10 20 30 40 50 60 70 80 90 100 110 120
=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000223500 -------------------------------------------------------------------------MNRLF--------G---------------------------------
M_mulatta_ENSMMUP00000026530 -------------------------------------------------------------------------MNRLF--------G---------------------------------
P_pygmaeus_ENSPPYP00000021442 -------------------------------------------------------------------------MNRLF--------G---------------------------------
C_familiaris_ENSCAFP00000002699 -------------------------------------------------------------------------MNRFF--------G---------------------------------
M_musculus_ENSMUSP00000030128 -------------------------------------------------------------------------MNRFF--------G---------------------------------
R_norvegicus_ENSRNOP00000011907 -------------------------------------------------------------------------MNRFF--------G---------------------------------
O_cuniculus_ENSOCUP00000007728 -------------------------------------------------------------------------MNRFF--------G---------------------------------
M_domestica_ENSMODP00000004938 -------------------------------------------------------------------------MNRFF--------G---------------------------------
B_taurus_ENSBTAP00000016431 -------------------------------------------------------------------------MNRFF--------G---------------------------------
A_carolinensis_ENSACAP00000009586 -------------------------------------------------------------------------MNRLF--------G---------------------------------
G_gallus_ENSGALP00000021459 -------------------------------------------------------------------------MNRFF--------G---------------------------------
T_guttata_ENSTGUP00000008472 -------------------------------------------------------------------------MNRFF--------G---------------------------------
E_caballus_ENSECAP00000007753 ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000014308 -------------------------------------------------------------------------MNRIF--------G---------------------------------
P_troglodytes_ENSPTRP00000035664 ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000022332 -------------------------------------------------------------------------MIRIF--------G---------------------------------
T_rubripes_ENSTRUP00000016981 -------------------------------------------------------------------------MNRIF--------G---------------------------------
G_aculeatus_ENSGACP00000005636 -------------------------------------------------------------------------MNRIF--------G---------------------------------
O_anatinus_ENSOANP00000005391 ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000022602 -------------------------------------------------------------------------MNRLF--------G---------------------------------
D_rerio_ENSDARP00000061395 -------------------------------------------------------------------------MNRIF--------G---------------------------------
T_rubripes_ENSTRUP00000028314 -------------------------------------------------------------------------MNRIF--------G---------------------------------
G_gorilla_ENSGGOP00000016137 ------------------------------------------------------------------------------------------------------------------------
D_rerio_ENSDARP00000056730 -------------------------------------------------------------------------MNRIF--------G---------------------------------
M_mulatta_ENSMMUP00000038110 --------------------------------------------------------------------------NSCF--------G---------------------------------
T_nigroviridis_ENSTNIP00000021817 -------------------------------------------------------------------------MNRIF--------G---------------------------------
X_tropicalis_ENSXETP00000010898 ------------------------------------------------------------------------------------------------------------------------
A_aegypti_AAEL005797-PA -------------------------------------------------------------------------MNRLF--------G---------------------------------
A_aegypti_AAEL012313-PA -------------------------------------------------------------------------MNRLF--------G---------------------------------
C_intestinalis_ENSCINP00000009854 -------------------------------------------------------------------------MNRIF--------G---------------------------------
R_norvegicus_ENSRNOP00000055831 -------------------------------------------------------------------------MNRFF--------G---------------------------------
A_gambiae_AGAP005100-PA -------------------------------------------------------------------------MNRLF--------G---------------------------------
D_melanogaster_FBpp0074964 -------------------------------------------------------------------------MNRLF--------G---------------------------------
C_elegans_F41E6.9 -------------------------------------------------------------------------MNRIF--------G---------------------------------
T_nigroviridis_ENSTNIP00000020259 -------------------------------------------------------------------------MNRIF--------G---------------------------------
S_cerevisiae_YDR486C -------------------------------------------------------------------------MNRIF--------G---------------------------------
C_intestinalis_ENSCINP00000022555 ------------------------------------------------------------------------MFKNMF--------G---------------------------------
C_intestinalis_ENSCINP00000029640 ------------------------------------------------------------------SHKRFKMFKNMF--------G---------------------------------
S_cerevisiae_YMR077C -------------------------------------------------------------------------M------------G---------------------------------
T_nigroviridis_ENSTNIP00000014973 ----------------------------------------------------------------------MSLLSKIF--------G---------------------------------
T_rubripes_ENSTRUP00000042469 ----------------LTPEWD-DDERMEFMFSAFKENRDVNTTDWDSKMAFWTALVLKSCRQRGSVYVSLQELNMIFRRKEKSPLGLPTVLQSLARCGKIQKESEFAASVDCGWLSWGV
D_melanogaster_FBpp0087704 ----------------------------------------------------------------------MSFFGKMF--------G---------------------------------
T_guttata_ENSTGUP00000017567 MCSPGEAPPGPAPAGGLPPEWETDDERMAFLFSAFKQSREVNSTEWDSKMAFWVGLVLARGRRRGAVRTCLRELQNGFERRGSVPLGLGTVLRELLRRGKLQRESDFMASVDSSWISWGV
O_latipes_ENSORLP00000013553 ----------------------------------------------------------------------MSKVSKLF--------SSSSKSK---------------------------
T_nigroviridis_ENSTNIP00000009347 ----------------------------------------------------------------------MSVLMKLF--------G---------------------------------
H_sapiens_ENSP00000324205 ---------------------------MSRRRPEDGLGKAGPCVMRHHPPRSKAEVWRTLRGGGGRGELAMSGLGRLF--------G---------------------------------
P_troglodytes_ENSPTRP00000010536 ---------------------------MSRRRPEDGLGKAGPCVMRHHPPRSKAEVWRTLRGGGGRGELAMSGLGRLF--------G---------------------------------
G_gorilla_ENSGGOP00000015698 ---------------------------TSRRRPEDGLGKAGPCVMRHHPPRSKAEVWRTPRGGGGRGELAMSGLGRLF--------G---------------------------------
C_elegans_R12C12.5 --------------------------------------------------------------------MPFKKMSWFFDRMHEEAHKIKEKIK---------------------------
T_rubripes_ENSTRUP00000021743 ----------------------------------------------------------------------MSKFTKLFKGSSSSSSSSSSKSR---------------------------
G_gallus_ENSGALP00000040164 MCSPGRAPPGPAPAGDLPPEWETDDE-----------XREVNSTEWHYKMAFWVGLVLARGRRRGVVRTCLRELQNGFERRGSVPLGLGTVLRELLRRGKMQRESDFMASVDSSWISWGV
130 140 150 160 170 180 190 200 210 220 230 240
=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000223500 --------------------------------------------------------------------------------------------------------KAKPKAPPPSLTDCIG
M_mulatta_ENSMMUP00000026530 --------------------------------------------------------------------------------------------------------KAKPKAPPPSLTDCIG
P_pygmaeus_ENSPPYP00000021442 --------------------------------------------------------------------------------------------------------KAKPKAPPPSLTDCIG
C_familiaris_ENSCAFP00000002699 --------------------------------------------------------------------------------------------------------KAKPKAPPPSLTDCIG
M_musculus_ENSMUSP00000030128 --------------------------------------------------------------------------------------------------------KAKPKAPPPSLTDCIG
R_norvegicus_ENSRNOP00000011907 --------------------------------------------------------------------------------------------------------KAKPKAPPPSLTDCIG
O_cuniculus_ENSOCUP00000007728 --------------------------------------------------------------------------------------------------------KAKPKAPPPSLTDCIG
M_domestica_ENSMODP00000004938 --------------------------------------------------------------------------------------------------------KAKPKAPPPSLTDCIG
B_taurus_ENSBTAP00000016431 --------------------------------------------------------------------------------------------------------KAKPKAPPPSLTDCIG
A_carolinensis_ENSACAP00000009586 --------------------------------------------------------------------------------------------------------KSKPKAPPPNLTDCIG
G_gallus_ENSGALP00000021459 --------------------------------------------------------------------------------------------------------KAKPKAPPPSLTDCIG
T_guttata_ENSTGUP00000008472 --------------------------------------------------------------------------------------------------------KAKPKEPPPSLTDCIG
E_caballus_ENSECAP00000007753 ----------------------------------------------------------------------------------------------------------SPAPPPPSLTTALL
O_latipes_ENSORLP00000014308 --------------------------------------------------------------------------------------------------------TGKPKAPPPNLSDCIG
P_troglodytes_ENSPTRP00000035664 ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000022332 --------------------------------------------------------------------------------------------------------RGKPKAPPPNLSDCIS
T_rubripes_ENSTRUP00000016981 --------------------------------------------------------------------------------------------------------SSKPKGPPPNLTDCIG
G_aculeatus_ENSGACP00000005636 --------------------------------------------------------------------------------------------------------RGKPKGPAPNLTDCIG
O_anatinus_ENSOANP00000005391 ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000022602 --------------------------------------------------------------------------------------------------------RGKPKTPPPNLSDCIG
D_rerio_ENSDARP00000061395 --------------------------------------------------------------------------------------------------------RGKPKGPPPNLTDCIS
T_rubripes_ENSTRUP00000028314 --------------------------------------------------------------------------------------------------------RSKPNPPPPNLSDCIG
G_gorilla_ENSGGOP00000016137 ------------------------------------------------------------------------------------------------------------------------
D_rerio_ENSDARP00000056730 --------------------------------------------------------------------------------------------------------RSK-QAASPNLSDCIG
M_mulatta_ENSMMUP00000038110 --------------------------------------------------------------------------------------------------------ESEIKAPPPSLNDCIG
T_nigroviridis_ENSTNIP00000021817 --------------------------------------------------------------------------------------------------------RSKPKTPPPNLSDCIG
X_tropicalis_ENSXETP00000010898 ------------------------------------------------------------------------------------------------------------------------
A_aegypti_AAEL005797-PA --------------------------------------------------------------------------------------------------------KSKPKEPGPSIDDCIK
A_aegypti_AAEL012313-PA --------------------------------------------------------------------------------------------------------KSKPKEPGPSIDDCIK
C_intestinalis_ENSCINP00000009854 --------------------------------------------------------------------------------------------------------SSKPKQPAPTLNDCIA
R_norvegicus_ENSRNOP00000055831 --------------------------------------------------------------------------------------------------------KAKPK-PPPSLTDCIG
A_gambiae_AGAP005100-PA --------------------------------------------------------------------------------------------------------KSKPKEPGPSISDCIS
D_melanogaster_FBpp0074964 --------------------------------------------------------------------------------------------------------RGKPKEPGPSLNDCIA
C_elegans_F41E6.9 --------------------------------------------------------------------------------------------------------TGK-KVPPPDLNNAIS
T_nigroviridis_ENSTNIP00000020259 --------------------------------------------------------------------------------------------------------SSKPKAPPPNLTDCIG
S_cerevisiae_YDR486C --------------------------------------------------------------------------------------------------------YGNKKSHDQLLQESNQ
C_intestinalis_ENSCINP00000022555 --------------------------------------------------------------------------------------------------------GGSKGKEKVSSQEAIQ
C_intestinalis_ENSCINP00000029640 --------------------------------------------------------------------------------------------------------GGSKGKEKVSSQEAIQ
S_cerevisiae_YMR077C --------------------------------------------------------------------------------------------------------QKSSKVHITKTDRAIL
T_nigroviridis_ENSTNIP00000014973 ---------------------------------------------------------------------------------------------------------GGKGAKAPSPQEAIQ
T_rubripes_ENSTRUP00000042469 GLLLVKPLKWTFSTLLGGSRVPPEEPFVV-IELVKEKAAEVLGAYRSSDLGGSSVLSFAELSSVCSGVCADESTLCMALLQLQRDKQVTVSLHDGEKVVKFCQHGQDRVSPVSDVDVGIY
D_melanogaster_FBpp0087704 ----------------------------------------------------------------------------------------------------------GKKEVAPTTGEAIQ
T_guttata_ENSTGUP00000017567 GVFILKPLKWTLSSVLGDSKIPEEEEVLIYVELLQEKAEEVYRLYQSSALSSHPVVALSELRSLCAGLCPDERTFYLLLLQLQKEKRVTILEQNGEKIVKFARGLHAKVSPMNDVDIGVY
O_latipes_ENSORLP00000013553 ---------------------------------------------------------------------------------------------------------HHRSKGGPSAQEAIH
T_nigroviridis_ENSTNIP00000009347 --------------------------------------------------------------------------------------------------------SGGKSGKQPTPQEAIQ
H_sapiens_ENSP00000324205 ---------------------------------------------------------------------------------------------------------KGKKEKGPTPEEAIQ
P_troglodytes_ENSPTRP00000010536 ---------------------------------------------------------------------------------------------------------KGKKEKGPTPEEAIQ
G_gorilla_ENSGGOP00000015698 ---------------------------------------------------------------------------------------------------------KGKKEKGPTPEEAIQ
C_elegans_R12C12.5 --------------------------------------------------------------------------------------------------------EKSRKRKAPTADEAIG
T_rubripes_ENSTRUP00000021743 --------------------------------------------------------------------------------------------------------HHHRSHAGPTPQEAIH
G_gallus_ENSGALP00000040164 GVFILKPLKWTLSSVLGDSKVPEEEEVLIYVELLQEKAEEVYRLYQNSVLSSHPVVALSELRSLCAGVCPDERTFYLLLLQLQKEKKVTILEQNGEKIVKFARGLHAKVSPMNDVDIGVY
250 260 270 280 290 300 310 320 330 340 350 360
=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000223500 TVDSRAESIDKKISRLDAELVKYKDQIKKM-----REGPAKNMVKQ-KALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKT-TVDAMKLGVKEMKKAYKQVKIDQIEDLQDQL
M_mulatta_ENSMMUP00000026530 TVDSRAESIDKKISRLDAELVKYKDQIKKM-----REGPAKNMVKQ-KALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKT-TVDAMKLGVKEMKKAYKQVKIDQIEDLQDQL
P_pygmaeus_ENSPPYP00000021442 TVDSRAESIDKKISRLDAELVKYKDQIKKM-----REGPAKNMVKQ-KALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKT-TVDAMKLGVKEMKKAYKQVKIDQIEDLQDQL
C_familiaris_ENSCAFP00000002699 TVDSRAESIDKKISRLDAELVKYKDQIKKM-----REGPAKNMVKQ-KALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKT-TVDAMKLGVKEMKKAYKQVKIDQIEDLQDQL
M_musculus_ENSMUSP00000030128 TVDSRAESIDKKISRLDAELVKYKDQIKKM-----REGPAKNMVKQ-KALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKT-TVDAMKLGVKEMKKAYKEVKIDQIEDLQDQL
R_norvegicus_ENSRNOP00000011907 TVDSRAESIDKKISRLDAELVKYKDQIKKM-----REGPAKNMVKQ-KALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKT-TVDAMKLGVKEMKKAYKEVKIDQIEDLQDQL
O_cuniculus_ENSOCUP00000007728 TVDSRAESIDKKISRLDAELVKYKDQIKKM-----REGPAKNMVKQ-KALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKT-TVDAMKLGVKEMKKAYKQVKIDQIEDLQDQL
M_domestica_ENSMODP00000004938 TVDSRAESIDKKISRLDSELVKYKDQIKKM-----REGPAKNMVKQ-KALRVLKQKRMYEQQRDNLSQQSFNMEQANYTIQSLKDTKT-TVDAMKLGVKEMKKAYKQVKIDQIEDIQDQL
B_taurus_ENSBTAP00000016431 TVDSRAESIDKKISRLDAELVKYKDQIKKM-----REGPAKNMVKQ-KALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKT-TVDAMKLGVKEMKKAYKQVKIDQIEDLQDQL
A_carolinensis_ENSACAP00000009586 TVDSRAESIDKKISRLDAELVKYKDQMKKM-----REGPAKNMVKQ-KALRVLKQKRMYENQRDNLAQQSFNMEQANYTIQSLKDTKT-TVDAMKVGVKEMKKAYKQVKIDHIEDLQDQL
G_gallus_ENSGALP00000021459 TVDSRAESIDKKIARLDAELVKYKDQMKKM-----REGPAKNTVKQ-KALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQALKDTKT-TVDAMKLGVKEMKKAYKQVKIDQIEDIQDQL
T_guttata_ENSTGUP00000008472 KVDSRAESIDKKIARLDAELVKYKDQMKKM-----REGPAKNTVKQ-KALRVLKQKRMYEQQRDNLSQQSFNMEQANYTIQALKDTKT-TVDAMKLGVKEMKKAYKQVKIDQIEDIQDQL
E_caballus_ENSECAP00000007753 LVDSRAESIDKKISRLDAELVKYKDQIKKM-----REGPAKNMVKQ-KALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKT-TVDAMKLGVKEMKKAYKQVKIDQIEDLQDQL
O_latipes_ENSORLP00000014308 NVDSRTESVDKKIARLDAELVKYKDQMKKM-----RDGPSKNMVKQ-KAMRVLKQKRMYEGQRDNLMQQSFNMEQANYTIQTLKDTKT-TVDAMKTGLKEMKKAYKQVKIDKIEDIQDQL
P_troglodytes_ENSPTRP00000035664 -VDSRAESIDKKISRLDAELVKYKDQIKKM-----REGPAKNMVKQ-KALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKT-TVDAMKLGVKEMKKAYKQVKIDQIEDLQDQL
O_latipes_ENSORLP00000022332 TVDARSESIEKKIGRLDAELLKYKDQLKKM-----RDGPSKNTVKQ-KAMRVLKQKRMYEGQREQLAQQSFNMEQANYTIQTLKDTKT-TVEAMKIGAKEMKKAYKDVKLDQIDDLQDQL
T_rubripes_ENSTRUP00000016981 TVDSRTDSIDKKISKLDAELVKYKDQMKKM-----KDGPSKNMVKQ-RAMRILKQKKAYENQRDGLAQQSFNMEQANYTIQNLKDTKT-TVDAMKTGLKEMKKAYKKVDINKIEDIQDQL
G_aculeatus_ENSGACP00000005636 NVDSRSESVDKKIARLDVELVKYKDQMKKM-----RDGPSKNMVKQ-KALRVLKQKRMYEGQRDNLMQQSFNMEQTNYTIQTLKDTKT-TVDAMKIGLKDMKKAYKHVKIDQIEDLQDEL
O_anatinus_ENSOANP00000005391 -VDSRAESIDKKIARLDAELVKYKDQIKKM-----REGPAKNMVKQ-KALRVLKQKRMYEQQRDNLSQQSFNMEQANYTIQSLKDTKT-TVDAMKLGVKEMKKAYKQVKIDQIEDIQDQL
G_aculeatus_ENSGACP00000022602 SVDARSESIEKKIGRLDAELVKYKDQMKKM-----REGPSKNMVKQ-KAMRVLKQKRMYEGQREQLAQQSFNMEQANYTIQTLKDTKT-TVEAMKIGAKEMKRAYKDVKLDQIDDLQDQL
D_rerio_ENSDARP00000061395 GVDSRAESVDKKIARLDAELMKYKDQMKKM-----RDGPSKNMVKQ-KAMRVLKQKRMYEGQRDQLMQQSFNMEQANYTIQTLKDTKT-TVEAMKIGAKEMKKAYKNVKIDQIEDLQDQL
T_rubripes_ENSTRUP00000028314 NVDARSESIEKKISRLDAELIKYKDQMKKM-----RDGPSKNMVKQ-KAMRVLKQKRMYEGQREQLAQQSFNMEQANYTIQTLKDTKT-TVEAMKIGAKEMKKAYKDVKLDQIDDLQDQL
G_gorilla_ENSGGOP00000016137 -VDSXAESIDKKISRLDAELVKYKDQIKKM-----REGPAKNMVKQ-KALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKT-TXXXXXXXVKEMKKAYKQVKIDQIEDLXDQL
D_rerio_ENSDARP00000056730 NVDTRIESIDKKIARIDAELMKYKDQMKKM-----RDGPSKNTVKQ-KAMRVLKQKRMYEGQRDQLSQQSFNMEQANYTIQSLRDTKT-TVEAMKIGAKEMKKAYKQVKMDQIEDLQDQL
M_mulatta_ENSMMUP00000038110 MVDGRAESTDKKISRLDTELVKCKDQI-KM-----RGGPAKNTVTQ-KALRVLKQKRMYEQQQENRTQQSFNTEQVNYTIQSLKDTKT-TADAMKLGAGEMK-AYN----DQIENLQDQV
T_nigroviridis_ENSTNIP00000021817 NVDARSESIEKKIARLDAELIKYKDQMKKM-----RDGPSKNMVKQ-KAMRVLKQKRMYEGQREQLAQQSFNMEQANYTIQTLKDTKT-TVEAMKIGAKEMKKAYKDVKLDQIDDLQDQL
X_tropicalis_ENSXETP00000010898 -VDSRSESIDKKISRLDAELVKYKDQMKKM-----REGPSKNMVKQ-KALRVLKQKRMYEQQRDNLNQQSFNMEQTNYAIQSLKDTKT-TVDAMKVGAKEMKKAYKQVKIDQIEDLQDQL
A_aegypti_AAEL005797-PA GVDSRAETIDQKVRTLDAELRKYKDQMAKM-----REGPAKNAVKA-KALRVLKQRKQYENQVENLRNQSFNMEQANFAAQTLKDTHA-TVAAMKDGMKSMKKEFKKINIEEIEDIQDDM
A_aegypti_AAEL012313-PA GVDSRAETIDQKVRTLDAELRKYKDQMAKM-----REGPAKNAVKA-KALRVLKQRKQYENQVENLRNQSFNMEQANFAAQTLKDTHA-TVAAMKDGMKSMKKEFKKINIEEIEDIQDDM
C_intestinalis_ENSCINP00000009854 SVDDRTESVEKKISKLDAELLKYRNQMKKM-----RPGPAKKAVQN-RALRVLKQKKMYETQRDNMMSQSFNMEQTNYSIQTIKDTKN-VVGAMKVGLKEMKKEHKKINLDEIEDLQDDM
R_norvegicus_ENSRNOP00000055831 TVDSRAESIDKKISLLDAELVKYKDQIKKM-----REG----------------QKRMCEQQRDNLTQQSFNTEQANYTIQSPEDTKT---DAMKLGVKGMKKAYKEVKIDQIEDLQGQL
A_gambiae_AGAP005100-PA GVDARAEAIEGKIKTLDNELRKYKDQMAKM-----REGPAKNAVKQ-KAMRVLKQRKQYESQVENLRNQSFNMEQANFAHQTLKDTQA-TVSAMKDGMKSMKKEFKKINIEEIEDIQDDM
D_melanogaster_FBpp0074964 GVDARATNIEEKISNLEAELRKYREQMSKM-----REGPAKNSVKQ-KALRVLKQKKAYEQQAESLRNQSFNMEQANYAAQSLKDTQA-TVAAMKDGVKQMKTEYKKINIDQIEDIQDDM
C_elegans_F41E6.9 NVESRSDSIDKKIQKLDQDLMKLRDQMSKM-----REGPSKNLIKQ-KALRVLKQKRMYENQKGQLDQQAFNMDQSNFAIQGMKDNQV-TVAAMKDGLKTMQKEYKKMNIDQIEDLQDQM
T_nigroviridis_ENSTNIP00000020259 NVDARSDSIDKKISKLDAELAKYKDQMKKM-----RDGPSKNMVKQ-KAMRVLKQKRMYESQRDNLMQQSFNMEQTNYTIQNLKDTKT-T------------------------------
S_cerevisiae_YDR486C SMNQAQQSLSNRISQLDTQIAQLNFQLQNIQKNLQRSNNKQPSLRK-QALKILNKRKQLENMKDSLDSQSWSMTQAQLTNDNLQNTMI-TINALKQTNNAMKAQYGKINIDKLQDMQDEM
C_intestinalis_ENSCINP00000022555 KLRDTAEMLQKKSEHLEVKI---ERELKTA-----KQHGTKN--KK-MAIAALKRKKRFEKQLQNVDGTLSTVELQLEAVQNAESNKL-VLDTMKTGAQALKQAHNHMNADEVHDVMDEI
C_intestinalis_ENSCINP00000029640 KLRDTAEMLQKKSEHLEVKI---ERELKTA-----KQHGTKN--KK-MAIAALKRKKRFEKQLQNVDGTLSTVELQLEAVQNAESNKL-VLDTMKTGAQALKQAHNHMNADEVHDVMDEI
S_cerevisiae_YMR077C EVKRSKDEIHKFTRRTDNLILVEKSQLKDL----IRKNPENYKSNM-KVRFLLKRIHYQEHLLQQASDQLINLENMVSTLEFKMVEKQ-FINGLKNGNEILKKLNKE--FSNVDELMDDV
T_nigroviridis_ENSTNIP00000014973 KLRETEEMLTKKQEFLEKKI---EQELQTA-----KKNGTKN--KR-AALQALKRKKRYEKQLAQIDGTLSTIEFQREALENANTSTE-VLKNMSFAAKALKSAHQDLDIDKVDDLMQDI
T_rubripes_ENSTRUP00000042469 QLQRSEKLLGERVERLELEAHKCKEEAKML----LREGK-----KS-QALRCLRGRKRVEKRAENLLAKVESIREILDRIAQSQTDKM-VIQAYQAGVSALKLSLKDVTVERAENLVDQI
D_melanogaster_FBpp0087704 KLRETENMLIKKQEFLEAKI---EDELNIA-----RKNASKN--KR-VALQALKKKKRLEKQLQQIDGTLSTIEMQREALESANTNTA-VLTTMKNAADALKRAHQNMDVDKVHDMMDDI
T_guttata_ENSTGUP00000017567 QLMQSEQLLSQKVESLSQEAEKCKEDARSA----CRAGK-----KQ-LALRCLKSKRRTERRIAELHSKLDAVQGILDRIYASQTDQM-VFNAYQAGVGALKLSMKDVTVERAENLVDQI
O_latipes_ENSORLP00000013553 RLRETEEMLTKKQEYLEKKI---EQEIATA-----KKHGTKN--KR-AALQALKRKKRLEQQLAQIDGTLSTIEFQREALENSHTNTE-VLKNMGFAAKAMKQVHQNMDLDKIDDLMQDI
T_nigroviridis_ENSTNIP00000009347 RLRETEEMLTKKQEFLEKKI---DQELLTA-----KKNGTKN--KR-AALQALKRKKRYEQQLNQIDGTLSTIEFQREALENANTNTE-VLKNMGMAAKAMKQAHHNIGVDNIDDLMADI
H_sapiens_ENSP00000324205 KLKETEKILIKKQEFLEQKI---QQELQTA-----KKYGTKN--KR-AALQALRRKKRFEQQLAQTDGTLSTLEFQREAIENATTNAE-VLRTMELAAQSMKKAYQDMDIDKVDELMTDI
P_troglodytes_ENSPTRP00000010536 KLKETEKILIKKQEFLEQKI---QQELQTA-----KKYGTKN--KR-AALQALRRKKRFEQQLAQTDGTLSTLEFQREAIENATTNAE-VLRTMELAAQSMKKAYQDMDIDKVDELMTDI
G_gorilla_ENSGGOP00000015698 KLKETEKILIKKQEFLEQKI---QQELQTA-----KKYGTKN--KR-AALQALRRKKRFEQQLAQTDGTLSTLEFQREAIENATTNAE-VLRTMELAAQSMKKAYQDMDIDKVDELMTDI
C_elegans_R12C12.5 NLRDAEELLIKKQEYFELRI---EQEVESA-----KKYMKTN--KK-MALAALRKKKHYEQELSRIDGVLTKLEAQRTALENVGMHNE-VIDVLGKTTETLKKEHAKMDIDKVHDLMDEI
T_rubripes_ENSTRUP00000021743 KLRETEEMLTKKQDFLEKRI---EQELMTA-----KKHGTKN--KQAAALRALKKKKRLEQQLVQIDGTLSTIEFQREALENSHTNTE-VLKNMGFAARALEKVHKDINIDKIDDMMQDI
G_gallus_ENSGALP00000040164 QLMQSEQLLSQKVESLSQEAEKCKDDARSA----CRAGK-----KQ-LALRCLKSKRRTERRIEELHSKLDAVQGILDRIYASQTDQMVVFNAYQAGVGALKLSMKDVTVEKAENLVDQI
370 380 390 400 410 420 430 440 450 460 470 480
=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000223500 EDMMEDANEIQEALSRS-YGT---PELDEDDLEA--ELDALGDEL---------LADEDSSYLDEAAS-----APAIPEGV----------PT-DTK------------------NKDGV
M_mulatta_ENSMMUP00000026530 EDMMEDANEIQEALSRS-YGT---PELDEDDLEA--ELDALGDEL---------LADEDSSYLDEAAS-----APAIPEGV----------PT-DTK------------------NKDGV
P_pygmaeus_ENSPPYP00000021442 EDMMEDANEIQEALSRS-YGT---PELDEDDLEA--ELDALGDEL---------LADEDSSYLDEAAS-----APAIPEGV----------PT-DTK------------------NKDGV
C_familiaris_ENSCAFP00000002699 EDMMEDANEIQEALSRS-YGT---PELDEDDLEA--ELDALGDEL---------LADEDSSYLDEAAS-----APAIPEGV----------PT-DTK------------------NKDGV
M_musculus_ENSMUSP00000030128 EDMMEDANEIQEALGRS-YGT---PELDEDDLEA--ELDALGDEL---------LADEDSSYLDEAAS-----APAIPEGV----------PT-DTK------------------NKDGV
R_norvegicus_ENSRNOP00000011907 EDMMEDANEIQEALGRS-YGT---PELDEDDLEA--ELDALGDEL---------LADEDSSYLDEAAS-----APAIPEGV----------PT-DTK------------------NKDGV
O_cuniculus_ENSOCUP00000007728 EDMMEDASEIQEALSRS-YGT---PELDEDDLEA--ELDALGDEL---------LADEDSSYLDEAAS-----APAIPEGV----------PT-DTK------------------NKDGV
M_domestica_ENSMODP00000004938 EDMMEDANEIQEALSRS-YGT---PEIDEDDLEA--ELDALGDEL---------LADEDSSYLDEAAS-----APAIPEGV----------PS-DAK------------------NKDGV
B_taurus_ENSBTAP00000016431 EDMMEDANEIQEALSRS-YGT---PELDEDDLEA--ELDALGDEL---------LADEDSSYLDEAAA-----APAIPEGV----------PT-DTK------------------NKDGV
A_carolinensis_ENSACAP00000009586 EDMMEDASEIQEALGRS-YGT---PEIDEDDLEA--ELEALGDEL---------LADEDSSYLDEAAS-----VPAIPEGM----------PT-EAK------------------NKDGV
G_gallus_ENSGALP00000021459 EDMMEEANEVQEALSRS-YGT---PEIDEDDLEA--ELDALGDEL---------LADEDNSYLDEAAS-----APAIPEGT----------PV-DTK------------------NKDGV
T_guttata_ENSTGUP00000008472 EDMMEEANEVQEALSRS-YGT---PDIDEDDLEA--ELDALGDEL---------LADEDNSYLDEAAS-----APAIPEVT----------PT-DTK------------------NKDGV
E_caballus_ENSECAP00000007753 EDMMEDANEIQEALSRS-YGT---PELDEDDLEA--ELDALGDEL---------LADEDSSYLDEAAS-----APAIPEGV----------PT-DTK------------------NKDGV
O_latipes_ENSORLP00000014308 EDMMEDANEIQEAMGRS-YGT---PEIDEDDLEA--ELDALGDEL---------LMDDDSSYLDEAAT-----APSIPEGN----------PG-DRT-----------------ANRDGV
P_troglodytes_ENSPTRP00000035664 EDMMEDANEIQEALSRS-YGT---PELDEDDLEA--ELDALGDEL---------LADEDSSYLDEAAS-----APAIPEGV----------PT-DTK------------------NKDGV
O_latipes_ENSORLP00000022332 EDMMEEAGEVQESLSRS-YGT---PDIDEEDLEA--ELDALGDEL---------LLDEDSSYLDEASA-----APSIPEGI----------PS-DSK-----------------TNKDGV
T_rubripes_ENSTRUP00000016981 EDMMEDANDIQDALGRS-YGT---PDIDEADLEAGTELDALGDEL---------LFDDDSTYLDEAST-----APSIPEGI----------PG-DKS-----------------TNRDGV
G_aculeatus_ENSGACP00000005636 GDMMEDANDIQEALGRS-YGT---PELDDDDLEA--ELDALGDEL---------LMDDDSSYLDEAAT-----APSIPEGM----------PG-DKS-----------------VNRDGV
O_anatinus_ENSOANP00000005391 EDMMEDANEIQEALSRS-YGT---PEIDEDDLEA--ELDALGDEL---------LADEDTSYLDEAAS-----APAIPEGA----------PT-DAK------------------NKDGV
G_aculeatus_ENSGACP00000022602 EDMMEDAGEVQEALSRS-YGT---PEIDEDDLEA--ELDALGDEL---------LLDDDSSYLDEASA-----APSIPEGI----------PS-DSK-----------------TNKDGV
D_rerio_ENSDARP00000061395 EDMMEDANEVQEALSRS-YGT---PEIDEDDLEAAKELDALGDEL---------LLDDDNSYLDEASS-----APAIPEGA----------PG-DRT-----------------TNRDGV
T_rubripes_ENSTRUP00000028314 EDMMDEANDVQEALSRS-YGT---PDIDEDDLEA--ELDALGDEL---------LLDDDSSYLDEASA-----APSIPEGI----------PS-DSK-----------------TNKDGV
G_gorilla_ENSGGOP00000016137 EDMMEDANEIQEAXSRS-YGT---PELDEDDLEA--ELDALGDEL---------LADEDSSYLDEAAS-----APAIPEGV----------PT-DTK------------------NKDGV
D_rerio_ENSDARP00000056730 EDMMEEANEVQEALSRS-YGT---PEIDEDELEA--ELDALGDEL---------LLDDDSSYLDEASS-----APSIPEGM----------PS-DTK-----------------TNKDGV
M_mulatta_ENSMMUP00000038110 VDMMEDANEIQEALSRS-YGG---PEFNEDDLEA--ELD-LGDEL---------VADKD-SYLDEAVS-----APAIPTQK----------TN------------------------DGV
T_nigroviridis_ENSTNIP00000021817 EDMMDEANEVQEALSRS-YGT---PDIDEDDLEA--ELDALGDEL---------LLDDDSSYLDEASA-----APSIPEGI----------PN-DSK-----------------TNK---
X_tropicalis_ENSXETP00000010898 EDMMENANEIQEALSRS-YGT---PEIDEDDLEA--ELDALGDEL---------LLDDDTSYLDEAAS-----APAIPEGV----------PN-DSK------------------NKVGF
A_aegypti_AAEL005797-PA ADMLEQADEVQEAMGRS-YGM---PEIDDDELQA--ELDALGDEI---------ALDDDTSYLDDVVK-----APAAPDKE----------PG-ADS----------------VTNKDGI
A_aegypti_AAEL012313-PA ADMLEQADEVQEAMGRS-YGM---PEIDDDELQA--ELDALGDEI---------ALDDDTSYLDDVVK-----APAAPDKE----------PG-ADS----------------VTNKDGI
C_intestinalis_ENSCINP00000009854 ADMLEMSEEIQETLGRS-YGT---PELDEDDLEA--ELDALGDDM---------FEDE---FLGDEVA-----APNAPSNA----------IG-DSV----------------PANSEGV
R_norvegicus_ENSRNOP00000055831 EDMVEDANGIQEAPGRS-HGT---P-LDEDDQEA--ELMRRATSF---------WLMTTALNLDQAAS-----ALAIPEGV----------PT-DTK---------------------DK
A_gambiae_AGAP005100-PA ADMLEQADEVQEAMGRT-YGM---PELDDDELQA--ELDALGDEI---------ALDDDASYLDDVVK-----APEAPDKE----------PG-ADS----------------VTNKDGI
D_melanogaster_FBpp0074964 ADMFEQADEVQEALGRT-YGM---PEVDDDDLQA--ELDALGDEI---------ALDDDTSYLDDVVK-----APEAPSRE----------PG-ADS---------------IVPGKSTI
C_elegans_F41E6.9 EDMLDMNNEIQEAMSRQ-YDT---PDIDEADLEA--ELAMLGDEL--------DIGESDTNYLDEALA-----APTVPSDK----------PK-TRV-------------------AEGL
T_nigroviridis_ENSTNIP00000020259 ------------------------------------------------------------------------------------------------------------------------
S_cerevisiae_YDR486C LDLIEQGDELQEVLAMN-NNSGELDDISDAELDA--ELDALAQEDFTLPTSENSLGNDMPSYLLGANA-----PPAFIDEE----------PN-LDT-----------------EDKNKA
C_intestinalis_ENSCINP00000022555 DEQKVISDEITTALSGG-FGY---QDVDEDDLMA--ELEELEQEE----------FNENMLDIPAAEE-----LPDVPTHS----------LP-QPA-----------------------
C_intestinalis_ENSCINP00000029640 DEQKVISDEITTALSGG-FGY---QDVDEDDLMA--ELEELEQEE----------FNENMLDIPAAEE-----LPDVPTHS----------LP-QPA-----------------KAKAKA
S_cerevisiae_YMR077C QDQIAYQNEINETLSRS-LVG---TSNYEDDLDK--ELDALESEL-----NPEKMNNAKVANMPSTEG-----LPSLPQGE----------QT-EQK-----------------EREEFA
T_nigroviridis_ENSTNIP00000014973 -EQQELAQEISDAISKP--GLG--EQFDEDDLLA--ELDELVQVE----------LDQNLLDIEGTGNVS---LPNVPSTS----------LP-SRP-----------------AIKAKK
T_rubripes_ENSTRUP00000042469 QELCDAQDDVNQTLSRG-VAG---AEGDMDELEE--ELKLLLDET----------KPDSISL-----------LPEVPSGAVKHPGGTGLLDSLPDAPHGPIGICEQLKQLSVTDAGGTG
D_melanogaster_FBpp0087704 AEQQDVAREISDAISNP-VAFG--ADLDDEDLER--ELDELEQEN----------FDKEIIGIPEPTPT----LPEAPTED----------LP-EKA----------KEKKKATTTTAVE
T_guttata_ENSTGUP00000017567 QELCDTQDEVAQTLAGVGING---LEVDSEELEK--ELDSLLQDS----------SKDSLD------------LPPVPQKV------PG--APISDAE-----LEAELEQLSVSAGDLAQ
O_latipes_ENSORLP00000013553 TEQQEVAQEISEAISRP-FG----DTFDEDELLA--ELEELEQQE----------LEDSMKNMGG--------LPNVPNSK----------LP-ARPGPRPRSMVGLESNRFCFAATKKR
T_nigroviridis_ENSTNIP00000009347 AEQHELAQEISDTISRP-VGPG--IDFDEDELLA--ELEEMEQEE----------LDKNLLEVEGPSSDP---LPNVPSTS----------LP-ARP-------------------AKKE
H_sapiens_ENSP00000324205 TEQQEVAQQISDAISRP-MGFG--DDVDEDELLE--ELEELEQEE----------LAQELLNVGDKEEEPSVKLPSVPSTH----------LP-AGP-------------------APKV
P_troglodytes_ENSPTRP00000010536 TEQQEVAQQISDAISRP-MGFG--DDVDEDELLE--ELEELEQEE----------LAQELLNVGDKEEEPPVKLPSVPSTH----------LP-AGP-------------------APKV
G_gorilla_ENSGGOP00000015698 TEQQEVAQQISDAISRP-MGFG--DDVDEDELLE--ELEELEQEE----------LAQELLNVGDKEEEPPVKLPSVPSTH----------LP-AGP-------------------APKV
C_elegans_R12C12.5 ADGLAMSEELNEAISAP-IG----DVADEDELMQ--ELQELQDNV---------------ADLSTTTK-----LPDVPAT-----------LP-EAP-----------SGELTRAGRRGK
T_rubripes_ENSTRUP00000021743 TEQQDRAQEISDAISRP-FG----DVYDEDELLA--ELQELQDQD----------MEESMESMGG--------LPSVPSSK----------LPSARP-----------SQHAYFPATRRR
G_gallus_ENSGALP00000040164 QELCDTQDEVAQTLAGAGVNG---LEMDSEELEK--ELDSLLQDS----------AKEPVH------------LHPVPQKD------SGFAGAISDAE-----LEAELEKLSVCDGDLAQ
490
=========+=======
H_sapiens_ENSP00000223500 LVDEFGLPQIPAS----
M_mulatta_ENSMMUP00000026530 LVDEFGLPQIPAS----
P_pygmaeus_ENSPPYP00000021442 LVDEFGLPQIPAS----
C_familiaris_ENSCAFP00000002699 LVDEFGLPQIPAS----
M_musculus_ENSMUSP00000030128 LVDEFGLPQIPAS----
R_norvegicus_ENSRNOP00000011907 LVDEFGLPQIPAS----
O_cuniculus_ENSOCUP00000007728 LVDEFGLPQIPAS----
M_domestica_ENSMODP00000004938 LVDEFGLPQIPAT----
B_taurus_ENSBTAP00000016431 LVDEFGLPQIPAS----
A_carolinensis_ENSACAP00000009586 LVDEFGLPQIPAT----
G_gallus_ENSGALP00000021459 LVDEFGLPKIPAT----
T_guttata_ENSTGUP00000008472 LVDEFGLPKIPAT----
E_caballus_ENSECAP00000007753 LVDEFGLPQIPAS----
O_latipes_ENSORLP00000014308 LVDEFGLPQIPAT----
P_troglodytes_ENSPTRP00000035664 LVDEFGLPQIPAS----
O_latipes_ENSORLP00000022332 LVDEFGLPQIPAT----
T_rubripes_ENSTRUP00000016981 LVDEFGLPQIPAS----
G_aculeatus_ENSGACP00000005636 LVDEFGLPQIPAT----
O_anatinus_ENSOANP00000005391 LVDEFGLPQIPAT----
G_aculeatus_ENSGACP00000022602 LVDEFGLPQIPAS----
D_rerio_ENSDARP00000061395 LVDEFGLPQIPAT----
T_rubripes_ENSTRUP00000028314 LVDEFGLPQIPAS----
G_gorilla_ENSGGOP00000016137 LVDEFGLPQIPAS----
D_rerio_ENSDARP00000056730 LVDEFGLPQIPAT----
M_mulatta_ENSMMUP00000038110 LVDEFGLPQIPASYICI
T_nigroviridis_ENSTNIP00000021817 -----------------
X_tropicalis_ENSXETP00000010898 L----------------
A_aegypti_AAEL005797-PA LVDEFGLPQIPTQVKST
A_aegypti_AAEL012313-PA LVDEFGLPQIPTQVKST
C_intestinalis_ENSCINP00000009854 PVDEFGLPQLPA-----
R_norvegicus_ENSRNOP00000055831 LVDEFGLPQIPAL----
A_gambiae_AGAP005100-PA LVDEFGLPKIPASVKTT
D_melanogaster_FBpp0074964 ETDEFGLPKIPTSLKTT
C_elegans_F41E6.9 EVDEFGLPKLPA-----
T_nigroviridis_ENSTNIP00000020259 -----------------
S_cerevisiae_YDR486C LESAQ------------
C_intestinalis_ENSCINP00000022555 -----------------
C_intestinalis_ENSCINP00000029640 KEDDDELAELQMWAS--
S_cerevisiae_YMR077C TEERSDTKEPLALLS--
T_nigroviridis_ENSTNIP00000014973 EEDEDDMEDLQRWAMEA
T_rubripes_ENSTRUP00000042469 AAGLAAARQIQETSRPA
D_melanogaster_FBpp0087704 DDDDPDMKQLLSWSN--
T_guttata_ENSTGUP00000017567 KTPSASSEPKTALGLNL
O_latipes_ENSORLP00000013553 VEDDDDMHMLASWAT--
T_nigroviridis_ENSTNIP00000009347 EEEEDDMADLQAWAIS-
H_sapiens_ENSP00000324205 DEDEEALKQLAEWVS--
P_troglodytes_ENSPTRP00000010536 DEDEEALKQLAEWVS--
G_gorilla_ENSGGOP00000015698 DEDEEALKQLAEWVS--
C_elegans_R12C12.5 FRKMSTMEELEQWAASN
T_rubripes_ENSTRUP00000021743 AEEDEDLSKLASWAI--
G_gallus_ENSGALP00000040164 KTPSASSEPQTALGLNL