10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000226574 -----------------------------------------------------------------------------------------------MAEDDPYLGR--PEQMFHLDPSL-T P_troglodytes_ENSPTRP00000028033 -----------------------------------------------------------------------------------------------MAEDDPYLGR--PEQMFHLDPSL-T M_mulatta_ENSMMUP00000034946 -----------------------------------------------------------------------------------------------MAEDDPYLGR--PEQMFHLDPSL-T P_pygmaeus_ENSPPYP00000016712 -----------------------------------------------------------------------------------------------MAEDDPYLGR--PEQMFHLDPSL-T C_familiaris_ENSCAFP00000015815 -----------------------------------------------------------------------------------------------MAEDDTYLGA--HEQMFHLDP-L-T B_taurus_ENSBTAP00000027016 -----------------------------------------------------------------------------------------------MAEDDPYLGG--HEQMFHLDP-L-N E_caballus_ENSECAP00000013133 -----------------------------------------------------------------------------------------------MAEDDPYLGG--HEQMFHLES-L-N M_musculus_ENSMUSP00000029812 -----------------------------------------------------------------------------------------------MADDDPY--G--TGQMFHLNTAL-T R_norvegicus_ENSRNOP00000028944 -----------------------------------------------------------------------------------------------MADDDPF--G--TGQMFHLNTAL-T M_domestica_ENSMODP00000025861 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000003727 --------------------------------------------------------------------------------------------GLKMAAEDSYIMGVSDPQMFTVDQFMGM G_gallus_ENSGALP00000020084 --------------------------------------------------------------------------------------------GLKMAGEDPYIMGVSDPQMFAMDQLMGM A_carolinensis_ENSACAP00000015967 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000046127 ------------------------------------------------------------------------------------------------------MAQNIYDIDAHLDTYLPI T_nigroviridis_ENSTNIP00000005249 ----------------------------------------------------------------------------------------------MAADEHYLHASNQIFDLPMLDAPW-- G_aculeatus_ENSGACP00000022290 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008878 -----------------------------------------------------------------------------------------------MAEDDPYLGR--PEQMFHLDPSL-T T_rubripes_ENSTRUP00000010369 ---------------------------------------------------------------------------------------------------------------------FWT G_aculeatus_ENSGACP00000001732 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000014173 -----------------------------------------------------------------------------------------------------------------LDG-LDY T_guttata_ENSTGUP00000007782 -----------------------------------------------------------------------------------------------------------------LDG-IDY C_familiaris_ENSCAFP00000014918 ---------------------------------------------------------------------------------------------------------MESCYDPGLDGMIEY M_musculus_ENSMUSP00000072859 ---------------------------------------------------------------------------------------------------------MDNCYDPGLDGIPEY B_taurus_ENSBTAP00000007904 ---------------------------------------------------------------------------------------------------------MDSCYDPGLDGIIEY M_mulatta_ENSMMUP00000003997 ---------------------------------------------------------------------------------------------------------MESCYNPGLDGIIEY E_caballus_ENSECAP00000017595 ---------------------------------------------------------------------------------------------------------MESCYDPGLDGIIDY H_sapiens_ENSP00000358983 ---------------------------------------------------------------------------------------------------------MESCYNPGLDGIIEY T_nigroviridis_ENSTNIP00000016350 -------------------------------------------------------------------------------------------------------------IDPRLQLQMNL R_norvegicus_ENSRNOP00000026235 ---------------------------------------------------------------------------------------------------------MDRCYDPGLDGIPEY O_latipes_ENSORLP00000003676 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000057671 --------------------------------------------------------------------------------------------MAGALRMDDTHYQIGFVVNEPMTFPSAY D_rerio_ENSDARP00000056498 --------------------------------------------------------------------------------------------MAGALRMDDTHYQIGFVVNEPMTFPSAY P_pygmaeus_ENSPPYP00000003023 ---------------------------------------------------------------------------------------------------------MESCYNPGLDGIIEY X_tropicalis_ENSXETP00000000018 --------------------------------------------------------------------------------------------MMSALKIENFD-------PYSCNGIEES C_intestinalis_ENSCINP00000014252 -----------------------------------------------------------------------------------------------------------------------M P_troglodytes_ENSPTRP00000005089 ---------------------------------------------------------------------------------------------------------MESCYNPGLDGIIEY G_gorilla_ENSGGOP00000006827 ---------------------------------------------------------------------------------------------------------MESCYNPGLDGIIEY O_cuniculus_ENSOCUP00000004978 ---------------------------------------------------------------------------------------------------------MESCYDPSLDGIIEY A_aegypti_AAEL007624-PA MSTLLNLDSYRHELFEHHQHQQQHHQLQQLSSSP-TYSVLSMESVSPVSSSSA-------------------------SPAADTSKYYASNSPSSVSNMSPKSTASDTS-SFNMQNLNIS M_mulatta_ENSMMUP00000037540 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000011996 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000019655 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000003533 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000384273 ----------SGEWLVCSARRGPSCDPGPAPGTPA------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000044552 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000011798 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000018453 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000006707 ----------SGEWLVCSARRGPSCDPGPAPGTPA------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000055326 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000025867 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000006862 --------------------------------------SAPASGPSVPTGRAMPSRRVARPSAAPELGALGSTDLS--SLAVSRTTVPTEIIDEYIKENGFGLEGAQLGPGEGLPRLVSR B_taurus_ENSBTAP00000049624 -----------------------------------VFWSGLASGPSVPTGWAMPSRRVARSSAAPELGPLGSADLSSLSLAVSRTTDELEIIDEYIKENGFGLEGAQPGP-EGLPRLVSR D_melanogaster_FBpp0088375 ----------MNMNQYYDLDNGKNVMFMNDASSTSGYSSSTSPNSTNRSFSPAHSPKTMELQTDFANLNLPGGNSPHQPPMANSPYQNQLLNNGGICQLGATNLINSTGVSFGVANVTSF A_aegypti_AAEL006930-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP006747-PA MSTLLNLDSYRHELYE---------QQQLLGTSPIQYTVLSMDTPSPSSSSAAAAVVSVGEFTLGPGRTYASALSPSSSSASPSSPSSVASPNSRASNMSPESSASDQSAAYTLQNLNLS 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000226574 HTI------------------------------------FNPEVF-QP--QM-----------------ALPTADGPYLQILEQPKQRGFRFRYVCE-GPSHGGLPGASSEKNKKSYPQV P_troglodytes_ENSPTRP00000028033 HTI------------------------------------FNPEVF-QP--QM-----------------ALPTADGPYLQILEQPKQRGFRFRYVCE-GPSHGGLPGASSEKNKKSYPQV M_mulatta_ENSMMUP00000034946 HTI------------------------------------FNPEVF-QP--QM-----------------ALPTADGPYLQILEQPKQRGFRFRYVCE-GPSHGGLPGASSEKNKKSYPQV P_pygmaeus_ENSPPYP00000016712 HTI------------------------------------FNPEVF-QP--QM-----------------ALPT-DGPYLQILEQPKQRGFRFRYVCE-GPSHGGLPGASSEKNKKSYPQV C_familiaris_ENSCAFP00000015815 HTI------------------------------------FNPELF-QP--EM-----------------PLPTADGPYLQILEQPKQRGFRFRYVCE-GPSHGGLPGASSEKNKKSYPQV B_taurus_ENSBTAP00000027016 HTM------------------------------------FSPELF-QP--EM-----------------PLPTADGPYLQILEQPKQRGFRFRYVCE-GPSHGGLPGASSEKNKKSYPQV E_caballus_ENSECAP00000013133 HTM------------------------------------FNPELF-TQ--EV-----------------SLPT-DGPYLQILEQPKQRGFRFRYVCE-GPSHGGLPGASSEKNKKSYPQV M_musculus_ENSMUSP00000029812 HSI------------------------------------FNAELY-SP--EI-----------------PLST-DGPYLQILEQPKQRGFRFRYVCE-GPSHGGLPGASSEKNKKSYPQV R_norvegicus_ENSRNOP00000028944 HSI------------------------------------FNAELY-ST--DI-----------------PLST-DGPYLQILEQPKQRGFRFRYVCE-GPSHGGLPGASSEKNKKSYPQV M_domestica_ENSMODP00000025861 -------------------------------------------------------------------------ADGPYLQILEQPKQRGFRFRYVCE-GPSHGGLPGASSEKNKKSYPQV T_guttata_ENSTGUP00000003727 NAL------------------------------------FNSTNYITA--DL-----------------PLRTADGPYLQIIEQPKQRGFRFRYVCE-GPSHGGLPGASSEKNKKSYPQV G_gallus_ENSGALP00000020084 STI------------------------------------FNNTGYITS--DL-----------------PLRTADGPYLQIIEQPKQRGFRFRYVCE-GPSHGGLPGASSEKNKKSYPQV A_carolinensis_ENSACAP00000015967 -------------------------------------------------------------------------ADGPYLQIVEQPKQRGFRFRYVCE-GPSHGGLPGASSEKNKKSYPQV X_tropicalis_ENSXETP00000046127 NPL------------------------------------FQEPIYMTS--EP-----------------NLRSAEGPYIEITEQPKQRGFRFRYVCE-GPSHGGLPGASSEKNKKSYPQI T_nigroviridis_ENSTNIP00000005249 --------------------------------------DFTPFPAMAQ--AP-----------------SLRTVDGPFLQIVEQPKQRGFRFRYGCE-GPSHGGLPGASSEKNRNTYPTI G_aculeatus_ENSGACP00000022290 --------------------------------------------------------------------------DGPFLQIVEQPKQRGFRFRYGCE-GPSHGGLPGASSEKTSKTYPAV G_gorilla_ENSGGOP00000008878 HTI------------------------------------FNPEVF-QP--QM-----------------ALPTADGPYLQILEQPKQRGFRFRYVCE-GPSHGGLPGASSEKNKKSYPQV T_rubripes_ENSTRUP00000010369 DGF-----------------------------------HLRPERSVLHKLPS-SLTLLIWNSWGFSYTWPLPGTHGPYIQIIEEPKQRGFRFRYECE-GPSHGGLPGASSEKNRRTYPTV G_aculeatus_ENSGACP00000001732 --------------------------------------------------PS-----------------SGVSAHGPYIQIIEEPKQRGFRFRYECE-GPSHGGLPGASSEKNRRTYPTV A_carolinensis_ENSACAP00000014173 DDF-----------------------------------QFGSHLIEQK--EL-----------------HMETAEGPFLTIIEQPKQRGFRFRYGCE-GPSHGGLPGASSEKGHKTYPTV T_guttata_ENSTGUP00000007782 DDF-----------------------------------SFGSHMMEQK--EP-----------------LMETVEGPYLVIIEQPKQRGFRFRYGCE-GPSHGGLPGASSEKGRKTYPTV C_familiaris_ENSCAFP00000014918 DDF-----------------------------------KFDPCIAEPK--EP-----------------APETADGPYLVIVEQPKQRGFRFRYGCE-GPSHGGLPGASSEKGRKTYPTV M_musculus_ENSMUSP00000072859 DDF-----------------------------------EFSPSIVEPK--DP-----------------APETADGPYLVIVEQPKQRGFRFRYGCE-GPSHGGLPGASSEKGRKTYPTV B_taurus_ENSBTAP00000007904 DDF-----------------------------------KFNPSIVEPK--EP-----------------APETADGPYLVIVEQPKQRGFRFRYGCE-GPSHGGLPGASSEKGRKTYPTV M_mulatta_ENSMMUP00000003997 DDF-----------------------------------KLNSSIMEPK--EP-----------------APETADGPYLVIVEQPKQRGFRFRYGCE-GPSHGGLPGASSEKGRKTYPTV E_caballus_ENSECAP00000017595 DDF-----------------------------------KFNPSIVEPK--EP-----------------APETADGPYLVIVEQPKQRGFRFRYGCE-GPSHGGLPGASSEKGRKTYPTV H_sapiens_ENSP00000358983 DDF-----------------------------------KLNSSIVEPK--EP-----------------APETADGPYLVIVEQPKQRGFRFRYGCE-GPSHGGLPGASSEKGRKTYPTV T_nigroviridis_ENSTNIP00000016350 MQY-----------------------------------DYIPRV-DIKTEPY-----------------IPETAHGPYIQIIEEPKQRGFRFRYECE-GPSHGGLPGASSEKNRRTYPTV R_norvegicus_ENSRNOP00000026235 DDF-----------------------------------EFSPSIVEPK--DP-----------------APETADGPYLVIVEQPKQRGFRFRYGCE-GPSHGGLPGASSEKGRKTYPTV O_latipes_ENSORLP00000003676 ---------------------------------------------------------------------------GPYIQIIEEPKQRGFRFRYECE-GPSHGGLPGASSEKNRRTYPTV D_rerio_ENSDARP00000057671 DDL-----------------------------------PYMPEAFEVKHEPF-----------------VQETVDGPYIQIIEEPKQRGFRFRYECE-GPSHGGLPGASSERNRRTYPTV D_rerio_ENSDARP00000056498 DDL-----------------------------------PYMPEAFEVKHEPF-----------------VQETVDGPYIQIIEEPKQRGFRFRYECE-GPSHGGLPGASSERNRRTYPTV P_pygmaeus_ENSPPYP00000003023 DDF-----------------------------------KLNSSIVEHK--EP-----------------APETADGPYLVIVEQPKQRGFRFRYGCE-GPSHGGLPGASSEKGRKTYPTV X_tropicalis_ENSXETP00000000018 NGI-----------------------------------GYSSSLLDTR--VL-----------------GQDMANVAFLSIIEQPKQRTGAQNICCT-GLLY---LSTVLSKGNEVFRIN C_intestinalis_ENSCINP00000014252 SDQ-----------------------------------SLVLHQSTRE--NM-----------------FPEENGEPYLEIIENPKSRGFRFRYTCE-GPSHGGIPGGSSDKNKKTFPAV P_troglodytes_ENSPTRP00000005089 DDF-----------------------------------KLNSSIVEPK--EP-----------------APETADGPYLVIVEQPKQRGFRFRYGCE-GPSHGGLPGASSEKGRKTYPTV G_gorilla_ENSGGOP00000006827 DDF-----------------------------------KLNSSIVEPK--EP-----------------APETADGPYLVIVEQPKQRGFRFRYGCE-GPSHGGLPGASSEKGRKTYPTV O_cuniculus_ENSOCUP00000004978 EEF-----------------------------------KFDPSIVEPK--EP-----------------APETDDGPYLVIVEQPKQRGFRFRYGCE-GPSHGGLPGASSEKGRKTYPTV A_aegypti_AAEL007624-PA NAY--------------------------------PYFAETHHQTMTTGEEGQLQTFTYNDPTQ-----PRVELSVPQLTIVEQPVDK-FRFRYQSEMHGTHGSLMGVHTEKSKKTFPTV M_mulatta_ENSMMUP00000037540 -----------------------------------------LSELFPLIFPA-----------------EPAQASGPYVEIIEQPKQRGMRFRYKCE-GRSAGSIPGERSTDTTKTHPTI M_domestica_ENSMODP00000011996 -----------------------------------------FSGLLPMIFAS-----------------DSPPARGPFVEIIEQPKQRGMRFRYKCE-GRSAGSIPGERSTDTTKTHPTI C_familiaris_ENSCAFP00000019655 -----------------------------------------LSDLFPLIFPA-----------------EPAQASGPYVEIIEQPKQRGMRFRYKCE-GRSAGSIPGERSTDTTKTHPTI P_pygmaeus_ENSPPYP00000003533 -----------------------------------------MDELFPLIFPA-----------------EPAQASGPYVEIIEQPKQRGMRFRYKCE-GRSAGSIPGERSTDTTKTHPTI H_sapiens_ENSP00000384273 -----------------------------------------MDELFPLIFPA-----------------EPAQASGPYVEIIEQPKQRGMRFRYKCE-GRSAGSIPGERSTDTTKTHPTI R_norvegicus_ENSRNOP00000044552 -----------------------------------------LSDLFPLIFPS-----------------EPAQASGPYVEIIEQPKQRGMRFRYKCE-GRSAGSIPGERSTDTTKTHPTI E_caballus_ENSECAP00000011798 -----------------------------------------LSDLFPLIFPS-----------------EPAQASGPYVEIIEQPKQRGMRFRYKCE-GRSAGSIPGERSTDTTKTHPTI B_taurus_ENSBTAP00000018453 -----------------------------------------MDDLFPLIFPA-----------------EPAQASGPYVEIIEQPKQRGMRFRYKCE-GRSAGSIPGERSTDTTKTHPTI P_troglodytes_ENSPTRP00000006707 -----------------------------------------MDELFPLIFPA-----------------EPAQASGPYVEIIEQPKQRGMRFRYKCE-GRSAGSIPGERSTDTTKTHPTI X_tropicalis_ENSXETP00000055326 -----------------------------------------------------------------------MPSSHPHVEIIEQPKQRGMRFRYKCE-GRSAGSIPGERSTDTTKTHPTI M_musculus_ENSMUSP00000025867 -----------------------------------------MDDLFPLIFPS-----------------EPAQASGPYVEIIEQPKQRGMRFRYKCE-GRSAGSIPGERSTDTTKTHPTI C_familiaris_ENSCAFP00000006862 GAA-----------------------------------SLSTVTLGPPAPPPPATPPPWGCHLGRVMPQAPGPGPRPHLVITEQPKQRGMRFRYECE-GRSAGSILGESSTEASKTLPAI B_taurus_ENSBTAP00000049624 GAA-----------------------------------SLSTVTLGPAAPPPPATPPPWGCTLGRLVPPAAGAGPRPHLVITEQPKQRGMRFRYECE-GRSAGSILGESSTEASKTLPAI D_melanogaster_FBpp0088375 GNM-----------------------------------YMDHQYFVPA--PATVPPSQNFGYHQNGLASDGDIKHVPQLRIVEQPVEK-FRFRYKSEMHGTHGSLNGANSKRTPKTFPEV A_aegypti_AAEL006930-PA ---------------------------------------MLSHNLSGKEEQT-----------------VQKMAQKPYVVITEQPQSKALRFRYECE-GRSAGSIPGVSSTADHKTFPTI A_gambiae_AGAP006747-PA SSAGTMNYPGMGYQQQQQQQQQQQQHHQHQQLQQQQHHYYTPQLLNLDQEQLQTQTFTYVTSSNEAFAAPEPNYSEPHLVILEQPVDK-FRFRYQSEMHGTHGSLMGSRTEKSKKTFPTV 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000226574 KICNYVGPAKVIVQ--LVTN-GKNIH-LHAHSLVGKH-C-EDGICTVTAGPK-DM---------------------VVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLA P_troglodytes_ENSPTRP00000028033 KICNYVGPAKVIVQ--LVTN-GKNIH-LHAHSLVGKH-C-EDGICTVTAGPK-DM---------------------VVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLA M_mulatta_ENSMMUP00000034946 KICNYVGPAKVIVQ--LVTN-GKNIH-LHAHSLVGKH-C-EDGICTVTAGPK-DM---------------------VVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLA P_pygmaeus_ENSPPYP00000016712 KICNYVGPAKVIVQ--LVTN-GKNTH-LHAHSLVGKH-C-EDGICTVTAGPK-DM---------------------VVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLA C_familiaris_ENSCAFP00000015815 KICNYVGPAKVIVQ--LVTN-GKNIH-LHAHSLVGKH-C-EDGICTVTAGPK-DM---------------------VVGFANLGILHVTKKKVFETLEARMTEACTKGYNPGLLVHPDLA B_taurus_ENSBTAP00000027016 KICNYVGPAKVIVQ--LVTN-GKNIH-LHAHSLVGKH-C-EDGVCTVTAGPK-DM---------------------VVGFANLGILHVTKKKVFETLEARMTDACIRGYNPGLLVHPDLA E_caballus_ENSECAP00000013133 KICNYVGPAK-FVQ--LVTN-GKHTH-LHGSQSSGKNTV-KDGICTVTAGPK-DM---------------------VVGFANLGILHVTKKKVFETLEARMTEACVRGYNPEILVHPDLR M_musculus_ENSMUSP00000029812 KICNYVGPAKVIVQ--LVTN-GKNIH-LHAHSLVGKH-C-EDGVCTVTAGPK-DM---------------------VVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHSDLA R_norvegicus_ENSRNOP00000028944 KICNYVGPAKVIVQ--LVTN-GKNIH-LHAHSLVGKH-C-EDGICTVTAGPK-DM---------------------VVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHSDLA M_domestica_ENSMODP00000025861 KICNYVGPAKVIVQ--LVTN-GKHVH-LHAHSLVGKH-C-EDGICTVTAGPK-DM---------------------VVGFANLGILHVTKKKVYETLEARMTDACIRGYNPGLLVHPELN T_guttata_ENSTGUP00000003727 KICNYVGPAKVIVQ--LVTN-GKYVH-LHAHSLVGKF-C-EDGVCTVIAGPK-DM---------------------VVGFANLGILHVTKKKVLETLETRMIDACKKGYNPGLLVHPELS G_gallus_ENSGALP00000020084 KICNYVGPAKVIVQ--LVTN-GKYVH-LHAHSLVGKF-C-EDGVCTVNAGPK-DM---------------------VVGFANLGILHVTKKKVFETLETRMIDACKKGYNPGLLVHPELG A_carolinensis_ENSACAP00000015967 KICNYAGPAKVIVQ--LVTN-GKHVH-LHAHSLVGKH-C-EQGVCTVNAGPK-DM---------------------VVGFPNLGILHVTKKRVLDTLETRMIDACKRGYNPGLLVHPDLN X_tropicalis_ENSXETP00000046127 KIHNYVGQVKIIVQ--LITN-SKDIR-LHAHSLVGKN-C-EDGICSLTVGPK-DT---------------------IVGFANLGILHVTKKKVIEILEARMTDAFKKGHNAALLVHPELN T_nigroviridis_ENSTNIP00000005249 NVNNYQGPARVVVQ--LVTALHQSPQ-LHAHSLVGKQ-C-EKGICTADLQPKLPV---------------------LCSFPNLGILHVTKKNVTKTLEERMVEAFRMGHNYGVCIHPEID G_aculeatus_ENSGACP00000022290 KISNYQGPARVVVQ--LVTALTTHPQ-LHAHSLVGKQ-C-DKGICITDLQPK-DS---------------------TISFPNLGILHVTKKNVAKTLEERMVEAARLGYNCGISIHPDID G_gorilla_ENSGGOP00000008878 KXXXXXXXXXXXXX--XXXX-XXXXX-XXXXXXXXXX-X-XXXXXXXXXXXX-XX---------------------XXXFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLA T_rubripes_ENSTRUP00000010369 KISNYVGHARVEVQ--LVTH-TDPPR-VHAHSLVGRH-CTENGTCMVDVGPN-DL---------------------TASFSNLGILHVTKKSVVEVLNKRLREERRRQKAAHCLLTDVLT G_aculeatus_ENSGACP00000001732 KINNYVGHARVEVQ--LVSH-TDPPS-VHAHSLVGRH-CTENGTCTLDIGPN-DL---------------------AASFSNLGILHVTKKGVVEVLSRRLRDERKRLKGPHCHLTGTHT A_carolinensis_ENSACAP00000014173 KISNYVGLARIEVD--LVTH-TDPPQ-VHAHSLVGKQ-CNEDGNCIVTVGPK-DM---------------------TAQFNNLGVLHVTKKNMMEIIKNKLQKQKMRNRSQT-------- T_guttata_ENSTGUP00000007782 KICNYTGMARIEVD--LVTH-SDPPR-VHAHSLVGKQ-CNEAGNCVTIVGPK-DM---------------------TAQFSNLGVLHVTKKNMMEIMKEKLKQQKMRNRSRL-------- C_familiaris_ENSCAFP00000014918 KICNYEGPAKIEVD--LVTH-SDPPR-AHAHSLVGKQ-CSELGVCAVSVGPK-DM---------------------TAQFNNLGVLHVTKKNMMEIMIQKLQRQRLRSRPQG-------- M_musculus_ENSMUSP00000072859 KICNYEGPAKIEVD--LVTH-SDPPR-AHAHSLVGKQ-CSELGVCAVSVGPK-DM---------------------TAQFNNLGVLHVTKKNMMEIMIQKLQRQRLRSKPQG-------- B_taurus_ENSBTAP00000007904 KICNYEGPAKIEVD--LVTH-SDPPR-AHAHSLVGKQ-CSELGVCAVSVGPK-DM---------------------TAQFNNLGVLHVTKKNMMEIMIQKLQRQRLRSRPQG-------- M_mulatta_ENSMMUP00000003997 KICNYEGPAKIEVD--LVTH-SDPPR-AHAHSLVGKQ-CSELGICAVSVGPK-DM---------------------TAQFNNLGVLHVTKKNMMGTMIQKLQRQRLRSRPQG-------- E_caballus_ENSECAP00000017595 KICNYEGPAKIEVD--LVTH-SDPPR-AHAHSLVGKQ-CSELGVCAVSVGPK-DM---------------------TAQFNNLGVLHVTKKNMMEIMIQKLQRQRLRSRPQG-------- H_sapiens_ENSP00000358983 KICNYEGPAKIEVD--LVTH-SDPPR-AHAHSLVGKQ-CSELGICAVSVGPK-DM---------------------TAQFNNLGVLHVTKKNMMGTMIQKLQRQRLRSRPQG-------- T_nigroviridis_ENSTNIP00000016350 KINNYVGHARVEVQ--LVTH-TDPPR-VHAHSLVGRH-CTENGTCTVDVGPN-DL---------------------TASFSNLGILHVTKKSVVEVLTRRLREERRRQKGAHC------- R_norvegicus_ENSRNOP00000026235 KICNYEGPAKIEVD--LVTH-SDPPR-AHAHSLVGKQ-CSELGVCAVSVGPK-DM---------------------TAQFNNLGVLHVTKKNMMEIMIQKLQRQRLRSKPQG-------- O_latipes_ENSORLP00000003676 KINNYVGQARVEVQ--LVTH-TDPPR-VHAHSLVGRN-CTESGTCVLDVGPN-DL---------------------TASFSNLGILHVTKKGVVDVLTRRLREERRRQTGGHC------- D_rerio_ENSDARP00000057671 KVLNFVGNARVEVQ--LVTH-TDPPR-VHAHSLVGRH-CNESGVCSVDVGPS-DF---------------------TAQFSNLGILHVTKRGVVEVLTKRLKEEKRKVKGPGY------- D_rerio_ENSDARP00000056498 KVLNFVGNARVEVQ--LVTH-TDPPR-VHAHSLVGRH-CNESGVCSVDVGPS-DF---------------------TAQFSNLGILHVTKRGVVEVLTKRLKEEKRKVKGPGY------- P_pygmaeus_ENSPPYP00000003023 KICNYEGPAKIEVD--LVTH-SDPPR-AHAHSLVGKQ-CSELGICAVSVGPK-DM---------------------TAQFNNLGVLHVTKKNMMGTMIQKLQRQLLRSRPQG-------- X_tropicalis_ENSXETP00000000018 TIFNYVGMARIEVD--LVTH-IDPPR-VHAHSLVGKH-SNETGNCVVTVGPE-DM---------------------TAQFNNLGIVHVTKKSQTEILKEKMKRQILRHTGRNL------- C_intestinalis_ENSCINP00000014252 KICNYQGYARIVVQ--LVTN-EENPR-LHPHSLVGKQ-C-QNGICTVQCGPK-DM---------------------TATFPNLGIQHVTKKNVATILEERYIAAEMQLSSINDGFPQEV- P_troglodytes_ENSPTRP00000005089 KICNYEGPAKIEVD--LVTH-SDPPR-AHAHSLVGKQ-CSELGICAVSVGPK-DM---------------------TAQFNNLGVLHVTKKNMMGTMIQKLQRQRLRSRPQG-------- G_gorilla_ENSGGOP00000006827 KICNYEGPAKIEVD--LVTH-SDPPR-AHAHSLVGKQ-CSELGICAVSVGPK-DM---------------------TAQFNNLGVLHVTKKNMMGTMIQKLQRQRLRSRPQG-------- O_cuniculus_ENSOCUP00000004978 KICNYEGPAKIEVD--LVTH-SDPPR-AHAHSLVGKQ-CSDLGICAVSVGPK-DM---------------------TAQFNNLGVLHVTKKNMMEIMIQKLQRQRLLSRPQG-------- A_aegypti_AAEL007624-PA QLHGFQGEAKIRCS--LFQV-DPNRRAAHSHNLVIKS-G-EIDL----NDPH-DIDVNEEC-------------NYVAMFQGMGIIHTAKKNIAEELSKKMKKQRSVEMN---------- M_mulatta_ENSMMUP00000037540 KINGYTGPGTVRIS--LVTK-DPPHR-PHPHELVGKD-C-RDGFYEAELCPD-RC---------------------IHSFQNLGIQCVKKRDLEQAITQRIQT----------------- M_domestica_ENSMODP00000011996 KIHGYLGPGTVRIS--LVTK-EPPHR-PHPHELVGKD-C-RDGFYEAELCPD-HS---------------------IHSFQNLGIQCVKKRDLEQAIAHRMQT----------------- C_familiaris_ENSCAFP00000019655 KINGYTGPGTVRIS--LVTK-DPPHR-PHPHELVGKD-C-RDGFYEAELCPD-RC---------------------IHSFQNLGIQCVKKRDLEQAISQRIQT----------------- P_pygmaeus_ENSPPYP00000003533 KINGYTGPGTVRIS--LVTK-DPPHR-PHPHELVGKD-C-RDGFYEAELCPD-RC---------------------IHSFQNLGIQCVKKRDLEQAINQRIQT----------------- H_sapiens_ENSP00000384273 KINGYTGPGTVRIS--LVTK-DPPHR-PHPHELVGKD-C-RDGFYEAELCPD-RC---------------------IHSFQNLGIQCVKKRDLEQAISQRIQT----------------- R_norvegicus_ENSRNOP00000044552 KINGYTGPGTVRIS--LVTK-DPPHR-PHPHELVGKD-C-RDGFYEAELCPD-RC---------------------IHSFQNLGIQCVKKRDLEQAISQRIQT----------------- E_caballus_ENSECAP00000011798 KINGYTGPGTVRIS--LVTK-DPPHR-PHPHELVGKD-C-RDGFYEAELCPD-RC---------------------IHSFQNLGIQCVKKRDLEQAISQRIQT----------------- B_taurus_ENSBTAP00000018453 KINGYTGPGTVRIS--LVTK-DPPHR-PHPHELVGKD-C-RDGFYEAELCPD-RC---------------------IHSFQNLGIQCVKKRDLEQAISQRIQT----------------- P_troglodytes_ENSPTRP00000006707 KINGYTGPGTVRIS--LVTK-DPPHR-PHPHELVGKD-C-RDGFYEAELCPD-RC---------------------IHSFQNLGIQCVKKRDLEQAISQRIQT----------------- X_tropicalis_ENSXETP00000055326 KINHYQGSARIRIS--LVTK-DSPHK-PHPHELVGKD-C-KDGYYEAELSPD-RS---------------------IHSFQNLGIQCVKKREVEDAIAHRIRT----------------- M_musculus_ENSMUSP00000025867 KINGYTGPGTVRIS--LVTK-DPPHR-PHPHELVGKD-C-RDGYYEADLCPD-RS---------------------IHSFQNLGIQCVKKRDLEQAISQRIQT----------------- C_familiaris_ENSCAFP00000006862 ELRDCGGLREVEVTACLVWK-DWPHR-VHPHSLVGKD-C-TDGVCRVRLRPH-VSP--------------------RHSFNNLGIQCVRKKEIEAAIERKIQL----------------- B_taurus_ENSBTAP00000049624 ELRDCGGLREVEVTACLVWK-DWPHR-VHPHSLVGKD-C-TDGVCRVRLRPH-VSP--------------------RHSFNNLGIQCVRKKEIEAAIERKIQL----------------- D_melanogaster_FBpp0088375 TLCNYDGPAVIRCS--LFQTNLDS---PHSHQLVVRK-D-DRDVC----DPH-DLHVSKERG------------Y-VAQFINMGIIHTAKKYIFEELCKKKQDRLVFQMN---------- A_aegypti_AAEL006930-PA EVRGYTGRVVVVVS--CVTK-DPPYR-PHPHNLVGKDGC-KKGVCTVEINKS-VM---------------------SYTFCSLGIQCVKKKDIKDALRLREEI----------------- A_gambiae_AGAP006747-PA ELRGYGGEAKVRCS--LYQV-DPQRRAPHSHHLVIKS-G-ELDL----IDPH-DLDVGGAAGAAEPSEGVGGDGKYVATFQGMGIIHTAKKFIAEELYKKLRKHRLCELN---------- 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000226574 YLQAEGGGDRQLGDREKELIRQAAL--QQTKEMDLSVVRLMFTAFLPD-STGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQK-DDI-QIRFYEE-EEN P_troglodytes_ENSPTRP00000028033 YLQAEGGGDRQLGDREKELIRQAAL--QQTKEMDLSVVRLMFTAFLPD-STGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQK-DDI-QIRFYEE-EEN M_mulatta_ENSMMUP00000034946 YLQAEGGGDRQLGDREKELIRQAAL--QQTKEMDLSVVRLMFTAFLPD-STGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQK-DDI-QIRFYEE-EEN P_pygmaeus_ENSPPYP00000016712 YLQAEGGGDRQLGDREKELIRQAAL--QQTKEMDLSVVRLMFTAFLPD-STGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQK-DDI-QIRFYEE-EEN C_familiaris_ENSCAFP00000015815 YLQAEGGGDRQLTDREKEIIRQAAL--QQTKEMDLSVVRLMFTAFLPD-STGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQK-DDI-QIRFYEE-EEN B_taurus_ENSBTAP00000027016 YLQAEGGGDRQLTDRDKEIIRQAAL--QQTKDMDLSVVRLMFTAFLPD-STGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQK-DDI-QIRFYEE-EEN E_caballus_ENSECAP00000013133 YLQAEGGGDRQLTDREKEVIHQAAL--QQTKEMDLSVVRLMFTAFLPD-STGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQK-DDI-QIRFYEE-EEN M_musculus_ENSMUSP00000029812 YLQAEGGGDRQLTDREKEIIRQAAV--QQTKEMDLSVVRLMFTAFLPD-STGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQK-DDI-QIRFYEE-EEN R_norvegicus_ENSRNOP00000028944 YLQAEGGGDRQLTDREKEIIRQAAL--QQTKEMDLSVVRLMFTAFLPD-STGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQK-DDI-QIRFYEE-EEN M_domestica_ENSMODP00000025861 YLQPEGGGERQLTDREKEIIRQAAV--QQTKEMDLSVVRLMFTAFLPD-STGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQK-DDI-QIRFYEE-EEN T_guttata_ENSTGUP00000003727 YLQAEGCEDRQLTERERELIRQAAI--QQTKDMDLSVVRLMFTAFLPD-SNGSFTRRLDPVISDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQK-DDI-QIRFYEE-DEN G_gallus_ENSGALP00000020084 YLQAEGCGDRQLTEREREIIRQAAV--QQTKEMDLSVVRLMFTAFLPD-SNGGFTRRLDPVISDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQK-DDI-QIRFYEE-DEN A_carolinensis_ENSACAP00000015967 YIQAESGGERQLTEREREIIHQAAL--HQTKEMDLSVVRLMFTAFLPD-STGSFTRRLQPVLSDPIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQK-DDI-QIRFYEE-DEN X_tropicalis_ENSXETP00000046127 YTYSE---DRQLNVREKEIIRQAAM--QQAKDIDLSVVRLMFTAFLPD-SEGRFTRSLEPVVSVPIFDSKAPNASNLKIVRMDRTAGCVTGGEEVYLLCDKVQK-DDI-QVRFYEE-DEN T_nigroviridis_ENSTNIP00000005249 GQQGEVRVPRELTDHQRSLISSAAA--VQAKDMDLSVVRLMFTVFLPD-SDGGFSRRLEPVVSDPIYDSKAPNASNLKIVRMDRTAGCVSGGEEVYLLCDKVQK-DDI-QVRFYEE-DDS G_aculeatus_ENSGACP00000022290 VLQGEVRVPRELNDDQRRVISSAAS--LQAKEMDLSVVRLMFTAFLPN-SDGGFSRRLEPVVSEPIYDSKAPNASNLKIVRMDRTAGCVSGGEEVYLLCDKVQKVDDI-QVRFYEE-DDS G_gorilla_ENSGGOP00000008878 YLQAEGGGDRQLGXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXX-XXXXXXX-XXX T_rubripes_ENSTRUP00000010369 YLISLGSPRRHPSDLEESSILKEAK--ELGKVMDLNIVRLKFTAYLQD-SNGGFTRALKPVVSNAIYDSKSPNASNLKISRMDKTCGTVLGGDEIFLLCDKVQK-DDI-EIRFYEE-DEG G_aculeatus_ENSGACP00000001732 ----SQASHNTLPHSEENGLLKEAK--ELGKVMDLNIVRLKFTAYLQD-SNGGFTRGLKPVVSNPIYDSKSPNASNLKISRMDKTCGTVLGGDEIFLLCDKVQK-DDI-EIRFYEEDDEG A_carolinensis_ENSACAP00000014173 -----------LTESDHDELEQEAK--ELKKTMDLSIVRLRFSAYLRD-SNGNFTLALKPVVSDPIHDSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQK-DDIGRYDFPED-DEN T_guttata_ENSTGUP00000007782 -----------LTEVELREIELEAK--ELKKVMDLSIVRLRFTAYLRD-SSGNFTLALQPVISDPIHDSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQK-DDI-EVRFYED-DEN C_familiaris_ENSCAFP00000014918 -----------LTEAERRELEQEAK--ELKKVMDLSIVRLRFSAFLRA-SDGSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQK-DDI-EVRFYED-DEN M_musculus_ENSMUSP00000072859 -----------LTEAERRELEQEAK--ELKKVMDLSIVRLRFSAFLRA-SDGSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQK-DDI-EVRFYED-DEN B_taurus_ENSBTAP00000007904 -----------LTEAERRELEQEAK--ELKKVMDLSIVRLRFSAFLRA-SDGSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQK-DDI-EVRFYED-DEN M_mulatta_ENSMMUP00000003997 -----------LTEAEQRELEQEAK--ELKKVMDLSIVRLRFSAFLRA-SDGSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQK-DDI-EVRFYED-DEN E_caballus_ENSECAP00000017595 -----------LTETERRELEQEAK--ELKKVMDLSIVRLRFSAFLRA-SDGSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQK-DDI-EVRFYED-DEN H_sapiens_ENSP00000358983 -----------LTEAEQRELEQEAK--ELKKVMDLSIVRLRFSAFLRA-SDGSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQK-DDI-EVRFYED-DEN T_nigroviridis_ENSTNIP00000016350 ----------HLTDSEENSILKEAK--ELGKVMDLNIVRLKFTAFLQD-SNGGFTRALKPVVSNAIYDSKSPNASNLKISRMDKTCGTVLGGDEIFLLCDKVQK-DDI-EIRFYEE-DEG R_norvegicus_ENSRNOP00000026235 -----------LTEAERRELEQEAK--ELKKVMDLSIVRLRFSAFLRA-SDGSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQK-DDI-EVRFYED-DEN O_latipes_ENSORLP00000003676 ----------HLTDAEEASIQKEVK--ELSKSMDLNIVRLKFTAYLQD-SNGGFTRALKPVVSNPIYDSKSPNASNLKISRMDKTCGSVLGGDEIFLLCDKVQK-DDI-EIRFYEEDDEG D_rerio_ENSDARP00000057671 ----------KFSDAEENALMQEAK--ELGKNMDLNIVRLKFTAYLQD-SNGSYTRALKPVVSNPIYDSKSPNASNLKISRMDKTSGSVLGGEEVFLLCDKVQK-DDI-DIRFYEEEDE- D_rerio_ENSDARP00000056498 ----------KFSDAEENALMQEAK--ELGKNMDLNIVRLKFTAYLQD-SNGSYTRALKPVVSNPIYDSKSPNASNLKISRMDKTSGSVLGGEEVFLLCDKVQK-DDI-DIRFYEEEDE- P_pygmaeus_ENSPPYP00000003023 -----------LTEAEQRELEQEAK--ELKKVMDLSIVRLRFSAFLRA-SDGSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQK-DDI-EVRFYED-DEN X_tropicalis_ENSXETP00000000018 -----------LTEAEERRIEQEVK--ELKKVTDLSIVRLRFTAYLPD-SNGAYTLGLPPVISDPIHDSKSPGASNLRISRMDKTAGSVKGGDEVYLLCDKVQK-DDI-EVRFYED-DEN C_intestinalis_ENSCINP00000014252 --------QRNIKDEDRKRIAAKAQ--SEAKSIDLSVVRLMFIAYLPD-SNGAFTIMLKPVISDAIFDSKAPNAATLKICRMDCNAGSASGGDEVYLLCDKVQK-DDI-QVVFSEE-DMQ P_troglodytes_ENSPTRP00000005089 -----------LTEAEQRELEQEAK--ELKKVMDLSIVRLRFSAFLRA-SDGSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQK-DDI-EVRFYED-DEN G_gorilla_ENSGGOP00000006827 -----------L-KAEQRELEQEAK--ELKKVMDLSIVRLRFSAFLRA-SDGSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQK-DDI-EVRFYED-DEN O_cuniculus_ENSOCUP00000004978 -----------LTEAERRELEQEAK--ELKKVMDLSIVRLRFSAFLRA-SDGSFSLPLKPVISQPIHDSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXX-XXXXXXX-XXX A_aegypti_AAEL007624-PA ---------RELTLREEYQLQKEAA--EMAKTMNLNQVCLCFQAFQVDASTGRWAQLCEPVYSNPINNMKSALTGELKICRLSATVGNVDGGEEVFMFVEKVCK-NNI-KIRFYEL-DEY M_mulatta_ENSMMUP00000037540 ---------------NNNPFQVPIE--EQRGDYDLNAVRLCFQVTVRD-PSGRPL-RLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQK-EDI-EVYFTGP-G-- M_domestica_ENSMODP00000011996 ---------------NNNPFNVPLE--EQRGDYDLNAVRLCFQVTIQD-SAGRPL-VLPPVLSHPIYDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQK-EDI-EVCFSGP-G-- C_familiaris_ENSCAFP00000019655 ---------------NNNPFQVPIE--EQRGDYDLNAVRLCFQVTVRD-PAGRPL-RLSPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQK-EDI-EVYFTGP-G-- P_pygmaeus_ENSPPYP00000003533 ---------------NNNPFQVPIE--EQRGDYDLNAVRLCFQVTVRD-PSGRPL-RLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQK-EDI-EVYFTGP-G-- H_sapiens_ENSP00000384273 ---------------NNNPFQVPIE--EQRGDYDLNAVRLCFQVTVRD-PSGRPL-RLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQK-EDI-EVYFTGP-G-- R_norvegicus_ENSRNOP00000044552 ---------------NNNPFQVPIE--EQRGDYDLNAVRLCFQVTVRD-PSGRPL-RLTPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQK-EDI-EVYFTGP-G-- E_caballus_ENSECAP00000011798 ---------------NNNPFQVPIE--EQRGDYDLNAVRLCFQVTVRD-PAGRPL-RLSPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQK-EDI-EVYFTGP-G-- B_taurus_ENSBTAP00000018453 ---------------NNNPFQVPIE--EQRGDYDLNAVRLCFQVTVRD-PAGRPL-RLAPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQK-EDI-EVYFTGP-G-- P_troglodytes_ENSPTRP00000006707 ---------------NNNPFQVPIE--EQRGDYDLNAVRLCFQVTVRE-PSGRPL-RLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQK-EDI-EVYFTGP-G-- X_tropicalis_ENSXETP00000055326 ---------------NNNPFNVPPE--ELKSDYDLNTVCLCFQVFIPDRAAGQVV-PLPFVVSQPIYDNRAPNTAELKICRVNRNSGSCMGGDEIFLLCDKVQK-EDI-EVLFVLG-N-- M_musculus_ENSMUSP00000025867 ---------------NNNPFHVPIE--EQRGDYDLNAVRLCFQVTVRD-PAGRPL-LLTPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQK-EDI-EVYFTGP-G-- C_familiaris_ENSCAFP00000006862 ---------------GIDPYNAGSL--KNHQEVDMNVVRICFQASYRD-QQGQMR-RMDPVLSEPVYDKKSTNTSELRICRINKESGPCTGGEELYLLCDKVQK-EDI-SVVFSRA-S-- B_taurus_ENSBTAP00000049624 ---------------GIDPYNAGSL--KNHQEVDMNVVRICFQASYRD-QQGQMR-RMDPVLSEPVYDKKSTNTSELRICRINKESGPCTGGEELYLLCDKVQK-EDI-SVVFSRA-S-- D_melanogaster_FBpp0088375 --------RRELSHKQLQELHQETE--REAKDMNLNQVRLCFEAFKIE-DNGAWVPLAPPVYSNAINNRKSAQTGELRIVRLSKPTGGVMGNDELILLVEKVSK-KNI-KVRFFEE-DED A_aegypti_AAEL006930-PA ---------------RVDPFKTGYGHGRQPASIDLNAVRLCFQAFLEGPQQGHFTNPLVPVVSDIIYDKKA--MSELVICKLSHVAAPMSGGKEVILLCEKVAK-EDI-AVRFYEE--HQ A_gambiae_AGAP006747-PA ---------REPTEREEQQMQKEAA--VMARTMNLNQVCLCFRAYRVEPGTGRWVPICEPVYSNPINNMKSALTGELKICRLSTTVSGVDGGEEVFMFVEKVCK-NNI-KIRFYEL-DEY 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000226574 G-GVWEGFGDFSPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEP-KPFLYYPEIK-------DKEEVQRKRQKLMP-NFSDSFGG-GSG--AG---------------- P_troglodytes_ENSPTRP00000028033 G-GVWEGFGDFSPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEP-KPFLYYPEIK-------DKEEVQRKRQKLMP-NFSDSFGG-GSG--AG---------------- M_mulatta_ENSMMUP00000034946 G-GVWEGFGDFSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEP-KPFLYYPEIK-------DKEEVQRKRQKLMP-NFSDSFGG-GSG--AG---------------- P_pygmaeus_ENSPPYP00000016712 G-GVWEGFGDFSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEP-KPFLYYPEIK-------DKEEVQRKRQKLMP-NFSDSFGG-GSG--AG---------------- C_familiaris_ENSCAFP00000015815 G-GIWEGFGDFSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEP-KPFLYYPEIK-------DKEEVQRKRQKLMP-NFSDSFGG-GSG--AG---------------- B_taurus_ENSBTAP00000027016 G-GIWEGFGDFSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEP-KPFLYYPEIK-------DKEEVQRKRQKLMP-NFSDSFGG-GSG--AG---------------- E_caballus_ENSECAP00000013133 G-GIWEGFGDFSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEP-KPFLYYPEIK-------DKEEVQRKRQKLMP-NFSDSFGG-GSG--AG---------------- M_musculus_ENSMUSP00000029812 G-GVWEGFGDFSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEP-KPFLYYPEIK-------DKEEVQRKRQKLMP-NFSDSFGG-GSG--AG---------------- R_norvegicus_ENSRNOP00000028944 G-GVWEGFGDFSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEP-KPFLYYPEIK-------DKEEVQRKRQKLMP-NFSDSFGG-GSG--AG---------------- M_domestica_ENSMODP00000025861 G-GFWEGFGDFSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEP-KPFLYYPEIK-------DKEEVQRKRQKLMP-NFSDR--------------------------- T_guttata_ENSTGUP00000003727 G-GMWEGFGDFSPTDVHRQFAIVFKTPKYRDVNITKPASVFVQLRRKSDLETSEP-KPFLYYPEIK-------DKEEVQRKRQKLMP-NFSDGYGG-GS----G---------------- G_gallus_ENSGALP00000020084 G-GMWEGFGDFSPTDVHRQFAIVFKTPKYRDVNITKPASVFVQLRRKSDLETSEP-KPFLYYPEIK-------DKEEVQRKRQKLMP-NFSDGYGG-GS----G---------------- A_carolinensis_ENSACAP00000015967 G-GVWEGFGDFSPTDVHRQFAIVFKTPKYRDVNITKPASVFVQLRRKSDLETSEP-KPFLYYPEIK-------DKEEVQRKRQKLMP-NFSDSY-G-GSG--AG---------------- X_tropicalis_ENSXETP00000046127 G-GFWEGFGDFSPTDVHRQFAIVFKTPKYKDVNITKAASVFVQLRRKSDYETSEP-KPFLYYPEIK-------DKEEVQRKRQKLMP-NFSDGFGGSGAG--SG---------------- T_nigroviridis_ENSTNIP00000005249 G-LTWEALGDFSPTDVHRQFAIVFKTPKYRDQNLQKPTSVFVQLKRKSDNETSEP-KPFTYHPQVI-----GSDKEEVQRKRQKTLP-NFHDFLHR-GGG--PG---------------- G_aculeatus_ENSGACP00000022290 G-LTWEAMGDFSPTDVHRQFAIVFKTPKYRDQNLQKPTSVLVQLKRKSDNETSEP-KPFTYHPQII-------DKEEVQRKRQKTLP-NFQDFSGH-GGG--GGLYR------------- G_gorilla_ENSGGOP00000008878 X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXX-------XKEEVQRKRQKLMP-NFSDSFGG-GSG--AG---------------- T_rubripes_ENSTRUP00000010369 G---WEAFGDFSPTDVHKQYAIVFKTPPYHSAEIERPVTVFLQLKRKKAGDSSDP-KQFTYIPHVQ-------DKEEVLRKKQKPLP-HYESWRGG-AGGGAG----------------- G_aculeatus_ENSGACP00000001732 G---WEAFGDFSPTDVHKQVLSSFRTPPYHTAEIERPVTVFLQLKRKKAGDSSDP-KQFTYTPQVQ-------DKEEVLRKKQKPLP-HYEPSTAF------------------------ A_carolinensis_ENSACAP00000014173 G---WQAL-DSPPTDVHKQYAIVFRTPPYHKTQIDRPVTVFLQLKRKRGGDVSDS-KQFTYYPIVE-------DKEEVERKRKKFLP-QFPQHFGG-GAPM-GG---------------- T_guttata_ENSTGUP00000007782 G---WQAFGDFSPTDVHKQYAIVFRTPPYHKPKIDRPVTVFLQLKRKRGGDVSDS-KQFTYYPVVE-------DKEEVERKRKKVLP-QFPQHFGG-GSHM-GG---------------- C_familiaris_ENSCAFP00000014918 G---WQAFGDFSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDS-KQFTYYPRAA-------DKEEVQRKRRKALP-TFSQHFGG-GSHKIRE---------------- M_musculus_ENSMUSP00000072859 G---WQAFGDFSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDS-KQFTYYPLVE-------DKEEVQRKRRKALP-TFSQPFGG-GSHMGGG---------------- B_taurus_ENSBTAP00000007904 G---WQAFGDFSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDS-KQFTYYPLVE-------DKEEVQRKRRKALP-TFSQPFGG-GSHMGGG---------------- M_mulatta_ENSMMUP00000003997 G---WQAFGDFSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDS-KQFTYYPLVE-------DKEEVQRKRRKALP-TFSQPFGG-GSHMGGG---------------- E_caballus_ENSECAP00000017595 G---WQAFGDFSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDS-KQFTYYPLVE-------DKEEVQRKRRKALP-TFSQHFGG-GSHMGGG---------------- H_sapiens_ENSP00000358983 G---WQAFGDFSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDS-KQFTYYPLVE-------DKEEVQRKRRKALP-TFSQPFGG-GSHMGGG---------------- T_nigroviridis_ENSTNIP00000016350 G---WEAFGDFSPTDVHKQYAIVFKTPPYHSAEIERPVTVFLQLKRKKAGDSSDP-KQFTYIPHVQ-------DKEEVLRKKQKPLP-HYEPWFGG------------------------ R_norvegicus_ENSRNOP00000026235 G---WQAFGDFSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDS-KQFTYYPLVE-------DKEEVQRKRRKALP-TFSQPFGG-GSHMGGG---------------- O_latipes_ENSORLP00000003676 G---WEAFGDFSPTDVHKQYAIVFKTPPYHSTEIQRSVTVFLQLRRKKAGDSSDP-KQFTYIPQVQ-------DKEEVLRKKQKPLP-HYESWRGG-GR--------------------- D_rerio_ENSDARP00000057671 ----WEALGDFSPTDVHKQYAIVFKTPPYRCTNIDRPVTVFLQLKRKKGGDCSEP-KQFTYVPHNQ-------DKEEVQRKRMKALPDHYGGWRGG-PQGGAGG---------------- D_rerio_ENSDARP00000056498 ----WEALGDFSPTDVHKQYAIVFKTPPYRCTNIDRPVTVFLQLKRKKGGDCSEP-KQFTYVPHNQ-------DKEEVQRKRMKALPDHYGGWRGG-PQGGAGG---------------- P_pygmaeus_ENSPPYP00000003023 G---WQAFGDFSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDS-KQFTYYPLVE-------DKEEVQRKRRKALP-TFSQPFGG-GSHMGGG---------------- X_tropicalis_ENSXETP00000000018 G---WQSFGDFAPTDVHKQYAIVFRTPPYHTQKIDRPVTVFLQLKRKKGGDVSDS-KQFTYYPLEQ-------DKEEVDRKRRKDLP-TFNNHFFGGGSPM-GG---------------- C_intestinalis_ENSCINP00000014252 GNNLWEAYGSFSPTDVHRQFAIVFRTPAYKDTEIKMPVNVQVQLRRKSDNEVSES-RPFTYLPNKS-------DLELIDRKRRKVMP-DFLDHTGN-GST--GGYSFNPQAAILPSSYNF P_troglodytes_ENSPTRP00000005089 G---WQAFGDFSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDS-KQFTYYPLVE-------DKEEVQRKRRKALP-TFSQPFGG-GSHMGGG---------------- G_gorilla_ENSGGOP00000006827 G---WQAFGDFSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDS-KQFTYYPLVE-------DKEEVQRKRRKALP-TFSQPFGG-GSHMGGG---------------- O_cuniculus_ENSOCUP00000004978 X---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXX-------XXXXXXXXXXXXXX-XXXXXXXX-XXXXXXX---------------- A_aegypti_AAEL007624-PA DQEIWQDWGSFSEADVHHQYAIAFKTPAYHNKDITEPVEVLMQLYRPRDKCQSEP-VPFKFKPRFN-----------ISRKRPRVSSGLLSNEIPTVVPNEP------------------ M_mulatta_ENSMMUP00000037540 ----WEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEP-MEFQYLPDTD-------DRHRIEEKRKRTYE-TFKSIMKK-SPF-------------------- M_domestica_ENSMODP00000011996 ----WEARGSFSQADVHRQVAIVFRTPPYAEAALQAPVRVHMQLRRPSDRELSEP-MEFQYLPDTD-------DRHRIEEKRKRTLG-TFKNIMKT-SPF-------------------- C_familiaris_ENSCAFP00000019655 ----WEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVTMQLRRPSDRELSEP-MEFQYLPDTD-------DRHRIEEKRKRTYE-TFKSIMKK-SPF-------------------- P_pygmaeus_ENSPPYP00000003533 ----WEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEP-MEFQYLPDTD-------DRHRIEEKRKRTYE-TFKSIMKK-SPF-------------------- H_sapiens_ENSP00000384273 ----WEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEP-MEFQYLPDTD-------DRHRIEEKRKRTYE-TFKSIMKK-SPF-------------------- R_norvegicus_ENSRNOP00000044552 ----WEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEP-MEFQYLPDTD-------DRHRIEEKRKRTYE-TFKSIMKK-SPF-------------------- E_caballus_ENSECAP00000011798 ----WEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEP-MEFQYLPDTD-------DRHRIEEKRKRTYE-TFKSIMKK-SPF-------------------- B_taurus_ENSBTAP00000018453 ----WEARGSFSQADVHRQVAIVFRTPPYADPGLQAPVRVSMQLRRPSDRELSEP-MEFQYLPDTD-------DRHRIEEKRKRTYE-TFKSIMKK-SPF-------------------- P_troglodytes_ENSPTRP00000006707 ----WEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEP-MEFQYLPDTD-------DRHRIEEKRKRTYE-TFKSIMKK-SPF-------------------- X_tropicalis_ENSXETP00000055326 ----WEARGIFSQADVHRQVAIVFRTPAFQDTKIRQSVKVQMQLRRPSDKEVSEP-MEFQYLPDEV-------DPHHIDEKRKRTLD-SFKHYVK--NPF-------------------- M_musculus_ENSMUSP00000025867 ----WEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEP-MEFQYLPDTD-------DRHRIEEKRKRTYE-TFKSIMKK-SPF-------------------- C_familiaris_ENSCAFP00000006862 ----WEGRADFSQADVHRQIAIVFKTPPYEDLEIVEPVTVNVFLQRLTDGVCSEP-LPFTYLPRDH-------DSYGVDKKRKRGMP-DVLGELNS-SDP-------------------- B_taurus_ENSBTAP00000049624 ----WEGRADFSQADVHRQIAIVFKTPPYEDLEIVEPVTVNVFLQRLTDGVCSEP-LPFTYLPRDH-------DSYGVDKKRKRGLP-DVLGELNS-SDP-------------------- D_melanogaster_FBpp0088375 GETVWEAYAKFRESDVHHQYAIVCQTPPYKDKDVDREVNVYIELIRPSDDERSFPALPFRYKPRSV----------IVSRKRRRTGSSANSSSSGTESSN-------------------- A_aegypti_AAEL006930-PA GKIVWEDQGEFQHSNVHKQVAISFRTPRYRSLDVDFPVMVHIQLQRPSDGATSEP-VPFELIPVDG-------DNFCKKRKRSQFNSFELTEQNTR------------------------ A_gambiae_AGAP006747-PA DQEVWQEMAIFSEADVHHQYAIAFKTPPYRHKDITEPVEVLMQLFRPRDRCQSEP-VLFKYKPRPGMMVVPGAGASGASRKRLRISSGNVSSEIPTVIQNDPNGPVGPAGVGGGGGGGGG 610 620 630 640 650 660 670 680 690 700 710 720 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000226574 AGGGGMFGS-GGGGGG-TGSTGP------------------------------------------GYSF-PHYGF------P-TYGGITFHPGTTKSN---------------------- P_troglodytes_ENSPTRP00000028033 AGGGGMFGS-GGGGGG-TGSTGP------------------------------------------GYSF-PHYGF------P-TYGGITFHPGTTKSN---------------------- M_mulatta_ENSMMUP00000034946 AGGGGMFGS-GGGGGG-TGSTGP------------------------------------------GYSF-PHYGF------P-TYGGITFHPGTTKSN---------------------- P_pygmaeus_ENSPPYP00000016712 AGGGGMFGS-GGGGGG-TGSTGP------------------------------------------GYSF-PHYGF------P-TYGGITFHPGTTKSN---------------------- C_familiaris_ENSCAFP00000015815 AGGGGMFGS-GGGGGG-AGSTGP------------------------------------------GYGF-PHYGF------P-TYGGITFHPGTTKSN---------------------- B_taurus_ENSBTAP00000027016 AGGGGMFGS-GGGGGG-AGSTGP------------------------------------------GYGF-PHYGF------P-TYGGITFHTGTTKSN---------------------- E_caballus_ENSECAP00000013133 AGGGGMFGG-GGGGGG-AGSTGP------------------------------------------GYGF-PHYGF------P-TYGGITFHPGAAKSN---------------------- M_musculus_ENSMUSP00000029812 AGGGGMFGS-GGGGGS-TGSPGP------------------------------------------GYGY-SNYGF------P-PYGGITFHPGVTKSN---------------------- R_norvegicus_ENSRNOP00000028944 AGGGGMFGS-GGGGGGSTGSPGP------------------------------------------GYGF-PHYGF------P-AYGGIAFHPGATKSN---------------------- M_domestica_ENSMODP00000025861 ------------------------------------------------------------------YGF-APYGF--------SYAGIPFHPGTTKSN---------------------- T_guttata_ENSTGUP00000003727 TGGGGMYGG-AG------GSAGS------------------------------------------GFSF-PSYGY------S-AFGGMHF-PGTTKSN---------------------- G_gallus_ENSGALP00000020084 AGGGGMFGG-GG------GGAGS------------------------------------------GFSY-PSYGY------S-AFGGMHFHPGTTKSN---------------------- A_carolinensis_ENSACAP00000015967 AGGGGMYGG-GGGGGG--GGVGG------------------------------------------GYGY-SPYGF------S-GYGAMHFHSSTNKTG---------------------- X_tropicalis_ENSXETP00000046127 GGGGGLYGG-GGGAGG--SGAGG------------------------------------------SYGF-SSFSY------N-NYGGLNFHGGPMNSS---------------------- T_nigroviridis_ENSTNIP00000005249 AGGPGSAGG-GGGSGC-PGSDAH------------------------------------------HLSF-SPPGFFQGFTTY-KNTVRRTSGRQRGKPQVPFLVRKHPDQLITFNLMV-- G_aculeatus_ENSGACP00000022290 GGGGGGRGP-AAGGGP--GSAGG-------------------------------------------------GGYFHGFTTY-NYGGAAAGGGGVGGG---------------------- G_gorilla_ENSGGOP00000008878 AGGGGMFGS-GGGGGG-TGSTGP------------------------------------------GYSF-PHYGF------P-TYGGITFHPGTTKSN---------------------- T_rubripes_ENSTRUP00000010369 FGGGG-----GGGGGG--GGGGG------------------------------------------GFGG-GGYQF------N-QQMN--GGGGVFFPGFTGFNG----G----------- G_aculeatus_ENSGACP00000001732 ---------PHLLHRK--FTVDL------------------------------------------CFPS-AGFQF------N-QQMN---GGVFFTEGFAGF------G----------- A_carolinensis_ENSACAP00000014173 AGGGA-----GGFGSG--GGAGK------------------------------------------KLSFSAYPSF------N-IYLSGTHPVGSYQGG---------------------- T_guttata_ENSTGUP00000007782 AGGGA-----GGFGSG--GGGNL------------------------------------------SFPYSSGLTY------NSIYSPGPHPVGSYQ------------------------ C_familiaris_ENSCAFP00000014918 SPGWCLL---PTARPV--SAGGS------------------------------------------LGFF-PSLAY------S-PYPTGSAPLGCYPGGG--------------------- M_musculus_ENSMUSP00000072859 SGGSA-----GGYGGA--GGGGS------------------------------------------LGFFSSSLAY------N-PYQSGAAPMGCYPGGG--------------------- B_taurus_ENSBTAP00000007904 SGGSA-----GGYGGA-GGGGGS------------------------------------------LGFFPSSLAY------S-PYQSGAAPMGCYPGGG--------------------- M_mulatta_ENSMMUP00000003997 SGGAA-----GGYGGA--GGGGS------------------------------------------LGFFPSSLAY------S-PYQSGAGPMGCYPGGG--------------------- E_caballus_ENSECAP00000017595 SGGSA-----GGYGGA-GGGGGS------------------------------------------LGFF-SSLTY------N-P-QSGAAPMGCYPGGG--------------------- H_sapiens_ENSP00000358983 SGGAA-----GGYGGA--GGGGS------------------------------------------LGFFPSSLAY------S-PYQSGAGPMGCYPGGG--------------------- T_nigroviridis_ENSTNIP00000016350 --------------GG--GAVTI------------------------------------------VWCL-SGYQF------N-SADD--EASPVLTEG---------------------- R_norvegicus_ENSRNOP00000026235 SGGSA-----GGYGGA--GGGGS------------------------------------------LGFF-SSFAY------S-PYQSGAAPMGCFPGGG--------------------- O_latipes_ENSORLP00000003676 ----------GGGAGG--FGGGA------------------------------------------SGGA-GGFQF------H-QQMNGGGGGTFYSEGFTGFT----------------- D_rerio_ENSDARP00000057671 FGGPG-----SGTGGG--GGMG------------------------------------------------GGFPF------N-PMDN----SSFFVGGCGGF------G----------- D_rerio_ENSDARP00000056498 FGGPG-----SGTGGG--GGMG------------------------------------------------GGFPF------N-PMDN----SSFFVGGCGGF------G----------- P_pygmaeus_ENSPPYP00000003023 SGGAA-----GGYGGA--GGGGS------------------------------------------LGFFPSSLAY------S-PYQSGAGPMGCYPGGG--------------------- X_tropicalis_ENSXETP00000000018 AGGGS-----SFGQGG--GGSNI------------------------------------------NYPY-PGMQT------A-FYMSSPAGGGYHSSGHMMKHCSAA------------- C_intestinalis_ENSCINP00000014252 SGNTG-----SGNTAG--NGAGKVKEARRPPQKQQNPQKGPVDPSVLMKLKRIKTEPVQKSSPPTTYSNFPPIAY------MSPAKSEPSPPAPMSIGGSPAAQVPQEEEYLPGTRIPLP P_troglodytes_ENSPTRP00000005089 SGGAA-----GGYGGA--GGGGS------------------------------------------LGFFPSSLAY------S-PYQSGAGPMGCYPGGG--------------------- G_gorilla_ENSGGOP00000006827 SGGAA-----GGYGGA--GGGGS------------------------------------------LGFFPSSLAY------S-PYQSGAGPMGCYPGGG--------------------- O_cuniculus_ENSOCUP00000004978 XXXXX-----XXXXXX--XXXXX------------------------------------------XXXFPSSLAY------S-PYQSGAAPMGCYPGGG--------------------- A_aegypti_AAEL007624-PA ----------GSSRLP---------------------------------------------------SFHHPFSM---------MPPMQAPIAE-------------------------- M_mulatta_ENSMMUP00000037540 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000011996 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000019655 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000003533 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000384273 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000044552 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000011798 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000018453 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000006707 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000055326 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000025867 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000006862 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000049624 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0088375 ----------NSLDLP-------------------------------------------------------------------------------------------------------- A_aegypti_AAEL006930-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP006747-PA GGGGGVIGSGSTTRLP---------------------------------------------------PLHQPFPMLANHAGGGAIPEGQEPTST-------------------------- 730 740 750 760 770 780 790 800 810 820 830 840 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000226574 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000028033 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000034946 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000016712 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000015815 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000027016 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013133 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000029812 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000028944 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000025861 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000003727 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000020084 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000015967 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000046127 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005249 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022290 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008878 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000010369 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000001732 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000014173 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000007782 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014918 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000072859 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000007904 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000003997 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017595 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000358983 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000016350 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000026235 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003676 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000057671 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000056498 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000003023 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000000018 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000014252 KNARPHTGLPQMSFQNPIVLSQQQQMQQQQIQQQQQQHLQQIQQQQAYSNYSPMYSTTYGLDNTQHMVYSTPSPDYGQQIIQQLSPQEVQEYEETVMNELSTVDAGDLVDIMNVDLNHNP P_troglodytes_ENSPTRP00000005089 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006827 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000004978 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007624-PA ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000037540 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000011996 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000019655 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000003533 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000384273 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000044552 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000011798 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000018453 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000006707 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000055326 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000025867 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000006862 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000049624 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0088375 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL006930-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP006747-PA ------------------------------------------------------------------------------------------------------------------------ 850 860 870 880 890 900 910 920 930 940 950 960 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000226574 -----------------------------------------------------------------------------AGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQD-Q P_troglodytes_ENSPTRP00000028033 -----------------------------------------------------------------------------AGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQD-Q M_mulatta_ENSMMUP00000034946 -----------------------------------------------------------------------------AGMKHGTMDTESKKDSEGCDRSDDRNTVNLFGKVIETTEHN-Q P_pygmaeus_ENSPPYP00000016712 -----------------------------------------------------------------------------AGMKHGTMDTESEKDPEGCDKSDDKNTVNLFGKVIETTEQD-Q C_familiaris_ENSCAFP00000015815 -----------------------------------------------------------------------------AGMKHGTIDTPSKNDSEGCGKNVDREAVNLSGKVTEPTEQD-K B_taurus_ENSBTAP00000027016 -----------------------------------------------------------------------------AGMKHGTIDTPSKNDPESCGKSDDREVVNLSEQVTETTEQD-G E_caballus_ENSECAP00000013133 -----------------------------------------------------------------------------AGMKHGTIDTSCKNDPEGCDASDDREAVNLSGKGTETTARK-D M_musculus_ENSMUSP00000029812 -----------------------------------------------------------------------------AGVTHGTINTKFKNGPKDCAKSDDEESLTLPEKETEGEGPSLP R_norvegicus_ENSRNOP00000028944 -----------------------------------------------------------------------------TGITHGTINTKFKNEPRDCAKSDDREILNPPEKETQGEGPSLF M_domestica_ENSMODP00000025861 -----------------------------------------------------------------------------AGMKHGTLDSSSVQGHAGCDESDDRSSAELSGKILKTTEQD-D T_guttata_ENSTGUP00000003727 -----------------------------------------------------------------------------AGMKHGLSNCTAEQDRKSCDKQNDQWDMKCDVKAEAVERTE-C G_gallus_ENSGALP00000020084 -----------------------------------------------------------------------------AGMKHELSNSTVKKDEESSDKQSDKWDTKHDVKVETVEKNE-C A_carolinensis_ENSACAP00000015967 -----------------------------------------------------------------------------AGMKHGTFYLPLLHLKEATGIYCNNEMVSIRLQPSVPATQK-D X_tropicalis_ENSXETP00000046127 -----------------------------------------------------------------------------PCMKHE-SQPQCEANQKHVETMNIQDAPNEVVCLCFDTVQE-- T_nigroviridis_ENSTNIP00000005249 -----------------------------------------------------------------------------GGVQASQGGAVSSD----EDGDPEDGSGS----APRRKARP-- G_aculeatus_ENSGACP00000022290 -----------------------------------------------------------------------------GGFSTGYSAEASEDNQAADDKHPDDDSGSDVGVGPAVGEGP-- G_gorilla_ENSGGOP00000008878 -----------------------------------------------------------------------------AGMKHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-X T_rubripes_ENSTRUP00000010369 -----------------------------------------------------------------------------GGAQMSCSAPPSQRVGQPRGQSAAAPLQHQLFQIGET------ G_aculeatus_ENSGACP00000001732 -----------------------------------------------------------------------------GGAQMSGSHP--QTGV--TQQHSGSPAQQQLLQLGER------ A_carolinensis_ENSACAP00000014173 -----------------------------------------------------------------------------RGIQMPKAVP--VEDGDHQLSEDG----KQAFTEEKDCLE--- T_guttata_ENSTGUP00000007782 -----------------------------------------------------------------------------GGVQMKGPEA--------EGPESD----RQAPAEESTYCKE-- C_familiaris_ENSCAFP00000014918 -----------------------------------------------------------------------------GGAQMAAGAP--GVDAGEEAAEPS--ASPLTPQREPQAPE--- M_musculus_ENSMUSP00000072859 -----------------------------------------------------------------------------GGAQMAGSRR--DTDAGEGAEEPR--TPPEAPQGEPQALD--- B_taurus_ENSBTAP00000007904 -----------------------------------------------------------------------------GGAQMAAETP--SVDAGEEAAEPS--APPGTPQREQQTPE--- M_mulatta_ENSMMUP00000003997 -----------------------------------------------------------------------------GGAQMAASVP--GRDSGEEAAEPS--APSRAPQCEPQAPE--- E_caballus_ENSECAP00000017595 -----------------------------------------------------------------------------GGAQMAAGAP--SVDAGEEAAEPS--ASPVIPQHEPQAPE--- H_sapiens_ENSP00000358983 -----------------------------------------------------------------------------GGAQMAATVP--SRDSGEEAAEPS--APSRTPQCEPQAPE--- T_nigroviridis_ENSTNIP00000016350 -----------------------------------------------------------------------------AGTQMSGSAPRPQRGGH-TRGPNVAAPLQRLHRIA-------- R_norvegicus_ENSRNOP00000026235 -----------------------------------------------------------------------------GGAQMAGSGR--DAEAGEAEEQPR--APSEAPQSEQQALD--- O_latipes_ENSORLP00000003676 -----------------------------------------------------------------------------GAAQMSGSAP------QQSDRPAGSPLQQQLLQIA-------- D_rerio_ENSDARP00000057671 -----------------------------------------------------------------------------GGAQMSDSPP--QTDGANTQSQSNSQIRQQLIQIA-------- D_rerio_ENSDARP00000056498 -----------------------------------------------------------------------------GGAQMSDSPP--QTDGANTQSQSNSQIRQQLIQIA-------- P_pygmaeus_ENSPPYP00000003023 -----------------------------------------------------------------------------GGAQMAATVP--SRDSGEEAAEPS--APSRTPQCEPQAPE--- X_tropicalis_ENSXETP00000000018 -----------------------------------------------------------------------------NSSEKNQAPSINIKKEGEEASACSQQARSTSAQKETQ-CQM-- C_intestinalis_ENSCINP00000014252 MPQTTNSNIINQAYDQANILTQTNNTYGGGDGSFRGSVVDPIIPQPLSNAPLPILSQQFSQQLLELTEYDLADIESDAGAERKPKPGNNNDDEQEEDYASAYCEEQDTTDSTAHEAEPKS P_troglodytes_ENSPTRP00000005089 -----------------------------------------------------------------------------GGAQMAATVP--SRDSGEEAAEPS--APSRTPQCEPQAPE--- G_gorilla_ENSGGOP00000006827 -----------------------------------------------------------------------------GGAQMAATVP--SRDSGEEAAEPS--APSRTPQCEPQAPE--- O_cuniculus_ENSOCUP00000004978 -----------------------------------------------------------------------------GGAQMAASAP--GVDAGEQATEAS--KPR-----QAQAPE--- A_aegypti_AAEL007624-PA -----------------------------------------------------------------------------ASGSSSSH------------TISKEYNKSGIIQEILDSHIPTT M_mulatta_ENSMMUP00000037540 -----------------------------------------------------------------------------SGPT-DPRPP--------------------------------- M_domestica_ENSMODP00000011996 -----------------------------------------------------------------------------SGGNPDTWTS--------------------------------- C_familiaris_ENSCAFP00000019655 -----------------------------------------------------------------------------NGPT-DPRPP--------------------------------- P_pygmaeus_ENSPPYP00000003533 -----------------------------------------------------------------------------SGPT-DPRPP--------------------------------- H_sapiens_ENSP00000384273 -----------------------------------------------------------------------------SGPT-DPRPP--------------------------------- R_norvegicus_ENSRNOP00000044552 -----------------------------------------------------------------------------NGPT-EPRPP--------------------------------- E_caballus_ENSECAP00000011798 -----------------------------------------------------------------------------NGPT-DPRPP--------------------------------- B_taurus_ENSBTAP00000018453 -----------------------------------------------------------------------------NGPT-DPRPP--------------------------------- P_troglodytes_ENSPTRP00000006707 -----------------------------------------------------------------------------SGPT-DPRPP--------------------------------- X_tropicalis_ENSXETP00000055326 -----------------------------------------------------------------------------AGGETRT------------------------------------ M_musculus_ENSMUSP00000025867 -----------------------------------------------------------------------------NGPT-EPRPP--------------------------------- C_familiaris_ENSCAFP00000006862 -----------------------------------------------------------------------------HGIESK------------------------------------- B_taurus_ENSBTAP00000049624 -----------------------------------------------------------------------------HGIESK------------------------------------- D_melanogaster_FBpp0088375 -----------------------------------------------------------------------------KTLGLAQPPNGLPNLSQHDQTISEEFGREKHLNEFIA------ A_aegypti_AAEL006930-PA -----------------------------------------------------------------------------KDMQHAASMEPKERMIKIEPMDSH------------------- A_gambiae_AGAP006747-PA -----------------------------------------------------------------------------TSLTTSAHHPDIMSGIGSTTTISKELTKASIIQEILN--IPTT 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000226574 EPSEATVGNGEVTLTYATGTKEESAGVQ-----------------------------------DNLF---LEKAMQLAKRHANALFDYAVTGD-------VKMLLAV-----------QR P_troglodytes_ENSPTRP00000028033 EPSEATVGNGEVTLTYATGTKEESAGVQ-----------------------------------DNLF---LEKAMQLAKRHANALFDYAVTGD-------VKMLLAV-----------QR M_mulatta_ENSMMUP00000034946 EPSEATDGNGEVTLTYATRAKEESARVQ-----------------------------------DNLF---LEKAMQLAKRHANALFDYAVTGD-------VKMLLAV-----------QR P_pygmaeus_ENSPPYP00000016712 EPSEATDGNGEVTLTYATGTKEESAGVQ-----------------------------------DNLF---LEKAMQLAKRHANALFDYAVTGD-------VKMLLAV-----------QR C_familiaris_ENSCAFP00000015815 ESS---MGVDEVTLTYTVGIKEENSRFQ-----------------------------------DNLF---LEKAMQLAKRHANALFDYAVTGD-------VKMLLAV-----------QR B_taurus_ENSBTAP00000027016 GSC---KGGSAANLTCSVGVKEENRSFQ-----------------------------------DNLF---LEKAMQLAKQHANALFDYAVTGD-------VKMLLAV-----------QR E_caballus_ENSECAP00000013133 GSR---GRALLLSGVCVMGLGHPSHCLA-----------------------------------DNLF---LEKAMQLAKRHANALFDYAVTGD-------VKMLLAV-----------QR M_musculus_ENSMUSP00000029812 MAC---TKTEPIALASTMEDKEQDMGFQ-----------------------------------DNLF---LEKALQLARRHANALFDYAVTGD-------VKMLLAV-----------QR R_norvegicus_ENSRNOP00000028944 MAS---TKTEAIAPASTMEDKEEDVGFQ-----------------------------------DNLF---LEKALQLAKRHANALFDYAVTGD-------VKMLLAV-----------QR M_domestica_ENSMODP00000025861 KPR--VTGRDEITLTCTV-VEEEDCRLQ-----------------------------------GDPF---LEKAMQLAKRHASALFDYAVTGD-------VKVLLAV-----------QR T_guttata_ENSTGUP00000003727 RTSAVNEKKEDSVFSCKTEASEADCRWR-----------------------------------DALF---LEKAMQLARRHCNALFDYAVTGD-------VKMLLAA-----------QR G_gallus_ENSGALP00000020084 RTSGHNEEKEDASLCCKDEGNKPKCGCQ-----------------------------------DGLF---LEKAMQLAKRHCNALFDYAVTGD-------VRMLLAV-----------QR A_carolinensis_ENSACAP00000015967 FSL----NVQLHMLICTLFMRWLSFLPA-----------------------------------DALF---LEKAMELAKYHANALFDYAITGD-------VKRLLAV-----------QR X_tropicalis_ENSXETP00000046127 ------------NEEAPAREEREFCKLH-----------------------------------DCNF---PRNALQLTKRHAASLFDYAVTGD-------VRMLLAV-----------QR T_nigroviridis_ENSTNIP00000005249 ---------GIGSHWLDPRPPET-----------------------------------------------AGAVLEVTSGQVEALFRYSVTGE-------AAHLLAT-----------QR G_aculeatus_ENSGACP00000022290 --------KEGEVGGEEPEPPRGTHLLM-----------------------------------YTLF---TVTPLQMRCDQLQALFQYSVTGD-------SAFLLAA-----------QR G_gorilla_ENSGGOP00000008878 XXXXXXXXXXXXXXXXXXXXXXXXXXXX-----------------------------------XNLF---LEKAMQLAKRHANALFDYAVTGD-------VKMLLAV-----------QR T_rubripes_ENSTRUP00000010369 ---------------------VVMTTRH-----------------------------------GVLC---IHAVSQSARQTAAALLQYCSTGD-------ARVLLAV-----------QR G_aculeatus_ENSGACP00000001732 -----------------------RCPDG-----------------------------------DSLQ---GSRASQGARRTAAALLQYCSTGD-------ARVLLAI-----------QR A_carolinensis_ENSACAP00000014173 ------------------------LLQH-----------------------------------AQEC---SSWMLMLARRSARALLDYAVTAD-------PRMLLAV-----------QR T_guttata_ENSTGUP00000007782 ------------------------LQKH-----------------------------------EAHNPRRTGNLLGLSRRNAHALLDYSVTAD-------PRMLLAV-----------QR C_familiaris_ENSCAFP00000014918 ------------------------LLQR-----------------------------------AREY---NARLFGLAQRSARALLDYGVTAD-------ARALLAG-----------QR M_musculus_ENSMUSP00000072859 ------------------------TLQR-----------------------------------AREY---NARLFGLAQRSARALLDYGVTAD-------ARALLAG-----------QR B_taurus_ENSBTAP00000007904 ------------------------LLHR-----------------------------------AREY---NARLFGLAQRSARALLDYGVTAD-------ARSLLAG-----------QR M_mulatta_ENSMMUP00000003997 ------------------------MLQR-----------------------------------AREY---NARLFCLAQRSARALLDYGVTAD-------ARALLAG-----------QR E_caballus_ENSECAP00000017595 ------------------------LLQQ-----------------------------------AREY---NERLFGLARRSARALLDYGVTAD-------ARALLAG-----------QR H_sapiens_ENSP00000358983 ------------------------MLQR-----------------------------------AREY---NARLFGLAQRSARALLDYGVTAD-------ARALLAG-----------QR T_nigroviridis_ENSTNIP00000016350 ----------------------------------------------------------------TAL---HHSTSQRAQQTAAGLLQYCSSGD-------TRVLLAV-----------HT R_norvegicus_ENSRNOP00000026235 ------------------------TLQR-----------------------------------AREY---NARLFGLAQRSARALLDYGVTAD-------ARALLAG-----------QR O_latipes_ENSORLP00000003676 ----------------------------------------------------------------ATL---NNRVSQSARQTAAALLQYCRTGD-------TRALLAI-----------QT D_rerio_ENSDARP00000057671 ------------------------------------------------------------------L---HNRANLAAKCNARALLQYSSTGD-------ARPLLAL-----------QR D_rerio_ENSDARP00000056498 ------------------------------------------------------------------L---HNRANLAAKCNARALLQYSSTGD-------ARPLLAL-----------QR P_pygmaeus_ENSPPYP00000003023 ------------------------MLQR-----------------------------------AREY---NARLFGLAQRSARALLDYGVTAD-------ARALLAG-----------QR X_tropicalis_ENSXETP00000000018 ------------------------IMHQ-----------------------------------ANLC---NMRMLSLTQRTSRALLDYAITAD-------PRMLLAV-----------QR C_intestinalis_ENSCINP00000014252 FSTVQSDCCNVEADAAMLKMEKLSLAPSMPTKLDSLKPEKKFDSKQVETKTKGPLKRPVTSTTASVTQALEKYAVKTMNRNSSALHDFSVTGD-------IRMLLVL-----------QR P_troglodytes_ENSPTRP00000005089 ------------------------MLQR-----------------------------------AREY---NARLFGLAQRSARALLDYGVTAD-------ARALLAG-----------QR G_gorilla_ENSGGOP00000006827 ------------------------MLQR-----------------------------------AREY---NARLFGLAQRSARALLDYGVTAD-------ARALLAG-----------QR O_cuniculus_ENSOCUP00000004978 ------------------------MLQR-----------------------------------AREY---NARLFGLAQRSSLAGLRH---HG-------GRSLLAG-----------QR A_aegypti_AAEL007624-PA IAGDISFSSNDFKEFVNCNSEELRKLITEIGEAQEESKL------------------------ETDAVSV-GHVDEAAAQFERTLEQYLEHNSQAKDVEILKKILAIIRLLFRKNYDQCR M_mulatta_ENSMMUP00000037540 ----------------------------------------------------------------------------------------------------------------------PR M_domestica_ENSMODP00000011996 ----------------------------------------------------------------------------------------------------------------------PR C_familiaris_ENSCAFP00000019655 ----------------------------------------------------------------------------------------------------------------------PR P_pygmaeus_ENSPPYP00000003533 ----------------------------------------------------------------------------------------------------------------------PR H_sapiens_ENSP00000384273 ----------------------------------------------------------------------------------------------------------------------PR R_norvegicus_ENSRNOP00000044552 ----------------------------------------------------------------------------------------------------------------------PR E_caballus_ENSECAP00000011798 ----------------------------------------------------------------------------------------------------------------------PR B_taurus_ENSBTAP00000018453 ----------------------------------------------------------------------------------------------------------------------TR P_troglodytes_ENSPTRP00000006707 ----------------------------------------------------------------------------------------------------------------------PR X_tropicalis_ENSXETP00000055326 ----------------------------------------------------------------------------------------------------------------------PR M_musculus_ENSMUSP00000025867 ----------------------------------------------------------------------------------------------------------------------TR C_familiaris_ENSCAFP00000006862 ----------------------------------------------------------------------------------------------------------------------RR B_taurus_ENSBTAP00000049624 ----------------------------------------------------------------------------------------------------------------------RR D_melanogaster_FBpp0088375 --------SEDFRKLIEHNSSDLEKICQLDMGE------------------------------LQHDGHNRAEVPSHRNRTIKCLDDLFEIYKQD-----RISPIKI-----------SH A_aegypti_AAEL006930-PA ------------------------------------------------------------------------FQQQYTAQNAYRNPTESPDGN-------MTPMTAA-----------SP A_gambiae_AGAP006747-PA IASDVAFDSSDFP----CNSEEFNKLIQEIGNQQDLVKL------------------------ETDAETAGGGATDTESVLGRAIADLVASGDDSRQGEMLRKLLALIK-LFAGDVNRSR 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000226574 HLT-------AVQDENGDSVLHLAI--IHLHSQLVR-DLLEVTSGLIS-DDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAK-EG--HDKVLSILLKH-- P_troglodytes_ENSPTRP00000028033 HLT-------AVQDENGDSVLHLAI--IHLHSQLVR-DLLEVTSGLIS-DDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAK-EG--HDKVLSILLKH-- M_mulatta_ENSMMUP00000034946 HLT-------AVQDENGDSVLHLAI--IHLHSQLVR-DLLEVTSGLIS-DDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAK-EG--HDKVLSILLKH-- P_pygmaeus_ENSPPYP00000016712 HLT-------AVQDENGDSVLHLAI--IHLHSQLVR-DLLEVTAGLIS-DDIINMRNDLYQTPLHLAVITNQEDVVEDLLRAGADLSLLDRLGNSVLHLAAK-EG--HDKVLSILLKH-- C_familiaris_ENSCAFP00000015815 HLT-------AVQDENGDSVLHLAI--IHLHAQLVR-DLLEVTSGLIS-DDIINMRNDLYQTPLHLAVITKQEAVVDDLLRAGADLSLLDRLGNSVLHLAAK-EG--QDKILSILLKH-- B_taurus_ENSBTAP00000027016 HLT-------AVQDENGDSVLHLAI--IHLHNQLVR-DLLEVTSGLIS-DEIINMRNDLYQTPLHLAVITRQEAVVEDLLRAGADLSLLDRLGNSVLHLAAK-EG--HDKILGILLKH-- E_caballus_ENSECAP00000013133 HLT-------AVQDENGDSVLHLAI--IHLHAQLVR-DLLEVTSGLVS-DDIINMRNDLYQTPLHLAVITKQEAVVEDLLRAGADLSLLDRFGNSALHLAAK-EG--HDKILGILLKH-- M_musculus_ENSMUSP00000029812 HLT-------AVQDENGDSVLHLAI--IHLHAQLVR-DLLEVTSGLIS-DDIINMRNDLYQTPLHLAVITKQEDVVEDLLRVGADLSLLDRWGNSVLHLAAK-EG--HDRILSILLKS-- R_norvegicus_ENSRNOP00000028944 HLT-------AVQDENGDSVLHLAI--IHLHAQLVR-DLLEVTSGSIS-DDIINMRNDLYQTPLHLAVITKQEDVVEDLLRVGADLSLLDRWGNSVLHLAAK-EG--HDKILGVLLKN-- M_domestica_ENSMODP00000025861 HLT-------AVQDDNGDNVLHLAI--IHLHAELVR-NLLEVISGLLS-DDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADVSLLDRLGNSALHLAAK-EG--DDKILNILLKH-- T_guttata_ENSTGUP00000003727 HLT-------AVQDDNGDNVLHLAI--IHLHRDLVK-NLLEVMPDLNY-NDIINMRNDLYQTPLHLAVITKQAKVVEDLLKAGADVSLLDRHGNSVLHLAAT-EG--DDKILSLLLRH-- G_gallus_ENSGALP00000020084 HLT-------AVQDDNGDNVLHLSI--IHLHRELVK-NLLEVMPDMNY-NNIINMRNDLYQTPLHLAVITKQAEVVEDLLKAGANVNLLDRHGNSVLHLAAA-EG--DDKILSLLLKH-- A_carolinensis_ENSACAP00000015967 HLT-------TAQDENGDNVLHLSI--IHLQAELMR-NLLEVIADLNS-ADVLDVRNDLYQTPLHLAVITKQAGAVRDLLGTGADVSLLDRHGNSVLHLAVN-QG--DEKVLNILLSH-- X_tropicalis_ENSXETP00000046127 HLA-------SVQDENGDNILHLSI--IHQHSALVR-IFLDITQGPVC-DDIINVRNDLYQTPLHLAVITQQPDTVQDIIKAGGDPLCLDRDGNSVLHLACK-EG--DASTLSILLKH-- T_nigroviridis_ENSTNIP00000005249 SLM-------DAQDEDGDSVLHLAV--LHHQQEVLK-SLVQVLSLLPG-QDVLNARNHLYQTPLHLAVLTQQREAVQALLLAGADPTLADRHGNTPLHLASQQGG--DGGMVGFLLQD-- G_aculeatus_ENSGACP00000022290 QLM-------SVQDEDGDTGLHLAV--LHSQQEALK-SLTQVVSALPG-EEVLNMRNHLYQSPLHLAVITQQREAVEALLLAGADPTLTDRHGNTPLHLASRVEG--GGGMVQFLLQH-- G_gorilla_ENSGGOP00000008878 HLT-------AVQDENGDSVLHLAI--IHLHSQLVR-DLLEVTSGLIS-DDIINMRNDLYQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XX--XXXXXXXXXXX-- T_rubripes_ENSTRUP00000010369 HLC-------GVQDTNGDTPLHLAI--IHQQTGVIQ-QLIQTLLSSQQ-QNILNTANHLLQTPLHLAVITRQVKVVEMLLRAGVDPSLLDKDGRSPVHLASL-AG--DSAVLRLLLAHLK G_aculeatus_ENSGACP00000001732 HLC-------GVQDGNGDTPLHLAV--IHQQTGVIQ-QLIHTLLSSQQ-QNILNTANHLQQTPLHLAVITRQVKVLEVLLRAGADPSLLDKDGRNPLHLAAL-AG--DTASLRLLLAHLG A_carolinensis_ENSACAP00000014173 HLA-------ASQDENGDTPLHLAV--IHEQTAVIA-QLVQVAVSIPN-QQIINIANHLQQTPLHLAVITRQPRVAGFLLQAGADPTLLDRYGNSIIHLALQ-LG--EEEMLRTLLCHLG T_guttata_ENSTGUP00000007782 HLA-------ASQDENGDTPLHLAI--IHEQTAVIK-QLIDIIVSIPH-QQIINISNNLQQTSLHLAVITKQPQVVQLLLQAHADPTLLDRYGNSLLHLALQ-TG--DEEMLRTLLAHLG C_familiaris_ENSCAFP00000014918 HLL-------TAQDENGDTPLHLAI--IHGQTSVIE-QIAHVIYHARH-LGVVNLTNHLHQTPLHLAVITGQTSVVSFLLQVGADPALLDRHGDSAVHLALR-AGTSAPDLLRALLRSGV M_musculus_ENSMUSP00000072859 HLL-------MAQDENGDTPLHLAI--IHGQTGVIE-QIAHVIYHAQY-LGVINLTNHLHQTPLHLAVITGQTRVVSFLLQVGADPTLLDRHGDSALHLALR-AGAAAPELLQALLRSGA B_taurus_ENSBTAP00000007904 HLL-------TAQDENGDTPLHLAI--IHGQTTVIE-QIAHVIYHAPH-LGVVNITNHLHQTPLHLAVITGQTKVVSFLLQVGADPALLDRHGDSAVHLALR-AGASAPDMLCALLRSGV M_mulatta_ENSMMUP00000003997 HLL-------TAQDENGDTPLHLAI--IHGQTSVIE-QIAYVIHHAQD-LGVVNLTNHLHQTPLHLAVITRQTSVVSFLLRVGADPALLDRHGDSAMHLALR-AGAGAPELLRALLQSGA E_caballus_ENSECAP00000017595 HLL-------TAQDENGDTPLHLAI--IHGQTSVIE-QIAHVIYHAQH-LGVVNLTNHLHQTPLHLAVITGQTRVVSFLLQVGADPALLDRHGDSAVHLALR-VGAGAPDLLRALLQSGV H_sapiens_ENSP00000358983 HLL-------TAQDENGDTPLHLAI--IHGQTSVIE-QIVYVIHHAQD-LGVVNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALR-AGAGAPELLRALLQSGA T_nigroviridis_ENSTNIP00000016350 HLC-------SVQDTNGDTPLHLAV--IHQQTAVVH-QLVQTLLSSRQ-PGVLNTANHLLQTPLHLAVITRQVKVVELLLRAGVDPSLPDKDGRTPVHLAAS-AG--DSATLRLLLAHLG R_norvegicus_ENSRNOP00000026235 HLL-------MAQDENGDTPLHLAI--IHGQTGVIE-QIAQVIYHAQY-LGVINLTNHLHQTPLHLAVITGQTRVVSFLLQVGADPTLLDRHGDSAVHLALR-AGAAAPDLLQAVLHSGA O_latipes_ENSORLP00000003676 HLC-------SVQDTNGDTPLHLSI--IHLQTGVTQ-QLIHTLLSSRQ-QRILNTTNHLQQTPLHLAVITRQPKVVEALLRAGADPTLPDKDGRSPLHLAAL-AG--DSSLLRLLLSHMG D_rerio_ENSDARP00000057671 HLC-------GVQDENGDTPLHLAI--IHQKTVVAE-QLIKALNSSPQ-QKFFNKLNKLSQAPLHLAVITKQPKLVEMLMKSGADPSLLDREGRTVLHLAAH-TG--DDVILRLVLSLLG D_rerio_ENSDARP00000056498 HLC-------GVQDENGDTPLHLAI--IHQKTVVAE-QLIKALNSSPQ-QKFFNKLNKLSQAPLHLAVITKQPKLVEMLMKSGADPSLLDREGRTVLHLAAH-TG--DDVILRLVLSLLG P_pygmaeus_ENSPPYP00000003023 HLL-------TAQDENGDTPLHLAI--IHGQTSVIE-QIAYVIHHAQD-LGVVNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALR-AGAGAPELLRALLQSGA X_tropicalis_ENSXETP00000000018 HLI-------ATQDENGDTPLHLAV--IHGQPSVIE-QLVQVIISIPN-QQILNMSNHLQQTPLHLGVITKQYSVVAFLLKAGADPTILDRYGNSVLHLAVQ-AE--DDKMLSVLLKYPS C_intestinalis_ENSCINP00000014252 HLT-------DVRDCNGDSVLHVAV--IHDQMQVLS-SLLDVIVTLNNKQNIIDAVNPQKQTALQMAVLSDN--VDADLLKVGADPLVLDSYGNHSIHVACR-HG--NADILNRLLNC-K P_troglodytes_ENSPTRP00000005089 HLL-------TAQDENGDTPLHLAI--IHGQTSVIE-QIVYVIHHAQD-LGVVNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALR-AGAGAPELLRALLQSGA G_gorilla_ENSGGOP00000006827 HLL-------TAQDENGDTPLHLAI--IHGQTSVIE-QIVYVIHHAQD-LGVVNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALR-AGAGAXELLXALLXSGA O_cuniculus_ENSOCUP00000004978 HLL-------TAQDENGDTPLHLAI--IHGQTSVIE-QISHVIYHAQH-LGVVNLTNHLHQTPLHLAVITGQTRVVSFLLQVGADPALLDRHGDSAVHLALR-AGAGAPELLRALLCSGA A_aegypti_AAEL007624-PA ELISALW---MSANKLKANCLHMAI--ERRNITIAC-KLVELLQDHHL-LDMLDLFNERNETALHLAVSANLVEVVDVLLLTGSRISYCDSRGNSALHRAVY-EN--ALDSLNVLLGH-C M_mulatta_ENSMMUP00000037540 RIA-------VP---------------SRSSV-VPK-PAPQPYPFTSS--------------------------------LSTINYDEFPTMVFPSGQI-SQ-ASALAP--PQVLPQ--- M_domestica_ENSMODP00000011996 RIA-------VP---------------SRTTGSTPKPPVPQPYTFPPP--------------------------------LSTINLEELSPIVFSASQVQAP-ALASAPTPAP------- C_familiaris_ENSCAFP00000019655 RIA-------VP---------------SRSTTSVPK-PAPQSYPFTPS--------------------------------LSTINFEEFSPMVFSSGQISSQ-TSALASAPAPAPIL--- P_pygmaeus_ENSPPYP00000003533 RIA-------VP---------------SRSSASVPK-PAPQPYPFTSS--------------------------------LSTINYDEFPTMVFPSGQI-SQ-ASALAPAPPQVLPQ--- H_sapiens_ENSP00000384273 RIA-------VP---------------SRSSASVPK-PAPQPYPFTSS--------------------------------LSTINYDEFPTMVFPSGQI-SQ-ASALAPAPPQVLPQ--- R_norvegicus_ENSRNOP00000044552 RIA-------VP---------------SRGPTSVPK-PAPQPYAFSTS--------------------------------LSTINFDEFSPMVLPPGQISNQ-ALALAPSSAPVLAQ--- E_caballus_ENSECAP00000011798 RIA-------VP---------------ARSSASVPK-PAPQPYPFTPS--------------------------------LSTINFEEFSPMVFPSGTIPSQ-TSALAPAPAPVLAQ--- B_taurus_ENSBTAP00000018453 RIA-------VP---------------NRGSASIPK-PAPQPYSFTPS--------------------------------LSTINFEEFSPMVFPSGQIPSQ-TSALAPAPTPVLTQ--- P_troglodytes_ENSPTRP00000006707 RIA-------VP---------------SRSSASVPK-PAPQPYPFTSS--------------------------------LSTINYDEFPTMVFPSGQI-SQ-ASALAPAPPQVLPQ--- X_tropicalis_ENSXETP00000055326 RIA-------VP---NRIVPTKSAS--IRPSPSVPN-PMVPSLSFSMP-------------------VLKVDSVTSASTRLSTVNISDFSNLGFSSQPPPQS-----DPDRIE------- M_musculus_ENSMUSP00000025867 RIA-------VP---------------TRNSTSVPK-PAPQPYTFPAS--------------------------------LSTINFDEFSPMLLPSGQISNQ-ALALAPSSAPVLAQ--- C_familiaris_ENSCAFP00000006862 RKK-------PA------FLDHFLP--NSSSGPFLPPSALLPDTDFFP---------------------------------GTVSLPGLEPPGGPDLLDDSF-AY--DDSTAPTLFTM-- B_taurus_ENSBTAP00000049624 RKK-------PV------FLDQFLP--SHGSGPYLPPSVLLPDTDFYP---------------------------------GTVSLPSLEPPGGPDLLDDSF-PY--DPA-APTLLTM-- D_melanogaster_FBpp0088375 HKVEKWFIEHALNNYNRDTLLHEVISHKKDKLKLAI-QTIQVMNYFNLKDVVNSTLNADGDSALHVACQQDRAHYIRPLLGMGCNPNLKNNAGNTPLHVAVK-EE--HLSCVESFLNG-V A_aegypti_AAEL006930-PA YEG-------AIGYQAGN---EYYVVNHRYQSNYNNFSVGGPSNGYQQ--------YHYQQTGVHYGMNN----------LAGASLPVNGQQGFNLQQQQSQ-----MPDNLDCLL---- A_gambiae_AGAP006747-PA QLLASHW---TAANQQQLNCLHAAI--RRNDTTIAC-KLIELLHEYQLAEELLDLPNDRNETGLHLAVSCNSEPIVKALLGAGAKLHYCDYRGNTPLHRAVV-EN--VPDMVRLLL---- 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000226574 KKAALLLDHPNGDGLNAIHLAMMSNS--LPCLLLLVAAG-ADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVD----STTYDGTTPLHIAAGR-----GSTR-LAALLKAAGAD P_troglodytes_ENSPTRP00000028033 KKAALLLDHPNGDGLNAIHLAMMSNS--LPCLLLLVAAG-ADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVD----STTYDGTTPLHIAAGR-----GSTR-LAALLKAAGAD M_mulatta_ENSMMUP00000034946 KKAALLLDHPNGDGLNAIHLAMMSNS--LPCLLLLVAAG-ADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVD----STTYDGTTPLHIAAGR-----GSTR-LAALLKAAGAD P_pygmaeus_ENSPPYP00000016712 RKAALLLDHPNGDGLNAIHLAMMSNS--LPCLLLLVAAG-ADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVD----STTYDGTTPLHIAAGR-----GSTR-LAALLKAAGAD C_familiaris_ENSCAFP00000015815 KKAALLMDHPNGEGLNAIHIAVMSNS--MPCLLLLVAAG-ADVNAQERKSGRTALHLAVEHDNISLAGCLLLEGDAHVD----STTYDGTTPLHIAAGR-----GSTR-LAALLKAAGAD B_taurus_ENSBTAP00000027016 KKAAQLIDHPNGEGLNAIHVAMMSNS--LPCLLLLMAAG-ADVNAQERKSGRTALHLAVEHDNVSLAGCLLLEGDAHVD----STTYDGTTPLHIAAGR-----GSTR-LAALLKAAGAD E_caballus_ENSECAP00000013133 KKAALLINHPNADGLNAIHIAMMSNS--MPCLRLLVTAG-ADVNAQERKSGRTALHLAVERDNISLAGCLLLEGEAHVD----STTYDGTTPLHIAAGR-----GSTR-LAALLKAAGAD M_musculus_ENSMUSP00000029812 RKAAPLIDHPNGEGLNAIHIAVMSNS--LPCLLLLVAAG-AEVNAQEQKSGRTALHLAVEYDNISLAGCLLLEGDAHVD----STTYDGTTPLHIAAGR-----GSTR-LAALLKAAGAD R_norvegicus_ENSRNOP00000028944 SKAALLINHPNGEGLNAIHIAVMSNS--LSCLQLLVAAG-AEVNAQEQKSGRTALHLAVEYDNISLAGCLLLEGDALVD----STTYDGTTPLHIAAGR-----GSTR-LAALLKAAGAD M_domestica_ENSMODP00000025861 KKILPLIDHPNGEGLNAIHLAMLINS--MPCLRLMIAAG-ADVNAQEQTSGRTALHLAVEQENVSLAGCLLLEGDAFVD----STTYDGTTPLHIAAGR-----GSTK-LAALLKAAGAD T_guttata_ENSTGUP00000003727 ENVSPMVNLPNAEGLSAIHMVVMANS--MSCLKQLIAAG-VNVNAQEQKSGRTALHLAVEQENIPLAGCLLLEGDADVD----STTYDGTTPLHIAAGR-----GSTK-LAAVLKAAGAN G_gallus_ENSGALP00000020084 QKASSMIDLSNGEGLSAIHMVVTANS--LSCLKLLIAAG-VDVNAQEQKSGRTALHLAVEQENVPLAGCLLLEGDADVD----STTYDGTTPLHIAAGR-----GFTK-LAAVLKAAGAD A_carolinensis_ENSACAP00000015967 KEASQMKDLPNGEGLAAIHLAVMANS--VSCLRRLFAAG-VDVNAQEQKSGKTALHLAVEQGSISLAGCLLLEGEAFVD----STTYDGTTPLHIAAGR-----GSTK-LTALLKAAGAD X_tropicalis_ENSXETP00000046127 KKTLEIINLPNNDGLNPIHVAVLSNC--VLCLRLLISAR-ADVNAQEQKSGKSALHLAVEQDNISLAGCLLLEGDACVD----NTTYDGNTPLHIAVGR-----GSTK-LTALLKAAGAD T_nigroviridis_ENSTNIP00000005249 EGMRGLLELPNRAGLCPIHLAVLANQ--LSSLRELLEGG-ANVESQERSCGRSALHLATERDNVSLAGCLLLEGNANVD----SCTFDGSTPLHVAAGR-----GSAK-LTALLVAAGAD G_aculeatus_ENSGACP00000022290 REMIVRLSVSTVTGLCAIHLAVLANQ--LSSLRELLEGG-ANVEAQERSCGRTALHLATERDNVSLAGCLLLEGNAKVD----SFTFNGSTPLHIAAGR-----DSVK-LTALLMAAGAD G_gorilla_ENSGGOP00000008878 XXXXXXXXXXXXXXLNAIHLAMMSNS--LPCLLLLVAAG-ADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVD----STTYDGTTPLHIAAGR-----GSTR-LAALLKAAGAD T_rubripes_ENSTRUP00000010369 ASWVF-----PGSGLHPLHLAVRRDG--ERCLRLLVEGG-AKINAPEQKSGNTALHLAVRENLFKVACTLITELKAEVN----ACSFGGNTPLHLAASL-----GSPT-LCSMLVAAGAD G_aculeatus_ENSGACP00000001732 ERHAHLVNTADYHGLHPLHLSVRRDG--ERCLRLLVEGG-AKINAPEQKSGNTALHLAVRENLFKVACTLITELKADVN----TTTFGGNTPLHLAAGL-----GSPT-LCSMLIAAGAD A_carolinensis_ENSACAP00000014173 PHTLHLLETPNYLGLFPVHLAVKCKR--LTCLELLVEKG-ADVNAAERQSGRTPLHLAVEMENLNLATCLIKKLGADVN----AQTSAGNTPLHLAAGM-----GSPI-LTKMLIKAGAD T_guttata_ENSTGUP00000007782 SAAPYLLCLPNFHGLLPVHLAVKAKS--LACLDLLVRTG-ADVNAVERQSGRTPLHLAVDMENLNMATHLVKKLGADIN----SRNFAGNTPLHLAAGL-----GSPT-LTKLLLKAGAD C_familiaris_ENSCAFP00000014918 PTMPQLLHMPDFEGLYPVHLAVRARS--PECLDLLVDSG-AEVEAAERQGGRTALHLATEMEELGLVTHLVTKLRANVN----ARTFAGNTPLHLAAGL-----GSPT-LTRLLLKAGAD M_musculus_ENSMUSP00000072859 HAVPQILHMPDFEGLYPVHLAVHARS--PECLDLLVDCG-AEVEAPERQGGRTALHLATEMEELGLVTHLVTKLHANVN----ARTFAGNTPLHLAAGL-----GSPT-LTRLLLKAGAD B_taurus_ENSBTAP00000007904 PAMPQLLHVPDFEGLYPVHLAVRARS--PECLDLLVESG-AEVEAAERQGGRTALHLATEMEELGLVTHLVTKLRANVN----ARTFAGNTPLHLAAGL-----GSPT-LTRLLLKAGAD M_mulatta_ENSMMUP00000003997 PAVPQLLHMPDFEGLYPVHLAVRARS--PECLDLLVDSG-AEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVN----ARTFAGNTPLHLAAGL-----GYPT-LTRLLLKAGAD E_caballus_ENSECAP00000017595 PAMPQLLHLPDFEGLYPVHLAVRARS--PECLDLLVDNG-AEVEAAERQGGRTALHLATEMEELGLVTHLVTKLRANVN----ARTFAGNTPLHLAAGL-----GSPT-LTRLLLKAGAD H_sapiens_ENSP00000358983 PAVPQLLHMPDFEGLYPVHLAVRARS--PECLDLLVDSG-AEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVN----ARTFAGNTPLHLAAGL-----GYPT-LTRLLLKAGAD T_nigroviridis_ENSTNIP00000016350 ESHAHVVNSPDYHGLRPLHLAVRRDG--ERCLRLLVEGG-AKINAPEQKSGHTALHQAVKENLFKVACTLITELKADVN----ACTFGGNTPLHLAASQ-----GSPT-LCSMLVAAGAD R_norvegicus_ENSRNOP00000026235 HALPQMLHMPDFEGLYPVHLAVHARS--PECLDLLVDCG-AEVEAAERQGGRTPLHLATEMEELGLVTHLVTKLHANVN----ARTFAGNTPLHLAAGL-----GSPT-LTRLLLKAGAD O_latipes_ENSORLP00000003676 ERHSHLVNTPDYHGLQPLHLAVRRDG--ERCLRLLIEGG-AKINAPEQKSGNTALHLAVRENLFKVACTLITELKADTN----ACTFGGNTPLHLAASL-----GSPT-LCSMLIAAGAD D_rerio_ENSDARP00000057671 EHHSHLINSADFTGQYPVHLAVKKDG--ERCLRLLVEAG-AKINMPEQKSGCTALHLAVRDNLLKLACNLITELKADVN----ACTYGGNSPLHLAASQ-----GSPH-LCSMLIAAGAD D_rerio_ENSDARP00000056498 EHHSHLINSADFTGQYPVHLAVKKDG--ERCLRLLVEAG-AKINMPEQKSGCTALHLAVRDNLLKLACNLITELKADVN----ACTYGGNSPLHLAASQ-----GSPH-LCSMLIAAGAD P_pygmaeus_ENSPPYP00000003023 PAVPQLLHMPDFEGLYPVHLAVRARS--PECLDLLVDSG-AEVEATERQGGRTALHLATEMEELGLVTHLVTK------------------------------------------KGGAD X_tropicalis_ENSXETP00000000018 VGQKDLLNMPDYHGLCPVHWSVKMKN--EKCLELLVKAG-ANVNSPERKSGKSPLHIAVEMDNLNMAIFLVKKSHADIN----AKTYGGNTPLHLAASR-----GSPM-LTKMLVNEGAN C_intestinalis_ENSCINP00000014252 QVYDMEMDTKNFDGLGCFHLAGKASSGTRQCLGLLREFA-FDVNMPDMKSRRTALHMAVEADNIVVAGCLISECDADLE----ASTYEGYTPLHVAASL-----DHCE-IATLLLACGAD P_troglodytes_ENSPTRP00000005089 PSVPQLLHMPDFEGLYPVHLAVRARS--PECLDLLVDSG-AEVEATERQGGRTALHLATEMEELGLVTHLVTK----------------------------------------------- G_gorilla_ENSGGOP00000006827 PAVPQLLXMPDFEGLYPVHLAVRARS--PECLDLLVDSG-AEVEATERQGGRTALHLATEMEELGLVTHLVTKXXXXXX----XXXXXXXXXXXXXXXX-----XXXX-XXXXXXXXXAD O_cuniculus_ENSOCUP00000004978 PAVSQLLHMPDFEGLYPVHLAVHARS--PKCLD-LVDSG-AEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLHANVN----ARTFAGNTPLHLAAGL-----GSPT-LTRLLLKAGAD A_aegypti_AAEL007624-PA KRNGFRLDSTNDDGFTALHLAVMCKN--LKATKVLLDRG-ASYVLRDLKHGNNILHIAVESDSLDMVNFILEGVDKTLAD---EPNNAGYTPLQLANAR-HLANANNKLIVRELLRYNPS M_mulatta_ENSMMUP00000037540 -------------------------------APAPAPAPAMVSPLAQA----PVLAPGP------------------------PQAVAPPAPKPTQA-------GEGT-LSEALLQLQFD M_domestica_ENSMODP00000011996 ---------------------------------SLVPAP-----TSTAPAPAPAL------------------------------------PPISQS-------GEGT-LSEALLGLQFD C_familiaris_ENSCAFP00000019655 ---------------------------------APAPP---------APAPAPILAPGL------------------------AQAMAPPAPKTTQA-------GEGT-LTEALLQLQFD P_pygmaeus_ENSPPYP00000003533 -------------------------------ASAPAPAPAMVSALAQAPAPVPVLPPGP------------------------PQAVAPPAPKPTQA-------GEGT-LSEALLQLQFD H_sapiens_ENSP00000384273 -------------------------------APAPAPAPAMVSALAQAPAPVPVLAPGP------------------------PQAVAPPAPKPTQA-------GEGT-LSEALLQLQFD R_norvegicus_ENSRNOP00000044552 ---------------------------------TMVPSSAMVPSLAQPPAPVPVLAPGP------------------------PQSLSAPVPKSTQA-------GEGT-LSEALLHLQFD E_caballus_ENSECAP00000011798 ---------------------------------APAPAPAMASALAQAPAPVPVLAAGL------------------------AQAVAPPAPRTTQA-------GEGT-LTEALLQLQFD B_taurus_ENSBTAP00000018453 ---------------------------TQVLAPAPAPAPGMASTLAQA------LAPGL------------------------AQAVTPPAPRTNQT-------GEGT-LTEALLQLQFD P_troglodytes_ENSPTRP00000006707 -------------------------------APAPAPAPAMVSALAQAPAPVPVLAPGP------------------------PQAVAPPAPKPTQA-------GEGT-LSEALLQLQFD X_tropicalis_ENSXETP00000055326 ---------------------------------SFLNYP----------------------------------------------------------------------------SFSGD M_musculus_ENSMUSP00000025867 ---------------------------------TMVPSSAMVP-LAQPPAPAPVLTPGP------------------------PQSLSAPVPKSTQA-------GEGT-LSEALLHLQFD C_familiaris_ENSCAFP00000006862 -------------------------------LDMLPPAPPLASAVTGNGAAGPA-----------------------------VGEPSGPEPMTLDSYQ---APGPGDGGTASLVGSNMF B_taurus_ENSBTAP00000049624 -------------------------------LDMLPPAPPLTSAVAGNGGAGAA-----------------------------VGEPPGPEPLTLDSYQ---APGPGDGGTASLVGSNMF D_melanogaster_FBpp0088375 PTVQLDLSLTNDDGLTPLHMAIRQNK--YDVAKKLISYDRTSISVANTMDGNNALHMAVLEQSVELLVLILDAQNENLTDILQAQNAAGHTPLELAERK-----ANDR-VVQLLKNVYPE A_aegypti_AAEL006930-PA -----------------------------------------------------------------------------------DMELAKGFPMNSSE------------IKTMIGQIEPQ A_gambiae_AGAP006747-PA LQGGLRLDCTNDDGLTALQAAVYARN--LKITRILLEAG-ASVREKDLKHGNNILHIAVDNDALDIVHYILEEVKEELGR---ERNNAGYTPLQLADAKSHTGQGNNKLIVRELLRHYPD 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000226574 P---------------LVENFEPLYDLDDSWEN-AGEDEGV-------------------------------------------------VPGTTPLDMAT--S-WQ--------VFDIL P_troglodytes_ENSPTRP00000028033 P---------------LVENFEPLYDLDDSWEN-AGEDEGV-------------------------------------------------VPGTTPLDMAT--S-WQ--------VFDIL M_mulatta_ENSMMUP00000034946 P---------------LVENFEPLYDLDDSWEN-AGEDEGV-------------------------------------------------VPGTTPLDMAA--S-WQ--------VFDIL P_pygmaeus_ENSPPYP00000016712 P---------------LVENFEPLYDLDDSWEN-AGEDEGV-------------------------------------------------VPGTTPLDMAT--S-WQ--------VFDIL C_familiaris_ENSCAFP00000015815 P---------------LVENFEPLYDLDDSWEK-DGEDEGV-------------------------------------------------VPGTTPLDMAT--N-WQ--------VFDIL B_taurus_ENSBTAP00000027016 P---------------LVENFEPLYDLDDSWDE-DGEDEGV-------------------------------------------------VPGTTPLDMAS--S-WQ--------VFDIL E_caballus_ENSECAP00000013133 P---------------LVENFEPLYDLDDSWEE-NGEDEGV-------------------------------------------------VPGTTPLDMAT--S-WQ--------VFDIL M_musculus_ENSMUSP00000029812 P---------------LVENFEPLYDLDDSWEK-AGEDEGV-------------------------------------------------VPGTTPLDMAA--N-WQ--------VFDIL R_norvegicus_ENSRNOP00000028944 P---------------LVENFEPLYDLDDSWEK-AGEDEGV-------------------------------------------------VPGTTPLDMAA--N-WQ--------VFDIL M_domestica_ENSMODP00000025861 P---------------LLENFEPLYDLDDVWDQ-DGEDEGV-------------------------------------------------VPGTTPLDMAA--N-SQASG-----VYDIL T_guttata_ENSTGUP00000003727 P---------------HIENFEPLFDLDYVKED-EDDDEGI-------------------------------------------------VPGTTPLDMAA--N-SE--------VYDIL G_gallus_ENSGALP00000020084 P---------------HVENFEPLFDVEEDVKD-DDDDEGI-------------------------------------------------VPGTTPLDMAA--N-WE--------VYDIL A_carolinensis_ENSACAP00000015967 P---------------HIENFEPLFEQDDVKDN-EGEDEGI-------------------------------------------------VPGTTPLDMAT--T-MI--------VYDIL X_tropicalis_ENSXETP00000046127 S---------------FVENFEPLLRFEDTQDE-DDVDEGI-------------------------------------------------VPGTKPLDIAT--S-DEARGCCMFWVLEIL T_nigroviridis_ENSTNIP00000005249 P---------------RKENFEPLFFLQTSWLQ-SDKEEGY-------------------------------------------------VPGTTPMNIAA--TKQQ--------VVELL G_aculeatus_ENSGACP00000022290 P---------------QRENFEPLFFREEDCCDEEKEDEGY-------------------------------------------------IPGTTPLNMAT--T-AQ--------VLELL G_gorilla_ENSGGOP00000008878 P---------------LVENFEPLYDLDDSWEN-AGEDEGV-------------------------------------------------VPGTTPLDMAT--S-WQ--------XXXXX T_rubripes_ENSTRUP00000010369 K---------------NMENDEPLVCSSSSDED-EPDGETRQ--------------------------------------------AVTRKRGHTPLDLAN--C-QK--------VRNLL G_aculeatus_ENSGACP00000001732 K---------------NVENDEPLFFTSSSDEE-QDEDEPI-------------------------------------------------RGGHTPLHLTR--C-QKQ-------VRILL A_carolinensis_ENSACAP00000014173 I---------------HCENDEPMTATSSNSSNVGLIGDHK-----------------------------------------EPTPCKRQQRGHIPLDLTT--S-QK--------VREIL T_guttata_ENSTGUP00000007782 V---------------LCENDEPLSLSSSEASS-DTDTDPE-----------------------------------------EQEAGHRQRRCHTSLDLTR--S-HK--------VMPML C_familiaris_ENSCAFP00000014918 I---------------HAENEEPLCPLPSPPTS-GSDSDSE----------------------------------------GPERDARGSSRGHTPLDLTR--S-TK--------VKTLL M_musculus_ENSMUSP00000072859 I---------------HAENEEPLCPLPSPSTS-GSDSDSE----------------------------------------GPERDTQRNFRGHTPLDLTC--S-TK--------VKTLL B_taurus_ENSBTAP00000007904 V---------------HAENEEPLCPLPSPPTS-GSDSDSE----------------------------------------SPERDTRGSFRGHTPLDLTR--S-SK--------VKTLL M_mulatta_ENSMMUP00000003997 I---------------HAENEEPLCPLPSPPTS-DSDSDTE----------------------------------------GPEKDTRSSFRGHTPLDLTC--S-TK--------VKTLL E_caballus_ENSECAP00000017595 I---------------HAENEEPLCPLPSPPTS-DSDSDSE----------------------------------------GPERDIRSSFRGHTPLDLTR--S-SK--------VKTLL H_sapiens_ENSP00000358983 I---------------HAENEEPLCPLPSPPTS-DSDSDSE----------------------------------------GPEKDTRSSFRGHTPLDLTC--S-TK--------VKTLL T_nigroviridis_ENSTNIP00000016350 K---------------NVENDEPLLLSSSSDEE-EPEGDAPE-------ASQPIT-------------------------------RKRPAGGHTPLDLAS--C-QK--------VRNLL R_norvegicus_ENSRNOP00000026235 I---------------HAENEEPLCPLPSPPTS-GSDSDSE----------------------------------------GPETDTQRNFRGHTPLDLTR--S-TK--------VKTLL O_latipes_ENSORLP00000003676 K---------------NIQNDEPLSCSSSSDEE-VDESELTREELAERAASQPIN-------------------------------TRKRRAGHTPLDLAT--C-HK--------VRNLL D_rerio_ENSDARP00000057671 K---------------RIENDEPLFLSSSSSDE-DEESEKKL-------SEDMVQQVHCLSISSE---------------RGVFNPRKRPAAGHTPFDLAK--S-QK--------VRDLL D_rerio_ENSDARP00000056498 K---------------RIENDEPLFLSSSSSDE-DEESEKKL-------SEDMVQQVHCLSISSE---------------RGVFNPRKRPAAGHTPFDLAK--S-QK--------VRDLL P_pygmaeus_ENSPPYP00000003023 I---------------HAENEEPLCPLPSPPTS-DSDSDSE----------------------------------------GPEKDTRSSFRGHTPLDLTC--S-TK--------VKTLL X_tropicalis_ENSXETP00000000018 V---------------LSENDEPVNKLPSCNSD-TSESDSDVQMDTDSDHHGGSDTDSSTAVDSDCEHSAEEMHSKEQRGIRPHCAVKRRYPGHTALDLTK--S-QK--------VRDIL C_intestinalis_ENSCINP00000014252 P---------------EASSAPP----------------GR-------------------------------------------------EDGMTPLDLAT--S-DQ--------MRDLL P_troglodytes_ENSPTRP00000005089 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006827 I---------------HAENEEPLCPLPSPPTS-DSDSDSE----------------------------------------GPEKDTRSSFRGHTPLDLTC--S-TK--------VKTLL O_cuniculus_ENSOCUP00000004978 I---------------HAENEEPLCPLPSPPTS-GSDSDSE----------------------------------------GPERDTRSSFRGHTPLDLTR--S-TK--------VKTLL A_aegypti_AAEL007624-PA G----------------VLEKEHLTEEEDDDQE-QEENLPP-------------------------------------------SSDSQSETVLESMNVSC-NR-VE--------VIRLL M_mulatta_ENSMMUP00000037540 --------------------DEDLGALLGNSTD-----------------------------------------------------------PTVFTDLASVDN-SE--------FQQLL M_domestica_ENSMODP00000011996 T-------------------DGDLAEIL---AD----------------------------------------------------------PDSTYTNLAAIDN-SE--------FQQLL C_familiaris_ENSCAFP00000019655 A-------------------DEDLGALLGNSAD-----------------------------------------------------------PAVFTDLASVDN-SE--------FQQLL P_pygmaeus_ENSPPYP00000003533 --------------------DEDLGALLGNSTD-----------------------------------------------------------PAVFTDLASVDN-SE--------FQQLL H_sapiens_ENSP00000384273 --------------------DEDLGALLGNSTD-----------------------------------------------------------PAVFTDLASVDN-SE--------FQQLL R_norvegicus_ENSRNOP00000044552 A-------------------DEDLGALLGNNTD-----------------------------------------------------------PGVFTDLASVDN-SE--------FQQLL E_caballus_ENSECAP00000011798 A-------------------DEDLGALLGNNTD-----------------------------------------------------------PAVFTDLASVDN-SE--------FQQLL B_taurus_ENSBTAP00000018453 T-------------------DEDLGALLGNNTD-----------------------------------------------------------PAVFTDLASVDN-SE--------FQQLL P_troglodytes_ENSPTRP00000006707 --------------------DEDLGALLGNSTD-----------------------------------------------------------PAVFTDLASVDN-SE--------FQQLL X_tropicalis_ENSXETP00000055326 A-------------------NLDLVEMLPNDTE------------------------------------------------------------SRCTSLSSIDN-SD--------FSQLL M_musculus_ENSMUSP00000025867 A-------------------DEDLGALLGNSTD-----------------------------------------------------------PGVFTDLASVDN-SE--------FQQLL C_familiaris_ENSCAFP00000006862 P----------------------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000049624 P----------------------------------------------------------------------------------------------------------------------- D_melanogaster_FBpp0088375 K-------GELAMTWIPCKVKEEIDSSSDESSD-----------------------------------------------------AGQLEIKSEEMDIET--KDED--------SVELD A_aegypti_AAEL006930-PA R---------------MQQEEENL------------------------------------------------------------------------------------------------ A_gambiae_AGAP006747-PA GLQKEVKKEVDAAEDDEEEEEEEQEEEEDEDEEGGEEHGQR-------------------------------------------EASAPSSSVLDSMDLINGER-AS--------IARLL 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000226574 NGKPY--E---PEFTSDDLL---AQGDM--KQLAEDVKLQLYKLLEIPD------PDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTVR--ELVEALRQMGYTEAIEVIQA P_troglodytes_ENSPTRP00000028033 NGKPY--E---PEFTSDDLL---AQGDM--KQLAEDVKLQLYKLLEIPD------PDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTVR--ELVEALRQMGYTEAIEVIQA M_mulatta_ENSMMUP00000034946 NGKPY--E---PEFTSDDLL---AQGDM--KQLAEDVKLQLYKLLEIPD------PDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTVR--ELVEALRQMGYTEAIEVIQA P_pygmaeus_ENSPPYP00000016712 NGKPY--E---PEFISDDLL---AQGDM--KQLAEDVKLQLYKLLEIPD------PDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTVR--ELVEALRQMGYTEAIEVIQA C_familiaris_ENSCAFP00000015815 NGKPY--E---PEFTSDDLL---AQGDM--KQLTEDAKLQLYKLLEIPD------PDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTIK--ELVEALRQMGYTEAIEVIQA B_taurus_ENSBTAP00000027016 NGKPY--E---PEFTSDDLL---AQGDM--KQLTEDAKLQLYKLLEIPD------PDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTIK--ELVEALRQMGYTEAIDVIQA E_caballus_ENSECAP00000013133 NGKPY--E---PEFTSDDLL---AQGDM--KQLTEDAKLQLYKLLEIPD------PDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTIK--ELVDALRQMGYTEAVEVIQA M_musculus_ENSMUSP00000029812 NGKPY--E---PVFTSDDIL---PQGDM--KQLTEDTRLQLCKLLEIPD------PDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTIK--ELMEALQQMGYTEAIEVIQA R_norvegicus_ENSRNOP00000028944 NGKPY--E---PVFTSDDIL---PQGDI--KQLTEDTRLQLCKLLEIPD------PDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTIK--ELVEALRQMGYTEAIEVIQA M_domestica_ENSMODP00000025861 NGKPY--Q---SESTSSDLL---AQGDM--KQLDEEAKLQLYKLLEMPD------PDKNWSTLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTIR--ELVDALRQMGYTEAIEVIQK T_guttata_ENSTGUP00000003727 NGKPY--E---SAEVLEDLL---TQGHL--RELSENSKMQLYKLLELPD------PTKNWSTLAQKLGLGILNNAFRLSPSPSKTLLDNYEVSGGTVQ--ELITALRQMDHTEAIEIIQE G_gallus_ENSGALP00000020084 NGKPYI-A---AAAVSEDLL---SQGPL--RELNESSKQQLYKLLETPD------PSKNWSTLAEKLGLGILNNAFRLSPSPSKTLLDNYKISGGTVQ--ELIAALTQMDHTEAIEVIQK A_carolinensis_ENSACAP00000015967 NGKSS--K---TKVASDDLL---TPGNM--KELSDDVKSQLYKLLEVPD------LNKNWSMLAQKLGLGILNNAFRLSPSPSKTLLDNYEVSGGTVK--ELVDALREMDYPEAVEIIQ- X_tropicalis_ENSXETP00000046127 NGKPY--K---SEVAPEDSL---PQG---------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000005249 NGKEY--E---PKPSLREPKP-PPESDL--VSLGLQVKQQVCQALE---------REALWERLAQALGLGILNTAFRLSPVPARTLLDSYEVSGGTVS--ELLAALRSLGECQARSILEG G_aculeatus_ENSGACP00000022290 NGKEY--K---PKCPQRSIT--PAQGDL--ASLDVEVKQQVCCALE---------SEGCWEKLAHSLGLGILNTAFGLSPSPAKTLLQSYEVSGGTVR--ELLDGLRSVGDCRALNVLEE G_gorilla_ENSGGOP00000008878 XXXXX--X---XXXXXXXXX---XXXXX--XXXXXXXXXXXXXXXXXXX------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXX T_rubripes_ENSTRUP00000010369 NSRNSPKS---NCSSS------VAGAES--TSLDEDTVTQLMDVLSD--------TDVPWMRLAEKLGMKTLSQLYVDSKAPCLHLLQHYKLAGGPVQ--VLIEALQDLGLSEGVRLLR- G_aculeatus_ENSGACP00000001732 NPGLSPKS---SLHSR---------GAG--SRVDEDTLSRLVEVLSV--------GDVPWRKLAEKLGMMTLTHLYLDSPTPCHQLLQHYQLGGGPVQ--GLVEALQSLGLTEGVRLLRS A_carolinensis_ENSACAP00000014173 LLASLE-E---PEREQSAAPPVSRQGFI--LSLNSDTFQCLEQLLNRDC------HGADWVELAKRLGLCSLVETYRDTPSPSRRLLLSYELAGGSLK--GLLEALDTMGLTEGVKLLRR T_guttata_ENSTGUP00000007782 LCVL---Q---RSKQPSLRPP-SSEAPRLVLSLDSEALQGLEQLLNQDC------SGSDWIELAKRLGLCSLVETYKDTPSPSVSLLRSYELAGGSLG--GLLEALDSMGLHNAVRMLHK C_familiaris_ENSCAFP00000014918 LNAA---Q---DTMAPPLTPP-SPAGPD--LPLEDAVLQNLEHLLDGPG------AQGSWAELAERLGLRSLVDTYRKTASPSGSLLRSYKLAGGDLA--GLLCALSDMGLEEGVRLLRG M_musculus_ENSMUSP00000072859 LNAA---Q---NTTEPPLAPP-SPAGPG--LSLGDAALQNLEQLLDGPE------AQGSWAELAERLGLRSLVDTYRKTPSPSGSLLRSYKLAGGDLV--GLLEALSDMGLHEGVRLLKG B_taurus_ENSBTAP00000007904 LNAA---Q---DTMAPPLTPP-SPAGPE--IPLEDTVLQNLEHLLDGPG------AQGSWVELAERLGLRSLVDTYRRTASPSGSLLRSYQLAGGDWT--GLLNALSDMGLEEGVRLLKG M_mulatta_ENSMMUP00000003997 INAA---Q---NTMEPPLTPP-SPAGPG--LSLGDTALQNLEQLLDGPE------AQGSWAELAERLGLRSLVDTYRQTASPSGSLLRSYELAGGDMA--GLLEALSDMGLEEGVRLLRG E_caballus_ENSECAP00000017595 LNAA---Q---DTMAPPLTPP-SPAGPE--LPLEDTVLQNLEHLLDGPG------AQGSWAELAERLGLRSLVDTYRKTASPSGSLLRSYKLAGGDLA--GLLDALSDMGLEEGVRLLRG H_sapiens_ENSP00000358983 LNAA---Q---NTMEPPLTPP-SPAGPG--LSLGDTALQNLEQLLDGPE------AQGSWAELAERLGLRSLVDTYRQTTSPSGSLLRSYELAGGDLA--GLLEALSDMGLEEGVRLLRG T_nigroviridis_ENSTNIP00000016350 SSGTRP-S---PVHSG------SPGAES--ASLDEDTVSRLMDVLSD--------TDVPWMKLAEKLGMKTLTQLYVDTEAPCQHLLQHYKLAGGPVQ--VLIEALQDLGLSEGVRLLRT R_norvegicus_ENSRNOP00000026235 LNAA---Q---NTTEPPLAPP-SPAGPG--LSLGDAALQNLEQLLDGPE------AQGSWAELAERLGLRSLVDTYRKTPSPSGSLLRSYKLAGGDLV--GLLEALSDMGLHEGVRLLKA O_latipes_ENSORLP00000003676 QSGQSPTA---SRHSNKKIKA-NSGAEG--SGLNEDTLAQLVEVLSV--------SDIPWIKLAEKLGMMTLTHLYQDSPTPCHHLLQHYKLGGGAVD--DLVKALQSLGLTEGIRLLRN D_rerio_ENSDARP00000057671 DGRKGPKP---NSLSPKRTKI-STEEVN--QDLDNEVLSKLCGILIH--------DDVPWRELAEKLGMLTLTHLYQDSASPCQKLLESYQLSGGPVD--GLVEALQALGVREGVRLLRD D_rerio_ENSDARP00000056498 DGRKGPKP---NSLSPKRTKI-STEEVN--QDLDNEVLSKLCGILIH--------DDVPWRELAEKLGMLTLTHLYQDSASPCQKLLESYQV---------------------------- P_pygmaeus_ENSPPYP00000003023 LNAA---Q---NTMEPPLTPP-SPAGPG--LSLGDTALQNLEQLLDGPE------AQGSWAELAERLGLRSLVDTYRQTASPSGSLLRSYELAGGDLA--GLLEALSDMGLEEGVRLLRG X_tropicalis_ENSXETP00000000018 SKHT---P---GSASWKRREP----EPVNVLALETNTVQRLEKLLNEGQ------TGADWTELASRLRLQSLVETYRNTSSPTESLLRSYELAGGSLT--ELINTLQSMGLNKGVELLCK C_intestinalis_ENSCINP00000014252 NGVFMK-N---IKEELDNSNY-SDEEDL--ATLDPLIRLKLCKLLNLEK------SGSDWYALASRLSLDYIVPFIDTTENPTDLLLDNYMVIAG------LRSALMNIGRHDAVQLLNR P_troglodytes_ENSPTRP00000005089 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006827 LNAA---Q---NTTEPPLTPP-SPAXXX--XXXXXXXXXXXXXXXXXXX------XXXXXXXXXXXXXXXXXXXXXXXXXSPSGSLLRSYELAGGDLA--GLLEALSDMGLEEGVRLLRG O_cuniculus_ENSOCUP00000004978 LNAA---Q---SAVEPPLTPP-SPAGPG--LSLGDTALQNLEQLLDRLE------AQGSWAELAERLGLRSLVDTYRKTASLSGSLLRSYKLAGGDLA--GLLEALSDMGLEEGVRLLRG A_aegypti_AAEL007624-PA EDYSPPND-EPKLTPLENVPYNSTLEDGSVYLFDEVCLSHLCGLLN---------RKNLWREVGSLLDFNSFFMIWETSVNPAGMLLNYFEMQKVKLE--HLIDVLQALDQKEAIHYIDE M_mulatta_ENSMMUP00000037540 NQGVP--------VAPH-----TTEPML-----------------------------MEYPEAITRLVT-AQRPPDPAPAPLGAPGLPNGLLSG---D--EDFSSIADMDFSALLSQISS M_domestica_ENSMODP00000011996 NQGIP--------GTLEGPGP-SGEPML-----------------------------MEYPESITRLMTGSQRPPEPTPAPPGASGLANGLLGA---D--EVFPSMGDLDISAFLSQISS C_familiaris_ENSCAFP00000019655 NQGVS--------VAPH-----TAEPML-----------------------------MEYPEAITRLVTGSQRPPDPVPAPVGASGLPNGLLSG---D--EDFSSIADMDFSALLSQISS P_pygmaeus_ENSPPYP00000003533 NQGIP--------VAPH-----TTEPML-----------------------------MEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSG---D--EDFSSIADMDFSALLSQISS H_sapiens_ENSP00000384273 NQGIP--------VAPH-----TTEPML-----------------------------MEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSG---D--EDFSSIADMDFSALLSQISS R_norvegicus_ENSRNOP00000044552 NQGVA--------MSHS-----TAEPML-----------------------------MEYPEAITRLVTGSQRPPDPAPATLGTSGLPNG-LSG---D--EDFSSIADMDFSALLSQISS E_caballus_ENSECAP00000011798 NQGVS--------MAPH-----TAEPML-----------------------------MEYPEAITRLMSGSQRPPDPAPAPLG-PGLPNGLLSG---D--EDFSSISDMDFSALLSQISS B_taurus_ENSBTAP00000018453 NQGVP--------MGPH-----TAEPML-----------------------------MEYPEAITRLVTGSQRPPDPAPTPLGPPGLTNGLLSG---D--EDFSSIADVDFSALLSQISS P_troglodytes_ENSPTRP00000006707 NQGIP--------VAPH-----TTEPML-----------------------------MEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSG---D--EDFSSIADMDFSALLSQISS X_tropicalis_ENSXETP00000055326 SESQTSGT---LSAGLQEPG--TSQGTL-----------------------------MSYPDSIARLMT--NRPIEDDGEERIDSVLMNGVFDMQQGV--ESITSLLDLDLSSFMNIK-- M_musculus_ENSMUSP00000025867 NQGVS--------MSHS-----TAEPML-----------------------------MEYPEAITRLVTGSQRPPDPAPTPLGTSGLPNG-LSG---D--EDFSSIADMDFSALLSQISS C_familiaris_ENSCAFP00000006862 ---------------------------------------------------------NQYREVGFGGGL--------LSPGPEAT----------------------------------- B_taurus_ENSBTAP00000049624 ---------------------------------------------------------NQYREAGFGGGL--------LSPGPEAT----------------------------------- D_melanogaster_FBpp0088375 LSSGPRRQ---KDESSRDTEMDNNKLQL--LLKNKFIYDRLCSLLNQPLGHGSDPQDRKWMQLARQTHLKQFAFIWLGAED----LLDHVKRKGASVEFSTFARALQAVDPQAYALLVNP A_aegypti_AAEL006930-PA --------------------------------------------------------SNSFTKLTTNTTVNNMNK---------------------------------------------- A_gambiae_AGAP006747-PA EEHEPEAEPQRKATKRSDSGPDRTEPD---TLLDEQCLEELCRLLD---------AGSGWRELGSLLDFHSFFTVWEQAPSPARMLLGYFEMQQLHLD--RLIDMLRVLELRDPIRSIDE 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+= H_sapiens_ENSP00000226574 A---------SSPVKTTSQAHSLPLSPASTRQQIDE-----LRDSDSVCDSGVETSFRKLSFT--ESLTSGASLLTLNKMPHDY---GQEGPLEGKI-------------- P_troglodytes_ENSPTRP00000028033 A---------SSPVKTTSQAHSLPLSPASTRQQIDE-----LRDSDSVCDSGVETSFRKLSFT--ESLTSGASLLTLNKMPHDY---GQEGPLEGKI-------------- M_mulatta_ENSMMUP00000034946 A---------SSPVKTTSQAHSLPLSPASTRQQIDE-----LRDSDSVCDSGVETSFRKLSFT--ESLTSGGSLLTLNKMPHDY---GQEGPLEGKI-------------- P_pygmaeus_ENSPPYP00000016712 A---------SSPVKTTSQTHSLPLSPASTRQQIDE-----LQDSDSVCDSGVETSFRKLSFT--ESLTSGASLLTLNKMPHDY---GQEGPLEGKI-------------- C_familiaris_ENSCAFP00000015815 AFCAP-ETAAPSPGKGAPQTLSLPLSSASTRSPVDE-----VRD-DSICDSGVETSFRKLSFT--ESLTSGSSLLTLNKAPHEY---GQEGPIEGKI-------------- B_taurus_ENSBTAP00000027016 AFCTA-DT---SPAKTTSQAHSLPFAPASTRPQIDE-----LRD-DSICDSGVETSFRKLSFT--ESLTSGTSLLTLNKVPHDY---GQEGPIEGKI-------------- E_caballus_ENSECAP00000013133 AFCTS-GTAAPSPVTTTSQAPLLPLAPASTRQQIDE-----LRE-DSVCDSGVETSFRRLSFT--ESLTSGSSLLTLNKMPHDY---MQEGPIEGKI-------------- M_musculus_ENSMUSP00000029812 AFRTP-ATTASSPV-TTAQVHCLPLSSSSTRQHIDE-----LRDSDSVCDSGVETSFRKLSFT--ESLTGDSPLLSLNKMPHGY---GQEGPIEGKI-------------- R_norvegicus_ENSRNOP00000028944 AFRTP-ETTASSPV-TTAQAHLLPLSSSSTRQHIDE-----LRDNDSVCDSGVETSFRKLSFS--ESLTGDGPLLSLNKMPHNY---GQDGPIEGKI-------------- M_domestica_ENSMODP00000025861 AFSAS-QP--------TEQIYSLPPSPSCIRQQLGDICK--LQDNESVCDSGVETSFRKLSFT--ESLTSTGALITLNKMPCDY---GQETSIEGKV-------------- T_guttata_ENSTGUP00000003727 ALSIS-RRPPAPEDSTAKALPSSSPL-TFANGETGELFNSRFQDLESTCDSGVETSFRKLSFTSSDSLTSKSS-LTLGKMALGY------------G-------------- G_gallus_ENSGALP00000020084 ALSSS-QRQSHQEDNTIEAFPSLSPT-SFAKEETGELYNHKFQDPESTCDSGVETSFRKLSFTYSDSLNSKSS-ITLSKMTLGYRKAQCKAVIYLTR-------------- A_carolinensis_ENSACAP00000015967 --------------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000046127 --------------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000005249 ALFPSVDQGAGAANRRTGLCPPLPAGEQLKVE---------LGLDGEACDSGVELS------------------------------------------------------- G_aculeatus_ENSGACP00000022290 VLRHH-DEKEEALRR--------PADGSLVRDLKAD-----IRIDSGVCDSGVELS------------------------------------------------------- G_gorilla_ENSGGOP00000008878 X---------XXXXXXXXXXXXXXXXXXXXXXXXXE-----LRDSDSVCDSGVETSFRKLSFT--ESLTSGASLLTLNKMPHDY---GQEGPLEGKI-------------- T_rubripes_ENSTRUP00000010369 --------------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000001732 SELRD-DKHSTD-----------------------------ATVDSGFGSQPID--EEEEPPVANQ--------------------------------------------- A_carolinensis_ENSACAP00000014173 PESFP-KVQSTE-----------------------------LKEDSGYGSQSVE--EES---------------------------------------------------- T_guttata_ENSTGUP00000007782 TEALE-KLQSTE-----------------------------LKEDSAYGSESVE--EE----------------------------------------------------- C_familiaris_ENSCAFP00000014918 PEARD-KLPSTAE----------------------------VKEDSAYGSQSVE--QEAEKLGSPPEPPGGLCHGHPQPQVH----------------------------- M_musculus_ENSMUSP00000072859 PETRD-KLPST-E----------------------------VKEDSAYGSQSVE--QEAEKLCPPPEPPGGLCHGHPQPQVH----------------------------- B_taurus_ENSBTAP00000007904 PETQE-KLPST-E----------------------------VKEDSAYGSQSVE--QETEKLGPPPEPPGGLCHGRPQPQVH----------------------------- M_mulatta_ENSMMUP00000003997 PETRD-KLPST---------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000017595 PEARD-KLPST-E----------------------------AKEDSAYGSQSVE--QEAEKLGPPPEPPGGLCHGHPQPQVH----------------------------- H_sapiens_ENSP00000358983 PETRD-KLPSTAE----------------------------VKEDSAYGSQSVE--QEAEKLGPPPEPPGGLCHGHPQPQVH----------------------------- T_nigroviridis_ENSTNIP00000016350 TERQQ-EKHNTVQSE--------------------------ATVDSGFSSQPME--EEEQE-------------------------------------------------- R_norvegicus_ENSRNOP00000026235 PETRD-KLPST-E----------------------------VKEDSAYGSQSVE--QEAEKLCPPPEPPGGLCHGHPQPQVH----------------------------- O_latipes_ENSORLP00000003676 AELQE-DKHSTD-----------------------------ATVDSGFSSQPME--EEEQQ-------------------------------------------------- D_rerio_ENSDARP00000057671 SQPRE-DKQSSV--D--------------------------STEDSGFGSQSIG--EEMANPAVGNH-------------------------------------------- D_rerio_ENSDARP00000056498 --------------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000003023 PETRD-KLPSTAE----------------------------VKEDSAYGSQSVE--QEAEKLGPPPEPPGGLCHGHPQPQVH----------------------------- X_tropicalis_ENSXETP00000000018 SETYA-KHQSPAE----------------------------GKNDSAYESQSMEVDQSSAELSPTTEPAIGQ--------------------------------------- C_intestinalis_ENSCINP00000014252 AATTT-CVDKFDSNAT-------------------------EQCDSAFGSLPNQIDVI----------------------------------------------------- P_troglodytes_ENSPTRP00000005089 --------------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000006827 PETXD-KLPSTAE----------------------------VKEDSAYGSXSVE--QEAEKLGPPPEPPGGLCHGXPQPQVH----------------------------- O_cuniculus_ENSOCUP00000004978 PETRD-KLPST-E----------------------------VKEDSAYGSQSVE--QEAEKLGLPPEPSGGLCHGHPQPQTELPPSPRPGPSVQPHLCQILFNTPCLPLGK A_aegypti_AAEL007624-PA MICRQ-MK------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000037540 --------------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000011996 --------------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000019655 --------------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000003533 --------------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000384273 --------------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000044552 --------------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000011798 --------------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000018453 --------------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000006707 --------------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000055326 --------------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000025867 --------------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000006862 --------------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000049624 --------------------------------------------------------------------------------------------------------------- D_melanogaster_FBpp0088375 T-------------------------------------------------------------------------------------------------------------- A_aegypti_AAEL006930-PA --------------------------------------------------------------------------------------------------------------- A_gambiae_AGAP006747-PA MICRR-MK-------------------------------------------------------------------------------------------------------