10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000071815 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000040691 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000006831 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000009934 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010095 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022402 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003217 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006879 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010793 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000017288 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000009498 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000003106 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000008706 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000358327 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000005216 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000019797 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013731 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000091238 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000517 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000032189 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000014096 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000001627 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000016420 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000022693 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000311032 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008661 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005556 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000017020 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000031759 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026062 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000022078 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000015808 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000014503 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000011206 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000019984 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000021099 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002508 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000007184 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005560 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000040783 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000014729 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000012376 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011493 ------------------------------------------------------------------------------------MDPHPADFPEPPPQPRITLRSDTVDSSVFHDDDNLF M_domestica_ENSMODP00000005512 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011952-PA ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000013049 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000072390 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000028104 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000029626 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000050929 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000265164 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009832-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000016791 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023055 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000016744 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0071971 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000005811 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000005993 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0084848 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000022652 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL014348-PA ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013268 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000003204 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004278 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000016642 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000021186 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004920-PA ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000007353 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP000830-PA ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000052017 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003444-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000041413 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000019870 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012644 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004921-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011951-PA ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000025743 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011835 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000093958 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000005723 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL012143-PA ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000037892 VEGGRRARVVTESKRNFFLGACPTPFPTEHVELGRLGGSETAMVPGKGGADYILLPFEEMDFNRNLYDIGEQLDSEELASLKFLSLDCIPQRKQEPIKDALMLFQRLQEKRMLEENNLSF C_intestinalis_ENSCINP00000024485 ------------------------------------------------------------EFRLLLHQICEGLTGENVSMMKFLCKDAIPRSRE--LETALDFMEYFEAKGWIQEGDLGF P_pygmaeus_ENSPPYP00000014606 -----------------------------------------------------------MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF O_cuniculus_ENSOCUP00000006164 -------------------------------ALVESGTVGDWVTVPGEGNGYXXXXXXXXXXXXXXXXXXEQLDSELL--LKF-ELDYIPQRKQEPIQDALMLFQRLQEKRMLEENNLAF T_guttata_ENSTGUP00000010625 ------------------------------------------------------------DFRKLLFEVSEALVTEELSALKFLSLDHVPRRKLEAIHEPKAFFEVLQEKDMIGAGNLFF P_troglodytes_ENSPTRP00000021879 MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF H_sapiens_ENSP00000351273 MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF X_tropicalis_ENSXETP00000008971 -----------------------------------------------------------MDFNSMLLSIDDGLGREDIEALKFLCRDVLRKNKLLSVRSGQELFQQLMTEDLINEDNFFL R_norvegicus_ENSRNOP00000016613 -----------------------------------------------------------MDFHSCLYDIAERLGNEELAALKFLCLDHIPQKKQESINDVLVLFQRLQEEGMLEEDNLSF C_intestinalis_ENSCINP00000011503 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000038128 -----------------------------------------------------------MALTQCLYNIGEQLGSDDLAALKFLSRDHIPYRKQEPIKDALMLFQRLQEKRMLEENNLSF C_familiaris_ENSCAFP00000017899 -----------------------------------------------------------MDFSKCLYNIGEQLDSDELASLKFLSLDYIPQKKQEPIKDPLMLFQRLQEKRMLEESNLFF D_melanogaster_FBpp0082755 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000001216 --------------------------------------------------------------------------------------------------SAYQLFLSLCDQDHLSEERPHL M_musculus_ENSMUSP00000027189 -----------------------------------------------------------MDFQSCLYAIAEELGSEDLAALKFLCLDYIPHKKQETIEDAQKLFLRLREKGMLEEGNLSF O_cuniculus_ENSOCUP00000003895 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000000205 ---------------------------------------------------YILLPFEKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF T_guttata_ENSTGUP00000017449 --------------------------------------------------------------------------------------------------------MEERQRRALRRGRARL O_anatinus_ENSOANP00000006351 -----------------------------------------------------------MDFHRLLFSIGEELAADDLEALKFLCLDLIPRKKQENIQDALGLFRLLQEKGMLEEGKLFF H_sapiens_ENSP00000286186 ------------------------------------------MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFF G_gallus_ENSGALP00000013591 -----------------------------------------------------------MEFSQLLFVISEALDRTELASLKFLSLEHVTVRKREDIEEPKAFFQALQEKGMIEVGDLFF C_intestinalis_ENSCINP00000025905 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000030747 --------------------------------------------------------------------------------------------------------MDEADRQLLRRCRVRL R_norvegicus_ENSRNOP00000017972 --------------------------------------------------------------------------------------------------------MEEADRQLLRRCRVRL E_caballus_ENSECAP00000004055 -----------------------------------------------------------MNFNSCLYNIGEQLDSDELASLKFLSLDHIPQRKQEPIQDALMLFQRLQEKRLLEESNLSF G_aculeatus_ENSGACP00000005791 -----------------------------------------------------------MHFQKLLFDIGKALSGEEVKALAFLCTD-ILGRNLSSVESASGLFSRLRDQGFLSAEQPHL O_anatinus_ENSOANP00000015596 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000036247 -----------------------------------------------------------MDFHTFLYGIAEEIDSADLASLKFLCLDQIPLKKQQHIKDALVLFQTLEERGLLEEDNLFF E_caballus_ENSECAP00000021726 ------------------------------------------MTSQGQNLNSSSDDNCTMDFRQKLLFIDSHLGDQDVERLRFLCRDCVSHKKLEKSSSALEIFNHLLAEDLLREEDSFF E_caballus_ENSECAP00000015102 --------------------------------------------------------------------------------------------------------MNEADRQLLRRSRLRL C_intestinalis_ENSCINP00000028692 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000017933 ------------------------------------------MTSQAQSLTFRSDDNCQSSFRGKLLTIDSKLEIQDVEGLKFLCRDFVSHKKLEKSNSASDIFDHLLAEELLSEEDPFF A_carolinensis_ENSACAP00000001629 -------------------------------------------------------------FRQILLAIDENLGKEDVDAMKFLCSDFISTKHLEGVETAQDIFQLLINRNLLSKEDTFI T_rubripes_ENSTRUP00000047737 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000003205 --------------------------------------------------------------------------------------------------------MNEADRLLLRRYRVRL A_gambiae_AGAP004922-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP012945-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014602 ------------------------------------------MKSQGQHWCSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCVGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFF P_pygmaeus_ENSPPYP00000002138 --------------------------------------------------------------------------------------------------------MDEADRRLLWRCRLRL T_nigroviridis_ENSTNIP00000016604 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000037898 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000013506 -----------------------------------------LKSFKPHWISSNMEDDDSLQFRQLLLLIDEGLGAEDVAALKFLCTDLIPFRKLESVQSAMDIFQLLIDEDYLNEEDTFL D_rerio_ENSDARP00000071183 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000075318 ------------------------------------------------------------------------------MADQLLENLRPDLIKGLSERVINGLLDDLQQKKVFGEEEIED G_aculeatus_ENSGACP00000023872 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000002479 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003439-PA ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000016983 ------------------------------------------------------------------------------MSARGKVRSQKTAIHEALCADYSLILNKVFEKGLITPREYRN G_gallus_ENSGALP00000002083 --------------------------------------------------------------------------------------------------------MEEAQRSALRRGRVRL G_gallus_ENSGALP00000013571 ---------------------------------------------------------MSSDFRKLLFDISEALATEELAALKFLSLEHVPVRKQEDTEEPKAFFEVLKEKGMIEVEDLFF C_elegans_C48D1.2 -------------------------------------------------------------------------------------------------------MMRQDRRSLLERNIMMF O_anatinus_ENSOANP00000005531 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000024255 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011949-PA ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000365051 ---------------------------------------------------------------------RGGRPWGGGGSWGLGRAAEARKRTEAAWSLSWLLAMDEADRRLLRRCRLRL M_mulatta_ENSMMUP00000033547 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000063081 ---------------------------------------------------------------------------MSKKESTQRILQHKVFLIDTLSVEASFILQNVQQAKLITQRDYNN M_domestica_ENSMODP00000004412 --------------------------------------------------------------------------------------------------------MEESQRELFQKNRLRL T_nigroviridis_ENSTNIP00000013855 --------------------------------------------------------------------------------------------------------MEERHKKILQRNRINL D_rerio_ENSDARP00000075645 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011950-PA ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000056642 ---------------------------------------------------------------------RGGRPWGGGGSWGLGRAAEARKRTEAAWSLSWLLAMDEADRRLLRRCRLRL 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000071815 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000040691 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000006831 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000009934 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010095 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022402 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003217 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006879 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010793 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000017288 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000009498 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000003106 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000008706 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000358327 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000005216 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000019797 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013731 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000091238 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000517 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000032189 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000014096 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000001627 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000016420 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000022693 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000311032 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008661 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005556 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000017020 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000031759 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026062 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000022078 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000015808 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000014503 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000011206 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000019984 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000021099 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002508 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000007184 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005560 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000040783 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000014729 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000012376 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011493 SMDDAVEQPDSFDAVPPNSYPSPNSSLSTSYSGGDILS--------------------------------------------------------------------------------MA M_domestica_ENSMODP00000005512 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011952-PA ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000013049 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000072390 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000028104 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000029626 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000050929 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000265164 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009832-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000016791 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023055 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000016744 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0071971 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000005811 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000005993 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0084848 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000022652 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL014348-PA ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013268 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000003204 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004278 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000016642 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000021186 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004920-PA ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000007353 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP000830-PA ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000052017 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003444-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000041413 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000019870 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012644 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004921-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011951-PA ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000025743 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011835 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000093958 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000005723 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL012143-PA ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000037892 LKELLFRINRLDLLTTYLNTRKEEMERELQAPGRAQISAY--------------------------------R------------------------------------VMLYQISEEVG C_intestinalis_ENSCINP00000024485 LAEVLYRINRHDLLKLLPGVKNRRDYEENFQAQQNNFTTY--------------------------------R------------------------------------VVCFMLADELT P_pygmaeus_ENSPPYP00000014606 LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQSVPFWWRVDHILIR------------------------------------VMLYQISEEVS O_cuniculus_ENSOCUP00000006164 LKELLFRIHRLDLLSTLLGTSKEEMVTELQIPGRAHISAY--------------------------------X------------------------------------XXXXXXXXXXX T_guttata_ENSTGUP00000010625 LKELLYRIHRIDLLSTPLGCSREEMERELQLPGRAQVSAY--------------------------------R------------------------------------QLLYGIAEDLT P_troglodytes_ENSPTRP00000021879 LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY--------------------------------R------------------------------------VMLYQISEEVS H_sapiens_ENSP00000351273 LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY--------------------------------R------------------------------------VMLYQISEEVS X_tropicalis_ENSXETP00000008971 LKELLYIINHHSLL-RNLGTNKEKVQKAL--PRQGRISPY--------------------------------R------------------------------------QMLYQLSENIA R_norvegicus_ENSRNOP00000016613 LKELLFHISRRDLLSRVLKSSPEEMVRELQVLGKAQVSAY--------------------------------R------------------------------------VMLFKLSEDMD C_intestinalis_ENSCINP00000011503 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000038128 LKELLFRVNRLDLLLNYLYTSEEEMKRELQIPGRAQISAY--------------------------------R------------------------------------ILLFQISEDVN C_familiaris_ENSCAFP00000017899 LKELLFRINRLDLLMTYLDTSKEDMQQELQIPGRAQISAY--------------------------------R------------------------------------VMLFQISEDVS D_melanogaster_FBpp0082755 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000001216 LSELLSIIQRTRLLRDLDLRSS---------ATSNLISAY--------------------------------R------------------------------------KLLYSLSEDLT M_musculus_ENSMUSP00000027189 LKELLFHISRWDLLVNFLDCNREEMVRELRDPDNAQISPY--------------------------------R------------------------------------VMLFKLSEEVS O_cuniculus_ENSOCUP00000003895 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000000205 LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY--------------------------------R------------------------------------VMLYQISEEVS T_guttata_ENSTGUP00000017449 VAALRVEPLWEPLEQRGLFT-------------------R--------------------------------P------------------------------------MLEELQS--AG O_anatinus_ENSOANP00000006351 LKELLFRIHRIDLLTSHLRTSQEDVARELEEPGRAQVSAYS-------------------------------R------------------------------------VLLFTLSDNVT H_sapiens_ENSP00000286186 LAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLF--------------------------------R------------------------------------NLLYELSEGID G_gallus_ENSGALP00000013591 LKELLYRINRIDLLASYLGSSREEMERELQVPGRARVSPF--------------------------------R------------------------------------YLLFQLSENIT C_intestinalis_ENSCINP00000025905 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000030747 VSELQVAELWDALLSRELFT-------------------R--------------------------------D------------------------------------MIEDIQQAGSG R_norvegicus_ENSRNOP00000017972 VRELQVAELWDALLSRELFT-------------------R--------------------------------D------------------------------------MIEDIQRAGSG E_caballus_ENSECAP00000004055 LKELLFRINRLDLLTTELDTSKEEMERELQSPGRAQISAY--------------------------------R------------------------------------VMLFQISEDVN G_aculeatus_ENSGACP00000005791 LTELLIIIQRVRLT----------RDVDLPAEPSSLISPY--------------------------------R------------------------------------KMLYNLSEELT O_anatinus_ENSOANP00000015596 ----------------------------------------------------------------------------------------------------------------------AG M_domestica_ENSMODP00000036247 LKELLFRINRIDLLNEPLNTKGPEMERELQVPNKARISPY--------------------------------RLHLHTTIWPFRDNWTCRITLSVSFTSRTKQLLSVMVILLFNLSEGVG E_caballus_ENSECAP00000021726 LAELLYIIKQKSLL-CHLCYTKEQVESLL--PARRRVSLF--------------------------------R------------------------------------NLLYELSEGMD E_caballus_ENSECAP00000015102 VRELQVDSLWDALLTRELFT-------------------P--------------------------------D------------------------------------MIEDIQR--SG C_intestinalis_ENSCINP00000028692 ----------------------------------------------------------------------------------------------------------------------MS C_familiaris_ENSCAFP00000017933 LAELLYIIKQNSLL-RYLNQSKEQVESLL--PTRRRVSLF--------------------------------R------------------------------------NLLYELSESIG A_carolinensis_ENSACAP00000001629 VAELLYRIKCHFLL-QKIGYTQQKVEHNL--FHIRNVSEY--------------------------------R------------------------------------QMLYEISEGFT T_rubripes_ENSTRUP00000047737 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000003205 VGELQVASLWDALLSRELFT-------------------P--------------------------------D------------------------------------MIEDIQRAGSG A_gambiae_AGAP004922-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP012945-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014602 LAELLYIIRQKKLL-QHLSYTKEEVEGLL--PTRQRVSLF--------------------------------R------------------------------------NLLYELSEGID P_pygmaeus_ENSPPYP00000002138 VEELQVDQLWDALLSRELFR-------------------P--------------------------------H------------------------------------MIEDIQRAGSG T_nigroviridis_ENSTNIP00000016604 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000037898 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000013506 LAELLYRIKYHSLL-SKLGYTKEKVQECL--HEKGKVSPY--------------------------------R------------------------------------QMLYELSENIT D_rerio_ENSDARP00000071183 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000075318 IQHR------------------------------------------------------------------------------------------------------------------MK G_aculeatus_ENSGACP00000023872 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000002479 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003439-PA ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000016983 LKSI-----------------------------------------------------------------------------------------------------------------NKE G_gallus_ENSGALP00000002083 VEGLRPEVLWGPLQARGVFT-------------------S--------------------------------A------------------------------------MVEDMQS--TG G_gallus_ENSGALP00000013571 LKELLYRINRIDLLASHLGSSREEMERELQVPGKAKVSAY--------------------------------R------------------------------------QLLYGIAEDLT C_elegans_C48D1.2 SSHLKVDEILEVLIAKQVLNSDNGDMINS-----------------------------------------------------------------------------------------CG O_anatinus_ENSOANP00000005531 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000024255 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011949-PA ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000365051 VEELQVDQLWDALLSRELFR-------------------P--------------------------------H------------------------------------MIEDIQRAGSG M_mulatta_ENSMMUP00000033547 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000063081 LSD-------------------------------------------------------------------------------------------------------------------VS M_domestica_ENSMODP00000004412 VCELQVEPLWDLMLDRELFT-------------------R--------------------------------D------------------------------------MIEDIQR--AG T_nigroviridis_ENSTNIP00000013855 VSELEPLNLYDGLIEKGVFT-------------------H--------------------------------D------------------------------------MIDEIKC--SG D_rerio_ENSDARP00000075645 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011950-PA ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000056642 VEELQVDQLWDALLSRELFR-------------------P--------------------------------H------------------------------------MIEDIQRAGSG 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000071815 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000040691 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000006831 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000009934 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010095 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022402 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003217 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006879 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010793 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000017288 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000009498 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000003106 ---------------------------------------------------------------------------------------MDCVGWPPGRRWHLEKNTSCSGSSGICASYVTQ B_taurus_ENSBTAP00000008706 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000358327 ---------------------------------------------------------------------------------------MDCVGWPPGRKWHLEKNTSCGGSSGICASYVTQ P_troglodytes_ENSPTRP00000005216 ---------------------------------------------------------------------------------------MDCVGWPPGRKWHLEKNTSCGGSSGICASYVTQ E_caballus_ENSECAP00000019797 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013731 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000091238 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000517 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000032189 ----------------------------------------------------------------------------------------------------------MGEQRNTSSKELAA R_norvegicus_ENSRNOP00000014096 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000001627 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000016420 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000022693 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000311032 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008661 -------------------------------------------------------------------------------------------------------------------QVNGA M_domestica_ENSMODP00000005556 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000017020 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000031759 ------------------------------------------------------------------------------------------------------------------SMQMAG M_musculus_ENSMUSP00000026062 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000022078 ---------------------------------------------------------------------------------------------------------------------MAG M_mulatta_ENSMMUP00000015808 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000014503 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000011206 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000019984 -------------------------------------------------------------------------------MDKEALTSENEVSGDDQENYGKGDVTDAKPDPKAMCRVDKE B_taurus_ENSBTAP00000021099 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002508 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000007184 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005560 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000040783 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000014729 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000012376 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011493 SPPLPVTRITERTQTAGEVIRTYNPSPEKRDHEVSYDELLEED------------------------------------------------------------------MKFSAEGVSDS M_domestica_ENSMODP00000005512 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011952-PA ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000013049 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000072390 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000028104 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000029626 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000050929 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000265164 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009832-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000016791 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023055 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000016744 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0071971 --------------------------------------------------------------------------------------------------------MTDECVTRNYGVGIRS O_anatinus_ENSOANP00000005811 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000005993 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0084848 -------------------------------------------------------------------------------------------------------MDATNNGESADQVGIRV T_rubripes_ENSTRUP00000022652 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL014348-PA ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013268 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000003204 ----------------------------------------------------------------------------------------------------------------MSLKSAAD T_guttata_ENSTGUP00000004278 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000016642 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000021186 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004920-PA ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000007353 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP000830-PA ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000052017 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003444-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000041413 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000019870 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012644 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004921-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011951-PA ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000025743 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011835 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000093958 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000005723 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL012143-PA ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000037892 RSELRSFKFLLQ-EEISKCKLDDDMNLLDIFVEMEKRVILGEGKLDILKRVCAQVNKSLLKIINDYEEFSRE------------------------------------------RTRSLE C_intestinalis_ENSCINP00000024485 EGDLKILKRLCA-GKMSKANVRRSVDVLSWLTCMEEEDLLSEGDLDFIMSILQHLDNQKPYKLFQ--------------------------------------RVRMNDNTVTLPKNQQK P_pygmaeus_ENSPPYP00000014606 RSELRCFKFLLQ-EEISKCKLDDDMNLL