>H_sapiens_ENSP00000221740 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MSNPRSLEE-EKYDM--SGARLALILCVT-------------------KA REGSEEDLDALEHMFRQLRFEST-MKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLM AHG-RE-------GF-LKGE-------DGEMVKLENLFEALNNKNCQALRAKPKVYIIQ- -ACRG-------------EQR-DPGE---TVGGD------------------EIV----- ------------MVIKD--------------SP-QTIPTYTDALHVYSTVE--GY----- --------------------IAYRHDQKGSCFIQTLVDVFTK-----------RKGHILE LLTEVTRRMAEA--------ELVQEGKARKTNPEI-QSTLRKRLYLQ------------- ------- >M_mulatta_ENSMMUP00000024183 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MSNLRSSEE-EKYDM--SGARLALTLCVT-------------------KA REGFEEDLDALEYMFRQLRFEST-MKRDPTAQQFQEELEKFQQAIDSREDPISCAFVVLM AHG-RE-------GF-LKGE-------DGEMVKLDNLFEALNNKNCQALRAKPKVYIIQ- -ACRG-------------EQK-DPGE---TVGGD------------------EIV----- ------------MVTKD--------------SP-QTIPTYTDALHVYSTVE--GY----- --------------------IAYRHDQKGSCFIQTLVDVFTK-----------GKGHILE LLTEVTRRMAEA--------EMVQEGQAKKTNPEI-QSTLRKRLYLQ------------- ------- >C_familiaris_ENSCAFP00000023821 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MVDSEIRQAQLLAQ-EAYDM--SGARLALTLCVT-------------------KA REGSEADLDALERMFQQLGFEST-MKRDPTAQQFQEELDKFQQAMDARDDFISCAFVVLM AHG-LE-------GR-LKGE-------DGEMVELEDLFKVLNNKNCRALRAKPKVYIVQ- -ACRG-------------EQR-DPGE---TVSGD------------------DIV----- ------------MITKD--------------NP-QTIPTYTDILHVYSTVE--GY----- --------------------IAYRHDKEGSCFIQTLVDVFTE-----------RKGPILE LLTEVTRRMAEA--------ELVQEGKPRKVNPEI-QSTLRKRLYLQ------------- ------- >E_caballus_ENSECAP00000010379 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------Q-EAYDM--SGARLALTLCVT-------------------KA REGSEADLDALERMFQQLGFEST-TKRDPTAQQFQEELEKFQQAMDAREDLVSCAFVVLM AHG-VE-------GR-LKGE-------DEQMVELESLFEVLNNKNCQALKARPKVYIVQ- -ACRG-------------EQR-DPGE---TVGSD------------------DIM----- ------------MIAKD--------------SP-ETIPTYTDTLHIYSTVE--GY----- --------------------IAYRHDKEGSCFIQTLVDVFTE-----------RRGPILE LLTEVTRRMAEA--------ELVQEGRTRKVNPEI-QSTLRKRLYLQ------------- ------- >B_taurus_ENSBTAP00000028116 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ESKEMSSPQPLEE-ETYDM--SGARLALTLCVT-------------------KA REGSEADLDALERMFQQLGFEST-MKRDPTAQQFQEELEKFQQAIDAREDFVSCAFVVLM AHG-LE-------GR-LKGK-------DEKMVELEDLFQALNNKNCRALRAKPKVYIVQ- -ACRG-------------EQR-DPGE---PVTGG------------------HLV----- ------------MITEN--------------TP-ETIPTYTDTLHVFSTIE--GY----- --------------------IAYRHDQEGSYFIQTLVDVFIN-----------KKGPILE LLTEVTRRMAEA--------EMVQEGEAKKVNPEI-QSTLRKQLYLQ------------- ------- >O_cuniculus_ENSOCUP00000002346 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------ERYDM--SGARLALTLCVT-------------------KA REGSEADLDALERMFQQLGFEST-VKRDPTAQQFQEELEKFQQTIDAWKDPVSCAFVVLM AHG-DE-------GV-LKGE-------DEEMVKLEDLFEVLNNKNCKALRAKPKVYIVQ- -ACRG-------------EHR-DLGE---TVGED------------------QVM----- ------------MITRD--------------SP-QTIPTYTDTLHVYSTVE--GY----- --------------------IAYRHDQEGSCFIQTLTDVFMN-----------RTGPILE LLTEXXXXXXXX--------XXXQEGKARKVNPEI-QSTLRKRLYLQ------------- ------- >R_norvegicus_ENSRNOP00000009643 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MDSETINPQPLQE-ERYDM--SGARLALTLCVT-------------------KA REGSEVDMDALERMFQYLKFEST-MKRDPTAQQFLDDMDEFQQTIENWKEPVSCAFVVLM AHG-EE-------GF-LKGE-------DGNMVRLEDLFEVLNNKNCKALRGKPKVYIIQ- -ACRG-------------EHR-DPGE---ELPGD------------------ELA----- ------------VIKKK--------------NP-PTIPTYTDMIHIYSTVE--GF----- --------------------LSYRHDQKGSGFIQTLTDVFIH-----------KKGSITE LLEEITRLMANT--------EVMQEGKPRKVNPEI-QSTLRKKLYLQ------------- ------- >P_pygmaeus_ENSPPYP00000010831 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MSNLRSLEE-EKYDM--SGARLALTLCVT-------------------KA REGSEEDLDALEHMFQQLRFEST-MKRDPTAQQFQEELEKFQQAIDSREDPVSCAFVVLM AHG-RE-------GF-LKGE-------DGEMVKLENLFEALNNKNCQALRAKPKVYIIQ- -ACRG-------------EQR-DPGE---TVGGD------------------EIV----- ------------MVIKD--------------SP-QTIPTYTDALHVYSTVE--GY----- --------------------IAYRHDQK-------------------------------- ------------------------------------------------------------ ------- >M_musculus_ENSMUSP00000005488 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MESEMSDPQPLQE-ERYDM--SGARLALTLCVT-------------------KA REGSEVDMEALERMFRYLKFEST-MKRDPTAQQFLEELDEFQQTIDNWEEPVSCAFVVLM AHG-EE-------GL-LKGE-------DEKMVRLEDLFEVLNNKNCKALRGKPKVYIIQ- -ACRG-------------EHR-DPGE---ELRGNEELGGDEELGG-------DEV----- ------------AVLKN--------------NP-QSIPTYTDTLHIYSTVE--GY----- --------------------LSYRHDEKGSGFIQTLTDVFIH-----------KKGSILE LTEEITRLMANT--------EVMQEGKPRKVNPEV-QSTLRKKLYLQ------------- ------- >G_gorilla_ENSGGOP00000000424 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MSNPRSLEE-EKYDM--SGARLALTLCVT-------------------KA REGSEEDMDALEHMFRQLRFEST-MKRDPTAQQFQEELEKFQQTIDSREDPVSCAFVVLM AHG-RE-------GF-LKGE-------DGEMVKLENLFEALNNKNCQALRAKPKVYIIQ- -ACRG-------------XXX-XXXX---XXXXX------------------XXX----- ------------XXXXX--------------XX-XXXXXXXXXXXXXXXXX--XY----- --------------------IAYRHDQKGSCFIQTLVDVFTK-----------RKGHILE LLTEXXXXXXXX--------XXXXXXXXXXXXXXX-XXXXXKRLYLQ------------- ------- >M_domestica_ENSMODP00000018104 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------DVYNM--SDARLALTLCIT-------------------KN RAGSETDVQALEKMFKALNFKNT-VRRNIPAKGFWEELEKFRDDMDQMKDPVSCCFVVLM AHG-EE-------GI-LQGV-------DGNTIRLDELFCMLTNKNCRALRGKPKVFIVQ- -ACRG-------------DQK-DPGE---VVKPTSSG---------------GDV----- ------------LLAKE--------------RP-PKLPTFSDSLHVYATVE--GY----- --------------------IAYRHEEDGSFFIQTLVDVFTN-----------MKGNILD LLTEVTRRMADA--------ELMEEGKPRKVNPEV-QSTLRKLLYL-------------- ------- >O_anatinus_ENSOANP00000013840 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------LPHSSSSPQ-MVYDM--SGARLALTLCIT-------------------KD REGAEPDIAALERMYQALRFEST-VRRDPPAKAFRDELVRFREEMEGRKDPVSCCFVVLM AHG-KE-------GH-LLGA-------DEQVVELEELYDVLTNKSCRALLGKPKVFILQ- -ACRG-------------DQK-DSGE---MLRTE------------------EVL----- ------------TTMIQ--------------KV-PRIPTFTDTLHVYSTVE--GK----- --------------------GSHCH----------------------------------- ------------------------------------------------------------ ------- >M_domestica_ENSMODP00000020556 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------LLLWLPQLSPIPQ-GVYDT--SGAKVALVLCVT-------------------RD RPGAKQDLKALKRLFQTLGFKSI-LKMNPTAQDFRKELTRFRELLDARRTNVSCALVALM AHGEPQ-------GR-LLGA-------DGQMVEVEEMVSELS--ACQVLQGKAKVVLLQ- -GCRG-------------GNR-DPGM-----RPRALPWLG------------SWL----- ------------QHWLQ--------------RP-STIPSHADILQVYANLQ--GY----- --------------------VAYRN-ENGSDFIQTLVQVIIA-------N---PDQDLLE LLTEVNKRLCEM------EVRGPDCDEIRKMSVEI-QSSLRKQLYLK------------- ------- >E_caballus_ENSECAP00000006138 ------------------------------------------------------------ ------------------------------------------------------------ -----------------ELAEEGGLGSGLPWGAGWLPGAAGCPWGPCGLCPSGL-APSGL LRQPQQLVQELSRCGALRGCPKVFLLLSSAPGAAPEPGAFLTSLGELCGRCPHWSLLQLL TEVFCRIAEEFSGATYCPVLRSSLR----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G ALCLGDTEPWGLEPEPSPS-AQYDL--SGARVALLLAVI-------------------RG RSGAQHDVEALWGLCQALGFETT-LMTDPTAQAFQEELAQFREWLDAHRGPVSCALVALM AHGGPQ-------GQ-LLGA-------DGQEVQPEALVRELS--CCRALRGRPKIFLLQ- -ACRG-------------GHR-DAGL-----GPTAL----------------SWF----- ------------WRWLR--------------AP-PATPSHADVLQVYADAQ--GSSSRGP TAGSSDQADILMVYAAAEGCVAYRD-ETGSDFIQTLVEVLRA-------D---PKGDLLE LLTEVNRRVCEL------DVLGPDSDERRKACLEI-RSSLRRRLCLQA------------ ------- >M_mulatta_ENSMMUP00000027593 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------APGPN-TQYDL--SKTRAALLLAVI-------------------QG RPGAQHDVEALGGLCRALGFETT-VRTDPTAQAFQEELAQFQKQLDTCRGPVSCVLVALM AHGGPQ-------GQ-LLGA-------DRQEVQPEALMQELS--RCRVLWGRPKVFLLQ- -ACRG-------------GNR-DAGV-----GPTAL----------------PWY----- ------------WSWLR--------------AP-PSVPSHADVLQIYAEAQ--GY----- --------------------VAYRD-DKGSDFIQTLVEVLRA-------N---PGRDLLE LLTEVNRRMCEQ------DVLGPDCDELRKACLEI-RSSLRRRLCLQP------------ ------- >B_taurus_ENSBTAP00000045524 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------VEPWGPEPEPGPS-AQYDL--SGARAALLLAVT-------------------QG RLGAQHDVEALEGLCQALGFETT-LRTDPTAQTFQEEMAQFRKRLDAHRGPVSCALVALM AHGGPQ-------GQ-LLGA-------DGQERQLEVLVQELS--HCGALRGRPKIFLLQ- -ACRG-------------GEQ-APGP---PWRPASCCPSSPHPALSLSGLVVHLL----- ------------QRWLR--------------AP-PATPSQADVLHVCTDVQ--GC----- --------------------VAYRD-KKGSDFIQTLVEVLRA-------D---PKADLLE LMTEVNRQVCEL------DVLGPDCDDRRKACLEI-RSSLRRRLCLQ------------- ------- >B_taurus_ENSBTAP00000012869 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------MEGSLGSGRRSGSDGQPAPPKISPTTEELQSRLQETLDLLSSQELRSFR DHLKKV--EPPVSQVKLELEGHSPSGLAKLLAKHYYPAAVAKRVLVQVLELLPR------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------ADLLPRWQ-SAPTD---C PVIPRKSLKRSYDCVDGEL-YRYDL--SGRRKAFLMCVK-------------------KN RLGAHQDVQLMKDWLKECKFEPT-LCIDPDKMDLLGKITSFRDELNEIKDDIGCCLVTLM SHG-EE-------GF-IKMK-------DGEKVSLEDIFEMFNNKNCPALQEKPKIFIIQ- -ACRG-------------ERR-DSGV-----ETDDE----------------PMD----- ------------LDDGS--------------EK-KRLPTFSDYFIVYPTQA--DH----- --------------------VALRDPRTGSVMIKEMTEVFKQ-------YG--NKWHLAD FFTIVNNRVVHR--------DFNLCNKPVKVSLVM-ESTLTKFVYF-------------- ------- >M_domestica_ENSMODP00000032734 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------MLQPDMESFKAQVVSTLTKLSPEELRRFG IYLRNVGEEPRVSRHDLEM-ATKPEELADLLLKRYVMTG-TPRVLVQVLGQVPR------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KDLALEWALRRRSPSR---C KSMSRMNLKRPYEDDSSEL-DRYNM--DRTRKAFVMCVK-------------------TG RPGAKQDISRIKNWLEKCKFEYT-YCDDPDEEELFEKLTQFRDGINGIKEEVSCCLVTLM AHG-GK-------GH-IKTK-------SNERVNLSDIFEMFNNENCPALQEKPKIFVIQ- -ACRG-------------DKR-DGGV----VQADDE----------------PM------ ------------ELDLS--------------EK-KRLPTSSDYYIIYATQD--DH----- --------------------VAFRHPRDGSVMIQAIDEVFRQ-------HG--KKWHIAD FFTQVNNLVVHT--------DFYINRNPAKVVLVM-ESTLTKAVYF-------------- ------- >C_familiaris_ENSCAFP00000007585 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------MERSPGSGGRWECSGPPAPPELTPDVAELQSRVQETLELLSPQDLRNFR LLLKTVDEEPRVSPVKLELEGRKKAGLARLVAQNYCEPA-ASRVLVKVLRQLRR------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------ADLLRLWQGAADRG---G ERIPRKILKRSYDCVDGEL-DRYDL--SGSRKAFLMCVE-------------------KS RPGAHRDIELMKEWLGQCQFEHT-ACIDPNKMELLRKITLFRDGLNEIKGDVGCCLITLM SHG-EN-------GF-IKME-------DGEKVNLQDIFEMFNNKNCPALQEKPKIFIIQ- -ACRG--------VLQNTERR-DSGV-----ETDDE----------------PME----- ------------SDDVS--------------EK-RRLPTFSDYFIIYPTQA--DH----- --------------------VALRHPRTGSVMIEAMSEVFKQ-------YG--NKWHIAD FFTRVNNRVVHT--------EFHLHEEPIKVSLVM-ESTLTKSVYF-------------- ------- >O_cuniculus_ENSOCUP00000000197 ------------------------------------------------------------ ------------------------------------------------------------ -----------------ELGEEGGLGPGLPPGASFVQEAAGCPPEPRGLCPCGPGAPRGQ LRQPRQLVQELSCCEALQGCPKVVLLLSSGAGAALEPGAFLAGLRELCGRRPHWSLLQLL TELFCRVAEDSAGDIRCPVFQSSLR----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G ALCLTSEEPWRPEAEPGPG-AQYDM--SGARAALLLAVI-------------------RD RPGAERDVEALGGLCQALGFETT-LRTDPTAQAFWEKLGQFQEQLDTYRGPVSCALVALM AHGGPQ-------GQ-LLGA-------DGQEVQPEALVQELN--PCGALSGCPKVFLLQ- -AWRG-------------GNR-DAGK-----GPKAL----------------PWY----- ------------RRWLW--------------VPQPALPSHADVLQVHADAQ--GSSCSGP APGSSGQADVLTVYAAAEGCVAYRD-EMGSDFIQTLVDVLRA-------D---PGRDLLE LLTEVNRRVCEL------DVLGPDCDEPRKACLEI-RSSLRRRLRLRV------------ ------- >A_carolinensis_ENSACAP00000013788 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------DHYGM--KKKRVAFMMCVT-------------------EG RAGAEEDIKKMKKWFRTFKFTLLGDCRNPGQETLMQQLRQFRDIINLSNEEISCCLITLM SHGKAN-------GY-ILDK-------DNREISLDGIFSLFNNKTCPKLQGKPKIFIIQ- -ACRG-------------EQR-DYGT----LVAGGK----------------PV------ ------------EPDTW--------------SR-PKLPTVSDYFIVYSSQR--DH----- --------------------IAVRDENTGSEMISAMDEVFSE-------HG--TQWHIGD LFTKVNSKMIQR------DFHLEGEEESVKVTIVM-ESTLTKALYL-------------- ------- >O_anatinus_ENSOANP00000019254 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----IDSPMCHPSPGDENQ-KRYDM--SKCREAFLMGVK-------------------KG RSGATEDIEKLRKHLAAFRFSVQ-ECIDPDGKVILQDLREFRDKINGSPYEMSCCLVILM SHG-VN-------GF-IKGK-------DEKVVDLEEIFKLFNNANCPNLREKPKIFIIQ- -ACRGGPNHRSRGIKSKIDRT-DGGV----EAFDNV----------------PEE----- ------------MDDTS--------------NV-KRLPTTSDFFIVYSTQK--GH----- --------------------VSVRNPLMGSRMIEAMDDVFSR-------YG--KKWQLTD LFTKSLLKALPS----------LLEGGIVKVTLEM-QSTLTRAVYLG------------- ------- >E_caballus_ENSECAP00000017996 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------VK-------------------RN RPGAQHDVMLMKEWLGQCQFEHT-SCIDPDKMELLGKITSFRDGLNEIKDEIGCCLVTLM SHG-EN-------GF-IKMK-------DDERVSLEDIFEMFNNKNCPALQEKPKIFIIQ- -ACRG-------------EKR-DSGV-----ETDDE----------------PMD----- ------------SDDIS--------------EK-RRLPTFSDYFIIYPTQA--DH----- --------------------VALRHPRTGSVMIEAMAEVFKQ-------HG--NRWHIAD FFTRVNNRVVHT--------EFHLREEPIKVSLVM-ESTLTKSVYF-------------- ------- >T_guttata_ENSTGUP00000006879 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --MTDIGDGAHLGKDLA-------D-----TKS--------------IPGFK-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GKNLP---A SKSMDS--------GILPD-YSYRM--DYPEMGECIIINNKNFH--RYT-------GMSP RSGTDADAASVREVFMKLGYKIK-INNDLSCEGIFNLLKNV-SEED--HSKRSSFVCVLL SHG-DE-------GL-IYGT-------DG-PLELKALTSLFRGDRCRSLAGKPKFFFIQ- -ACRG-------------TEL-DSGI-----ETD-S-----GS----------------- --------------EET--------------MC-QKIPVEADFLYAYSTAP--GY----- --------------------YSWRNSAEGSWFIQSLCKMLKE-------HA--RKLELMQ ILTRVNRRVA-E---YESCS-TRQDFNAKKQIPCI-VSMLTKEFYF-PS----------- ------- >A_carolinensis_ENSACAP00000006831 ------------------------------------------------------------ ------------------------------------SRMLGVCGMQKCHQEALKKNRVSL AKQLVLKELMEHLIEKDV------------------------------------------ ----------------------ITEEMMEMIQAKAGNFSQNIEFLNLLPKRGPKAFSAFC EALRETKQPHLEEMLLL-------N-----LIDFLLFH---------------------- -----------------------------------------HVIVPPQNAHLPLH----- -----------TVCDLL--------------PFAYQLFISSAEPMEH------------- ------------------------------------------------SLDDGDGP---H YPQ--VMPCTPEFYRTHEQ-LAYKL--KSQPRGLALILSNIHFN--KET-------DLDF RSGGDVDNTALHMLFKHLGYQVV-VRQDRTAQEMKEELEIFSKHPA--HRNVDSCIVSLL SHG-IE-------GG-IYGI-------DGKLLQLQEIFRLFDNANCPNLQNKPKMFFVQ- -ACRG-------------DET-DHGV----DQIDGNDRASSPGCE-E-----TDA----- ------------NKKEN--------------PK-LRLPTCSDMICGYACLK--GT----- --------------------AAMRNTKHGSWYVEALTSVFAE-------DS--GHMHVAD MLVKVNRLIKLR----EGHA-PGTEFHRCKEMSEY-CSTLCQDLYLFPGYFPG------- ------- >O_anatinus_ENSOANP00000000517 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------AASGEVMV-------D-----SKS--------------FHSSQGY------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SSRKVP---G KQFLGS--------SASLD-DRYRM--DYPNMGICLIINNKNFH--PDT-------RMGC RSGTDVDAASLRDTFKKLKYEVR-CKNDLKRREILELLTSV-AHED--HSKRSSFVCVLL SHG-EE-------GV-IFGT-------DG-SLELKSLASLFRGDNCRSLVGKPKLFIVQ- -ACRG-------------TEL-DSGV-----EAD-S-----SS----------------- -------------ADDG--------------SE-QKIPVEADFLYAYSTAP--GY----- --------------------YSWRNSMNGSWFIQALCAMLKQ-------HA--HTLELLH ILTRVNRKVATE---FESYS-LDATFNAKKQIPCI-VSMLTKELYF-PY----------- ------- >T_guttata_ENSTGUP00000013612 ------------------------------------------------------------ --------------------------------------MLAACGMQRCHQEALKKNRVML AKQLVLNVLVEHMVEKDI------------------------------------------ ----------------------IPTEMVEMIQAKSGSFDRNVEFLNLLPKRGPNAFSAFC EALRETQQQHLETLILK-------T-----MSS--LSQ---------------------- ---------------------------------------EIARLEHCHESDLPYP----- ---------ASESCNSK--------------RPRWL------EPMEH------------- ------------------------------------------------SLDNRDGP---S IPP--VKYCTPEFYHNHQH-LAYKL--TSEPRGLALILSNVRFS--SEK-------DLEY RAGGDVDCASLEMLFRHLGYRVT-VFCDQTAQDMQNALERFSKLQD--HRDVDSCIIALL SHG-VE-------GG-VYGS-------DGKLLELQETFRLFDNANCPNLQNKPKMFFIQ- -ACRG-------------DEL-DRGV----DQRDGKGRSDSPGCE-E-----SDA----- ------------NKEES--------------LK-LRLPTCSDMICGYACLK--GT----- --------------------AAMRNTKRGSWYVEALTSVFAE-------DS--QHTHVAD MLVKVNRQIKQR----EGYA-PGTEYHRCKEMSEY-CSTLCRDLYLFPGYLPGK------ ------- >M_domestica_ENSMODP00000005556 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MEDTGTTV-------D-----AKS--------------TKNSG-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------VKLFH---G SKSVES--------GLS-S-DSYKM--DYPEMGLCIIINNKNFH--PNT-------GMSF RSGTDVDAASLSDTFRSLKYEVR-IKNDLTCNEITELLNSV-SKED--HSQRSSFICVIL SHG-EE-------GV-IFGT-------DR-SVELKRLTCFFRGDKCRSLTGKPKLFIIQ- -ACRG-------------TEL-DCGV-----ETD-S-----GT----------------- -------------DEDI--------------AC-QKIPVEADFLYAYSTAP--GY----- --------------------YSWRNSKDGSWFIQALCAVLKQ-------HA--HKLEIMQ ILTRVNRKVATE---FESYS-LDISFHAKKQVPCI-MSMLTKELYF-SH----------- ------- >G_gallus_ENSGALP00000029853 ------------------------------------------------------------ ----------------------------------------GACGMQRYHQEALKKNRVML ARELVLKELMEHMIEKDI------------------------------------------ ----------------------ITIEMVEMIQAKSGSFSQNVEFLNLLPKRGPNAFSAFC EALQETKQQHLAEMILK-------T-----ESS--LRH---------------------- ---------------------------------------GIATLEQRYGSNLPLP----- ---------LSESCNSK--------------RPRLIVFFCT-KPVEH------------- ------------------------------------------------SLDSGDGP---P IPP--VKHCTPEFYRDHQH-LAYKL--ISEPRGLALILSNIHFS--SEK-------DLEY RSGGDVDCASLELLFKHLGYQVT-VFHDQSAEEMESALERFSKLPD--HQDVDSCIVALL SHG-VE-------GG-VYGT-------DGKLLQLQEAFRLFDNANCPNLQNKPKMFFIQ- -ACRG-------------DET-DRGV----DQRDGKEWSDSPGCE-E-----SDA----- ------------NKEEN--------------LK-LRLPTRSDMICGYACLK--GT----- --------------------AAMRNTKRGSWYIEALTTVFAE-------DS--RDTHVAD MLVKVNRQIKQR----EGYA-PGTEFHRCKEMSEY-CSTLCRDLYLFPGYVPGK------ ------- >A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------PT-FRYRM--DYKKLGKCVIINNKNFA--KDT-------GMRI RNGTDKDAGDLQKCFRGIGFDVS-IYNDLTCDNMEKILGEA-ALEN--HDDAACFACILL SHG-EE-------GL-IYGT-------DG-CMAIKNLTGLFRGDKCQSLIGKPKLFFIQ- -ACRG-------------SEF-DAGI-----QTD-S-----GSSN-DNL----------- ------------EMDAN--------------PR-YKIPVEADFLYAYSTVP--GY----- --------------------FSWRNPGKGSWFVQSLCSVLND-------HG--KELEVLQ ILTMVNYKVARN---YESQS-DDPRFSQKKQVPCV-VSMLTKELYF-------------- ------- >G_gallus_ENSGALP00000017288 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -MMTDIKDGPRSGEDVS-------D-----ARS--------------FPGSK-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GMNLP---A SKSVDS--------GILPD-DSYRM--DYPEIGVCVIINNKNFH--RDT-------GLSS RSGTDADAASVREVFMKLGYKVK-LNNDLSSRDIFKLLKNV-SEED--HSKRSSFVCVLL SHG-DE-------GL-FYGT-------DG-PLELKVLTSLFRGDKCRSLAGKPKLFFIQ- -ACRG-------------TEL-DSGI-----EAD-S-----GP----------------- --------------DET--------------VC-QKIPVEADFLYAYSTAP--GY----- --------------------YSWRNAAEGSWFIQSLCRMLKE-------HA--RKLELMQ ILTRVNRRVA-E---YESCS-TRQDFNAKKQIPCI-VSMLTKEFYF-PC----------- ------- >X_tropicalis_ENSXETP00000015203 ------------------------------------------------------------ ----------------------------------------MLGGMQKHHKDALQRLRVTL LHDMIIEELVEHLVSSGI------------------------------------------ ----------------------LTPIMHSTIMAHRSEYKQNVTLLTQLPKRGPRAFSEFC NALHATGQRHLAEQLEE-------E-----AQQQQME----------------------- -----------------------------------------SVTPEVHERSFPLP----- ---------VQEST-----------------PSRPRRQFCR-EYNEE------------- ------------------------------------------------SIDDGDGP---G T----VQLCSVDFYLSHHQ-QAYKM--HSCPRGRALIISNVAFE--TQ--------DLDH RYGGEVDVTSLEKLFSSLGFQVE-VRRNLNAQNMMSQLGAFSALPA--HSALDSCVVAVL SHG-LD-------GA-VYGT-------DGKLVQLQDVFTAMDNAHCPQLQNKPKMFFIQ- -ACRG-------------EEA-DRGV----DQRDGREQSASPGCE-Q-----SDA----- ------------GRED---------------IK-VRLPTQSDMICAYACLK--GT----- --------------------VSLRNTKRGSWFVQDLVSVFSQ-------YS--KNTHVAD MLVKVNALIKER----EGHA-PGTEFHRCKEMSEY-CSTLCRDLYLFPG----------- ------- >M_domestica_ENSMODP00000001598 ------------------------------------------------------------ -------------------------------------RMLGVWGMEQEHQEALKKNRVVL AKQLLLSELLEHLLEKDI------------------------------------------ ----------------------ITLEMRELIQAKVGSFSQNVEFLNLLPKRGPHAFEAFC DALRETKQGHLEDLLHR-------T-----LYS--FQN---------------------- ---------------------------------------LRPPLGCDYDSSFPLP----- ---------VCDSC-----------------PPHKQLRLSV-ETMEH------------- ------------------------------------------------SLDNGDGP---P SLQ--VKPCTPEFYQTHQH-LAYRL--QSRPRGLAMVLSNVHFN--GEK-------DLEF RSGGDVDHSSLVTLFKLLDYDVH-VLRDQTAQKMQENLQRFAQLSA--HQSTDSCMVALL SHG-IE-------GG-IYGV-------DGKLLQLQEVFRLFDNANCPNLQNKPKMFFIQ- -ACRG-------------DET-DRGV----DLRDGKEHVASPGCE-E-----SDA----- ------------GKEKI--------------LK-MRLPTRSDMICGYACLK--GT----- --------------------AAMRNTKRGSWYIEALTQVFSE-------RA--RDMHVAD ML--VNALIKDR----EGYA-PGTEFHRSKEMSEY-SSTLCRHLYLFPGHPPT------- ------- >D_rerio_ENSDARP00000024255 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------EQYEM--KGERRGVCLIINNYDFS--AC--------GWLN REGTDIDHDSLRDVFEWLGFEIL-TRRDCTGDQILQALMDL-STQD--HTQADCVVCCIL SHG-RL-------ND-IIGV-------DGKAVPFKELMETLSPFRCSSLYQKPKLFFIQ- -ACRG-------------TQN-QRAV---FPQTF-T-----EDED-VL----A-S----- ------------D-AGV--------------PR-DSIPEMADYLMAMSTVP--WY----- --------------------ASYRDKSKGTWFIQSLCDNLRL-------LVP-RGNDLLS ILTKVNADVSKK--------SD--KSGLKKQMPQP-EFSLTRTVVF-PPPGLP------- ------- >R_norvegicus_ENSRNOP00000014096 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MDNNETSV-------D-----SKS--------------INNFE-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TKTIH---G SKSMDS--------GIYLD-SSYKM--DYPEMGLCIIINNKNFH--KST-------GMSA RNGTDVDAANLRETFMALKYEVR-NKNDLTREEIMELMDSV-SKED--HSKRSSFVCVIL SHG-DE-------GV-IFGT-------NG-PVDLKKLTSFFRGDYCRSLTGKPKLFIIQ- -ACRG-------------TEL-DCGI-----ETD-S-----GT----------------- -------------DDDM--------------AC-QKIPVEADFLYAYSTAP--GY----- --------------------YSWRNSRDGSWFIQSLCAMLKL-------YA--HKLEFMH ILTRVNRKVATE---FESFS-LDATFHAKKQIPCI-VSMLTKELYF-YH----------- ------- >G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------M---D KLYRDV-------QSGEDK-YRYKM--DYPCMGTCVIINIKNFD--LKT-------GLET RNGTDVDAAELEKTFSKLGYKVT-LVHDQTADQIVDLLRDV-STQD--HSNSGSFVCVLL SRG-DE-------GG-IYGT-------DGSFVNLDELTKFVDGNGCRSLVGKPKLLFIQ- -AARG-------------NKL-DDGT-----LSE-G-----DS----------------- -------------MDGQ--------------TP-SRIPVEADFLYAYSTTP--GF----- --------------------NAWRDTQNGSWFMQSLCEMLRR-------FS--GQLELMQ IMTRVNNKVALE---YKTT----PGRSGKRQMPCI-VSLLTKEFYF-P------------ ------- >M_musculus_ENSMUSP00000031895 ------------------------------------------------------------ -------------MAAPSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQETLKKNRVVL AKQLLLSELLEHLLEKDI------------------------------------------ ----------------------ITLEMRELIQAKGGSFSQNVELLNLLPKRGPQAFDAFC EALRETRQGHLEDLLLT-------T-----LSD--IQH---------------------- ---------------------------------------VLPPLSCDYDTSLPFS----- ---------VCESC-----------------PPHKQLRLST-DATEH------------- ------------------------------------------------SLDNGDGP---P CLL--VKPCTPEFYQAHYQ-LAYRL--QSQPRGLALVLSNVHFT--GEK-------DLEF RSGGDVDHTTLVTLFKLLGYNVH-VLHDQTAQEMQEKLQNFAQLPA--HRVTDSCVVALL SHG-VE-------GG-IYGV-------DGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQ- -ACRG-------------DET-DRGV----DQQDGKNHTQSPGCE-E-----SDA----- ------------GKEEL--------------MK-MRLPTRSDMICGYACLK--GN----- --------------------AAMRNTKRGSWYIEALTQVFSE-------RA--CDMHVAD MLVKVNALIKER----EGYA-PGTEFHRCKEMSEY-CSTLCQQLYLFPGYPPT------- ------- >O_anatinus_ENSOANP00000005545 ------------------------------------------------------------ --------------------------------------------MQPCHQEALKKNRVAL AKQLMLSELLEHLLEKDV------------------------------------------ ----------------------ITMEMRELIQAKAGSFSQNVEFLNLLPKRGPKAFDAFC AALRETKQGHLQDLLYR-------T-----LSN--LSPPSTAVGALGTQGEE-------- ---------------------------------------LAGRLGGRWRGLPSLP----- ---------SVSVCPVVVCPFLMVLGNSRLQPALSVGDLLP-EEMEH------------- ------------------------------------------------SLDNGDGP---P CPQ--VKPCTPEFYRVHHH-LAYRL--ESRPRGLALVLSNMRFN--GEK-------DLEF RSGGDVDHNALITLFKHLDYSVE-FLRDQTAQEMQEKLHNFAQSPR--HRFTDSCVVALL SHG-VE-------GG-IYGV-------DGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQ- -ACRG-------------DET-DRGV----DQRDGKERAASPGCE-E-----SDA----- ------------GKEEM--------------LK-VRLPTRSDMICGYACLK--GT----- --------------------AAMRNTKRGSWYIEALTQVFAE-------SA--RDMHVAD MLVKVS------------------------------------------------------ ------- >B_taurus_ENSBTAP00000021099 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MENTENSV-------D-----SKS--------------IKTSE-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TKILH---G SKSMDS--------GISLE-ESYKM--DYPEMGLCIIINNKNFH--ENT-------GMCR RSPTDDSVAQXRETFMNLKYEVR-IKNDLTCKEMLELMSNV-SKED--HSKRSSFICVLL SHG-EE-------GI-IFGT-------NG-PVNLKKLASFFRGDYCRSLTGKPKLFIIQ- -ACRG-------------TEL-DCGI-----ETD-S-----GA----------------- -------------EDDM--------------AC-QKIPVEADFLYAYSTAP--GY----- --------------------FSWRNAKNGSWFIQALCEMLKK-------HA--HRLELMH ILTRVNRKVAIE---YESFS-TDSAFHAKKQIPCI-MSMLTKELYF-------------- ------- >R_norvegicus_ENSRNOP00000022672 ------------------------------------------------------------ -------------MAASSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQETLKKNRVVL AKQLLLSELLEHLLEKDI------------------------------------------ ----------------------ITLEMRELIQAKGGSFSQNVELLNLLPKRGPQAFDAFC EALRETRQGHLEDLLLT-------T-----LSD--IQH---------------------- ---------------------------------------ILPPLSCDYDSSLPFS----- ---------VCESC-----------------PPHKQSRLST-DTMEH------------- ------------------------------------------------SLDNGDGP---P CLQ--VKPCTPEFYQAHYQ-LAYRL--QSQPRGLALVMSNVHFT--GEK-------DLEF RSGGDVDHTTLVTLFKLLGYNVH-VLYDQTAQEMQEKLQNFAQLPA--HRVTDSCIVALL SHG-VE-------GG-IYGV-------DGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQ- -ACRG-------------DET-DRGV----DQQDGKNHAQSPGCE-E-----SDA----- ------------GKEEL--------------MK-MRLPTRSDMICGYACLK--GN----- --------------------AAMRNTKRGSWYIEALTQVFSE-------RA--CDMHVAD MLVKVNALIKER----EGYA-PGTEFHRCKEMSEY-CSTLCQQLYLFPGYPPT------- ------- >P_pygmaeus_ENSPPYP00000017020 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MENTENSV-------D-----SKS--------------IKNLE-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PKVIH---G SKSMDS--------GISLD-NSYKM--DYPEMGLCIIINNKNFH--KST-------GMAS RSGTDVDAANLRETFRNLKYEVR-NKNDLTREEIVELMRDV-AKED--HSKRSSFVCVLL SHG-EE-------GI-IFGT-------NG-PVDLRKITNFFRGDRCRSLTGKPKLFIIQ- -ACRG-------------TEL-DCGI-----ETD-S-----GV----------------- -------------DDDM--------------AC-HKIPVEADFLYAYSTAP--GY----- --------------------YSWRNSKDGSWFIQSLCAMLKQ-------YA--DKLEFMH ILTRVNRKVATE---FESFS-LDATFHAKKQIPCI-VSMLTKELYF-YH----------- ------- >M_musculus_ENSMUSP00000091238 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MENNKTSV-------D-----SKS--------------INNFE-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------VKTIH---G SKSVDS--------GIYLD-SSYKM--DYPEMGICIIINNKNFH--KST-------GMSS RSGTDVDAANLRETFMGLKYQVR-NKNDLTREDILELMDSV-SKED--HSKRSSFVCVIL SHG-DE-------GV-IYGT-------NG-PVELKKLTSFFRGDYCRSLTGKPKLFIIQ- -ACRG-------------TEL-DCGI-----ETD-S-----GT----------------- -------------DEEM--------------AC-QKIPVEADFLYAYSTAP--GY----- --------------------YSWRNSKDGSWFIQSLCSMLKL-------YA--HKLEFMH ILTRVNRKVATE---FESFS-LDSTFHAKKQIPCI-VSMLTKELYF-YH----------- ------- >O_anatinus_ENSOANP00000015596 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------AGTRRDQARQLVTDLETRGRRALSVFI SCLRETDQHALAALLSE-------G-----CQAPQVTPV--DIRPVE----IIR------ --------------------------------PGGQGDVCKYSKIHPKCYSPPLPFQSTS PLRGKEQWTGSVKPFVPVPS---------------------------------------- ---------------------------------------------------TTKRE---Q EATR--PGE----KQGMAI-KVYSL--KSEPCGHCLIINNVDFS--LGS-------GLST RTGSDVDCEKMKRRFRLLHFEVA-VERNLTAEEMVKALNKL-AKKD--HSALDCCVVVIL SHG-YQASHIQFPGG-IHGT-------DGESISVETIVNYFNGSRCPSLGGKPKLFFIQ- -ACGG-------------EKK-DPGF---EVNLDSP-----EDHP-TG----SDPESDAA PFQAAPED----YDEPD--------------AV-ASLPTPSDILVSYSTFP--GF----- --------------------VSWRDTQSGSWYIETLDSVLDQ-------WA--HTEDLLT LLLRVSNGVSSK--------------GKYKQIPGC-FNFLRKRLFFNTK----------- ------- >M_mulatta_ENSMMUP00000016588 ------------------------------------------------------------ -------------------------------------RILGVCGMHPHHQETLKKNRVML AKQLLLSELLEHLLEKDI------------------------------------------ ----------------------ITLEMRELIQAKVGSFSQNVELLNLLPKR-PQAFDAFC EALRETKQGHLEDIELK-------L-----RVS--ALM---------------------- ---------------------------------------KPTGLGSDYNDILGLM----- ---------VKLNT------------------VFWFSVYTT-DTVEH------------- ------------------------------------------------SLDNKDGP---V CLQ--VKPCTPEFYQTHFQ-LAYRL--QSRPRGLALVLSNVHFT--GEK-------ELEF RSGGDVDHSTLVTLFKLLGYDVH-VLRDQTAQEMQEKLQNFARLPA--HRVTDSCIVALL SHG-VE-------GA-IYGV-------DGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQ- -ACRG-------------DET-DRGV----DQQDGKNHAGSPGCE-E-----SDA----- ------------GKEKL--------------PK-MRLPTRSDMICGYACLK--GT----- --------------------AAMRNTKRGSWYIEALAQVFSE-------RA--CDMHVAD MLVKVNALIKDR----EGYA-PGTEFHRCKEMSEY-CSTLCRHLYLFPGHPPT------- ------- >D_rerio_ENSDARP00000071815 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MSDVKPKGVDTV-------D-----ARQ--------------SDAKESS------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SVTDP---G LVQMDAKSH----SDDNVD-YQYKT--NYPNLGQCLIINNKNFH--KRT-------GMGV RNGTDEDAKKVFETFSQLGFKVG-HYNDLTVSQMMALLNKA-SQED--HSKSAMFACVLL SHG-DD-------GL-IYGT-------DN-SIELKRLFAHFRGDRCTSLVGKPKLFFIQ- -ACRG-------------TDL-DSGI-----ECD-G------------------------ -------------VGDE--------------ET-QRIPVEADFLYAYSTAP--GY----- --------------------YAWRNVANGSWFISSLCDMLLK-------YG--KQLEIMQ VMTRVNHKVALE---FESSS-NLPGFDGKKQIPCI-VSMLTKELYF-PK----------- ------- >D_rerio_ENSDARP00000083664 ------------------------------------------------------------ --------------------------------------MLGECGMTKWERLALRRNSVKM LQDLVVDDLLIQCLQQDGI----------------------------------------- ----------------------LTDSMAESIMAKPTSQGRSHQLLFLLPKRGPRAFSTFC SALKETEQHHLCKLLMD-------F-----TEKDKKN---------------SQ------ ---------------------------------------YKLSPEICKKKNKHTH----- ---------TH-------------------------------KSMEM------------- ------------------------------------------------CLD-ADSP---V TTA--VLPCTPEFYQSHRP-QAYPM--RSCPRGLALVLSNVRFD-SANT-------DLDI RRGGEVDEETLRRLFTELDFKVS-LHRDLTAEAMRRCLEQFAQQQE--HAAYDCAVVCLL SHG-VE-------GS-VYGT-------DGQLLELDWVFEVFDNARCPLLQNKPKMFFIQ- -ACRG-------------EEM-DNGV----DQLDGQERTQSPGCE-Q-----RDA----- ------------GREGERDNREKKEEKERERLR-VKLPQRSDMICGFATLK--GT----- --------------------AAMRNTKKGSWFIQELNTAIRQ-------RA--NNTHLSD ILVQVNGQIKSR----EGYA-PGSAHHRCKEMSEF-TSSLCKDLYLFPKYYPSN------ ------- >E_caballus_ENSECAP00000003321 ------------------------------------------------------------ -------------MAAPSAPSLPALQQKGLMAADRGRRILGVCGMHPDHQEALKKNRVVL AKQLLLSELLEHLLEKDI------------------------------------------ ----------------------ITLEMRELIQAKVTSFGQNVELLNLLPKRGPQAFEAFC VALRETKQGHLEDLLLT-------T-----LSG--LQH---------------------- ---------------------------------------VLPPLSCDYDLSLPFP----- ---------VCESC-----------------PPHKQLRLST-DTVEH------------- ------------------------------------------------SLDNGDGP---P CLQ--VKPCTPEFYQAHYQ-LAYRL--QSRPRGLALVLSNVHFT--GEK-------DLEF RSGGDVDHSTLVTLFKLLGYNVH-VLLDQTAKEMQEKLQNFAQLPA--HRVTDSCIVALL SHG-VE-------GG-IYGV-------DGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQ- -ACRG-------------DET-DRGV----DQQDGKNHAKSPECE-E-----SDA----- ------------GKEEL--------------LK-MRLPTRSDMICGYACLK--GT----- --------------------AAMRNTKRGSWYIEALTQVFSE-------RA--CDMHVAD MLVKVNALIKER----EGYA-PGTEFHRCKEMSEY-CSTLCRHLYLFPGHPPT------- ------- >P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MENTENSV-------D-----SKS--------------IKNLE-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PKIIH---G SQSMDS--------GISLD-NSYKM--DYPEMGLCIIINNKNFH--KST-------GMTS RSGTDVDAANLRETFRNLKYEVR-NKNDLTREEIVELMRDV-SKED--HSKRSSFVCVLL SHG-EE-------GI-IFGT-------NG-PVDLKKITNFFRGDRCRSLTGKPKLFIIQ- -ACRG-------------TEL-DCGI-----ETD-S-----GV----------------- -------------DDDM--------------AC-HKIPVEADFLYAYSTAP--GY----- --------------------YSWRNSKDGSWFIQSLCAMLKQ-------YA--DKLEFMH ILTRVNRKVATE---FESFS-FDATFHAKKQIPCI-VSMLTKELYF-YH----------- ------- >H_sapiens_ENSP00000311032 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MENTENSV-------D-----SKS--------------IKNLE-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PKIIH---G SESMDS--------GISLD-NSYKM--DYPEMGLCIIINNKNFH--KST-------GMTS RSGTDVDAANLRETFRNLKYEVR-NKNDLTREEIVELMRDV-SKED--HSKRSSFVCVLL SHG-EE-------GI-IFGT-------NG-PVDLKKITNFFRGDRCRSLTGKPKLFIIQ- -ACRG-------------TEL-DCGI-----ETD-S-----GV----------------- -------------DDDM--------------AC-HKIPVEADFLYAYSTAP--GY----- --------------------YSWRNSKDGSWFIQSLCAMLKQ-------YA--DKLEFMH ILTRVNRKVATE---FESFS-FDATFHAKKQIPCI-VSMLTKELYF-YH----------- ------- >M_domestica_ENSMODP00000005560 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MEDTGTTV-------D-----AKS--------------IKNSG-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------VKSLH---S SKSVES--------GLS-S-DSYKM--DYPEMGLCVIINNTHFH--NDT-------ELSP RTGSDKDAANLIDIFRSLKYEVR-NKNNLTRDKMIELLRQV-SEED--HSQRSSFVCVIL SHG-EE-------GV-IFGT-------DD-SVELKELTYFFKGYKCKSLTGKPKLFIIQ- -ACQG-------------REF-DCGV-----ETD-S-----GT----------------- -------------DEDV--------------AC-HKIPVEADFLYAYSTVP--GY----- --------------------YSLRDPKDGSWFIQALCAVLKQ-------HA--HKLEIMQ ILTRVNRKVATE---FESYS-SKASLHAKKQMPCI-MSMLTKELYF-SH----------- ------- >P_pygmaeus_ENSPPYP00000020323 ------------------------------------------------------------ -------------MAAPTAGSWSTFEHKELMAADRGRRILGVCGMHPHHQETLKKNRVVL AKQLLLSELLEHLLEKDI------------------------------------------ ----------------------ITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFC EALRETKQGHLEDMLLT-------T-----LSG--LQH---------------------- ---------------------------------------VLPPLSCDYDLSLPFP----- ---------VCESC-----------------PLYKKLRLST-DTVEH------------- ------------------------------------------------SLDNKDGP---V CLQ--VKPCTPEFYQTHFQ-LAYRL--QSRPRGLALVLSNVHFT--GEK-------ELEF RSGGDVDHSTLVTLFKLLDYDVH-VLCDQTAQEMQEKLQNFAQLPA--HRVTDSCIVALL SHG-VE-------GA-IYGV-------DGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQ- -ACRG-------------DET-DRGV----DQQDGKNHAGSPGCE-E-----SDA----- ------------GKEKL--------------PK-MRLPTRSDMICGYACLK--GT----- --------------------AAMRNTKRGSWYIEALAQVFSE-------RA--CDMHVAD MLVKVNALIKDR----EGYA-PGTEFHRCKEMSEY-CSTLCRHLYLFPGHPPT------- ------- >H_sapiens_ENSP00000312664 ------------------------------------------------------------ -------------MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVL AKQLLLSELLEHLLEKDI------------------------------------------ ----------------------ITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFC EALRETKQGHLEDMLLT-------T-----LSG--LQH---------------------- ---------------------------------------VLPPLSCDYDLSLPFP----- ---------VCESC-----------------PLYKKLRLST-DTVEH------------- ------------------------------------------------SLDNKDGP---V CLQ--VKPCTPEFYQTHFQ-LAYRL--QSRPRGLALVLSNVHFT--GEK-------ELEF RSGGDVDHSTLVTLFKLLGYDVH-VLCDQTAQEMQEKLQNFAQLPA--HRVTDSCIVALL SHG-VE-------GA-IYGV-------DGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQ- -ACRG-------------DET-DRGV----DQQDGKNHAGSPGCE-E-----SDA----- ------------GKEKL--------------PK-MRLPTRSDMICGYACLK--GT----- --------------------AAMRNTKRGSWYIEALAQVFSE-------RA--CDMHVAD MLVKVNALIKDR----EGYA-PGTEFHRCKEMSEY-CSTLCRHLYLFPGHPPT------- ------- >P_troglodytes_ENSPTRP00000033921 ------------------------------------------------------------ -------------MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVL AKQLLLSELLEHLLEKDI------------------------------------------ ----------------------ITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFC EALRETKQGHLEDMLLT-------T-----LSG--LQH---------------------- ---------------------------------------VLPPLSCDYDLSLPFP----- ---------VCESC-----------------PLYKKLRLST-DTVEH------------- ------------------------------------------------SLDNKDGP---V CLQ--VKPCTPEFYQTHFQ-LAYRL--QSRPRGLALVLSNVHFT--GEK-------ELEF RSGGDVDHSTLVTLFKLLGYDVH-VLCDQTAQEMQEKLQNFAQLPA--HRVTDSCIVALL SHG-VE-------GA-IYGV-------DGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQ- -ACRG-------------DET-DRGV----DQQDGKNHAGSPGCE-E-----SDA----- ------------GKEKL--------------PK-MRLPTRSDMICGYACLK--GT----- --------------------AAMRNTKRGSWYIEALAQVFSE-------RA--CDMHVAD MLVKVNALIKDR----EGYA-PGTEFHRCKEMSEY-CSTLCRHLYLFPGHPPT------- ------- >D_rerio_ENSDARP00000006831 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------MNGDCV-------D-----AKR------------VDTTDASKD------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GASAS---Q PMQVDA-------KPQSHA-FRYSL--NYPNIGHCIIINNKNFD--RRT-------GMNP RNGTDVDAGNVMNVFRKLGYIVK-VYNDQTVAQIMQVLTTV-AHDD--HSRCASLVCVLL SHG-DE-------GV-FFGT-------DT-SVDLKSLTSLFRGDRCPSLVGKPKLFFIQ- -ACRG-------------TEL-DPGV-----ETD-H-----PDHP--------------- -------------DIPD--------------GR-VRIPVEADFLYAYSTVP--GY----- --------------------YSWRNTMTGSWFIQSLCEMMTK-------YG--SELELLQ IMTRVNHKVALD---FESTS-NMPGFDAKKQIPCI-VSMLTKEMYFTP------------ ------- >R_norvegicus_ENSRNOP00000022693 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MTDDQ DCAAELEMADSSTEDGV-------D-----AKPDRSTII--SSLLW-KKKKNAS------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------M-------- CPVSTT-------RDRVPT-YLYRM--DFEKMGKCIIINNKNFD--KAT-------GMDV RNGTDKDAEALFKCFRSLGFEVT-VYNDCSCAKMQDLLRRA-SEED--HSNSACFACVLL SHG-EE-------NL-IYGK-------DG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ- -ACRG-------------TEL-DDGI-----QAD-S-----GPIN-D------------- -------------TDAN--------------PR-YKIPVEADFLFAYSTVP--GY----- --------------------YSWRNPGKGSWFVQALCSILNE-------HG--KDLEIMQ ILTRVNDRVARH---FESQS-DDPRFNEKKQIPCM-VSMLTKELYFGR------------ ------- >M_musculus_ENSMUSP00000026062 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MTDDQ DCAAELEKVDSSSEDGV-------D-----AKPDRSSII--SSILL-KKKRNAS------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------A-------- GPVRTG-------RDRVPT-YLYRM--DFQKMGKCIIINNKNFD--KAT-------GMDV RNGTDKDAGALFKCFQNLGFEVT-VHNDCSCAKMQDLLRKA-SEED--HSNSACFACVLL SHG-EE-------DL-IYGK-------DG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ- -ACRG-------------TEL-DDGI-----QAD-S-----GPIN-D------------- -------------IDAN--------------PR-NKIPVEADFLFAYSTVP--GY----- --------------------YSWRNPGKGSWFVQALCSILNE-------HG--KDLEIMQ ILTRVNDRVARH---FESQS-DDPRFNEKKQIPCM-VSMLTKELYFSR------------ ------- >M_domestica_ENSMODP00000036247 -----------------------------------------------------------M DFHTFLYGIAEEIDSADLASLKFLCLDQIPLKKQQHIKDALVLFQTLEERGLLEEDNLFF LKELLFRINRIDLLNEPLNTKGPEMERELQVPNKARISPYRLHLHTTIWPFRDNWTCRIT LSVSFTS-----RTKQLLSVMVILLFNLSEGVGPSELKSIKFMLSSKIPKCKIEDDMTLM DLFIEMEKRGILGEGNL-------D-----ALKIVCDQ---IDKSLLKKIQEYE------ ------------------------------------------------------ISKG-- ------RNNLFLIYQNT--QPQEVY----------------------------------- ---------------------------------------------------DSAG----- ----------------EKG-NVYKM--SSRPRGYCLIINNFDFK--ISRKERPENHYLTD RRGTNKDEEALKNIFKELHFDIQ-SFQDLTAEGIQQVLKTF-KDNN--HESKDCFVCCLL SHG-NK-------GT-IYGI-------DGKEVPIRDLTSYFSGSNCPSLAGKPKVFFIQ- -ACQG-------------KAT-QYGI---SLDTD-S-----EQQR-ES----LEA----- ------------D-KSF--------------QS-ECIPNEADFLLGMATVE--NY----- --------------------VSYRDSARGTWYIQSLCKNLKE-------GCL-RGNDILT ILTEVNSEVSQK--------TD--PKNNGKQMPQP-KITLRKKLVF-PI---S------- ------- >E_caballus_ENSECAP00000019797 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MENSKISV-------D-----SKS--------------IKNSE-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TKILH---G SKSMDS--------GISLD-SSYKM--DYPEMGLCIIINNKNFH--KST-------GMAS RSGTDVDAANLRETFTNLKYEVR-NKNDLTGEEIVALMRSV-SKED--HSKRSSFICVLL SHG-EE-------GI-IFGT-------NG-PIDLKKLTCFFKGDCCRSLAGKPKLFIIQ- -ACRG-------------TEL-DSGI-----ETD-S-----GI----------------- -------------EDDM--------------AC-QKIPVEADFLYAYSTAP--GY----- --------------------YSWRNSKDGSWFIQSLCAMLKL-------YA--HKLELMH ILTRVNRKVAME---FESYC-LDPTFHGKKQIPCI-VSMLTKELYF-YH----------- ------- >G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MSP RNGTDVDAADAFRTFSKLGYKVT-VANDQTVDQMIQLLVKV-SKQD--HSNSASFVCVLL SHG-DE-------GV-IYGT-------DG-FEKLDDLTKFFKGDRCRSLVGKPKLFFIQ- -ACRG-------------TEL-DEGS-----QIE-A-----DS----------------- -------------VGGQ--------------TS-DRIPVEADFLYAYSTAP--GY----- --------------------YAWRNTQNGSWFMQSLCEMLRR-------FS--GQLELMQ IMTRLNHRVALH---FESSS-DTPGYSGKKQIPCI-VSMLTKDFYF-PK----------- ------- >C_intestinalis_ENSCINP00000007986 ------------------------------------------------------------ --------------------------------------------MLSTHKEKLRTNRHTL CKELVVDELLQELIGEG-I----------------------------------------- ----------------------FNDILADRVLSHQRDFKKNVEFLTLLPGRGPNAFNAFR IALINSDQSHLAELLDP-------A-----QGVSQPNES--NANDGSGGPELSA------ ---------------------------------------SIFRFESIATANSNLPGTSGT SAPLSRRRPMENTDQSSTSIASSQVIYANQGTPPKRNRESS-SYIEQMDDAPSPTDSLSN IRSTASVHSLFSRSDVRTQSNTAINHINTVQSPTSTKAATSYQINLHQGMDLFDGP---T VSDLTVRKSTHQHLMQHTDCYQMTM--RGRPKGAALIISVEKFH--PES-------DLLN REGSEKDRVRLELVLQQIGFQCY-VLINGTAEQIVSTLQTFAELEE--HYDNSCSLVAAM SHG-DA-------GC-FYGS-------DGVSVAIDTVVNFFSNQNCHSLQKKPKIFLFQ- -ACQG-------------DEY-DMGV----DEVDGPVQAPVGDVD-NT----STS----- ------------SSNDH--------------IR-NKLPQKSDMLIGQATMK--GF----- --------------------AAMRNTKHGSWYIQAFVRVLAR-------HA--CDTDLLD MMTKVNNILKHK----EGWC-PGSVYHRCKVMPEF-KSSLSKKLYFFPGI---------- ------- >B_taurus_ENSBTAP00000008706 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------S-KKKKNDS------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------G-------- KSVNIP-------RDRVPT-YQYNM--NFEKVGKCIIINNKNFD--RIT-------GMGV RNGTDKDAEALFKCFRSLGFDVS-VYNDCSCAKMQDLLKKA-SEED--HRNSACFACILL SHG-EE-------NL-IYGT-------DG-KTAIKDLTAHFRGDRCKTLLEKPKLFFIQ- -ACRG-------------TEL-DDGI-----QAD-S-----GPIN-D------------- -------------TDAN--------------PR-YKIPVEADFLFAYSTVP--GY----- --------------------YSWRNPGSGSWFVQALCSILNE-------HG--KSLEILQ ILTRVNDRVARH---FESQS-DDPRFHEKKQIPCV-VSMLTKELYF-------------- ------- >C_familiaris_ENSCAFP00000032189 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MGEQRNTSSKELAAAEATG QSGKELEVSMENTENSV-------D-----AKS--------------FKNAE-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TVIV----- -KILKD--------KYLTK-LHYKM--DYPEMGLCIIINNKNFH--KST-------GMAP RSGTDVDAANLRETFTNLKYEVR-NKNDLTCEEILELMNSV-SKED--HSKRSSFVCVLL SHG-DE-------GI-IFGT-------NG-PVDLRKVTGFFRGDYCRSLTGKPKLFIIQ- -ACRG-------------TEL-DCGI-----ETD-S-----GI----------------- -------------EDDM--------------AC-QKIPVEADFLYAYSTAP--GY----- --------------------YSWRNSKDGSWFIQSLCAMLKL-------YA--HKLEFMH ILTRVNRKVATE---FESFS-LDSAFHGKKQIPCI-VSMLTKELYL-YH----------- ------- >D_rerio_ENSDARP00000072390 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------AFEPYK---KHKNIGKCLIISNEHFP--VQF-------SLNR KKGNSVDERRLSSTFKSLGFHVK-VENNLSANQMIDALRTV-SEED--HTDNSCFVCVLM SHG-EE-------GT-ILGS-------DERWIPVKTLTSLLTSDLCPSLRDKPKIFFLQ- -ACRG-------------VEY-DPGV-----EAD-S-----VEAS--------------- -------------EDFF--------------GI-SDVP-ELDFLCCYSTVE--GY----- --------------------FAWRNPETGSIFIRELCKTLMD-----------CRLEIIQ ILTRVNHLVAYY---FQSYT-LELETNRKRQMPCF-ASRLTKDFYLHV------------ ------- >B_taurus_ENSBTAP00000038128 -----------------------------------------------------------M ALTQCLYNIGEQLGSDDLAALKFLSRDHIPYRKQEPIKDALMLFQRLQEKRMLEENNLSF LKELLFRVNRLDLLLNYLYTSEEEMKRELQIPGRAQISAY-------------------- ------------R---------ILLFQISEDVNKVELKDFKFFLSQEIAKCKLDDDMTLL DIFVEMEKRTILGEENL-------D-----TLKRICEQ---VNKSLLKKIYDYEELR--- -----------------------------------------KERRMSLERDPYAFSNDMS QSLPE-EGYSKMPAMSD--SP-EQD----------------------------------- ---------------------------------------------------SELQ----- ----------------TSD-TVYRM--TSKPRGYCLIFNNYDFS--IARKQVPELHDLKD RTGTDFDADALDKTFRELHFEIV-HYKDLTAKGICEVLESY-QKKD--HKNKDCFICCIL THG-NK-------GI-IYGS-------DGQEASIYELTSYFTGLKCPSLIGKPKIFFIQ- -ACQG-------------DKY-QKGV---AVETD-S-----EQME-AY----LEV----- ------------D-SSP--------------QK-RYIPDEADFLLGMATVK--NY----- --------------------VSYRNIWNGAWYIQSLCQNLRE-------RCP-RGEDILT ILTKVNFEVSKL--------DD--KQRMAKQMPQP-TFTLRKKLFF-PL---N------- ------- >G_aculeatus_ENSGACP00000016983 ------------------------------------------------------------ --------------------------------------------MSARGKVRSQKTAIHE ALCADYSLILNKVFEKGLIT---------------------------------------- ----------------------PREYRNLKSINKESVEGHVIELVDKLLDKGEDTCEAFL SLLQTDDDIVKTYPALRTLQLDDRG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------TLHAPVQ---D TSVGHSDVRPPPSKKLKKD-ERYEL--NSQPSGLCVIINNKNFS--------------KP RRGSDKDAESLGEVFTWLGFRAL-MCKDQTKDQMERALNKF-TALQEAPRHGDALICCIL SHG-RK-------GV-VLGI-------DDQPLSIKQIIGTFLPPANTTLTGKPKVFLIQ- -ACQG-------------GQA-QHGV---FEEL--------------------------- ------------QADDS--------------PS-PTIPKEADVLVAVATVE--DY----- --------------------LAFRHITDGSWFIQSVCEQLKD-------GCP-RGEDITT ILQRVNWEVGKK--------EGCSAPGAGKQMPEV-RFTLRKKLVLSPHPNCFVAK---- ------- >G_gallus_ENSGALP00000013506 -----------------------------------------LKSFKPHWISSNMEDDDSL QFRQLLLLIDEGLGAEDVAALKFLCTDLIPFRKLESVQSAMDIFQLLIDEDYLNEEDTFL LAELLYRIKYHSLL-SKLGYTKEKVQECL--HEKGKVSPYR------------------- ----------------------QMLYELSENITNDMLQEIVFLLRNHLPKRR--RTISAL ELLILLEKQCLLTENNV-------Q-----ILEEVFRN---VSPDLLETVKCYRMAK--- ----------------VALPHQGNTLPIKESSPSYTVHVRLFNSPQGGSFILVLNESYCE SLRNKKYSVTGASAACHAISMPSTG----------------------------------- ------------------------------------------------------------ -VQNALANTTVCYSSFLQV-SSYKM--DGPRRGICLVINNVKFD-----------GVLQE RKGSYKDACELERVFTWLGLDVR-TYTDQTSDQIKELMQAWQRSED--HKNRDCFVCCIL SHG-ES-------GA-VYGK-------DGKLVSIRTIMTYFTAKQCPQLTEKPKLFFVQ- -ACQG-------------KEV-QRPV---YVETD-A-----RVPDFSSV----------- ------------PQSTS--------------PS-ESIPEEADFLLGMATID--GY----- --------------------ASFRHVQEGTWYIQALCSKLQL-------LVPSRGEDILS ILTEVNEDVSKR--------VD--RYGTRKQMPQP-AYTLRRKLIF-PIPRDPPPS---- ------- >A_gambiae_AGAP000830-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------MSMPDVVDIRNEINKEHVRESLDRNGDEQ QLVQDVNDALGTRKGHD------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------P TNHLVRARM----PVERYA-CDYNM--NHKRRGLALIFNHENFD--VP--------QLRS RAGTNVDCENLTASLKGLDFEVH-VFKDLKLRDLQKEVERV-SQMD--HSDADCLLVTIL SHG-EL-------GY-LYAK-------DC-QYKLDTIWTYFTANHCPSLAGKPKLFFIQ- -ACQG-------------DQL-DGGV-----VLE-A-----KDRTETD------------ ------------SSSSM--------------LT-FKIPMYADFMIAYSTIP--GF----- --------------------YSWRNTQKGSWFIQSLCHELNQ-------NG--RKYDLMV LLTFVTQRVAYD---FESNTPDIPMMHQQKQIPCT-TSMLTRLVYFNQKK---------- ------- >T_guttata_ENSTGUP00000010625 ------------------------------------------------------------ DFRKLLFEVSEALVTEELSALKFLSLDHVPRRKLEAIHEPKAFFEVLQEKDMIGAGNLFF LKELLYRIHRIDLLSTPLGCSREEMERELQLPGRAQVSAY-------------------- ------------R---------QLLYGIAEDLTSEDVRSVKFLLQKQLPKNKLQENASML QVFLEMEIKGIIKEDNM-------T-----TLKDILQR---FRADIKKKIDAYEEKK--- -----------------------------------------KGLTGSAEVSLELPVSWI- -------DSVDHIKQSTLGLPGEDR----------------------------------- ---------------------------------------------------SLSF----- ----------------QLL-EAYKM--TSRPCGVCLILNNHNFA--KAREGVLEHKHMKD RNGTDVDAAALRNVFSKLHFRVE-EYRDLTAEEIRETVNIF-QSAD--HEDKDCFVCCIL SHG-KK-------GI-IYGV-------DGQEVPIRELTTSFTAQNCSSLAGKPKVFFIQ- -ACQG-------------DAF-HKGV---AIETD-S-----VEED-SS----LER----- ------------D-ARF--------------QL-DCIPAEADFLLGMATLQ--DY----- --------------------VSYRSPKEGTWYIQALCQHLEY-------SCP-RGEDVLT ILTAVNQEVSKK--------TC--ERDAKKQMPQP-SFTLRKRLIF-PV---N------- ------- >G_aculeatus_ENSGACP00000013740 ------------------------------------------------------------ ------------------------------------------CGMQERDRLALRTRSTVL CKQLVVDELLIQSLQTDEI----------------------------------------- ----------------------LTEAMAENIMAEQTSQKRSWRLLLLLPKRGPRAFSSFC SALQETEQQHLYELLIQ-------S-----SEKDGKETP--------------------- ---------------------------------------GMLMCGQFIDSSLPLP----- ---------TQEVV------------------AAKRARTQA-ESMEF------------- ------------------------------------------------SLD-ADSP---I NSP--VLPCTPDFYLSHCH-QSYRM--NSSPRGFALVISNVTFDPCAAP-------DLDP RKGGEVDDEVLRKVFTELDYVVK-VHRDLTAQDMRTCIEEFSRRPD--HRTMASCVVCLL SHG-VE-------GA-IYGT-------DGQLLKLDWVFESFDNAHCPLLQNKPKMFFIQ- -ACRG-------------EEM-DCGV----EQIDGPVRTCSPSCE-Q-----RDA----- ------------GREGQGD-ASARQRGDM--GR-IKLPQRSDMICGFASLK--GT----- --------------------AAMRNTKRGSWFVQELNKRLRL-------HA--RDTHLAD IMVQVNRHIKER----EGYA-PGTAHHRCKEMSEF-TSSLCKDLYLFPKYQPQ------- ------- >M_mulatta_ENSMMUP00000015808 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MENTENSV-------D-----SKS--------------IKSLE-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PKIIH---G SKSVDS--------GISLE-NSYKM--DYPEMGLCIIINNKNFH--KST-------GMAS RSGTDVDAANLRETFINLKYEVR-NKNDLTREEIVELMRNV-SKED--HSKRSSFVCVLL SHG-EE-------GI-IFGT-------NG-PLDLKKITSFFRGDCCRSLTGKPKLFIIQ- -ACRG-------------TEL-DCGI-----ETD-S-----GV----------------- -------------EDDM--------------AC-HKIPVEADFLYAYSTAP--GY----- --------------------YSWRNSKDGSWFIQSLCAMLKQ-------YA--DKLEFMH ILTRVNRKVATE---FESFS-LDATFHAKKQIPCI-VSMLTKELYF-YH----------- ------- >G_gallus_ENSGALP00000013571 ---------------------------------------------------------MSS DFRKLLFDISEALATEELAALKFLSLEHVPVRKQEDTEEPKAFFEVLKEKGMIEVEDLFF LKELLYRINRIDLLASHLGSSREEMERELQVPGKAKVSAYR------------------- ----------------------QLLYGIAEDLTPDDVRSIKFLLQEKLPKNKLQDNASML KVLVEMERNGIIKEDDL-------T-----MLKSILKA---FRADLKKKIDNYEEKT--- --------------------------------------------KGWPWKSSCFPNKTQA LSISENLAVSSLIDN--------------------------------------------- ---------------------------------------------------KESQE---S QSEWYSAGIFPPHVQILLV-ESYKM--ENNPHGYCVILNNYRFK--NPN---------ET RKGTVEDGKALKRVFKWLQFDTI-EYMDLEAKQIFAKVNEY-SKKD--HSNMDCFVCFIL SHG-EK-------GK-IKGV-------DNELVNIKDLLSCFSGSNCPSLAGKPKLFFIQ- -ACQG-------------SVG-HPAV---TVKED-C-----SGHL--------------- ------------ETDAI--------------PA-LSIPDQADVLVGMATVE--DF----- --------------------ECYRSIETGSVYIQCLCDKMEL-------LCP-LRKDLIT ILTEVNKEVGRR------------VLNGWKQMPKI-TSTLRKQFIF-QIPQCQ------- ------- >G_gallus_ENSGALP00000014503 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------KKKNGE------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------EEQPK---S SLSNQY-------RIVTPT-FQYNM--NYKKVGKCIIINNKNFE--DKT-------GMGT RNGTDKDAGDLSKSFRSLGFDVY-TYNDRSCEDMQTLLKQA-AEEN--HSDAACFACILL SHG-EE-------GL-IYGT-------DG-PMAIKHLTTLFRGDKCKTLIGKPKLFFIQ- -ACRG-------------SEF-DEGI-----QTD-S-----GPAN-DTL----------- ------------ETDAN--------------PR-YKIPVEADFLFAYSTVP--GY----- --------------------YSWRNPGRGSWFVQSLCSVLNE-------HG--KQLEIMQ ILTRVNYVVATN---FESQS-DDPRFSEKKQIPCV-VSMLTKELYF-------------- ------- >A_gambiae_AGAP011951-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------ECYDT--SNARRGIALIINQVIFS------------SMAV RVGSSKDRTDISTVLQRIGFEVR-VMDDPNRKQLLSALKQL-AGED--HSHSDCLVVVVM THGKEN-------NL-LYAS-------DK-SYEANQLWEPFIGDACPSLIGKPKLFFVQ- -ACRG-------------KKL-DEGVIQATISID-S-----VDTQ--------------- ------------SSPGS--------------MR-YVIPAMADLLVMYSTYD--GH----- --------------------YSWRNPSKGSWFIQSLCAELGA-------SA--HCKELLH ILTAVSRRVAYH---YQSNVPDNAKIDAKKQMPCM-VSMLTKLLYLRPKK---------- ------- >P_pygmaeus_ENSPPYP00000003106 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------MDCVGWPPGRRWHLEKNTSCSGSSGICASYVTQMADDQ GCVEEQGLGDSANEDSV-------D-----AKPDRSSFV--PFLFS-MKKKNVS------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------M-------- QSIKTT-------RDRVPT-YQYNM--NFEKLGKCIIINNKNFD--KVT-------GMGV RNGTDKDAEALFKCFRSLGFDVI-VYNDCSCAKMQDLLKKA-SEED--HTNAACFACILL SHG-EE-------NL-IYGK-------DG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ- -ACRG-------------TEL-DDGI-----QAD-S-----GPIN-D------------- -------------TDAN--------------PR-YKIPVEADFLFAYSTVP--GY----- --------------------YSWRSPGRGSWFVQALCSILEE-------HG--KDLEIMQ ILTRVNDRVARH---FESQS-DDPRFHEKKQIPCV-VSMLTKELYFSQ------------ ------- >O_latipes_ENSORLP00000015114 ------------------------------------------------------------ ------------------------------------RSVTQKCGMQKRDAEALRNCSVCL LKDLVVDELLIQALVKDGI----------------------------------------- ----------------------LTQNMAESIMVQKTSHHRSFKLLLLLPKRGPRAFKSFC SALKETEQEHLCDLLTQEEEGREVC-----LDTPLIN----------------------- -----------------------------------------SEEQSEVSSSMSYP----- ---------IHDSE-----------------GLQLEMRTNT-ESMES------------- ------------------------------------------------SLD-ADSP---I NTP--VLACSADFYLSHCQ-QSYRM--NSSPRGSVLVISNINFDPRAAP-------ELDP RKGGEVDDEVLRKLFTELDYSVN-FHRDLTAQDMKMVIENFCRRPD--HQKVDSCVVCLL SHG-VD-------GA-IYGT-------DGQQLALDWVFEAFDNAHCPLLQNKPKMFFIQ- -ACRG-------------DEM-DCGV----EQIDGPARTFSPTCE-Q-----RDA----- ------------GREEQGD-ADGRQRASTGRQR-IKLPQRSDMICGFASLK--GT----- --------------------AAMRNTKKGSWFIQELNTALRL-------NA--RDTHLAD ILVQVNKRIKER----EGYA-PGTAHHRCKEMSEF-TSSLCKDLYLFPKYQPQC------ ------- >C_familiaris_ENSCAFP00000016420 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MADDQ DCGMEQAAGDSESPDAV-------D-----ARPDRSSFV--PSLFS-RKKKNDS------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------G-------- RSIKTA-------QDQVPT-YQYNM--NFEKVGKCIIINNKNFD--KTT-------GMGV RNGTDKDAEALFKCFRNLGFDVV-IYNDCSCAKMQDLLKKA-SEED--HRNSACFACILL SHG-EE-------NL-IYGT-------DG-MTAIKDLTAHFRGDRCRTLLEKPKLFFIQ- -ACRG-------------TEL-DDGV-----QAD-S-----GPIN-D------------- -------------TDAN--------------PR-YKIPVEADFLFAYSTVP--GY----- --------------------YSWRSPGSGSWFVQALCSTLNE-------HG--KSLEILH ILTRVNNRVARH---FESQS-DDPHFHEKKQIPCV-VSMLTKELYF-------------- ------- >P_troglodytes_ENSPTRP00000005216 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------MDCVGWPPGRKWHLEKNTSCGGSSGICASYVTQMADDQ GCIEEQGVEDSANEDSV-------D-----AKPDRSSFV--PSLFS-KKKKNVT------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------M-------- RSIKTT-------RDRVPT-YQYNM--NFEKLGKCIIINNKNFD--KVT-------GMGV RNGTDKDAEALFKCFRSLGFDVI-VYNDCSCAKMQDLLKKA-SEED--HTNAACFACILL SHG-EE-------NV-IYGK-------DG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ- -ACRG-------------TEL-DDGI-----QAD-S-----GPIN-D------------- -------------TDAN--------------PR-YKIPVEADFLFAYSTVP--GY----- --------------------YSWRSPGRGSWFVQALCSILEE-------HG--KDLEIMQ ILTRVNDRVARH---FESQS-DDPRFHEKKQIPCV-VSMLTKELYFSQ------------ ------- >T_nigroviridis_ENSTNIP00000009934 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----MSANGPASGEDFT-------D-----ASK---------------GGEQPS------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GSSSS---G KMTVDA-------KSARYS-FRYSL--DFPNLGHCIIINNKNFD--RRT-------GMNT RNGTDVDAANAMKVFSNLGYRVR-VHNDQTVAQISQLLTSA-AKED--HSRCASFVCILL SHG-DE-------GV-LYGT-------DG-PMEIKSLTSLFRGDRCRSLVGKPKLFFIQ- -ACRG-------------NDL-DGGI-----ETD-S------------------------ -------------IEDN--------------ST-TKIPVEADFLYAFSTAP--GY----- --------------------YSWRNTMSGSWFMQSLCDTISK-------YG--KELELQH ILTRVNHKVAVE---FESDS-SLPGFNAKKQIPCI-VSMLTKEMYFS------------- ------- >G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------DK-YRYKM--DYPCMGTCVIINNKTFD--PKT-------GLSP RNGTDVDAAELEKTFSRLGYKVT-VANDQTADQMVDLLADV-SKQD--HRKSASFVCALL SHG-DE-------DG-IYGT-------DG--TSLDDLTKFFKGDRCRSLVGKPKLFFIQ- -ACRG-------------TDT-DRGV-----NFD-A-----DS----------------- -------------TDGQ--------------ML-QSIPLEADFLYAYSTPS--GY----- --------------------YSWRNTQNGSCFMQSLCEILHS-------FS---QLELMQ IMTRVNYEVALH---FESSS-DKLGYSGKKQIPCI-MSMLTKDFYF-PK----------- ------- >O_latipes_ENSORLP00000010793 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -MDMAETAEELSGKDQV-------D-----TKP--------------VISKRSP------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------ANQP---N PRSTDVCVI----KQDADP-YRYSM--DYPKMGICLIINNKNFH--KDS-------GMGP RNGTDNDAAAAWKSFMKLGYEIQ-MYNDQTVDQMKKLFRQM-SNQD--HSKFASFACVIL SHG-EE-------GV-IYGT-------DG-PVSFNKLIECLKGRSCLSLVGKPKLFFIQ- -ACRG-------------TLF-DEGI-----EHD-A------------------------ --------------KDD--------------TS-EKIPLEADFLFAYSTVS--GY----- --------------------YSWRSTANGSWFIQSLCEMLEK-------FS--KTLDLMQ IMTRVNHKVATH---FESSS-NAPGFSGKKQIPCI-VSMLTKDFYF-PYESN-------- ------- >B_taurus_ENSBTAP00000024166 ------------------------------------------------------------ -------------MAAPSAGFQYPLQPKEQMAADRGRRMLRGCGMHPDHQEALKKNRVVL AKELLLSELLEHLLEKDI------------------------------------------ ----------------------ITLEMREHIQAKTGSFGQNVELLNLLPKRGPQAFDAFC VALRETKQSHLEELLLR-------T-----LSG--LQP---------------------- ---------------------------------------VVPPLSCDYDLSLPFP----- ---------VCESC-----------------TRHKRLHLSP-DAVEH------------- ------------------------------------------------SLDHGDGP---P CLQ--VKPCTPEFYQTHHH-LAYRL--QSRPRGLALVLSNVHFT--GEK-------DLEF RSGGDVDHSTLVTLFKLLGYKVH-VLLDQTAQEMQEKLQNFAQLPV--HRVTDSCIVALL SHG-VE-------GG-VYGV-------DGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQ- -ACRG-------------DET-DRGV----DLQDGKNHDRSPKCE-E-----SDA----- ------------SREEL--------------LK-MRLPTRSDMICGYACLR--GT----- --------------------AAMRNTKRGSWYVEALTQVFSE-------RA--CDMHVAD MLVKVNALIKER----EGYA-PGTEFHRCKEMSEY-CSTLCRHLYLFPGHPPT------- ------- >G_gorilla_ENSGGOP00000007184 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MADDQ GCVXXXXXXXXXXXXXX-------X-----XXXXXXXXX--XXXXX-XXXXXXX------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------X-------- XXXXXX-------XXXXXX-XXXXX--XXXXXXXXXXXXXXXFD--KVT-------GMGV RNGTDKDAEALFKCFRSLGFDVI-VYNDCSCAKMQDLLKKA-SEED--HTNAACFACILL SHG-EE-------NV-IYGK-------DG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ- -ACRG-------------TEL-DDGI-----QAD-S-----GPIN-D------------- -------------TDAN--------------PR-YKIPVEADFLFAYSTVP--GY----- --------------------YSWRSPGRGSWFVQALCSILEE-------HG--KDLEIMQ ILTRVNDRVARH---FESQS-DDPRFHEKKQIPCV-VSMLTKELYFSQ------------ ------- >T_rubripes_ENSTRUP00000045375 ------------------------------------------------------------ --------------------------------------------MEERHKKILQRNRTNL VGELDPSSLYDGLIEKRVFT---------------------------------------- ----------------------HDMIDEIKS--SGTRRDQARQLIRDLETRGSRAFPLFL ECLQETGHHTLVELLQD-------G-----GPAVQIQP-PTPVPIDRPVIQPLP------ ---------------------------------------VCKSAIRSRVLRGTMTVKAAP PVDVVRRDKAPVIPVPQPST---------------------------------------- ------------------------------------------------APSPSPER---E YMRLKPQGR----IRRDSI-QSYKM--DANPSGHCLIINNVDFE--PRS-------ELND RKGSNTDCDRLESRFKALNFIVK-VKTNLKQRQIKHELSAL-SKMD--HSQYDCCVVVLL SHG-TEVSHSRFPGA-VYGV-------DGQFVPVQHITTYLNGQHCPSLQGKPKLFFIQ- -ACGG-------------DEK-DTGF---EVSPDEF-----EPPV-VS----AHDQTDAI PMSSSSDSLSM-SDEPD--------------AR-ASLPTPSDILVSYSTFP--GY----- --------------------VSWRDTQSGSWYIETLDRILEE-------NA--ATDDLVT MLMMVNHEVSQN-----------QAKGLYKQMPGS-FNFLRKLLYFQS------------ ------- >G_gallus_ENSGALP00000013591 -----------------------------------------------------------M EFSQLLFVISEALDRTELASLKFLSLEHVTVRKREDIEEPKAFFQALQEKGMIEVGDLFF LKELLYRINRIDLLASYLGSSREEMERELQVPGRARVSPF-------------------- ------------R---------YLLFQLSENITKDDMKCFKFLLGKELPKCKLSPETTMP DVFIEMEKKGILKEDNL-------T-----VLKTICGK---VDKSLLKKIEDYE------ -------------------------------------------LNLLGEGEMLVTEGQRS STGAPEDSAIWLASSVAPDSLGNCD----------------------------------- ------------------------------------------------------------ --------------QSSQL-EVYKM--TSRPRGVCLILNNHNFA--KAREAVPELRRMKD RNGTHVDADALRKVFSNLHFTVA-EYKDCTAEEIRNIVNNY-RCMD--HNNKDCFVCCIL SHG-KK-------GI-IYGV-------DGQEVPIQELTTSFTGQNCQSLAGKPKVFFVQ- -ACQG-------------DAY-QKGV---TIETD-S-----GEQD-YS----LET----- ------------D-ARF--------------QL-DCIPSEADFLLGMATLQ--DY----- --------------------VSYRSPSQGTWYIQSLCQHLES-------SCP-RGEDILT ILTAVNQEVSSK--------ID--KQNAGKQMPQP-SFTLRKKLIF-PV---N------- ------- >T_nigroviridis_ENSTNIP00000013855 ------------------------------------------------------------ --------------------------------------------MEERHKKILQRNRINL VSELEPLNLYDGLIEKGVFT---------------------------------------- ----------------------HDMIDEIKC--SGARRDQARQLVRDLETRGSRAFPAFL ECLKETGYHSLAELLQN-------G-----APTVQIQP-PTPIPVDRPVIQPLP------ --------------------------------------------ISPPLVPPE------- ---------EPVSPVPKPST---------------------------------------- ------------------------------------------------PGRASPEV---E YVTL--KGR----IRRDSL-QSYRM--EANPLGHCLIINNVEFE--PKS-------GLSN RNGSNVDCDRLERRFKALNFTVK-VKTNLKQRQIRQELSAL-SKVD--HSQYDCCVVVIL SHG-TEVSHSRFPGA-VYGV-------DGQFVPVQHIATYLNGQYCPSLQGKPKLFFIQ- -ACGG-------------DEK-DTGF---QVSPDEF-----EPPV-VG----ADDQTDAI PVSSSSDSLSM-SDEPD--------------AR-ASLPTSSDILVSYSTFP--GY----- --------------------VSWRDPKAGSWYVETLDRVLEE-------NA--ALHDLVV MLTMVNDEVSQN-----------QAKGLYKQMPGS-FNFLRKRLYFIAQP---------- ------- >A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------IP---V SKSVDS--------VIEAD-ESYRM--DHPEMGLCILVNNKNFH--PAT-------GMSY RSGTDRDAAHVVDTFRTLGYMVK-PYNDLTCKQIVDVLHNV-SKDD--HHKRNSFVCVLL SHG-ED-------GL-IYGT-------DG-HVELKMLTSFFRGDKCKSLAGKPKLFFIQ- -ACRG-------------TEL-DSGI-----ETD-S-----AS----------------- --------------DES--------------MC-QKIPVEADYLYAYSTAP--GY----- --------------------YSWRNSSDGSWFIQSLCSMLKQ-------YS--HKLELMQ ILTRVNRKVT-E---FTSCS-NHPDFHGKKQIPCI-MSMLTKDFYF-PH----------- ------- >A_aegypti_AAEL003444-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M DTTDELDVLGFGSRTNE------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S SKSIKEALV----SRAALD-EYYDT--TNKRRGIALVFCHMNFS------------VMAK RNGADKDRDDICNTLYGLDFDVR-VFDDLSRKEVLDRLKDV-SRED--HSDNDCLVVVMM SHG-EQ-------GV-LYAR-------DN-KYNVDSLWKNFVGNACPSLIGKPKMFFIQ- -ACRG-------------EQF-DEGVAYAAKSPKDM-----VD----------------- ------------SRQEQ--------------VL-YSIPAMADLLVMYSTYD--GY----- --------------------YSWRNPRQGSWFIQSLCTELDE-------NG--RVRDLLT LLTGVSRRTAYE---FQSFVPHNAKMDAMKQIPCI-VSMLTKTFYFTKKTRSRVVTDID- ------- >O_cuniculus_ENSOCUP00000009498 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MADDQ AHAGELGAGDSESADAV-------D-----AKPDRSSFV--PALFS-KKKKNGP------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------K-------- QSAKAT-------RDQVPS-YQYNM--NFDKMGKCIIINNKNFD--KVT-------GMGV RNGTDKDAEALFKCFRSLGFDVM-VYNDCSCARMQDLLKRA-SEED--HTNSACFACILL SHG-EE-------NL-IYGK-------DG-VIPIKDLTAHFRGDRCKTLLEKPKLFFIQ- -ACRG-------------TEL-DDGI-----QAD-S-----GPIN-D------------- -------------TDAN--------------PR-HKIPVEADFLFAYSTVP--GY----- --------------------YSWKNPGRGSWFVQALCSILDE-------HG--KELEVMQ ILTRVNDRVARH---FESQS-DDPRFNEKKQIPCV-VSMLTKELYFCR------------ ------- >T_guttata_ENSTGUP00000011206 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------KKKNGE------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------EEQPK---P SLSNQY-------RIVTPT-FQYNM--DYKKVGKCIIINNKNFE--DKT-------GMGT RNGTDKDAGDLAKSFKNLGFEVD-IHHDRSRDDMEKLLKKA-AEEN--HSDAACFACILL SHG-EE-------GL-IYGT-------DG-PMAIKSLTALFRGDKCKSLIGKPKLFFIQ- -ACRG-------------SEF-DEGI-----QTD-S-----GPAN-DTL----------- ------------ETDAN--------------PR-YKIPVEADFLFAYSTVP--GY----- --------------------YSWRNPGRGSWFVQSLCSVLNE-------HG--KQLEIMQ ILTRVNYVVATN---FESQS-DDPRFSEKKQIPCV-VSMLTKELYF-------------- ------- >A_gambiae_AGAP004921-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSCNLMDDLPPEPTPDNEFYD GNIPSITQTD-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------Q IASRQRSQN----ARALQE-EEYDT--NHRRRGMAIILNHENFE------------LMSK REGTNRDRDAATAVLTSMQFDVR-VYNDLGRDELFCVLLAL-ASED--HSDCDCLLVMLM THG-DD-------DV-LYAY-------DG-PYSVDKLWESFMGNACTTLLGKPKLFFVQ- -ACRG-------------STF-DKGVKLGCRDLD-S------------------------ ------------DHFSS--------------HK-YVIPTTADLLVMYSSYK--GH----- --------------------VSWRSPRGGSWFIQALCVELET-------NW--KHMELLQ LLTGVSRRVAYD---YQSNEPSKGRMDAMKQMPSI-VSMLTKLVYF-PLKLGS------- ------- >H_sapiens_ENSP00000358327 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------MDCVGWPPGRKWHLEKNTSCGGSSGICASYVTQMADDQ GCIEEQGVEDSANEDSV-------D-----AKPDRSSFV--PSLFS-KKKKNVT------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------M-------- RSIKTT-------RDRVPT-YQYNM--NFEKLGKCIIINNKNFD--KVT-------GMGV RNGTDKDAEALFKCFRSLGFDVI-VYNDCSCAKMQDLLKKA-SEED--HTNAACFACILL SHG-EE-------NV-IYGK-------DG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ- -ACRG-------------TEL-DDGI-----QAD-S-----GPIN-D------------- -------------TDAN--------------PR-YKIPVEADFLFAYSTVP--GY----- --------------------YSWRSPGRGSWFVQALCSILEE-------HG--KDLEIMQ ILTRVNDRVARH---FESQS-DDPHFHEKKQIPCV-VSMLTKELYFSQ------------ ------- >A_carolinensis_ENSACAP00000001629 ------------------------------------------------------------ -FRQILLAIDENLGKEDVDAMKFLCSDFISTKHLEGVETAQDIFQLLINRNLLSKEDTFI VAELLYRIKCHFLL-QKIGYTQQKVEHNL--FHIRNVSEYR------------------- ----------------------QMLYEISEGFTEENVKTAMFLLREHLPKKQ----SIAV KLLTSLEKQDLLAEDKL-------A-----ILEKICNK---VSPELRNKVDKFKERS--- ---------------------------VFKAFVFSLCYENLYPSNFLAVFLLILQAS--- ------------------------------------------------------------ ------------------------------------------------------------ --------------------TCYKM--DGLNRGSCLIFNNVHFE-----------GGLSQ RRGSQKDAEELESVFRWLGLDVI-KYNDTTSIEMENHLKQWQSFEN--WKDMDCLVCCIL SHG-ES-------GK-IYGT-------DGNLIPIRTIMSYFTAKQCPQLAKKPKLFFIQ- -ACQG-------------EKT-QQPV---YLETD-D-----EYGS--------------- ------------FPLQQ--------------MI-SSIPEEADFLLGMATVD--GY----- --------------------LSFRHVHQGTWYIQALCDKLRT-------LVP-RGEDILS ILTEVNADVSRR--------AD--AQGQKKQMPQP-AYTLRKKLIF-PIP---------- ------- >D_rerio_ENSDARP00000063081 ------------------------------------------------------------ -------------------------------------------MSKKESTQRILQHKVFL IDTLSVEASFILQNVQQAKL---------------------------------------- ----------------------ITQRDYNNLSDVSERETKIIKLLDKLIGRGEETCQEFI DLLRQDCV---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------L ENFPVLEGHAIFASSVQKV-SQYKI--TQNPRGICVIINNVDFT------------SMGE RRGSDEDQNYLAKVFRWLGFEVV-AHRNKTAAEMKNILQAL-GRTV----DGDCFVCCVL SHG-VE-------EG-VCGT-------DGSLVSVDEIRNPFTGVNCQKLVGKPKLFFIQ- -ACRG-------------QRK-QLRV---NAQADGPGDGESEME---------------- ------------VDGDD--------------FD-ITIPSDTDFLIARSTTD--GH----- --------------------VSYRKPDEGSWFIQSLCRNLEK-------HCP-LGADILT ILLSVNNEVSIQ-------------GLHSKQMPVH-EVAMRMKLILPPVNN--------- ------- >X_tropicalis_ENSXETP00000008971 -----------------------------------------------------------M DFNSMLLSIDDGLGREDIEALKFLCRDVLRKNKLLSVRSGQELFQQLMTEDLINEDNFFL LKELLYIINHHSLL-RNLGTNKEKVQKAL--PRQGRISPYR------------------- ----------------------QMLYQLSENIAGDDEKRVYFLLPL---QKKHKENKTFL EVLCQLERENSITEDDV-------E-----LLEDIFKK---VAPDLLKIIEKYKERG--- ------------------DKLHQTENHLIDPSAPPEDEHELINPPLSIQVSSKDSELWDK GTESLIEHTGMIHEEAEKEDDKSGN----------------------------------- ---------------------------------------------------INHQL---S DLRLNSEMT----PQANKE-EFYDM--NHKHRGYCLIIDNSVFM------------KGNR REGSDKDAGALSDVFSWLGLEVD-IFENLMSEQIRDCLKRF-KSRD--HSERDCFVCCIL THG-ES-------GT-VMGS-------DDKEVSIREIMSYFTAISCTSLVLKPKLFFIQ- -ACQG-------------KFT-HPSS---KVEAD-A-----IVPE--------------- -------------ENKK--------------YV-VNVPKDADFLLGMSTVD--GY----- --------------------AAYRHTREGSWYIQALCKNLVE-------LVP-RGEDILA ILTKVNKDVSLK--------EG--QQGILKQMPQP-SYTLLKKLRF-PVPDVPFRPKTCQ ENSP--- >T_guttata_ENSTGUP00000017449 ------------------------------------------------------------ --------------------------------------------MEERQRRALRRGRARL VAALRVEPLWEPLEQRGLFT---------------------------------------- ----------------------RPMLEELQS--AGSRGEQARQLIIDLETRGKQAFPAFL SILRDTGQGHLAEMLMQ-------E-----CESRPVPPQLPDLRPVE------------- ------------------------------------------------------------ ----LELQEANQRCAVVLQTAAR------------------------------------- -------------------------------------------------DVAAGIP---L TVGKSPE------VMSFII-LDYEM--KADPCGHCLILNNVNFC--RDS-------GLST REGSDIDCEKLERRFKALCFTVL-TRRDLKAQEMVLELLKL-SRQD--HSALDCCIVVIL SHG-CQTSHIQFPGG-VYGT-------DGKPIPIEKIVNYFNGSSCPSLRGKPKLFFIQ- -ACGG-------------EQR-DQGF---VVDCDSP-----KEEA-LG----DSLESDAI PFRVPSDN----VDEPD--------------AI-ASLPTPSDILVSYSTFP--GF----- --------------------VSWREKSSGSWYVETLDSVLEQ-------YA--HSEDLLS MLVRVAHAVSAR--------------GRYKQIPGC-FNFLRKKFFFVCR----------- ------- >T_rubripes_ENSTRUP00000037606 ------------------------------------------------------------ ------------------------------------RSKMLHCGMREQDARTLRRQSAVL CKQLVVDELLIQCLQADDI----------------------------------------- ----------------------LTESMAESIMAEQTSQKRSWRLQLLLPKRGPKAFSSFC SALRATDQQHLCDLLTQ-------T-----FETNGNG----------------------- -----------------------------------------THVETCVDSSVPLP----- ---------TQEAV-----------------PGVCVCVCET-ESLEV------------- ------------------------------------------------SLD-ADSP---I NTP--VLPCTPDFYLSHFQ-QSYKM--ASSPRGFALVISNVTFNPCAAP-------ELDP RKGGEVDDEVLRKVFTELEYSVT-VQRDLTAQGIKTCIQNFSGRPE--HRSVDSCVVCLL SHG-VE-------GA-VYGI-------DGELLQLDWVFEAFDNAHCPLLQNKPKMFFIQ- -ACRG-------------DEM-DCGV----EQIDGPSRTSSPSCE-Q-----RDA----- ------------GREGR--------------PR-IKLPQRSDMICGFASLK--GQDS--- --------------------SHAEHQKRGSWFIQELNTALRL-------HA--RDRHLAD ILVQVNRRIKDR----EGYA-PGTAHHRCKEMSEF-TSSLCKDLFLFPKYQPQ------- ------- >E_caballus_ENSECAP00000013731 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MADDQ DCVVEQGAGDSTSTDAV-------D-----AKPDRSSFV--PSLFS-KKKKNGP------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------E-------- RSITTN-------RNREPT-YQYNM--NFEKVGKCVIINNKNFD--RGT-------GMGV RNGTDKDAEALFKCFRNLGFDVV-VYNDCSCAKMKSLLKQA-SEED--HRNSACFACILL SHG-EE-------NL-IYGT-------DG-MTPIKDLTGHFRGDRCKTLLEKPKLFFIQ- -ACRG-------------TEL-DDGI-----QAD-S-----GPINDD------------- -------------TDAN--------------PR-YKVPVEADFLFAYSTVP--GY----- --------------------YSWRNPGSGSWFVQALCSILNE-------HG--KSLEIIQ ILTRVNHRVARH---FESHS-DDPRFHQKKQIPCV-VSMLTKELYF-------------- ------- >C_familiaris_ENSCAFP00000005409 ------------------------------------------------------------ -------------MAAASAGRPAALQRKAPTAAGRGRRILGVCGMHPDHQEALKKNRVVL AKQLLLSELLEHLLEKDI------------------------------------------ ----------------------ITLEMREHIQAKVGGFSQNVELLNLLPKRGPQAFDAFC VALRETKQGHLEDLLLT-------T-----LSG--LQH---------------------- ---------------------------------------GLPPLSCDYDLSLTFP----- ---------MCESC-----------------PPQKQLRLSP-DTVEH------------- ------------------------------------------------SLDNGDGP---P CLQ--VKPCTPEFYQTHYQ-LAYRL--QSRPRGLALVLSNVHFT--GEK-------DLEF RSGGDVDHSTLVTLFKLLGYKVH-VLLDQTAQEMKEKLQNFAQLPA--HRVTDSCIVALL SHG-VE-------GG-IYGV-------DGKLLQLQEVFRLFDNASCPNLQNKPKMFFIQ- -ACRG-------------DET-DRGV----DQQDGKNHTGSSECE-E-----SDA----- ------------SKEEL--------------LK-TRLPTRSDMICGYACLR--GT----- --------------------AAMRNTKRGSWYIEALTQVFSE-------RA--CDTHVAD MLVKVNALIKER----EGYA-PGTEFHRCKEMSEY-CSTLCRHLYLFPGHPPT------- ------- >D_rerio_ENSDARP00000034228 ------------------------------------------------------------ --------------------------------------------MAKSIKDHLQDALSNI GADNLRRFQSRLGD---------------------------------------------- ----------------------RKQEPRVRKSTIEKLKDEIDLVDLLVNTFTSDAVSVTV DILRGIKCNAVAEELLE------------------------------------------- ------------------------------------NTGQVYSIFKLCKKNSHYTKPPII ITDVFMFCFLGGVSQPEPPVPE-------------------------------------- ------------------------------------------------PIPKDPAQLKEL KVTPCSQQFKNKILREKGQ-ETYEIKDKSVRKRLALLINNVDFD-----------DKAMK RSGSEKDEENMEKLLKELDYQVV-KRPNLSAKEMDEAIRDFAQREE--HKYSDSAFVVIM SHG-KR-------DA-IMGVHYHRTNNPSDSFPVDNVYRRLNSENCPALRDKPKVILIQ- -ACRG-------------GEH-GRVW-----ASDGE----------------PDE----- ------------PIEIE--------------DD-DFVHKEKDFISLMSCTP--DT----- --------------------KSYRHVQNGTFYVQTLVDVFIK-------CA--HEDHIEE LFRKVLRRFEHP-----------NMIGNFKQMACKDRATLPKLFYLFPGL---------- ------- >T_nigroviridis_ENSTNIP00000022078 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------MAGEAAGI PELGGEAEGEHRCEDDV-------D-----AKPDRRGRF--LLFKS-KKKNDGQ------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MREQD---Y CSESHY-------RIVSPT-FQYRM--SHQRVGKCIIINNKNFD--EKT-------GMNV RNGTDRDAGELYKCFKSLGFDVF-IYNDQTCEKMEHLLREA-SEED--HSDSSCFACILL SHG-EE-------GM-IYGT-------DG-AMPIKTMTSMFRGDMCKSLVGKPKLFFIQ- -ACRG-------------SEF-DDGI-----QTD-S-----GPPN-DTM----------- ------------ETDAN--------------PR-HKIPVEADFLFAYSTVP--GY----- --------------------YSWRNPGRGSWFVQALCNVLNE-------FG--KQLEIMQ ILTRVNYMVATS---FESWS-EDPRFSEKKQIPCV-VSMLTKELYFKPC----------- ------- >D_melanogaster_FBpp0084848 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MDATNNGESADQVGIRVGNPEQPNDHT DALGSVGSGGAGSSGLV------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------AGSSHPYGSGAIGQLANGYSSPS---S SYRKNVAKM----VTDRHA-AEYNM--RHKNRGMALIFNHEHFE--VP--------TLKS RAGTNVDCENLTRVLKQLDFEVT-VYKDCRYKDILRTIEYA-ASQN--HSDSDCILVAIL SHG-EM-------GY-IYAK-------DT-QYKLDNIWSFFTANHCPSLAGKPKLFFIQ- -ACQG-------------DRL-DGGV-----TMQ-------RSQT-ET------------ ------------DGDSS--------------MS-YKIPVHADFLIAYSTVP--GF----- --------------------YSWRNTTRGSWFMQSLCAELAA-------NG--KRLDILT LLTFVCQRVAVD---FESCTPDTPEMHQQKQIPCI-TTMLTRILRF-SDKQLAPAGRV-- ------- >M_mulatta_ENSMMUP00000001627 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------S-KKKKNVS------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------G-------- QSIKTT-------RDRVPT-YQYNM--NFEKMGKCIIINNKNFD--KVT-------GMGV RNGTDKDAEALFKCFQSLGFDVI-VHNDCSCAKMKDLLKKA-SEED--HTNAACFACILL SHG-EE-------NL-IYGK-------DG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ- -ACRG-------------TEL-DDGI-----QAD-S-----GPIN-D------------- -------------TDAN--------------PR-YKIPVEADFLFAYSTVP--GY----- --------------------YSWRSPGRGSWFVQALCSILEE-------HG--KDLEIMQ ILTRVNDRVARH---FESQS-DDPCFHEKKQIPCV-VSMLTKELYFSH------------ ------- >T_rubripes_ENSTRUP00000040691 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --TNMSANGPSPGGDFT-------D-----AKK--------------GAGQQPR------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SGSSS---G RVTVDA-------KPAAYS-FRYSL--DFPNMGHCIIINNKNFD--RRT-------GMNT RNGTDVDAANAMKVFLSLGYKVK-VHNDQTVNQMKQLLVSA-AEED--HSACASFVCVLL SHG-DE-------GV-FFGT-------DG-SVELKYLTSLFRGDRCKSLVGKPKLFFIQ- -ACRG-------------NDL-DGGI-----ETD-S------------------------ -------------AADS--------------ST-TKIPVEADFLYAFSTAP--GY----- --------------------YSWRNTTSGSWFMQSLCDAISK-------YG--KELELQH ILTRVNHKVAVD---FESVS-NLPGFDAKKQIPCI-VSMLTKEMYFS------------- ------- >A_gambiae_AGAP011950-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MDS----LLELEL-QSYKT--NHPNRGIAVVINDS-----------------EN RDGWEKDLEAVETVLQRLKCDVR-TFCDKTKHEIRDALRNV-SKED--HTKSDCLVIVAM AHG-NN-------DK-ITLR-------RG-EMHIDELWTDFVGNGCPSLIGKPKLVFIQ- -SCRG-------------NKH-DYLV-----GGA-------AVDA-VP------------ ------------SPEKP--------------IC-VEIPMYADLLVMYSSYD--QY----- --------------------VSYRDKEEGSWFIQSLCQVLGA-------NI--AGKDLLT LLTHVSYLVSVRSFLMESEVNMVKRTGVLKQIPSI-NSMLTKAFYFVDK----------- ------- >D_rerio_ENSDARP00000047019 ------------------------------------------------------------ --------------------------------------------MEQKHRQILQRHRLNL VKALNPEDVCDKLLSKGVFT---------------------------------------- ----------------------QDMIDEIQS--KATRRDQARQLVKDLETRGSLAFPAFL DSLRETGHNDLAELLQS-------GDGVHRPPVISVQPSPIPLPVQNLN----------- --------------------------------------------HTEKPDKPDIASPRLV PLRPESLPV--------------------------------------------------- ------------------------------------------------HKTYSPPS---E TVVR--PTR----PRRDSI-QCYKM--DASPCGVCLIINNINFE--KAS-------ELND RKGSNIDCDKLEKRFKALNFEVT-VKRNLKSKRIRHEMASL-AKKD--HSTYDCCVVIIL SHG-TEASHNRFPGA-VHGV-------DGPAVPIQIITNYLNGQNCPSLQGKPKLFFIQ- -ACGG-------------GEK-DIGF---EVSPDDV-----QPSI-GG----IDDEMDAI PMSSSSDSLSTASDELD--------------AR-ASLPTPSDILVSYSTFP--GY----- --------------------VSWRDTEAGSWYVENLDRVLEE-------NA--ITDDLVT MLMLVNDAVSQI-----------SAKGLYKQMPGS-FNFLRKLLYFQSSQS--------- ------- >C_familiaris_ENSCAFP00000023986 ------------------------------------------------------------ --------------------------------------------MDEAERRALRRCRVRL VRELQVAALWDALLSRELFT---------------------------------------- ----------------------AAMVEDLQHAGSGSRSDQARQLVIDLETRGSQALPLFI SCLEDTGQDALASCLTM-------S-----RQAVKQNPE--ATRPLD-LMPVVL------ --------------------------------GPTRLTPEDLR--GKDPSKLTPGKLAPV VLGP-----AELQPQVVRPSVPRP------------------------------------ ------------------------------------------------TDNGSGRF---S DVCE--YQESGWWVAGPIK-LAYAL--NADPCGYCLIINNVNFC--PES-------RLTA RGGSNIDCEKLQRRFCLLRFTVE-VKWDLTAKQMVQALVEL-ARRD--HSALDCCVVVVL SHG-CEASHRQFPGA-VYGT-------DGCPVSIEKIVNIFNGTGCPSLGGKPKLFFIQ- -ACGG-------------EQK-DHGF---AVASASP-----EDRS-PG----SDSEPDAV PFQEGPGP----FDQLD--------------AV-SSLPTPSDIFVSYSTFP--GF----- --------------------VSWRNTKSGSWYVETLDGVFEQ-------WA--HAEDLQT LLLRVANAVSQK--------------GVYKQIPGC-FNFLRKKLYFKM------------ ------- >T_rubripes_ENSTRUP00000031759 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------SMQMAGEPTEI SDLGGEVEEGGQSEDDV-------D-----AKPDRKGRF--LLFKS-KKNKDGQ------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MREQD---Y CSESHY-------RIVSPT-FQYKM--SHQRVGKCIIINNKNFD--EKT-------GMNV RNGTDRDAGELFKCFKTLGFDVF-IYNDQTCEKMERLLREA-SEED--HSDSSCFACILL SHG-EE-------GM-IYGT-------DG-AMPIKTMTSMFRGDMCKSLVGKPKLFFIQ- -ACRG-------------SEF-DDGI-----QTD-S-----GPPN-DTM----------- ------------ETDAN--------------PR-HKIPVEADFLFAYSTVP--GY----- --------------------YSWRNPGRGSWFVQALCNVLSE-------FG--KQLEIMQ ILTRVNYMVATS---FESWS-EDPRFSEKKQIPCV-VSMLTKELYFKQC----------- ------- >C_intestinalis_ENSCINP00000024485 ------------------------------------------------------------ EFRLLLHQICEGLTGENVSMMKFLCKDAIPRSR--ELETALDFMEYFEAKGWIQEGDLGF LAEVLYRINRHDLLKLLPGVKNRRDYEENFQAQQNNFTTYR------------------- ----------------------VVCFMLADELTEGDLKILKRLCAGKMSKANVRRSVDVL SWLTCMEEEDLLSEGDL-------D-----FIMSILQHL--DNQKPYKLFQRVR------ ---------------------------------------------------MNDNTVTLP KNQQKSNAFQPNSHLPVASGFNSLSKQEYNHTSKLEPQYVSMENHRA------------- ------------------------------------------------FNGGYNQY---N NYQSEIKDT----STMGIL-DKYPM----ERRGYCLIINNENFE--R-----------QD RTGSGNDTERLENLFKEFGFILD-VRKDLDQREMEKVIQEY-TKKD--HSDKDCFVCVVM SHG-LS-------GC-VYGV-------DGLSLSTSKISKSFRPGMCSSLTGKPKIFFFQ- -ACQG-------------DRT-MDGH---SAPVD-D-----VESD--------------- ------------GAASH--------------GR-QVLPSESDFLIGHSTVP--GY----- --------------------LSYRSRTDGSWFISTLVDSLEK-------YH--EKEDLLS IMINVNQEMASK---------------PYKQMPMP-IATLRKKVFF-SKQNSNSSSNQNC NTP---- >A_gambiae_AGAP011952-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------ENYDT--SHRNRGTALIFNHVNFE------------SNAK REGSNKDRDEIKKELLQLGFDAR-VFNDLKKQELLAKLDEV-AKED--HTESDCFVLVMM THG-QD-------GS-LYAA-------DK-QYQIAELWEPFVGDACKTLIGKPKLFFVQ- -ACRG-------------TKF-DKGVKLTKIATD-T-----VDAL--------------- ------------SSSSQ--------------RT-CVIPTMADVLVMYSAFD--GH----- --------------------YSWRNPTHGSWFIQSLSIELNQ-------HA--HRKELLQ LLTSVSRRVAYL---YESNVPGNEQMDGKKQMPCV-VSMLTKALYF-PRK---------- ------- >C_familiaris_ENSCAFP00000017899 -----------------------------------------------------------M DFSKCLYNIGEQLDSDELASLKFLSLDYIPQKKQEPIKDPLMLFQRLQEKRMLEESNLFF LKELLFRINRLDLLMTYLDTSKEDMQQELQIPGRAQISAY-------------------- ------------R---------VMLFQISEDVSKLELKSFKFLLSREISRCKLDDDLNLL DIFIEMEKRVILGERNL-------D-----TLKRICDQ---INKSLLKKITDYEELN--- -----------------------------------------REQTMNLQRSLDEISNDMS QLPIR-EGSVKILPMSD--SLGEQD----------------------------------- ---------------------------------------------------YESE----- ----------------TSD-KVYRM--KSKPRGYCLIFNNYDFS--VARREVPKLQSIKD RNGTDLDADALSKTFSELHFEIV-HFKDATAKKICEVLQSY-QSMD--HSSKDCFICCIL SHG-DK-------GI-IYGS-------DGQEAPIYELTSYFTGSKCPSLAGKPKIFFIQ- -ACQG-------------DKY-QKGI---AVETD-S-----EQKE-AY----LEM----- ------------D-SSY--------------QK-RYIPEDADFLLGMATVN--NC----- --------------------VSYRNPMEGTWYIQSLCQSLRE-------RCP-RGEDILT ILTEVNFEVSNK--------DD--RKNMGKQMPQP-TFTLRKKLFF-PP---N------- ------- >A_gambiae_AGAP011949-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MDS----ILEFEL-KSYDT--THPNRGIAVVINDS-----------------ER REGSEKDVQDVVATLEGLKFNVR-TFQDNTKKEIKKALYKV-ARED--HNENDCLVIVAM AHG-KK-------DH-ITLK-------KE-KLRIDKLWASFVGNKCPSLIGKPKLVFIQ- -TCRG-------------DNV-DFGV-----ASH-------ETDS-TP------------ ------------CSVDP--------------AP-GIIPMYADLLVMYSSYD--RH----- --------------------ISVRCKDKGSWFIQSLCQVLRA-------NI--AGKELIS LLTQVSYIVSCQ-------TSITSDGETVKQIPSI-NSMLTKAFYFVPKQTQQIS----- ------- >G_aculeatus_ENSGACP00000022402 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MSVNGPGEDRT-------D-----AKT----------------EQSEV------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SSSAS---A PEEVDA-------KPNVHS-FRYSL--SFPSIGQCIIINNKNFD--RGT-------GMNQ RNGTDVDAANAMKVFGNLGYKVK-VYNDQSVAQIQHVLTSV-SKQD--HSCSASFVCVLL SHG-DG-------DL-FFGT-------DG-PVPLKSLTSLYRGDRCKSLVGKPKLFFIQ- -ACRG-------------TEL-DPGI-----EAD-S------------------------ --------------VKD--------------ET-TRIPVEADFLYAFSTAP--GY----- --------------------YSWRNTTTGSWFMQSLCDMISK-------YG--KELELQH IMVRVNHKVAVA---FESVS-NSPDFNARKQIPCV-VSMLTKEMYFSP------------ ------- >T_nigroviridis_ENSTNIP00000001216 ------------------------------------------------------------ --------------------------------------SAYQLFLSLCDQDHLSEERPHL LSELLSIIQRTRLL-RDLDLRSSATSNL--------ISAY-------------------- ------------R---------KLLYSLSEDLTDDNLKEIKFLLTETLPRRKLEDNVTTL EVFLELECMDLLSKTNL-------G-----LLKSILQP---VCPVLAERIRQFEAQN--- ----------------SCQPAADWGFAVKKITDPLQVQ--------GGSDAL---PSLPE ENQSSSRTEASVMSSANAVGIKPGT----------------------------------- ---------------------------------------------------LMLGL---S PPPVGSPNF----P-VQDL-GTYPM--TTLPRGCCLIISNYDFQ--GS--------GLGM RNGTRTDEECLKKVFEWLGFKVE-IHRDCTGKEILSLMQEL-ADKS--QQRWDCLVCCIL SHG-LE-------GC-VHGV-------DGDQVSIKKLIEPFLGTNCPAMAGKPKLFFIQ- -ACQG-------------KKQ-QGVV---HLESD-G-----AEHS-DV----D-T----- ------------D-AVR--------------LS-NCIPSHADFLLGMATVP--DY----- --------------------VSYRDRERGTWYIQSLCEYLVK-------MVP-RGFDLMS ILTKVNEDVSKK--------ND--NTGDRKQMPQP-VFTITKRIVF-PVPSGPAPVLPHF PFVEDSP >A_gambiae_AGAP004920-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------VCGRDILHCKTMNTSTLS TAFDEVDNNTRVLSLVASVP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E IISSSVIHE----LEPVDD-AHYNM--SHNRRGVAAVFNHRKFL------------HASE RKGTDADCDNIRQVLIYLQFEVR-VYDDLTRKEIKQVLDDL-AEED--HKNSDCLLVVIM THG-DD-------DV-LHAK-------DG-TFNVDRLWENFIGDSCPSLLGKPKLFFIQ- -ACRG-------------SSF-DTGVHFSQCMTQVAKTVVPYAMRELPQPSIVPG----- ------------CPKSS--------------IQ-YAIPSMADLLVMYSTYK--GH----- --------------------YSWRNPSTGSWFIRALCDELRE-------HG--NSKELLQ LLTSVSRRVAYE---FQSNVPNNSQIDCQKQMPCI-VSMLTRRIYF-SKK---------- ------- >X_tropicalis_ENSXETP00000003217 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --MEESHNGVQYGEDTA-------D-----AKT--------------YFTNQQI------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SLQNC---D IKDMEK------KTKFAHL-HKYRT--DYPEMGICLIINNKNFQ--SST-------NMGV RNGTDVDARKLHETFTGLGYKVK-VCNDQKSNDIFTLLKKM-SEED--HSKRSSFVCAIL SHG-ED-------GL-VYGV-------DG-PIQIKNLTDLFRGDRCKTLVGKPKLFFIQ- -ACRG-------------TDL-DSGI-----ETD-S-----GS----------------- -------------EPGE--------------EI-QRIPVEADFLYAYSTVP--GY----- --------------------YSWRNTMNGSWFIQSLCEMIKL-------YG--PHLELIQ ILTCVNHMVALE---FESCS-TQQAFHAKKQIPCV-VSMLTKAFYF-LK----------- ------- >O_latipes_ENSORLP00000010095 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MASNRPGEDST-------D-----ARK--------------DNGELAA------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GASPAP---D RMDVDG-------KPSSHS-FRYSL--NFPTIGLCIIINNKNFD--RGT-------GMNQ RNGTDIDAASAMKVFSKLGYRVK-IYNDQTVKQIKQLLTDV-SRMD--HSDSASFVCILL SHG-DE-------GV-FFGT-------DG-SIELKTLTSLFRGDHCKSLVGKPKLFFIQ- -ACRG-------------TEL-DDGI-----EAD-S------------------------ ---------------KE--------------DT-TKIPVEADFLYAFSTAP--GY----- --------------------YSWRNTMTGSWFINSLCEMLSK-------YG--KELELLH IMTRVNHMVAVE---FESIS-TLPGFHAKKQIPCI-VSMLTKEMYFYP------------ ------- >T_rubripes_ENSTRUP00000024164 ------------------------------------------------------------ -----------------------------------------VFLPKDMEAVRRNKTAIGT IFCADYGLILNKVDEKKLIT---------------------------------------- ----------------------RRDYNNLKNINGEDIWGHVIALVDKIMNKGDATCEAFL NLLQTDDDIKSTYPELKDTHFNIFF----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------FFYLQD-EQYEL--LSQPTGLCVIINNENFL------------DMKQ RSGTNKDAQSLAEVFTWLGFRVL-MCKDQTKEKMDRALNCFASLVD--PKHGDAFICCIL SHG-EK-------SA-VLGI-------DGEPLCIKQIIRTFKATRQSALVSKPKMFLIQ- -ACQG-------------KGT-HRGV---LLKDL-------------------------- ------------QTDDC--------------HT-LSIPEEADILVATATVE--DY----- --------------------VSFRHKIDGSWFIQSLCQELKE-------GCL-RGEDMTT ILHRVNSEVSQK--------EAFIHPGEQKQMPEV-RFTLRKRLVLSPHTA--------- ------- >O_anatinus_ENSOANP00000006351 -----------------------------------------------------------M DFHRLLFSIGEELAADDLEALKFLCLDLIPRKKQENIQDALGLFRLLQEKGMLEEGKLFF LKELLFRIHRIDLLTSHLRTSQEDVARELEEPGRAQVSAYS------------------- ------------R---------VLLFTLSDNVTREELKSITFFLSNDLPRSRLDNKQTLM GIFIEMEKKGILGESNL-------D-----MLKKICDK---IDKTLLGKIDHYEERR--- -----------------------------------------ADCTLHSSEHLTVLDRDMY IIPIIYDEIILLPTESS--FRGHSG----------------------------------- ---------------------------------------------------GEAE----- ----------------QNG-DFYKM--NSNPRGYCLIINNYNFQ--QARAEVPKLKKMKN RDGTDKDAEALSQIFKALAFSPV-VFEDQTAEQILETLQSY-QRMD--HSAQDCFVCCIL SHG-DR-------GV-VYGT-------DGQQASIRSLTSYFTGSRCPTLAGKPKLFFIQ- -ACQG-------------DAY-HLAV---ALETD-NGTDKGTAAA-SP----AEP----- ------------D-AVF--------------HE-RCIPDEADFLLGMATVS--NC----- --------------------VSYRIPSKGTWYIQSLCHHLRN-------LCP-LGADILT ILTKVNFEVSQK--------ID--LTNRGKQMPQP-MFTLRKKLVL-PL---L------- ------- >M_musculus_ENSMUSP00000030747 ------------------------------------------------------------ --------------------------------------------MDEADRQLLRRCRVRL VSELQVAELWDALLSRELFT---------------------------------------- ----------------------RDMIEDIQQAGSGSRRDQARQLVTDLETRGRQALPLFI SCLEDTGQGTLASLLQS-------G-----RQAAKQDPE--AVKPLDHLVPVVL------ --------------------------------GPMGLTAKEQRVVKLDPSQPAVGNLTPV VLGPEELWPARLKPEVLRPETPRP------------------------------------ ------------------------------------------------VDIGSGGA---H DVCV--PGK----IRGHAD-MAYTL--DSDPCGHCLIINNVNFC--PSS-------GLGT RTGSNLDRDKLEHRFRWLRFMVE-VKNDLTAKKMVTALMEM-AHRN--HRALDCFVVVIL SHG-CQASHLQFPGA-VYGT-------DGCSVSIEKIVNIFNGSGCPSLGGKPKLFFIQ- -ACGG-------------EQK-DHGF---EVACTSS-----QGRT-LD----SDSEPDAV PYQEGPRP----LDQLD--------------AV-SSLPTPSDILVSYSTFP--GF----- --------------------VSWRDKKSGSWYIETLDGILEQ-------WA--RSEDLQS LLLRVANAVSAK--------------GTYKQIPGC-FNFLRKKLFFKTS----------- ------- >D_rerio_ENSDARP00000019984 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MDKEALTSENEVSGDDQENYGKGDVTDAKPDPKAMCRVDKE-ALTSE IEVLEEDQDSYGEEDVT-------D-----AKPDRKGRF--RLFGN-FKKNDGK------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------LQEKG---- ESESHY-------RIVSPT-FQYKM--SHQRVGKCIIINNKNFD--EKT-------GMNV RNGTDRDAGELFKCFKSLGFDVA-VYNDQTCRNMERLLKAV-SEED--HSDSSCFACILL SHG-EE-------GM-IYGT-------DG-AMPIKTMTSLFKGDVCKSLVGKPKLFFIQ- -ACRG-------------SEF-DDGV-----QTD-S-----GPPN-DTI----------- ------------ETDAN--------------PR-HKIPVEADFLFAYSTVP--GY----- --------------------YSWRNPGRGSWFVQALCNVLSE-------FG--KQLEIMQ ILTRVNYMVATS---FESWS-EDPRFSEKKQIPCV-VSMLTKELYFN------------- ------- >G_aculeatus_ENSGACP00000005791 -----------------------------------------------------------M HFQKLLFDIGKALSGEEVKALAFLCTDILG-RNLSSVESASGLFSRLRDQGFLSAEQPHL LTELLIIIQRVRLT-RDVDLPAEP---------SSLISPY-------------------- ------------R---------KMLYNLSEELTADDLKDMKFLLHSYLPRRKLEENVSTL EIWLEMEHKDLMNEHNL-------H-----LLEILISK---VCPMLKDKINQLKAQQ--- -----------------------------------ETPTSPATQESGRQGSLSAPNAPNQ VPQSLGAEGTGLFEMQDSPSGFNGGGDCAALSLGLSGHLKIEVVETM------------- ------------------------------------------------PPPKNMSC---S EPPTSQPSD----TNTEVL-GTYPM--TSAKRGICLIVNNFDFT--K-------FKNYQN REGTMKDEERLHKVFAWLGFEVE-VKHDCEGEQMLTALREL-ASRN--HGQADCLVCCVL SHG-DE-------GC-VYGV-------DGHTVAIKELKEPFNGLNCASLAGKPKLFFIQ- -ACQG-------------TGE-QKAV---NVVPD-G-----PEDS-AV----C-S----- ------------D-AFK--------------AS-DAIPSEADFLLGMSTVP--SF----- --------------------VSYRHRKNGSWFIESLCQNLVQ-------MVP-KL----- ------------------------------------------------------------ ------- >C_familiaris_ENSCAFP00000016791 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SSATCGLRRAYRTAD---E QNVTETDAFYK-REMFDPE-EKYKM--DHKRRGIALIFNHERFF--WHL-------TLPD RRGTSADRDNLVRRFSELGFEVK-CFNDLKAEELLLKIHEA-STSS--HIDADCFLCVFL SHG-EG-------NH-IYAY-------DA-KIEIQTLTGLFKGDKCQSLVGKPKIFIIQ- -ACRG-------------DQH-DVPV----LPLD-V-----VDHR-TDKLEDNVT----- ------------EVDAA--------------SV-YTLPAGADFLMCYSVAE--GY----- --------------------YSHRETVNGSWYIQDLCEMLGK-------FG--SSLEFTE LLTLVNRKVSQR---RVDFC-KDPNAIGKKQVPCF-ASMLTKKLHFFPKSK--------- ------- >C_intestinalis_ENSCINP00000003204 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MSLKSAADVLMSGVPTPHTNENNNVG QSEVD------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------ALGSGETP---R IYSLPDVTK----MASSEV-ECYQM--DRESRGLALIINNENFH--HAT-------RMNK RSGTDVDARNLSRIFKKLGFDVQ-VYKDLSCISMLEVINEV-STMD--HTGNDCCFVAFL SHG-DD-------GC-VYGT-------DG-IVQIKKIVDQFRGDVCPSLAGKPKIFLFQ- -ACRG-------------TLH-ETSV---QLSVD-VVDGEDQPCV--------------- ------------EVDAA--------------PV-PTLPSGSDYLFCYSVAE--GY----- --------------------YSHRDTLYGSWFIQDFTDVMEQLVLNKGKQQ--DKVDFID VLTVVNRKVSAR---RVERS-YSQQALGKKQMPCY-LSMLTKKLYLTPKK---------- ------- >G_aculeatus_ENSGACP00000008661 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QVNGA-RLTSA QDVA--AEEGGPTGDQT-------D-----AKPDRRGRF--LLFGNIKKNKDGQ------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TREQD---Y SSESHY-------RVVSPT-FQYKM--SHQRVGKCIIINNKNFD--EKT-------GMNV RNGTDRDAGELFKCFKSLGFDVF-IYNDQTCGKMESLLREA-SEED--HSDSSCFACILL SHG-EE-------GM-IYGT-------DA-AMPIKSMTSLFRGDMCKSLVGKPKLFFIQ- -ACRG-------------SEF-DDGI-----QTD-S-----GPPN-DTL----------- ------------ETDAN--------------PR-HKIPVEADFLFAYSTVP--GY----- --------------------YSWRNPGRGSWFVQALCNVLNE-------FG--KQLEIMQ ILTRVNYMVATS---FESWS-EDPRFSEKKQIPCV-VSMLTKELYFN------------- ------- >E_caballus_ENSECAP00000015102 ------------------------------------------------------------ --------------------------------------------MNEADRQLLRRSRLRL VRELQVDSLWDALLTRELFT---------------------------------------- ----------------------PDMIEDIQR--SGSRRDQARQLIIDLETRGSQALLLFI SCLEDTGQDTLASFLRT-------S-----SQAAKQNPE--AIRPSD-LPPVVL------ --------------------------------GPVGLKPEELTAVKQDPSKLTPGKLTPV VLGPEELWLAKLRPEVLRPEVPRP------------------------------------ ------------------------------------------------VDIGSGGF---S DVRA--QDR----LRGNAD-LAYVL--NADPCGHCLIINNVNFY--LAS-------GLGR RVGSDIDCEKLRQRFSLLHFMVE-VKGDLTAKQMLRALGEL-ARRD--HGALDCCVVVIL SHG-CQASHLQFPGA-VYGT-------DGCPVSIESIVNIFNGTGCPSLGGKPKLFFIQ- -ACGG-------------EQK-DPGC---KVDSTSP-----EDRT-PG----SDSEPDAV PFQEGPGT----FDQPD--------------AV-SSLPTPSDIFVSYSTFP--GF----- --------------------VSWRDPKSGSWYVETLDGVFEQ-------WA--HSEDLQT LLLRVAHAVSEK--------------GVYKQIPGC-FNFLRKKFFFKTY----------- ------- >B_taurus_ENSBTAP00000003205 ------------------------------------------------------------ --------------------------------------------MNEADRLLLRRYRVRL VGELQVASLWDALLSRELFT---------------------------------------- ----------------------PDMIEDIQRAGSGSRRDQARQLILDLETRGSQALPLFI SCLEDTGQDTLASLLKT-------S-----RQAAKQ------------------------ -------------------------------------------------SKPSQGKLAPV VLGPEELWPAKLRPEVLRPEVPRA------------------------------------ ------------------------------------------------VDAGSGGF---T DVCP--QDR----AKGNAD-LAYVL--NADPCGHCLIINNVNFC--RES-------GLRA RTGSNIDCERMRQRFHLLQFVVE-VKCDLTAKQMVQALMQL-ARQD--HSALDCCVVVIL SHG-CQASHLQFPGA-VYGT-------DGCPVSVERIVNTFNGTGCPSLRGKPKLFFIQ- -ACGG-------------EQK-DHGF---EVESTSP-----EDKT-PS----SDPEADAT PFQEGPRS----IDEPD--------------AV-SSLPTPSDILVSYSTFP--GF----- --------------------VSWRDPKSGSWYIETLDSIFEQ-------WA--HCEDLQT LLLRVANAVSVK--------------GIYKQMPGC-FNFLRKKLFFKT------------ ------- >G_aculeatus_ENSGACP00000007379 ------------------------------------------------------------ --------------------------------------------MEEIHKRILQRNRINL VRDLDPSSLYDGLLEKGVFT---------------------------------------- ----------------------QDMIDEIKS--AGTRRDQARKLVQDLETRGSRAFAMLL LCLEETDQHGLAELLQR-------A-----APAVQIWP----AAPNQPFVLMLN------ --------------------------------------------SREKTTSPSIQYRNPV PVHLTHCD---------------------------------------------------- ------------------------------------------------AHVTAPER---E NTLTRPPGR----TRRDSI-QSYKM--DASPCGHCLIINNVEFE--PDS-------ELSN RKGSNIDCDKLEKRFKALNFIVE-VRTNLKQRQIKHALSAL-SKKD--HSQCDCCVVIML SHG-TEVSHNRFPGA-VYGV-------DGQHVPVQLITNYLNGQHCPSLQGKPKLFFIQ- -ACGG-------------GER-DTGF---EVSPDEV-----EPSI-GG----ADDQTDAI PMSSSSDSLSL-SDEVD--------------AR-ATLPTPSDILVSYSTFP--GY----- --------------------VSWRDTQSGSWYVETLDQVLEQ-------NA--ATDDLVT MLMMVNHEVSQN-----------SAKGLYKQMPGS-FNFLRKLLHFQTHA---------- ------- >C_elegans_C48D1.2 ------------------------------------------------------------ -------------------------------------------MMRQDRRSLLERNIMMF SSHLKVDEILEVLIAKQV------------------------------------------ ----------------------LNSDNGDMINSCGTVREKRREIVKAVQRRGDVAFDAFY DALRSTGHEGLAEVLEPLARSVDSN-----AVEFECPMS--PASHRRSRALSPA------ -----------------------------GYTSPTRVHRDSVSSVSSFTSYQDIYSRARS RSRSRALHSSDRHNYSSPPVNAFPSQPSSANSSFTGCSSLGYSSSRNRSFSKA------- ------------------------------------------------SGPTQYIF---H EEDMNFVDAPTISRVFDEK-TMYRN--FSSPRGMCLIINNEHFE------------QMPT RNGTKADKDNLTNLFRCMGYTVI-CKDNLTGRGMLLTIRDF-AKHE---SHGDSAILVIL SHG-EE-------NV-IIGV-------DDIPISTHEIYDLLNAANAPRLANKPKIVFVQ- -ACRG-------------ERR-DNGF-PVLDSVDGVPAFLRRGWD-NR----DGPLFNFL GCVR--------PQVQQ--------------VW-RKKPSQADILIAYATTA--QY----- --------------------VSWRNSARGSWFIQAVCEVFST-------HA--KDMDVVE LLTEVNKKVACG---FQTSQ----GSNILKQMPEM-TSRLLKKFYFWPEARNSAV----- ------- >A_gambiae_AGAP009832-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------QPLTKAFSAMFSR KQEDSSDTRGMPHGSPI------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------ASGSQ---T ANGIIRPAY----VIERYA-AYYPM--NHKRRGMALIFSHNKYN--VRNV------SLPV REGSAIDCKRLKETLELFRFDVK-VYPDFKLEEIKSVIGKV-SSMD--HSDSDCFLVAIL THG-ED-------GGIVYAY-------DQ-PYELSLIWSFFTADNCPSLAGRPKIFVVQ- -ACRG-------------NQL-DHGV-----KV--------------------------- ------------QKDGV--------------AR-YSIPTHADFLFAYATIP--GF----- --------------------MAFRNTTEGSWFINELCKELQE-------NG--HRYDINT LLTFVTQKVAYD---HESVS-NMPEYNMRKQTPCV-VSMLTRLLLF-NVV---------- ------- >D_rerio_ENSDARP00000093958 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------M--KHAKRGLALIFNQKDFS--LL--------GLKT RKGTDKDRDSLVSRFEELDFEVK-AYNDYSRDKVLKEIKEV-AAAD--HVDADCFVCIFL SHG-ED-------GH-VYAN-------DE-KIKIPEITDLFKGDKCRGLVGKPKIFIWQN KACRG-------------DKK-DDPV-----APMSA-----EDSDDEM------------ ------------AVDAG--------------VS-NTLPAGADFIMCYSTTE--GF----- --------------------CSFRDPLNGTWYIQDLCEIMGR-------YR--SQLEFTN ILTLVNRKVSLR------SICDDLSATGTKQMPCF-ASMLTKRLFFRPKK---------- ------- >C_familiaris_ENSCAFP00000032442 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M AHGGPQ-------GQ-LLGA-------DGQEVQPEALVQELN--RCRALWGCPKIFLLQ- -ACRG-------------GHR-DAGV-----GPTAL----------------SWF----- ------------RRWLR--------------AS-PTTPSHADVLEIYTDAQ--GGVCLPL EPGLGRPGG-----RAVWRCVAYRD-EKGSDFIQTLAEVLRA-------D---PGGDLLE LLTEVNRRVCEL------DVLGPDCPERRKACLEI-RSSLRRPLCL-------------- ------- >G_gallus_ENSGALP00000002083 ------------------------------------------------------------ --------------------------------------------MEEAQRSALRRGRVRL VEGLRPEVLWGPLQARGVFT---------------------------------------- ----------------------SAMVEDMQS--TGTRREQARQLVIDLETRGKQAFPIFL SILRDTGHGDLADMLDE-------G-----CGSPMSPPV--DLRPVQ------------- ------------------------------------------------------------ ------LELPGERRDKSVSTAERLSI---------------------------------- ------------------------------------------------PVQPESER---F RMPPAPAQACPTGLAGECS-EVYQL--RADPCGHCLIFNNVSFS--RDS-------DLST RAGSDIDCEKLEKRFRSLCFHVR-TLRNLKAQEIDVELRKL-ARLD--HSALDCCLVVIL SHG-CQTSHIQFPGG-IYGT-------DGKIIPIERIVNYFNGSQCPSLRGKPKLFFIQ- -ACGG-------------EQK-DQGF---EVDCESP-----QDET-CR----RSIESDAI PFQAPSGN----EDEPD--------------AV-ASLPTPGDILVSYSTFP--GF----- --------------------VSWRDKVSGSWYVETLDSVLEH-------YA--RSEDLLT MLLRVSDIVSTK--------------GRYKQIPGC-FNFLRKKFFFLCK----------- ------- >A_gambiae_AGAP012544-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MDATIINNN HSSLEAMDS----TLQLTL-HSYNM--AHPKRGIAVVINNN-----------------RD RKGSEKDVKALQAVLSHLQFDVR-LLSDKTTVEIRHALKEV-SKED--HTNNDCLAIIAM AHG-YN-------DR-IKFD-------DD-YLHIDELWTNFVGNKCPSLIGKPKLVFIQ- -SCRG-------------GKL-DYGA-----SIA-------TADA-RP------------ ------------GLEEP--------------VD-VKIPMYADLLVMYSSFE--HH----- --------------------SSIRCRNEGSWFIQSFCQVLGA-------NI--AKTELQA LLCHVSYLVSIR-----SDQTIDPEGKVVKQIPMV-TSMLTKAFYFVPK----------- ------- >D_rerio_ENSDARP00000075318 ------------------------------------------------------------ --------------------------------------------MADQLLENLRPDLIKG LSERVINGLLDDLQQKKVF----------------------------------------- ----------------------GEEEIEDIQHRMKTRADQARHVIDDVKRKGVKASEIML ASLKTRDPHLYDTLGIE------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------RLLVPVPETE---L TPSQLSETTGCSTDKTNTM-NEYEM--KSNPRGLCLIFNNENFK-----------DPDMK RHGSQMDTASLKDLFEWLGFSVE-IKQDQTVSAMKRTLKEY--SED--RKHGDCFVCCVL SHG-NE-------SG-VLGS-------DEKICPVDDITSPFNGANCSSLAGKPKVFFIQ- -ACRG-------------HEI-QSKV---MVADGSG-----GSRT--------------- ------------QKPGR--------------VS-VSIPKDSDFLIARSTVE--GY----- --------------------VSIRDRTSGTWFIQSLCENLKE-------GSK-RGHDILM ILTKVNNDVSRK----EGSLKVKNEIVDAKVTPQP-IFTLRKLLIFRPLKKTGRFS---- ------- >R_norvegicus_ENSRNOP00000017972 ------------------------------------------------------------ --------------------------------------------MEEADRQLLRRCRVRL VRELQVAELWDALLSRELFT---------------------------------------- ----------------------RDMIEDIQRAGSGSRRDQARQLVIDLETRGRQALPRFI SCLEDTGQGSLASFLQS-------S-----GQAAKQDPE--AVTPLDHLVPVVL------ --------------------------------GPMGLKSKEQKVVKLDPSQPALGNLTPV VLGPEELWPTRLRPEVLTPETPRP------------------------------------ ------------------------------------------------VDIGSGRA---H DVCT--PGK----IERHAD-MAYTL--DSDPCGHCLIINNVNFC--PSS-------GLST RIGSHVDCEKLQHRFCWLRFMVE-VKNDLTAKKMVTALMEM-AHRD--HRALDCFVVVIL SHG-CQASHLQFPGA-VYGT-------DGCSVSIERIVNIFNGTGCPSLGGKPKLFFIQ- -ACGG-------------EQK-DHGF---EVAFTSS-----QDKA-FD----SDSEPDAV PYQEGPRT----LDQLD--------------AV-SSLPTPSDILVSYSTFP--GF----- --------------------VSWRDKKSGSWYIETLDGVLEQ-------WA--RSEDLQS LLLRVANAVSEK--------------GVYKQIPGC-FNFLRKKLFFKLH----------- ------- >H_sapiens_ENSP00000286186 ------------------------------------------MKSQGQHWYSSSDKNCKV SFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFF LAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFR------------------- ----------------------NLLYELSEGIDSENLKDMIFLLKDSLPKTE----MTSL SFLAFLEKQGKIDEDNL-------T-----CLEDLCKT---VVPKLLRNIEKYKREK--- -------------------AIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQ---E SWQNKHAGSNGNRATNGAPSLVSRG----------------------------------- ------------------------------------------------------------ -MQGASANTLNSETSTKRA-AVYRM--NRNHRGLCVIVNNHSFT------------SLKD RQGTHKDAEILSHVFQWLGFTVH-IHNNVTKVEMEMVLQKQKCNPA--HADGDCFVFCIL THG-RF-------GA-VYSS-------DEALIPIREIMSHFTALQCPRLAEKPKLFFIQ- -ACQG-------------EEI-QPSV---SIEAD-A-----LNPE--------------- ------------QAPTS--------------LQ-DSIPAEADFLLGLATVP--GY----- --------------------VSFRHVEEGSWYIQSLCNHLKK-------LVP-RHEDILS ILTAVNDDVSRR--------VD--KQGTKKQMPQP-AFTLRKKLVF-PVPLDALSL---- ------- >P_pygmaeus_ENSPPYP00000014602 ------------------------------------------MKSQGQHWCSSSDKNCKV SFREKLLIIDSNLGVQDVENLKFLCVGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFF LAELLYIIRQKKLL-QHLSYTKEEVEGLL--PTRQRVSLFR------------------- ----------------------NLLYELSEGIDSENLKDMIFLLKDSLPKTE----MTSL SFPAFLEKQGKIDEDNL-------T-----CLEDL-KT---VVPKLLRNIEKYKREK--- -------------------AVQIVTPPIDKEAESYQGEEELVSQTDVKTFLEALPQE--E SWQNKHAGSNGNRATNGAPSLVSRG----------------------------------- ------------------------------------------------------------ -MQGASANTLNSETGTKGR-KGYRM--NRNHRGLCL-LNNHSFT------------SLKD RRGTHKDAEILSHVFQWLGFTVH-IHNNVTKGEMEEVLQEQKCNPA--HADGDCFVFCIL THG-KF-------GA-VYSS-------DEALIPIREIMSHFTALQCPRLAEKPKLFFIQ- -ACQG-------------EEI-QPSV---SIEAD-A-----LNPE--------------- ------------QPPTS--------------LQ-DSIPAEADFLLGLATVP--GY----- --------------------VSFRHVEEGSWYIQSLCNHLKK-------LVP-RHEDILS ILTAVNDDVSRR--------VD--KQGTKKQMPQP-AFTLRKKLVF-PVPLDALSL---- ------- >P_pygmaeus_ENSPPYP00000014606 -----------------------------------------------------------M DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQS VPFWWRVDHILIR---------VMLYQISEEVSRSELRCFKFLLQEEISKCKLDDDMNLL DIFIEMEKRVILGKGKL-------D-----ILKRVCAQ---INKSLLKIINDYEEFS--- -----------------------------------------RG----------------- ------EELCGVMTISD--SPREQD----------------------------------- ---------------------------------------------------SESQ----- ----------------TLD-KVYQM--KSKPRGYCLIINNHNFA--KAREKVPKLHSIRD RNGTHLDAGALTTTFEELHFEIK-PHNDCTVEQIYEILKIY-QLMD--HSNMDCFICCIL SHG-DK-------GI-IYGT-------DGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQ- -ACQG-------------DNY-QKGI---PVETD-S-----EG-Q-PY----LEM----- ------------DLSSP--------------QT-RYIPDEADFLLGMATVN--NC----- --------------------VSYRNPAEGTWYIQSLCQSLKE-------RCP-RGDDILT ILTEVNYEVSNK--------DD--KKNMGKQMPQP-TFTLRKKLVF-PS---D------- ------- >A_aegypti_AAEL014348-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------MKKIMFGR KEVNSPQ----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------Q MIPTVAPAY----TIERYS-AYYPM--NHKHRGKAIIFAHSVFA--VKNV------NLPN RDGSDVDCEMLVESLKRLHFDVT-LYKDYRLKDILLVIEKV-SLMD--HSNSDCLLVAVL SHG-DE-------GEVIYAH-------DC-PYQISSIWTQFTGDRCRTLVGKPKIFIIQ- -ACRG-------------NDL-DSGV-----KVE-------------------------- -------------KDGV--------------AR-YSIPTNADFLFAFATIP--GY----- --------------------MSFRNTKNGSWFIRELCNELNE-------NG--QRYDMLT LLTFVVQKVAYG---YESYAPVHPDHHMKKQTPCV-VSMLTRLLLF-NNV---------- ------- >M_musculus_ENSMUSP00000029626 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --MTETDGFYKSREVFDPA-EQYKM--DHKRRGVALIFNHERFF--WHL-------TLPE RRGTNADRDNLTRRFSDLGFEVK-CFNDLRAEELLLKIHEV-STSS--HIDADCFICVFL SHG-EG-------NH-VYAY-------DA-KIEIQTLTGLFKGDKCQSLVGKPKIFIIQ- -ACRG-------------SQH-DVPV----VPLD-M-----VDHQ-TDKLD-NVT----- ------------QVDAA--------------SV-YTLPAGADFLMCYSVAE--GY----- --------------------YSHRETVNGSWYIQDLCEMLAR-------YG--SSLEFTE LLTLVNRKVSQR---RVDFC-KDPDAIGKKQVPCF-ASMLTKKLHFCPKPSK-------- ------- >O_latipes_ENSORLP00000003208 ------------------------------------------------------------ --------------------------------------------MEEKHKRILRRNRVHL VKELDLSDLCDVLLRKDVFT---------------------------------------- ----------------------QSMINDIKRQNCETKRDQARKLVKDLETRGNEAFSAFL EGLRVTGQQNLLELLQK-------S-----APRVHFQP-GKSTEAGYLLIQPHP------ ----------------------------------VYIEDAVPKKPRTQPSPRKRERRGGG VKVPHNIFIDKVKSDIFDSKSRFR------------------------------------ ------------------------------------------------NNDNTNVC---T HLTRCSRGQ----RSDHDG-TASRM--DARPCGLCLIINNVEFE--PKT-------ELSI RKGSNVDCDKLEKRFKSLNFVVE-VRTNLKQRQIKSELSAL-SRKD--HSIYDCCVVVIL SHG-TEVSHNRFPGA-VYGV-------DGNHVSVQEITNYLNGQNCPSLQSKPKIFFIQ- -ACGG-------------GEK-DIGF---EVSPDEA-----KPSI-GG----DGDQTDAI PFSSSSESLST-SDETD--------------AI-PTLPTPSDILVSYSTFP--GY----- --------------------VSWRATVSGSWYVEVLDNILEE-------HA--ATLDLTT MLTLVNDKVSQN-----------SAKGLYKQMPGS-FNFLRKHVYFQTS----------- ------- >D_melanogaster_FBpp0071971 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MTDECVTRNYGVGIRSPNGSENRGSF IMADNTDAKGCTPESLV------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VGGATAASP---L PANKFVARM----PVERYA-SEYNM--SHKHRGVALIFNHEFFD--IP--------SLKS RTGTNVDAQELKKAFENLGFAVS-VHKDCKLRDILKHVGKA-AELD--HTDNDCLAVAIL SHG-EH-------GY-LYAK-------DT-QYKLDNIWHYFTATFCPSLAGKPKLFFIQ- -ACQG-------------DRL-DGGI-----TLE-------KGVT-ET------------ ------------DGESS--------------TS-YKIPIHADFLFSYSTIP--GY----- --------------------FSWRNINNGSWYMQSLIRELNA-------NG--KKYDLLT LLTFVNQRVALD---FESNVPATPMMDRQKQIPCL-TSMLTRILRF-GDKPNGNKAG--- ------- >O_anatinus_ENSOANP00000002508 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MADDQ APTMHQKECD--FEDEV-------D-----AKPERLKVA--QLFS--KKKNEAE------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SQSGG---- PLPVRN-------RVVSSS-FIYNM--KYENLGKCIIINNKNFA--SKT-------GMST RNGTDKDAGNLQKCFRSLGFDVS-VFNDFSCNQMKEILQKA-SEEN--HENSACFACILL SHG-EG-------DC-IYGT-------DD-FIPIKELTILFRGDKCKSLLGKPKLFFIQ- -SCRG-------------TEF-DDGI-----QTD-S-----TPVT-D------------- -------------SDAN--------------PG-CRIPVEADFLFAYSTVPVKGY----- --------------------YSWRNVDRGSWFVQALCSVLHE-------HG--KELEIMQ LLTRVNHQVAIN---FESQA-SDPRYCQKKQIPCL-VSMLTKELYF-------------- ------- >M_mulatta_ENSMMUP00000037892 VEGGRRARVVTESKRNFFLGACPTPFPTEHVELGRLGGSETAMVPGKGGADYILLPFEEM DFNRNLYDIGEQLDSEELASLKFLSLDCIPQRKQEPIKDALMLFQRLQEKRMLEENNLSF LKELLFRINRLDLLTTYLNTRKEEMERELQAPGRAQISAY-------------------- ------------R---------VMLYQISEEVGRSELRSFKFLLQEEISKCKLDDDMNLL DIFVEMEKRVILGEGKL-------D-----ILKRVCAQ---VNKSLLKIINDYEEFS--- -----------------------------------------RERTRSLEGSPEEGSNG-- ------EELCGLMTISD--SPREQD----------------------------------- ---------------------------------------------------SESQ----- ----------------TLD-KVYQM--KSKPRGYCLIINNYDFT--KAREKVPKLHSIRD RNGTHLDAEALTATFEELHFEIQ-HHNDCTVEKIYKILKTY-QLMD--HSNKDCFICCIL SHG-DK-------GI-IYGT-------DGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQ- -ACQG-------------DNY-QKGI---PVETD-S-----EE-Q-PY----LEM----- ------------DLSSP--------------QT-RYIPDEADFLLGMATVN--NC----- --------------------VSYRNPAEGTWYIQSLCQSLRE-------RCP-RGDDILT ILTEVNYEVSNK--------DD--KKNMGKQMPQP-TFTLRKKLVF-PS---D------- ------- >T_rubripes_ENSTRUP00000044662 ---------------------------------------------------------CNM DFQARLLKVGNDLRKDEVRALVFLCSDILGCNP-AAVQSAGDLFSRLSDQDHLSEEQPHL LVELLGIIQRTKLL-RDHNLPRTGAQDL--------ISPYSCKS---------------- ------------R---------KLLYSLSEELTADDLKDIKFLLNNKLPRGKLEE-VTTL EVFMELEHRALISDTDL-------G-----FLESIIQP---VCPVLLEKINQFNAQNCKM HLILHIFDSYLNQIQLNTQLKALW--LIKKF-DSFLVSFSSNESWIGGSGNR---PT--- -NRCPLLTAASLLEQS-------------------------------------------- -----------------------------------------------------CSF---N TLQVGCPDV----S-VQGV-ETYLM--TAAKRGRCLIINNCNFR--VS--------RLKK REGTMVDEASLDKVLKWLGFEVE-IQRDCTSKKMSSLIQEL-AKTS--QRDWDCVMCCVL SHG-LE-------GG-VYGV-------DGGTVEIRKLMEPFSGTNCPSLAGKPKIFFIQ- -ACQG-------------SRQ-QDIV---YTDAG-T-----PGHG-YV----D-N----- ------------N-AVQ--------------AK-ECIPSHADFLLGMATVP--SF----- --------------------VSFRDGTHGTWYIQSLCQNLAD-------MVP-RGCDLIS ILTKVNADVSKK--------VAWIDSGHKTQMPQP-AFTLTKKIVF-PAPNTPHPV---- ------- >D_rerio_ENSDARP00000075650 ------------------------------------------------------------ -------------------------------------------MDKKESVDKICENKIFL LETLSVDANFILQHVQQAKL---------------------------------------- ----------------------ITLRDYNNLSDFPQRETKIINLLDKLMGKGEETCHQFI ALLRQDCV---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------L ENFPMLKDHDIFDSSVQEI-SPYRI--IKNPRGICVIINNEIFS-----------SGMMS RRGSDKDREYLAKVFHWLGFEVV-EHNNKDTAEIRNILKDL-GRTV----DGDCFVCCIL SHG-RR-------EG-VCGT-------DGNYLSIDEIRDPFTGVKCQKLVGKPKLFFIQ- -GCRG-------------ANSLQACV---KVEADAG---NSKAK---------------- ------------VEGDN--------------LD-ITIPSDTDFLIARSTTN--GH----- --------------------VSYRHVREGSWFIQSLCRNLEK-------HCP-RGADILT ILLYVNNEVSSQ-------------KSIRKQMPIY-EVALTRKLFLRPVNP--------- ------- >E_caballus_ENSECAP00000013268 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------GE---E QNMTEIDAFYK-REMFDPA-EKYKM--DHKRRGIALIFNHERFF--WHL-------TLPD RRGTSADRDNLMRRFSDLGFEVK-CFNDLKAEELLLKIYEV-STSS--HADADCFVCVFL SHG-EG-------NH-IYAY-------DA-KIEIQTLTGLFKGDKCQSLVGKPKIFIIQ- -ACRG-------------DQH-DVPV----TPLD-V-----VDHG-TDKLDANVT----- ------------QVDAA--------------SV-YTLPAGADFLMCYSVAE--GY----- --------------------YSHRETINGSWYIQDLCEMLAR-------FG--SSLEFTE LLTLVNRKVSQR---RVDFC-KDPSAIGKKQVPCF-ASMLTKKLHFFPKSK--------- ------- >X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------STKKKKTE------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------DPEKP---P QASDNV-------RIVTPA-FQYKM--NYGKVGRCIIINNKNFD--DIT-------GMSP RNGTDIDARDLLRCFKGLGFDVT-VFNNKSCTEMETLLRSV-AEQD--HKDSACFACIFL SHG-EE-------GL-IYGT-------DG-AMPIKVLTTLFRGDKCRSLVGKPKLFFIQ- -ACRG-------------CEF-DDGL-----ETD-A-----GPSN-DSL----------- ------------ETDAN--------------PR-HKIPVEADFLYAYSTVP--GY----- --------------------YSWRNPGRGSWFVQALCNVLNE-------HG--KELEVMQ ILTRVNYLVATQ---FESYC-DDPQFNKKKQIPCV-VSMLTKELYFKPC----------- ------- >A_aegypti_AAEL011562-PA ------------------------------------------------------------ --------------------------------------------MDQRDRHQIQHNMDQL IQHTNYGVLMAECVGRQMM----------------------------------------- ----------------------SEVMKAIIEDRYPDEASRHKKLFEKITKRGPHAFDILV SICQRNFPTAYKLLKNGNVSTVGSS-----SRNSSQFEF--NSTYHPNRVRSIS------ -----------------------------------AGDYSGSELLRQRLANLSIGSPSYS EEDDAKNNNDTVEETTDKGGKRRL------------------------------------ ---------------------------------------------------QEFGE---K VRSLYKVELSARPQSHRIL-EAYEM--RRRNRGVVFIVNVITYI--NE--------THPT RNGAEADKYNLVSLFQQLGFTVF-YYEDLTSDEFNNLIKEL-KQSS--YLSTECFVFYIL AHG-NH---TKGRDK-IYLN-------DNSVLYVEDVLALFNNANCPKLIRRPKLFFFS- -ICRG-------------DNP-DYGTLRLAEHTERD----------------GMI----- ------------NLKKD--------------PP-TNMPTYADMLICFSTVP--GY----- --------------------AAHRDKQYGSWFVESMCKVWAQ-------HA--HDTDVEQ LMKLVGKDSSTY---------RTEHHNALQTLGSE-QRGFFNVLYLNPGYYED------- ------- >E_caballus_ENSECAP00000004055 -----------------------------------------------------------M NFNSCLYNIGEQLDSDELASLKFLSLDHIPQRKQEPIQDALMLFQRLQEKRLLEESNLSF LKELLFRINRLDLLTTELDTSKEEMERELQSPGRAQISAY-------------------- ------------R---------VMLFQISEDVNKLELKSFKFLLSRELPKCRLDDDMILL DIFIEMEKRVMLGERNL-------D-----TLKKICEQ---VNKSLLKKINDYEELS--- -----------------------------------------REGRISLERSPDEFSNASL KCLQR-EGSLAGQAMSD--SPGQQN----------------------------------- ---------------------------------------------------SESQ----- ----------------TSD-KVYRM--ESKPRGYCLIFNNHDFS--AARRDVPKLQNIKD RNGTDLDAEALSMTFTELHFEVV-PYKNSTAKDICDALREY-QEMD--HKKKDCFICCIL SHG-DK-------GI-IYGC-------DGQEASIYELTSYFTGSNCPSLAGKPKIFFIQ- -ACQG-------------DNY-QKGI---AVETD-S-----ELTD-AY----LEM----- ------------D-SSF--------------QK-RCIPDEADFLLGMATVN--NC----- --------------------VSYRNPLEGTWYIQSLCQSLRE-------RCP-RGEDILT ILTNVNFEVSSK--------DD--KKNMGKQMPQP-TFTLRKRLVF-PL---N------- -------