDCAFKNYGCAVK---DKR D_rerio_ENSDARP00000014326 ---------------------------------------------KSSCPDVEVPCSN--NCT---QMIKRH-------QLQAHAD-ECLEVE--------TDCVYKNYGCTVR---DKR C_intestinalis_ENSCINP00000003143 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000016021 ---------------------------------------------ENDCPDYPMPCLQ--NCS---QIILKK-------EIEKHHT-VCPETE--------VDCPYKQYGCLIK---VKR A_carolinensis_ENSACAP00000016112 ---------------------------------------------RRDCPEYPLICPH--GCT---QTILMK-------EAEEHIL-VCPAVE--------IDCPYKQYGCPAK---IKR M_domestica_ENSMODP00000003305 ---------------------------------------------EQFCPNYPVSCPN--NCL---QIITRT-------KVNEHIS-VCPEVE--------QECAYKHYGCPVK---DKR C_intestinalis_ENSCINP00000001022 ---------------------------------------------SGENSSFASSQPE----SV--DQIPQN-----------HLN-ESPYVL--------NNEALSLESSLTT---GDL C_intestinalis_ENSCINP00000027890 ---------------------------------------------STENVS-PSLQRS----SV-----FNS-----------WTS-KSPIDF--------SISEPSFNFNGLS---HPE M_mulatta_ENSMMUP00000015419 ---------------------------------------------DTDCPCVVVSCPH--KCSV--QTLLRS-------ELSAHLS-ECVNAP--------STCSFKRYGCVFQ---GTN G_gallus_ENSGALP00000002401 -----------------------------------------------HCPRKPKVCRS---EPAVILMTGTF-------MLSDHLR-ASSVSM--------DGCRFSEVGCSFG---GSK O_anatinus_ENSOANP00000013484 ---------------------------------------------ENFCPDYPVSCPF--SCC---QIIPRT-------EVDEHIS-VCPEAE--------QDCPYKQYGCLIK---DKR O_cuniculus_ENSOCUP00000007884 ---------------------------------------------ENLCPEYPVSCPN--KCL---QIIPRT-------EVNRHLA-VCPEAE--------QDCPFKQYGCTVK---EKR G_gorilla_ENSGGOP00000004192 ---------------------------------------------DTDCPCVVVSCPH--KCSV--QTLLRS-------ELSAHLS-ECVNAP--------STCSFKRYGCVFQ---GTN C_familiaris_ENSCAFP00000017853 ---------------------------------------------ENLCPEYPVPCPN--KCS---QIIPRT-------EVDEHLT-VCPEAE--------QDCPFKHYGCTVK---DKR T_rubripes_ENSTRUP00000047803 ---------------------------------------------D-ICLKFPLPCKD---CGK--KKIPRE-------KFNEHIR-SCAKSK--------SACPFSEVGCKSV---VDN P_troglodytes_ENSPTRP00000036949 ---------------------------------------------E-VCPKFPLTCDG---CGK--KKIPRE-------KFQDHVK-TCGKCR--------VPCRFHAIGCLET---VEG P_pygmaeus_ENSPPYP00000022191 ---------------------------------------------E-VCPKFPLTCDG---CGK--KKIPRE-------KFQDHVK-TCGKCR--------VPCRFHAIGCLET---VEG T_nigroviridis_ENSTNIP00000011878 ---------------------------------------------E-ICSKFPLQCKD---CGK--KKIPRE-------KFNEHIK-SCAKSK--------SACPFSEVGCKSV---VEN T_nigroviridis_ENSTNIP00000016461 ---------------------------------------------E-ICPKYPMICEG---CAK--KKIPRE-------KYVDHIK-FCSKFR--------TPCRFHVVGCDMS---VEK D_rerio_ENSDARP00000069217 ---------------------------------------------E-ICQKFPMQCKD---CGK--KKIPRE-------KFQEHTK-SCAKSK--------SACQFREIGCRAV---VDN T_guttata_ENSTGUP00000006737 -----------------------------------------------RTFLSQIKA-----FQLVLIISSTF-------FFSSH-S-TSSSNK--------DGCCFSEVGCAFR---GSK O_cuniculus_ENSOCUP00000003184 ---------------------------------------------XXXXXXXXXXXXX--XXXX--XXXXXX-------XLSAHLS-ECVNAP--------STCSFKRYGCVFQ---GTN O_latipes_ENSORLP00000001368 ---------------------------------------------QSSCPKVKGGCPD--GCS---TLVPKN-------RLTEHGE-SCPEVH--------TDCSFKMFGCSVK---GKR H_sapiens_ENSP00000247668 ---------------------------------------------E-VCPKFPLTCDG---CGK--KKIPRE-------KFQDHVK-TCGKCR--------VPCRFHAIGCLET---VEG T_nigroviridis_ENSTNIP00000013509 ---------------------------------------------E-ICPKYPMMCEG---CSR--RKIPRE-------KYVDHIK-YCSKFK--------SPCRFHVVGCNIK---VEK M_musculus_ENSMUSP00000109872 ---------------------------------------------E-VCPKFPLTCDG---CGK--KKIPRE-------TFQDHVR-ACSKCR--------VLCRFHTVGCSEM---VET M_domestica_ENSMODP00000021625 ---------------------------------------------E-ICPKFPLTCEG---CGK--KKILRE-------KFQDHVK-ACGKCK--------GPCKFHVVGCTEM---VEN G_aculeatus_ENSGACP00000006974 ---------------------------------------------E-ICPKYPMICEG---CAK--KKIPRE-------KYVDHIK-FCSKCK--------APCRFHVVGCDASVMEVEN O_latipes_ENSORLP00000008989 ---------------------------------------------E-ICQKFPLQCKD---CGK--KKIPRE-------KFNDHAK-SCAKSK--------SACPFSEVGCKSV---VEN G_gallus_ENSGALP00000014649 ---------------------------------------------E-VCPKFPLTCDG---CGK--KKIPRE-------KFQDHVK-NCGKCK--------VPCRFKVVGCAEM---VEN O_latipes_ENSORLP00000020860 ---------------------------------------------E-ICPKYPMMCEG---CAK--KKIPRE-------KYVDHIK-FCSKFK--------APCRFHVVGCDTS---VEK E_caballus_ENSECAP00000011150 ---------------------------------------------D-VCPKFPLTCDG---CGK--KKISRE-------KFQDHVR-TCGKCR--------VPCRFHAVGCPEM---VES T_rubripes_ENSTRUP00000011363 ---------------------------------------------E-ICPKYPMICEG---CSK--KKIPRE-------KYVDHIK-YCSKFK--------SPCRFHVVGCNTS---VEK B_taurus_ENSBTAP00000013869 ---------------------------------------------Q-ICPKFPLTCDG---CGK--KKIARE-------KFQDHVR-ACGRCR--------VPCRFHAVGCPEM---VES M_mulatta_ENSMMUP00000015132 ---------------------------------------------E-VCPKFPLTCDG---CGK--KKIPRE-------KFQDHVK-TCGKCR--------IPCRFHAIGCLET---VEG O_anatinus_ENSOANP00000001757 -------------------------------------------------------------------------------QFNSPGS-TASRIQ--------DGCPFSVIGCSFM--HGSR X_tropicalis_ENSXETP00000008559 ---------------------------------------------E-ICPKFPMTCEG---CGR--KKIPRE-------KFPDHVK-ICGRCK--------VPCRYAAVGCTEM---VEN C_familiaris_ENSCAFP00000028895 ---------------------------------------------E-VCPKFPLTCDG---CGK--KKISRE-------KFQDHVR-ACGKCR--------VPCRFHVVGCPEM---VES O_latipes_ENSORLP00000003220 ---------------------------------------------E-ICPKYPMICEG---CAK--KKIPRE-------KYVDHIK-FCSKFR--------TPCRFHVVGCDMS---VEK D_rerio_ENSDARP00000043465 ---------------------------------------------E-ICPKYPMICEG---CAK--KKIPRE-------KYVDHIK-LCTKFR--------TPCRFHVVGCDMT---VEK G_aculeatus_ENSGACP00000022084 ---------------------------------------------E-ICLKFPLQCKD---CGK--KKIPRE-------KFNDHSK-SCAKSK--------SSCPFNDVGCKYM---MEN T_rubripes_ENSTRUP00000015632 ---------------------------------------------E-ICPKYPMICEG---CAK--KKIPRE-------KYVDHIK-FCSKFR--------TPCRFHVVGCDMS---VEK C_elegans_F45G2.6 ----------------------------------------------KTCPQVIISCPF--QCGL--TDRPRL-------EIEAHCP-SCPNVD--------NVCPFVPYGCTFA---GGK D_rerio_ENSDARP00000091948 -----------------------------------------------LLKKEKHVCPS---SGDKKTAKTDK-------KQKNNQP-ANSKKK--------EPCIFSDVGCPFK---GNP A_carolinensis_ENSACAP00000005007 ----------------------------------------------GVCLLANVCCEY---CN---TVLIRE-------QLPNHYDNDCPTAP--------VPCTYSDFGCPEK---MQR E_caballus_ENSECAP00000009372 ---------------------------------------------------------------------------------------AVAEAG--------VGCPFAGVGCSFK---GSP G_aculeatus_ENSGACP00000020860 ---------------------------------------------E-ICPKYPMICEG---CAK--KKIPRE-------KYVDHIK-FCSKFR--------TPCRFHVVGCDMS---VEK D_rerio_ENSDARP00000036715 ----------------------------------------------QFCPFANTVCEY---CE---MELIRD-------QLALHCDTDCLKAP--------VACTFSTFGCREK---MTR T_guttata_ENSTGUP00000002510 ---------------------------------------------E-ETPHCECSWRN---CEGIWKKHPGA-------AFRDHVK-TCGRSK--------VPCRFEAVGCAEV---VEN M_domestica_ENSMODP00000024498 -------------------------------------------------------------------------------------L-VPAEDQ--------DRCPFADIGCSFK---GGQ T_guttata_ENSTGUP00000010462 ----------------------------------------------QTCPLANIYCEY---CN---TVLIRE-------QMPNHYDNDCPTAP--------VPCFYSAFGCPEK---MQR O_anatinus_ENSOANP00000018657 ----------------------------------------------QNCPLASVFCEY---CS---TVLIRE-------QMPTHYDMDCPTAP--------IPCTFSSFGCREK---MQR X_tropicalis_ENSXETP00000031605 ---------------------------------------------GLYCQLYPVPCPN--ACP---VTCPRA-------ELDKHLC-ECPEAE--------LQCTFSNYGCNVM---VKR H_sapiens_ENSP00000316840 ----------------------------------------------QNCPLANVICEY---CN---TILIRE-------QMPNHYDLDCPTAP--------IPCTFSTFGCHEK---MQR P_pygmaeus_ENSPPYP00000003845 ----------------------------------------------QNCPLANVICEY---CN---TILIRE-------QMPNHYDLDCPTAP--------IPCTFSTFGCHEK---MQR P_troglodytes_ENSPTRP00000006096 ----------------------------------------------QNCPLANVICEY---CN---TILIRE-------QMPNHYDLDCPTAP--------IPCTFSTFGCHEK---MQR T_nigroviridis_ENSTNIP00000012472 ----------------------------------------------QQCPFASVMCPH---CD---MDLTRD-------QMESHCDTDCPKAP--------IACNFSLFGCKER---MQR M_mulatta_ENSMMUP00000021907 ----------------------------------------------QNCPLANVICEY---CN---TILIRE-------QMPNHYDLDCPTAP--------IPCTFSTFGCHEK---MQR B_taurus_ENSBTAP00000021630 ----------------------------------------------QNCPLANVICEY---CN---TMLIRE-------QMPNHYDLDCPTAP--------VPCTFSAFGCHEK---MQR C_familiaris_ENSCAFP00000010159 ----------------------------------------------QNCPLANVICEY---CN---TMLIRE-------QMPNHYDLDCPTAP--------IPCTFSTFGCHVK---MQR M_domestica_ENSMODP00000024756 ----------------------------------------------QNCPLATVFCEY---CS---TMLIRE-------QMPNHYDIDCPVAP--------IPCTFSTFGCREK---MPR R_norvegicus_ENSRNOP00000006148 ----------------------------------------------QSCPLANIICEY---CG---TILIRE-------QMPNHYDLDCPTAP--------VPCTFSVFGCHEK---MQR G_aculeatus_ENSGACP00000022648 ----------------------------------------------QRCPFAIVKCLF---CD---LELIRD-------QIESHCDTDCPKAP--------IACNFSAFGCKES---MQR T_rubripes_ENSTRUP00000041697 ----------------------------------------------QQCPFASVMCPY---CD---MDLVRD-------QMESHCDTDCPIAP--------IACTFSLFGCKER---MQR M_musculus_ENSMUSP00000004949 ----------------------------------------------QSCPLANIICEY---CG---TILIRE-------QMPNHYDLDCPTAP--------IPCTFSVFGCHEK---MQR G_gallus_ENSGALP00000012873 ----------------------------------------------QTCPLANVFCEY---CN---TMLIRQ-------QMPNHYDNDCPTAP--------VPCFYSAFGCPEK---MQR A_carolinensis_ENSACAP00000006987 ---------------------------------------------E-VCPKFPLTCEG---CGK--RKIPRE-------KFPEHVK-SCSKCK--------APCRFQPIGCNVV---VSP X_tropicalis_ENSXETP00000016445 ----------------------------------------------QTCPLAYVTCEY---CQ---TNLIRE-------QMPAHYSMDCTMAP--------IPCMYYEFGCTEK---MQR E_caballus_ENSECAP00000018618 ----------------------------------------------QNCPLANVICEY---CN---TMLIRE-------QMPNHYDLDCPTAP--------IPCTFNTFGCHEK---MQR O_cuniculus_ENSOCUP00000010330 ----------------------------------------------QNCPLANVICEY---CN---TMLIRE-------QMPNHYDLDCPTAP--------IPCTFSTFGCHEK---MQR R_norvegicus_ENSRNOP00000058607 ---------------------------------------------E-VCPKFPLTCDG---CG---KKISQE-------KLQDHVR-TCSKCR--------VLCRFHAIGCSEL---VET M_mulatta_ENSMMUP00000021905 ----------------------------------------------QNCPLANVICEY---CN---TILIRE-------Q-ASYYDVDCPTAP--------IPCTFRTFDCHEK---MQR O_latipes_ENSORLP00000001290 ----------------------------------------------QQCPFASVMCQY---CE---MDLIRD-------QMESHCDTDCPKAP--------IACTFSIFGCKER---MQR C_elegans_Y110A7A.2 ---------------------------------------------SASNPPTPLDSPF--MAGA--INRPRTSTRSVGVSIPIHVEGEEPTAPKSIVPDNWIDCPFKEHGCHKK---GEN A_gambiae_AGAP003004-PA ---------------------------------------------ASDCQQHLQVARS--PCVSA-LTVTKF-------EFSPFTI-----------------CSY----CSRR---GSN 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0111838 QMLEAHLESNA---AAHLSLMV-------------------------------------------------------------------------------------------------- A_aegypti_AAEL006649-PA HLLEAHLESNT---SSHLSLMV-------------------------------------------------------------------------------------------------- A_gambiae_AGAP010017-PA HLLEAHLEANT---SAHLSLMV-------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000056667 ITISRHLEENM---RAHLSMMS-------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000017530 LAMGRHVEESV---KPHLAMMC-------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000018468 LAMGRHVEESV---KPHLAMMC-------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000015252 LAMARHVEESV---KPHLAMMC-------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000009119 LAMARHVEESV---KPHLAMMC-------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000262395 LAMARHVEESV---KPHLAMMC-------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000012878 LAIGRHLEDTT---KSHLTMMC-------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000050075 LAMARHVEESV---KPHLAMMC-------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000016271 LAMARHVEESV---KPHLAMMC-------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000009502 LAMARHVEESV---KPHLAMMC-------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000028200 LAMARHVEESV---KPHLAMMC-------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000014759 LAIGRHLEDTT---KSHLTMMC-------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000005579 LAIGRHLEDTT---KSHLTMMC-------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000024090 LAMGRHMEESV---KPHLAMMC-------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000013849 MAIGRHLEEST---KSHLTMMC-------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000056877 TGVARHLEEAA---PTHLSLLC-------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000000748 LAMARHVEESV---KPHLAMMC-------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000019321 LAIGRHLEDTT---KSHLTMMC-------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000016344 LAMARHVEESV---KPHLAMMC-------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000008928 YHLERHLTEAN---ASHIRAMF-------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000027741 FPLAPLVPEASYADQAHGGSCC-------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000019424 LAMSRHLEDSV---KLHLGLTW-------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000003738 EKMATHVDECF---RKHVSLLC--DGFRKQ------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000022296 WAMAWHVEESV---KPHLVMMC-------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000005138 QLMRQHESTSA---AEHLRMMA--KRNSMLEGKLDDVKGEL-LERLKHLPVVSSRVSE-----------------------------LENA---SDELR-------EKNRQMEQKLATMQ T_rubripes_ENSTRUP00000013348 QVMRQHESSSA---AEHLRMMA--KRNSALESKLDDVKGEL-LERFKVLPVLSSRVAE-----------------------------LESS---NDELR-------EKNRQTEQKLGTMQ G_aculeatus_ENSGACP00000005703 QDMRQHESTSA---GEHLRMIA--NKNSVLENKVEDIKGEL-LERYKVLPALSSRLSE-----------------------------LENQ---SDELR-------EKNRQVEQKLATMQ B_taurus_ENSBTAP00000017918 QQIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQICS-----------------------------FEIE---IERQK-------EMLRNNESKILHLQ R_norvegicus_ENSRNOP00000010906 QQIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQICS-----------------------------FEIE---IERQK-------EMLRNNESKILHLQ C_familiaris_ENSCAFP00000026713 QQIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQICS-----------------------------FEIE---IERQK-------EMLRNNESKILHLQ X_tropicalis_ENSXETP00000027864 QQIKAHEASSA---VQHVNLMK--EWSNYLEAKVSMLQNES-SEKNKSIQILHNQMCS-----------------------------FEIE---IERHK-------EQLRNNEARIIQLQ D_rerio_ENSDARP00000038596 QEMREHESSFA---SEHLRMMA--VRNTTLEAKVEDVKSEL-MERYKVLPSLSSRLAE-----------------------------VERQ---YEEMR-------EKNRQLEQKLVSMQ E_caballus_ENSECAP00000011833 QQIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQICS-----------------------------FEIE---IERQK-------EMLRNNESKILHLQ M_domestica_ENSMODP00000016701 QQIKTHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQICS-----------------------------FEIE---IERQK-------EMLRNNESKILHLQ M_musculus_ENSMUSP00000021706 QQIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQICS-----------------------------FEIE---IERQK-------EMLRNNESKILHLQ O_anatinus_ENSOANP00000023053 QQIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQICS-----------------------------FEIE---IERQK-------EMLRNNESKILHLQ T_guttata_ENSTGUP00000013203 QQIKAHEASSA---VQHVNLLK--EWSNALENKVALLQNES-LEKNKSIQTLHNQICS-----------------------------FEIE---IERQK-------EMLRNNESKILHLQ G_gallus_ENSGALP00000036699 QQIKAHEASSA---VQHVNLLK--EWSNALENKVALLQNES-LEKNKSIQTLHNQICS-----------------------------FEIE---IERQK-------EMLRNNESKILHLQ A_carolinensis_ENSACAP00000000193 QQVKAHETSSA---VQHVDLLK--EWSNCLENKVAMLQNES-LEKNKSIQTLHNQICS-----------------------------FEIE---IERQK-------EMLRSNESKIHHLQ M_musculus_ENSMUSP00000082710 GNLLEHERAAL---QDHMLLVL--EKNYQLEQRVSRIIEAL-SRKQTHSQRLPLTAPK-----------------------------KKKE---HPALR-------PICSVSGTLVSSGK P_pygmaeus_ENSPPYP00000007003 QQIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQICS-----------------------------FEIE---IERQK-------EMLRNNESKILHLQ P_troglodytes_ENSPTRP00000011503 QQIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQICS-----------------------------FEIE---IERQK-------EMLRNNESKILHLQ H_sapiens_ENSP00000376500 QQIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQICS-----------------------------FEIE---IERQK-------EMLRNNESKILHLQ E_caballus_ENSECAP00000005414 GNLQEHEHSAL---RDHMLLVL--EKNLQLEKQISDLHRSL-ERKESKIQQLTETVNK-----------------------------FEKE---FKQFA-------QLFGKNGSFLSNIQ P_troglodytes_ENSPTRP00000003288 RNLQEHEHSAL---REHMRLVL--EKNVQLEEQISDLHKSL-EQKESKIQQLAETIKK-----------------------------LEKE---FKQFA-------QLFGKNGSFLPNIQ P_pygmaeus_ENSPPYP00000000253 RNLQEHERSAL---REHMRLVL--EKNVQLEEQISDLHKSL-EQKESKIQQLAETIKK-----------------------------LEKE---FKQFA-------QLFGKNGSFLPNIQ M_mulatta_ENSMMUP00000038268 RNLQEHEHSAL---REHMRLVL--EKNVQLEEQISDLHKSL-EQKESKIQQLAETIKK-----------------------------LEKE---FKQFA-------QLFGKNGSFLPNIQ H_sapiens_ENSP00000336825 RNLQQHEHSAL---REHMRLVL--EKNVQLEEQISDLHKSL-EQKESKIQQLAETIKK-----------------------------LEKE---FKQFA-------QLFGKNGSFLPNIQ T_guttata_ENSTGUP00000003276 GKLAEHENSAL---REHMLQIL--DKNSRLEEQISDLYKNL-EYKEIKIQQLADAIKK-----------------------------CEKE---FRQYT-------QLFGNNSNLMVSTQ B_taurus_ENSBTAP00000015940 GNLQEHERSAL---RDHMLLVL--EKNFQLEEQISDLYKSL-EQKESKIQQLAEMVKK-----------------------------FEKE---FKQFA-------QLFGKNGSFLSNMQ D_rerio_ENSDARP00000014326 GKVQVHENTEF---SAHVRLVL--EKLCEQTLCSLTMQSRV------------------------------------------------------------------------STFSCDR C_intestinalis_ENSCINP00000003143 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000016021 GKLAEHENGAL---REHMLQIL--DKNSRLEEQISDLYKSL-ECKEIKIQQLAEAVKK-----------------------------CEKE---FRQFT-------QLFGKNSNLMVSTQ A_carolinensis_ENSACAP00000016112 GKVLEHENIYL---REHMLQIL--DRNSKLEDQISELYKNL-EHKEIKIQHLADMVKK-----------------------------CEKE---FRQFT-------QLYSKNNNLLASTQ M_domestica_ENSMODP00000003305 SNLKKHENSAL---REHMLLVL--ERNSRLEEQIFDLHKNL-ELKESKIQQLSETVKK-----------------------------FEKE---FRQFV-------QLFGKNGNLLASTQ C_intestinalis_ENSCINP00000001022 NSVKAQCEYSH---KILQRQLQ--EMKNAVE-----LEMRK-RESDRDGNVLRANITK-----------------------------L------------------------EQRLTALQ C_intestinalis_ENSCINP00000027890 VGISDYCKSEH---DALRSHLA--EISQTL-------------NNLKNSNDVSPEIRK-----------------------------L------------------------EVRLKAIQ M_mulatta_ENSMMUP00000015419 QQIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQICS-----------------------------FEIE---IERQK-------EMLRNNESKILHLQ G_gallus_ENSGALP00000002401 EKIKEHEKAAV---GTHMLLLL--QYIKQLKANLCTVSK-------------------------------------------------------AANGFISQTEL-----NLENKLHVFE O_anatinus_ENSOANP00000013484 RNLREHENAAL---REHMLLVL--DKNSRLEEKISDLHRSL-EVKELKIQQLAEMVKK-----------------------------FEKE---FRQVM-------QLFSKNGNLLANTQ O_cuniculus_ENSOCUP00000007884 GSLQEHEHSAL---REHMLLVL--EKNFRLEEQISDLCKSL-EQKESKIQQLAETVKK-----------------------------FEKE---FKQFA-------QLFGKNGSFLSNIQ G_gorilla_ENSGGOP00000004192 QQIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQICS-----------------------------FEIE---IERQK-------EMLRNNESKILHLQ C_familiaris_ENSCAFP00000017853 GSLQEHEHSAL---RDHMLLVL--EKNLQLEEQISDLYKSL-EQKESKIQQLAETVKK-----------------------------FEKE---FKQFA-------QLFGKNGSFLSNIQ T_rubripes_ENSTRUP00000047803 GKLREHEHSST---VEHLHLLL--PMVLSLTRTRAEVSESG-EWQEDSGLGLYRAPEEGV---------------------------NVGA---GAAAS-------VHAVDLEKKVTALE P_troglodytes_ENSPTRP00000036949 EKQQEHEAQWL---REHLAMLL--SSVLEAKPLSGDQ---------------------------------------------------SHA---GSELL-------QRCESLEKKTATFE P_pygmaeus_ENSPPYP00000022191 EKQQEHEAQWL---REHLAMLL--SSVLEAKPLSGDQ---------------------------------------------------SHA---GSELL-------QRCESLENKTATFE T_nigroviridis_ENSTNIP00000011878 GKLSEHENSST---MEHMRLLL--PIVLSLTQARAEVSDSG-EWQEDSVLGLYRAPEEGV---------------------------HVGA---GAAAS-------VH-VNLEKKVTALE T_nigroviridis_ENSTNIP00000016461 EKIHDHERAFA---YEHLNLLL--HYIMGMKASRAG---------------------------------------------------EKTK---VAELG-------RRCTELEVKANTFE D_rerio_ENSDARP00000069217 CKQQEHEQTSI---MEHLRLML--ALLSSMRLR---AEGAG-EWQEDVGLGLYRGPEDAP---------------------------PAGA---HNVGR-------GGGPGVQKKVTTLE T_guttata_ENSTGUP00000006737 EKIQEHQNSAV---GAHMLLLL--QHMRQLQGTLC------------------------------------------------------------SKGFSPRPELNKVISELENKLHVFE O_cuniculus_ENSOCUP00000003184 QQIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQICS-----------------------------FEIE---IERQK-------EMLRNNESKILHLQ O_latipes_ENSORLP00000001368 RKVKLHEEAAV---CHHVLLVL--KSSAHLEQQVVFVQKEA-LLRQQEVQTDTLLLSD-----------------------------LQEQ---LGSVL-------QQSRSQEHIVATAQ H_sapiens_ENSP00000247668 EKQQEHEVQWL---REHLAMLL--SSVLEAKPLLGDQ---------------------------------------------------SHA---GSELL-------QRCESLEKKTATFE T_nigroviridis_ENSTNIP00000013509 EKIHEHERQCS---YEHLNLLL--HFIMGIKSS-------------------------------RA---------------------KKTK---VAELS-------RRCQELEVKVSTLE M_musculus_ENSMUSP00000109872 ENLQDHELQRL---REHLALLL--SSFLEAQASPGTL---------------------------------------------------NQV---GPELL-------QRCQILEQKIATFE M_domestica_ENSMODP00000021625 EKQQDHENQKV---AEHLCMLL--NFVLEARHFHGDI--------------------------------------------------EMSK---STELL-------ERCETLERKTVTFE G_aculeatus_ENSGACP00000006974 EKLHDHERQCS---YEHLNLLL--HFIMGIK------------------------------LQLQS---------------------EKAK---VAELS-------RRCQELELKVGTFE O_latipes_ENSORLP00000008989 GKISEHEHSST---MEHLRLLL--PMVLSMTRTRLDTSPSG-EWQEDSGLGLYRAPDD-------------------------------GC---GAAAS-------VPSVDLDKKVSALE G_gallus_ENSGALP00000014649 EKLPEHESKCL---AEHLYMLL--SFVLSLKSGSGDLKHLPAIPSSQSSSPLLAANSLCPE-------------------------SELFK---SLELL-------GRCDALEKKTVTFE O_latipes_ENSORLP00000020860 EKIHDHERQCS---YEHLNLLL--HFIMGIKGVCAATLATS-------FTPLHSAMGAALELQLQS---------------------EKTK---VAELS-------RRCQELELKVSTFE E_caballus_ENSECAP00000011150 EKQQEHEAKWL---QEHLAMLLDSSSFLGQSQVGNPG-------------------------------------------------AEVSK---AAELL-------QRCEALERKTATFE T_rubripes_ENSTRUP00000011363 EKIHDHERQCS---YEHLNLLL--HFIMGIKISLESLPPQSLDVASHKLLELHQSL-RDLELKLQS---------------------EKTK---VAELS-------RRCQDLELKVRTFE B_taurus_ENSBTAP00000013869 EQQPEHEAQRL---QEHLALLL--GVLLEAGRPPGDS-------------------------------------------------RLLLR---VAELL-------QRCEALERKTATFE M_mulatta_ENSMMUP00000015132 EKQQEHEAQWL---REHLAMLL--SSVLEAKPLLGDQ---------------------------------------------------SHA---GSELL-------QRCENLEKKTATFE O_anatinus_ENSOANP00000001757 EKVKEHETSSM---DMHLGLLL--QAVSQTKANQGDCEEEL-----------------------------------------------------ALQRFMRE----KLISDLEEKLHVFE X_tropicalis_ENSXETP00000008559 DKCLEHENKSL---AEHLAKGS--PAPPANAPPNNSAK--------------------------------------------------------VAEML-------LKFDTLDKKNTTFE C_familiaris_ENSCAFP00000028895 EKQQQHEAHWL---REHLAMLL--GSLLEAKHLSGAG--------------------------------------------------GPFL---GLKLQ-------QRCEALERKTATFE O_latipes_ENSORLP00000003220 EKIHDHERAFA---YEHLNLLL--HYIMGMKVSMEGLQPQGLETAGHKLVELQKSL-RDLEARVSQLSTTSSG--------------PPVQ---GAAAS-------SSSSRLEVKSGTFE D_rerio_ENSDARP00000043465 EKIHDHEQACS---YEHLNLLL--HFIMGIKVNLESLQPQSLELASHKIHELHQSL-RELEL--------------------------------------------KMGQELELKVNTFE G_aculeatus_ENSGACP00000022084 GKLGDHEHSSA---VEHLRLLL--PLVLS-SVSLAGGDAAG-ELQEDSGLGLYRAPEEGV---------------------------ATGA---GAAAS-------ALSLDMEKKVNALE T_rubripes_ENSTRUP00000015632 EKIHDHERAYA---YEHLNLLL--HYIMGMKVSMEGLQPQGLEVAGQKLVELQQSL-RELELSVSTSFTPLPSSVGAALELQLHS--EKTK---VAELG-------RRCTELEVKANTFE C_elegans_F45G2.6 ESIQQHLSDEP---VRHLMYLC--DEITDLKGTYELMERD-------------------------------------------------------------------------------- D_rerio_ENSDARP00000091948 DKVKEHESCSH---AGHLQLLL--DVTRALQRTL-----NSATERVYQDSPVFLEPGPNGSSL----APQADGDIETD-----GGDPGVEL---A-----AG----QQLDALQQKVQVIE A_carolinensis_ENSACAP00000005007 NELARHWQEFT---QVHMRMMA--QTLRNVHVTNPAS---GN---F-------------------------HAMPPS------CE------------CS-------PEVRNFKETIQQLE E_caballus_ENSECAP00000009372 KFMQEHEVASQ---ATHLNLVL--GFMKQWKAQLGSGLGSG-----------PMALEQNLSDLQLQAAVEVAGDLEVDCYRAPCSESQEEL---ALQHFMKE----KLLAELEGKLRVFE G_aculeatus_ENSGACP00000020860 EKIHDHERAFA---YEHLNLLL--HYIMGMKVSMEGLQPQGLELAGHKLLELQQAL-RELEARVSQLSTTSSG--------------PPVQ-----------------CTELEVKAGTFE D_rerio_ENSDARP00000036715 NELAQHMQEFT---QMHMRYMA--EFLRSQTLNNCTMPSA------------AAHLS---------SDDRGASARSP------DSCQ----------CK-------QELLNLRETVLELE T_guttata_ENSTGUP00000002510 EKLPEHERKCL---AEHLYMLM--SSVLSLKTGAGDL-----------------------------------------------------K---PLPLL-------GRCEALERKTVTFE M_domestica_ENSMODP00000024498 ERVKEHEASSL---SDHLRRLL--ELVIRTKVQAGPSRGRGASGRRQAAEPEPKAPERNLSDLQLQGAVEVNGDLEADYFHAASSDSEEEL---ALQRFMKE----KLLSELEEKLRVFE T_guttata_ENSTGUP00000010462 NELARHMQEFT---QVHMRMMA--QSFQNISVTAANP---VP---FINGLPFEPALF---------S----HVSHAA------YN------------CN-------PEVENFKETIQQLE O_anatinus_ENSOANP00000018657 NQLARHLQDDT---QAHMRMMA--QALHSISITALTP---VP---QLDVLPFDPA----------------SLPRSS------SGYD----------CH-------PEVQNFQETIQQLE X_tropicalis_ENSXETP00000031605 GKVKEHEDTFL---RDHMLYVL--NRNMKLEEQVLGLQQNL-DLKEHQIQQLSDTVKW-----------------------------CEKE---CHQFG-------QFTGSNGNSLSSTK H_sapiens_ENSP00000316840 NHLARHLQENT---QSHMRMLA--QAVHSLSV--------IP----------------------------------D------SG------------YI-------SEVRNFQETIHQLE P_pygmaeus_ENSPPYP00000003845 NHLARHLQENT---QSHMRMLA--QAVHSLSL--------IP----------------------------------D------SG------------YI-------SEVRNFQETIHQLE P_troglodytes_ENSPTRP00000006096 NHLARHLQENT---QSHMRMLA--QAVHSLSL--------IP----------------------------------D------SG------------YI-------SEVRNFQETIHQLE T_nigroviridis_ENSTNIP00000012472 HDLARHMQDFT---QMHMHYMA--DFLRSLNLNGTIPKDQGA----------AASAS---------SCSKGALSSNC------TPCQ----------PT-------EEMQRLR----EMD M_mulatta_ENSMMUP00000021907 NHLARHLQENT---QSHMRMLA--QAVHSLSL--------IP----------------------------------D------SG------------YV-------SEVRNFQETIHQLE B_taurus_ENSBTAP00000021630 NHLARHLQENT---QSHMRMMA--QAVQTLSL-AVAP---VP---QCTMPLYDSV----------------PPTRPS------SG------------RH-------SEVHNFQETIQQLE C_familiaris_ENSCAFP00000010159 NHLARHLQENT---QSHMRMLG--QAVQSLSL-ALAP---VP---QRDVPPYDSS----------------SVSRVS------ST------------CH-------PEVQNFQETIQQLE M_domestica_ENSMODP00000024756 NHLARHLQEDT---LAHMRMMA--QAIENISIAAFNPK--LH---QREASSYDTS----------------PLPRTP---------------------Y-------PGPQNFQETIQQLE R_norvegicus_ENSRNOP00000006148 NHLARHLQENT---QLHMRLLA--QAVHNVNL-SLRP---CD------------------------------ASSPS------RG------------CR-------PEDPNYEETVKQLE G_aculeatus_ENSGACP00000022648 HNLAQHMQEFT---QMHMRYMA--EFLRGLSLNGTTPKSLWAPAPSAYPEDQGATAALAAVCSGPRGAPSSMSSNSC------APSQ----------PA-------EGMQRLR----EMD T_rubripes_ENSTRUP00000041697 HDLARHMQDFT---QMHMHYMA--DFLRGLNLNGTTPKPLGAIGHSISFEDHGASAS---------SCDKGVSSSNC------APCQ----------PN-------EETQRLR----EMD M_musculus_ENSMUSP00000004949 NHLARHLQENT---QLHMRLLA--QAVHNVNL-ALRP---CD------------------------------AASPS------RG------------CR-------PEDPNYEETIKQLE G_gallus_ENSGALP00000012873 NELARHMQEFT---QVHMRMMA--QSIQNISVTATNP---VP---FINGLPFEPALF---------S----HVSRAP------YN------------CN-------PEVENFKETIQQLE A_carolinensis_ENSACAP00000006987 SRWDE-AGPII---YKYC------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000016445 NDLARHLQEFT---QAHMRMMA--QTLRSFSS-SVTPTSHMPDISFCDPSQFEPAPP---------SVATVHSSHTP------SQND----------CT-------QETRNLRETIEQLE E_caballus_ENSECAP00000018618 NHLARHLQENT---QSHMRMLA--QAVQSLSL-ALAP---VP---QRDMLPYDSA----------------PLSRVS------SG------------CY-------PEVRNFQETIQQLE O_cuniculus_ENSOCUP00000010330 NHLARHLQEKT---QLHMRMLA--QAVHSLNL-ALTP---IP----------------------------------D------SG-------------Y-------PEGHNFQETIQQLE R_norvegicus_ENSRNOP00000058607 EDLQDHELQRL---REHLALLL--SSFLESQASQNQV---------------------------------------------------------GPELL-------QRCQILEQKIATFE M_mulatta_ENSMMUP00000021905 NHLSHHLQE-T---PCHTRMLT--QAVHSLSL--------IP----------------------------------D------SG------------YI-------SEARNFQETSHQLE O_latipes_ENSORLP00000001290 HNLAQHMQEFT---QMHMRYMD--IRMTTLTKKTKTTKNALIVIYFFFPKICVFLVQLQ-------HRLRGSSTRSAASQLILQSCEFTLYSHSKRLVK-------NCFYHLR-NVAKLK C_elegans_Y110A7A.2 SEVKRHVRDDR---NLHLVLLC--QSLNPIRTKINIQQ---------------------------------------------------------------------------------- A_gambiae_AGAP003004-PA DRYKFWDPPA----KNSVPEMS-----------------------------------------------------------------------------------------TNELVRSM- 610 620 630 640 650 660 670 680 690 700 710 720 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0111838 -----------------------------------------------------------------------------------------------------------------------A A_aegypti_AAEL006649-PA -----------------------------------------------------------------------------------------------------------------------A A_gambiae_AGAP010017-PA -----------------------------------------------------------------------------------------------------------------------A X_tropicalis_ENSXETP00000056667 -----------------------------------------------------------------------------------------------------------------------S M_musculus_ENSMUSP00000017530 -----------------------------------------------------------------------------------------------------------------------A R_norvegicus_ENSRNOP00000018468 -----------------------------------------------------------------------------------------------------------------------A P_troglodytes_ENSPTRP00000015252 -----------------------------------------------------------------------------------------------------------------------A P_pygmaeus_ENSPPYP00000009119 -----------------------------------------------------------------------------------------------------------------------A H_sapiens_ENSP00000262395 -----------------------------------------------------------------------------------------------------------------------A T_rubripes_ENSTRUP00000012878 -----------------------------------------------------------------------------------------------------------------------N B_taurus_ENSBTAP00000050075 -----------------------------------------------------------------------------------------------------------------------A B_taurus_ENSBTAP00000016271 -----------------------------------------------------------------------------------------------------------------------A E_caballus_ENSECAP00000009502 -----------------------------------------------------------------------------------------------------------------------A M_mulatta_ENSMMUP00000028200 -----------------------------------------------------------------------------------------------------------------------A G_aculeatus_ENSGACP00000014759 -----------------------------------------------------------------------------------------------------------------------N O_latipes_ENSORLP00000005579 -----------------------------------------------------------------------------------------------------------------------N M_domestica_ENSMODP00000024090 -----------------------------------------------------------------------------------------------------------------------A D_rerio_ENSDARP00000013849 -----------------------------------------------------------------------------------------------------------------------S D_rerio_ENSDARP00000056877 -----------------------------------------------------------------------------------------------------------------------G O_cuniculus_ENSOCUP00000000748 -----------------------------------------------------------------------------------------------------------------------A T_nigroviridis_ENSTNIP00000019321 -----------------------------------------------------------------------------------------------------------------------N G_gorilla_ENSGGOP00000016344 -----------------------------------------------------------------------------------------------------------------------A C_intestinalis_ENSCINP00000008928 -----------------------------------------------------------------------------------------------------------------------D C_familiaris_ENSCAFP00000027741 -----------------------------------------------------------------------------------------------------------------------E O_anatinus_ENSOANP00000019424 -----------------------------------------------------------------------------------------------------------------------A C_intestinalis_ENSCINP00000003738 ----------------------------------------------------------------------------------------------------------------------AE M_mulatta_ENSMMUP00000022296 -----------------------------------------------------------------------------------------------------------------------A T_nigroviridis_ENSTNIP00000005138 KLMSSHSEKLLEVELEL-----------RALRGL---RD---EVENLRGSLEGFRTRLS-ALEQGGRGGSGS-THTLASLEAQ--------------------------MNRH-----DD T_rubripes_ENSTRUP00000013348 KLMSSHSEKLLELELEL-----------RSLRGL---RD---EVENLRGTLESVRTRLN-ALEQGGRSGSGS-THTLASLEAQ--------------------------MNRH-----DD G_aculeatus_ENSGACP00000005703 KLMSSHSEKLLEVELEL-----------RSLRVL---RD---EVENLRGTLENVRTRLN-TLEQGGRSGTGSTTHTLATLENQ--------------------------LKRH-----DE B_taurus_ENSBTAP00000017918 RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT-ELESVDKSAGQA-ARNTGLLESQ--------------------------LSRH-----DQ R_norvegicus_ENSRNOP00000010906 RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT-ELESVDKSAGQA-ARNTGLLESQ--------------------------LSRH-----DQ C_familiaris_ENSCAFP00000026713 RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT-ELESVDKSAGQA-ARNTGLLESQ--------------------------LSRH-----DQ X_tropicalis_ENSXETP00000027864 RVIEGQADKLKDLDKEI-----------RNLRQT---GD---EADGMKSNYESLQNRLS-QLEVMAKNA--A-SWNPGVLETQ--------------------------INRH-----DQ D_rerio_ENSDARP00000038596 MLMSSHSEKLLEVEMEL-----------RELRPLRAMRE---EVETLRGSVESMRSMVS-SLDSSCVNSASG-SHTLASLEQQ--------------------------LTRH-----DD E_caballus_ENSECAP00000011833 RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT-ELESVDKSAGQA-ARNTGLLESQ--------------------------LSRH-----DQ M_domestica_ENSMODP00000016701 RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT-ELESVDKSAGQA-ARNTGLLETQ--------------------------LSRH-----DQ M_musculus_ENSMUSP00000021706 RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT-ELESVDKSAGQA-ARNTGLLESQ--------------------------LSRH-----DQ O_anatinus_ENSOANP00000023053 RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT-ELESVDKNAGQA-ARNTGMLETQ--------------------------LSRH-----DQ T_guttata_ENSTGUP00000013203 RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT-ELESVDKTAGQG-ARNTSLLETQ--------------------------LSRH-----DQ G_gallus_ENSGALP00000036699 RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT-ELESVDKTAGQG-ARNTSMLETQ--------------------------LSRH-----DQ A_carolinensis_ENSACAP00000000193 RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT-ELESVDKTAGQG-ARNAGLLESQ--------------------------LSRH-----DQ M_musculus_ENSMUSP00000082710 -ALTSHTDKSAWLEAQV-----------RQLLQIVNQQPSRLDLRSLVDAVDSVKQRIT-QLEAS--------DQRLVLLEGE--------------------------TSKH-----DA P_pygmaeus_ENSPPYP00000007003 RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT-ELESVDKSAGQV-ARNTGLLESQ--------------------------LSRH-----DQ P_troglodytes_ENSPTRP00000011503 RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT-ELESVDKSAGQV-ARNTGLLESQ--------------------------LSRH-----DQ H_sapiens_ENSP00000376500 RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT-ELESVDKSAGQV-ARNTGLLESQ--------------------------LSRH-----DQ E_caballus_ENSECAP00000005414 -LLASHLDKSAWLEAQV-----------RQLLQMANQQETKFDLRALMEAIDTVKQKIT-LLETH--------DQRIVVLEGE--------------------------TNKH-----DV P_troglodytes_ENSPTRP00000003288 -VFASHIDKSAWLEAQV-----------HQLLQMVNQQQNKFDLRPLMEAVDTVKQKIT-LLENN--------DQRLAVLEEE--------------------------TNKH-----DT P_pygmaeus_ENSPPYP00000000253 -VFASHIDKSAWLEAQV-----------HQLLQMVNQQQNKFDLRPLMEAVDTVKQKIT-LLENN--------DQRLAVLEEE--------------------------TNKH-----DT M_mulatta_ENSMMUP00000038268 -VFASHIDKSAWLEAQV-----------HQLLQMVNQQQNKFDLRPLMEAVDTVKQKIT-LLENN--------DQRLAVLEEE--------------------------TNKH-----DT H_sapiens_ENSP00000336825 -VFASHIDKSAWLEAQV-----------HQLLQMVNQQQNKFDLRPLMEAVDTVKQKIT-LLENN--------DQRLAVLEEE--------------------------TNKH-----DT T_guttata_ENSTGUP00000003276 -ALASHLDKSARLESQV-----------KQLIQMANQQQSKLDLQPLLDTIENVKQKIA-LMETY--------DQRLVVLEDQ--------------------------SSKH-----DL B_taurus_ENSBTAP00000015940 -VLASHIDKSAWLEVQV-----------RQLLQMANQQQSKFDLKPLVEAIDTVKQKIT-LLETN--------DQRLVVLEGE--------------------------TNKH-----DA D_rerio_ENSDARP00000014326 RSVEEQRVRICSVQREL---------------------------RDLRVLGSELKEELPRL------------QASLDSLRQQ-----------------------------------VA C_intestinalis_ENSCINP00000003143 -----------------------------------------------------------------------M-A--PENLSQM--------------------------VDAF-----ER G_gallus_ENSGALP00000016021 -TLASHLDKSARLESQV-----------KQLIQMANQQQSKLDLRPLFDTIENVKQKIA-LMETY--------DQRLAVLESQ--------------------------SSKH-----DL A_carolinensis_ENSACAP00000016112 -TLAIHIDKSACLETQV-----------RQLVQMANQQQSKFDLRPLLETVENIKQKVA-FLESY--------EQRLVVLEDL--------------------------SSQH-----DI M_domestica_ENSMODP00000003305 -VLASHIDKSAWLETQV-----------RELLELANQQENKLDLKPLINTIDTIKQKIT-LLETY--------DQRLVTLEGQ--------------------------TNRH-----DV C_intestinalis_ENSCINP00000001022 RMTAQQTDRSLALKKEVGDNDAANKRANTDLTQK---VE---EIAREIAQIKEKQNELERKIESTSSSREQM-A--PENLSQM--------------------------VDAF-----ER C_intestinalis_ENSCINP00000027890 RMTAQQTDRSLALKKEVGDNDAANKRANTDLTQK---VE---EIAREIAQIKEKQNELERNIESTSGSREQM-A--PENLSQM--------------------------VDAF-----ER M_mulatta_ENSMMUP00000015419 RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT-ELESVDKSAGQV-ARNTGLLESQ--------------------------LSRH-----DQ G_gallus_ENSGALP00000002401 NIVAV-------LNKEV-------------------------ETSNLEITAFRRQSELD--------------QNVIRGLELK--------------------------IAEL-----HH O_anatinus_ENSOANP00000013484 -ILANHIDKSTWLETQV-----------RQLLHMANQQQSKFDLKSLMETIDTVKQKIA-LLETY--------DQRLVVLKDQ--------------------------TRQH-----DA O_cuniculus_ENSOCUP00000007884 -XXXXXXXXXXXXXXXX-----------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXX--------XXXXXVLEGE--------------------------TSKH-----DA G_gorilla_ENSGGOP00000004192 RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT-ELESVDKSAGQV-ARNTGLLESQ--------------------------LSRH-----DQ C_familiaris_ENSCAFP00000017853 -VLANHIDKSAWLEAQV-----------RQLLQMANQQQNKFDLRPLVEAIDTVKQKIT-LLETN--------DQRLVVLEGE--------------------------TNKH-----DA T_rubripes_ENSTRUP00000047803 NIICV-------LNREV-------------------------ERSALKVEAFAHQHCLD--------------QEKIENLVSK--------------------------VGQL-----ER P_troglodytes_ENSPTRP00000036949 NIVCV-------LNREV-------------------------ERVAMTAEACSRQHRLD--------------QDKIEALSSK--------------------------VQQL-----ER P_pygmaeus_ENSPPYP00000022191 NIVCV-------LNREV-------------------------ERVAMTAEACSRQHRLD--------------QDKIEALSSK--------------------------VQQL-----ER T_nigroviridis_ENSTNIP00000011878 RIVCV-------LNREV-------------------------ERSTAMLEAFAHQHALD--------------QEKIENLSTK--------------------------LGQL-----ER T_nigroviridis_ENSTNIP00000016461 NVVCV-------LNREV-------------------------ERFATTMEASNRQHKLD--------------QDKIEALSNK--------------------------VRQL-----ER D_rerio_ENSDARP00000069217 NIVCV-------LNKEV-------------------------ERSALTMEAISRQHRLD--------------QEKIENLSNK--------------------------VRQL-----ER T_guttata_ENSTGUP00000006737 NIVAV-------LNKEV-------------------------ESSNLEIQAFRRQSELD--------------QNVIRGLELK--------------------------IAEL-----HQ O_cuniculus_ENSOCUP00000003184 XXXXXXXXXXXXXXXXX-----------XXXXXX---XX---XXXXXXXXXXXXXXXXX-XXXXXXXXXXXX-XXXXXLLESQ--------------------------LSRH-----DQ O_latipes_ENSORLP00000001368 ACLDEHRADILEMENEL-----------------LAAETLREHIGNQTGNSRSVKLRSA-TLCTGVFLFYIKCHLMSATLEEN--------------------------RKRH-----SG H_sapiens_ENSP00000247668 NIVCV-------LNREV-------------------------ERVAMTAEACSRQHRLD--------------QDKIEALSSK--------------------------VQQL-----ER T_nigroviridis_ENSTNIP00000013509 NIACV-------LNREV-------------------------ERSCTTMDAYNRQHRLD--------------QDKIEILNNK--------------------------VRQL-----ER M_musculus_ENSMUSP00000109872 NIVCV-------LNREV-------------------------ERVAVTAEACSRQHRLD--------------QDKIEALSNK--------------------------VQQL-----ER M_domestica_ENSMODP00000021625 NIVCV-------LNREV-------------------------ERVSMTAEACSRQHRLD--------------QEKIETLSSK--------------------------VQQL-----ER G_aculeatus_ENSGACP00000006974 NIACV-------LNREM-------------------------ERSCSTMEAYNRQHRLD--------------QDKIEILNNK--------------------------VRQL-----ER O_latipes_ENSORLP00000008989 NIVCV-------LNREV-------------------------ERSSLTLEAFSHQHRLD--------------QEKIENLSNK--------------------------IRQL-----ER G_gallus_ENSGALP00000014649 NIVCV-------LNREV-------------------------ERVSLTAEAYSRQHRLD--------------QEQIETLSNK--------------------------VRQL-----ER O_latipes_ENSORLP00000020860 NIVCI-------LNREL-------------------------ERSCATMEAYNRQHRLD--------------QDKIEILSNK--------------------------VRQL-----ER E_caballus_ENSECAP00000011150 NIVCV-------LNREV-------------------------ERVAMTAEACGRQHRLD--------------QDRIEALSNK--------------------------VQQL-----ER T_rubripes_ENSTRUP00000011363 NIVCV-------LNREV-------------------------ERSCTTMEAYNRQHRLD--------------QDKIEILNNK--------------------------VRQL-----ER B_taurus_ENSBTAP00000013869 NIVCV-------LNREV-------------------------ERVAVTAEACGRQHRLD--------------QDRIEALSNK--------------------------VQQL-----ER M_mulatta_ENSMMUP00000015132 NIVCV-------LNREV-------------------------ERVAMTAEACSRQHRLD--------------QDKIEALSNK--------------------------VQQL-----ER O_anatinus_ENSOANP00000001757 NIVAV-------LNKEV-------------------------ESSNMAIAASIHQSNLD--------------RDMILRLEQR--------------------------VLDL-----HQ X_tropicalis_ENSXETP00000008559 NIVSV-------LNREV-------------------------ERSSHAAEELARQLRAA--------------QEKVEALTTK--------------------------VRQL-----ER C_familiaris_ENSCAFP00000028895 NIVCV-------LNREV-------------------------ERVAMTAEACGRQHQLD--------------QDRIEALSNK--------------------------VQQL-----ER O_latipes_ENSORLP00000003220 NVVCV-------LNREV-------------------------ERFTTTMEASNRQHKLD--------------QDKIEALSNK--------------------------VRQL-----ER D_rerio_ENSDARP00000043465 NIVCV-------LNREM-------------------------ERSATTMEAYNRQHRLD--------------QDKIEILNNKIESNQGIKCEADNSCFSPRNYWMFVQVRQL-----ER G_aculeatus_ENSGACP00000022084 NIVCV-------LNREV-------------------------GRNSVTLEAFSHQHRLD--------------QEKIENLSNK--------------------------LLQL-----ER T_rubripes_ENSTRUP00000015632 NVVCV-------LNREV-------------------------ERFATTMEASNRQHKLD--------------QDKIEALSNK--------------------------VRQL-----ER C_elegans_F45G2.6 ----------------------------------------------------------------------------------------------------------------------MG D_rerio_ENSDARP00000091948 NIISA-------LNREV-------------------------EKTQISVVAMNRDHCNS--------------QQIIQHLEAT--------------------------VAEL-----QQ A_carolinensis_ENSACAP00000005007 GRLVRQDHQ-------------------------------------------------------------------IRELIAK--------------------------METQ-----NS E_caballus_ENSECAP00000009372 NIVAV-------LNKEV-------------------------EASHLALAASIHQSQLD--------------REHILSLEQR--------------------------VLEL-----QQ G_aculeatus_ENSGACP00000020860 NVVCV-------LNREV-------------------------ERFATAMEASNRQHKLD--------------QDKIEALSNK--------------------------VRQL-----ER D_rerio_ENSDARP00000036715 GRLVRQDQQ-------------------------------------------------------------------IRELCIH--------------------------NDTQ-----KN T_guttata_ENSTGUP00000002510 NIVCV-------LNREV-------------------------ERVSLTAEAYSRQHRLD--------------QEKIETLSNK--------------------------VRQL-----ER M_domestica_ENSMODP00000024498 NIVTV-------LNKEV-------------------------EASHLAIAASVHQSGLT--------------QDLILSLEQR--------------------------VVDL-----QQ T_guttata_ENSTGUP00000010462 GRLVRQDHQ-------------------------------------------------------------------IRELIAK--------------------------METQ-----NT O_anatinus_ENSOANP00000018657 GRLVRQDHQ-------------------------------------------------------------------IRELIAK--------------------------METQ-----SS X_tropicalis_ENSXETP00000031605 -TLASYIDKSMWLEEQV--------------IQLVSKEHSRLDLRPILDTLESTKQRLS-TLEAY--------KDRIDNLDGQ--------------------------FKKH-----DV H_sapiens_ENSP00000316840 GRLVRQDHQ-------------------------------------------------------------------IRELTAK--------------------------METQ-----SM P_pygmaeus_ENSPPYP00000003845 GRLVRQDHQ-------------------------------------------------------------------IRELTAK--------------------------METQ-----SM P_troglodytes_ENSPTRP00000006096 GRLVRQDHQ-------------------------------------------------------------------IRELTAK--------------------------METQ-----SM T_nigroviridis_ENSTNIP00000012472 RRLVKQDHQ-------------------------------------------------------------------LRELIIL--------------------------KENQ-----TG M_mulatta_ENSMMUP00000021907 GRLVRQDHQ-------------------------------------------------------------------IRELTAK--------------------------METQ-----ST B_taurus_ENSBTAP00000021630 GRLVRQDHQ-------------------------------------------------------------------IRELTAK--------------------------METQ-----SM C_familiaris_ENSCAFP00000010159 GRLVRQDHQ-------------------------------------------------------------------IRELTAK--------------------------METQ-----SM M_domestica_ENSMODP00000024756 SRLVIQDHQ-------------------------------------------------------------------IRELTAK--------------------------METQ-----SA R_norvegicus_ENSRNOP00000006148 GRLVRQDHQ-------------------------------------------------------------------IRELTAK--------------------------METQ-----SM G_aculeatus_ENSGACP00000022648 GRLVKQDHQ-------------------------------------------------------------------LRELIIL--------------------------KETQ-----AG T_rubripes_ENSTRUP00000041697 RRLVKQDHQ-------------------------------------------------------------------LRELIIL--------------------------KETQ-----AG M_musculus_ENSMUSP00000004949 SRLVRQDHQ-------------------------------------------------------------------IRELTAK--------------------------METQ-----SM G_gallus_ENSGALP00000012873 GRLVRQDHQ-------------------------------------------------------------------IRELIAK--------------------------METQ-----NT A_carolinensis_ENSACAP00000006987 -IIHY-------SNWIW-------------------------GRVRVTLPSF------------------------LPSLW-Q--------------------------VRQL-----ER X_tropicalis_ENSXETP00000016445 GRLVRQDHQ-------------------------------------------------------------------IRELIAK--------------------------METQ-----CT E_caballus_ENSECAP00000018618 GRLVRQDHQ-------------------------------------------------------------------IRELTAK--------------------------METQ-----SI O_cuniculus_ENSOCUP00000010330 GRLVRQDHQ-------------------------------------------------------------------IRELTAK--------------------------METQ-----SM R_norvegicus_ENSRNOP00000058607 NIVCV-------LNREV-------------------------ERVAVTAEACSRQHRLD--------------QDKIEALSNK--------------------------VQQL-----ER M_mulatta_ENSMMUP00000021905 DRLVGQDNQ-------------------------------------------------------------------IQELTDE--------------------------IETQ-----SI O_latipes_ENSORLP00000001290 PMLTRSDLELIIDSVKC-----------------------------------FKAQGFPSLVKCQNILKTPKTQFSLEWVLRH--------------------------KDRKSNHKLAG C_elegans_Y110A7A.2 ----------------------------------------------------------------------------------------------------------------------SA A_gambiae_AGAP003004-PA -------------------------------------------------------------------------YERIVILEQE--------------------------VHIL-----GI 730 740 750 760 770 780 790 800 810 820 830 840 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0111838 LSSRQGQQIQMLKSAVSK---------L-SINYTGTLLWKITDWS--AKMAEARGKDG--LELVSPPFYTSQYGYKLQASMFLNGNGPGE-NTHVSVYIKVLPGEYDALLKWPFSHS--- A_aegypti_AAEL006649-PA LSGRQGQQINMLKNAMAK---------L-STNYTGTLLWKITDWS--AKMVEAKSKDG--LELVSPPFYTSQYGYKLQASMFLNGNGPGE-GTHVSVYIKVLPGEYDALLKWPFSHS--- A_gambiae_AGAP010017-PA LSGRQGQQINMLKSAMAK---------L-STNYTGTLLWKITDWS--VKMQEAKTKDG--LELVSPPFYTSQYGYKLQASMFLNGNGPGE-GTHVSVYIKVLPGEYDALLKWPFSHS--- X_tropicalis_ENSXETP00000056667 LVSRQRQEILELRKQVEE---------L-SVSSEGVLIWKISDYS--RKVQEAKVRGN--FESFSPPFYTHKYGYKLQVSAFLNGNGSGE-GSYLSVYIRVLPGEYDNLLEWPFSYR--- M_musculus_ENSMUSP00000017530 LVSRQRQELQELRRELEE---------L-SIGSDGVLIWKIGSYG--RRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSIYIRVLPGAFDNLLEWPFARR--- R_norvegicus_ENSRNOP00000018468 LVSRQRQELQELRRELEE---------L-SVGSDGVLIWKIGSYG--RRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSIYIRVLPGAFDNLLEWPFARR--- P_troglodytes_ENSPTRP00000015252 LVSRQRQELQELRRELEE---------L-SVGSDGVLIWKIGSYG--RRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYIRVLPGAFDNLLEWPFARR--- P_pygmaeus_ENSPPYP00000009119 LVSRQRQELQELRRELEE---------L-SVGSDGVLIWKIGSYG--RRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYIRVLPGAFDNLLEWPFARR--- H_sapiens_ENSP00000262395 LVSRQRQELQELRRELEE---------L-SVGSDGVLIWKIGSYG--RRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYIRVLPGAFDNLLEWPFARR--- T_rubripes_ENSTRUP00000012878 LVGRQRQEILELRREMEE---------L-SVGHDGILIWKLNDYS--RKLQEAKIRSN--HEFFSPPFYTHRYGYKLQVSAFLNGNGSGE-GSHLSVYIRVLPGEYDNLLEWPFSYK--- B_taurus_ENSBTAP00000050075 LVSRQRQELQELRRELEE---------L-SVGSDGVLIWKIGSYG--RRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYIRVLPGAFDNLLEWPFARR--- B_taurus_ENSBTAP00000016271 LVSRQRQELQELRRELEE---------L-SVGSDGVLIWKIGSYG--RRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYIRVLPGAFDNLLEWPFARR--- E_caballus_ENSECAP00000009502 LVSRQRQELQELRRELEE---------L-SVGSDGVLIWKIGSYG--RRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYIRVLPGAFDNLLEWPFARR--- M_mulatta_ENSMMUP00000028200 LVSRQRQELQELRRELEE---------L-SVGSDGVLIWKIGSYG--RRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYIRVLPGAFDNLLEWPFARR--- G_aculeatus_ENSGACP00000014759 LVGRQRQEILELRREMEE---------L-SVSHDGVLIWKLSDYS--RKLQEAKLRSN--HEFFSPPFYTHRYGYKLQVSAFLNGNGSGE-GSHLSVYIRVLPGEYDSLLEWPFSYK--- O_latipes_ENSORLP00000005579 LVSRQRQEILELRREMEE---------L-SVSHDGVLIWKLNDYS--RKLQEAKLRSN--HEFFSPPFYTHRYGYKLQVSAFLNGNGSGE-GSHLSVYIRVLPGEYDNLLEWPFSYK--- M_domestica_ENSMODP00000024090 LVSRQRQELQELRRDVEE---------L-SVGCDGVLIWKIGGYG--RRLQEAKARAN--HECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYIRVLPGAFDNLLEWPFARR--- D_rerio_ENSDARP00000013849 LVGRQRQEILELRREMEE---------L-SVSHDGVLIWKLTDYS--RKLQEAKLRNN--HEFFSPPFYTHRYGYKLQVSAFLNGNGSGE-GSHLSIYIRVLPGEYDNLLEWPFSYK--- D_rerio_ENSDARP00000056877 LVNRQRLELRDLRRRMEE---------L-SGSRDGTLLWKLTDFS--QRLQEAKTRTSGCLELFSPAFYSHNYGYRLQVSAFLNGNGSGE-DTHMSVYLRVLPGEYDGLLEWPFPYR--- O_cuniculus_ENSOCUP00000000748 LVSRQRQELQELRRELEE---------L-SVGSDGVLIWKIGSYG--RRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYIRVLPGAFDNLLEWPFARR--- T_nigroviridis_ENSTNIP00000019321 LVGRQRQEILELRREMEE---------L-SVSHDGILIWKLNDYS--RKLQEAKIRSN--HEFFSPPFYTHRYGYKLQVSAFLNGNGSGE-GSHLSVYIRVLPGEYDNLLEWPFSYK--- G_gorilla_ENSGGOP00000016344 LVSRQRQELQELRRELEE---------L-SVGSDGVLIWKIGSYG--RRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYIRVLPGAFDNLLEWPFARR--- C_intestinalis_ENSCINP00000008928 LVKTQRSHISELQKQLSD---------L-TVNTNGTLLWKIPGYS--QKLQAAQKDQA--IEMRSPPFYTHRYGYKLQLSAFLNGNGSGL-NSHMSLY---------------------- C_familiaris_ENSCAFP00000027741 AATGLLSALYLPRSELGT---------C-SSPREPPWAWSAYEASGTKGANGKEEDQN--IRA-----FVSCYGYII----ILENPITPI-NHHSSLYIRVLPGAFDNLLEWPFARR--- O_anatinus_ENSOANP00000019424 LVSRQRQELQELRRDVEE---------L-AAGSDGVLVWRIGGYG--RRLQEARGRPN--HECLSRPFYTHKYGYRLQVSAFLNGNGSGE-GTHLSLYIRVLPGDYDNLLEWPFALR--- C_intestinalis_ENSCINP00000003738 LLGLQKKQLFEHKQILHDHGKMVRNGIFSNIEFDSQLLWKISEWS--SKKIEAEAGKR--TVLQSPLFYSARFQYKLAVLLLPNGDGKAK-GTHLSIYVRLCKGEYDALLSWPYRLP--- M_mulatta_ENSMMUP00000022296 LLIWQWQELQDLQQELED---------L-SVGSDGVLIWKTGSCG--QWLQEAKAKPN--LECFSPAFYTQKCGYKLQVSAFLNDKGSGE-GTRLSLYIDLLPGAFDNLLEWSFAPC--- T_nigroviridis_ENSTNIP00000005138 MLSVHDIRLADMDLRFQV---------LETASYNGTLIWKIRDYK--RRKQEAVAAKT--LSLYSQPFYTGYFGYKMCARIYLNGDGMGK-GTHLSLFFVVMRGEYDALLPWPFKQK--- T_rubripes_ENSTRUP00000013348 MLSVHDIRLADMDLRFQV---------LETASYNGTLIWKIRDYK--RRKQEAVAAKT--LSLYSQPFYTGYFGYKMCARIYLNGDGMGK-GTHLSLFFVVMRGEYDALLPWPFKQK--- G_aculeatus_ENSGACP00000005703 MLSVHEIRLADMDLRFQV---------LETASYNGTLIWKIRDYK--RRKQEAVGAKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVVMRGEYDALLPWPFKQK--- B_taurus_ENSBTAP00000017918 MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- R_norvegicus_ENSRNOP00000010906 MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- C_familiaris_ENSCAFP00000026713 MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- X_tropicalis_ENSXETP00000027864 MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- D_rerio_ENSDARP00000038596 LMSVHDVRLAEMDLKLQV---------LETASFNGTLIWKIRDYK--RRKQEAVVSKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVVMRGEYDALLQWPFKQK--- E_caballus_ENSECAP00000011833 MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- M_domestica_ENSMODP00000016701 MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- M_musculus_ENSMUSP00000021706 MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- O_anatinus_ENSOANP00000023053 MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- T_guttata_ENSTGUP00000013203 MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- G_gallus_ENSGALP00000036699 MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- A_carolinensis_ENSACAP00000000193 MLSVHDIRLADMDLRFQV---------LETASYNGILIWKIRDYK--RRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- M_musculus_ENSMUSP00000082710 HINIHKAQLNKNEERFKQ---------LEGACYSGKLIWKVTDYR--VKKREAVEGHT--VSVFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYFVVMRGEFDSLLQWPFRQR--- P_pygmaeus_ENSPPYP00000007003 MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- P_troglodytes_ENSPTRP00000011503 MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- H_sapiens_ENSP00000376500 MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- E_caballus_ENSECAP00000005414 HINIHKAQLNKNEERFKL---------LEGACYNGKLIWKVTDYK--MKKREALEGHT--VSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYFVVMRGEFDSLLQWPFRQR--- P_troglodytes_ENSPTRP00000003288 HINIHKAQLSKNEERFKL---------LEGTCYNGKLIWKVTDYK--MKKREAVDGHT--VSIFSQSFYTSRCGYRLCARAYLNGDGSGR-GTHLSLYFVVMRGEFDSLLQWPFRQR--- P_pygmaeus_ENSPPYP00000000253 HINIHKAQLSKNEERFKL---------LEGTCYNGKLIWKVTDYK--MKKREAVDGHT--VSIFSQSFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYFVVMRGEFDSLLQWPFRQR--- M_mulatta_ENSMMUP00000038268 HINIHKAQLNKNEERFKL---------LEGTCYNGKLIWKVTDYK--MKKREAVDGHT--VSIFSQSFYTGRCGYRLCARAYLNGDGSGK-GTHLSLYFVVMRGEFDSLLQWPFRQR--- H_sapiens_ENSP00000336825 HINIHKAQLSKNEERFKL---------LEGTCYNGKLIWKVTDYK--MKKREAVDGHT--VSIFSQSFYTSRCGYRLCARAYLNGDGSGR-GSHLSLYFVVMRGEFDSLLQWPFRQR--- T_guttata_ENSTGUP00000003276 QINIHKAQLNKNEERFKL---------LEGTCYNGKLIWKITDYQ--KKKREAVEGRV--LSIASQPFYTSRCGYRLCARAYLNGDGSGK-GTHISLYFVVMRGEFDSLLLWPFKQK--- B_taurus_ENSBTAP00000015940 HINIHKAQLNKNEERFKL---------LESACYNGKLIWKVTDYK--LKKKEALDGHT--VSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYFVVMRGEFDSLLQWPFRQR--- D_rerio_ENSDARP00000014326 VTESLREHLVALKQHSTF---------LESSSYDGKLIWKVRDYW--HRKESG-------AALSSSPFYTSRSGYKLSVRAYLGGDGSGR-GSHMSLYITIMRGDFDSFLPWPFRQN--- C_intestinalis_ENSCINP00000003143 QLGMYDVRIADMDQRFQV---------IETTSYSGVVIWKIRDFS--RRKREAVSGRT--LSLYSQPFYTSRYGYKMCARVYLNGDGMGK-GTHMSLFFVVMKGEYDALLPWPFRQK--- G_gallus_ENSGALP00000016021 QINIHKAQLNKNEERFKL---------LEGTCYNGKLIWKITDYK--MKKKEAVEGRV--LSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHVSLYFVVMRGEFDSLLPWPFKQK--- A_carolinensis_ENSACAP00000016112 HLGLHKAQLNKNEERFKL---------LEGTSYNGKLIWKIVDYK--TKKKEAVEGSC--LSIFSQPFYTSRCGYRLSTRAYLNGDGSGK-GTHVSLYFVVMRGEFDSLLPWPFRQK--- M_domestica_ENSMODP00000003305 HINVHKAQLNKNEERFKM---------LEGTCYNGKLIWKVTDYK--MKKKEATEGRT--VSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYFVVMKGEFDSLLQWPFKQR--- C_intestinalis_ENSCINP00000001022 QLGMYDVRIADMDQRFQV---------LETTSYSGVVIWKIRDFS--RRKREAVSGRT--LSLYSQPFYTSRYGYKMCARVYLNGDGMGK-GTHMSLFFVVMKGEYDALLPWPFRQK--- C_intestinalis_ENSCINP00000027890 QLGMYDVRIADMDQRFQV---------IETTSYSGVVIWKIRDFS--RRKREAVSGRT--LSLYSQPFYTSRYGYKMCARVYLNGDGMGK-GTHMSLFFVVMKGEYDALLPWPFRQK--- M_mulatta_ENSMMUP00000015419 MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- G_gallus_ENSGALP00000002401 CLTQKDAGLSRLHKSLVF---------SEQTSYDGVFLWKITDVN--QKLQDSVTGRV--VSLYSPAFYTAKYGYKVCLRIYLNGDGMGK-GTHVSLFFVVMKGDYDALLPWPFRHK--- O_anatinus_ENSOANP00000013484 HINAHKAQLNKNEERFKL---------LEGTCYNGKLIWKVTDYK--MKKREAMEGRS--VSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYFVVMKGEFDSLLQWPFKQK--- O_cuniculus_ENSOCUP00000007884 HINIHKAQLNKNEERFKL---------LEGACYNGKLIWKVTDYK--MKKKEAVDGHT--VSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYFVVMRGEFDSLLQWPFRQR--- G_gorilla_ENSGGOP00000004192 MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- C_familiaris_ENSCAFP00000017853 HINIHKAQLNKNEERFKL---------LEGACYNGKLIWKVTDYK--MKKREALDGHT--VSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYFVVMRGEFDSLLQWPFRQR--- T_rubripes_ENSTRUP00000047803 AIAMRDLQLSETEQMVRE---------LQSCTYDGIFVWKISEFS--RRRQEAVAVRM--PTMFSPAFYSSKYGYKMCLRLYLNGDGTGR-GTHLSLFFVVMRGKCDALLKWPFSQK--- P_troglodytes_ENSPTRP00000036949 SIGLKDLAMADLEQKVLE---------MEASTYDGVFIWKISDFA--RKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLRIYLNGDGTGR-GTHLSLFFVVMKGPNDALLRWPFNQK--- P_pygmaeus_ENSPPYP00000022191 SIGLKDLAMADLEQKVLE---------MEASTYDGVFIWKISDFA--RKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLRIYLNGDGTGR-GTHLSLFFVVMKGPNDALLRWPFNQK--- T_nigroviridis_ENSTNIP00000011878 VIAMRDLQLSETEQMVRE---------LQSCTYDGIFVWKISEFS--RRRQEAVAGRT--PAMFSPAFYSSKYGYKMCLRLYLNGDGTGR-GTHLSLFFVVMKGKCDALLKWPFSQK--- T_nigroviridis_ENSTNIP00000016461 TVGLKDLTVAEMEGRLRE---------MSATTFDGVFVWRISDFA--KKRQDAIAGRA--PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GSHLSLFFVVMRGQSDALLKWPFNQK--- D_rerio_ENSDARP00000069217 TLTTRDLQLAESEQSLRE---------LQFCTYDGVFIWKIAEFS--RRRQDAVAGRA--PAMFSPAFYSSKYGYKMCLRLYLNGDGTGR-GSHLSLFFVVMKGKYDALLKWPFSQK--- T_guttata_ENSTGUP00000006737 CLTQKDAGLSSLHKSLLF---------SEQASYDGIFLWKITEVA--RKLQDSVTGRT--VSLYSPAFYTAKYGYKVCLRVYLNGDGTGK-GTHMSLFFVVMKGDYDALLPWPFRHK--- O_cuniculus_ENSOCUP00000003184 MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- O_latipes_ENSORLP00000001368 LLELHVAQLALNKQHLQE---------LELTSYDGRLIWKIKDFQ--KRREAEATGQH--PCLSSVPFHTGRCGYKMAMKAYLNGDGEGR-GTHLSLYVVLMPGDFDALLPWPFKQT--- H_sapiens_ENSP00000247668 SIGLKDLAMADLEQKVLE---------MEASTYDGVFIWKISDFA--RKRQEAVAGRI--PAIFSPAFYTSRYGYKMCLRIYLNGDGTGR-GTHLSLFFVVMKGPNDALLRWPFNQK--- T_nigroviridis_ENSTNIP00000013509 TVSLRDLSIVEMDEKMRE---------LSAATYDGVFVWKIADFT--KKRQDAVAGRA--PAMFSPAFYTSKYGYKMC-RIYLNGDGTGR-GSHLSLFFVVMRGHSDALLKWPFNQK--- M_musculus_ENSMUSP00000109872 SIGLKDLAMADLEQKVSE---------LEVSTYDGVFIWKISDFT--RKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLRVYLNGDGTGR-GTHLSLFFVVMKGPNDALLQWPFNQK--- M_domestica_ENSMODP00000021625 SIGLKDLAMADMEQKILE---------MEASTYDGIFIWKITDFA--RKRQEAMAGRS--PAIFSPAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFFVVMKGPNDALLRWPFNQK--- G_aculeatus_ENSGACP00000006974 TVSLRDLSIVEMEGKMRD---------MSAATYDGIFVWKISDFT--KKRQDAVAGRA--PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFFVVMRGHSDALLKWPFNQK--- O_latipes_ENSORLP00000008989 SLTVKDLQLSEAEQMVRE---------LQYCTYDGIFVWKITDFS--HRRQEAVSGRA--PAMFSPAFYSSKYGYKMCLRLYLNGDGTGR-GTHLSLFFVVMRSKYDALLKWPFSQK--- G_gallus_ENSGALP00000014649 SIGLKDLAMAEMEEKIRN---------MEASTYDGVFIWKITEFA--RKRQEAITGRS--PAIFSPAFYTSKYGYKMCLRVYLNGDGTGR-GTHLSLFFVVMKGPNDALLRWPFNQK--- O_latipes_ENSORLP00000020860 TVSLRDLSIVEMEGKMKD---------MSAATYDGIFIWKISDFT--KKRQDAMAGRA--PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFFVVMRGHSDALLKWPFNQK--- E_caballus_ENSECAP00000011150 SIGLKDLAMADLEQKVHE---------MEASTFDGVFIWKISDFT--RKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLRIYLNGDGTGR-GTHVSLFFVVMKGPNDALLRWPFNQK--- T_rubripes_ENSTRUP00000011363 TVSLRDLSIVEIDEKMRE---------LSAATYDGVFVWKISDFT--KKRQDAVAGRA--PAMFSSAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFFVVMRGHSDALLKWPFNQK--- B_taurus_ENSBTAP00000013869 SIGLKDLAMADLEQKVLE---------MEASTFDGVFIWKISDFS--RKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLRAYLNGDGTGR-GTHLSLFFVLMRGPHDALLRWPFNQK--- M_mulatta_ENSMMUP00000015132 SIGLKDLAMADLEQKVLE---------MEASTYDGVFIWKISDFA--RKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLRIYLNGDGTGR-GTHLSLFFVVMKGPNDALLRWPFNQK--- O_anatinus_ENSOANP00000001757 TLAQKDLALARLKQSLQF---------SELASYDGIYLWKITDFS--RKCHESLCGRT--TSLFSPVFYTARYGYKVCLRVYLNGDGTGK-GTHISLFFVIMKGEYDSLLQWPFRNK--- X_tropicalis_ENSXETP00000008559 TLGQKELIVAELETRMQE---------SELSTYDGVFIWKISEFG--KKRQDAINGRC--PAMFSPPFYTNKYGYKMCLRIYLNGDGTGR-NTHLSLFFVVMKGNNDALLRWPFNQK--- C_familiaris_ENSCAFP00000028895 TIGLKDLAMAELEQKVHE---------MEASTFDGVFIWKISDFA--RKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLRIYLNGDGTGR-GTHLSLFFVVMKGPNDALLRWPFNQK--- O_latipes_ENSORLP00000003220 TVGLKDLTVAEMEGRLRE---------MAATTFDGVFIWRISDFA--KKRQDAVAGRA--PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFFVVMRGLSDALLKWPFNQK--- D_rerio_ENSDARP00000043465 TVGLRDLSIVEMEAKMRE---------MSAATYDGVFVWKISDFS--KKRQDAVAGRA--PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFFVVMRGHSDALLKWPFNQK--- G_aculeatus_ENSGACP00000022084 TVSMKDLQLSATDQLLKE---------LQFCTYDGIFVWKISDFS--RRRQDAVAGRT--PAMFSPAFYSSKYGYKMCLRLYLNGDGTGR-GTHLSLFFVVMRGKCDALLKWPFSQK--- T_rubripes_ENSTRUP00000015632 TVGLKDLTVAEMEGRLRE---------MSATTFDGVFVWRISDFA--KKRQDAIAGRA--PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GSHLSLFFVVMRGQSDALLKWPFNQK--- C_elegans_F45G2.6 SFNDRQTRILSAAETCTE-------------MFGPQLIWKIDKLQ--QRTNEAKSGAD--TTIFSVPFMSHRFGYKMMACACLFGDGSSA-GKSISLYVLLLKGEFDPTLEWPFHRA--- D_rerio_ENSDARP00000091948 RLVRKDILISSLQQSISA---------QQDVSYDGTFYWRVCDVS--QKQREAANSQK--ISQYSPAFYTARYGFKVCLRLYLNGDGAGK-GSHISLFFVIMKGEYDPILSWPFKHK--- A_carolinensis_ENSACAP00000005007 QVGDLKGTIKNLEEKITE---------LEAQQCNGIFIWKIEHFS--VYLKALEEERP--VVIHSPGFYTGKPGYKLCMRLHIQLPNVQRCANYISLFVHIMQGEYDNYLPWPFQGT--- E_caballus_ENSECAP00000009372 TLAQKDQALGKLEQSLRL---------MEEASFDGTFLWKITNVT--RRCHESACGRT--VSLFSPAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFIVIMRGEYDALLPWPFRNK--- G_aculeatus_ENSGACP00000020860 TVGLKDLTVAEMEGRLRE---------MSATTFDGVFVWRISDFA--KKRQDAIAGRA--PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GSHLSLFFVVMRGLSDALLKWPFNQK--- D_rerio_ENSDARP00000036715 QVTELRRKLVSLEESTRE---------LEAQQYQGIYVWRVENFS--HHLRNQEAGQP--IVLHSPPFYTGRPGYKLCLRLHLQTPSAPRCSNFISLFVHTMQGEFDSQLSWPLQGT--- T_guttata_ENSTGUP00000002510 SIGLKDLAMAEMEEKIRN---------MEASTYDGVFIWKITEFA--RKRQEAITGRS--PAIFSPAFYTSKYGYKMCLRVYLNGDGTGR-GTHLSLFFVVMKGPNDALLRWPFNQK--- M_domestica_ENSMODP00000024498 TLTQKDLALTKLEQTLHL---------LEEASYDGVYLWKITNFT--RRCHESACGRT--VSLFSPAFYTARYGYKLCLRIYLNGDGMGK-GTHLSLFIVVMKGKYDALLEWPFRNKAIP T_guttata_ENSTGUP00000010462 HMAELKRTIRNLEGKITE---------MEAQQCNGIYIWKIENFS--GLQRAQEEERP--VVLHSPGFYTGKPGYKLCLRLHIQLPNAQRCANFISLFVHTMQGEYDSHLPWPFQGT--- O_anatinus_ENSOANP00000018657 HVVDLKRTIRTLEDKIAE---------MEAQQCNGIYIWKIGNFG--MHLKSQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPNAQRCANYISLFVHTMQGEYDSHLPWPFQGT--- X_tropicalis_ENSXETP00000031605 LLSNHKMQMTSNEERFRL---------VEGTSYNGKLIWKITDYE--RKKREAMEGRA--VSIFSQHFYTSWCGYRLCARAYLNGDGSGK-GSFLSLYFVVMKGEFDSILLWPFKQK--- H_sapiens_ENSP00000316840 YVSELKRTIRTLEDKVAE---------IEAQQCNGIYIWKIGNFG--MHLKCQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGT--- P_pygmaeus_ENSPPYP00000003845 YVSELKRTIRTLEDKVAE---------IEAQQCNGIYIWKIGNFG--MHLKCQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGT--- P_troglodytes_ENSPTRP00000006096 YVSELKRTIRTLEDKVAE---------IEAQQCNGIYIWKIGNFG--MHLKCQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGT--- T_nigroviridis_ENSTNIP00000012472 QIAELRKRVSVLEESMRE---------LESQHCTGIYIWRLKDFS--VLLRNQEAGLP--VVEHSPGFYTGRPGYKLCLRLHLQSPVAQRCSNFISLFVHTMQGAYDGLLTWPFQGT--- M_mulatta_ENSMMUP00000021907 YVSELKRTIRTLEDKVAE---------IEAQQCNGIYIWKIGNFG--MHLKCQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGT--- B_taurus_ENSBTAP00000021630 YVNELKRTIRTLEDKVAE---------IEAQQCNGIYIWKIGNFG--MHLKSQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPSAQRCANYISLFVHTMQGEYDSHLPWPFQGT--- C_familiaris_ENSCAFP00000010159 HVSELKRNIRTLEDKVAE---------IEAQQCNGIYIWKIGNFG--MHLKSQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGT--- M_domestica_ENSMODP00000024756 CVGDLKRTIRTLEDRIAE---------MEAQQCNGIYIWKINNFG--MHLKSQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPSAQRCANYISLFVHTMQGEYDSHLPWPFQGT--- R_norvegicus_ENSRNOP00000006148 HVSELKRTIRSLEDKVAE---------MEAQQCNGIYIWKIGNFG--MHLKSQEEERP--VVIHSPGFYTGRPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGT--- G_aculeatus_ENSGACP00000022648 QLAELRRRVSLLEDTVKE---------LESQQCHGIFIWRLRGFS--AHLRNQEAGQP--VVEHSPGFYTGRPGYKLCLRLHLQTPNAPRCSNFISLFVHTMQGAFDGQLSWPFQGT--- T_rubripes_ENSTRUP00000041697 QLAELGRRVSMLEETVRE---------LESQHCTGIFIWRLKDFS--VLLRNQEAGLP--VVEHSPAFYTGRPGYKLCLRLHLQSPNAQRCSNFISLFVHTMQGAFDGRLTWPFQGT--- M_musculus_ENSMUSP00000004949 YVGELKRTIRTLEDKVAE---------MEAQQCNGIYIWKIGNFG--MHLKSQEEERP--VVIHSPGFYTGRPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGT--- G_gallus_ENSGALP00000012873 HMAELKRTIRDLEGKITE---------MEAQQCNGIYIWKIENFS--GLQKAQEEERP--VVMHSPGFYTGKPGYKLCLRLHIQLPSAQRCANFISLFVHTMQGEYDSHLPWPFQGT--- A_carolinensis_ENSACAP00000006987 SLASKDLALAEMEHSLQE---------MEAASFDGIFIWKISDFT--KKRQ-AVAGRS--PAIFSPAFYTGKYGYKMCLRIYLNGDGTGR-GTHLSLFFVVMRGPCDALLRWPFNQK--- X_tropicalis_ENSXETP00000016445 YVNELKHTIRSLDNRLGE---------MESQQCSGIFIWRINNFN--SLLKNQEEERP--VVIHSQGFYTGKPGYKLCLRLHLQLPSAQRCANYISLFVHTMQGEYDSLLPWPLQGT--- E_caballus_ENSECAP00000018618 YVSELKRTIRTLEDKVAE---------IEAQQCNGIYIWKIGNFG--MHLKSQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGT--- O_cuniculus_ENSOCUP00000010330 YVSELKRTIRTLEDKVAE---------IEAQQCNGIYIWKIGNFG--MHLKSQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGT--- R_norvegicus_ENSRNOP00000058607 SIGLKDLAMADLEQKVSE---------LEVSTYDGVFIWKISDFA--RKRQEAIAGRT--PAIFSPGAVCVLRMLLMLLNVYLQGRGTGR-QTHLSQLSVCARAYWAVVLQWLLTEQ--- M_mulatta_ENSMMUP00000021905 YVSE----IRTLEDKVAD---------IEAQQCNGIYIWKIGS-----HLKCQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLLTAQRCANYISLFVHTMQGEYDSHLPWPF-GT--- O_latipes_ENSORLP00000001290 QLAELRRRVSVLEETVKE---------LEAQQYHGIFIWRLKAFS--THLRSQEAGIP--VVEHSPGFYTGRPGYKLCLRLHLQTPTAPRCSNFISLFVHTMQGVFDSQLTWPFQGT--- C_elegans_Y110A7A.2 YVDKYVGMLQYM--SIAE---------SAFEKYGSQHTFRIPKIG--LTVVKATKNKS-HRSIYSQPFYSHGYGYKMMAVAAPYGDGLAF-REYFSVFVCLMKGEWDDILEWPFRCD--- A_gambiae_AGAP003004-PA KLSKQEIQLTKLNQ---E---------VDPRYSGGVLLWKLDDFS--NKIESMVANSN--CMFYSSEAYTSPHGYKFCARINVS----PRTKDSIGLHVHLMQSENDYHLEWPFKGR--- 850 860 870 880 890 900 910 920 930 940 950 960 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0111838 ITFTLFEQG--AQSG--QGGVAESFVPD--PTWEN---FQRP----------S-NEP--DQL-GFGFPRFISHELLHSR---PFIKGDTVFL---RVKVD-PSKIV-------------- A_aegypti_AAEL006649-PA VTFTLFEQGTLGS----QGGVAESFVPD--PSWEN---FQRP----------S-TEP--DAL-GFGFPRFVSHELLNRR---PFVREDTVFL---RVKVD-PSKIV-------------- A_gambiae_AGAP010017-PA VTFTLFEQGTLGSGGGGQGGVAESFVPD--PTWEN---FQRP----------S-TEP--DAL-GFGFPRFVSHELLNRR---PFVRDDTVFL---RVKVD-PSKIV-------------- X_tropicalis_ENSXETP00000056667 VTFSLLDQSDPSLSK--PQHITETFNPD--PNWKN---FQKP-----TGSRNS-LDE--STL-GFGYPKFISHEDIRKR---NYVRDNAIFL---RASVEIPQKII-------------- M_musculus_ENSMUSP00000017530 VTFSLLDQSDPGLAK--PQHVTETFHPD--PNWKN---FQKP-----GTWRGS-LDE--SSL-GFGYPKFISHQDIRKR---NYVRDDAVFI---RASVELPRKIL-------------- R_norvegicus_ENSRNOP00000018468 VTFSLLDQSDPGLAK--PQHVTETFHPD--PNWKN---FQKP-----GTWRGS-LDE--SSL-GFGYPKFISHQDIRKR---NYVRDDAVFI---RASVELPRKIL-------------- P_troglodytes_ENSPTRP00000015252 VTFSLLDQSDPGLAK--PQHVTETFHPD--PNWKN---FQKP-----GTWRGS-LDE--SSL-GFGYPKFISHQDIRKR---NYVRDDAVFI---RAAVELPRKIL-------------- P_pygmaeus_ENSPPYP00000009119 VTFSLLDQSDPGLAK--PQHVTETFHPD--PNWKN---FQKP-----GTWRGS-LDE--SSL-GFGYPKFISHQDIRKR---NYVRDDAVFI---RAAVELPRKIL-------------- H_sapiens_ENSP00000262395 VTFSLLDQSDPGLAK--PQHVTETFHPD--PNWKN---FQKP-----GTWRGS-LDE--SSL-GFGYPKFISHQDIRKR---NYVRDDAVFI---RAAVELPRKIL-------------- T_rubripes_ENSTRUP00000012878 VTFSLLDQSDPSLSK--PQHITETFNPD--PNWKN---FQKP-----SSTRNS-LDE--STL-GFGYPKFISHEEIKKR---NYVRDNCIFI---KASIEIPQKIM-------------- B_taurus_ENSBTAP00000050075 VTFSLLDQSDPGLAK--PQHVTETFHPD--PNWKN---FQKP-----GTWRGS-LDE--SSL-GFGYPKFISHQDIRKR---NYVRDDAVFI---RASVELPRKIL-------------- B_taurus_ENSBTAP00000016271 VTFSLLDQSDPGLAK--PQHVTETFHPD--PNWKN---FQKP-----GTWRGS-LDE--SSL-GFGYPKFISHQDIRKR---NYVRDDAVFI---RASVELPRKIL-------------- E_caballus_ENSECAP00000009502 VTFSLLDQSDPGLAK--PQHVTETFHPD--PNWKN---FQKP-----GTWRGS-LDE--SSL-GFGYPKFISHQDIRKR---NYVRDDAVFI---RASVELPRKIL-------------- M_mulatta_ENSMMUP00000028200 VTFSLLDQSDPGLAK--PQHVTETFHPD--PNWKN---FQKP-----GTWRGS-LDE--SSL-GFGYPKFISHQDIRKR---NYVRDDAVFI---RAAVELPRKIL-------------- G_aculeatus_ENSGACP00000014759 VTFSILDQSDPSLSK--PQHITETFNPD--PNWKN---FQKP-----SSSRNS-LDE--STL-GFGYPKFISHDEIKKR---NYIRDNCVFI---KASIEIPQKIM-------------- O_latipes_ENSORLP00000005579 VTFSILDQSDPSLSK--PQHITETFNPD--PNWKN---FQKP-----CSTRNS-LDE--STL-GFGYPKFISHEEIKKR---NYIRDNCIFI---KASIEIPQKIM-------------- M_domestica_ENSMODP00000024090 VTFSLLDQSDPAVAK--PQHVTETFHPD--PHWKN---FQKP-----GTWRGS-MDE--SAL-GFGYPKFISHQDIRKR---NYVRDDAVFI---RASVELPKKIL-------------- D_rerio_ENSDARP00000013849 VTFSILDQSDPSLSK--PQHITETFNPD--PNWKN---FQKP-----CSSRNS-LDE--STL-GFGYPKFISHEEIKKR---NYIRDNSIFL---KASIEIPQKIM-------------- D_rerio_ENSDARP00000056877 VSFSLLDQCDPALTK--PQHITETFSPD--PTWKN---FQRPRPGALGSIRGGCLDE--SML-GFGYPKFISHEEMKKR---NYIRDNAVFI---KASIDVVQKIL-------------- O_cuniculus_ENSOCUP00000000748 VTFSLLDQSDSGWAR--PQHVTETFHAD--SNWEE--AFQKP-----GTWRGS-LDE--SSL-GF------------------------------------------------------- T_nigroviridis_ENSTNIP00000019321 VTFSLLDQSDPSLSK--PQHITETFNPD--PNWKN---FQKP-----NSTRNS-LDE--STL-GFGYPKFISHEEIKKR---NYIRDNCIFI---KASIEIPQKIM-------------- G_gorilla_ENSGGOP00000016344 VTFSLLDQSDPGLAK--PQHVTETFHPD--PNWKN---FQKP-----GTWRGS-LDE--SSL-GFGYPKFISHQDIRKR---NYVRDDAVFI---RAAVELPRKIL-------------- C_intestinalis_ENSCINP00000008928 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000027741 VTFSLLDQSDPGLAK--PQHVTETFHPD--PNWKN---FQKP-----GTWRGS-LDE--SSL-GFGYPKFISHQDIRKR---NYVRDDAVFI---RASVELPRKIL-------------- O_anatinus_ENSOANP00000019424 VTFSLLDQSDPSLSK--PQHVTETFHPD--PHWKN---FQKP-----GAWRGS-GSS-GAAL-GFGYPKFISHEDIRKR---DYVRDDAVFI---RAAVELPRRIL-------------- C_intestinalis_ENSCINP00000003738 IEISLIDQSQDPRA---RINHTYSLRPN--PCKENKPFLGRP------------TSE--SNP-SFGSQTFMPLDTLNTR---DYIRDDAIFI---RVSVLHDET---------------- M_mulatta_ENSMMUP00000022296 VTFCLLDQSDPGLAK--PQHITDTFHPG--PNWKN---FQKP-----GTWEGS-LDE--SSL-GFGYLKFISHQDIQKR---KSYSQNCVFVTWGKCFSILKKKFL-------------- T_nigroviridis_ENSTNIP00000005138 VTLMLMDQGPL------KKHLGDAFKPD--PNSSS---FRRP------------VVE--MNI-ASGCPLFVSQSVLETG---SYIKDDTIFI---KVTVD-TSDLP-------------- T_rubripes_ENSTRUP00000013348 VTLMLMDQGPL------KKHLGDAFKPD--PNSSS---FRRP------------VVE--MNI-ASGCPLFVSQSVLETG---SYIKDDTIFI---KVTVD-TSDLP-------------- G_aculeatus_ENSGACP00000005703 VTLMLMDQGPL------RKHLGDAFKPD--PNSSS---FRRP------------AAE--MNI-ASGCPLFVSQSVLETG---TYIKDDTIFI---KVTVD-TSDLP-------------- B_taurus_ENSBTAP00000017918 VTLMLMDQGSS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--MNI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- R_norvegicus_ENSRNOP00000010906 VTLMLMDQGSS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--MNI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- C_familiaris_ENSCAFP00000026713 VTLMLMDQGSS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--MNI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- X_tropicalis_ENSXETP00000027864 VSLMLMDQGPS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--MNI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- D_rerio_ENSDARP00000038596 VTLMLMDQGPA------RKHLGDAFKPD--PSSSS---FRRP------------TGE--MNI-ASGCPLFVAQTVLENG---TYIKDDTIFI---KVTVD-TSDLP-------------- E_caballus_ENSECAP00000011833 VTLMLMDQGSS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--MNI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- M_domestica_ENSMODP00000016701 VTLMLMDQGSS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--MNI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- M_musculus_ENSMUSP00000021706 VTLMLMDQGSS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--MNI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- O_anatinus_ENSOANP00000023053 VTLMLMDQGSS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--MNI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- T_guttata_ENSTGUP00000013203 VTLMLMDQGPS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--MNI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- G_gallus_ENSGALP00000036699 VTLMLMDQGPS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--MNI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- A_carolinensis_ENSACAP00000000193 VTLMLMDQGPS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--MNI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- M_musculus_ENSMUSP00000082710 VTLMLLDQSGK------KNHIVETFKAD--PNSSS---FKRP------------DGE--MNI-ASGCPRFVSHSTLENSKN-TYIKDDTLFL---KVAVD-LTDLE-------------- P_pygmaeus_ENSPPYP00000007003 VTLMLMDQGSS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--MNI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- P_troglodytes_ENSPTRP00000011503 VTLMLMDQGSS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--MNI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- H_sapiens_ENSP00000376500 VTLMLMDQGSS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--MNI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- E_caballus_ENSECAP00000005414 VTLMLLDQSGK------KNHIMETFKAD--PNSSS---FKRP------------DGE--MNI-ASGCPRFVAHSTLENAKN-TYIKDDTIFL---KVAVD-LTDLE-------------- P_troglodytes_ENSPTRP00000003288 VTLMLLDQSGK------KN-IMETFKPD--PNSSS---FKRP------------DGE--MNI-ASGCPRFVAHSVLENAKN-AYIKDDTLFL---KVAVD-LTDLE-------------- P_pygmaeus_ENSPPYP00000000253 VTLMLLDQSGK------KN-IMETFKPD--PNSSS---FKRP------------DGE--MNI-ASGCPRFVAHSVLENAKN-AYLKDDTLFL---KVAVD-LTDLE-------------- M_mulatta_ENSMMUP00000038268 VTLMLLDQSGK------KN-IMETFKPD--PNSSS---FKRP------------DGE--MNI-ASGCPRFVAHSVLENAKN-AYIKDDTLFL---KVAVD-LTDLE-------------- H_sapiens_ENSP00000336825 VTLMLLDQSGK------KN-IMETFKPD--PNSSS---FKRP------------DGE--MNI-ASGCPRFVAHSVLENAKN-AYIKDDTLFL---KVAVD-LTDLE-------------- T_guttata_ENSTGUP00000003276 VTLMLLDQSGK------KNHIVDVFRAD--PNSSS---FKRP------------DGE--MNI-ASGCPRFVPHTVLESTKN-TYIRDDTLFL---KVVVD-LTDLE-------------- B_taurus_ENSBTAP00000015940 VTLMLLDQSGK------KNHIMETFKAD--PNSSS---FKRP------------DGE--MNI-ASGCPRFVAHSTLENAKN-TYIKDDTLFL---KVAVD-LTDLE-------------- D_rerio_ENSDARP00000014326 ITLTLLDQSGT------RNHMSHTFIPD--VNSDS---FHRP------------TSD--ANV-ATGFTRFISHCDLENPRNAVFVRDETLFI---KVKV--------------------- C_intestinalis_ENSCINP00000003143 VTLMLLDQGMD------RRHLSDTFRPD--PTSSS---FKKP------------TSD--MNI-ASGCPLFVAHNVIEDS---SYVKEDTIFL---RIHVD-TSDLE-------------- G_gallus_ENSGALP00000016021 VTLMLLDQTGK------KNHIVEVFRAD--PNSSS---FKRP------------DGE--MNI-ASGCPRFVPHTVLENTKN-TYVRDDTLFL---KVVVD-LTDLE-------------- A_carolinensis_ENSACAP00000016112 VTLMLLDQSGK------KNHIVETFKAD--PNSSS---FKRP------------EGE--MNV-ASGCPRFVPHTLLENAKS-TYIKDDTIFL---KVVVD-LTDLE-------------- M_domestica_ENSMODP00000003305 VTMMLLDQSGK------KNHITEIFKAD--PNSSS---FKRP------------DGE--MNI-ASGCPRFVAHSTLESTKN-TYIKEDTLFM---KVVVD-LSDLE-------------- C_intestinalis_ENSCINP00000001022 VTLMLLDQGMD------RRHLSDTFRPD--PTSSS---FKKP------------TSD--MNI-ASGCPLFVAHNVIEGS---SYVKEDTIFL---RIHVD-TSDLE-------------- C_intestinalis_ENSCINP00000027890 VTLMLLDQGMD------RRHLSDTFRPD--PTSSS---FKKP------------TSD--MNI-ASGCPLFVAHNVIEDS---SYVKEDTIFL---RIHVD-TSDLE-------------- M_mulatta_ENSMMUP00000015419 VTLMLMDQGSS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--MNI-ASGCPVFVAQTVLENG---TYIK---------------------------------- G_gallus_ENSGALP00000002401 VTFMLLDQNNR-------EHIIDAFRPD--LASAS---FQRP------------VND--MNV-ASGCPTFLPLTKLQSPKH-AYVKEDTLFL---KCIID-LTAV--------------- O_anatinus_ENSOANP00000013484 VTMMLLDQSGK------KNHIVEIFKAD--PNSSS---FKRP------------EGE--MNI-ASGCPCFVDHSKLENVKN-TFIKEDTLFM---KVVVD-LTDLE-------------- O_cuniculus_ENSOCUP00000007884 VTLMLLDQSGK------RNHIMETFKAD--PNSSS---FKRP------------DGE--MNI-ASGCPRFVAHSTLENAKN-TYIKEDTLFL---KVAVD-LTDLE-------------- G_gorilla_ENSGGOP00000004192 VTLMLMDQGSS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--MNI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- C_familiaris_ENSCAFP00000017853 VTLMLLDQSGK------KNHIMETFKAD--PSSSS---FKRP------------DGE--MNI-ASGCPRFVAHSTLENAKN-TYIKDDTVFL---KVAVD-LTDLE-------------- T_rubripes_ENSTRUP00000047803 VTLMLLDQNNR-------EHIIDAFRPD--VTSSS---FQRP------------ISE--MNI-ASGCPLFCPLAKLA-GKS-PYLKDDTIFI---KAIVD-LTGL--------------- P_troglodytes_ENSPTRP00000036949 VTLMLLDQNNR-------EHVIDAFRPD--VTSSS---FQRP------------VND--MNI-ASGCPLFCPVSKME-AKN-SYVRDDAIFI---KAIVD-LTGL--------------- P_pygmaeus_ENSPPYP00000022191 VTLMLLDQNNR-------EHVIDAFRPD--VTSSS---FQRP------------VND--MNI-ASGCPLFCPVSKME-AKN-SYVRDDAIFI---KAIVD-LTGL--------------- T_nigroviridis_ENSTNIP00000011878 VTLMLLDQNNR-------EHIIDAFRPD--VTSSS---FQRP------------ISE--MNI-ASGCPLFCPLAKLA-GKS-PYLKDDTIFI---KAIVD-LTGL--------------- T_nigroviridis_ENSTNIP00000016461 VTLMLLDQSNR-------EHIIDAFRPD--VTSSS---FQRP------------VSE--MNI-ASGCPLFCPLSKLD-GKN-SYIRDDTIFI---KAIVD-LTGL--------------- D_rerio_ENSDARP00000069217 VTLMLLDQNNR-------EHIIDAFRPD--VSSTS---FQRP------------ISE--MNI-ASGCPLFCPLAKLA-GKS-SYLRDDTIFI---KAIVD-LTGL--------------- T_guttata_ENSTGUP00000006737 VTFMLLDQNNR-------EHIIDAFRPD--LTSAS---FQRP------------VND--MNV-ASGCPMFLPLAKLQSPKH-GYVREDTLFL---KCIIE-------------------- O_cuniculus_ENSOCUP00000003184 VTLMLMDQGSS------RRHLGDAFKPD--PNSSS---FRKP------------TGE--MNI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- O_latipes_ENSORLP00000001368 VSLSVLDQSGA------RNHQSFNFRPD--PTNTC---FHQP------------AAESASNV-AVGFPCFISLDALEAPGNAVYVKDDTLFV---KVKVD-TTGLE-------------- H_sapiens_ENSP00000247668 VTLMLLDQNNR-------EHVIDAFRPD--VTSSS---FQRP------------VND--MNI-ASGCPLFCPVSKME-AKN-SYVRDDAIFI---KAIVD-LTGL--------------- T_nigroviridis_ENSTNIP00000013509 VTLMLLDQNNR-------EHIIDAFRPD--VSSSS---FQRP------------VSD--MNI-ASGCPLFCPLSKLD-CKN-SYIRDDTIFI---KVIVD-LSGL--------------- M_musculus_ENSMUSP00000109872 VTLMLLDHNNR-------EHVIDAFRPD--VTSSS---FQRP------------VSD--MNI-ASGCPLFCPVSKME-AKN-SYVRDDAIFI---KAIVD-LTGL--------------- M_domestica_ENSMODP00000021625 VTLMLLDQNNR-------EHVIDAFRPD--VTSSS---FQRP------------VSD--MNI-ASGCPLFCPVSKME-SKN-SYVRDDAIFI---KAIVD-LTGL--------------- G_aculeatus_ENSGACP00000006974 VTLMLLDQNSR-------EHIIDAFRPD--VSSSS---FQRP------------VSD--MNI-ASGCPLFCPLPKLD-SKN-SYIRDDTIFI---KAIVD-LTGL--------------- O_latipes_ENSORLP00000008989 RTIWAASKPNR------EEHIIDAFRPD--ITSTS---FQRP------------VSE--MNI-ASGCPLFCPLAKLA-GKS-PYLRDDTIFI---KAIVD-LSGL--------------- G_gallus_ENSGALP00000014649 VTLMLLDQNNR-------EHIIDAFRPD--VTSSS---FQRP------------VTE--MNI-ASGCPLFCPVSVME-AKN-SYVRDDAIFI---KAIVD-LSGL--------------- O_latipes_ENSORLP00000020860 VTLMLLDQNNR-------EHIIDAFRPD--ISSSS---FQRP------------VSD--MNI-ASGCPLFCPLSKLD-SKN-SYIRDETIFI---KAIVD-LSGL--------------- E_caballus_ENSECAP00000011150 VTLMLLDQNNR-------EHVIDAFRPD--VTSSS---FQRP------------VSD--MNI-ASGCPLFCPVSKME-AKN-SYVRDDAIFI---KAIVD-LTGL--------------- T_rubripes_ENSTRUP00000011363 VTLMLLDQNNR-------EHIIDAFRPD--ISSSS---FQRP------------VSD--MNI-ASGCPLFCPLPKLD-CKN-SYIRDDTIFI---KVIVD-LTGL--------------- B_taurus_ENSBTAP00000013869 VTLMLLDQNNR-------EHVIDAFRPD--VTSSS---FQRP------------VGD--MNI-ASGCPLFCPVSKME-AKN-SYVRDDAIFI---KAIVD-LTGL--------------- M_mulatta_ENSMMUP00000015132 VTLMLLDQNNR-------EHVIDAFRPD--VTSSS---FQRP------------VND--MNI-ASGCPLFCPVSKME-AKN-SYVRDDAIFI---KAIVD-LTGL--------------- O_anatinus_ENSOANP00000001757 VTFMLLDQNNR-------EHVIDAFRPD--LNSAS---FQKP------------QGE--MNV-ASGCPMFFPLNKLQSPKH-AYVKDDTLFL---KCIIE-TNS---------------- X_tropicalis_ENSXETP00000008559 VTLMLLDQNNR-------EHVIDAFRPD--VSSSS---FQRP------------ISE--MNI-ASGCPLFCQVSKLE-GKN-SYVRDDTIFV---KVIVD-LTGL--------------- C_familiaris_ENSCAFP00000028895 VTLMLLDQNNR-------EHVIDAFRPD--VTSSS---FQRP------------VSD--MNI-ASGCPLFCPVSKME-AKN-SYVRDDAIFI---KAIVD-LTGL--------------- O_latipes_ENSORLP00000003220 VTLMLLDQSNR-------EHIIDAFRPD--VTSSS---FQRP------------VSE--MNI-ASGCPLFCPLSKLD-AKN-SYIRDDTIFI---KAIVD-LTGL--------------- D_rerio_ENSDARP00000043465 VTLMLLDQNNR-------EHIIDAFRPD--ISSSS---FQRP------------VSD--MNI-ASGCPLFCPLSKLD-SKN-SYIRDDTIFI---KAIVD-LTGL--------------- G_aculeatus_ENSGACP00000022084 VTLMLLDQNNR-------EHIIDAFRPD--VTSTS---FQRP------------ISE--MNI-ASGCPLFCPLAKLA-GKS-PYLRDDTIFI---KAIVD-LTGL--------------- T_rubripes_ENSTRUP00000015632 VTLMLLDQSNR-------EHIIDAFRPD--VTSSS---FQRP------------VSE--MNI-ASGCPLFCPLSKLD-GKN-SYIRDDTIFI---KAIVD-LTGL--------------- C_elegans_F45G2.6 IKISLLDQNPRPEDRVNITYVIDPRKLK--ANEKF---LARP------------RGE--RNA-AFGSQSFCSLAILQ-----NYVKDDKIYV---QIDVDRCETLPVQLKSRDAKERKQM D_rerio_ENSDARP00000091948 VTFFLLDQNQR-------EHVIDAFRPD--LSSMS---FHQP------------VSD--MNV-ASGCPLFFPLKKLRSPKH-AYCKDDTIYI---KCVVD-TSS---------------- A_carolinensis_ENSACAP00000005007 IRLSVLDQSEGSP----RQNHEEVMDTK--PELLA---FQRP------------KTR--RNPKGFGYVTFMQLQTLRQR---TYIKEDTVLV---RCEVLTRLDVM-------------- E_caballus_ENSECAP00000009372 VTFMLIDQNNR-------EHAIDAFRPD--LNSAS---FQRP------------QSE--TNV-ASGCPLFFPLSRLQSPKH-AYVKDDTMFL---KCIVE-TSA---------------- G_aculeatus_ENSGACP00000020860 VTLMLLDQSNR-------EHIIDAFRPD--VTSSS---FQRP------------LER----------P--CSLC------------------------------F--------------- D_rerio_ENSDARP00000036715 IRLAVLDQ---VE----GQHHIEVMETK--PDLQA---FQRP------------TVM--RNPKGFGYVTFLHLQALRQR---GFVKEDVLLV---RCEVTPRFD-A-------------- T_guttata_ENSTGUP00000002510 VTLMLLDQNNR-------EHIIDAFRPD--VTSSS---FQRP------------VTE--MNI-ASGCPLFCPVSVME-AKN-SYVRDDAIFI---KAIVD-LTGL--------------- M_domestica_ENSMODP00000024498 VTFMLLDQNNR-------EHVTDSFHPD--LTSGS---FQKP------------QGE--SNI-ASGRPMFFPLNKLQSSKH-AYVKDDTLFL---KCVIE-TNS---------------- T_guttata_ENSTGUP00000010462 IRLSILDQSEGPE----RQNHEEVMEAK--PELLA---FQRP------------TIH--RNPKGFGYVTFMHLETLKQR---TFIKDDTLLV---RCEVLTRLDLS-------------- O_anatinus_ENSOANP00000018657 IRLTILDQSEAPV----RQNHEEIMDTK--PELLA---FQRP------------TIH--RNPKGFGYVTFMHLQALRQR---AFIKDDTLLV---RCEVSTRFDMS-------------- X_tropicalis_ENSXETP00000031605 VTLMLLDQSGK------KNHITDVFRAD--PNSSS---FKRP------------DSE--MNI-ASGCPRFASHAQLENPKNGCYIK---------------------------------- H_sapiens_ENSP00000316840 IRLTILDQSEAPV----RQNHEEIMDAK--PELLA---FQRP------------TIP--RNPKGFGYVTFMHLEALRQR---TFIKDDTLLV---RCEVSTRFDMG-------------- P_pygmaeus_ENSPPYP00000003845 IRLTILDQSEAPV----RQNHEEIMDAK--PELLA---FQRP------------TIP--RNPKGFGYVTFMHLEALRQR---TFIKDDTLLV---RCEVSTRFDMG-------------- P_troglodytes_ENSPTRP00000006096 IRLTILDQSEAPV----RQNHEEIMDAK--PELLA---FQRP------------TIP--RNPKGFGYVTFMHLEALRQR---TFIKDDTLLV---RCEVSTRFDMG-------------- T_nigroviridis_ENSTNIP00000012472 IRLAILDQ--GPE----GQHHIEVMETK--PDLQA---FQRP------------TII--RNPKGFGYVTFLHLHHLKER---AYVKDDALLI---RCEVTPRFD-N-------------- M_mulatta_ENSMMUP00000021907 IRLTILDQSEAPV----RQNHEEIMDAK--PDLLA---FQRP------------TIP--RNPKGFGYVTFMHLEALRQR---TFIKDDTLLV---RCEVSTRFDMG-------------- B_taurus_ENSBTAP00000021630 IRLTILDQSEAAV----RQNHEEIMDAK--PELLA---FQRP------------TIP--RNPKGFGYVTFMHLEALRQR---TFIKDDTLLV---RCEVSTRFDMG-------------- C_familiaris_ENSCAFP00000010159 IRLAILDQSEAPV----RQNHEEIMDAK--PELLA---FQRP------------TIP--RNPKGFGYVTFMHLEALRQR---TFIKDDTLLV---RCEVSTRFDMG-------------- M_domestica_ENSMODP00000024756 IRLTILDQSEAPV----RQNHEEIMDAK--PELLA---FQRP------------TIP--RNPKGFGYVTFMHLQALKQR---TFIKDDTLLV---RCEVLTRLDMN-------------- R_norvegicus_ENSRNOP00000006148 IRLTILDQSEAVI----RQNHEEVMDAK--PELLA---FQRP------------TIP--RNPKGFGYVTFMHLEALRQG---TFIKDDTLLV---RCEVSTRFDMG-------------- G_aculeatus_ENSGACP00000022648 IRLAILDQ--GPE----AQHHVEVMETK--PDLQA---FQKP------------LIQ--RNPKGFGYVTFLHLHQLTQR---AFVKDDTLLI---RCEVTPRFD-N-------------- T_rubripes_ENSTRUP00000041697 IRLAILDQ--GPE----GQHHVEVMETK--PDLQA---FQKP------------TII--RNPKGFGYVTFLHLQQLNQR---AYVKDDILLI---RCEVTPRFD-N-------------- M_musculus_ENSMUSP00000004949 IRLTILDQSEALI----RQNHEEVMDAK--PELLA---FQRP------------TIP--RNPKGFGYVTFMHLEALRQG---TFIKDDTLLV---RCEVSTRFDMG-------------- G_gallus_ENSGALP00000012873 IRLSILDQSEGPE----RQNHEEVMEAK--PELLA---FQRP------------TIH--RNPKGFGYVTFMHLQTLKQR---TFVKDDTLLV---RCEVLTRLDLN-------------- A_carolinensis_ENSACAP00000006987 V----------------------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000016445 IRLSILDQSEGVA----MQDQEEVMDTK--PELLA---FQRP------------TVA--RNPKGFGYVTFMHLQALKQR---QYVKNDTLLV---RCSVTTHLDLI-------------- E_caballus_ENSECAP00000018618 IRLTILDQSEAPI----RQNHEEIMDAK--PELLA---FQRP------------TIP--RNPKGFGYVTFMHLEALRQR---TFIKDDTLLV---RCEVSTRFDMG-------------- O_cuniculus_ENSOCUP00000010330 IRLTILDQSEAPI----RQNHEEIMDAK--PELLA---FQRP------------TIP--RNPKGFGYVTFMHLEALRQR---TFIKDDTLLV---RCEVSTRFDMG-------------- R_norvegicus_ENSRNOP00000058607 VTLMLLDHNNR-------EHVIDAFRPD--VTSSS---FQRP------------VSD--MNI-ASGCPLFCPVSKIE-AKN-SYVRDDAIFI---KAIVD-LTGL--------------- M_mulatta_ENSMMUP00000021905 ICLTILDQSQAPV----RQNHEEIMDAK--PELLA---FQQP------------TYP---NPKGFGYVTFIHLEALRQR---TFIKYDTLLV---RCEVSTCFDMG-------------- O_latipes_ENSORLP00000001290 IRLAILDQ--GPE----GQHHMEVMETK--PDLQA---FQKP------------INQ--RNPKGFGYVTFMHRSLLSQR---AYVKDDTLLI---RCEV--------------------- C_elegans_Y110A7A.2 VTFSILSDDKK-------ELLTKTIYVNEMPEIQE--FLERP------------EGL--RNG-TFGFQNFLPLAKVT-----EFAADGDIFI---QIKVLLSKEKQ-------------- A_gambiae_AGAP003004-PA IKITLLNVRSP------ELSQHDTIMSK--PEILA---FHRP------------NQD--ISPRGFGFLEFAKIKDILA----KFADNNTVVI---KIQMNIV------------------ 970 980 990 =========+=========+========== D_melanogaster_FBpp0111838 -----AV----------------------- A_aegypti_AAEL006649-PA -----AV----------------------- A_gambiae_AGAP010017-PA -----AV----------------------- X_tropicalis_ENSXETP00000056667 -----A------------------------ M_musculus_ENSMUSP00000017530 -----S------------------------ R_norvegicus_ENSRNOP00000018468 -----S------------------------ P_troglodytes_ENSPTRP00000015252 -----S------------------------ P_pygmaeus_ENSPPYP00000009119 -----S------------------------ H_sapiens_ENSP00000262395 -----S------------------------ T_rubripes_ENSTRUP00000012878 -----A------------------------ B_taurus_ENSBTAP00000050075 -----S------------------------ B_taurus_ENSBTAP00000016271 -----S------------------------ E_caballus_ENSECAP00000009502 -----S------------------------ M_mulatta_ENSMMUP00000028200 -----S------------------------ G_aculeatus_ENSGACP00000014759 -----T------------------------ O_latipes_ENSORLP00000005579 -----G------------------------ M_domestica_ENSMODP00000024090 -----S------------------------ D_rerio_ENSDARP00000013849 -----A------------------------ D_rerio_ENSDARP00000056877 -----N------------------------ O_cuniculus_ENSOCUP00000000748 ------------------------------ T_nigroviridis_ENSTNIP00000019321 -----A------------------------ G_gorilla_ENSGGOP00000016344 -----S------------------------ C_intestinalis_ENSCINP00000008928 ------------------------------ C_familiaris_ENSCAFP00000027741 -----S------------------------ O_anatinus_ENSOANP00000019424 -----A------------------------ C_intestinalis_ENSCINP00000003738 ------------------------------ M_mulatta_ENSMMUP00000022296 -----S------------------------ T_nigroviridis_ENSTNIP00000005138 -----EP----------------------- T_rubripes_ENSTRUP00000013348 -----EP----------------------- G_aculeatus_ENSGACP00000005703 -----DP----------------------- B_taurus_ENSBTAP00000017918 -----DP----------------------- R_norvegicus_ENSRNOP00000010906 -----DP----------------------- C_familiaris_ENSCAFP00000026713 -----DP----------------------- X_tropicalis_ENSXETP00000027864 -----DP----------------------- D_rerio_ENSDARP00000038596 -----DP----------------------- E_caballus_ENSECAP00000011833 -----DP----------------------- M_domestica_ENSMODP00000016701 -----DP----------------------- M_musculus_ENSMUSP00000021706 -----DP----------------------- O_anatinus_ENSOANP00000023053 -----DP----------------------- T_guttata_ENSTGUP00000013203 -----DP----------------------- G_gallus_ENSGALP00000036699 -----DP----------------------- A_carolinensis_ENSACAP00000000193 -----DP----------------------- M_musculus_ENSMUSP00000082710 -----DL----------------------- P_pygmaeus_ENSPPYP00000007003 -----DP----------------------- P_troglodytes_ENSPTRP00000011503 -----DP----------------------- H_sapiens_ENSP00000376500 -----DP----------------------- E_caballus_ENSECAP00000005414 -----DL----------------------- P_troglodytes_ENSPTRP00000003288 -----DL----------------------- P_pygmaeus_ENSPPYP00000000253 -----DL----------------------- M_mulatta_ENSMMUP00000038268 -----DL----------------------- H_sapiens_ENSP00000336825 -----DL----------------------- T_guttata_ENSTGUP00000003276 -----EL----------------------- B_taurus_ENSBTAP00000015940 -----DL----------------------- D_rerio_ENSDARP00000014326 ------------------------------ C_intestinalis_ENSCINP00000003143 -----NF----------------------- G_gallus_ENSGALP00000016021 -----EL----------------------- A_carolinensis_ENSACAP00000016112 -----EL----------------------- M_domestica_ENSMODP00000003305 -----DL----------------------- C_intestinalis_ENSCINP00000001022 -----NF----------------------- C_intestinalis_ENSCINP00000027890 -----NF----------------------- M_mulatta_ENSMMUP00000015419 ------------------------------ G_gallus_ENSGALP00000002401 ------------------------------ O_anatinus_ENSOANP00000013484 -----EL----------------------- O_cuniculus_ENSOCUP00000007884 -----DL----------------------- G_gorilla_ENSGGOP00000004192 -----DP----------------------- C_familiaris_ENSCAFP00000017853 -----DL----------------------- T_rubripes_ENSTRUP00000047803 ------------------------------ P_troglodytes_ENSPTRP00000036949 ------------------------------ P_pygmaeus_ENSPPYP00000022191 ------------------------------ T_nigroviridis_ENSTNIP00000011878 ------------------------------ T_nigroviridis_ENSTNIP00000016461 ------------------------------ D_rerio_ENSDARP00000069217 ------------------------------ T_guttata_ENSTGUP00000006737 ------------------------------ O_cuniculus_ENSOCUP00000003184 -----DP----------------------- O_latipes_ENSORLP00000001368 ------------------------------ H_sapiens_ENSP00000247668 ------------------------------ T_nigroviridis_ENSTNIP00000013509 ------------------------------ M_musculus_ENSMUSP00000109872 ------------------------------ M_domestica_ENSMODP00000021625 ------------------------------ G_aculeatus_ENSGACP00000006974 ------------------------------ O_latipes_ENSORLP00000008989 ------------------------------ G_gallus_ENSGALP00000014649 ------------------------------ O_latipes_ENSORLP00000020860 ------------------------------ E_caballus_ENSECAP00000011150 ------------------------------ T_rubripes_ENSTRUP00000011363 ------------------------------ B_taurus_ENSBTAP00000013869 ------------------------------ M_mulatta_ENSMMUP00000015132 ------------------------------ O_anatinus_ENSOANP00000001757 ------------------------------ X_tropicalis_ENSXETP00000008559 ------------------------------ C_familiaris_ENSCAFP00000028895 ------------------------------ O_latipes_ENSORLP00000003220 ------------------------------ D_rerio_ENSDARP00000043465 ------------------------------ G_aculeatus_ENSGACP00000022084 ------------------------------ T_rubripes_ENSTRUP00000015632 ------------------------------ C_elegans_F45G2.6 LDAMRAKTPDVRLHQVRPVTSQSSSAELRV D_rerio_ENSDARP00000091948 ------------------------------ A_carolinensis_ENSACAP00000005007 -----SPRREG--FQPRSTDGTV------- E_caballus_ENSECAP00000009372 ------------------------------ G_aculeatus_ENSGACP00000020860 ------------------------------ D_rerio_ENSDARP00000036715 -----SLRREG--VQPRGPEPSI------- T_guttata_ENSTGUP00000002510 ------------------------------ M_domestica_ENSMODP00000024498 ------------------------------ T_guttata_ENSTGUP00000010462 -----SVRREG--FQPRSTDGAM------- O_anatinus_ENSOANP00000018657 -----SPRREG--FQPRSTDPGV------- X_tropicalis_ENSXETP00000031605 ------------------------------ H_sapiens_ENSP00000316840 -----SLRREG--FQPRSTDAGV------- P_pygmaeus_ENSPPYP00000003845 -----SLRREG--FQPRSTDAGV------- P_troglodytes_ENSPTRP00000006096 -----SLRREG--FQPRSTDAGV------- T_nigroviridis_ENSTNIP00000012472 -----MLHRDGVTVQPRGSEASI------- M_mulatta_ENSMMUP00000021907 -----SLRREG--FQPRSTDSGV------- B_taurus_ENSBTAP00000021630 -----SLRREG--FQPRSTDSGI------- C_familiaris_ENSCAFP00000010159 -----SPRREG--FQPRSTDSGI------- M_domestica_ENSMODP00000024756 -----SLRREG--FQPRSTDAGV------- R_norvegicus_ENSRNOP00000006148 -----GLRKEG--FQPRSTDAGV------- G_aculeatus_ENSGACP00000022648 -----VLHRDGPTVQPRGPEASVSRD---- T_rubripes_ENSTRUP00000041697 -----MFHRDGITVQPRGPEASM------- M_musculus_ENSMUSP00000004949 -----GLRKEG--FQPRSTDAGV------- G_gallus_ENSGALP00000012873 -----SLRREG--FQARSTDGAA------- A_carolinensis_ENSACAP00000006987 ------------------------------ X_tropicalis_ENSXETP00000016445 -----SPRREG--FQPRSGDGAL------- E_caballus_ENSECAP00000018618 -----SLRREG--FQPRSTDTGV------- O_cuniculus_ENSOCUP00000010330 -----SLRREG--FQPRSTDAGV------- R_norvegicus_ENSRNOP00000058607 ------------------------------ M_mulatta_ENSMMUP00000021905 -----SLRREG--FQPQSTDAGI------- O_latipes_ENSORLP00000001290 ------------------------------ C_elegans_Y110A7A.2 -----KTQAKEVDSSECQSEMVGSSKAKSE A_gambiae_AGAP003004-PA ------------------------------