>H_sapiens_ENSP00000216797 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MF--QAAERPQE---WAME-GPRDGLKKER-----LLDDR----- -----HDSGLDSMKDEE------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------YE- -QMVKELQEIRLE--------PQEVPRG-----------S--EPWKQQLTEDGDSFLHLA IIHEEKALTMEVIRQ---VKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPE LRDFRGNTPLHLACE-QG--CLASVGVLTQSCTT-------------------------- ---------------PHLHSILKATNYN------------------------------GH TCLHLASIHGY---------------------------LGIVELLVSL-GAD--VNAQEP CNGRTALHLAVDLQNPDLVSLLL-KCGA--DVNRVTYQGYSPYQLTWGRP----STRIQQ QLGQLTLE---------------------------------------------------- -----NLQMLP-ESEDEE----SYDTES-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------EFTEFTE------DELPYDD-CVFGGQRLTL------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_mulatta_ENSMMUP00000026809 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MF--QAAERPQE---WAME-GPRDGLKKER-----LLDDR----- -----HDSGLDSMKDEE------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------YE- -QMVKELQEIRLE--------PQEVPRG-----------A--EPWKQQLTEDGDSFLHLA IIHEEKALTMEVIRQ---VKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPE LRDFRGNTPLHLACE-QG--CLASVGVLTQSCTT-------------------------- ---------------PHLHSILKATNYN------------------------------GH TCLHLASIHGY---------------------------LGIVELLVSL-GAD--VNAQEP CNGRTALHLAVDLQNPDLVSLLL-KCGA--DVNRVTYQGYSPYQLTWGRP----STRIQQ QLGQLTLE---------------------------------------------------- -----NLQMLP-ESEDEE----SYDTES-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------EFTEFTE------DELPYDD-CVFGGQRLTL------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_troglodytes_ENSPTRP00000010634 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MF--QAAERPQE---WAME-GPRDGLKKER-----LLDDR----- -----HDSGLDSMKDEE------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------YE- -QMVKELQEIRLE--------PQEVPRG-----------A--EPWKQQLTEDGDSFLHLA IIHEEKALTMEVIRQ---VKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPE LRDFRGNTPLHLACE-QG--CLASVGVLTQSCTT-------------------------- ---------------PHLHSILKATNYN------------------------------GH TCLHLASIHGY---------------------------LGIVELLVSL-GAD--VNAQEP CNGRTALHLAVDLQNPDLVSLLL-KCGA--DVNRVTYQGYSPYQLTWGRP----STRIQQ QLGQLTLE---------------------------------------------------- -----NLQMLP-ESEDEE----SYDTES-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------EFTEFTE------DELPYDD-CVFGGQRLTL------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_gorilla_ENSGGOP00000009178 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MF--QAAERPQE---WAME-GPRDGLKKER-----LLDDR----- -----HDSGLDSMKDEE------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------YE- -QMVKELQEIRLE--------PQEVPRG-----------A--EPWKQQLTEDGDSFLHLA IIHEEKALTMEVIRQ---VKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPE LRDFRGNTPLHLACE-QG--CLASVGVLTQSCTT-------------------------- ---------------PHLHSILKATNYN------------------------------GH TCLHLASIHGY---------------------------LGXVELLVSL-GAD--VNAQEP CNGRTALHLAVDLQNPDLVSLLL-KCGA--DVNRVTYQGYSPYQLTWGRP----STRIQQ QLGQLTLE---------------------------------------------------- -----NLQMLP-ESEDEE----SYDTES-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------EFTEFTE------DELPYDD-CVFGGQRLTL------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_pygmaeus_ENSPPYP00000006526 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MF--QAAERPQE---WAME-GPRDGLKKER-----LLDDR----- -----HDSGLDSMKDEE------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------YE- -QMVKELQEIRLE--------PQEVPRG-----------A--EPWKQQLTEDGDSFLHLA IIHEEKALTMEVIRQ---VKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPE LRDFRGNTPLHLACE-QG--CLASVGVLTQSCTT-------------------------- ---------------QHLHSILKATNYN------------------------------GH TCLHLASIHGY---------------------------LGIVELLVSL-GAD--VNAQEP CNGRTALHLAVDLQNPDLVSLLL-KCGA--DVNRVTYQGYSPYQLTWGRP----STRIQQ QLGQLTLE---------------------------------------------------- -----NLQMLP-ESEDEE----SYDTES-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------EFTEFTE------DELPYDD-CVFGGQRLML------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >B_taurus_ENSBTAP00000022183 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MF--QPAEPGQD---WAME-GPRDALKKER-----LLDDR----- -----HDSGLDSMKDEE------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------YE- -QMVKELREIRLE--------PQEAPRG-----------A--EPWKQQLTEDGDSFLHLA IIHEEKALTMEVVRQ---VKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLEAGCDPE LRDFRGNTPLHLACE-QG--CLASVGVLTQPRGT-------------------------- ---------------QHLHSILQATNYN------------------------------GH TCLHLASIHGY---------------------------LGIVELLVSL-GAD--VNAQEP CNGRTALHLAVDLQNPDLVSLLL-KCGA--DVNRVTYQGYSPYQLTWGRP----STRIQQ QLGQLTLE---------------------------------------------------- -----NLQTLP-ESEDEE----SYDTES-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EFTE------DELPYDD-CVLGGQRLTL------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_familiaris_ENSCAFP00000019772 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ML--QQAEHAQD---WAME-GPRDALKKER-----LLDDR----- -----HDSGLDSMKDEE------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------YE- -QLVKELREIRLE--------PQEAPRG-----------A--EPWKQQLTEDGDSFLHLA IIHEEKALTMEVVRQ---VKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLEAGCDPE LRDFRGNTPLHLACE-QG--CLASVGVLTQTCRT-------------------------- ---------------QHLYSILQATNYN------------------------------GH TCLHLASIHGY---------------------------LGIVELLVSL-GAD--VNAQEP CNGRTALHLAVDLQNSDLVSLLL-KCGA--DVNRVTYQGYSPYQLTWGRP----STRIQQ QLGQLTLE---------------------------------------------------- -----NLQMLP-ESEDEE----SYDTES-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EFTE------DELPYDD-CVLGGQRLTL------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_musculus_ENSMUSP00000021413 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MF--QPAGHGQD---WAME-GPRDGLKKER-----LVDDR----- -----HDSGLDSMKDEE------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------YE- -QMVKELREIRLQ--------PQEAPLA-----------A--EPWKQQLTEDGDSFLHLA IIHEEKPLTMEVIGQ---VKGDLAFLNFQNNLQQTPLHLAVITNQPGIAEALLKAGCDPE LRDFRGNTPLHLACE-QG--CLASVAVLTQTCTP-------------------------- ---------------QHLHSVLQATNYN------------------------------GH TCLHLASIHGY---------------------------LAIVEHLVTL-GAD--VNAQEP CNGRTALHLAVDLQNPDLVSLLL-KCGA--DVNRVTYQGYSPYQLTWGRP----STRIQQ QLGQLTLE---------------------------------------------------- -----NLQMLP-ESEDEE----SYDTES-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EFTE------DELPYDD-CVFGGQRLTL------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >R_norvegicus_ENSRNOP00000009894 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MF--QPAGHGQD---WAME-GPRDGLKKER-----LVDDR----- -----HDSGLDSMKDED------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------YE- -QMVKELREIRLQ--------PQEAPLA-----------A--EPWKQQLTEDGDSFLHLA IIHEEKTLTMEVIGQ---VKGDLAFLNFQNNLQQTPLHLAVITNQPGIAEALLKAGCDPE LRDFRGNTPLHLACE-QG--CLASVAVLTQTCTP-------------------------- ---------------QHLHSVLQATNYN------------------------------GH TCLHLASIHGY---------------------------LGIVEHLVTL-GAD--VNAQEP CNGRTALHLAVDLQNPDLVSLLL-KCGA--DVNRVTYQGYSPYQLTWGRP----STRIQQ QLGQLTLE---------------------------------------------------- -----NLQTLP-ESEDEE----SYDTES-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EFTE------DELPYDD-CVFGGQRLTL------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_domestica_ENSMODP00000016013 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RL--PQEENPQE---KDME-SLRDGLKKER-----LLDDR----- -----HDSGLDSMKDED------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------YE- -LMVKELKEIRIQ--------PQEAQPG---------PPQ--EPWKQQVTEDGDSFLHLA IIHEEKTLTLEVIRQ---VAGDLTFLNSQNSLQQTPLHLAVITKQPEIAETLLKAGCDPE LRDFQGNTPLHLACE-QG--CLASVGVLTQYCQT-------------------------- ---------------QDLFSVLQSTNYN------------------------------GH TCLHLASIHGY---------------------------LAIVEHLVSL-GAD--INAQEP CNGRTALHLAVDLQNPELVSLLL-KCGA--DVNKVTYQGYSPYQLTWGRE----NTTIQK QLGQLTME---------------------------------------------------- -----NLQMLP-ESEDEE----SCDTES-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EFTE------DELLYDD-CVIGGQRLTL------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_anatinus_ENSOANP00000027279 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------SFSAEPRPRQGQ---RPRD-GGPDGPKKDRA----LGEDR----- -----HDSGLDSMKDED------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------YE- -LMVQELSAIRLQ--------PQAQARSRPQEAMAPPPPA--EPWRHQVTEDGDSFLHLA VIHEEKALALEVIRR---VKGDLAFLDLQNSLQQTPLHLAVITSQPEIAETLLKAGCDPE LRDFRGNTALHLACE-QG--CLAAVGVLTQYCQT-------------------------- ---------------QHLHAVLQASNYN------------------------------GH TCLHLASIHGY---------------------------LAIVERLVSL-GAD--VNAQEP CNGRTALHLAVDLQNPDLVSLLL-KCGA--DVNRVTYQGYSPYQLTWGRE----STSIQQ QLGQLTMS---------------------------------------------------- -----NLQLLP-ESEDEE----SCDTES-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EFTE------DELLYDD-CVIGGQRLAL------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >E_caballus_ENSECAP00000020980 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------FLHLA IIHEEKALTMEVVRQ---VKGDLAFLNFQNNLQQTPLHLAVITNQPEIAKALLEAGCDPE LRDFRGNTPLHLACE-QG--CLASVGVLTQSYGT-------------------------- ---------------PHLHSILQATNYN------------------------------GH TCLHLASIHGY---------------------------LGIVELLVSL-GAD--VNAQEP CNGRTALHLAVDLQNPDLVSLLL-KCGA--DVNRVTYQGYSPYQLTWGRP----STRIQQ QLGQLTLE---------------------------------------------------- -----NLQMLP-ESEDEE----SYDTES-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EFTE------DELPYDD-CVLGGQRLTL------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_guttata_ENSTGUP00000012344 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MI---AARRAAE---PPAM-DGYEQPKKERQGA-FPLDDR----- -----HDSGLDSMKEEE------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------YR- -QLVKELEDIRLQ--------PREPP-----------------AWAQQLTEDGDTFLHLA IIHEEKALSLEVIQQ---AAGDRAFLNFQNNLSQTPLHLAVITDQSEIAEHLLKAGCDLE IRDFRGNTPLHIACQ-QG--SLRSVSVLTQYCQA-------------------------- ---------------HHLLAVLQAANYN------------------------------GH TCLHLASIQGY---------------------------LAIVEYLLSL-GAD--VNAQEP CNGRTALHLAVDLQNSELVSLLV-KHGA--DVNKVTYQGYSPYQLTWGRD----NSSIQE QLKQLTTA---------------------------------------------------- -----DLQMLP-ESEDEE----SSESEP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EFTE------DELIYDD-CLIGGRQLTF------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_carolinensis_ENSACAP00000001779 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MEAPKKERQ----LDSDR----- -----HDSGLDSMKDEE------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------YE- -DLVRELEGIRLQ--------PVLPDVA---------APQ--TAWKQQVTEDGDTFLHLA IIHEEKPLSLEIIRQ---AERDAAFLNFQNNLNQTPLHLAVITDQPEIAETLLKAGCDPE IRDFRGNTPLHIACE-RG--SLSSVGVLTQYCQ--------------------------- ---------------KQVCSLLQSSNYN------------------------------GH TCLHLASIQGY---------------------------LAIVEYLLSL-GAD--VNAQEP CNGRTALHLAVDLQNQDLVTLLL-NHGA--DVNRVTYQGYSPYQLTWGRS----NSSIQE KLKQFTTM---------------------------------------------------- -----DLQMLP-ESEDEE----SCESDS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EFTE------DELLYDD-CVIGGRHVPC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_gallus_ENSGALP00000016343 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ML---SAQRPAE---PPAV-EGCEPPRKERQGGLLPPDDR----- -----HDSGLDSMKEEE------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------YR- -QLVRELEDIRLQ--------PREPPAR-----------P--HAWVQQLTEDGDTFLHLA IIHEEKALSLEVIRQ---AAGDAAFLNFQNNLSQTPLHLAVITDQAEIAEHLLKAGCDLD VRDFRGNTPLHIACQ-QG--SLRSVSVLTQHCQP-------------------------- ---------------HHLLAVLQATNYN------------------------------GH TCLHLASIQGY---------------------------LAVVEYLLSL-GAD--VNAQEP CNGRTALHLAVDLQNSDLVSLLV-KHGA--DVNKVTYQGYSPYQLTWGRD----NASIQE QLKLLTTA---------------------------------------------------- -----DLQILP-ESEDEE----SSESEP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EFTE------DELMYDD-CCIGGRQLTF------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_cuniculus_ENSOCUP00000013437 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MF--QPAEHAQD---WAME-GPRDALKKER-----LLDDR----- -----HDSGLDSMKDEE------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------YE- -QMVKELREIRLE--------PQEAPRA-----------A--EPWRQQLTEDGDSXXXXX XXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXE-QG--CLAREAVLKQTCTA-------------------------- ---------------QHLHSILQAINYN------------------------------GH TCLHLASIHGY---------------------------LGIVELLVSW-GAD--VNAQEP CNGRTALHLAVDLQNPDLVSLLL-KCGA--DVNRVTYQGYSPYQLTWGRP----STRIQQ QLGQLTLE---------------------------------------------------- -----NLQRLP-ESEDEE----SCDTES-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------T-TE------DELPYDD-CVFGGQRLTL------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >X_tropicalis_ENSXETP00000038920 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MSVPFHDYQGNM---ME---GEARDLRKDKL----LQDDR----- -----IDSGLDSLKEEE------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------YT- -AIITDLSNMRMEGP------PDTSNYE-----------P--EPWKKEVNEDGDTFLHLA IIHEEKTLVKEAIQR---SYRDHFYLNKQNNLHQTALHLAVITEQQDISQSLLQAGCDPE IQDFCGNTALHIACK-QG--SLRGVGVIFQYCE--------------------------- ---------------KQLPALLQSVNYD------------------------------GH TCLHLASIHGY---------------------------LAIVENLINK-GAD--INAQEP CNGRTVLHMAVDLQNYDLMKLLL-KHGA--DVNRVTYQGYSPCQLTWGRN----NMLIQQ QLVEVTHK---------------------------------------------------- -----NLQYLP-ESEEED----SSDSEY-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EYND------DELMYDD-CIIGGRPLH-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_nigroviridis_ENSTNIP00000012589 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MDAHRVSTHHNQ---MDYNSLDSMEAKHGKMLP--CQEDR----- -----FDSGLDSMKEE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -DLANHFEEMSVSE-------GKDLPQE-----------Y--EAWRAAVTDDGDTLLHLA IIHEATDHAHQMIRL---S-HHHPFLNVQNHQRQTALHLAVITRQPQLVEKLLKAGADPR LVDNSGNTALHIACK-RG--SLASFGVITQNCR--------------------------- ---------------RHLTTILSSTNYS------------------------------GH NCLHLASINGY---------------------------ISLVESLVRL-GAD--INAQEQ CSGRTSLHLAVDLQNPPLVRCLL-SLGA--NVNCFNYGGFTPYHLTYGRQ----SEEIRC ELYEKTAH---------------------------------------------------- -----ELRELP-DSESDE----SDMEEA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------DTPE------DE-LYDD-IKFWK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_rubripes_ENSTRUP00000011822 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HRVSSHHNQ---MDYNNHDSMGPKHGKMLP--SQEDR----- -----FDSGLDSLKEE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -ELVNNFEDMSVSN-------VEVLPEE-----------Y--ESWRAVVTDDGDTLLHLA IIHEATDHAHQMIQS---S-RHHPFLNVQNHQRQTALHLAVITDQPQLVDKLLKAGADPR LVDNSGNTALHIACK-RG--SLACFGVITQNCS--------------------------- ---------------RHLTSLLSFPNYS------------------------------GH NCLHLASINGY---------------------------ISLVESLVRL-GAD--INAQEQ CGGRTSLHLAVDLQNPSLVRCLL-GLGA--NVNCFNYGGFTPYHLTYGRQ----SEEIRC ELYEKTAQ---------------------------------------------------- -----ELRELP-DSESDE----SDMDDL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------DTSE------DEQMYDD-IKFGNKSPLY------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >D_rerio_ENSDARP00000007861 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MDLHRAA-MLNF---VDCN-VDEMDTKNRKTQQ---CEDR----- -----VDSGVDSLKEEE------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------YET REISEEMEKLTI---------ASLKETI-----------C--EPWAKVVTEDGDTYLHLA IIHEAEDYAVQIIKQ---C-QNDPYLNRQNNQRQTALHLAVVTEQPQMVERLLKAGCDPQ LVDQSGNTALHLACK-QG--SLACFSVLTQIQT--------------------------- ---------------QHLRSILTFPNYS------------------------------GH TCLHIAAINNY---------------------------LSMVESLVQL-GAD--VDAKEQ CSGRTSLHLAVDLQNLDLVHTLI-ALGA--DANSLTYGGYTAYHLTFGRH----NSEIQR QLYSRTAL---------------------------------------------------- -----KFTVMP-ESESEE----SEDELM-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------SE------DDCIYDD-IRLCGR----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >D_rerio_ENSDARP00000015303 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MELYRGT-TANQ---TDYN-DDGRGPKSGKLLS--NTDER----- -----LDSGLDSLKEDN------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---LPSLEECRIT---------DFVGPT-----------D--EPWKKELTEDGDTYLHLA IIHEATDAALKMIAL---S-RRDPFLNIQNNQRQTALHLAIITDQPLIVEQLLKAGCDAS LVDDHGNTALHIACR-KG--SLACFGLLTQGCS--------------------------- ---------------QHLSAILQTPNYN------------------------------GQ KCIHVVAIQGY---------------------------LSLLESLIQL-GAD--INAQEQ CNGRTALHLAVDLQNFDMVKLLI-EKGA--SVHSVTYGGHTPYHLTYGRS----NADIQK VLYELTSP---------------------------------------------------- -----HLRELP-ESDSED----SEDSDE-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------DYEERCQSE-VEDLYDD-IKVMGQ----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_aculeatus_ENSGACP00000006709 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MDVRRVS-NRDP---MDYN-LDSMEPKHGKAAP--CQDER----- -----LDSGVDSMKED-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -ELVNAFEELHVKMT------SDELAAE-----------H--EPWRSAVTDDGDTLLHLA VIQEAAEHAAQMIKL---S-HHHPFLNAQNHQRQTALHLAVITEQPGLVERLLKAGCDPR LADDGGNTALHIACK-KG--SLACFGVITQSCQ--------------------------- ---------------RHVASLASFPNYS------------------------------GH NCLHLASINGF---------------------------ISLVESLVRL-GAD--LNAQEQ CSGRTSLHLAVDLQNPALVRRLL-ELGA--DVNCVNYGGFTAYHLTYGRQ----SEEIRR QLYERTAQ---------------------------------------------------- -----ELRQLP-DSESDD----SDMEDM-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------DSSE------DE-LYDD-IQFGKQRVRL------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_rubripes_ENSTRUP00000012183 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MDLHRTS-ILNQ---MD----YSRESKEGKPAQ--ATEER----- -----LDSGLDSLREEE------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------YQ- -AVAAEFHRLRVECEPPQQQPDPAVTGE-----------L--HEWKRQITEDGDTLLHLA IIHEAKDYIKTMIDL---S-RNTDFLDLQNDQRQTPLHLAVITNQANVCLDLLASGCDPT LVDRHGDTPLHIACR-HG--NLLCFSVITQNCRP-------------------------- ---------------EHLSGMMGACNYQ------------------------------GQ NCLHVASVQGF---------------------------LSLVENLVNL-GAD--INAQEQ RNGRGALHLAVDQQNLSLVKLLL-SRGA--DPNLVSSGGHTPYHLTYGRH----DDDIRK ELYATTNP---------------------------------------------------- -----DLRELP-DSESDD----SEGEED-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EASD------DEVGYDD-IQWNGH----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_latipes_ENSORLP00000019865 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MP--------KQ---ADYN-FDNMEGKH-DMLQ--CHEDH----- -----LDSGLDSLKED-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -ELLTSFEDMTVS--------ARTEHTE-----------Y--EPWRSAITDDGDTLLHLA IIHESTEHVLQMIKL---S-HNHPFLNVQNHQRQTALHLAVITEQPQLVDKLLKAGADPV LVDNRGNTALHIACK-KG--SLACFGVITQNCQ--------------------------- ---------------RHLASMASFPNYS------------------------------GH NCLHLASINGY---------------------------VSLVESLVQL-GAD--INAQEP CSGRTALHLAVDLQNPTMVHCLL-DLGA--NVNCLNYGGFTPYHLTYGRQ----NEQIRC QLYERTAQ---------------------------------------------------- -----ELRELP-DSDSD-----SDMEDV-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------ELLEVDVSIPNK-FKTS-CDFYKQTLTD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_nigroviridis_ENSTNIP00000006529 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MDLHRTS-VLNQ---MD----YSRDPKEGKPAQ--ATDER----- -----LDSGLDSLREEE------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------YQ- -AVAAEFHRLRVECEPPPHKPEPAAAAE-----------L--PEWKTQVTEDGDTLLHLA IIHEASNHIKPMIAL---S-RNTDFLNLQNHQSQTPLHLAVITNQASVCLDLLASGCDPT LVDDRGDTPLHIACR-HG--NLLCFSVITQHCQP-------------------------- ---------------EHRGRMMAACNYH------------------------------GE NCLHLASVQGF---------------------------LSLVENLVSL-GAD--INAQEQ RNGRSSLHLAVDQQNLSLVRLLL-TRGA--DPNLVSSGGHTPYHLTYGRH----DDDIRR ELYSRTDP---------------------------------------------------- -----DLRELP-DSELDD----SEEEED-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EASD------EEVGYDD-IQWNGH----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_aculeatus_ENSGACP00000016549 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MALRRTS-ILNQ---MD----YGRESKDGKPAP--STEER----- -----LDSGLDSLKEDE------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------YQ- -AVAAEIRLLQLECEPPQRGRAAPAAGE-----------P--HEWKTQITEDGDTLLHLA IIHEAKDYIRTMIDL---S-KNTDFLNTQNDQRQTPLHLAVITNQAHVCQRLLASGCDPT LVDDSGDTPLHIACR-HG--NLPCFSVLTQNCPL-------------------------- ---------------EHLPTVMAACNYH------------------------------GQ NCLHLASVQGF---------------------------LSLVENMVDL-G-D--INSKEQ RNGRSALHLAVDQQNLSLVQLLL-KKGA--DPNLLTFGGHTPFHLTYGRN----DNDIRK ELYSLTDP---------------------------------------------------- -----ALRDLP-DSESDN----SEEEED-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------E-SD------EEVGYDD-IQWNGH----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_latipes_ENSORLP00000022136 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MDLHRNT-VLNQ---MD----YSEDPKEVKSSQ--LTEDR----- -----LDSGIDSLKEEE------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------YQ- -AVAAEIHRLQLDCEHKQ---PAAVTGE----------PL--QEWQTQITEEGDTLLHLA IIHEAKDFTQKMINM---T-KNTDFLNAQNDLRQTPLHLAVITNQPDVCYGLIVSGCNIT VVDNNGDTPLHIACR-HG--NLHCFSAITQNCRP-------------------------- ---------------EQLHTAMATWNYN------------------------------GQ NCLHLASIYGF---------------------------LLLVEKMVDL-GAD--INTREQ HNGRGALHLAVDQQNLCLVKLLL-KKGA--DPNLLTSGGYTPYHLTYGLD----NCDIRK ELHPLTHP---------------------------------------------------- -----DLRELP-DSDSEN----SEEDSD-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EEFD------EGVMYDD-IKLNGH----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_aculeatus_ENSGACP00000017867 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MASDDRRKDEPLEDGRADSGVD SYRSALRSEEPR------------------------EPSADFSGPRDKFTAVEER----- -----LDSAYGSSSLTAESLSEIVGGCT-------L----EEPAR--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GSELSDR-----------E--ENLLTTITEDGDTILHLA IIHEDRFIAHQLMQL-----FPQDVLNIQNNLYQSPLHLATYLNLVDVVKGLVEKGASLE LQDQEGNTALHVACQ-HG--QTECAGEMTREASP-------------------------- ---------------SKLAPVLETQNWR------------------------------GL ACLHLAALHRQ---------------------------HHIMKLLVNK-GAD--LNVQEG TSGKTALHLAAELHDVASVKLLL-SRGA--NVDAAMFNGCTPLHLAVGRQ----DAAIAH LLCQSGAD---------------------------------------------------- -----TMLRNM-EDETAL----DLADGN-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------DDILALFPFDD-IQISGRSVVSVKF---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_rubripes_ENSTRUP00000013362 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------RSSRPSTAMASDNCRKDELLEENRIDSGID SYRSILKSEEPR------------------------ESLGTEPGDA-KFSTAEER----- -----LDSSYGSSSITVDSLSDVVGGCK-------LSSPKEEQAQ--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------NCELSEQ-----------E--ENLLTTITEDGDTILHLA IIHEEEFIAQQLIQL-----FPKNVLDIQNNLYQSPLHLATYLNLTRVVRELVEKGASLE LQDHDGNTALHVACQ-QG--QVETASEMTKHVSP-------------------------- ---------------SKLAPVLETQNWK------------------------------GL ACLHLAALNRH---------------------------HQIISDLAKK-GAN--LNIQEG TSGKTALHFAVELRDITSVKLLL-SRGA--NVDTAMFNGCTPLHLAVGRR----DASIAT ILCQSGAD---------------------------------------------------- -----TMLRNM-EDETAL----DLADGN-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------EDILAVFPFDD-IQISGRSVVGVN----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >D_rerio_ENSDARP00000089603 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------MSRSGGGDQDGKPDLDENRIDSGID -----YAPREPR-----------------------EQFPSLANSEEKDKHSTDER----- -----LDSAYGSSSLTVDSLGDFIEECR---------ISKCESAT--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ECQYTEE-----------E--VNFLTTVTEDGDTILHLA IIHEELKFAQYLVDL-----FPPELMDIQNNLYQTPLHLATYLNLPIAVKILVEKGVSLE LQDQDGNTPLHVACE-HG--FWECANEMIQNTSP-------------------------- ---------------GKLANVLEAQNWR------------------------------GM TCLHVATLHKR---------------------------PRLMRLLMKN-GVH--LNIKEG TSGKTALHIAVEQRDVAAVKLLL-NKGA--NVDASMFNGCTALHLAVGRQ----DAAIAH LLCQAGAD---------------------------------------------------- -----KMIKNM-EDETAL----DLADGN-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------DDILALFPFDD-IQFMGRTVINYSM---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_nigroviridis_ENSTNIP00000019489 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------ER----- -----LDSSYGSSSITIESLSENVGGCT-------ISSPGEEPGQ--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SPELSEQ-----------E--ENLLTTITEDGDTILHLA IIHEEELFAQQLIQL-----FPKNVLDIQNNLYQSPLHLATYLNLTPVVRELMEKGASLE LQDRDGNTALHVACQ-QG--QTEMAGEMTRRVSP-------------------------- ---------------SQLAPILETQNWK------------------------------GL ACLHLAALNRQ---------------------------HQIISDLARK-GAN--LNIQEG TSGKAPLHFAVELRDITTVKLLL-SRGA--NVDPAMFNGCTPLHLAVGRR----DAAIAN ILCQSGAD---------------------------------------------------- -----MMLRNV-EDETAL----DLADGN-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------DDILAVFPFDD-IQISDKMYLCTI----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >D_rerio_ENSDARP00000045035 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------LSEDGDTVLHLA LIHEQWGVVQCLLQNIGMDNTWIPYLDIQNDLGQTALHLAVIVDSSECVRALLWSGASAE IQERGGNTPLHLAVR-EL--RTECVRELTSCS---------------------------- ---------------RTPPEHLNLTNYA------------------------------GV SALHLAVYRGN---------------------------FDVIKMLLEA-GAD--ANQRDL GSGRSPLHWAVESQKLETVELLL-SAGA--LVNQRSYAGHTPFYCALYRP----NKDIQT LLRAHGAT---------------------------------------------------- -----YSQDDE-EEEECR----ESEEEE-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------FDD-VIINGQ----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >R_norvegicus_ENSRNOP00000028944 ------------------------------------MADDDPF--G--TGQMFHLNTAL- THSI-FNAELY-STDIP--LST-DGPYLQILEQP--KQRGFRFRYVCEGPSHGGLPGASS EKNKKSYPQVKICN------------------------------------YVGPAKVIVQ LVTN-GKNIHLHAHSLVGKH-C-EDGICTVTAGPKDMVV-GFANLGILHVTKKKVFETLE ARMTEACIRGYNPGLLVHSDLAYLQA--------EGGGDRQLTDREKEIIRQAALQQTKE MDLSVVRLMFTAFLPDSTGSFTRRLEP-----VVSDAIYDSKAPNASN--LKIVR----- -----MDRTAGCVTGGEEIYLLCDKVQK-DDI-QI-----RFYEE--EENG-GVWEGFGD FSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIK--DKE EVQRKRQKLMP-NFSDS--------FGG-GSG-AG-------------------AGGGGM FGSGGG------------------------------------------------------ -------------GGGSTGSP--------GPGY--------------------------- ---------------------------GFP-HYGFPAYG--------------------- ------------------------------------------------------------ --GIAFHPGATKS------N------------------------------------TGIT HGTINTKFKNEPRDCA-----------KSDDREILNPPEKETQGEGPS--LFMASTKTEA IAPASTMEDKEEDVGFQDNLF---LEK----------------------------ALQLA KRHANALFDYAVTGD------VKMLLAV-----------Q--RHLTAVQDENGDSVLHLA IIHLHAQLVRDLLEVTSGSIS-DDIINMRNDLYQTPLHLAVITKQEDVVEDLLRVGADLS LLDRWGNSVLHLAAK-EG--HDKILGVLLKN----------------------------- ---------------SKAALLINHPNGE------------------------------GL NAIHIAVMSNS---------------------------LSCLQLLVAA-GAE--VNAQEQ KSGRTALHLAVEYDNISLAGCLLLEGDA--LVDSTTYDGTTPLHIAAGRG----STRLAA LLKAAGAD---------------------------------------------------- -----PLVENF-EPLYDL----DDSWEK-------------------------------- ------------AGED-------------------------------------------- ------------------------------------------EGV--------------- ------------------------------------------------------------ --------------------------VPGTTPLDMA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AN-WQ--------VFDI LNG-------KPY--EPVFTSDDIL--PQGDI---KQLTEDTRLQLCKLLEIPDPDKNWA TLAQKLGLGILNNAFRLSPAPSKTLM--DN-YEVSGGTIKELVEALRQMGYTEAIEVIQA AFRTP-ETTASSPV-TTAQAHL-LPLSSSSTRQHIDE-----LRDNDSVCDSGVETSFRK LSFS--ESLTGDGPLLSLNKMPHNYGQ---DGPIEGKI---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >E_caballus_ENSECAP00000013133 ------------------------------------MAEDDPYLGG--HEQMFHLES-L- NHTM-FNPELF-TQEVS--LPT-DGPYLQILEQP--KQRGFRFRYVCEGPSHGGLPGASS EKNKKSYPQVKICN------------------------------------YVGPAK-FVQ LVTN-GKHTHLHGSQSSGKNTV-KDGICTVTAGPKDMVV-GFANLGILHVTKKKVFETLE ARMTEACVRGYNPEILVHPDLRYLQA--------EGGGDRQLTDREKEVIHQAALQQTKE MDLSVVRLMFTAFLPDSTGSFTRRLEP-----VVSDAIYDSKAPNASN--LKIVR----- -----MDRTAGCVTGGEEIYLLCDKVQK-DDI-QI-----RFYEE--EENG-GIWEGFGD FSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIK--DKE EVQRKRQKLMP-NFSDS--------FGG-GSG-AG-------------------AGGGGM FGG-GG------------------------------------------------------ -------------GGGGAGST--------GPGY--------------------------- ---------------------------GFP-HYGFPTYG--------------------- ------------------------------------------------------------ --GITFHPGAAKS------N------------------------------------AGMK HGTIDTSCKNDPEGCD-----------ASDDREAVNLSGKGTETTARK---DGSRGRALL LSGVCVMGLGHPSHCLADNLF---LEK----------------------------AMQLA KRHANALFDYAVTGD------VKMLLAV-----------Q--RHLTAVQDENGDSVLHLA IIHLHAQLVRDLLEVTSGLVS-DDIINMRNDLYQTPLHLAVITKQEAVVEDLLRAGADLS LLDRFGNSALHLAAK-EG--HDKILGILLKH----------------------------- ---------------KKAALLINHPNAD------------------------------GL NAIHIAMMSNS---------------------------MPCLRLLVTA-GAD--VNAQER KSGRTALHLAVERDNISLAGCLLLEGEA--HVDSTTYDGTTPLHIAAGRG----STRLAA LLKAAGAD---------------------------------------------------- -----PLVENF-EPLYDL----DDSWEE-------------------------------- ------------NGED-------------------------------------------- ------------------------------------------EGV--------------- ------------------------------------------------------------ --------------------------VPGTTPLDMA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TS-WQ--------VFDI LNG-------KPY--EPEFTSDDLL--AQGDM---KQLTEDAKLQLYKLLEIPDPDKNWA TLAQKLGLGILNNAFRLSPAPSKTLM--DN-YEVSGGTIKELVDALRQMGYTEAVEVIQA AFCTS-GTAAPSPVTTTSQAPL-LPLAPASTRQQIDE-----LRE-DSVCDSGVETSFRR LSFT--ESLTSGSSLLTLNKMPHDYMQ---EGPIEGKI---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >X_tropicalis_ENSXETP00000046127 ------------------------------------MAQNIYDIDA-------HLDTYLP INPL-FQEPIYMTSEPN--LRSAEGPYIEITEQP--KQRGFRFRYVCEGPSHGGLPGASS EKNKKSYPQIKIHN------------------------------------YVGQVKIIVQ LITN-SKDIRLHAHSLVGKN-C-EDGICSLTVGPKDTIV-GFANLGILHVTKKKVIEILE ARMTDAFKKGHNAALLVHPELNYTYS--------E---DRQLNVREKEIIRQAAMQQAKD IDLSVVRLMFTAFLPDSEGRFTRSLEP-----VVSVPIFDSKAPNASN--LKIVR----- -----MDRTAGCVTGGEEVYLLCDKVQK-DDI-QV-----RFYEE--DENG-GFWEGFGD FSPTDVHRQFAIVFKTPKYKDVNITKAASVFVQLRRKSDYETSEPKPFLYYPEIK--DKE EVQRKRQKLMP-NFSDG--------FGGSGAG-SG-------------------GGGGGL YG--GG------------------------------------------------------ -------------GGAGGSGA--------GGSY--------------------------- ---------------------------GFS-SFSYNNYG--------------------- ------------------------------------------------------------ --GLNFHGGPMNS------S------------------------------------PCMK HES-QPQCEANQKHVE-----------TMNIQ---------DAPNEVVCLCFDTVQENEE A----PAREEREFCKLHDCNF---PRN----------------------------ALQLT KRHAASLFDYAVTGD------VRMLLAV-----------Q--RHLASVQDENGDNILHLS IIHQHSALVRIFLDITQGPVC-DDIINVRNDLYQTPLHLAVITQQPDTVQDIIKAGGDPL CLDRDGNSVLHLACK-EG--DASTLSILLKH----------------------------- ---------------KKTLEIINLPNND------------------------------GL NPIHVAVLSNC---------------------------VLCLRLLISA-RAD--VNAQEQ KSGKSALHLAVEQDNISLAGCLLLEGDA--CVDNTTYDGNTPLHIAVGRG----STKLTA LLKAAGAD---------------------------------------------------- -----SFVENF-EPLLRF----EDTQDE-------------------------------- ------------DDVD-------------------------------------------- ------------------------------------------EGI--------------- ------------------------------------------------------------ --------------------------VPGTKPLDIA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TS-DEARGCCMFWVLEI LNG-------KPY--KSEVAPEDSL--PQG------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_pygmaeus_ENSPPYP00000016712 ------------------------------------MAEDDPYLGR--PEQMFHLDPSL- THTI-FNPEVF-QPQMA--LPT-DGPYLQILEQP--KQRGFRFRYVCEGPSHGGLPGASS EKNKKSYPQVKICN------------------------------------YVGPAKVIVQ LVTN-GKNTHLHAHSLVGKH-C-EDGICTVTAGPKDMVV-GFANLGILHVTKKKVFETLE ARMTEACIRGYNPGLLVHPDLAYLQA--------EGGGDRQLGDREKELIRQAALQQTKE MDLSVVRLMFTAFLPDSTGSFTRRLEP-----VVSDAIYDSKAPNASN--LKIVR----- -----MDRTAGCVTGGEEIYLLCDKVQK-DDI-QI-----RFYEE--EENG-GVWEGFGD FSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIK--DKE EVQRKRQKLMP-NFSDS--------FGG-GSG-AG-------------------AGGGGM FGS-GG------------------------------------------------------ -------------GGGGTGST--------GPGY--------------------------- ---------------------------SFP-HYGFPTYG--------------------- ------------------------------------------------------------ --GITFHPGTTKS------N------------------------------------AGMK HGTMDTESEKDPEGCD-----------KSDDKNTVNLFGKVIETTEQDQEPSEATDGNGE VTLTYATGTKEESAGVQDNLF---LEK----------------------------AMQLA KRHANALFDYAVTGD------VKMLLAV-----------Q--RHLTAVQDENGDSVLHLA IIHLHSQLVRDLLEVTAGLIS-DDIINMRNDLYQTPLHLAVITNQEDVVEDLLRAGADLS LLDRLGNSVLHLAAK-EG--HDKVLSILLKH----------------------------- ---------------RKAALLLDHPNGD------------------------------GL NAIHLAMMSNS---------------------------LPCLLLLVAA-GAD--VNAQEQ KSGRTALHLAVEHDNISLAGCLLLEGDA--HVDSTTYDGTTPLHIAAGRG----STRLAA LLKAAGAD---------------------------------------------------- -----PLVENF-EPLYDL----DDSWEN-------------------------------- ------------AGED-------------------------------------------- ------------------------------------------EGV--------------- ------------------------------------------------------------ --------------------------VPGTTPLDMA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TS-WQ--------VFDI LNG-------KPY--EPEFISDDLL--AQGDM---KQLAEDVKLQLYKLLEIPDPDKNWA TLAQKLGLGILNNAFRLSPAPSKTLM--DN-YEVSGGTVRELVEALRQMGYTEAIEVIQA A---------SSPVKTTSQTHS-LPLSPASTRQQIDE-----LQDSDSVCDSGVETSFRK LSFT--ESLTSGASLLTLNKMPHDYGQ---EGPLEGKI---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_carolinensis_ENSACAP00000014173 ------------------------------------------------------LDG-LD YDDFQFGSHLIEQKELH--METAEGPFLTIIEQP--KQRGFRFRYGCEGPSHGGLPGASS EKGHKTYPTVKISN------------------------------------YVGLARIEVD LVTH-TDPPQVHAHSLVGKQ-CNEDGNCIVTVGPKDMTA-QFNNLGVLHVTKKNMMEIIK NKLQKQKMRNRSQT--LT------------------------ES-DHDELEQEAKELKKT MDLSIVRLRFSAYLRDSNGNFTLALKP-----VVSDPIHDSKSPGASN--LKISR----- -----MDKTAGSVRGGDEVYLLCDKVQK-DDIGRY-----DFPED--DENG---WQAL-D SPPTDVHKQYAIVFRTPPYHKTQIDRPVTVFLQLKRKRGGDVSDSKQFTYYPIVE--DKE EVERKRKKFLP-QFPQH--------FGG-GAP-M--------------------GGAGGG AGGFGS------------------------------------------------------ -------------G-GGAGKKLSF-----SAYP--------------------------- ---------------------------SFN-IYLSGTHP--------------------- ------------------------------------------------------------ --VGSYQ-G----------G------------------------------------RGIQ MPKAV--PVEDGDHQL-----------SEDG---K--QAFTEEKD-CL------------ ------------ELLQHAQEC---SSW----------------------------MLMLA RRSARALLDYAVTAD------PRMLLAV-----------Q--RHLAASQDENGDTPLHLA VIHEQTAVIAQLVQVAVSIPN-QQIINIANHLQQTPLHLAVITRQPRVAGFLLQAGADPT LLDRYGNSIIHLALQ-LG--EEEMLRTLLCHLG--------------------------- ---------------PHTLHLLETPNYL------------------------------GL FPVHLAVKCKR---------------------------LTCLELLVEK-GAD--VNAAER QSGRTPLHLAVEMENLNLATCLIKKLGA--DVNAQTSAGNTPLHLAAGMG----SPILTK MLIKAGAD---------------------------------------------------- -----IHCEND-EPMTAT----SSNSSN-------------------------------- -----------VGLIG-------------------------------------------- ------------------------------------------DHK--------------- ------------------------------------------------------------ -----------------EPTPCKRQQ-RGHIPLDLT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TS-QK--------VREI LLL-------ASLE-EPEREQSAAPPVSRQ-GFI-LSLNSDTFQCLEQLLNRDCHGADWV ELAKRLGLCSLVETYRDTPSPSRRLL--LS-YELAGGSLKGLLEALDTMGLTEGVKLLRR PESFPKVQST---E----------------------------LKEDSGYGSQSVE--EES ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >B_taurus_ENSBTAP00000027016 ------------------------------------MAEDDPYLGG--HEQMFHLDP-L- NHTM-FSPELF-QPEMP--LPTADGPYLQILEQP--KQRGFRFRYVCEGPSHGGLPGASS EKNKKSYPQVKICN------------------------------------YVGPAKVIVQ LVTN-GKNIHLHAHSLVGKH-C-EDGVCTVTAGPKDMVV-GFANLGILHVTKKKVFETLE ARMTDACIRGYNPGLLVHPDLAYLQA--------EGGGDRQLTDRDKEIIRQAALQQTKD MDLSVVRLMFTAFLPDSTGSFTRRLEP-----VVSDAIYDSKAPNASN--LKIVR----- -----MDRTAGCVTGGEEIYLLCDKVQK-DDI-QI-----RFYEE--EENG-GIWEGFGD FSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIK--DKE EVQRKRQKLMP-NFSDS--------FGG-GSG-AG-------------------AGGGGM FGS-GG------------------------------------------------------ -------------GGGGAGST--------GPGY--------------------------- ---------------------------GFP-HYGFPTYG--------------------- ------------------------------------------------------------ --GITFHTGTTKS------N------------------------------------AGMK HGTIDTPSKNDPESCG-----------KSDDREVVNLSEQVTETTEQD---GGSCKGGSA ANLTCSVGVKEENRSFQDNLF---LEK----------------------------AMQLA KQHANALFDYAVTGD------VKMLLAV-----------Q--RHLTAVQDENGDSVLHLA IIHLHNQLVRDLLEVTSGLIS-DEIINMRNDLYQTPLHLAVITRQEAVVEDLLRAGADLS LLDRLGNSVLHLAAK-EG--HDKILGILLKH----------------------------- ---------------KKAAQLIDHPNGE------------------------------GL NAIHVAMMSNS---------------------------LPCLLLLMAA-GAD--VNAQER KSGRTALHLAVEHDNVSLAGCLLLEGDA--HVDSTTYDGTTPLHIAAGRG----STRLAA LLKAAGAD---------------------------------------------------- -----PLVENF-EPLYDL----DDSWDE-------------------------------- ------------DGED-------------------------------------------- ------------------------------------------EGV--------------- ------------------------------------------------------------ --------------------------VPGTTPLDMA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------SS-WQ--------VFDI LNG-------KPY--EPEFTSDDLL--AQGDM---KQLTEDAKLQLYKLLEIPDPDKNWA TLAQKLGLGILNNAFRLSPAPSKTLM--DN-YEVSGGTIKELVEALRQMGYTEAIDVIQA AFCTA----DTSPAKTTSQAHS-LPFAPASTRPQIDE-----LRD-DSICDSGVETSFRK LSFT--ESLTSGTSLLTLNKVPHDYGQ---EGPIEGKI---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >H_sapiens_ENSP00000226574 ------------------------------------MAEDDPYLGR--PEQMFHLDPSL- THTI-FNPEVF-QPQMA--LPTADGPYLQILEQP--KQRGFRFRYVCEGPSHGGLPGASS EKNKKSYPQVKICN------------------------------------YVGPAKVIVQ LVTN-GKNIHLHAHSLVGKH-C-EDGICTVTAGPKDMVV-GFANLGILHVTKKKVFETLE ARMTEACIRGYNPGLLVHPDLAYLQA--------EGGGDRQLGDREKELIRQAALQQTKE MDLSVVRLMFTAFLPDSTGSFTRRLEP-----VVSDAIYDSKAPNASN--LKIVR----- -----MDRTAGCVTGGEEIYLLCDKVQK-DDI-QI-----RFYEE--EENG-GVWEGFGD FSPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIK--DKE EVQRKRQKLMP-NFSDS--------FGG-GSG-AG-------------------AGGGGM FGS-GG------------------------------------------------------ -------------GGGGTGST--------GPGY--------------------------- ---------------------------SFP-HYGFPTYG--------------------- ------------------------------------------------------------ --GITFHPGTTKS------N------------------------------------AGMK HGTMDTESKKDPEGCD-----------KSDDKNTVNLFGKVIETTEQDQEPSEATVGNGE VTLTYATGTKEESAGVQDNLF---LEK----------------------------AMQLA KRHANALFDYAVTGD------VKMLLAV-----------Q--RHLTAVQDENGDSVLHLA IIHLHSQLVRDLLEVTSGLIS-DDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLS LLDRLGNSVLHLAAK-EG--HDKVLSILLKH----------------------------- ---------------KKAALLLDHPNGD------------------------------GL NAIHLAMMSNS---------------------------LPCLLLLVAA-GAD--VNAQEQ KSGRTALHLAVEHDNISLAGCLLLEGDA--HVDSTTYDGTTPLHIAAGRG----STRLAA LLKAAGAD---------------------------------------------------- -----PLVENF-EPLYDL----DDSWEN-------------------------------- ------------AGED-------------------------------------------- ------------------------------------------EGV--------------- ------------------------------------------------------------ --------------------------VPGTTPLDMA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TS-WQ--------VFDI LNG-------KPY--EPEFTSDDLL--AQGDM---KQLAEDVKLQLYKLLEIPDPDKNWA TLAQKLGLGILNNAFRLSPAPSKTLM--DN-YEVSGGTVRELVEALRQMGYTEAIEVIQA A---------SSPVKTTSQAHS-LPLSPASTRQQIDE-----LRDSDSVCDSGVETSFRK LSFT--ESLTSGASLLTLNKMPHDYGQ---EGPLEGKI---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_troglodytes_ENSPTRP00000028033 ------------------------------------MAEDDPYLGR--PEQMFHLDPSL- THTI-FNPEVF-QPQMA--LPTADGPYLQILEQP--KQRGFRFRYVCEGPSHGGLPGASS EKNKKSYPQVKICN------------------------------------YVGPAKVIVQ LVTN-GKNIHLHAHSLVGKH-C-EDGICTVTAGPKDMVV-GFANLGILHVTKKKVFETLE ARMTEACIRGYNPGLLVHPDLAYLQA--------EGGGDRQLGDREKELIRQAALQQTKE MDLSVVRLMFTAFLPDSTGSFTRRLEP-----VVSDAIYDSKAPNASN--LKIVR----- -----MDRTAGCVTGGEEIYLLCDKVQK-DDI-QI-----RFYEE--EENG-GVWEGFGD FSPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIK--DKE EVQRKRQKLMP-NFSDS--------FGG-GSG-AG-------------------AGGGGM FGS-GG------------------------------------------------------ -------------GGGGTGST--------GPGY--------------------------- ---------------------------SFP-HYGFPTYG--------------------- ------------------------------------------------------------ --GITFHPGTTKS------N------------------------------------AGMK HGTMDTESKKDPEGCD-----------KSDDKNTVNLFGKVIETTEQDQEPSEATVGNGE VTLTYATGTKEESAGVQDNLF---LEK----------------------------AMQLA KRHANALFDYAVTGD------VKMLLAV-----------Q--RHLTAVQDENGDSVLHLA IIHLHSQLVRDLLEVTSGLIS-DDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLS LLDRLGNSVLHLAAK-EG--HDKVLSILLKH----------------------------- ---------------KKAALLLDHPNGD------------------------------GL NAIHLAMMSNS---------------------------LPCLLLLVAA-GAD--VNAQEQ KSGRTALHLAVEHDNISLAGCLLLEGDA--HVDSTTYDGTTPLHIAAGRG----STRLAA LLKAAGAD---------------------------------------------------- -----PLVENF-EPLYDL----DDSWEN-------------------------------- ------------AGED-------------------------------------------- ------------------------------------------EGV--------------- ------------------------------------------------------------ --------------------------VPGTTPLDMA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TS-WQ--------VFDI LNG-------KPY--EPEFTSDDLL--AQGDM---KQLAEDVKLQLYKLLEIPDPDKNWA TLAQKLGLGILNNAFRLSPAPSKTLM--DN-YEVSGGTVRELVEALRQMGYTEAIEVIQA A---------SSPVKTTSQAHS-LPLSPASTRQQIDE-----LRDSDSVCDSGVETSFRK LSFT--ESLTSGASLLTLNKMPHDYGQ---EGPLEGKI---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_mulatta_ENSMMUP00000034946 ------------------------------------MAEDDPYLGR--PEQMFHLDPSL- THTI-FNPEVF-QPQMA--LPTADGPYLQILEQP--KQRGFRFRYVCEGPSHGGLPGASS EKNKKSYPQVKICN------------------------------------YVGPAKVIVQ LVTN-GKNIHLHAHSLVGKH-C-EDGICTVTAGPKDMVV-GFANLGILHVTKKKVFETLE ARMTEACIRGYNPGLLVHPDLAYLQA--------EGGGDRQLGDREKELIRQAALQQTKE MDLSVVRLMFTAFLPDSTGSFTRRLEP-----VVSDAIYDSKAPNASN--LKIVR----- -----MDRTAGCVTGGEEIYLLCDKVQK-DDI-QI-----RFYEE--EENG-GVWEGFGD FSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIK--DKE EVQRKRQKLMP-NFSDS--------FGG-GSG-AG-------------------AGGGGM FGS-GG------------------------------------------------------ -------------GGGGTGST--------GPGY--------------------------- ---------------------------SFP-HYGFPTYG--------------------- ------------------------------------------------------------ --GITFHPGTTKS------N------------------------------------AGMK HGTMDTESKKDSEGCD-----------RSDDRNTVNLFGKVIETTEHNQEPSEATDGNGE VTLTYATRAKEESARVQDNLF---LEK----------------------------AMQLA KRHANALFDYAVTGD------VKMLLAV-----------Q--RHLTAVQDENGDSVLHLA IIHLHSQLVRDLLEVTSGLIS-DDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLS LLDRLGNSVLHLAAK-EG--HDKVLSILLKH----------------------------- ---------------KKAALLLDHPNGD------------------------------GL NAIHLAMMSNS---------------------------LPCLLLLVAA-GAD--VNAQEQ KSGRTALHLAVEHDNISLAGCLLLEGDA--HVDSTTYDGTTPLHIAAGRG----STRLAA LLKAAGAD---------------------------------------------------- -----PLVENF-EPLYDL----DDSWEN-------------------------------- ------------AGED-------------------------------------------- ------------------------------------------EGV--------------- ------------------------------------------------------------ --------------------------VPGTTPLDMA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AS-WQ--------VFDI LNG-------KPY--EPEFTSDDLL--AQGDM---KQLAEDVKLQLYKLLEIPDPDKNWA TLAQKLGLGILNNAFRLSPAPSKTLM--DN-YEVSGGTVRELVEALRQMGYTEAIEVIQA A---------SSPVKTTSQAHS-LPLSPASTRQQIDE-----LRDSDSVCDSGVETSFRK LSFT--ESLTSGGSLLTLNKMPHDYGQ---EGPLEGKI---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >R_norvegicus_ENSRNOP00000026988 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MSDARKGPDEADDSQCDSGIE SLRSLRSLPDPAAAPVSGSSHSGCPQP-------WSHAPKTDKEPEGKEDADGER----- -----ADSTYASSSLTESLPLLERPEAK-DPNPPTPSSPVSP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AGVLSPQ-----------Q--LEALTYISEDGDTLLHLA VIHEAPSVLFCCLAF-----LPQEVLDIQNNLYQTALHLAVHLDQPDVVRALVLKGASRI LQDQHGDTALHVACQ-RQ--NLACACCLLEEQPEPGRQ---------------------- ---------------PSHPLDLQLKNWQ------------------------------GL ACLHIATLQRN---------------------------QPLIELLLQN-GAD--IDAQEG TSGKTALHLAVETQERSLVQFLL-QAGA--RVDARMLNGCTPLHLAAGRG----LNSISS TLCEAGAD---------------------------------------------------- -----SLLLNV-EDETPQ----DLA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------EDLLSYLPFDD-LKISGKPLLCTD----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >D_melanogaster_FBpp0080402 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPSPTKAAEAATKATATSDCSCSAASVEQRAPSNAANPSSSLATSGKIGGKTQD Q-------------------------------------TAAINKQKEFAVPNETSDSGFI SGPQSSQIFSEEIVPDSEEQ--------------DKDQQESAPQKEQPVVLDSGI----- -----IDEEEDQEEQEKEEEHQDTTTATADSM--------RLKHSA-DTGIPQWTVESHL VSRGEQLNNLGQSSSTQITGRSKVQSSTAS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------T ANANPSGSGATSSAP------PSSINIM-----------N-AWEQFYQQNDDGDTPLHLA CISGSVDVVAALIRM---APH-PCLLNIQNDVAQTPLHLAALTAQPNIMRILLLAGAEPT VRDRHGNTALHLSCI-AG--EKQCVRALTEKFGATEIHEAHRQYGHRSNDK--------- -----AVSSLSY---ACLPADLEIRNYD------------------------------GE RCVHLAAEAGH---------------------------IDILRILVSH-GAD--INAREG KSGRTPLHIAIEGCNEDLANFLL-DECEKLNLETATYAGLTAYQFACIMN----KSRMQN ILEKRGAE---------------------------------------------------- -----TVTPPDSDYDSSD------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IEDLDDTKMYDRFGDP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------RYFVSYNGGNPMTVA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >B_taurus_ENSBTAP00000035832 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------HWAAQLPRVAAA---------ADPAAAPNLVHASRRAP--QGPPAA REGGHFGSLTRSVRRTCNPERRRGVGSCWDRARRAGAAGMSEARKGPDETDESQYDSGIE SLRSLRSLPESTPRPASGPSDGGGPQP-------WIHSPGTAKEPEEKEDTDGER----- -----ADSTYGSSSLTEPLSLSGDPRTE-D---AVPDSPLPV------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AGALSPQ-----------Q--LEALTYISEDGDTLIHLA VIHEAPAVLLYCLAL-----LPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRV LQDRHGDTALHVACQ-RQ--HLACARCLLEGQPEPGRG---------------------- ---------------PPHSLDLQLQNWQ------------------------------GL ACLHIATLQRN---------------------------RPLMELLLQN-GAD--IDVQEG TSGKTALHLAVETQERGLVQFLL-QAGA--RVDARMLNGCTPLHLAAGRG----LSGISS TLCEAGAD---------------------------------------------------- -----SLLRNV-EDETPQ----DLA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------EDPFALLPFDD-LKISGKPLLCAD----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_carolinensis_ENSACAP00000014483 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------GLLSPQ-----------L--LETFAFVSEEGDTLLHLA IIHCVPYIALCCIAE-----LPVEALEIQNDLFQTPLHLSVYLEQSLVVQALVLKGVNTA LQDRSGNTPLHLACE-QQ--SLECTQMLLIQEPTTDNNRVA------------------- ---------------RNSLQDLQLQNWQ------------------------------GL TCLHISTLKGN---------------------------LQLMTLLVKN-GAD--INVQDG TSGKTPLHLAVENHDEIAVKHLL-QMGA--QVDAQMYNGCTPLHLAVGRK----DTTIAA VLCHSGAD---------------------------------------------------- -----TLLRNM-EDETAQ----DLADGN-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------DDILTLLPFDD-LKISGKPVVCSS----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_musculus_ENSMUSP00000024742 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MSDARKGPDEADDSQCDSGIE SLRSLRSLPEPTAAPGSGSSQSGCPQP-------WRHAPETHKEPE-KEDADGER----- -----ADSTYASSSLTESFPLLERPEAK-DPSPPAPGSPLPP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AGVLSPQ-----------Q--LEALTYISEDGDTLLHLA VIHEAPSVLFCCLAF-----LPQEVLDIQNNLYQTALHLAVHLDQPDVVRALVLKGASRI LQDQHGDTALHVACR-RQ--NLACACCLLEEQPEPGRQ---------------------- ---------------LSHPLDLQLKNWQ------------------------------GL ACLHIATLQRN---------------------------QPLIELLLQN-GAD--IDVQEG TSGKTALHLAVETQERSLVQFLL-QAGA--RVDARMLNGCTPLHLAAGRG----LNSISS TLCEAGAD---------------------------------------------------- -----SLLLNV-EDETPQ----DLA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------EDLLSYLPFDD-LKISGKPLLCTD----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_domestica_ENSMODP00000025861 ------------------------------------------------------------ ----------------------ADGPYLQILEQP--KQRGFRFRYVCEGPSHGGLPGASS EKNKKSYPQVKICN------------------------------------YVGPAKVIVQ LVTN-GKHVHLHAHSLVGKH-C-EDGICTVTAGPKDMVV-GFANLGILHVTKKKVYETLE ARMTDACIRGYNPGLLVHPELNYLQP--------EGGGERQLTDREKEIIRQAAVQQTKE MDLSVVRLMFTAFLPDSTGSFTRRLEP-----VVSDAIYDSKAPNASN--LKIVR----- -----MDRTAGCVTGGEEIYLLCDKVQK-DDI-QI-----RFYEE--EENG-GFWEGFGD FSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIK--DKE EVQRKRQKLMP-NFSDR------------------------------------------- ------------------------------------------------------------ --------------------------------Y--------------------------- ---------------------------GFA-PYGF-SYA--------------------- ------------------------------------------------------------ --GIPFHPGTTKS------N------------------------------------AGMK HGTLDSSSVQGHAGCD-----------ESDDRSSAELSGKILKTTEQD--DKPRVTGRDE ITLTCTV-VEEEDCRLQGDPF---LEK----------------------------AMQLA KRHASALFDYAVTGD------VKVLLAV-----------Q--RHLTAVQDDNGDNVLHLA IIHLHAELVRNLLEVISGLLS-DDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADVS LLDRLGNSALHLAAK-EG--DDKILNILLKH----------------------------- ---------------KKILPLIDHPNGE------------------------------GL NAIHLAMLINS---------------------------MPCLRLMIAA-GAD--VNAQEQ TSGRTALHLAVEQENVSLAGCLLLEGDA--FVDSTTYDGTTPLHIAAGRG----STKLAA LLKAAGAD---------------------------------------------------- -----PLLENF-EPLYDL----DDVWDQ-------------------------------- ------------DGED-------------------------------------------- ------------------------------------------EGV--------------- ------------------------------------------------------------ --------------------------VPGTTPLDMA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AN-SQASG-----VYDI LNG-------KPY--QSESTSSDLL--AQGDM---KQLDEEAKLQLYKLLEMPDPDKNWS TLAQKLGLGILNNAFRLSPAPSKTLM--DN-YEVSGGTIRELVDALRQMGYTEAIEVIQK AFSAS---------QPTEQIYS-LPPSPSCIRQQLGD--ICKLQDNESVCDSGVETSFRK LSFT--ESLTSTGALITLNKMPCDYGQ---ETSIEGKV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_musculus_ENSMUSP00000029812 ------------------------------------MADDDPY--G--TGQMFHLNTAL- THSI-FNAELY-SPEIP--LST-DGPYLQILEQP--KQRGFRFRYVCEGPSHGGLPGASS EKNKKSYPQVKICN------------------------------------YVGPAKVIVQ LVTN-GKNIHLHAHSLVGKH-C-EDGVCTVTAGPKDMVV-GFANLGILHVTKKKVFETLE ARMTEACIRGYNPGLLVHSDLAYLQA--------EGGGDRQLTDREKEIIRQAAVQQTKE MDLSVVRLMFTAFLPDSTGSFTRRLEP-----VVSDAIYDSKAPNASN--LKIVR----- -----MDRTAGCVTGGEEIYLLCDKVQK-DDI-QI-----RFYEE--EENG-GVWEGFGD FSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIK--DKE EVQRKRQKLMP-NFSDS--------FGG-GSG-AG-------------------AGGGGM FGS-GG------------------------------------------------------ -------------GGGSTGSP--------GPGY--------------------------- ---------------------------GYS-NYGFPPYG--------------------- ------------------------------------------------------------ --GITFHPGVTKS------N------------------------------------AGVT HGTINTKFKNGPKDCA-----------KSDDEESLTLPEKETEGEGPS--LPMACTKTEP IALASTMEDKEQDMGFQDNLF---LEK----------------------------ALQLA RRHANALFDYAVTGD------VKMLLAV-----------Q--RHLTAVQDENGDSVLHLA IIHLHAQLVRDLLEVTSGLIS-DDIINMRNDLYQTPLHLAVITKQEDVVEDLLRVGADLS LLDRWGNSVLHLAAK-EG--HDRILSILLKS----------------------------- ---------------RKAAPLIDHPNGE------------------------------GL NAIHIAVMSNS---------------------------LPCLLLLVAA-GAE--VNAQEQ KSGRTALHLAVEYDNISLAGCLLLEGDA--HVDSTTYDGTTPLHIAAGRG----STRLAA LLKAAGAD---------------------------------------------------- -----PLVENF-EPLYDL----DDSWEK-------------------------------- ------------AGED-------------------------------------------- ------------------------------------------EGV--------------- ------------------------------------------------------------ --------------------------VPGTTPLDMA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AN-WQ--------VFDI LNG-------KPY--EPVFTSDDIL--PQGDM---KQLTEDTRLQLCKLLEIPDPDKNWA TLAQKLGLGILNNAFRLSPAPSKTLM--DN-YEVSGGTIKELMEALQQMGYTEAIEVIQA AFRTP-ATTASSPV-TTAQVHC-LPLSSSSTRQHIDE-----LRDSDSVCDSGVETSFRK LSFT--ESLTGDSPLLSLNKMPHGYGQ---EGPIEGKI---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_familiaris_ENSCAFP00000015815 ------------------------------------MAEDDTYLGA--HEQMFHLDP-L- THTI-FNPELF-QPEMP--LPTADGPYLQILEQP--KQRGFRFRYVCEGPSHGGLPGASS EKNKKSYPQVKICN------------------------------------YVGPAKVIVQ LVTN-GKNIHLHAHSLVGKH-C-EDGICTVTAGPKDMVV-GFANLGILHVTKKKVFETLE ARMTEACTKGYNPGLLVHPDLAYLQA--------EGGGDRQLTDREKEIIRQAALQQTKE MDLSVVRLMFTAFLPDSTGSFTRRLEP-----VVSDAIYDSKAPNASN--LKIVR----- -----MDRTAGCVTGGEEIYLLCDKVQK-DDI-QI-----RFYEE--EENG-GIWEGFGD FSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIK--DKE EVQRKRQKLMP-NFSDS--------FGG-GSG-AG-------------------AGGGGM FGS-GG------------------------------------------------------ -------------GGGGAGST--------GPGY--------------------------- ---------------------------GFP-HYGFPTYG--------------------- ------------------------------------------------------------ --GITFHPGTTKS------N------------------------------------AGMK HGTIDTPSKNDSEGCG-----------KNVDREAVNLSGKVTEPTEQD---KESSMGVDE VTLTYTVGIKEENSRFQDNLF---LEK----------------------------AMQLA KRHANALFDYAVTGD------VKMLLAV-----------Q--RHLTAVQDENGDSVLHLA IIHLHAQLVRDLLEVTSGLIS-DDIINMRNDLYQTPLHLAVITKQEAVVDDLLRAGADLS LLDRLGNSVLHLAAK-EG--QDKILSILLKH----------------------------- ---------------KKAALLMDHPNGE------------------------------GL NAIHIAVMSNS---------------------------MPCLLLLVAA-GAD--VNAQER KSGRTALHLAVEHDNISLAGCLLLEGDA--HVDSTTYDGTTPLHIAAGRG----STRLAA LLKAAGAD---------------------------------------------------- -----PLVENF-EPLYDL----DDSWEK-------------------------------- ------------DGED-------------------------------------------- ------------------------------------------EGV--------------- ------------------------------------------------------------ --------------------------VPGTTPLDMA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TN-WQ--------VFDI LNG-------KPY--EPEFTSDDLL--AQGDM---KQLTEDAKLQLYKLLEIPDPDKNWA TLAQKLGLGILNNAFRLSPAPSKTLM--DN-YEVSGGTIKELVEALRQMGYTEAIEVIQA AFCAP-ETAAPSPGKGAPQTLS-LPLSSASTRSPVDE-----VRD-DSICDSGVETSFRK LSFT--ESLTSGSSLLTLNKAPHEYGQ---EGPIEGKI---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >H_sapiens_ENSP00000275015 ------------------------------------------------------------ ------------------------------------------------------------ -----------MNQRRSESRPGNHRLQAYAEPGKGDSGGAGPLSGSARRGRGGGGAIRVR RPCWSGGAGRGGGPAWAVRLPTVTAGWTWPALRTLSSLRAGPSEPHSPGRRPPRAGRPLC QADPQPG---KAARRSLEPDPAQ------TGPRPARAAGMSEARKGPDEAEESQYDSGIE SLRSLRSLPESTSAPASGPSD-GSPQP-------CTHPPGPVKEPQEKEDADGER----- -----ADSTYGSSSLTYTLSLLGGPEAE-D---PAPRLPLPH------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------VGALSPQ-----------Q--LEALTYISEDGDTLVHLA VIHEAPAVLLCCLAL-----LPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRA LQDRHGDTALHVACQ-RQ--HLACARCLLEGRPEPGRG---------------------- ---------------TSHSLDLQLQNWQ------------------------------GL ACLHIATLQKN---------------------------QPLMELLLRN-GAD--IDVQEG TSGKTALHLAVETQERGLVQFLL-QAGA--QVDARMLNGCTPLHLAAGRG----LMGISS TLCKAGAD---------------------------------------------------- -----SLLRNV-EDETPQ----DLT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------EESLVLLPFDD-LKISGKLLLCTD----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_pygmaeus_ENSPPYP00000018632 ------------------------------------------------------------ ------------------------------------------------------------ -----------MNQRRSESRPGNHRLQAYAEPMKGKKEGRGPLSGSARRGRGGGGAIRVR RPCWSGGAGRGGGPAWAVRLPTVTAGWTWPALRTLFSLRAGPSEPHSPGRRPPRAGRPFC QADPQPG---KAARRSPEPDPAQ------TRPPRARAAGMSEARKGPDEADESQYDSGIE SLRSLRSLPESTSAPASGPSD-GSPQP-------CTHPPGPAKEPQEKEDADGER----- -----ADSTYGSSSLTETLSLLGGPEAE-D---PVPRLPLPH------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------VGALSPQ-----------Q--LEALTYISEDGDTLVHLA VIHEAPAVLLCCLAL-----LPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRA LQDRHGDTALHVACQ-RQ--HLACARCLLEGRPEPGRG---------------------- ---------------TSHSLDLQLQNWQ------------------------------GL ACLHIATLQKN---------------------------QPLMELLLRN-GAD--IDVQEG TSGKTALHLAVETQERGLVQFLL-QAGA--QVDARMLNGCTPLHLAAGRG----LMGISS TLCKAGAD---------------------------------------------------- -----SLLRNV-EDETPQ----DLT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------EESLVLLPFDD-LKISGKLLLCTD----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_gallus_ENSGALP00000020084 ---------------------------------GLKMAGEDPYIMGVSDPQMFAMDQLMG MSTI-FNNTGYITSDLP--LRTADGPYLQIIEQP--KQRGFRFRYVCEGPSHGGLPGASS EKNKKSYPQVKICN------------------------------------YVGPAKVIVQ LVTN-GKYVHLHAHSLVGKF-C-EDGVCTVNAGPKDMVV-GFANLGILHVTKKKVFETLE TRMIDACKKGYNPGLLVHPELGYLQA--------EGCGDRQLTEREREIIRQAAVQQTKE MDLSVVRLMFTAFLPDSNGGFTRRLDP-----VISDAIYDSKAPNASN--LKIVR----- -----MDRTAGCVTGGEEIYLLCDKVQK-DDI-QI-----RFYEE--DENG-GMWEGFGD FSPTDVHRQFAIVFKTPKYRDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIK--DKE EVQRKRQKLMP-NFSDG--------YGG-GS---G-------------------AGGGGM FG---------------------------------------------------------- ---------------GGGGGA--------GSGF--------------------------- ---------------------------SYP-SYGYSAFG--------------------- ------------------------------------------------------------ --GMHFHPGTTKS------N------------------------------------AGMK HELSNSTVKKDEESSD-----------KQSDKWDTKHDVKVETVEKNECRTSGHNEEKED ASLCCKDEGNKPKCGCQDGLF---LEK----------------------------AMQLA KRHCNALFDYAVTGD------VRMLLAV-----------Q--RHLTAVQDDNGDNVLHLS IIHLHRELVKNLLEVMPDMNY-NNIINMRNDLYQTPLHLAVITKQAEVVEDLLKAGANVN LLDRHGNSVLHLAAA-EG--DDKILSLLLKH----------------------------- ---------------QKASSMIDLSNGE------------------------------GL SAIHMVVTANS---------------------------LSCLKLLIAA-GVD--VNAQEQ KSGRTALHLAVEQENVPLAGCLLLEGDA--DVDSTTYDGTTPLHIAAGRG----FTKLAA VLKAAGAD---------------------------------------------------- -----PHVENF-EPLFDV----EEDVKD-------------------------------- ------------DDDD-------------------------------------------- ------------------------------------------EGI--------------- ------------------------------------------------------------ --------------------------VPGTTPLDMA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AN-WE--------VYDI LNG-------KPYI-AAAAVSEDLL--SQGPL---RELNESSKQQLYKLLETPDPSKNWS TLAEKLGLGILNNAFRLSPSPSKTLL--DN-YKISGGTVQELIAALTQMDHTEAIEVIQK ALSSS-QRQSHQEDNTIEAFPS-LSPT-SFAKEETGELYNHKFQDPESTCDSGVETSFRK LSFTYSDSLNSKSS-ITLSKMTLGYRKAQCKAVIYLTR---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_troglodytes_ENSPTRP00000031139 ------------------------------------------------------------ ------------------------------------------------------------ -----------MNQRRSESRPGNHRLQAYAEPGKGDSGGAGPLSGSARRGRGGGGATRVR RPCWPGGAGRGGGPAWAVRLPTVTAGWTWPALRTLSSLRAGPSEPHSPGRRPPRAGRPLC QADPQPG---KAARRSLEPDPAQ------TGPRPARAAGMSEARKGPDEAEESQYDSGIE SLRSLRSLPESTSAPASGPSD-GSPQP-------CTHPPGPAKEPQEKEDADGER----- -----ADSTYGSSSLTETLSLLGGPEAE-D---PAPRLPLPH------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------VGALSPQ-----------Q--LEALTYISEDGDTLVHLA VIHEAPAVLLCCLAL-----LPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRA LQDRHGDTALHVACQ-RQ--HLACARCLLEGRPEPGRG---------------------- ---------------TSHSLDLQLQNWQ------------------------------GL ACLHIATLQKN---------------------------QPLMELLLRN-GAD--IDVQEG TSGKTALHLAVETQERGLVQFLL-QAGA--QVDARMLNGCTPLHLAAGRG----LMGISS TLCKAGAD---------------------------------------------------- -----SLLRNV-EDETPQ----DLT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------EESLVLLPFDD-LKISGKLLLCTD----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >E_caballus_ENSECAP00000017452 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------RAGAAGMSEARKGPDETDESQYDSGIE SLRSLRSLPEPAPAPAPGPSDGGGPQP-------WTHPPRTAKEPQEKEDTDGER----- -----ADSTYGSSSLTEPLTLLRGPETE-D---TDPGSPLPP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AGALSPR-----------Q--LEALTYISEDGDTLVHLA VIHEAPAVLLCCLAL-----LPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRV LQDRHGDTALHVACQ-RQ--HLACARCLLEGRPEPGRG---------------------- ---------------PPHSLDLQLQNWQ------------------------------GL ACLHIATLQRN---------------------------RPLMELLLQN-GAD--IDAQEG TSGKTALHLAVETQERGLVQFLL-QAGA--RVDARMLNGCTPLHLAAGRG----LSSISS TLCEAGAD---------------------------------------------------- -----SLLRNV-EDETPQ----DLA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------EDPLALLPFDD-LKISGKPLLCAD----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_aegypti_AAEL000709-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------MYPSKGGASSAGGFTHLSLSEGQNKQDKFSTDSGAIDSGFH SGQNFSSDNLFSSSSSASVQPEEAPVQ--------ALYQSGSQKQPLEEDSRT------- -----FDSGVDLDSSQQNPSSA-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------DPMKV DDLCISLRQMQMKSKEQ----QQALHLM-----------K--WEKYFHQNDDGDTYLHLA VIHEATEAVYNLIHA-----APRPWLDIQNDIGQTPLHLSVLTGQPKIVRRLMVAGAKTG IRDVEGNTPLHLACL-HQ--RTDCAKELLNP----------------------------- -----------------LSQDLEQWNYN------------------------------GK RCVHIAAETSN---------------------------IEILRSLVSA-GAD--INSREG KSGQTPLHIAIEYNNEQLVNFLL-DECPKLRLEQVTYAGLTAYQLAAIQH----NQTLLT GLKSHGAE---------------------------------------------------- -----PLTPP--ESDYEE----EDSEEDEQMSSYYGSNAFG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------ATFPGLSTINVA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_mulatta_ENSMMUP00000029868 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MSEARKGPDEADESQYDSGIE SLRSLRSLPEPTSAPASGPSD-GSPQP-------CTHPPGPAKEPQQKEDADGER----- -----ADSTYGSSSLTESLSLLGGPEAE-D---PAPRPPLPH------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------VGALSPQ-----------Q--LEALTYISEDGDTLVHLA VIHEAPAVLLCCLAL-----LPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRA LQDRHGDTALHVACQ-RQ--HLACARCLLEGRPEPGRG---------------------- ---------------TSHSLDLQLQNWQ------------------------------GL ACLHIATLQKN---------------------------QPLMELLLQN-GAD--IDVQEG TSGKTALHLAVETQERGLVQFLL-QAGA--QVDARMLNGCTPLHLAAGRG----LMGISS TLCKAGAD---------------------------------------------------- -----SLLRNV-EDETPQ----DLT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------EESLVLLPFDD-LKISGKLLLCTD----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_gorilla_ENSGGOP00000008704 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------AGGPLC QADPQSG---KAARRSPEPDPAQ------TGPPPARAAGMSEARKGPDEAEESQYDSGIE SLRSLRSLPESTSAPASGPSD-GSPQP-------CTHPPGPAKEPQEKEDADGER----- -----ADSTYGSSSLTETLSLLGGPEAE-D---PAPRLPLPH------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------VGALSPQ-----------Q--LEALTYISEDGDTLVHLA VIHEAPAVLLCCLAL-----LPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRA LQDRHGDTALHVACQ-RQ--HLACARCLLEGRPEPGRG---------------------- ---------------TSHSLDLQLQNWQ------------------------------GL ACLHIATLQKN---------------------------QPLMELLLRN-GAD--IDVQEG TSGKTALHLAVETQERGLVQFLL-QAGA--QVDARMLNGCTPLHLAAGRG----LMGISS TLCKAGAD---------------------------------------------------- -----SLLRNV-EDETPQ----DLT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------EESLVLLPFDD-LKISGKLLLCTD----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_guttata_ENSTGUP00000003727 ---------------------------------GLKMAAEDSYIMGVSDPQMFTVDQFMG MNAL-FNSTNYITADLP--LRTADGPYLQIIEQP--KQRGFRFRYVCEGPSHGGLPGASS EKNKKSYPQVKICN------------------------------------YVGPAKVIVQ LVTN-GKYVHLHAHSLVGKF-C-EDGVCTVIAGPKDMVV-GFANLGILHVTKKKVLETLE TRMIDACKKGYNPGLLVHPELSYLQA--------EGCEDRQLTERERELIRQAAIQQTKD MDLSVVRLMFTAFLPDSNGSFTRRLDP-----VISDAIYDSKAPNASN--LKIVR----- -----MDRTAGCVTGGEEIYLLCDKVQK-DDI-QI-----RFYEE--DENG-GMWEGFGD FSPTDVHRQFAIVFKTPKYRDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIK--DKE EVQRKRQKLMP-NFSDG--------YGG-GS---G-------------------TGGGGM YG---------------------------------------------------------- ---------------GAGGSA--------GSGF--------------------------- ---------------------------SFP-SYGYSAFG--------------------- ------------------------------------------------------------ --GMHF-PGTTKS------N------------------------------------AGMK HGLSNCTAEQDRKSCD-----------KQNDQWDMKCDVKAEAVERTECRTSAVNEKKED SVFSCKTEASEADCRWRDALF---LEK----------------------------AMQLA RRHCNALFDYAVTGD------VKMLLAA-----------Q--RHLTAVQDDNGDNVLHLA IIHLHRDLVKNLLEVMPDLNY-NDIINMRNDLYQTPLHLAVITKQAKVVEDLLKAGADVS LLDRHGNSVLHLAAT-EG--DDKILSLLLRH----------------------------- ---------------ENVSPMVNLPNAE------------------------------GL SAIHMVVMANS---------------------------MSCLKQLIAA-GVN--VNAQEQ KSGRTALHLAVEQENIPLAGCLLLEGDA--DVDSTTYDGTTPLHIAAGRG----STKLAA VLKAAGAN---------------------------------------------------- -----PHIENF-EPLFDL----DYVKED-------------------------------- ------------EDDD-------------------------------------------- ------------------------------------------EGI--------------- ------------------------------------------------------------ --------------------------VPGTTPLDMA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AN-SE--------VYDI LNG-------KPY--ESAEVLEDLL--TQGHL---RELSENSKMQLYKLLELPDPTKNWS TLAQKLGLGILNNAFRLSPSPSKTLL--DN-YEVSGGTVQELITALRQMDHTEAIEIIQE ALSIS-RRPPAPEDSTAKALPS-SSPL-TFANGETGELFNSRFQDLESTCDSGVETSFRK LSFTSSDSLTSKSS-LTLGKMALGY------------G---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_intestinalis_ENSCINP00000024868 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MSNKAPCYKLEKQNVDFGDR IDSGFDSITSREEERFDSGHVSYTLPTTTTHLPTSKPSNDKELVDNIRPMAKEMY----- ATEEYVDSGFGSASMTDE------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EREKFIMTLRNPEQK------PKDLDEM------------SESLHCFLPDEDGDTFLQMA IIHEKIDLAFDVIQS---CTR-PALLNVENSNMQTALHLAVLTDQPEITRCLVAYGANVS CVDKKGNTPLHIASE-MG--FPLQVEMLTTPLDPLEDPGLQT------------------ ---------------NSIPENVDVLNYS------------------------------GL AAIHLAARNNR---------------------------ESVIRKLVKVPGCN--INIEDS KSGRTALHHAIECRSKDAMKILL-KRGI--QVNALSFDDCSALHMAVSKG----MRSEVN TLIHHKAD---------------------------------------------------- -----MHLVTR-DDNDVF----DLAGRNHQMLR--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QLYTHQKLKH------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_guttata_ENSTGUP00000007782 ------------------------------------------------------LDG-ID YDDFSFGSHMMEQKEPL--METVEGPYLVIIEQP--KQRGFRFRYGCEGPSHGGLPGASS EKGRKTYPTVKICN------------------------------------YTGMARIEVD LVTH-SDPPRVHAHSLVGKQ-CNEAGNCVTIVGPKDMTA-QFSNLGVLHVTKKNMMEIMK EKLKQQKMRNRSRL--LT------------------------EV-ELREIELEAKELKKV MDLSIVRLRFTAYLRDSSGNFTLALQP-----VISDPIHDSKSPGASN--LKISR----- -----MDKTAGSVRGGDEVYLLCDKVQK-DDI-EV-----RFYED--DENG---WQAFGD FSPTDVHKQYAIVFRTPPYHKPKIDRPVTVFLQLKRKRGGDVSDSKQFTYYPVVE--DKE EVERKRKKVLP-QFPQH--------FGG-GSH-M--------------------GGAGGG AGGFGS------------------------------------------------------ -------------G-GGGNLSFPY-----SSGL--------------------------- ---------------------------TYNSIYSPGPHP--------------------- ------------------------------------------------------------ --VGSYQ-G----------G------------------------------------VQMK GPEA----------EG-----------PESD---R--QAPAEESTYCK------------ ------------ELQKHEAHNPRRTGN----------------------------LLGLS RRNAHALLDYSVTAD------PRMLLAV-----------Q--RHLAASQDENGDTPLHLA IIHEQTAVIKQLIDIIVSIPH-QQIINISNNLQQTSLHLAVITKQPQVVQLLLQAHADPT LLDRYGNSLLHLALQ-TG--DEEMLRTLLAHLG--------------------------- ---------------SAAPYLLCLPNFH------------------------------GL LPVHLAVKAKS---------------------------LACLDLLVRT-GAD--VNAVER QSGRTPLHLAVDMENLNMATHLVKKLGA--DINSRNFAGNTPLHLAAGLG----SPTLTK LLLKAGAD---------------------------------------------------- -----VLCEND-EPLSLS----SSEASS-------------------------------- ------------DTDT-------------------------------------------- ------------------------------------------DPE--------------- ------------------------------------------------------------ -----------------EQEAGHRQR-RCHTSLDLT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------RS-HK--------VMPM LL---------CVL-QRSKQPSLRPPSSEAPRLV-LSLDSEALQGLEQLLNQDCSGSDWI ELAKRLGLCSLVETYKDTPSPSVSLL--RS-YELAGGSLGGLLEALDSMGLHNAVRMLHK TEALEKLQST---E----------------------------LKEDSAYGSESVE--EE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_domestica_ENSMODP00000023618 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------AGARAMSEPGKGPDEPDEGQYDSGIE SWRSLRSLPEP--ALTLGPSD-GGPLP-------RTGTRAPPGTKEDLKEEDGER----- -----MDSAYGSSSLTEPLPPLGSPEAVEG---GEPRVSEAR------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------VGVLGQQ-----------Q--LEALTYISEDGDTLLHLA VIHEAPTVLFFCLTL-----LPQEVLDIQNDLFQTALHLAVYLDQPGTVRALVQRGASRT LQDRHGDTALHLACQ-HQ--HLDCARYLLEAPPDRGRS---------------------- ---------------QQHHPELLLQNWQ------------------------------GL ACLHLATLQRN---------------------------RMLMELLLQN-GAD--IDIQEG TSGKTALHLAVETQDRSLVRFLL-RAGA--RVDARMHNGCTPLHLATGRH----LSGIVA TLCQAGAD---------------------------------------------------- -----SFLRNI-EDETPQ----DLA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------DNPLTLLPFDD-LKISGKPLLCTD----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_nigroviridis_ENSTNIP00000005249 ------------------------------------MAADEHYLHA--SNQIFDLPM-LD APWD-FTPFPAMAQAPS--LRTVDGPFLQIVEQP--KQRGFRFRYGCEGPSHGGLPGASS EKNRNTYPTINVNN------------------------------------YQGPARVVVQ LVTALHQSPQLHAHSLVGKQ-C-EKGICTADLQPKLPVLCSFPNLGILHVTKKNVTKTLE ERMVEAFRMGHNYGVCIHPEIDGQQG--------EVRVPRELTDHQRSLISSAAAVQAKD MDLSVVRLMFTVFLPDSDGGFSRRLEP-----VVSDPIYDSKAPNASN--LKIVR----- -----MDRTAGCVSGGEEVYLLCDKVQK-DDI-QV-----RFYEE--DDSG-LTWEALGD FSPTDVHRQFAIVFKTPKYRDQNLQKPTSVFVQLKRKSDNETSEPKPFTYHPQVIGSDKE EVQRKRQKTLP-NFHDF--------LHR-GGG-PG-------------------AGGPGS AG--GG------------------------------------------------------ -------------GGSGCPGSDAHHLSFSPPGF--------------------------- ----------------------------FQ-GFTTYKNT--------------------- ------------------------------------------------------------ --VRRTSGRQRGK------PQVPFLVRKHPDQLITFNLMV----------------GGVQ ASQGGAVSSD----ED-----------GDPEDGSGS----APRRKARP---------GIG S-HWLDPRPPETAGAV----------------------------------------LEVT SGQVEALFRYSVTGE------AAHLLAT-----------Q--RSLMDAQDEDGDSVLHLA VLHHQQEVLKSLVQVLSLLPG-QDVLNARNHLYQTPLHLAVLTQQREAVQALLLAGADPT LADRHGNTPLHLASQQGG--DGGMVGFLLQD----------------------------- ---------------EGMRGLLELPNRA------------------------------GL CPIHLAVLANQ---------------------------LSSLRELLEG-GAN--VESQER SCGRSALHLATERDNVSLAGCLLLEGNA--NVDSCTFDGSTPLHVAAGRG----SAKLTA LLVAAGAD---------------------------------------------------- -----PRKENF-EPLFFL----QTSWLQ-------------------------------- ------------SDKE-------------------------------------------- ------------------------------------------EGY--------------- ------------------------------------------------------------ --------------------------VPGTTPMNIA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ATKQQ--------VVEL LNG-------KEY--EPKPSLREPKPPPESDL---VSLGLQVKQQVCQALE---REALWE RLAQALGLGILNTAFRLSPVPARTLL--DS-YEVSGGTVSELLAALRSLGECQARSILEG ALFPSVDQGAGAANRRTGLCPP-LPAG----EQLKVE-----LGLDGEACDSGVELS--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_aculeatus_ENSGACP00000022290 ------------------------------------------------------------ -----------------------DGPFLQIVEQP--KQRGFRFRYGCEGPSHGGLPGASS EKTSKTYPAVKISN------------------------------------YQGPARVVVQ LVTALTTHPQLHAHSLVGKQ-C-DKGICITDLQPKDSTI-SFPNLGILHVTKKNVAKTLE ERMVEAARLGYNCGISIHPDIDVLQG--------EVRVPRELNDDQRRVISSAASLQAKE MDLSVVRLMFTAFLPNSDGGFSRRLEP-----VVSEPIYDSKAPNASN--LKIVR----- -----MDRTAGCVSGGEEVYLLCDKVQKVDDI-QV-----RFYEE--DDSG-LTWEAMGD FSPTDVHRQFAIVFKTPKYRDQNLQKPTSVLVQLKRKSDNETSEPKPFTYHPQII--DKE EVQRKRQKTLP-NFQDFSGHGGGGGLYR-GGG-GG-------------------GRGPAA GG--GP------------------------------------------------------ -------------GSAG------------GGGY--------------------------- ----------------------------FH-GFTTYNYG--------------------- ------------------------------------------------------------ --GAAAGGGGVGG------G------------------------------------GGFS TGYSAEASEDNQAADD-----------KHPDDDSGSDVGVGPAVGEGP---------KEG EVGGEEPEPPRGTHLLMYTLF---TVT----------------------------PLQMR CDQLQALFQYSVTGD------SAFLLAA-----------Q--RQLMSVQDEDGDTGLHLA VLHSQQEALKSLTQVVSALPG-EEVLNMRNHLYQSPLHLAVITQQREAVEALLLAGADPT LTDRHGNTPLHLASRVEG--GGGMVQFLLQH----------------------------- ---------------REMIVRLSVSTVT------------------------------GL CAIHLAVLANQ---------------------------LSSLRELLEG-GAN--VEAQER SCGRTALHLATERDNVSLAGCLLLEGNA--KVDSFTFNGSTPLHIAAGRD----SVKLTA LLMAAGAD---------------------------------------------------- -----PQRENF-EPLFFR----EEDCCD-------------------------------- ------------EEKED------------------------------------------- ------------------------------------------EGY--------------- ------------------------------------------------------------ --------------------------IPGTTPLNMA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TT-AQ--------VLEL LNG-------KEY--KPKCPQRSIT-PAQGDL---ASLDVEVKQQVCCALE---SEGCWE KLAHSLGLGILNTAFGLSPSPAKTLL--QS-YEVSGGTVRELLDGLRSVGDCRALNVLEE VLRHH-DEKEEALRR---------PADGSLVRDLKAD-----IRIDSGVCDSGVELS--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_carolinensis_ENSACAP00000015967 ------------------------------------------------------------ ----------------------ADGPYLQIVEQP--KQRGFRFRYVCEGPSHGGLPGASS EKNKKSYPQVKICN------------------------------------YAGPAKVIVQ LVTN-GKHVHLHAHSLVGKH-C-EQGVCTVNAGPKDMVV-GFPNLGILHVTKKRVLDTLE TRMIDACKRGYNPGLLVHPDLNYIQA--------ESGGERQLTEREREIIHQAALHQTKE MDLSVVRLMFTAFLPDSTGSFTRRLQP-----VLSDPIYDSKAPNASN--LKIVR----- -----MDRTAGCVTGGEEIYLLCDKVQK-DDI-QI-----RFYEE--DENG-GVWEGFGD FSPTDVHRQFAIVFKTPKYRDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIK--DKE EVQRKRQKLMP-NFSDS--------Y-G-GSG-AG-------------------AGGGGM YG--GG------------------------------------------------------ -------------GGGGGGGV--------GGGY--------------------------- ---------------------------GYS-PYGFSGYG--------------------- ------------------------------------------------------------ --AMHFHSSTNKT------G------------------------------------AGMK HGTFYLPLLHLKEATG-----------IYCNNEMVSIRLQPSVPATQK----DFSLNVQL HMLICTLFMRWLSFLPADALF---LEK----------------------------AMELA KYHANALFDYAITGD------VKRLLAV-----------Q--RHLTTAQDENGDNVLHLS IIHLQAELMRNLLEVIADLNS-ADVLDVRNDLYQTPLHLAVITKQAGAVRDLLGTGADVS LLDRHGNSVLHLAVN-QG--DEKVLNILLSH----------------------------- ---------------KEASQMKDLPNGE------------------------------GL AAIHLAVMANS---------------------------VSCLRRLFAA-GVD--VNAQEQ KSGKTALHLAVEQGSISLAGCLLLEGEA--FVDSTTYDGTTPLHIAAGRG----STKLTA LLKAAGAD---------------------------------------------------- -----PHIENF-EPLFEQ----DDVKDN-------------------------------- ------------EGED-------------------------------------------- ------------------------------------------EGI--------------- ------------------------------------------------------------ --------------------------VPGTTPLDMA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TT-MI--------VYDI LNG-------KSS--KTKVASDDLL--TPGNM---KELSDDVKSQLYKLLEVPDLNKNWS MLAQKLGLGILNNAFRLSPSPSKTLL--DN-YEVSGGTVKELVDALREMDYPEAVEIIQ- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_domestica_ENSMODP00000016796 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MAAPVGPVKSVDGEFVDEW----- -----CDSGLGSLGPDGLGASGEGAKAGADE----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------NEEEEPA-----------SWAPEVFGYVTEDGDTALHLA VIHQHEAFLDFLLHF----TAGTEYLDLQNDLGQTALHIAAILGQATITQKLRAAGAGLC VAEQGGHTPLHLACR-AG--AHACARALLGPPEGQT--------------T--------- -----DGEDEEEEDEHERLEQLECTNYQ------------------------------GH TPLHLAVIYKD---------------------------MEMVQLLREA-GAD--LNKPEP TCGRSPLHLAVEAEAAEVLELLL-NGGA--DPKARMYGGRTPLGSATLRP----DPLLAC LLRAHGAP---------------------------------------------------- -----EPESEE-EDDSSP----QGSDSD-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EGDEYDDIVIHGSRSRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_gambiae_AGAP007938-PA ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KFRRRIK LIVKKMHPTRGSAMNNVSITDS-------------------------------------- --------------------------------------SGQPMSDKKDYCDSANTDSGFL SGHNLNSSEDIVSEEQHRAVENNQNIA-------GSHTVGASEKQPIETETD-------- -----LDSGMIPDEELE------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---SGNLGLMDICER------FDRLMKR-----------D--WMKTFQQDEFGETQLHLA VYERNEDLISKLVAN-----VPQQFLNIQNDAAQTALHLAVLTEQPKVVRRLLVGGINQS IRDMDGNTALHLACS-LG--RAQIAKELLTPSACSELSQGVSY----------------- ---------------TKLPQDLEQWNYD------------------------------GK TCVHLAAEAGS---------------------------METLRCLINA-GAD--INAREG KSGMSALHISIEKGNEELANFLL-DECPLLSLEAVTYAGMTAYQLALIQD----KRILIG DLTKRGAE---------------------------------------------------- -----QISLPASDSESDS----EDEMISNYYGASAFS----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------ATFSGLSAINVS----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >E_caballus_ENSECAP00000012098 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MAGVACLGKASD---ADEW----- -----CDSGLGSLGPDAAAPGGPGLG---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AELGPGL-----------SWAPLVFGYVTEDGDTALHLA VIHQHEPFLDFLLGF----AAGTEYLDLQNDLGQTALHLAAILEEASTVEKLYAAGAGLR VAERGGHTALHLACR-VG--AHACARVLLQPRPRRPRGAPSTYLAQDPDHTPNTDHTPVA LYPDPDLEKEEDESEEDWKLQLEAENYE------------------------------GH TPLHVAVIHKD---------------------------AEMVQLLREA-GAD--LNKPEP TCGRSPLHLAVEAQAADVLELLL-RAGA--DPTARMYGGRTPLGSATLRP----NPNLAR LLRAHGAP---------------------------------------------------- -----EPEDED-EKPGPC---SSSSSDS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------DSGDEGDEYDDIVVHRGRSQNPLPPAPASKPLPDDPNPK-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_guttata_ENSTGUP00000008206 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QTPLHLAVYLEQPSVIQALIHKGVNPG LQDRNGNTPLHLACE-QQ--YLQCAQQLLKGPATPDGTTQP------------------- ---------------HGYHQDLQLQNWQ------------------------------GL ACLHISTLKGN---------------------------IPMMSLLLES-GAN--IDVREG TSGKTPLHLAVECHNCRAVQFLL-RNGA--YVDAQMYNGCTPLHLAVGRK----DAAIAA ILSHSGAD---------------------------------------------------- -----TLLRNM-ENETAQ----DLADGN-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------DDLLALLPFDD-LKISGKPVVCSE----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_aculeatus_ENSGACP00000001732 ------------------------------------------------------------ ----------------PSSGVSAHGPYIQIIEEP--KQRGFRFRYECEGPSHGGLPGASS EKNRRTYPTVKINN------------------------------------YVGHARVEVQ LVSH-TDPPSVHAHSLVGRH-CTENGTCTLDIGPNDLAA-SFSNLGILHVTKKGVVEVLS RRLRDERKRLKGPHCHLTGTHT---S--------QASHNTLPHS-EENGLLKEAKELGKV MDLNIVRLKFTAYLQDSNGGFTRGLKP-----VVSNPIYDSKSPNASN--LKISR----- -----MDKTCGTVLGGDEIFLLCDKVQK-DDI-EI-----RFYEED-DEGG---WEAFGD FSPTDVHKQVLSSFRTPPYHTAEIERPVTVFLQLKRKKAGDSSDPKQFTYTPQVQ--DKE EVLRKKQKPLP-HYEP---------STA-------------------------------F PHLLHR------------------------------------------------------ -------------K-FTVDLCFPS------AGF--------------------------- ---------------------------QFN-QQMN---G--------------------- ------------------------------------------------------------ --GVFFTEGFAGF------G------------------------------------GGAQ MSGSH--PQTG--VTQ-----------QHSG-SPAQQQLLQLGER--------------- ------------RCPDGDSLQ---GSR----------------------------ASQGA RRTAAALLQYCSTGD------ARVLLAI-----------Q--RHLCGVQDGNGDTPLHLA VIHQQTGVIQQLIHTLLSSQQ-QNILNTANHLQQTPLHLAVITRQVKVLEVLLRAGADPS LLDKDGRNPLHLAAL-AG--DTASLRLLLAHLG--------------------------- ---------------ERHAHLVNTADYH------------------------------GL HPLHLSVRRDG---------------------------ERCLRLLVEG-GAK--INAPEQ KSGNTALHLAVRENLFKVACTLITELKA--DVNTTTFGGNTPLHLAAGLG----SPTLCS MLIAAGAD---------------------------------------------------- -----KNVEND-EPLFFT----SSSDEE-------------------------------- ------------QDED-------------------------------------------- ------------------------------------------E-------------PI-- ------------------------------------------------------------ --------------------------RGGHTPLHLT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------RC-QKQ-------VRIL LNP-------GLSPKSSLHSR--------GAG---SRVDEDTLSRLVEVLSV--GDVPWR KLAEKLGMMTLTHLYLDSPTPCHQLL--QH-YQLGGGPVQGLVEALQSLGLTEGVRLLRS SELRDDKHST---D----------------------------ATVDSGFGSQPID--EE- EEPPVANQ---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_carolinensis_ENSACAP00000009364 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------VLGFVTEDGDTALHLA VIHEHEAFLDSILQF----MQGTDYLDIQNDLGQTALHIAVILGASDFVGKLVSAGAGLC VQEKGGHTALHLACR-EG--QRECAQQLLAPVLGQRPCEG-------------------- ---------------NSSRAQLDCTNYDVCSHHSYGGGRNEQRGKNQCSDNCLLSLSLGF TPLHLAVLRKD---------------------------LDMVGLLVSG-GSD--INKPEL SCGRSPLHLAVEAQSPEMVEHLL-RAGA--NPEARMYVGYTPMYSAIHRP----NEKIAQ LLRAFGSE---------------------------------------------------- -----EPD---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >R_norvegicus_ENSRNOP00000025913 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MDEGPVDLRTRPK--GI-SG AALPLRKRPLRPASPEPAAPRGPAG-------PLDALRSNCDVPAVPGPPHCVAR----- ------------------------------------------------------------ --PEALYYQGPLMP---MYSTPTMAPPFPL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --LNLPTHPYSMICP------VEHPLSA-----------D--IAMATRVDEDGDTPLHIA VVQNNKTAVYRILSL---FKLGNREVDVHNNLRQTPLHLAVITTLPDIVRLLVTAGASPM ALDRHGQTAVHLACE-HR--SPSCLQALLDSAT--------------------------- ----------------PGSVDLEARNYE------------------------------GL TALHVAVNTGC---------------------------QEAVLLLLER-GAD--IDAVDI KSGRSPLIHAVENNSLNMVQLLL-LHGA--NVNAQMYSGSSALHSASGRG----LLPLVR TLVRSGAD---------------------------------------------------- -----SGLKNC-HNDTPL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MVA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------RS-----------RRVI DILRGKASRA--------ASGSQPDPSPDQSATNSPESSSRLSSNGLQS-SP-SSSPSLS PPKDAPSFPMTPQNYFLPATSAPAFLPFPGVLRGPGRPVAPSPAPGSS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_musculus_ENSMUSP00000032815 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MAGVACLGKTAD---ADEW----- -----CDSGLGSLGPDAAAPGGPGLG---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AELGPEL-----------SWAPLVFGYVTEDGDTALHLA VIHQHEPFLDFLLGF----SAGTEYLDLQNDLGQTALHLAAILGEASTVEKLYAAGAGVL VAERGGHTALHLACR-VR--AHTCACVLLQPRPSHPRDASDTYLTQSQDCTPDTSHAPAA VDSQPNPENEEEPRDEDWRLQLEAENYD------------------------------GH TPLHVAVIHKD---------------------------AEMVRLLRDA-GAD--LNKPEP TCGRTPLHLAVEAQAASVLELLL-KAGA--DPTARMYGGRTPLGSALLRP----NPILAR LLRAHGAP---------------------------------------------------- -----EPEDED-DKLSPC-SSSGSDSDS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------DNRDEGDEYDDIVVHSGRSQNRQPPSPASKPLPDDPNPA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_latipes_ENSORLP00000003676 ------------------------------------------------------------ ------------------------GPYIQIIEEP--KQRGFRFRYECEGPSHGGLPGASS EKNRRTYPTVKINN------------------------------------YVGQARVEVQ LVTH-TDPPRVHAHSLVGRN-CTESGTCVLDVGPNDLTA-SFSNLGILHVTKKGVVDVLT RRLREERRRQTGGHCHLT------------------------DA-EEASIQKEVKELSKS MDLNIVRLKFTAYLQDSNGGFTRALKP-----VVSNPIYDSKSPNASN--LKISR----- -----MDKTCGSVLGGDEIFLLCDKVQK-DDI-EI-----RFYEED-DEGG---WEAFGD FSPTDVHKQYAIVFKTPPYHSTEIQRSVTVFLQLRRKKAGDSSDPKQFTYIPQVQ--DKE EVLRKKQKPLP-HYESW--------RGG-------------------------------G RGGGAG------------------------------------------------------ -------------G-FGGGASGGA------GGF--------------------------- ---------------------------QFH-QQMNGGGG--------------------- ------------------------------------------------------------ --GTFYSEGFTGF------T------------------------------------GAAQ MSGSA--PQQ----SD-----------RPAG-SPLQQQLLQIA----------------- ------------------ATL---NNR----------------------------VSQSA RQTAAALLQYCRTGD------TRALLAI-----------Q--THLCSVQDTNGDTPLHLS IIHLQTGVTQQLIHTLLSSRQ-QRILNTTNHLQQTPLHLAVITRQPKVVEALLRAGADPT LPDKDGRSPLHLAAL-AG--DSSLLRLLLSHMG--------------------------- ---------------ERHSHLVNTPDYH------------------------------GL QPLHLAVRRDG---------------------------ERCLRLLIEG-GAK--INAPEQ KSGNTALHLAVRENLFKVACTLITELKA--DTNACTFGGNTPLHLAASLG----SPTLCS MLIAAGAD---------------------------------------------------- -----KNIQND-EPLSCS----SSSDEE-------------------------------- ------------VDES-------------------------------------------- ------------------------------------------ELTREELAERAASQPIN- ------------------------------------------------------------ ----------------------TRKRRAGHTPLDLA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TC-HK--------VRNL LQS-------GQSPTASRHSNKKIKANSGAEG---SGLNEDTLAQLVEVLSV--SDIPWI KLAEKLGMMTLTHLYQDSPTPCHHLL--QH-YKLGGGAVDDLVKALQSLGLTEGIRLLRN AELQEDKHST---D----------------------------ATVDSGFSSQPME--EE- EQ-----Q---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_pygmaeus_ENSPPYP00000011138 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MAGVACLGKAAD---ADEW----- -----CDSGLGSLGPDAAAPGGPGLG---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AELGPGL-----------SWAPLVFGYVTEDGDTALHLA VIHQHEPFLDFLLGF----SAGTEYMDLQNDLGQTALHLAAILGDASTVEKLYAAGAGLC VAERRGHTALHLACR-VG--AHACARALLQPRPRRPREAPETYLAQAPDRTPDTDHTPVA LYPDSDLEK--EESEEDWKLQLEAENYE------------------------------GH TPLHVAVIHKD---------------------------VEMVRLLRDA-GAD--LDKLEP TCGRSPLHLAVEAQAADVLELLL-RAGA--NPAARMYGGRTPLGSAMLRP----NPILAR LLRAHGAP---------------------------------------------------- -----EPEGED-EKSGPC----SSSSDS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------DSGDEGDEYDDIVVHSGRSQTRLPPTPASKPLPDDPGPI-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_familiaris_ENSCAFP00000008409 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MAGVACLGKAAE---ADEW----- -----CDSGLGSLGPDAAAPGGPGLG---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AELGPGL-----------SWAPLVFGYVTEDGDTALHLA VIHQHEPFLDFLLGF----AAGTEYLDLQNDLGQTALHLAAILGEASAVEKLYAAGAGLH IAERGGHTALHLACR-MR--AHACARVLLQPRPRCSRGAPNTYLAQGPDRTSDTDHPPVA SYPEPDLEKEDEENEEDWKLQLEAENYE------------------------------GH TPLHVAVIHKD---------------------------AEMVRLLREA-GAD--LNKPEP TCGRSPLHLAVEAQAADVLELLL-RAGA--DPAARMYGGRTPLGSATLRP----NPILAR LLRAHGAP---------------------------------------------------- -----EPEDED-DRPGPC-SSSSSSSDS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------DSGDEGDEYDDIVVHSGRSQSRLPPTPASKPLPDDP--V-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_gorilla_ENSGGOP00000002452 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LQNSRQSPATGGRLRGVPEAAGAMAGVACLGKAAD---ADEW----- -----CDSGLGSLGPDAAAPGGPGLG---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AELGPGL-----------SWAPLVFGYVTEDGDTALHLA VIHQHEPFLDFLLGF----SAGTEYMDLQNDLGQTALHLAAILGEASTVEKLYAAGAGLC MAERRGHTALHLACR-VG--AHACARALLQPRPWCPREAPDTYLAQGPDRTPDTNHTPVA LYPDSDLEKEEEESEEDWKLQLEAENYE------------------------------GH TPLHVAVIHKD---------------------------VEMVRLLRDA-GAD--LDKPEP TCGRSPLHLAVEAQAADVLELLL-RAGA--NPAARMYGGRTPLGSAMLRP----NPILAR LLRAHGAP---------------------------------------------------- -----EPEGED-EKSGPC----SSSSDS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------DSGDEG-----------VSQEERQGSPAGGSG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_troglodytes_ENSPTRP00000058822 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LQNSRQSPVTGGRLRGAPEAAGAMAGVACLGKAAD---ADEW----- -----CDSGLGSLGPDAAAPGGPGLG---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AELGPGL-----------SWAPLVFGYVTEDGDTALHLA VIHQHEPFLDFLLGF----SAGTEYMDLQNDLGQTALHLAAILGEASTVEKLYAAGAGLC VAERRGHTALHLACR-VG--AHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVA LYPDSDLEKEEEESEEDWKLQLEAENYE------------------------------GH TPLHVAVIHKD---------------------------VEMVRLLRDA-GAD--LDKPEP TCGRSPLHLAVEAQAADVLELLL-RAGA--NPAARMYGGRTPLGSAMLRP----NPILAR LLRAHGAP---------------------------------------------------- -----EPEGED-EKSGPC----SSSSDS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------DSGDEG-----------VSQEERQGSPAGGSG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_musculus_ENSMUSP00000113851 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MPRCPAGAMDEGPVDLRTRPK--GT-PG AALPLRKRPLRPASPEPATTRSPAG-------PLDALRSGCDVPVVPGPPHCVAR----- ------------------------------------------------------------ --PEALYYQGPLMP---IYSTPTMAPHFPL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --LNLPTHPYSMICP------MEHPLSA-----------D--IAMATRVDEDGDTPLHIA VVQNNIAAVYRILSL---FKLGSREVDVHNNLRQTPLHLAVITTLPDMVRLLVTAGASPM ALDRHGQTAIHLACE-HR--SPSCLQALLDSAT--------------------------- ----------------SGSVDLEVRNYE------------------------------GL TALHVAVNTGC---------------------------QEAVLLLLER-GAD--IDAVDI KSGRSPLIHAVENNSLNMVQLLL-LHGA--NVNAQMYSGSSALHSASGRG----LLPLVR TLVRSGAD---------------------------------------------------- -----SGLKNC-HNDTPL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MVA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------RS-----------RRVI DILRGKASRA--------ASGSQPEPSPDQSATNSPESSSRLSSNGLQS-SP-SSSPSLS PPKDAPGFPATPQNFFLPTTSTPAFLPFPGVLRGPGRPVPPSPAPGSS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_mulatta_ENSMMUP00000031129 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MAGVACLGKAAD---ADEW----- -----CDSGLGSLGPDAAAPGGPGLG---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AELGPGL-----------SWAPLVFGYVTEDGDTALHLA VIHQHEPFLDFLLGF----SAGTEYMDLQNDLGQTALHLAAILGEASTVEKLYAAGAGLC VAERRGHTALHLACR-VG--AHACARALLQPRPRRPREAPDTSLAQGPDHTPDTNHTPVA LYPDSDLEKEEEESEEDWKLQLEAENYE------------------------------GH TPLHVAVIHKD---------------------------VEMVRLLRDA-GAD--LDKPEP TCGRSPLHLAVEAQAADVLELLL-RAGA--NPVARMYGGRTPLGSAMLRP----SPILAR LLRAHGAP---------------------------------------------------- -----EPEGED-DKPGPC----SSSSDS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------DSGDEGDEYDDIVVHSGRSHTRLPPTPASKPLPDDPGPV-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >H_sapiens_ENSP00000375929 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LQNSRQSPATGGRLRGAPEAAGAMAGVACLGKAAD---ADEW----- -----CDSGLGSLGPDAAAPGGPGLG---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AELGPGL-----------SWAPLVFGYVTEDGDTALHLA VIHQHEPFLDFLLGF----SAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLC VAERRGHTALHLACR-VG--AHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVA LYPDSDLEKEEEESEEDWKLQLEAENYE------------------------------GH TPLHVAVIHKD---------------------------VEMVRLLRDA-GAD--LDKPEP TCGRSPLHLAVEAQAADVLELLL-RAGA--NPAARMYGGRTPLGSAMLRP----NPILAR LLRAHGAP---------------------------------------------------- -----EPEGED-EKSGPC----SSSSDS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------DSGDEG-----------VSQEERQGSPAGGSG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >B_taurus_ENSBTAP00000002330 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MAGVACLGKAAD---ADEW----- -----CDSGLGSLGPDAAAPGGPGLG---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AELGPGL-----------SWAPLVFGYVTEDGDTALHLA VIHQHEPFLDFLLGF----AAGTEYLDLQNDLGQTALHLAAILEEASAVEKLYAAGSSLL VAERGGHTALHLACR-VG--AHTCARVLLQPRPQRPRGAPKTYLAQGSDHTPDTDHTPIA LYSEPDVEKEEDESEEDWKLQLEAEDYE------------------------------GH TPLHVAVIHKD---------------------------AEMVRLLQEA-GAD--LNKPEP TCGRSPLHLAVEAQAADVLELLL-KAGA--DPAVRMYGGRTPLGSAMLRP----NAILAR LLRAHGAP---------------------------------------------------- -----EPEDED--KPGPCSSSSSSSSDS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------ESGDEGDEYDDIVVHSGRSPNQLPPTPASKPLPDDP--I-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_nigroviridis_ENSTNIP00000016350 ----------------------------------------------IDPRLQLQMNL-MQ YDYIPRV----DIKTEPYIPETAHGPYIQIIEEP--KQRGFRFRYECEGPSHGGLPGASS EKNRRTYPTVKINN------------------------------------YVGHARVEVQ LVTH-TDPPRVHAHSLVGRH-CTENGTCTVDVGPNDLTA-SFSNLGILHVTKKSVVEVLT RRLREERRRQKGAHCHLT------------------------DS-EENSILKEAKELGKV MDLNIVRLKFTAFLQDSNGGFTRALKP-----VVSNAIYDSKSPNASN--LKISR----- -----MDKTCGTVLGGDEIFLLCDKVQK-DDI-EI-----RFYEE--DEGG---WEAFGD FSPTDVHKQYAIVFKTPPYHSAEIERPVTVFLQLKRKKAGDSSDPKQFTYIPHVQ--DKE EVLRKKQKPLP-HYEPW--------FGG-------------------------------- -----G------------------------------------------------------ -------------G-GAVTIVWCL------SGY--------------------------- ---------------------------QFN-SADD--EA--------------------- ------------------------------------------------------------ --SPVLTEG-----------------------------------------------AGTQ MSGSAPRPQRGG-HTR-----------GPNV-AAPLQRLHRIA----------------- ------------------TAL---HHS----------------------------TSQRA QQTAAGLLQYCSSGD------TRVLLAV-----------H--THLCSVQDTNGDTPLHLA VIHQQTAVVHQLVQTLLSSRQ-PGVLNTANHLLQTPLHLAVITRQVKVVELLLRAGVDPS LPDKDGRTPVHLAAS-AG--DSATLRLLLAHLG--------------------------- ---------------ESHAHVVNSPDYH------------------------------GL RPLHLAVRRDG---------------------------ERCLRLLVEG-GAK--INAPEQ KSGHTALHQAVKENLFKVACTLITELKA--DVNACTFGGNTPLHLAASQG----SPTLCS MLVAAGAD---------------------------------------------------- -----KNVEND-EPLLLS----SSSDEE-------------------------------- ------------EPEG-------------------------------------------- ------------------------------------------DAPE-------ASQPIT- ------------------------------------------------------------ ----------------------RKRPAGGHTPLDLA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------SC-QK--------VRNL LSS-------GTRP-SPVHSG-----SPGAES---ASLDEDTVSRLMDVLSD--TDVPWM KLAEKLGMKTLTQLYVDTEAPCQHLL--QH-YKLAGGPVQVLIEALQDLGLSEGVRLLRT TERQQEKHNTVQSE----------------------------ATVDSGFSSQPME--EE- EQ-----E---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >H_sapiens_ENSP00000358983 ---------------------------------MESC------------YNP-GLDGIIE YDDFKLNSSIVEPKEPA--PETADGPYLVIVEQP--KQRGFRFRYGCEGPSHGGLPGASS EKGRKTYPTVKICN------------------------------------YEGPAKIEVD LVTH-SDPPRAHAHSLVGKQ-CSELGICAVSVGPKDMTA-QFNNLGVLHVTKKNMMGTMI QKLQRQRLRSRPQG--LT------------------------EA-EQRELEQEAKELKKV MDLSIVRLRFSAFLRASDGSFSLPLKP-----VISQPIHDSKSPGASN--LKISR----- -----MDKTAGSVRGGDEVYLLCDKVQK-DDI-EV-----RFYED--DENG---WQAFGD FSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYYPLVE--DKE EVQRKRRKALP-TFSQP--------FGG-GSH-MG-------------------GGSGGA AGGYGG------------------------------------------------------ -------------A-GGGGSLGFF-----PSSL--------------------------- ---------------------------AYS-PYQSGAGP--------------------- ------------------------------------------------------------ --MGCYPGG----------G------------------------------------GGAQ MAATV--PSRDSGEEA-----------AEPS---APSRTPQCEPQ-AP------------ ------------EMLQRAREY---NAR----------------------------LFGLA QRSARALLDYGVTAD------ARALLAG-----------Q--RHLLTAQDENGDTPLHLA IIHGQTSVIEQIVYVIHHAQD-LGVVNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPA LLDRHGDSAMHLALR-AGAGAPELLRALLQSGA--------------------------- ---------------PAVPQLLHMPDFE------------------------------GL YPVHLAVRARS---------------------------PECLDLLVDS-GAE--VEATER QGGRTALHLATEMEELGLVTHLVTKLRA--NVNARTFAGNTPLHLAAGLG----YPTLTR LLLKAGAD---------------------------------------------------- -----IHAENE-EPLCPL----PSPPTS-------------------------------- ------------DSDS-------------------------------------------- ------------------------------------------DSE--------------- ------------------------------------------------------------ -----------------GPEKDTRSSFRGHTPLDLT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------CS-TK--------VKTL LL---------NAA-QNTMEPPLTPPSPAGPG---LSLGDTALQNLEQLLDGPEAQGSWA ELAERLGLRSLVDTYRQTTSPSGSLL--RS-YELAGGDLAGLLEALSDMGLEEGVRLLRG PETRDKLPSTA--E----------------------------VKEDSAYGSQSVE--QEA EKLGPPPEPPGGLCHGHPQPQVH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >R_norvegicus_ENSRNOP00000027212 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MAGVACLGKTAD---ADEW----- -----CDSGLGSLGPDAAAPGGPGLV---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AELSPEL-----------SWAPLVFGYVTEDGDTALHLA VIHQHEPFLDFLLGF----SAGTEYLDLQNDLGQTALHLAAILGEASTVEKLYAAGAGVL VTERGGHTALHLACR-VR--AHTCAYVLLQPRPSHPRDASDTYLTQSQDHTPDTSHAPVA TDPQPNPGNEEELRDEDWRLQLEAENYD------------------------------GH TPLHVAVIHKD---------------------------AEMVQLLRDA-GAD--LNKPEP TCGRTPLHLAVEGQAAGVLALLL-KAGA--DPTARMYGGRTPLGSALLRP----NPVLAR LLRAHGAP---------------------------------------------------- -----EPEDED-DKLSPC-SNSSSDSDS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------DNRDEGDEYDDIVVHSRRSQNQPPPSPAAKPLPDDPNPA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_mulatta_ENSMMUP00000003997 ---------------------------------MESC------------YNP-GLDGIIE YDDFKLNSSIMEPKEPA--PETADGPYLVIVEQP--KQRGFRFRYGCEGPSHGGLPGASS EKGRKTYPTVKICN------------------------------------YEGPAKIEVD LVTH-SDPPRAHAHSLVGKQ-CSELGICAVSVGPKDMTA-QFNNLGVLHVTKKNMMGTMI QKLQRQRLRSRPQG--LT------------------------EA-EQRELEQEAKELKKV MDLSIVRLRFSAFLRASDGSFSLPLKP-----VISQPIHDSKSPGASN--LKISR----- -----MDKTAGSVRGGDEVYLLCDKVQK-DDI-EV-----RFYED--DENG---WQAFGD FSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYYPLVE--DKE EVQRKRRKALP-TFSQP--------FGG-GSH-MG-------------------GGSGGA AGGYGG------------------------------------------------------ -------------A-GGGGSLGFF-----PSSL--------------------------- ---------------------------AYS-PYQSGAGP--------------------- ------------------------------------------------------------ --MGCYPGG----------G------------------------------------GGAQ MAASV--PGRDSGEEA-----------AEPS---APSRAPQCEPQ-AP------------ ------------EMLQRAREY---NAR----------------------------LFCLA QRSARALLDYGVTAD------ARALLAG-----------Q--RHLLTAQDENGDTPLHLA IIHGQTSVIEQIAYVIHHAQD-LGVVNLTNHLHQTPLHLAVITRQTSVVSFLLRVGADPA LLDRHGDSAMHLALR-AGAGAPELLRALLQSGA--------------------------- ---------------PAVPQLLHMPDFE------------------------------GL YPVHLAVRARS---------------------------PECLDLLVDS-GAE--VEATER QGGRTALHLATEMEELGLVTHLVTKLRA--NVNARTFAGNTPLHLAAGLG----YPTLTR LLLKAGAD---------------------------------------------------- -----IHAENE-EPLCPL----PSPPTS-------------------------------- ------------DSDS-------------------------------------------- ------------------------------------------DTE--------------- ------------------------------------------------------------ -----------------GPEKDTRSSFRGHTPLDLT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------CS-TK--------VKTL LI---------NAA-QNTMEPPLTPPSPAGPG---LSLGDTALQNLEQLLDGPEAQGSWA ELAERLGLRSLVDTYRQTASPSGSLL--RS-YELAGGDMAGLLEALSDMGLEEGVRLLRG PETRDKLPST-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >X_tropicalis_ENSXETP00000000018 ---------------------------------MMSALK-------IENFDPYSCNGIEE SNGIGYSSSLLDTRVLG--QDMANVAFLSIIEQP--KQRTGAQNICCTGLLY---LSTVL SKGNEVFRINTIFN------------------------------------YVGMARIEVD LVTH-IDPPRVHAHSLVGKH-SNETGNCVVTVGPEDMTA-QFNNLGIVHVTKKSQTEILK EKMKRQILRHTGRNL-LT------------------------EA-EERRIEQEVKELKKV TDLSIVRLRFTAYLPDSNGAYTLGLPP-----VISDPIHDSKSPGASN--LRISR----- -----MDKTAGSVKGGDEVYLLCDKVQK-DDI-EV-----RFYED--DENG---WQSFGD FAPTDVHKQYAIVFRTPPYHTQKIDRPVTVFLQLKRKKGGDVSDSKQFTYYPLEQ--DKE EVDRKRRKDLP-TFNNH-------FFGG-GSP-MG-------------------GAGGGS SFGQGG------------------------------------------------------ ---------------GGSNINYPY-----PGMQ--------------------------- ---------------------------TA--FYMSSPAG--------------------- ------------------------------------------------------------ --GGYHSSGHMMKHCSAANS------------------------------------SEKN QAPSI--NIKKEGEEA-----------SACS-QQARSTSAQKETQ-CQ------------ ------------MIMHQANLC---NMR----------------------------MLSLT QRTSRALLDYAITAD------PRMLLAV-----------Q--RHLIATQDENGDTPLHLA VIHGQPSVIEQLVQVIISIPN-QQILNMSNHLQQTPLHLGVITKQYSVVAFLLKAGADPT ILDRYGNSVLHLAVQ-AE--DDKMLSVLLKYPS--------------------------- ---------------VGQKDLLNMPDYH------------------------------GL CPVHWSVKMKN---------------------------EKCLELLVKA-GAN--VNSPER KSGKSPLHIAVEMDNLNMAIFLVKKSHA--DINAKTYGGNTPLHLAASRG----SPMLTK MLVNEGAN---------------------------------------------------- -----VLSEND-EPVNKL----PSCNSD-------------------------------- ------------TSES-------------------------------------------- ------------------------------------------DSDVQMDTDSDHHGGSDT DSSTAV----------------------------------------------------DS DCEHSAEEMHSKEQRGIRPHCAVKRRYPGHTALDLT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------KS-QK--------VRDI LS---------KHT-PGSASWKRREPEPVN---V-LALETNTVQRLEKLLNEGQTGADWT ELASRLRLQSLVETYRNTSSPTESLL--RS-YELAGGSLTELINTLQSMGLNKGVELLCK SETYAKHQSPA--E----------------------------GKNDSAYESQSMEVDQSS AELSPTTEPAIGQ----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >D_rerio_ENSDARP00000056498 ---------------------------------MAGALRMDDTHYQIGFVVNEPMTFPSA YDDLPYMPEAFEVKHEPFVQETVDGPYIQIIEEP--KQRGFRFRYECEGPSHGGLPGASS ERNRRTYPTVKVLN------------------------------------FVGNARVEVQ LVTH-TDPPRVHAHSLVGRH-CNESGVCSVDVGPSDFTA-QFSNLGILHVTKRGVVEVLT KRLKEEKRKVKGPGYKFS------------------------DA-EENALMQEAKELGKN MDLNIVRLKFTAYLQDSNGSYTRALKP-----VVSNPIYDSKSPNASN--LKISR----- -----MDKTSGSVLGGEEVFLLCDKVQK-DDI-DI-----RFYEEE-DE-----WEALGD FSPTDVHKQYAIVFKTPPYRCTNIDRPVTVFLQLKRKKGGDCSEPKQFTYVPHNQ--DKE EVQRKRMKALPDHYGGW--------RGG-PQG-GA-------------------GGFGGP GSGTGG------------------------------------------------------ -------------G-GGMG-----------GGF--------------------------- ---------------------------PFN-PMDN------------------------- ------------------------------------------------------------ --SSFFVGGCGGF------G------------------------------------GGAQ MSDSP--PQTDGANTQ-----------SQSN-SQIRQQLIQIA----------------- --------------------L---HNR----------------------------ANLAA KCNARALLQYSSTGD------ARPLLAL-----------Q--RHLCGVQDENGDTPLHLA IIHQKTVVAEQLIKALNSSPQ-QKFFNKLNKLSQAPLHLAVITKQPKLVEMLMKSGADPS LLDREGRTVLHLAAH-TG--DDVILRLVLSLLG--------------------------- ---------------EHHSHLINSADFT------------------------------GQ YPVHLAVKKDG---------------------------ERCLRLLVEA-GAK--INMPEQ KSGCTALHLAVRDNLLKLACNLITELKA--DVNACTYGGNSPLHLAASQG----SPHLCS MLIAAGAD---------------------------------------------------- -----KRIEND-EPLFLS----SSSSDE-------------------------------- ------------DEES-------------------------------------------- ------------------------------------------EKKL-------SEDMVQQ VHCLSI----------------------------------------------------SS ER---------------GVFNPRKRPAAGHTPFDLA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------KS-QK--------VRDL LDG-------RKGPKPNSLSPKRTKISTEEVN---QDLDNEVLSKLCGILIH--DDVPWR ELAEKLGMLTLTHLYQDSASPCQKLL--ES-YQV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >D_rerio_ENSDARP00000057671 ---------------------------------MAGALRMDDTHYQIGFVVNEPMTFPSA YDDLPYMPEAFEVKHEPFVQETVDGPYIQIIEEP--KQRGFRFRYECEGPSHGGLPGASS ERNRRTYPTVKVLN------------------------------------FVGNARVEVQ LVTH-TDPPRVHAHSLVGRH-CNESGVCSVDVGPSDFTA-QFSNLGILHVTKRGVVEVLT KRLKEEKRKVKGPGYKFS------------------------DA-EENALMQEAKELGKN MDLNIVRLKFTAYLQDSNGSYTRALKP-----VVSNPIYDSKSPNASN--LKISR----- -----MDKTSGSVLGGEEVFLLCDKVQK-DDI-DI-----RFYEEE-DE-----WEALGD FSPTDVHKQYAIVFKTPPYRCTNIDRPVTVFLQLKRKKGGDCSEPKQFTYVPHNQ--DKE EVQRKRMKALPDHYGGW--------RGG-PQG-GA-------------------GGFGGP GSGTGG------------------------------------------------------ -------------G-GGMG-----------GGF--------------------------- ---------------------------PFN-PMDN------------------------- ------------------------------------------------------------ --SSFFVGGCGGF------G------------------------------------GGAQ MSDSP--PQTDGANTQ-----------SQSN-SQIRQQLIQIA----------------- --------------------L---HNR----------------------------ANLAA KCNARALLQYSSTGD------ARPLLAL-----------Q--RHLCGVQDENGDTPLHLA IIHQKTVVAEQLIKALNSSPQ-QKFFNKLNKLSQAPLHLAVITKQPKLVEMLMKSGADPS LLDREGRTVLHLAAH-TG--DDVILRLVLSLLG--------------------------- ---------------EHHSHLINSADFT------------------------------GQ YPVHLAVKKDG---------------------------ERCLRLLVEA-GAK--INMPEQ KSGCTALHLAVRDNLLKLACNLITELKA--DVNACTYGGNSPLHLAASQG----SPHLCS MLIAAGAD---------------------------------------------------- -----KRIEND-EPLFLS----SSSSDE-------------------------------- ------------DEES-------------------------------------------- ------------------------------------------EKKL-------SEDMVQQ VHCLSI----------------------------------------------------SS ER---------------GVFNPRKRPAAGHTPFDLA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------KS-QK--------VRDL LDG-------RKGPKPNSLSPKRTKISTEEVN---QDLDNEVLSKLCGILIH--DDVPWR ELAEKLGMLTLTHLYQDSASPCQKLL--ES-YQLSGGPVDGLVEALQALGVREGVRLLRD SQPREDKQSSV--D----------------------------STEDSGFGSQSIG--EEM ANPAVGNH---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_musculus_ENSMUSP00000072859 ---------------------------------MDNC------------YDP-GLDGIPE YDDFEFSPSIVEPKDPA--PETADGPYLVIVEQP--KQRGFRFRYGCEGPSHGGLPGASS EKGRKTYPTVKICN------------------------------------YEGPAKIEVD LVTH-SDPPRAHAHSLVGKQ-CSELGVCAVSVGPKDMTA-QFNNLGVLHVTKKNMMEIMI QKLQRQRLRSKPQG--LT------------------------EA-ERRELEQEAKELKKV MDLSIVRLRFSAFLRASDGSFSLPLKP-----VISQPIHDSKSPGASN--LKISR----- -----MDKTAGSVRGGDEVYLLCDKVQK-DDI-EV-----RFYED--DENG---WQAFGD FSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYYPLVE--DKE EVQRKRRKALP-TFSQP--------FGG-GSH-MG-------------------GGSGGS AGGYGG------------------------------------------------------ -------------A-GGGGSLGFF-----SSSL--------------------------- ---------------------------AYN-PYQSGAAP--------------------- ------------------------------------------------------------ --MGCYPGG----------G------------------------------------GGAQ MAGSR--RDTDAGEGA-----------EEPR---TPPEAPQGEPQ-AL------------ ------------DTLQRAREY---NAR----------------------------LFGLA QRSARALLDYGVTAD------ARALLAG-----------Q--RHLLMAQDENGDTPLHLA IIHGQTGVIEQIAHVIYHAQY-LGVINLTNHLHQTPLHLAVITGQTRVVSFLLQVGADPT LLDRHGDSALHLALR-AGAAAPELLQALLRSGA--------------------------- ---------------HAVPQILHMPDFE------------------------------GL YPVHLAVHARS---------------------------PECLDLLVDC-GAE--VEAPER QGGRTALHLATEMEELGLVTHLVTKLHA--NVNARTFAGNTPLHLAAGLG----SPTLTR LLLKAGAD---------------------------------------------------- -----IHAENE-EPLCPL----PSPSTS-------------------------------- ------------GSDS-------------------------------------------- ------------------------------------------DSE--------------- ------------------------------------------------------------ -----------------GPERDTQRNFRGHTPLDLT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------CS-TK--------VKTL LL---------NAA-QNTTEPPLAPPSPAGPG---LSLGDAALQNLEQLLDGPEAQGSWA ELAERLGLRSLVDTYRKTPSPSGSLL--RS-YKLAGGDLVGLLEALSDMGLHEGVRLLKG PETRDKLPST---E----------------------------VKEDSAYGSQSVE--QEA EKLCPPPEPPGGLCHGHPQPQVH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >E_caballus_ENSECAP00000017595 ---------------------------------MESC------------YDP-GLDGIID YDDFKFNPSIVEPKEPA--PETADGPYLVIVEQP--KQRGFRFRYGCEGPSHGGLPGASS EKGRKTYPTVKICN------------------------------------YEGPAKIEVD LVTH-SDPPRAHAHSLVGKQ-CSELGVCAVSVGPKDMTA-QFNNLGVLHVTKKNMMEIMI QKLQRQRLRSRPQG--LT------------------------ET-ERRELEQEAKELKKV MDLSIVRLRFSAFLRASDGSFSLPLKP-----VISQPIHDSKSPGASN--LKISR----- -----MDKTAGSVRGGDEVYLLCDKVQK-DDI-EV-----RFYED--DENG---WQAFGD FSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYYPLVE--DKE EVQRKRRKALP-TFSQH--------FGG-GSH-MG-------------------GGSGGS AGGYGG------------------------------------------------------ -------------AGGGGGSLGFF------SSL--------------------------- ---------------------------TYN-P-QSGAAP--------------------- ------------------------------------------------------------ --MGCYPGG----------G------------------------------------GGAQ MAAGA--PSVDAGEEA-----------AEPS---ASPVIPQHEPQ-AP------------ ------------ELLQQAREY---NER----------------------------LFGLA RRSARALLDYGVTAD------ARALLAG-----------Q--RHLLTAQDENGDTPLHLA IIHGQTSVIEQIAHVIYHAQH-LGVVNLTNHLHQTPLHLAVITGQTRVVSFLLQVGADPA LLDRHGDSAVHLALR-VGAGAPDLLRALLQSGV--------------------------- ---------------PAMPQLLHLPDFE------------------------------GL YPVHLAVRARS---------------------------PECLDLLVDN-GAE--VEAAER QGGRTALHLATEMEELGLVTHLVTKLRA--NVNARTFAGNTPLHLAAGLG----SPTLTR LLLKAGAD---------------------------------------------------- -----IHAENE-EPLCPL----PSPPTS-------------------------------- ------------DSDS-------------------------------------------- ------------------------------------------DSE--------------- ------------------------------------------------------------ -----------------GPERDIRSSFRGHTPLDLT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------RS-SK--------VKTL LL---------NAA-QDTMAPPLTPPSPAGPE---LPLEDTVLQNLEHLLDGPGAQGSWA ELAERLGLRSLVDTYRKTASPSGSLL--RS-YKLAGGDLAGLLDALSDMGLEEGVRLLRG PEARDKLPST---E----------------------------AKEDSAYGSQSVE--QEA EKLGPPPEPPGGLCHGHPQPQVH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_familiaris_ENSCAFP00000014918 ---------------------------------MESC------------YDP-GLDGMIE YDDFKFDPCIAEPKEPA--PETADGPYLVIVEQP--KQRGFRFRYGCEGPSHGGLPGASS EKGRKTYPTVKICN------------------------------------YEGPAKIEVD LVTH-SDPPRAHAHSLVGKQ-CSELGVCAVSVGPKDMTA-QFNNLGVLHVTKKNMMEIMI QKLQRQRLRSRPQG--LT------------------------EA-ERRELEQEAKELKKV MDLSIVRLRFSAFLRASDGSFSLPLKP-----VISQPIHDSKSPGASN--LKISR----- -----MDKTAGSVRGGDEVYLLCDKVQK-DDI-EV-----RFYED--DENG---WQAFGD FSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYYPRAA--DKE EVQRKRRKALP-TFSQH--------FGG-GSHKIR-------------------ESPGWC LLPTAR------------------------------------------------------ -------------PVSAGGSLGFF------PSL--------------------------- ---------------------------AYS-PYPTGSAP--------------------- ------------------------------------------------------------ --LGCYPGG----------G------------------------------------GGAQ MAAGA--PGVDAGEEA-----------AEPS---ASPLTPQREPQ-AP------------ ------------ELLQRAREY---NAR----------------------------LFGLA QRSARALLDYGVTAD------ARALLAG-----------Q--RHLLTAQDENGDTPLHLA IIHGQTSVIEQIAHVIYHARH-LGVVNLTNHLHQTPLHLAVITGQTSVVSFLLQVGADPA LLDRHGDSAVHLALR-AGTSAPDLLRALLRSGV--------------------------- ---------------PTMPQLLHMPDFE------------------------------GL YPVHLAVRARS---------------------------PECLDLLVDS-GAE--VEAAER QGGRTALHLATEMEELGLVTHLVTKLRA--NVNARTFAGNTPLHLAAGLG----SPTLTR LLLKAGAD---------------------------------------------------- -----IHAENE-EPLCPL----PSPPTS-------------------------------- ------------GSDS-------------------------------------------- ------------------------------------------DSE--------------- ------------------------------------------------------------ -----------------GPERDARGSSRGHTPLDLT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------RS-TK--------VKTL LL---------NAA-QDTMAPPLTPPSPAGPD---LPLEDAVLQNLEHLLDGPGAQGSWA ELAERLGLRSLVDTYRKTASPSGSLL--RS-YKLAGGDLAGLLCALSDMGLEEGVRLLRG PEARDKLPSTA--E----------------------------VKEDSAYGSQSVE--QEA EKLGSPPEPPGGLCHGHPQPQVH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >B_taurus_ENSBTAP00000007904 ---------------------------------MDSC------------YDP-GLDGIIE YDDFKFNPSIVEPKEPA--PETADGPYLVIVEQP--KQRGFRFRYGCEGPSHGGLPGASS EKGRKTYPTVKICN------------------------------------YEGPAKIEVD LVTH-SDPPRAHAHSLVGKQ-CSELGVCAVSVGPKDMTA-QFNNLGVLHVTKKNMMEIMI QKLQRQRLRSRPQG--LT------------------------EA-ERRELEQEAKELKKV MDLSIVRLRFSAFLRASDGSFSLPLKP-----VISQPIHDSKSPGASN--LKISR----- -----MDKTAGSVRGGDEVYLLCDKVQK-DDI-EV-----RFYED--DENG---WQAFGD FSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYYPLVE--DKE EVQRKRRKALP-TFSQP--------FGG-GSH-MG-------------------GGSGGS AGGYGG------------------------------------------------------ -------------AGGGGGSLGFF-----PSSL--------------------------- ---------------------------AYS-PYQSGAAP--------------------- ------------------------------------------------------------ --MGCYPGG----------G------------------------------------GGAQ MAAET--PSVDAGEEA-----------AEPS---APPGTPQREQQ-TP------------ ------------ELLHRAREY---NAR----------------------------LFGLA QRSARALLDYGVTAD------ARSLLAG-----------Q--RHLLTAQDENGDTPLHLA IIHGQTTVIEQIAHVIYHAPH-LGVVNITNHLHQTPLHLAVITGQTKVVSFLLQVGADPA LLDRHGDSAVHLALR-AGASAPDMLCALLRSGV--------------------------- ---------------PAMPQLLHVPDFE------------------------------GL YPVHLAVRARS---------------------------PECLDLLVES-GAE--VEAAER QGGRTALHLATEMEELGLVTHLVTKLRA--NVNARTFAGNTPLHLAAGLG----SPTLTR LLLKAGAD---------------------------------------------------- -----VHAENE-EPLCPL----PSPPTS-------------------------------- ------------GSDS-------------------------------------------- ------------------------------------------DSE--------------- ------------------------------------------------------------ -----------------SPERDTRGSFRGHTPLDLT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------RS-SK--------VKTL LL---------NAA-QDTMAPPLTPPSPAGPE---IPLEDTVLQNLEHLLDGPGAQGSWV ELAERLGLRSLVDTYRRTASPSGSLL--RS-YQLAGGDWTGLLNALSDMGLEEGVRLLKG PETQEKLPST---E----------------------------VKEDSAYGSQSVE--QET EKLGPPPEPPGGLCHGRPQPQVH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_mulatta_ENSMMUP00000018114 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MDEGPVDLRTRPKAAGL-PG AALPLRKRPLRAPSPEPAAPRGAAGLV----VPLDPLRGGCDLPAVPGPPHGLAR----- ------------------------------------------------------------ --PEALYYPGALLP---LYPTRTMGSPFPL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --VNLPTPLYPMMCP------MEHPLSA-----------D--IAMATRADEDGDTPLHIA VVQGNLPAVHRLVNL---FQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPM ALDRHGQTAAHLACE-HR--SPTCLRALLDSAV--------------------------- ----------------PGTLDLEARNYD------------------------------GL TALHVAVNTEC---------------------------QETVQLLLER-GAD--IDAVDI KSGRSPLIHAVENNSLSMVQLLL-QHGA--NVNAQMYSGSSALHSASGRG----LLPLVR TLVRSGAD---------------------------------------------------- -----SSLKNC-HNDTPL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MVA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------RS-----------RRV- --SRGGCGHA--------PCTRVPQPLLSGSSLSPPSPSVSLPSSGLLSASP-SSSPSQS PPKDPPGFPMAPPNFFLPSPSPPAFLPFAGVLRGPGRPVPSSPAPGGS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >H_sapiens_ENSP00000384024 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MPRCPAGAMDEGPVDLRTRPKAAGL-PG AALPLRKRPLRAPSPEPAAPRGAAGLV----VPLDPLRGGCDLPAVPGPPHGLAR----- ------------------------------------------------------------ --PEALYYPGALLP---LYPTRAMGSPFPL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --VNLPTPLYPMMCP------MEHPLSA-----------D--IAMATRADEDGDTPLHIA VVQGNLPAVHRLVNL---FQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPM ALDRHGQTAAHLACE-HR--SPTCLRALLDSAA--------------------------- ----------------PGTLDLEARNYD------------------------------GL TALHVAVNTEC---------------------------QETVQLLLER-GAD--IDAVDI KSGRSPLIHAVENNSLSMVQLLL-QHGA--NVNAQMYSGSSALHSASGRG----LLPLVR TLVRSGAD---------------------------------------------------- -----SSLKNC-HNDTPL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MVA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------RS-----------RRVI DILRGKATRP--------ASTSQPDPSPDRSANTSPESSSRLSSNGLLSASP-SSSPSQS PPRDPPGFPMAPPNFFLPSPSPPAFLPFAGVLRGPGRPVPPSPAPGGS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_troglodytes_ENSPTRP00000048640 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MPRCPAGAMDEGPVDLRTRPKAAGL-PG AALPLRKRPLRAPSPEPAAPRGAAGLV----VPLDPLRGGCDLPAVPGPPHGLAR----- ------------------------------------------------------------ --PEALYYPGALLP---LYPTRAMGSPFPL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --VNLPTPLYPMMCP------MEHPLSA-----------D--IAMATRADEDGDTPLHIA VVQGNLPAVHRLVNL---FQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPM ALDRHGQTAAHLACE-HR--SPTCLRALLDSAA--------------------------- ----------------PGTLDLEARNYD------------------------------GL TALHVAVNTEC---------------------------QETVQLLLER-GAD--IDAVDI KSGRSPLIHAVENNSLSMVQLLL-QHGA--NVNAQMYSGSSALHSASGRG----LLPLVR TLVRSGAD---------------------------------------------------- -----SSLKNC-HNDTPL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MVA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------RS-----------RRVI DILRGKATRP--------ASTSQPDPSPDRSANTSPESSSRLSSNGLLSTSP-SSSPSQS PPRDPPGFPMAPPNFFLPSPSPPTFLPFAGVLRGPGRPVPPSPAPGGS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_pygmaeus_ENSPPYP00000011294 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MDEGPVDLRTRPKAAGL-PG AALPLRKRPLRAPSPEPAAPRGAAGLV----VPLDPLRGGCDLPAAPGPPHGLAR----- ------------------------------------------------------------ --PXALYYPGPLLP---LYPTRTMGSPFPL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --VNLPTPLYPMMCP------MEHPLSA-----------D--IAMATRADEDGDTPLHIA VVQGNLPAVHRLVNL---FQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPM ALDRHGQTAAHLACE-HR--SPTCLRALLDSAA--------------------------- ----------------PGTLDLEARNYD------------------------------GL TALHVAVNTEC---------------------------QETVQLLLER-GAD--IDAVDI KSGRSPLIHAVENNSLSMVQLLL-QHGA--NVNAQMYSGSSALHSASGRG----LLPLVR TLVRSGAD---------------------------------------------------- -----SSLKNC-HNDTPL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MVA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------RS-----------RRVI DILRGKATRP--------ASTSQPDPSPDRSANTSPESSSRLSSNGLLSASP-SSSPSQS PPKDPPGFPMAPPNFFLPSPSPPAFLPFAGVLRGPGRPVPPSPAPGGS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >B_taurus_ENSBTAP00000012490 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MDEGPVDLRTRPKATGP-PG AALPLRKRPLRAPSPEPAAPRVAAGPV----VPPDPLRGGSDTPAVLAPPHGLAR----- ------------------------------------------------------------ --PEAIYYQGPLLS---LYPTPTMGPPFPL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --LNLPTPLYPMVCS------MEHPLSA-----------D--FAMATRADEDGDTPLHIA VVQGNLPAVHRLVNL---FQHGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVMAGASPM ALDRHGQTAAHLACE-HR--SPACLRALLDSAP--------------------------- ----------------GGTMDLEARNYD------------------------------GL TALHVAVNTEC---------------------------QEAVLLLLEH-GAD--IDAVDI KSGRSPLIHAVENNSLSMVQLLL-QHGA--NVNAQMYSGSSALHSASGRG----LLPLVR TLVRSGAD---------------------------------------------------- -----SGLKNC-HNDTPL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MVA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------RS-----------RRVI DILRGKATRP--------APASQPEPSPDRSTTTSPESSSRLSSNGLLSASP-PSSPSQS PPKDPSGFPMAPPSFFLPPSSPPTFLPYAGVLRAPGRPVPPSPAPGGS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >R_norvegicus_ENSRNOP00000026235 ---------------------------------MDRC------------YDP-GLDGIPE YDDFEFSPSIVEPKDPA--PETADGPYLVIVEQP--KQRGFRFRYGCEGPSHGGLPGASS EKGRKTYPTVKICN------------------------------------YEGPAKIEVD LVTH-SDPPRAHAHSLVGKQ-CSELGVCAVSVGPKDMTA-QFNNLGVLHVTKKNMMEIMI QKLQRQRLRSKPQG--LT------------------------EA-ERRELEQEAKELKKV MDLSIVRLRFSAFLRASDGSFSLPLKP-----VISQPIHDSKSPGASN--LKISR----- -----MDKTAGSVRGGDEVYLLCDKVQK-DDI-EV-----RFYED--DENG---WQAFGD FSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYYPLVE--DKE EVQRKRRKALP-TFSQP--------FGG-GSH-MG-------------------GGSGGS AGGYGG------------------------------------------------------ -------------A-GGGGSLGFF------SSF--------------------------- ---------------------------AYS-PYQSGAAP--------------------- ------------------------------------------------------------ --MGCFPGG----------G------------------------------------GGAQ MAGSG--RDAEAGEAE-----------EQPR---APSEAPQSEQQ-AL------------ ------------DTLQRAREY---NAR----------------------------LFGLA QRSARALLDYGVTAD------ARALLAG-----------Q--RHLLMAQDENGDTPLHLA IIHGQTGVIEQIAQVIYHAQY-LGVINLTNHLHQTPLHLAVITGQTRVVSFLLQVGADPT LLDRHGDSAVHLALR-AGAAAPDLLQAVLHSGA--------------------------- ---------------HALPQMLHMPDFE------------------------------GL YPVHLAVHARS---------------------------PECLDLLVDC-GAE--VEAAER QGGRTPLHLATEMEELGLVTHLVTKLHA--NVNARTFAGNTPLHLAAGLG----SPTLTR LLLKAGAD---------------------------------------------------- -----IHAENE-EPLCPL----PSPPTS-------------------------------- ------------GSDS-------------------------------------------- ------------------------------------------DSE--------------- ------------------------------------------------------------ -----------------GPETDTQRNFRGHTPLDLT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------RS-TK--------VKTL LL---------NAA-QNTTEPPLAPPSPAGPG---LSLGDAALQNLEQLLDGPEAQGSWA ELAERLGLRSLVDTYRKTPSPSGSLL--RS-YKLAGGDLVGLLEALSDMGLHEGVRLLKA PETRDKLPST---E----------------------------VKEDSAYGSQSVE--QEA EKLCPPPEPPGGLCHGHPQPQVH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_troglodytes_ENSPTRP00000005089 ---------------------------------MESC------------YNP-GLDGIIE YDDFKLNSSIVEPKEPA--PETADGPYLVIVEQP--KQRGFRFRYGCEGPSHGGLPGASS EKGRKTYPTVKICN------------------------------------YEGPAKIEVD LVTH-SDPPRAHAHSLVGKQ-CSELGICAVSVGPKDMTA-QFNNLGVLHVTKKNMMGTMI QKLQRQRLRSRPQG--LT------------------------EA-EQRELEQEAKELKKV MDLSIVRLRFSAFLRASDGSFSLPLKP-----VISQPIHDSKSPGASN--LKISR----- -----MDKTAGSVRGGDEVYLLCDKVQK-DDI-EV-----RFYED--DENG---WQAFGD FSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYYPLVE--DKE EVQRKRRKALP-TFSQP--------FGG-GSH-MG-------------------GGSGGA AGGYGG------------------------------------------------------ -------------A-GGGGSLGFF-----PSSL--------------------------- ---------------------------AYS-PYQSGAGP--------------------- ------------------------------------------------------------ --MGCYPGG----------G------------------------------------GGAQ MAATV--PSRDSGEEA-----------AEPS---APSRTPQCEPQ-AP------------ ------------EMLQRAREY---NAR----------------------------LFGLA QRSARALLDYGVTAD------ARALLAG-----------Q--RHLLTAQDENGDTPLHLA IIHGQTSVIEQIVYVIHHAQD-LGVVNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPA LLDRHGDSAMHLALR-AGAGAPELLRALLQSGA--------------------------- ---------------PSVPQLLHMPDFE------------------------------GL YPVHLAVRARS---------------------------PECLDLLVDS-GAE--VEATER QGGRTALHLATEMEELGLVTHLVTK----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_pygmaeus_ENSPPYP00000003023 ---------------------------------MESC------------YNP-GLDGIIE YDDFKLNSSIVEHKEPA--PETADGPYLVIVEQP--KQRGFRFRYGCEGPSHGGLPGASS EKGRKTYPTVKICN------------------------------------YEGPAKIEVD LVTH-SDPPRAHAHSLVGKQ-CSELGICAVSVGPKDMTA-QFNNLGVLHVTKKNMMGTMI QKLQRQLLRSRPQG--LT------------------------EA-EQRELEQEAKELKKV MDLSIVRLRFSAFLRASDGSFSLPLKP-----VISQPIHDSKSPGASN--LKISR----- -----MDKTAGSVRGGDEVYLLCDKVQK-DDI-EV-----RFYED--DENG---WQAFGD FSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYYPLVE--DKE EVQRKRRKALP-TFSQP--------FGG-GSH-MG-------------------GGSGGA AGGYGG------------------------------------------------------ -------------A-GGGGSLGFF-----PSSL--------------------------- ---------------------------AYS-PYQSGAGP--------------------- ------------------------------------------------------------ --MGCYPGG----------G------------------------------------GGAQ MAATV--PSRDSGEEA-----------AEPS---APSRTPQCEPQ-AP------------ ------------EMLQRAREY---NAR----------------------------LFGLA QRSARALLDYGVTAD------ARALLAG-----------Q--RHLLTAQDENGDTPLHLA IIHGQTSVIEQIAYVIHHAQD-LGVVNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPA LLDRHGDSAMHLALR-AGAGAPELLRALLQSGA--------------------------- ---------------PAVPQLLHMPDFE------------------------------GL YPVHLAVRARS---------------------------PECLDLLVDS-GAE--VEATER QGGRTALHLATEMEELGLVTHLVTK----------------------------------- ---KGGAD---------------------------------------------------- -----IHAENE-EPLCPL----PSPPTS-------------------------------- ------------DSDS-------------------------------------------- ------------------------------------------DSE--------------- ------------------------------------------------------------ -----------------GPEKDTRSSFRGHTPLDLT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------CS-TK--------VKTL LL---------NAA-QNTMEPPLTPPSPAGPG---LSLGDTALQNLEQLLDGPEAQGSWA ELAERLGLRSLVDTYRQTASPSGSLL--RS-YELAGGDLAGLLEALSDMGLEEGVRLLRG PETRDKLPSTA--E----------------------------VKEDSAYGSQSVE--QEA EKLGPPPEPPGGLCHGHPQPQVH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_domestica_ENSMODP00000026087 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MDEGPVDLRTRPKAGLPDPE ATLPLRKRRYREPPRDLPQEP-----------PEPSAQSFGTYPGLPSP----------- ------------------------------------------------------------ --ATAIYYPGEALPSPFLYPAPALGAPFPV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --LGLPPPSYPVLCP------LENPLSA-----------D--IAKATRPDEDGDTPLHIA VVQGNFLAVQRLVQL---FQQGGRDLDVYNNLRQTPLHLAIITTQPSVVRLLVSRGASPM ALDRNGQTAAHLACE-HR--SPSCLRALLDTSA--------------------------- ----------------PGALGLEARNYE------------------------------GL TPLHVAVNTEN---------------------------TETVLLLLER-GAD--IDAVDI KSGRSPLIHAVENNSLCMVQLLL-QHGA--NVNAQMYSGSSALHSASGRG----LLPLVR TLVRSGAD---------------------------------------------------- -----SSLKNC-HNDTPL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MVA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------RN-----------RRVI DILRGKASRS-----GPQPALGPAEPTQDGSAPISPEGSSQFGSSGPPSASPASSSPPRS PPEDPPTSLQGPQIFFLPTQSPAAFLPYPGPLRVSGRPVPPAPAPSGS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_rubripes_ENSTRUP00000010369 ---------------------------------FWTDGFHLRPERSVLHKLPSSLTL-LI WNSWGFS----YTWPLP----GTHGPYIQIIEEP--KQRGFRFRYECEGPSHGGLPGASS EKNRRTYPTVKISN------------------------------------YVGHARVEVQ LVTH-TDPPRVHAHSLVGRH-CTENGTCMVDVGPNDLTA-SFSNLGILHVTKKSVVEVLN KRLREERRRQKAAHCLLTDVLTYLIS--------LGSPRRHPSDLEESSILKEAKELGKV MDLNIVRLKFTAYLQDSNGGFTRALKP-----VVSNAIYDSKSPNASN--LKISR----- -----MDKTCGTVLGGDEIFLLCDKVQK-DDI-EI-----RFYEE--DEGG---WEAFGD FSPTDVHKQYAIVFKTPPYHSAEIERPVTVFLQLKRKKAGDSSDPKQFTYIPHVQ--DKE EVLRKKQKPLP-HYESW--------RGG-AGG-GA--------------------GFGGG GGGGGG------------------------------------------------------ -------------G-GGGGGGFGG------GGY--------------------------- ---------------------------QFN-QQMN--GG--------------------- ------------------------------------------------------------ --GGVFFPGFTGFNG----G------------------------------------GGAQ MSCSAPPSQRVG-QPR-----------GQSAAAPLQHQLFQIGET-VV------------ ------------MTTRHGVLC---IHA----------------------------VSQSA RQTAAALLQYCSTGD------ARVLLAV-----------Q--RHLCGVQDTNGDTPLHLA IIHQQTGVIQQLIQTLLSSQQ-QNILNTANHLLQTPLHLAVITRQVKVVEMLLRAGVDPS LLDKDGRSPVHLASL-AG--DSAVLRLLLAHLK--------------------------- ---------------ASWVF-----PGS------------------------------GL HPLHLAVRRDG---------------------------ERCLRLLVEG-GAK--INAPEQ KSGNTALHLAVRENLFKVACTLITELKA--EVNACSFGGNTPLHLAASLG----SPTLCS MLVAAGAD---------------------------------------------------- -----KNMEND-EPLVCS----SSSDED-------------------------------- ------------EPDG-------------------------------------------- ------------------------------------------E----------TRQAVT- ------------------------------------------------------------ ----------------------RKR---GHTPLDLA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------NC-QK--------VRNL LNS-------RNSPKSNCSSS-----VAGAES---TSLDEDTVTQLMDVLSD--TDVPWM RLAEKLGMKTLSQLYVDSKAPCLHLL--QH-YKLAGGPVQVLIEALQDLGLSEGVRLLR- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_gorilla_ENSGGOP00000006827 ---------------------------------MESC------------YNP-GLDGIIE YDDFKLNSSIVEPKEPA--PETADGPYLVIVEQP--KQRGFRFRYGCEGPSHGGLPGASS EKGRKTYPTVKICN------------------------------------YEGPAKIEVD LVTH-SDPPRAHAHSLVGKQ-CSELGICAVSVGPKDMTA-QFNNLGVLHVTKKNMMGTMI QKLQRQRLRSRPQG--L-------------------------KA-EQRELEQEAKELKKV MDLSIVRLRFSAFLRASDGSFSLPLKP-----VISQPIHDSKSPGASN--LKISR----- -----MDKTAGSVRGGDEVYLLCDKVQK-DDI-EV-----RFYED--DENG---WQAFGD FSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYYPLVE--DKE EVQRKRRKALP-TFSQP--------FGG-GSH-MG-------------------GGSGGA AGGYGG------------------------------------------------------ -------------A-GGGGSLGFF-----PSSL--------------------------- ---------------------------AYS-PYQSGAGP--------------------- ------------------------------------------------------------ --MGCYPGG----------G------------------------------------GGAQ MAATV--PSRDSGEEA-----------AEPS---APSRTPQCEPQ-AP------------ ------------EMLQRAREY---NAR----------------------------LFGLA QRSARALLDYGVTAD------ARALLAG-----------Q--RHLLTAQDENGDTPLHLA IIHGQTSVIEQIVYVIHHAQD-LGVVNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPA LLDRHGDSAMHLALR-AGAGAXELLXALLXSGA--------------------------- ---------------PAVPQLLXMPDFE------------------------------GL YPVHLAVRARS---------------------------PECLDLLVDS-GAE--VEATER QGGRTALHLATEMEELGLVTHLVTKXXX--XXXXXXXXXXXXXXXXXXXX----XXXXXX XXXXXXAD---------------------------------------------------- -----IHAENE-EPLCPL----PSPPTS-------------------------------- ------------DSDS-------------------------------------------- ------------------------------------------DSE--------------- ------------------------------------------------------------ -----------------GPEKDTRSSFRGHTPLDLT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------CS-TK--------VKTL LL---------NAA-QNTTEPPLTPPSPAXXX---XXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXSPSGSLL--RS-YELAGGDLAGLLEALSDMGLEEGVRLLRG PETXDKLPSTA--E----------------------------VKEDSAYGSXSVE--QEA EKLGPPPEPPGGLCHGXPQPQVH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_carolinensis_ENSACAP00000009330 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QTPLHLAVITGQPALAKLLLTHGASPM VLDRHGQTALHLACE-HG--SLRCLRELLEGSL--------------------------- -----------------APLDLEARNFE------------------------------GL TPLHVAVGTSD---------------------------HNMVLALLEH-GAD--VDAVDI KSGRSPLLHAVENNNLEMVELLL-KHSA--NVNAQSYGGNTALHAASGRG----LLDTLR LLVRNGAD---------------------------------------------------- -----GSLKNY-HNDTPL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MVA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------KN-----------KRVI DILRGKASRS-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >X_tropicalis_ENSXETP00000032395 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MSDYWDEKKLPAQPEEGRYDSGVG DSVQSLSDPAVGHLQSLPEE--------------RGAEEPAPSGDKLQEPQELDR----- -----LDSLYGSSSLT-ELLPET-------------SLPKSDSEG--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------PDTPDSQ-----------Q--LECLTYVSEEGDTFLHLT VIHGWTDTALCFISL-----APADVLSIQNDLYQTGLHLATYLGQLEVVEALVSKGVNLE LQDRKGDTALHVACK-NQ--NLACAKALLQG----------------------------- ---------------PNGPQNLQLQNWK------------------------------GN WPTLVLYLKNC---------------------------VSPPTPLS---PAH--LPLQEG TSGKTPLHLAVEMLDGALLTHLL-QQRP--EVDSLMYNGCTPLHLAVGRK----DAGLAR LLCQAGAD---------------------------------------------------- -----TLRRNR-EGDTPQ----DLAEGN-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------NQLLALLPFDD-LKISGRPIVTTA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_intestinalis_ENSCINP00000019996 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------NKHDLTPK------ETLFIAT-----------E--CHLASLQDNDGDTPLHIS IVRHDTQKSLELIRL---FQISRKNIDILNRLMQTPLHLAVITSQCEVVDGLLNCAANPN VLDRFGCNVAHIAAK-YN--SLTCLQSVFKY----------------------------- ---------------SKFPLDIEKINLE------------------------------GV TALHVAVQNNS---------------------------INVLKQLLQH-GAN--IDVKDN KSGRSALIYAIESDNVIIVELLL-EQGA--SVCEQTYSGDTALHIASGRA----VQSIIR LLLRKGAD---------------------------------------------------- -----ATNRNL-PNEDLH----FFSPDSQLQTLQMIQAGMTNGDKQNAQLMRSMSCPTTP SEPKSMSHKSIMGKHQ-----------------------LENENQDESEISIKRNRLEVL KKEMNSQILGSSGSTISTNKTELNEDSTTDKRS---------IFPCIKPFGFSSYSSILP PPPPILSSGRAAYLPPQFYKEELFRKCIQDRNVMKTSVSPFLIIPKQEKDVSPTTSEAPI PSPTSTCNEYKIENCQSDVRGQIIPKQEGKTSPALT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------KPTLPIMTQYRR QAERSMSLPGSPNPSDEALFQVAREGLAVAAMPSLSTSNSLDFITQANTVPSKIRPARQA EIKSKTNELQKLALQGLAVAAMKEMKHEIVEKSRGTEYNEIYRRPLEHFISKDGRKSSTS FGIPSQLQGTARQSPIEPSLLLLAQASVVQPADDASSKREDHQISVETKQSLREVILEKK KSMEPKIPVSYTTVQTASNQTHISVEIVRPNIPTSLETNVKTENTEDVTVPLQQNESLKS ASSETSATDDSLQDIRQRLVQLNYEIQHLLSPSSDRPNPADTQQRMSTYSAEYARLCQKA KELSKNTMVSAEPVETSAAYSPQKPVNPLYPVASIRPVHQTVFPHSPQLVLHPQLMSPQL PMPLHYPYMVPNYSVMPGKHYPSPMYYLDYRRQVPTMPTTHLWQNPVTSVPQKSAVVATV KVLNTHAKKSFKPGQPSSETDE-AKLIKPVHQVPNFPQESYALPQSSQTVSMTTAHTTTT SILHKKPMAAVIAIPKLEVGEDQPLNLSKKEEQPLNLQTSGWNSRMTHTLSTPSAVESAS SKMQSYYK---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_familiaris_ENSCAFP00000006932 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MDEGPVDLRTRPKAAGP-PG AALPLRKRPLREPSPEPAAPRGAAGPV----VGPDPLGGGPDSPAVPAAPHGLAR----- ------------------------------------------------------------ --PEALYYQGPLLP---IYPTPNMGSLFPL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --LNLPTPLYSMVYS------MEHPLSA-----------D--IAVATHADEDGDTPLHIA VVQGNLPAVHRLVNL---FQHGGRELDIYNNLRQTPLHLAVITTLPSMVRLLVMAGASPM ALDRHGQTAAHLACE-HR--SPTCLRALLDSAA--------------------------- ----------------PGTVDLEARNYD------------------------------GL TALHVAVNMQC---------------------------PEAVLLLLER-GAD--IDAVDI KSGRSPLIHAVENNSLSMVQLLL-QVG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_guttata_ENSTGUP00000010673 MSSS-------------------------------------------------------- ----------------------------------------RNNRVMVKGVGARVVRG--- --PDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDLRILDSAPTGIK HDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLES RRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDN GAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLE IVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANVVRS GDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDS DLKVEVCGT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SWTYNPAAVSKVASA----GSAI-SNASG--ERLSQLLK KLFETQESGDLNEELVKAAANGDVAKVEDLLKRP-------------------DVDVNGQ CAGHTAMQAASQNGH------VDILKLL-----------LKQNVDVEAEDKDGDRAVHHA AFGDEGAVIEVLHRG-------SADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS LQDSEGDTPLHDAIS-KK--RDDILAVLLEAGA--------------------------- --------------------DVTITNNN------------------------------GF NALHHAALRGN---------------------------PSAMRVLLSK-LPRPWI-DEKK DDGYTALHLAALNNHVEVAELLVHQGNA--NLDIQNVNQQTALHLAVERQ----HTQIVR LLVRAGAK---------------------------------------------------- -----LDIQDK-DGDTPL----HEALRHHTLSQLRQLQDMQDVGK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------VDTAWEPSKNTLIMGLGT QGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PDPSLCK ALAKCHKEK-------------------------------------VSGQVGSRSPSMIN -----------------------------NDSETLEECMVCSDMKRDTLFGPCGHIATCS LCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCASLMKKCVQCR AVVERRVPFIMCCGGKG--------TEDTSDD---------------------------- ------------------------------------------------------------ -----------------------------------ISSGNIPVLQKDKDN----TNVN-- --ADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERR ILLY-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >D_melanogaster_FBpp0075275 MSCAATLSSAKDSTNANASGGGGGGGGGGAPTNSNTNTNTNTQSTAVGVVVSSAAGTGVG VGGGGGGGGSLPGGTTSSSSASAAGGVAAGGGGNSAAALVR--RFSMEGVGARVIRG--- --PDWKWNKQDGGEGHVGTVRNFESAEEVVVVWDNGTAANYRCAGAYDLRILDSAPTGVK HEGTMCDTCRQQPIFGIRWKCAECINYDLCSICYHGDKHHLRHRFYRITTPGGERTMLEP RRKSKKVLARGIFPGARVVRGVDWQWEDQDGGVGRRGKVNEIQDWSSASPRSAAYVIWDN GSKNLYRVGFEGMADLKVVNDAKGSNVYRDHLPLLGENGPGKGPHGFQIGDKVTVDLDLE IVQSLQHGHGGWTDGMFECLSNAGMVVGIDEDHDIVVAYNSGNRWTFNPAVLTKV----- ----SSPTTAPPEFQVGDIVKICSDVESIKILQRGHGEWADAMQLTLGKIGRVQQVYHDN DLKVEVGNT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SWTYNPLAVCKVASSTASDGSCAPVIPSS--ERLSAILK KLFEPNVSGDATEEFVKAAANGFAARCEEYLAGAA-----QPSTSSASPSSGPDVNVNGV FAGHTALQAASQNGH------IEVIQVL-----------LRHAVDVEIEDKDGDRAVHHA AFGDEAAVIEILAKA-------GADLNARNKRRQTSLHIAVNKGHLNVVKTLLTLGCHPS LQDSEGDTPLHDAIS-KE--HDEMLSLLLDFGA--------------------------- --------------------DITLNNNN------------------------------GF NALHHAALKGN---------------------------PSAMKILLTK-TNRPWIVEEKK DDGYTALHLAALNNHVEIAELLVHMGKA--NMDRQNVNLQTALHLAVERQ----HVQIVK LLVQDGAD---------------------------------------------------- -----LNIPDK-DGDTPL----HEALRHHTLSQLKQLQDVEGFGK--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------LLMGL-R NANNKKASASIACFLAANGADLTLKNRKQQTPLDLC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PDPNLCK TLVKCYNERKTDDSELPGNVAGTSSSARARAASGSLNQSSSVNMPLSSLAASSTFPAASS SSIFALNGIANEMSQSLHED-------PPKSSASLDECLVCSDAKRDTVFKPCGHVSCCE TCAPRVKKCLICRETVSSREKIDECLVCSDRRAAVFFRPCGHMVACEHCSALMKKCVLCR TQIDEILSFSLCCGGSG--------RPEKVSVAAGAMATVGLPL---------------- -------------------------------------------PDDRFMEAAAAAACANA SGHSVAMNNTV---VTPVAGSSNQLNSQNNLLAAAAASSNVSNLSAAGNAMVAPSNVNNF QMDDVQKLKQQLQDIKEQTMCPVCFDRIKNMVFLCGHGTCQMCGDQIEGCPICRKTVEKR ILLF-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_gallus_ENSGALP00000024106 MSSS-------------------------------------------------------- ----------------------------------------RNNRVMVEGVGARVVRG--- --PDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDLRILDSAPTGIK HDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLES RRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDN GAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLE IVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANVVRS GDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDS DLKVEVCGT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SWTYNPAAVSKVASA----GSAI-SNASG--ERLSQLLK KLFETQESGDLNEELVKAAANGDVAKVEDLLKRP-------------------DVDVNGQ CAGHTAMQAASQNGH------VDILKLL-----------LKQNVDVEAEDKDGDRAVHHA AFGDEGAVIEVLHRG-------SADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS LQDSEGDTPLHDAIS-KK--RDDILAVLLEAGA--------------------------- --------------------DVTITNNN------------------------------GF NALHHAALRGN---------------------------PSAMRVLLSK-LPRPWIVDEKK DDGYTALHLAALNNHVEVAELLVHQGNA--NLDIQNVNQQTALHLAVERQ----HTQIVR LLVRAGAK---------------------------------------------------- -----LDIQDK-DGDTPL----HEALRHHTLSQLRQLQDMQDVGK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------VDTAWEPSKNTLIMGLGT QGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PDPSLCK ALAKCHKEK-------------------------------------VSGQVGSRSPSMIN -----------------------------NDSETLEECMVCSDMKRDTLFGPCGHIATCS LCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCASLMKKCVQCR AVVERRVPFIMCCGGKG--------TEDTTDD---------------------------- ------------------------------------------------------------ -----------------------------------ISSGNIPVMQKDKDN----TNVN-- --ADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERR ILLY-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_domestica_ENSMODP00000026850 MSNS-------------------------------------------------------- ----------------------------------------RNNRVMVEGVGARVVRG--- --PDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDLRILDSAPTGIK HDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLES RRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDN GAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLE IVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANVVRS GDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDS DLKVEVCGT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SWTYNPAAVSKVASA----GSAI-SNASG--ERLSQLLK KLFETQESGDLNEELVKAAANGDVAKVEDLLKRP-------------------DVDVNGQ CAGHTAMQAASQNGH------VDILKLL-----------LKQNVDVEAEDKDGDRAVHHA AFGDEGAVIEVLHRG-------SADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS LQDSEGDTPLHDAIS-KK--RDDILAVLLEAGA--------------------------- --------------------DVTITNNN------------------------------GF NALHHAALRGN---------------------------PSAMRVLLSK-LPRPWIVDEKK DDGYTALHLAALNNHVEVAELLVHQGNA--NLDIQNVNQQTALHLAVERQ----HTQIVR LLVRAGAK---------------------------------------------------- -----LDIQDK-DGDTPL----HEALRHHTLSQLRQLQDMQDVGK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------VDTAWEPSKNTLIMGLGT QGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PDPSLCK ALAKCHKEK-------------------------------------VSGQVGSRSPSMIS -----------------------------NDSETLEECMVCSDMKRDTLFGPCGHIATCS LCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQCR AVVERRVPFIMCCGGKG--------SEDATDD---------------------------- ------------------------------------------------------------ -----------------------------------IASGNIPVLQKDKDN----TNVN-- --ADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERR ILLY-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_carolinensis_ENSACAP00000007708 MSNS-------------------------------------------------------- ----------------------------------------RNNRVMVEGVGARVVRG--- --PDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDLRILDSAPTGIK HDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLES RRKSKKITARGIFTGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDN GAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLE IVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANVVRS GDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDS DLKVEVCGT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SWTYNPAAVSKVASA----GSAI-SNASG--ERLSQLLK KLFETQESGDLNEELVKAAANGDVAKVEDLLKRP-------------------DVDVNGQ CAGHTAMQAASQNGH------VDILKLL-----------LKQNVDVEAEDKDGDRAVHHA AFGDEGAVIEVLHRG-------SADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS LQDSEGDTPLHDAIS-KK--RDDILAVLLEAGA--------------------------- --------------------DVTITNNN------------------------------GF NALHHAALRGN---------------------------PSAMRVLLSK-LPRPWIVDEKK DDGYTALHLAALNNHVEVAELLVHQGNA--NLDIQNVNQQTALHLAVERQ----HTQIVR LLVRAGAK---------------------------------------------------- -----LDIQDK-DGDTPL----HEALRHHTLSQLRQLQDMQDVGK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------VDTAWEPSKNTLIMGLGT QGAEKKSAASIACFLAANGADLGIRNKKGQSPLDLC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PDPSLCK ALAKCHKEK-------------------------------------ASGQVGSRSPSMIS -----------------------------NDSETLEECMVCSDMKRDTLFGPCGHIATCS LCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCASLMKKCVQCR AVVERRVPFIMCCGGKG--------QEDATDD---------------------------- ------------------------------------------------------------ -----------------------------------ISSGNIPVLQKDKDN----TNVN-- --ADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERR ILLY-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >H_sapiens_ENSP00000261537 MSNS-------------------------------------------------------- ----------------------------------------RNNRVMVEGVGARVVRG--- --PDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDLRILDSAPTGIK HDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLES RRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDN GAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLE IVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRS GDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDS DLKVEVCGT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SWTYNPAAVSKVASA----GSAI-SNASG--ERLSQLLK KLFETQESGDLNEELVKAAANGDVAKVEDLLKRP-------------------DVDVNGQ CAGHTAMQAASQNGH------VDILKLL-----------LKQNVDVEAEDKDGDRAVHHA AFGDEGAVIEVLHRG-------SADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS LQDSEGDTPLHDAIS-KK--RDDILAVLLEAGA--------------------------- --------------------DVTITNNN------------------------------GF NALHHAALRGN---------------------------PSAMRVLLSK-LPRPWIVDEKK DDGYTALHLAALNNHVEVAELLVHQGNA--NLDIQNVNQQTALHLAVERQ----HTQIVR LLVRAGAK---------------------------------------------------- -----LDIQDK-DGDTPL----HEALRHHTLSQLRQLQDMQDVGK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------VDAAWEPSKNTLIMGLGT QGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PDPNLCK ALAKCHKEK-------------------------------------VSGQVGSRSPSMIS -----------------------------NDSETLEECMVCSDMKRDTLFGPCGHIATCS LCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQCR AVVERRVPFIMCCGGKS--------SEDATDD---------------------------- ------------------------------------------------------------ -----------------------------------ISSGNIPVLQKDKDN----TNVN-- --ADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERR ILLY-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >B_taurus_ENSBTAP00000009822 MSNS-------------------------------------------------------- ----------------------------------------RNNRVMVEGVGARVVRG--- --PDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDLRILDSAPTGIK HDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLES RRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDN GAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLE IVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRS GDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDS DLKVEVCGT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SWTYNPAAVSKVASA----GSAI-SNASG--ERLSQLLK KLFETQESGDLNEELVKAAANGDVAKVEDLLKRP-------------------DVDVNGQ CAGHTAMQAASQNGH------VDILKLL-----------LKQNVDVEAEDKDGDRAVHHA AFGDEGAVIEVLHRG-------SADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS LQDSEGDTPLHDAIS-KK--RDDILAVLLEAGA--------------------------- --------------------DVTITNNN------------------------------GF NALHHAALRGN---------------------------PSAMRVLLSK-LPRPWIVDEKK DDGYTALHLAALNNHVEVAELLVHQGNA--NLDIQNVNQQTALHLAVERQ----HTQIVR LLVRAGAK---------------------------------------------------- -----LDIQDK-DGDTPL----HEALRHHTLSQLRQLQDMQDVGK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------VDAAWEPSKNTLIMGLGT QGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PDPSLCK ALAKCHKEK-------------------------------------VSGQVGSRSPSMIS -----------------------------NDSETLEECMVCSDMKRDTLFGPCGHIATCS LCSPRVKKCLLCKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCASLMKKCVQCR AVVERRVPFIMCCGGKS--------AEDATDD---------------------------- ------------------------------------------------------------ -----------------------------------ISSGNIPVLQKDKDN----TNVN-- --ADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERR ILLY-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_mulatta_ENSMMUP00000013391 MSNS-------------------------------------------------------- ----------------------------------------RNNRVMVEGVGARVVRG--- --PDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDLRILDSAPTGIK HDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLES RRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDN GAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLE IVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRS GEAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDS DLKVEVCGT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SWTYNPAAVSKVASA----GSAI-SNASG--ERLSQLLK KLFETQESGDLNEELVKAAANGDVAKVEDLLKRP-------------------DVDVNGQ CAGHTAMQAASQNGH------VDILKLL-----------LKQNVDVEAEDKDGDRAVHHA AFGDEGAVIEVLHRG-------SADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS LQDSEGDTPLHDAIS-KK--RDDILAVLLEAGA--------------------------- --------------------DVTITNNN------------------------------GF NALHHAALRGN---------------------------PSAMRVLLSK-LPRPWIVDEKK DDGYTALHLAALNNHVEVAELLVHQGNA--NLDIQNVNQQTALHLAVERQ----HTQIVR LLVRAGAK---------------------------------------------------- -----LDIQDK-DGDTPL----HEALRHHTLSQLRQLQDMQDVGK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------VDAAWEPSKNTLIMGLGT QGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PDPNLCK ALAKCHKEK-------------------------------------VSGQVGSRSPSMIS -----------------------------NDSETLEECMVCSDMKRDTLFGPCGHIATCS LCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQCR AVVERRVPFIMCCGGKS--------SEDATDD---------------------------- ------------------------------------------------------------ -----------------------------------ISSGNIPVLQKDKDN----TNVN-- --ADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERR ILLY-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_familiaris_ENSCAFP00000026944 MSNS-------------------------------------------------------- ----------------------------------------RNNRVKKEGVGARVXGARLF PDPGCNWGKQDGGEGHVGPVGSLENPQEVVVVWYKGTAANSRCSGAVFLSILSFAPVGIK HDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLES RRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDN GAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLE IVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRS GDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDS DLKVEVCGT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SWTYNPAAVSKVASA----GSAI-SNASG--ERLSQLLK KLFETQESGDLNEELVKAAANGDVAKVEDLLKRP-------------------DVDVNGQ CAGHTAMQAASQNGH------VDILKLL-----------LKQNVDVEAEDKDGDRAVHHA AFGDEGAVIEVLHRG-------SADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS LQDSEGDTPLHDAIS-KK--RDDILAVLLEAGA--------------------------- --------------------DVTITNNN------------------------------GF NALHHAALRGN---------------------------PSAMRVLLSK-LPRPWIVDEKK DDGYTALHLAALNNHVEVAELLVHQGNA--NLDIQNVNQQTALHLAVERQ----HTQIVR LLVRAGAK---------------------------------------------------- -----LDIQDK-DGDTPL----HEALRHHTLSQLRQLQDMQDVGK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------VDAAWEPSKNTLIMGLGT QGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PDPSLCK ALAKCHKEK-------------------------------------VSGQVGSRSPSMIS -----------------------------NDSETLEECMVCSDMKRDTLFGPCGHIATCS LCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCASLMKKCVQCR AVVERRVPFIMCCGGKS--------SEDATDD---------------------------- ------------------------------------------------------------ -----------------------------------ISSGNIPVLQKDKDN----TNVN-- --ADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERR ILLY-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_troglodytes_ENSPTRP00000016856 MSNS-------------------------------------------------------- ----------------------------------------PNNRVMVEGVGARVVRG--- --PDWKWGKQDGGEGHVGTVRSFESPEEVVVVCDNGTNTNYRCSGAYDF-ILDSAPTGIK HDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLES RRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDN GAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLE IVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRS GDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDS DLKVEVCGT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SWTYNPAAVSKVASA----GSAI-SNASG--ERLSQLLK KLFETQESGDLNEELVKAAANGDVAKVEDLLKRP-------------------DVDVNGQ CAGHTAMQAASQNGH------VDILKLL-----------LKQNVDVEAEDKDGDRAVHHA AFGDEGAVIEVLHRG-------SADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS LQDSEGDTPLHDAIS-KK--RDDILAVLLEAGA--------------------------- --------------------DVTITNNN------------------------------GF NALHHAALRGN---------------------------PSAMRVLLSK-LPRPWIVDEKK DDGYTALHLAALNNHVEVAELLVHQGNA--NLDIQNVNQQTALHLAVERQ----HTQIVR LLVRAGAK---------------------------------------------------- -----LDIQDK-DGDTPL----HEALRHHTLSQLRQLQDMQDVGK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------VDAAWEPSKNTLIMGLGT QGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PDPNLCK ALAKCHKEK-------------------------------------VSGQVGSRSPSMIS -----------------------------NDSETLEECMVCSDMKRDTLFGPCGHIATCS LCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQCR AVVERRVPFIMCCGGKS--------SEDATDD---------------------------- ------------------------------------------------------------ -----------------------------------ISSGNIPVLQKDKDN----TNVN-- --ADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERR ILLY-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_musculus_ENSMUSP00000054428 MSNS-------------------------------------------------------- ----------------------------------------RNNRVMVEGVGARVVRG--- --PDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDLRILDSAPTGIK HDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLES RRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDN GAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLE IVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRS GDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDS DLKVEVCGT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SWTYNPAAVSKVAPA----GSAI-SNASG--ERLSQLLK KLFETQESGDLNEELVKAAANGDVAKVEDLLKRP-------------------DVDVNGQ CAGHTAMQAASQNGH------VDILKLL-----------LKQNVDVEAEDKDGDRAVHHA AFGDEGAVIEVLHRG-------SADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS LQDSEGDTPLHDAIS-KK--RDDILAVLLEAGA--------------------------- --------------------DVTITNNN------------------------------GF NALHHAALRGN---------------------------PSAMRVLLSK-LPRPWIVDEKK DDGYTALHLAALNNHVEVAELLVHQGNA--NLDIQNVNQQTALHLAVERQ----HTQIVR LLVRAGAK---------------------------------------------------- -----LDIQDK-DGDTPL----HEALRHHTLSQLRQLQDMQDVGK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------VDAAWEPSKNTLIMGLGT QGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PDPSLCK ALAKCHKEK-------------------------------------VSGQVGSRSPSMIS -----------------------------NDSETLEECMVCSDMKRDTLFGPCGHIATCS LCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCASLMKKCVQCR AVVERRVPFITCCGGKS--------SEDPSDE---------------------------- ------------------------------------------------------------ -----------------------------------ISSGNIPVLQKDKDN----TNVN-- --ADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERR ILLY-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >R_norvegicus_ENSRNOP00000018025 MSNS-------------------------------------------------------- ----------------------------------------RNNRVMVEGVGARVVRG--- --PDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDLRILDSAPTGIK HDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLES RRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDN GAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLE IVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRS GDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDS DLKVEVCGT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SWTYNPAAVSKVAPA----GSTI-SNASG--ERLSQLLK KLFETQESGDLNEELVKAAANGDVAKVEDLLKRP-------------------DVDVNGQ CAGHTAMQAASQNGH------VDILKLL-----------LKQNVDVEAEDKDGDRAVHHA AFGDEGAVIEVLHRG-------SADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS LQDSEGDTPLHDAIS-KK--RDDILAVLLEAGA--------------------------- --------------------DVTITNNN------------------------------GF NALHHAALRGN---------------------------PSAMRVLLSK-LPRPWIVDEKK DDGYTALHLAALNNHVEVAELLVHQGNA--NLDIQNVNQQTALHLAVERQ----HTQIVR LLVRAGAK---------------------------------------------------- -----LDIQDK-DGDTPL----HEALRHHTLSQLRQLQDMQDVGK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------VDAAWEPSKNTLIMGLGT QGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PDPSLCK ALAKCHKEK-------------------------------------VSGQVGSRSPSMIS -----------------------------NDSETLEECMVCSDMKRDTLFGPCGHIATCS LCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCASLMKKCVQCR AVVERRVPFITCCGGKS--------SEEPSDD---------------------------- ------------------------------------------------------------ -----------------------------------ISSGNIPVLQKDKDN----TNVN-- --ADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERR ILLY-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >E_caballus_ENSECAP00000021243 ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GIK HDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLES RRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDN GAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLE IVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRS GDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDS DLKVEVCGT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SWTYNPAAVSKVASA----GSAI-SNASG--ERLSQLLK KLFETQESGDLNEELVKAAANGDVAKVEDLLKRP-------------------DVDVNGQ CAGHTAMQAASQNGH------VDILKLL-----------LKQNVDVEAEDKDGDRAVHHA AFGDEGAVIEVLHRG-------SADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS LQDSEGDTPLHDAIS-KK--RDDILAVLLEAGA--------------------------- --------------------DVTITNNN------------------------------GF NALHHAALRGN---------------------------PSAMRVLLSK-LPRPWIVDEKK DDGYTALHLAALNNHVEVAELLVHQGNA--NLDIQNVNQQTALHLAVERQ----HTQIVR LLVRAGAK---------------------------------------------------- -----LDIQDK-DGDTPL----HEALRHHTLSQLRQLQDMQDVGK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------VDAAWEPSKNTLIMGLGT QGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PDPSLCK ALAKCHKEK-------------------------------------VSGQVGSRSPSMIS -----------------------------NDSETLEECMVCSDMKRDTLFGPCGHIATCS LCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQCR AVVERRVPFIMCCGGKS--------SEDATDD---------------------------- ------------------------------------------------------------ -----------------------------------ISSGNIPVLQKDKDN----TNVN-- --ADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERR ILLY-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_latipes_ENSORLP00000014095 ------------------------------------------------------------ --ADAATSFLRAARSGNLDKALDHIKNG--ININIANQNGLNGLHLASKEGHVKMVLELL HSGIELEATTKKGNTALHIAALAGQEKVVAELVNYGANVNAQS-------HKGFSPLYMA AQENHLEVVKFLLENGANQSLPTEDGFTPLAVALQQGHENVVALLINYGTKGKVRLPALH IAARNDDTRTAAVLLQNDPNPDVLSK--------TG-FTPLHIAAHYENMSVAQLLLNRG ANVNFTPKNGITPLHIASRRGNVMMVR---LLLDRGAQIDAQTKDELTPLHCAARNGHVR IIEILLEHGAPIQAKTKNGLSPIHMAAQGDHMDCVRQL--LQYNAEIDDITLDHLTPLHV AAHCGHHRMAKVLLDKGAKANARALNGFTPLHIACKKNHMRSMDLLLKHSASLEAVTEVM MEKRKIFFFFA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------RPPTLX XXXIVKNFLQRGASPNASNV--KVETPLHMASRAGHCEVAQFLLQNAAQVDARAKDDQTP LHCAARMGHKELVKLLLDHKANPDSATTAGHTPLHIAAREGHIHTIRILLDAGAQQVKMT KKGFTPLHVASKYGK------VDVAELL-----------LERGANPNAAGKNGLTPLHVA VHHNNLDVVKLLVSK-------GGSAHSTARNGYTPLHIAAKQNQIEVASVLLQNGASPN CESLQGITPLHLASQ-EG--RPDMVAMLISKQA--------------------------- --------------------NVNLGNKN------------------------------GL TPLHLVAQEGH---------------------------VGIADTLVKQ-GAS--VYAAS- RMGYTPLHVACHYGNIKMVKFLL-QQQA--HVNAKTRMGYTPLHQAAQQG----HTDIVT LLLKHGAL---------------------------------------------------- -----PNEITS-KGACPP----GHAKRLGYISVIDVLKLVTEESVSTIT----TEKHRMS FPETVDEIL--DVSEDE-------------ENFHISPT-GDELLGLDGARYFKLDDFK-D QDDDFLSPKKTLRDFE----------GGVGTT---------PYSPAIPRIPCVSPETVQL -----D-QHTPIPLPKEYDEDSLIPSSPATETSDNVSPVASPIHTG------------FL VSFMVDARGGSMRGSRHHGLRVIIPPRTCAAPTRITCRLVKPQKLTTPPPLVEGEGLASR IISLGPSSMQ---------------------------------FLGPVIVEIPHFASLGR GDRELVVLRSENGSVWKEHRNRYGDEVLETILNGMDEDLESQEELEKKRIRRIISTDFPL YFAVVSRIQQESDLIGPEGGRLTSKLVPHVEAIFPESAVTKRVRLGL-QAQPIPDELLTR QLGNQATFSPVVTIEPRRRKFHRPIGLRIPLPPSW-RESPRDA----GEGDTTSLRLLCS VIGGTAPAQWEDITGTTKLMYAHNCASFTTNVSARFWLADCPRTAEAVTFANLLYKEL-- MAIPYMAKFVIFAKMNEAREG---RLRCYCMTDDKMDKTLELHENFSEVARSRDIELMEG MPLHLECSGNLVPIRKATQQPRSFSFQAFRDNRLPVSVKVRDSNKEATGFLSFLRKCTKY EDAQH--VLCNLNI-----------------TMPPCVKVAGSEERRRTLTPLALRERYSA LNDPAAVTVNA----MERTEIKINIISEQLGLSW-AELARELQFGVDDINRIRVEN-PNS LLDQSSTLLNLWASREGKKAKMESLY--TALRNIDRADIVASLEGQPPPAGPESLEEGAC RLSDRDSTLLSPSVINGYGLVQ-EELLSPASLQYSLQSPLGVEPYWQEVSSLECAPIATT EEDTLMEMSDVQVWPAGVSPSLVTVEDSSLEGSSRADDSE-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >X_tropicalis_ENSXETP00000026779 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ENKKTSLHEAVRRGD------MDQVNTL-----------LNFGIAVNCQDYRGWSLLHSA AFCGDLALVKYLLQK-------GASVNLRDVRSYTPLHRAAWTGHAELTDYLLQCGALPD IVNYCGETPLHLAAA-NG--HLLCVKILIQNKASIDIKDNNKWTPLQWCSI--------- -----NDQIDVLEYLVSLGASLEEKSTT------------------------------GM TLLHLSALAGN---------------------------LQVINYLLNT-NVD--INVKD- INGLTALHLAAENGHSKIIKCLL-KKGA--IVNITDINHLTPLHRAAGRG----YTEIVT LLLKQKAA---------------------------------------------------- -----VNNMDI-QNLTPL----HHAAYK-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------GQNDTSSILLQFGADIDSKDWLGKTPLHLA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------VERGHFDVVKTLKEWGADP---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_nigroviridis_ENSTNIP00000008004 ---------------------------------------MLSNEERRSAARRLAAKTSGK MQADASTSFLRAARSGNLEKALDHIRNG--IDINTANQNGLNGLHLASKEGHVKMVLELL HAGIELEATTKKGNTALHIAALAGQEKVVAELINYGANVNAQS-------HKGFSPLYMA AQENHLEVVKFLLENGANQSLPTEDGFTPLAVALQQGHENVVALLINYGTKGKVRLPALH IAARNDDTRTAAVLLQNDPNADVLSK--------TG-FTPLHIAAHYENMSVAQLLLNRG ANVNFTPKNGITPLHIASRRGNVMMVR---LLLDRGAQIDAKTKDELTPLHCAARNGHVR IIEILLEHGAPIQAKTKNGLSPIHMAAQGDHMDGVRQL--LQFNADIDDITLDHLTPLHV AAHCGHHRMVKVLLDKGAKANARALNGFTPLHIACKKNHMRSLDLLLKHSASLEAVTESG LTPLHVAAF--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MG HLNIVKTLLQRGASPNASNV--KVETPLHMASRAGHCEVAQFLLQNTAQVDAKAKDDQTP LHCAARMGHKELVKLLLDHRANPDSATTAGHTPLHICAREGHMHIIRILLDAGAQQTRMT KKGFTSLHVASKYGQ------VGVAELL-----------LDRGANANAAGKNGLTPLHVA VHHNNLDVVKLLVSK-------GGSAHSTARNGYTPLHIAAKQNQMEVASCLLQSGATPN AESLQGITPLHLAAQ-EG--RPDIAALLLSKQA--------------------------- --------------------NVNVGNKN------------------------------GL TPLHLVAQEGH---------------------------VGIADMLVKQ-GAS--IYAAT- RMGYTPLHVACHYGNIKMVKFLL-QQQA--HVNSKTRMGYTPLHQAAQQG----HTDIVT LLLKHGAQ---------------------------------------------------- -----PNEITSKNGTSPL----GIAKRLGYISVIDVLKLVTEESVSAVT----TEKHWMS FPETVDEIL--DVSEDEGRPSLFLSRLSVTNRLPLLST-GDELLGMDGGRYLKLDDFK-D QDEDFLSPKKTLRDFE----------GGVGTTFN-RFLSHRPYSPAIPRIPCVSPETVLL -----D-QHTPVPLPKEYDEDSLIPSSPATETSDNVSPVASPIHTG------------FL VSFMVDARGGSMRGSRHHGLRIIIPPRTCTAPTRITCRLVKPQKLTTPPPLVEGEGLASR IISLGPSSMQ---------------------------------FLGPVIVEIPHFASLGR GDRELVVLRSENGSVWKEHRNRYGDEVLETILNGMDEDLESLEELEKKRIRRILSTDFPL YFAVVSRIQQESDLIGPEGGRLSSRLVPHVEAIFPEAAVTKRVRLGL-QAQPIPDELLTR QLGNQATFSPVVTIEPRRRKFHRPIGLRIPLPPSW-RESPRDA----GEGDTTSLRLLCS VIGGTAPAQWEDITGTTKLMYASNCANFTTNVSARFWLADCPRTAEAVAFANLLHREL-- MAVPYMAKFVVFAKMNEAREG---RLRCYCMTDDKMDKTLELHENFAEVARSRDIELMEG MPLHLECSGNLVPVRKATQQPRSFSFQAFRDNRLPVAVKVRDANKEASGFLSFLRKCTKY EDTQH--VLCNLNI-----------------AMPPCIKVVGSEERKRTLTPLALRERYSV LNEPGLAVVNA----MERAELKISLISEQLGLSWAAELARELHFGVDDINRIRVEN-PNS LLDQSAALLGLWAGREGRRAKMESLC--TALKNIDRADIVAALEAPPPTAGS---SDGTS HWSSQASSLACPP--SGFGLVQ-DELLSPASMQYSLPSPLGAEPYWQEVSSLECAPMATT EEDTLMEMSELQVWPAGLSPSLVTVEDSSLEGSSRADDSEGAT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_rubripes_ENSTRUP00000005335 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------QDELTPLHCAARNGHVR IIEILLEHGAPIQAKTKNGLSPIHMAAQGDHMDCLRQL--LQYNAEIDDITLDHLTPLHV AAHCGHHRMVKVLLDKGAKANARALNGFTPLHIACKKNHMRSMDLLLKHSASLEAVTESG LTPLHVAAF--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MG HLNIVKTLLQRGASPNASNV--KVETPLHMASRAGHCEVAQFLLQNTAQVDAKAKDDQTP LHCAARMGHKELVKLLLDHKGNPDSATTAGHTPLHICAREGHMHIIRILLDAGAQQIRMT KKGFTPLHVASKYGK------VDVAELL-----------LERGANPNAAGK-GLTPLHVA VHHNNLDVVKLLVRK-------GGSAHSTARNGYTPLHIAAKQNQMEVASCLLQNGATPN AESLQGITPLHLAAQ-EG--RPDIAALLISKQA--------------------------- --------------------NVNVGNKN------------------------------GL TPLHLVAQEGH---------------------------VGIADMLVKQ-GAS--IYAAT- RMGYTPLHVACHYGNIKMVKFLL-QQQA--QVNSKTRMGFTALHQAAQQG----HTDIVT LLLKHGAQ---------------------------------------------------- -----PNEMTA-NGTSPL----GIAKRLGYISVIDVLKLVTEESMAAVT----TEKHWMS FPETVDEIL--DVSEDE----------------------GDELLGMDGGRYLKLDDFK-D QDDDFLSPKKTLRDFE----------GGVGTTSCLHFLSSLPVQQAIFSRDSQNSLCVSG -----DCHHTPVPLPKEYDEDSLIPSSPATETSDNVSPVASPIHTG------------FL VSFMVDARGGSMRGSRHHGLRIIIPPRTCTAPTRITCRLVKPQKLTTPPPLVEGEGLASR IISLGPSSMQ---------------------------------FLGPVIVEIPHFASLGR GDRELVVLRSENGSVWKEHRNRYGDEVLETILNGMDEDLESHEELEKKRIRRLISTDFPL YFAVVSRIQQESDLIGPEGGRLSSRLVPHVEAIFPEAAVTKRVRLGL-QAQPIPDELLTR QLGNQATFSPVVTIEPRRRKFHRPIGLRIPLPPSW-RESPRNA----GEGDTTSLRLLCS VIGGTAPAQWEDITGTTKLMYASNCANFTTNVSARFWLADCPRTAEAVTFANLLYREL-- MAVPYMAKFVIFAKMNEAREG---RLRCYCMTDDKMDKTLELHENFSEVARSRDIELMEG MPLHLECSGNLVPMRKATQQPRSFSFQAFRDNRLPVSVKVRDSNKDAAGFLSFLRKCTKY EDVQH--VLCNLNI-----------------IMPPCVKVVGSEERKRTLTPLALRERYSV LNEPCLPVVNA----MERTEVKINTISEQLGLSW-AELARELHFSVDDINRIRVEN-PNS LLDQSTALLNLWATRESRRAKMETLC--TALKNIDRADIVTALE---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_pygmaeus_ENSPPYP00000015189 -----------------------------------------------------MIVDKLL DDSRGGEGLRDAAGGCGLMTSPLNLSYFYGASPPAAAPGACDASCSVSGPSAPGSPGSDS SDFSSASSVSSCGA------------------------------------VESRSRGCAR -----AERQPVEPHMGVGRQ-----------------QRGPFQGVRVKNSVKELLLHIRS HKQKAS--------------------------------GQAVDDFKPQGVNIEQFRELKN TVSYSGKRKGSDSLSDGPACKRPALLH---SQFLTPPQTPTPGESMEDVHLNEPK----- -----QDSSADLLQNIINIKNECSPVSL-NTV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------QTSSSVQQQNDAHLHSFSMMPSS ACEAMAG-HEMASDSSNTSLPFSNM-G----------------------------NPMNT TQLGKSLFQWQVEQE------ESKLANI-----------S--QDQFLSKDADGDTFLHIA VAQGRRALSYVLARK---MNA-LHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN TTDCWGRTPLHVCAE-KG--HSQVLQAIQKGAVG-------------------------- ---------------SNQFVDLEATNYD------------------------------GL TPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQM-GAA--VEAKDR KSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVR LLMRKGAD---------------------------------------------------- -----PSTRNL-ENEQPV----HLVPDG-------------------------------- -----------PVGEQ-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------IRRI LKG--------------------------------------------------------- -------------------------------KSIQQRAPPY------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >B_taurus_ENSBTAP00000004242 ------------------------------------------------------LHLNGW GRADAATSFLRAARSGNLDKALDHLRNG--VDINTCNQNGLNGLHLASKEGHVKMVVELL HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS-------QKGFTPLYMA AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH IAARNDDTRTAAVLLQNDPNPDVLSK--------TG-FTPLHIAAHYENLNVAQLLLNRG ASVNFTPQNGITPLHIASRRGNVIMVR---LLLDRGAQIETRTKDELTPLHCAARNGHLR ISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL--LQYNAEIDDITLDHLTPLHV AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMELLLKMGASIDAVTESG LTPLHVASF--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MG HLPIVKSLLQREASPNVSNV--KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETALALLEKEASQTCMT KKGFTPLHVAAKYGK------VRMAELL-----------LEHDAHPNAAGKSGLTPLHVA VHHNHLDVVRLLLPR-------GGSPHSPALNGYTPLHIAAKQNQLEVARSLLQYGGSAN AESVQGVTPLHLAAQ-EG--HAEMVALLLSKQA--------------------------- --------------------NGNLGNKS------------------------------GL TPLHLVAQEGH---------------------------IPVADVLIKH-GVT--VDATT- RMGYTPLHVASHYGNIKLVKFLL-QHKA--DVNAKTKLGYSPLHQAAQQG----HTDIVT LLLKHGAS---------------------------------------------------- -----PNEVSS-NGTTPL----AIAKRLGYISVTDVLKVVTDETTVQLI----TDKHRMS FPETVDEIL--DVSEDE----------------------GEDL-GPRAER----PDAR-D VDEE-----KELLDFV----------PKLDQVV---------ESPAIPRIPCVTPETVVI RADEPD-QVS-----KEYDEDSLIPSSPATETSDNISPVASPVHTG------------FL VSFMVDARGGSMRGSRHNGLRVVVPPRTCAAPTRITCRLVKPQKLPTPPPLAEEEGLASR VIALGPTGVQ---------------------------------FLSPVIVEIPHFASQGR GDRELVVLRSENGSVWKEHKNRYGESYLDQILNGMDEELGSLEELEKKRVCRIVTTDFPL YFVIMSRLYQDYDTIGPEGGSLTSKLVPLVQATFPENAVTKRVKLAL-QAQPVPDELVTK LLGNQATFSPIVTVEPRR------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_aculeatus_ENSGACP00000023402 ----------------------TSQTFTRCRKLKKVEARRERNTSMDSNRIHLQYMNSSS LQADASTSFLRAARSGNLDKAHDHLKNG--ISINIANQNGLNGLHLASKEGHVKMVLELL HSGIELEATTKKGNTALHIAALAGQEKVVAELVNYGANVNAQS-------HKGFSPLYMA AQENHLEVVKFLLENGANQSLPTEDGFTPLAVALQQGHENVVALLINYGTKGKVRLPALH IAARNDDTRTAAVLLQNDPNADVLSK--------VDWFTPLHIAAHYENMSVAQLLLNRG SQCKLHPQNGITPIHIASRRGNVMMVR---LLLDRGAQIDAVTKDELTPLHCAARNGHAR IIEILLEHGAPIQAKTKNGLSPIHMSAQGDHMDCVRQL--LQYNAEIDDITLDHLTPLHV AAHCGHHRMAKVLLDKGAKANARALNGFTPLHIACKKNHMRSMDLLLKHSASLEAVTESG LTPLHVAAF--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MG HLNIVKNLIQRGASPNASNV--KVETPLHMASRAGHCEVAQFLLQNTAQADARAKDDQTP LHCAARMGHKELVKMLLEHKASPDSATTAGHTPLHISAREGHIHTIRILLDAGAQQTKMT KKGFTPLHVASKYGK------VDVAELL-----------LERGANPNAAGKNGLTPLHVA VHHNNLDVVRLLVSK-------GGSAHSTARNGYTSLHIAAKQNQIEVASCLLQNGATPN VESLQGITPLHLASQ-EG--RPDMVALLISKQA--------------------------- --------------------NVNLGNKS------------------------------GL TSLHLVAQEGH---------------------------VGIADTLVKQ-GAS--VYAAS- RMGYTPLHVACHYGNIKMVKFLL-QQQA--HVNSKTRMGYTPLHQAAQQG----HTDIVT MLLKHGAH---------------------------------------------------- -----PNEITS-NGTSPL----GIAKRLGYISVIDVLKLVTEESVSAIT----TEKHRMS FPETVDEIL--DVSEDE-------------VCRPCSVLRGDELLGMDGARYLKLDDFK-D QDDDFLSPKKSLRDFE----------GGLGTT---------PYSPAIPRIPCVSPETVLL -----D-QHTPVPLPKEYDDDSLIPSSPATETSDNVSPVASPIHTG------------FL VSFMVDARGGSMRGSRHHGLRVIIPPRTCTAPTRITCRLVKPQKLTTPPPLVEGEGLASR IISLGPSSMQ---------------------------------FLGPVIVEIPHFASLGR GDRELVVLRSENGAVWKEHRNRYGDEVLETILNGMDEDLESHDELEKKRIRRIISTDFPL YFAVVSRIQQESELIGPEGGRLTSQLVPRVEAIFPETAVTKRVRLGL-QAQPIPDEMLTR HLGNQATFSPVVTIEPRRRKFHRPIGLRIPLPPSW-RESPRDA----GEGDTTSLRLLCS VIGGTAPAQWEDITGTTKLMYAHSCANFTTNVSARFWLADCPRTAEAVTFANLLYREL-- MAVPYMAKFVIFAKMNEAREG---RLRCYCMTDDKMDKTLELHENFSEVARSRDIELMEG MPLHLECSGNLVPIRKATQQPRSFSFQAFRDNRLPVSVKVRDSNKEAAGFLSFLRKCTKY EETQH--VLCNLNI-----------------TMPPCVKVAGSEERRRTLTPLALRERYSA LNEPGVATVNA----MQRTELKINIISEQLGLSW-AELARELQFGVDDINRIRVEN-PNS LLEQSSALLNLWASREGKRAKMESLY--AALKNIDRADIVTSLEGQVPQAAPGFLEEGAC RLGDRDSTLLSPSVLNGYGLVQ-EELLSPASMQYSLPSPLGSEPYWQEVSSLECAPIATT EEDTLMEMSEVQVWPAGVSPSLVTVEDYSLEGSSRADDSEGATLSLPCSWGRPSSGAS-- ----------------GPQEPATALAEWDRVRASGAVPKVNLNGQLGGQRLE------GR RGEVIALGLGSVEGISVVAGQQVYAQRYEMSGVSRALEHN-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_domestica_ENSMODP00000028746 ------------------------------------------------------------ -------------------------------------QNGLNGLHLASKEGHVKMVVELL HKEIVLETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS-------QKGFTPLYMA AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH IAARNDDTRTAAVLLQNDPNADVLSK--------TG-FTPLHIAAHYENLNVAQLLLNRG ASVNFTPQNGITPLHIASRRGNVIMVR---LLLDRGAEIETRTKDELTPLHCAARNGHVR ISELLLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL--LQYNAEIDDITLDHLTPLHV AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMELLLKTGASIDAVTESG LTPLHVASF--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MG HLPIVKNLLQRGASPNVSNV--KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHITAREGHVETALALLEKEASQACMT KKGFTPLHVAAKYGK------VNVAELL-----------LERDAHPNAAGKNGLTPLHVA VHHNNLEIVKLLLPR-------GGSPHSPAWNGYTPLHIAAKQNQMELASNLLQYGGSAN AESVQGVTPLHLAAQ-EG--HAEMVALLLSKQA--------------------------- --------------------NGNLGNKS------------------------------GL TPLHLVAQEGH---------------------------VAVADVLVKQ-GVT--VDATT- RMGYTPLHVASHYGNIKLVKFLL-QHQA--DVNAKTKLGYTPLHQAAQQG----HTDIVT LLLKNGAS---------------------------------------------------- -----PNEVSS-NGTTPL----AIAKRLGYISVTDVLKIVTDETSVVLV----SDKHRMS FPETVDEIL--DVSEDE----------------------GEELMGSKPER----PDSR-D ADEE-----KELLDFV----------PKLDQVV---------ESPAIPRIPCVTPETVVI RAEEPE-QAS-----KEFDEDSLIPSSPATETSDNISPVASPVHTG------------FL VSFMVDARGGSMRGSRHNGLRVIIPPRACAAPTRITCRLVKPQKLTTPPPLAEEEGLASR IIALGPTGAQ---------------------------------FLSPVIVEIPHFASHGR GDRELVVLRSENGSMWKEHRSRYGESYLDQALNGMDEELESLEELEKKRVCRIVTTDFPL YFVVMSRLCQDFDMIEPEGGSLKSKLVPMVQATFPETAVTKKVKLALQQSQSIDDVLFSM FSMNPRKFLPSLAI---RQMIVIMPALLLPL-KDW-EDRLKFY----DENPLREVRIIRS FDLG-NEVSWPTVSNK-----FSACIDFPLKTKALSSSKAIPEMENSPPLALNFRSSLLD PSASYLGHFQVIKDLSTSSLNLGMSLQGKAIVRDERER--EERPQIQQFATPCSIKVLEG MPLFAELSGNLVPVKKAAQQ-RSFHFQSFRENRLAIPVKVRDSSREAGGSLSFLRKAMKY EDSQH--ILCHLNI-----------------TMPPCTKGSGADERRRTLTPLALRERYSL LSESTLGSLSG----TDRADMKMVIISEHLGLSW-AELARELQFGVEDINRIRVEN-PNS LLEQSSALLNLWVIREGKNAKMENLY--TALRNIDRSEIVNMLEGSGRQSRS---LKPDR RYPDRDYS-LSPSQMNGQEQGRVRERPSRGIKSFLFRSRPGGGRWGKRRGRPKGSRPSAE EGQEGREPRALRELRGPLGSPVCPGYEPELR----------------------------- ------------------------------------------------------------ -------------------PGVRLPARLPHQGPPESFADHGSAEGLECRE---------- ------------------------------------------------------------ ---------------------------------------GELGGNELQDIPGEHVTEEQF TDEQGNIVTKKIIRKVVRQIDTSGDRATQE-------------------LDEAEVRGSST LQSELIEGRKGAQIVKRASLKRGKQ >X_tropicalis_ENSXETP00000006826 MSGS-------------------------------------------------------- ----------------------------------------RNNRVMVEGVGARVARG--- --PDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDLRILDSAPTGIK HDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLES RRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDN GAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLLIGDLVNIDLELE IVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANVVRS GDAAQGAEGGTSPFQVGDLVQICYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDN DLKVEVCGT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SWTYNPAAVSRVASV----GSAI-SNATG--ERLSQLLK KLFETQESGDLNEELVKAAANGDVAKVEDLLKRQ-------------------DVDVNGQ CAGHTAMQAASQNGH------VDILKLL-----------LKHSVDVEAEDKDGDRAVHHA AFGDEGTVVEVLHRG-------GADLNARNKRRQTPLHIAVNKGHLQVVKKLLDFGCHPS LQDSEGDTPLHDAIS-KK--RDDILAVLLEAGA--------------------------- --------------------DVTITNNN------------------------------GF NALHHAALRGN---------------------------PSAMRVLLSK-LPRPWIVDEKK DDGYTALHLAALNNHVEVAELLVHQGNA--NLDIQNVNQQTALHLAVERQ----HTQIVR LLVRAEAK---------------------------------------------------- -----LDIQDK-DGDTPL----HEALRHHTLSQLRQLQDMQDVGK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------VDTTWEPSKNTLIMGLGT QGAEKKSAASIACFLAANGADLTIRNKKGQSPLDLC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PDPNLCK ALAKCHKEK-------------------------------------SSGQVGSHSPSMIS -----------------------------NDSETLEECMVCSDLKRDTLFGPCGHIATCS LCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCASLMKKCVQCR AVVERRVPFVMCCSGKG--------TEDVTDD---------------------------- ------------------------------------------------------------ -----------------------------------I-GGNIQALQKDKDN----TNVN-- --ADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFMCGHGTCQLCGDRMSECPICRKAIERR ILLY-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_nigroviridis_ENSTNIP00000017877 MTTG-------------------------------------------------------- ----------------------------------------RNNRAMMEGVGARVVRG--- --PDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDVRILDSAPTGIK HDGTMCDTCRQQPIIGIRW-CAECTNYDLCTTCYHGDKHHLRHRFYRITTPGSERVLLES RRKSKKITARGIFTGGRVVRGVDWQWEDQDGGNGRRGKVTEIQDWSAASPHSAAYVLWDN GAKNLYRVGFEGMSDLKCVQDAKGGTFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLE IVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANVVRS GEVAAGAEGGSSQFHVGDLVQICYDIDRIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDS DLKVEVCGT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SWTYNPAAVTKIAPS----GSAV-SNASGGLERLSQLLK KLFETQESGDITEELVKAAANGDLAKVEDILKRP-------------------DVDVNGQ CAGHTAMQAASQNGH------VDVLKLL-----------LKHNVDLESEDKDGDRAVHHA AFGDEGSVIEVLQRG-------GADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS LQDSEGDTPLHDAIS-KK--RDDMLSVLLESGA--------------------------- --------------------DVTITNNN------------------------------GF NALHHAALRGN---------------------------PSAMRVLLSK-LPRPWIVDEKK DDGYTALHLAALNNHVEVAELLVHQGSA--SLDIQNGNQQTALHLAVERQ----HTQIVR LLVRAEAK---------------------------------------------------- -----LDVQDK-DGDTPL----HEALRHHTLSQLRQLQDMQDVSK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LE-PWEPSKNTLIMGLGT QGAEKKSAASIACFLAANGADLTIRNKKGQSPLDLC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PDPSLCK ALAKCHKEK-------------------------------------SSGQVGTRSPSLNS -----------------------------N-IESLEECMVCSDMKRDTLFGPCGHIATCS LCSPRVKKCLICKDQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCASLMKKCVQCR AVVERRTPFVLCCGGKG--------MEDDAACRANAA----------------------- ------------------------------------------------------------ -------------------------------------SGNIPALQRDKDN----TNVN-- --ADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFMCGHGTCQLCGDRMSECPICRKAIERR ILLY-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_musculus_ENSMUSP00000110102 -----------------------------------------------------MIVDKLL DDSRGGEGLLDAAGDCGLMTSPLNLAYFYGASPP-SAPGAGDTGYLSAVPSAPGSPGSDS SDFSSTSSVSSCGA------------------------------------VESRPRGGAR -----AERPQVEPHMGVGRQ-----------------QRGPFQGVRVKNSVKELLLHIRS NKQKAS--------------------------------GQPVDEFKTQSVNIEQLTDLKS AVSAVGKRKGPDPLSDGPVCKRPALLP---SHFVTSPQTPTPGESMEDVRHSESK----- -----LDSSAALLQNIINIKNECNPVSL-NTVQVSWMSP-TVPQNS-PRDQCQDFHGGQA FSPPQKYQPFQVSGSPQMMDQASMYQYSPQTQNMQQPPPLPPQQQHQQNYPHNSPLQFSP YSRMSQSPKYDSNLFDT------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------HEPQFCTGQSFVSLLTGPGEPESLAVPVPAPTSIPPQTETQLQTFSLMPSN ACEAVVGVHDVGSHSLGTSLSLQNIMG----------------------------SPMNT TQLGKSFFQWQVEQE------ESKLANI-----------P--QDQFLARDGDGDTFLHIA VAQGRRALSYVLARK---MNA-LHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNLGAQVN TTDCWGRTPLHVCAE-KG--HSQVLQAIQKGAVR-------------------------- ---------------SNQFVDLEATNYD------------------------------GL TPLHCAVVAHNAVVHELQRNRQSHSPEVQDLLLRNKSLVDTIKCLIQM-GAA--VEAKDR KSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRVTQLDAVR LLMRKGAD---------------------------------------------------- -----PSTRNL-ENEQPV----HLVPDG-------------------------------- -----------PVGEQ-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------IRRI LKG--------------------------------------------------------- -------------------------------KSIQQRAPPY------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_intestinalis_ENSCINP00000014252 ---------------------------------MSDQ----------------------- ------SLVLHQSTRENMFPEENGEPYLEIIENP--KSRGFRFRYTCEGPSHGGIPGGSS DKNKKTFPAVKICN------------------------------------YQGYARIVVQ LVTN-EENPRLHPHSLVGKQ-C-QNGICTVQCGPKDMTA-TFPNLGIQHVTKKNVATILE ERYIAAEMQLSSINDGFPQEV-----------------QRNIKDEDRKRIAAKAQSEAKS IDLSVVRLMFIAYLPDSNGAFTIMLKP-----VISDAIFDSKAPNAAT--LKICR----- -----MDCNAGSASGGDEVYLLCDKVQK-DDI-QV-----VFSEE--DMQGNNLWEAYGS FSPTDVHRQFAIVFRTPAYKDTEIKMPVNVQVQLRRKSDNEVSESRPFTYLPNKS--DLE LIDRKRRKVMP-DFLDH--------TGN-GST-GGYSFNPQAAILPSSYNFSGNTGSGNT AGNGAGKVKEARRPPQKQQNPQKGPVDPSVLMKLKRIKTEPVQKSSPPTTYSNFPPIAYM SPAKSEPSPPAPMSIGGSPAAQVPQEEEYLPGTRIPLPKNARPHTGLPQMSFQNPIVLSQ QQQMQQQQIQQQQQQHLQQIQQQQAYSNYS-PMYSTTYGLDNTQHMVYSTPSPDYGQQII QQLSPQEVQEYEETVMNELSTVDAGDLVDIMNVDLNHNPMPQTTNSNIINQAYDQANILT QTNNTYGGGDGSFRGSVVDPIIPQPLSNAPLPILSQQFSQQLLELTEYDLADIESDAGAE RKPKPGNNNDDEQEEDYASAYCEEQDTTDSTAHEAEPKSFSTVQSDCCNVEADAAMLKME KLSLAPSMPTKLDSLKPEKKF---DSKQVETKTKGPLKRPVTSTTASVTQALEKYAVKTM NRNSSALHDFSVTGD------IRMLLVL-----------Q--RHLTDVRDCNGDSVLHVA VIHDQMQVLSSLLDVIVTLNNKQNIIDAVNPQKQTALQMAVLSDN--VDADLLKVGADPL VLDSYGNHSIHVACR-HG--NADILNRLLNC-K--------------------------- ---------------QVYDMEMDTKNFD------------------------------GL GCFHLAGKASSGT-------------------------RQCLGLLREF-AFD--VNMPDM KSRRTALHMAVEADNIVVAGCLISECDA--DLEASTYEGYTPLHVAASLD----HCEIAT LLLACGAD---------------------------------------------------- -----PEASSA-PP---------------------------------------------- ------------GRED-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GMTPLDLA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TS-DQ--------MRDL LNG-------VFMK-NIKEELDNSNYSDEEDL---ATLDPLIRLKLCKLLNLEKSGSDWY ALASRLSLDYIVPFIDTTENPTDLLL--DN-YMVIAG----LRSALMNIGRHDAVQLLNR AATTTCVDKFDSNAT---------------------------EQCDSAFGSLPNQIDVI- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_aculeatus_ENSGACP00000022862 MTTG-------------------------------------------------------- ----------------------------------------RNNRAMMEGVGARVVRG--- --PDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDVRILDSAPTGIK HDRTMCDTCRQQPIIGIRWKCAECTNYDLCTTCYHGDKHHLRHRFYRITTPGSERVLLES RRKSKKITARGIFTGGRVVRGVDWQWEDQDGGNGRRGKVTEIQDWSAASPHSAAYVLWDN GAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLE IVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANVVRS GDAAAGAEGGTSQFVVGDLVQICYDIDRIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDS DLKVEVCGT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SWTYNPAAVTKIAPS----GSAV-SNASG--ERLSQLLK KLFETQESGDINEELVKAAANGDLAKVEDILKRA-------------------DVDVNGQ CAGHTAMQAASQNGH------VDVLKLL-----------LKHNVDLEAEDKDGDRAVHHA AFGDEGSVIEVLQRG-------GADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS LQDSEGDTPLHDAIS-KK--RDDMLSVLLEAGA--------------------------- --------------------DVTITNNN------------------------------GF NALHHAALRGN---------------------------PSLERLILXQ-LPRPWIVDEKK DDGYTALHLAALNNHVEVAELLVHQGNA--NLDIQNVNQQTALHLAVERQ----HTQIVR LLVRAEAK---------------------------------------------------- -----LDVQDK-DGDTPL----HEALRHHTLSQLRQLQDMQDVSK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------VE-PWEPSKNTLIMGLGT QGAEKKSAASIACFLAANGADLTIRNKKGQSPLDLC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PDPSLCK ALAKCHKEK-------------------------------------SSGQVGTRSPSQNS -----------------------------N-IESLDECMVCSDLKRDTLFGPCGHIATCS LCSPRVKKCLICKDQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCASLMKKCVQCR AVVERRTPFVLCCGGKG--------MEDETSLRG-CTGS--------------------- ------------------------------------------------------------ --------------SNTMAGGSQDLLQPNNL-ALSWSSGNIPGLQRDKDN----TNVN-- --ADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFMCGHGTCQLCGDRMSECPICRKAIERR ILLY-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >R_norvegicus_ENSRNOP00000039357 --------------------MA-----------------------------ERPRRSGSD PAADAATSFLRAARSGNLDKALDHLRNG--VDINTCNQNGLNGLHLASKEGHVKMVVELL HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS-------QKGFTPLYMA AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH IAARNDDTRTAAVLLQNDPNPDVLSK--------TG-FTPLHIAAHYENLNVAQLLLNRG ASVNFTPQNGITPLHIASRRGNVIMVR---LLLDRGAQIETRTKDELTPLHCAARNGHVR ISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL--LQYNAEIDDITLDHLTPLHV AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMELLLKTGASIDAVTESG LTPLHVASF--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MG HLPIVKNLLQRGASPNVSNV--KVETPLHMAARAGHTEVAKYLLQNKAKANAKAKDDQTP LHCAARIGHTSMVKLLLENDASPNLATTAGHTPLHTAAREGHVDTALALLEKEASQACMT KKGFTPLHVAAKYGK------VRLAELL-----------LEHDAHPNAAGKNGLTPLHVA VHHNNLDIVQLLLPR-------GGSPHSPAWNGYTPLHIAAKQNQIEVARSLLQYGGSAN AESVQGVTPLHLAAQ-EG--HTEMVALLLSKQA--------------------------- --------------------NGNLGNKS------------------------------GL TPLHLVAQEGH---------------------------VPVADVLIKH-GVT--VDATT- RMGYTPLHVASHYGNIKLVKFLL-QHQA--DVNAKTKLGYSPLHQAAQQG----HTDIVT LLLKNGAS---------------------------------------------------- -----PNEVSS-NGTTPL----AIAKRLGYISVTDVLKVVTDETSVVLV----SDKHRMS YPETVDEIL--DVSEDE-------------GTAHISLT-GDELVGSKAER----RDSR-D VGEE-----KELLDFV----------PKLDQVV---------ESPAIPRIPCVTPETVVI RSEDQE-QAS-----KEYDEDSLIPSSPATETSDNISPVASPVHTG------------FL VSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASR IIALGPTGAQ---------------------------------FLSPVIVEIPHFASHGR GDRELVVLRSENGSVWKEHKSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPL YFVIMSRLCQDYDTIGPEGGSLRSKLVPLVQATFPENAVTKKVKLAL-QAQPVPDELVTK LLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSW-TDNPRDS----GEGDTTSLRLLCS VIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVHFATLLYKEL-- TAVPYMAKFVIFAKMNDPREG---RLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEG MPLFAELSGNLVPVKKAAQQ-RSFHFQSFRENRLAIPVKVRDSSREPGGFLSFLRKPMKY EDAQH--ILCHLNV-----------------TMPPCTKGSGAEDRRRTLTPLTL--RYSI LSESRLGFTSD----TDRVEMKMAVIREHLGLSW-AGEPCKLLWSLSPLTAVITEN-EGT LHSLSWFYFLLCVLKQTTNGHLENLY--TALRNIDRSEIVNMLEGSGRQSRN---LKPDR RHGDREYS-LSPSQVNGYSSLQ-DELLSPASLHYALPSPLCADQYWNEVAVIDAIPLAAT EHDTMLEMSDMQVWSSGLTPSLVTAEDSSLE-CSKAEDSD-------------------A I-PEWKLEGAHSEDTQGPELGSQDLVEDDTVDSDATNGLADLL----------------- -------------------GQQRVHARITDSPSVRQVLDRSQARTVDWYK---QGSAASY PQEAAQSSWQ--EEVTQGPQSFQRRITTIQGPE-PGTLQEYEQVVV-------------- STREHVQRGPPESDSPKAGKDPS-------LWASESAFSQEVQGDELQNIPGEQVTEEQF TDEQGNIVTKKIIRKVVRQVDSSGAIDTQQ-------------------HEEVELRGSG- LQPDLIEGRKGAQIVKRASLKRGKQ >H_sapiens_ENSP00000325663 -----------------------------------------------------MIVDKLL DDSRGGEGLRDAAGGCGLMTSPLNLSYFYGASPPAAAPGACDASCSVLGPSAPGSPGSDS SDFSSASSVSSCGA------------------------------------VESRSRGGAR -----AERQPVEPHMGVGRQ-----------------QRGPFQGVRVKNSVKELLLHIRS HKQKAS--------------------------------GQAVDDFKTQGVNIEQFRELKN TVSYSGKRKGPDSLSDGPACKRPALLH---SQFLTPPQTPTPGESMEDVHLNEPK----- -----QESSADLLQNIINIKNECSPVSL-NTVQVSWLNPVVVPQSS-PAEQCQDFHGGQV FSPPQKCQPFQVRGSQQMIDQASLYQYSPQNQHVEQQP----------HYTHKPTLEYSP FPIPPQSPAYEPNLFDG------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------PESQFCPNQSLVSLLGDQRESENIANPMQTSSSVQQQNDAHLHSFSMMPSS ACEAMVG-HEMASDSSNTSLPFSNM-G----------------------------NPMNT TQLGKSLFQWQVEQE------ESKLANI-----------S--QDQFLSKDADGDTFLHIA VAQGRRALSYVLARK---MNA-LHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN TTDCWGRTPLHVCAE-KG--HSQVLQAIQKGAVG-------------------------- ---------------SNQFVDLEATNYD------------------------------GL TPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQM-GAA--VEAKDR KSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVR LLMRKGAD---------------------------------------------------- -----PSTRNL-ENEQPV----HLVPDG-------------------------------- -----------PVGEQ-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------IRRI LKG--------------------------------------------------------- -------------------------------KSIQQRAPPY------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_mulatta_ENSMMUP00000028405 -----------------------------------------------------MIVDKLL DDSRGGEGLRDAAGGCGLMTSPLNLGYFYGASPPAAAPGACDASCSASGPSAPGSPGSDS SDFSSASSVSSCGA------------------------------------VESRPRGGAR -----SERQPVEPHMGVGRQ-----------------QRGPFQGVRVKNSVKELLLHIRS HKQKGS--------------------------------GQAVDDFKTQGVNIEQFREWKN TVSYGGKRKGPDLFSDGPACKRPALLH---SQFLTPPQTPTPGESMEDVHHNEPK----- -----QDSSADLLQNIINIKNECSPVSL-NTVQVSWLNPVVVPQSS-PAEQCQDFHGGQV FSPPQKYQPFQVNSPPQVIDQASLYQYSPQNQHVEQQP----------HYTHKPTLEYSP FSRPPQSPTYEPNLFDG------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------QESPFCPNESLVSFLNNERESENIANPVPTSSSVRQQNDAHLHSFSMTPDS LCEAMAG-HEMASDASHTSLPFPNIPG----------------------------NPMNT TQLGKSFFQWQVEQE------ESKLANV-----------S--QDQFLSKDADGDTFLHIA VAQGRRALSYVLARK---MNA-LHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNLGAQVN TTDCWGRTPLHVCAE-KG--HCQVLQAIQKGAVG-------------------------- ---------------SNQFVDLEATNYD------------------------------GL TPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQM-GAA--VEAKDR KSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVR LLMRKGAD---------------------------------------------------- -----PSTRNL-ENEQPV----HLVPDG-------------------------------- -----------PVGEQ-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------IRRI LKG--------------------------------------------------------- -------------------------------KSIQQRAPPY------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_troglodytes_ENSPTRP00000056230 ------------------------------------------------------MVDKLL DDSRGERGLXDAXGGCXLMTSPLNLSYIYGESPPAAAPGACEASCSVLGPSAPGSPGSDS SDFSSASSVSSCGA------------------------------------VESRSRGGAR -----AERQPVEPHMGVGRQ-----------------QRGPFQGVRVKNSVKELLLHIRS HKQKAS--------------------------------GQAVDDFKTQGVNIEQFRELKN TVSYSGKRKGPDSLSDGPACKRPALLH---SQFLTPPQTPTPGESMEDVHLNEPK----- -----QESSADLLQNIINIKNECSPVSL-NTVQVSWLNPVVVPQSS-PAEQCQDFHGGQV FSPPQKCQPFQVRGSQQMIDQASLYQYSPQNQHVEQQP----------HYTHKPTLEYSP FPIPPQSPTYEPNLFDG------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------PESQFCPNQSLVSLLGDQRESENIANPMQTSSSVQQQNDAHLHSFSMMPSS ACEAMVG-HEMASDSSNTSLPFSNM-G----------------------------NPMNT TQLGKSLFQWQVEQE------ESKLANI-----------S--QDQFLSKDADGDTFLHIA VAQGRRALSYVLARK---MNA-LHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN TTDCWGRTPLHVCAE-KG--HSQVLQAIQKGAVG-------------------------- ---------------SNQFVDLEATNYD------------------------------GL TPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQM-GAA--VEAKDR KSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVR LLMRKGAD---------------------------------------------------- -----PSTRNL-ENEQPV----HLVPDG-------------------------------- -----------PVGEQ-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------IRRI LKG--------------------------------------------------------- -------------------------------KSIQQRAPPY------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_rubripes_ENSTRUP00000026577 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MGKEQELLEAARTGNLAAVEK---LLSGTGGSGNSGGHGASSHPLSSLLSIWRG PNVNCVDST--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --GYTPLHHAALNGH------SEVVEAL-----------LRNEALTNIADNKGCYPLHLA AWKGDEHIVKLLIHQ---GPS-HPKLNEQNNANETPLHCAAQYGHTGVVRILLEELTDPT MRNNKFETPLDLAAL-YG--RLEVVKLLLTAHP--------------------------- --------------------NLLSCNTK------------------------------KH TPLHLASRNGH---------------------------LPVVEVLLDA-GMD--INYETE KG--SALHEAALFGKTDVVQKLL-RAGI--DVNMVDQKGLSALDVVKEMP-SQKSREIAA LILDYTSGGGNTMSCLSATGHMTGKPPDIDLPPPPIPPPQESPRPSKKNSASVVGDLDRM SELILRLAPGP-EDESPY----EALCEATSCLSLDSLTSGKSSDRDSGRPESEAGKKDRA LHPTHAGPGHEEEVSS-------------------------------------------- ------------------------------------------------------------ ----KMTEEMQSPLHPHSLSVLSLLLLQTCYTNNSVDERLELVEEEEDHTYELLLTAQTK IPASIPECQSGKLNLQKGNDVILTQCKVSKVRQSVATGRCFSCGLIAPDSLSPNTVTLSP LGRRSTHTRCITHTHSFTMCHRANYQESGCKRGRVIQVSIPEPPLGSRIRRQKQHQTTAH IATTQNNSQSSQEQGAGVPEQFTGLLHGSSPVFDCSEDLFRLPGVQGSSQKRPEPQTPTK AKKEVTATPPAPRRPNMAAILTDCDPKAIYATVHKEPKDLGSGAASSVRTRPPGDLKLAR SLSKSDSDLLVSPPNEEEGVLGNRSESVSNCSTGKKRLEKSPSFTSEWDEIEKIMTLIGA GIDFSRDQQYATPGAAGRLLDQPVGDWLEHVGLPQYESKLLLNGFDDLHYMGSNVMEDQD LKEIGIADASHRKKILHAARSLPKVKALGCDGSSSLSSWLENLGLHEYLHNFLASGYRSL ECVKNLWELEIVNVLKISLLGHRKRIIASLA----------------------------- -------------------------------------------ERPYEEPPVKPPRLSQI RMESGTGRSMDPLLPIGESGRKKVPDADFEVPHKHQSERHRSSEWYDEKPREPRLTLRPP SLATPYALVQNWHHQPEKLIFESCAY--EA-SYLGSMLIKELRGTDSTQDACAKMRCTFF CQRSTEQMRKVPTIVLSITYKG-VKFIDAANKNIIAEHEIRNISCAAQDPEDLCTFAYIT KDLQTSHHYCHVFSTVDVNLTYEIILTLGQAFEVAYQLALQAQRTKQHQNLPSSDLIETK SSRPVPKPRGSVRK---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_rubripes_ENSTRUP00000032530 MTTG-------------------------------------------------------- ----------------------------------------RNNRAMMEGVGARVVRG--- --PDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDVRILDSAPTGIK HDGTMCDTCRQQPIIGIRWKCAECTNYDLCTTCYHGDKHHLRHRFYRITTPGSERVLLES RRKSKKITARGIFTGGRVVRGVDWQWEDQDGGNGRRGKVTEIQDWSAASPHSAAYVLWDN GAKNLYRVGFEGMSDLKCVQDAKGGTFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLE IVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANVVRS GEVAAGAEGGASQFHVGDLVQICYDIDRIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDS DLKVEVCGT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SWTYNPAAVTKIAPS----GSAV-SNASG--ERLSQLLK KLFETQESGDITEELVKAAANGDLAKVEDILKRP-------------------DVDVNGQ CAGHTAMQAASQNGH------VDVLKLL-----------LKHNVDLEAEDKDGDRAVHHA AFGDEGSVIEVLQRG-------GADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS LQDSEGDTPLHDAIS-KK--RDDMLSVLLESGA--------------------------- --------------------DVTITNNN------------------------------GF NALHHAALRGN---------------------------PSAMRVLLSK-LPRPWIVDEKK DDGYTALHLAALNNHVEVAELLVHQGNA--SLDIQNGNQQTALHLAVERQ----HTQIVR LLVRAEAK---------------------------------------------------- -----LDVQDK-DGDTPL----HEALRHHTLSQLRQLQDMQDVSK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LE-PWEPSKNTLIMGLGT QGAEKKSAASIACFLAANGADLTIRNKKGQSPLDLC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PDPSLCK ALAKCHKEK-------------------------------------SSGQVGTRSPSLNS -----------------------------N-IESLEECMVCSDMKRDTLFGPCGHIATCS LCSPRVKKCLICKDQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCASLMKKCVQCR AVVERRTPFVLCCGGKG--------MEDDAADDDDDAGS--------------------- ------------------------------------------------------------ --------------SNTMAGGSQDLLQPNNL-ALSWSSGNIPALQRDKDN----TNVN-- --ADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFMCGHGTCQLCGDRMSECPICRKAIERR ILLY-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_familiaris_ENSCAFP00000008529 ------------------PAKAQVQLRLWVCKQILNVKCQWEHFRVKNNKPRVLAYKDPK KKADAATSFLRAARSGNLDKALDHLRNG--VDINTCNQNGLNGLHLASKEGHVKMVVELL HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS-------QKGFTPLYMA AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH IAARNDDTRTAAVLLQNDPNPDVLSK--------TG-FTPLHIAAHYENLNVAQLLLNRG ASVNFTPQNGITPLHIASRRGNVIMVR---LLLDRGAQIETRTKDELTPLHCAARNGHVR ISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL--LQYNAEIDDITLDHLTPLHV AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMELLLKTGASIDAVTESG LTPLHVASF--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MG HLPIVKNLLQRGASPNVSNV--KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGQVETALALLEKEASQACMT KKGFTPLHVAAKYGK------VRVAELL-----------LGRDAHPNAAGKNGLTPLHVA VHHNHLDIVRLLLPR-------GGSPHSPAWNGYTPLHIAAKQNQMEVARSLLQYGGSAN AESVQGVTPLHLAAQ-EG--HAEMVALLLSKQA--------------------------- --------------------NGNLGNKS------------------------------GL TPLHLVAQEGH---------------------------VPVADVLIKH-GVT--VDATT- RMGYTPLHVASHYGNIKLVKFLL-QHQA--DVNAKTKQGYSPLHQAAQQG----HTDIVT LLLKNGAS---------------------------------------------------- -----PNEVSS-NGTTPL----AIAKRLGYISVTDVLKVVTDEPSFVLT----SDKHRLS FPETVDEIL--DVSEDE-------------GTAHITIM-GEELV-SKAEK----PDSR-D IDEE-----KELLDFV----------PKLDQVV---------ESPAIPRIPCVTPETVVI RSEEPE-QAS-----KEYDEDSLIPSSPATETSDNISPVASPVHTG------------FL VSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASR IIALGPTGAQ---------------------------------FLSPVIVEIPHFASHGR GDRELVVLRSENGSVWKEHKSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPL YFVIMSRLCQDFDTIGPEGGFLKSKLVPLVMATFPENAVTKRVKLAL-QAQPVPDELVTK LLGNQATFSPIVTVEPRRRKFYRPIGLRIPLPPSW-TDNPRDS----GEGDTTSLRLLCS VTGGTDQAQWEDITGTTKLVYANECAAFTTNVSARFWLSDCPRTAEAVNFATLLYKEL-- TAVPYMAKFVIFAKMNDSREG---RLRCYCMTDDKVDKTLEQHENFIEVARSRDIEVLEG MPLFAELFGNLVPVKKAAQQ-RSFHFQSFRENRLAIPVKVRDNSREPAGSLSFLRKAMKY EDTQH--ILCHLNI-----------------TMPAFVKTIMTDERRRTLTPLAL--RYSI LSESSLGFLSG----TDRADMKMAIISEHLGLSW-AELARELQFSVEDINRIRVEN-PNS LLEQSAALLNLWVLREGKNANMENLY--AALRNIDRSEIVNMLEGSGRQSRN---LKPER RHTDRDYS-SSPSQMNGYSSLQ-DELLSPASLHYALPSPLRADQYWNEVSVIDAIPLAAT EHDAMLEMSDMQVWSAGLTPSLVTAEDSSLE-CSKAEDSD-------------------A TGHEWKPEGVLSEEPQGPTLGSLDLVEDDTVDSDATNGLIDLLDQEEGQRSEEKLPGPKR QEDSTGAGQDSENEVSLVSGQQRVQAHITESPSVSRVMEPSQERLQDCNE---EGSIVSY LQDAAQGFWQ--EEVTQGPPSFQSTVTTIQELE-PSGSQEHKKVLV-------------- SASEHFWEEQPEAESTPADRERRRQSHLEWVQEAQSTFSQMAEGNEFQNIPGEQVTEEEF TDEQGNIVTKKIIRKVVRQIDSSGADDTQE-------------------HEE-------- -----------------DHTSTPKP >O_cuniculus_ENSOCUP00000004978 ---------------------------------MESC------------YDP-SLDGIIE YEEFKFDPSIVEPKEPA--PETDDGPYLVIVEQP--KQRGFRFRYGCEGPSHGGLPGASS EKGRKTYPTVKICN------------------------------------YEGPAKIEVD LVTH-SDPPRAHAHSLVGKQ-CSDLGICAVSVGPKDMTA-QFNNLGVLHVTKKNMMEIMI QKLQRQRLLSRPQG--LT------------------------EA-ERRELEQEAKELKKV MDLSIVRLRFSAFLRASDGSFSLPLKP-----VISQPIHDSXXXXXXX--XXXXX----- -----XXXXXXXXXXXXXXXXXXXXXXX-XXX-XX-----XXXXX--XXXX---XXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXX XXXXXXXXXXX-XXXXX--------XXX-XXX-XX-------------------XXXXXX XXXXXX------------------------------------------------------ -------------X-XXXXXXXXF-----PSSL--------------------------- ---------------------------AYS-PYQSGAAP--------------------- ------------------------------------------------------------ --MGCYPGG----------G------------------------------------GGAQ MAASA--PGVDAGEQA-----------TEAS---KP-----RQAQ-AP------------ ------------EMLQRAREY---NAR----------------------------LFGLA QRSSLAGLRH---HG------GRSLLAG-----------Q--RHLLTAQDENGDTPLHLA IIHGQTSVIEQISHVIYHAQH-LGVVNLTNHLHQTPLHLAVITGQTRVVSFLLQVGADPA LLDRHGDSAVHLALR-AGAGAPELLRALLCSGA--------------------------- ---------------PAVSQLLHMPDFE------------------------------GL YPVHLAVHARS---------------------------PKCLD-LVDS-GAE--XXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXLHA--NVNARTFAGNTPLHLAAGLG----SPTLTR LLLKAGAD---------------------------------------------------- -----IHAENE-EPLCPL----PSPPTS-------------------------------- ------------GSDS-------------------------------------------- ------------------------------------------DSE--------------- ------------------------------------------------------------ -----------------GPERDTRSSFRGHTPLDLT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------RS-TK--------VKTL LL---------NAA-QSAVEPPLTPPSPAGPG---LSLGDTALQNLEQLLDRLEAQGSWA ELAERLGLRSLVDTYRKTASLSGSLL--RS-YKLAGGDLAGLLEALSDMGLEEGVRLLRG PETRDKLPST---E----------------------------VKEDSAYGSQSVE--QEA EKLGLPPEPSGGLCHGHPQPQTELPPSPRPGPSVQPHLCQILFNTPCLPLGK-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_latipes_ENSORLP00000022107 MTTG-------------------------------------------------------- ----------------------------------------RNNRAMMEGVGARVVRG--- --PDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDVRILDSAPTGIK HDGTMCDTCRQQPIIGIRWKCAECSNYDLCTTCYHGDKHHLRHRFYRITTPGSERVLLES RRKSKKITARGIFPGGRVVRGVDWQWEDQDGGNGRRGKVTEIQDWSAASPHSAAYVLWDN GAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLE IVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANVVRS GEVAAGAEGGSSQFHVGDLVQICYDIDRIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDS DLKVEVCGT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SWTYNPAAVTKIAPS----GSAV-SNASG--ERLSQLLK KLFETQESGDINEELVKAAANGDLAKVEDILKRP-------------------DVDVNGQ CAGHTAMQAASQNGH------VDVLKLL-----------LKHNVDLEAEDKDGDRAVHHA AFGDEGSVIEVLQRG-------GADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS LQDSEGDTPLHDAIS-KK--RDDMLSVLLEAGA--------------------------- --------------------DVTITNNN------------------------------GF NALHHAALRGN---------------------------PSAMRVLLSK-LPRPWIVDEKK DDGYTALHLAALNNHVEVAELLVHQGNA--SLDIQNVNQQTALHLAVERQ----HTQIVR LLVRAEAK---------------------------------------------------- -----LDVQDK-DGDTPL----HEALRHHTLSQLRQLQDMQDVSK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------VE-PWEPSKNTLIMGLGT QGAEKKSAASIACFLAANGADLTIRNKKGQSPLDLC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PDPNLCK ALAKCHKEK-------------------------------------SSGQVGTRSPSLNS -----------------------------N-MESLEECMVCSDMKRDTLFGPCGHIATCS LCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCASLMKKCVQCR AVVERRTPFVLCCGGKG--------METAV---ETLLKN--------------------- ------------------------------------------------------------ --------------SNSMAGGSQDLLQPNNL-ALSWSSGNIPGLQRDKDN----TNVN-- --ADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFMCGHGTCQLCGDRMSECPICRKAIERR ILLY-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_musculus_ENSMUSP00000113571 --------------------MAQAAKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRK KKADAATSFLRAARSGNLDKALDHLRNG--VDINTCNQNGLNGLHLASKEGHVKMVVELL HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS-------QKGFTPLYMA AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH IAARNDDTRTAAVLLQNDPNPDVLSK--------TG-FTPLHIAAHYENLNVAQLLLNRG ASVNFTPQNGITPLHIASRRGNVIMVR---LLLDRGAQIETRTKDELTPLHCAARNGHVR ISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL--LQYNAEIDDITLDHLTPLHV AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMELLLKTGASIDAVTESG LTPLHVASF--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MG HLPIVKNLLQRGASPNVSNV--KVETPLHMAARAGHTEVAKYLLQNKAKANAKAKDDQTP LHCAARIGHTGMVKLLLENGASPNLATTAGHTPLHTAAREGHVDTALALLEKEASQACMT KKGFTPLHVAAKYGK------VRLAELL-----------LEHDAHPNAAGKNGLTPLHVA VHHNNLDIVKLLLPR-------GGSPHSPAWNGYTPLHIAAKQNQIEVARSLLQYGGSAN AESVQGVTPLHLAAQ-EG--HTEMVALLLSKQA--------------------------- --------------------NGNLGNKS------------------------------GL TPLHLVSQEGH---------------------------VPVADVLIKH-GVT--VDATT- RMGYTPLHVASHYGNIKLVKFLL-QHQA--DVNAKTKLGYSPLHQAAQQG----HTDIVT LLLKNGAS---------------------------------------------------- -----PNEVSS-NGTTPL----AIAKRLGYISVTDVLKVVTDETSVVLV----SDKHRMS YPETVDEIL--DVSEDE-------------GTAHISIM-GDELVGSKAER----RDSR-D VGEE-----KELLDFV----------PKLDQVV---------ESPAIPRIPCVTPETVVI RSEDQE-QAS-----KEYDEDSLIPSSPATETSDNISPVASPVHTG------------FL VSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLNTPPPLAEEEGLASR IIALGPTGAQ---------------------------------FLSPVIVEIPHFASHGR GDRELVVLRSENGSVWKEHKSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPL YFVIMSRLCQDYDTIGPEGGSLRSKLVPLVQATFPENAVTKKVKLAL-QAQPVPDELVTK LLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSW-TDNPRDS----GEGDTTSLRLLCS VIGGTDQAQWEDITGTTKLIYANECANFTTNVSARFWLSDCPRTAEAVHFATLLYKEL-- TAVPYMAKFVIFAKMNDAREG---RLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEG MPLFAELSGNLVPVKKAAQQ-RSFHFQSFRENRLAIPVKVRDSSREPGGFLSFLRKTMKY EDTQH--ILCHLNI-----------------TMPPCTKGSGAEDRRRTLTPLTL--RYSI LSESRLGFTSD----TDRVEMRMAVIREHLGLSW-AELARELQFSVEDINRIRVEN-PNS LLDQSTALLTLWVDREGENAKMENLY--TALRNIDRSEIVNMLEGSGRQSRN---LKPER RHGDREYS-LSPSQVNGYSSLQ-DELLSPASLQYALPSPLCADQYWNEVAVIDAIPLAAT EHDTMLEMSDMQVWSAGLTPSLVTAEDSSLE-CSKAEDSD-------------------A I-PEWKLEGAHSEDTQGPELGSQDLVEDDTVDSDATNGLADLLGQEEGQRSE------KK RQEVSGTEQDTETEVSLVSGQQRVHARITDSPSVRQVLDRSQARTLDWDK---QGSTAVH PQEATQSSWQ--EEVTQGPHSFQRRITTIQGPE-PGALQEYEQVLV-------------- STREHVQRGPPETGSPKAGKEPS-------LWAPESAFSQEVQGDELQNIPGEQVTEEQF TDEQGNIVTKKIIRKVVRQVDSSGAIDTQQ-------------------HEEVELRGSG- LQPDLIEGRKGAQIVKRASLKRGKQ >D_melanogaster_FBpp0088239 ---------------------------MTLGDVRVENKIQTRSETCAINGMALDNKNGII KQNDATISFLRAARSGDIKKVMDFLDCGEISDINSCNANGLNALHLAAKDGYVDICCELL RRGIKIDNATKKGNTALHIASLAGQHDVINQLILYNANVNVQS-------LNGFTPLYMA AQENHDNCCRTLLANGANPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDVRGKVRLPALH IAAKKNDVNAAKLLLQHDPNADIVSK--------SG-FTPLHIAAHYGNVDIATLLLNNK ADVNYVAKHNITPLHVACKWGKLSLCT---LLLCRGAKIDAATRDGLTPLHCASRSGHVE VIKHLLQQNAPILTKTKNGLSALHMAAQGEHDEAAHLL--LDNKAPVDEVTVDYLTALHV AAHCGHVKVAKLLLDYKANPNARALNGFTPLHIACKKNRIKMVELLIKHGANIGATTESG LTPLHVASF--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MG CINIVIYLLQHEASADLPTI--RGETPLHLAARANQADIIRILLRS-AKVDAIAREGQTP LHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQENIVQVLLENGAENNAVT KKGFTPLHLACKYGK------QNVVQIL-----------LQNGASIDFQGKNDVTPLHVA THYNNPSIVELLLKN-------GSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVN IISKSGFSPLHLAAQ-GG--NVDMVQLLLEYGV--------------------------- ---------------------ISAAAKN------------------------------GL TPLHVAAQEGH---------------------------VLVSQILLEH-GAN--ISERT- RNGYTPLHMAAHYGHLDLVKFFI-ENDA--DIEMSSNIGYTPLHQAAQQG----HIMIIN LLLRHKAN---------------------------------------------------- -----PNALTK-DGNTAL----HIASNLGYVTVMESLKIVTSTSVINSNIGAIEEKLKVM TPELMQETLLSDSDDES----------------------CDDLLDHNHYKYMATDDLKAN YGQDQ---------------------KNFDTTN---------TDHDLTDVSVLNKKEILP ------------------NEMSCIELTEIGHKPDNVVIARSQVHLG------------FL VSFLVDARGGSMRGYRHNGVRIIVPPKACAEPTRITCRYVKPQRVVNPPPLMEGEALVSR ILEMSPVDGM---------------------------------FLSPITLEVPHYGTLRK NEREIIILRSDNGESWREH-NLYKDI--------IGEDINQTEEFHSDRIVRIVTQNVPH FFAVVSRVRQEVHVIGPDGGTVFSTAVPQVKAIFPPHALTKKIRVGL-QAQSVDLVECSK LLGQGVAVSPVVTVEPRRRKFHKAITLSIPAPKAC-TNSMVNACYGNGNSSSPTLRLLCS ISGGQTRATWEDVTGSTPLSFVRDSVTFTTTVSARFWLIDCRNIIDAGRMATELYSHL-- AKVPFYVKFVIFAKRISQTEA---KFSVFCMTDDKEDKTLEQQEYFKEVAKSRDIEVLQN QIVYLEFAGNIVPILKKGEQ-LYTKFQPFCENRLSFSAHIKD-QEFPHGRICFMTYPMVG PDEVPLKPLCTLNISVDFKTITNHLERDNLHSLNDCINAHGKLNHNENIVFGVKEQQVKK IDITKACIMSSDIKLIHEADVILDDICSHLGSDW-PLLANVLGVSQADIDLVKTEFLLND SVKQSMAMLQLWLE-HGGILTGNVLA--EALYKIGRSDIV------------------EK SFKNAEFGTHQPEKV---------------------------------------LPTAGI EKDGDYEQ---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_aegypti_AAEL011927-PA MACA-------------------------------------------------------- -----------------SASASTTGNSMEVVAPTNVSVATRPTRFTMEGVGSRVIRG--- --PDWKWGKQDGGEGHVGTVRNFESQEEVVVVWDNGTAANYRCAGAYDLRILDSAPTGIK HEGTMCDTCRQTPIFGIRWKCAECNNYDLCSICYHGDKHHLRHRFHRISTPGGEKTLLEP RRKSKKIAVRGIFPGARVVRGVDWQWEDQDGGNGRRGKVNEIQDWSSASPRSAAYVVWDN GAKNLYRVGFEGMADLKVVNDSKGNNVYRDHLPLLGEFGPGRGPHSFQIGDQVTVDLEIE IVQSLQHGHGGWTDGMYECLNTTGTVVGIDEDHDIVVAYPSSHRWTFNPTVLTIV----S SPASMLSENQLQQFAVGDFVKICSDLERIKILQRGHGEWAEAMVPTLGKVGRVQQVYHDN DLKVEVCNT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SWTYNPLAVTKVASS--SDGSTA-VTTNG--ERLSAILK KLFEPHASGDTTEELVKAAANGDVAKVEEFLSGSSAQNVPSSSTSSQDSSQVVKVDVNGV FAGHTALQAASQNGH------LEVIQVL-----------LRYNADVEIEDKDGDRAVHHA AFGDEPGVMGLLAKA-------GADLNARNKRRQTALHIAVNKGHFNVVKTLLELSCHPS LQDSEGDTPLHDAIS-KE--HDNMLSLLLDFGA--------------------------- --------------------DITLTNNN------------------------------GF NALHHAALKGN---------------------------PSAMKILLTK-TNRLWIVEEKK EDGYTALHLAALNNHVEIAELLVKMGKA--NMDCQNVNLQTALHLAVERQ----HVQIVK LLVREGAN---------------------------------------------------- -----LNIPDK-DGDTPL----HEALRHHTLSQLRQLQDVEGFGK--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------ILMGL-R NNTDKKASASIACFLAANGADLTIKNRKLQTPLDLC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PDPNLCK TLIKCYNERKTDDMDMA--AAGGTALPGSNMLRNGAPVAGAPTAPSSSSLVSGSTPGISA SGVVDANLLNDLNKMSIQPTVGGQNSVAGSNGSPLDECLLCSDQKRDTVFKPCGHVVCCD NCGPRIKKCLICREAVSEREKIGECLVCSDRKASVFFKPCGHMVACDNCAQIMKKCVQCR VQLEQKVPLSVCSGGPGNVVTVQYQRDEKKEVNQTVLQGI-------------------- ----------------------------------------------------------NK SGHGVAMNNTMSPNVSVVSGTPTSLTTMNNI----------------GTGNVAPNNLN-- LADDVQKLQQQLQDIKEQTMCPVCFDRMKNMVFMCGHGTCQMCGDQIEGCPICRKTVEKR ILMF-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >D_rerio_ENSDARP00000073959 ------------------------------------------------------------ -------------------------------------SDVKDSFKDGSLEGFSYFKKDEF ESDWEKLVERKFGRVYKVKLKVLRETCALKTTTNDYSLWPNRNIMEISKIGRMKFNYLIS IYGICKDPPALVMEYMRKGSLDNLLSNHLLMWPKKFQMIHEMTMGMNFLHSMKPPILHLN LKPANILLDDHLHVKISDFGFIKWEFSSKTEFIEHLMARGNINYVPPETLSQNPEPPGTK YDVYSFSIIMWEILTQKRSYAGKNNTPEILIRVSSGKRPGVEKIPEDKPPECEDMIGVMQ QCWNQDSRSRPPFSKTVRLTEVLSEVLKIPDTFSRREIRKRLPEQVCNEIKNEHQNGEDL QKIVQKKRKYPVSGSYVGSNALLMPEDVVEWEICIMNAQTTSLQQLRDAILSTWAEISGI DSIIRSLQF--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------VIGGCDKEIVVNFSKS LRYDSSIQSLLVRKD------FNSFKKV------------VRKEHVSMLFQDNNSLLHHA VAGGDRESVQMVLNL-------GASVNCQSVKGYTPLIVAVLHKFYEICSLLTDCGADVN LSDGDQWTALHFAVQ-AG--DDRATRFLLDNKA--------------------------- --------------------RADAKEKD------------------------------GW TPLHLAAQNGH---------------------------ENIVRILLRR-LDS--VDVQEH QSCRTALHVASIYGHINIVKLLL-NKGA--DIDKQDNNQSTALHLAAEEG----HFRVVR LLVNSGAD---------------------------------------------------- -----VNKVDE-QSYSSL----HFAALNGYTGICRLL----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LSKGIDPNSRTNKNWTAM HLAALKGHPEIILTLEEHQGSVNIQGKNGWTPLHLA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------CHHGQEEVVTGLLTAGADPNLAEDNGWTPLHLA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_aculeatus_ENSGACP00000011220 ------------------------------------------------------SLSLLR LQADAGNSFLRAARSGNLDKALDHIKNG--IDINTANQNGLNGLHLASKEGHVKMVLELL HNGIVLETTTKKGNTALHIAALAGQEQVVTELVNYGANVNAQSQK-----QKGFTPLYMA AQENHLEVVKFLLENGANQSIPTEDGFTPLAVALQQGHENVVALLINYGTKGKVRLPALH IAARNDDTRTAAVLLQNDPNPDVADM--------TG-FTPLHIAAHYENLNVAQLLLNRG ANVNFTPKNGITPLHIAARRGNVIMVR---LLLDRGAQIDAKTKDELTPLHCAARNGHVR IIEILLDHGAPIQAKTKNGLSPIHMSAQGDHMDCVKQL--LQYNAEIDDITLDHLTPLHV AAHCGHQRMAKVLLDKGAKPNSRALNGFTPLHIACKKNHMRVMDLLLKHSASIEAVTESG LTPLHVASF--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MG HLNIVKMLLQKGASPSASNV--KVETPLHMASRAGHHEVAEFLLKNAAPVDAKAKDDQTP LHCAARMGHKELVKLLLEHKANPNSTTTAGHTPLHIAAREGHAQTVRILLDMEAQQTKMT KKGFTPLHVASKYGK------VDVAELL-----------LERGANPNAAGKNGLTPLHVA VHHNNLDVVNLLVSK-------GGSPHSAARNGYTALHIASKQNQVEVANSLLQYGASAN AESLQGVTPLHLASQ-EG--RPDMVSLLISKQA--------------------------- --------------------NVNLGNKS------------------------------GL TPLHLVGQEGH---------------------------VGIADILVKQ-GAS--VYAAT- RMGYTPLHVACHYGNIKIVKFLL-QQQA--DVNSKTRLSYTPLHQAAQQG----HTDIVT LLLKHGAQ---------------------------------------------------- -----PNETTT-NGSSAL----SIAKRLGYISVIDVLKLVTEETVSMTT----TEKHRMS FPETVDEIL--DVSEDE----------------------GEELLGTEGARYMKMDDLK-D HDDDFLSPKKSLEN----------------------------YSPAIPRIPRVSPETVIL KEHAMD-QHTPLPLPKEYDDDSLIPSSPATETSDNVSPVASPIHTG------------FL VSFMVDARGGSMRGSRHNGLRVIIPPRTCAAPTRITCRLVKPQKLTSPPPLVEGEGLASR IISLGPAGMQ---------------------------------FLGPVIVEIPHFAALGR GDRELVVLRSENGSVWKEHRNRYGDEVLETILNGMDEELESQEELGKKRIRRIISTDFPL YFAVVSRVQQESDLIGPEGGLLLSKLVPLVQATFPETAVTKRVRLGL-QAQPVPDELVAK LLGNQANFSPVVTVEPRRRKFHRPIGLCIPLPPSW-RDSPRDS----GEGDTTSLRLLCS VIGGTAPAQWEDITGTTKLVYAKDSASFTTNVSARFWLADCPRTAEAVSFANLLYREL-- SAVPYMAKFVVFAKMNELREG---RLRCYCMTDDKMDKTLEQHENFTEVARSRDIEVMEG MPLHLECSGNLLPVRKATQQPRCFSFQAFRDNRLPVSVKVRDSSKEHTGFLSFLRKSTKY EDNQH--VLCNLNI-----------------TMPPCIKIAGSEDRRRTLTPLALRERYSA LNEPAMASMSA----MERTEVKMAVIAEQLGLSW-AELARELQLSVDDINKIRVEN-PNS LLEQSSALLNLWAAREGKRAKMESLY--AALKSIDRMDIVTMLEGQPPQPARQGSRDFTR RRNNRDN--VSPGMTNGYGLAQ-EELLSPASMQYSLPSPLGAEPYWQEVSSLDCAPIATT EEDTLMEMSDVQVWPSGNSPSLVPVEDSSLE-CSNADDSEGLLGLPYGSLGRPASQASAA SGGGGVLCGSIELPEDDSEMGVDSLSTATPASLGGTIAGINLNRLNNCQGSRASSEVSAV TSTAGGDGAGSEEGLSLVAGQQRVYARLSESPGLSCVADRNGDRSGNGGNGGGGGSFLSY LQEQTGPGWIPVTDPTQAWPVRDTGHSEMLRGHFRGTQPFEKGYRF----------LSGL TTAHRPPL-EKPSVFKAQRSHGQKEREREAITALTLTTMINPQGDEVEDLPGEHVSEEQF TDEHGNIVTKKIVRKVVRRGKGSGEEGVQEGSLEGSLQDANELEVDAEQFMSYAILGRES SKDSTTSPK---------------P >T_guttata_ENSTGUP00000010937 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------QPPLVQAIFSGDPEEIRMLIYKT EDVNALDAEKRTPLHVASFLGDADIIE---LLILSGARVNAKDNMWLTPLHRAVASRSEE AVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEILIPLLSSVNVSDRG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --GRTALHHAALNGH------IEMVNLL-----------LAKGANINAFDKKDRRALHWA AYMGHLEVVALLINH-------GAEVTCKDKKGYTPLHAAASNGQINIVKQLLNLGVEID EMNIYGNTALHIACY-NG--QDSVVNELIDYGA--------------------------- --------------------NVNQPNNN------------------------------GF TPLHFAAASTHG--------------------------ALCLELLVNN-GAD--VNIQS- KDGKSPLHMTAVHGRFTRSQTLI-QNGG--EIDCVDKDGNTPLHVAARYG----HELLIN TLITSGAD---------------------------------------------------- -----TAKCGI-HNMFPL----HLAALNAHSDCCRKL----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------LSSGQKYSIVSLFSNEHVLSAGFDIDTPDSFGRTCL HAAAAGGNVECIKLLQSSGADFNKKDKCGRTPLHYA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------AANCHFHCIET LVTTGANINETDDWGRTPLHYAAASDMDRNILPNHCNSHENAEELERATEMKEKEAALCL EFLLQNDANPSIQDKEGYNTVHYAAAYGHRQCLELLLEKTNNMFEESDSAATKSPLHLAA YNGHHQALEVLLQSLVDLDIKDDKGRTALDLAAFRGHAECVEALISQGASVTVKDNVTKR TPLHASVINGHTPCLRLLLEVTDNPDVTDAKGQTPLMLAVAYGHVDAVSLL--------- -------------------------------------------LEKEASVDAADLLGCTA LHRGIMTGHEECVQMLLEKEVSILCRDARGRTPLHFAAARGHATWLSELLQVALSEEDCS LKDNQGYTPLHWASYNGHENCIEVLLEQKLFHKFDGNSFSPLHCAVINDHENCASLLIGA IDASIVNCEDDKGRTPLHAAAFADHVECLQLLLSHSAQVNAADRAGRTPLMMAAHGGHLG AVDFLVNIAKADLTLKDKELNTSLHLASSKGHEKCALLILDKIQEQSLINAKNNALQTPL HIAARNGLKMVVEELLAKGACVLAVDENGHTPALACAPNKDVADCLALILATMMPFSPSS SVTAFNFACFK------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_nigroviridis_ENSTNIP00000018931 -----------------------------------------------------------L LQADAGNSFLRAARSGNLDKALEHIKNG--IDINTANQNGLNGLHLASKEGHVKMVLELL HNGIVLETTTKKGNTALHIAALAGQEQVVTELVNYGANVNAQS-------QKGFTPLYMA AQENHLEVVKFLLENGANQSIPTEDGFTPLAVALQQGHENVVALLINYGTKGKVRLPALH IAARNDDTRTAAVLLQNDPNPDVLSK--------TG-FTPLHIAAHYENLNVAQLLLNRG ANVNFTPKNGITPLHIASRRGNVIMVR---LLLDRGAQIDAKTKDELTPLHCAARNGHVR IIEILLDHGAPIQAKTKNGLSPIHMAAQGDHMDCVKQL--LQYNAEIDDITLDHLTPLHV AAHCGHHRMAKVLLDKGGKPNSRALNGFTPLHIACKKNHMRVMDLLLKHSASLEAVTESG LTPLHVASF--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MG HLNIVKILLQKGASPSASNVAQKVETPLHMASRAGHYEVAEFLLQNAAPVDAKAKDDQTP LHCAARMGHKELVKLLLDHKANPNATTTAGQTPLHIAAREGHVQTVRILLDMEAQQAKMT KKGFTPLHVASKYGK------VDVAELL-----------LERGANPNAAGKNGLTPLHVA VHHNNLDVVNLLVSK-------GGSPHSAARNGYTALHIASKQNQVEVANSLLQYGASAN AESLQGVTPLHLASQ-EG--RPDMVSLLISKQA--------------------------- --------------------NVNLGNKS------------------------------GL TPLHLVAQEGH---------------------------VAIADILVKQ-GAS--VYAAT- RMGYTPLHVACHYGNIKMVKFLL-QQQA--NVNSKTRLGYTPLHQAAQQG----HTDIVT LLLKHGAQ---------------------------------------------------- -----PNETTA-NGTSAL----AIAKRLGYISVIDVLKLVTEETVSMTT----TEKHRMS FPETVDEIL--DVSEDE----------------------GEELLGTEGARYMKMDDLK-D HDDDFLSPKKSLAN----------------------------YSPAIPRIPRVSPETVVL KEQDID-QHTPLPLPKEYDEDSLIPSSPATETSDNVSPVASPIHTG------------FL VSFMVDARGGSMRGSRHNGLRVIIPPRTCAAPTRITCRLVKPQKLTCPPPLVEGEGLASR IISLGPAGMQ---------------------------------FLGPVIVEIPHFASLSH GDRELVVLRSENGSVWKEHRNRYGDEVLETILNGMDEDLESQEELGKKRIRRIISTDFPL YFAVVSRVQQESDLIGPEGGSLASTLVPMVQATFPETAVTKRVRLGL-QAQPVPDELVAK LLGNQANFSPVVTVEPRRRKFHRPIGLRIPLPPSW-RESPRDS----GEGDTTSLRLLCS VIGGTAPAQWEDITGTTKLLYAKDCASFTTNVSARFWLADCPRTAEAVTFANLLYREL-- SAVPYMAKFVVFAKMNEMREG---RLRCYCMTDDKMDKTLEQHENFSEVARSRDIEVMEG MPLHLECSGNLVPVRKATQQPRCFSFQAFRDNRLPVTVKVRDSSKEPAALLSFLRKSTKY EDSQH--VLCNLNI-----------------TMPPCIKIIGGEDRRRTLTPLALRERYSA LNEPAMASMSA----MERTELKMAVIAEQLGLSW-AELARELQLSVDDINKIRVEN-PNS LLEQSSALLNLWATREGKRAKMESLY--MALKSIDRMDIVNVLEGQPPQPARQGPRDPSR RPHDREH--LSPGVTNGYGLAQ-EELLSPASMQYSLPSPLGSEPYWQEVSSLDCAPIATT EEDTLMEMSDVQVWPSGNSPSLVPVEDSSLE-CSNADDSEGLLGLPYGSLGRPASQASAA SGGGGLLSGSIELPEDDSEMGVDSLSTATPASLGGTIAGMNLNGLNNGQGSE-------- --------MGSAEGLSLVAGQQRVYARLSESPALGCVADRNIDRSGNGGN--GGGSLLAY LQEQTGQGWM--AEQTQAWPGSQNKARQAMDTMMSSVCNALDGEQIHISQEALIQPHPGQ TGANWGKLGQTGAVFKAHWSHDQSGR-----------------GEEVEDLPGEHVSEEQF MDEHGNIVTKKIVRKVVRRGKGAGEDGVQE--MEGSLQDANELELDPEQYMSYAVLGRDG SKPDSVDVKKGAQIVKCATLRRVKQ >T_nigroviridis_ENSTNIP00000020964 --------------------------------------------------------RSSH LQSDSNTSFLRAARAGNIDKVLDFLKNG--IDISTCNQNGLNALHLAAKEGHKDLVEELL DRGAPVDSSTKKGNSALHIASLAGQKEVVRLLVKRGANINSQS-------QNGFTPLYMA AQENHLEVVRYLLENDGNQSIATEDGFTPLAIALQQGHNSVVSLLLEHDTKGKVRLPALH IAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESG-FTPLHIAAHYGNVNVSTLLLNRG AAVDFTARNGITPLHVASKRGNTNMVA---LLLDRGAQIDAKTRDGLTPLHCAARSGHDQ AVEILLDRGAPILARTKNGLSPLHMSAQGDHIECVKLL--LQHQAPVDDVTLDYLTALHV AAHCGHYRVTKLLLDKKANPNVRALNGFTPLHIACKKNRVKVMELLVKYGASIQAITESG LTPIHVAAF--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MG HLSIVLLLLQNGASPDIRNI--RGETALHMAARAGQMEVVRCLLRNGALVDAMAREDQTP LHIASRLGKTDIVQLLLQHMAHPDAATTNGYTPLHISAREGQLETAAVLLEAGASHSLPT KKGFTPLHVAAKYGN------LDVAKLL-----------LQSKALPDDAGKNGLTSLHVA AHYDNQDVALLLLDK-------GASPHSTAKNGYTPLHIAAKKNQTKIASALLQYGAETN ILTKQGVSPLHLAAQ-EG--HTEMTGLLLDKGA--------------------------- --------------------HVNAATKS------------------------------GL TPLHLTAQEDK---------------------------VGAAEVLAKY-DAN--LDQQT- KLGYTPLIVACHYGNAKMVNFLL-QQGA--SVNAKTKNGYTPLHQAAQQG----NTHIIN VLLQHGAK---------------------------------------------------- -----PNTTTM-SGNTAL----SIARRLGYISVVDTLKVVTEEVITTTT--TVTEKHKLN VPETMTEVL--DVSDEE----------------------GEDTMTGDGGEYLRAEDLR-D LGDDSLP--GHYLDFSYMNNMNIDRWKSDKQTN---------KSQHTPIHQSFTQREGFF IEDMLT-SHQVSVLSKEHEKDSFRLSWGA-EHLDNVVLSSSLLHSGRSTPCLDHDNSSFL VSFMVDARGGAMRGCRHNGLRIIVPPRKCSAPTRVTCRLVKRHRLASMPPMVEGEGLAGR IIEVGPTGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRG TERELVILRSETGESWREHHCDFTEEELNQILNGMDEKLDSPEELEKKRICRIITRDFPQ YFAVVSRIKQDSHLIGPEGGVLSSTLVPQVQAVFPEGALTKKIRVGL-QAQPIDGDVVKK ILGNKAAFSAIVTLEPRRRKFHKPITMTIPIPKSPNTEGPTSE----FSGETPTLRLLCS ITGGTTPAQWEDITGSTPLTFVNHCVSFTTNVSARFWLIDCRQVQESVSFASQLYREI-- ICVPYMAKFVIFAKTLDPIEA---RLRCFCMTDDKMDKTLEQQENFTEVARSRDVEVLEG KPIFVDCFGNLVPLTKSGQH-HVFSFFAFKENRLALFIKIRDTAQEPCGRLSFTKEARTY RSLTH-NAICNLNI-----------------TLPAYSKESDSDQDGDDEKPLTSESR--- ------STDSQ----EESKEETLTIIADLLGFSW-TELAKELEFSENDIQSVRTDN-PNS LQEQSHALLQRWVEREGKHATEDCLI--KTLTKINRMDIVHLIETQMNKSVQ---EQTSR TYAEIEKT-----------LDH-SEDVEKVDRTLCLPEPKQSSQ------------IAES REKDFFDH------PRPESPHFASISFSLSPDHFRVSESTDSTGVL-----SPRSQIKDD TPRTGSLGKCKDTPHASTTAPKTNQSQSITQKAVSSTQAEGFLGPE-------------- -------------------SPQRLREVVEPSQNSEVYFESGEPESEEYED-------APF VQEPLRPGHEDSEERARSSEPSDDEFTLCEASQPPAACSAGD------------------ -----------------------------------RTDNCLPRADDFPEFATQSVTEEKY RDENGHIVVKKITRKIIRKCVSAEADREEV-------------------SFEGDAFAAQE EGGYPKVVKRTVLKSEGGHTESSNL