10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000065554 IYMRTHTQGMTIKPFSLLAIPFPISLSQM----------------------------------------------EILQN-SAFLRGLCRTSG-PADL-QYDNSSELFRISTYAKFPTTA T_rubripes_ENSTRUP00000043752 --LLSPDPPLGGPTFTLILLCFHTKMETL----------------------------------------------VQLKN-NPFLMGLCRNCP-PPDL-QYDNSSELYRISTFARFPT-S T_nigroviridis_ENSTNIP00000012883 --L----PALFEGLLPFILLCFDTKMETL----------------------------------------------VQLKN-NPFLMGLCRNCP-PPDL-QYDNSSELYRISTFARFPS-S O_latipes_ENSORLP00000006992 ----------------------------L----------------------------------------------VQLKN-SKFLMGLCRNGP-PSDL-QYDNSSELFRFSTFARFPT-S G_aculeatus_ENSGACP00000027283 ------------------------------------------------------------------------------KN-NPFLMGLCRNGP-PPDL-QYDNSSELFRISTFARFPA-S T_guttata_ENSTGUP00000013125 ----------------------------L----------------------------------------------NTVED-SPFLTSIMRQSALCDEL-KYDLSCELYRMSTFSTFPMNT O_anatinus_ENSOANP00000016616 -----VHKTTSRGETRPVSPATPTEYFVM----------------------------------------------NVVAN-SMFLSNLMNGNS-GYEL-KYDFSCELFRMSTYSTFPTNV G_gallus_ENSGALP00000035646 ----------------------------M----------------------------------------------NIMDS-SPLLASVMKQNAHCGEL-KYDLSCELYRMSTFSTFPVNV E_caballus_ENSECAP00000000598 -----------------------------------------------------------------------------MED-STILSSWTVGNK--QKM-KYDFSCELYRMSTYSTFPTGV M_mulatta_ENSMMUP00000004536 ----------MHKTASQRLFPGPSYQNIK----------------------------------------------SIMED-STILSDWTNSNK--QKM-KYDFSCELYRMSTYSTFPTGV H_sapiens_ENSP00000227758 ----------MHKTASQRLFPGPSYQNIK----------------------------------------------SIMED-STILSDWTNSNK--QKM-KYDFSCELYRMSTYSTFPAGV P_pygmaeus_ENSPPYP00000004357 ----------MHKTASQRLFPGPSYQN-K----------------------------------------------SIMED-STILSDWTNSNK--QKM-KYDFSCELYRMSTYSTFPAGV P_troglodytes_ENSPTRP00000007251 ----------MHKTASQRLFPGPSYQNIK----------------------------------------------SIMED-STILSDWTNSNK--QKM-KYDFSCELYRMSTYSTFPAGV C_familiaris_ENSCAFP00000022277 ----------MHKTTSQRLVPG-SYQRIK----------------------------------------------RTMED-STILRNQTIGNK--QKI-KYDFSCELYRMSTYSTFPAGV E_caballus_ENSECAP00000010270 ----------------------------M----------------------------------------------NIVEN-SVFLSNLMKSAN-MFEL-KYDFSCELYRISTYSTFPPGV M_domestica_ENSMODP00000000728 -----THKTTSQRKT---CPLLFPKYSIM----------------------------------------------SVVED-GVLLSHLMSSDT--HEM-KYDLSCELYRMSTYSAFPVNV A_carolinensis_ENSACAP00000012475 ----------------------------L----------------------------------------------IIMNTFDTFAAKLKNVPD-VGQL-KYDLSCELFRMSTFSTFPLHV C_familiaris_ENSCAFP00000022282 ----------------------------M----------------------------------------------NIVQN-SIFLSNLLRSSP-VFEL-KYDHSCELYRMSTYSTFPAGV P_troglodytes_ENSPTRP00000007250 ----------------------------M----------------------------------------------NIVEN-SIFLSNLMKSAN-TFEL-KYDLSCELYRMSTYSTFPAGV M_mulatta_ENSMMUP00000004533 ----------------------------M----------------------------------------------NIVEN-SIFLSNLMKSAN-TFEL-KYDLSCELYRMSTYSAFPAGV H_sapiens_ENSP00000376897 ----------------------------M----------------------------------------------NIVEN-SIFLSNLMKSAN-TFEL-KYDLSCELYRMSTYSTFPAGV M_musculus_ENSMUSP00000091422 ----------MDKTVSQRLGQGTLHQKLK----------------------------------------------RIMEK-STILSNWTKESE--EKM-KFDFSCELYRMSTYSAFPRGV P_pygmaeus_ENSPPYP00000004355 ----------------------------M----------------------------------------------NIVEN-SIFLSNLMKSAN-TFEL-KYDLSCELYRMSTYSTFPAGV R_norvegicus_ENSRNOP00000007702 ----------------------------M----------------------------------------------NMVQG-SAFLAKLMKSAD-TFEL-KYDFSCELYRLSTYSTFPAGV R_norvegicus_ENSRNOP00000014560 ----------------------------------------------------------------------------IMEN-STVLSNWTKENK--EKM-KYDFSCELYRMSTYSAFPRGV X_tropicalis_ENSXETP00000048002 --------------------------MAN----------------------------------------------EILDR-RPDLAKRLKSNPSMCKI-TLEFSCELYRLSTFSTFPSNT M_musculus_ENSMUSP00000013949 ----------------------------M----------------------------------------------NMVQD-SAFLAKLMKSAD-TFEL-KYDFSCELYRLSTYSAFPRGV B_taurus_ENSBTAP00000034604 ----------------------------M----------------------------------------------NIVEN-SVFLSNLMKSAN-MFEL-KYDFSCELYRMSTYSTFPAGV O_cuniculus_ENSOCUP00000011948 -----------HKTTSPRVVPG-TVYRTQ----------------------------------------------NMMED-STILXXXXXXXX--XXX-XXXXXXXXXXXXXXXXSPNGV M_domestica_ENSMODP00000000705 ----------------------------M----------------------------------------------NLVEN-IMFLSNMNISNL--YEL-KYDFSCELYRISTYSAFPVNV O_cuniculus_ENSOCUP00000008710 ----------------------------M----------------------------------------------NIVEN-SIFLANLMKSAN-TFEL-KYDFSCELYRMSTYSTFPAGV D_rerio_ENSDARP00000075338 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000014265 -----MHKTASQRVV------PGTSYRIK----------------------------------------------SMMED-STISSNTNDQNQ---KM-KYDFSYKI-RVPTYSGLPIRV G_gorilla_ENSGGOP00000008137 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000046955 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000110746 --------------------------MTF----------------------------------------------NSFEGTRTFVLA-------DTNK-DEEFVEEFNRLKTFANFPSSS R_norvegicus_ENSRNOP00000009358 --------------------------MTF----------------------------------------------NSFEGSRTVVPA-------DTNK-DEEFVEEFNRLKTFANFPSSS C_familiaris_ENSCAFP00000034255 --------------------------MTF----------------------------------------------NSFEGAKTCVPA-------GINK-DEEFVEEFNRLKTFANFPSSS P_pygmaeus_ENSPPYP00000023167 --------------------------MTF----------------------------------------------NSFEGSKTCVPA-------DINK-EEEFVEEFNRLKTFANFPSGS B_taurus_ENSBTAP00000053449 --------------------------MTF----------------------------------------------NSFEGSKTCVPA-------DIDK-DEEFVEEFNRLKTFANFPSSS C_intestinalis_ENSCINP00000000045 --------------------------------------------------------------------------------------------------------MESYRLSTFMKYPQDT E_caballus_ENSECAP00000017630 --------------------------MTF----------------------------------------------NSFEGSKTCVPA-------DIDK-DEEFVEEFNRLKTFANFPSSS H_sapiens_ENSP00000360242 --------------------------MTF----------------------------------------------NSFEGSKTCVPA-------DINK-EEEFVEEFNRLKTFANFPSGS P_troglodytes_ENSPTRP00000038304 --------------------------MTF----------------------------------------------NSFEGSKTCVPA-------DINK-EEEFVEEFNRLKTFANFPSGS O_cuniculus_ENSOCUP00000008505 --------------------------MTF----------------------------------------------NSFEGSKTCVPA-------DINK-DEEFVEEFNRLKTFANFPSSS G_gallus_ENSGALP00000038337 --------------------------MTC----------------------------------------------NGPDSSESGATP-------ATDG-DQEWTQEHYRLGTFVEFPHDC M_domestica_ENSMODP00000018715 --------------------------MTF----------------------------------------------KSFEDSKTCVPP-------DINK-DEDFVEEFNRLKTFANFPSSS T_guttata_ENSTGUP00000003825 --------------------------AD-------------------------------------------------------------------TDG-AREWAQERERQGTFVGFPQGC C_intestinalis_ENSCINP00000005161 -----------------------------------------------------------------------------------------------------DSAMESYRLSTFMKYPQDT T_nigroviridis_ENSTNIP00000006583 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035327 ------------------------------------------------------------------------LAEFVLKEEMTCQCPKMSDGAYDMDV-DQNYFEEEVRLASFANFPSSY G_aculeatus_ENSGACP00000003419 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000011958 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000005705 ----------------------------M----------------------------------------------NIVEN-SIFLSNLMKSAN-TFEL-KYDLSCELYRMSTYSTFPAGV C_intestinalis_ENSCINP00000009820 -----------------------------------------------------------------------------------------------------DAAMESYRLSTFMKYPQDT X_tropicalis_ENSXETP00000030727 ----------------------------N----------------------------------------------EILDR-RPDLAKRLKSNPSMCKI-TLEFSCELYRLSTFSSFPSNT O_latipes_ENSORLP00000010149 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000029187 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000010298 ---------------------------------------------------------------------MNPFDNMQLKKEITMEDQQHDSGTLETDS-AEDFSLITSRLESFRGSNLVQ O_anatinus_ENSOANP00000006435 --------------------------MTC----------------------------------------------NSPEELRTSNPS-------EVNK-DEEFAEEHNRLRTFANFPSTS D_melanogaster_FBpp0086432 -------------------------------------------------------------------------------------------------MTELGMELESVRLATFGEWPLNA G_gorilla_ENSGGOP00000008442 --------------------------MTF----------------------------------------------NSFEGSKTCVPA-------DINK-EEEFVEEFNRLKTFANFPSGS A_carolinensis_ENSACAP00000011315 ---------------------------------------------------------------------------------------------------------ELSRQQTFASFPSDC A_aegypti_AAEL006633-PA ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000018867 -----------------------------------------------------------------------------------MEDQRHDNSNLETDS-AEDFSLIKSRLESFRGSSLVQ D_rerio_ENSDARP00000013586 -------------------------------------------------------------------------FPPQRNLVTTNMAHSTHNGELESDNVAADWSVMKNRVNSFQRFPYSE G_aculeatus_ENSGACP00000024474 -------------------------------------------------------------------------VPPSSILSSSIMCALRQDNQLESDH-MADFSEINNRLDSFRGSSLAQ O_latipes_ENSORLP00000012199 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000002256 --------------------------------------------------------------------------------------------------------MESYRLSTFMKYPQDT G_gallus_ENSGALP00000009239 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000007779 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000021022 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000000487 --------------------------------------------------------------------------------------------------------M--------------- H_sapiens_ENSP00000321377 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000019640 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000000510 --------------------------------------------------------------------------------------------------------M--------------- C_intestinalis_ENSCINP00000021651 --------------------------MLV----------------------------------------------DSFCSNLKYQTMFHNIDRVSQHAAAMDYSSKSNRIQSLENFP-SA G_gorilla_ENSGGOP00000007398 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000000466 ------------------------------------------------------------------MELANNLFSDIETDGMKVNTTSEPSDKRCVYITPGQKEREDYRITTFNKFPSNK X_tropicalis_ENSXETP00000016315 ---------------------------------------------------------------------------------------------------------------------KHF X_tropicalis_ENSXETP00000016312 ----------------------------------------------------------------------------------------YSGSQNPGEKPLGDMNDEYSRLETYRGHSQYF M_musculus_ENSMUSP00000112867 ----------------------------------------------MAEHGESSEDRISEIDYEFLAELSARFGMNLVQLAKSQEEEDHKERMKMKKGFNSQMRSEAKRLKTFESYDTFR G_gorilla_ENSGGOP00000008152 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000058611 ----------------------------------------------MAEHGESSEDRISEIDYEFLPELSALLGVDAFQVAKSQEEEEHKERMKMKKGFNSQMRSEAKRLKTFETYDTFR C_intestinalis_ENSCINP00000020067 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000022142 ----------------------------------------------MAEHGESSEDRISEIDYEFLPELSALLGVDAVQLAKSQEEEEHKERMKMKKGFNSQMRSEAKRLKTFETYDTFR X_tropicalis_ENSXETP00000057704 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000217169 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000023641 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000034890 ---------------------------------------------------------------------------------------------------------------------KHF B_taurus_ENSBTAP00000004317 ----------------------------------------------MATQEKAPEERISQFDYALLPEMSAFLGVNALQFVKEIEEKEHRDREKMQKGFNSQMRSEAKRLKTFVTYNTFR M_mulatta_ENSMMUP00000012096 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000048273 ----------------------------------------------MATQQKASDERISQFDHNLLPELSALLGLDAGQLAKELEEKEQKERAKMQKGYNSQMRSEAKRLKTFVTYEPYS M_musculus_ENSMUSP00000113890 ----------------------------------------------MAAQGEAVEEIICEFDDDLVSELSTLLRVDALSVLKRQQEEDHKTRMKMKKGFNSQMRSEAKRLKTFETYDKFR R_norvegicus_ENSRNOP00000024483 ----------------------------------------------MAEHGEASEDQVSEFDGECLPELSALLGVDAVQLVKSQEEEENKERMKMKKGFNAQMRSEAKRLKTFVTYDAFK H_sapiens_ENSP00000194097 ----------------------------------------------MATQQKASDERISQFDHNLLPELSALLGLDAVQLAKELEEEEQKERAKMQKGYNSQMRSEAKRLKTFVTYEPYS C_intestinalis_ENSCINP00000010449 ---------------------------------------------------------------MQARMMDIRCDGLRVVHNDGRLVPSATNSERELYTRPGDPYYESYRLATFTNYP-NQ M_musculus_ENSMUSP00000104503 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000017359 ----------------------------------------------MATQQKASDERISQFDHDLLPELSALLGLDAVQFVKEIEEEEQKERAKMQKGYNSQMRSEAKRLKTFVTYEPYS P_pygmaeus_ENSPPYP00000012543 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017749 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0075254 ------------------------------------------------------------------------------------------------------------MASVVADLPSYG A_aegypti_AAEL009074-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000018803 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000005440 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000002314 ----------------------------------------------MATEEKAPAGRDSRFDHALLQELSALLGIDAVQYAKEMEEEEQREREKMQQGFNSRMRSEAKRLKTFATYEAYS C_intestinalis_ENSCINP00000011648 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP007293-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP007291-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP007292-PA ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002871 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000002312 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000008701 MKQRHKYLHNTRKSTAPFNNQINGNAKDKRNYEKKSLKSTLGSKGLHELCLFETFNPEVCKIHPEIKGKSYKSGGKKLRESANTDVQSDGTPAANDDNIAPTPERASEMVFRLLSFKERS A_gambiae_AGAP011326-PA ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000000543 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000002056 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000264198 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000009065 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013139 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000000497 ------------------------------------------------------------------------------------------------------------------------ 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000065554 AVT-ERSLARAGFYYTGLGDRVQCFRCNVTADNWQSGDCPAERHKQLSPNCSFIQSLPAT--ANLLSSSHS-------------------------AFSPLRNVAVLQLSAPATAAPSTT T_rubripes_ENSTRUP00000043752 GVT-ERSLARAGWFYTGVGDRVQCFKCNVTAEGWQAGDCPTEKHRQLSPSCSFIQSLPST--SNLLSSSHS-------------------------AFSPLRIAPAIPLSG---AGPAVP T_nigroviridis_ENSTNIP00000012883 GVT-ERSLARAGWFYTGVGDRVQCFKCNVTAEGWQAGDCPTEKHRQLSPSCTFIQSLPST--SNLLSSSHS-------------------------AFSPLRIAPAIPLSG---AGPAVP O_latipes_ENSORLP00000006992 VVT-ERSLARAGWFYTGVGDRVQCFRCNVTAEGWLAGDCPTEKHRQLSPTCPFIQSLPST--TNLLSSSHS-------------------------AFSPLRIAQAMPVSSERRQGPAAS G_aculeatus_ENSGACP00000027283 GVT-ERSLARAGWFYIGVGDRVQCFRCNVTAEGWQAGDCPTEKHRQLSPTCSFIQSLPST--TNLLSSSHS-------------------------AFSPLRIAPAV------------- T_guttata_ENSTGUP00000013125 PVS-ERSLARAGFYYTGVQDKVKCFSCGLTLDNWQPGDNAMEKHKQLYPRCSFVQRMLSD--NNVGLSSRS-------------------------AFSPSIANS---------LPPSLH O_anatinus_ENSOANP00000016616 PVS-ERSLARAGFYYTGASDKVKCFSCGLMLDNWKPGDSAIEKHKQLYPSCSFIQNLLQT--HNPGASSYS-------------------------AFCPPPLGS------------LSP G_gallus_ENSGALP00000035646 PVS-ERRLARAGFYYTGVQDKVKCFSCGLVLDNWQPGDNAMEKHKQVYPSCSFVQNMLSL--NNLGLSTHS-------------------------AFSPLVASN---------LSPSLR E_caballus_ENSECAP00000000598 PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKQGDNPIEKHKQLYPSCSFIQNLVSV--TSLESTSKN-------------------------TSSPMRNSF--------------- M_mulatta_ENSMMUP00000004536 PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIEKHKQLYPSCSFIQNLVS---ATLGSTSKN-------------------------T-SPMRNSF--------------- H_sapiens_ENSP00000227758 PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVS---ASLGSTSKN-------------------------T-SPMRNSF--------------- P_pygmaeus_ENSPPYP00000004357 PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVS---ASLGSTSKN-------------------------T-SPMRNSF--------------- P_troglodytes_ENSPTRP00000007251 PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVS---ASLGSTSKN-------------------------T-SPMRNSF--------------- C_familiaris_ENSCAFP00000022277 PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKPGDNPVEKHKQLYPSCSFIHSLVSL--TSRDSTSKN-------------------------I-SAMRNSF--------------- E_caballus_ENSECAP00000010270 PVS-ERSLARAGFYYTGINDRVKCFCCGLMLDNWKQGDNPTEKHKKLYPSCSFVQNLNSV--NISGATSQL-------------------------AFSSSVTNS--------------- M_domestica_ENSMODP00000000728 PIS-ERSLARAGFYYTGVNDRVKCFCCGLMLDNWKQGDNAIDKHKQLYPSCAFIQNLISV--N--LGSSQS-------------------------TFSSSVNNA--------------- A_carolinensis_ENSACAP00000012475 PVS-ERSLARAGFYYTGVKDKVKCYSCGLMLDNWKKGDNPLDKHKQLYPSCSVVQNLTSL--NNLGSSFYS-------------------------AFSPPSLSV---------GHSSSH C_familiaris_ENSCAFP00000022282 PVS-ERSLARAGFYYTGAKDRVRCFCCGLMLDNWKAGDSPTGKHRNLYPSCSFIQNLSAV--STVGAASQP-------------------------PAPLSEARS--------------- P_troglodytes_ENSPTRP00000007250 PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPIEKHKKLYPSCRFVQSLNSV--NNLEATSQP-------------------------TFPSSVTNS--------------- M_mulatta_ENSMMUP00000004533 PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPVEKHKKLYPSCRFVQSLNSV--NNSEATSQP-------------------------AFPSSVTNS--------------- H_sapiens_ENSP00000376897 PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSV--NNLEATSQP-------------------------TFPSSVTNS--------------- M_musculus_ENSMUSP00000091422 PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKQGDSPVEKHRQFYPSCSFVQTLLS---ASLQSPSKN-------------------------M-SPVKSRF--------------- P_pygmaeus_ENSPPYP00000004355 PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPIEKHKKLYPSCRFVQSLNSV--NNLEATSQP-------------------------TFPSSVTNS--------------- R_norvegicus_ENSRNOP00000007702 PVS-ERSLARAGFYYTGVNDKVKCFSCGLMLDNWKQGDSPIEKHRKLYPSCSFVQTLNPA--NSLEASPQP-------------------------PLPSTATST--------------- R_norvegicus_ENSRNOP00000014560 PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKQGDSPTEKHRQFYPSCSFVQTLLS---GGLQSAAKN-------------------------T-SPAKSRF--------------- X_tropicalis_ENSXETP00000048002 HVS-ERNLAKAGFYYTGQDDKVKCFTCGLMLDNWKKGDNAFEKHKKLYPSCSFIQNVPSV---NLGASLYS-------------------------AFSPPASNS---------TP---- M_musculus_ENSMUSP00000013949 PVS-ERSLARAGFYYTGANDKVKCFCCGLMLDNWKQGDSPMEKHRKLYPSCNFVQTLNPA--NSLEASPRP-------------------------SLPSTAMST--------------- B_taurus_ENSBTAP00000034604 PVS-ERSLARAGFYYTGVKDKVKCFCCGLMLDNWKQGDNPIEKHKKLYPSCSFVQNLNSI--NVSGASSQP-------------------------TFHYSLTNS--------------- O_cuniculus_ENSOCUP00000011948 PVS-ERSLARAGFYYTRVNDKVKCFCCGLMLDNWKQGDNPIEKHKQLYPSCSFIQNLVS---ASLDSTIKN-------------------------T-SPVRSSF--------------- M_domestica_ENSMODP00000000705 PVS-ERSLARAGFYYTGVNDRVKCFCCGLMLDNWKQGDNAIDKHKQLFPSCAFIQNLTSV--NNLESNSQS-------------------------ALSSSLNSA--------------- O_cuniculus_ENSOCUP00000008710 PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKQGDKPIEKHRKLYPSCSFVQSLNSV--NNWEANSRS-------------------------TFPSSVTNS--------------- D_rerio_ENSDARP00000075338 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000014265 PLS-EWSLAPAGLYYIGMN-KVKCFCCDLMLDNWKQEYNLIEKHKQLYPSCSFSQNLISV---SLESPLRS-------------------------SF---------------------- G_gorilla_ENSGGOP00000008137 -----------------------------------------------------------------------------------------------------RNSF--------------- B_taurus_ENSBTAP00000046955 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000110746 PVS-ASTLARAGFLYTGEGDTVQCFSCHAAIDRWQYGDSAVGRHRRISPNCRFINGFYFENGA-AQSTNPG-------------------------IQNGQY-KS--------------- R_norvegicus_ENSRNOP00000009358 PVS-ASTLARAGFLYTGEGDTVQCFSCHAAVDRWQYGDSAVGRHRRISPNCRFINGFYFENGA-TQSTSPG-------------------------IQNGQY-KS--------------- C_familiaris_ENSCAFP00000034255 PVS-ASTLARAGFLYTGEGDTVRCFSCHASIDRWQYGDSAVGRHRKVSPNCRFINGFYFENTA-AQPTNPG-------------------------IQNGQY-NA--------------- P_pygmaeus_ENSPPYP00000023167 PVS-ASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSA-TQSTNSG-------------------------IQNGQY-KV--------------- B_taurus_ENSBTAP00000053449 PVS-ASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAIGRHRRVSPNCRFINGFYFENNA-AQPTYSG-------------------------VQNGQY-KA--------------- C_intestinalis_ENSCINP00000000045 PVN-PRHLAAAGFHYTGYKDRVKCFCCGLCVESWCVGDD-VKSPRWHRSNCEFILGQDCG---NQPIGSQN-------------------------ISVQQTARPV----PAGMIMKS-- E_caballus_ENSECAP00000017630 PVS-ASTLARAGFLYTGEGDTVQCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYFENNA-AQPTNPG-------------------------VQNGQY-KV--------------- H_sapiens_ENSP00000360242 PVS-ASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSA-TQSTNSG-------------------------IQNGQY-KV--------------- P_troglodytes_ENSPTRP00000038304 PVS-ASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSA-TQSTNSG-------------------------IQNGQY-KV--------------- O_cuniculus_ENSOCUP00000008505 PVS-ASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYFENSA-AQSTNPG-------------------------VQNGQY-KG--------------- G_gallus_ENSGALP00000038337 PVS-ASALARAGFVYTGEGDKVKCFSCHVTVEGWEPGDSAIDRHKNLSPDCRFITGSAFLENN-V---HPL-------------------------VQSHQH-RT--------------- M_domestica_ENSMODP00000018715 PIS-ASTLARAGFLYTGEGDTVKCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYFEKNA-TRFPNPI-------------------------IQNCQY-RV--------------- T_guttata_ENSTGUP00000003825 PVS-VLALAQAGFVYTGEGDKVKCFSCNTTIEGWVPGDSALERHKKLAPTCKFITESAFLKSD-M---DPV-------------------------AQNYQN-RT--------------- C_intestinalis_ENSCINP00000005161 PVN-PRHLATAGLYFTGYKDRVKCFCCGLATEQWQFGDD-EKSPRWHRSNCEFIQGHDCG---NIPIGLHC-------------------------VVKYKLLMEL----TIPIFLGSWG T_nigroviridis_ENSTNIP00000006583 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035327 PVS-APALARAGFYYTGDGDRVKCFSCLAMVEGWQHGDTAIGKHRKISPNCKFINGFNNLRSDCILTQVPV------------------------------------------------- G_aculeatus_ENSGACP00000003419 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000011958 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000005705 PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPIEKHKKLYPSCRFVQSLNSV--NNLEATSQP-------------------------TFPSSVTNS--------------- C_intestinalis_ENSCINP00000009820 PVN-PRHLAAAGFHYTGYKDRVKCFCCGLCVENWVSGDE-IKSKKWHRNNCELVNGNGSG---NQPIAGDD-------------------------F--KSTISPLCECKALSMVLKT-- X_tropicalis_ENSXETP00000030727 HVS-ERNLAKAGFYYTGQDDKVKCFTCGLMLDNWKKGDNAFEKHKKLYPSCSFIQNVPSV---NLGASLYS-------------------------AFSPPASNS---------TP---- O_latipes_ENSORLP00000010149 -VS-PLQLAEAGFLFTGVSDRVRCFSCQKTVENWSQEDQPVDRHIQVSPSCTFLRCTHFNRFK--------------------------------------------------------- X_tropicalis_ENSXETP00000029187 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000010298 LVP-AERLARAGFHFIGPSDRVRCFSCHKTVENWCTGDRPVERHKEVSPFCKFLSCIYRTSSN--------------------------------------------------------- O_anatinus_ENSOANP00000006435 PVS-SSTLARAGFLYTGEEDVVRCFSCHVAVDRWQYGDSAIGRHRKISPNCRFVNGCHFKNCA-LPLANAS-------------------------LQNGELGQV--------------- D_melanogaster_FBpp0086432 PVS-AEDLVANGFFATGNWLEAECHFCHVRIDRWEYGDQVAERHRRSSPICSMVLAPNHCGNV--------------------------------------------------------- G_gorilla_ENSGGOP00000008442 PVS-ASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSA-TQSTNSG-------------------------IQNGQY-KV--------------- A_carolinensis_ENSACAP00000011315 PVS-SAALAQAGFFYTGERDQVKCFSCHTMVEGWQEGDSAIERHRTIFPECRFINDIDIGRNNTYS------------------------------LLNCQHAS---------------- A_aegypti_AAEL006633-PA ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000018867 RVP-AERLARAGFYLVGPSDRVRCFSCQKTVENWSREDRPVERHKEVSPVCQFLSCIYGTRPH--------------------------------------------------------- D_rerio_ENSDARP00000013586 DIS-AQRLARAGFYFTGEGDRVQCFSCSATVQNWNRGDTPLERHQLASPDCRFLSCAHGMRNS--------------------------------------------------------- G_aculeatus_ENSGACP00000024474 QVP-AERLARAGFYYTGNADRVCCFSCEKTVENWCRGDTPLERHKEVSPSCIFLSCTQRTNFN--------------------------------------------------------- O_latipes_ENSORLP00000012199 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000002256 PVN-PRHLAAAGFHYTGYKDRVKCFCCGLCVESWCVGDD-VKSPRWHRSNCEFILGQDCG---NQPI-DHM-------------------------VWLQVVCSAT----LCDHLVQL-- G_gallus_ENSGALP00000009239 -----------------------------------MADTAPVEGTHLRATC--------------------------------------------------------------------- T_guttata_ENSTGUP00000007779 -----------------------------------MGDAAPAQQPEPRAAR--------------------------------------------------------------------- M_domestica_ENSMODP00000021022 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000000487 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000321377 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000019640 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000000510 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000021651 PVN-PIQLAIHGFYFTGVEDCVVCFSCENSVRNWKLGDKEGDK-KWHKPDCVFFNSLSQTVND--------------------------------------------------------- G_gorilla_ENSGGOP00000007398 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000000466 PVD-KMKLSSNGFLYTGFKDRVKCFRCGQCVEGLNGTEN-MGLPGWHKPDCEFANGTDTTNVPLLRHKIQ-------------------------------------------------- X_tropicalis_ENSXETP00000016315 PYQTSDKLAWAGFFYVGPGDRVRCFSCGGEVDNWEPGDVPLTRHQLFFPHCSYVQGLS-------------------------------------------------------------- X_tropicalis_ENSXETP00000016312 PMANQRKLAQAGFSYVGPGDRVRCISCGGELEKWERWDVPLTRHQHSFPHCPYMQKLRDEGDG--------------------------------------------------------- M_musculus_ENSMUSP00000112867 SWT-PQEMAAAGFYHTGVKLGVQCFCCSLILFGNSLRKLPIERHKKLRPECEFLQGKDVGNIG--------------------------------------------------------- G_gorilla_ENSGGOP00000008152 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000058611 SWT-PQEMAAAGFYHTGVRLGVQCFCCSLILFGNSLRKLPIERHKKLRPECEFLQGKDVGNIG--------------------------------------------------------- C_intestinalis_ENSCINP00000020067 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000022142 SWT-PQEMAAAGFYHTGVKLGVQCFCCSLILFGNSLRKLPIERHKKLRPECEFLQGKDVGNIG--------------------------------------------------------- X_tropicalis_ENSXETP00000057704 ----QNKLANAGFYYVGPEDRVRCFSCGGQFEMWEEWDFPLTRHQQTFPECPYLQELKAKGEW--------------------------------------------------------- H_sapiens_ENSP00000217169 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000023641 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000034890 PYMKEWDLAQAGFYYVGPGDRVRCISCNAELEKWEKWDEPLTRHQHSFPDCAYVQEQRAQTTG--------------------------------------------------------- B_taurus_ENSBTAP00000004317 SWT-SQEMAEAGFYLTGTKSGIQCFCCSLILFGTSLQNTPMEHHKKFHPDCEFLLGKDVGNIA--------------------------------------------------------- M_mulatta_ENSMMUP00000012096 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000048273 SWI-PQEMAASGFYFTGVKSGIQCFCCSLILFGAGLTRLPIEDHKRFHPDCGFLLNKDVGNIA--------------------------------------------------------- M_musculus_ENSMUSP00000113890 SWT-PQEMAAAGFYHTGVKLGVQCFCCSLILFSTRLRKLPIENHKKLRPECEFLLGKDVGNIG--------------------------------------------------------- R_norvegicus_ENSRNOP00000024483 SWT-PQEMAAAGFYYTGVRHGVQCFCCSLILFGTSLRKVPIESHRKLRPQCEFLSGKDVGNIG--------------------------------------------------------- H_sapiens_ENSP00000194097 SWI-PQEMAAAGFYFTGVKSGIQCFCCSLILFGAGLTRLPIEDHKRFHPDCGFLLNKDVGNIA--------------------------------------------------------- C_intestinalis_ENSCINP00000010449 NIN-VRQVARAGFYFISYQDQVKCFSCGQICEDLQQYDD-MSLPQWHLPDCEHLHSLQPNRNNHANTPVQS------------------------------------------------- M_musculus_ENSMUSP00000104503 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000017359 SWI-PQEMAAAGFYFTGVKSGIQCFCCSLILFGAGLTRLPIEDHKRFHPDCGFLLNKDVGNIA--------------------------------------------------------- P_pygmaeus_ENSPPYP00000012543 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017749 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0075254 PIA--------------------------------------------------------------------------------------------------------------------- A_aegypti_AAEL009074-PA ---------MAGVMMAQVLSTPRDFT---------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000018803 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000005440 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000002314 SWT-PQEMAAAGFHFTGVRAGVQCFCCGLILFGASLHKRPLDDHKRLRPDCGFLLGEDVGNVA--------------------------------------------------------- C_intestinalis_ENSCINP00000011648 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP007293-PA ----------------MASAVVSCIC---------------------------------------------------------------------------------------------- A_gambiae_AGAP007291-PA ----------------MASTVVSCIC---------------------------------------------------------------------------------------------- A_gambiae_AGAP007292-PA ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002871 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000002312 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000008701 DLN-GKNLTNSGFYLEPGGSVIRCYSCGFRVENVTDTDS-GDSAQYHNDDCAHFKQLQSKQPIALKAPPQPPSVEGASFLPSMMDDLDLGLGNQDLQFSIYDPSLTEPYSGFSFENDQKL A_gambiae_AGAP011326-PA ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000000543 -MESGGKPSLGQFILLGTSSVVTAVLYSVYRQKAQ------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000002056 -MESGGRPSLCQFILLGTTSVVTAALYSVYRQKAR------------------------------------------------------------------------------------- H_sapiens_ENSP00000264198 -MESGGRPSLCQFILLGTTSVVTAALYSVYRQKAR------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000009065 -MENGGRPSLCQFILLGTTSVVTAALYSVYRQKAR------------------------------------------------------------------------------------- E_caballus_ENSECAP00000013139 -MEGGGRPSLGQVILLGTSSVVTAILYSVYRQKAQ------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000000497 -MESGGRPSLCQFILLGTTSVVTAALYSVYRQKAR------------------------------------------------------------------------------------- 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000065554 APSTSGQTEEQVGYLNMGFTNLAPSSPISSRGVEDMSHQRPPACHNPG-MRREQERLDTFQ-NWT-----------------------------------------LA---TVTPAELAK T_rubripes_ENSTRUP00000043752 NPS-ANQGEEPVGYLNMGFSAPPPSSPLISRGVEDMSHQR-PTCHNPN-MRREQDRLESFH-SWT-----------------------------------------LT---IITPAELAK T_nigroviridis_ENSTNIP00000012883 NPS-ANPGEEPVGYLNMGFSAPPPSSPLGSRGVEDMSHQR-PTCHNPN-MRREQDRLDSFH-SWT-----------------------------------------LT---IITPAELAK O_latipes_ENSORLP00000006992 NPS-GGQSEEAVGYLNMAFSAPPPSSPLASRGVEDLSHQR-PTCHNPS-MRREQDRLDSFQ-PWA-----------------------------------------IS---IITPAELAK G_aculeatus_ENSGACP00000027283 -PA-VSQGEEPVGYLNMGFSAPPPSSPLSSRGVEDMSHQR-PTCHNPS-KRKEQDRLDSFH-PWT-----------------------------------------LS---IITPSELAK T_guttata_ENSTGUP00000013125 SIA-LSPSLEQVGYFSGSFSS-FPQDPVTTRAAEDLSFLS-PKLHNNS-MRTEDARLCTFQ-SWP-----------------------------------------LT---FLSPTDLAK O_anatinus_ENSOANP00000016616 TAT-ISPSLEPSGYFSGSFSS-FPLDPVTSRAIEDLSQPR-PHVDNSA-MSSEEARICTFQ-SWP-----------------------------------------LT---FLSPSALAK G_gallus_ENSGALP00000035646 SMT-LSPSFEQVGYFSGSFSS-FPQDPVTTRAAEDLSHLR-SKLHNPS-MSTEEARLRTFH-AWP-----------------------------------------LM---FLSPAELAK E_caballus_ENSECAP00000000598 THS-LSPTLEHSGSFSGSYSN-LSPNLVNSRAVEDFSPLR-TNPYSYA-MSTEEARFLTYH-MWP-----------------------------------------LT---FLSPSELAR M_mulatta_ENSMMUP00000004536 AHS-LSPTLEHSSLFSGSYSS-LSPNPLNSRAVEDLSPSR-TNPYSYA-MSTEEARFLTYH-MWP-----------------------------------------LT---FLSPSELAR H_sapiens_ENSP00000227758 AHS-LSPTLEHSSLFSGSYSS-LSPNPLNSRAVEDISSSR-TNPYSYA-MSTEEARFLTYH-MWP-----------------------------------------LT---FLSPSELAR P_pygmaeus_ENSPPYP00000004357 AHS-LSPTLEHSSLFSGSYSS-LSPNPLNSRAVEDFSSSR-TNPYSYA-MSTEEARFLTYH-MWP-----------------------------------------LT---FLSPSELAR P_troglodytes_ENSPTRP00000007251 AHS-LSPTLEHSSLFSGSYSS-LSPNPLNSRAVEDISSSR-TNPYSYA-MSTEEARFLTYH-MWP-----------------------------------------LT---FLSPSELAR C_familiaris_ENSCAFP00000022277 THS-ISPTLEH-GSFSGSHSN-LAANPVSSRAGEDFSPLS-TNPYSYA-MSTEEARFLTYH-MWP-----------------------------------------LT---FLSPSDLAR E_caballus_ENSECAP00000010270 THS-LLPSLENSGYFSGSYSS-FPSNPVNSGPNHDFSALR-TSPYHCA-MNTEKARLLTFQ-MWP-----------------------------------------LT---FLSPTDLAK M_domestica_ENSMODP00000000728 TRS-LSLSSEQSGYFSGSYSS-FPLEPVTSRGVEDLSPLN-TSPYSYS-MSTEEARILTYQ-AWP-----------------------------------------LT---FLSPLDLAR A_carolinensis_ENSACAP00000012475 SPQ-QTPNLDQVGYFSGSFSS-VPQEL--PKLTEGISHVR-PKVANSA-MSSEEARLLTFK-TWP-----------------------------------------LT---FLSPSSLAK C_familiaris_ENSCAFP00000022282 THA-QSPGLERSSYFSASYSS-FPVDPVDFRPSPAMSPWR-AGPSCVT-MKSEEDRLCTFQ-GWP-----------------------------------------LA---FPLPSALAR P_troglodytes_ENSPTRP00000007250 THS-LLPGTENSGYFGGSYSN-SPSNPVNSRANQDFSALM-RSSYHCA-MNNENARLLTFQ-TWP-----------------------------------------LT---FLSPTDLAK M_mulatta_ENSMMUP00000004533 THS-LLPGTENSGYFSGSYSS-FPSNPVNSRANQDFSALM-RSSYHCA-MNNEKARLLTFQ-TWP-----------------------------------------LT---FLSPTDLAK H_sapiens_ENSP00000376897 THS-LLPGTENSGYFRGSYSN-SPSNPVNSRANQDFSALM-RSSYHCA-MNNENARLLTFQ-TWP-----------------------------------------LT---FLSPTDLAK M_musculus_ENSMUSP00000091422 AHS-SP--LER----GGIHSN-LCSSPLNSRAVEDFS-SR-MDPCSYA-MSTEEARFLTYS-MWP-----------------------------------------LS---FLSPAELAR P_pygmaeus_ENSPPYP00000004355 THS-LLPGTENSGYFSGSYSS-FPSNPVNSRVNQDFSALM-RSSYHCA-MNNENARLLTFQ-TWP-----------------------------------------LT---FLSPTDLAK R_norvegicus_ENSRNOP00000007702 MPS-GFAASESTGYFSGSYSS-FPSDPVNFRANQDCPAFS-TSPYHFA-MNTEKARLLTYQ-TWP-----------------------------------------LS---FLSPAELAK R_norvegicus_ENSRNOP00000014560 AHS-LP--LEQ----GGIHSS-LPSNPLNSRAVEDFS-LR-MNPCSYA-MSTEEARFLSYS-MWP-----------------------------------------LS---FLSPAELAK X_tropicalis_ENSXETP00000048002 MHA-ASAENDKVEAITLKYSS-IPQDPVTLRGIEDLSHVR-ISEY----MYTEEARLNSFQ-EWS-----------------------------------------NM---FLTPAELAK M_musculus_ENSMUSP00000013949 MPL-SFASSENTGYFSGSYSS-FPSDPVNFRANQDCPALS-TSPYHFA-MNTEKARLLTYE-TWP-----------------------------------------LS---FLSPAKLAK B_taurus_ENSBTAP00000034604 THS-LLPSLENSGYFSGSYSS-FPSNLLNSGPNQDFSALR-ISSYPCA-MNTEKARLLTFQ-MWP-----------------------------------------LT---FLSPTDLAK O_cuniculus_ENSOCUP00000011948 AHS-LSPTVEPGGSFSGSYSS-LSANPLNSRTVEDFSPLR-TNPYSYS-MSSEEARFLTYH-MWP-----------------------------------------LS---FLSPSELAR M_domestica_ENSMODP00000000705 SCS-LSPSSEQSGYFSGSYSS-FPLEPVTSRGVEDLSPLN-TSPYSYS-MSTEEARILTYQ-AWP-----------------------------------------LT---FLSPLDLAR O_cuniculus_ENSOCUP00000008710 THS-FLPSWEHSGYYSGSYSS-LPSNPVNSRANQDFSAFR-VSPYHSA-MSTEKARLLTFQ-SWP-----------------------------------------LT---FLSPMDLAK D_rerio_ENSDARP00000075338 -----------------------------------------------G-MRSEEERLQTFH-NWP-----------------------------------------SDA--AVSPEELAR O_cuniculus_ENSOCUP00000014265 AHP-LFPTQGPCVSFSGSYPS-LSANPPNLTSV-DFSPLR-TS-LGYS-MSTEEAR---FY-YKP-----------------------------------------FS---FLLPSEFAR G_gorilla_ENSGGOP00000008137 AHS-LSPTLEHSSLFSGSYSS-LSPNPLNSRAIEDISSSR-TNPYSYA-MSTEEARFLTYH-MWP-----------------------------------------LT---FLSPSELAR B_taurus_ENSBTAP00000046955 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000110746 --ENCVGNRNPF--APDRPPETHADYLLRTGQVVDISDT--IYPRNPA-MCSEEARLKSFQ-NWP-----------------------------------------DYA--HLTPRELAS R_norvegicus_ENSRNOP00000009358 --ENCVGNRNHF--ALDRPSETHADYLLRTGQVVDISDT--IYPRNPA-MCSEEARLKTFQ-NWP-----------------------------------------DYA--HLSPRELAS C_familiaris_ENSCAFP00000034255 --ENYLRNRDHF--VLDRPSETHADYLLRTGQVVDISDT--TYPENPA-MYSEEARLNSFQ-NWP-----------------------------------------DYV--HLTPRELAS P_pygmaeus_ENSPPYP00000023167 --ENYLGSRNHF--ALDRPSETHADYLLRTGQVVDISDT--IYPRNPA-MYSEEARLKSFQ-NWP-----------------------------------------DYA--HLTPRELAS B_taurus_ENSBTAP00000053449 --ENYLGNRNHF--VLERPSETHAHYLLRTGQVVDLSDT--VYPRNPV-MCSEEARLKSFH-NWP-----------------------------------------DYA--HLTPRELAR C_intestinalis_ENSCINP00000000045 ---GPSEFRFTFVILTF---LTLYSTRPKVELATIASPYHEQLVRSLD-LRKESDRFKTYE-NWP-----------------------------------------AQN-RTVYASDLAR E_caballus_ENSECAP00000017630 --ENYLGNRNHF--VLGRPSETHAEYLLRTGQVVDISDT--IYPRNPA-MCSEEARLKSFQ-NWP-----------------------------------------DYA--HLTPGELAS H_sapiens_ENSP00000360242 --ENYLGSRDHF--ALDRPSETHADYLLRTGQVVDISDT--IYPRNPA-MYSEEARLKSFQ-NWP-----------------------------------------DYA--HLTPRELAS P_troglodytes_ENSPTRP00000038304 --ENYLGSRNHF--ALDRPSETHADYLLRTGQVVDISDT--IYPRNPA-MYSEEARLKSFQ-NWP-----------------------------------------DYA--HLTPRELAS O_cuniculus_ENSOCUP00000008505 --ENYLGNRNHF--ALDRPSETHADYLLRTGQVVDISDT--IYPRNPA-MCSEEARLKSFQ-NWP-----------------------------------------DYA--HLTPRELAS G_gallus_ENSGALP00000038337 --ENGSSNLALPS-ALEDLSDVEADYLLRTRQVVDMSDT--LYPKNPA-MCSEEARLKSFH-NWP-----------------------------------------PYG--LLTPKELAS M_domestica_ENSMODP00000018715 --ENCSRNRNHF--ALERPSETHGEYLLRTGQVIDMSDT--IYPRNPS-MCSEEARLRSFQ-NWP-----------------------------------------DYA--HLTPQELAS T_guttata_ENSTGUP00000003825 --ENGTSNSALPC-ALDD-PDVEADYLLRTRQVVDMSDS--LYPKNPA-MCSEETRLKSFH-NWP-----------------------------------------LND--RLTPQELAN C_intestinalis_ENSCINP00000005161 WIRPDNTARENFMN-VTYLNLGEKNFFQRIELATISSVYHEQVLRSLD-LKKEGERMKSFE-NWP-----------------------------------------TQN-RTVNPSDLAR T_nigroviridis_ENSTNIP00000006583 -------------------------------------------------MRREKDRIRTFR-EWP-----------------------------------------ADA--AVAPADLAK X_tropicalis_ENSXETP00000035327 --MQNGFQNSAEDLAERSSSEIMADYLLRTGRVVDMSTP--KYPRHME-MCSEEARLQTFQ-NWP-----------------------------------------AYS--PLTPKELAN G_aculeatus_ENSGACP00000003419 --------------------------------MTDDRGTAPRAPEAPR-MRGEGERLRTFG-RWP-----------------------------------------ADA--PVTSGELAG T_rubripes_ENSTRUP00000011958 ------------------------------------------MLEEPR-MRREGDRIRTFQ-EWP-----------------------------------------ADA--AVAPADLAR G_gorilla_ENSGGOP00000005705 THS-LLPGTENSGYFSGSXSN-SPSNPVNSRANQDFSALM-RSSYHCA-MNNENARLLTFQ-TWP-----------------------------------------LT---FLSPTDLAK C_intestinalis_ENSCINP00000009820 ---PKIQGCRKFSMPLSFFV--------RIELATIASPYHEQLVRSLD-LRKESDRSKTYE-NWP-----------------------------------------AQN-RTVYASDLAR X_tropicalis_ENSXETP00000030727 MHA-ASAENDKVEAITLKYSS-IPQDPVTLRGIEDLSHVR-ISEY----MYTEEARLNSFQ-EWS-----------------------------------------NM---FLTPAELAK O_latipes_ENSORLP00000010149 ----SNPHMPLSNGGLHDGTEGYIDYQLRTRAIVDET----PYPRNRN-MKSEEARLETFS-SWP-----------------------------------------RSA--PVRPRDLAQ X_tropicalis_ENSXETP00000029187 --------------------------------------------VPPN-MRSEAERQRSFR-AWP-----------------------------------------HTC-RTVSPAELAR T_rubripes_ENSTRUP00000010298 ----PIPGTSLTNGSAYNEEAEDMEYRLRTGQVVDES----IYPVVPH-MRSEESRLHTFS-TWP-----------------------------------------LTA--PVSPCDLAQ O_anatinus_ENSOANP00000006435 --EECPGNPSHH--ALERSSETHSDYLLRTRQVVDLSDT--VFPKNPA-MCSEEARLETFQ-NWP-----------------------------------------EYT--LLSPGQLAR D_melanogaster_FBpp0086432 ------------------------PRSQESDNEGNSVVDSPESCSCPD-LLLEANRLVTFK-DWP-----------------------------------------NP---NITPQALAK G_gorilla_ENSGGOP00000008442 --ENYLGSRNHF--ALDRPSETHADYLLRTGQVVDISDT--IYPRNPA-MYSEEARLKSFQ-NWP-----------------------------------------DYA--HLTPRELAS A_carolinensis_ENSACAP00000011315 --ENGSASTSQQQPSLDESSDLDADYLLRTGQVVDLSGS--LYPRNPA-MCSEEARLRTFH-NWP-----------------------------------------PYA--PVTPQDLAH A_aegypti_AAEL006633-PA -----------------------------------------------E-LKREEHRLATYV-NWP-----------------------------------------IS---HISPSSLAK T_nigroviridis_ENSTNIP00000018867 ----QLIDASLANNSAYNEE-----------AVVDES----IYPVAPH-MKSEKSRLQTFS-SWP-----------------------------------------SAV--PVRPQDLAQ D_rerio_ENSDARP00000013586 ---------NSIQSPDYDEEAENREFLLRTGEVVDES----MYPVVPH-MKSEEARLSTFN-NWP-----------------------------------------ADS--PVRPEDLAE G_aculeatus_ENSGACP00000024474 ----LSCENRLTNGFSYNEEEEDLEYRLRRGEVVDES----TYPMAPH-MKSEEARLQTLS-TWP-----------------------------------------SSS--PVRPRDLAQ O_latipes_ENSORLP00000012199 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000002256 ---GQG---------------------------------------------------------------------------------------------------------GIYSETLA- G_gallus_ENSGALP00000009239 -----------------------------------------CHLFNYS-MRDEARRLRTFS-QWP-----------------------------------------RSS--PVSAWDLAK T_guttata_ENSTGUP00000007779 -----------------------------------------RRLFEAS-MRSVARRLRTFQ-QWP-----------------------------------------RTA--PVSARDLVE M_domestica_ENSMODP00000021022 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000000487 ---------------------------------------------SIE-LFKEENRRETFK-TWS-----------------------------------------AAF-NDEFVKELAR H_sapiens_ENSP00000321377 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000019640 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000000510 ---------------------------------------------SIE-LFKEENRRETFK-TWS-----------------------------------------AAF-NDEFVKELAR C_intestinalis_ENSCINP00000021651 -------------TNISTPNHQDMNHFVNTNPTEVVFET--MLLKRLT-HKSIKLNIRTFD-YWP-----------------------------------------HQL-REVNTAALAK G_gorilla_ENSGGOP00000007398 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000000466 -------------------------------------------------QNLPSLQNASFVQSIP-----------------------------------------NQDQTTLSAGELLK X_tropicalis_ENSXETP00000016315 ---------------------IRHSYFMEEGVGPGFLDTNILGKE--GDMSDEYSRIQSYQ-AVK-----------------------------------------EHF-PNQTPIKLAW X_tropicalis_ENSXETP00000016312 ----------KENQSKVCAGPIKEG---ESGTTVPLSSSSNLEKKPCGYMSDEYSRLESYR-GHGQHFNYWN----------------------------------QQRLAKQTSDELAW M_musculus_ENSMUSP00000112867 -----------------------------KYDIRVKSPEKML-RGGKARYHEEEARLESFE-DWP-----------------------------------------FYA-HGTSPRALSA G_gorilla_ENSGGOP00000008152 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000058611 -----------------------------KYDIRVKRPEKML-RGGKARYHEEEARLESFE-DWP-----------------------------------------FYA-HGTSPRVLSA C_intestinalis_ENSCINP00000020067 --------------------------------MAEIDRQDITGLASPSLTQHKEAKTQILP----------------------------------------------------------- M_musculus_ENSMUSP00000022142 -----------------------------KYDIRVKSPEKML-RGGKARYHEEEARLESFE-DWP-----------------------------------------FYA-HGTSPRVLSA X_tropicalis_ENSXETP00000057704 ----------------------------KDCHYEPGLGSNILMEKPLGDLSDERRRLETFR-GHSGLFPYNRVKFLAIQSPNILGKKSHYDMTNMYSRADTYRGHHKHFLPYMKEWDLAQ H_sapiens_ENSP00000217169 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000023641 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000034890 ----------TQDQSQVCPMPIKEG---ESGIPARYSGSHNPGEKPLGDMNDEYSRLETYR-GHS-----------------------------------------QYF-PMANQRRLAQ B_taurus_ENSBTAP00000004317 -----------------------------KYDVRVQKPENTLRRDDKARYQEEKARLESFK-NWP-----------------------------------------FYA-QGTSPRELSA M_mulatta_ENSMMUP00000012096 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000048273 -----------------------------KYDIRVKNLKSRL-RGGKMRYQEEEARLASFR-NWP-----------------------------------------FYV-QGISPCVLSE M_musculus_ENSMUSP00000113890 -----------------------------KYDIRVKSPEKML-RGDKARYHEEEARLESFE-DWP-----------------------------------------FYA-HGTSPRVLSA R_norvegicus_ENSRNOP00000024483 -----------------------------KYDIRVKNPETLP-RGGRARYHEEEARLESFE-DWP-----------------------------------------FYA-HGTSPRVLSA H_sapiens_ENSP00000194097 -----------------------------KYDIRVKNLKSRL-RGGKMRYQEEEARLASFR-NWP-----------------------------------------FYV-QGISPCVLSE C_intestinalis_ENSCINP00000010449 ---------------------------------GLSRPNENATFRSLPTRRPAHSNVHSSS-SLP------------------------------------------RQPTTITINQPRI M_musculus_ENSMUSP00000104503 ---------------------------------------------------------------------------------------------------------------MFSPADLFR P_pygmaeus_ENSPPYP00000017359 -----------------------------KYDIRVKNLKSRL-RGGKMRYQEEEARLASFK-NWP-----------------------------------------FYV-QGIPPCVLSE P_pygmaeus_ENSPPYP00000012543 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017749 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0075254 ------------------------FDQVDNNTNATQLFKNNINKTRMNDLNREETRLKTFT-DWP-----------------------------------------LD---WLDKRQLAQ A_aegypti_AAEL009074-PA ----------------------------DNKVKEDNAYGHTATSVPIS-YHTEVARLESFR-GWM-----------------------------------------VS---FISKTELAR C_familiaris_ENSCAFP00000018803 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000005440 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000002314 -----------------------------KYEVRVRKPPGTL-RGDAARYREEEARLKSFK-DWP-----------------------------------------FYA-QATAPRELSA C_intestinalis_ENSCINP00000011648 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP007293-PA --------------------------------REIAEYRVTHDTPEEC-LNYEVNRLRTFP-LWT-----------------------------------------VP---YIYPEELAR A_gambiae_AGAP007291-PA --------------------------------REIAEYRVTHIVPEEC-LNYEINRLRTYDLLWT-----------------------------------------VP---YIYPEELAR A_gambiae_AGAP007292-PA ----------------------------MESHDNTERQERTGLCNELN-YNQEINRLRTYFPLWT-----------------------------------------VP---YIYPEELAR O_cuniculus_ENSOCUP00000002871 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000002312 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000008701 KYLPQSVNDVSMVPNTSENNEVSDEECPQIYLAQVYSAEHREFLHTLN-LNKESGRLKSFR-NWP-----------------------------------------DN---SLDKTLLAK A_gambiae_AGAP011326-PA -------------------------------------------------MSSASGS-------------------------------------------------------EVQPA---- O_cuniculus_ENSOCUP00000000543 -------------------------------------------------VSRELKGAKKIHLGED-----------------------------------------LKSILSEAPGKCVP P_pygmaeus_ENSPPYP00000002056 -------------------------------------------------VSQELKGAKKVHLGED-----------------------------------------LKSILSEAPGKCVP H_sapiens_ENSP00000264198 -------------------------------------------------VSQELKGAKKVHLGED-----------------------------------------LKSILSEAPGKCVP M_mulatta_ENSMMUP00000009065 -------------------------------------------------VSQELKGAKKVHLGED-----------------------------------------LKSILSEAPGKCVP E_caballus_ENSECAP00000013139 -------------------------------------------------VAQELKGARRIHLGED-----------------------------------------LKSILSEAPGKCVP P_troglodytes_ENSPTRP00000000497 -------------------------------------------------VSQELKGAKKVHLGED-----------------------------------------LKSILSEAPGKCVP 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000065554 AGLYYLGQGDRV----------ACFSCGGQLG--SWEPGDRAVSEHQRHYPNCRFVRGDRA----------------------------------------------------------- T_rubripes_ENSTRUP00000043752 AGFYYLSQGDRV----------ACFSCGGQLS--NWEPGDRAMSEHQRHYPNCRFVRGDRA----------------------------------------------------------- T_nigroviridis_ENSTNIP00000012883 AGFYYLSQGDRV----------ACFSCGGQLN--NWEPGDRAMSEHQRHYPNCRFVRGDRA----------------------------------------------------------- O_latipes_ENSORLP00000006992 AGFYYLGQNDRV----------ACFSCGGQLS--NWEPGDRAVSEHQRHYPNCRFVRGDRA----------------------------------------------------------- G_aculeatus_ENSGACP00000027283 AGFYYLGQGDRV----------ACFSCGGQLS--NWEPGDRAVSEHQRHYPNCRFLSSGAA----------------------------------------------------------- T_guttata_ENSTGUP00000013125 AGFYYLGTADKV----------ACFTCGGQLY--NWEPKDNAVSEHRRHYPNCPFVENLIR----------------------------------------------------------- O_anatinus_ENSOANP00000016616 AGFYYTGPGDRV----------ACFTCGGKLS--NWEPKDDAMSEHRRHFPGCPFLERQTR----------------------------------------------------------- G_gallus_ENSGALP00000035646 AGLYYLGTADKV----------ACFTCGGQLS--NWEPKDNAMSEHRRHFPNCPFVENLMR----------------------------------------------------------- E_caballus_ENSECAP00000000598 AGFYYIGPGDRV----------ACFACGGTLS--NWEPKDDAMSEHRRHFPNCPFLENSL------------------------------------------------------------ M_mulatta_ENSMMUP00000004536 AGFYYIGPGDRV----------ACFACGGKLS--NWEPKDDAMSEHRRHFPNCPFLENSL------------------------------------------------------------ H_sapiens_ENSP00000227758 AGFYYIGPGDRV----------ACFACGGKLS--NWEPKDDAMSEHRRHFPNCPFLENSL------------------------------------------------------------ P_pygmaeus_ENSPPYP00000004357 AGFYYIGPGDRV----------ACFACGGKLS--NWEPKDDAMSEHRRHFPNCPFLENSL------------------------------------------------------------ P_troglodytes_ENSPTRP00000007251 AGFYYIGPGDRV----------ACFACGGKLS--NWEPKDDAMSEHRRHFPNCPFLENSL------------------------------------------------------------ C_familiaris_ENSCAFP00000022277 AGFYYIGPGDKV----------ACFACGGTLS--NWEPKDDAMSEHRRHFPNCPFLENSL------------------------------------------------------------ E_caballus_ENSECAP00000010270 AGFYYIGPGDRV----------ACFACGGKLS--NWEPKDDAMSEHLRHFPNCPFVENQFE----------------------------------------------------------- M_domestica_ENSMODP00000000728 AGFYYIGPGDMV----------ACFACGGKLS--NWEPKDDAMSEHRRHFPHCPFLESQIQ----------------------------------------------------------- A_carolinensis_ENSACAP00000012475 AGFYYIGPADKV----------ACFVCGGHLG--NWEPKDNAMSEHRRHFPTCPFVE-QTQ----------------------------------------------------------- C_familiaris_ENSCAFP00000022282 AGFYYVGPGDRV----------ACFACGGKLS--NWEPDDDALSEHLRHFPDCPFVEGQLQ----------------------------------------------------------- P_troglodytes_ENSPTRP00000007250 AGFYYIGPGDRV----------ACFACGGKLS--NWEPKDNAMSEHLRHFPKCPFIENQLQ----------------------------------------------------------- M_mulatta_ENSMMUP00000004533 AGFYYVGPGDRV----------ACFACGGKLS--NWEPKDNAMSEHLRHFPKCPFIENQLQ----------------------------------------------------------- H_sapiens_ENSP00000376897 AGFYYIGPGDRV----------ACFACGGKLS--NWEPKDNAMSEHLRHFPKCPFIENQLQ----------------------------------------------------------- M_musculus_ENSMUSP00000091422 AGFYYIGPGDRV----------ACFACGGKLS--NWEPKDDAMSEHRRHFPHCPFLENTS------------------------------------------------------------ P_pygmaeus_ENSPPYP00000004355 AGFYYIGPGDRV----------ACFACGGKLS--NWEPKDNAMSEHLRHFPKCPFIENQLQ----------------------------------------------------------- R_norvegicus_ENSRNOP00000007702 AGFYYTGPGDRV----------ACFACGGKLS--NWDRKDDPLSEHRRHFPSCPFLKDVGQ----------------------------------------------------------- R_norvegicus_ENSRNOP00000014560 AGFYYTGPGDRV----------ACFACGGKLS--NWEPNDDPLSEHRRHFPHCPFLENTS------------------------------------------------------------ X_tropicalis_ENSXETP00000048002 AGFYFVGPGDKV----------ACFTCDGKLN--NWEPNDNAMSEHRRHFPNCPFVKSSTR----------------------------------------------------------- M_musculus_ENSMUSP00000013949 AGFYYIGPGDRV----------ACFACDGKLS--NWERKDDAMSEHQRHFPSCPFLKDLGQ----------------------------------------------------------- B_taurus_ENSBTAP00000034604 AGFYYIGPGDRV----------ACFACGGTLS--NWEPKDDAMSEHLRHFPNCPFLGNQLQ----------------------------------------------------------- O_cuniculus_ENSOCUP00000011948 AGFYYIGPGDRV----------ACFACGGKLS--NWEPKDDAMSEHRRHFPKCPFLENSL------------------------------------------------------------ M_domestica_ENSMODP00000000705 AGFYYIGPGDMV----------ACFACGGKLS--NWEPKDDAMSEHRRHFPHCPFLESQIQ----------------------------------------------------------- O_cuniculus_ENSOCUP00000008710 AGFYYVGPGDRV-