10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000051548 ------------------------------------------------MAQNDSQEFAELWEK----NLISIQPPG-------------------------------------------- G_aculeatus_ENSGACP00000025614 ----------------------------------MMEGTGFEGLALGQDLPDSQDSFAELWGNVVSPPLLNLPLAHHN------------------------------------------ X_tropicalis_ENSXETP00000053761 ---------------------------------------MEPSSETGMEPPLSQETFEDLWSLLPDP-----------------L----------------------------------- M_mulatta_ENSMMUP00000035274 --------------------------------------MEEPQSDPSIEPPLSQETFSDLWKLLPENNVLSPLPS---QAVDDLM----------------------------------- P_pygmaeus_ENSPPYP00000008923 --------------------------------------MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPS---QAVDDLL----------------------------------- H_sapiens_ENSP00000269305 --------------------------------------MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPS---QAMDDLM----------------------------------- P_troglodytes_ENSPTRP00000014836 --------------------------------------MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPS---QAMDDLM----------------------------------- G_gorilla_ENSGGOP00000009561 --------------------------------------MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPS---QAMDDLM----------------------------------- B_taurus_ENSBTAP00000001420 --------------------------------------MEESQAELNVEPPLSQETFSDLWNLLPENNLLSSELS---APVDDL------------------------------------ O_cuniculus_ENSOCUP00000000989 --------------------------------------MEESQSDLSLEPPLSQETFSDLWKLLPENNLLTTSLN---PPVDDL------------------------------------ C_familiaris_ENSCAFP00000024579 ------------------------------------AAMQEPQSELNIDPPLSQETFSELWNLLPENNVLSSELC---PAVDEL------------------------------------ M_musculus_ENSMUSP00000104298 -----------------------------------MTAMEESQSDISLELPLSQETFSGLWKLLPPEDILPS-----PHCMDDL------------------------------------ R_norvegicus_ENSRNOP00000047840 --------------------------------------MEDSQSDMSIELPLSQETFSCLWKLLPPDDILPTTATGSPNSMEDL------------------------------------ T_rubripes_ENSTRUP00000030645 ------------------------------------------MEDEGFSLPLSQDTFQDLWENVDVC----------------------------------------------------- G_aculeatus_ENSGACP00000008676 ----------------------------------------MSQS----TVSEEGGTFEHLWSSLEPDSTYYELPPGSQGAERPVP--------------SAGTLGIHRSAAEASMDVYQ- O_latipes_ENSORLP00000019616 ------------------LRRLRDPTSRLSWRDSSFLTAMAQNQSAQ-SDFSSQDVFNQLFDMLDQSAIHSVQPIELNFTDSPTD-------------------GSTGNTIQISMDCITM T_nigroviridis_ENSTNIP00000016776 ------------------VRSLRDSTSRLSWRDSSFLTAMSHNQSSQTSDSFSQDVFNQLFDMLDQSAIHSVQPIELNFTDSLRD-------------------GSAGNTIQISMDCITM T_rubripes_ENSTRUP00000008025 -NFDARRVADMMVAVLPLVCRLRDPASRLSWRDSSFLTTMSHNQSSQTSDSFSQDVFNQLFDMLDQSAIHSVQPIELNFTDSPRD-------------------GSAGNTIQISMDCITM T_nigroviridis_ENSTNIP00000013035 ------------------------------------------MEEETFSLPLSQDTFQDLWENVAAPSISTIQTTVSGNEC--------------------------------------- T_rubripes_ENSTRUP00000038165 ----------------------------------------MSQS----TVTEEGGTFEHLWSSLEPDSTYYELPPGSQQGERPVP--------------STSTPGCHCSAAESSMDVYH- D_rerio_ENSDARP00000074096 ----------------------------------------MSQS----STADEGPTFEHLWSTLEPDSTYFELPQAGHSGDRASS-------------------SLPGNRAEVCMDVYHM X_tropicalis_ENSXETP00000010981 --------------------------------------LKMSQS----SGADEGTTFEHLWSTLEPDSTYFELPQSSHSNNTEAS-----------------------NRTDVNMDVYQ- O_anatinus_ENSOANP00000021753 --LKYSEQRCWMLKFPLIHCRFVETPAHFSWKESYYHSTMS--QSSQTSEFLSPEVFQHIWDFLEQ-PICSVQPIDLNFLDEPSE-------------------NGTTNKIEISMDCIRM C_familiaris_ENSCAFP00000028819 ----------------------------------------MSQS----TANDEGATFEHLWSSLEPDSTYFDLPQPN-QGNSEVV-----------------------GGAEAGMDVFH- C_familiaris_ENSCAFP00000020585 LNIQYCKYGNYNSSFIFILLRFVETPAHFSWKESYYRSTMS--QSTQTNEFLSPEVFQHIWDFLEQ-PICSVQPIDLNFADEPSE-------------------NGARNKIEISMDCIRM O_latipes_ENSORLP00000005521 ----------------------------------------------------------------EPDSTYFELPPNSRPGEHPVA--------------STSISGSHCNSAEVSMDVYH- B_taurus_ENSBTAP00000007643 --------------------------------------------------------------TLQPDCVS---PPPS------------------------------------------- M_domestica_ENSMODP00000018831 MNVDPSPYPTLPCCPEPFIQRFVDTPAHFSWKESYYRSTMS--QSSQTSEFLSPGVFQHIWDFLDQ-PICSVQPIDLNFMDEPTA-------------------NGTTNKIEISMNCIRM R_norvegicus_ENSRNOP00000033463 MNFETSRCATLQYCPDPYIQRFIETPSHFSWKESYYRSAMS--QSTQTSEFLSPEVFQHIWDFLEQ-PICSVQPIDLNFVDEPSE-------------------NGATNKIEISMDCIRM M_musculus_ENSMUSP00000110965 MNFETSRCATLQYCPDPYIQRFIETPAHFSWKESYYRSAMS--QSTQTSEFLSPEVFQHIWDFLEQ-PICSVQPIELNFVDEPSE-------------------NGATNKIEISMDCIRM O_cuniculus_ENSOCUP00000014157 MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSAMS--QNSQPSEFLSPEVFQHIWDFLEQ-PICSVQPIDLNFVDEPSE-------------------NGATNKIEISMDCIRM M_musculus_ENSMUSP00000101269 --------------------------------------MSGSVGEMAQTSSSSSSTFEHLWSSLEPDSTYFDLPQPS-QGTSEAS-----------------------GSEESNMDVFH- G_aculeatus_ENSGACP00000018012 --------------------------------------------------------------------------------------------------------------------MLYL P_pygmaeus_ENSPPYP00000016106 MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMS--QSTQTNEFLSPEVFQHIWDFLEQ-PICSVQPIDLNFVDEPSE-------------------GGATNKIEISMDCIRM M_mulatta_ENSMMUP00000021634 MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMS--QSTQTNEFLSPEVFQHIWDFLEQ-PICSVQPIDLNFVDEPSE-------------------DGATNKIEISMDCIRM H_sapiens_ENSP00000264731 MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMS--QSTQTNEFLSPEVFQHIWDFLEQ-PICSVQPIDLNFVDEPSE-------------------DGATNKIEISMDCIRM P_troglodytes_ENSPTRP00000027067 MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMS--QSTQTNEFLSPEVFQHIWDFLEQ-PICSVQPIDLNFVDEPSE-------------------DGATNKIEISMDCIRM R_norvegicus_ENSRNOP00000052265 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000016315 ---------------------------------------MS--QSTQTSEFLSPEVFQHIWDFLEQ-PICSVQPIDLNFVDEPSE-------------------NGATNKIEISMDCIRM H_sapiens_ENSP00000367545 --------------------------------------MAQSTA----TSPDGGTTFEHLWSSLEPDSTYFDLPQSS-RGNNEVV-----------------------GGTDSSMDVFH- G_gallus_ENSGALP00000011836 --------------------RFVETPSHFSWKESYYRSAMS--QSSQPREFLSPEVIQHIWDFLEQ-PICSVQPIDLNFIDDPSE-------------------NGPTNKIEISMDCVRL T_guttata_ENSTGUP00000002829 --------------------------------------VKMSQS----SPADEGPTFEHLWSTLEPDSTYFDLPPANPSGSNEVS-----------------------DRTEVTMDVFQ- D_rerio_ENSDARP00000065136 --------------------------------------------------------------------------------------------------------------------MLYL T_guttata_ENSTGUP00000009686 MNFEAAPFTTLPYYPDPCIQRFVETPSPFSWKESYYRSAMS--QSSQPREFLSPEVIQHIWDFLEQ-PICSVQPIDLNFIDGPSE-------------------DGSTNKIEISMDCVRV T_nigroviridis_ENSTNIP00000014938 -----------------------------------------VQS----TVTEEGGTFEHLWSSLEPDSTYYELPPGSQQGERPLA--------------STSTPGCHCSAAESSMDVYH- G_gallus_ENSGALP00000001485 --------------------------------------VKMSQS----SPADESTTFEHLWSTLAPDSTYFDLSPSSHTGSNEVS-----------------------NRTEVTMDVFQ- M_mulatta_ENSMMUP00000021768 --------------------------------------MAQSTT----TSPDGGTTFEHLWSSLEPDSTYFDLPQSS-RGNNEVV-----------------------GGTDSSMDVFH- A_carolinensis_ENSACAP00000001746 --------------------------------------VKMSRS----SPADEGTTFEHLWSTLEPDSTYFDLPQSGPRTGSETP-----------------------NRTEVTMDVFQ- O_latipes_ENSORLP00000008029 ----------------------------------------WESMDPVPDLPESQGSFQELWETVYPPLETLSLPTVNEPTGS-------------------------------------- E_caballus_ENSECAP00000006210 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000001313 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000020544 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000005012 MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMS--QSTQTNEFLSPEVFQHIWDFLEQ-PICSVQPIDLNFVDEPSE-------------------DGATNKIEISMDCIRM G_gorilla_ENSGGOP00000015180 --------------------------------------MAQSTA----TSPDGGTTFEHLWSSLEPDSTYFDLPQSS-RGNNEVV-----------------------GGTDSSMDVFH- C_intestinalis_ENSCINP00000003956 -------------------------------------------MDRPPEGSFDPDCFSDIWNNQLSQQSEITSSQQIYTFNENTDGLTNSLTIDLLTEFQQFEQGPTSDANAGENQAGNT M_domestica_ENSMODP00000008216 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000004447 ---------------------------------------MAVADTSELNFPDSQESFSDFWMNTLSENNELPSWQTD--------------------------LNQEYDQCKETVDVLQL A_carolinensis_ENSACAP00000000376 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000002277 --------------------------------------MAQSTA----TSPDGGTTFEHLWSSLEPDSTYFDLPQSS-RGNNEVV-----------------------GGTDSSMDVFH- O_anatinus_ENSOANP00000019815 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000000118 --------------------------------------MAQSTA----TSPDGGTTFEHLWSSLEPDSTYFDLPQSS-RGNNEVV-----------------------GGTDSSMDVFH- M_domestica_ENSMODP00000009014 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007594-PA ----------------------------------MSLLKRPPHETERTNNNLRNRNREEIEHHQKKGGTQHSCFVTVRKTLEMVDSQDTNQTYGQPTQHPVDECDAAQLVQIPTNEFLMD A_aegypti_AAEL007595-PA ----------------------------------------------------MVDSQDLKIESYNEEAEVASDEEMFPLTGNSVSGSAFPMGIDFVTSNGTFVIQQQQLQQQPSNYELKD A_gambiae_AGAP002352-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004319-PA ------------------------------------------------------------------------------------------MSYSPAPDDDAIIAEEDMFATGEGCSQISF 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000051548 ---------GGSCWDIINDEEY-----------LPGSFDPNFFENVLEEQP-----------------------------------------QPSTLPPTSTVPETSDY-PGDHGFRLRF G_aculeatus_ENSGACP00000025614 ---------VWQDGNMEAL--------------LPEGFDEKLFEFPPEVST-----------------------------------------ADGVTPPASTVPVTSDH-PGEFGFQLRF X_tropicalis_ENSXETP00000053761 ---------QTGTGQMENFAEF-----------SEYPLAPDMTVLQEGLMG-----------------------------------------NTVPTVTSSAVPSTEDY-AGSYGLKLEF M_mulatta_ENSMMUP00000035274 ---------LSPDDLAQWLTEDPGPDEAPRMSEAAPPMAPTPAAPTPAAPA-----------------------------------------PAPSWPLSSSVPSQKTY-HGSYGFRLGF P_pygmaeus_ENSPPYP00000008923 ---------LSPDDIAQWFIEDPGPDEAPRMSEAASPVGPAPAAPIPAAPA-----------------------------------------PAPSWPLSSSVPSQKTY-QGSYGFRLGF H_sapiens_ENSP00000269305 ---------LSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPA-----------------------------------------PAPSWPLSSSVPSQKTY-QGSYGFRLGF P_troglodytes_ENSPTRP00000014836 ---------LSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPA-----------------------------------------PAPSWPLSSSVPSQKTY-QGSYGFRLGF G_gorilla_ENSGGOP00000009561 ---------LSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPA-----------------------------------------PAPSWPLSSSVPSQKTY-QGSYGFRLGF B_taurus_ENSBTAP00000001420 ---------LPYTDVATWLDEC--PNEAPQM-----PEPSAPAAPPPATPA-----------------------------------------PATSWPLSSFVPSQKTY-PGNYGFRLGF O_cuniculus_ENSOCUP00000000989 ---------LSAEDVANWLNED--PEEGLRVPAAPAPEAPAPAAPALAAPA-----------------------------------------PATSWPLSSSVPSQKTY-HGNYGFRLGF C_familiaris_ENSCAFP00000024579 ---------LLPESVVNWLDED--SDDAPRM----------PATSAPTAPG-----------------------------------------PAPSWPLSSSVPSPKTY-PGTYGFRLGF M_musculus_ENSMUSP00000104298 ---------LLPQDVEEFFEG---PSEALRVSGAPAAQDPVTETPGPVAPA-----------------------------------------PATPWPLSSFVPSQKTY-QGNYGFHLGF R_norvegicus_ENSRNOP00000047840 ---------FLPQDVAELLEG---PEEALQVS-APAAQEPGTEAPAPVAPA-----------------------------------------SATPWPLSSSVPSQKTY-QGNYGFHLGF T_rubripes_ENSTRUP00000030645 ---------MHPDSPVSQLMNY-----------PELPFNEELFNLPSEMAS-----------------------------------------KDSANLSTPTVPVTTDY-PGEYGFELRF G_aculeatus_ENSGACP00000008676 --MRDMNANVMSQYNLLS--SSM-ESLGS-RATSASPYSSENASSSAVPTPSPY-----------SQPNS----------------------TFEGLSPAPAIPSNTDY-PGLHTFQVSF O_latipes_ENSORLP00000019616 H-EPDETVSCWSQYTNLGLLNNM-ENIQS-SSTSTSPYNNDHAQNN-VTAPSPY-----------AQPSS----------------------TFDALSPSPAIPSNTDY-AGPHSFDVSF T_nigroviridis_ENSTNIP00000016776 H-EPEET--FTSQYTNLGLLNSMDQNIQNGGSTSTSPYNNDHAQNN-VTAPSPY-----------AQPSS----------------------TFDALSPSPAIPSNTDY-AGPHTFDVSF T_rubripes_ENSTRUP00000008025 H-EPEDT--FTSQYTNLGLLNSMDQNIQNGGSTSTSPYNNDHAQNN-VTAPSPY-----------AQPSS----------------------TFDALSPSPAIPSNTDY-AGPHTFDVSF T_nigroviridis_ENSTNIP00000013035 ---------WQDGSLTMAL--------------MDMPYDEDLFNLPSELPN-----------------------------------------KDGANSSCPTVPVTTDH-PGEYDFKLRF T_rubripes_ENSTRUP00000038165 --LRDMNDNVMSQYNLLS--SSM-ESLGS-RATSASPYSSENASSSAVPTPSPY-----------SQPNS----------------------TFEGLSPAPAIPSNTDY-PGLHAFQVSF D_rerio_ENSDARP00000074096 RDMRDMNDNVMSQYSLLS--SSMDQGLGN-RAASTSPYSSETTSN--VPTPSPY-----------SQPNS----------------------TFEAMSPAPAIPSNTDY-PGPHNFEVTF X_tropicalis_ENSXETP00000010981 --MRTMNESIMSQFNLLN--NTMDQSIGS-RAASTSPYNPDHTSN--VPTHSPY-----------SQPSS----------------------TFDAMSPAPVIPSNTDY-PGTHNFEVTF O_anatinus_ENSOANP00000021753 Q-DADVSDPMWPQYTNLGLLNSMDQQIQN-GSSSTSPYNTDHAQNS-VTAPSPY-----------AQPSS----------------------TFDALSPSPAIPSNTDY-PGPHSFDVSF C_familiaris_ENSCAFP00000028819 --LQGMTTPVMSQFNLLS--STMDQ-MSS-RAASASPYTPEHAAS--VPTHSPY-----------AQPSS----------------------TFDTMSPAPAIPSNTDY-PGPHHFDVTF C_familiaris_ENSCAFP00000020585 Q-DSDLSDPMWPQYTNLGLLNSMDQQIQN-GSSSTSPYNTDHAQNS-VTAPSPY-----------AQPSS----------------------TFDALSPSPAIPSNTDY-PGPHSFDVSF O_latipes_ENSORLP00000005521 --MRDTNDNVMSQYNLLS--SSM-ESLGS-RATSASPYSSENASSSAVPTPSPY-----------SQPNS----------------------TFEGLSPAPAIPSNTDY-PGPHDFQVSF B_taurus_ENSBTAP00000007643 ------SPSRQSQFNLLS--STMDQ-MSS-RAASASPYTPEHAAS--VPTHSPY-----------AQPSS----------------------TFDTMSPAPVIPSNTDY-PGPHHFEVTF M_domestica_ENSMODP00000018831 Q-DSDLSDPMWPQYTNLGLLNSMDQQIPN-GSSSTSPYNTDHAQNS-VTAPSPY-----------AQPSS----------------------TFDALSPSPAIPSNTDY-PGPHSFDVSF R_norvegicus_ENSRNOP00000033463 Q-DSDLSDPMWPQYTNLGLLNGMDQQIQN-GSSSTSPYNTDHAQNS-VTAPSPY-----------AQPSS----------------------TFDALSPSPAIPSNTDY-PGPHSFDVSF M_musculus_ENSMUSP00000110965 Q-DSDLSDPMWPQYTNLGLLNSMDQQIQN-GSSSTSPYNTDHAQNS-VTAPSPY-----------AQPSS----------------------TFDALSPSPAIPSNTDY-PGPHSFDVSF O_cuniculus_ENSOCUP00000014157 Q-DSDLGDPMWPQYTNLGLLNSMDQQIQN-GSSSTSPYNTDHAQNS-VTAPSPY-----------AQPSS----------------------TFDALSPSPAIPSNTDY-PGPHSFDVSF M_musculus_ENSMUSP00000101269 --LQG-----MAQFNLLS--SAMDQ-MGS-RAAPASPYTPEHAAS--APTHSPY-----------AQPSS----------------------TFDTMSPAPVIPSNTDY-PGPHHFEVTF G_aculeatus_ENSGACP00000018012 ETGPSTTSYSESQYTNLGLLNSMDQSIQNGGSTSTSPYNNDHAQNS-VTAPSPY-----------AQPSS----------------------TFDALSPSPAIPSNTDY-AGTHAFDVSF P_pygmaeus_ENSPPYP00000016106 Q-DSDLSDPMWPQYTNLGLLNSMDQQIQN-GSSSTSPYNTDHAQNS-VTAPSPY-----------AQPSS----------------------TFDALSPSPAIPSNTDY-PGPHSFDVSF M_mulatta_ENSMMUP00000021634 Q-DSDLSDPMWPQYTNLGLLNSMDQQIQN-GSSSTSPYNTDHAQNS-VTAPSPY-----------AQPSS----------------------TFDALSPSPAIPSNTDY-PGPHSFDVSF H_sapiens_ENSP00000264731 Q-DSDLSDPMWPQYTNLGLLNSMDQQIQN-GSSSTSPYNTDHAQNS-VTAPSPY-----------AQPSS----------------------TFDALSPSPAIPSNTDY-PGPHSFDVSF P_troglodytes_ENSPTRP00000027067 Q-DSDLSDPMWPQYTNLGLLNSMDQQIQN-GSSSTSPYNTDHAQNS-VTAPSPY-----------AQPSS----------------------TFDALSPSPAIPSNTDY-PGPHSFDVSF R_norvegicus_ENSRNOP00000052265 -----------AQFNLLS--SAMDQ-MGS-RAAPASPYTPEHAAS--APTHSPY-----------AQPSS----------------------TFDTMSPAPVIPSNTDY-PGPHHFEVTF E_caballus_ENSECAP00000016315 Q-DSDLSDPMWPQYTNLGLLNSMDQQIQN-GSSSTSPYNTDHAQNS-VTAPSPY-----------AQPSS----------------------TFDALSPSPAIPSNTDY-PGPHSFDVSF H_sapiens_ENSP00000367545 --LEGMTTSVMAQFNLLS--STMDQ-MSS-RAASASPYTPEHAAS--VPTHSPY-----------AQPSS----------------------TFDTMSPAPVIPSNTDY-PGPHHFEVTF G_gallus_ENSGALP00000011836 Q-DTELSDPMWPQYTNLGLLNSMDQQIQN-GSSSTSPYNTEHAQNS-VTAPSPY-----------AQPSS----------------------TFDALSPSPAIPSNTDY-PGPHSFDVSF T_guttata_ENSTGUP00000002829 --MRGMTDSVMSQFNLLN--NSMDQSIGS-RAASTSPYSSEHTSN--VPTHSPY-----------SQPSS----------------------TFDTMSPAPVIPSNTDY-PGPHHFEVTF D_rerio_ENSDARP00000065136 E-TNAPSSYSEPQYTSLGLLNSMD---QNGGSTSTSPYNNDHAQNN-VTAPSPY-----------AQPSS----------------------TFEALSPSPAIPSNTDY-AGPHTFDVSF T_guttata_ENSTGUP00000009686 Q-DTELNDPMWPQYTNLGLLNSMDQQIQN-GSSSTSPYNTEHAQNS-VTAPSPY-----------AQPSS----------------------TFDALSPSPAIPSNTDY-PGPHSFDVSF T_nigroviridis_ENSTNIP00000014938 --LRDMNDNVMSQYNLLS--SSM-ESLGS-RATSASPYSSENASSSAVPTPSPY-----------SQPNS----------------------TFEGLSPAPTIPSNTDY-PGLHAFQVSF G_gallus_ENSGALP00000001485 --MRGMNDSVMSQFNLLN--NSMDQSIGS-RAASTSPYSSEHTSN--VPTHSPY-----------SQPSS----------------------TFDAMSPAPVIPSNTDY-PGPHHFEVTF M_mulatta_ENSMMUP00000021768 --LEGMTTSVMAQFNLLS--STMDQ-MSS-RAASASPYTPEHAAS--VPTHSPY-----------AQPSS----------------------TFDTMSPAPVIPSNTDY-PGPHHFEVTF A_carolinensis_ENSACAP00000001746 --MRSMNTSVMSQFNLLN--GSMDQSTDS-RAASSSPYNSEHASN--VPTLSPY-----------SQPSS----------------------TFDTMSPAPVIPSNTDY-PGPHHFEVTF O_latipes_ENSORLP00000008029 ---------WVATGDMFLLDQD-----------LSGTFDDKIFDIPIEPVP-----------------------------------------TNEVNPPPTTVPVTTDY-PGSYELELRF E_caballus_ENSECAP00000006210 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000001313 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000020544 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000005012 Q-DSDLSDPMWPQYTNLGLLNSMDQQIQN-GSSSTSPYNTDHAQNS-VTAPSPY-----------AQPSS----------------------TFDALSPSPAIPSNTDY-PGPHSFDVSF G_gorilla_ENSGGOP00000015180 --LEGMTTSVMAQFNLLS--STMDQ-MSS-RAASASPYTPEHAAS--VPTHSPY-----------AQPSS----------------------TFDTMSPAPVIPSNTDY-PGPHHFEVTF C_intestinalis_ENSCINP00000003956 EKHDGNEGSYQCLSNFPTSNPPMRSYSND-MTQQNTINQHHPANMANLVTTSSHPINQHNLVYHSTSPNTGDAPNSTQNSPYAPSPCGGYEYPTSPLSSKPTIPPSTDY-PGEWDFQINF M_domestica_ENSMODP00000008216 ---------LQSQFNLLT--NTMDQNSSS-RAASTSPYNPEHSAS--VPTHSPY-----------SQPSS----------------------TFDTMSPAPVIPSNTDY-PGPHHFEVTF C_intestinalis_ENSCINP00000004447 D-TTKANDIEFPVSEFLTSSQASQQSIGD-LFAQSLP-STQCGGNSQVTTVSKH-----------EYPDSGYVMTLPNNSVLAEL-------QTSSLQTEVSLLPNNEY-PGIYNFEINF A_carolinensis_ENSACAP00000000376 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000002277 --LEGMTTSVMAQFNLLS--STMDQ-MSS-RAASASPYTPEHAAS--VPTHSPY-----------AQPSS----------------------TFDTMSPAPVIPSNTDY-PGPHHFEVTF O_anatinus_ENSOANP00000019815 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000000118 --LEGMTTSVM-QFHLLS--STMDQ-MSS-R-AWASPYTPEHAAS--VPTHSPY-----------AQPSS----------------------TFDTMSPAPVIPSNTDY-PGPHHFEVTF M_domestica_ENSMODP00000009014 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007594-PA LDGD-----ILDYHEVLKLGSS---------------------GSSLMGESGDHYMEQKPIVVVDQQTPL----------------------MVALLDHMDRTPTLDEIENPVYNFNVDL A_aegypti_AAEL007595-PA WDSQTME--LFNSQTFADDASKVLRCGDFATGSQDYELPISLKSLENLAPGESINVEVFNGQVDDTQPT-----------------------TTTNLDHLRQFPSVDPMIVPWINFQVSL A_gambiae_AGAP002352-PA ---------MLD--------------------------------------------------------------------------------GREEPTHYKKIPVLDDFTHPLLQFNVAI A_gambiae_AGAP004319-PA LSSQLLEDHILGLDKTLNDSSA---------------------TLALSQTSPGVDIALPSSLLQDGKGS-----------------------LPSSLNPTGKYPSVDELCPADIHFTV-I 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000051548 PQS--GTAKSVTCTYSPDLNKLFCQLAKTCPVQMVVDVA---PPQGSVVRATAIYKKSEHVAEVVRRCPHHERT---PDGDNLAPAGHLIRVE--GNQRANYREDNITL----RHSVFVP G_aculeatus_ENSGACP00000025614 QKS--GTAKSVTSTYSEILNKLYCQLAKTSLIEVLVTKE---LPTGALLRATAVYKKSDHVAEVVRRCPHHQK------EDAADHSSHLIRVE--GSQRAQYFEDPNTK----RQSVTVP X_tropicalis_ENSXETP00000053761 QQN--GTAKSVTCTYSTDLNKLFCQLAKTCPLLVRVERP---PPLGSILRATAVYKKSEHVAEVVKRCPHHERS--VEPGDDPAPPSHLMRVE--GNSKAYYMEDVGTG----RHSVCVP M_mulatta_ENSMMUP00000035274 LHS--GTAKSVTCTYSPDLNKMFCQLAKTCPVQLWVDST---PPPGSRVRAMAIYKQSQHMTEVVRRCPHHERC--SD-SDGLAPPQHLIRVE--GNLRVEYSDDRNTF----RHSVVVP P_pygmaeus_ENSPPYP00000008923 LHS--GTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDST---PPPGTRVRAMAIYKQSQHMTEVVRRCPHHERC--SD-SDGLAPPQHLIRVE--GNLRVEYLDDRNTF----RHSVVVP H_sapiens_ENSP00000269305 LHS--GTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDST---PPPGTRVRAMAIYKQSQHMTEVVRRCPHHERC--SD-SDGLAPPQHLIRVE--GNLRVEYLDDRNTF----RHSVVVP P_troglodytes_ENSPTRP00000014836 LHS--GTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDST---PPPGTRVRAMAIYKQSQHMTEVVRRCPHHERC--SD-SDGLAPPQHLIRVE--GNLRVEYLDDRNTF----RHSVVVP G_gorilla_ENSGGOP00000009561 LHS--GTAKSVTCTYSPTLNKMFCQLAKTCPVQLWVDST---PPPGTRVRAMAIYKQSQHMTEVVRRCPHHERC--SD-SDGLAPPQHLIRVE--GNLRVEYLDDRNTF----RHSVVVP B_taurus_ENSBTAP00000001420 LQS--GTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVDSP---PPPGTRVRAMAIYKKLEHMTEVVRRCPHHERS--SDYSDGLAPPQHLIRVE--GNLRAEYLDDRNTF----RHSVVVP O_cuniculus_ENSOCUP00000000989 LHS--GTAKSVTCTYSPCLNKLFCQLAKTCPVQLWVDST---PPPGSRVRAMAIYKKSQHMTEVVRSCPHHERC--SD-SDGLAPPQHLIRVE--GNLRAEYLDDRNTF----RHSVVVP C_familiaris_ENSCAFP00000024579 LHS--GTAKSVTWTYSPLLNKLFCQLAKTCPVQLWVSSP---PPPNTCVRAMAIYKKSEFVTEVVRRCPHHERC--SDSSDGLAPPQHLIRVE--GNLRAKYLDDRNTF----RHSVVVP M_musculus_ENSMUSP00000104298 LQS--GTAKSVMCTYSPPLNKLFCQLAKTCPVQLWVSAT---PPAGSRVRAMAIYKKSQHMTEVVRRCPHHERC--SD-GDGLAPPQHLIRVE--GNLYPEYLEDRQTF----RHSVVVP R_norvegicus_ENSRNOP00000047840 LQS--GTAKSVMCTYSISLNKLFCQLAKTCPVQLWVTST---PPPGTRVRAMAIYKKSQHMTEVVRRCPHHERC--SD-GDGLAPPQHLIRVE--GNPYAEYLDDRQTF----RHSVVVP T_rubripes_ENSTRUP00000030645 QKS--GTAKSVTSTYSEILNKLYCQLAKTSLVEVLLIKK---PPAGAVLRATAIYKKIEHVADVVRRCPHHQN------EDSAAHRSHLIRME--GSQRAQYFEDPHTK----RQSVTVP G_aculeatus_ENSGACP00000008676 QQS--STAKSATWTYSPLLKKLYCQIAKTCPIQIKLSSS---PPHGSIIRAMPVYKKAEHVTEVVKRCPNHELG-RDFNDGQAAPASHLVRVE--GNNLSQYVDDPVTG----RQSVFLP O_latipes_ENSORLP00000019616 QQS--STAKSATWTYSTDLKKLYCQIAKTCPIQIKVLTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELS-REFNDGQIAPPSHLIRVE--GNNHAQYLEDSITG----RQSVLVP T_nigroviridis_ENSTNIP00000016776 QQS--STAKSATWTYSTDLKKLYCQIAKTCPIQIKVLTT---PPQGAVVRAMPVYKKAEHVTEVVKRCPNHELS-REFNDGQMAPPSHLIRVE--GNNHAQYVEDTITG----RQSVLVP T_rubripes_ENSTRUP00000008025 QQS--STAKSATWTYSTELKKLYCQIAKTCPIQIKVLTT---PPQGAVVRAMPVYKKAEHVTEVVKRCPNHELS-REFNDGQMAPPSHLIRVE--GNNHAQYVEDTITG----RQSVLVP T_nigroviridis_ENSTNIP00000013035 QKS--GTAKSVTSTYSESLNKLYCQLAKTSPLEVLLSRE---PPLGAMLRATAIYKKTEHVAEVVRRCPHHQN------EDSTENRSHLIRME--GSQRAQYFEDPHTK----RQSVTVP T_rubripes_ENSTRUP00000038165 QQS--STAKSATWTYSPLLKKLYCQIAKTCPIQMKLSSS---PPHGSIIRAMPIYKKAEHVTEVVKRCPNHELG-RDFNDGQTAPASHLIRVE--GNNLCQYVDDPVTG----RQSVFVP D_rerio_ENSDARP00000074096 QQS--STAKSATWTYSPLLKKLYCQIAKTCPIQIKLASS---PPNGSVIRAMPIYKKAEHVTEVVKRCPNHELG-RDFNESQTAPASHLIRVE--GNNLCQYVDDPVTG----RQSVLVP X_tropicalis_ENSXETP00000010981 QQS--STAKSATWTYSPLLKKLYCQIAKTCPIQIKLSNP---PPPGSVIRAMPVFKKAEHVTEVVKRCPNHELG-RDFNDGQAAPASHLIRVE--GNNLSQYVDDPVTG----RQSVMVP O_anatinus_ENSOANP00000021753 QQS--STAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELS-REFNEGQIAPPSHLIRVE--GNSHAQYVEDPITG----RQSVLVP C_familiaris_ENSCAFP00000028819 QQS--STAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTP---PPPGTVIRAMPVYKKAEHVTEVVKRCPNHELG-RDFNEGQSAPASHLIRVE--GNNLSQYVDDPVTG----RQSVMVP C_familiaris_ENSCAFP00000020585 QQS--STAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELS-REFNEGQIAPPSHLIRVE--GNSHAQYVEDPITG----RQSVLVP O_latipes_ENSORLP00000005521 QQS--STAKSATWTYSPLLKKLYCQIAKTCPIQIKLVSS---PPHGSIIRAMPVYKKAEHVTEVVKRCPNHELG-RDFNDGQTAPANHLIRVE--GNNLCQYVDDPVTG----RQSAYVP B_taurus_ENSBTAP00000007643 QQS--STAKSATWTYSPLLKKLYCQIAKTCPIQIKVSAP---PPPGTAIRAMPVYKKAEHVTEVVKRCPNHELG-RDFNEGQSAPASHLIRVE--GNNLSQYVDDPVTG----RQSVMVP M_domestica_ENSMODP00000018831 QQS--STAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELS-REFNEGQIAPPSHLIRVE--GNSHAQYVEDPITG----RQSVLVP R_norvegicus_ENSRNOP00000033463 QQS--STAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELS-REFNEGQIAPPSHLIRVE--GNSHAQYVEDPITG----RQSVLVP M_musculus_ENSMUSP00000110965 QQS--STAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELS-REFNEGQIAPPSHLIRVE--GNSHAQYVEDPITG----RQSVLVP O_cuniculus_ENSOCUP00000014157 QQS--STAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELS-REFNEGQIAPPSHLIRVE--GNSHAQYVEDPITG----RQSVLVP M_musculus_ENSMUSP00000101269 QQS--STAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTP---PPPGTAIRAMPVYKKAEHVTDIVKRCPNHELG-RDFNEGQSAPASHLIRVE--GNNLAQYVDDPVTG----RQSVVVP G_aculeatus_ENSGACP00000018012 QQS--STAKSATWTYSTDLKKLYCQIAKTCPIQIKVLTN---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELS-REFNDGQIAPPSHLIRVE--GNNHAQYVEDSITG----RQSVLVP P_pygmaeus_ENSPPYP00000016106 QQS--STAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELS-REFNEGQIAPPSHLIRVE--GNSHAQYVEDPITG----RQSVLVP M_mulatta_ENSMMUP00000021634 QQS--STAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELS-REFNEGQIAPPSHLIRVE--GNSHAQYVEDPITG----RQSVLVP H_sapiens_ENSP00000264731 QQS--STAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELS-REFNEGQIAPPSHLIRVE--GNSHAQYVEDPITG----RQSVLVP P_troglodytes_ENSPTRP00000027067 QQS--STAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELS-REFNEGQIAPPSHLIRVE--GNSHAQYVEDPITG----RQSVLVP R_norvegicus_ENSRNOP00000052265 QQS--STAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTP---PPPGTAIRAMPVYKKAEHVTDIVKRCPNHELG-RDFNEGQSAPASHLIRVE--GNNLSQYVDDPVTG----RQSVVVP E_caballus_ENSECAP00000016315 QQS--STAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELS-REFNEGQIAPPSHLIRVE--GNSHAQYVEDPITG----RQSVLVP H_sapiens_ENSP00000367545 QQS--STAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTP---PPPGTAIRAMPVYKKAEHVTDVVKRCPNHELG-RDFNEGQSAPASHLIRVE--GNNLSQYVDDPVTG----RQSVVVP G_gallus_ENSGALP00000011836 QQS--STAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELS-REFNEGQIAPPSHLIRVE--GNSHAQYVEDPITG----RQSVLVP T_guttata_ENSTGUP00000002829 QQS--STAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTS---PPPGTIIRAMPVYKKAEHVTEVVKRCPNHELG-RDFNDGQSAPASHLIRVE--GNNLSQYVDDPVTG----RQSVMVP D_rerio_ENSDARP00000065136 QQS--STAKSATWTYSTELKKLYCQIAKTCPIQIKVLTN---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELS-REFNDGQIAPPSHLIRVE--GNSHAQYVEDSITG----RQSVLVP T_guttata_ENSTGUP00000009686 QQS--STAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELS-REFNEGQIAPPSHLIRVE--GNSHAQYVEDPITG----RQSVLVP T_nigroviridis_ENSTNIP00000014938 QQS--STAKSATWTYSPLLKKLYCQIAKTCPIQIKLSSS---PPHGSIIRAMPIYKKAEHVTEVVKRCPNHELG-RDFNDGQTAPASHLIRVE--GNNLCQYVDDPITG----RQ-VFVP G_gallus_ENSGALP00000001485 QQS--STAKSATWTYSPLLKKLYCQIAKTCPIQIKVSSP---PPPGTIIRAMPVYKKAEHVTEVVKRCPNHELG-RDFNDGQSAPASHLIRVE--GNNLSQYVDDPVTG----RQSVMVP M_mulatta_ENSMMUP00000021768 QQS--STAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTP---PPPGTAIRAMPVYKKAEHVTDIVKRCPNHELG-RDFNEGQSAPASHLIRVE--GNNLSQYVDDPVTG----RQSVVVP A_carolinensis_ENSACAP00000001746 QQS--STAKSATWTYSPLLKKLYCQIAKTCPIQIKVSGP---PPPGTIIRAMPVYKKAEHVTEVVKRCPNHELG-RDFNDGLSAPASHLIRVE--GNNLSQYVDDPVTG----RQSVMVP O_latipes_ENSORLP00000008029 QKS--GTAKSVTSTYSETLNKLYCQLAKTSPIEVRVSKE---PPKGAILRATAVYKKTEHVADVVRRCPHHQN------EDSVEHRSHLIRVE--GSQLAQYFEDPYTK----RQSVTVP E_caballus_ENSECAP00000006210 --------------YSPTLNKLFCQLAKTCPVQLLVSSP---PPPGTRVRAMAIYKKSEFMTEVVRRCPHHERC--SDSSDGLAPPQHLIRVE--GNLRAEYLDDRNTF----RHSVVVP E_caballus_ENSECAP00000001313 --------------YSPLLKKLYCQIAKTCPIQIKVSTP---PPPGTAIRAMPVYKKAEHVTEVVKRCPNHELG-RDLNEGQSAPASHLIRVE--GNNLSQYVDDPVTG----RQSVMVP B_taurus_ENSBTAP00000020544 --------------YSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELS-REFNEGQIAPPSHLIRVE--GNSHAQYVEDPITG----RQSVLVP G_gorilla_ENSGGOP00000005012 QQS--STAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELS-REFNEXXXXXXXXXXXXX--XXXXXXXXXXXXXX----XXXXXXX G_gorilla_ENSGGOP00000015180 QQS--STAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTP---PPPGTAIRAMPVYKKAEHVTDVVKRCPNHELG-RDFNEGQSAPASHLIRVE--GNNLSQYVDDPVTG----RQSVVVP C_intestinalis_ENSCINP00000003956 GEATESAPKSAQYTYSPIINKLFVKMNVTCPIKFKCARP---PPNGCVVRVMPVFKRPEHVTDIVTRCPNHKIPDQ---AQHIPHSQHLIRAEMPGENPAIY-NVAMDG----RENVAVM M_domestica_ENSMODP00000008216 QQS--STAKSATWTVSCLLLAL---------LRLSPPSL---PPPPSL---PPVLSGASLDEEVRPFCLHYRL----FGRNQGKVEGENMRTC--GLQWSRKEDDLVLA----KQ----P C_intestinalis_ENSCINP00000004447 GEKTESAPKSAPFTYSYSLQKLFVKMNENCPIKFRCSPQ---PPSGCVIRAIPVFEKPNNVTEIVTRCFNHRNECRTESSDSNTPNSHLIRVE--SKSNNIQYCLTHEG----RECVVVP A_carolinensis_ENSACAP00000000376 --------------YSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELS-REFNEGEPDHPGSL-------SSHPLRVHWALLGDSKFNQDNHFP P_pygmaeus_ENSPPYP00000002277 QQS--STAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTP---PPPGTAIRAMPVYKKAEHVTDVVKRCPNHELG-RDFNEGQSAPASHLIRVE--GNNLSQYVDDPVTG----RQSVVVP O_anatinus_ENSOANP00000019815 --------------------------------------------------------------------------------GQSAPASHLIRVE--GNNLSQYVDDPVTG----RQSVMVP P_troglodytes_ENSPTRP00000000118 QQS--STAKSATWTYSPLVKTLYCQIAKTCPILIK------------AIRAMPVY-IAEHVTDVHKRCPNHELG-RDFNE-----ASHLFRVK--ANNLSQYVDDPV-G----RQSVVVP M_domestica_ENSMODP00000009014 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007594-PA NGE---TSGKSSWMFSSRLNKVFVKMGQACTFNISYQAL---THQELFVRAMMVCSAPEDMHYPVYRCENHRGSDNVNPKLPNEVKAHVMRCF---NPSARYVGTENGVAFKDRLAVIIP A_aegypti_AAEL007595-PA PSE---TSDKTSWMFSRKLQKLFVKMGNTCTFNVSQLPS---PDRDTTVRAMVVCSTPEDRHLPVSRCDNHRCSDNQD--IPDSIKTHIVRCK---NEQVTYTGTKDGKTFEERLAVLVP A_gambiae_AGAP002352-PA SGK---PCSASAWCYSNALEKLFVKKKTPVTFDVTYMQPS--DYSRLKLRIMLVYSNSQYAYQTISRCQDDIAKDG---AKDFAHKEHVVRCL---NPDASFTGREKGVNFEDRLAVLVD A_gambiae_AGAP004319-PA PSS----TQGSGFIFSEQLQKLFLKTDSICSFDIACQLPTFLPPTGWYVRVMLVSLAPESQHESITRCHKHIAHDT----GPEEIRKHVVRCK---NEQHEYVGADNGPFFEDRYAVRVP 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000051548 YEA----PQLG-AEWTTVLL----NYMCN-SSCM--GGMNRRPILTIITLETQE---GQLLGRRSFEVRVCACPGRDRKTEESNFKKDQE-TKTMA-----------------------K G_aculeatus_ENSGACP00000025614 YEL----PQLG-TEMTTILL----SFMCN-SSCM--GGMNRRPILTILTLETPE---GLVLGRRCFEVRVCACPGRDRKSEEIKSKTQI------------------------------G X_tropicalis_ENSXETP00000053761 YEG----PQVG-TECTTVLY----NYMCN-SSCM--GGMNRRPILTIITLESPE---GLLLGRRCFEVRVCACPGRDRRTEEDNCTKKRG------------------------------ M_mulatta_ENSMMUP00000035274 YEP----PEVG-SDCTTIHY----NYMCN-SSCM--GGMNRRPILTIITLEDSS---GNLLGRNSFEVRVCACPGRDRRTEEENFRKKGE--PCHQ-----------------------L P_pygmaeus_ENSPPYP00000008923 YEP----PEVG-SDCTTIHY----NYMCN-SSCM--GGMNRRPILTIITLEDSS---GNLLGRNSFEVRVCACPGRDRRTEEENFRKKGE--PHHE-----------------------L H_sapiens_ENSP00000269305 YEP----PEVG-SDCTTIHY----NYMCN-SSCM--GGMNRRPILTIITLEDSS---GNLLGRNSFEVRVCACPGRDRRTEEENLRKKGE--PHHE-----------------------L P_troglodytes_ENSPTRP00000014836 YEP----PEVG-SDCTTIHY----NYMCN-SSCM--GGMNRRPILTIITLEDSS---GNLLGRNSFEVRVCACPGRDRRTEEENLRKKGE--PHHE-----------------------L G_gorilla_ENSGGOP00000009561 YEP----PEVG-SDCTTIHY----NYMCN-SSCM--GGMNRRPILTIITLEDSS---GNLLGRNSFEVRVCACPGRDRRTEEENLRKKGE--PHHE-----------------------L B_taurus_ENSBTAP00000001420 YES----PEID-SECTTIHY----NFMCN-SSCM--GGMNRRPILTIITLEDSC---GNLLGRNSFEVRVCACPGRDRRTEEENLRKKGQ--SCPE-----------------------P O_cuniculus_ENSOCUP00000000989 YEP----PEFG-SDCTTIHY----NYMCN-SSCM--GGMNRRPILTIITLEDSS---GNLLGRNSFEVRVCACPGRDRRTEEENFRKKGE--PCPE-----------------------L C_familiaris_ENSCAFP00000024579 YEP----PEVG-SDYTTIHY----NYMCN-SSCM--GGMNRRPILTIITLEDSS---GNVLGRNSFEVRVCACPGRDRRTEEENFHKKGE--PCPE-----------------------P M_musculus_ENSMUSP00000104298 YEP----PEAG-SEYTTIHY----KYMCN-SSCM--GGMNRRPILTIITLEDSS---GNLLGRDSFEVRVCACPGRDRRTEEENFRKKEV--LCPE-----------------------L R_norvegicus_ENSRNOP00000047840 YEP----PEVG-SDYTTIHY----KYMCN-SSCM--GGMNRRPILTIITLEDSS---GNLLGRDSFEVRVCACPGRDRRTEEENFRKKEE--HCPE-----------------------L T_rubripes_ENSTRUP00000030645 YEP----PQLG-SEFTTILL----SFMCN-SSCM--GGMNRRPILTILTLETQE---GVVLGRRCFEVRVCACPGRDRKTEEANSTNMQN-----------------------------G G_aculeatus_ENSGACP00000008676 YEA----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRE---GQVLGRRSFEGRICACPGRDRKADEDHFREQQALHESVA-----------------------K O_latipes_ENSORLP00000019616 YEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADEDSIRKQHVTD--AS-----------------------K T_nigroviridis_ENSTNIP00000016776 YEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADEDSIRKQHVTD--AT-----------------------K T_rubripes_ENSTRUP00000008025 YEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADEDSIRKQHVTD--AT-----------------------K T_nigroviridis_ENSTNIP00000013035 YEP----PQLG-SEFTTILL----SFMCN-SSCM--GGMNRRPILAILTLETQE---GVVLGRRCFEVRVCACPGRDRKTEEANSTKMQT-----------------------------E T_rubripes_ENSTRUP00000038165 YEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRD---GQVLGRRSFEARICACPGRDRKADEDHFREQQALSDSVD-----------------------K D_rerio_ENSDARP00000074096 YES----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRD---GQVLGRRSFEGRICACPGRDRKADEDHFREQQALNESVA-----------------------K X_tropicalis_ENSXETP00000010981 YEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRD---GQVLGRRSFEGRICACPGRDRKADEDHFREQAALNETAA-----------------------K O_anatinus_ENSOANP00000021753 YEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADEDSIRKQQVSD--ST-----------------------K C_familiaris_ENSCAFP00000028819 YEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRD---GQVLGRRSFEGRICACPGRDRKADEDHYREQQALSESAA-----------------------K C_familiaris_ENSCAFP00000020585 YEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADEDSIRKQQVSD--SA-----------------------K O_latipes_ENSORLP00000005521 YET----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRD---GQVLGRRSFEGRICACPGRDRKADEDHFREQQALNESVA-----------------------K B_taurus_ENSBTAP00000007643 YEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRD---GQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESAA-----------------------K M_domestica_ENSMODP00000018831 YEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADEDSIRKQQVSD--SS-----------------------K R_norvegicus_ENSRNOP00000033463 YEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADEDSIRKQQVSD--SA-----------------------K M_musculus_ENSMUSP00000110965 YEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADEDSIRKQQVSD--SA-----------------------K O_cuniculus_ENSOCUP00000014157 YEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADEDSIRKQQVSD--ST-----------------------K M_musculus_ENSMUSP00000101269 YEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILVIITLETRD---GQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESTT-----------------------K G_aculeatus_ENSGACP00000018012 YEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADEDGIRKQHVTD--AT-----------------------K P_pygmaeus_ENSPPYP00000016106 YEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADEDSIRKQQVSD--ST-----------------------K M_mulatta_ENSMMUP00000021634 YEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADEDSIRKQQVSD--ST-----------------------K H_sapiens_ENSP00000264731 YEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADEDSIRKQQVSD--ST-----------------------K P_troglodytes_ENSPTRP00000027067 YEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADEDSIRKQQVSD--ST-----------------------K R_norvegicus_ENSRNOP00000052265 YEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILVIITLETRD---GQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESTT-----------------------K E_caballus_ENSECAP00000016315 YEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADEDSIRKQQVSD--ST-----------------------K H_sapiens_ENSP00000367545 YEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLEMRD---GQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSA-----------------------K G_gallus_ENSGALP00000011836 YEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADEDSIRKQQVSD--ST-----------------------K T_guttata_ENSTGUP00000002829 YEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRD---GQVLGRRSFEGRICACPGRDRKADEDHFREQQALNESTA-----------------------K D_rerio_ENSDARP00000065136 YEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADEDSIRKQHVTD--GT-----------------------K T_guttata_ENSTGUP00000009686 YEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADEDSIRKQQVSD--ST-----------------------K T_nigroviridis_ENSTNIP00000014938 YEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRDNISGQVLGRRSFEARICACPGRDRKADEDHFREQQALSDSVD-----------------------K G_gallus_ENSGALP00000001485 YEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRD---GQVLGRRSFEGRICACPGRDRKADEDHYREQQALNENAA-----------------------K M_mulatta_ENSMMUP00000021768 YEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRD---GQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESST-----------------------K A_carolinensis_ENSACAP00000001746 YEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRD---GQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESAA-----------------------K O_latipes_ENSORLP00000008029 YEP----PQPG-SEMTTILL----SYMCN-SSCM--GGMNRRPILTILTLET-E---GLVLGRRCFEVRICACPGRDRKTEEESRQKTQP------------------------------ E_caballus_ENSECAP00000006210 YEP----PEVG-SDCTTIHY----NFMCN-SSCM--GGMNRRPILTIITLEDSS---GNLLGRNSFEVRVCACPGRDRRTEEENFRKKEE--PCPE-----------------------P E_caballus_ENSECAP00000001313 YEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRD---GQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESAA-----------------------K B_taurus_ENSBTAP00000020544 YEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADEDSIRKQQVSD--ST-----------------------K G_gorilla_ENSGGOP00000005012 XXX----XXVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADEDSIRKQQVSD--ST-----------------------K G_gorilla_ENSGGOP00000015180 YEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXESSA-----------------------K C_intestinalis_ENSCINP00000003956 FER----PQIG-AEYTTVLY----KFMCL-SSCV--GGINRRPLNAVFNLENAE---GQVLGRRVVEVRVCSCPGRDRSQEEKRKRTAES-----------------------------E M_domestica_ENSMODP00000008216 REPTATHPQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRD---GQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESAA-----------------------K C_intestinalis_ENSCINP00000004447 YEP----PHSG-SEYMALLY----RFMCL-SSCRTETGINRRPLLTIFNLESET---GELLGKRVVSTRICACPGRDRTQEEEKKNVT-------------------------------S A_carolinensis_ENSACAP00000000376 FCV----LQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GNLLQLWRSWGHI-ARVGDDR----DVVSIENIQS--NE-----------------------H P_pygmaeus_ENSPPYP00000002277 YEP----PQ--------------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000019815 YEP----PQTD-DNIESLLYFSQIHHICNPSTCL--TGLKKTVLVVYCEQNTVR---GQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESAA-----------------------K P_troglodytes_ENSPTRP00000000118 YEP----PQ--------------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000009014 -----------------------------------------------------R---GQLLGRRSFEVRICACPGRDRRTEEENFHKKGG--PSPQ-----------------------P A_aegypti_AAEL007594-PA LGM----TSQE-QVALNVSL----EFVCQ-NSCR---IINRRTTAIIFTLEDVH---GQILGKKSLHLKVCSCPKRDKMKEEETV---APTKRKSDTQLQAPPGKKIAKVATLSRQIAAQ A_aegypti_AAEL007595-PA MGH---------SAKTGITL----EFVCQ-NSCR---NINRRATALVFTLEDQA---GRILGRQVFQIKICTNIKRDMVNEEKAVMEESSRKRKAAAQSWEH-----------------K A_gambiae_AGAP002352-PA LNNGGTPQHLEKQQTVPVSL----EFLCQ-NSCP---TMERRATTLVFTVENEH---GTLLGRKSISVKICSCPKRDMEKDDSKATGG-------------------------------R A_gambiae_AGAP004319-PA LDD--------EVLCVKIML----QFVCQ-NTCF---RLDQRRTGLVFTLENDQ---GNIWARRVVPVKICINYRRDMQNEQNSAINFLPTSCLTAGRSD-------------------A 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000051548 TTTGTK-----RSLVKE-SSSATL----------RPEGSKKA-KGS-----SSDEEI------FTLQVRGRERYEILKKLNDSLELSDVVPASDAEK-YR--QKFM------TKNKK--E G_aculeatus_ENSGACP00000025614 TKQTTK-----RKNPAP-TPN-----------------TSEKKAKSASSAEEEDKDV------FVLRVRGRERYEWLKKIHDGLELLDRERLSKPTV-SV--KHEA------AAPSGG-- X_tropicalis_ENSXETP00000053761 LKPNGK-----RELSHP-PSS-----------------DPPLPKKRLIGSVPLTAVT------FRLQIKGRSRYEMIKKLNDALELQESLDQQKLSIKCR--KCRD------EIKPK--K M_mulatta_ENSMMUP00000035274 PPGSTK-----RALPNN-TSS-----------------SPQP-KKK-----PLDGEY------FTLQIRGRERFEMFRELNEALELKDAQAGKEPAG-SR--AHSS------HLKSK--K P_pygmaeus_ENSPPYP00000008923 PPGSTK-----RALPNN-TSS-----------------SPQP-KKK-----PLDGEY------FTLQIRGRERFEMFRELNEALELKDAQAGKEPGG-SR--AHSS------HLKSK--K H_sapiens_ENSP00000269305 PPGSTK-----RALPNN-TSS-----------------SPQP-KKK-----PLDGEY------FTLQIRGRERFEMFRELNEALELKDAQAGKEPGG-SR--AHSS------HLKSK--K P_troglodytes_ENSPTRP00000014836 PPGSTK-----RALPNN-TSS-----------------SPQP-KKK-----PLDGEY------FTLQIRGRERFEMFRELNEALELKDAQAGKEPGG-SR--AHSS------HLKSK--K G_gorilla_ENSGGOP00000009561 PPGSTK-----RALPNN-TSS-----------------SPQP-KKK-----PLDGEY------FTLQIRGRERFEMFRELNEALELKDAQAGKEPGG-SR--AHSS------HLKSK--K B_taurus_ENSBTAP00000001420 PPRSTK-----RALPTN-TSS-----------------SPQP-KKK-----PLDGEY------FTLQIRGFKRYEMFRELNDALELKDALDGREPGE-SR--AHSS------HLKSK--K O_cuniculus_ENSOCUP00000000989 PPGSSK-----RALPTT-TTD----------------SSPQT-KKK-----PLDGEY------FILKIRGRERFEMFRELNEALELKDAQAEKEPGG-SR--AHSS------YLKAK--K C_familiaris_ENSCAFP00000024579 PPGSTK-----RALPPS-TSS-----------------SPPQ-KKK-----PLDGEY------FTLQIRGRERYEMFRNLNEALELKDAQSGKEPGG-SR--AHSS------HLKAK--K M_musculus_ENSMUSP00000104298 PPGSAK-----RALPTC-TSA-----------------SPPQ-KKK-----PLDGEY------FTLKIRGRKRFEMFRELNEALELKDAHATEESGD-SR--AHSS------YLKTK--K R_norvegicus_ENSRNOP00000047840 PPGSAK-----RALPTS-TSS-----------------SPQQ-KKK-----PLDGEY------FTLKIRGRERFEMFRELNEALELKDARAAEESGD-SR--AHSS------YPKTK--K T_rubripes_ENSTRUP00000030645 TKETKK-----RKSVPPPAAA-----------------AAAKKSKTASSAEEDDKEL------FTLQIRGRKRYEMLKKINDGLELLENKPKCKAAA-----KPEC------PVPPRG-- G_aculeatus_ENSGACP00000008676 NGTANK-----RNFKQS-PPN--I----------PSPNINMR-KRR-----HGEEEI------YYIPVRGRENFELLMKIKDSLELVELVPQPLVDS-YR-QQTQQ------QLLQR--P O_latipes_ENSORLP00000019616 SSEGTK-----RRYRQV-SHG--I----------QM--STIK-KRR-----STDEEV------FCLPIKGREIYEILVKIKESLELMQFLPQHTIES-YR--QQQQ------NLLQK--Q T_nigroviridis_ENSTNIP00000016776 SSEGTK-----HPFRQV-SHG--I----------QM--STIK-KRR-----STDEEV------FCLPIKGREIYEILVKIKESLELMQFLPQHTIES-YR--QQQQ------SLLQK--Q T_rubripes_ENSTRUP00000008025 SSEGTK-----HPFRQV-SHG--I----------QM--STIK-KRR-----STDEEV------FCLPIKGREIYEILVKIKESLELMQFLPQHTIES-YR--QQQQ------NLLQK--Q T_nigroviridis_ENSTNIP00000013035 TKDAKK-----RKSAPT-SDS-----------------TTVKKSRTASSAEEDDKEV------FTLQIRGRKRYEMIKRINDGLDLLENKTKSKTTY-----KPEG------PVLPSG-- T_rubripes_ENSTRUP00000038165 NGSANK-----RNFKQS-LPT--I----------QNPNLNSR-KRR-----HGEEDL------YYIPVRGRENFELLMKIKDSLELVELVPQPLLDS-YR--QQTQ------QLLQR--P D_rerio_ENSDARP00000074096 NGNANK-----RNFKQT-PTN--I----------TGPSINIK-KRR-----HGEEEM------YYIPVRGRENFDILMKIKDSLELVEFVPQQLVDS-YR--QQQQ------QLLQR--Q X_tropicalis_ENSXETP00000010981 NGNANK-----RTFKQS-PPS--V----------PSMGSNIK-KRR-----HGEDEI------FYIPVRGRENFEILMKIKESLELVELVPQQLVDS-YR--QQQQ------QLLQR--Q O_anatinus_ENSOANP00000021753 NGDGTK-----RPFRQS-THG--I----------QM--TSIK-KRR-----SPDDEL------LYLPVRGRETYEMLLKIKESLELMQYLPQHTIET-YR--QQQQQQHQ--HLLQK--Q C_familiaris_ENSCAFP00000028819 NGAASK-----RAFKQS-PPA--V----------PALGANVK-KRR-----HGDEDV------YYMHVRGRENFEVLMKVKESLELMELVPQQLVDT-YQ-MTRSC------CCLSR--- C_familiaris_ENSCAFP00000020585 NGDGTK-----RPFRQN-THG--I----------QM--TSIK-KRR-----SPDDEL------LYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYYR--YHQQQIHHFTHLLKKSIK O_latipes_ENSORLP00000005521 NGSANK-----RNFKQS-PPN--I----------PNPNMNMR-KRR-----HGEEEI------YYIPVRGRENFELLMRIKDSLELVELVPQPLIDS-YR-HQTQQ------QMLQR--P B_taurus_ENSBTAP00000007643 SGAASK-----RAFKQS-PPT--A----------PALGTNVK-KRR-----HGDDDV------YYIHVRGRENFEILMKVKESLELMELVPQQLVDS-YR--QQQQ------QLLQR--P M_domestica_ENSMODP00000018831 NGDGTK-----RPFRQN-THG--I----------QM--TSIK-KRR-----SPDDEL------LYLPVRGRETYEMLLKIKESLELMQYLPQHTIET-YR--QQQQQQHQ--HLLQK--Q R_norvegicus_ENSRNOP00000033463 NGDGTK-----RPFRQN-THG--I----------QM--TSIK-KRR-----SPDDEL------LYLPVRGRETYEMLLKIKESLELMQYLPQHTIET-YR--QQQQQQHQ--HLLQK--Q M_musculus_ENSMUSP00000110965 NGDGTK-----RPFRQN-THG--I----------QM--TSIK-KRR-----SPDDEL------LYLPVRGRETYEMLLKIKESLELMQYLPQHTIET-YR--QQQQQQHQ--HLLQK--Q O_cuniculus_ENSOCUP00000014157 NGDGTK-----RPFRQN-THG--I----------QM--TSIK-KRR-----SPDDEL------LYLPVRGRETYEMLLKIKESLELMQYLPQHTIET-YR--QQQQQQHQ--HLLQK--X M_musculus_ENSMUSP00000101269 NGAASK-----RAFKQS-PPA--I----------PALGTNVK-KRR-----HGDEDM------FYMHVRGRENFEILMKVKESLELMELVPQPLVDS-YR-QQQQQ------QLLQR--P G_aculeatus_ENSGACP00000018012 GGDG---------FRQV-SHG--I----------PM--STIK-KRR-----STDEEV------FCLPIKGREIYEILVKIKESLELMQFLPQHTIES-YR--QQQQ------NLLQK--Q P_pygmaeus_ENSPPYP00000016106 NGDGTK-----RPFRQN-THG--I----------QM--TSIK-KRR-----SPDDEL------LYLPVRGRETYEMLLKIKESLELMQYLPQHTIET-YR--QQQQQQHQ--HLLQK--Q M_mulatta_ENSMMUP00000021634 NGDGTK-----RPFRQN-THG--I----------QM--TSIK-KRR-----SPDDEL------LYLPVRGRETYEMLLKIKESLELMQYLPQHTIET-YR--QQQQQQHQ--HLLQK--Q H_sapiens_ENSP00000264731 NGDGTK-----RPFRQN-THG--I----------QM--TSIK-KRR-----SPDDEL------LYLPVRGRETYEMLLKIKESLELMQYLPQHTIET-YR--QQQQQQHQ--HLLQK--Q P_troglodytes_ENSPTRP00000027067 NGDGTK-----RPFRQN-THG--I----------QM--TSIK-KRR-----SPDDEL------LYLPVRGRETYEMLLKIKESLELMQYLPQHTIET-YR--QQQQQQHQ--HLLQK--Q R_norvegicus_ENSRNOP00000052265 NGAASK-----RAFKQS-PPA--I----------PALGTNVK-KRR-----HGDEDM------FYMHVRGRENFEILMKVKESLELMELVPQPLVDS-YR-QQQQQ------QLLQR--P E_caballus_ENSECAP00000016315 NGDGTK-----RPFRQN-THG--I----------QM--TSIK-KRR-----SPDDEL------LYLPVRGRETYEMLLKIKESLELMQYLPQHTIET-YR--QQQQQQHQ--HLLQK--Q H_sapiens_ENSP00000367545 NGAASK-----RAFKQS-PPA--V----------PALGAGVK-KRR-----HGDEDT------YYLQVRGRENFEILMKLKESLELMELVPQPLVDS-YR---QQQ------QLLQR--P G_gallus_ENSGALP00000011836 NGDGTK-----RPFRQG-THG--I----------QM--TSIK-KRR-----SPDDEL------LYLPVRGRETYEMLLKIKESLELMQYLPQHTIET-YR--QQQQQQHQ--HLLQK--Q T_guttata_ENSTGUP00000002829 NGNANK-----RTFKQS-PQG--I----------PALGTGIK-KRR-----HGEEEM------YYVPVQGRENFEILMKIKESLELVELVPQQLVDS-YR--QQQQ------QLLQR--Q D_rerio_ENSDARP00000065136 SSEA---------FRQASSHL--S----------QL--NSIK-KRR-----STDEEV------FCLPIKGREIYEILVKIKESLELMQFLPQQTIES-YR--QQQQ------NLLQK--Q T_guttata_ENSTGUP00000009686 NGDGTK-----RPFRQG-THG--I----------QM--TSIK-KRR-----SPDDEL------LYLPVRGRETYEMLLKIKESLELMQFLPQHTIET-YR--QQQQQQHQ--HLLQK--Q T_nigroviridis_ENSTNIP00000014938 NGSANK-----RNFKQS-LPN--I----------QNPNLNTR-KRR-----HGEEDV------YYIPVRGRENFELLMKIKDSLELVELVPQPLLDS-YR--QQTQ------QFLQR--P G_gallus_ENSGALP00000001485 NGNANK-----RTFKQS-PQA--I----------PALGPGVK-KRR-----HGEEEM------YYVPVRGRENFEILMKIKESLELVELVPQQLVDS-YR--QQQQ------QLLQR--Q M_mulatta_ENSMMUP00000021768 NGAAGK-----RAFKQS-PPA--V----------PALGPGVK-KRR-----HGDEDT------YYLQVRGRENFEILMKLKESLELMELVPQPLVDS-YR---QQQ------QLLQR--P A_carolinensis_ENSACAP00000001746 NGNPNK-----RTFKQS-PQG--M----------PALGAGMK-KRR-----HGEEET------YYVPVRGRENFEILMKIKESMELVELVPQQLVDS-YR--QQQQ------QLLQR--Q O_latipes_ENSORLP00000008029 ----KK-----RSMLEV-TPN---------------TSSSKRKKSHSSGEEEDNREV------FHFEVYGRERYEFLKKINDGLELLEKESPTNDSS-AM--KKKC------LTAVIAKK E_caballus_ENSECAP00000006210 PPRSTK-----RVLSSN-TSS-----------------SPPQ-KKK-----PLDGEY------FTLQIRGRERFEMFRELNEALELKDAQTGKEPGG-SK--AHSS------HLKSK--K E_caballus_ENSECAP00000001313 NAAAGK-----RAFKQS-PPA--I----------PALGTNVK-KRR-----HGDEDT------YYMHVRGRENFEILMKVKESLELMELVPQQLVDS-YRQQQQQQ------QLLQR--P B_taurus_ENSBTAP00000020544 NGDGTK-----RPFRQN-THG--I----------QM--TSIK-KRR-----SPDDEL------LYLPVRGRETYEMLLKIKESLELMQYLPQHTIET-YR--QQQQQQHQ--HLLQK--Q G_gorilla_ENSGGOP00000005012 NGDGTK-----RPFRQN-THG--I----------QM--TSIK-KRR-----SPDDEL------LYLPVRGRETYEMLLKIKESLELMQYLPQHTIET-YR--QQQQQQHQ--HLLQK--Q G_gorilla_ENSGGOP00000015180 NGAASK-----RAFKQS-PPA--V----------PALGAGVK-KRR-----HGDEDT------YYLQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XX---XXX------XXLQR--P C_intestinalis_ENSCINP00000003956 VKSGSK-----RTYKCM-QGSMNI------------VQTAPA-KRKCAMNGNDDQEE------FTLKIRGRDKFEMLKKIKEALDLAEVAAHQQVEN-YR--DEDA------RTFKVEPS M_domestica_ENSMODP00000008216 NGNATK-----RTFKQS-PPA--I----------PALVANVK-KRR-----HGDEEI------YYMPVRGRENFEILMKIKESLELVDLVPQQLVDS-YR--QQQQ------QLLQR--P C_intestinalis_ENSCINP00000004447 QNKSRK-----RLCKSA-TNSKSI------------PVVQKN-EENKVDNDDDGDVV------YTLNIRGKRKFEKVKEYKEALDLLDYVQPDVKKA-CC--QRNQ-------------- A_carolinensis_ENSACAP00000000376 NVPLITFFLPVTAFRQS-THG--I----------QM--TSVK-KRR-----TPDDEL------LYLPVRGRETYEMLLKIKESLELMQYLPQHTIET-YR--QQQQQQQQHQHLLQK--Q P_pygmaeus_ENSPPYP00000002277 -------------------------------------------------------------------VRGRENFEILMKLKESLELMELVPQPLVDS-YR---QQQ------QLLQR--P O_anatinus_ENSOANP00000019815 NGNANK-----RTFKQS-PPA--V----------PALGTTVK-KRR-----HGDEEM------YYVPVRGRENFEILMKIKESLELVELVPQQLVDS-YA-AGTTA------PLFPD--R P_troglodytes_ENSPTRP00000000118 --GAAK-----RAFKQS-PPA--V----------PALGAGVK-KRR-----HGDEDT------YYLQ----------------------------------------------------- M_domestica_ENSMODP00000009014 SSESNK-----RALPTT-PGS-----------------TPKA-KKK-----LVEGEY------FTLQIRGRQRYELLREINEALELKEAHSRKEPEG-SR--PHRS------QLKSK--R A_aegypti_AAEL007594-PA QQQLQQ-----RRLTPS-PTSGKLAFIKREIS-AESLNGCNQ-KARSITPSHSQEMVEANGIPVTVLLPSVEMANKVAEYAFQIVAAELVRSHADQD-----DSKKLAAYLTNIRRV--- A_aegypti_AAEL007595-PA RGKKIVRYHSGLPLSHS-QTSAGI---------------QIK-EESGNRRCNIDPVT------FTVTMPNRRMARRMLDIGIGQISTAVVNTSNDA------ERNELMQFVHDIRRI--- A_gambiae_AGAP002352-PA ENNKNK-----RKHAAT-PLLGQIKREPSFTPLGYSLSNLSN-SSNSTIDNDSSAVV------LTLRLPDLACASEVAMYAFKHLSSILISCKDEK------DKNRYAQYLSHCRRV--- A_gambiae_AGAP004319-PA PGTSAV-----RRYKAG-RPGKRLQRGGKLGPGGGSVNRADR-TVPVRAARNIEPCT------VNIEMPSLRMAKRVMDNAIGMVSAQILLEDDTE------TKNRLKVFLDSIRRQ--- 610 620 630 640 650 660 670 680 690 700 710 720 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000051548 NRESSEPKQG-------------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000025614 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000053761 G----------------------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000035274 GQSTSRH----------------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000008923 GQSTSRH----------------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000269305 GQSTSRH----------------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000014836 GQSTSRH----------------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000009561 GQSTSRH----------------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000001420 RPSPSCH----------------------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000000989 GQSTSRH----------------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000024579 GQSTSRH----------------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000104298 GQSTSRH----------------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000047840 GQSTSRH----------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000030645 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008676 SHIASPSPYSP-LSNMNKQNVHGGLNKSPSVNQLVGQQSQQHPTGPA-SIVHM---GSNML------------NS--HHMQGNGDMNGGHSSQ------TIVSASHCSPPPPYNPDPSLV O_latipes_ENSORLP00000019616 TSMPSQPSFGSTSPTPGK------VNKLPSVSQLINPQQRNTLTPSS-MTGGL---TD-MT------------PMMAPHIPMNADMSSLSPTHALQPQLPLVPSSHCTPPPPYPMDSSIA T_nigroviridis_ENSTNIP00000016776 TSVPSQPSYGSCSPTHGK------VNKLPSVSQLMNPQQRNTLTPSS-MTGGL---AD-MS------------PMMGTHVPMNADMSSLSPTHALQPQLPLVPSSHCTPPPPYPMDSSIS T_rubripes_ENSTRUP00000008025 TSVPSQPSYGSCSPTHGK------VNKLPSVSQLMNPQQRNTLTPSS-MSGGL---TD-MS------------PMMGTHVPMNADMSSLSPTHALQQQLPLVPSSHCTPPPPYPMDSSIS T_nigroviridis_ENSTNIP00000013035 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000038165 GHISSPSSYSP-LSNMNKLHNQGGISKPPSSINLMGQQPQQHHTAPS-SLTHM---GSSML------------SS--HHMQANGDMNGSHSNQ------TIVSASHCSPPPPYNPDPSLV D_rerio_ENSDARP00000074096 NHVASPSSYGT-LNNMNKIH--GPISKLPSVNQLVTQQTQQSAGPSA-SLSHM---GANML------------GG--HHMQSNGDVNGAHQSQ------SIVSTSHCTPPPPYNPDPSLV X_tropicalis_ENSXETP00000010981 THLQSTSSYGPVLSPMNKLH--GGINKLPSVNQLVGQPNQHNSNAGP-NMGPM---GPSML------------NS--HPLQTNGEMNGAHSSQ------SMVSGSHCTPPPPYNADPSLV O_anatinus_ENSOANP00000021753 SSMQSQ-SYGGNSPPLNKMN---SMNKLPSVSQLINPQQRNALTPTA-ISDGM---GA-NI------------PMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIV C_familiaris_ENSCAFP00000028819 SHLQPA-SYGPVLSPMNKAH--GGVNKLPSVNQLVGQPPPHGSAAGP-NLGPM---GPGIL------------NNHGHALPASSEMNGSHSAQ------SMVSGSHCTPPPPYHADPSLV C_familiaris_ENSCAFP00000020585 TSMQSQSTYGNSSPPLNKMN---SMNKLPSVSQLINPQQRNALTPTT-IPDGM---GA-NI------------PMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSLV O_latipes_ENSORLP00000005521 SNINSPSSYSP-LSNMNKIHSHGGLSK-PSVNQMMGQQPQQH--ANS-SMSHM---GPNML------------NN--SHLQANGEMNSGHSNH------NIVSASHCSPPPSYNPDPSLV B_taurus_ENSBTAP00000007643 SHLQPP-SYGPVLSPMSKAH--GAVNKLPSVNQLVGQPPPHGSAAGP-NLGPM---GPGIL------------NNHGHTLPANGEMNGGPSSQ------SMVSGSHCTPPPPYHADSSLV M_domestica_ENSMODP00000018831 TSMQSQTSYGTSSPPLSKMN---SINKLPSVSQLINPQQRNALTPTA-IPDGM---GA-NI------------PMMGTHMPMAGDMNGLSPTQALPPTLSMPSTSHCTPPPPYPTDCSIV R_norvegicus_ENSRNOP00000033463 TSMQSQSSYGNSSPPLNKMN---SMNKLPSVSQLINPQQRNALTPTT-MPEGM---GA-NI------------PMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIV M_musculus_ENSMUSP00000110965 TSMQSQSSYGNSSPPLNKMN---SMNKLPSVSQLINPQQRNALTPTT-MPEGM---GA-NI------------PMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIV O_cuniculus_ENSOCUP00000014157 XXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXALTPLAPIPDGM---GA-HI------------PMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIV M_musculus_ENSMUSP00000101269 SHLQPP-SYGPVLSPMNKVH--GGVNKLPSVNQLVGQPPPHSSAAGP-NLGPM---GSGML------------NSHGHSMPANGEMNGGHSSQ------TMVSGSHCTPPPPYHADPSLV G_aculeatus_ENSGACP00000018012 RHSVSF------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000016106 TSIQSQSSYGNSSPPLNKMN---SMNKLPSVSQLINPQQRNALTPTT-IPDGM---GA-NI------------PMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIV M_mulatta_ENSMMUP00000021634 TSIQSQSSYGNSSPPLNKMN---SMNKLPSVSQLINPQQRNALTPTT-IPDGM---GA-NI------------PMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIV H_sapiens_ENSP00000264731 TSIQSPSSYGNSSPPLNKMN---SMNKLPSVSQLINPQQRNALTPTT-IPDGM---GA-NI------------PMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIV P_troglodytes_ENSPTRP00000027067 TSIQSPSSYGNSSPPLNKMN---SMNKLPSVSQLINPQQRNALTPTT-IPDGM---GA-NI------------PMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIV R_norvegicus_ENSRNOP00000052265 SHLQPP-SYGPVLSPMNKVH--GGVNKLPSVNQLVGQPPPHSSAAGP-NLGSM---GSGIL------------NSHSHSMPANGEMNGGHSSQ------TMVSGSHCTPPPPYHADPSLV E_caballus_ENSECAP00000016315 TSMQSQSSYGNSSPPLNKMN---SMNKLPSVSQLINPQQRNALTPTT-IPDGM---GA-NI------------PMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSLV H_sapiens_ENSP00000367545 SHLQPP-SYGPVLSPMNKVH--GGMNKLPSVNQLVGQPPPHSSAATP-NLGPV---GPGML------------NNHGHAVPANGEMSSSHSAQ------SMVSGSHCTPPPPYHADPSLV G_gallus_ENSGALP00000011836 TSIQSQSSYGSNSPPLSKMN---SMNKLPSVSQLINPQQRNALTPTT-IPDGM---GT-NI------------PMMGTHMAMTGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIV T_guttata_ENSTGUP00000002829 SQLQTASSYGPVLSPMNKVHG-GGINKLPSVNQLVGQPAQHGSSSAP-SLGPM---GPGML------------NS--HPMQTNGEMNGGHSSQ------SMVSGSHCTPPPPYNADPSLV D_rerio_ENSDARP00000065136 SSLPPQPAFGSSSPTLGK-------NKLPSVSQLINPQQRNALTPSG-MPGGL---TDSLLQSQPFPLPSVTPPMMGGPVPMNTDLSSLSPNNPLQSQLQMVPSSHCTPPPPYPMDNSIS T_guttata_ENSTGUP00000009686 TSMQSQSSYGSNSPPLSKMN---SMNKLPSVSQLINPQQRNALTPTT-IPDSM---GT-NI------------PMMGTHMAMTGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPSDCSIV T_nigroviridis_ENSTNIP00000014938 GHISSPTSYSP-LSNMNKLHNQGGISK-PSSVNLMGQQPQQHHSAPS-SLAHM---GSNML------------SS--HHMQANGDMNGSHSNQ------TIVSASHCSPPPPYNPDPSLV G_gallus_ENSGALP00000001485 NQLQTPSSYGPVLSPMNKAHG-GGINKLPSVNQLVGQPAQHSSGSAP-SLGPM---GPGML------------NS--HPMQPNGEMNGGHSSQ------SMVSGSHCTPPPPYNPDPSLV M_mulatta_ENSMMUP00000021768 SHLQPP-SYGPVLSPMNKVH--GGMNKLPSVNQLVGQPPPHSSAATP-NLGPV---GAGML------------NNHGHAVPANGEMSSSHSTQ------SMVSGSHCTPPPPYHADPSLV A_carolinensis_ENSACAP00000001746 THLQPPSSYGPVLSPMNKLHA-GGVNKLPSVNQLVGQPQQHGPNTGP-NLGPM---GPGIL------------NS--HPMQSNGDMNGGHSSQ------SMVSGAHCSPPPPYNPDPSLV O_latipes_ENSORLP00000008029 DIFCTQPTS--------------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000006210 GQSTSSH----------------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000001313 SPLQSP-SYGPVLSPMNKAH--GGISKLPSVNQLVGQPPPHSSAAGP-NLGPM---GPGIL------------NNHGHALPANGEMNGSHSSQ------SMVSGSHCTPPPPYHADPSLV B_taurus_ENSBTAP00000020544 TSMQSQSSYGNSSPPLNKMN---SMNKLPSVSQLINPQQRNALTPTT-IPDGM---GA-NI------------PMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSLV G_gorilla_ENSGGOP00000005012 TSIQSPSSYGNSSPPLSKMN---SMNKLPSVSQLINPQQRNALTPTT-IPDGM---GA-NI------------PMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIV G_gorilla_ENSGGOP00000015180 SHLQPP-SYGPVLSPMNKVH--GGMNKLPSVNQLVGQPPPHSSAATP-NLGPV---GPGML------------NNHGHAVPANGEMSSSHSTQ------SMVSGSHCTPPPPYHADPSLV C_intestinalis_ENSCINP00000003956 SIHGKYP----------------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000008216 HWGDQALGMG------QQAQKEGGDTKMP------GNSSPHSPISHL-QLLPFLSTGPGML------------NSHGHPMQSNGEMNGGHTSQ------SMVSGSHCTPPPPYNADPSLV C_intestinalis_ENSCINP00000004447 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000000376 ASLQSPSSYGSNSPPLGKMN---SVNKLPSVSQLMNPQQRNALTPTS-LPDSM---GA-NI------------PMMG-HMAMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIV P_pygmaeus_ENSPPYP00000002277 SHLQPP-SYGPVLSPMNKVH--GGMNKLPSVNQLVGQPPPHSSAATP-NLGPV---GPGML------------NNHGHAVPANGEMSSSHGAQ------SMVSGSHCTPPPPYHADPSLV O_anatinus_ENSOANP00000019815 SHLQSPSSYGPVLSPMNKVH--GVVNKLPSVNQLVGQPTAHSSAAGA-NLGPV---GPGML------------NSHGHPMQPNGEINGGHAPQ------PMVSGSHCTPPPPYNADPSLV P_troglodytes_ENSPTRP00000000118 ---------------------------------------------------------PGML------------NNHGHAVPANGEMGSSHSAQ------SMVSGSHCTPPPPYHADPSLV M_domestica_ENSMODP00000009014 GDSTPCQ----------------------------------------------------------------------------------------------------------------- A_aegypti_AAEL007594-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007595-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP002352-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004319-PA ------------------------------------------------------------------------------------------------------------------------ 730 740 750 760 770 780 790 800 810 820 830 840 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000051548 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000025614 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000053761 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000035274 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000008923 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000269305 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000014836 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000009561 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001420 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000000989 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000024579 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000104298 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000047840 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000030645 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008676 SFLTSLGCQNFIEYFTSQGLQSIYHLQTLSMEDLSALKIPEQFRLAIWRGLQDMKQVAPLQLPASTHHHDYHG--QQLLRSSSNMTASAMAAIGAASGELQRQRVMEAVHFRVRHTITIP O_latipes_ENSORLP00000019616 SFLVRLGCAGCLDYFTAQGLSNIYQIENYNLEDLCRLKIPTEFQNIIWRGIMEHRQA-----------MDFSPP-PHIVRTTSGASTVSV-----GAAEARGERVIDAVRFTLRQTISFP T_nigroviridis_ENSTNIP00000016776 SFLLRLGCAGCLDYFTAQGLTNIYQIENYNMEDLSRLKIPSEFQHIIWKGIMEHRQA-----------MDFSPP-PHIVRSTSGASSVSV-----GAAEARSERVIDAVRFTLRQTISFP T_rubripes_ENSTRUP00000008025 SFLLRLGCAGCLDYFTAQGLTNIYQIENYNMEDLSRLKIPSEFQHIIWKGIMEHRQA-----------MDFSPP-PHIVRTTSGASSVSV-----GATEARGERVIDAVRFTLRQTISFP T_nigroviridis_ENSTNIP00000013035 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000038165 SFLTSLGCQNFIEYFASQGLQSVYHLQTLSMEDLGAMKIPEQSRLAIWRGLQDMKQGSPLQLPPSAHHHDYHG--QQLIRSSSNMTSSAMAAIGGPGGELQRQRVMEAVHFRVRHTITIP D_rerio_ENSDARP00000074096 SFLTSLGCQNCIDYFTSQGLQSVYHLQTLTMEDLGALKIPEQFRLAIWRGLQEMKQG-----------HDYG---QQLIRSSSNMATMAI----GPSGELQRQRVMEAVHFRVRHTITIP X_tropicalis_ENSXETP00000010981 SFLTGLGCPNCIEYFTSQGLQNIYHLQNLTMEDLGALKIPEHYKSMIWRGIQELNKS-----------HEYGA--QQLVRSSSNASTISI----GSSGELQRQRVMEAVHFRVRHTITIP O_anatinus_ENSOANP00000021753 SFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQL-----------HDFSSP-PHLLRTPSGASTVSV-----GSSETRGERVIDAVRFTLRQTISFP C_familiaris_ENSCAFP00000028819 SFLTGLGCPNCIEYFTSQGLQNIYHLQNLTIEDLGALKIPDQYRMTIWRGLQDLKQS-----------HDYGA--QQLIRSSSNASTISI----GSSGELQRQRVMEAVHFRVRHTITIP C_familiaris_ENSCAFP00000020585 SFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQL-----------HDFSSP-PHLLRTPSGASTVSV-----GSSETRGERVIDAVRFTLRQTISFP O_latipes_ENSORLP00000005521 SFLTSLGCQNFIEYFTSQGLQSVYHLQTLSMEDLAALKIPEQSRLVIWRGLQDMKQGVPVQLPPSAHHHDYHG--QQLLRSSGNMAASAMAAIGSSGGELQRQRVMEAVHFRVRHTITIP B_taurus_ENSBTAP00000007643 SFLTGLGCPNCIEYFTSQGLQNIYHLQNLTIEDLGALKIPDQYRMTIWRGLQDLKQS-----------HDYSA--QQLIRSSSNAATIAI----GGSGELQRQRVMEAVHFRVRHTITIP M_domestica_ENSMODP00000018831 SFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQL-----------HDFSSP-PHLLRTPSGSSTVSV-----GSSETRGERVIDAVRFTLRQTISFP R_norvegicus_ENSRNOP00000033463 SFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQL-----------HDFSSP-PHLLRTPSGASTVSV-----GSSETRGERVIDAVRFTLRQTISFP M_musculus_ENSMUSP00000110965 SFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQL-----------HDFSSP-PHLLRTPSGASTVSV-----GSSETRGERVIDAVRFTLRQTISFP O_cuniculus_ENSOCUP00000014157 SFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDXXXXXXXXXXXXXXXXXXXXXXXXX-----------XXXXXX-XXXXXXXXXXXXXXX-----XXXXXXXXXXXXXXXXXXXXXXXXX M_musculus_ENSMUSP00000101269 SFLTGLGCPNCIECFTSQGLQSIYHLQNLTIEDLGALKVPDQYRMTIWRGLQDLKQS-----------HDCG---QQLLRSSSNAATISI----GGSGELQRQRVMEAVHFRVRHTITIP G_aculeatus_ENSGACP00000018012 -------------------------------------------------------------------------------------------------------------------TVLFP P_pygmaeus_ENSPPYP00000016106 SFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQL-----------HEFSSP-SHLLRTPSSASTVSV-----GSSETRGERVIDAVRFTLRQTISFP M_mulatta_ENSMMUP00000021634 SFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQL-----------HEFSSP-SHLLRTPSSASTVSV-----GSSETRGERVIDAVRFTLRQTISFP H_sapiens_ENSP00000264731 SFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQL-----------HEFSSP-SHLLRTPSSASTVSV-----GSSETRGERVIDAVRFTLRQTISFP P_troglodytes_ENSPTRP00000027067 SFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQL-----------HEFSSP-SHLLRTPSSASTVSV-----GSSETRGERVIDAVRFTLRQTISFP R_norvegicus_ENSRNOP00000052265 SFLTGLGCPNCIECFTSQGLQSIYHLQNLTIEDLGALKIPDQYRMTIWRGLQDLKQS-----------HDCG---QQLLRSSSNAATISI----GGSGELQRQRVMEAVHFRVRHTITIP E_caballus_ENSECAP00000016315 SFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQL-----------HDFSSP-PHLLRTPSGASTVSV-----GSSETRGERVIDAVRFTLRQTISFP H_sapiens_ENSP00000367545 SFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMTIWRGLQDLKQG-----------HDYST--AQQLLRSSNAATISI----GGSGELQRQRVMEAVHFRVRHTITIP G_gallus_ENSGALP00000011836 SFLARLGCSSCVDYFTTQGLTTIYQIEHYSMDDLVSLKIPEQFRHAIWKGILDHRQL-----------HDFSSP-PHLLRTPSGASTVSV-----GSSETRGERVIDAVRFTLRQTISFP T_guttata_ENSTGUP00000002829 SFLTGLGCPNCIDYFTSQGLQNIYHLQNLSIEDLAALKIPEQYRMLIWRGLQELKQS-----------HDYGA--QQLIRSSSNASTISI----GSSGELQRQRVMEAVHFRVRHTITIP D_rerio_ENSDARP00000065136 SFLLRLGCSACLDYFTAQGLTNIYQIENYNLEDLSRLKIPTEFQHIIWKGIMEYRQT-----------MEFSPP-PHILRTSSGTSTVSV-----GSTEARGERVIDAVRFTLRQTISFP T_guttata_ENSTGUP00000009686 SFLARLGCSSCVDYFTTQGLTTIYQIEHYSMDDLVSLKIPEQFRHAIWKGILDHRQL-----------HDFSSP-PHLLRTPSGASTVSV-----GSSETRGERVIDAVRFTLRQTISFP T_nigroviridis_ENSTNIP00000014938 SFLTSLGCQNFIEYFASQGLQSVYHLQTLSMEDLGAMKIPEQSRLAIWRALQDLKQDGPLQLPATTHHHDYHG--QQLIRSSSNMTASAMAAIGGPGGELQRQRVMEAVHFRVRHTITIP G_gallus_ENSGALP00000001485 SFLTGLGCPNCIDYFTSQGLQNIYHLQNLSIEDLGALKIPEQYRMIIWRGLQELKQS-----------HDYGA--QQLIRSSSNASTISI----GSSGELQRQRVMEAVHFRVRHTITIP M_mulatta_ENSMMUP00000021768 SFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIELIAGTMI-KQPRACLWPGAADRDEG-----------HTLSQ--LQQLLRSSNAAAISI----GGSGELQRQRVMEAVHFRVRHTITIP A_carolinensis_ENSACAP00000001746 SFLTGLGCSNCIDYFTSQGLQTLYQLQNLTLEDLVLLKIPEQYRMIIWRGLQDLKQG-----------HDYGA--QQLIRSSGNASTISI----GASGELQRQRVMEAVHFRVRHTITIP O_latipes_ENSORLP00000008029 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000006210 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000001313 SFLTGLGCPNCIEYFTSQGLQNIYHLQNLTIEDLGALKIPDQYRMTIWRGLQDLKQG-----------HDYGA--QQLIRSSSNASTISI----GSSGELQRQRVMEAVHFRVRHTITIP B_taurus_ENSBTAP00000020544 SFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQL-----------HDFSSP-PHLLRTPSGASTVSV-----GSSETRGERVIDAVRFTLRQTISFP G_gorilla_ENSGGOP00000005012 SFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDXXXXXXXXXXXXXXXXXXXXXXXXX-----------XXXXXX-XXXXXXXXXXXXXXX-----XXXXXXXXXXXXAVRFTLRQTISFP G_gorilla_ENSGGOP00000015180 SFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMTIWRGLQDLKQG-----------HDYST--AQQLLRSSNSATISI----GGSGELQRQRVMEAVHFRVRHTITIP C_intestinalis_ENSCINP00000003956 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008216 SFLTGLGCPNCIEYFTSQGLQNIYHLQNLTIEDLGALKIPDQYRMTIWRGLQELKQS-----------HDYGA--QQLIRSSSNASTISI----GSSGELQRQRVMEAVHFRVRHTITIP C_intestinalis_ENSCINP00000004447 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000000376 SFLARLGCSSCVDYFTAQGLTTIYQIEHYSMDDLVSLKIPEQFRHAIWKGLMDHRQL-----------HDFSSSTPHLLRTPSGASTVSV-----GSSETRGERVIDAVRFTLRQTISFP P_pygmaeus_ENSPPYP00000002277 SFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMTIWRGLQDLKQG-----------HDYST--AQQLLRSSNAATISI----GGSGELQRQRVMEAVHFRVRHTITIP O_anatinus_ENSOANP00000019815 SFLTGLGCPNCIEYFTTQGLQNIYHLQNLTLEDLGALKIPDQYRMVIWRGLQDLKQS-----------HDYGA--QQLIRSSSNASTISI----GSSGELQRQRVMEAVHFRVRHTITIP P_troglodytes_ENSPTRP00000000118 SFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMTIWRGLQDLKQG-----------HDYST--TQQLLRSSNAATISI----GGSGELQRQRVMEAVHFRVRHTITIP M_domestica_ENSMODP00000009014 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007594-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007595-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP002352-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004319-PA ------------------------------------------------------------------------------------------------------------------------ 850 860 870 880 890 =========+=========+=========+=========+=========+=== D_rerio_ENSDARP00000051548 -------------------------------------KKLMVKDEGRS--DSD G_aculeatus_ENSGACP00000025614 -------------------------------------KRLLRS-------DSE X_tropicalis_ENSXETP00000053761 -------------------------------------KKLLVKDEL-Q--DSE M_mulatta_ENSMMUP00000035274 -------------------------------------KKFMFKTEG-P--DSD P_pygmaeus_ENSPPYP00000008923 -------------------------------------KKLMFKTEG-P--DSD H_sapiens_ENSP00000269305 -------------------------------------KKLMFKTEG-P--DSD P_troglodytes_ENSPTRP00000014836 -------------------------------------KKLMFKTEG-P--DSD G_gorilla_ENSGGOP00000009561 -------------------------------------KKLMFKTEG-P--DSD B_taurus_ENSBTAP00000001420 -------------------------------------KKPMLKREG-P--DSD O_cuniculus_ENSOCUP00000000989 -------------------------------------KKPMFKREG-P--DSD C_familiaris_ENSCAFP00000024579 -------------------------------------KKLMFKREG-P--DSD M_musculus_ENSMUSP00000104298 -------------------------------------KKTMVKKVG-P--DSD R_norvegicus_ENSRNOP00000047840 -------------------------------------KKPMIKKVG-P--DSD T_rubripes_ENSTRUP00000030645 -------------------------------------KRLLHRGEK-S--DSD G_aculeatus_ENSGACP00000008676 NRPGVVGTSGMAATNDEWADFGFDM--PDCKLSRSS-RHSIKEEFMES--DVH O_latipes_ENSORLP00000019616 PR-------------DEWSDFSFDL--DSTK---SR-EQEFKQSNS------- T_nigroviridis_ENSTNIP00000016776 PR-------------DEWSDFSFDL--DSRR---NK-QQRIKEEGE------- T_rubripes_ENSTRUP00000008025 PR-------------DEWSDFSFDL--DSRR---NK-QQRIKEEGE------- T_nigroviridis_ENSTNIP00000013035 -------------------------------------KRLMHRGEK-S--DSD T_rubripes_ENSTRUP00000038165 HRPGVVGTSGMTAAADEWADFGFDM--PDCKLS-CS-KHSIKEEFMES--DVH D_rerio_ENSDARP00000074096 NRGPANG-------PEEWPDFGFDM--PDCR---LH-KHSIKEEFAEG--DVH X_tropicalis_ENSXETP00000010981 NRGG----------ADEWADFGFDL--PDCK---SR-KQSIKEEYENS--DIN O_anatinus_ENSOANP00000021753 PR-------------DEWNDFNFDM--DARR---NK-QQRIKEEGE------- C_familiaris_ENSCAFP00000028819 NRGGPGGGSG----PDEWADFGFDL--PDCK---SR-KQSIKEEFTES--EIN C_familiaris_ENSCAFP00000020585 PR-------------DEWNDFNFDM--DARR---NK-QQRIKEEGE------- O_latipes_ENSORLP00000005521 NRSG-VGTAGMAAAADEWADFGFDM--PDCKVS-RN-KHSIKEEFMES--DVH B_taurus_ENSBTAP00000007643 NRGGPAGGAG----PDEWADFGFDL--PDCK---SR-KQSIKEEFTES--EAN M_domestica_ENSMODP00000018831 PR-------------DDWNDFNFDM--DARR---NK-QQRIKEEGE------- R_norvegicus_ENSRNOP00000033463 PR-------------DEWNDFNFDM--DSRR---NK-QQRIKEEGE------- M_musculus_ENSMUSP00000110965 PR-------------DEWNDFNFDM--DSRR---NK-QQRIKEEGE------- O_cuniculus_ENSOCUP00000014157 PR-------------DEWNDFNFDM--DARR---NK-QQRIKEEGE------- M_musculus_ENSMUSP00000101269 NRGGAGAVTG----PDEWADFGFDL--PDCK---SR-KQPIKEEFTET--ESH G_aculeatus_ENSGACP00000018012 A------------------------------------EHRML----------- P_pygmaeus_ENSPPYP00000016106 PR-------------DEWNDFNFDM--DARR---NK-QQRIKEEGE------- M_mulatta_ENSMMUP00000021634 PR-------------DEWNDFNFDM--DARR---NK-QQRIKEEGE------- H_sapiens_ENSP00000264731 PR-------------DEWNDFNFDM--DARR---NK-QQRIKEEGE------- P_troglodytes_ENSPTRP00000027067 PR-------------DEWNDFNFDM--DARR---NK-QQRIKEEGE------- R_norvegicus_ENSRNOP00000052265 NRGGAGGVTG----PDEWADFGFDL--PDCK---SR-KQPIKEEFTET--ESH E_caballus_ENSECAP00000016315 PR-------------DEWNDFNFDM--DARR---NK-QQRIKEEGE------- H_sapiens_ENSP00000367545 NRGGPGG--G----PDEWADFGFDL--PDCK---AR-KQPIKEEFTEA--EIH G_gallus_ENSGALP00000011836 PR-------------DEWNDFNFDM--DARR---NK-QQRIKEEGE------- T_guttata_ENSTGUP00000002829 NRGA----------ADDWADFGFDL--PDCK---SR-KQSIKEEFTEG--EIN D_rerio_ENSDARP00000065136 PR-------------DDWTDFSFDLAPDSRR---NK-QQRIKEEGE------- T_guttata_ENSTGUP00000009686 PR-------------DEWNDFNFDM--DARR---NK-QQRIKEEGE------- T_nigroviridis_ENSTNIP00000014938 HRSGAVGTSGMAAAADEWADFGFDM--PDCKLS-CS-KHSIKEEFMES--DVH G_gallus_ENSGALP00000001485 NRGA----------ADEWADFGFDL--PDCK---SR-KQSIKEEFTEG--EIN M_mulatta_ENSMMUP00000021768 NRGGPGA--G----PDEWADFGFDL--PDCK---AR-KQPIKEEFTEA--EIH A_carolinensis_ENSACAP00000001746 NRGG----------ADEWADFGFDL--PDCK---SR-KHSIKEEFTEG--EIN O_latipes_ENSORLP00000008029 -------------------------------------RSAMRTKEEQS--DQT E_caballus_ENSECAP00000006210 -------------------------------------KKLIFKREG-P--DSD E_caballus_ENSECAP00000001313 NRGGPGGGSG----PDEWADFGFDL--PDCK---SR-KQSIKEEFTES----- B_taurus_ENSBTAP00000020544 PR-------------DEWNDFNFDM--DARR---NK-QQRIKEEGEEG--EIR G_gorilla_ENSGGOP00000005012 PR-------------DEWNDFNFDM--DARR---NK-QQRIKEEGE------- G_gorilla_ENSGGOP00000015180 NRGGPGG--G----PDEWADFGFDL--PDCK---AR-KQPIKEEFTEA--EIH C_intestinalis_ENSCINP00000003956 -------------------------------------KQIMTSDLLSQVGYQE M_domestica_ENSMODP00000008216 NRSG----------ADEWADFGFDL--PDCK---SR-KQSIKEEFTDS--EIN C_intestinalis_ENSCINP00000004447 ----------------------------------------------------I A_carolinensis_ENSACAP00000000376 PR-------------DEWNDFNFDL--DARR---NKQQQRIKEEGE------- P_pygmaeus_ENSPPYP00000002277 NRGGPGG--G----PEEWADFGFDL--PDCK---AR-KQPIKEEFTEA--EIH O_anatinus_ENSOANP00000019815 NRGG-----G----ADDWADFGFDL--PDCK---SR-KQSIKEEFTEG--EIN P_troglodytes_ENSPTRP00000000118 NRGGPGG--G----PDEWADFGFDL--PDCK---AR-KQPIKEEFTEA--EIH M_domestica_ENSMODP00000009014 -------------------------------------GKRLLV---------- A_aegypti_AAEL007594-PA -------------------------------------QSKYEP-------FVM A_aegypti_AAEL007595-PA -------------------------------------KSSFALPNSQSSVDSD A_gambiae_AGAP002352-PA -------------------------------------RSKYASSHR------- A_gambiae_AGAP004319-PA -------------------------------------RDALAMSNSQCSVDLL