>H_sapiens_ENSP00000247668 ------------------------------------------------MA---------- --AASVTPPGSLELLQP----------GFSKTLLGTKLEAKYLCSACRNVLRR------- ----------PFQAQ--------CGHRYCSFCLASIL-------SSGP---QNCA---AC VHEGI-YEEGISIL-ESSS--AFPDNAARREVESLPAVCPSDG--CTWKGTLKEYE---- ----------------------------------------------SCH--E-GRCPLM- LTECPA-------CKGLVRLGE----KER----HLEHECPERSLSCRHCRAPCCGADV-K --AHH-----------------------------------------------------E- VCPKFPLTCDGCGK--KKIPREKFQDHVK-TCGKC--RVPCRFHAIGCL---E--TVEGE KQQEHEVQWL---REHLAMLL--SSVLEAKPLLGDQ------------------------ ------------------------------SHAGSELL-------------------QRC ESLEKKTATFENI---VCVLNREVERV-AMTAEACSRQHRLD------------------ --------------QDKIEALSSK--------------------------VQQL-----E RSIGLKDLAMADLEQKVL--E--MEASTYD-GVFIWKISDFARKRQEAVAGRI--PAIFS PAFYTSRYGYKMCLRIYLNGDGTGR-GTHLSLFF-VVMKGPNDALLRWPFNQK---VTLM LLDQNNR-------EHVIDAFRPDV---TSSS-FQRP------------VND--MNIASG CPLFCPVSKMEA-KN-SYVRDDAIFIKAIVD-LTGL------------------------ --------------------- >P_troglodytes_ENSPTRP00000036949 ------------------------------------------------MA---------- --AASVTPPGSLELLQP----------GFSKTLLGTKLEAKYLCSACRNVLRR------- ----------PFQAQ--------CGHRYCSFCLASIL-------SSGP---QNCA---AC VHEGI-YEEGISIL-ESSS--AFPDNAARREVESLPAVCPSDG--CTWKGTLKEYE---- ----------------------------------------------SCH--E-GRCPLM- LTECPA-------CKGLVRLGE----KER----HLEHECPERSLSCRHCRAPCCGADV-K --AHH-----------------------------------------------------E- VCPKFPLTCDGCGK--KKIPREKFQDHVK-TCGKC--RVPCRFHAIGCL---E--TVEGE KQQEHEAQWL---REHLAMLL--SSVLEAKPLSGDQ------------------------ ------------------------------SHAGSELL-------------------QRC ESLEKKTATFENI---VCVLNREVERV-AMTAEACSRQHRLD------------------ --------------QDKIEALSSK--------------------------VQQL-----E RSIGLKDLAMADLEQKVL--E--MEASTYD-GVFIWKISDFARKRQEAVAGRT--PAIFS PAFYTSRYGYKMCLRIYLNGDGTGR-GTHLSLFF-VVMKGPNDALLRWPFNQK---VTLM LLDQNNR-------EHVIDAFRPDV---TSSS-FQRP------------VND--MNIASG CPLFCPVSKMEA-KN-SYVRDDAIFIKAIVD-LTGL------------------------ --------------------- >P_pygmaeus_ENSPPYP00000022191 ------------------------------------------------MA---------- --AASVTPPGSLELLQP----------GFSKTLLGTKLEAKYLCSACRNVLRR------- ----------PFQAQ--------CGHRYCSFCLASIL-------SSGP---QNCA---AC VHEGI-YEEGISIL-ESSS--AFPDNAARREVESLPAVCPSDG--CTWKGTLKEYE---- ----------------------------------------------SCH--E-GRCPLM- LTECPA-------CKGLVRLGE----KER----HLEHECPERSLSCRHCRAPCCGADV-K --AHH-----------------------------------------------------E- VCPKFPLTCDGCGK--KKIPREKFQDHVK-TCGKC--RVPCRFHAIGCL---E--TVEGE KQQEHEAQWL---REHLAMLL--SSVLEAKPLSGDQ------------------------ ------------------------------SHAGSELL-------------------QRC ESLENKTATFENI---VCVLNREVERV-AMTAEACSRQHRLD------------------ --------------QDKIEALSSK--------------------------VQQL-----E RSIGLKDLAMADLEQKVL--E--MEASTYD-GVFIWKISDFARKRQEAVAGRT--PAIFS PAFYTSRYGYKMCLRIYLNGDGTGR-GTHLSLFF-VVMKGPNDALLRWPFNQK---VTLM LLDQNNR-------EHVIDAFRPDV---TSSS-FQRP------------VND--MNIASG CPLFCPVSKMEA-KN-SYVRDDAIFIKAIVD-LTGL------------------------ --------------------- >M_mulatta_ENSMMUP00000015132 ------------------------------------------------MA---------- --AASVTPPGSLELLQP----------GFSKTLLGTKLEAKYLCSACGNVLRR------- ----------PFQAQ--------CGHRYCSFCLASIL-------SSGP---QNCA---AC VHEGI-YEEGISIL-ESSS--AFPDNAARREVESLPAVCPIDG--CTWKGTLKEYEVKMP VCGTVTEPAVGSRPRSPSGRDLVLHVLTGAEACLMSVEEETELLLRSCH--E-GRCPLM- LTECPA-------CKGLVRLGE----KER----HLEHECPERSLSCRHCRAPCCGADG-K --AHH-----------------------------------------------------E- VCPKFPLTCDGCGK--KKIPREKFQDHVK-TCGKC--RIPCRFHAIGCL---E--TVEGE KQQEHEAQWL---REHLAMLL--SSVLEAKPLLGDQ------------------------ ------------------------------SHAGSELL-------------------QRC ENLEKKTATFENI---VCVLNREVERV-AMTAEACSRQHRLD------------------ --------------QDKIEALSNK--------------------------VQQL-----E RSIGLKDLAMADLEQKVL--E--MEASTYD-GVFIWKISDFARKRQEAVAGRT--PAIFS PAFYTSRYGYKMCLRIYLNGDGTGR-GTHLSLFF-VVMKGPNDALLRWPFNQK---VTLM LLDQNNR-------EHVIDAFRPDV---TSSS-FQRP------------VND--MNIASG CPLFCPVSKMEA-KN-SYVRDDAIFIKAIVD-LTGL------------------------ --------------------- >E_caballus_ENSECAP00000011150 ------------------------------------------------MA---------- --AASVTPPGSLDLLQP----------GFSKTLLGTKLEDKYLCSACKNVLRR------- ----------PFQAQ--------CGHRYCSYCLTSIL-------SSGP---QNCA---AC VHEGI-YEEGISIL-ESSS--AFPDNAARREVESLPAVCPSDG--CTWKGTLKEYE---- ----------------------------------------------SCH--E-GHCPFM- LTECPA-------CKGLVRLGE----KEH----HLEHECPERSLSCRHCRAPCCWADM-K --AHH-----------------------------------------------------D- VCPKFPLTCDGCGK--KKISREKFQDHVR-TCGKC--RVPCRFHAVGCP---E--MVESE KQQEHEAKWL---QEHLAMLLDSSSFLGQSQVGNPG------------------------ ----------------------------AEVSKAAELL-------------------QRC EALERKTATFENI---VCVLNREVERV-AMTAEACGRQHRLD------------------ --------------QDRIEALSNK--------------------------VQQL-----E RSIGLKDLAMADLEQKVH--E--MEASTFD-GVFIWKISDFTRKRQEAVAGRT--PAIFS PAFYTSRYGYKMCLRIYLNGDGTGR-GTHVSLFF-VVMKGPNDALLRWPFNQK---VTLM LLDQNNR-------EHVIDAFRPDV---TSSS-FQRP------------VSD--MNIASG CPLFCPVSKMEA-KN-SYVRDDAIFIKAIVD-LTGL------------------------ --------------------- >C_familiaris_ENSCAFP00000028895 ------------------------------------------------MA---------- --AASVTPPGSLDLLQP----------GFSKTLLGTKPEDKYLCSACRNVLRR------- ----------PFQAQ--------CGHRYCSYCLSSIL-------SSGP---QNCA---AC VHEGI-YEEGISIL-ESSS--AFPDNAARREVESLPAVCPNNG--CTWKGTLKEYE---- ----------------------------------------------SCH--E-GHCPFM- LTECPA-------CKGLVRLGE----KEH----HSEHECPERSLSCRHCRAPCCWADL-K --AHH-----------------------------------------------------E- VCPKFPLTCDGCGK--KKISREKFQDHVR-ACGKC--RVPCRFHVVGCP---E--MVESE KQQQHEAHWL---REHLAMLL--GSLLEAKHLSGAG------------------------ -----------------------------GPFLGLKLQ-------------------QRC EALERKTATFENI---VCVLNREVERV-AMTAEACGRQHQLD------------------ --------------QDRIEALSNK--------------------------VQQL-----E RTIGLKDLAMAELEQKVH--E--MEASTFD-GVFIWKISDFARKRQEAVAGRT--PAIFS PAFYTSRYGYKMCLRIYLNGDGTGR-GTHLSLFF-VVMKGPNDALLRWPFNQK---VTLM LLDQNNR-------EHVIDAFRPDV---TSSS-FQRP------------VSD--MNIASG CPLFCPVSKMEA-KN-SYVRDDAIFIKAIVD-LTGL------------------------ --------------------- >M_musculus_ENSMUSP00000109872 ------------------------------------------------MA---------- --AASVTSPGSLELLQP----------GFSKTLLGTRLEAKYLCSACKNILRR------- ----------PFQAQ--------CGHRYCSFCLTSILRCASILSSSGP---QNCA---AC VYEGL-YEEGISIL-ESSS--AFPDNAARREVESLPAVCPNDG--CTWKGTLKEYE---- ----------------------------------------------SCH--E-GLCPFL- LTECPA-------CKGLVRLSE----KEH----HTEQECPKRSLSCQHCRAPCSHVDL-E --VHY-----------------------------------------------------E- VCPKFPLTCDGCGK--KKIPRETFQDHVR-ACSKC--RVLCRFHTVGCS---E--MVETE NLQDHELQRL---REHLALLL--SSFLEAQASPGTL------------------------ ------------------------------NQVGPELL-------------------QRC QILEQKIATFENI---VCVLNREVERV-AVTAEACSRQHRLD------------------ --------------QDKIEALSNK--------------------------VQQL-----E RSIGLKDLAMADLEQKVS--E--LEVSTYD-GVFIWKISDFTRKRQEAVAGRT--PAIFS PAFYTSRYGYKMCLRVYLNGDGTGR-GTHLSLFF-VVMKGPNDALLQWPFNQK---VTLM LLDHNNR-------EHVIDAFRPDV---TSSS-FQRP------------VSD--MNIASG CPLFCPVSKMEA-KN-SYVRDDAIFIKAIVD-LTGL------------------------ --------------------- >B_taurus_ENSBTAP00000013869 ------------------------------------------------MA---------- --AASVTPPGSLDLLQP----------GFSKTLLGTKLEDKYLCSACKNVLRR------- ----------PFQAQ--------CGHRYCSFCLSSIL-------SSGP---QSCA---AC VHEGI-YEEGVSIL-ESSS--AFPDNAARREVESLPAVCPSEG--CSWKGTLKDYE---- ----------------------------------------------SCH--E-GQCPFM- LTECPA-------CKGLVRLGE----KEH----HLEHQCPERSLSCRHCRAPCSPADM-K --AHH-----------------------------------------------------Q- ICPKFPLTCDGCGK--KKIAREKFQDHVR-ACGRC--RVPCRFHAVGCP---E--MVESE QQPEHEAQRL---QEHLALLL--GVLLEAGRPPGDS------------------------ ----------------------------RLLLRVAELL-------------------QRC EALERKTATFENI---VCVLNREVERV-AVTAEACGRQHRLD------------------ --------------QDRIEALSNK--------------------------VQQL-----E RSIGLKDLAMADLEQKVL--E--MEASTFD-GVFIWKISDFSRKRQEAVAGRT--PAIFS PAFYTSRYGYKMCLRAYLNGDGTGR-GTHLSLFF-VLMRGPHDALLRWPFNQK---VTLM LLDQNNR-------EHVIDAFRPDV---TSSS-FQRP------------VGD--MNIASG CPLFCPVSKMEA-KN-SYVRDDAIFIKAIVD-LTGL------------------------ --------------------- >M_domestica_ENSMODP00000021625 ------------------------------------------------MA---------- --TANSTPPGSLDLLQP----------GFSKDILGTKLEDKYLCSACKNILRR------- ----------PFQAQ--------CGHRYCSYCLTSII-------STGP---QNCA---AC IQEGI-YEEGISIL-ESSS--AFPDNAARREVESLPAVCVNDG--CTWKGTIKEYE---- ----------------------------------------------SCH--E-GHCSFM- LIECPA-------CKWMIKLGE----KEH----HSERECPKRSLNCRYCKALFYYPDI-K --AHD-----------------------------------------------------E- ICPKFPLTCEGCGK--KKILREKFQDHVK-ACGKC--KGPCKFHVVGCT---E--MVENE KQQDHENQKV---AEHLCMLL--NFVLEARHFHGDI------------------------ -----------------------------EMSKSTELL-------------------ERC ETLERKTVTFENI---VCVLNREVERV-SMTAEACSRQHRLD------------------ --------------QEKIETLSSK--------------------------VQQL-----E RSIGLKDLAMADMEQKIL--E--MEASTYD-GIFIWKITDFARKRQEAMAGRS--PAIFS PAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFF-VVMKGPNDALLRWPFNQK---VTLM LLDQNNR-------EHVIDAFRPDV---TSSS-FQRP------------VSD--MNIASG CPLFCPVSKMES-KN-SYVRDDAIFIKAIVD-LTGL------------------------ --------------------- >G_gallus_ENSGALP00000014649 ------------------------------------------------MA---------- --AANSTPPGSLDLSQP----------GFAKEILGTKLEVKYLCSDCRNILRR------- ----------PFQAQ--------CGHRYCSYCLKKII-------SSGP---QKCA---SC IQEGI-YEEGISIL-ETSS--AFPDNAARREVESLPAVCINEG--CTWKGTIKEYE---- ----------------------------------------------SCH--E-GNCPFL- LIECQA-------CRGVIPLNE----KER----HSERECPERTLNCKYCKSLFYFPDI-K --AHD-----------------------------------------------------E- VCPKFPLTCDGCGK--KKIPREKFQDHVK-NCGKC--KVPCRFKVVGCA---E--MVENE KLPEHESKCL---AEHLYMLL--SFVLSLKSGSGDLKHLPAIPSSQSSSPLLAA------ ----------------------NSLCPESELFKSLELL-------------------GRC DALEKKTVTFENI---VCVLNREVERV-SLTAEAYSRQHRLD------------------ --------------QEQIETLSNK--------------------------VRQL-----E RSIGLKDLAMAEMEEKIR--N--MEASTYD-GVFIWKITEFARKRQEAITGRS--PAIFS PAFYTSKYGYKMCLRVYLNGDGTGR-GTHLSLFF-VVMKGPNDALLRWPFNQK---VTLM LLDQNNR-------EHIIDAFRPDV---TSSS-FQRP------------VTE--MNIASG CPLFCPVSVMEA-KN-SYVRDDAIFIKAIVD-LSGL------------------------ --------------------- >R_norvegicus_ENSRNOP00000058607 ------------------------------------------------MA---------- --AASVTSPGSLELLQP----------GFSKTLLGTRLEAKYLCSACRNILRR------- ----------PFQAQ--------CGHRYCSFCLTSILRSQSAHSSSGP---QNCA---AC VHEGL-YEEGISIL-ESSS--AFPDNAARREVESLPAVCPNDG--CTWKGTLKEYE---- ----------------------------------------------SCH--E-GLCPFL- LTECPA-------CKGLVRLSE----KKH----HTEQECPKRSLSCQHCRAPCSHADL-E --LHY-----------------------------------------------------E- VCPKFPLTCDGCG---KKISQEKLQDHVR-TCSKC--RVLCRFHAIGCS---E--LVETE DLQDHELQRL---REHLALLL--SSFLESQASQNQV------------------------ ---------------------------------GPELL-------------------QRC QILEQKIATFENI---VCVLNREVERV-AVTAEACSRQHRLD------------------ --------------QDKIEALSNK--------------------------VQQL-----E RSIGLKDLAMADLEQKVS--E--LEVSTYD-GVFIWKISDFARKRQEAIAGRT--PAIFS PGAVCVLRMLLMLLNVYLQGRGTGR-QTHLSQLS-VCARAYWAVVLQWLLTEQ---VTLM LLDHNNR-------EHVIDAFRPDV---TSSS-FQRP------------VSD--MNIASG CPLFCPVSKIEA-KN-SYVRDDAIFIKAIVD-LTGL------------------------ --------------------- >G_gorilla_ENSGGOP00000006994 ------------------------------------------------MA---------- --AASVTPPGSLELLQP----------GFSKTLLGTKLEAKYLCSACRNVLRR------- ----------PFQAQ--------CGHRYCSFCLASIL-------SSGP---QNCA---AC VHEGI-YEEGISIL-ESSS--XXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXX---- ----------------------------------------------SCH--E-GRCPLM- LTECPA-------CKGLVRLGE----KER----HLEHECPERSLSCRHCRAPCCGADV-K --AHH-----------------------------------------------------E- VCPKFPLTCDGCGK--KKIPREKFQDXVK-TCGKC--RVPCRFHAVGCL---E--TVEGE KQQEHEAQWL---REHLAMLL--SSVLEAKPLSGDQ------------------------ ------------------------------SHAGSELL-------------------QRC ESLEKKTATFENI---VCVLNREVERV-AMTAEACSRQHRLD------------------ --------------QDKIEALSSK--------------------------VQQL-----E RSIGLKDLAMADLEQKVL--E--MEASTYD-GVFIWKISDFARKRQEAVAGRT--PAIFS PXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXX-XXXXXXXXXXXXXXXXXX---VTLM LLDQNNR-------EHVIDAFRPXV---TSSS-FQRP------------VND--MNIASG CPLFCPVSKMEA-KN-SYVRDDAIFIKAIVD-LTGL------------------------ --------------------- >T_nigroviridis_ENSTNIP00000016461 ------------------------------------------------MA---------- --AQEPSPPSSMESNKP----------GFPKKILGNKLEDKHLCNCCHNILRR------- ----------PFQAQ--------CGHRFCSYCFTRTV-------SNGP---QKCS---AC IKEDI-FEDPTSIL-KQGC--AFPDNAVRREVEHLPAVCINEN--CTWKGTIKEYE---- ----------------------------------------------LSH--E-GKCEFM- IISCPS-------CKEHIRFNE----QER----HNERECPERTLNCKYCKEPFHFKNI-K --AHD-----------------------------------------------------E- ICPKYPMICEGCAK--KKIPREKYVDHIK-FCSKF--RTPCRFHVVGCD---M--SVEKE KIHDHERAFA---YEHLNLLL--HYIMGMKASRAG------------------------- -----------------------------EKTKVAELG-------------------RRC TELEVKANTFENV---VCVLNREVERF-ATTMEASNRQHKLD------------------ --------------QDKIEALSNK--------------------------VRQL-----E RTVGLKDLTVAEMEGRLR--E--MSATTFD-GVFVWRISDFAKKRQDAIAGRA--PAMFS PAFYTSKYGYKMCLRIYLNGDGTGR-GSHLSLFF-VVMRGQSDALLKWPFNQK---VTLM LLDQSNR-------EHIIDAFRPDV---TSSS-FQRP------------VSE--MNIASG CPLFCPLSKLDG-KN-SYIRDDTIFIKAIVD-LTGL------------------------ --------------------- >T_guttata_ENSTGUP00000002510 ------------------------------------------------MA---------- --AANSSPPGSLDLNQP----------GFAKEILGTKLEVKYLCSDCKNILRR------- ----------PFQAQ--------CGHRYCSYCLKKII-------SAGP---QKCA---SC IQEGI-YEEGISIL-ETSS--AFPDNAARREVESLPAVCINSG--CNWKGTIKEYE---- ----------------------------------------------VQA--K-ARLGTS- ASFFPL-------C-----LGK----AQRVVCAHVGESCQIPGLYCQLEKFP-NVVHM-V --LHC-----------------------------------------------------E- ETPHCECSWRNCEGIWKKHPGAAFRDHVK-TCGRS--KVPCRFEAVGCA---E--VVENE KLPEHERKCL---AEHLYMLM--SSVLSLKTGAGDL------------------------ --------------------------------KPLPLL-------------------GRC EALERKTVTFENI---VCVLNREVERV-SLTAEAYSRQHRLD------------------ --------------QEKIETLSNK--------------------------VRQL-----E RSIGLKDLAMAEMEEKIR--N--MEASTYD-GVFIWKITEFARKRQEAITGRS--PAIFS PAFYTSKYGYKMCLRVYLNGDGTGR-GTHLSLFF-VVMKGPNDALLRWPFNQK---VTLM LLDQNNR-------EHIIDAFRPDV---TSSS-FQRP------------VTE--MNIASG CPLFCPVSVMEA-KN-SYVRDDAIFIKAIVD-LTGL------------------------ --------------------- >G_aculeatus_ENSGACP00000006974 ------------------------------------------------MA---------- --AQEQSPPSSLEGNKP----------GFPKKILANSLEDKHLCNSCQKVLRR------- ----------PLQAQ--------CGHRFCSFCFNKIV-------SSGP---QKCS---AC IKEDL-FEDPTSIL-KQGG--AFPDNAARREVEALAAVCPNEE--CTWTGTIKEFE---- ----------------------------------------------ASH--E-DNCDFM- IIMCPS-------CKELMRANE----QER----HNERECPERTLNCRYCKEPFLLKNI-K --AHD-----------------------------------------------------E- ICPKYPMICEGCAK--KKIPREKYVDHIK-FCSKC--KAPCRFHVVGCDASVM--EVENE KLHDHERQCS---YEHLNLLL--HFIMGIK------------------------------ LQLQ------------------------SEKAKVAELS-------------------RRC QELELKVGTFENI---ACVLNREMERS-CSTMEAYNRQHRLD------------------ --------------QDKIEILNNK--------------------------VRQL-----E RTVSLRDLSIVEMEGKMR--D--MSAATYD-GIFVWKISDFTKKRQDAVAGRA--PAMFS PAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFF-VVMRGHSDALLKWPFNQK---VTLM LLDQNSR-------EHIIDAFRPDV---SSSS-FQRP------------VSD--MNIASG CPLFCPLPKLDS-KN-SYIRDDTIFIKAIVD-LTGL------------------------ --------------------- >O_latipes_ENSORLP00000003220 ------------------------------------------------MA---------- --ALEPSPPSSMESNKP----------GFPKKILGNKLEDKHLCNCCHNILRR------- ----------PIQAQ--------CGHRFCSYCFNRTV-------SNGP---QKCN---AC IKEEI-FEEPTSIL-KQGC--AFPDNAVRREVEGLSADCINEN--CPWKGTIKEYE---- ----------------------------------------------LDH--E-GKCEFM- IIPCPS-------CKERIRFSE----QER----HSERECPERTLNCKYCKEPFHFKNI-K --AHD-----------------------------------------------------E- ICPKYPMICEGCAK--KKIPREKYVDHIK-FCSKF--RTPCRFHVVGCD---M--SVEKE KIHDHERAFA---YEHLNLLL--HYIMGMKVSMEGLQPQGLETAGHKLVELQKSL-RDLE ARVS--QLSTTSSGP---------------PVQGAAAS-------------------SSS SRLEVKSGTFENV---VCVLNREVERF-TTTMEASNRQHKLD------------------ --------------QDKIEALSNK--------------------------VRQL-----E RTVGLKDLTVAEMEGRLR--E--MAATTFD-GVFIWRISDFAKKRQDAVAGRA--PAMFS PAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFF-VVMRGLSDALLKWPFNQK---VTLM LLDQSNR-------EHIIDAFRPDV---TSSS-FQRP------------VSE--MNIASG CPLFCPLSKLDA-KN-SYIRDDTIFIKAIVD-LTGL------------------------ --------------------- >T_rubripes_ENSTRUP00000011363 ------------------------------------------------------------ --SQEPSPPSSLEGNKP----------GFPKKILANNLENKHLCKSCQKVLRR------- ----------PLQAQ--------CGHRFCSFCFHKIV-------SAGP---QTCS---AC ISEDL-FEEPASIL-KLGG--AFPDNAARREVEALAAVCPNEG--CIWTGTIKEFE---- ----------------------------------------------ARH--E-DSCDFM- IILCPS-------CKELMRVNE----QER----HNERECPERTLNCKYCKDPFQLKNI-K --AHD-----------------------------------------------------E- ICPKYPMICEGCSK--KKIPREKYVDHIK-YCSKF--KSPCRFHVVGCN---T--SVEKE KIHDHERQCS---YEHLNLLL--HFIMGIKISLESLPPQSLDVASHKLLELHQSL-RDLE LKLQ------------------------SEKTKVAELS-------------------RRC QDLELKVRTFENI---VCVLNREVERS-CTTMEAYNRQHRLD------------------ --------------QDKIEILNNK--------------------------VRQL-----E RTVSLRDLSIVEIDEKMR--E--LSAATYD-GVFVWKISDFTKKRQDAVAGRA--PAMFS SAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFF-VVMRGHSDALLKWPFNQK---VTLM LLDQNNR-------EHIIDAFRPDI---SSSS-FQRP------------VSD--MNIASG CPLFCPLPKLDC-KN-SYIRDDTIFIKVIVD-LTGL------------------------ --------------------- >O_latipes_ENSORLP00000020860 ------------------------------------------------------------ --QQEPSPPSSLEGSKP----------GFPRKILANCLEDKHLCNSCEKILRR------- ----------PLQAQ--------CGHRFCCFCFNRTV-------SSGP---QKCS---AC IKEDL-FEEPTSIL-KQGG--AFHDNAARREVEALAAVCPNEG--CTWTGTVKEYE---- ----------------------------------------------ASH--E-GSCDFT- IIMCPS-------CKELMRANE----QER----HNERECPERTLNCKYCKEPFLLKNI-K --AHD-----------------------------------------------------E- ICPKYPMMCEGCAK--KKIPREKYVDHIK-FCSKF--KAPCRFHVVGCD---T--SVEKE KIHDHERQCS---YEHLNLLL--HFIMGIKGVCAATLATS-------FTPLHSAMGAALE LQLQ------------------------SEKTKVAELS-------------------RRC QELELKVSTFENI---VCILNRELERS-CATMEAYNRQHRLD------------------ --------------QDKIEILSNK--------------------------VRQL-----E RTVSLRDLSIVEMEGKMK--D--MSAATYD-GIFIWKISDFTKKRQDAMAGRA--PAMFS PAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFF-VVMRGHSDALLKWPFNQK---VTLM LLDQNNR-------EHIIDAFRPDI---SSSS-FQRP------------VSD--MNIASG CPLFCPLSKLDS-KN-SYIRDETIFIKAIVD-LSGL------------------------ --------------------- >T_rubripes_ENSTRUP00000015632 ---------------------------------------------TDAMA---------- --TQEPSPPSSMESNKP----------GFPKKILGNKLEDKHLCNCCHNILRR------- ----------PFQAQ--------CGHRFCSYCFNRTV-------SNGP---QKCS---AC IKRIL-WFQ------------AFPDNAVRREVEHLPAACINEN--CTWKGTIKEYE---- ----------------------------------------------LNH--E-GKCEFM- IISCPS-------CKEHIRFNE----QER----HNERECPERTLNCKYCKEPFHFKNI-K --AHD-----------------------------------------------------E- ICPKYPMICEGCAK--KKIPREKYVDHIK-FCSKF--RTPCRFHVVGCD---M--SVEKE KIHDHERAYA---YEHLNLLL--HYIMGMKVSMEGLQPQGLEVAGQKLVELQQSL-RELE LSVS----TSFTPLPSSVG-AALELQLHSEKTKVAELG-------------------RRC TELEVKANTFENV---VCVLNREVERF-ATTMEASNRQHKLD------------------ --------------QDKIEALSNK--------------------------VRQL-----E RTVGLKDLTVAEMEGRLR--E--MSATTFD-GVFVWRISDFAKKRQDAIAGRA--PAMFS PAFYTSKYGYKMCLRIYLNGDGTGR-GSHLSLFF-VVMRGQSDALLKWPFNQK---VTLM LLDQSNR-------EHIIDAFRPDV---TSSS-FQRP------------VSE--MNIASG CPLFCPLSKLDG-KN-SYIRDDTIFIKAIVD-LTGL------------------------ --------------------- >T_nigroviridis_ENSTNIP00000013509 ------------------------------------------------MA---------- --SQEPSPPSSLEGNKP----------GFPRKILANNLESKHLCKSCQKVLRR------- ----------PLQAQ--------CGHRFCCFCFRKIV-------SAGP---QTCR---AC ISEDL-FEEPASIL-KSGG--AFPDNAARREVEALAAVCPNEG--CTWTGTIKEFE---- ----------------------------------------------ARH--E-DSCDFM- IILCPS-------CKELMRANE----QER----HNERECPERTLNCKYCKEAFQLKSI-K --AHD-----------------------------------------------------E- ICPKYPMMCEGCSR--RKIPREKYVDHIK-YCSKF--KSPCRFHVVGCN---I--KVEKE KIHEHERQCS---YEHLNLLL--HFIMGIKSS---------------------------- ---R------------------------AKKTKVAELS-------------------RRC QELEVKVSTLENI---ACVLNREVERS-CTTMDAYNRQHRLD------------------ --------------QDKIEILNNK--------------------------VRQL-----E RTVSLRDLSIVEMDEKMR--E--LSAATYD-GVFVWKIADFTKKRQDAVAGRA--PAMFS PAFYTSKYGYKMC-RIYLNGDGTGR-GSHLSLFF-VVMRGHSDALLKWPFNQK---VTLM LLDQNNR-------EHIIDAFRPDV---SSSS-FQRP------------VSD--MNIASG CPLFCPLSKLDC-KN-SYIRDDTIFIKVIVD-LSGL------------------------ --------------------- >D_rerio_ENSDARP00000043465 ------------------------------------------------------------ --AQEPSPPSSLEGNKP----------GFPKKILANKLEDKHLCNICLKILRR------- ----------PFQAQ--------CGHRFCSYCFNKAV-------SKDK---KVCT---TV V----------IMK-KKKK--AFPDNAAKREVEALEAVCINEE--CSWTGTIKEYE---- ----------------------------------------------ANH--E-GKCDFR- ILPCPS-------CKELLRANE----LER----HNERECPERTLNCKYCKEPFHFKNI-K --AHD-----------------------------------------------------E- ICPKYPMICEGCAK--KKIPREKYVDHIK-LCTKF--RTPCRFHVVGCD---M--TVEKE KIHDHEQACS---YEHLNLLL--HFIMGIKVNLESLQPQSLELASHKIHELHQSL-RELE L--------------------------------------------------------KMG QELELKVNTFENI---VCVLNREMERS-ATTMEAYNRQHRLD------------------ --------------QDKIEILNNKIESNQGIKCEADNSCFSPRNYWMFVQVRQL-----E RTVGLRDLSIVEMEAKMR--E--MSAATYD-GVFVWKISDFSKKRQDAVAGRA--PAMFS PAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFF-VVMRGHSDALLKWPFNQK---VTLM LLDQNNR-------EHIIDAFRPDI---SSSS-FQRP------------VSD--MNIASG CPLFCPLSKLDS-KN-SYIRDDTIFIKAIVD-LTGL------------------------ --------------------- >D_rerio_ENSDARP00000069217 -------------------------------------------------MISAAGTLCKW KDMERPSLPSSLDSTLP----------GISREVLSVSMEPKYQCQQCKDILRK------- ----------PFQAQ--------CGHRFCVFCFKQLT-------SSGP---IPCE---AC RAEGI-FEEETSVL-NIAV--AFPDNAARREIDSLPAKCPNEG--CSWSGTLKDFE---- ----------------------------------------------NQH--E-GRCAFE- RVKCEA-------CQVLILLSE----KDR----HNERECEARTLNCKYCKVTFNFKEI-K --AHD-----------------------------------------------------E- ICQKFPMQCKDCGK--KKIPREKFQEHTK-SCAKS--KSACQFREIGCR---A--VVDNC KQQEHEQTSI---MEHLRLML--ALLSSMRLR---AEGAG-EWQEDVGLGLYRGPEDA-- ----------------------------PPAGAHNVGR-------------------GGG PGVQKKVTTLENI---VCVLNKEVERS-ALTMEAISRQHRLD------------------ --------------QEKIENLSNK--------------------------VRQL-----E RTLTTRDLQLAESEQSLR--E--LQFCTYD-GVFIWKIAEFSRRRQDAVAGRA--PAMFS PAFYSSKYGYKMCLRLYLNGDGTGR-GSHLSLFF-VVMKGKYDALLKWPFSQK---VTLM LLDQNNR-------EHIIDAFRPDV---SSTS-FQRP------------ISE--MNIASG CPLFCPLAKLAG-KS-SYLRDDTIFIKAIVD-LTGL------------------------ --------------------- >X_tropicalis_ENSXETP00000008559 ------------------------------------------------AA---------- --AVSGSPQGSLDLNQP----------GFKKEILGTKLEVKYLCSDCKNLLRR------- ----------PLQAQ--------CGHRYCSHCLNKII-------STGP---QKCS---AC IQEGI-WHQTVCIV-SDWG--GQPGNV--RGVGGGSSVILGGGMYCVLNPTHQSGR---- ----------------------------------------------YCY--S-LGTCTA- LTHCVL-------CPGYPWNYS----GDL----HSERECPERKLNCRYCKLSFYFPDI-K --AHD-----------------------------------------------------E- ICPKFPMTCEGCGR--KKIPREKFPDHVK-ICGRC--KVPCRYAAVGCT---E--MVEND KCLEHENKSL---AEHLAKGS--PAPPANAPP---------------------------- ----------------------------NNSAKVAEML-------------------LKF DTLDKKNTTFENI---VSVLNREVERS-SHAAEELARQLRAA------------------ --------------QEKVEALTTK--------------------------VRQL-----E RTLGQKELIVAELETRMQ--E--SELSTYD-GVFIWKISEFGKKRQDAINGRC--PAMFS PPFYTNKYGYKMCLRIYLNGDGTGR-NTHLSLFF-VVMKGNNDALLRWPFNQK---VTLM LLDQNNR-------EHVIDAFRPDV---SSSS-FQRP------------ISE--MNIASG CPLFCQVSKLEG-KN-SYVRDDTIFVKVIVD-LTGL------------------------ --------------------- >G_aculeatus_ENSGACP00000020860 ------------------------------------------------MA---------- --TQEPSPPSSMESNKP----------GFPKKILGNQLEDKHLCNCCHNILRR------- ----------PFQAQ--------CGHRFCSYCFNRTV-------SNGP---QKCS---AC IKEDL-FEDPTSIL-KPGC--AFPDNAVRREVENLSAVCIHEH--CSWKGSIKDYE---- ----------------------------------------------LTH--E-GKCEFM- IIPCPS-------CKERIRFNE----QER----HNERECPERTLNCKYCKEPFHFKNI-K --AHD-----------------------------------------------------E- ICPKYPMICEGCAK--KKIPREKYVDHIK-FCSKF--RTPCRFHVVGCD---M--SVEKE KIHDHERAFA---YEHLNLLL--HYIMGMKVSMEGLQPQGLELAGHKLLELQQAL-RELE ARVS--QLSTTSSGP---------------PVQ--------------------------C TELEVKAGTFENV---VCVLNREVERF-ATAMEASNRQHKLD------------------ --------------QDKIEALSNK--------------------------VRQL-----E RTVGLKDLTVAEMEGRLR--E--MSATTFD-GVFVWRISDFAKKRQDAIAGRA--PAMFS PAFYTSKYGYKMCLRIYLNGDGTGR-GSHLSLFF-VVMRGLSDALLKWPFNQK---VTLM LLDQSNR-------EHIIDAFRPDV---TSSS-FQRP------------LER-------- -P--CSLC---------------------------F------------------------ --------------------- >T_nigroviridis_ENSTNIP00000011878 ------------------------------------------------------------ --MARISLDCS--PSLP----------GIPLSVLSVPMENKYKCQQCLQVLRK------- ----------PVQAQ--------CGHRFCVHCFRELT-------SSGP---KPCE---AC RQEEI-YEEPTSIL-NSNE--VFPDNAAGREIASLPARCLNQD--CSWTGSIKQYE---- ----------------------------------------------AQH--E-GRCEFE- QIKCDA-------CQAFVLRAE----KDR----HNERECEARTLNCKYCKFTFHFKDI-K --AHD-----------------------------------------------------E- ICSKFPLQCKDCGK--KKIPREKFNEHIK-SCAKS--KSACPFSEVGCK---S--VVENG KLSEHENSST---MEHMRLLL--PIVLSLTQARAEVSDSG-EWQEDSVLGLYRAPEEG-- ----------------------------VHVGAGAAAS-------------------VH- VNLEKKVTALERI---VCVLNREVERS-TAMLEAFAHQHALD------------------ --------------QEKIENLSTK--------------------------LGQL-----E RVIAMRDLQLSETEQMVR--E--LQSCTYD-GIFVWKISEFSRRRQEAVAGRT--PAMFS PAFYSSKYGYKMCLRLYLNGDGTGR-GTHLSLFF-VVMKGKCDALLKWPFSQK---VTLM LLDQNNR-------EHIIDAFRPDV---TSSS-FQRP------------ISE--MNIASG CPLFCPLAKLAG-KS-PYLKDDTIFIKAIVD-LTGL------------------------ --------------------- >T_rubripes_ENSTRUP00000047803 ------------------------------------------------------------ --MARISMDCS--SSLP----------GIPLSVLSVPMENKYKCQQCLQVLRK------- ----------PVQAQ--------CGHRFCIHCFKELT-------SSGP---KPCE---AC RQEEI-YEEPISVL-NSNE--VFPDNAAGREIASLPARCLNQG--CSWTGSIKQYE---- ----------------------------------------------AQH--E-GRCELE- QIKCDA-------CQASVLRAE----IDR----HNERECEARTLNCKYCKLTFHFKDI-K --AHD-----------------------------------------------------D- ICLKFPLPCKDCGK--KKIPREKFNEHIR-SCAKS--KSACPFSEVGCK---S--VVDNG KLREHEHSST---VEHLHLLL--PMVLSLTRTRAEVSESG-EWQEDSGLGLYRAPEEG-- ----------------------------VNVGAGAAAS-------------------VHA VDLEKKVTALENI---ICVLNREVERS-ALKVEAFAHQHCLD------------------ --------------QEKIENLVSK--------------------------VGQL-----E RAIAMRDLQLSETEQMVR--E--LQSCTYD-GIFVWKISEFSRRRQEAVAVRM--PTMFS PAFYSSKYGYKMCLRLYLNGDGTGR-GTHLSLFF-VVMRGKCDALLKWPFSQK---VTLM LLDQNNR-------EHIIDAFRPDV---TSSS-FQRP------------ISE--MNIASG CPLFCPLAKLAG-KS-PYLKDDTIFIKAIVD-LTGL------------------------ --------------------- >O_latipes_ENSORLP00000008989 ------------------------------------------------------------ --MARISWDSL--SSLP----------GIPLSVLSVPMEDKYKCQQCLQVLRK------- ----------PVQAQ--------CGHRFCVHCFRQLT-------SSGP---KPCQ---AC RKEEI-YEEPMSIL-NSSE--AFPDNAAGREIASLPARCLNQG--CDWTGSIKEYE---- ----------------------------------------------AKH--E-GRCEFE- QIQCEA-------CQALVLRKD----KDR----HNDRECEERTLNCKYCKVTFNFKDI-K --AHD-----------------------------------------------------E- ICQKFPLQCKDCGK--KKIPREKFNDHAK-SCAKS--KSACPFSEVGCK---S--VVENG KISEHEHSST---MEHLRLLL--PMVLSMTRTRLDTSPSG-EWQEDSGLGLYRAPDD--- -------------------------------GCGAAAS-------------------VPS VDLDKKVSALENI---VCVLNREVERS-SLTLEAFSHQHRLD------------------ --------------QEKIENLSNK--------------------------IRQL-----E RSLTVKDLQLSEAEQMVR--E--LQYCTYD-GIFVWKITDFSHRRQEAVSGRA--PAMFS PAFYSSKYGYKMCLRLYLNGDGTGR-GTHLSLFF-VVMRSKYDALLKWPFSQK---RTIW AASKPNR------EEHIIDAFRPDI---TSTS-FQRP------------VSE--MNIASG CPLFCPLAKLAG-KS-PYLRDDTIFIKAIVD-LSGL------------------------ --------------------- >G_aculeatus_ENSGACP00000022084 ------------------------------------------------------------ --MARISLDCP--VSLP----------GIPLSVLSVPMENKYKCQQCLLVLRK------- ----------PVQAQ--------CGHRFCVHCFRQLT-------SYGP---KPCD---AC RQEEI-YEEPISIL-NSNE--AFPDNAAGREIASLPAKCLNQG--CDWTGSIKEYE---- ----------------------------------------------AQH--E-GRCELE- RMQCEA-------CKMSVLCTD----KDR----HNERECEERTLNCKYCKMTFNFKEI-K --AHD-----------------------------------------------------E- ICLKFPLQCKDCGK--KKIPREKFNDHSK-SCAKS--KSSCPFNDVGCK---Y--MMENG KLGDHEHSSA---VEHLRLLL--PLVLS-SVSLAGGDAAG-ELQEDSGLGLYRAPEEG-- ----------------------------VATGAGAAAS-------------------ALS LDMEKKVNALENI---VCVLNREVGRN-SVTLEAFSHQHRLD------------------ --------------QEKIENLSNK--------------------------LLQL-----E RTVSMKDLQLSATDQLLK--E--LQFCTYD-GIFVWKISDFSRRRQDAVAGRT--PAMFS PAFYSSKYGYKMCLRLYLNGDGTGR-GTHLSLFF-VVMRGKCDALLKWPFSQK---VTLM LLDQNNR-------EHIIDAFRPDV---TSTS-FQRP------------ISE--MNIASG CPLFCPLAKLAG-KS-PYLRDDTIFIKAIVD-LTGL------------------------ --------------------- >A_carolinensis_ENSACAP00000006987 -------------------------------------------------A---------- --SANVTPPGSLDEDQV----------GFPKEILGTELEGKYLCSECGNILRR------- ----------PFQAQ--------CGHRYCASCLQRLI-------SSGP---QKCG---AC IQEGI-YEDGVSIL-ETGS--AFPDNAARREVESLPAICANEG--CAWKGTIKEYE---- ----------------------------------------------SGH--G-GSCPWA- LATCPS-------CRGPVRRRD----QER----HAARECPQRSLSCKFCKALCHFPQI-K --AHD-----------------------------------------------------E- VCPKFPLTCEGCGK--RKIPREKFPEHVK-SCSKC--KAPCRFQPIGCN---V--VVSPS RWDE-AGPII---YKYC------------------------------------------- ------------------------------------------------------------ ------------I---IHYSNWIWGRV-RVTLPSF------------------------- -----------------LPSLW-Q--------------------------VRQL-----E RSLASKDLALAEMEHSLQ--E--MEAASFD-GIFIWKISDFTKKRQ-AVAGRS--PAIFS PAFYTGKYGYKMCLRIYLNGDGTGR-GTHLSLFF-VVMRGPCDALLRWPFNQK---V--- ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >G_gallus_ENSGALP00000002401 ------------------------------------------------------------ PRAGPAGGPGADAAVLP----------GGSRRGVGDVPEQKYLCSNCNNVLKK------- ----------ALQTL--------CGHRYCSACLSWIV-------RNNK--NPVCQ---KC KEEDPSTLSEGSLL-AEER--AFGDAAINKEISELRVHCVTLG--CSWCGTMKNFE---- -----------------------------------------------EH--Q-ILCEYA- LIPCHT------GCGHVVMRKK----LAD----HLENGCVNNVTVCHKCKQSLSSSEY-Q --PH-------------------------------------------------------- -CPRKPKVCRSEPAVILMTGTFMLSDHLR-ASSVS--MDGCRFSEVGCS---F--GGSKE KIKEHEKAAV---GTHMLLLL--QYIKQLKANLCTVSKAA-------------------- -------------------------------NGFISQTELN------------------- --LENKLHVFENI---VAVLNKEVETS-NLEITAFRRQSELD------------------ --------------QNVIRGLELK--------------------------IAEL-----H HCLTQKDAGLSRLHKSLV--F--SEQTSYD-GVFLWKITDVNQKLQDSVTGRV--VSLYS PAFYTAKYGYKVCLRIYLNGDGMGK-GTHVSLFF-VVMKGDYDALLPWPFRHK---VTFM LLDQNNR-------EHIIDAFRPDL---ASAS-FQRP------------VND--MNVASG CPTFLPLTKLQSPKH-AYVKEDTLFLKCIID-LTAV------------------------ --------------------- >T_guttata_ENSTGUP00000006737 ------------------------------------------------------------ -----------------------------------DVPGHKFLCSNCNNILKK------- ----------ALQTL--------CGHRYCSACLAWIL-------RNNK--NAICQ---KC KEEDPNTLGEESLL-AEER--AFGDAAINKEISELRVHCVTLG--CSWSGIMKDFE---- -----------------------------------------------EH--Q-SLCEYA- LIPCHT------GCGHVVMRRK----LAD----HLENGCVNNVTVCQQCQCSLATSEC-Q --VRT------------------------------------------------------- ----FLSQIKAFQLVLIISSTFFFSSHS--TSSSN--KDGCCFSEVGCA---F--RGSKE KIQEHQNSAV---GAHMLLLL--QHMRQLQGTLCS------------------------- -------------------------------KGFSPRPELN----------------KVI SELENKLHVFENI---VAVLNKEVESS-NLEIQAFRRQSELD------------------ --------------QNVIRGLELK--------------------------IAEL-----H QCLTQKDAGLSSLHKSLL--F--SEQASYD-GIFLWKITEVARKLQDSVTGRT--VSLYS PAFYTAKYGYKVCLRVYLNGDGTGK-GTHMSLFF-VVMKGDYDALLPWPFRHK---VTFM LLDQNNR-------EHIIDAFRPDL---TSAS-FQRP------------VND--MNVASG CPMFLPLAKLQSPKH-GYVREDTLFLKCIIE----------------------------- --------------------- >D_rerio_ENSDARP00000091948 ------------------------------------------------------------ -SGSASDPSLNGVSSTP----------GFPQSICDEVPKDKYLCSNCNNVLNK------- ----------ARQTV--------CGHRYCLACVNWLV-------RNNK--DLVCT---KC KGEDSNVESDTSVL-TPNQ--FFNDVAINKEILDLKVHCANQG--CPWRSTLKNFE---- ----------------------------------------------QDH--Q-SQCEYA- LIPCNI------GCGIMVQRKT----LAT----HLESGCPNNKTACPSCTSVLTPREL-Q --V--------------------------------------------------------- LLKKEKHVCPSSGDKKTAKTDKKQKNNQP-ANSKK--KEPCIFSDVGCP---F--KGNPD KVKEHESCSH---AGHLQLLL--DVTRALQRTLNSATERVYQDS-------PVFLEPGPN GSSL----APQADGDIETD------GGDPGVELAAG---------------------QQL DALQQKVQVIENI---ISALNREVEKT-QISVVAMNRDHCNS------------------ --------------QQIIQHLEAT--------------------------VAEL-----Q QRLVRKDILISSLQQSIS--A--QQDVSYD-GTFYWRVCDVSQKQREAANSQK--ISQYS PAFYTARYGFKVCLRLYLNGDGAGK-GSHISLFF-VIMKGEYDPILSWPFKHK---VTFF LLDQNQR-------EHVIDAFRPDL---SSMS-FHQP------------VSD--MNVASG CPLFFPLKKLRSPKH-AYCKDDTIYIKCVVD-TSS------------------------- --------------------- >O_anatinus_ENSOANP00000001757 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AFSDAAINKEISELNVHCVTPG--CSWTGLMKNFE---- ---------------------------------------------PQDH--Q-AECDCA- LIPCHA------GCGLMIMRKK----LPD----HLENGCAKSPTTCLKCKQTFCSMEY-- ------------------------------------------------------------ ----------------------QFNSPGS-TASRI--QDGCPFSVIGCS---FM-HGSRE KVKEHETSSM---DMHLGLLL--QAVSQTKANQGDC------------------------ -----------------------------EEELALQRFMRE----------------KLI SDLEEKLHVFENI---VAVLNKEVESS-NMAIAASIHQSNLD------------------ --------------RDMILRLEQR--------------------------VLDL-----H QTLAQKDLALARLKQSLQ--F--SELASYD-GIYLWKITDFSRKCHESLCGRT--TSLFS PVFYTARYGYKVCLRVYLNGDGTGK-GTHISLFF-VIMKGEYDSLLQWPFRNK---VTFM LLDQNNR-------EHVIDAFRPDL---NSAS-FQKP------------QGE--MNVASG CPMFFPLNKLQSPKH-AYVKDDTLFLKCIIE-TNS------------------------- --------------------- >T_rubripes_ENSTRUP00000013348 -----------------------MSAGRSTDGREVQIPLQQAAPSLAMPLSVA------- -PLLTSHCVPAGFLPLH----------GGFRDHFVEALEAKYCCESCRLVLCQ------- ----------PRQTE--------CGHRFCQSCINDIL-------SHPN---PVCP---AD TEP----------L-FKDK--VFRDVCCHREIMALKVYCRSEANGCQEQMRLQQIP---- -----------------------------------------------DH--L-NTCPFF- EVPCPLG-----KCKERMMRKE----IPE----HLSWKCKYRETSCEFCMTKMPLTEL-Q --KHK-----------------------------------------------------ET VCPAFPVSCPNHCSL-SSLPRSELSSHQH-ECPKA--QVSCPFHGYGCT---F--KGLNQ VMRQHESSSA---AEHLRMMA--KRNSALESKLDDVKGEL-----------------LER FKVL--PVLSSRVAELESS-NDELREKNRQTEQKLGTMQKL-----------MSSHSEKL LELELELRSLRGL---RDEVE-------NLRGTLESVRTRLNALEQGGRSGSGS------ --------------THTLASLEAQ--------------------------MNRH-----D DMLSVHDIRLADMDLRFQ--V--LETASYN-GTLIWKIRDYKRRKQEAVAAKT--LSLYS QPFYTGYFGYKMCARIYLNGDGMGK-GTHLSLFF-VVMRGEYDALLPWPFKQK---VTLM LMDQGPL------KKHLGDAFKPDP---NSSS-FRRP------------VVE--MNIASG CPLFVSQSVLETG---SYIKDDTIFIKVTVD-TSDL-----------------------P EP------------------- >T_nigroviridis_ENSTNIP00000005138 ------------------------------------------------------------ -----PAGGPAGFQPLH----------GGFRDHFVEAPEAKYCCESCRLVLCQ------- ----------PRQTE--------CGHRFCQSCITQLL-------GHAN---PVCP---AD MEP----------L-FKDK--IFRDVCCHREIMALKVYCRSEANGCQEQMRLQQIP---- -----------------------------------------------DH--L-NVCPFF- EVPCPLG-----KCKERMMRKE----IPD----HLSWKCKFRESSCEFCMTKMPLTEL-Q --KHK-----------------------------------------------------ET VCPAFPVSCPNHCSF-SSLPRSELSNHQH-ECPKA--QVSCQFHGYGCT---F--KGLNQ LMRQHESTSA---AEHLRMMA--KRNSMLEGKLDDVKGEL-----------------LER LKHL--PVVSSRVSELENA-SDELREKNRQMEQKLATMQKL-----------MSSHSEKL LEVELELRALRGL---RDEVE-------NLRGSLEGFRTRLSALEQGGRGGSGS------ --------------THTLASLEAQ--------------------------MNRH-----D DMLSVHDIRLADMDLRFQ--V--LETASYN-GTLIWKIRDYKRRKQEAVAAKT--LSLYS QPFYTGYFGYKMCARIYLNGDGMGK-GTHLSLFF-VVMRGEYDALLPWPFKQK---VTLM LMDQGPL------KKHLGDAFKPDP---NSSS-FRRP------------VVE--MNIASG CPLFVSQSVLETG---SYIKDDTIFIKVTVD-TSDL-----------------------P EP------------------- >G_aculeatus_ENSGACP00000005703 -------------------------------GGRCRFPLQQVAPSLTPALSVASPVHRQV NPWPPSDTTPQRFLPLH----------KGFRDHFALTPEAKYCCETCSLVLCQ------- ----------PRQTE--------CGHRFCQSCINDIL-------SHPN---PVCP---AD MEP----------L-FKDK--IFRDVCCHREIMALKVYCRSEANGCQEQMSLQQIP---- -----------------------------------------------DH--L-NVCPFF- EVPCPLG-----KCKERMMRKE----IPD----HLSWKCKHRETSCEFCMTKMPLTDL-Q --KHK-----------------------------------------------------ET VCPAFPVSCPNHCSV-SSLPRSELSSHQN-DCPKA--QVCCQFQRYGCT---F--QGLNQ DMRQHESTSA---GEHLRMIA--NKNSVLENKVEDIKGEL-----------------LER YKVL--PALSSRLSELENQ-SDELREKNRQVEQKLATMQKL-----------MSSHSEKL LEVELELRSLRVL---RDEVE-------NLRGTLENVRTRLNTLEQGGRSGTGST----- --------------THTLATLENQ--------------------------LKRH-----D EMLSVHEIRLADMDLRFQ--V--LETASYN-GTLIWKIRDYKRRKQEAVGAKT--LSLYS QPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VVMRGEYDALLPWPFKQK---VTLM LMDQGPL------RKHLGDAFKPDP---NSSS-FRRP------------AAE--MNIASG CPLFVSQSVLETG---TYIKDDTIFIKVTVD-TSDL-----------------------P DP------------------- >X_tropicalis_ENSXETP00000027864 -----------------------MDTGKKTDPSASV-----QK----------------- -ANPDRSLATTIYVPEQ----------GGYKERFLKPVEEKYKCEKCRLVLCN------- ----------PRQTE--------CGHRFCETCMNAIL-------SSTS---PQCM---AC EDN----------I-TKDK--VFKDNCCRREVLALQMFCRNETRGCKELITLGNLL---- -----------------------------------------------IH--LKSDCQFE- ELSCPRA-----DCKEKVIRKD----LSD----HIEKTCKYRETPCKFCRNQVPLVEM-Q --KHE-----------------------------------------------------DV DCPSVVISCPHMCSV-KSLLRSELNAHLL-ECVNA--PSTCSFKRYGCT---F--KGTNQ QIKAHEASSA---VQHVNLMK--EWSNYLEAKVSMLQNES-----------------SEK NKSI--QILHNQMCSFEIE-IERHKEQLRNNEARIIQLQRV-----------IEGQADKL KDLDKEIRNLRQT---GDEAD-------GMKSNYESLQNRLSQLEVMAKNA--A------ --------------SWNPGVLETQ--------------------------INRH-----D QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYS QPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VSLM LMDQGPS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASG CPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P DP------------------- >E_caballus_ENSECAP00000011833 -----------------------MESSKKMDSPGALQTNPPLK----------------- -LHPDRSTSTAVFVPEQ----------GGYKERFVKTVEDKYKCEKCRLVLCN------- ----------PKQTE--------CGHRFCETCMAALL-------SSSS---PKCT---AC QEG----------I-IKDK--VFKDNCCKREILALQIYCRNESRGCVEQLTLGHLL---- -----------------------------------------------VH--LKNDCQFE- ELACVRP-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMITL-Q --KHE-----------------------------------------------------DT ECPCVVVSCPHKCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCI---F--QGTNQ QIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-----------------VEK NKSI--QSLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKSAGQA------ --------------ARNTGLLESQ--------------------------LSRH-----D QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYS QPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM LMDQGSS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASG CPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P DP------------------- >D_rerio_ENSDARP00000038596 -----------------------MSAGRNV---EQQIPLQQRPPSLAMP----------- -SMAQRPRPEPGFSPLH----------GGFRDHFVTTPEPKYCCETCRLVLCN------- ----------PRQTE--------CGHRFCESCINELL-------SKPN---PVCP---AD LLP----------L-FEDK--IFRDVCCNREIMALKVYCRSEKNGCKEQMCLQQVM---- -----------------------------------------------EH--L-VICPYF- EVPCPLG-----KCKEKMMRKD----MPE----HLSRKCKHREVTCEFCSLKMALTEL-Q --KHK-----------------------------------------------------ET VCPAFPVACPNHCSF-SSILRSELSSHQH-DCPKA--QVTCSFIRYGCS---Y--KGLNQ EMREHESSFA---SEHLRMMA--VRNTTLEAKVEDVKSEL-----------------MER YKVL--PSLSSRLAEVERQ-YEEMREKNRQLEQKLVSMQML-----------MSSHSEKL LEVEMELRELRPLRAMREEVE-------TLRGSVESMRSMVSSLDSSCVNSASG------ --------------SHTLASLEQQ--------------------------LTRH-----D DLMSVHDVRLAEMDLKLQ--V--LETASFN-GTLIWKIRDYKRRKQEAVVSKT--LSLYS QPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VVMRGEYDALLQWPFKQK---VTLM LMDQGPA------RKHLGDAFKPDP---SSSS-FRRP------------TGE--MNIASG CPLFVAQTVLENG---TYIKDDTIFIKVTVD-TSDL-----------------------P DP------------------- >P_pygmaeus_ENSPPYP00000007003 -----------------------MESSKKMDSPGALQTNPPLK----------------- -LHTDRSAGTPVFVPEQ----------GGYKEKFVKTVEDKYKCEKCRLVLCS------- ----------PKQTE--------CGHRFCESCMAALL-------SSSS---PKCT---AC QES----------I-VKDK--VFKDNCCKREILALQIYCRNESRGCAEQLTLGHLL---- -----------------------------------------------VH--LKNDCHFE- ELPCVRP-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMIAL-Q --KHE-----------------------------------------------------DT DCPCVVVSCPHKCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F--QGTNQ QIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-----------------VEK NKSI--QSLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKSAGQV------ --------------ARNTGLLESQ--------------------------LSRH-----D QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYS QPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM LMDQGSS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASG CPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P DP------------------- >P_troglodytes_ENSPTRP00000003288 -------------------------------------------------MAYSEEHKGMP CGFIRQNSGNSISLDFE----------PNIEYQFVERLEERYKCAFCHSVLHN------- ----------PHQTG--------CGHRFCQHCILSLR-------ELNT--VPICP---VD KEV----------I-KSQE--VFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQ---- -----------------------------------------------DH--L-QQCLFQ- AVQCSNE-----KCREPVLRKD----LKE----HLSAYCQFREEKCLYCKKDVVVINL-Q --NHE-----------------------------------------------------EN LCPEYPVFCPNNCA--KIILKTEVDEHLA-VCPEA--EQDCPFKHYGCA---V--TDKRR NLQEHEHSAL---REHMRLVL--EKNVQLEEQISDLHKSL-----------------EQK ESKI--QQLAETIKKLEKE-FKQFAQLFGKNGSFLPNIQVF------------ASHIDKS AWLEAQVHQLLQM---VNQQQNKFDLR-PLMEAVDTVKQKITLLENN------------- --------------DQRLAVLEEE--------------------------TNKH-----D THINIHKAQLSKNEERFK--L--LEGTCYN-GKLIWKVTDYKMKKREAVDGHT--VSIFS QSFYTSRCGYRLCARAYLNGDGSGR-GTHLSLYF-VVMRGEFDSLLQWPFRQR---VTLM LLDQSGK------KN-IMETFKPDP---NSSS-FKRP------------DGE--MNIASG CPRFVAHSVLENAKN-AYIKDDTLFLKVAVD-LTDL-----------------------E DL------------------- >C_familiaris_ENSCAFP00000026713 -----------------------MESSKKMDSPGTLQTNPPLK----------------- -LHPDRSAGTSIFVPEQ----------GGYKERFVKTVEDKYKCEKCRLVLCN------- ----------PKQTE--------CGHRFCETCMAAVL-------SSSS---PKCT---AC QES----------I-IKDK--VFKDNCCKREILALQIYCRNEGGGCTEQLTLGHLL---- -----------------------------------------------VH--LKNDCQFE- ELSCVRA-----DCKEKVLRRD----LRD----HVEKACKYREATCPHCKSQVPMITL-Q --KHE-----------------------------------------------------DT ECPCVVVSCPHKCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F--QGTNQ QIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-----------------VEK NKSI--QSLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKSAGQA------ --------------ARNTGLLESQ--------------------------LSRH-----D QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYS QPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM LMDQGSS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASG CPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P DP------------------- >A_carolinensis_ENSACAP00000000193 -----------------------MDTSKKTDPPVSVETV-QQK----------------- -ANVERSPVPSVYIPEQ----------GGYKEKFVNAVEDKYKCEKCRLILCN------- ----------PRQTE--------CGHRYCETCMNALL-------SCTI---PKCT---AC QET----------I-VKEK--IFKDNCCRRELLALQIFCRNENKGCREQLTLGQLL---- -----------------------------------------------TH--LRNDCLFE- ELPCPRV-----DCKEKILRKD----LPD----HAEKTCKYRETTCKYCKSQVPIIMI-Q --KHE-----------------------------------------------------DA DCPCVMVTCPHKCSV-SALLRKELNAHLS-ECINA--PSTCSFKRYGCT---F--QGTNQ QVKAHETSSA---VQHVDLLK--EWSNCLENKVAMLQNES-----------------LEK NKSI--QTLHNQICSFEIE-IERQKEMLRSNESKIHHLQRV-----------IDSQAEKL KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKTAGQG------ --------------ARNAGLLESQ--------------------------LSRH-----D QMLSVHDIRLADMDLRFQ--V--LETASYN-GILIWKIRDYKRRKQEAVMGKT--LSLYS QPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM LMDQGPS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASG CPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P DP------------------- >P_troglodytes_ENSPTRP00000011503 -----------------------MESSKKMDSPGALQTNPPLK----------------- -LHTDRSAGTPVFVPEQ----------GGYKEKFVKTVEDKYKCEKCHLVLCS------- ----------PKQTE--------CGHRFCESCMAALL-------SSSS---PKCT---AC QES----------I-VKDK--VFKDNCCKREILALQIYCRNESRGCAEQLTLGHLL---- -----------------------------------------------VH--LKNDCHFE- ELPCVRP-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMIAL-Q --KHE-----------------------------------------------------DT DCPCVVVSCPHKCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F--QGTNQ QIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-----------------VEK NKSI--QSLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKSAGQV------ --------------ARNTGLLESQ--------------------------LSRH-----D QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYS QPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM LMDQGSS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASG CPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P DP------------------- >M_mulatta_ENSMMUP00000038268 -------------------------------------------------MAYSEEHRGMP CGFIRQNSGNSISLDFE----------PNIEYQFVERLEERYKCAFCRSVLHN------- ----------PHQTG--------CGHRFCQHCILSLR-------ELNT--VPICP---VD KEV----------I-KSQE--VFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQ---- -----------------------------------------------DH--L-QQCLFQ- AVQCSNE-----NCQEPVLRKD----LKE----HLSAYCQFREEKCLYCKKDVVVINL-Q --NHE-----------------------------------------------------EN LCPEYPVFCPNNCA--KIILKTEVDEHLA-VCPEA--EQDCPFKHYGCA---V--TDKRR NLQEHEHSAL---REHMRLVL--EKNVQLEEQISDLHKSL-----------------EQK ESKI--QQLAETIKKLEKE-FKQFAQLFGKNGSFLPNIQVF------------ASHIDKS AWLEAQVHQLLQM---VNQQQNKFDLR-PLMEAVDTVKQKITLLENN------------- --------------DQRLAVLEEE--------------------------TNKH-----D THINIHKAQLNKNEERFK--L--LEGTCYN-GKLIWKVTDYKMKKREAVDGHT--VSIFS QSFYTGRCGYRLCARAYLNGDGSGK-GTHLSLYF-VVMRGEFDSLLQWPFRQR---VTLM LLDQSGK------KN-IMETFKPDP---NSSS-FKRP------------DGE--MNIASG CPRFVAHSVLENAKN-AYIKDDTLFLKVAVD-LTDL-----------------------E DL------------------- >M_musculus_ENSMUSP00000021706 -----------------------MESSKKMDAAGTLQPNPPLK----------------- -LQPDRGAG-SVLVPEQ----------GGYKEKFVKTVEDKYKCEKCRLVLCN------- ----------PKQTE--------CGHRFCESCMAALL-------SSSS---PKCT---AC QES----------I-IKDK--VFKDNCCKREILALQVYCRNEGRGCAEQLTLGHLL---- -----------------------------------------------VH--LKNECQFE- ELPCLRA-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMIKL-Q --KHE-----------------------------------------------------DT DCPCVVVSCPHKCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F--QGTNQ QIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-----------------VEK NKSI--QSLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKSAGQA------ --------------ARNTGLLESQ--------------------------LSRH-----D QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYS QPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM LMDQGSS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASG CPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P DP------------------- >P_pygmaeus_ENSPPYP00000000253 -------------------------------------------------MAYSEEHKGMP CGFIRQNSGNSISLDFE----------PNIEYQFVERLEERYKCAFCHSVLHN------- ----------PHQTG--------CGHRFCQHCILSLR-------ELNT--VPICP---VD KEV----------I-KSQE--VFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQ---- -----------------------------------------------DH--L-QQCLFQ- AVQCSNE-----KCREPVLRKD----LKE----HLSAYCQFREEKCLYCKKDVVVINL-Q --NHE-----------------------------------------------------EN LCPEYPVFCPNNCA--KIILKTEVDEHLA-VCPEA--EQDCPFKHYGCA---V--TDKRR NLQEHERSAL---REHMRLVL--EKNVQLEEQISDLHKSL-----------------EQK ESKI--QQLAETIKKLEKE-FKQFAQLFGKNGSFLPNIQVF------------ASHIDKS AWLEAQVHQLLQM---VNQQQNKFDLR-PLMEAVDTVKQKITLLENN------------- --------------DQRLAVLEEE--------------------------TNKH-----D THINIHKAQLSKNEERFK--L--LEGTCYN-GKLIWKVTDYKMKKREAVDGHT--VSIFS QSFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYF-VVMRGEFDSLLQWPFRQR---VTLM LLDQSGK------KN-IMETFKPDP---NSSS-FKRP------------DGE--MNIASG CPRFVAHSVLENAKN-AYLKDDTLFLKVAVD-LTDL-----------------------E DL------------------- >R_norvegicus_ENSRNOP00000010906 -----------------------MEPSKKMGAAGAAQPNPPLK----------------- -LQPDRGAA-SVLVPEQ----------GGYKEKFAKTVEDKYKCEKCRLVLCN------- ----------PKQTE--------CGHRFCESCMAALL-------SSSS---PKCT---AC QES----------I-IKDK--VFKDNCCKREILALQIYCRNEGRGCVEQLTLGHLL---- -----------------------------------------------VH--LKNECQFE- ELPCLRA-----DCKEKVLRRD----LRD----HVEKACKYREATCAHCKSQVPMITL-Q --KHE-----------------------------------------------------DT DCPCVVVSCPHKCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F--QGTNQ QIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-----------------VEK NKSI--QSLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKSAGQA------ --------------ARNTGLLESQ--------------------------LSRH-----D QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYS QPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM LMDQGSS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASG CPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P DP------------------- >G_gallus_ENSGALP00000036699 ------------------------------------------R----------------- -ANPDRSPSASIYVPEQ----------GGYKEKFVNAVEDKYKCEKCHFILCN------- ----------PKQTE--------CGHRFCETCMNALL-------STPS---PKCT---AC QES----------I-VKDK--VFKDNCCRRELLALQIYCRNENKGCKEQLSLGQLL---- -----------------------------------------------MH--LKTDCQFE- ELPCPRA-----DCKEKILRKD----LPD----HVEKTCKYRETTCKYCKSQVPMIML-Q --KHE-----------------------------------------------------DT DCPCVMVSCPHKCSV-KTLMRSELNAHLS-ECINA--PSTCSFKRYGCT---F--QGTNQ QIKAHEASSA---VQHVNLLK--EWSNALENKVALLQNES-----------------LEK NKSI--QTLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKTAGQG------ --------------ARNTSMLETQ--------------------------LSRH-----D QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYS QPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM LMDQGPS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASG CPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P DP------------------- >O_anatinus_ENSOANP00000023053 -----------------------MDSSKKMDPS-LVQQNVPPK----------------- -GNPDRGPGASIYVPEQ----------GGYKERFVKTVEDKYKCEKCHLILCN------- ----------PKQTE--------CGHRFCETCMNMLL-------SSSS---PKCS---AC QEN----------V-IKDK--VFKDNCCKREILALQIYCRNENRGCTEQLTLGHLL---- -----------------------------------------------VH--LKSDCQFE- ELSCPRA-----DCKEKVLRKD----LPD----HIEKSCKYREATCKYCTSQVPMITL-Q --KHE-----------------------------------------------------DT ECPCVVVSCPHKCSV-QTLLRSELNAHLS-ECINA--PSTCSFKRYGCT---F--QGTNQ QIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-----------------VEK NKSI--QSLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKNAGQA------ --------------ARNTGMLETQ--------------------------LSRH-----D QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYS QPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM LMDQGSS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASG CPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P DP------------------- >H_sapiens_ENSP00000376500 -----------------------MESSKKMDSPGALQTNPPLK----------------- -LHTDRSAGTPVFVPEQ----------GGYKEKFVKTVEDKYKCEKCHLVLCS------- ----------PKQTE--------CGHRFCESCMAALL-------SSSS---PKCT---AC QES----------I-VKDK--VFKDNCCKREILALQIYCRNESRGCAEQLMLGHLL---- -----------------------------------------------VH--LKNDCHFE- ELPCVRP-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMIAL-Q --KHE-----------------------------------------------------DT DCPCVVVSCPHKCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F--QGTNQ QIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-----------------VEK NKSI--QSLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKSAGQV------ --------------ARNTGLLESQ--------------------------LSRH-----D QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYS QPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM LMDQGSS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASG CPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P DP------------------- >H_sapiens_ENSP00000336825 -------------------------------------------------MAYSEEHKGMP CGFIRQNSGNSISLDFE----------PSIEYQFVERLEERYKCAFCHSVLHN------- ----------PHQTG--------CGHRFCQHCILSLR-------ELNT--VPICP---VD KEV----------I-KSQE--VFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQ---- -----------------------------------------------DH--L-QQCLFQ- PVQCSNE-----KCREPVLRKD----LKE----HLSASCQFRKEKCLYCKKDVVVINL-Q --NHE-----------------------------------------------------EN LCPEYPVFCPNNCA--KIILKTEVDEHLA-VCPEA--EQDCPFKHYGCA---V--TDKRR NLQQHEHSAL---REHMRLVL--EKNVQLEEQISDLHKSL-----------------EQK ESKI--QQLAETIKKLEKE-FKQFAQLFGKNGSFLPNIQVF------------ASHIDKS AWLEAQVHQLLQM---VNQQQNKFDLR-PLMEAVDTVKQKITLLENN------------- --------------DQRLAVLEEE--------------------------TNKH-----D THINIHKAQLSKNEERFK--L--LEGTCYN-GKLIWKVTDYKMKKREAVDGHT--VSIFS QSFYTSRCGYRLCARAYLNGDGSGR-GSHLSLYF-VVMRGEFDSLLQWPFRQR---VTLM LLDQSGK------KN-IMETFKPDP---NSSS-FKRP------------DGE--MNIASG CPRFVAHSVLENAKN-AYIKDDTLFLKVAVD-LTDL-----------------------E DL------------------- >T_guttata_ENSTGUP00000013203 ------------------------------------------R----------------- -ANPDRSPSASIYVPEQ----------GGYKEKFVNAVEDKYKCEKCHLILCN------- ----------PKQTE--------CGHRFCETCMNALL-------RSSS---PKCT---AC QES----------I-VKDK--VFKDNCCRRELLALQIYCRNENKGCKEQLSLGQLL---- -----------------------------------------------MH--LRTDCQFE- ELPCPRA-----DCKEKILRKD----LPD----HVEKTCKYRETTCKYCKSQVPMIML-Q --KHE-----------------------------------------------------DT ECPCVMVSCPHKCSV-KTLMRSELNAHLS-ECINA--PSTCSFKRYGCT---F--QGTNQ QIKAHEASSA---VQHVNLLK--EWSNALENKVALLQNES-----------------LEK NKSI--QTLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKTAGQG------ --------------ARNTSLLETQ--------------------------LSRH-----D QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYS QPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM LMDQGPS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASG CPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P DP------------------- >B_taurus_ENSBTAP00000017918 -----------------------MEPSKKLDAAGALPANPPLK----------------- -LHPERGAGPAVLVPEQ----------GGYKERFVKAVEDKYKCEKCRLVLCS------- ----------PKQTE--------CGHRFCETCMGALL-------SSSS---PKCT---AC QEV----------I-IKDK--VFKDNCCKREILALQIFCRNEGRGCTEQLALGHLL---- -----------------------------------------------VH--LKNDCQFE- ELPCVRA-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMVTL-Q --KHE-----------------------------------------------------DT ECPCVAVSCPHKCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F--QGTNQ QIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-----------------VEK NKSI--QSLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKSAGQA------ --------------ARNTGLLESQ--------------------------LSRH-----D QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYS QPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM LMDQGSS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASG CPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P DP------------------- >M_domestica_ENSMODP00000024498 ---------------------------------------------------------LTD TAPVGPHLIPDENEFPF----------GYPASICQGTPEPKYLCCGCHNVLKK------- ----------AQQTL--------CGHRYCAACLSWIL-------SSPN------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------D ------------------------------------------------------------ ----------------GTLFFWGFFQNSL-VPAED--QDRCPFADIGCS---F--KGGQE RVKEHEASSL---SDHLRRLL--ELVIRTKVQAGPSRGRGASGRRQAAEPEPKAPERNLS DLQL--QGAVEVNGDLEAD-YFHAASSDSEEELALQRFMKE----------------KLL SELEEKLRVFENI---VTVLNKEVEAS-HLAIAASVHQSGLT------------------ --------------QDLILSLEQR--------------------------VVDL-----Q QTLTQKDLALTKLEQTLH--L--LEEASYD-GVYLWKITNFTRRCHESACGRT--VSLFS PAFYTARYGYKLCLRIYLNGDGMGK-GTHLSLFI-VVMKGKYDALLEWPFRNKAIPVTFM LLDQNNR-------EHVTDSFHPDL---TSGS-FQKP------------QGE--SNIASG RPMFFPLNKLQSSKH-AYVKDDTLFLKCVIE-TNS------------------------- --------------------- >O_anatinus_ENSOANP00000013484 -------------------------------------------------SMGSEELTIGS RAFSHQNSSSCISLDFE----------PDIQYQFVEQLEERYKCTFCHSVLHN------- ----------PHQTS--------CGHRFCQHCILSLR-------ELNN--FPTCP---ID KKI----------I-QLQE--VFKDNCCKREVLNLQVFCKN-APGCNSKMILGRYQ---- -----------------------------------------------DH--L-QQCLFQ- PVQCSNE-----SCQEKVLRKD----MKD----HLGCHCKFREEKCQYCQKYVVAIDL-Q --NHE-----------------------------------------------------EN FCPDYPVSCPFSCC--QIIPRTEVDEHIS-VCPEA--EQDCPYKQYGCL---I--KDKRR NLREHENAAL---REHMLLVL--DKNSRLEEKISDLHRSL-----------------EVK ELKI--QQLAEMVKKFEKE-FRQVMQLFSKNGNLLANTQIL------------ANHIDKS TWLETQVRQLLHM---ANQQQSKFDLK-SLMETIDTVKQKIALLETY------------- --------------DQRLVVLKDQ--------------------------TRQH-----D AHINAHKAQLNKNEERFK--L--LEGTCYN-GKLIWKVTDYKMKKREAMEGRS--VSIFS QPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYF-VVMKGEFDSLLQWPFKQK---VTMM LLDQSGK------KNHIVEIFKADP---NSSS-FKRP------------EGE--MNIASG CPCFVDHSKLENVKN-TFIKEDTLFMKVVVD-LTDL-----------------------E EL------------------- >M_domestica_ENSMODP00000016701 -----------------------MDSSKKMDPPNPLQTV-QQK----------------- -ANPDRGAAVSIYVPEQ----------GGYKEKFVKPVEDKYKCEKCHLILCN------- ----------PKQTE--------CGHRFCETCMHVLL-------SAPS---PKCT---AC QEN----------I-IKDK--VFKDNCCKREILALQIYCRNESRGCTEQLTLGHLL---- -----------------------------------------------VH--LKSECQFE- ELPCVRA-----DCKEKILRKD----LQD----HVEKSCKYREATCQYCKSQVPMITL-Q --KHE-----------------------------------------------------DT ECPCVVVSCPHKCSV-QTLLRSELNAHLS-ECINA--PSTCSFKRYGCT---F--QGTNQ QIKTHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-----------------VEK NKSI--QSLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKSAGQA------ --------------ARNTGLLETQ--------------------------LSRH-----D QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYS QPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM LMDQGSS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASG CPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P DP------------------- >E_caballus_ENSECAP00000005414 -------------------------------------------------MAYSEEQGGVP CGFIRQNSSNSVSLDFE----------PNTEYRFVEQLEERYKCAFCHSVLHN------- ----------PHQTG--------CGHRFCQHCILSLR-------ELNA--VPLCP---VD KEV----------I-KSQE--VFKDNCCKREVLNLYVYCKN-APGCNAKIILGRYQ---- -----------------------------------------------DH--L-QQCLFQ- AVQCSNE-----HCQESVLRKN----LKE----HLSAYCQFREEKCLYCKKDVVVINL-Q --NHE-----------------------------------------------------EN MCPEYPVSCPNKCL--QIIPRTEVDEHLA-VCPEA--EQDCPFKQYGCP---V--KDKRG NLQEHEHSAL---RDHMLLVL--EKNLQLEKQISDLHRSL-----------------ERK ESKI--QQLTETVNKFEKE-FKQFAQLFGKNGSFLSNIQLL------------ASHLDKS AWLEAQVRQLLQM---ANQQETKFDLR-ALMEAIDTVKQKITLLETH------------- --------------DQRIVVLEGE--------------------------TNKH-----D VHINIHKAQLNKNEERFK--L--LEGACYN-GKLIWKVTDYKMKKREALEGHT--VSIFS QPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYF-VVMRGEFDSLLQWPFRQR---VTLM LLDQSGK------KNHIMETFKADP---NSSS-FKRP------------DGE--MNIASG CPRFVAHSTLENAKN-TYIKDDTIFLKVAVD-LTDL-----------------------E DL------------------- >T_guttata_ENSTGUP00000003276 --------------------------------------------------MACDEPAALS GIFTRQNSSSTSSLDFE----------PHADYRFVESLEERYKCAYCHLVLRN------- ----------PHQTG--------CGHRFCQQCILALR-------ELNA--VPTCP---VD KET----------I-KMHE--VFKDNCCKREVLNLHVFCKN-FPDCSSKVILGRYQ---- -----------------------------------------------EH--L-QQCLFE- CTQCTND-----GCRDRVLRKD----LKE----HLRQQCKFREERCQYCNTYVVFINI-E --NHE-----------------------------------------------------KN DCPDYPVPCLQNCS--QIILKKEIEKHHA-VCPEA--EVDCPYKQYGCH---V--KVKRG KLAEHENSAL---REHMLQIL--DKNSRLEEQISDLYKNL-----------------EYK EIKI--QQLADAIKKCEKE-FRQYTQLFGNNSNLMVSTQAL------------ASHLDKS ARLESQVKQLIQM---ANQQQSKLDLQ-PLLDTIENVKQKIALMETY------------- --------------DQRLVVLEDQ--------------------------SSKH-----D LQINIHKAQLNKNEERFK--L--LEGTCYN-GKLIWKITDYQKKKREAVEGRV--LSIAS QPFYTSRCGYRLCARAYLNGDGSGK-GTHISLYF-VVMRGEFDSLLLWPFKQK---VTLM LLDQSGK------KNHIVDVFRADP---NSSS-FKRP------------DGE--MNIASG CPRFVPHTVLESTKN-TYIRDDTLFLKVVVD-LTDL-----------------------E EL------------------- >G_gallus_ENSGALP00000016021 --------------------------------------------------MACDELTGVS GIFTRQNSASAVSLDFE----------PDTDYKFVETLEDRYKCAYCHSVLHN------- ----------PHQTG--------CGHRFCQQCILTLR-------GLNA--VPTCP---VD KET----------I-KMHE--VFKDNCCKREVLNLYVFCKN-LPDCNSKIILGRYQ---- -----------------------------------------------EH--L-QQCLFE- SVQCTND-----GCCDQILRKD----LKD----HLSQHCKFREEMCQYCNKYVVLINI-K --NHE-----------------------------------------------------EN DCPDYPMPCLQNCS--QIILKKEIEKHHT-VCPET--EVDCPYKQYGCL---I--KVKRG KLAEHENGAL---REHMLQIL--DKNSRLEEQISDLYKSL-----------------ECK EIKI--QQLAEAVKKCEKE-FRQFTQLFGKNSNLMVSTQTL------------ASHLDKS ARLESQVKQLIQM---ANQQQSKLDLR-PLFDTIENVKQKIALMETY------------- --------------DQRLAVLESQ--------------------------SSKH-----D LQINIHKAQLNKNEERFK--L--LEGTCYN-GKLIWKITDYKMKKKEAVEGRV--LSIFS QPFYTSRCGYRLCARAYLNGDGSGK-GTHVSLYF-VVMRGEFDSLLPWPFKQK---VTLM LLDQTGK------KNHIVEVFRADP---NSSS-FKRP------------DGE--MNIASG CPRFVPHTVLENTKN-TYVRDDTLFLKVVVD-LTDL-----------------------E EL------------------- >A_carolinensis_ENSACAP00000016112 -------------------------------------------------MASEDLACQVP NFYIRQNSTNAVSLDFE----------PDASYQFVEILEDRYKCTHCHLVLHN------- ----------PHQTG--------CGHRFCQRCIASLR-------ELSV--IPTCP---VD KEI----------I-KPHE--VFKDNCCKREVLNLQVYCRN-SPACNAKTSLGRYQ---- -----------------------------------------------DH--L-QQCLFE- SVQCTNE-----GCCEKVLQKD----LKE----HLGLHCNYRKELCRYCNQPVTSINV-K --THE-----------------------------------------------------RR DCPEYPLICPHGCT--QTILMKEAEEHIL-VCPAV--EIDCPYKQYGCP---A--KIKRG KVLEHENIYL---REHMLQIL--DRNSKLEDQISELYKNL-----------------EHK EIKI--QHLADMVKKCEKE-FRQFTQLYSKNNNLLASTQTL------------AIHIDKS ACLETQVRQLVQM---ANQQQSKFDLR-PLLETVENIKQKVAFLESY------------- --------------EQRLVVLEDL--------------------------SSQH-----D IHLGLHKAQLNKNEERFK--L--LEGTSYN-GKLIWKIVDYKTKKKEAVEGSC--LSIFS QPFYTSRCGYRLSTRAYLNGDGSGK-GTHVSLYF-VVMRGEFDSLLPWPFRQK---VTLM LLDQSGK------KNHIVETFKADP---NSSS-FKRP------------EGE--MNVASG CPRFVPHTLLENAKS-TYIKDDTIFLKVVVD-LTDL-----------------------E EL------------------- >B_taurus_ENSBTAP00000015940 -------------------------------------------------MAYFEEQGGVP CGFTRQNSGNSISLDFE----------PDAEYQFVERLEERYKCAFCHSVLHN------- ----------PHQTG--------CGHRFCHQCILALR-------ELDT--VPLCP---VD KEV----------I-KSQE--VFKDNCCKREVLNLYVFCKN-APRCNAKIILGRYQ---- -----------------------------------------------DH--L-QHCLFQ- PVQCSNE-----NCREPVLRKD----LKE----HLSAYCQFREEKCLYCKKDVVVINL-Q --NHE-----------------------------------------------------EN LCPDYPVSCPNKCL--QTIPRTEVDEHLA-VCPEA--EQDCAFKNYGCA---V--KDKRG NLQEHERSAL---RDHMLLVL--EKNFQLEEQISDLYKSL-----------------EQK ESKI--QQLAEMVKKFEKE-FKQFAQLFGKNGSFLSNMQVL------------ASHIDKS AWLEVQVRQLLQM---ANQQQSKFDLK-PLVEAIDTVKQKITLLETN------------- --------------DQRLVVLEGE--------------------------TNKH-----D AHINIHKAQLNKNEERFK--L--LESACYN-GKLIWKVTDYKLKKKEALDGHT--VSIFS QPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYF-VVMRGEFDSLLQWPFRQR---VTLM LLDQSGK------KNHIMETFKADP---NSSS-FKRP------------DGE--MNIASG CPRFVAHSTLENAKN-TYIKDDTLFLKVAVD-LTDL-----------------------E DL------------------- >P_troglodytes_ENSPTRP00000036416 ---------------------------------------------------------MAS SSGSSPRPAPDENEFPF----------GCPPTVCQDPKEPRALC---------------- ----------------------------CAGCLSENP-------RNGE------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DQ ICPKCRGEDLQSISP-GSRLRTQEKAHPE--VAEA--GVGCPFAGVGCS---F--KGSPQ SVQEHEVTSQ---TSHLNLLL--GFMKQWKARLGCGLESG-----------PMALEQNLS DLQL--QAAVEVAGDLEVD-CYRAPCSESQEELALQHFMKE----------------KLL AELEGKLRVFENI---VAVLNKEVEAS-HLALATSIHQSQLD------------------ --------------RERILSLEQR--------------------------VVEL-----Q QTLAQKDQALGKLEQSLR--L--MEEASFD-GTFLWKITNVTRRCHESACGRT--ISLFS PAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI-VIMRGEYDALLPWPFRNK---VTFM LLDQNNR-------EHAIDAFRPDL---SSAS-FQRP------------QSE--TNVASG CPLFLPLSKLQSPKH-AYVKDDTMFLKCIVE-TST------------------------- --------------------- >H_sapiens_ENSP00000362994 ---------------------------------------------------------MAS SSGSSPRPAPDENEFPF----------GCPPTVCQDPKEPRALC---------------- ----------------------------CAGCLSENP-------RNGE------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DQ ICPKCRGEDLQSISP-GSRLRTQEKAHPE--VAEA--GIGCPFAGVGCS---F--KGSPQ SVQEHEVTSQ---TSHLNLLL--GFMKQWKARLGCGLESG-----------PMALEQNLS DLQL--QAAVEVAGDLEVD-CYRAPCSESQEELALQHFMKE----------------KLL AELEGKLRVFENI---VAVLNKEVEAS-HLALATSIHQSQLD------------------ --------------RERILSLEQR--------------------------VVEL-----Q QTLAQKDQALGKLEQSLR--L--MEEASFD-GTFLWKITNVTRRCHESACGRT--VSLFS PAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI-VIMRGEYDALLPWPFRNK---VTFM LLDQNNR-------EHAIDAFRPDL---SSAS-FQRP------------QSE--TNVASG CPLFFPLSKLQSPKH-AYVKDDTMFLKCIVE-TST------------------------- --------------------- >M_domestica_ENSMODP00000003305 -------------------------------------------------SLTSAEYGSAS GDFLPQNSSSYISLDFE----------PNIDYQFVEQLEERYKCASCHSVLHN------- ----------PHQTG--------CGHRFCENCILSLR-------ELNT--VSICP---VD KEI----------I-KPKE--VFKDNCCKREVLNLQVFCKN-APHCAAKMILGRYQ---- -----------------------------------------------DH--L-LQCLFQ- SVQCSNE-----CCQERILRKD----LKN----HLELHCQFREEMCPFCNKDVVIIDL-Q --NHK-----------------------------------------------------EQ FCPNYPVSCPNNCL--QIITRTKVNEHIS-VCPEV--EQECAYKHYGCP---V--KDKRS NLKKHENSAL---REHMLLVL--ERNSRLEEQIFDLHKNL-----------------ELK ESKI--QQLSETVKKFEKE-FRQFVQLFGKNGNLLASTQVL------------ASHIDKS AWLETQVRELLEL---ANQQENKLDLK-PLINTIDTIKQKITLLETY------------- --------------DQRLVTLEGQ--------------------------TNRH-----D VHINVHKAQLNKNEERFK--M--LEGTCYN-GKLIWKVTDYKMKKKEATEGRT--VSIFS QPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYF-VVMKGEFDSLLQWPFKQR---VTMM LLDQSGK------KNHITEIFKADP---NSSS-FKRP------------DGE--MNIASG CPRFVAHSTLESTKN-TYIKEDTLFMKVVVD-LSDL-----------------------E DL------------------- >M_musculus_ENSMUSP00000082710 -------------------------------------------------MAHSEEQAAVP CAFIRQNSGNSISLDFE----------PDTEYQFVEQLEERYKCAFCHSVLHN------- ----------PHQTG--------CGHRFCQQCIRSLR-------ELNS--VPICP---VD KEV----------I-KPQE--VFKDNCCKREVLNLHVYCKN-APGCNARIILGRFQ---- -----------------------------------------------DH--L-QHCSFQ- AVPCPNE-----SCREAMLRKD----VKE----HLSAYCRFREEKCLYCKRDIVVTNL-Q --DHE-----------------------------------------------------EN SCPAYPVSCPNRCV--QTIPRARVNEHLT-VCPEA--EQDCPFKHYGCT---V--KGKRG NLLEHERAAL---QDHMLLVL--EKNYQLEQRVSRIIEAL-----------------SRK QTHS--QRLPLTAPKKKKE-HPALRPICSVSGTLVSSGKAL------------TSHTDKS AWLEAQVRQLLQI---VNQQPSRLDLR-SLVDAVDSVKQRITQLEAS------------- --------------DQRLVLLEGE--------------------------TSKH-----D AHINIHKAQLNKNEERFK--Q--LEGACYS-GKLIWKVTDYRVKKREAVEGHT--VSVFS QPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYF-VVMRGEFDSLLQWPFRQR---VTLM LLDQSGK------KNHIVETFKADP---NSSS-FKRP------------DGE--MNIASG CPRFVSHSTLENSKN-TYIKDDTLFLKVAVD-LTDL-----------------------E DL------------------- >M_mulatta_ENSMMUP00000026496 ---------------------------------------------------------MAS SSGSSPRPAPDENEFPF----------GCPPTVCRDPKEPRALC---------------- ----------------------------CTGCLSENL-------RNSE------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DQ ICPKCRGEDLQSVSP-GSRLRTLERAHPE--VAEA--GVGCPFAGVGCS---F--KGSPQ SVQEHEVTSQ---TSHLNLLL--GFMKQWKTRLGSGLESG-----------PMALEQNLS DLQL--QAAVEVAGDLEVD-CYRAPCSESQEELALQHFMKE----------------KLL AELEGKLRVFENI---VAVLNKEVEAS-HLALATSIHQSQLD------------------ --------------RERILSLEQR--------------------------VVEL-----Q QTLAQKDQALGKLEQSLR--L--MEEASFD-GTFLWKITNVTRRCHESACGRT--VSLFS PAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI-VIMRGEYDALLPWPFRNK---VTFM LLDQNNR-------EHAIDAFRPDL---SSAS-FQRP------------QSE--TNVASG CPLFFPLNKLQSPKH-AYVKDDTMFLKCIVE-TST------------------------- --------------------- >M_musculus_ENSMUSP00000028234 ---------------------------------------------------------MAS SS------APDENEFQF----------GCPPAPCQDPSEPRVLC---------------- ----------------------------CTACLSENL-------RDDE------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DR ICPKCRADNLHPVSP-GS-PLTQEKVHSD--VAEA--EIMCPFAGVGCS---F--KGSPQ SMQEHEATSQ---SSHLYLLL--AVLKEWKSSPGSNLGSA-----------PMALERNLS ELQL--QAAVEATGDLEVD-CYRAPCCESQEELALQHLVKE----------------KLL AQLEEKLRVFANI---VAVLNKEVEAS-HLALAASIHQSQLD------------------ --------------REHILSLEQR--------------------------VVEL-----Q QTLAQKDQVLGKLEHSLR--L--MEEASFD-GTFLWKITNVTKRCHESVCGRT--VSLFS PAFYTAKYGYKLCLRLYLNGDGSGK-KTHLSLFI-VIMRGEYDALLPWPFRNK---VTFM LLDQNNR-------EHAIDAFRPDL---SSAS-FQRP------------QSE--TNVASG CPLFFPLSKLQSPKH-AYVKDDTMFLKCIVD-TSA------------------------- --------------------- >C_familiaris_ENSCAFP00000017853 -------------------------------------------------MAYSEDQGGVP CGFIRQNSSNSISLDFE----------PHTEYRFVEPLEERYKCALCHSVLHN------- ----------PHQTG--------CGHRFCQHCILSLR-------ELNA--VPLCP---VD KEV----------I-KSQE--VFKDNCCKREVLNLYVYCKN-APGCNAKIILGRYQ---- -----------------------------------------------QYIWL-QYSTPR- AKVRVNRRSIGTSCKHTMCRGS----EGE----LLSHETALPGSSILLGKQEACILSLSQ --NHE-----------------------------------------------------EN LCPEYPVPCPNKCS--QIIPRTEVDEHLT-VCPEA--EQDCPFKHYGCT---V--KDKRG SLQEHEHSAL---RDHMLLVL--EKNLQLEEQISDLYKSL-----------------EQK ESKI--QQLAETVKKFEKE-FKQFAQLFGKNGSFLSNIQVL------------ANHIDKS AWLEAQVRQLLQM---ANQQQNKFDLR-PLVEAIDTVKQKITLLETN------------- --------------DQRLVVLEGE--------------------------TNKH-----D AHINIHKAQLNKNEERFK--L--LEGACYN-GKLIWKVTDYKMKKREALDGHT--VSIFS QPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYF-VVMRGEFDSLLQWPFRQR---VTLM LLDQSGK------KNHIMETFKADP---SSSS-FKRP------------DGE--MNIASG CPRFVAHSTLENAKN-TYIKDDTVFLKVAVD-LTDL-----------------------E DL------------------- >O_cuniculus_ENSOCUP00000007884 -------------------------------------------------MAYSEEPGGIH LGFIRQNSGSSISLDFE----------PNAEYRFVEQLEERYKCAFCHSVLHN------- ----------PHQTG--------CGHRFCQHCILSLR-------ELNT--VPICP---VD KEV----------I-RSQE--VFKDNCCKREVLNLHVYCKN-APGCNAKVILGRYQ---- -----------------------------------------------EH--L-QQCLFQ- VVQCSHD-----SCQEPVLRRD----LNE----HLSAYCQFREEKCLYCKKDVVVMDL-Q --NHE-----------------------------------------------------EN LCPEYPVSCPNKCL--QIIPRTEVNRHLA-VCPEA--EQDCPFKQYGCT---V--KEKRG SLQEHEHSAL---REHMLLVL--EKNFRLEEQISDLCKSL-----------------EQK ESKI--QQLAETVKKFEKE-FKQFAQLFGKNGSFLSNIQXX------------XXXXXXX XXXXXXXXXXXXX---XXXXXXXXXXX-XXXXXXXXXXXXXXXXXXX------------- --------------XXXXXVLEGE--------------------------TSKH-----D AHINIHKAQLNKNEERFK--L--LEGACYN-GKLIWKVTDYKMKKKEAVDGHT--VSIFS QPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYF-VVMRGEFDSLLQWPFRQR---VTLM LLDQSGK------RNHIMETFKADP---NSSS-FKRP------------DGE--MNIASG CPRFVAHSTLENAKN-TYIKEDTLFLKVAVD-LTDL-----------------------E DL------------------- >P_pygmaeus_ENSPPYP00000021917 ---------------------------------------------------------MAS SSGSSPRPAPDENEFPF----------GCPPTVCQDPKEPRALC---------------- ----------------------------CTGCLSENP-------RNGE------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DQ ICSKCRGEDLQSISP-GSRLRTQEKAHPE--VAEA--GVGCPFAGVGCS---F--KGSPQ SVQEHEVTSQ---TSHLNLLL--GFMKQWKARLGCGLESG-----------PMALEQNLS DLQL--QAAVEVAGDLEVD-CYRAPCSESQEELALQHFMKE----------------KLL AELEGKLRVFENI---VAVLNKEVEAS-HLALATSIHQSQLD------------------ --------------RERILSLEQR--------------------------VVEL-----Q QTLAQKDQALGKLEQSLR--L--MEEASFD-GTFLWKITNVTRRCHESACGRT--VSLFS PAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI-VLMRGEYDALLPWPFRNK---VTFM LLDQNNR-------EHAIDAFRPDL---SSAS-FQRP------------QSE--TNVASG CPLFFPLSKLQSPKH-AYVKDDTMFLKCIVE-TST------------------------- --------------------- >E_caballus_ENSECAP00000009372 ---------------------------------------------------------MAS GSASSPRPAPDENEFPF----------GCPPTVCEDPSEPRALC---------------- ----------------------------CAACLSENS-------RNGE------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DR VCLKCRGDDSQSVGP-GS-LVSQEKVHSD-AVAEA--GVGCPFAGVGCS---F--KGSPK FMQEHEVASQ---ATHLNLVL--GFMKQWKAQLGSGLGSG-----------PMALEQNLS DLQL--QAAVEVAGDLEVD-CYRAPCSESQEELALQHFMKE----------------KLL AELEGKLRVFENI---VAVLNKEVEAS-HLALAASIHQSQLD------------------ --------------REHILSLEQR--------------------------VLEL-----Q QTLAQKDQALGKLEQSLR--L--MEEASFD-GTFLWKITNVTRRCHESACGRT--VSLFS PAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI-VIMRGEYDALLPWPFRNK---VTFM LIDQNNR-------EHAIDAFRPDL---NSAS-FQRP------------QSE--TNVASG CPLFFPLSRLQSPKH-AYVKDDTMFLKCIVE-TSA------------------------- --------------------- >M_mulatta_ENSMMUP00000015419 -----------------------MESSKKMDSPGPLQTNPPLK----------------- -LHTDRSAGTPIFAPEQ----------GGYKEKFVKTVEDKYKCEKCRLVLCS------- ----------PKQTE--------CGHRFCESCMAALL-------SSSS---PKCT---AC QES----------V-VRDK--VFKDNCCKREILALQIYCRNESRGCAEQLTLGHLL---- -----------------------------------------------VH--LKNDCHFE- ELPCVRA-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMIAL-Q --KHE-----------------------------------------------------DT DCPCVVVSCPHKCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F--QGTNQ QIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-----------------VEK NKSI--QSLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKSAGQV------ --------------ARNTGLLESQ--------------------------LSRH-----D QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYS QPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM LMDQGSS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASG CPVFVAQTVLENG---TYIK---------------------------------------- --------------------- >O_cuniculus_ENSOCUP00000004916 ---------------------------------------------------------MAS SSASSPRPAPDENEFPF----------GCPPSAFQDPAEPRALC---------------- ----------------------------CTACLSE-L-------RNCE------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DR ICPACKGDNPTSVSP-GS-LRTQEKXXXX--XXXX--XXXXXXXXXXXX---X--XGNAQ SLQEHEATSQ---ASHLNLLL--GFMKQWKAQLGSGLGSG-----------PMALERNLS DLQL--QAAVEVAGDLEVD-CYRAPCSESQEELALQHLMKE----------------KLL AELEGKLRVFENI---VAVLNKEVEAS-HLALAASIHQSQLD------------------ --------------RERILSLEQR--------------------------VVEL-----Q QTLAQKDQALGKLEQSLR--L--MEEASFD-GTFLWKITNVTRRCLESACGRT--VSLFS PAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI-VIMRGEYDALLPWPFRNK---VTFM LLDQNNR-------EHAIDAFRPDL---SSAS-FQRP------------QSE--TNVASG CPLFFPLNKLQSPKH-AYVKDDTMFLKCIVE-TSA------------------------- --------------------- >B_taurus_ENSBTAP00000041215 ---------------------------------------------------------MAS GSASSPRPAPDENEFPF----------GCPPTACQDPPEPGPVC---------------- ----------------------------CAVCLSEKV-------RNDE------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DR ICPKCKGDDTPSESP-GS-LLSQEKDHPE--VAEA--GVGCPFAGVGCS---F--KGSPK FMEEHEVTSQ---AAHLNLLL--GFMKQWKAQLGSGLGYG-----------PMALERNLS DLQL--QGAVEVAGDLEVD-CYRAPCSESQDELALHHFMKE----------------KLL NELEGKLCVFENI---VAVLNKEVEAS-HLALAASIHQSQLD------------------ --------------REHILSLEQR--------------------------VLEL-----Q QTLAQKDQALGKLEQSLR--L--VEEASYD-GTFLWKITNVTRRCHESACGRT--VSLFS PAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI-VIMRGEYDALLPWPKKGE---VTFM LLDQNNR-------EHAIDAFRPDL---NSAS-FQRP------------QSE--TNVASG CPLFFPLNKLQSPKH-AYVKDDTMFVKCVVD-TNT------------------------- --------------------- >G_gorilla_ENSGGOP00000002249 ---------------------------------------------------------MAS SSGSSPRPAPDENEFPF----------GCPPTVCQDPKEPRALC---------------- ----------------------------CAGCLSENP-------RNGE------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DQ ICPKCRGEDLQSISP-GSRLRTQEKAHPE--VAEA--GVGCPFAGVGCS---F--KXXXX XXXXXXXXXX---XXXXXXXX--XXXXXXXXXXXXXXXXX-----------XXXXXXXXX XXXX--XXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXX----------------XXX XXXXXXXXVFENI---VAVLNKEVEAS-HLALATSIHQSQLD------------------ --------------RERILSLEQR--------------------------VVEL-----Q QTLAQKDQALGKLEQSLR--L--MEEASFD-GTFLWKITNVTRRCHESACGRT--VSLFS PAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI-VIMRGEYDALLPWPFRNK---VTFM LLDQNNR-------EHAIDAFRPDL---SSAS-FQRP------------QSE--TNVASG CPLFFPLSKLQSPKH-AYVKDDTMFLKCIVE-TST------------------------- --------------------- >X_tropicalis_ENSXETP00000031605 -------------------------------------------------IMACEDLCPLP VTLGRQNSSAAVSLDFV----------PKQEYLFVEQLQDRYKCASCHLVLHN------- ----------PHQTG--------CGHRFCEKCISNLI-------ELSE--TPQCP---ID MEN----------I-KSHE--IFKDNCCKREVLNLLVYCKN-SPACDVKVMLGRYQ---- -----------------------------------------------EH--L-GQCLYE- MTLCSND-----GCHDQMIRKE----LKG----HLESECKLRQEACIYCKQTMASINL-T --IHV-----------------------------------------------------GL YCQLYPVPCPNACP--VTCPRAELDKHLC-ECPEA--ELQCTFSNYGCN---V--MVKRG KVKEHEDTFL---RDHMLYVL--NRNMKLEEQVLGLQQNL-----------------DLK EHQI--QQLSDTVKWCEKE-CHQFGQFTGSNGNSLSSTKTL------------ASYIDKS MWLEEQV---IQL---VSKEHSRLDLR-PILDTLESTKQRLSTLEAY------------- --------------KDRIDNLDGQ--------------------------FKKH-----D VLLSNHKMQMTSNEERFR--L--VEGTSYN-GKLIWKITDYERKKREAMEGRA--VSIFS QHFYTSWCGYRLCARAYLNGDGSGK-GSFLSLYF-VVMKGEFDSILLWPFKQK---VTLM LLDQSGK------KNHITDVFRADP---NSSS-FKRP------------DSE--MNIASG CPRFASHAQLENPKNGCYIK---------------------------------------- --------------------- >C_intestinalis_ENSCINP00000001022 -----------------------MDTAD-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S --RHQ-----------------------------------------------------SG ENSSFASSQPES-------VDQIPQNHLN-ESPYV--LNNEALSLESSL---T--TGDLN SVKAQCEYSH---KILQRQLQ--EMKNAVE-----LEMRK-----------------RES DRDG--NVLRANITKLEQR-LTALQRMTAQQTDRSLALKKEVGDNDAANKRANTDLTQKV EEIAREIAQIKEK---QNELE-------R-------------KIESTSSSR--E------ --------------QMAPENLSQM--------------------------VDAF-----E RQLGMYDVRIADMDQRFQ--V--LETTSYS-GVVIWKIRDFSRRKREAVSGRT--LSLYS QPFYTSRYGYKMCARVYLNGDGMGK-GTHMSLFF-VVMKGEYDALLPWPFRQK---VTLM LLDQGMD------RRHLSDTFRPDP---TSSS-FKKP------------TSD--MNIASG CPLFVAHNVIEGS---SYVKEDTIFLRIHVD-TSDL-----------------------E NF------------------- >C_intestinalis_ENSCINP00000027890 -----------------------M------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----L-----------------------------------------------------ST ENVS-PSLQRSS-------V---FNSWTS-KSPID--FSISEPSFNFNG---L--SHPEV GISDYCKSEH---DALRSHLA--EISQTL-----------------------------NN LKNS--NDVSPEIRKLEVR-LKAIQRMTAQQTDRSLALKKEVGDNDAANKRANTDLTQKV EEIAREIAQIKEK---QNELE-------R-------------NIESTSGSR--E------ --------------QMAPENLSQM--------------------------VDAF-----E RQLGMYDVRIADMDQRFQ--V--IETTSYS-GVVIWKIRDFSRRKREAVSGRT--LSLYS QPFYTSRYGYKMCARVYLNGDGMGK-GTHMSLFF-VVMKGEYDALLPWPFRQK---VTLM LLDQGMD------RRHLSDTFRPDP---TSSS-FKKP------------TSD--MNIASG CPLFVAHNVIEDS---SYVKEDTIFLRIHVD-TSDL-----------------------E NF------------------- >C_intestinalis_ENSCINP00000001432 -----------------------M------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------YSH---KILQRQLQ--EMKNAVE-----LEMRK-----------------RES DRDG--NVLRANITKLEQR-LTALQRMTAQQTDRSLALKKEVGDNDAANKRANTELTQKV EEIGREIAQIKEK---QNELK-------R-------------KLESTSSSR--E------ --------------QIAPENLSQM--------------------------VDAF-----E LQLGMYDVRIADMDQRFQ--V--IETTSYS-GFLIWKIRDFSRRKREAVSGRT--LSLYS QPFYTSRYGYKMCARVYLNGDGMGK-GTHMSLFF-VVMKGEYDALLPWPFRQK---VTLM LLDQGMD------RRHLSDTFRPDP---TSSS-FKKP------------TSD--MNIASG CPLFVAHNVIEDS---SYVKEDTIFLRIHVD-TSDL-----------------------E NF------------------- >C_intestinalis_ENSCINP00000003143 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MAPENLSQM--------------------------VDAF-----E RQLGMYDVRIADMDQRFQ--V--IETTSYS-GVVIWKIRDFSRRKREAVSGRT--LSLYS QPFYTSRYGYKMCARVYLNGDGMGK-GTHMSLFF-VVMKGEYDALLPWPFRQK---VTLM LLDQGMD------RRHLSDTFRPDP---TSSS-FKKP------------TSD--MNIASG CPLFVAHNVIEDS---SYVKEDTIFLRIHVD-TSDL-----------------------E NF------------------- >O_latipes_ENSORLP00000001368 ------------------------------------------------------------ ---------LAGRLQTH----------GVVRNHFVMKLKEEFICPICKGVVLN------- ----------PQQNS--------CGHIYCFHCLQGLL-------ESSLLSGPVCP---VE KAA----------I-TPSE--VFQDNCCKREISSLEVYCTN-SPLCTSVLALNQLQ---- -----------------------------------------------EH--L-KSCQYE- QLLCSNP-----GCTELLQRRL----LQE----HLNATCPHRRESCPHCLQPFQLSVI-Q --DHV-----------------------------------------------------QS SCPKVKGGCPDGCS--TLVPKNRLTEHGE-SCPEV--HTDCSFKMFGCS---V--KGKRR KVKLHEEAAV---CHHVLLVL--KSSAHLEQQVVFVQKEA-----------------LLR QQEV--QTDTLLLSDLQEQ-LGSVLQQSRSQEHIVATAQAC-----------LDEHRADI LEMENELLAAETL---REHIGNQTGNSRSVKLRSATLCTGVFLFYIKC------------ --------------HLMSATLEEN--------------------------RKRH-----S GLLELHVAQLALNKQHLQ--E--LELTSYD-GRLIWKIKDFQKRREAEATGQH--PCLSS VPFHTGRCGYKMAMKAYLNGDGEGR-GTHLSLYV-VLMPGDFDALLPWPFKQT---VSLS VLDQSGA------RNHQSFNFRPDP---TNTC-FHQP------------AAESASNVAVG FPCFISLDALEAPGNAVYVKDDTLFVKVKVD-TTGL-----------------------E --------------------- >C_intestinalis_ENSCINP00000005981 -----------------------M------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------IPELNQKL KEMIEEMTRIRQK---QNELE-------R-------------KL----STR--N------ --------------QENEQNFLAQ--------------------------INGF-----E QQIGLYDVRIADMDQRFQ--V--LETTSYS-GVALWKINNFQPRKREAESGRA--LSIYS QPFYTSRYGYKMCARVYLNGDGMGK-GTHVSLFF-VLMKGEYDNLLPWPFRQK---VTLM LLDQGLE------RRHLSDMFRPDP---TSSS-FTKP------------TSD--MNIASG CPLFVAHNLIEGS---SYVKDDVIFIRIHVD-TTDL-----------------------E TF------------------- >G_gorilla_ENSGGOP00000004192 -----------------------MESSKKMDSPGALQTNPPLK----------------- -LHTDRSAGTPVFVPEQ----------GGYKEKXXXXXXXXXXXXXXXXXXXX------- ----------XXXXX--------XXXXXXXXXXXXXX-------XXXX---XXXX---XX XXS----------I-VKDK--VFKDNCCKREILALQIYCRNESRGCAEQLTLGHLL---- -----------------------------------------------XX--XXXXXXXX- XXXXXXX-----XXXXXXXXXX----XXX----XXXXXXXXXXXXXXXXXXXXXXXXX-X --KHE-----------------------------------------------------DT DCPCVVVSCPHKCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F--QGTNQ QIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-----------------VEK NKSI--QSLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKSAGQV------ --------------ARNTGLLESQ--------------------------LSRH-----D QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYS QPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM LMDQGSS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASG CPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P DP------------------- >C_familiaris_ENSCAFP00000031262 ---------------------------------------------------------MAS GSASSPRPAPDENEFPF----------GCPPDACQEPAEPRAVR---------------- ----------------------------CAACLPENV-------RSGE------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DR ICPKCQGDDPQSGSP-GS-PLSQEKDPPE--VAEA--EVGCPFAGVGCP---Y--KGSPR LMQEHEVASQ---TTHLNLLL--GCVTPWMAPRGP--GGA-----------ALALERNLS DLQL--QAAVEVAGDLEVD-CYRAPRSDSQDEHTLQRLTKE----------------KPL AELQEKLRVFENI---VAVLNKEVEAS-HLALAASIHQSQLD------------------ --------------REHILSLEQQ--------------------------VAKA-----L HLCAVKAQWSVLPLLSHR--E--QEDHSFVWARSWWKITNVTFRCHESACGRT--VSLFS PAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI-VIMRGEYDALLPWPFRNK---VTFM LLDQNNR-------EHAIDAFRPDL---SSAS-FQRP------------QSE--TNVASG CPLFFPLSRLQSPKH-AYVKDDTMFLKCIVE-TNA------------------------- --------------------- >O_cuniculus_ENSOCUP00000003184 ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------SSS---PKCT---AC QES----------I-VKDK--VFKDNCCKREILALQICCRNESRGCAEQLALGHLL---- -----------------------------------------------VH--LKNDCQFE- ELACVRA-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMITL-Q --XXX-----------------------------------------------------XX XXXXXXXXXXXXXXX-XXXXXXXLSAHLS-ECVNA--PSTCSFKRYGCV---F--QGTNQ QIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-----------------VEK NKSI--QSLHNQICSFEIE-IERQKEMLRNNESKILHLQXX-----------XXXXXXXX XXXXXXXXXXXXX---XXXXX-------XXXXXXXXXXXXXXXXXXXXXXXXXX------ --------------XXXXXLLESQ--------------------------LSRH-----D QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYS QPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM LMDQGSS------RRHLGDAFKPDP---NSSS-FRKP------------TGE--MNIASG CPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P DP------------------- >A_carolinensis_ENSACAP00000017068 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------VEQQ-----D SLLAVKDVMISNLASRIH--T--LEQTTYD-GCLLWKIPEVGLRSREARTGNR--PACYS PAFYTSRYGYKVCLKVFLNGEGTGT-GTHLSLFL-VLMKGEYDFQLKWPFRHK---VTFT LLDQDNK-------QHISTSFRPLE---SSSS-FQRP------------VNE--TNVASG LPEFCPLNVLHSPRT-SYICNDTLAIQAVID-M--------------------------- --------------------- >M_domestica_ENSMODP00000024090 ------------------------------------------------------------ --------------------------MPGFDYKFLEKPKRRLLCPLCAKAMRE------- ----------PVQVST-------CGHRFCDTCLQEFL-------SEGV---FKCP---ED QLP----------L-DYAK--IYPDPELEAQVLSLPIRCIHSEEGCRWTGALRQLQ---- -----------------------------------------------VH--L-SSCGYN- VVACPN------RCNGKLSRRD----LPS----HLQHECPKRRLKCDFCGIDFTGEAF-E --SHEGVCPQESVYCENKCGARMMRRLLGQHMMAECPKRTQPCAYCTKEFVYDTIQNHQH QCPRYPIPCPNQCGM-GSIPREDLNSHLKENCSTV--PVLCPFKDAGCK---H--RCPKL AMGRHMEESV---KPHLAMMC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ALVSRQRQELQELRRDVE-----ELSVGCD-GVLIWKIGGYGRRLQEAKARAN--HECFS PAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI-RVLPGAFDNLLEWPFARR---VTFS LLDQSDP--AVAKPQHVTETFHPDP---HWKN-FQKP-----GTWRGS-MDE--SALGFG YPKFISHQDIRKR---NYVRDDAVFIRASVELPKKILS---------------------- --------------------- >D_rerio_ENSDARP00000013849 ------------------------------------------------------------ --------------------------MPGFDYKFLEKPKRRFQCPLCSKAMRE------- ----------PVQVST-------CGHRFCDTCLQEFL-------SEGV---FKCP---ED QLP----------L-DYAK--IYPDPELEQQILALPIRCIHSEEGCRWTGQMKQLQ---- -----------------------------------------------SH--F-STCAFN- VIPCPN------RCSVKLTRRD----LPE----HLQHDCPKRKVKCEFCGSEFTGEAY-E --NHQGICPQESVYCENKCGARMMRRLLSQHTMTECPKRTQPCKYCGKEFVYDTIQNHQY HCPRFPVQCPNQCGT-PNIAREDLANHVKESCGSA--LVLCPFKEAGCK---H--RCPKM AIGRHLEEST---KSHLTMMC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ SLVGRQRQEILELRREME-----ELSVSHD-GVLIWKLTDYSRKLQEAKLRNN--HEFFS PPFYTHRYGYKLQVSAFLNGNGSGE-GSHLSIYI-RVLPGEYDNLLEWPFSYK---VTFS ILDQSDP--SLSKPQHITETFNPDP---NWKN-FQKP-----CSSRNS-LDE--STLGFG YPKFISHEEIKKR---NYIRDNSIFLKASIEIPQKIMA---------------------- --------------------- >H_sapiens_ENSP00000262395 ------------------------------------------------------------ --------------------------MPGFDYKFLEKPKRRLLCPLCGKPMRE------- ----------PVQVST-------CGHRFCDTCLQEFL-------SEGV---FKCP---ED QLP----------L-DYAK--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ---- -----------------------------------------------GH--L-NTCSFN- VIPCPN------RCPMKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E --SHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQY QCPRLPVACPNQCGV-GTVAREDLPGHLKDSCNTA--LVLCPFKDSGCK---H--RCPKL AMARHVEESV---KPHLAMMC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ALVSRQRQELQELRRELE-----ELSVGSD-GVLIWKIGSYGRRLQEAKAKPN--LECFS PAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI-RVLPGAFDNLLEWPFARR---VTFS LLDQSDP--GLAKPQHVTETFHPDP---NWKN-FQKP-----GTWRGS-LDE--SSLGFG YPKFISHQDIRKR---NYVRDDAVFIRAAVELPRKILS---------------------- --------------------- >G_aculeatus_ENSGACP00000014759 ------------------------------------------------------------ --------------------------MPGFDYKFLEKPKRRFQCPLCSKAMRE------- ----------PVQVST-------CGHRFCDTCLQEFL-------SEGV---FKCP---ED QLP----------L-DYAK--IYPDPELEQQILALPIRCIHSEEGCRWTGQMKQLQ---- -----------------------------------------------GH--F-STCAFN- VIPCPN------RCSVKLTRRD----LPD----HLQHDCPKRKVKCEFCGSEFTGEAY-E --NHQGVCPQESVYCENKCGARMMRRLLSQHGLAECPKRTQPCKYCGKEFVFDTIQNHQY HCPRFPVQCPNQCGT-PNIAREDLANHVKDNCGSA--LVLCPFKDAGCK---H--RCPKL AIGRHLEDTT---KSHLTMMC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ NLVGRQRQEILELRREME-----ELSVSHD-GVLIWKLSDYSRKLQEAKLRSN--HEFFS PPFYTHRYGYKLQVSAFLNGNGSGE-GSHLSVYI-RVLPGEYDSLLEWPFSYK---VTFS ILDQSDP--SLSKPQHITETFNPDP---NWKN-FQKP-----SSSRNS-LDE--STLGFG YPKFISHDEIKKR---NYIRDNCVFIKASIEIPQKIMT---------------------- --------------------- >B_taurus_ENSBTAP00000050075 ------------------------------------------------------------ --------------------------MPGFDYKFLEKPKRRLLCPLCGKPMRE------- ----------PVQVST-------CGHRFCDTCLQEFL-------SEGV---FKCP---ED QLP----------L-DYAK--IYPDPELEVQVLGLSIRCIHSEEGCRWNGPLRHLQ---- -----------------------------------------------GH--L-NTCSFN- VVPCPN------RCPAKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAF-E --SHEGVCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQY QCPRLPVPCPNQCGV-GTVAREDLPGHLKDSCSTA--LVLCPFKDSGCK---H--RCPKL AMARHVEESV---KPHLAMMC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ALVSRQRQELQELRRELE-----ELSVGSD-GVLIWKIGSYGRRLQEAKAKPN--LECFS PAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI-RVLPGAFDNLLEWPFARR---VTFS LLDQSDP--GLAKPQHVTETFHPDP---NWKN-FQKP-----GTWRGS-LDE--SSLGFG YPKFISHQDIRKR---NYVRDDAVFIRASVELPRKILS---------------------- --------------------- >M_musculus_ENSMUSP00000017530 ------------------------------------------------------------ --------------------------MPGFDYKFLEKPKRRLLCPLCGKPMRE------- ----------PVQVST-------CGHRFCDTCLQEFL-------SEGV---FKCP---ED QLP----------L-DYAK--IYPDPELEVQVLGLAIRCIHSEEGCRWSGPLRHLQ---- -----------------------------------------------GH--L-NTCSFN- VVPCPN------RCPAKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E --SHEGVCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCAYCTKEFVYDTIQSHQY QCPRLPVPCPNQCGV-GTVAREDLPTHLKDSCSTA--FVLCPFKESGCK---H--RCPKL AMGRHVEESV---KPHLAMMC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ALVSRQRQELQELRRELE-----ELSIGSD-GVLIWKIGSYGRRLQEAKAKPN--LECFS PAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSIYI-RVLPGAFDNLLEWPFARR---VTFS LLDQSDP--GLAKPQHVTETFHPDP---NWKN-FQKP-----GTWRGS-LDE--SSLGFG YPKFISHQDIRKR---NYVRDDAVFIRASVELPRKILS---------------------- --------------------- >R_norvegicus_ENSRNOP00000018468 ------------------------------------------------------------ --------------------------MPGFDYKFLEKPKRRLLCPLCGKPMRE------- ----------PVQVST-------CGHRFCDTCLQEFL-------SEGV---FKCP---ED QLP----------L-DYAK--IYPDPELEVQVLGLAIRCIHSEEGCRWSGPLRHLQ---- -----------------------------------------------GH--L-NTCSFN- VVPCPN------RCPAKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E --SHEGVCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCAYCTKEFVYDTIQSHQY QCPRLPVPCPNQCGV-GTVAREDLPTHLKDSCSTA--FVLCPFKESGCK---H--RCPKL AMGRHVEESV---KPHLAMMC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ALVSRQRQELQELRRELE-----ELSVGSD-GVLIWKIGSYGRRLQEAKAKPN--LECFS PAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSIYI-RVLPGAFDNLLEWPFARR---VTFS LLDQSDP--GLAKPQHVTETFHPDP---NWKN-FQKP-----GTWRGS-LDE--SSLGFG YPKFISHQDIRKR---NYVRDDAVFIRASVELPRKILS---------------------- --------------------- >G_gallus_ENSGALP00000012873 ----------------MSLLHSDSSCGGRDLDSGCCTAM-ASACSGGAKED--S---VSV GS--GTGNPPSSFTEET----------QGYDVEFDPPLESKYECPICLMALRE------- ----------AVQTP--------CGHRFCKGCIVKSIRRC----RDAG---HKCP---VD NEI----------L-LENQ--LFPDNFAKREILSLTVKCPNK--GCCLKMELRHLE---- -----------------------------------------------EH--Q-LHCDFT- TVECPQ-------CQGAFQKNH----LKE----HMTQECPRRQVCCPNCATSMAYEDK-E --LHD------------------------------------------------------Q TCPLANVFCEYCN---TMLIRQQMPNHYDNDCPTA--PVPCFYSAFGCP---E--KMQRN ELARHMQEFT---QVHMRMMA--QSIQNISVTATNP---V----------------P--- FING--LPFEPALFS---------------HVSRAPYN--C---------------NPEV ENFKETIQQLEGR---LVRQDHQ------------------------------------- -----------------IRELIAK--------------------------METQ-----N THMAELKRTIRDLEGKIT--E--MEAQQCN-GIYIWKIENFSGLQKAQEEERP--VVMHS PGFYTGKPGYKLCLRLHIQLPSAQRCANFISLFV-HTMQGEYDSHLPWPFQGT---IRLS ILDQSEG----PERQNHEEVMEAKP---ELLA-FQRP------------TIHR-NPKGFG YVTFMHLQTLKQR---TFVKDDTLLVRCEVLTRLDL-----------------------N SLRREG--FQARSTDGAA--- >R_norvegicus_ENSRNOP00000006148 ----------------MSLLNCENSCASSQSSSDCCAAM-ANSCSAAMKDD--S---VSG CV--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALRE------- ----------AVQTP--------CGHRFCKACITKSI-------RDAG---HKCP---VD NEI----------L-LENQ--LFPDNFAKREILSLTVKCPNK--GCVQKMELRHLE---- -----------------------------------------------DH--Q-VHCEFA- LVICPQ-------CQRFFQKCQ----INK----HIIEDCPRRQVSCVNCAVPMPYEEK-E --IHD------------------------------------------------------Q SCPLANIICEYCG---TILIREQMPNHYDLDCPTA--PVPCTFSVFGCH---E--KMQRN HLARHLQENT---QLHMRLLA--QAVHNVNL-SLRP---C-------------------- ------------------------------DASSPSRG--C---------------RPED PNYEETVKQLEGR---LVRQDHQ------------------------------------- -----------------IRELTAK--------------------------METQ-----S MHVSELKRTIRSLEDKVA--E--MEAQQCN-GIYIWKIGNFGMHLKSQEEERP--VVIHS PGFYTGRPGYKLCMRLHLQLPTAQRCANYISLFV-HTMQGEYDSHLPWPFQGT---IRLT ILDQSEA----VIRQNHEEVMDAKP---ELLA-FQRP------------TIPR-NPKGFG YVTFMHLEALRQG---TFIKDDTLLVRCEVSTRFDM-----------------------G GLRKEG--FQPRSTDAGV--- >O_latipes_ENSORLP00000005579 ------------------------------------------------------------ --------------------------MPGFDYKFLEKPKRRFQCPLCSKAMRE------- ----------PVQVST-------CGHRFCDTCLQEFL-------SEGV---FKCP---ED QLP----------L-DYAK--IYPDPELEQQILSLPIRCIHSEEGCRWTGQMKQLQ---- -----------------------------------------------GH--F-STCAFN- VIPCPN------RCSVKLTRRD----LPD----HLQHDCPKRKVKCEFCGSEFTGEAF-E --NHQGVCPQESVYCENKCGARMMRRLLSQHGMAECPKRTQPCKYCGKEFVFDTIQNHQF HCPRFPVQCPNQCGT-PNIAREDLANHVKDNCGSA--LVLCPFKDAGCK---H--RCPKL AIGRHLEDTT---KSHLTMMC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ NLVSRQRQEILELRREME-----ELSVSHD-GVLIWKLNDYSRKLQEAKLRSN--HEFFS PPFYTHRYGYKLQVSAFLNGNGSGE-GSHLSVYI-RVLPGEYDNLLEWPFSYK---VTFS ILDQSDP--SLSKPQHITETFNPDP---NWKN-FQKP-----CSTRNS-LDE--STLGFG YPKFISHEEIKKR---NYIRDNCIFIKASIEIPQKIMG---------------------- --------------------- >D_rerio_ENSDARP00000014326 ------------------------------------------------------------ -------------------------------------LEQQFICPSCGGIVLN------- ----------PHQTG--------CGHIFCAQCVKAYT-------ENGG--SSKCP---LD SIP----------I-KPEE--IFQDNCCKRELLNLEVFCTN-APECTQRFSLCNLQ---- -----------------------------------------------DH--L-KACPHE- RVRCSHS-----DCSDIVLRKN----LLE----HQRNACSYRLETCHYCRQNFPVSQMMQ --GHQ-----------------------------------------------------KS SCPDVEVPCSNNCT--QMIKRHQLQAHAD-ECLEV--ETDCVYKNYGCT---V--RDKRG KVQVHENTEF---SAHVRLVL--EKLCEQTLCSLTMQSRV-------------------- ------STFSCDRRSVEEQ-------------------------------------RVRI CSVQRELRDLRVL---GSELKEELPRL--------------------------------- --------------QASLDSLRQQ-----------------------------------V AVTESLREHLVALKQHST--F--LESSSYD-GKLIWKVRDYWHRKESG-------AALSS SPFYTSRSGYKLSVRAYLGGDGSGR-GSHMSLYI-TIMRGDFDSFLPWPFRQN---ITLT LLDQSGT------RNHMSHTFIPDV---NSDS-FHRP------------TSD--ANVATG FTRFISHCDLENPRNAVFVRDETLFIKVKV------------------------------ --------------------- >T_guttata_ENSTGUP00000010462 ----------------MSLLHSDSSCGGRDAESGCCAAM-ASACSAAAKEE--S---SSV GS--AVGTAPGSFGEET----------QGYDVEFDPPLESKYECPICLMALRE------- ----------AVQTP--------CGHRFCKGCIVKSI-------RDAG---HKCP---VD NEI----------L-LENQ--LFPDNFAKREILSLMVKCPNK--GCSMKMELRHLE---- -----------------------------------------------DH--Q-LQCDFS- TVECLQ-------CQGTFPKNH----LKE----HMTQECPRRQVCCPNCATSMAYEDK-E --LHD------------------------------------------------------Q TCPLANIYCEYCN---TVLIREQMPNHYDNDCPTA--PVPCFYSAFGCP---E--KMQRN ELARHMQEFT---QVHMRMMA--QSFQNISVTAANP---V----------------P--- FING--LPFEPALFS---------------HVSHAAYN--C---------------NPEV ENFKETIQQLEGR---LVRQDHQ------------------------------------- -----------------IRELIAK--------------------------METQ-----N THMAELKRTIRNLEGKIT--E--MEAQQCN-GIYIWKIENFSGLQRAQEEERP--VVLHS PGFYTGKPGYKLCLRLHIQLPNAQRCANFISLFV-HTMQGEYDSHLPWPFQGT---IRLS ILDQSEG----PERQNHEEVMEAKP---ELLA-FQRP------------TIHR-NPKGFG YVTFMHLETLKQR---TFIKDDTLLVRCEVLTRLDL-----------------------S SVRREG--FQPRSTDGAM--- >T_rubripes_ENSTRUP00000012878 ------------------------------------------------------------ --------------------------MPGFDYKFLEKPKRRFQCPLCSKAMRE------- ----------PVQVST-------CGHRFCDTCLQEFL-------SEGV---FKCP---ED QLP----------L-DYAK--IYPDPELEQQILALAIRCIHSEEGCRWTGQMKQLQ---- -----------------------------------------------GH--F-STCAFN- VIPCPN------RCSVKLTRRD----LPD----HLQHDCPKRKVKCEFCGSEFTGEAY-E --NHQGVCPQESVYCENKCGARMMRRLLSQHGMAECPKRTQPCKYCSKEFVFDTIQNHQY HCPRFPVQCPNQCGT-PNIAREDLANHVKDNCGSA--LVLCPFKDAGCK---H--RCPKL AIGRHLEDTT---KSHLTMMC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ NLVGRQRQEILELRREME-----ELSVGHD-GILIWKLNDYSRKLQEAKIRSN--HEFFS PPFYTHRYGYKLQVSAFLNGNGSGE-GSHLSVYI-RVLPGEYDNLLEWPFSYK---VTFS LLDQSDP--SLSKPQHITETFNPDP---NWKN-FQKP-----SSTRNS-LDE--STLGFG YPKFISHEEIKKR---NYVRDNCIFIKASIEIPQKIMA---------------------- --------------------- >M_musculus_ENSMUSP00000004949 ----------------MSLLNCENSCGSSQSSSDCCAAM-AASCSAAVKDD--S---VSG SA--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALRE------- ----------AVQTP--------CGHRFCKACIIKSI-------RDAG---HKCP---VD NEI----------L-LENQ--LFPDNFAKREILSLTVKCPNK--GCLQKMELRHLE---- -----------------------------------------------DH--Q-VHCEFA- LVNCPQ-------CQRPFQKCQ----VNT----HIIEDCPRRQVSCVNCAVSMAYEEK-E --IHD------------------------------------------------------Q SCPLANIICEYCG---TILIREQMPNHYDLDCPTA--PIPCTFSVFGCH---E--KMQRN HLARHLQENT---QLHMRLLA--QAVHNVNL-ALRP---C-------------------- ------------------------------DAASPSRG--C---------------RPED PNYEETIKQLESR---LVRQDHQ------------------------------------- -----------------IRELTAK--------------------------METQ-----S MYVGELKRTIRTLEDKVA--E--MEAQQCN-GIYIWKIGNFGMHLKSQEEERP--VVIHS PGFYTGRPGYKLCMRLHLQLPTAQRCANYISLFV-HTMQGEYDSHLPWPFQGT---IRLT ILDQSEA----LIRQNHEEVMDAKP---ELLA-FQRP------------TIPR-NPKGFG YVTFMHLEALRQG---TFIKDDTLLVRCEVSTRFDM-----------------------G GLRKEG--FQPRSTDAGV--- >A_carolinensis_ENSACAP00000005007 ----------------MSLLHSNTSFETNSQESGCCAAM-ASACSAAAKEE--SINASVS NE--TGGTLSNSFMEET----------QGYDVEFDPPLESKYECPICLMALRE------- ----------AVQTP--------CGHRFCKACIVKSI-------RDAG---HKCP---ID NEI----------L-LETQ--LFPDNFAKREILSLTVKCPNK--GCDQKMELRHLE---- -----------------------------------------------DH--Q-QHCGFA- SEKCPQ-------CQGIFQKNR----LQE----HIKLECPRRQVSCPNCALLMPYEDK-E --VHD------------------------------------------------------G VCLLANVCCEYCN---TVLIREQLPNHYDNDCPTA--PVPCTYSDFGCP---E--KMQRN ELARHWQEFT---QVHMRMMA--QTLRNVHVTNPAS------------------------ ------GNF---------------------HAMPPSCE--C---------------SPEV RNFKETIQQLEGR---LVRQDHQ------------------------------------- -----------------IRELIAK--------------------------METQ-----N SQVGDLKGTIKNLEEKIT--E--LEAQQCN-GIFIWKIEHFSVYLKALEEERP--VVIHS PGFYTGKPGYKLCMRLHIQLPNVQRCANYISLFV-HIMQGEYDNYLPWPFQGT---IRLS VLDQSEG----SPRQNHEEVMDTKP---ELLA-FQRP------------KTRR-NPKGFG YVTFMQLQTLRQR---TYIKEDTVLVRCEVLTRLDV-----------------------M SPRREG--FQPRSTDGTV--- >M_mulatta_ENSMMUP00000021907 MYILKERIRASDNQVTMSLLNCENSCGSSQSESDCCVAM-ASSCSAATKDD--S---VGG TA--STGNLSSSFMEDI----------QGYDVEFDPPLESKYECPICLMALRE------- ----------AVQTP--------CGHRFCKACIIKSI-------RDAG---HKCP---VD NEI----------L-LENQ--LFPDNFAKREILSLMVKCPNE--GCLHKMELRHLE---- -----------------------------------------------DH--Q-AHCEFA- LVDCPQ-------CQRPFQKFH----INI----HILKDCPRRQVSCDNCAALVAFEDK-E --IHD------------------------------------------------------Q NCPLANVICEYCN---TILIREQMPNHYDLDCPTA--PIPCTFSTFGCH---E--KMQRN HLARHLQENT---QSHMRMLA--QAVHSLSL--------I----------------P--- -----------------------------------DSG--Y---------------VSEV RNFQETIHQLEGR---LVRQDHQ------------------------------------- -----------------IRELTAK--------------------------METQ-----S TYVSELKRTIRTLEDKVA--E--IEAQQCN-GIYIWKIGNFGMHLKCQEEEKP--VVIHS PGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFV-HTMQGEYDSHLPWPFQGT---IRLT ILDQSEA----PVRQNHEEIMDAKP---DLLA-FQRP------------TIPR-NPKGFG YVTFMHLEALRQR---TFIKDDTLLVRCEVSTRFDM-----------------------G SLRREG--FQPRSTDSGV--- >O_anatinus_ENSOANP00000018657 ----------------MSLLNCENSCGASQSEGDCCAAM-ASACSAGAKDD--S---VSS SV--NTGNLHNSFMAET----------QGYDVEFDPPLESKYECPICLMALRE------- ----------AVQTP--------CGHRFCKACIVKSI-------RDAG---HKCP---VD NEI----------L-LENQ--LFPDNFAKREILSLMVRCPNE--GCLMKMELRQLE---- -----------------------------------------------EH--Q-SLCDYA- LVECPQ-------CHISFQKNI----LHD----HVVSECPRRQVSCVNCALSMAFEDK-E --YHD------------------------------------------------------Q NCPLASVFCEYCS---TVLIREQMPTHYDMDCPTA--PIPCTFSSFGCR---E--KMQRN QLARHLQDDT---QAHMRMMA--QALHSISITALTP---V----------------P--- QLDV--LPFDPA------------------SLPRSSSGYDC---------------HPEV QNFQETIQQLEGR---LVRQDHQ------------------------------------- -----------------IRELIAK--------------------------METQ-----S SHVVDLKRTIRTLEDKIA--E--MEAQQCN-GIYIWKIGNFGMHLKSQEEEKP--VVIHS PGFYTGKPGYKLCMRLHLQLPNAQRCANYISLFV-HTMQGEYDSHLPWPFQGT---IRLT ILDQSEA----PVRQNHEEIMDTKP---ELLA-FQRP------------TIHR-NPKGFG YVTFMHLQALRQR---AFIKDDTLLVRCEVSTRFDM-----------------------S SPRREG--FQPRSTDPGV--- >P_pygmaeus_ENSPPYP00000003845 ----------------MSLLNCENSCGSSQSESDCCVAM-ASSCSAATKDD--S---VGG TA--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALRE------- ----------AVQTP--------CGHRFCKACIIKSI-------RDAG---HKCP---VD NEI----------L-LENQ--LFPDNFAKREILSLMVKCPNE--GCLHKMELRHLE---- -----------------------------------------------DH--Q-AHCEFA- LMDCPQ-------CQRPFQKFH----INI----HILKDCPRRQVSCDNCAASMAFEDK-E --IHD------------------------------------------------------Q NCPLANVICEYCN---TILIREQMPNHYDLDCPTA--PIPCTFSTFGCH---E--KMQRN HLARHLQENT---QSHMRMLA--QAVHSLSL--------I----------------P--- -----------------------------------DSG--Y---------------ISEV RNFQETIHQLEGR---LVRQDHQ------------------------------------- -----------------IRELTAK--------------------------METQ-----S MYVSELKRTIRTLEDKVA--E--IEAQQCN-GIYIWKIGNFGMHLKCQEEEKP--VVIHS PGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFV-HTMQGEYDSHLPWPFQGT---IRLT ILDQSEA----PVRQNHEEIMDAKP---ELLA-FQRP------------TIPR-NPKGFG YVTFMHLEALRQR---TFIKDDTLLVRCEVSTRFDM-----------------------G SLRREG--FQPRSTDAGV--- >P_troglodytes_ENSPTRP00000006096 ----------------MSLLNCENSCGSSQSESDCCVAM-ASSCSAATKDD--S---VGG TA--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALRE------- ----------AVQTP--------CGHRFCKACIIKSI-------RDAG---HKCP---VD NEI----------L-LENQ--LFPDNFAKREILSLMVKCPNE--GCLHKMELRHLE---- -----------------------------------------------DH--Q-AHCEFA- LMDCPQ-------CQRPFQKFH----INI----HILKDCPRRQVSCDNCAASMAFEDK-E --IHD------------------------------------------------------Q NCPLANVICEYCN---TILIREQMPNHYDLDCPTA--PIPCTFSTFGCH---E--KMQRN HLARHLQENT---QSHMRMLA--QAVHSLSL--------I----------------P--- -----------------------------------DSG--Y---------------ISEV RNFQETIHQLEGR---LVRQDHQ------------------------------------- -----------------IRELTAK--------------------------METQ-----S MYVSELKRTIRTLEDKVA--E--IEAQQCN-GIYIWKIGNFGMHLKCQEEEKP--VVIHS PGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFV-HTMQGEYDSHLPWPFQGT---IRLT ILDQSEA----PVRQNHEEIMDAKP---ELLA-FQRP------------TIPR-NPKGFG YVTFMHLEALRQR---TFIKDDTLLVRCEVSTRFDM-----------------------G SLRREG--FQPRSTDAGV--- >B_taurus_ENSBTAP00000021630 ----------------MSLLHCENSCGSSQSESDCCAAMAASSCGTAAKDD--S---VSG TA--STVTLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALRE------- ----------AVQTP--------CGHRFCKACIIKSI-------RDAG---HKCP---VD NEI----------L-LENQ--LFPDNFAKREILSLMVKCPNE--GCLHKMELRHLE---- -----------------------------------------------EH--Q-AHCEFA- LMSCPQ-------CQRPFQKCH----LNI----HILKECPRRQVPCENCAVSMAFEDK-E --IHE------------------------------------------------------Q NCPLANVICEYCN---TMLIREQMPNHYDLDCPTA--PVPCTFSAFGCH---E--KMQRN HLARHLQENT---QSHMRMMA--QAVQTLSL-AVAP---V----------------P--- QCTM--PLYDSV------------------PPTRPSSG--R---------------HSEV HNFQETIQQLEGR---LVRQDHQ------------------------------------- -----------------IRELTAK--------------------------METQ-----S MYVNELKRTIRTLEDKVA--E--IEAQQCN-GIYIWKIGNFGMHLKSQEEEKP--VVIHS PGFYTGKPGYKLCMRLHLQLPSAQRCANYISLFV-HTMQGEYDSHLPWPFQGT---IRLT ILDQSEA----AVRQNHEEIMDAKP---ELLA-FQRP------------TIPR-NPKGFG YVTFMHLEALRQR---TFIKDDTLLVRCEVSTRFDM-----------------------G SLRREG--FQPRSTDSGI--- >H_sapiens_ENSP00000316840 ----------------MSLLNCENSCGSSQSESDCCVAM-ASSCSAVTKDD--S---VGG TA--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALRE------- ----------AVQTP--------CGHRFCKACIIKSI-------RDAG---HKCP---VD NEI----------L-LENQ--LFPDNFAKREILSLMVKCPNE--GCLHKMELRHLE---- -----------------------------------------------DH--Q-AHCEFA- LMDCPQ-------CQRPFQKFH----INI----HILKDCPRRQVSCDNCAASMAFEDK-E --IHD------------------------------------------------------Q NCPLANVICEYCN---TILIREQMPNHYDLDCPTA--PIPCTFSTFGCH---E--KMQRN HLARHLQENT---QSHMRMLA--QAVHSLSV--------I----------------P--- -----------------------------------DSG--Y---------------ISEV RNFQETIHQLEGR---LVRQDHQ------------------------------------- -----------------IRELTAK--------------------------METQ-----S MYVSELKRTIRTLEDKVA--E--IEAQQCN-GIYIWKIGNFGMHLKCQEEEKP--VVIHS PGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFV-HTMQGEYDSHLPWPFQGT---IRLT ILDQSEA----PVRQNHEEIMDAKP---ELLA-FQRP------------TIPR-NPKGFG YVTFMHLEALRQR---TFIKDDTLLVRCEVSTRFDM-----------------------G SLRREG--FQPRSTDAGV--- >G_aculeatus_ENSGACP00000025883 ------------------------------------------------------------ --------------------------------KFVSPLREEFVCPVCGGVVLN------- ----------PQQNS--------CGHIFCFLCLRALR-------ESSPASGPVCP---VD GAA----------I-TPAG--VFQDNCCKREISGLEVYCVN-FPACASVVTLRRLQ---- -----------------------------------------------VE--P-THKQSD- NLVSPE------DVQRFLLKNQQLCPLQE----HLADTCPLRGEPRPHRQPPQRLTFI-Q --DRV-----------------------------------------------------QS SC--LQVDCPESCS--PKAPRHKLE-----SCPEQVEQVDCSYKKFGCS---V--QDTRG RVKLHEDAAV---HRHMLLVL--RSNTHLEQQVEGLREEA-----------------LLM QQEV--QTDGLLLAGLQKT-IRPLLQQKDGRELTVSAAQVN-----------TYQDSYIL GRFPAFLKVVLSL---LSRGSFELE---ELRKSVDAVIQEVSAAEAL------------- --------------RRHLGTLEED--------------------------LKQH-----S GLLDLHAAQLGGNERHLR--E--LGGASFD-GRLIWKIDDFTNRREAEVRGRP--PCLSS VPFHAGTCGYKLASRVYLNGDGEGR-GTHLSLYV-VLMPGDFDALLPWPFRQT---VSLS LLDQSGA------ANHRSLSFRPDP---SSKS-FGRP------------AAESAGNVAVG FSCFLPLGELEPRHNAEYVKDDALFVKVKVD-TAGL-----------------------D PL------------------- >M_domestica_ENSMODP00000024756 ----------------MSLLNCEDSCGTSHPESDCCAGV-ASACSTGTKDD--S---VNG ST--IPGNLPSSLREEI----------QGYDVEFDPPLESKYECPICLMALRE------- ----------AVQTP--------CGHRFCKACIVKSI-------RDAG---HKCP---VD NAI----------L-LETQ--LFPDNFAKREILSLTVKCPNE--GCLLKMELRHLE---- -----------------------------------------------DH--Q-THCEFA- LAECPQ-------CHLPFRKYL----LHN----HMVVECPRRQVSCVNCAAPMPFEEK-E AKFHD------------------------------------------------------Q NCPLATVFCEYCS---TMLIREQMPNHYDIDCPVA--PIPCTFSTFGCR---E--KMPRN HLARHLQEDT---LAHMRMMA--QAIENISIAAFNPK--L----------------H--- QREA--SSYDTS------------------PLPRTP--------------------YPGP QNFQETIQQLESR---LVIQDHQ------------------------------------- -----------------IRELTAK--------------------------METQ-----S ACVGDLKRTIRTLEDRIA--E--MEAQQCN-GIYIWKINNFGMHLKSQEEEKP--VVIHS PGFYTGKPGYKLCMRLHLQLPSAQRCANYISLFV-HTMQGEYDSHLPWPFQGT---IRLT ILDQSEA----PVRQNHEEIMDAKP---ELLA-FQRP------------TIPR-NPKGFG YVTFMHLQALKQR---TFIKDDTLLVRCEVLTRLDM-----------------------N SLRREG--FQPRSTDAGV--- >D_rerio_ENSDARP00000056877 ------------------------------------------------------------ --------------------------MPGLDLKFLERPRRKFYCPLCEKPMRE------- ----------PVQVST-------CGHRFCDTCLQEYL-------SEGV---FTCP---ED QLP----------L-DYAK--IFPDLELEQQILSLPIRCIHSEEGCRWTAQNKLLQ---- -----------------------------------------------AH--L-SVCEFN- VVSCPN------RCSVKLLRRE----LPE----HLQHDCAKRKLHCDHCGEQFTGEAY-E --NHQGVCPEESVYCENKCGARMVRRLLAQHSVSECLKRKLPCRYCKKEFLYDTIQNHQQ QCPRFPMQCPNRCGT-PGITRDTLMAHVKEGCSTA--MVLCPFKEAGCK---H--RSPKT GVARHLEEAA---PTHLSLLC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ GLVNRQRLELRDLRRRME-----ELSGSRD-GTLLWKLTDFSQRLQEAKTRTSGCLELFS PAFYSHNYGYRLQVSAFLNGNGSGE-DTHMSVYL-RVLPGEYDGLLEWPFPYR---VSFS LLDQCDP--ALTKPQHITETFSPDP---TWKN-FQRPRPGALGSIRGGCLDE--SMLGFG YPKFISHEEMKKR---NYIRDNAVFIKASIDVVQKILN---------------------- --------------------- >C_familiaris_ENSCAFP00000010159 ----------------MSLLNCENSCGSSQSESDCCPAM-ASSCSAAVKDD--S---VSG TT--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALRE------- ----------AVQTP--------CGHRFCKACIIKSI-------RDAG---HKCP---VD NEI----------L-LENQ--LFPDNFAKREILSLMVKCPNE--GCLHKMELRHLE---- -----------------------------------------------DH--Q-LHCEFA- LMNCLQ-------CQRTFQKCQ----LNI----HILKECPRRQVSCMNCAALMAFEDK-E --IHD------------------------------------------------------Q NCPLANVICEYCN---TMLIREQMPNHYDLDCPTA--PIPCTFSTFGCH---V--KMQRN HLARHLQENT---QSHMRMLG--QAVQSLSL-ALAP---V----------------P--- QRDV--PPYDSS------------------SVSRVSST--C---------------HPEV QNFQETIQQLEGR---LVRQDHQ------------------------------------- -----------------IRELTAK--------------------------METQ-----S MHVSELKRNIRTLEDKVA--E--IEAQQCN-GIYIWKIGNFGMHLKSQEEEKP--VVIHS PGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFV-HTMQGEYDSHLPWPFQGT---IRLA ILDQSEA----PVRQNHEEIMDAKP---ELLA-FQRP------------TIPR-NPKGFG YVTFMHLEALRQR---TFIKDDTLLVRCEVSTRFDM-----------------------G SPRREG--FQPRSTDSGI--- >G_aculeatus_ENSGACP00000022648 -------MASAE-SGKGSLQEDSYEGPVGGELSGCALAM-MEKERESLLSP--S---ESP GTFISGSSASLQAPAPL----------QGYDVEFDPPLESKYECPICLMALRN------- ----------AIQTP--------CGHRFCKNCIEKSI-------RDTG---QRCP---VD NER----------L-LEDQ--LFPDNFAKREILSLTVRCPNS--DCADKMELRHLE---- -----------------------------------------------NH--L-GRCQFA- TVPCSQ-------CQQAVRKSR----LEE----HQTAECQKRPVSCPDCVASFFYEER-K --LHQ------------------------------------------------------Q RCPFAIVKCLFCD---LELIRDQIESHCDTDCPKA--PIACNFSAFGCK---E--SMQRH NLAQHMQEFT---QMHMRYMA--EFLRGLSLNGTTP---K----------------SLWA PAPS--AYPEDQGATAALAAVCSGP--RGAPSSMSSNS--CAPSQ----------PAEGM QRLR----EMDGR---LVKQDHQ------------------------------------- -----------------LRELIIL--------------------------KETQ-----A GQLAELRRRVSLLEDTVK--E--LESQQCH-GIFIWRLRGFSAHLRNQEAGQP--VVEHS PGFYTGRPGYKLCLRLHLQTPNAPRCSNFISLFV-HTMQGAFDGQLSWPFQGT---IRLA ILDQ--G----PEAQHHVEVMETKP---DLQA-FQKP------------LIQR-NPKGFG YVTFLHLHQLTQR---AFVKDDTLLIRCEVTPRFD------------------------N VLHRDGPTVQPRGPEASVSRD >T_rubripes_ENSTRUP00000041697 -------MACFD-SSKESL-EDSFDGAAGGKLSGCALAM-SEKERESLLNP--S---ESP STYMSGASSSFQDATHQ----------QGYDVEFDPPLESKYECPICLMALRN------- ----------AIQTP--------CGHRFCKICIEKSI-------RDAG---QRCP---VD NEM----------L-SKEQ--LFPDNFAKREILSLTVRCSNP--GCTGKMELRHLE---- -----------------------------------------------DH--L-AHCQFA- TVPCPH-------CQQSVRKTI----LEE----HMTAECRRRPVSCPDCIETFVYEER-E --RHE------------------------------------------------------Q QCPFASVMCPYCD---MDLVRDQMESHCDTDCPIA--PIACTFSLFGCK---E--RMQRH DLARHMQDFT---QMHMHYMA--DFLRGLNLNGTTP---K----------------PLGA IGHS--ISFEDHGASAS-----------SCDKGVSSSN--CAPCQ----------PNEET QRLR----EMDRR---LVKQDHQ------------------------------------- -----------------LRELIIL--------------------------KETQ-----A GQLAELGRRVSMLEETVR--E--LESQHCT-GIFIWRLKDFSVLLRNQEAGLP--VVEHS PAFYTGRPGYKLCLRLHLQSPNAQRCSNFISLFV-HTMQGAFDGRLTWPFQGT---IRLA ILDQ--G----PEGQHHVEVMETKP---DLQA-FQKP------------TIIR-NPKGFG YVTFLHLQQLNQR---AYVKDDILLIRCEVTPRFD------------------------N MFHRDGITVQPRGPEASM--- >X_tropicalis_ENSXETP00000042386 ------------------------------------------------------------ ---ANLSSVPVENEFVF----------GYPTTICDVAPGEKYLCCSCNSVSLN------- -----------------------RNHDLCPKCKAE------------------------- ---------------DPTT--LSDDSLLKEERFAF------------------------- -----------------------------------------------------NYTNAQ- LIVCP------------------------------------------------------- --EHS------------------------------------------------------- ----------------------------------------------------F--SGSRE KIKEHYRTSA---AAHLSLVC--PLILRIKDNLTNTEDST-------------DGPGQKN PFSLQAEDFKAGNGDLELDCGHAVGQPSDEVA-------------------------NRL SLLETRLQVFENI---ISVLSKEIDSS-QSQLAAIKEQKAEE------------------ --------------ERKVKALEHK--------------------------VENL-----R CTLAMKDIVLNELEMRSA--C--LEQTSYD-GVFLWKISDLTNKSHDAVTGRA--ISLYS PVSPSFK-GKSIPSLFPVSLSFKGKSTPHCFLFHPVSRRSQSPSLFPVSLSFK---VTFV LVDHNNR-------DSVFDAFRPDV---TSAS-FQRP------------IND--MNVASG CPLFCPIAKLNSPKH-AYIRENTLYIRCIIDTNS-------------------------- --------------------- >T_nigroviridis_ENSTNIP00000012472 -------MACFDSSSKGSLEEDSCDGAIGGELSGCALVM-MEKEQESLLSP--S---ESP GTYMSGASSSFHDGTHQ----------QGYDVEFDPPLESKYECPICLMALRN------- ----------AIQTP--------CGHRFCKNCIEKSI-------RDAG---QRCP---VD NEM----------L-SKEQ--LFPDNFAKREILSLIVRCSNP--GCTSKMELRHLE---- -----------------------------------------------NH--L-ASCEFA- TVPCPH-------CQQSVKKTL----LEE----HTSVQCRRRPVSCPDCVEIFVYEEK-E --RHE------------------------------------------------------Q QCPFASVMCPHCD---MDLTRDQMESHCDTDCPKA--PIACNFSLFGCK---E--RMQRH DLARHMQDFT---QMHMHYMA--DFLRSLNLNGTIP---K----------------DQGA ------------AASAS-----------SCSKGALSSN--CTPCQ----------PTEEM QRLR----EMDRR---LVKQDHQ------------------------------------- -----------------LRELIIL--------------------------KENQ-----T GQIAELRKRVSVLEESMR--E--LESQHCT-GIYIWRLKDFSVLLRNQEAGLP--VVEHS PGFYTGRPGYKLCLRLHLQSPVAQRCSNFISLFV-HTMQGAYDGLLTWPFQGT---IRLA ILDQ--G----PEGQHHIEVMETKP---DLQA-FQRP------------TIIR-NPKGFG YVTFLHLHHLKER---AYVKDDALLIRCEVTPRFD------------------------N MLHRDGVTVQPRGSEASI--- >M_mulatta_ENSMMUP00000028200 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SEGV---FKCP---ED QLP----------L-DYAK--IYPDPELEVQVLGLPIRCIHSEEGCRWNGPLRHLQ---- -----------------------------------------------GH--L-NTCSFN- VVPCPN------RCPMKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E --SHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQY QCPRLPVPCPNQCGV-GTVAREDLPGHLKDSCSTA--LVLCPFKDSGCK---H--RCPKL AMARHVEESV---KPHLAMMC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ALVSRQRQELQELRRELE-----ELSVGSD-GVLIWKIGSYGRRLQEAKAKPN--LECFS PAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI-RVLPGAFDNLLEWPFARR---VTFS LLDQSDP--GLAKPQHVTETFHPDP---NWKN-FQKP-----GTWRGS-LDE--SSLGFG YPKFISHQDIRKR---NYVRDDAVFIRAAVELPRKILS---------------------- --------------------- >P_troglodytes_ENSPTRP00000015252 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------L-------SEGV---FKCP---ED QLP----------L-DYAK--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ---- -----------------------------------------------GH--L-NTCSFN- VIPCPN------RCPMKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E --SHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQY QCPRLPVACPNQCGV-GTVAREDLPGHLKDSCNTA--LVLCPFKDSGCK---H--RCPKL AMARHVEESV---KPHLAMMC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ALVSRQRQELQELRRELE-----ELSVGSD-GVLIWKIGSYGRRLQEAKAKPN--LECFS PAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI-RVLPGAFDNLLEWPFARR---VTFS LLDQSDP--GLAKPQHVTETFHPDP---NWKN-FQKP-----GTWRGS-LDE--SSLGFG YPKFISHQDIRKR---NYVRDDAVFIRAAVELPRKILS---------------------- --------------------- >D_rerio_ENSDARP00000036715 -------MACND-VDKSSFDDVCCD----SGHSSCA-AA-MEKERESFLSP--T---ENP STI----SVSSSMPPDQ----------QGYDVEFDPPLESKYECPICLMGLRS------- ----------AVQTP--------CGHRFCDSCIRKSI-------RDTG---QKCP---VD NEV----------L-LEEQ--LFPDNFAKREILSLTVKCSNF--GCSEKMELRQLE---- -----------------------------------------------KH--L-SQCRFA- TAPCPQ-------CQESVPISH----LDE----HKSQHCLQRIMTCPDCAGSFVYAVK-Q --NHE------------------------------------------------------Q FCPFANTVCEYCE---MELIRDQLALHCDTDCLKA--PVACTFSTFGCR---E--KMTRN ELAQHMQEFT---QMHMRYMA--EFLRSQTLNNCTM---P----------------S--- ----------------AAAHLSSDD--RGA-SARSPDS--C---Q----------CKQEL LNLRETVLELEGR---LVRQDQQ------------------------------------- -----------------IRELCIH--------------------------NDTQ-----K NQVTELRRKLVSLEESTR--E--LEAQQYQ-GIYVWRVENFSHHLRNQEAGQP--IVLHS PPFYTGRPGYKLCLRLHLQTPSAPRCSNFISLFV-HTMQGEFDSQLSWPLQGT---IRLA VLDQ-------VEGQHHIEVMETKP---DLQA-FQRP------------TVMR-NPKGFG YVTFLHLQALRQR---GFVKEDVLLVRCEVTPRFD------------------------A SLRREG--VQPRGPEPSI--- >E_caballus_ENSECAP00000009502 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SEGV---FKCP---ED QLP----------L-DYAK--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ---- -----------------------------------------------GH--L-NTCSFN- VVPCPN------RCPTKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAF-E --SHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCAKEFVFDTIQSHQY QCPRLPVPCPNQCGV-GTVAREDLPGHLKDSCSTA--LVLCPFKDSGCK---H--RCPKL AMARHVEESV---KPHLAMMC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ALVSRQRQELQELRRELE-----ELSVGSD-GVLIWKIGSYGRRLQEAKAKPN--LECFS PAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI-RVLPGAFDNLLEWPFARR---VTFS LLDQSDP--GLAKPQHVTETFHPDP---NWKN-FQKP-----GTWRGS-LDE--SSLGFG YPKFISHQDIRKR---NYVRDDAVFIRASVELPRKILS---------------------- --------------------- >P_pygmaeus_ENSPPYP00000009119 ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------EGV---FKCP---ED QLP----------L-DYAK--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ---- -----------------------------------------------GH--L-NTCSFN- VIPCPN------RCPMKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E --SHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCSKEFVFDTIQSHQY QCPRLPVACPNQCGV-GTVAREDLPGHLKDSCNTA--LVLCPFKDSGCK---H--RCPKL AMARHVEESV---KPHLAMMC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ALVSRQRQELQELRRELE-----ELSVGSD-GVLIWKIGSYGRRLQEAKAKPN--LECFS PAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI-RVLPGAFDNLLEWPFARR---VTFS LLDQSDP--GLAKPQHVTETFHPDP---NWKN-FQKP-----GTWRGS-LDE--SSLGFG YPKFISHQDIRKR---NYVRDDAVFIRAAVELPRKILS---------------------- --------------------- >X_tropicalis_ENSXETP00000016445 ----------------MSILNCRPSFDGVDTDDACCGAM-ASACCVNTKEDGES---PSA GS--PSGTPQSLVLEDV----------QGYDVEFDPPLESKYECPICLMALRE------- ----------AVQTP--------CGHRFCKACILKSI-------RDAG---HKCP---VD NES----------L-MENQ--LFPDNFAKREILSLRVKCPSQ--GCTETMELRHLE---- -----------------------------------------------RH--L-VRCDFA- GVECSQ-------CQSSFPKYS----LQK----HMFEECPRRQIFCENCALAMALEDK-L --NHD------------------------------------------------------Q TCPLAYVTCEYCQ---TNLIREQMPAHYSMDCTMA--PIPCMYYEFGCT---E--KMQRN DLARHLQEFT---QAHMRMMA--QTLRSFSS-SVTPTSHM----------------PDIS FCDP--SQFEPAPPSVA-----------TVHSSHTPSQNDC---------------TQET RNLRETIEQLEGR---LVRQDHQ------------------------------------- -----------------IRELIAK--------------------------METQ-----C TYVNELKHTIRSLDNRLG--E--MESQQCS-GIFIWRINNFNSLLKNQEEERP--VVIHS QGFYTGKPGYKLCLRLHLQLPSAQRCANYISLFV-HTMQGEYDSLLPWPLQGT---IRLS ILDQSEG----VAMQDQEEVMDTKP---ELLA-FQRP------------TVAR-NPKGFG YVTFMHLQALKQR---QYVKNDTLLVRCSVTTHLDL-----------------------I SPRREG--FQPRSGDGAL--- >B_taurus_ENSBTAP00000016271 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------Q--IYPDPELEVQVLGLSIRCIHSEEGCRWNGPLRHLQ---- -----------------------------------------------GH--L-NTCSFN- VVPCPN------RCPAKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAF-E --SHEGVCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQY QCPRLPVPCPNQCGV-GTVAREDLPGHLKDSCSTA--LVLCPFKDSGCK---H--RCPKL AMARHVEESV---KPHLAMMC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ALVSRQRQELQELRRELE-----ELSVGSD-GVLIWKIGSYGRRLQEAKAKPN--LECFS PAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI-RVLPGAFDNLLEWPFARR---VTFS LLDQSDP--GLAKPQHVTETFHPDP---NWKN-FQKP-----GTWRGS-LDE--SSLGFG YPKFISHQDIRKR---NYVRDDAVFIRASVELPRKILS---------------------- --------------------- >O_latipes_ENSORLP00000001290 --------------------------ASGGGLSECASAM-LEKERESLPSP--S---DNP TA--SMGSSSLQAAAPL----------QGYDVEFDPPLESKYECPICLMALRN------- ----------AIQTR--------CGHRFCKSCIEKSI-------RDTG---QRCP---VD NEM----------L-SEDQ--LFPDNFAKREILSLTVRCPNS--DCGEKMELRHLE---- -----------------------------------------------KH--L-AQCQFA- TVPCSQ-------CQQPVRKSY----LEE----HATVECPRRPMSCPDCVAVFVYEER-E --MHE------------------------------------------------------Q QCPFASVMCQYCE---MDLIRDQMESHCDTDCPKA--PIACTFSIFGCK---E--RMQRH NLAQHMQEFT---QMHMRYMD--IRMTTLTKKTKTT---K----------------NALI VIYF--FFPKICVFLVQLQHRLRGSSTRSAASQLILQS--C---EFTLYSHSKRLVKNCF YHLR-NVAKLKPM---LTRSDLELIID-SVKCFKAQGFPSLVKCQNILKTP----KT--- --------------QFSLEWVLRH--------------------------KDRKSNHKLA GQLAELRRRVSVLEETVK--E--LEAQQYH-GIFIWRLKAFSTHLRSQEAGIP--VVEHS PGFYTGRPGYKLCLRLHLQTPTAPRCSNFISLFV-HTMQGVFDSQLTWPFQGT---IRLA ILDQ--G----PEGQHHMEVMETKP---DLQA-FQKP------------INQR-NPKGFG YVTFMHRSLLSQR---AYVKDDTLLIRCEV------------------------------ --------------------- >G_gorilla_ENSGGOP00000016344 ------------------------------------------------------------ --------------------------MPGFDYKFLEKPKRRLLCPLCGKPMRE------- ----------PVXXPP-------CGHRFCDTCLQEFL-------SEGV---FKCP---ED QLP----------L-DYAK--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---- -----------------------------------------------XX--X-XXXXXX- XXXXXX------RCPMKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E --SHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQY QCPRLPVACPNQCGV-GTVAREDLPGHLKDSCNTA--LVLCPFKDSGCK---H--RCPKL AMARHVEESV---KPHLAMMC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ALVSRQRQELQELRRELE-----ELSVGSD-GVLIWKIGSYGRRLQEAKAKPN--LECFS PAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI-RVLPGAFDNLLEWPFARR---VTFS LLDQSDP--GLAKPQHVTETFHPDP---NWKN-FQKP-----GTWRGS-LDE--SSLGFG YPKFISHQDIRKR---NYVRDDAVFIRAAVELPRKILS---------------------- --------------------- >X_tropicalis_ENSXETP00000056667 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SEGV---FKCP---ED QLP----------L-DYAK--IYPDRDLETQVMGLSIRCIHSEEGCRWSGQLKQLQ---- -----------------------------------------------PH--L-NICAFN- VIPCPN------RCSTKLIRRD----LPE----HMQHDCPKRKVRCEFCGADFTGEAY-E --DHQGCCPQESVYCENKCGARMMRRVLSQHSLVECPKRTQPCPYCNKEFVFDTIQSHQY QCPRYPTPCPNQCGI-ASIAREDLSNHLKDSCSSA--LVLCPFKDSGCK---H--RGPKI TISRHLEENM---RAHLSMMS--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ SLVSRQRQEILELRKQVE-----ELSVSSE-GVLIWKISDYSRKVQEAKVRGN--FESFS PPFYTHKYGYKLQVSAFLNGNGSGE-GSYLSVYI-RVLPGEYDNLLEWPFSYR---VTFS LLDQSDP--SLSKPQHITETFNPDP---NWKN-FQKP-----TGSRNS-LDE--STLGFG YPKFISHEDIRKR---NYVRDNAIFLRASVEIPQKIIA---------------------- --------------------- >E_caballus_ENSECAP00000018618 ----------------MSLLNCENSCGSSQTESDCCAAM-ASSCSAAAKDD--S---VSG TA--STGNLSSSFMEDI----------QGYDVEFDPPLESKYECPICLMALRE------- ----------AVQTP--------CGHRFCKACIIKSI-------RDAG---HKCP---PD -EI----------L-YHP-----ASSLTRRESL-LCPMCPHC--MCYPPSKLYHRS---- -----------------------------------------------DH--Q-AHCEFA- LMNCPQ-------CQHPFQKCQ----LNI----HMLKECPRRQVSCVNCAVSMAFEDK-E ASIHD------------------------------------------------------Q NCPLANVICEYCN---TMLIREQMPNHYDLDCPTA--PIPCTFNTFGCH---E--KMQRN HLARHLQENT---QSHMRMLA--QAVQSLSL-ALAP---V----------------P--- QRDM--LPYDSA------------------PLSRVSSG--C---------------YPEV RNFQETIQQLEGR---LVRQDHQ------------------------------------- -----------------IRELTAK--------------------------METQ-----S IYVSELKRTIRTLEDKVA--E--IEAQQCN-GIYIWKIGNFGMHLKSQEEEKP--VVIHS PGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFV-HTMQGEYDSHLPWPFQGT---IRLT ILDQSEA----PIRQNHEEIMDAKP---ELLA-FQRP------------TIPR-NPKGFG YVTFMHLEALRQR---TFIKDDTLLVRCEVSTRFDM-----------------------G SLRREG--FQPRSTDTGV--- >T_nigroviridis_ENSTNIP00000019321 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------VKLTRRD----LPD----HLQHDCPKRKVKCEFCGSEFTGEAY-E --NHQGVCPQESVYCENKCGARMMRRLLSQHGMAECPKRTQPCKYCGKEFVFDTIQNHQY HCPRFPVQCPNQCGT-PNIAREDLANHVKDNCGSA--LVLCPFKDAGCK---H--RCPKL AIGRHLEDTT---KSHLTMMC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ NLVGRQRQEILELRREME-----ELSVSHD-GILIWKLNDYSRKLQEAKIRSN--HEFFS PPFYTHRYGYKLQVSAFLNGNGSGE-GSHLSVYI-RVLPGEYDNLLEWPFSYK---VTFS LLDQSDP--SLSKPQHITETFNPDP---NWKN-FQKP-----NSTRNS-LDE--STLGFG YPKFISHEEIKKR---NYIRDNCIFIKASIEIPQKIMA---------------------- --------------------- >O_cuniculus_ENSOCUP00000000748 ------------------------------------------------------------ --------------------------MPGFDYKFLEKPKRRLLCPLCGKPMRE------- ----------PVKVST-------CGHRFCDTC-QSFL-------XXXX---XXXX---XX XXX----------X-XXXX--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ---- -----------------------------------------------GH--L-NTCSFN- VVACPN------RCPAKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E --SHEGMCPQESVYCENKCGSRMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQY QCPRLPVPCPNQCGV-GTVAREDLPGHLKDSCSTA--LVLCPFKDSGCK---H--RCPKL AMARHVEESV---KPHLAMMC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ALVSRQRQELQELRRELE-----ELSVGSD-GVLIWKIGSYGRRLQEAKAKPN--LECFS PAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI-RVLPGAFDNLLEWPFARR---VTFS LLDQSDS--GWARPQHVTETFHADS---NWEEAFQKP-----GTWRGS-LDE--SSLGF- ------------------------------------------------------------ --------------------- >M_mulatta_ENSMMUP00000021905 -------------------LNCENGCGSSQSESDYCVAM-ASSCSAATKDD--S---VGG TA--SMGNLSSSFMEEI----------QGYDVEFDPPLESRYECPICLTALRE------- ----------AVQTP--------CGHRFRKGCIIKSI-------RDAG---HKCP---VD DEI----------L-LENK--LFPDSFAKREILSLMVNCPNE--GCLHKMELRHLG---- -----------------------------------------------DH--Q-AHCEFA- LMDCPQ-------CQHPFQKFH----INI----HILKDCPRRQVSCDNCAASMAFIKR-S --V-D------------------------------------------------------Q NCPLANVICEYCN---TILIREQ-ASYYDVDCPTA--PIPCTFRTFDCH---E--KMQRN HLSHHLQE-T---PCHTRMLT--QAVHSLSL--------I----------------P--- -----------------------------------DSG--Y---------------ISEA RNFQETSHQLEDR---LVGQDNQ------------------------------------- -----------------IQELTDE--------------------------IETQ-----S IYVSE----IRTLEDKVA--D--IEAQQCN-GIYIWKIGS---HLKCQEEEKP--VVIHS PGFYTGKPGYKLCMRLHLQLLTAQRCANYISLFV-HTMQGEYDSHLPWPF-GT---ICLT ILDQSQA----PVRQNHEEIMDAKP---ELLA-FQQP------------TYP--NPKGFG YVTFIHLEALRQR---TFIKYDTLLVRCEVSTCFDM-----------------------G SLRREG--FQPQSTDAGI--- >C_intestinalis_ENSCINP00000003738 ------------------------------------------------------------ -------------------------------------------CVECKYTLEF------- ----------PVALSN-------CEHHACSQCVSRLW-------KIS----RSCP---LD GKV----------I-DRNE--VTIDEKLQIELNNLNMVCPYKHCGCHWEGMFFDFK---- -----------------------------------------------SH--Y-DECLYT- EEVCSN------DCGFRCSKHL----MDN----HLQIECSKRLVVCEFCALHLKAENE-I --EHL------------------------------------------------------K SCIRFPVTCPKKCGT-KEIPREELNAHLELDCQLA--DKVCPYETVGCT---F--TCSRE KMATHVDECF---RKHVSLLC--DGFRK-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------QAELLGLQKK------------------------------------ -QLFEHKQILHDHGKMVR--NGIFSNIEFD-SQLLWKISEWSSKKIEAEAGKR--TVLQS PLFYSARFQYKLAVLLLPNGDGKAK-GTHLSIYV-RLCKGEYDALLSWPYRLP---IEIS LIDQSQD---PRARINHTYSLRPNPCKENKPF-LGRP------------TSE--SNPSFG SQTFMPLDTLNTR---DYIRDDAIFIRVSVLHDET------------------------- --------------------- >O_anatinus_ENSOANP00000028670 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------FFSS----------------------------------- ------------------------------------------------------------ -----------------------------------------------------------Q --AHD------------------------------------------------------E ICPKFPLTCEGCGK--KKIPREKFQDHVK-TCGKC--RTPCRFQVVGCP---EMPGRRVH LPDFRTRPTRREHRNHLFFFFFKKKQRETKKRHTTTKKFLEDGWIDRSDRRVRSGPPSSR ALSSGPPRASAGADTGSSGWTRSPSPVGLTGSAPVFRMRDPRPGEATPLAFSSGGAGPIL GTFKKKKTTNQTT---EQTQTGGGGGV-SVSSLSFAFLRGADPVKGVSRNPPPTERGPRS GGPVARRGREGREGRAPATVSNRQ--------------------------VQQL-----E RSIGLKDLAMADMQQQIH--D--MEASTYD-GIFIWKITDFARKRQEALAGRS--PAIFS P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >O_cuniculus_ENSOCUP00000010330 ----------------MSLLNCENSCGSGQSESDCCAAM-ASSCSAAAKDD--S---VSG TA--STGNLSGSFVEDI----------QGYDVEFDPPLESKYECPICLMALRE------- ----------AVQTP--------CGHRFCKACIIKSI-------RDAG---HKCP---VD NEI----------L-LENQ--LFPDNFAKREILSLTVKCPNE--GCLHKMELRHLE---- ---------------------------------------------XXXX--X-XXXXXX- XXXXXX-------XXXXXXXXX----XXX----XXXXXXXXXXXXXXXXXXXXXXXXX-X --IHD------------------------------------------------------Q NCPLANVICEYCN---TMLIREQMPNHYDLDCPTA--PIPCTFSTFGCH---E--KMQRN HLARHLQEKT---QLHMRMLA--QAVHSLNL-ALTP---I----------------P--- -----------------------------------DSG------------------YPEG HNFQETIQQLEGR---LVRQDHQ------------------------------------- -----------------IRELTAK--------------------------METQ-----S MYVSELKRTIRTLEDKVA--E--IEAQQCN-GIYIWKIGNFGMHLKSQEEEKP--VVIHS PGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFV-HTMQGEYDSHLPWPFQGT---IRLT ILDQSEA----PIRQNHEEIMDAKP---ELLA-FQRP------------TIPR-NPKGFG YVTFMHLEALRQR---TFIKDDTLLVRCEVSTRFDM-----------------------G SLRREG--FQPRSTDAGV--- >C_elegans_F45G2.6 ------------------------------------------------------------ --------------------------MTSQSVMFKGGLPADCTCPICEQALRD------- ----------PIKLN--------CDHHYCRQCFEN---------ENRT---PGCA---AC QTI----------I-QPEL--CQHDRAKQKQILALPVVCTFESSGCPWDGQLGTLH---- -----------------------------------------------DH--L-SECTFKS SLKCEK-------CGRQFAKND----LEK----H-RAKCELNRAVCSFCNKTIRDSDR-E --RHP------------------------------------------------------K TCPQVIISCPFQCGL-TDRPRLEIEAHCP-SCPNV--DNVCPFVPYGCT---F--AGGKE SIQQHLSDEP---VRHLMYLC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------DEITDLKGT--------------------------YELM-----E RDMGSFNDRQTRILSAAE-----TCTEMFG-PQLIWKIDKLQQRTNEAKSGAD--TTIFS VPFMSHRFGYKMMACACLFGDGSSA-GKSISLYV-LLLKGEFDPTLEWPFHRA---IKIS LLDQNPRPEDRVNITYVIDPRKLKA---NEKF-LARP------------RGE--RNAAFG SQSFCSLAILQ-----NYVKDDKIYVQIDVDRCETLPVQLKSRDAKERKQMLDAMRAKTP DVRLHQVRPVTSQSSSAELRV >D_melanogaster_FBpp0111838 -----------------MPAPPATVKPATGHTTKLNNGKSSNSNSNHTLSNSIAHLSDSR TNLTVNTPTTCQRLSEMFRRSIASSTQSSSRENTYEEWTKTLSFPSRLSPNRNSKDCSTL ASPV-PPPTPPRNKTTSGSGNCATSRSSSSTVSSSHS-------SSHS---SPTPGNNNN NMP----------I-TELEQIIYPGPDP-KHIMGSLVFCIHHKQGCKWSDELRKLK---- -----------------------------------------------GH--L-NACKHD- ATQCPN------KCGAQIPRIM----MTD----HLQYTCTMRRTRCEFCQSEFSGAGL-E --EHNGSCGQEPVYCEAKCGQRILRGRMTLHKSKDCAKRLRRCAHCQREFSADTLPLHAA QCPRAPLACPQRCDA-GPIPRGELEAHLRDECQSL--AVSCSFKEAGCR---F--KGPRQ MLEAHLESNA---AAHLSLMV--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ALSSRQGQQIQMLKSAVS-----KLSINYT-GTLLWKITDWSAKMAEARGKDG--LELVS PPFYTSQYGYKLQASMFLNGNGPGE-NTHVSVYI-KVLPGEYDALLKWPFSHS---ITFT LFEQGAQ----SGQGGVAESFVPDP---TWEN-FQRP------------SNEP-DQLGFG FPRFISHELLHSR---PFIKGDTVFLRVKVD-PSKIVAV--------------------- --------------------- >A_gambiae_AGAP010017-PA ------------------------------------------------------------ ------------------------------MVRSLSQWTKTLSFPARISPNRNSKDCNVN VLPITPPPAPPRNKST--S----TSSASTMSSSSSPS-------SSSS---SPTP---PP NVP----------I-TEISQIIYPDPESEKAIMGSLVFCIHHKQGCKWSDELRKLK---- -----------------------------------------------AH--L-NTCKHD- AIQCPN------KCGSQIPRVM----MTD----HLAFTCILRRAICEFCNVEFTGIGL-E --EHAGTCSSEPIYCESKCGTRVLRGRMSIHRAKDCAKRLRRCPHCGREFCADTLAAHGA TCPRSPIPCPQRCDA-GPFARADLDAHLRDECKAL--TVPCTFKEAGCR---F--KGPRH LLEAHLEANT---SAHLSLMV--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ALSGRQGQQINMLKSAMA-----KLSTNYT-GTLLWKITDWSVKMQEAKTKDG--LELVS PPFYTSQYGYKLQASMFLNGNGPGE-GTHVSVYI-KVLPGEYDALLKWPFSHS---VTFT LFEQGTLGSGGGGQGGVAESFVPDP---TWEN-FQRP------------STEP-DALGFG FPRFVSHELLNRR---PFVRDDTVFLRVKVD-PSKIVAV--------------------- --------------------- >O_anatinus_ENSOANP00000019424 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------PCPYCTKEFVFDTIQNHQY QCPRFPLPCPNQCGT-GAVAREDLPGHLKENCNTA--PVLCPFKDAGCK---H--RCPKL AMSRHLEDSV---KLHLGLTW--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ALVSRQRQELQELRRDVE-----ELAAGSD-GVLVWRIGGYGRRLQEARGRPN--HECLS RPFYTHKYGYRLQVSAFLNGNGSGE-GTHLSLYI-RVLPGDYDNLLEWPFALR---VTFS LLDQSDP--SLSKPQHVTETFHPDP---HWKN-FQKP-----GAWRGS-GSSG-AALGFG YPKFISHEDIRKR---DYVRDDAVFIRAAVELPRRILA---------------------- --------------------- >A_aegypti_AAEL006649-PA ------------------------------------------------------------ ------------------------------MVRSLSQWTKTLSFPARISPNRNSKECSVN VLPITPPPAPPRNKSTTST----TSSASSSTSALSHS-------SATS---SPSP---PP NVP----------I-TEISQIIYPDPESEKAIMGSLVFCIHHKQGCKWSDELRKLK---- -----------------------------------------------AH--L-NTCKHD- AIQCPN------KCGSQIPRVM----MTD----HLAFTCILRRAICEFCNVEFTGIGL-E --EHAGTCSSEPIYCESKCGTRVVRGRMSIHRAKDCAKRLRRCPHCSREFSADTLSAHGA TCPRSPVPCPQRCDA-GPFARADLEGHLRDECKAL--SVPCTFKEAGCR---F--KGPRH LLEAHLESNT---SSHLSLMV--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ALSGRQGQQINMLKNAMA-----KLSTNYT-GTLLWKITDWSAKMVEAKSKDG--LELVS PPFYTSQYGYKLQASMFLNGNGPGE-GTHVSVYI-KVLPGEYDALLKWPFSHS---VTFT LFEQGTL----GSQGGVAESFVPDP---SWEN-FQRP------------STEP-DALGFG FPRFVSHELLNRR---PFVREDTVFLRVKVD-PSKIVAV--------------------- --------------------- >C_familiaris_ENSCAFP00000027741 ------------------------------------------------------------ --------------------------MPGFDYKFLEKPKRRLLCPLCGKPMRE------- ----------PVQVST-------CGHRFCDTCLQEFL-------SEGV---FKCP---ED QLP----------L-DYAK--IYPDPELEVQVLSLAIRCIHSEEGCRWSGPLRHLQ---- -----------------------------------------------SH--L-NTCSFN- VIPCPN------RCPTKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAF-E --SHEGVCPQESVYCENKCGARMMRRLLAQHAASECPKRTQPCTYCTKEFVFDTIQSHQY QCPRLPVPCPNQCGV-GTVAREDLPGHLKESCSTA--LVLCPFKDSGCN---T--GCPAF PLAPLVPEASYADQAHGGSCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EAATGLLSALYLPRSELG-----TCSSPRE-PPWAWSAYEAS-----GTKGANGKEEDQN IRAFVSCYGYII----ILENPITPI-NHHSSLYI-RVLPGAFDNLLEWPFARR---VTFS LLDQSDP--GLAKPQHVTETFHPDP---NWKN-FQKP-----GTWRGS-LDE--SSLGFG YPKFISHQDIRKR---NYVRDDAVFIRASVELPRKILS---------------------- --------------------- >C_intestinalis_ENSCINP00000008928 ------------------------------------------------------------ --------------------------MPGYQNKFVDKVRKRHQCPLCHFPMRD------- ----------PVQITA-------CRHRYCDTCLQKFL-------GEGV---FNCP---VD HLS----------L-DYAK--IYPDPDLETEIMSLTTHCTNYSSGCKWTGKLHNLK---- -----------------------------------------------AH--M-DKCSHS- ERDCPN------RCGVRIRSMK----LAD----HLEYECMKRRVACDFCGKEFTGEMM-D --EHEGACPQESVHCENKCGAKMLRKYLSRHVTGDCPKRPTKCTHCSKDFNIDILQTHHG TCPRYPIGCPNRCDV-LKIPREELEIHLKEHCKSA--LTACPFKEAGCK---H--KCPRY HLERHLTEAN---ASHIRAMF--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ DLVKTQRSHISELQKQLS-----DLTVNTN-GTLLWKIPGYSQKLQAAQKDQA--IEMRS PPFYTHRYGYKLQLSAFLNGNGSGL-NSHMSLY--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >G_gorilla_ENSGGOP00000012479 -------------------------------------------------MAYSEEHKGVP CGFIRQNSGNSISLDFE----------PNIEYQFVERLEERYKCAFCHSVLHN------- ----------PHQTG--------CGHRFCQHCILSLR-------ELNT--VPICP---VD KEV----------I-KSQE--VFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQ---- -----------------------------------------------DH--L-QQCLFQ- AVQCSNE-----KCREAVLRKD----LKE----HLSAYCQFREEKCLYCKKDVVVINL-Q --NHE-----------------------------------------------------EN LCPEYPVFCPNNCA--KIILKTEVDEHLA-VCPEA--EQDCPFKHYGCA---V--TXXXX XXQEHEHSAL---REHMRLVL--EKNVQLEEQISDLHKSL-----------------EQK ESKI--QQLAETIKKLEKE-FKQFAQLFGKNGSFLPNIQVF------------ASHIDKS AWLEAQVHQLLQM---VNQQQNKFDLR-PLMEAVDTVKQKITLLENS------------- --------------DQRLAVL--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >O_latipes_ENSORLP00000024257 -----------------------MSAGRSADGREVQIPLQQAAPSLALP----------- -LSAAVPAPPPGFLPVR----------GGFRDHFVEAPEAKYCCEACRLVLCQ------- ----------PRQTE--------CGHRFCYSCINDIL-------SCPN---PVCP---AD MEP----------L-FKDK--VGRKPADPSELMHLHPSATPPTCGSPTHLCHLCPQ---- -----------------------------------------------DH--V-NVCPFF- EVPCPLG-----KCKERMMRKE----IPE----HLAWKCKYRESTCEFCKNKMPLTEL-Q --KHK-----------------------------------------------------ET VCPAFPVSCPNHCTS-SSLPRSELSSHQH-DCPKA--QVSCQFHRYGCS---F--KGLNL DMRQHESSFA---AEHLKMMA--TRTGLLETKVEEVKGEL-----------------MER YKVL--PALSTRLSDLESQ-TDDLREKNRQMEQKLAAMQKL-----------MSSHTEKL LELELELRSLRQL---RDEME-------SLRGTLDTVRTRLSALEHSCINTQS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >G_gorilla_ENSGGOP00000005734 ----------------MSLLNCENSCGSSQSESDCCVAM-ASSCSAATKDD--S---VGG TA--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALRE------- ----------AVQTP--------CGHRFCKACIIKSI-------RDAG---HKCP---VD NEI----------L-LENQ--LFPDNFAKREILSLMVKCPNE--GCLHKMELRHLE---- -----------------------------------------------XX--X-XXXXXX- XXXXXX-------XXXXXXXXX----XXX----XXXXXXXXXXXXXXXXXXXXXXXXX-X --XXX------------------------------------------------------X XXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXX---X--XMXRN HLARHLQENT---XSXMRMLA--QAVHSLSL--------I----------------X--- -----------------------------------XSG--Y---------------ISEV RNFQEXIHQLEGR---LVRQXHQ------------------------------------- -----------------IRELTXK--------------------------METQ-----S MYVSELKRTIRTLEDKVA--E--XEAQQCN-GIYIWKIGNFGMHLKCQEEEKP--VVIHS PGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFV-HTMQGEYDSHLPWPFQGT---IRLT ILDQSEA----PVRQNHEEIMDAKP---ELLA-FQRP------------TIPR-NPKGFG YVTFMHLEALRQR---TFIKDDTLLVRCEVSTRFDM-----------------------G SLRREG--FQPRSTDAGV--- >A_gambiae_AGAP003004-PA ------------------------------------------------------------ -------------------------FLQSAAKADDGVLEARYECPICYCWLNE------- ----------PILTK--------CGHRFCRKCITDWL-------NEKN---SNCP---LD NEP----------LDIKCD--IFPDNCTRREISQIKKPCPNSMRGCGEQLSPTDID---- -----------------------------------------------TH--L-RQCPFA- MSRQ-------------------------------------------------------- ------------------------------------------------------------ -------------------------------------SQPCPFARVKCK---FV-APDEA AMSAHIASDC---QQHLQVAR--SPCVSALTVTKFEFSPF-------TICSYCSRRGSND RYKFWDPPAKNSVPEMSTN----------------------------------------- ----ELVRSMYER----------------------------------------------- -----------------IVILEQE--------------------------VHIL-----G IKLSKQEIQLTKLNQE-------VDPRYSG-GVLLWKLDDFSNKIESMVANSN--CMFYS SEAYTSPHGYKFCARINVS----PRTKDSIGLHV-HLMQSENDYHLEWPFKGR---IKIT LLNVRSP------ELSQHDTIMSKP---EILA-FHRP------------NQDI-SPRGFG FLEFAKIKDILA----KFADNNTVVIKIQMNIV--------------------------- --------------------- >D_rerio_ENSDARP00000040549 -----------------------------------------------------MAAEENE SSGLSRQNSEASRSWDL----------DSRTLRFVSRLEQQFICPSCGGIVLN------- ----------PHQTG--------CGHIFCAQCVKAYT-------ENGG--SSKCP---LD SIP----------I-KPEE--IFQDNCCKRELLNLEVFCTN-APECTQRFSLCNLQ---- -----------------------------------------------DH--L-KACPHE- RVRCSHS-----DCSDIVLRKN----LLE----HQRNACSYRLETCHYCRQNFPVSQMM- --GHQ-----------------------------------------------------KS SCPDVEVPCSNNCT--QMIKRHQLQAHAD-ECLEV--ETDCVYKNYGCT---V--RDKRG KVQVHENTEF---SAHVRLVL--ESNTKLEKQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >D_melanogaster_FBpp0074051 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MSLTKSS-------SRKD------------ -------------LTEQNQYQNQNENQNQPKSTTIVKYEKSSCLFCNEWFDAQTFT---- -----------------------------------------------EH--L-IHCGQV- LEECPN------GCQAFIPRIR----MRS----HLK-ECPRNQHNLSNQQRMSVSMDRLD --RQS-----------------------------------------------------DQ RLLVIEQDVGTIRSVLNEEIRQRLHLITDVGNIRKQNQVVEDWTRETEK---AMDDLRRQ MEEETNRKAFAIEQNQLDVQY---CCDITQSLKEQVESRL-------------------- ------DEAQKLVNQLSADVTYHQNQLNDNILKLEELI------------------FENE RLNREKFFQIEEF---LQQINEDIKTKLGNSDYVTSKQATLDYEVKNV------------ --------------KNIVCETEER--------------------------CDKL-----D RALHQTMQNISDLETQMAMQQRIASVQNIR-GHLIWRIKDYSKKLEESKQYDT---ILHS AMFSNKAFGYALRLDIYLNGKGTWK-GRNMIACL-NVLSGEYDPLLAWPCRLQ---AEII IRDQCTN------------VADAED---YVKTIFVRK------------KSD--DFIQSN QYFHIPHKVITSR---NYLRNDSMFIEVRVLK---------------------------- --------------------- >A_aegypti_AAEL015342-PA ------------------------------------------------------------ ------------------------------------------------------------ -----------------------MLYSFRRNLLIQVP-------H--------------- ---------------IHNLHLRTTDKITNPELTRLLTPC-----------SFPTFQ---- -----------------------------------------------SH--I-ADCGQV- LSKCPN------GCGVYVALKD----MDR----HLN-RCPAGFGEAP------------- --HQD-----------------------------------------------------GD RIRELELEIVGLRSTLNEEIRQRLALITDIGQLKKRTQLGDEWTAKVGD---VLNALKKC INEETDSRCVDVERCKLDINRLMREYERIEAWRLELTTRI-------------------- ------NRVGELAGRDEVDKPKDAKLVMIESRLNYLQT------------------EVET LREEQKDRKGDEK---AQEGNELVKGKIGVGDEQLDKQAKLDYELKGV------------ --------------LNTVNETEDK-------------------------SLEKY-----R RETYYTKQSLDDLQVHLQHQEKLVVIQNTE-GHLIWRIDQFEKRFEESQQSEF---MLKS PLFSNRPFGYTLRMEASLNGIGTWR-GRNMIVGL-VVVNGFYDNLLEWPCVLS---GTIT LRDQPQD--------------RAKPRVDYRRSIVARR------------KHQ--SN-DKN QNIHIPHQVLRSE---HYIRDDAIFLEVRIDQ---------------------------- --------------------- >A_aegypti_AAEL011363-PA ------------------------------------------------------------ ------------------------------------------------------------ ----------------------MIFYSFRRNLLIQIP-------H--------------- ---------------IHNLHLRTTDKITNPILTRLLTPC-----------SFSTFQ---- -----------------------------------------------SH--I-ADCGQV- LSKCPN------GCGVYVALKD----MDR----HLN-RCPAGFGEAP------------- --HQD-----------------------------------------------------GD RIRELELEIVGLRSTLNEEIRQRLALITDIGQLKKRTQLGDEWTAKVGD---VLNALKKC INEETDSRCVDVERCKLDINRLMREYERIEAWRLELTTRI-------------------- ------NRVGELAGRDEVDKPKDAKLVMIESRLNYLQT------------------EVET LREEQKDRKGDEK---AQEGNELVKGKIGVGDEQLDKQAKLDYELKGV------------ --------------LNTVNETEDS--------------------------LEKY-----R RETYYTKQSLDDLQVHLQHQEKLVVIQNTE-GHLIWRIDQFEKRFEESQQSEF---MLKS PLFSNRQFGYTLRMEASLNGIGTWR-GRNMIVGL-VVVNGFYDNLLEWPCVLS---GTIT LRDQPEV--------------RTKPRVDYRRSIVARR------------KHQ--SN-DKN QNIHIPHQVLRSE---HYIRDDAIFLEVRIDQ---------------------------- --------------------- >D_melanogaster_FBpp0071136 MQRVQADQKPARMHQHAHTHSHAHSLQHAEEKEHNSNEMTTNLSSTGRIAASSSATPSAA AGGGASGAPTPPKSLALNQNHHYAPGSDTSGEQEEELLDSRYECAICIDWLNE------- ----------PVLTS--------CGHRFCRSCLTAWM-------QKNN---QCCP---MD NKR----------LSAEHD--IFPDNYTRREIEQLKRDCPNSSLGCSVVASPIELH---- -----------------------------------------------RH--L-PSCPYR- RQQEPQ------------------------------------------------------ ------------------------------------------------------------ -------------------------------------EEKCPFAKIKCD---FVGRPETN QLEEHLKADM---PHHMQLML--QAFQQTAIATWQPHKPS---------TSGAAVENGHG QQQLPPPPQYANGVD--------------------------------------------- ---EQIVQTMYQR----------------------------------------------- -----------------IVVLEQR--------------------------TREQ-----E TRLENMQKQLRLARQQAP-----VDPRYSN-GTIVWRIEQLGALVARLRANAN--NQVYS HECYTSPHGYKFCARLNIQ----PRKPHVLSLHV-HLMQSENDYHLDWPFKGR---IKLC MVHPADA------TLSQHDTIMTKP---EILA-FHKP------------REAI-STRGFG FLEYANISNIIQL---GFCADDRLLIKIEINIV--------------------------- ---------------------