10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000221740 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000024183 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000023821 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010379 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028116 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002346 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000009643 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000010831 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000005488 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000000424 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000018104 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000013840 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000020556 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000006138 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000027593 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000045524 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000012869 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000032734 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000007585 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000000197 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000013788 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000019254 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017996 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006879 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000006831 ------------------------------------------------------------------------------------------------SRMLGVCGMQKCHQEALKKNRVSL O_anatinus_ENSOANP00000000517 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000013612 --------------------------------------------------------------------------------------------------MLAACGMQRCHQEALKKNRVML M_domestica_ENSMODP00000005556 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000029853 ----------------------------------------------------------------------------------------------------GACGMQRYHQEALKKNRVML A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000017288 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000015203 ----------------------------------------------------------------------------------------------------MLGGMQKHHKDALQRLRVTL M_domestica_ENSMODP00000001598 -------------------------------------------------------------------------------------------------RMLGVWGMEQEHQEALKKNRVVL D_rerio_ENSDARP00000024255 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000014096 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000031895 -------------------------------------------------------------------------MAAPSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQETLKKNRVVL O_anatinus_ENSOANP00000005545 --------------------------------------------------------------------------------------------------------MQPCHQEALKKNRVAL B_taurus_ENSBTAP00000021099 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000022672 -------------------------------------------------------------------------MAASSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQETLKKNRVVL P_pygmaeus_ENSPPYP00000017020 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000091238 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000015596 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000016588 -------------------------------------------------------------------------------------------------RILGVCGMHPHHQETLKKNRVML D_rerio_ENSDARP00000071815 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000083664 --------------------------------------------------------------------------------------------------MLGECGMTKWERLALRRNSVKM E_caballus_ENSECAP00000003321 -------------------------------------------------------------------------MAAPSAPSLPALQQKGLMAADRGRRILGVCGMHPDHQEALKKNRVVL P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000311032 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005560 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020323 -------------------------------------------------------------------------MAAPTAGSWSTFEHKELMAADRGRRILGVCGMHPHHQETLKKNRVVL H_sapiens_ENSP00000312664 -------------------------------------------------------------------------MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVL P_troglodytes_ENSPTRP00000033921 -------------------------------------------------------------------------MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVL D_rerio_ENSDARP00000006831 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000022693 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026062 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000036247 -----------------------------------------------------------MDFHTFLYGIAEEIDSADLASLKFLCLDQIPLKKQQHIKDALVLFQTLEERGLLEEDNLFF E_caballus_ENSECAP00000019797 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000007986 --------------------------------------------------------------------------------------------------------MLSTHKEKLRTNRHTL B_taurus_ENSBTAP00000008706 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000032189 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000072390 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000038128 -----------------------------------------------------------MALTQCLYNIGEQLGSDDLAALKFLSRDHIPYRKQEPIKDALMLFQRLQEKRMLEENNLSF G_aculeatus_ENSGACP00000016983 --------------------------------------------------------------------------------------------------------MSARGKVRSQKTAIHE G_gallus_ENSGALP00000013506 -----------------------------------------LKSFKPHWISSNMEDDDSLQFRQLLLLIDEGLGAEDVAALKFLCTDLIPFRKLESVQSAMDIFQLLIDEDYLNEEDTFL A_gambiae_AGAP000830-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000010625 ------------------------------------------------------------DFRKLLFEVSEALVTEELSALKFLSLDHVPRRKLEAIHEPKAFFEVLQEKDMIGAGNLFF G_aculeatus_ENSGACP00000013740 ------------------------------------------------------------------------------------------------------CGMQERDRLALRTRSTVL M_mulatta_ENSMMUP00000015808 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000013571 ---------------------------------------------------------MSSDFRKLLFDISEALATEELAALKFLSLEHVPVRKQEDTEEPKAFFEVLKEKGMIEVEDLFF G_gallus_ENSGALP00000014503 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011951-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000003106 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000015114 ------------------------------------------------------------------------------------------------RSVTQKCGMQKRDAEALRNCSVCL C_familiaris_ENSCAFP00000016420 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000005216 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000009934 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010793 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000024166 -------------------------------------------------------------------------MAAPSAGFQYPLQPKEQMAADRGRRMLRGCGMHPDHQEALKKNRVVL G_gorilla_ENSGGOP00000007184 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000045375 --------------------------------------------------------------------------------------------------------MEERHKKILQRNRTNL G_gallus_ENSGALP00000013591 -----------------------------------------------------------MEFSQLLFVISEALDRTELASLKFLSLEHVTVRKREDIEEPKAFFQALQEKGMIEVGDLFF T_nigroviridis_ENSTNIP00000013855 --------------------------------------------------------------------------------------------------------MEERHKKILQRNRINL A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003444-PA ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000009498 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000011206 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004921-PA ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000358327 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000001629 -------------------------------------------------------------FRQILLAIDENLGKEDVDAMKFLCSDFISTKHLEGVETAQDIFQLLINRNLLSKEDTFI D_rerio_ENSDARP00000063081 -------------------------------------------------------------------------------------------------------MSKKESTQRILQHKVFL X_tropicalis_ENSXETP00000008971 -----------------------------------------------------------MDFNSMLLSIDDGLGREDIEALKFLCRDVLRKNKLLSVRSGQELFQQLMTEDLINEDNFFL T_guttata_ENSTGUP00000017449 --------------------------------------------------------------------------------------------------------MEERQRRALRRGRARL T_rubripes_ENSTRUP00000037606 ------------------------------------------------------------------------------------------------RSKMLHCGMREQDARTLRRQSAVL E_caballus_ENSECAP00000013731 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000005409 -------------------------------------------------------------------------MAAASAGRPAALQRKAPTAAGRGRRILGVCGMHPDHQEALKKNRVVL D_rerio_ENSDARP00000034228 --------------------------------------------------------------------------------------------------------MAKSIKDHLQDALSNI T_nigroviridis_ENSTNIP00000022078 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0084848 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000001627 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000040691 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011950-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000047019 --------------------------------------------------------------------------------------------------------MEQKHRQILQRHRLNL C_familiaris_ENSCAFP00000023986 --------------------------------------------------------------------------------------------------------MDEAERRALRRCRVRL T_rubripes_ENSTRUP00000031759 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000024485 ------------------------------------------------------------EFRLLLHQICEGLTGENVSMMKFLCKDAIPRSR--ELETALDFMEYFEAKGWIQEGDLGF A_gambiae_AGAP011952-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000017899 -----------------------------------------------------------MDFSKCLYNIGEQLDSDELASLKFLSLDYIPQKKQEPIKDPLMLFQRLQEKRMLEESNLFF A_gambiae_AGAP011949-PA ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022402 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000001216 --------------------------------------------------------------------------------------------------SAYQLFLSLCDQDHLSEERPHL A_gambiae_AGAP004920-PA ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003217 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010095 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000024164 -----------------------------------------------------------------------------------------------------VFLPKDMEAVRRNKTAIGT O_anatinus_ENSOANP00000006351 -----------------------------------------------------------MDFHRLLFSIGEELAADDLEALKFLCLDLIPRKKQENIQDALGLFRLLQEKGMLEEGKLFF M_musculus_ENSMUSP00000030747 --------------------------------------------------------------------------------------------------------MDEADRQLLRRCRVRL D_rerio_ENSDARP00000019984 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005791 -----------------------------------------------------------MHFQKLLFDIGKALSGEEVKALAFLCTDILG-RNLSSVESASGLFSRLRDQGFLSAEQPHL C_familiaris_ENSCAFP00000016791 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000003204 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008661 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000015102 --------------------------------------------------------------------------------------------------------MNEADRQLLRRSRLRL B_taurus_ENSBTAP00000003205 --------------------------------------------------------------------------------------------------------MNEADRLLLRRYRVRL G_aculeatus_ENSGACP00000007379 --------------------------------------------------------------------------------------------------------MEEIHKRILQRNRINL C_elegans_C48D1.2 -------------------------------------------------------------------------------------------------------MMRQDRRSLLERNIMMF A_gambiae_AGAP009832-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000093958 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000032442 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000002083 --------------------------------------------------------------------------------------------------------MEEAQRSALRRGRVRL A_gambiae_AGAP012544-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000075318 --------------------------------------------------------------------------------------------------------MADQLLENLRPDLIKG R_norvegicus_ENSRNOP00000017972 --------------------------------------------------------------------------------------------------------MEEADRQLLRRCRVRL H_sapiens_ENSP00000286186 ------------------------------------------MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFF P_pygmaeus_ENSPPYP00000014602 ------------------------------------------MKSQGQHWCSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCVGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFF P_pygmaeus_ENSPPYP00000014606 -----------------------------------------------------------MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF A_aegypti_AAEL014348-PA ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000029626 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003208 --------------------------------------------------------------------------------------------------------MEEKHKRILRRNRVHL D_melanogaster_FBpp0071971 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002508 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000037892 VEGGRRARVVTESKRNFFLGACPTPFPTEHVELGRLGGSETAMVPGKGGADYILLPFEEMDFNRNLYDIGEQLDSEELASLKFLSLDCIPQRKQEPIKDALMLFQRLQEKRMLEENNLSF T_rubripes_ENSTRUP00000044662 ---------------------------------------------------------CNMDFQARLLKVGNDLRKDEVRALVFLCSDILGCNP-AAVQSAGDLFSRLSDQDHLSEEQPHL D_rerio_ENSDARP00000075650 -------------------------------------------------------------------------------------------------------MDKKESVDKICENKIFL E_caballus_ENSECAP00000013268 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL011562-PA --------------------------------------------------------------------------------------------------------MDQRDRHQIQHNMDQL E_caballus_ENSECAP00000004055 -----------------------------------------------------------MNFNSCLYNIGEQLDSDELASLKFLSLDHIPQRKQEPIQDALMLFQRLQEKRLLEESNLSF 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000221740 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000024183 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000023821 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010379 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028116 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002346 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000009643 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000010831 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000005488 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000000424 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000018104 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000013840 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000020556 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000006138 -----------------ELAEEGGLGSGLPWGAGWLPGAAGCPWGPCGLCPSGL-APSGLLRQPQQLVQELSRCGALRGCPKVFLLLSSAPGAAPEPGAFLTSLGELCGRCPHWSLLQLL M_mulatta_ENSMMUP00000027593 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000045524 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000012869 -----------------------------------------------------------------------MEGSLGSGRRSGSDGQPAPPKISPTTEELQSRLQETLDLLSSQELRSFR M_domestica_ENSMODP00000032734 -------------------------------------------------------------------------------------------MLQPDMESFKAQVVSTLTKLSPEELRRFG C_familiaris_ENSCAFP00000007585 -----------------------------------------------------------------------MERSPGSGGRWECSGPPAPPELTPDVAELQSRVQETLELLSPQDLRNFR O_cuniculus_ENSOCUP00000000197 -----------------ELGEEGGLGPGLPPGASFVQEAAGCPPEPRGLCPCGPGAPRGQLRQPRQLVQELSCCEALQGCPKVVLLLSSGAGAALEPGAFLAGLRELCGRRPHWSLLQLL A_carolinensis_ENSACAP00000013788 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000019254 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017996 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006879 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000006831 AKQLVLKELMEHLIEKDV----------------------------------------------------------------ITEEMMEMIQAKAGNFSQNIEFLNLLPKRGPKAFSAFC O_anatinus_ENSOANP00000000517 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000013612 AKQLVLNVLVEHMVEKDI----------------------------------------------------------------IPTEMVEMIQAKSGSFDRNVEFLNLLPKRGPNAFSAFC M_domestica_ENSMODP00000005556 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000029853 ARELVLKELMEHMIEKDI----------------------------------------------------------------ITIEMVEMIQAKSGSFSQNVEFLNLLPKRGPNAFSAFC A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000017288 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000015203 LHDMIIEELVEHLVSSGI----------------------------------------------------------------LTPIMHSTIMAHRSEYKQNVTLLTQLPKRGPRAFSEFC M_domestica_ENSMODP00000001598 AKQLLLSELLEHLLEKDI----------------------------------------------------------------ITLEMRELIQAKVGSFSQNVEFLNLLPKRGPHAFEAFC D_rerio_ENSDARP00000024255 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000014096 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000031895 AKQLLLSELLEHLLEKDI----------------------------------------------------------------ITLEMRELIQAKGGSFSQNVELLNLLPKRGPQAFDAFC O_anatinus_ENSOANP00000005545 AKQLMLSELLEHLLEKDV----------------------------------------------------------------ITMEMRELIQAKAGSFSQNVEFLNLLPKRGPKAFDAFC B_taurus_ENSBTAP00000021099 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000022672 AKQLLLSELLEHLLEKDI----------------------------------------------------------------ITLEMRELIQAKGGSFSQNVELLNLLPKRGPQAFDAFC P_pygmaeus_ENSPPYP00000017020 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000091238 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000015596 ---------------------------------------------------------------------------------------------AGTRRDQARQLVTDLETRGRRALSVFI M_mulatta_ENSMMUP00000016588 AKQLLLSELLEHLLEKDI----------------------------------------------------------------ITLEMRELIQAKVGSFSQNVELLNLLPKR-PQAFDAFC D_rerio_ENSDARP00000071815 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000083664 LQDLVVDDLLIQCLQQDGI---------------------------------------------------------------LTDSMAESIMAKPTSQGRSHQLLFLLPKRGPRAFSTFC E_caballus_ENSECAP00000003321 AKQLLLSELLEHLLEKDI----------------------------------------------------------------ITLEMRELIQAKVTSFGQNVELLNLLPKRGPQAFEAFC P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000311032 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005560 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020323 AKQLLLSELLEHLLEKDI----------------------------------------------------------------ITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFC H_sapiens_ENSP00000312664 AKQLLLSELLEHLLEKDI----------------------------------------------------------------ITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFC P_troglodytes_ENSPTRP00000033921 AKQLLLSELLEHLLEKDI----------------------------------------------------------------ITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFC D_rerio_ENSDARP00000006831 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000022693 -------------------------------------------------------------------------------------------------------------------MTDDQ M_musculus_ENSMUSP00000026062 -------------------------------------------------------------------------------------------------------------------MTDDQ M_domestica_ENSMODP00000036247 LKELLFRINRIDLLNEPLNTKGPEMERELQVPNKARISPYRLHLHTTIWPFRDNWTCRITLSVSFTS-----RTKQLLSVMVILLFNLSEGVGPSELKSIKFMLSSKIPKCKIEDDMTLM E_caballus_ENSECAP00000019797 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000007986 CKELVVDELLQELIGEG-I---------------------------------------------------------------FNDILADRVLSHQRDFKKNVEFLTLLPGRGPNAFNAFR B_taurus_ENSBTAP00000008706 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000032189 -----------------------------------------------------------------------------------------------------MGEQRNTSSKELAAAEATG D_rerio_ENSDARP00000072390 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000038128 LKELLFRVNRLDLLLNYLYTSEEEMKRELQIPGRAQISAY--------------------------------R---------ILLFQISEDVNKVELKDFKFFLSQEIAKCKLDDDMTLL G_aculeatus_ENSGACP00000016983 ALCADYSLILNKVFEKGLIT--------------------------------------------------------------PREYRNLKSINKESVEGHVIELVDKLLDKGEDTCEAFL G_gallus_ENSGALP00000013506 LAELLYRIKYHSLL-SKLGYTKEKVQECL--HEKGKVSPYR-----------------------------------------QMLYELSENITNDMLQEIVFLLRNHLPKRR--RTISAL A_gambiae_AGAP000830-PA -------------------------------------------------------------------------------------------MSMPDVVDIRNEINKEHVRESLDRNGDEQ T_guttata_ENSTGUP00000010625 LKELLYRIHRIDLLSTPLGCSREEMERELQLPGRAQVSAY--------------------------------R---------QLLYGIAEDLTSEDVRSVKFLLQKQLPKNKLQENASML G_aculeatus_ENSGACP00000013740 CKQLVVDELLIQSLQTDEI---------------------------------------------------------------LTEAMAENIMAEQTSQKRSWRLLLLLPKRGPRAFSSFC M_mulatta_ENSMMUP00000015808 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000013571 LKELLYRINRIDLLASHLGSSREEMERELQVPGKAKVSAYR-----------------------------------------QLLYGIAEDLTPDDVRSIKFLLQEKLPKNKLQDNASML G_gallus_ENSGALP00000014503 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011951-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000003106 ----------------------------------------------------------------------------------MDCVGWPPGRRWHLEKNTSCSGSSGICASYVTQMADDQ O_latipes_ENSORLP00000015114 LKDLVVDELLIQALVKDGI---------------------------------------------------------------LTQNMAESIMVQKTSHHRSFKLLLLLPKRGPRAFKSFC C_familiaris_ENSCAFP00000016420 -------------------------------------------------------------------------------------------------------------------MADDQ P_troglodytes_ENSPTRP00000005216 ----------------------------------------------------------------------------------MDCVGWPPGRKWHLEKNTSCGGSSGICASYVTQMADDQ T_nigroviridis_ENSTNIP00000009934 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010793 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000024166 AKELLLSELLEHLLEKDI----------------------------------------------------------------ITLEMREHIQAKTGSFGQNVELLNLLPKRGPQAFDAFC G_gorilla_ENSGGOP00000007184 -------------------------------------------------------------------------------------------------------------------MADDQ T_rubripes_ENSTRUP00000045375 VGELDPSSLYDGLIEKRVFT--------------------------------------------------------------HDMIDEIKS--SGTRRDQARQLIRDLETRGSRAFPLFL G_gallus_ENSGALP00000013591 LKELLYRINRIDLLASYLGSSREEMERELQVPGRARVSPF--------------------------------R---------YLLFQLSENITKDDMKCFKFLLGKELPKCKLSPETTMP T_nigroviridis_ENSTNIP00000013855 VSELEPLNLYDGLIEKGVFT--------------------------------------------------------------HDMIDEIKC--SGARRDQARQLVRDLETRGSRAFPAFL A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003444-PA -----------------------------------------------------------------------------------------------------------------------M O_cuniculus_ENSOCUP00000009498 -------------------------------------------------------------------------------------------------------------------MADDQ T_guttata_ENSTGUP00000011206 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004921-PA ---------------------------------------------------------------------------------------------------RSCNLMDDLPPEPTPDNEFYD H_sapiens_ENSP00000358327 ----------------------------------------------------------------------------------MDCVGWPPGRKWHLEKNTSCGGSSGICASYVTQMADDQ A_carolinensis_ENSACAP00000001629 VAELLYRIKCHFLL-QKIGYTQQKVEHNL--FHIRNVSEYR-----------------------------------------QMLYEISEGFTEENVKTAMFLLREHLPKKQ----SIAV D_rerio_ENSDARP00000063081 IDTLSVEASFILQNVQQAKL--------------------------------------------------------------ITQRDYNNLSDVSERETKIIKLLDKLIGRGEETCQEFI X_tropicalis_ENSXETP00000008971 LKELLYIINHHSLL-RNLGTNKEKVQKAL--PRQGRISPYR-----------------------------------------QMLYQLSENIAGDDEKRVYFLLPL---QKKHKENKTFL T_guttata_ENSTGUP00000017449 VAALRVEPLWEPLEQRGLFT--------------------------------------------------------------RPMLEELQS--AGSRGEQARQLIIDLETRGKQAFPAFL T_rubripes_ENSTRUP00000037606 CKQLVVDELLIQCLQADDI---------------------------------------------------------------LTESMAESIMAEQTSQKRSWRLQLLLPKRGPKAFSSFC E_caballus_ENSECAP00000013731 -------------------------------------------------------------------------------------------------------------------MADDQ C_familiaris_ENSCAFP00000005409 AKQLLLSELLEHLLEKDI----------------------------------------------------------------ITLEMREHIQAKVGGFSQNVELLNLLPKRGPQAFDAFC D_rerio_ENSDARP00000034228 GADNLRRFQSRLGD--------------------------------------------------------------------RKQEPRVRKSTIEKLKDEIDLVDLLVNTFTSDAVSVTV T_nigroviridis_ENSTNIP00000022078 ----------------------------------------------------------------------------------------------------------------MAGEAAGI D_melanogaster_FBpp0084848 ---------------------------------------------------------------------------------------------MDATNNGESADQVGIRVGNPEQPNDHT M_mulatta_ENSMMUP00000001627 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000040691 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011950-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000047019 VKALNPEDVCDKLLSKGVFT--------------------------------------------------------------QDMIDEIQS--KATRRDQARQLVKDLETRGSLAFPAFL C_familiaris_ENSCAFP00000023986 VRELQVAALWDALLSRELFT--------------------------------------------------------------AAMVEDLQHAGSGSRSDQARQLVIDLETRGSQALPLFI T_rubripes_ENSTRUP00000031759 -------------------------------------------------------------------------------------------------------------SMQMAGEPTEI C_intestinalis_ENSCINP00000024485 LAEVLYRINRHDLLKLLPGVKNRRDYEENFQAQQNNFTTYR-----------------------------------------VVCFMLADELTEGDLKILKRLCAGKMSKANVRRSVDVL A_gambiae_AGAP011952-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000017899 LKELLFRINRLDLLMTYLDTSKEDMQQELQIPGRAQISAY--------------------------------R---------VMLFQISEDVSKLELKSFKFLLSREISRCKLDDDLNLL A_gambiae_AGAP011949-PA ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022402 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000001216 LSELLSIIQRTRLL-RDLDLRSSATSNL--------ISAY--------------------------------R---------KLLYSLSEDLTDDNLKEIKFLLTETLPRRKLEDNVTTL A_gambiae_AGAP004920-PA ------------------------------------------------------------------------------------------------------VCGRDILHCKTMNTSTLS X_tropicalis_ENSXETP00000003217 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010095 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000024164 IFCADYGLILNKVDEKKLIT--------------------------------------------------------------RRDYNNLKNINGEDIWGHVIALVDKIMNKGDATCEAFL O_anatinus_ENSOANP00000006351 LKELLFRIHRIDLLTSHLRTSQEDVARELEEPGRAQVSAYS-------------------------------R---------VLLFTLSDNVTREELKSITFFLSNDLPRSRLDNKQTLM M_musculus_ENSMUSP00000030747 VSELQVAELWDALLSRELFT--------------------------------------------------------------RDMIEDIQQAGSGSRRDQARQLVTDLETRGRQALPLFI D_rerio_ENSDARP00000019984 -------------------------------------------------------------------------MDKEALTSENEVSGDDQENYGKGDVTDAKPDPKAMCRVDKE-ALTSE G_aculeatus_ENSGACP00000005791 LTELLIIIQRVRLT-RDVDLPAEP---------SSLISPY--------------------------------R---------KMLYNLSEELTADDLKDMKFLLHSYLPRRKLEENVSTL C_familiaris_ENSCAFP00000016791 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000003204 ----------------------------------------------------------------------------------------------MSLKSAADVLMSGVPTPHTNENNNVG G_aculeatus_ENSGACP00000008661 -------------------------------------------------------------------------------------------------------------QVNGA-RLTSA E_caballus_ENSECAP00000015102 VRELQVDSLWDALLTRELFT--------------------------------------------------------------PDMIEDIQR--SGSRRDQARQLIIDLETRGSQALLLFI B_taurus_ENSBTAP00000003205 VGELQVASLWDALLSRELFT--------------------------------------------------------------PDMIEDIQRAGSGSRRDQARQLILDLETRGSQALPLFI G_aculeatus_ENSGACP00000007379 VRDLDPSSLYDGLLEKGVFT--------------------------------------------------------------QDMIDEIKS--AGTRRDQARKLVQDLETRGSRAFAMLL C_elegans_C48D1.2 SSHLKVDEILEVLIAKQV----------------------------------------------------------------LNSDNGDMINSCGTVREKRREIVKAVQRRGDVAFDAFY A_gambiae_AGAP009832-PA -----------------------------------------------------------------------------------------------------------QPLTKAFSAMFSR D_rerio_ENSDARP00000093958 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000032442 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000002083 VEGLRPEVLWGPLQARGVFT--------------------------------------------------------------SAMVEDMQS--TGTRREQARQLVIDLETRGKQAFPIFL A_gambiae_AGAP012544-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000075318 LSERVINGLLDDLQQKKVF---------------------------------------------------------------GEEEIEDIQHRMKTRADQARHVIDDVKRKGVKASEIML R_norvegicus_ENSRNOP00000017972 VRELQVAELWDALLSRELFT--------------------------------------------------------------RDMIEDIQRAGSGSRRDQARQLVIDLETRGRQALPRFI H_sapiens_ENSP00000286186 LAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFR-----------------------------------------NLLYELSEGIDSENLKDMIFLLKDSLPKTE----MTSL P_pygmaeus_ENSPPYP00000014602 LAELLYIIRQKKLL-QHLSYTKEEVEGLL--PTRQRVSLFR-----------------------------------------NLLYELSEGIDSENLKDMIFLLKDSLPKTE----MTSL P_pygmaeus_ENSPPYP00000014606 LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQSVPFWWRVDHILIR---------VMLYQISEEVSRSELRCFKFLLQEEISKCKLDDDMNLL A_aegypti_AAEL014348-PA ----------------------------------------------------------------------------------------------------------------MKKIMFGR M_musculus_ENSMUSP00000029626 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003208 VKELDLSDLCDVLLRKDVFT--------------------------------------------------------------QSMINDIKRQNCETKRDQARKLVKDLETRGNEAFSAFL D_melanogaster_FBpp0071971 ----------------------------------------------------------------------------------------------MTDECVTRNYGVGIRSPNGSENRGSF O_anatinus_ENSOANP00000002508 -------------------------------------------------------------------------------------------------------------------MADDQ M_mulatta_ENSMMUP00000037892 LKELLFRINRLDLLTTYLNTRKEEMERELQAPGRAQISAY--------------------------------R---------VMLYQISEEVGRSELRSFKFLLQEEISKCKLDDDMNLL T_rubripes_ENSTRUP00000044662 LVELLGIIQRTKLL-RDHNLPRTGAQDL--------ISPYSCKS----------------------------R---------KLLYSLSEELTADDLKDIKFLLNNKLPRGKLEE-VTTL D_rerio_ENSDARP00000075650 LETLSVDANFILQHVQQAKL--------------------------------------------------------------ITLRDYNNLSDFPQRETKIINLLDKLMGKGEETCHQFI E_caballus_ENSECAP00000013268 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL011562-PA IQHTNYGVLMAECVGRQMM---------------------------------------------------------------SEVMKAIIEDRYPDEASRHKKLFEKITKRGPHAFDILV E_caballus_ENSECAP00000004055 LKELLFRINRLDLLTTELDTSKEEMERELQSPGRAQISAY--------------------------------R---------VMLFQISEDVNKLELKSFKFLLSRELPKCRLDDDMILL 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000221740 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000024183 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000023821 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010379 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028116 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002346 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000009643 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000010831 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000005488 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000000424 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000018104 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000013840 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000020556 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000006138 TEVFCRIAEEFSGATYCPVLRSSLR----------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000027593 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000045524 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000012869 DHLKKV--EPPVSQVKLELEGHSPSGLAKLLAKHYYPAAVAKRVLVQVLELLPR------------------------------------------------------------------ M_domestica_ENSMODP00000032734 IYLRNVGEEPRVSRHDLEM-ATKPEELADLLLKRYVMTG-TPRVLVQVLGQVPR------------------------------------------------------------------ C_familiaris_ENSCAFP00000007585 LLLKTVDEEPRVSPVKLELEGRKKAGLARLVAQNYCEPA-ASRVLVKVLRQLRR------------------------------------------------------------------ O_cuniculus_ENSOCUP00000000197 TELFCRVAEDSAGDIRCPVFQSSLR----------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000013788 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000019254 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017996 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006879 --MTDIGDGAHLGKDLA-------D-----TKS--------------IPGFK-------------------------------------------------------------------- A_carolinensis_ENSACAP00000006831 EALRETKQPHLEEMLLL-------N-----LIDFLLFH---------------------------------------------------------------HVIVPPQNAHLPLH----- O_anatinus_ENSOANP00000000517 ---------AASGEVMV-------D-----SKS--------------FHSSQGY------------------------------------------------------------------ T_guttata_ENSTGUP00000013612 EALRETQQQHLETLILK-------T-----MSS--LSQ-------------------------------------------------------------EIARLEHCHESDLPYP----- M_domestica_ENSMODP00000005556 ---------MEDTGTTV-------D-----AKS--------------TKNSG-------------------------------------------------------------------- G_gallus_ENSGALP00000029853 EALQETKQQHLAEMILK-------T-----ESS--LRH-------------------------------------------------------------GIATLEQRYGSNLPLP----- A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000017288 -MMTDIKDGPRSGEDVS-------D-----ARS--------------FPGSK-------------------------------------------------------------------- X_tropicalis_ENSXETP00000015203 NALHATGQRHLAEQLEE-------E-----AQQQQME----------------------------------------------------------------SVTPEVHERSFPLP----- M_domestica_ENSMODP00000001598 DALRETKQGHLEDLLHR-------T-----LYS--FQN-------------------------------------------------------------LRPPLGCDYDSSFPLP----- D_rerio_ENSDARP00000024255 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000014096 ---------MDNNETSV-------D-----SKS--------------INNFE-------------------------------------------------------------------- G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000031895 EALRETRQGHLEDLLLT-------T-----LSD--IQH-------------------------------------------------------------VLPPLSCDYDTSLPFS----- O_anatinus_ENSOANP00000005545 AALRETKQGHLQDLLYR-------T-----LSN--LSPPSTAVGALGTQGEE-----------------------------------------------LAGRLGGRWRGLPSLP----- B_taurus_ENSBTAP00000021099 ---------MENTENSV-------D-----SKS--------------IKTSE-------------------------------------------------------------------- R_norvegicus_ENSRNOP00000022672 EALRETRQGHLEDLLLT-------T-----LSD--IQH-------------------------------------------------------------ILPPLSCDYDSSLPFS----- P_pygmaeus_ENSPPYP00000017020 ---------MENTENSV-------D-----SKS--------------IKNLE-------------------------------------------------------------------- M_musculus_ENSMUSP00000091238 ---------MENNKTSV-------D-----SKS--------------INNFE-------------------------------------------------------------------- O_anatinus_ENSOANP00000015596 SCLRETDQHALAALLSE-------G-----CQAPQVTPV--DIRPVE----IIR--------------------------------------PGGQGDVCKYSKIHPKCYSPPLPFQSTS M_mulatta_ENSMMUP00000016588 EALRETKQGHLEDIELK-------L-----RVS--ALM-------------------------------------------------------------KPTGLGSDYNDILGLM----- D_rerio_ENSDARP00000071815 -----MSDVKPKGVDTV-------D-----ARQ--------------SDAKESS------------------------------------------------------------------ D_rerio_ENSDARP00000083664 SALKETEQHHLCKLLMD-------F-----TEKDKKN---------------SQ---------------------------------------------YKLSPEICKKKNKHTH----- E_caballus_ENSECAP00000003321 VALRETKQGHLEDLLLT-------T-----LSG--LQH-------------------------------------------------------------VLPPLSCDYDLSLPFP----- P_troglodytes_ENSPTRP00000054330 ---------MENTENSV-------D-----SKS--------------IKNLE-------------------------------------------------------------------- H_sapiens_ENSP00000311032 ---------MENTENSV-------D-----SKS--------------IKNLE-------------------------------------------------------------------- M_domestica_ENSMODP00000005560 ---------MEDTGTTV-------D-----AKS--------------IKNSG-------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000020323 EALRETKQGHLEDMLLT-------T-----LSG--LQH-------------------------------------------------------------VLPPLSCDYDLSLPFP----- H_sapiens_ENSP00000312664 EALRETKQGHLEDMLLT-------T-----LSG--LQH-------------------------------------------------------------VLPPLSCDYDLSLPFP----- P_troglodytes_ENSPTRP00000033921 EALRETKQGHLEDMLLT-------T-----LSG--LQH-------------------------------------------------------------VLPPLSCDYDLSLPFP----- D_rerio_ENSDARP00000006831 -----------MNGDCV-------D-----AKR------------VDTTDASKD------------------------------------------------------------------ R_norvegicus_ENSRNOP00000022693 DCAAELEMADSSTEDGV-------D-----AKPDRSTII--SSLLW-KKKKNAS------------------------------------------------------------------ M_musculus_ENSMUSP00000026062 DCAAELEKVDSSSEDGV-------D-----AKPDRSSII--SSILL-KKKRNAS------------------------------------------------------------------ M_domestica_ENSMODP00000036247 DLFIEMEKRGILGEGNL-------D-----ALKIVCDQ---IDKSLLKKIQEYE------------------------------------------------------------ISKG-- E_caballus_ENSECAP00000019797 ---------MENSKISV-------D-----SKS--------------IKNSE-------------------------------------------------------------------- G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000007986 IALINSDQSHLAELLDP-------A-----QGVSQPNES--NANDGSGGPELSA---------------------------------------------SIFRFESIATANSNLPGTSGT B_taurus_ENSBTAP00000008706 ---------------------------------------------S-KKKKNDS------------------------------------------------------------------ C_familiaris_ENSCAFP00000032189 QSGKELEVSMENTENSV-------D-----AKS--------------FKNAE-------------------------------------------------------------------- D_rerio_ENSDARP00000072390 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000038128 DIFVEMEKRTILGEENL-------D-----TLKRICEQ---VNKSLLKKIYDYEELR--------------------------------------------KERRMSLERDPYAFSNDMS G_aculeatus_ENSGACP00000016983 SLLQTDDDIVKTYPALRTLQLDDRG----------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000013506 ELLILLEKQCLLTENNV-------Q-----ILEEVFRN---VSPDLLETVKCYRMAK-------------------VALPHQGNTLPIKESSPSYTVHVRLFNSPQGGSFILVLNESYCE A_gambiae_AGAP000830-PA QLVQDVNDALGTRKGHD------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000010625 QVFLEMEIKGIIKEDNM-------T-----TLKDILQR---FRADIKKKIDAYEEKK--------------------------------------------KGLTGSAEVSLELPVSWI- G_aculeatus_ENSGACP00000013740 SALQETEQQHLYELLIQ-------S-----SEKDGKETP------------------------------------------------------------GMLMCGQFIDSSLPLP----- M_mulatta_ENSMMUP00000015808 ---------MENTENSV-------D-----SKS--------------IKSLE-------------------------------------------------------------------- G_gallus_ENSGALP00000013571 KVLVEMERNGIIKEDDL-------T-----MLKSILKA---FRADLKKKIDNYEEKT-----------------------------------------------KGWPWKSSCFPNKTQA G_gallus_ENSGALP00000014503 ------------------------------------------------KKKNGE------------------------------------------------------------------ A_gambiae_AGAP011951-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000003106 GCVEEQGLGDSANEDSV-------D-----AKPDRSSFV--PFLFS-MKKKNVS------------------------------------------------------------------ O_latipes_ENSORLP00000015114 SALKETEQEHLCDLLTQEEEGREVC-----LDTPLIN----------------------------------------------------------------SEEQSEVSSSMSYP----- C_familiaris_ENSCAFP00000016420 DCGMEQAAGDSESPDAV-------D-----ARPDRSSFV--PSLFS-RKKKNDS------------------------------------------------------------------ P_troglodytes_ENSPTRP00000005216 GCIEEQGVEDSANEDSV-------D-----AKPDRSSFV--PSLFS-KKKKNVT------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000009934 ----MSANGPASGEDFT-------D-----ASK---------------GGEQPS------------------------------------------------------------------ G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010793 -MDMAETAEELSGKDQV-------D-----TKP--------------VISKRSP------------------------------------------------------------------ B_taurus_ENSBTAP00000024166 VALRETKQSHLEELLLR-------T-----LSG--LQP-------------------------------------------------------------VVPPLSCDYDLSLPFP----- G_gorilla_ENSGGOP00000007184 GCVXXXXXXXXXXXXXX-------X-----XXXXXXXXX--XXXXX-XXXXXXX------------------------------------------------------------------ T_rubripes_ENSTRUP00000045375 ECLQETGHHTLVELLQD-------G-----GPAVQIQP-PTPVPIDRPVIQPLP---------------------------------------------VCKSAIRSRVLRGTMTVKAAP G_gallus_ENSGALP00000013591 DVFIEMEKKGILKEDNL-------T-----VLKTICGK---VDKSLLKKIEDYE-------------------------------------------------LNLLGEGEMLVTEGQRS T_nigroviridis_ENSTNIP00000013855 ECLKETGYHSLAELLQN-------G-----APTVQIQP-PTPIPVDRPVIQPLP--------------------------------------------------ISPPLVPPE------- A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003444-PA DTTDELDVLGFGSRTNE------------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000009498 AHAGELGAGDSESADAV-------D-----AKPDRSSFV--PALFS-KKKKNGP------------------------------------------------------------------ T_guttata_ENSTGUP00000011206 ------------------------------------------------KKKNGE------------------------------------------------------------------ A_gambiae_AGAP004921-PA GNIPSITQTD-------------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000358327 GCIEEQGVEDSANEDSV-------D-----AKPDRSSFV--PSLFS-KKKKNVT------------------------------------------------------------------ A_carolinensis_ENSACAP00000001629 KLLTSLEKQDLLAEDKL-------A-----ILEKICNK---VSPELRNKVDKFKERS------------------------------VFKAFVFSLCYENLYPSNFLAVFLLILQAS--- D_rerio_ENSDARP00000063081 DLLRQDCV---------------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000008971 EVLCQLERENSITEDDV-------E-----LLEDIFKK---VAPDLLKIIEKYKERG---------------------DKLHQTENHLIDPSAPPEDEHELINPPLSIQVSSKDSELWDK T_guttata_ENSTGUP00000017449 SILRDTGQGHLAEMLMQ-------E-----CESRPVPPQLPDLRPVE------------------------------------------------------------------------- T_rubripes_ENSTRUP00000037606 SALRATDQQHLCDLLTQ-------T-----FETNGNG----------------------------------------------------------------THVETCVDSSVPLP----- E_caballus_ENSECAP00000013731 DCVVEQGAGDSTSTDAV-------D-----AKPDRSSFV--PSLFS-KKKKNGP------------------------------------------------------------------ C_familiaris_ENSCAFP00000005409 VALRETKQGHLEDLLLT-------T-----LSG--LQH-------------------------------------------------------------GLPPLSCDYDLSLTFP----- D_rerio_ENSDARP00000034228 DILRGIKCNAVAEELLE-------------------------------------------------------------------------------NTGQVYSIFKLCKKNSHYTKPPII T_nigroviridis_ENSTNIP00000022078 PELGGEAEGEHRCEDDV-------D-----AKPDRRGRF--LLFKS-KKKNDGQ------------------------------------------------------------------ D_melanogaster_FBpp0084848 DALGSVGSGGAGSSGLV------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000001627 ---------------------------------------------S-KKKKNVS------------------------------------------------------------------ T_rubripes_ENSTRUP00000040691 --TNMSANGPSPGGDFT-------D-----AKK--------------GAGQQPR------------------------------------------------------------------ A_gambiae_AGAP011950-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000047019 DSLRETGHNDLAELLQS-------GDGVHRPPVISVQPSPIPLPVQNLN-------------------------------------------------------HTEKPDKPDIASPRLV C_familiaris_ENSCAFP00000023986 SCLEDTGQDALASCLTM-------S-----RQAVKQNPE--ATRPLD-LMPVVL--------------------------------------GPTRLTPEDLR--GKDPSKLTPGKLAPV T_rubripes_ENSTRUP00000031759 SDLGGEVEEGGQSEDDV-------D-----AKPDRKGRF--LLFKS-KKNKDGQ------------------------------------------------------------------ C_intestinalis_ENSCINP00000024485 SWLTCMEEEDLLSEGDL-------D-----FIMSILQHL--DNQKPYKLFQRVR---------------------------------------------------------MNDNTVTLP A_gambiae_AGAP011952-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000017899 DIFIEMEKRVILGERNL-------D-----TLKRICDQ---INKSLLKKITDYEELN--------------------------------------------REQTMNLQRSLDEISNDMS A_gambiae_AGAP011949-PA ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022402 ------MSVNGPGEDRT-------D-----AKT----------------EQSEV------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000001216 EVFLELECMDLLSKTNL-------G-----LLKSILQP---VCPVLAERIRQFEAQN-------------------SCQPAADWGFAVKKITDPLQVQ--------GGSDAL---PSLPE A_gambiae_AGAP004920-PA TAFDEVDNNTRVLSLVASVP---------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000003217 --MEESHNGVQYGEDTA-------D-----AKT--------------YFTNQQI------------------------------------------------------------------ O_latipes_ENSORLP00000010095 ------MASNRPGEDST-------D-----ARK--------------DNGELAA------------------------------------------------------------------ T_rubripes_ENSTRUP00000024164 NLLQTDDDIKSTYPELKDTHFNIFF----------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000006351 GIFIEMEKKGILGESNL-------D-----MLKKICDK---IDKTLLGKIDHYEERR--------------------------------------------ADCTLHSSEHLTVLDRDMY M_musculus_ENSMUSP00000030747 SCLEDTGQGTLASLLQS-------G-----RQAAKQDPE--AVKPLDHLVPVVL--------------------------------------GPMGLTAKEQRVVKLDPSQPAVGNLTPV D_rerio_ENSDARP00000019984 IEVLEEDQDSYGEEDVT-------D-----AKPDRKGRF--RLFGN-FKKNDGK------------------------------------------------------------------ G_aculeatus_ENSGACP00000005791 EIWLEMEHKDLMNEHNL-------H-----LLEILISK---VCPMLKDKINQLKAQQ--------------------------------------ETPTSPATQESGRQGSLSAPNAPNQ C_familiaris_ENSCAFP00000016791 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000003204 QSEVD------------------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000008661 QDVA--AEEGGPTGDQT-------D-----AKPDRRGRF--LLFGNIKKNKDGQ------------------------------------------------------------------ E_caballus_ENSECAP00000015102 SCLEDTGQDTLASFLRT-------S-----SQAAKQNPE--AIRPSD-LPPVVL--------------------------------------GPVGLKPEELTAVKQDPSKLTPGKLTPV B_taurus_ENSBTAP00000003205 SCLEDTGQDTLASLLKT-------S-----RQAAKQ-------------------------------------------------------------------------SKPSQGKLAPV G_aculeatus_ENSGACP00000007379 LCLEETDQHGLAELLQR-------A-----APAVQIWP----AAPNQPFVLMLN--------------------------------------------------SREKTTSPSIQYRNPV C_elegans_C48D1.2 DALRSTGHEGLAEVLEPLARSVDSN-----AVEFECPMS--PASHRRSRALSPA-----------------------------------GYTSPTRVHRDSVSSVSSFTSYQDIYSRARS A_gambiae_AGAP009832-PA KQEDSSDTRGMPHGSPI------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000093958 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000032442 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000002083 SILRDTGHGDLADMLDE-------G-----CGSPMSPPV--DLRPVQ------------------------------------------------------------------------- A_gambiae_AGAP012544-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000075318 ASLKTRDPHLYDTLGIE------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000017972 SCLEDTGQGSLASFLQS-------S-----GQAAKQDPE--AVTPLDHLVPVVL--------------------------------------GPMGLKSKEQKVVKLDPSQPALGNLTPV H_sapiens_ENSP00000286186 SFLAFLEKQGKIDEDNL-------T-----CLEDLCKT---VVPKLLRNIEKYKREK----------------------AIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQ---E P_pygmaeus_ENSPPYP00000014602 SFPAFLEKQGKIDEDNL-------T-----CLEDL-KT---VVPKLLRNIEKYKREK----------------------AVQIVTPPIDKEAESYQGEEELVSQTDVKTFLEALPQE--E P_pygmaeus_ENSPPYP00000014606 DIFIEMEKRVILGKGKL-------D-----ILKRVCAQ---INKSLLKIINDYEEFS--------------------------------------------RG----------------- A_aegypti_AAEL014348-PA KEVNSPQ----------------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000029626 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003208 EGLRVTGQQNLLELLQK-------S-----APRVHFQP-GKSTEAGYLLIQPHP----------------------------------------VYIEDAVPKKPRTQPSPRKRERRGGG D_melanogaster_FBpp0071971 IMADNTDAKGCTPESLV------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000002508 APTMHQKECD--FEDEV-------D-----AKPERLKVA--QLFS--KKKNEAE------------------------------------------------------------------ M_mulatta_ENSMMUP00000037892 DIFVEMEKRVILGEGKL-------D-----ILKRVCAQ---VNKSLLKIINDYEEFS--------------------------------------------RERTRSLEGSPEEGSNG-- T_rubripes_ENSTRUP00000044662 EVFMELEHRALISDTDL-------G-----FLESIIQP---VCPVLLEKINQFNAQNCKMHLILHIFDSYLNQIQLNTQLKALW--LIKKF-DSFLVSFSSNESWIGGSGNR---PT--- D_rerio_ENSDARP00000075650 ALLRQDCV---------------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000013268 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035938 ----------------------------------------------STKKKKTE------------------------------------------------------------------ A_aegypti_AAEL011562-PA SICQRNFPTAYKLLKNGNVSTVGSS-----SRNSSQFEF--NSTYHPNRVRSIS-----------------------------------------AGDYSGSELLRQRLANLSIGSPSYS E_caballus_ENSECAP00000004055 DIFIEMEKRVMLGERNL-------D-----TLKKICEQ---VNKSLLKKINDYEELS--------------------------------------------REGRISLERSPDEFSNASL 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000221740 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000024183 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000023821 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010379 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028116 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002346 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000009643 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000010831 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000005488 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000000424 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000018104 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000013840 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000020556 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000006138 -----------------------------------------------------------------------------------------------------------------------G M_mulatta_ENSMMUP00000027593 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000045524 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000012869 ------------------------------------------------------------------------------------------------------ADLLPRWQ-SAPTD---C M_domestica_ENSMODP00000032734 ----------------------------------------------------------------------------------------------------KDLALEWALRRRSPSR---C C_familiaris_ENSCAFP00000007585 ------------------------------------------------------------------------------------------------------ADLLRLWQGAADRG---G O_cuniculus_ENSOCUP00000000197 -----------------------------------------------------------------------------------------------------------------------G A_carolinensis_ENSACAP00000013788 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000019254 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017996 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006879 ---------------------------------------------------------------------------------------------------------------GKNLP---A A_carolinensis_ENSACAP00000006831 -----------TVCDLL--------------PFAYQLFISSAEPMEH-------------------------------------------------------------SLDDGDGP---H O_anatinus_ENSOANP00000000517 --------------------------------------------------------------------------------------------------------------SSRKVP---G T_guttata_ENSTGUP00000013612 ---------ASESCNSK--------------RPRWL------EPMEH-------------------------------------------------------------SLDNRDGP---S M_domestica_ENSMODP00000005556 ---------------------------------------------------------------------------------------------------------------VKLFH---G G_gallus_ENSGALP00000029853 ---------LSESCNSK--------------RPRLIVFFCT-KPVEH-------------------------------------------------------------SLDSGDGP---P A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000017288 ---------------------------------------------------------------------------------------------------------------GMNLP---A X_tropicalis_ENSXETP00000015203 ---------VQEST-----------------PSRPRRQFCR-EYNEE-------------------------------------------------------------SIDDGDGP---G M_domestica_ENSMODP00000001598 ---------VCDSC-----------------PPHKQLRLSV-ETMEH-------------------------------------------------------------SLDNGDGP---P D_rerio_ENSDARP00000024255 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000014096 ---------------------------------------------------------------------------------------------------------------TKTIH---G G_aculeatus_ENSGACP00000024809 -------------------------------------------------------------------------------------------------------------------M---D M_musculus_ENSMUSP00000031895 ---------VCESC-----------------PPHKQLRLST-DATEH-------------------------------------------------------------SLDNGDGP---P O_anatinus_ENSOANP00000005545 ---------SVSVCPVVVCPFLMVLGNSRLQPALSVGDLLP-EEMEH-------------------------------------------------------------SLDNGDGP---P B_taurus_ENSBTAP00000021099 ---------------------------------------------------------------------------------------------------------------TKILH---G R_norvegicus_ENSRNOP00000022672 ---------VCESC-----------------PPHKQSRLST-DTMEH-------------------------------------------------------------SLDNGDGP---P P_pygmaeus_ENSPPYP00000017020 ---------------------------------------------------------------------------------------------------------------PKVIH---G M_musculus_ENSMUSP00000091238 ---------------------------------------------------------------------------------------------------------------VKTIH---G O_anatinus_ENSOANP00000015596 PLRGKEQWTGSVKPFVPVPS-------------------------------------------------------------------------------------------TTKRE---Q M_mulatta_ENSMMUP00000016588 ---------VKLNT------------------VFWFSVYTT-DTVEH-------------------------------------------------------------SLDNKDGP---V D_rerio_ENSDARP00000071815 ---------------------------------------------------------------------------------------------------------------SVTDP---G D_rerio_ENSDARP00000083664 ---------TH-------------------------------KSMEM-------------------------------------------------------------CLD-ADSP---V E_caballus_ENSECAP00000003321 ---------VCESC-----------------PPHKQLRLST-DTVEH-------------------------------------------------------------SLDNGDGP---P P_troglodytes_ENSPTRP00000054330 ---------------------------------------------------------------------------------------------------------------PKIIH---G H_sapiens_ENSP00000311032 ---------------------------------------------------------------------------------------------------------------PKIIH---G M_domestica_ENSMODP00000005560 ---------------------------------------------------------------------------------------------------------------VKSLH---S P_pygmaeus_ENSPPYP00000020323 ---------VCESC-----------------PLYKKLRLST-DTVEH-------------------------------------------------------------SLDNKDGP---V H_sapiens_ENSP00000312664 ---------VCESC-----------------PLYKKLRLST-DTVEH-------------------------------------------------------------SLDNKDGP---V P_troglodytes_ENSPTRP00000033921 ---------VCESC-----------------PLYKKLRLST-DTVEH-------------------------------------------------------------SLDNKDGP---V D_rerio_ENSDARP00000006831 ---------------------------------------------------------------------------------------------------------------GASAS---Q R_norvegicus_ENSRNOP00000022693 ---------------------------------------------------------------------------------------------------------------M-------- M_musculus_ENSMUSP00000026062 ---------------------------------------------------------------------------------------------------------------A-------- M_domestica_ENSMODP00000036247 ------RNNLFLIYQNT--QPQEVY--------------------------------------------------------------------------------------DSAG----- E_caballus_ENSECAP00000019797 ---------------------------------------------------------------------------------------------------------------TKILH---G G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000007986 SAPLSRRRPMENTDQSSTSIASSQVIYANQGTPPKRNRESS-SYIEQMDDAPSPTDSLSNIRSTASVHSLFSRSDVRTQSNTAINHINTVQSPTSTKAATSYQINLHQGMDLFDGP---T B_taurus_ENSBTAP00000008706 ---------------------------------------------------------------------------------------------------------------G-------- C_familiaris_ENSCAFP00000032189 ---------------------------------------------------------------------------------------------------------------TVIV----- D_rerio_ENSDARP00000072390 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000038128 QSLPE-EGYSKMPAMSD--SP-EQD--------------------------------------------------------------------------------------SELQ----- G_aculeatus_ENSGACP00000016983 -------------------------------------------------------------------------------------------------------------TLHAPVQ---D G_gallus_ENSGALP00000013506 SLRNKKYSVTGASAACHAISMPSTG----------------------------------------------------------------------------------------------- A_gambiae_AGAP000830-PA -----------------------------------------------------------------------------------------------------------------------P T_guttata_ENSTGUP00000010625 -------DSVDHIKQSTLGLPGEDR--------------------------------------------------------------------------------------SLSF----- G_aculeatus_ENSGACP00000013740 ---------TQEVV------------------AAKRARTQA-ESMEF-------------------------------------------------------------SLD-ADSP---I M_mulatta_ENSMMUP00000015808 ---------------------------------------------------------------------------------------------------------------PKIIH---G G_gallus_ENSGALP00000013571 LSISENLAVSSLIDN------------------------------------------------------------------------------------------------KESQE---S G_gallus_ENSGALP00000014503 ---------------------------------------------------------------------------------------------------------------EEQPK---S A_gambiae_AGAP011951-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000003106 ---------------------------------------------------------------------------------------------------------------M-------- O_latipes_ENSORLP00000015114 ---------IHDSE-----------------GLQLEMRTNT-ESMES-------------------------------------------------------------SLD-ADSP---I C_familiaris_ENSCAFP00000016420 ---------------------------------------------------------------------------------------------------------------G-------- P_troglodytes_ENSPTRP00000005216 ---------------------------------------------------------------------------------------------------------------M-------- T_nigroviridis_ENSTNIP00000009934 ---------------------------------------------------------------------------------------------------------------GSSSS---G G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010793 ----------------------------------------------------------------------------------------------------------------ANQP---N B_taurus_ENSBTAP00000024166 ---------VCESC-----------------TRHKRLHLSP-DAVEH-------------------------------------------------------------SLDHGDGP---P G_gorilla_ENSGGOP00000007184 ---------------------------------------------------------------------------------------------------------------X-------- T_rubripes_ENSTRUP00000045375 PVDVVRRDKAPVIPVPQPST----------------------------------------------------------------------------------------APSPSPER---E G_gallus_ENSGALP00000013591 STGAPEDSAIWLASSVAPDSLGNCD----------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000013855 ---------EPVSPVPKPST----------------------------------------------------------------------------------------PGRASPEV---E A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------------------------------------------------------------IP---V A_aegypti_AAEL003444-PA -----------------------------------------------------------------------------------------------------------------------S O_cuniculus_ENSOCUP00000009498 ---------------------------------------------------------------------------------------------------------------K-------- T_guttata_ENSTGUP00000011206 ---------------------------------------------------------------------------------------------------------------EEQPK---P A_gambiae_AGAP004921-PA -----------------------------------------------------------------------------------------------------------------------Q H_sapiens_ENSP00000358327 ---------------------------------------------------------------------------------------------------------------M-------- A_carolinensis_ENSACAP00000001629 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000063081 -----------------------------------------------------------------------------------------------------------------------L X_tropicalis_ENSXETP00000008971 GTESLIEHTGMIHEEAEKEDDKSGN--------------------------------------------------------------------------------------INHQL---S T_guttata_ENSTGUP00000017449 ----LELQEANQRCAVVLQTAAR--------------------------------------------------------------------------------------DVAAGIP---L T_rubripes_ENSTRUP00000037606 ---------TQEAV-----------------PGVCVCVCET-ESLEV-------------------------------------------------------------SLD-ADSP---I E_caballus_ENSECAP00000013731 ---------------------------------------------------------------------------------------------------------------E-------- C_familiaris_ENSCAFP00000005409 ---------MCESC-----------------PPQKQLRLSP-DTVEH-------------------------------------------------------------SLDNGDGP---P D_rerio_ENSDARP00000034228 ITDVFMFCFLGGVSQPEPPVPE--------------------------------------------------------------------------------------PIPKDPAQLKEL T_nigroviridis_ENSTNIP00000022078 ---------------------------------------------------------------------------------------------------------------MREQD---Y D_melanogaster_FBpp0084848 ---------------------------------------------------------------------------------------------AGSSHPYGSGAIGQLANGYSSPS---S M_mulatta_ENSMMUP00000001627 ---------------------------------------------------------------------------------------------------------------G-------- T_rubripes_ENSTRUP00000040691 ---------------------------------------------------------------------------------------------------------------SGSSS---G A_gambiae_AGAP011950-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000047019 PLRPESLPV---------------------------------------------------------------------------------------------------HKTYSPPS---E C_familiaris_ENSCAFP00000023986 VLGP-----AELQPQVVRPSVPRP------------------------------------------------------------------------------------TDNGSGRF---S T_rubripes_ENSTRUP00000031759 ---------------------------------------------------------------------------------------------------------------MREQD---Y C_intestinalis_ENSCINP00000024485 KNQQKSNAFQPNSHLPVASGFNSLSKQEYNHTSKLEPQYVSMENHRA-------------------------------------------------------------FNGGYNQY---N A_gambiae_AGAP011952-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000017899 QLPIR-EGSVKILPMSD--SLGEQD--------------------------------------------------------------------------------------YESE----- A_gambiae_AGAP011949-PA ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022402 ---------------------------------------------------------------------------------------------------------------SSSAS---A T_nigroviridis_ENSTNIP00000001216 ENQSSSRTEASVMSSANAVGIKPGT--------------------------------------------------------------------------------------LMLGL---S A_gambiae_AGAP004920-PA -----------------------------------------------------------------------------------------------------------------------E X_tropicalis_ENSXETP00000003217 ---------------------------------------------------------------------------------------------------------------SLQNC---D O_latipes_ENSORLP00000010095 --------------------------------------------------------------------------------------------------------------GASPAP---D T_rubripes_ENSTRUP00000024164 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000006351 IIPIIYDEIILLPTESS--FRGHSG--------------------------------------------------------------------------------------GEAE----- M_musculus_ENSMUSP00000030747 VLGPEELWPARLKPEVLRPETPRP------------------------------------------------------------------------------------VDIGSGGA---H D_rerio_ENSDARP00000019984 ---------------------------------------------------------------------------------------------------------------LQEKG---- G_aculeatus_ENSGACP00000005791 VPQSLGAEGTGLFEMQDSPSGFNGGGDCAALSLGLSGHLKIEVVETM-------------------------------------------------------------PPPKNMSC---S C_familiaris_ENSCAFP00000016791 -----------------------------------------------------------------------------------------------------SSATCGLRRAYRTAD---E C_intestinalis_ENSCINP00000003204 ------------------------------------------------------------------------------------------------------------ALGSGETP---R G_aculeatus_ENSGACP00000008661 ---------------------------------------------------------------------------------------------------------------TREQD---Y E_caballus_ENSECAP00000015102 VLGPEELWLAKLRPEVLRPEVPRP------------------------------------------------------------------------------------VDIGSGGF---S B_taurus_ENSBTAP00000003205 VLGPEELWPAKLRPEVLRPEVPRA------------------------------------------------------------------------------------VDAGSGGF---T G_aculeatus_ENSGACP00000007379 PVHLTHCD----------------------------------------------------------------------------------------------------AHVTAPER---E C_elegans_C48D1.2 RSRSRALHSSDRHNYSSPPVNAFPSQPSSANSSFTGCSSLGYSSSRNRSFSKA-------------------------------------------------------SGPTQYIF---H A_gambiae_AGAP009832-PA ---------------------------------------------------------------------------------------------------------------ASGSQ---T D_rerio_ENSDARP00000093958 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000032442 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000002083 ------LELPGERRDKSVSTAERLSI----------------------------------------------------------------------------------PVQPESER---F A_gambiae_AGAP012544-PA ---------------------------------------------------------------------------------------------------------------MDATIINNN D_rerio_ENSDARP00000075318 ----------------------------------------------------------------------------------------------------------RLLVPVPETE---L R_norvegicus_ENSRNOP00000017972 VLGPEELWPTRLRPEVLTPETPRP------------------------------------------------------------------------------------VDIGSGRA---H H_sapiens_ENSP00000286186 SWQNKHAGSNGNRATNGAPSLVSRG----------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000014602 SWQNKHAGSNGNRATNGAPSLVSRG----------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000014606 ------EELCGVMTISD--SPREQD--------------------------------------------------------------------------------------SESQ----- A_aegypti_AAEL014348-PA -----------------------------------------------------------------------------------------------------------------------Q M_musculus_ENSMUSP00000029626 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003208 VKVPHNIFIDKVKSDIFDSKSRFR------------------------------------------------------------------------------------NNDNTNVC---T D_melanogaster_FBpp0071971 -----------------------------------------------------------------------------------------------------------VGGATAASP---L O_anatinus_ENSOANP00000002508 ---------------------------------------------------------------------------------------------------------------SQSGG---- M_mulatta_ENSMMUP00000037892 ------EELCGLMTISD--SPREQD--------------------------------------------------------------------------------------SESQ----- T_rubripes_ENSTRUP00000044662 -NRCPLLTAASLLEQS-------------------------------------------------------------------------------------------------CSF---N D_rerio_ENSDARP00000075650 -----------------------------------------------------------------------------------------------------------------------L E_caballus_ENSECAP00000013268 ------------------------------------------------------------------------------------------------------------------GE---E X_tropicalis_ENSXETP00000035938 ---------------------------------------------------------------------------------------------------------------DPEKP---P A_aegypti_AAEL011562-PA EEDDAKNNNDTVEETTDKGGKRRL---------------------------------------------------------------------------------------QEFGE---K E_caballus_ENSECAP00000004055 KCLQR-EGSLAGQAMSD--SPGQQN--------------------------------------------------------------------------------------SESQ----- 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000221740 ----------MSNPRSLEE-EKYDM--SGARLALILCVT-------------------KAREGSEEDLDALEHMFRQLRFEST-MKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLM M_mulatta_ENSMMUP00000024183 ----------MSNLRSSEE-EKYDM--SGARLALTLCVT-------------------KAREGFEEDLDALEYMFRQLRFEST-MKRDPTAQQFQEELEKFQQAIDSREDPISCAFVVLM C_familiaris_ENSCAFP00000023821 -----MVDSEIRQAQLLAQ-EAYDM--SGARLALTLCVT-------------------KAREGSEADLDALERMFQQLGFEST-MKRDPTAQQFQEELDKFQQAMDARDDFISCAFVVLM E_caballus_ENSECAP00000010379 ------------------Q-EAYDM--SGARLALTLCVT-------------------KAREGSEADLDALERMFQQLGFEST-TKRDPTAQQFQEELEKFQQAMDAREDLVSCAFVVLM B_taurus_ENSBTAP00000028116 ------ESKEMSSPQPLEE-ETYDM--SGARLALTLCVT-------------------KAREGSEADLDALERMFQQLGFEST-MKRDPTAQQFQEELEKFQQAIDAREDFVSCAFVVLM O_cuniculus_ENSOCUP00000002346 --------------------ERYDM--SGARLALTLCVT-------------------KAREGSEADLDALERMFQQLGFEST-VKRDPTAQQFQEELEKFQQTIDAWKDPVSCAFVVLM R_norvegicus_ENSRNOP00000009643 ------MDSETINPQPLQE-ERYDM--SGARLALTLCVT-------------------KAREGSEVDMDALERMFQYLKFEST-MKRDPTAQQFLDDMDEFQQTIENWKEPVSCAFVVLM P_pygmaeus_ENSPPYP00000010831 ----------MSNLRSLEE-EKYDM--SGARLALTLCVT-------------------KAREGSEEDLDALEHMFQQLRFEST-MKRDPTAQQFQEELEKFQQAIDSREDPVSCAFVVLM M_musculus_ENSMUSP00000005488 ------MESEMSDPQPLQE-ERYDM--SGARLALTLCVT-------------------KAREGSEVDMEALERMFRYLKFEST-MKRDPTAQQFLEELDEFQQTIDNWEEPVSCAFVVLM G_gorilla_ENSGGOP00000000424 ----------MSNPRSLEE-EKYDM--SGARLALTLCVT-------------------KAREGSEEDMDALEHMFRQLRFEST-MKRDPTAQQFQEELEKFQQTIDSREDPVSCAFVVLM M_domestica_ENSMODP00000018104 --------------------DVYNM--SDARLALTLCIT-------------------KNRAGSETDVQALEKMFKALNFKNT-VRRNIPAKGFWEELEKFRDDMDQMKDPVSCCFVVLM O_anatinus_ENSOANP00000013840 ----------LPHSSSSPQ-MVYDM--SGARLALTLCIT-------------------KDREGAEPDIAALERMYQALRFEST-VRRDPPAKAFRDELVRFREEMEGRKDPVSCCFVVLM M_domestica_ENSMODP00000020556 ------LLLWLPQLSPIPQ-GVYDT--SGAKVALVLCVT-------------------RDRPGAKQDLKALKRLFQTLGFKSI-LKMNPTAQDFRKELTRFRELLDARRTNVSCALVALM E_caballus_ENSECAP00000006138 ALCLGDTEPWGLEPEPSPS-AQYDL--SGARVALLLAVI-------------------RGRSGAQHDVEALWGLCQALGFETT-LMTDPTAQAFQEELAQFREWLDAHRGPVSCALVALM M_mulatta_ENSMMUP00000027593 --------------APGPN-TQYDL--SKTRAALLLAVI-------------------QGRPGAQHDVEALGGLCRALGFETT-VRTDPTAQAFQEELAQFQKQLDTCRGPVSCVLVALM B_taurus_ENSBTAP00000045524 ------VEPWGPEPEPGPS-AQYDL--SGARAALLLAVT-------------------QGRLGAQHDVEALEGLCQALGFETT-LRTDPTAQTFQEEMAQFRKRLDAHRGPVSCALVALM B_taurus_ENSBTAP00000012869 PVIPRKSLKRSYDCVDGEL-YRYDL--SGRRKAFLMCVK-------------------KNRLGAHQDVQLMKDWLKECKFEPT-LCIDPDKMDLLGKITSFRDELNEIKDDIGCCLVTLM M_domestica_ENSMODP00000032734 KSMSRMNLKRPYEDDSSEL-DRYNM--DRTRKAFVMCVK-------------------TGRPGAKQDISRIKNWLEKCKFEYT-YCDDPDEEELFEKLTQFRDGINGIKEEVSCCLVTLM C_familiaris_ENSCAFP00000007585 ERIPRKILKRSYDCVDGEL-DRYDL--SGSRKAFLMCVE-------------------KSRPGAHRDIELMKEWLGQCQFEHT-ACIDPNKMELLRKITLFRDGLNEIKGDVGCCLITLM O_cuniculus_ENSOCUP00000000197 ALCLTSEEPWRPEAEPGPG-AQYDM--SGARAALLLAVI-------------------RDRPGAERDVEALGGLCQALGFETT-LRTDPTAQAFWEKLGQFQEQLDTYRGPVSCALVALM A_carolinensis_ENSACAP00000013788 --------------------DHYGM--KKKRVAFMMCVT-------------------EGRAGAEEDIKKMKKWFRTFKFTLLGDCRNPGQETLMQQLRQFRDIINLSNEEISCCLITLM O_anatinus_ENSOANP00000019254 ----IDSPMCHPSPGDENQ-KRYDM--SKCREAFLMGVK-------------------KGRSGATEDIEKLRKHLAAFRFSVQ-ECIDPDGKVILQDLREFRDKINGSPYEMSCCLVILM E_caballus_ENSECAP00000017996 -------------------------------------VK-------------------RNRPGAQHDVMLMKEWLGQCQFEHT-SCIDPDKMELLGKITSFRDGLNEIKDEIGCCLVTLM T_guttata_ENSTGUP00000006879 SKSMDS--------GILPD-YSYRM--DYPEMGECIIINNKNFH--RYT-------GMSPRSGTDADAASVREVFMKLGYKIK-INNDLSCEGIFNLLKNV-SEED--HSKRSSFVCVLL A_carolinensis_ENSACAP00000006831 YPQ--VMPCTPEFYRTHEQ-LAYKL--KSQPRGLALILSNIHFN--KET-------DLDFRSGGDVDNTALHMLFKHLGYQVV-VRQDRTAQEMKEELEIFSKHPA--HRNVDSCIVSLL O_anatinus_ENSOANP00000000517 KQFLGS--------SASLD-DRYRM--DYPNMGICLIINNKNFH--PDT-------RMGCRSGTDVDAASLRDTFKKLKYEVR-CKNDLKRREILELLTSV-AHED--HSKRSSFVCVLL T_guttata_ENSTGUP00000013612 IPP--VKYCTPEFYHNHQH-LAYKL--TSEPRGLALILSNVRFS--SEK-------DLEYRAGGDVDCASLEMLFRHLGYRVT-VFCDQTAQDMQNALERFSKLQD--HRDVDSCIIALL M_domestica_ENSMODP00000005556 SKSVES--------GLS-S-DSYKM--DYPEMGLCIIINNKNFH--PNT-------GMSFRSGTDVDAASLSDTFRSLKYEVR-IKNDLTCNEITELLNSV-SKED--HSQRSSFICVIL G_gallus_ENSGALP00000029853 IPP--VKHCTPEFYRDHQH-LAYKL--ISEPRGLALILSNIHFS--SEK-------DLEYRSGGDVDCASLELLFKHLGYQVT-VFHDQSAEEMESALERFSKLPD--HQDVDSCIVALL A_carolinensis_ENSACAP00000009923 -----------------PT-FRYRM--DYKKLGKCVIINNKNFA--KDT-------GMRIRNGTDKDAGDLQKCFRGIGFDVS-IYNDLTCDNMEKILGEA-ALEN--HDDAACFACILL G_gallus_ENSGALP00000017288 SKSVDS--------GILPD-DSYRM--DYPEIGVCVIINNKNFH--RDT-------GLSSRSGTDADAASVREVFMKLGYKVK-LNNDLSSRDIFKLLKNV-SEED--HSKRSSFVCVLL X_tropicalis_ENSXETP00000015203 T----VQLCSVDFYLSHHQ-QAYKM--HSCPRGRALIISNVAFE--TQ--------DLDHRYGGEVDVTSLEKLFSSLGFQVE-VRRNLNAQNMMSQLGAFSALPA--HSALDSCVVAVL M_domestica_ENSMODP00000001598 SLQ--VKPCTPEFYQTHQH-LAYRL--QSRPRGLAMVLSNVHFN--GEK-------DLEFRSGGDVDHSSLVTLFKLLDYDVH-VLRDQTAQKMQENLQRFAQLSA--HQSTDSCMVALL D_rerio_ENSDARP00000024255 --------------------EQYEM--KGERRGVCLIINNYDFS--AC--------GWLNREGTDIDHDSLRDVFEWLGFEIL-TRRDCTGDQILQALMDL-STQD--HTQADCVVCCIL R_norvegicus_ENSRNOP00000014096 SKSMDS--------GIYLD-SSYKM--DYPEMGLCIIINNKNFH--KST-------GMSARNGTDVDAANLRETFMALKYEVR-NKNDLTREEIMELMDSV-SKED--HSKRSSFVCVIL G_aculeatus_ENSGACP00000024809 KLYRDV-------QSGEDK-YRYKM--DYPCMGTCVIINIKNFD--LKT-------GLETRNGTDVDAAELEKTFSKLGYKVT-LVHDQTADQIVDLLRDV-STQD--HSNSGSFVCVLL M_musculus_ENSMUSP00000031895 CLL--VKPCTPEFYQAHYQ-LAYRL--QSQPRGLALVLSNVHFT--GEK-------DLEFRSGGDVDHTTLVTLFKLLGYNVH-VLHDQTAQEMQEKLQNFAQLPA--HRVTDSCVVALL O_anatinus_ENSOANP00000005545 CPQ--VKPCTPEFYRVHHH-LAYRL--ESRPRGLALVLSNMRFN--GEK-------DLEFRSGGDVDHNALITLFKHLDYSVE-FLRDQTAQEMQEKLHNFAQSPR--HRFTDSCVVALL B_taurus_ENSBTAP00000021099 SKSMDS--------GISLE-ESYKM--DYPEMGLCIIINNKNFH--ENT-------GMCRRSPTDDSVAQXRETFMNLKYEVR-IKNDLTCKEMLELMSNV-SKED--HSKRSSFICVLL R_norvegicus_ENSRNOP00000022672 CLQ--VKPCTPEFYQAHYQ-LAYRL--QSQPRGLALVMSNVHFT--GEK-------DLEFRSGGDVDHTTLVTLFKLLGYNVH-VLYDQTAQEMQEKLQNFAQLPA--HRVTDSCIVALL P_pygmaeus_ENSPPYP00000017020 SKSMDS--------GISLD-NSYKM--DYPEMGLCIIINNKNFH--KST-------GMASRSGTDVDAANLRETFRNLKYEVR-NKNDLTREEIVELMRDV-AKED--HSKRSSFVCVLL M_musculus_ENSMUSP00000091238 SKSVDS--------GIYLD-SSYKM--DYPEMGICIIINNKNFH--KST-------GMSSRSGTDVDAANLRETFMGLKYQVR-NKNDLTREDILELMDSV-SKED--HSKRSSFVCVIL O_anatinus_ENSOANP00000015596 EATR--PGE----KQGMAI-KVYSL--KSEPCGHCLIINNVDFS--LGS-------GLSTRTGSDVDCEKMKRRFRLLHFEVA-VERNLTAEEMVKALNKL-AKKD--HSALDCCVVVIL M_mulatta_ENSMMUP00000016588 CLQ--VKPCTPEFYQTHFQ-LAYRL--QSRPRGLALVLSNVHFT--GEK-------ELEFRSGGDVDHSTLVTLFKLLGYDVH-VLRDQTAQEMQEKLQNFARLPA--HRVTDSCIVALL D_rerio_ENSDARP00000071815 LVQMDAKSH----SDDNVD-YQYKT--NYPNLGQCLIINNKNFH--KRT-------GMGVRNGTDEDAKKVFETFSQLGFKVG-HYNDLTVSQMMALLNKA-SQED--HSKSAMFACVLL D_rerio_ENSDARP00000083664 TTA--VLPCTPEFYQSHRP-QAYPM--RSCPRGLALVLSNVRFD-SANT-------DLDIRRGGEVDEETLRRLFTELDFKVS-LHRDLTAEAMRRCLEQFAQQQE--HAAYDCAVVCLL E_caballus_ENSECAP00000003321 CLQ--VKPCTPEFYQAHYQ-LAYRL--QSRPRGLALVLSNVHFT--GEK-------DLEFRSGGDVDHSTLVTLFKLLGYNVH-VLLDQTAKEMQEKLQNFAQLPA--HRVTDSCIVALL P_troglodytes_ENSPTRP00000054330 SQSMDS--------GISLD-NSYKM--DYPEMGLCIIINNKNFH--KST-------GMTSRSGTDVDAANLRETFRNLKYEVR-NKNDLTREEIVELMRDV-SKED--HSKRSSFVCVLL H_sapiens_ENSP00000311032 SESMDS--------GISLD-NSYKM--DYPEMGLCIIINNKNFH--KST-------GMTSRSGTDVDAANLRETFRNLKYEVR-NKNDLTREEIVELMRDV-SKED--HSKRSSFVCVLL M_domestica_ENSMODP00000005560 SKSVES--------GLS-S-DSYKM--DYPEMGLCVIINNTHFH--NDT-------ELSPRTGSDKDAANLIDIFRSLKYEVR-NKNNLTRDKMIELLRQV-SEED--HSQRSSFVCVIL P_pygmaeus_ENSPPYP00000020323 CLQ--VKPCTPEFYQTHFQ-LAYRL--QSRPRGLALVLSNVHFT--GEK-------ELEFRSGGDVDHSTLVTLFKLLDYDVH-VLCDQTAQEMQEKLQNFAQLPA--HRVTDSCIVALL H_sapiens_ENSP00000312664 CLQ--VKPCTPEFYQTHFQ-LAYRL--QSRPRGLALVLSNVHFT--GEK-------ELEFRSGGDVDHSTLVTLFKLLGYDVH-VLCDQTAQEMQEKLQNFAQLPA--HRVTDSCIVALL P_troglodytes_ENSPTRP00000033921 CLQ--VKPCTPEFYQTHFQ-LAYRL--QSRPRGLALVLSNVHFT--GEK-------ELEFRSGGDVDHSTLVTLFKLLGYDVH-VLCDQTAQEMQEKLQNFAQLPA--HRVTDSCIVALL D_rerio_ENSDARP00000006831 PMQVDA-------KPQSHA-FRYSL--NYPNIGHCIIINNKNFD--RRT-------GMNPRNGTDVDAGNVMNVFRKLGYIVK-VYNDQTVAQIMQVLTTV-AHDD--HSRCASLVCVLL R_norvegicus_ENSRNOP00000022693 CPVSTT-------RDRVPT-YLYRM--DFEKMGKCIIINNKNFD--KAT-------GMDVRNGTDKDAEALFKCFRSLGFEVT-VYNDCSCAKMQDLLRRA-SEED--HSNSACFACVLL M_musculus_ENSMUSP00000026062 GPVRTG-------RDRVPT-YLYRM--DFQKMGKCIIINNKNFD--KAT-------GMDVRNGTDKDAGALFKCFQNLGFEVT-VHNDCSCAKMQDLLRKA-SEED--HSNSACFACVLL M_domestica_ENSMODP00000036247 ----------------EKG-NVYKM--SSRPRGYCLIINNFDFK--ISRKERPENHYLTDRRGTNKDEEALKNIFKELHFDIQ-SFQDLTAEGIQQVLKTF-KDNN--HESKDCFVCCLL E_caballus_ENSECAP00000019797 SKSMDS--------GISLD-SSYKM--DYPEMGLCIIINNKNFH--KST-------GMASRSGTDVDAANLRETFTNLKYEVR-NKNDLTGEEIVALMRSV-SKED--HSKRSSFICVLL G_aculeatus_ENSGACP00000024816 ---------------------------------------------------------MSPRNGTDVDAADAFRTFSKLGYKVT-VANDQTVDQMIQLLVKV-SKQD--HSNSASFVCVLL C_intestinalis_ENSCINP00000007986 VSDLTVRKSTHQHLMQHTDCYQMTM--RGRPKGAALIISVEKFH--PES-------DLLNREGSEKDRVRLELVLQQIGFQCY-VLINGTAEQIVSTLQTFAELEE--HYDNSCSLVAAM B_taurus_ENSBTAP00000008706 KSVNIP-------RDRVPT-YQYNM--NFEKVGKCIIINNKNFD--RIT-------GMGVRNGTDKDAEALFKCFRSLGFDVS-VYNDCSCAKMQDLLKKA-SEED--HRNSACFACILL C_familiaris_ENSCAFP00000032189 -KILKD--------KYLTK-LHYKM--DYPEMGLCIIINNKNFH--KST-------GMAPRSGTDVDAANLRETFTNLKYEVR-NKNDLTCEEILELMNSV-SKED--HSKRSSFVCVLL D_rerio_ENSDARP00000072390 ------------------AFEPYK---KHKNIGKCLIISNEHFP--VQF-------SLNRKKGNSVDERRLSSTFKSLGFHVK-VENNLSANQMIDALRTV-SEED--HTDNSCFVCVLM B_taurus_ENSBTAP00000038128 ----------------TSD-TVYRM--TSKPRGYCLIFNNYDFS--IARKQVPELHDLKDRTGTDFDADALDKTFRELHFEIV-HYKDLTAKGICEVLESY-QKKD--HKNKDCFICCIL G_aculeatus_ENSGACP00000016983 TSVGHSDVRPPPSKKLKKD-ERYEL--NSQPSGLCVIINNKNFS--------------KPRRGSDKDAESLGEVFTWLGFRAL-MCKDQTKDQMERALNKF-TALQEAPRHGDALICCIL G_gallus_ENSGALP00000013506 -VQNALANTTVCYSSFLQV-SSYKM--DGPRRGICLVINNVKFD-----------GVLQERKGSYKDACELERVFTWLGLDVR-TYTDQTSDQIKELMQAWQRSED--HKNRDCFVCCIL A_gambiae_AGAP000830-PA TNHLVRARM----PVERYA-CDYNM--NHKRRGLALIFNHENFD--VP--------QLRSRAGTNVDCENLTASLKGLDFEVH-VFKDLKLRDLQKEVERV-SQMD--HSDADCLLVTIL T_guttata_ENSTGUP00000010625 ----------------QLL-EAYKM--TSRPCGVCLILNNHNFA--KAREGVLEHKHMKDRNGTDVDAAALRNVFSKLHFRVE-EYRDLTAEEIRETVNIF-QSAD--HEDKDCFVCCIL G_aculeatus_ENSGACP00000013740 NSP--VLPCTPDFYLSHCH-QSYRM--NSSPRGFALVISNVTFDPCAAP-------DLDPRKGGEVDDEVLRKVFTELDYVVK-VHRDLTAQDMRTCIEEFSRRPD--HRTMASCVVCLL M_mulatta_ENSMMUP00000015808 SKSVDS--------GISLE-NSYKM--DYPEMGLCIIINNKNFH--KST-------GMASRSGTDVDAANLRETFINLKYEVR-NKNDLTREEIVELMRNV-SKED--HSKRSSFVCVLL G_gallus_ENSGALP00000013571 QSEWYSAGIFPPHVQILLV-ESYKM--ENNPHGYCVILNNYRFK--NPN---------ETRKGTVEDGKALKRVFKWLQFDTI-EYMDLEAKQIFAKVNEY-SKKD--HSNMDCFVCFIL G_gallus_ENSGALP00000014503 SLSNQY-------RIVTPT-FQYNM--NYKKVGKCIIINNKNFE--DKT-------GMGTRNGTDKDAGDLSKSFRSLGFDVY-TYNDRSCEDMQTLLKQA-AEEN--HSDAACFACILL A_gambiae_AGAP011951-PA --------------------ECYDT--SNARRGIALIINQVIFS------------SMAVRVGSSKDRTDISTVLQRIGFEVR-VMDDPNRKQLLSALKQL-AGED--HSHSDCLVVVVM P_pygmaeus_ENSPPYP00000003106 QSIKTT-------RDRVPT-YQYNM--NFEKLGKCIIINNKNFD--KVT-------GMGVRNGTDKDAEALFKCFRSLGFDVI-VYNDCSCAKMQDLLKKA-SEED--HTNAACFACILL O_latipes_ENSORLP00000015114 NTP--VLACSADFYLSHCQ-QSYRM--NSSPRGSVLVISNINFDPRAAP-------ELDPRKGGEVDDEVLRKLFTELDYSVN-FHRDLTAQDMKMVIENFCRRPD--HQKVDSCVVCLL C_familiaris_ENSCAFP00000016420 RSIKTA-------QDQVPT-YQYNM--NFEKVGKCIIINNKNFD--KTT-------GMGVRNGTDKDAEALFKCFRNLGFDVV-IYNDCSCAKMQDLLKKA-SEED--HRNSACFACILL P_troglodytes_ENSPTRP00000005216 RSIKTT-------RDRVPT-YQYNM--NFEKLGKCIIINNKNFD--KVT-------GMGVRNGTDKDAEALFKCFRSLGFDVI-VYNDCSCAKMQDLLKKA-SEED--HTNAACFACILL T_nigroviridis_ENSTNIP00000009934 KMTVDA-------KSARYS-FRYSL--DFPNLGHCIIINNKNFD--RRT-------GMNTRNGTDVDAANAMKVFSNLGYRVR-VHNDQTVAQISQLLTSA-AKED--HSRCASFVCILL G_aculeatus_ENSGACP00000024812 -----------------DK-YRYKM--DYPCMGTCVIINNKTFD--PKT-------GLSPRNGTDVDAAELEKTFSRLGYKVT-VANDQTADQMVDLLADV-SKQD--HRKSASFVCALL O_latipes_ENSORLP00000010793 PRSTDVCVI----KQDADP-YRYSM--DYPKMGICLIINNKNFH--KDS-------GMGPRNGTDNDAAAAWKSFMKLGYEIQ-MYNDQTVDQMKKLFRQM-SNQD--HSKFASFACVIL B_taurus_ENSBTAP00000024166 CLQ--VKPCTPEFYQTHHH-LAYRL--QSRPRGLALVLSNVHFT--GEK-------DLEFRSGGDVDHSTLVTLFKLLGYKVH-VLLDQTAQEMQEKLQNFAQLPV--HRVTDSCIVALL G_gorilla_ENSGGOP00000007184 XXXXXX-------XXXXXX-XXXXX--XXXXXXXXXXXXXXXFD--KVT-------GMGVRNGTDKDAEALFKCFRSLGFDVI-VYNDCSCAKMQDLLKKA-SEED--HTNAACFACILL T_rubripes_ENSTRUP00000045375 YMRLKPQGR----IRRDSI-QSYKM--DANPSGHCLIINNVDFE--PRS-------ELNDRKGSNTDCDRLESRFKALNFIVK-VKTNLKQRQIKHELSAL-SKMD--HSQYDCCVVVLL G_gallus_ENSGALP00000013591 --------------QSSQL-EVYKM--TSRPRGVCLILNNHNFA--KAREAVPELRRMKDRNGTHVDADALRKVFSNLHFTVA-EYKDCTAEEIRNIVNNY-RCMD--HNNKDCFVCCIL T_nigroviridis_ENSTNIP00000013855 YVTL--KGR----IRRDSL-QSYRM--EANPLGHCLIINNVEFE--PKS-------GLSNRNGSNVDCDRLERRFKALNFTVK-VKTNLKQRQIRQELSAL-SKVD--HSQYDCCVVVIL A_carolinensis_ENSACAP00000002670 SKSVDS--------VIEAD-ESYRM--DHPEMGLCILVNNKNFH--PAT-------GMSYRSGTDRDAAHVVDTFRTLGYMVK-PYNDLTCKQIVDVLHNV-SKDD--HHKRNSFVCVLL A_aegypti_AAEL003444-PA SKSIKEALV----SRAALD-EYYDT--TNKRRGIALVFCHMNFS------------VMAKRNGADKDRDDICNTLYGLDFDVR-VFDDLSRKEVLDRLKDV-SRED--HSDNDCLVVVMM O_cuniculus_ENSOCUP00000009498 QSAKAT-------RDQVPS-YQYNM--NFDKMGKCIIINNKNFD--KVT-------GMGVRNGTDKDAEALFKCFRSLGFDVM-VYNDCSCARMQDLLKRA-SEED--HTNSACFACILL T_guttata_ENSTGUP00000011206 SLSNQY-------RIVTPT-FQYNM--DYKKVGKCIIINNKNFE--DKT-------GMGTRNGTDKDAGDLAKSFKNLGFEVD-IHHDRSRDDMEKLLKKA-AEEN--HSDAACFACILL A_gambiae_AGAP004921-PA IASRQRSQN----ARALQE-EEYDT--NHRRRGMAIILNHENFE------------LMSKREGTNRDRDAATAVLTSMQFDVR-VYNDLGRDELFCVLLAL-ASED--HSDCDCLLVMLM H_sapiens_ENSP00000358327 RSIKTT-------RDRVPT-YQYNM--NFEKLGKCIIINNKNFD--KVT-------GMGVRNGTDKDAEALFKCFRSLGFDVI-VYNDCSCAKMQDLLKKA-SEED--HTNAACFACILL A_carolinensis_ENSACAP00000001629 --------------------TCYKM--DGLNRGSCLIFNNVHFE-----------GGLSQRRGSQKDAEELESVFRWLGLDVI-KYNDTTSIEMENHLKQWQSFEN--WKDMDCLVCCIL D_rerio_ENSDARP00000063081 ENFPVLEGHAIFASSVQKV-SQYKI--TQNPRGICVIINNVDFT------------SMGERRGSDEDQNYLAKVFRWLGFEVV-AHRNKTAAEMKNILQAL-GRTV----DGDCFVCCVL X_tropicalis_ENSXETP00000008971 DLRLNSEMT----PQANKE-EFYDM--NHKHRGYCLIIDNSVFM------------KGNRREGSDKDAGALSDVFSWLGLEVD-IFENLMSEQIRDCLKRF-KSRD--HSERDCFVCCIL T_guttata_ENSTGUP00000017449 TVGKSPE------VMSFII-LDYEM--KADPCGHCLILNNVNFC--RDS-------GLSTREGSDIDCEKLERRFKALCFTVL-TRRDLKAQEMVLELLKL-SRQD--HSALDCCIVVIL T_rubripes_ENSTRUP00000037606 NTP--VLPCTPDFYLSHFQ-QSYKM--ASSPRGFALVISNVTFNPCAAP-------ELDPRKGGEVDDEVLRKVFTELEYSVT-VQRDLTAQGIKTCIQNFSGRPE--HRSVDSCVVCLL E_caballus_ENSECAP00000013731 RSITTN-------RNREPT-YQYNM--NFEKVGKCVIINNKNFD--RGT-------GMGVRNGTDKDAEALFKCFRNLGFDVV-VYNDCSCAKMKSLLKQA-SEED--HRNSACFACILL C_familiaris_ENSCAFP00000005409 CLQ--VKPCTPEFYQTHYQ-LAYRL--QSRPRGLALVLSNVHFT--GEK-------DLEFRSGGDVDHSTLVTLFKLLGYKVH-VLLDQTAQEMKEKLQNFAQLPA--HRVTDSCIVALL D_rerio_ENSDARP00000034228 KVTPCSQQFKNKILREKGQ-ETYEIKDKSVRKRLALLINNVDFD-----------DKAMKRSGSEKDEENMEKLLKELDYQVV-KRPNLSAKEMDEAIRDFAQREE--HKYSDSAFVVIM T_nigroviridis_ENSTNIP00000022078 CSESHY-------RIVSPT-FQYRM--SHQRVGKCIIINNKNFD--EKT-------GMNVRNGTDRDAGELYKCFKSLGFDVF-IYNDQTCEKMEHLLREA-SEED--HSDSSCFACILL D_melanogaster_FBpp0084848 SYRKNVAKM----VTDRHA-AEYNM--RHKNRGMALIFNHEHFE--VP--------TLKSRAGTNVDCENLTRVLKQLDFEVT-VYKDCRYKDILRTIEYA-ASQN--HSDSDCILVAIL M_mulatta_ENSMMUP00000001627 QSIKTT-------RDRVPT-YQYNM--NFEKMGKCIIINNKNFD--KVT-------GMGVRNGTDKDAEALFKCFQSLGFDVI-VHNDCSCAKMKDLLKKA-SEED--HTNAACFACILL T_rubripes_ENSTRUP00000040691 RVTVDA-------KPAAYS-FRYSL--DFPNMGHCIIINNKNFD--RRT-------GMNTRNGTDVDAANAMKVFLSLGYKVK-VHNDQTVNQMKQLLVSA-AEED--HSACASFVCVLL A_gambiae_AGAP011950-PA ------MDS----LLELEL-QSYKT--NHPNRGIAVVINDS-----------------ENRDGWEKDLEAVETVLQRLKCDVR-TFCDKTKHEIRDALRNV-SKED--HTKSDCLVIVAM D_rerio_ENSDARP00000047019 TVVR--PTR----PRRDSI-QCYKM--DASPCGVCLIINNINFE--KAS-------ELNDRKGSNIDCDKLEKRFKALNFEVT-VKRNLKSKRIRHEMASL-AKKD--HSTYDCCVVIIL C_familiaris_ENSCAFP00000023986 DVCE--YQESGWWVAGPIK-LAYAL--NADPCGYCLIINNVNFC--PES-------RLTARGGSNIDCEKLQRRFCLLRFTVE-VKWDLTAKQMVQALVEL-ARRD--HSALDCCVVVVL T_rubripes_ENSTRUP00000031759 CSESHY-------RIVSPT-FQYKM--SHQRVGKCIIINNKNFD--EKT-------GMNVRNGTDRDAGELFKCFKTLGFDVF-IYNDQTCEKMERLLREA-SEED--HSDSSCFACILL C_intestinalis_ENSCINP00000024485 NYQSEIKDT----STMGIL-DKYPM----ERRGYCLIINNENFE--R-----------QDRTGSGNDTERLENLFKEFGFILD-VRKDLDQREMEKVIQEY-TKKD--HSDKDCFVCVVM A_gambiae_AGAP011952-PA --------------------ENYDT--SHRNRGTALIFNHVNFE------------SNAKREGSNKDRDEIKKELLQLGFDAR-VFNDLKKQELLAKLDEV-AKED--HTESDCFVLVMM C_familiaris_ENSCAFP00000017899 ----------------TSD-KVYRM--KSKPRGYCLIFNNYDFS--VARREVPKLQSIKDRNGTDLDADALSKTFSELHFEIV-HFKDATAKKICEVLQSY-QSMD--HSSKDCFICCIL A_gambiae_AGAP011949-PA ------MDS----ILEFEL-KSYDT--THPNRGIAVVINDS-----------------ERREGSEKDVQDVVATLEGLKFNVR-TFQDNTKKEIKKALYKV-ARED--HNENDCLVIVAM G_aculeatus_ENSGACP00000022402 PEEVDA-------KPNVHS-FRYSL--SFPSIGQCIIINNKNFD--RGT-------GMNQRNGTDVDAANAMKVFGNLGYKVK-VYNDQSVAQIQHVLTSV-SKQD--HSCSASFVCVLL T_nigroviridis_ENSTNIP00000001216 PPPVGSPNF----P-VQDL-GTYPM--TTLPRGCCLIISNYDFQ--GS--------GLGMRNGTRTDEECLKKVFEWLGFKVE-IHRDCTGKEILSLMQEL-ADKS--QQRWDCLVCCIL A_gambiae_AGAP004920-PA IISSSVIHE----LEPVDD-AHYNM--SHNRRGVAAVFNHRKFL------------HASERKGTDADCDNIRQVLIYLQFEVR-VYDDLTRKEIKQVLDDL-AEED--HKNSDCLLVVIM X_tropicalis_ENSXETP00000003217 IKDMEK------KTKFAHL-HKYRT--DYPEMGICLIINNKNFQ--SST-------NMGVRNGTDVDARKLHETFTGLGYKVK-VCNDQKSNDIFTLLKKM-SEED--HSKRSSFVCAIL O_latipes_ENSORLP00000010095 RMDVDG-------KPSSHS-FRYSL--NFPTIGLCIIINNKNFD--RGT-------GMNQRNGTDIDAASAMKVFSKLGYRVK-IYNDQTVKQIKQLLTDV-SRMD--HSDSASFVCILL T_rubripes_ENSTRUP00000024164 -------------FFYLQD-EQYEL--LSQPTGLCVIINNENFL------------DMKQRSGTNKDAQSLAEVFTWLGFRVL-MCKDQTKEKMDRALNCFASLVD--PKHGDAFICCIL O_anatinus_ENSOANP00000006351 ----------------QNG-DFYKM--NSNPRGYCLIINNYNFQ--QARAEVPKLKKMKNRDGTDKDAEALSQIFKALAFSPV-VFEDQTAEQILETLQSY-QRMD--HSAQDCFVCCIL M_musculus_ENSMUSP00000030747 DVCV--PGK----IRGHAD-MAYTL--DSDPCGHCLIINNVNFC--PSS-------GLGTRTGSNLDRDKLEHRFRWLRFMVE-VKNDLTAKKMVTALMEM-AHRN--HRALDCFVVVIL D_rerio_ENSDARP00000019984 ESESHY-------RIVSPT-FQYKM--SHQRVGKCIIINNKNFD--EKT-------GMNVRNGTDRDAGELFKCFKSLGFDVA-VYNDQTCRNMERLLKAV-SEED--HSDSSCFACILL G_aculeatus_ENSGACP00000005791 EPPTSQPSD----TNTEVL-GTYPM--TSAKRGICLIVNNFDFT--K-------FKNYQNREGTMKDEERLHKVFAWLGFEVE-VKHDCEGEQMLTALREL-ASRN--HGQADCLVCCVL C_familiaris_ENSCAFP00000016791 QNVTETDAFYK-REMFDPE-EKYKM--DHKRRGIALIFNHERFF--WHL-------TLPDRRGTSADRDNLVRRFSELGFEVK-CFNDLKAEELLLKIHEA-STSS--HIDADCFLCVFL C_intestinalis_ENSCINP00000003204 IYSLPDVTK----MASSEV-ECYQM--DRESRGLALIINNENFH--HAT-------RMNKRSGTDVDARNLSRIFKKLGFDVQ-VYKDLSCISMLEVINEV-STMD--HTGNDCCFVAFL G_aculeatus_ENSGACP00000008661 SSESHY-------RVVSPT-FQYKM--SHQRVGKCIIINNKNFD--EKT-------GMNVRNGTDRDAGELFKCFKSLGFDVF-IYNDQTCGKMESLLREA-SEED--HSDSSCFACILL E_caballus_ENSECAP00000015102 DVRA--QDR----LRGNAD-LAYVL--NADPCGHCLIINNVNFY--LAS-------GLGRRVGSDIDCEKLRQRFSLLHFMVE-VKGDLTAKQMLRALGEL-ARRD--HGALDCCVVVIL B_taurus_ENSBTAP00000003205 DVCP--QDR----AKGNAD-LAYVL--NADPCGHCLIINNVNFC--RES-------GLRARTGSNIDCERMRQRFHLLQFVVE-VKCDLTAKQMVQALMQL-ARQD--HSALDCCVVVIL G_aculeatus_ENSGACP00000007379 NTLTRPPGR----TRRDSI-QSYKM--DASPCGHCLIINNVEFE--PDS-------ELSNRKGSNIDCDKLEKRFKALNFIVE-VRTNLKQRQIKHALSAL-SKKD--HSQCDCCVVIML C_elegans_C48D1.2 EEDMNFVDAPTISRVFDEK-TMYRN--FSSPRGMCLIINNEHFE------------QMPTRNGTKADKDNLTNLFRCMGYTVI-CKDNLTGRGMLLTIRDF-AKHE---SHGDSAILVIL A_gambiae_AGAP009832-PA ANGIIRPAY----VIERYA-AYYPM--NHKRRGMALIFSHNKYN--VRNV------SLPVREGSAIDCKRLKETLELFRFDVK-VYPDFKLEEIKSVIGKV-SSMD--HSDSDCFLVAIL D_rerio_ENSDARP00000093958 ------------------------M--KHAKRGLALIFNQKDFS--LL--------GLKTRKGTDKDRDSLVSRFEELDFEVK-AYNDYSRDKVLKEIKEV-AAAD--HVDADCFVCIFL C_familiaris_ENSCAFP00000032442 -----------------------------------------------------------------------------------------------------------------------M G_gallus_ENSGALP00000002083 RMPPAPAQACPTGLAGECS-EVYQL--RADPCGHCLIFNNVSFS--RDS-------DLSTRAGSDIDCEKLEKRFRSLCFHVR-TLRNLKAQEIDVELRKL-ARLD--HSALDCCLVVIL A_gambiae_AGAP012544-PA HSSLEAMDS----TLQLTL-HSYNM--AHPKRGIAVVINNN-----------------RDRKGSEKDVKALQAVLSHLQFDVR-LLSDKTTVEIRHALKEV-SKED--HTNNDCLAIIAM D_rerio_ENSDARP00000075318 TPSQLSETTGCSTDKTNTM-NEYEM--KSNPRGLCLIFNNENFK-----------DPDMKRHGSQMDTASLKDLFEWLGFSVE-IKQDQTVSAMKRTLKEY--SED--RKHGDCFVCCVL R_norvegicus_ENSRNOP00000017972 DVCT--PGK----IERHAD-MAYTL--DSDPCGHCLIINNVNFC--PSS-------GLSTRIGSHVDCEKLQHRFCWLRFMVE-VKNDLTAKKMVTALMEM-AHRD--HRALDCFVVVIL H_sapiens_ENSP00000286186 -MQGASANTLNSETSTKRA-AVYRM--NRNHRGLCVIVNNHSFT------------SLKDRQGTHKDAEILSHVFQWLGFTVH-IHNNVTKVEMEMVLQKQKCNPA--HADGDCFVFCIL P_pygmaeus_ENSPPYP00000014602 -MQGASANTLNSETGTKGR-KGYRM--NRNHRGLCL-LNNHSFT------------SLKDRRGTHKDAEILSHVFQWLGFTVH-IHNNVTKGEMEEVLQEQKCNPA--HADGDCFVFCIL P_pygmaeus_ENSPPYP00000014606 ----------------TLD-KVYQM--KSKPRGYCLIINNHNFA--KAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIK-PHNDCTVEQIYEILKIY-QLMD--HSNMDCFICCIL A_aegypti_AAEL014348-PA MIPTVAPAY----TIERYS-AYYPM--NHKHRGKAIIFAHSVFA--VKNV------NLPNRDGSDVDCEMLVESLKRLHFDVT-LYKDYRLKDILLVIEKV-SLMD--HSNSDCLLVAVL M_musculus_ENSMUSP00000029626 --MTETDGFYKSREVFDPA-EQYKM--DHKRRGVALIFNHERFF--WHL-------TLPERRGTNADRDNLTRRFSDLGFEVK-CFNDLRAEELLLKIHEV-STSS--HIDADCFICVFL O_latipes_ENSORLP00000003208 HLTRCSRGQ----RSDHDG-TASRM--DARPCGLCLIINNVEFE--PKT-------ELSIRKGSNVDCDKLEKRFKSLNFVVE-VRTNLKQRQIKSELSAL-SRKD--HSIYDCCVVVIL D_melanogaster_FBpp0071971 PANKFVARM----PVERYA-SEYNM--SHKHRGVALIFNHEFFD--IP--------SLKSRTGTNVDAQELKKAFENLGFAVS-VHKDCKLRDILKHVGKA-AELD--HTDNDCLAVAIL O_anatinus_ENSOANP00000002508 PLPVRN-------RVVSSS-FIYNM--KYENLGKCIIINNKNFA--SKT-------GMSTRNGTDKDAGNLQKCFRSLGFDVS-VFNDFSCNQMKEILQKA-SEEN--HENSACFACILL M_mulatta_ENSMMUP00000037892 ----------------TLD-KVYQM--KSKPRGYCLIINNYDFT--KAREKVPKLHSIRDRNGTHLDAEALTATFEELHFEIQ-HHNDCTVEKIYKILKTY-QLMD--HSNKDCFICCIL T_rubripes_ENSTRUP00000044662 TLQVGCPDV----S-VQGV-ETYLM--TAAKRGRCLIINNCNFR--VS--------RLKKREGTMVDEASLDKVLKWLGFEVE-IQRDCTSKKMSSLIQEL-AKTS--QRDWDCVMCCVL D_rerio_ENSDARP00000075650 ENFPMLKDHDIFDSSVQEI-SPYRI--IKNPRGICVIINNEIFS-----------SGMMSRRGSDKDREYLAKVFHWLGFEVV-EHNNKDTAEIRNILKDL-GRTV----DGDCFVCCIL E_caballus_ENSECAP00000013268 QNMTEIDAFYK-REMFDPA-EKYKM--DHKRRGIALIFNHERFF--WHL-------TLPDRRGTSADRDNLMRRFSDLGFEVK-CFNDLKAEELLLKIYEV-STSS--HADADCFVCVFL X_tropicalis_ENSXETP00000035938 QASDNV-------RIVTPA-FQYKM--NYGKVGRCIIINNKNFD--DIT-------GMSPRNGTDIDARDLLRCFKGLGFDVT-VFNNKSCTEMETLLRSV-AEQD--HKDSACFACIFL A_aegypti_AAEL011562-PA VRSLYKVELSARPQSHRIL-EAYEM--RRRNRGVVFIVNVITYI--NE--------THPTRNGAEADKYNLVSLFQQLGFTVF-YYEDLTSDEFNNLIKEL-KQSS--YLSTECFVFYIL E_caballus_ENSECAP00000004055 ----------------TSD-KVYRM--ESKPRGYCLIFNNHDFS--AARRDVPKLQNIKDRNGTDLDAEALSMTFTELHFEVV-PYKNSTAKDICDALREY-QEMD--HKKKDCFICCIL 610 620 630 640 650 660 670 680 690 700 710 720 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000221740 AHG-RE-------GF-LKGE-------DGEMVKLENLFEALNNKNCQALRAKPKVYIIQ--ACRG-------------EQR-DPGE---TVGGD------------------EIV----- M_mulatta_ENSMMUP00000024183 AHG-RE-------GF-LKGE-------DGEMVKLDNLFEALNNKNCQALRAKPKVYIIQ--ACRG-------------EQK-DPGE---TVGGD------------------EIV----- C_familiaris_ENSCAFP00000023821 AHG-LE-------GR-LKGE-------DGEMVELEDLFKVLNNKNCRALRAKPKVYIVQ--ACRG-------------EQR-DPGE---TVSGD------------------DIV----- E_caballus_ENSECAP00000010379 AHG-VE-------GR-LKGE-------DEQMVELESLFEVLNNKNCQALKARPKVYIVQ--ACRG-------------EQR-DPGE---TVGSD------------------DIM----- B_taurus_ENSBTAP00000028116 AHG-LE-------GR-LKGK-------DEKMVELEDLFQALNNKNCRALRAKPKVYIVQ--ACRG-------------EQR-DPGE---PVTGG------------------HLV----- O_cuniculus_ENSOCUP00000002346 AHG-DE-------GV-LKGE-------DEEMVKLEDLFEVLNNKNCKALRAKPKVYIVQ--ACRG-------------EHR-DLGE---TVGED------------------QVM----- R_norvegicus_ENSRNOP00000009643 AHG-EE-------GF-LKGE-------DGNMVRLEDLFEVLNNKNCKALRGKPKVYIIQ--ACRG-------------EHR-DPGE---ELPGD------------------ELA----- P_pygmaeus_ENSPPYP00000010831 AHG-RE-------GF-LKGE-------DGEMVKLENLFEALNNKNCQALRAKPKVYIIQ--ACRG-------------EQR-DPGE---TVGGD------------------EIV----- M_musculus_ENSMUSP00000005488 AHG-EE-------GL-LKGE-------DEKMVRLEDLFEVLNNKNCKALRGKPKVYIIQ--ACRG-------------EHR-DPGE---ELRGNEELGGDEELGG-------DEV----- G_gorilla_ENSGGOP00000000424 AHG-RE-------GF-LKGE-------DGEMVKLENLFEALNNKNCQALRAKPKVYIIQ--ACRG-------------XXX-XXXX---XXXXX------------------XXX----- M_domestica_ENSMODP00000018104 AHG-EE-------GI-LQGV-------DGNTIRLDELFCMLTNKNCRALRGKPKVFIVQ--ACRG-------------DQK-DPGE---VVKPTSSG---------------GDV----- O_anatinus_ENSOANP00000013840 AHG-KE-------GH-LLGA-------DEQVVELEELYDVLTNKSCRALLGKPKVFILQ--ACRG-------------DQK-DSGE---MLRTE------------------EVL----- M_domestica_ENSMODP00000020556 AHGEPQ-------GR-LLGA-------DGQMVEVEEMVSELS--ACQVLQGKAKVVLLQ--GCRG-------------GNR-DPGM-----RPRALPWLG------------SWL----- E_caballus_ENSECAP00000006138 AHGGPQ-------GQ-LLGA-------DGQEVQPEALVRELS--CCRALRGRPKIFLLQ--ACRG-------------GHR-DAGL-----GPTAL----------------SWF----- M_mulatta_ENSMMUP00000027593 AHGGPQ-------GQ-LLGA-------DRQEVQPEALMQELS--RCRVLWGRPKVFLLQ--ACRG-------------GNR-DAGV-----GPTAL----------------PWY----- B_taurus_ENSBTAP00000045524 AHGGPQ-------GQ-LLGA-------DGQERQLEVLVQELS--HCGALRGRPKIFLLQ--ACRG-------------GEQ-APGP---PWRPASCCPSSPHPALSLSGLVVHLL----- B_taurus_ENSBTAP00000012869 SHG-EE-------GF-IKMK-------DGEKVSLEDIFEMFNNKNCPALQEKPKIFIIQ--ACRG-------------ERR-DSGV-----ETDDE----------------PMD----- M_domestica_ENSMODP00000032734 AHG-GK-------GH-IKTK-------SNERVNLSDIFEMFNNENCPALQEKPKIFVIQ--ACRG-------------DKR-DGGV----VQADDE----------------PM------ C_familiaris_ENSCAFP00000007585 SHG-EN-------GF-IKME-------DGEKVNLQDIFEMFNNKNCPALQEKPKIFIIQ--ACRG--------VLQNTERR-DSGV-----ETDDE----------------PME----- O_cuniculus_ENSOCUP00000000197 AHGGPQ-------GQ-LLGA-------DGQEVQPEALVQELN--PCGALSGCPKVFLLQ--AWRG-------------GNR-DAGK-----GPKAL----------------PWY----- A_carolinensis_ENSACAP00000013788 SHGKAN-------GY-ILDK-------DNREISLDGIFSLFNNKTCPKLQGKPKIFIIQ--ACRG-------------EQR-DYGT----LVAGGK----------------PV------ O_anatinus_ENSOANP00000019254 SHG-VN-------GF-IKGK-------DEKVVDLEEIFKLFNNANCPNLREKPKIFIIQ--ACRGGPNHRSRGIKSKIDRT-DGGV----EAFDNV----------------PEE----- E_caballus_ENSECAP00000017996 SHG-EN-------GF-IKMK-------DDERVSLEDIFEMFNNKNCPALQEKPKIFIIQ--ACRG-------------EKR-DSGV-----ETDDE----------------PMD----- T_guttata_ENSTGUP00000006879 SHG-DE-------GL-IYGT-------DG-PLELKALTSLFRGDRCRSLAGKPKFFFIQ--ACRG-------------TEL-DSGI-----ETD-S-----GS----------------- A_carolinensis_ENSACAP00000006831 SHG-IE-------GG-IYGI-------DGKLLQLQEIFRLFDNANCPNLQNKPKMFFVQ--ACRG-------------DET-DHGV----DQIDGNDRASSPGCE-E-----TDA----- O_anatinus_ENSOANP00000000517 SHG-EE-------GV-IFGT-------DG-SLELKSLASLFRGDNCRSLVGKPKLFIVQ--ACRG-------------TEL-DSGV-----EAD-S-----SS----------------- T_guttata_ENSTGUP00000013612 SHG-VE-------GG-VYGS-------DGKLLELQETFRLFDNANCPNLQNKPKMFFIQ--ACRG-------------DEL-DRGV----DQRDGKGRSDSPGCE-E-----SDA----- M_domestica_ENSMODP00000005556 SHG-EE-------GV-IFGT-------DR-SVELKRLTCFFRGDKCRSLTGKPKLFIIQ--ACRG-------------TEL-DCGV-----ETD-S-----GT----------------- G_gallus_ENSGALP00000029853 SHG-VE-------GG-VYGT-------DGKLLQLQEAFRLFDNANCPNLQNKPKMFFIQ--ACRG-------------DET-DRGV----DQRDGKEWSDSPGCE-E-----SDA----- A_carolinensis_ENSACAP00000009923 SHG-EE-------GL-IYGT-------DG-CMAIKNLTGLFRGDKCQSLIGKPKLFFIQ--ACRG-------------SEF-DAGI-----QTD-S-----GSSN-DNL----------- G_gallus_ENSGALP00000017288 SHG-DE-------GL-FYGT-------DG-PLELKVLTSLFRGDKCRSLAGKPKLFFIQ--ACRG-------------TEL-DSGI-----EAD-S-----GP----------------- X_tropicalis_ENSXETP00000015203 SHG-LD-------GA-VYGT-------DGKLVQLQDVFTAMDNAHCPQLQNKPKMFFIQ--ACRG-------------EEA-DRGV----DQRDGREQSASPGCE-Q-----SDA----- M_domestica_ENSMODP00000001598 SHG-IE-------GG-IYGV-------DGKLLQLQEVFRLFDNANCPNLQNKPKMFFIQ--ACRG-------------DET-DRGV----DLRDGKEHVASPGCE-E-----SDA----- D_rerio_ENSDARP00000024255 SHG-RL-------ND-IIGV-------DGKAVPFKELMETLSPFRCSSLYQKPKLFFIQ--ACRG-------------TQN-QRAV---FPQTF-T-----EDED-VL----A-S----- R_norvegicus_ENSRNOP00000014096 SHG-DE-------GV-IFGT-------NG-PVDLKKLTSFFRGDYCRSLTGKPKLFIIQ--ACRG-------------TEL-DCGI-----ETD-S-----GT----------------- G_aculeatus_ENSGACP00000024809 SRG-DE-------GG-IYGT-------DGSFVNLDELTKFVDGNGCRSLVGKPKLLFIQ--AARG-------------NKL-DDGT-----LSE-G-----DS----------------- M_musculus_ENSMUSP00000031895 SHG-VE-------GG-IYGV-------DGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQ--ACRG-------------DET-DRGV----DQQDGKNHTQSPGCE-E-----SDA----- O_anatinus_ENSOANP00000005545 SHG-VE-------GG-IYGV-------DGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQ--ACRG-------------DET-DRGV----DQRDGKERAASPGCE-E-----SDA----- B_taurus_ENSBTAP00000021099 SHG-EE-------GI-IFGT-------NG-PVNLKKLASFFRGDYCRSLTGKPKLFIIQ--ACRG-------------TEL-DCGI-----ETD-S-----GA----------------- R_norvegicus_ENSRNOP00000022672 SHG-VE-------GG-IYGV-------DGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQ--ACRG-------------DET-DRGV----DQQDGKNHAQSPGCE-E-----SDA----- P_pygmaeus_ENSPPYP00000017020 SHG-EE-------GI-IFGT-------NG-PVDLRKITNFFRGDRCRSLTGKPKLFIIQ--ACRG-------------TEL-DCGI-----ETD-S-----GV----------------- M_musculus_ENSMUSP00000091238 SHG-DE-------GV-IYGT-------NG-PVELKKLTSFFRGDYCRSLTGKPKLFIIQ--ACRG-------------TEL-DCGI-----ETD-S-----GT----------------- O_anatinus_ENSOANP00000015596 SHG-YQASHIQFPGG-IHGT-------DGESISVETIVNYFNGSRCPSLGGKPKLFFIQ--ACGG-------------EKK-DPGF---EVNLDSP-----EDHP-TG----SDPESDAA M_mulatta_ENSMMUP00000016588 SHG-VE-------GA-IYGV-------DGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQ--ACRG-------------DET-DRGV----DQQDGKNHAGSPGCE-E-----SDA----- D_rerio_ENSDARP00000071815 SHG-DD-------GL-IYGT-------DN-SIELKRLFAHFRGDRCTSLVGKPKLFFIQ--ACRG-------------TDL-DSGI-----ECD-G------------------------ D_rerio_ENSDARP00000083664 SHG-VE-------GS-VYGT-------DGQLLELDWVFEVFDNARCPLLQNKPKMFFIQ--ACRG-------------EEM-DNGV----DQLDGQERTQSPGCE-Q-----RDA----- E_caballus_ENSECAP00000003321 SHG-VE-------GG-IYGV-------DGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQ--ACRG-------------DET-DRGV----DQQDGKNHAKSPECE-E-----SDA----- P_troglodytes_ENSPTRP00000054330 SHG-EE-------GI-IFGT-------NG-PVDLKKITNFFRGDRCRSLTGKPKLFIIQ--ACRG-------------TEL-DCGI-----ETD-S-----GV----------------- H_sapiens_ENSP00000311032 SHG-EE-------GI-IFGT-------NG-PVDLKKITNFFRGDRCRSLTGKPKLFIIQ--ACRG-------------TEL-DCGI-----ETD-S-----GV----------------- M_domestica_ENSMODP00000005560 SHG-EE-------GV-IFGT-------DD-SVELKELTYFFKGYKCKSLTGKPKLFIIQ--ACQG-------------REF-DCGV-----ETD-S-----GT----------------- P_pygmaeus_ENSPPYP00000020323 SHG-VE-------GA-IYGV-------DGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQ--ACRG-------------DET-DRGV----DQQDGKNHAGSPGCE-E-----SDA----- H_sapiens_ENSP00000312664 SHG-VE-------GA-IYGV-------DGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQ--ACRG-------------DET-DRGV----DQQDGKNHAGSPGCE-E-----SDA----- P_troglodytes_ENSPTRP00000033921 SHG-VE-------GA-IYGV-------DGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQ--ACRG-------------DET-DRGV----DQQDGKNHAGSPGCE-E-----SDA----- D_rerio_ENSDARP00000006831 SHG-DE-------GV-FFGT-------DT-SVDLKSLTSLFRGDRCPSLVGKPKLFFIQ--ACRG-------------TEL-DPGV-----ETD-H-----PDHP--------------- R_norvegicus_ENSRNOP00000022693 SHG-EE-------NL-IYGK-------DG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACRG-------------TEL-DDGI-----QAD-S-----GPIN-D------------- M_musculus_ENSMUSP00000026062 SHG-EE-------DL-IYGK-------DG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACRG-------------TEL-DDGI-----QAD-S-----GPIN-D------------- M_domestica_ENSMODP00000036247 SHG-NK-------GT-IYGI-------DGKEVPIRDLTSYFSGSNCPSLAGKPKVFFIQ--ACQG-------------KAT-QYGI---SLDTD-S-----EQQR-ES----LEA----- E_caballus_ENSECAP00000019797 SHG-EE-------GI-IFGT-------NG-PIDLKKLTCFFKGDCCRSLAGKPKLFIIQ--ACRG-------------TEL-DSGI-----ETD-S-----GI----------------- G_aculeatus_ENSGACP00000024816 SHG-DE-------GV-IYGT-------DG-FEKLDDLTKFFKGDRCRSLVGKPKLFFIQ--ACRG-------------TEL-DEGS-----QIE-A-----DS----------------- C_intestinalis_ENSCINP00000007986 SHG-DA-------GC-FYGS-------DGVSVAIDTVVNFFSNQNCHSLQKKPKIFLFQ--ACQG-------------DEY-DMGV----DEVDGPVQAPVGDVD-NT----STS----- B_taurus_ENSBTAP00000008706 SHG-EE-------NL-IYGT-------DG-KTAIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACRG-------------TEL-DDGI-----QAD-S-----GPIN-D------------- C_familiaris_ENSCAFP00000032189 SHG-DE-------GI-IFGT-------NG-PVDLRKVTGFFRGDYCRSLTGKPKLFIIQ--ACRG-------------TEL-DCGI-----ETD-S-----GI----------------- D_rerio_ENSDARP00000072390 SHG-EE-------GT-ILGS-------DERWIPVKTLTSLLTSDLCPSLRDKPKIFFLQ--ACRG-------------VEY-DPGV-----EAD-S-----VEAS--------------- B_taurus_ENSBTAP00000038128 THG-NK-------GI-IYGS-------DGQEASIYELTSYFTGLKCPSLIGKPKIFFIQ--ACQG-------------DKY-QKGV---AVETD-S-----EQME-AY----LEV----- G_aculeatus_ENSGACP00000016983 SHG-RK-------GV-VLGI-------DDQPLSIKQIIGTFLPPANTTLTGKPKVFLIQ--ACQG-------------GQA-QHGV---FEEL--------------------------- G_gallus_ENSGALP00000013506 SHG-ES-------GA-VYGK-------DGKLVSIRTIMTYFTAKQCPQLTEKPKLFFVQ--ACQG-------------KEV-QRPV---YVETD-A-----RVPDFSSV----------- A_gambiae_AGAP000830-PA SHG-EL-------GY-LYAK-------DC-QYKLDTIWTYFTANHCPSLAGKPKLFFIQ--ACQG-------------DQL-DGGV-----VLE-A-----KDRTETD------------ T_guttata_ENSTGUP00000010625 SHG-KK-------GI-IYGV-------DGQEVPIRELTTSFTAQNCSSLAGKPKVFFIQ--ACQG-------------DAF-HKGV---AIETD-S-----VEED-SS----LER----- G_aculeatus_ENSGACP00000013740 SHG-VE-------GA-IYGT-------DGQLLKLDWVFESFDNAHCPLLQNKPKMFFIQ--ACRG-------------EEM-DCGV----EQIDGPVRTCSPSCE-Q-----RDA----- M_mulatta_ENSMMUP00000015808 SHG-EE-------GI-IFGT-------NG-PLDLKKITSFFRGDCCRSLTGKPKLFIIQ--ACRG-------------TEL-DCGI-----ETD-S-----GV----------------- G_gallus_ENSGALP00000013571 SHG-EK-------GK-IKGV-------DNELVNIKDLLSCFSGSNCPSLAGKPKLFFIQ--ACQG-------------SVG-HPAV---TVKED-C-----SGHL--------------- G_gallus_ENSGALP00000014503 SHG-EE-------GL-IYGT-------DG-PMAIKHLTTLFRGDKCKTLIGKPKLFFIQ--ACRG-------------SEF-DEGI-----QTD-S-----GPAN-DTL----------- A_gambiae_AGAP011951-PA THGKEN-------NL-LYAS-------DK-SYEANQLWEPFIGDACPSLIGKPKLFFVQ--ACRG-------------KKL-DEGVIQATISID-S-----VDTQ--------------- P_pygmaeus_ENSPPYP00000003106 SHG-EE-------NL-IYGK-------DG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACRG-------------TEL-DDGI-----QAD-S-----GPIN-D------------- O_latipes_ENSORLP00000015114 SHG-VD-------GA-IYGT-------DGQQLALDWVFEAFDNAHCPLLQNKPKMFFIQ--ACRG-------------DEM-DCGV----EQIDGPARTFSPTCE-Q-----RDA----- C_familiaris_ENSCAFP00000016420 SHG-EE-------NL-IYGT-------DG-MTAIKDLTAHFRGDRCRTLLEKPKLFFIQ--ACRG-------------TEL-DDGV-----QAD-S-----GPIN-D------------- P_troglodytes_ENSPTRP00000005216 SHG-EE-------NV-IYGK-------DG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACRG-------------TEL-DDGI-----QAD-S-----GPIN-D------------- T_nigroviridis_ENSTNIP00000009934 SHG-DE-------GV-LYGT-------DG-PMEIKSLTSLFRGDRCRSLVGKPKLFFIQ--ACRG-------------NDL-DGGI-----ETD-S------------------------ G_aculeatus_ENSGACP00000024812 SHG-DE-------DG-IYGT-------DG--TSLDDLTKFFKGDRCRSLVGKPKLFFIQ--ACRG-------------TDT-DRGV-----NFD-A-----DS----------------- O_latipes_ENSORLP00000010793 SHG-EE-------GV-IYGT-------DG-PVSFNKLIECLKGRSCLSLVGKPKLFFIQ--ACRG-------------TLF-DEGI-----EHD-A------------------------ B_taurus_ENSBTAP00000024166 SHG-VE-------GG-VYGV-------DGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQ--ACRG-------------DET-DRGV----DLQDGKNHDRSPKCE-E-----SDA----- G_gorilla_ENSGGOP00000007184 SHG-EE-------NV-IYGK-------DG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACRG-------------TEL-DDGI-----QAD-S-----GPIN-D------------- T_rubripes_ENSTRUP00000045375 SHG-TEVSHSRFPGA-VYGV-------DGQFVPVQHITTYLNGQHCPSLQGKPKLFFIQ--ACGG-------------DEK-DTGF---EVSPDEF-----EPPV-VS----AHDQTDAI G_gallus_ENSGALP00000013591 SHG-KK-------GI-IYGV-------DGQEVPIQELTTSFTGQNCQSLAGKPKVFFVQ--ACQG-------------DAY-QKGV---TIETD-S-----GEQD-YS----LET----- T_nigroviridis_ENSTNIP00000013855 SHG-TEVSHSRFPGA-VYGV-------DGQFVPVQHIATYLNGQYCPSLQGKPKLFFIQ--ACGG-------------DEK-DTGF---QVSPDEF-----EPPV-VG----ADDQTDAI A_carolinensis_ENSACAP00000002670 SHG-ED-------GL-IYGT-------DG-HVELKMLTSFFRGDKCKSLAGKPKLFFIQ--ACRG-------------TEL-DSGI-----ETD-S-----AS----------------- A_aegypti_AAEL003444-PA SHG-EQ-------GV-LYAR-------DN-KYNVDSLWKNFVGNACPSLIGKPKMFFIQ--ACRG-------------EQF-DEGVAYAAKSPKDM-----VD----------------- O_cuniculus_ENSOCUP00000009498 SHG-EE-------NL-IYGK-------DG-VIPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACRG-------------TEL-DDGI-----QAD-S-----GPIN-D------------- T_guttata_ENSTGUP00000011206 SHG-EE-------GL-IYGT-------DG-PMAIKSLTALFRGDKCKSLIGKPKLFFIQ--ACRG-------------SEF-DEGI-----QTD-S-----GPAN-DTL----------- A_gambiae_AGAP004921-PA THG-DD-------DV-LYAY-------DG-PYSVDKLWESFMGNACTTLLGKPKLFFVQ--ACRG-------------STF-DKGVKLGCRDLD-S------------------------ H_sapiens_ENSP00000358327 SHG-EE-------NV-IYGK-------DG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACRG-------------TEL-DDGI-----QAD-S-----GPIN-D------------- A_carolinensis_ENSACAP00000001629 SHG-ES-------GK-IYGT-------DGNLIPIRTIMSYFTAKQCPQLAKKPKLFFIQ--ACQG-------------EKT-QQPV---YLETD-D-----EYGS--------------- D_rerio_ENSDARP00000063081 SHG-VE-------EG-VCGT-------DGSLVSVDEIRNPFTGVNCQKLVGKPKLFFIQ--ACRG-------------QRK-QLRV---NAQADGPGDGESEME---------------- X_tropicalis_ENSXETP00000008971 THG-ES-------GT-VMGS-------DDKEVSIREIMSYFTAISCTSLVLKPKLFFIQ--ACQG-------------KFT-HPSS---KVEAD-A-----IVPE--------------- T_guttata_ENSTGUP00000017449 SHG-CQTSHIQFPGG-VYGT-------DGKPIPIEKIVNYFNGSSCPSLRGKPKLFFIQ--ACGG-------------EQR-DQGF---VVDCDSP-----KEEA-LG----DSLESDAI T_rubripes_ENSTRUP00000037606 SHG-VE-------GA-VYGI-------DGELLQLDWVFEAFDNAHCPLLQNKPKMFFIQ--ACRG-------------DEM-DCGV----EQIDGPSRTSSPSCE-Q-----RDA----- E_caballus_ENSECAP00000013731 SHG-EE-------NL-IYGT-------DG-MTPIKDLTGHFRGDRCKTLLEKPKLFFIQ--ACRG-------------TEL-DDGI-----QAD-S-----GPINDD------------- C_familiaris_ENSCAFP00000005409 SHG-VE-------GG-IYGV-------DGKLLQLQEVFRLFDNASCPNLQNKPKMFFIQ--ACRG-------------DET-DRGV----DQQDGKNHTGSSECE-E-----SDA----- D_rerio_ENSDARP00000034228 SHG-KR-------DA-IMGVHYHRTNNPSDSFPVDNVYRRLNSENCPALRDKPKVILIQ--ACRG-------------GEH-GRVW-----ASDGE----------------PDE----- T_nigroviridis_ENSTNIP00000022078 SHG-EE-------GM-IYGT-------DG-AMPIKTMTSMFRGDMCKSLVGKPKLFFIQ--ACRG-------------SEF-DDGI-----QTD-S-----GPPN-DTM----------- D_melanogaster_FBpp0084848 SHG-EM-------GY-IYAK-------DT-QYKLDNIWSFFTANHCPSLAGKPKLFFIQ--ACQG-------------DRL-DGGV-----TMQ-------RSQT-ET------------ M_mulatta_ENSMMUP00000001627 SHG-EE-------NL-IYGK-------DG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACRG-------------TEL-DDGI-----QAD-S-----GPIN-D------------- T_rubripes_ENSTRUP00000040691 SHG-DE-------GV-FFGT-------DG-SVELKYLTSLFRGDRCKSLVGKPKLFFIQ--ACRG-------------NDL-DGGI-----ETD-S------------------------ A_gambiae_AGAP011950-PA AHG-NN-------DK-ITLR-------RG-EMHIDELWTDFVGNGCPSLIGKPKLVFIQ--SCRG-------------NKH-DYLV-----GGA-------AVDA-VP------------ D_rerio_ENSDARP00000047019 SHG-TEASHNRFPGA-VHGV-------DGPAVPIQIITNYLNGQNCPSLQGKPKLFFIQ--ACGG-------------GEK-DIGF---EVSPDDV-----QPSI-GG----IDDEMDAI C_familiaris_ENSCAFP00000023986 SHG-CEASHRQFPGA-VYGT-------DGCPVSIEKIVNIFNGTGCPSLGGKPKLFFIQ--ACGG-------------EQK-DHGF---AVASASP-----EDRS-PG----SDSEPDAV T_rubripes_ENSTRUP00000031759 SHG-EE-------GM-IYGT-------DG-AMPIKTMTSMFRGDMCKSLVGKPKLFFIQ--ACRG-------------SEF-DDGI-----QTD-S-----GPPN-DTM----------- C_intestinalis_ENSCINP00000024485 SHG-LS-------GC-VYGV-------DGLSLSTSKISKSFRPGMCSSLTGKPKIFFFQ--ACQG-------------DRT-MDGH---SAPVD-D-----VESD--------------- A_gambiae_AGAP011952-PA THG-QD-------GS-LYAA-------DK-QYQIAELWEPFVGDACKTLIGKPKLFFVQ--ACRG-------------TKF-DKGVKLTKIATD-T-----VDAL--------------- C_familiaris_ENSCAFP00000017899 SHG-DK-------GI-IYGS-------DGQEAPIYELTSYFTGSKCPSLAGKPKIFFIQ--ACQG-------------DKY-QKGI---AVETD-S-----EQKE-AY----LEM----- A_gambiae_AGAP011949-PA AHG-KK-------DH-ITLK-------KE-KLRIDKLWASFVGNKCPSLIGKPKLVFIQ--TCRG-------------DNV-DFGV-----ASH-------ETDS-TP------------ G_aculeatus_ENSGACP00000022402 SHG-DG-------DL-FFGT-------DG-PVPLKSLTSLYRGDRCKSLVGKPKLFFIQ--ACRG-------------TEL-DPGI-----EAD-S------------------------ T_nigroviridis_ENSTNIP00000001216 SHG-LE-------GC-VHGV-------DGDQVSIKKLIEPFLGTNCPAMAGKPKLFFIQ--ACQG-------------KKQ-QGVV---HLESD-G-----AEHS-DV----D-T----- A_gambiae_AGAP004920-PA THG-DD-------DV-LHAK-------DG-TFNVDRLWENFIGDSCPSLLGKPKLFFIQ--ACRG-------------SSF-DTGVHFSQCMTQVAKTVVPYAMRELPQPSIVPG----- X_tropicalis_ENSXETP00000003217 SHG-ED-------GL-VYGV-------DG-PIQIKNLTDLFRGDRCKTLVGKPKLFFIQ--ACRG-------------TDL-DSGI-----ETD-S-----GS----------------- O_latipes_ENSORLP00000010095 SHG-DE-------GV-FFGT-------DG-SIELKTLTSLFRGDHCKSLVGKPKLFFIQ--ACRG-------------TEL-DDGI-----EAD-S------------------------ T_rubripes_ENSTRUP00000024164 SHG-EK-------SA-VLGI-------DGEPLCIKQIIRTFKATRQSALVSKPKMFLIQ--ACQG-------------KGT-HRGV---LLKDL-------------------------- O_anatinus_ENSOANP00000006351 SHG-DR-------GV-VYGT-------DGQQASIRSLTSYFTGSRCPTLAGKPKLFFIQ--ACQG-------------DAY-HLAV---ALETD-NGTDKGTAAA-SP----AEP----- M_musculus_ENSMUSP00000030747 SHG-CQASHLQFPGA-VYGT-------DGCSVSIEKIVNIFNGSGCPSLGGKPKLFFIQ--ACGG-------------EQK-DHGF---EVACTSS-----QGRT-LD----SDSEPDAV D_rerio_ENSDARP00000019984 SHG-EE-------GM-IYGT-------DG-AMPIKTMTSLFKGDVCKSLVGKPKLFFIQ--ACRG-------------SEF-DDGV-----QTD-S-----GPPN-DTI----------- G_aculeatus_ENSGACP00000005791 SHG-DE-------GC-VYGV-------DGHTVAIKELKEPFNGLNCASLAGKPKLFFIQ--ACQG-------------TGE-QKAV---NVVPD-G-----PEDS-AV----C-S----- C_familiaris_ENSCAFP00000016791 SHG-EG-------NH-IYAY-------DA-KIEIQTLTGLFKGDKCQSLVGKPKIFIIQ--ACRG-------------DQH-DVPV----LPLD-V-----VDHR-TDKLEDNVT----- C_intestinalis_ENSCINP00000003204 SHG-DD-------GC-VYGT-------DG-IVQIKKIVDQFRGDVCPSLAGKPKIFLFQ--ACRG-------------TLH-ETSV---QLSVD-VVDGEDQPCV--------------- G_aculeatus_ENSGACP00000008661 SHG-EE-------GM-IYGT-------DA-AMPIKSMTSLFRGDMCKSLVGKPKLFFIQ--ACRG-------------SEF-DDGI-----QTD-S-----GPPN-DTL----------- E_caballus_ENSECAP00000015102 SHG-CQASHLQFPGA-VYGT-------DGCPVSIESIVNIFNGTGCPSLGGKPKLFFIQ--ACGG-------------EQK-DPGC---KVDSTSP-----EDRT-PG----SDSEPDAV B_taurus_ENSBTAP00000003205 SHG-CQASHLQFPGA-VYGT-------DGCPVSVERIVNTFNGTGCPSLRGKPKLFFIQ--ACGG-------------EQK-DHGF---EVESTSP-----EDKT-PS----SDPEADAT G_aculeatus_ENSGACP00000007379 SHG-TEVSHNRFPGA-VYGV-------DGQHVPVQLITNYLNGQHCPSLQGKPKLFFIQ--ACGG-------------GER-DTGF---EVSPDEV-----EPSI-GG----ADDQTDAI C_elegans_C48D1.2 SHG-EE-------NV-IIGV-------DDIPISTHEIYDLLNAANAPRLANKPKIVFVQ--ACRG-------------ERR-DNGF-PVLDSVDGVPAFLRRGWD-NR----DGPLFNFL A_gambiae_AGAP009832-PA THG-ED-------GGIVYAY-------DQ-PYELSLIWSFFTADNCPSLAGRPKIFVVQ--ACRG-------------NQL-DHGV-----KV--------------------------- D_rerio_ENSDARP00000093958 SHG-ED-------GH-VYAN-------DE-KIKIPEITDLFKGDKCRGLVGKPKIFIWQNKACRG-------------DKK-DDPV-----APMSA-----EDSDDEM------------ C_familiaris_ENSCAFP00000032442 AHGGPQ-------GQ-LLGA-------DGQEVQPEALVQELN--RCRALWGCPKIFLLQ--ACRG-------------GHR-DAGV-----GPTAL----------------SWF----- G_gallus_ENSGALP00000002083 SHG-CQTSHIQFPGG-IYGT-------DGKIIPIERIVNYFNGSQCPSLRGKPKLFFIQ--ACGG-------------EQK-DQGF---EVDCESP-----QDET-CR----RSIESDAI A_gambiae_AGAP012544-PA AHG-YN-------DR-IKFD-------DD-YLHIDELWTNFVGNKCPSLIGKPKLVFIQ--SCRG-------------GKL-DYGA-----SIA-------TADA-RP------------ D_rerio_ENSDARP00000075318 SHG-NE-------SG-VLGS-------DEKICPVDDITSPFNGANCSSLAGKPKVFFIQ--ACRG-------------HEI-QSKV---MVADGSG-----GSRT--------------- R_norvegicus_ENSRNOP00000017972 SHG-CQASHLQFPGA-VYGT-------DGCSVSIERIVNIFNGTGCPSLGGKPKLFFIQ--ACGG-------------EQK-DHGF---EVAFTSS-----QDKA-FD----SDSEPDAV H_sapiens_ENSP00000286186 THG-RF-------GA-VYSS-------DEALIPIREIMSHFTALQCPRLAEKPKLFFIQ--ACQG-------------EEI-QPSV---SIEAD-A-----LNPE--------------- P_pygmaeus_ENSPPYP00000014602 THG-KF-------GA-VYSS-------DEALIPIREIMSHFTALQCPRLAEKPKLFFIQ--ACQG-------------EEI-QPSV---SIEAD-A-----LNPE--------------- P_pygmaeus_ENSPPYP00000014606 SHG-DK-------GI-IYGT-------DGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQ--ACQG-------------DNY-QKGI---PVETD-S-----EG-Q-PY----LEM----- A_aegypti_AAEL014348-PA SHG-DE-------GEVIYAH-------DC-PYQISSIWTQFTGDRCRTLVGKPKIFIIQ--ACRG-------------NDL-DSGV-----KVE-------------------------- M_musculus_ENSMUSP00000029626 SHG-EG-------NH-VYAY-------DA-KIEIQTLTGLFKGDKCQSLVGKPKIFIIQ--ACRG-------------SQH-DVPV----VPLD-M-----VDHQ-TDKLD-NVT----- O_latipes_ENSORLP00000003208 SHG-TEVSHNRFPGA-VYGV-------DGNHVSVQEITNYLNGQNCPSLQSKPKIFFIQ--ACGG-------------GEK-DIGF---EVSPDEA-----KPSI-GG----DGDQTDAI D_melanogaster_FBpp0071971 SHG-EH-------GY-LYAK-------DT-QYKLDNIWHYFTATFCPSLAGKPKLFFIQ--ACQG-------------DRL-DGGI-----TLE-------KGVT-ET------------ O_anatinus_ENSOANP00000002508 SHG-EG-------DC-IYGT-------DD-FIPIKELTILFRGDKCKSLLGKPKLFFIQ--SCRG-------------TEF-DDGI-----QTD-S-----TPVT-D------------- M_mulatta_ENSMMUP00000037892 SHG-DK-------GI-IYGT-------DGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQ--ACQG-------------DNY-QKGI---PVETD-S-----EE-Q-PY----LEM----- T_rubripes_ENSTRUP00000044662 SHG-LE-------GG-VYGV-------DGGTVEIRKLMEPFSGTNCPSLAGKPKIFFIQ--ACQG-------------SRQ-QDIV---YTDAG-T-----PGHG-YV----D-N----- D_rerio_ENSDARP00000075650 SHG-RR-------EG-VCGT-------DGNYLSIDEIRDPFTGVKCQKLVGKPKLFFIQ--GCRG-------------ANSLQACV---KVEADAG---NSKAK---------------- E_caballus_ENSECAP00000013268 SHG-EG-------NH-IYAY-------DA-KIEIQTLTGLFKGDKCQSLVGKPKIFIIQ--ACRG-------------DQH-DVPV----TPLD-V-----VDHG-TDKLDANVT----- X_tropicalis_ENSXETP00000035938 SHG-EE-------GL-IYGT-------DG-AMPIKVLTTLFRGDKCRSLVGKPKLFFIQ--ACRG-------------CEF-DDGL-----ETD-A-----GPSN-DSL----------- A_aegypti_AAEL011562-PA AHG-NH---TKGRDK-IYLN-------DNSVLYVEDVLALFNNANCPKLIRRPKLFFFS--ICRG-------------DNP-DYGTLRLAEHTERD----------------GMI----- E_caballus_ENSECAP00000004055 SHG-DK-------GI-IYGC-------DGQEASIYELTSYFTGSNCPSLAGKPKIFFIQ--ACQG-------------DNY-QKGI---AVETD-S-----ELTD-AY----LEM----- 730 740 750 760 770 780 790 800 810 820 830 840 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000221740 ------------MVIKD--------------SP-QTIPTYTDALHVYSTVE--GY-------------------------IAYRHDQKGSCFIQTLVDVFTK-----------RKGHILE M_mulatta_ENSMMUP00000024183 ------------MVTKD--------------SP-QTIPTYTDALHVYSTVE--GY-------------------------IAYRHDQKGSCFIQTLVDVFTK-----------GKGHILE C_familiaris_ENSCAFP00000023821 ------------MITKD--------------NP-QTIPTYTDILHVYSTVE--GY-------------------------IAYRHDKEGSCFIQTLVDVFTE-----------RKGPILE E_caballus_ENSECAP00000010379 ------------MIAKD--------------SP-ETIPTYTDTLHIYSTVE--GY-------------------------IAYRHDKEGSCFIQTLVDVFTE-----------RRGPILE B_taurus_ENSBTAP00000028116 ------------MITEN--------------TP-ETIPTYTDTLHVFSTIE--GY-------------------------IAYRHDQEGSYFIQTLVDVFIN-----------KKGPILE O_cuniculus_ENSOCUP00000002346 ------------MITRD--------------SP-QTIPTYTDTLHVYSTVE--GY-------------------------IAYRHDQEGSCFIQTLTDVFMN-----------RTGPILE R_norvegicus_ENSRNOP00000009643 ------------VIKKK--------------NP-PTIPTYTDMIHIYSTVE--GF-------------------------LSYRHDQKGSGFIQTLTDVFIH-----------KKGSITE P_pygmaeus_ENSPPYP00000010831 ------------MVIKD--------------SP-QTIPTYTDALHVYSTVE--GY-------------------------IAYRHDQK-------------------------------- M_musculus_ENSMUSP00000005488 ------------AVLKN--------------NP-QSIPTYTDTLHIYSTVE--GY-------------------------LSYRHDEKGSGFIQTLTDVFIH-----------KKGSILE G_gorilla_ENSGGOP00000000424 ------------XXXXX--------------XX-XXXXXXXXXXXXXXXXX--XY-------------------------IAYRHDQKGSCFIQTLVDVFTK-----------RKGHILE M_domestica_ENSMODP00000018104 ------------LLAKE--------------RP-PKLPTFSDSLHVYATVE--GY-------------------------IAYRHEEDGSFFIQTLVDVFTN-----------MKGNILD O_anatinus_ENSOANP00000013840 ------------TTMIQ--------------KV-PRIPTFTDTLHVYSTVE--GK-------------------------GSHCH----------------------------------- M_domestica_ENSMODP00000020556 ------------QHWLQ--------------RP-STIPSHADILQVYANLQ--GY-------------------------VAYRN-ENGSDFIQTLVQVIIA-------N---PDQDLLE E_caballus_ENSECAP00000006138 ------------WRWLR--------------AP-PATPSHADVLQVYADAQ--GSSSRGPTAGSSDQADILMVYAAAEGCVAYRD-ETGSDFIQTLVEVLRA-------D---PKGDLLE M_mulatta_ENSMMUP00000027593 ------------WSWLR--------------AP-PSVPSHADVLQIYAEAQ--GY-------------------------VAYRD-DKGSDFIQTLVEVLRA-------N---PGRDLLE B_taurus_ENSBTAP00000045524 ------------QRWLR--------------AP-PATPSQADVLHVCTDVQ--GC-------------------------VAYRD-KKGSDFIQTLVEVLRA-------D---PKADLLE B_taurus_ENSBTAP00000012869 ------------LDDGS--------------EK-KRLPTFSDYFIVYPTQA--DH-------------------------VALRDPRTGSVMIKEMTEVFKQ-------YG--NKWHLAD M_domestica_ENSMODP00000032734 ------------ELDLS--------------EK-KRLPTSSDYYIIYATQD--DH-------------------------VAFRHPRDGSVMIQAIDEVFRQ-------HG--KKWHIAD C_familiaris_ENSCAFP00000007585 ------------SDDVS--------------EK-RRLPTFSDYFIIYPTQA--DH-------------------------VALRHPRTGSVMIEAMSEVFKQ-------YG--NKWHIAD O_cuniculus_ENSOCUP00000000197 ------------RRWLW--------------VPQPALPSHADVLQVHADAQ--GSSCSGPAPGSSGQADVLTVYAAAEGCVAYRD-EMGSDFIQTLVDVLRA-------D---PGRDLLE A_carolinensis_ENSACAP00000013788 ------------EPDTW--------------SR-PKLPTVSDYFIVYSSQR--DH-------------------------IAVRDENTGSEMISAMDEVFSE-------HG--TQWHIGD O_anatinus_ENSOANP00000019254 ------------MDDTS--------------NV-KRLPTTSDFFIVYSTQK--GH-------------------------VSVRNPLMGSRMIEAMDDVFSR-------YG--KKWQLTD E_caballus_ENSECAP00000017996 ------------SDDIS--------------EK-RRLPTFSDYFIIYPTQA--DH-------------------------VALRHPRTGSVMIEAMAEVFKQ-------HG--NRWHIAD T_guttata_ENSTGUP00000006879 --------------EET--------------MC-QKIPVEADFLYAYSTAP--GY-------------------------YSWRNSAEGSWFIQSLCKMLKE-------HA--RKLELMQ A_carolinensis_ENSACAP00000006831 ------------NKKEN--------------PK-LRLPTCSDMICGYACLK--GT-------------------------AAMRNTKHGSWYVEALTSVFAE-------DS--GHMHVAD O_anatinus_ENSOANP00000000517 -------------ADDG--------------SE-QKIPVEADFLYAYSTAP--GY-------------------------YSWRNSMNGSWFIQALCAMLKQ-------HA--HTLELLH T_guttata_ENSTGUP00000013612 ------------NKEES--------------LK-LRLPTCSDMICGYACLK--GT-------------------------AAMRNTKRGSWYVEALTSVFAE-------DS--QHTHVAD M_domestica_ENSMODP00000005556 -------------DEDI--------------AC-QKIPVEADFLYAYSTAP--GY-------------------------YSWRNSKDGSWFIQALCAVLKQ-------HA--HKLEIMQ G_gallus_ENSGALP00000029853 ------------NKEEN--------------LK-LRLPTRSDMICGYACLK--GT-------------------------AAMRNTKRGSWYIEALTTVFAE-------DS--RDTHVAD A_carolinensis_ENSACAP00000009923 ------------EMDAN--------------PR-YKIPVEADFLYAYSTVP--GY-------------------------FSWRNPGKGSWFVQSLCSVLND-------HG--KELEVLQ G_gallus_ENSGALP00000017288 --------------DET--------------VC-QKIPVEADFLYAYSTAP--GY-------------------------YSWRNAAEGSWFIQSLCRMLKE-------HA--RKLELMQ X_tropicalis_ENSXETP00000015203 ------------GRED---------------IK-VRLPTQSDMICAYACLK--GT-------------------------VSLRNTKRGSWFVQDLVSVFSQ-------YS--KNTHVAD M_domestica_ENSMODP00000001598 ------------GKEKI--------------LK-MRLPTRSDMICGYACLK--GT-------------------------AAMRNTKRGSWYIEALTQVFSE-------RA--RDMHVAD D_rerio_ENSDARP00000024255 ------------D-AGV--------------PR-DSIPEMADYLMAMSTVP--WY-------------------------ASYRDKSKGTWFIQSLCDNLRL-------LVP-RGNDLLS R_norvegicus_ENSRNOP00000014096 -------------DDDM--------------AC-QKIPVEADFLYAYSTAP--GY-------------------------YSWRNSRDGSWFIQSLCAMLKL-------YA--HKLEFMH G_aculeatus_ENSGACP00000024809 -------------MDGQ--------------TP-SRIPVEADFLYAYSTTP--GF-------------------------NAWRDTQNGSWFMQSLCEMLRR-------FS--GQLELMQ M_musculus_ENSMUSP00000031895 ------------GKEEL--------------MK-MRLPTRSDMICGYACLK--GN-------------------------AAMRNTKRGSWYIEALTQVFSE-------RA--CDMHVAD O_anatinus_ENSOANP00000005545 ------------GKEEM--------------LK-VRLPTRSDMICGYACLK--GT-------------------------AAMRNTKRGSWYIEALTQVFAE-------SA--RDMHVAD B_taurus_ENSBTAP00000021099 -------------EDDM--------------AC-QKIPVEADFLYAYSTAP--GY-------------------------FSWRNAKNGSWFIQALCEMLKK-------HA--HRLELMH R_norvegicus_ENSRNOP00000022672 ------------GKEEL--------------MK-MRLPTRSDMICGYACLK--GN-------------------------AAMRNTKRGSWYIEALTQVFSE-------RA--CDMHVAD P_pygmaeus_ENSPPYP00000017020 -------------DDDM--------------AC-HKIPVEADFLYAYSTAP--GY-------------------------YSWRNSKDGSWFIQSLCAMLKQ-------YA--DKLEFMH M_musculus_ENSMUSP00000091238 -------------DEEM--------------AC-QKIPVEADFLYAYSTAP--GY-------------------------YSWRNSKDGSWFIQSLCSMLKL-------YA--HKLEFMH O_anatinus_ENSOANP00000015596 PFQAAPED----YDEPD--------------AV-ASLPTPSDILVSYSTFP--GF-------------------------VSWRDTQSGSWYIETLDSVLDQ-------WA--HTEDLLT M_mulatta_ENSMMUP00000016588 ------------GKEKL--------------PK-MRLPTRSDMICGYACLK--GT-------------------------AAMRNTKRGSWYIEALAQVFSE-------RA--CDMHVAD D_rerio_ENSDARP00000071815 -------------VGDE--------------ET-QRIPVEADFLYAYSTAP--GY-------------------------YAWRNVANGSWFISSLCDMLLK-------YG--KQLEIMQ D_rerio_ENSDARP00000083664 ------------GREGERDNREKKEEKERERLR-VKLPQRSDMICGFATLK--GT-------------------------AAMRNTKKGSWFIQELNTAIRQ-------RA--NNTHLSD E_caballus_ENSECAP00000003321 ------------GKEEL--------------LK-MRLPTRSDMICGYACLK--GT-------------------------AAMRNTKRGSWYIEALTQVFSE-------RA--CDMHVAD P_troglodytes_ENSPTRP00000054330 -------------DDDM--------------AC-HKIPVEADFLYAYSTAP--GY-------------------------YSWRNSKDGSWFIQSLCAMLKQ-------YA--DKLEFMH H_sapiens_ENSP00000311032 -------------DDDM--------------AC-HKIPVEADFLYAYSTAP--GY-------------------------YSWRNSKDGSWFIQSLCAMLKQ-------YA--DKLEFMH M_domestica_ENSMODP00000005560 -------------DEDV--------------AC-HKIPVEADFLYAYSTVP--GY-------------------------YSLRDPKDGSWFIQALCAVLKQ-------HA--HKLEIMQ P_pygmaeus_ENSPPYP00000020323 ------------GKEKL--------------PK-MRLPTRSDMICGYACLK--GT-------------------------AAMRNTKRGSWYIEALAQVFSE-------RA--CDMHVAD H_sapiens_ENSP00000312664 ------------GKEKL--------------PK-MRLPTRSDMICGYACLK--GT-------------------------AAMRNTKRGSWYIEALAQVFSE-------RA--CDMHVAD P_troglodytes_ENSPTRP00000033921 ------------GKEKL--------------PK-MRLPTRSDMICGYACLK--GT-------------------------AAMRNTKRGSWYIEALAQVFSE-------RA--CDMHVAD D_rerio_ENSDARP00000006831 -------------DIPD--------------GR-VRIPVEADFLYAYSTVP--GY-------------------------YSWRNTMTGSWFIQSLCEMMTK-------YG--SELELLQ R_norvegicus_ENSRNOP00000022693 -------------TDAN--------------PR-YKIPVEADFLFAYSTVP--GY-------------------------YSWRNPGKGSWFVQALCSILNE-------HG--KDLEIMQ M_musculus_ENSMUSP00000026062 -------------IDAN--------------PR-NKIPVEADFLFAYSTVP--GY-------------------------YSWRNPGKGSWFVQALCSILNE-------HG--KDLEIMQ M_domestica_ENSMODP00000036247 ------------D-KSF--------------QS-ECIPNEADFLLGMATVE--NY-------------------------VSYRDSARGTWYIQSLCKNLKE-------GCL-RGNDILT E_caballus_ENSECAP00000019797 -------------EDDM--------------AC-QKIPVEADFLYAYSTAP--GY-------------------------YSWRNSKDGSWFIQSLCAMLKL-------YA--HKLELMH G_aculeatus_ENSGACP00000024816 -------------VGGQ--------------TS-DRIPVEADFLYAYSTAP--GY-------------------------YAWRNTQNGSWFMQSLCEMLRR-------FS--GQLELMQ C_intestinalis_ENSCINP00000007986 ------------SSNDH--------------IR-NKLPQKSDMLIGQATMK--GF-------------------------AAMRNTKHGSWYIQAFVRVLAR-------HA--CDTDLLD B_taurus_ENSBTAP00000008706 -------------TDAN--------------PR-YKIPVEADFLFAYSTVP--GY-------------------------YSWRNPGSGSWFVQALCSILNE-------HG--KSLEILQ C_familiaris_ENSCAFP00000032189 -------------EDDM--------------AC-QKIPVEADFLYAYSTAP--GY-------------------------YSWRNSKDGSWFIQSLCAMLKL-------YA--HKLEFMH D_rerio_ENSDARP00000072390 -------------EDFF--------------GI-SDVP-ELDFLCCYSTVE--GY-------------------------FAWRNPETGSIFIRELCKTLMD-----------CRLEIIQ B_taurus_ENSBTAP00000038128 ------------D-SSP--------------QK-RYIPDEADFLLGMATVK--NY-------------------------VSYRNIWNGAWYIQSLCQNLRE-------RCP-RGEDILT G_aculeatus_ENSGACP00000016983 ------------QADDS--------------PS-PTIPKEADVLVAVATVE--DY-------------------------LAFRHITDGSWFIQSVCEQLKD-------GCP-RGEDITT G_gallus_ENSGALP00000013506 ------------PQSTS--------------PS-ESIPEEADFLLGMATID--GY-------------------------ASFRHVQEGTWYIQALCSKLQL-------LVPSRGEDILS A_gambiae_AGAP000830-PA ------------SSSSM--------------LT-FKIPMYADFMIAYSTIP--GF-------------------------YSWRNTQKGSWFIQSLCHELNQ-------NG--RKYDLMV T_guttata_ENSTGUP00000010625 ------------D-ARF--------------QL-DCIPAEADFLLGMATLQ--DY-------------------------VSYRSPKEGTWYIQALCQHLEY-------SCP-RGEDVLT G_aculeatus_ENSGACP00000013740 ------------GREGQGD-ASARQRGDM--GR-IKLPQRSDMICGFASLK--GT-------------------------AAMRNTKRGSWFVQELNKRLRL-------HA--RDTHLAD M_mulatta_ENSMMUP00000015808 -------------EDDM--------------AC-HKIPVEADFLYAYSTAP--GY-------------------------YSWRNSKDGSWFIQSLCAMLKQ-------YA--DKLEFMH G_gallus_ENSGALP00000013571 ------------ETDAI--------------PA-LSIPDQADVLVGMATVE--DF-------------------------ECYRSIETGSVYIQCLCDKMEL-------LCP-LRKDLIT G_gallus_ENSGALP00000014503 ------------ETDAN--------------PR-YKIPVEADFLFAYSTVP--GY-------------------------YSWRNPGRGSWFVQSLCSVLNE-------HG--KQLEIMQ A_gambiae_AGAP011951-PA ------------SSPGS--------------MR-YVIPAMADLLVMYSTYD--GH-------------------------YSWRNPSKGSWFIQSLCAELGA-------SA--HCKELLH P_pygmaeus_ENSPPYP00000003106 -------------TDAN--------------PR-YKIPVEADFLFAYSTVP--GY-------------------------YSWRSPGRGSWFVQALCSILEE-------HG--KDLEIMQ O_latipes_ENSORLP00000015114 ------------GREEQGD-ADGRQRASTGRQR-IKLPQRSDMICGFASLK--GT-------------------------AAMRNTKKGSWFIQELNTALRL-------NA--RDTHLAD C_familiaris_ENSCAFP00000016420 -------------TDAN--------------PR-YKIPVEADFLFAYSTVP--GY-------------------------YSWRSPGSGSWFVQALCSTLNE-------HG--KSLEILH P_troglodytes_ENSPTRP00000005216 -------------TDAN--------------PR-YKIPVEADFLFAYSTVP--GY-------------------------YSWRSPGRGSWFVQALCSILEE-------HG--KDLEIMQ T_nigroviridis_ENSTNIP00000009934 -------------IEDN--------------ST-TKIPVEADFLYAFSTAP--GY-------------------------YSWRNTMSGSWFMQSLCDTISK-------YG--KELELQH G_aculeatus_ENSGACP00000024812 -------------TDGQ--------------ML-QSIPLEADFLYAYSTPS--GY-------------------------YSWRNTQNGSCFMQSLCEILHS-------FS---QLELMQ O_latipes_ENSORLP00000010793 --------------KDD--------------TS-EKIPLEADFLFAYSTVS--GY-------------------------YSWRSTANGSWFIQSLCEMLEK-------FS--KTLDLMQ B_taurus_ENSBTAP00000024166 ------------SREEL--------------LK-MRLPTRSDMICGYACLR--GT-------------------------AAMRNTKRGSWYVEALTQVFSE-------RA--CDMHVAD G_gorilla_ENSGGOP00000007184 -------------TDAN--------------PR-YKIPVEADFLFAYSTVP--GY-------------------------YSWRSPGRGSWFVQALCSILEE-------HG--KDLEIMQ T_rubripes_ENSTRUP00000045375 PMSSSSDSLSM-SDEPD--------------AR-ASLPTPSDILVSYSTFP--GY-------------------------VSWRDTQSGSWYIETLDRILEE-------NA--ATDDLVT G_gallus_ENSGALP00000013591 ------------D-ARF--------------QL-DCIPSEADFLLGMATLQ--DY-------------------------VSYRSPSQGTWYIQSLCQHLES-------SCP-RGEDILT T_nigroviridis_ENSTNIP00000013855 PVSSSSDSLSM-SDEPD--------------AR-ASLPTSSDILVSYSTFP--GY-------------------------VSWRDPKAGSWYVETLDRVLEE-------NA--ALHDLVV A_carolinensis_ENSACAP00000002670 --------------DES--------------MC-QKIPVEADYLYAYSTAP--GY-------------------------YSWRNSSDGSWFIQSLCSMLKQ-------YS--HKLELMQ A_aegypti_AAEL003444-PA ------------SRQEQ--------------VL-YSIPAMADLLVMYSTYD--GY-------------------------YSWRNPRQGSWFIQSLCTELDE-------NG--RVRDLLT O_cuniculus_ENSOCUP00000009498 -------------TDAN--------------PR-HKIPVEADFLFAYSTVP--GY-------------------------YSWKNPGRGSWFVQALCSILDE-------HG--KELEVMQ T_guttata_ENSTGUP00000011206 ------------ETDAN--------------PR-YKIPVEADFLFAYSTVP--GY-------------------------YSWRNPGRGSWFVQSLCSVLNE-------HG--KQLEIMQ A_gambiae_AGAP004921-PA ------------DHFSS--------------HK-YVIPTTADLLVMYSSYK--GH-------------------------VSWRSPRGGSWFIQALCVELET-------NW--KHMELLQ H_sapiens_ENSP00000358327 -------------TDAN--------------PR-YKIPVEADFLFAYSTVP--GY-------------------------YSWRSPGRGSWFVQALCSILEE-------HG--KDLEIMQ A_carolinensis_ENSACAP00000001629 ------------FPLQQ--------------MI-SSIPEEADFLLGMATVD--GY-------------------------LSFRHVHQGTWYIQALCDKLRT-------LVP-RGEDILS D_rerio_ENSDARP00000063081 ------------VDGDD--------------FD-ITIPSDTDFLIARSTTD--GH-------------------------VSYRKPDEGSWFIQSLCRNLEK-------HCP-LGADILT X_tropicalis_ENSXETP00000008971 -------------ENKK--------------YV-VNVPKDADFLLGMSTVD--GY-------------------------AAYRHTREGSWYIQALCKNLVE-------LVP-RGEDILA T_guttata_ENSTGUP00000017449 PFRVPSDN----VDEPD--------------AI-ASLPTPSDILVSYSTFP--GF-------------------------VSWREKSSGSWYVETLDSVLEQ-------YA--HSEDLLS T_rubripes_ENSTRUP00000037606 ------------GREGR--------------PR-IKLPQRSDMICGFASLK--GQDS-----------------------SHAEHQKRGSWFIQELNTALRL-------HA--RDRHLAD E_caballus_ENSECAP00000013731 -------------TDAN--------------PR-YKVPVEADFLFAYSTVP--GY-------------------------YSWRNPGSGSWFVQALCSILNE-------HG--KSLEIIQ C_familiaris_ENSCAFP00000005409 ------------SKEEL--------------LK-TRLPTRSDMICGYACLR--GT-------------------------AAMRNTKRGSWYIEALTQVFSE-------RA--CDTHVAD D_rerio_ENSDARP00000034228 ------------PIEIE--------------DD-DFVHKEKDFISLMSCTP--DT-------------------------KSYRHVQNGTFYVQTLVDVFIK-------CA--HEDHIEE T_nigroviridis_ENSTNIP00000022078 ------------ETDAN--------------PR-HKIPVEADFLFAYSTVP--GY-------------------------YSWRNPGRGSWFVQALCNVLNE-------FG--KQLEIMQ D_melanogaster_FBpp0084848 ------------DGDSS--------------MS-YKIPVHADFLIAYSTVP--GF-------------------------YSWRNTTRGSWFMQSLCAELAA-------NG--KRLDILT M_mulatta_ENSMMUP00000001627 -------------TDAN--------------PR-YKIPVEADFLFAYSTVP--GY-------------------------YSWRSPGRGSWFVQALCSILEE-------HG--KDLEIMQ T_rubripes_ENSTRUP00000040691 -------------AADS--------------ST-TKIPVEADFLYAFSTAP--GY-------------------------YSWRNTTSGSWFMQSLCDAISK-------YG--KELELQH A_gambiae_AGAP011950-PA ------------SPEKP--------------IC-VEIPMYADLLVMYSSYD--QY-------------------------VSYRDKEEGSWFIQSLCQVLGA-------NI--AGKDLLT D_rerio_ENSDARP00000047019 PMSSSSDSLSTASDELD--------------AR-ASLPTPSDILVSYSTFP--GY-------------------------VSWRDTEAGSWYVENLDRVLEE-------NA--ITDDLVT C_familiaris_ENSCAFP00000023986 PFQEGPGP----FDQLD--------------AV-SSLPTPSDIFVSYSTFP--GF-------------------------VSWRNTKSGSWYVETLDGVFEQ-------WA--HAEDLQT T_rubripes_ENSTRUP00000031759 ------------ETDAN--------------PR-HKIPVEADFLFAYSTVP--GY-------------------------YSWRNPGRGSWFVQALCNVLSE-------FG--KQLEIMQ C_intestinalis_ENSCINP00000024485 ------------GAASH--------------GR-QVLPSESDFLIGHSTVP--GY-------------------------LSYRSRTDGSWFISTLVDSLEK-------YH--EKEDLLS A_gambiae_AGAP011952-PA ------------SSSSQ--------------RT-CVIPTMADVLVMYSAFD--GH-------------------------YSWRNPTHGSWFIQSLSIELNQ-------HA--HRKELLQ C_familiaris_ENSCAFP00000017899 ------------D-SSY--------------QK-RYIPEDADFLLGMATVN--NC-------------------------VSYRNPMEGTWYIQSLCQSLRE-------RCP-RGEDILT A_gambiae_AGAP011949-PA ------------CSVDP--------------AP-GIIPMYADLLVMYSSYD--RH-------------------------ISVRCKDKGSWFIQSLCQVLRA-------NI--AGKELIS G_aculeatus_ENSGACP00000022402 --------------VKD--------------ET-TRIPVEADFLYAFSTAP--GY-------------------------YSWRNTTTGSWFMQSLCDMISK-------YG--KELELQH T_nigroviridis_ENSTNIP00000001216 ------------D-AVR--------------LS-NCIPSHADFLLGMATVP--DY-------------------------VSYRDRERGTWYIQSLCEYLVK-------MVP-RGFDLMS A_gambiae_AGAP004920-PA ------------CPKSS--------------IQ-YAIPSMADLLVMYSTYK--GH-------------------------YSWRNPSTGSWFIRALCDELRE-------HG--NSKELLQ X_tropicalis_ENSXETP00000003217 -------------EPGE--------------EI-QRIPVEADFLYAYSTVP--GY-------------------------YSWRNTMNGSWFIQSLCEMIKL-------YG--PHLELIQ O_latipes_ENSORLP00000010095 ---------------KE--------------DT-TKIPVEADFLYAFSTAP--GY-------------------------YSWRNTMTGSWFINSLCEMLSK-------YG--KELELLH T_rubripes_ENSTRUP00000024164 ------------QTDDC--------------HT-LSIPEEADILVATATVE--DY-------------------------VSFRHKIDGSWFIQSLCQELKE-------GCL-RGEDMTT O_anatinus_ENSOANP00000006351 ------------D-AVF--------------HE-RCIPDEADFLLGMATVS--NC-------------------------VSYRIPSKGTWYIQSLCHHLRN-------LCP-LGADILT M_musculus_ENSMUSP00000030747 PYQEGPRP----LDQLD--------------AV-SSLPTPSDILVSYSTFP--GF-------------------------VSWRDKKSGSWYIETLDGILEQ-------WA--RSEDLQS D_rerio_ENSDARP00000019984 ------------ETDAN--------------PR-HKIPVEADFLFAYSTVP--GY-------------------------YSWRNPGRGSWFVQALCNVLSE-------FG--KQLEIMQ G_aculeatus_ENSGACP00000005791 ------------D-AFK--------------AS-DAIPSEADFLLGMSTVP--SF-------------------------VSYRHRKNGSWFIESLCQNLVQ-------MVP-KL----- C_familiaris_ENSCAFP00000016791 ------------EVDAA--------------SV-YTLPAGADFLMCYSVAE--GY-------------------------YSHRETVNGSWYIQDLCEMLGK-------FG--SSLEFTE C_intestinalis_ENSCINP00000003204 ------------EVDAA--------------PV-PTLPSGSDYLFCYSVAE--GY-------------------------YSHRDTLYGSWFIQDFTDVMEQLVLNKGKQQ--DKVDFID G_aculeatus_ENSGACP00000008661 ------------ETDAN--------------PR-HKIPVEADFLFAYSTVP--GY-------------------------YSWRNPGRGSWFVQALCNVLNE-------FG--KQLEIMQ E_caballus_ENSECAP00000015102 PFQEGPGT----FDQPD--------------AV-SSLPTPSDIFVSYSTFP--GF-------------------------VSWRDPKSGSWYVETLDGVFEQ-------WA--HSEDLQT B_taurus_ENSBTAP00000003205 PFQEGPRS----IDEPD--------------AV-SSLPTPSDILVSYSTFP--GF-------------------------VSWRDPKSGSWYIETLDSIFEQ-------WA--HCEDLQT G_aculeatus_ENSGACP00000007379 PMSSSSDSLSL-SDEVD--------------AR-ATLPTPSDILVSYSTFP--GY-------------------------VSWRDTQSGSWYVETLDQVLEQ-------NA--ATDDLVT C_elegans_C48D1.2 GCVR--------PQVQQ--------------VW-RKKPSQADILIAYATTA--QY-------------------------VSWRNSARGSWFIQAVCEVFST-------HA--KDMDVVE A_gambiae_AGAP009832-PA ------------QKDGV--------------AR-YSIPTHADFLFAYATIP--GF-------------------------MAFRNTTEGSWFINELCKELQE-------NG--HRYDINT D_rerio_ENSDARP00000093958 ------------AVDAG--------------VS-NTLPAGADFIMCYSTTE--GF-------------------------CSFRDPLNGTWYIQDLCEIMGR-------YR--SQLEFTN C_familiaris_ENSCAFP00000032442 ------------RRWLR--------------AS-PTTPSHADVLEIYTDAQ--GGVCLPLEPGLGRPGG-----RAVWRCVAYRD-EKGSDFIQTLAEVLRA-------D---PGGDLLE G_gallus_ENSGALP00000002083 PFQAPSGN----EDEPD--------------AV-ASLPTPGDILVSYSTFP--GF-------------------------VSWRDKVSGSWYVETLDSVLEH-------YA--RSEDLLT A_gambiae_AGAP012544-PA ------------GLEEP--------------VD-VKIPMYADLLVMYSSFE--HH-------------------------SSIRCRNEGSWFIQSFCQVLGA-------NI--AKTELQA D_rerio_ENSDARP00000075318 ------------QKPGR--------------VS-VSIPKDSDFLIARSTVE--GY-------------------------VSIRDRTSGTWFIQSLCENLKE-------GSK-RGHDILM R_norvegicus_ENSRNOP00000017972 PYQEGPRT----LDQLD--------------AV-SSLPTPSDILVSYSTFP--GF-------------------------VSWRDKKSGSWYIETLDGVLEQ-------WA--RSEDLQS H_sapiens_ENSP00000286186 ------------QAPTS--------------LQ-DSIPAEADFLLGLATVP--GY-------------------------VSFRHVEEGSWYIQSLCNHLKK-------LVP-RHEDILS P_pygmaeus_ENSPPYP00000014602 ------------QPPTS--------------LQ-DSIPAEADFLLGLATVP--GY-------------------------VSFRHVEEGSWYIQSLCNHLKK-------LVP-RHEDILS P_pygmaeus_ENSPPYP00000014606 ------------DLSSP--------------QT-RYIPDEADFLLGMATVN--NC-------------------------VSYRNPAEGTWYIQSLCQSLKE-------RCP-RGDDILT A_aegypti_AAEL014348-PA -------------KDGV--------------AR-YSIPTNADFLFAFATIP--GY-------------------------MSFRNTKNGSWFIRELCNELNE-------NG--QRYDMLT M_musculus_ENSMUSP00000029626 ------------QVDAA--------------SV-YTLPAGADFLMCYSVAE--GY-------------------------YSHRETVNGSWYIQDLCEMLAR-------YG--SSLEFTE O_latipes_ENSORLP00000003208 PFSSSSESLST-SDETD--------------AI-PTLPTPSDILVSYSTFP--GY-------------------------VSWRATVSGSWYVEVLDNILEE-------HA--ATLDLTT D_melanogaster_FBpp0071971 ------------DGESS--------------TS-YKIPIHADFLFSYSTIP--GY-------------------------FSWRNINNGSWYMQSLIRELNA-------NG--KKYDLLT O_anatinus_ENSOANP00000002508 -------------SDAN--------------PG-CRIPVEADFLFAYSTVPVKGY-------------------------YSWRNVDRGSWFVQALCSVLHE-------HG--KELEIMQ M_mulatta_ENSMMUP00000037892 ------------DLSSP--------------QT-RYIPDEADFLLGMATVN--NC-------------------------VSYRNPAEGTWYIQSLCQSLRE-------RCP-RGDDILT T_rubripes_ENSTRUP00000044662 ------------N-AVQ--------------AK-ECIPSHADFLLGMATVP--SF-------------------------VSFRDGTHGTWYIQSLCQNLAD-------MVP-RGCDLIS D_rerio_ENSDARP00000075650 ------------VEGDN--------------LD-ITIPSDTDFLIARSTTN--GH-------------------------VSYRHVREGSWFIQSLCRNLEK-------HCP-RGADILT E_caballus_ENSECAP00000013268 ------------QVDAA--------------SV-YTLPAGADFLMCYSVAE--GY-------------------------YSHRETINGSWYIQDLCEMLAR-------FG--SSLEFTE X_tropicalis_ENSXETP00000035938 ------------ETDAN--------------PR-HKIPVEADFLYAYSTVP--GY-------------------------YSWRNPGRGSWFVQALCNVLNE-------HG--KELEVMQ A_aegypti_AAEL011562-PA ------------NLKKD--------------PP-TNMPTYADMLICFSTVP--GY-------------------------AAHRDKQYGSWFVESMCKVWAQ-------HA--HDTDVEQ E_caballus_ENSECAP00000004055 ------------D-SSF--------------QK-RCIPDEADFLLGMATVN--NC-------------------------VSYRNPLEGTWYIQSLCQSLRE-------RCP-RGEDILT 850 860 870 880 890 900 =========+=========+=========+=========+=========+=========+======= H_sapiens_ENSP00000221740 LLTEVTRRMAEA--------ELVQEGKARKTNPEI-QSTLRKRLYLQ-------------------- M_mulatta_ENSMMUP00000024183 LLTEVTRRMAEA--------EMVQEGQAKKTNPEI-QSTLRKRLYLQ-------------------- C_familiaris_ENSCAFP00000023821 LLTEVTRRMAEA--------ELVQEGKPRKVNPEI-QSTLRKRLYLQ-------------------- E_caballus_ENSECAP00000010379 LLTEVTRRMAEA--------ELVQEGRTRKVNPEI-QSTLRKRLYLQ-------------------- B_taurus_ENSBTAP00000028116 LLTEVTRRMAEA--------EMVQEGEAKKVNPEI-QSTLRKQLYLQ-------------------- O_cuniculus_ENSOCUP00000002346 LLTEXXXXXXXX--------XXXQEGKARKVNPEI-QSTLRKRLYLQ-------------------- R_norvegicus_ENSRNOP00000009643 LLEEITRLMANT--------EVMQEGKPRKVNPEI-QSTLRKKLYLQ-------------------- P_pygmaeus_ENSPPYP00000010831 ------------------------------------------------------------------- M_musculus_ENSMUSP00000005488 LTEEITRLMANT--------EVMQEGKPRKVNPEV-QSTLRKKLYLQ-------------------- G_gorilla_ENSGGOP00000000424 LLTEXXXXXXXX--------XXXXXXXXXXXXXXX-XXXXXKRLYLQ-------------------- M_domestica_ENSMODP00000018104 LLTEVTRRMADA--------ELMEEGKPRKVNPEV-QSTLRKLLYL--------------------- O_anatinus_ENSOANP00000013840 ------------------------------------------------------------------- M_domestica_ENSMODP00000020556 LLTEVNKRLCEM------EVRGPDCDEIRKMSVEI-QSSLRKQLYLK-------------------- E_caballus_ENSECAP00000006138 LLTEVNRRVCEL------DVLGPDSDERRKACLEI-RSSLRRRLCLQA------------------- M_mulatta_ENSMMUP00000027593 LLTEVNRRMCEQ------DVLGPDCDELRKACLEI-RSSLRRRLCLQP------------------- B_taurus_ENSBTAP00000045524 LMTEVNRQVCEL------DVLGPDCDDRRKACLEI-RSSLRRRLCLQ-------------------- B_taurus_ENSBTAP00000012869 FFTIVNNRVVHR--------DFNLCNKPVKVSLVM-ESTLTKFVYF--------------------- M_domestica_ENSMODP00000032734 FFTQVNNLVVHT--------DFYINRNPAKVVLVM-ESTLTKAVYF--------------------- C_familiaris_ENSCAFP00000007585 FFTRVNNRVVHT--------EFHLHEEPIKVSLVM-ESTLTKSVYF--------------------- O_cuniculus_ENSOCUP00000000197 LLTEVNRRVCEL------DVLGPDCDEPRKACLEI-RSSLRRRLRLRV------------------- A_carolinensis_ENSACAP00000013788 LFTKVNSKMIQR------DFHLEGEEESVKVTIVM-ESTLTKALYL--------------------- O_anatinus_ENSOANP00000019254 LFTKSLLKALPS----------LLEGGIVKVTLEM-QSTLTRAVYLG-------------------- E_caballus_ENSECAP00000017996 FFTRVNNRVVHT--------EFHLREEPIKVSLVM-ESTLTKSVYF--------------------- T_guttata_ENSTGUP00000006879 ILTRVNRRVA-E---YESCS-TRQDFNAKKQIPCI-VSMLTKEFYF-PS------------------ A_carolinensis_ENSACAP00000006831 MLVKVNRLIKLR----EGHA-PGTEFHRCKEMSEY-CSTLCQDLYLFPGYFPG-------------- O_anatinus_ENSOANP00000000517 ILTRVNRKVATE---FESYS-LDATFNAKKQIPCI-VSMLTKELYF-PY------------------ T_guttata_ENSTGUP00000013612 MLVKVNRQIKQR----EGYA-PGTEYHRCKEMSEY-CSTLCRDLYLFPGYLPGK------------- M_domestica_ENSMODP00000005556 ILTRVNRKVATE---FESYS-LDISFHAKKQVPCI-MSMLTKELYF-SH------------------ G_gallus_ENSGALP00000029853 MLVKVNRQIKQR----EGYA-PGTEFHRCKEMSEY-CSTLCRDLYLFPGYVPGK------------- A_carolinensis_ENSACAP00000009923 ILTMVNYKVARN---YESQS-DDPRFSQKKQVPCV-VSMLTKELYF--------------------- G_gallus_ENSGALP00000017288 ILTRVNRRVA-E---YESCS-TRQDFNAKKQIPCI-VSMLTKEFYF-PC------------------ X_tropicalis_ENSXETP00000015203 MLVKVNALIKER----EGHA-PGTEFHRCKEMSEY-CSTLCRDLYLFPG------------------ M_domestica_ENSMODP00000001598 ML--VNALIKDR----EGYA-PGTEFHRSKEMSEY-SSTLCRHLYLFPGHPPT-------------- D_rerio_ENSDARP00000024255 ILTKVNADVSKK--------SD--KSGLKKQMPQP-EFSLTRTVVF-PPPGLP-------------- R_norvegicus_ENSRNOP00000014096 ILTRVNRKVATE---FESFS-LDATFHAKKQIPCI-VSMLTKELYF-YH------------------ G_aculeatus_ENSGACP00000024809 IMTRVNNKVALE---YKTT----PGRSGKRQMPCI-VSLLTKEFYF-P------------------- M_musculus_ENSMUSP00000031895 MLVKVNALIKER----EGYA-PGTEFHRCKEMSEY-CSTLCQQLYLFPGYPPT-------------- O_anatinus_ENSOANP00000005545 MLVKVS------------------------------------------------------------- B_taurus_ENSBTAP00000021099 ILTRVNRKVAIE---YESFS-TDSAFHAKKQIPCI-MSMLTKELYF--------------------- R_norvegicus_ENSRNOP00000022672 MLVKVNALIKER----EGYA-PGTEFHRCKEMSEY-CSTLCQQLYLFPGYPPT-------------- P_pygmaeus_ENSPPYP00000017020 ILTRVNRKVATE---FESFS-LDATFHAKKQIPCI-VSMLTKELYF-YH------------------ M_musculus_ENSMUSP00000091238 ILTRVNRKVATE---FESFS-LDSTFHAKKQIPCI-VSMLTKELYF-YH------------------ O_anatinus_ENSOANP00000015596 LLLRVSNGVSSK--------------GKYKQIPGC-FNFLRKRLFFNTK------------------ M_mulatta_ENSMMUP00000016588 MLVKVNALIKDR----EGYA-PGTEFHRCKEMSEY-CSTLCRHLYLFPGHPPT-------------- D_rerio_ENSDARP00000071815 VMTRVNHKVALE---FESSS-NLPGFDGKKQIPCI-VSMLTKELYF-PK------------------ D_rerio_ENSDARP00000083664 ILVQVNGQIKSR----EGYA-PGSAHHRCKEMSEF-TSSLCKDLYLFPKYYPSN------------- E_caballus_ENSECAP00000003321 MLVKVNALIKER----EGYA-PGTEFHRCKEMSEY-CSTLCRHLYLFPGHPPT-------------- P_troglodytes_ENSPTRP00000054330 ILTRVNRKVATE---FESFS-FDATFHAKKQIPCI-VSMLTKELYF-YH------------------ H_sapiens_ENSP00000311032 ILTRVNRKVATE---FESFS-FDATFHAKKQIPCI-VSMLTKELYF-YH------------------ M_domestica_ENSMODP00000005560 ILTRVNRKVATE---FESYS-SKASLHAKKQMPCI-MSMLTKELYF-SH------------------ P_pygmaeus_ENSPPYP00000020323 MLVKVNALIKDR----EGYA-PGTEFHRCKEMSEY-CSTLCRHLYLFPGHPPT-------------- H_sapiens_ENSP00000312664 MLVKVNALIKDR----EGYA-PGTEFHRCKEMSEY-CSTLCRHLYLFPGHPPT-------------- P_troglodytes_ENSPTRP00000033921 MLVKVNALIKDR----EGYA-PGTEFHRCKEMSEY-CSTLCRHLYLFPGHPPT-------------- D_rerio_ENSDARP00000006831 IMTRVNHKVALD---FESTS-NMPGFDAKKQIPCI-VSMLTKEMYFTP------------------- R_norvegicus_ENSRNOP00000022693 ILTRVNDRVARH---FESQS-DDPRFNEKKQIPCM-VSMLTKELYFGR------------------- M_musculus_ENSMUSP00000026062 ILTRVNDRVARH---FESQS-DDPRFNEKKQIPCM-VSMLTKELYFSR------------------- M_domestica_ENSMODP00000036247 ILTEVNSEVSQK--------TD--PKNNGKQMPQP-KITLRKKLVF-PI---S-------------- E_caballus_ENSECAP00000019797 ILTRVNRKVAME---FESYC-LDPTFHGKKQIPCI-VSMLTKELYF-YH------------------ G_aculeatus_ENSGACP00000024816 IMTRLNHRVALH---FESSS-DTPGYSGKKQIPCI-VSMLTKDFYF-PK------------------ C_intestinalis_ENSCINP00000007986 MMTKVNNILKHK----EGWC-PGSVYHRCKVMPEF-KSSLSKKLYFFPGI----------------- B_taurus_ENSBTAP00000008706 ILTRVNDRVARH---FESQS-DDPRFHEKKQIPCV-VSMLTKELYF--------------------- C_familiaris_ENSCAFP00000032189 ILTRVNRKVATE---FESFS-LDSAFHGKKQIPCI-VSMLTKELYL-YH------------------ D_rerio_ENSDARP00000072390 ILTRVNHLVAYY---FQSYT-LELETNRKRQMPCF-ASRLTKDFYLHV------------------- B_taurus_ENSBTAP00000038128 ILTKVNFEVSKL--------DD--KQRMAKQMPQP-TFTLRKKLFF-PL---N-------------- G_aculeatus_ENSGACP00000016983 ILQRVNWEVGKK--------EGCSAPGAGKQMPEV-RFTLRKKLVLSPHPNCFVAK----------- G_gallus_ENSGALP00000013506 ILTEVNEDVSKR--------VD--RYGTRKQMPQP-AYTLRRKLIF-PIPRDPPPS----------- A_gambiae_AGAP000830-PA LLTFVTQRVAYD---FESNTPDIPMMHQQKQIPCT-TSMLTRLVYFNQKK----------------- T_guttata_ENSTGUP00000010625 ILTAVNQEVSKK--------TC--ERDAKKQMPQP-SFTLRKRLIF-PV---N-------------- G_aculeatus_ENSGACP00000013740 IMVQVNRHIKER----EGYA-PGTAHHRCKEMSEF-TSSLCKDLYLFPKYQPQ-------------- M_mulatta_ENSMMUP00000015808 ILTRVNRKVATE---FESFS-LDATFHAKKQIPCI-VSMLTKELYF-YH------------------ G_gallus_ENSGALP00000013571 ILTEVNKEVGRR------------VLNGWKQMPKI-TSTLRKQFIF-QIPQCQ-------------- G_gallus_ENSGALP00000014503 ILTRVNYVVATN---FESQS-DDPRFSEKKQIPCV-VSMLTKELYF--------------------- A_gambiae_AGAP011951-PA ILTAVSRRVAYH---YQSNVPDNAKIDAKKQMPCM-VSMLTKLLYLRPKK----------------- P_pygmaeus_ENSPPYP00000003106 ILTRVNDRVARH---FESQS-DDPRFHEKKQIPCV-VSMLTKELYFSQ------------------- O_latipes_ENSORLP00000015114 ILVQVNKRIKER----EGYA-PGTAHHRCKEMSEF-TSSLCKDLYLFPKYQPQC------------- C_familiaris_ENSCAFP00000016420 ILTRVNNRVARH---FESQS-DDPHFHEKKQIPCV-VSMLTKELYF--------------------- P_troglodytes_ENSPTRP00000005216 ILTRVNDRVARH---FESQS-DDPRFHEKKQIPCV-VSMLTKELYFSQ------------------- T_nigroviridis_ENSTNIP00000009934 ILTRVNHKVAVE---FESDS-SLPGFNAKKQIPCI-VSMLTKEMYFS-------------------- G_aculeatus_ENSGACP00000024812 IMTRVNYEVALH---FESSS-DKLGYSGKKQIPCI-MSMLTKDFYF-PK------------------ O_latipes_ENSORLP00000010793 IMTRVNHKVATH---FESSS-NAPGFSGKKQIPCI-VSMLTKDFYF-PYESN--------------- B_taurus_ENSBTAP00000024166 MLVKVNALIKER----EGYA-PGTEFHRCKEMSEY-CSTLCRHLYLFPGHPPT-------------- G_gorilla_ENSGGOP00000007184 ILTRVNDRVARH---FESQS-DDPRFHEKKQIPCV-VSMLTKELYFSQ------------------- T_rubripes_ENSTRUP00000045375 MLMMVNHEVSQN-----------QAKGLYKQMPGS-FNFLRKLLYFQS------------------- G_gallus_ENSGALP00000013591 ILTAVNQEVSSK--------ID--KQNAGKQMPQP-SFTLRKKLIF-PV---N-------------- T_nigroviridis_ENSTNIP00000013855 MLTMVNDEVSQN-----------QAKGLYKQMPGS-FNFLRKRLYFIAQP----------------- A_carolinensis_ENSACAP00000002670 ILTRVNRKVT-E---FTSCS-NHPDFHGKKQIPCI-MSMLTKDFYF-PH------------------ A_aegypti_AAEL003444-PA LLTGVSRRTAYE---FQSFVPHNAKMDAMKQIPCI-VSMLTKTFYFTKKTRSRVVTDID-------- O_cuniculus_ENSOCUP00000009498 ILTRVNDRVARH---FESQS-DDPRFNEKKQIPCV-VSMLTKELYFCR------------------- T_guttata_ENSTGUP00000011206 ILTRVNYVVATN---FESQS-DDPRFSEKKQIPCV-VSMLTKELYF--------------------- A_gambiae_AGAP004921-PA LLTGVSRRVAYD---YQSNEPSKGRMDAMKQMPSI-VSMLTKLVYF-PLKLGS-------------- H_sapiens_ENSP00000358327 ILTRVNDRVARH---FESQS-DDPHFHEKKQIPCV-VSMLTKELYFSQ------------------- A_carolinensis_ENSACAP00000001629 ILTEVNADVSRR--------AD--AQGQKKQMPQP-AYTLRKKLIF-PIP----------------- D_rerio_ENSDARP00000063081 ILLSVNNEVSIQ-------------GLHSKQMPVH-EVAMRMKLILPPVNN---------------- X_tropicalis_ENSXETP00000008971 ILTKVNKDVSLK--------EG--QQGILKQMPQP-SYTLLKKLRF-PVPDVPFRPKTCQENSP--- T_guttata_ENSTGUP00000017449 MLVRVAHAVSAR--------------GRYKQIPGC-FNFLRKKFFFVCR------------------ T_rubripes_ENSTRUP00000037606 ILVQVNRRIKDR----EGYA-PGTAHHRCKEMSEF-TSSLCKDLFLFPKYQPQ-------------- E_caballus_ENSECAP00000013731 ILTRVNHRVARH---FESHS-DDPRFHQKKQIPCV-VSMLTKELYF--------------------- C_familiaris_ENSCAFP00000005409 MLVKVNALIKER----EGYA-PGTEFHRCKEMSEY-CSTLCRHLYLFPGHPPT-------------- D_rerio_ENSDARP00000034228 LFRKVLRRFEHP-----------NMIGNFKQMACKDRATLPKLFYLFPGL----------------- T_nigroviridis_ENSTNIP00000022078 ILTRVNYMVATS---FESWS-EDPRFSEKKQIPCV-VSMLTKELYFKPC------------------ D_melanogaster_FBpp0084848 LLTFVCQRVAVD---FESCTPDTPEMHQQKQIPCI-TTMLTRILRF-SDKQLAPAGRV--------- M_mulatta_ENSMMUP00000001627 ILTRVNDRVARH---FESQS-DDPCFHEKKQIPCV-VSMLTKELYFSH------------------- T_rubripes_ENSTRUP00000040691 ILTRVNHKVAVD---FESVS-NLPGFDAKKQIPCI-VSMLTKEMYFS-------------------- A_gambiae_AGAP011950-PA LLTHVSYLVSVRSFLMESEVNMVKRTGVLKQIPSI-NSMLTKAFYFVDK------------------ D_rerio_ENSDARP00000047019 MLMLVNDAVSQI-----------SAKGLYKQMPGS-FNFLRKLLYFQSSQS---------------- C_familiaris_ENSCAFP00000023986 LLLRVANAVSQK--------------GVYKQIPGC-FNFLRKKLYFKM------------------- T_rubripes_ENSTRUP00000031759 ILTRVNYMVATS---FESWS-EDPRFSEKKQIPCV-VSMLTKELYFKQC------------------ C_intestinalis_ENSCINP00000024485 IMINVNQEMASK---------------PYKQMPMP-IATLRKKVFF-SKQNSNSSSNQNCNTP---- A_gambiae_AGAP011952-PA LLTSVSRRVAYL---YESNVPGNEQMDGKKQMPCV-VSMLTKALYF-PRK----------------- C_familiaris_ENSCAFP00000017899 ILTEVNFEVSNK--------DD--RKNMGKQMPQP-TFTLRKKLFF-PP---N-------------- A_gambiae_AGAP011949-PA LLTQVSYIVSCQ-------TSITSDGETVKQIPSI-NSMLTKAFYFVPKQTQQIS------------ G_aculeatus_ENSGACP00000022402 IMVRVNHKVAVA---FESVS-NSPDFNARKQIPCV-VSMLTKEMYFSP------------------- T_nigroviridis_ENSTNIP00000001216 ILTKVNEDVSKK--------ND--NTGDRKQMPQP-VFTITKRIVF-PVPSGPAPVLPHFPFVEDSP A_gambiae_AGAP004920-PA LLTSVSRRVAYE---FQSNVPNNSQIDCQKQMPCI-VSMLTRRIYF-SKK----------------- X_tropicalis_ENSXETP00000003217 ILTCVNHMVALE---FESCS-TQQAFHAKKQIPCV-VSMLTKAFYF-LK------------------ O_latipes_ENSORLP00000010095 IMTRVNHMVAVE---FESIS-TLPGFHAKKQIPCI-VSMLTKEMYFYP------------------- T_rubripes_ENSTRUP00000024164 ILHRVNSEVSQK--------EAFIHPGEQKQMPEV-RFTLRKRLVLSPHTA---------------- O_anatinus_ENSOANP00000006351 ILTKVNFEVSQK--------ID--LTNRGKQMPQP-MFTLRKKLVL-PL---L-------------- M_musculus_ENSMUSP00000030747 LLLRVANAVSAK--------------GTYKQIPGC-FNFLRKKLFFKTS------------------ D_rerio_ENSDARP00000019984 ILTRVNYMVATS---FESWS-EDPRFSEKKQIPCV-VSMLTKELYFN-------------------- G_aculeatus_ENSGACP00000005791 ------------------------------------------------------------------- C_familiaris_ENSCAFP00000016791 LLTLVNRKVSQR---RVDFC-KDPNAIGKKQVPCF-ASMLTKKLHFFPKSK---------------- C_intestinalis_ENSCINP00000003204 VLTVVNRKVSAR---RVERS-YSQQALGKKQMPCY-LSMLTKKLYLTPKK----------------- G_aculeatus_ENSGACP00000008661 ILTRVNYMVATS---FESWS-EDPRFSEKKQIPCV-VSMLTKELYFN-------------------- E_caballus_ENSECAP00000015102 LLLRVAHAVSEK--------------GVYKQIPGC-FNFLRKKFFFKTY------------------ B_taurus_ENSBTAP00000003205 LLLRVANAVSVK--------------GIYKQMPGC-FNFLRKKLFFKT------------------- G_aculeatus_ENSGACP00000007379 MLMMVNHEVSQN-----------SAKGLYKQMPGS-FNFLRKLLHFQTHA----------------- C_elegans_C48D1.2 LLTEVNKKVACG---FQTSQ----GSNILKQMPEM-TSRLLKKFYFWPEARNSAV------------ A_gambiae_AGAP009832-PA LLTFVTQKVAYD---HESVS-NMPEYNMRKQTPCV-VSMLTRLLLF-NVV----------------- D_rerio_ENSDARP00000093958 ILTLVNRKVSLR------SICDDLSATGTKQMPCF-ASMLTKRLFFRPKK----------------- C_familiaris_ENSCAFP00000032442 LLTEVNRRVCEL------DVLGPDCPERRKACLEI-RSSLRRPLCL--------------------- G_gallus_ENSGALP00000002083 MLLRVSDIVSTK--------------GRYKQIPGC-FNFLRKKFFFLCK------------------ A_gambiae_AGAP012544-PA LLCHVSYLVSIR-----SDQTIDPEGKVVKQIPMV-TSMLTKAFYFVPK------------------ D_rerio_ENSDARP00000075318 ILTKVNNDVSRK----EGSLKVKNEIVDAKVTPQP-IFTLRKLLIFRPLKKTGRFS----------- R_norvegicus_ENSRNOP00000017972 LLLRVANAVSEK--------------GVYKQIPGC-FNFLRKKLFFKLH------------------ H_sapiens_ENSP00000286186 ILTAVNDDVSRR--------VD--KQGTKKQMPQP-AFTLRKKLVF-PVPLDALSL----------- P_pygmaeus_ENSPPYP00000014602 ILTAVNDDVSRR--------VD--KQGTKKQMPQP-AFTLRKKLVF-PVPLDALSL----------- P_pygmaeus_ENSPPYP00000014606 ILTEVNYEVSNK--------DD--KKNMGKQMPQP-TFTLRKKLVF-PS---D-------------- A_aegypti_AAEL014348-PA LLTFVVQKVAYG---YESYAPVHPDHHMKKQTPCV-VSMLTRLLLF-NNV----------------- M_musculus_ENSMUSP00000029626 LLTLVNRKVSQR---RVDFC-KDPDAIGKKQVPCF-ASMLTKKLHFCPKPSK--------------- O_latipes_ENSORLP00000003208 MLTLVNDKVSQN-----------SAKGLYKQMPGS-FNFLRKHVYFQTS------------------ D_melanogaster_FBpp0071971 LLTFVNQRVALD---FESNVPATPMMDRQKQIPCL-TSMLTRILRF-GDKPNGNKAG---------- O_anatinus_ENSOANP00000002508 LLTRVNHQVAIN---FESQA-SDPRYCQKKQIPCL-VSMLTKELYF--------------------- M_mulatta_ENSMMUP00000037892 ILTEVNYEVSNK--------DD--KKNMGKQMPQP-TFTLRKKLVF-PS---D-------------- T_rubripes_ENSTRUP00000044662 ILTKVNADVSKK--------VAWIDSGHKTQMPQP-AFTLTKKIVF-PAPNTPHPV----------- D_rerio_ENSDARP00000075650 ILLYVNNEVSSQ-------------KSIRKQMPIY-EVALTRKLFLRPVNP---------------- E_caballus_ENSECAP00000013268 LLTLVNRKVSQR---RVDFC-KDPSAIGKKQVPCF-ASMLTKKLHFFPKSK---------------- X_tropicalis_ENSXETP00000035938 ILTRVNYLVATQ---FESYC-DDPQFNKKKQIPCV-VSMLTKELYFKPC------------------ A_aegypti_AAEL011562-PA LMKLVGKDSSTY---------RTEHHNALQTLGSE-QRGFFNVLYLNPGYYED-------------- E_caballus_ENSECAP00000004055 ILTNVNFEVSSK--------DD--KKNMGKQMPQP-TFTLRKRLVF-PL---N--------------