>H_sapiens_ENSP00000261233 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWR GL---------------------------AERL---------SSSWLDVRHIEKYVDQ-- -GKSGTRELLWSW-AQKNKTI------------------------------------GDL LQV----LQEMGHR---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAI HLITNYGAVLS-PSEKSYQEGGFPNILFK------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------ETANVTVDN---VLI--PEHNE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KGILLKSSISFQNIIEGTRN FH-----------------K------DFLIGEGEIFEVYRVEI------QNL--TYAVKL FKQE--KKMQ---CK--KHWKRFLS---ELEVLLL--FHHPNILELAAYFTET-EKFCLI YPYMRNGTLFDRL-QCVG-----DTAPLPWHIRIGILIGIS--KAIHYLH---NVQPCSV ICGSISSANILLDD--------QFQPKLTDFAMAHFRSH-----LEHQSC--TIN----- --------MTS-SSSKHLWYMPEEYI-RQGK--LSIKTDVYSFGIVIMEVLT-GCRVVLD DP----KHI--QLRDLLRE------LMEK--RGLDS------------------------ CLSFLDKK---------------VPPCP----RNFSAK-LFCLAG--RCAATRAKLRPSM D---------------------------------------------E-VLNTLESTQASL Y-FAEDPPTSLKSFRCPSPLFLENVP--------------------SIPVEDDESQNNNL LP---------------------------------------------------------- --SDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSSCEESWFPKYIV PSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >P_troglodytes_ENSPTRP00000008814 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWR GL---------------------------AERL---------SSSWLDVRHIEKYVDQ-- -GKSGTRELLWSW-AQKNKTI------------------------------------GDL LQV----LQEMGHR---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAI HLITNYGAVLS-PSEKSYQEGGFPNILFK------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------ETANVTVDN---VLI--PEHNE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KGILLKSSISFQNIIEGTRN FH-----------------K------DFLIGEGEIFEVYRVEI------QNL--TYAVKL FKQE--KKMQ---CK--KHWKRFLS---ELEVLLL--FRHPNILELAAYFTET-EKFCLV YPYMRNGTLFDRL-QCVG-----DTAPLPWHIRISILIGIS--KAIHYLH---NVQPCSV ICGSISSANILLDD--------QFQPKLTDFAMAHFRSH-----LEHQSC--TIN----- --------MTS-SSSKHLWYMPEEYI-RQGK--LSIKTDVYSFGIVIMEVLT-GCRVVLD DP----KHI--QLRDLLRE------LMEK--RGLDS------------------------ CLSFLDKK---------------VPPCP----RNFSAK-LFCLAG--WCAATRAKLRPSM D---------------------------------------------E-VLNTLESTQASL Y-FAEDPPTSLKSFRCPSPLFLENVP--------------------SIPVEDDESQNNNL LP---------------------------------------------------------- --SDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSSCEESWFPKYIV PSQDLRPYKVNMDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >M_mulatta_ENSMMUP00000021862 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MAGNCGVRGALSAHTLLFDLPPALLGELCAVLDSCDGALGWR GL---------------------------AERL---------SSSWLDVRHIEKYVDQ-- -GKSGTRELLWSW-AQKNKTI------------------------------------GDL LQV----LQEMGHR---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAI HLITNHGAVLS-PSEKSYQEGGFPNILLK------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------ETASVTVDN---VLI--PEHNG------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KGILPKSSISFQNIIEGTRN FH-----------------K------DFLIGEGEIFEVYRVEI------QNL--TYAVKL FKQE--KKMQ---CK--KHWKSFLS---ELEVLLL--FHHPNILELTAYFTET-EKFCLV YPYMRNGTLFDRL-QCVG-----DTAPLPWHVRISILIGIS--KAIHYLH---NVQPCSV ICGSISSANILLDD--------QFQPKLTDFAMAHFRSH-----VEHQSC--TIN----- --------MTS-SSSKHLWYMPEEYI-RQGK--LSIKTDVYSFGIVIMEVLT-GCRVVLD DP----KHI--QLRDLLIE------LMEK--RGLDS------------------------ CLSFLDKK---------------VPPCP----RNFSIK-LFCLAG--QCAATRAKLRPSM D---------------------------------------------E-VLNTLESTQASL Y-FAEDPPTSLKSFRCPSPLFLENVP--------------------SIPVEDDESQNNHL LS---------------------------------------------------------- --SDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSSREESWFPKYIV PSQDLRPFKVNMDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQHKKE------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >P_pygmaeus_ENSPPYP00000005399 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------AERL---------SSSWLDVRHIEKYVDQ-- -GKSGTRELLWSW-AQKNKTI------------------------------------GDL LQV----LQEMGHR---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAI HLITNYGAVLS-PSEKSYQEGGFPDILFK------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------ETANITVDN---VLI--PEHNE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KGILLKSSISFQNIIEGTRN FH-----------------K------DFLIGEGEIFEVYKVEI------QNL--TYAVKL FKQE--KKMQ---CK--KHWKRFLS---ELEVLLL--FRHPNILELAAYFTET-EKFCLV YPYMRNGTLFDRL-QCVG-----DTAPLPWHIRISILIGIS--KAIHYLH---NVQPCSV ICGSISSANILLDD--------QFQPKLTDFAMAHFRSH-----LEHQSC--TIN----- --------MTS-SSSKHLWYMPEEYI-RQGK--LSIKTDVYSFGIVIMEVLT-GCRVVLD DP----KHI--QLRDLLRE------LMEK--RGLDS------------------------ CLSFLDKK---------------VPPCP----RNFSAK-LFCLAG--RCAATRAKLRPSM D---------------------------------------------E-VLNTLESTQASL Y-FAEDPPTSLKSFRCPSPLFLENVP--------------------SIPVEDDESQNNNL LP---------------------------------------------------------- --SDEGPRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSSCEESWFPKYIV PSQDLRPYKVNMDPSSEAPGHSCRSRPVESSCSSKFSWDEYEHYKKE------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >G_gorilla_ENSGGOP00000006760 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWR GL---------------------------AERL---------SSSWLDVRHIEKYVDQ-- -GKSGTRELLWSW-AQKNKTI------------------------------------GDL LQV----LQEMGHR---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAI HLITNYGAVLS-PSEKSYQEGGFPNILFK------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------XXXXXXXXX---XXX--XXXXX------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------XXXXXXXXXXXXXXXXXXXX XX-----------------X------XXXXXXXXXXXXXXXXX------XXX--XXXXXX XXXE--KKMQ---CK--KHWKRFLS---ELEVLLL--FRHPNILELAAYFTET-EKFCLV YPYMRNGTLFDRL-QCVG-----DTAPLPWHIRISILIEIS--KAIHYLH---NVQPCSV ICGSISSANILLDD--------QFQPKLTDFAMAHFRSH-----LEHQSC--TIN----- --------MTS-SSSKHLWYMPEEYI-RQGK--LSIKTDVYSFGIVIMEVLT-GCRVVLD DP----KHI--QLRDLLRE------LMEK--RGLDS------------------------ CLSFLDKK---------------VPPCP----RNFSAK-LFCLAG--XCAATRAKLRPSM D---------------------------------------------E-VLNTLESTQASL Y-FAEDPPTSLKSFRCPSPLFLENVP--------------------SIPVEDDESQNNNL LP---------------------------------------------------------- --SDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSSCEESWFPKYIV PSQDLRPYEVNMDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >C_familiaris_ENSCAFP00000000535 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------AERL---------LSSWLDVRHIEKYVDQ-- -GKSGTRELLWSW-AQKNKTI------------------------------------GDL LQI----LQEMGHH---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAI HLIVNYGAALN-PSEQSHQRDGFPNMLPK------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------ETANVTTDN---VLT--PKHNE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KGILFKSSISFQNIRDGTKN FH-----------------K------DFLIGEGEIFEVYRAEI------QNR--TYAIKL FKQE--KKMQ---CK--KQWKRFLS---ELEVLLL--FHHPNILELAAYFTEN-EKFCLV YPYMRNGSLSDRL-QCVG-----NTAPLSWHIRISVLLGTA--RAIQYLH---NTEPCSV ICGSVSSANILLDD--------QFQPKLTDFGMAHFRPH-----LEHQSC--TIS----- --------VAS-SSSKHLWYMPEEYI-RQGK--LSIKTDVYSFGIVIMEVLT-GCKVVLD DP----KHI--QLRDLLME------LMEK--RGLDS------------------------ CLSFLDKK---------------VHPCP----RNFSAK-LFSLAG--QCATSRAKLRPSM D---------------------------------------------E-VLTTLESTQASL Y-FAEDPPTSLKSFRCPSPLFLENVP--------------------SIPVEDDENQNNHS LP---------------------------------------------------------- --HDKGLRKVGVTQKVPFECSQSEVTFLGFDRKTGSERNEDTCDRPSSSCKESGSPKHVA LSQDPGAYGTDVDPSVEAPGHSYRSRPVETSCSCEFSWNECEQYKRE------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >R_norvegicus_ENSRNOP00000005686 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MAGPCGARGTLSPHSLLFDLPPALLGELCTILDSCDGPLGWR GL---------------------------AERL---------SNSWLDVRHIEKYVHQ-- -GKSGTRELLWSW-AQKNKTI------------------------------------GDL LQV----LHEMGHQ---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAI HLIMNYGVNWT-PPVQTHHELRFPNLPPNSKPVCRESDPGP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------L-ELANVTVDN---VLV--PEHNE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RVVLHKTPISFQSILEGTKH FH-----------------K------DFLIGEGEIFEVYRVEI------RNQ--TYAVKL FKQE--KTMQ---LK--KHWKRFLS---ELEVLLL--FNHPHILELAAYFTEM-EKLCLV YPYMSNGTLFDRL-QCTN-----GTTPLSWHVRISVLIGIA--KAIQCLH---NTRPCAV ICGNISSANILLDD--------QFQPKLTDFAAAHFRPH-----LEQQSS--TIN----- --------MTG-SGRKHLWYMPEEYI-RQGR--LTIKTDVYSFGIVIMEVLT-GCKVVLD DP----KHV--QLRDLLME------LVEK--RGLDS------------------------ CLSFLDRK---------------IPPCP----RNFSAK-LFSLAG--QCVATRAKLRPTM D---------------------------------------------E-VLNTLESTQPSL Y-FAEDPPTSLKSFRCPSPLFLDNVP--------------------SIPVEDDENQNNYP VP---------------------------------------------------------- --PKEALRTDRVTQKTPFECSQSEVTFLGLDRNKGNRGSEAACNMPSSSCEECWCPELAE ASQDLRPTVISLGSSWEVPGYSYGSKPMEKRCSSGLFCSEHEQSKRQ------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >M_musculus_ENSMUSP00000020448 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MAGRCGARGALSPQLLLFDLPPALLGELCGILDSCDGPLGWR GL---------------------------AERL---------SNSWLDVRHIEKYVNQ-- -GKSGTRELLWSW-AQKNKTI------------------------------------GDL LEV----LQDMGHQ---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAI HLIINYGVSWT-PSVQTHHELPFPSFPPEVKHACRENDPGP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------L-EPANVTVDN---VLV--PEHNE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KGTLQKTPISFQSILEGTKH FH-----------------K------DFLIGEGEIFEVYRVDI------RNQ--AYAVKL FKQE--KKMQ---LK--KHWKRFLS---ELEVLLL--FRHPHILELAAYFTET-EKLCLV YPYMSNGTLFDRL-QCTN-----GTTPLSWHVRISVLIGIA--KAIQYLH---NTQPCAV ICGNVSSANILLDD--------QLQPKLTDFAAAHFRPN-----LEQQSS--TIN----- --------MTG-GGRKHLWYMPEEYI-RQGR--LSVKTDVYSFGIVIMEVLT-GCKVVLD DP----KHV--QLRDLLME------LMEK--RGLDS------------------------ CLSFLDRK---------------IPPCP----RNFSAK-LFSLAG--RCVATKAKLRPTM D---------------------------------------------E-VLSSLESTQPSL Y-FAEDPPTSLKSFRCPSPLFLDNVP--------------------SIPVEDDENQNNHS VP---------------------------------------------------------- --PKEVLGTDRVTQKTPFECSQSEVTFLGLDRNRGNRGSEADCNVPSSSHEECWSPELVA PSQDLSPTVISLGSSWEVPGHSYGSKPMEKRCSSGLFCSEHEQSKKQ------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >B_taurus_ENSBTAP00000033611 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------AERL---------SSSWLDVRHIEKYVDQ-- -GKSGTRELLWSW-AQKNKTI------------------------------------GDL LQI----LQEMGHH---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAI HLIANYGATLN-PIEQSHREKEFPNMLQKVECVCVDNDPCK------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------LEETANVTVDN---VLI--PERNE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KGILLKSSISFHSIVEGTKN FH-----------------K------DFLIGEGEIFEVYRVEI------QNR--TYAIKL FKQG--GKMQ---CK--KQWKRFLS---ELEVLLL--FRHPNILELAAYFTES-EKFCLV YPYMRNGSLFDRL-QCVG-----DTAPLSWHIRIGVLIGTS--KAIQYLH---NTELCSV ICGSISSANILLDD--------QFQPKLTDFAMAHFRPH-----LEPQSS--AIS----- --------MTS-SSSKHVWYMPEEYI-RQGK--LSIKTDIYSFGIVIMEVLT-GCKVVLD EP----KHI--QLRDLLIE------LMEK--RGLDS------------------------ CISFLDKK---------------VPPCP----QNFSAK-LFSLAG--RCAATRAKLRPSM D---------------------------------------------E-VLNILESTQASL Y-FAEDPPTSLKSFRSPSPLFFDNVP--------------------SIPVEDDENQNNPS PP---------------------------------------------------------- --HDQSLRKDRMTQKTPFECSQSEVTFLGFDKKTGSRGNEDSSSRSGSPCEESWSPKCAT PSLDLRAPSVHTDTSAEAPGHSYRSRPVETSCSSIFSWNECKLYKKASVSDEDKEESKNC ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >O_anatinus_ENSOANP00000009429 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------GSSGPVPAGTALLDLPPLLLGRLCALLDGAHGPLGWR DL---------------------------AERL---------SSNWLEVRHFEKYVQQ-- -GRSGTRELLWSW-AQKNKTV------------------------------------GDL LQV----LEDMGHQ---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAI DCLTNPGESLNISPSQTCQRDGFQSRASK------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------KTADSAVGN---EVLSPPKYQH------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------QGIRPKASIDFKSIIEGTGN FH-----------------G------DLLIGEGEFFQVYRMEF------ENQ--TYAIKL FKQE--KTMQ---SK--KYWKPFFS---ELEVLLL--FHHPNILELTAYFIEA-ERFCLV YPFMRHGSLFDRL-QCLG-----NTAPLSWKVRLGVLIGVA--RAIQVLH---SAKPCSV ISGSITSTNILLDD--------QFQPKLTDFATVHLQPQ-----TDCRSF--TVS----- --------TKS-NAAKHLWYMPEEYL-RQSR--LSTKTDVYSFGIIIMEVLT-GCKVVME EP----KHI--QLRDLLME------MMEK--RGLDS------------------------ CFSLLDKK---------------VEACP----RNFSAK-LLTLAG--QCATSRAKSRPSM D---------------------------------------------E-VLETLETTRPAL Y-FTEDPPASLRSFRPPSPLFLDLLP--------------------SVPVEDDENLPL-- ------------------------------------------------------------ --SGEEPNRHGVDRKTPLECSQSEVTFL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >M_domestica_ENSMODP00000011339 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------AERI---------SSSWLEVRHIEKYMEQ-- -GKSGTRELLWSW-AQKNKTI------------------------------------GDL LQI----LQEMGHE---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAI NLIVNHGRTISASTKQSQQSAGFPNIPSQ------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------VPTDSTIDK---QGE--MPEYR------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KEIRLKPSFNFKSIIEGTKN FH-----------------K------DLLIGEGEFFKVFRVEL------QNG--TYAVKL FKQE--TTIQ---NK--KNWKMFFS---ELEVLNLKSTHHPLYRETSYYHISV-PSFCSL FQLPPQISLYKKL-ENVG-D--DNTFPLSWQLRLSILIGAA--KAIQYLH---HVEPCSV ICGNITSSNILLDS--------QFQPKLTNFVTAHLRPH-----LEKQSS--TIN----- --------MES-SRNKYLLYMPEEYI-RQRR--LSIKTDVYSFGIVIMEVLT-GYQVVLE GP----KYV--RLRDLLVE------LMEK--RGLES------------------------ CLSLLDKK---------------ISPCP----QNFSWK-LFTLAN--QCASSRAKLRPTM D---------------------------------------------E-VLVALESSCPNL H-FTEDPPKSLKSFRSPSPLFLNHLP--------------------SVPMENDENQDFCS LP---------------------------------------------------------- ---NENLDKDGFAQKTPLECSQSEVTFLGLDRKALGKGKTPVSEVPVSSWEDNFSSNHLH PSQDSSVCVMNMYLSSES-GNPVLSKLVEPSSSSESYRNKNEEMEKM------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >O_cuniculus_ENSOCUP00000012468 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MAGRGGARGALSPHTLLFDLPPTLLGELCAVLDSCDGAMGWR GL---------------------------AERL---------SNSWLDVRLIEKYVDQ-- -GKSGTRELLWSC-AQKNKTI------------------------------------GDL LQI----LQEMGHH---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAI HLITNHXXXXX-XXXXXXXXXXXXXXXXX------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------XXXXXXXXX---XXX--XXXXX------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------XXMLLKSSISFQNVVEGTKN FH-----------------K------DFLIGEGEIFKVYRLEI------QNR--TYAVKL FKQE----------K--KQWKKFLS---ELEVLLL--XXXXXXXXXXXXXXXX-XXXXXX XXXXXXXXXXXXX-XXXG-----DTAPLSWDVRISILVGIS--RAILYLH---NIQPCSV ICGSISXXXXXXXX--------XXXXXXXXXXXXXXXXX-----XXXXXX--XXX----- --------XXX-XXXXXXXXXXXXXX-XXXX--XXXXXXXXXXXXXXXXXXX-XXXXXXX XX----XXX--XXXXXXXX------XXXX--XXXXX------------------------ XXXXXXXK---------------VSPCP----RNFSAK-LFSLAV--QCAATRAKLRPSM D---------------------------------------------E-VLNALESAQASL Y-FAEDPPMSLKSFRCPSPLFLDNVP--------------------SIPMEDDENQNHHS PP---------------------------------------------------------- --HDKSLQEDRMTEKTPFECSQSEVTFLGLDRNTGSKIPKDTFNTPIS-CEERWLPEHAV PSQDLGASEIHTSSSSDAPDHSCRSRPVGASCSSQVFLTKHEQYKNE------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >D_rerio_ENSDARP00000067130 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------VESS SSSVSERGMKHPNIITFTPGSTRNMSGNTEPSTLLFDVPPVLMESFCRLMDSGVDGLGWR TL---------------------------ASRI---------LSSQLEVRCIEMYAVA-- -GKSPTKELMWSW-AQRNKTV------------------------------------EDL LKV----LDEMGHA---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAR SLFQSQDSCVL-KSSSPPHYPTYLR----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------STGKSCQVSDLHAESVS VEGE-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------KQKCFITYFDVIEGTRH FH-----------------Q------DLKIGGSGFAEVYCGRW------GNR--SFAVKV FKQE--NKTD---WK--ALWEKFTK---EIEVLQL--NQHPNILELWGSFSDS-DRFCLV YPFLQNGSLFHRL-HEHV------DKPLSWQERLNIIKGTA--KAVHHLH---TSQPCTV ICGNITSSNILLDE--------NMQPKLCDFGLARLRPH-----SVDQSC--TIV----- --------MNT-ALHSNLGYLPEEYI-RDGK--LSVKLDVYSLGVVILETCT-GQKVKQE SS----KNL--FLRDVLHS------EVEE-KGCVDA------------------------ CLRFLDLK---------------FEHWP----PAVALC-LLRLGL--ECTGSKMRVRPDM E---------------------------------------------M-VLQRLIPLHPLP A-FSEDQPHTLDDTIPPQRPYK------------------------SFPIEDDEMHSQ-- ------------------------------------------------------------ --LEELHSPRVSKPADPCECSQSEVTFLSNEDRSFLRDCHQESDQRVSSSESVHSDSAAR LDLYGSWPVECSCSTETEAQACADCCANGFSQSVVYVTIDDDNALPAPNDARNPAKEKMK N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >G_aculeatus_ENSGACP00000025500 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------MDPNTFLYDVPPVVIERLCQILDSGVDRLGWR AL---------------------------AVRV---------VPSSLEVRMLERVEAA-- -GRSPTSELLWSW-AQENPRL------------------------------------LDL VKL----LQEMGHQ---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAL QLLQGPGSSSS-SSTSGPAIRTWS------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------NSTSLPAHSALHLPMTS AEE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------NKPPVITFQDIIDGTRN FH-----------------L------EMRISEGHFCDVYRAQI------GSE--KVAVKL FKQT--NMAS---WK--KLWDVFRK---EMEIHHM--YQHPNILDLLCCFTDA-GRYCLV YPYLADGSLFHRL-HHQD------REPLSWQQRLTIIKGTA--KALHHLH---TAQPCPV ICGSISSANILLGS--------NLQPKLSSFGIARLRPH-----SANQNS--TVT----- --------LDT-RSHSNLGYLSEEYI-RDGK--LSFSLDVYGFGMVIMETVT-GRKVTGE VS----KKT--PLRDLLVT------EVED-SGGVDS------------------------ CLQFLDET---------------AGCWP----TAVALD-LLRLAL--DCTASRHRSRPSM Q---------------------------------------------K-VLLALSKLLPPP SCLIADQPHSLDDPCDSKPSPPL-----------------------SIPVEHDEQLSPHA SPTRARLG---------------------------------------------------- ------------------ECSQSELTYLS--------------------------DAGGA VDLYSSWPVQCSCPAESGGLACEDCRANGFT----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >X_tropicalis_ENSXETP00000031192 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MSRGSFEEEFLYRVPSQVMYRFFHIMDS-LEETDWK KF---------------------------ASMI---------IPDMTELRLLEQ--QG-- -SRSRTEEVVWAW-SNRNAVV------------------------------------GEL LSI----LRSLNLL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAL DVFESWRSRYV-PESTQNFSQANPL-------PPPYP--YPGPESAPYFQKPQTKT---- DS---------LQTQ---------------------------ATN--PSDLPQQ------ ------------------------------------------LPL--------------- ------------------------------------------------------------ ------------------------------PGPPPKAFIC---SSH--SASTG------- -------GSS--DCS--------------------------------GSQIHSSVQESF- ----L------------------------------------------------------- ------------------------------------------------------------ ------------------------------------PSDVRDLPRQFVWRFQELVDGTRN FS-----------------Q------SLLIGEGGFGCVYKATM------RNT--EYAVKR LKQD--SELE---WS--TMKKSFLT---EIEKLTC--LRHPNIIDLAGYSFQG-EEYCLI YLYLPNGSLEDRL-HPQG----RF-PKLPMEQRISILQGAA--CGLQYLH---NYQP-SI IHGDVKSSNILLDQ--------AFMPKLGDFGLARFSRY--T-SNAGNSR--TLA----- --------RTS-TVKGTLAYLPEEYV-KMGK--LTFELDTYSFGVVLLENLT-GRKAIES DS--KSHTK--YLKDLVKEEECKDEEEEE-KGASMAS----------GAEAKLARVAARI CQYHLDFR---------------VWQHA----KEVTQE-LSQLAC--RCLGRQ-KKRPNM Q---------------------------------------------E-VFLTLKRLQEHL H--RRHLGKGHGISFTPPCVSTRRGFSPIHE-LASSVQDLP-----LTPEENTDKYTPCG LSVKGSVQ----------------------P----------YTPA--HTQHQAKVDSLCS SFSCQSLKTFRGAQNTPVESDESFPDFSGSDNSAGPSDQHILYPSG-------------- -------VQGSI--------------SPVLP-----RVSVQDP----------IPPVQYQ NQLAVQPRQRHYCNELSG------------------------------------------ ----------SGSSTSGASQGRPRGRATHFEEHVAALLVL-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >M_musculus_ENSMUSP00000033769 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------MAGGPGPGEPVVPGAQHFLYEVPPWVMCRFYKVMDA-LEPADWC QF---------------------------AALI---------VRDQTELRLCER------ -SEQRTASVLWPW-INRNARV------------------------------------ADL VHI----LTHLQLL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAR DIITAWHP----PAPVVPPSTAAPR-------PSSIS--AG---SEAGDWSPRKLQ---- SS---------ASTF---------------------------LSP--AFPGSQTHS---- ----------------------------------------E-SEL--------------- ------------------------------------------------------------ -----------------------------LQVPLPVSLGP---PLP--SSAPS------- -------STK--QSS----------------------------------------PESP- ----V------------------------------------------------------- ------------------------------------------------------------ ------------------------------------SGLQRAHPSPFCWPFCEISQGTCN FS-----------------E------ELRIGEGGFGCVYRAVM------RNT--TYAVKR LKEE--ADLE---WT--MVKQSFLT---EVEQLSR--FRHPNIVDFAGYCAES-GLYCLV YGFLPNGSLEDQL-HLQT----QACSPLSWPQRLDILLGTA--RAIQFLH---QDSP-SL IHGDIKSSNVLLDE--------RLMPKLGDFGLARFSRF--AGAKASQSS--TVA----- --------RTS-TVRGTLAYLPEEYI-KTGR--LAVDTDTFSFGVVILETLA-GQRAVRT QG---AKTK--YLKDLIED------EAEE-AGVTLKSTQPTLWVGV-ATDAWAAPIAAQI YKKHLDSR---------------PGPCP----PQLGLA-LAQLAC--CCMHRRAKKRPPM TQRQNSQHS------LLALWLYLGRCSVELSGKGLLLCWMSLRSQEQ-VYKRLEGLQAG- --------------------------PPWEL-EVAG--HGS-----PSPQENSYMSTT-G SAQ-SGDE----------------------P----------WQPL--VVTTRA------- --PAQAAQQLQRSPNQPVESDESVPGLSATLHSWHL---TPGSHPS-------P-----A SFREASCTQGGT------TRESSVRSSPGFQ-----PTTMEGS-----PTGSSSLLSSEP PQIIINPARQKMVQKLAL---YEEGVLD-------------------------------- -----SLQLLSSGFFPGLDLEPEKSQGPEESDEFQS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >M_mulatta_ENSMMUP00000026705 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------XNRNARV------------------------------------ADL VHI----LTHLQLL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAR DIITAWHP----PAPLPSPSTTAPR-------PSSIP--AP---AEAEAWSPRKLP---- SS---------ASTL---------------------------LSP--AFPGSQTHS---- ----------------------------------------G-PEL--------------- ------------------------------------------------------------ -----------------------------GLVPSPASLRP---PPP--SPAPS------- -------STK---PG----------------------------------------PESS- ----V------------------------------------------------------- ------------------------------------------------------------ ------------------------------------SLLQGAHPSPFCWPLCEISQGTHN FS-----------------E------ELKIGEGGFGCVYRAVM------RNT--VYAVKR LKED--ADLE---WT--AVKQSFLT---EVEQLSR--FRHPNIVDFAGYCAQN-GFYCLV YGFLPNGSLEDRL-HCQT----QACPPLSWPQRLDILLGTA--RAIQFLH---QDSP-SL IHGDIKSSNVLLDE--------RLTPKLGDFGLARFSRF--AGSSPSQSS--TVA----- --------RTR-TVRGTLAYLPEEYI-KTGR--LAVDTDTFSFGVVVLETLA-AQRAVKT HG---ARIK--YLKDLVEE------EAEE-AGVALRSTQST----L-AADSWAAPIAMQI CKKHLDPR---------------PGPCP----PELGLG-LGRLAC--CCLHRRAKRRPPM T---------------------------------------------Q-VYERLEKLQAVV ------------------------AGVPGHL-EAAS--CIP-----PSPQENSYVSST-G GAH-SGAA----------------------P----------WQPL--AAPSGA------- --SAQAAEQLQRGLNQPVESDESLGGLSAALRSWHL---TPSCPLG-------P-----A PLGEASCPQGDT------AGESSWGSGPGFR-----PTAVEGL-----VLGSSASSSSEP PQIIINPARQKMVQKLALQGFWQWGSLP-------------------------------- -----DLLSGLSSSF-GLGLE-QDRQGPEESDEFQS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >O_anatinus_ENSOANP00000017468 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------ASLI---------VRDQTELRLHER------ -TPARTASIMWPW-VNRNARV------------------------------------GDL IQI----LTDLQLL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAR DIITSCEL----PQPSARPNTNVPS-------RGRTW--AK---EGGWAFSPSPLP---- ES----------TSW---------------------------PPW--CFPGGSLQS---- ----------------------------------------K-PVL--------------- ------------------------------------------------------------ -------------------------------IPTPTSLHP---PPP--RPCPG------- -------RTD---PS--------------------------------VRFLQQKEERSC- ----F------------------------------------------------------- ------------------------------------------------------------ ------------------------------------SELAGGR-APFRWPFPEVSQGTRN FS-----------------E------QLKIGEGGFGCVYRATM------RNT--EYAVKK LKED--AELE---WS--VVKKSFVT---EVEKLSR--FRHPNIVDFAGYCVEG-GLYCLV YVFLPNGSLEDRL-HGQR----RSLAPLSWAQRVDILVGTA--RAIQFLH---RDNP-SL IHGDVKSSNILLDE--------KLTPKLGDFGLARFSRF--TGASSGRSS--SLA----- --------RTQ-TVRGTLAYLPEEYV-KTGK--LTVEIDTYSFGVVLLEILT-GRRAMES AGDGRSRAK--YLKDLVEE------EDVE-ADEPQKRNWPSTSGDISASDVRAAAVATRL YRKHLDSV---------------AGPCP----EELARE-LGQLAC--RCLHRRGKRRPLM T---------------------------------------------E-VYERLEKLQTRG ------------------------DQSYGQD-TGRS--KGP-----ASPQENSYMFTP-H CAPEDRVS----------------------G----------PQPL--Q--TKG------- --EAYLRGHFRPRPNQPVESDESVSDACAAVGSLSL---SYTSAQS-------P-----S PPGGPGGPTGGTPAAGSLAEPQSWGRGAPAAWGHNFPASVDSG------QGGSGDSLPVS HQIIINPARQKFVQKLAL---YKDGVLD-------------------------------- -----SLELLSSSSSPGLAPEPRTSKGPEESDDFQS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >P_pygmaeus_ENSPPYP00000023353 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDA-LEPADWC QF---------------------------AALI---------VRDQTELRLCER------ -SGQRTASVLWPW-INRNARV------------------------------------ADL VHI----LTHLQLL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAR DIITAWHP----PAPLPSPSTTAPR-------PSSIP--AP---AEAEAWSPRKLP---- SS---------ASTL---------------------------LSP--AFPGSQTHA---- ----------------------------------------G-PEL--------------- ------------------------------------------------------------ -----------------------------GVVPSPASLRP---PPP--SPAPS------- -------STK---PG----------------------------------------PESS- ----V------------------------------------------------------- ------------------------------------------------------------ ------------------------------------SLLQGAHPSPFCWPLCEISQGTHN FS-----------------E------ELKIGEGGFGCVYRAVM------RNT--VYAVKR LKED--ADLE---WT--AVKQSFLT---EVEQLSR--FRHPNIVDFAGYCAQS-GFYCVV YGFLPNGSLEDRL-HCRT----QACPPLSWPQRLDILLGTA--RAIQFLH---QDSP-SL IHGDIKSSNVLLDE--------RLTPKLGDFGLARFSRF--AGSSPSQSS--MVA----- --------RTQ-TVRGTLAYLPEEYI-KTGR--LAVDTDTFSFGVVVLETLA-GQRAVKT HG---ARTK--YLKDLVEE------EAEE-AGVALRSTQSTLQAGL-AADAWAVPIAMQI YKKHLDPR---------------PGPCP----PELGLG-LGRLAC--CCLHRRAKRRPPM T----------------------------------------------------------- -------------------------------------------------QENSYVSST-G SAH-SGAA----------------------P----------WQPP--AAPSGA------- --SAQAAEHLQRGPNQPVESDESLGGLSAALRSWHL---TPSCPLD-------P-----A PLREAGCPQGDM------AGESSWGSGPGFR-----PTAVEGL-----ALGSSASSSSEP PQIIINPARQKMVQKLAL---YEDGALD-------------------------------- -----SLQLLSSSSLPGLGLE-QDRQGPEESDEFQS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >H_sapiens_ENSP00000358997 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDA-LEPADWC QF---------------------------AALI---------VRDQTELRLCER------ -SGQRTASVLWPW-INRNARV------------------------------------ADL VHI----LTHLQLL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAR DIITAWHP----PAPLPSPGTTAPR-------PSSIP--AP---AEAEAWSPRKLP---- SS---------ASTF---------------------------LSP--AFPGSQTHS---- ----------------------------------------G-PEL--------------- ------------------------------------------------------------ -----------------------------GLVPSPASLWP---PPP--SPAPS------- -------STK---PG----------------------------------------PESS- ----V------------------------------------------------------- ------------------------------------------------------------ ------------------------------------SLLQGARPFPFCWPLCEISRGTHN FS-----------------E------ELKIGEGGFGCVYRAVM------RNT--VYAVKR LKEN--ADLE---WT--AVKQSFLT---EVEQLSR--FRHPNIVDFAGYCAQN-GFYCLV YGFLPNGSLEDRL-HCQT----QACPPLSWPQRLDILLGTA--RAIQFLH---QDSP-SL IHGDIKSSNVLLDE--------RLTPKLGDFGLARFSRF--AGSSPSQSS--MVA----- --------RTQ-TVRGTLAYLPEEYI-KTGR--LAVDTDTFSFGVVVLETLA-GQRAVKT HG---ARTK--YLKDLVEE------EAEE-AGVALRSTQSTLQAGL-AADAWAAPIAMQI YKKHLDPR---------------PGPCP----PELGLG-LGQLAC--CCLHRRAKRRPPM T---------------------------------------------Q-VYERLEKLQAVV ------------------------AGVPGHS-EAAS--CIP-----PSPQENSYVSST-G RAH-SGAA----------------------P----------WQPL--AAPSGA------- --SAQAAEQLQRGPNQPVESDESLGGLSAALRSWHL---TPSCPLD-------P-----A PLREAGCPQGDT------AGESSWGSGPGSR-----PTAVEGL-----ALGSSASSSSEP PQIIINPARQKMVQKLAL---YEDGALD-------------------------------- -----SLQLLSSSSLPGLGLE-QDRQGPEESDEFQS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >C_familiaris_ENSCAFP00000028744 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------MAGGPGPGDPAAPGAQHFLYEVPPWVMCRFYKVMDA-LEPADWC QFGGWRRAGDAGAGGARAPGAGPDACRPAAALI---------VRDQTELRLCER------ -SGQRTASVLWPW-INRNARV------------------------------------ADL VSI----LTHLQLL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAR DIITAWHP----PAPLLPPSTSAPR-------PSSPP--AP---CEADVPRPRKLP---T AS---------ASTL---------------------------PSP--AFPGSQTHS---- ----------------------------------------G-AEL--------------- ------------------------------------------------------------ -----------------------------GPVHSPGILQP---PPP--RPAPS------- -------STK---PS----------------------------------------AESP- ----A------------------------------------------------------- ------------------------------------------------------------ ------------------------------------SLLQGAHPSPFCWPLSEISQGTHN FS-----------------D------KLKIGEGGFGCVYRAVM------RNT--LYAVKR LKEG--ADLE---WT--TVKQSFLT---EVEQLSR--FRHPNIVDFAGYCAES-GFYCLV YGFLPNGSLEDRL-HFQT----EACAPLSWPQRLNILLGTA--RAIQFLH---QDSP-SL IHGDIKSSNVLLDD--------RLMPKLGDFGLARLSRF--AGANPGQSS--TVA----- --------RTR-TVRGTLAYLPEEYV-KTGR--LAVDTDTFSFGVVVLETLA-GQRAVRT QG---AKTK--YLKDLVEE------EAEE-AGVTLRSTQSTLQAGL-ATDAWAAPIASQI CKKHLDPR---------------PGPCP----PELGLV-LGQLAC--CCLHRRAKRRPPM T----------------------------------------------------------- -------------------------------------------------QENSYVSVP-S ----SGAS----------------------P----------RQPL--AAPSGA------- --PAQATEWLQKGPNQPVESDESVSGLSAALCSWHM---SPSCP---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >G_gorilla_ENSGGOP00000000218 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------MAGGPGPGESAAPGAQHFLYEVPPWVMCRFYKVMDA-LEPADWX XX---------------------------XXXX---------XXXXXXXXXXXX------ -XXXXXXXXXXXX-XXXXXXX------------------------------------XXX XXX----XXXXXXX---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------XXX XXXXXXHP----PAPLPSPSTTAPR-------PSSIP--AP---AEAEAWSPRKLP---- SL---------ASTL---------------------------LSP--AFPGSQTHS---- ----------------------------------------G-PEL--------------- ------------------------------------------------------------ -----------------------------GLVPSPASLWP---PPP--SPAPS------- -------STK---PG----------------------------------------PESS- ----V------------------------------------------------------- ------------------------------------------------------------ ------------------------------------SLLQGARPSPFCWPLCEISRGTHN FS-----------------E------ELKIGEGGFGCVYRAVM------RNT--VYAVKR LKED--ADLE---WT--AVKQSFLT---EVEQLSR--FRHPNIVDFAGYCAQN-GFYCLV YGFLPNGSLEDRL-HCQT----QACPPLSWPQRLDILLGTA--RAIQFLH---QDSP-SL IHGDIKSSNVLLDE--------RLTPKLGDFGLARFSRF--AGSSPSQSS--MVA----- --------RTQ-TVRGTLAYLPEEYI-KTGR--LAVDTDTFSFGVVVLETLT-GQRAVKT HG---ARTK--YLKDLVEE------EAEE-AGVALRSTQSTLQAGV-AADAWAAPIAMQI YKKHLDPR---------------PGPCP----PELGLG-LGQLAC--CCLHRRAKRRPPM T---------------------------------------------Q-VYERLEKLQAVV ------------------------AGVPGHS-EAAS--CIP-----PSPQENSYVSST-G SAH-SGAA----------------------P----------WQPL--AAPSGA------- --SAQAAEQLQRGPNQPVESDESLGGLSAALRSWHL---TPSCPLD-------P-----A PLREAGXPQGAT------AGESSWGSGPGSR-----PTAVE------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >R_norvegicus_ENSRNOP00000053167 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------MDA-LEPADWC QF---------------------------AALI---------VRDQTELRLCER------ -SEQRTASVLWPW-INRNARV------------------------------------ADL VHI----LTHLQLL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAR DIITAWHP----PASVLPPSTGAPR-------PSSIS--AG---SETEDWSPRKLQ---- SS---------ASTF---------------------------LSP--AFPGSQTHS---- ----------------------------------------E-SEL--------------- ------------------------------------------------------------ -----------------------------LQVPLSDSLGP---PLQ--SSAPS------- -------SIK--QPS----------------------------------------PESP- ----V------------------------------------------------------- ------------------------------------------------------------ ------------------------------------SGLQRARPSPFCWPFCEISQGTCN FS-----------------E------ELRIGEGGFGCVYRAVM------RNT--TYAVKR LKEE--ADLE---WT--VVKQSFLT---EVEQLSR--FRHPNIVDFAGYCAES-GFYCLV YGFLPNGSLEDQL-HLQT----QACSPLSWPQRLDILLGTA--RAIQFLH---QDSP-SL IHGDIKSSNVLLDE--------RLMPKLGDFGLARFSRF--AGANPSQSS--TVA----- --------RTC-TVRGTLAYLPEEYI-KTGR--LAVDTDTFSFGVVILETLA-GQRAVRT QG---AKTK--YLKDLIED------EAEE-VGVTLKSTQPTLWMGV-ATDAWTAPIAAQI YKKHLDSR---------------PGPCP----PQLGLA-LAQLAC--CCMHRRAKKRPPM TQRQNSQ-S------LLPLWLCLGRRSLELSGKGLLLCWVGLRSQEQ-VYKRLEGLQAV- --------------------------PPWKL-EVAG--HGS-----PSPQENSYMSTT-G SAQ-SGDE----------------------P----------WQPL--VVTTRA------- --PAQAAQQLQRSPNQPVESDESVPGLSATLHSWHL---TPDSHPS-------P-----V SFREASCTQGGT------TRESSLRSGPGFQ-----PTTMEGS-----SMGSSSLLSSEP PQIIINPARQKMVQKLAL---YEEGVLD-------------------------------- -----SLQLLSSGFFPGLDLEPEKRKRPEESDEFQS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >E_caballus_ENSECAP00000007763 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MCRFYKVMDA-LEPADWC QF---------------------------AALI---------VRDQTELRLCER------ --SQRTASV-WPW-INRNARV------------------------------------ADL VRI----LTHLQLL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAR DIITAWHP----PAPNKPPSTTALK-------PSSLS--AP---SEAEALSPRKLQ---- SS---------ASTL---------------------------LSP--AFPGSQTHS---- ----------------------------------------G-PEL--------------- ------------------------------------------------------------ -----------------------------GPVPSLAALRP---PPA--SPAPS------- -------STK---QS----------------------------------------PESQ- ----L------------------------------------------------------- ------------------------------------------------------------ ------------------------------------SLLQGAHPSPFCWPLHEISRGTHN FS-----------------E------ELKIGEGGFGCVYRAVM------RNT--VYAVKR LKEE--ADLE---WT--TVKQSFLT---EVEQLSR--FRHPNIVDFAGYCAQT-GCYCLV YGFLPNGSLEDRL-HFQT----QACPPLSWPQRLDILLGTA--RAIQFLH---QDSP-SL IHGDIKSSNVLLDE--------RLMPKLGDFGLARLSRF--AGANPSQSS--TVA----- --------RTR-TVRGTLAYLPEEYV-KTGR--LAVDTDTFSFGVVVLESLV-GQRAVRT HG---ARTK--YLKDLVEE------EAEE-AGVALKSTQTAIKAGL-ATDAWAAPIATQI YKKHLDPR---------------PGPCP----PELGLA-LGQLAC--CCLHRRAKRRPPM T---------------------------------------------Q-VYERLEKLQVAV ------------------------TGLSLEP-EAAS--HSP-----PSPQENSYVSTA-S SAL-SSTS----------------------L----------RPPL--AVPSGA------- --PAQTTERLQKGPNQPVESDESVSSLSAALHSWHL---TLSCPPA-------P-----A LLGQAGCTQGGT------ARESSWGSGPGTR-----PTAVEGS-------WAALRHRSHR RLLSTRPGRR-------------------------------------------------- ----------WCRSWPCMRMGSWTAYSCYHQAPSQA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >B_taurus_ENSBTAP00000021407 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------AALI---------VRDQTELRLCER------ -SGQRTASVLWPW-INRNARV------------------------------------ADL VRI----LTHLQLL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAR DIITAWHP----PAPLLPPSTTSLT-------PSSIS--AP---SEAAVPGHRKLP---- SL---------ASTF---------------------------LSP--AFPGSQTHS---- ----------------------------------------D-PEL--------------- ------------------------------------------------------------ -----------------------------CPGPSPAAHQP---PLP--SPAPS------- -------STK---PS----------------------------------------PESP- ----M------------------------------------------------------- ------------------------------------------------------------ ------------------------------------SLLPGAPSSSFCWPLHEICQGTHD FS-----------------E------ELKIGEGGFGCVYRAVM------RNT--VYAVKR LKEE--ADLE---WT--TVKQSFQT---EVQQLSR--FRHPNIVDFAGYCAQS-GFYCLV YGFLPNGSLEDRL-HVQT----QAWPPLSWPQRLDILLGTA--RAIQFLH---QDSP-SL IHGDVKSSNVLLDE--------RLMPKLGDFGLARLSRF--TGANPGQSS--SVA----- --------RTR-TVRGTLAYLPEEYV-KTGR--LAVDTDTFSFGVVLLETLA-GQRAVRM HG---AQPK--YLKDLVEE------EAEE-AGVTLKGTQTAVQGGP-AADTWAALVAAQI YKKHLDPR---------------PGPCP----PQLGLA-LGQLAC--CCLHRRAKRRPPM T---------------------------------------------Q-VYQTLEELQVVV ------------------------AGPCLEL-EAAS--RSP-----PSPQENSYVSTS-G SAL-SRAS----------------------P----------WQPL--AAPLGA------- --QAQATDWPQKGANQPVESDESVSDLSAALHSWHL---SPSCPAGPGAPSWVP-----A PFGQAACTQGGA------ARESSCGSGPGLQ-----PTAVEGP-----LLGSS--MSSRP PQIVINPARRKMLQKLAL---YEDGVLD-------------------------------- -----SLQLLSSSSLPDSGQDLQDRQGPEERDEFRS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >D_rerio_ENSDARP00000092301 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------LLYNLSASVMNDFTRVMDS-LSNSDWI SF---------------------------ASQI---------ISDQTELRLLEQ------ -SPRRTSNLMHNW-GCRNGTV------------------------------------GAL LKI----LEGLQWF---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAR DIILKAQL-YF-PRSYLVYLFTACD-------PSIIY--LY---SRQFPQNHKEQQ---- PS---------TVTF---------------------------IKEHLPVPGNMF------ ------------------------------------------PEI--------------- ------------------------------------------------------------ -----------------------------RPLPRPS---P---PPP--DSVSS------- -------TIS--KTT----------------------------------------EEVF- ----C------------------------------------------------------- ------------------------------------------------------------ ------------------------------------LNPPPLSSSAMSWPFEEIQRGTCN FS-----------------P------CKQIGEGGFGHVYKAVM------RNT--EFAVKK LKED--SHLD---WN--VVKESFRT---EVDKLSQ--YRHPNIMDFVGYCISG-QTYCVI YVYMPNGSLDDRL-RNEV----ICINALSWSQRVNVLLGTA--KAIQYLH---SCSP-AL IHGDIKSSNILLGD--------HLEPKLGDFGLARLCRN--PNKTPGKTS--TVA----- --------QTA-TVRGTLAYLPEEYL-KDGQ--LGVEIDAYSFGVVMLEVLT-GRQALEV DS--QSKTV--FLKDLVTE------EEDD-GRSFSKAKH--------SRDLSYGQTAEHI CKKHLDRRLT-------------AKDAP----ATHGSADIARLAC--QCLERRRKKRPRM T---------------------------------------------D-VFKALQDVHSGL K--ISDRSTTINKSPVA-------TPEPLRS-DSSSIDSLSHHFSKLRPQEDTYPCV--- -----------------------------------------HKPVFHTLTTTVTTESGCS VSQLNEESWASQSSGVPCESDES-QGFSQYLTSHCSRSKSVSCGAQ-------------- --------------------------------------GIEST------KTDISSVEKQP QNVIINPARQRLVQKMEL---YEEGRIL-------------------------------- -----TSDLLSSGASLYRGMSAQTRE-PEESDEFAS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >M_domestica_ENSMODP00000037830 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------MDS-LESADWH KF---------------------------ASLI---------VQDQTELRLGER------ -FHDRTARIMWSW-INRNARV------------------------------------ADL LHI----LTSLQLR---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SGP GHRDPEPP----SLPPAAPSTCTPTPPWPPPQPKPQS--GP---KE-EGARPREAC---- QS---------FSTF---------------------------PSP--GFPSDSWPS---- ----------------------------------------PCPPS--------------- ------------------------------------------------------------ -----------------------------SPAPQRAA-GP---LSS--NTSSS------- -------STK---QG----------------------------------------EENK- ----I------------------------------------------------------- ------------------------------------------------------------ ------------------------------------SPVEYASPPPFRWPLLEITQATHN FS-----------------E------ELKIGEGGFGCVYRAVM------RNT--SYAVKR LKED--AELE---WN--TIKTSFGT---EVEKLSR--FRHPNIVDFAGYCIQD-NVYCLV YVFLPNGSLEDQL-HSQN----QNPSLLSWAQRVDILLGTA--RAIQFLH---QDNP-SL IHGDVKSSNILLDE--------KLVPKLGDFGLARFSRY--SGAASGKSS--SLA----- --------RTQ-TVRGTLAYLPEEYV-KTGK--LTVEIDTFSFGVVLLEILT-GCRAIET DG---ARTK--YLKDLVEE------EEEE-TLASCKGMATG--AGV-DLEARAAQIGSRL YAKYTDSR---------------PGKCP----PELGQE-LGRLAC--RCLHRRGKRRPPM TKVQMAPGAEGGPGVRPALGALLAVCSRALPQAPLSFLILLMPPERK-IYESLEKLQASV ------------------------G--PSER-EAGS--RGP-----ASPQEDSYMFTP-N SAP-DGGT----------------------PLLHSQARAWHRQPP--HSSHGS------- --RAQDSKQLWNHPNQPVESDESTPGLCDVLNSWNLNQNSPSVPSLPGGPGERPEAQALC SLRQTSCQPEAA------ASGESWGKS----------------------------DTSER PQIIINPARQRFVQKLAL---YENGVLN-------------------------------- -----SLELLSSSSSPGLGLDQGNKQGPEESDEYQS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >P_troglodytes_ENSPTRP00000038647 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------MAGGPGP------------------------------------- ----------------------------------------------TELRLCER------ -SGQRTASVLWPW-INRNARV------------------------------------ADL VHI----LTHLQLL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAR DIITAWHP----PALLPSPSTTAPR-------PSSIP--AP---AEAEAWSPRKLP---- SS---------ASTL---------------------------LSP--AFPGSQTHS---- ----------------------------------------G-PEL--------------- ------------------------------------------------------------ -----------------------------GLVPSPASLWP---PPP--SPAPS------- -------STK---PG----------------------------------------PESS- ----V------------------------------------------------------- ------------------------------------------------------------ ------------------------------------SLLQGARPSPFCWPLCEISRGTHN FS-----------------E------ELKIGEGGFGCVYRAVM------RNT--VYAVKR LKED--ADLE---WT--AVKQSFLT---EVEQLSR--FRHPNIVDFAGYCAQN-GFYCLV YGFLPNGSLEDRL-HCQ----------------------TA--RAIQFLH---QDSP-SL IHGDIKSSNVLLDE--------RLTPKLGDFGLARFSRF--AGSSPSQSS--MVA----- --------RTQ-TVRGTLAYLPEEYI-KTGR--LAVDTDTFSFGVVVLETLA-GQRAVKT HG---ARTK--YLKDLVEE------EAEE-AGVALRSTQSTLHAGL-AADAWAAPIAMQI YKKHLDPR---------------PGPCP----PELGLG-LGQLAC--CCLHRRAKRRPPM T---------------------------------------------Q-VYERLEKLQAVV ------------------------AGVPGHS-EAAS--CIP-----PSPQENSYVSST-G SAH-SGAA----------------------P----------WQPL--AAPSGA------- --SAQAAEQLQRGPNQPVESDESLGGLSAALRSWHL---TPSCPLD-------P-----A PLREAGCPQGDT------AGESSWGSGPGSR-----PTAVEGL-----ALGSSASSSSEP PQIIINPARQKMVQKLAL---YEDGALD-------------------------------- -----SLQLLSSSSLP-------------ESDEFQS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >R_norvegicus_ENSRNOP00000007932 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MSKPLTPSTYVRSLNVGILRKLSDFIDP---QEGWK KL---------------------------AVAIKKPSGDD--RYNQFHIRRFEALLQT-- -GKSPTCELLFDW-GTTNCTV------------------------------------GDL VDL----LIQIELF---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------APA TLLLPDAVPQAVHS---LPPR-EAATVAQ---------------AHRPCQEKNRTTVTPA LAQKL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------EPSCELPDSSS---PGHQSVEFSD------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TRFHSFSFYELKSITND FD-----------------ERPVSIGGNRMGEGGFGVVYKGCV------NNT--TVAVKK LGAM--VEIS---TE--ELKQQFDQ---EIKVMAK--CQHENLVELLGFSSDS-DNLCLV YAYMPNGSLLDRL-SCLD-----GTPPLSWHMRCKIARGAA--NGIRFLH---EN---HH IHRDIKSANILLDQ--------DFTAKISDFGLARASAK--------LAQ---TV----- --------MTS-RIVGTTAYMAPEAL-R-GE--ITPKSDIYSFGVVLLELIT-GLAAVDE NR----EPQ--LLLDIKEE------IEDK----------------------------EKT IEDCTDEK---------------MSDAD----PASVEA-MYSVAS--QCLHEKKNRRPDI A---------------------------------------------K-VQQLLQETSA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >E_caballus_ENSECAP00000012782 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MNKPITPSTYVRCLNLGLIRKLSDFIDP---QEGWK KL---------------------------AVAIKKPSGDD--RYNQFHIRRFEALLQT-- -GKSPTCELLFDW-GTTNCTV------------------------------------GDL VDL----LVQNEFF---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------APA SLLLPDAVPKTVNI---LPSK-EAITIQQ---------------KQIPLYGKDRTSVIP- -VQNP------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------EQNYVPPDSSS---PENGSLEVSD------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TRFHCFSFYELKNVTNN FD-----------------ERPVSIGGNKMGEGGFGVVYKGYV------NNR--MVAVKK LAAM--VDIS---TE--ELKQQFDQ---EIKVMAK--CQHENLVELLGFSSDG-DDLCLV YVYMPNGSLLDRL-SCLD-----DTPPLSWHMRCKIAHGAA--NGISFLH---EN---HH IHRDIKSANILLDE--------AFTAKISDFGLARASER--------FTQ---TV----- --------MTS-RIMGTTAYMAPEAL-R-GE--ITPKSDIYSFGVVLLEIIT-GLPAVDE HR----EPQ--LLLDIKDE------IEDE----------------------------EKT IEDYIDKK---------------MNDID----STSVET-MYSVAS--QCLHEKKNKRPDI K---------------------------------------------K-VQQLLQEMTTS- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >A_carolinensis_ENSACAP00000012253 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------FLYELPASVMCHFYEIMDA-LGREEWQ RF---------------------------ASRI---------VRDQVELRLYER------ -MEAPTSKVMWAW-MNRNARV------------------------------------SDL LQI----LDDLQLY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAH NVIASCES----ACSVSSTSTSPPL-------SLCLS--LF---FSKRDKDPERKW---- SP---------SQTQ---------------------------ESP--PSPGSQGAA---- ----------------------------------------G-APL--------------- ------------------------------------------------------------ -----------------------------RLGTTPMAYWQ---QTL--CGQSS------- -------SSS---SS----------------------------------------SSSS- ----R------------------------------------------------------- ------------------------------------------------------------ ------------------------------------LGSSLSLTCPFEWRLEELRQATSD FS-----------------E------NLKIGEGGFGCVYQARL------RNT--IYAVKR LKEE--AELD---WS--VIKNSFVT---EVEKLYR--FRHPNIVELAGYCAEQ-GNFCLV YVFLPKGSLDDHL-HRQV----GPC--LTWSQRLHVAVGTS--RAIQFLH---SDSP-SL IHGDVKSSNILLDA--------ALNPRLADFGLARFSRR--PKQGT-MSS--SLG----- --------RTQ-TVQGTLAYLPPEYV-RTGT--LSTAIDVFSFGV--------------- -------------KDLLSE------EEEA-QHTPTTMT---------SSSSQAAQLGTSL YQKHMDLQ---------------AGPCP----ELLGIM-IGRLAC--QCLHPRAKRRPPM A---------------------------------------------E-VYQELERLQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >H_sapiens_ENSP00000349096 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MNKPITPSTYVRCLNVGLIRKLSDFIDP---QEGWK KL---------------------------AVAIKKPSGDD--RYNQFHIRRFEALLQT-- -GKSPTSELLFDW-GTTNCTV------------------------------------GDL VDL----LIQNEFF---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------APA SLLLPDAVPKTANT---LPSK-EAITVQQ---------------KQMPFCDKDRTLMTP- -VQNL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------EQSYMPPDSSS---PENKSLEVSD------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TRFHSFSFYELKNVTNN FD-----------------ERPISVGGNKMGEGGFGVVYKGYV------NNT--TVAVKK LAAM--VDIT---TE--ELKQQFDQ---EIKVMAK--CQHENLVELLGFSSDG-DDLCLV YVYMPNGSLLDRL-SCLD-----GTPPLSWHMRCKIAQGAA--NGINFLH---EN---HH IHRDIKSANILLDE--------AFTAKISDFGLARASEK--------FAQ---TV----- --------MTS-RIVGTTAYMAPEAL-R-GE--ITPKSDIYSFGVVLLEIIT-GLPAVDE HR----EPQ--LLLDIKEE------IEDE----------------------------EKT IEDYIDKK---------------MNDAD----STSVEA-MYSVAS--QCLHEKKNKRPDI K---------------------------------------------K-VQQLLQEMTAS- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >P_troglodytes_ENSPTRP00000008285 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MNKPITPSTYVRCLNVGLIRKLSDFIDP---QEGWK KL---------------------------AVAIKKPSGDD--RYNQFHIRRFEALLQT-- -GKSPTSELLFDW-GTTNCTV------------------------------------GDL VDL----LIQNEFF---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------APA SLLLPDAVPKTANT---LPSK-EAVTVQQ---------------KQMPFYDKDRTLMTP- -VQNL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------EQSYMPPDSSS---PENKSLEVSD------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TRFHSFSFYELKNVTNN FD-----------------ERPISVGGNKMGEGGFGVVYKGYV------NNT--TVAVKK LAAM--VDIT---TE--ELKQQFDQ---EIKVMAK--CQHENLVELLGFSSDG-DDLCLV YVYMPNGSLLDRL-SCLD-----GTPPLSWHMRCKIAQGAA--NGINFLH---EN---HH IHRDIKSANILLDE--------AFTAKISDFGLARASEK--------FAQ---TV----- --------MTS-RIVGTTAYMAPEAL-R-GE--ITPKSDIYSFGVVLLEIIT-GLPAVDE HR----EPQ--LLLDIKEE------IEDE----------------------------EKT IEDYIDKK---------------MNDAD----STSVET-MYSVAS--ECLHEKKNKRPDI K---------------------------------------------K-VQQLLQEMTAS- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_rubripes_ENSTRUP00000016336 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------LTGLGPDCGHTQRPQSG----DQFLYDLPPRVLWEFCRVMDA-LSDLDWT RF---------------------------ASMV---------LDDQTALRLAQK------ -QEKRTDWVMNQW-EIRNGRV------------------------------------GEL VNL----LEGLELL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RPR DVILLKPP----PPPAPAAPPTAPA-------APRVP--SP---PFNTV----------W SK---------RSSP---------------------------RPA--ALNVSLLVP---- ----------------------------------------RASTV--------------- ------------------------------------------------------------ -----------------------------AQQCIDATPQP---SIM--YG-PE------- -------THQ---GC----------------------------------------PNFL- ----Q------------------------------------------------------- ------------------------------------------------------------ ------------------------------------RGPDLITSGLMCWSYEEVHAGTKG FS-----------------P------TLQVGEGGFGVVYKATL------SNT--VCAVKV LKED--RLLD---WK--VLNQSFQT---EMEKLSK--FRHPNIVDLLGFSKGP-GTVCLI YSYMENKSLEHKL-HNGD----QQSSYLSWSQRVSVVTEAS--TALQFLHSPPSGNT-PL IHGDVKSSNILLDH--------HMTAKLGDFGLARFAPR----PSPSETK--PLG----- --------RTT-TIRGTLAYLPHEYV-RTGK--LGTVVDVYSFGVVLLEVLT-GRRALEE DQ--DLGQK--YLKDLVEE------IRESPSGSPEES----------------------- WRKQLDHRLLAVTWSRSTAAVSAEGATE----PAGWME-MVALAC--RCLANNRKGRPAM A---------------------------------------------E-VFDKLQDINTLV ------------------------KRSSPHM-DLSGACL---SKEPAQSSQSSSCSSSCS LQSPHRLR----------------------S----------------PSSHVS------- --SSSSCSPSPSSFAGPCETDESRGFSHPCLQSGHLSQVGPATFWGLVKVGLKAEHPSGG AACGPGPASASR------------------------DRYTVYLCVRACVCACVCVCA--- --VLMNPSKQHLLQKKTL---YEEGRIE-------------------------------- -----TPELLSSEDIYG-GTSSVALTGPEESDEQDW------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >M_domestica_ENSMODP00000023115 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MNKTVTSSTYVRCLNVGLIRQLADFIDP---QEGWK KL---------------------------AVDIKKPSGEN--RYNQFHIRRFEGLLQN-- -GKSPTSELLFDW-GTTNCTV------------------------------------GDL VDL----LIRNDFL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------APA RLLLPDIIPEIVQV---LPQ--EKLATQK---------------KLLPPYDKEKTHVKP- -VQNH------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------EHISSSLD-SS---PDRKSLEVSD------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TRFQSFSFYELKSVTNN FD-----------------ERPMSAGGNKMGEGGFGVVYKGCI------NSR--TVAVKK LTRM--TDMC---TE--ELKQQFDQ---EIKILAK--CQHENLVQLLGFSSDS-NDFCLV YVYMPNGSLLDRL-SCLD-----GTEPLSWQTRCKIAQGTA--NGIYYLH---AN---NH VHRDIKSANILLDE--------DFLPKISDFGLARTSAK--------FNQ---TV----- --------MTS-RIVGTTAYMAPEAL-R-GE--ITPKSDIYSFGVVLLEIIT-GLPAVDE QR----EPQ--LLLDIKEE------IEDE----------------------------EKH IEDYIDAK---------------MNDVD----STSVEN-MYSIAT--LCLHEKKNKRPDT E---------------------------------------------M-VKHHLQKMTSS- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >M_mulatta_ENSMMUP00000000286 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MNKPITPSTYVRCLNVGLIRKLSDFIDP---QEGWK KL---------------------------AVAIKKPSGDD--RYNQFHIRRFEALLQT-- -GKSPTSELLFDW-GTTNCTV------------------------------------GDL VDL----LIQNEFF---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------APA SLLLPDAVPKT-NT---LPSK-EAVTVQQ---------------KQMPFYDKDRTLMTP- -LQNL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------EQSYMPLDSSS---PENKSLEVSD------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TRFHSFSFYELKNVTNN FD-----------------ERPISVGGNKMGEGGFGVVYKGYV------NNA--TVAVKK LAAM--VDIT---TE--ELKQQFDQ---EIKVMAK--CQHENLVELLGFSSDG-DDLCLV YVYMPNGSLLDRL-SCLD-----GTPPLSWHMRCKIAQGAA--NGINFLH---EN---HH IHRDIKSANILLDE--------AFTAKISDFGLARASEK--------FAQ---TV----- --------MTS-RIVGTTAYMAPEAL-R-GE--ITPKSDIYSFGVVLLEIIT-GLPAVDE HR----EPQ--LLLDIKEE------IEDE----------------------------EKT IEDYIDKK---------------MNDAD----STSVEA-MYSVAS--QCLHEKKNKRPDI K---------------------------------------------K-VQQLLQEMTDS- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_guttata_ENSTGUP00000010778 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PALYIHSMPAWVLEDFCQKMDC-LSDYDWM RF---------------------------ASYV---------ITDQTELRKIKCMEKT-- -GISITRELMWWW-GVRLATV------------------------------------QQL LDL----LQGLQLY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAA QVILDWTS----ASSVTSPEK--EE--------SEPPKQ-I---ISVPPTEGKVRDKENA ISLLPFPDSSHLGAV---------------------------PAGSAVSAGALYSL---- ----------------------------------------PAPPP--------------- ------------------------------------------------------------ -----------------------------PPRDLLNSL-----QSN--PPVLS------- -------SVK--PCS--------------------------------S-------STPQ- ----Q------------------------------------------------------- ------------------------------------------------------------ ------------------------------------ETMADLLSGSLLWTQREIANATNS FS-----------------D------KNRICEGTFADIYKGQR------NNM--VFVIKR LKEAMLECTS---PD--STQRFFHT---EVQICFR--CCHINILQLLGFSVET-GSHCLI YPYLPNGSLQNKL-QCHD-----DSAPLTWEMRISISLGVV--RAVEYLH---NF---GI LHGNIKSSNVLLDE--------NFTPKLGHSGL-RLHSS-----DKKSEY--AMM----- --------KTK-VLQASLTYLPEDFV-RHGQ--LTEKVDIFSCGVVLAEILT-GIKALDE DR----HPI--YLKDMIAD------EIQS-AKEGSNSKVKNL----------EKLAAKEI CCKYLDRK---------------AGHLL----EEVAVD-FASAIC--LCLR---KKNLNI A---------------------------------------------E-VREIMEMAENKL K-------------------------EHYI-----C-GSSTSGFSMNTPEETDDETASVS VDVPSAVG----------------------S------KEESSQAAILTSGSPCAP----S TGAVAPDTYGIYMSRVPCESDESS----------------SFMWNP-------------- ----------------------PE-----------------------------KS-TEEL ASHKCSNSEKAAGCDYGI---KQGKPAQRLQERSLVCTRGDGILEAAAAAQGTSPQGSTD LDSSSAPQGKGA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >B_taurus_ENSBTAP00000008135 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MSCYIYQLPSWVLDDLCRNMDT-LSEWDWM QF---------------------------ASYV---------ITDLTQLRKIKSMERAQ- -GVSITRELLWWW-GMRQATV------------------------------------QQL LDL----LCHLELY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAA QIILNWKP----VLEVKSSIPDFSD-------TVKPGKPLA---ASVRNTEDK-QETGQP VR---------PPTF---------------------------PGSGPAAVRV-------- -----------------------------------------NLPA--------------- ------------------------------------------------------------ -----------------------------PPEDASSSL-----KTN--QTASA------- -------DSK--DFS--------------------------------A-------SIPK- ----Q------------------------------------------------------- ------------------------------------------------------------ ------------------------------------ETLSSLAGDDLFWSEVDVIQATDN FN-----------------P------SHKISEGTFADVYRGHK------RGT--PFIFKK LREM--ACSG---PG--SVEKFFQA---EVQICRR--CCHPNVLPLLGCCTGE-QFYSLI YPYMANGSLQDRL-QGQG-----GSDPLPWPQRISICSGLL--HAVEHLH---SL---EI IHGNVKSSNVLLDQ--------NFTPKLAHSMA-HPCPV-----NRTSKY--TMM----- --------KTH-LFQASTAYLPEDFI-RVGQ--LTKRVDIFSCGIVLAEVLT-GIPAMDN NR----NPV--YLKDLLLH------EIPS-STISLCSRKMGV----------EKEMAKEI CQKYLEKR---------------AGRLP----EAHAEA-LVMAAC--LCLR---RRNASL A---------------------------------------------E-VCSSVAAVEEQL R-------------------------GQETS-LPCSGLSEGTGSSFNTPEETDD-VDNSS FDGSYS-----------------------------------MRAAPWAGATSSPP----L TA----DEEGMLLAGGAVEADSSA----------------EACAPP-------------- --------------------EPPQ-----------------------------DA-TETS WKIEINEAKRKLMENILL---YKEEKLD-------------------------------- -----SIELFGP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >C_familiaris_ENSCAFP00000007680 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MSCYIYQLPAWVLDDLCRNMDT-LSEWDWM QF---------------------------ASYV---------ITDLTQLRKIKSMERVQ- -GVSITRELLWWW-GMRQATV------------------------------------QQL VDL----LRRLQLY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAA QIILNWKP----VPEINCSFLDFPE-------AVKPGRPLE---ASVRTMEDE-QEKGPS VR---------PADF---------------------------PGPGILMAKNQRAS---- ----------------------------------------TVMKA--------------- ------------------------------------------------------------ -----------------------------CATDAPHSL-----KTD--VPVSS------- -------NSK--DFS--------------------------------T-------SIPK- ----Q------------------------------------------------------- ------------------------------------------------------------ ------------------------------------ETLLSLAGDSLFWSETDVVQATDN FN-----------------Q------NYKISEGNFADIYKGQK------HGT--LFVFKK LREA--AYSG---PG--SIEKFFQA---EVQICHR--CCHPNILPLLGFCTGN-QLYILI YPYMANGSLQDRL-QDQD-----GSEPLLWPQRASICSGLL--RAVEHLH---GL---GI IHGNVKSSNVLLDQ--------NFIPKLAHPIA-HLCSD-----NKRSKY--TMM----- --------KTH-LFQASAAYLPEDFI-RVGQ--LTKRVDIFSCGIVLAEVLT-GIPAMDN NR----SPV--YLKDLLLG------EIPS-STTSLGCRKTGV----------EKVMAKEI CRKYLEKR---------------AGRLL----EDCAET-LALAAC--LCLR---RRNACL A---------------------------------------------E-VCGSVAAVEERL R-------------------------GQETL-LPSSGLSEGTSSSSNTPEETDD-VDNSS LDASYS-----------------------------------MRVAPGAGAAASFL----P TE----DGEGRLQVCGGMQADSSS----------------VACAGP-------------- --------------------EPPQ-----------------------------DATTETS WKIEINEAKRKLMENILY---YKEGKLD-------------------------------- -----SIELLGP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >G_gallus_ENSGALP00000035437 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------ASYV---------ITDQTELRKIKCMEKT-- -GISITRELMWWW-GVRLATV------------------------------------RQL LDL----LQALQLY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAA QVILDWIS----PSSISTSEK--EE-------LVEPPKQEN---VSLTPTENKHKEKENE ISLLPSSDLSQPGIS---------------------------PACNAVSEGTLYSL---- ----------------------------------------PSPPP--------------- ------------------------------------------------------------ -----------------------------PPRDLLKSL-----QSN--PSVSS------- -------SVK--PCS--------------------------------S-------STPQ- ----Q------------------------------------------------------- ------------------------------------------------------------ ------------------------------------ETMTDLPSGSLLWTQKEVTNATDG FS-----------------G------KNRICEGTFADVYKGQR------HNM--VYVIKR LKEAITECTS---PN--STQRFFHT---EVQICFR--CCHVNILQLLGFTVES-ELHCLI YPYLPNGSLQNKL-QHQD-----DSAPLPWEIRLSISVGLI--RAVEYLH---NF---GI LHGNIKSSNVLLDE--------NFTPKLGHSGL-RLYSA-----DKKSEC--TMM----- --------KTK-VMQASLTYLPEDFV-RHGQ--LTEKVDVFGCGVVLAEILT-GIKALDE GR----SPI--YLKDMIAD------EIQT-AKETSHSKDKNL----------EKLAAKEI CCKYLDKK---------------AGHLL----EEVAID-FASATC--LCLK---KKNSNI T---------------------------------------------E-VLEIMETAENKL R-------------------------EHYI-----CGGGSTSGFSMNTPEETDDETTNLS VDAPSAGQ----------------------N------KDDSTQPVLLASGGQCTP----S VGVVPPDTYCEQMSRVPCESDEST----------------SFIWNP-------------- ----------------------EE-----------------------------KS-TDEL FSNNYNNSENITSSDCRM---KERTKANGLRERNVVCIRSDDNLEMAATAHSTFQPKNAD LDSASSSQGKCR------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >B_taurus_ENSBTAP00000028115 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MNKPITASTYVRCLSLGLIRKLSDFIDP---QEGWK KL---------------------------AVAIKKPSGDD--RYNQFHIRRFEALLQI-- -GKSPTCELLFDW-GTTNCTV------------------------------------GDL VDI----LVQNEFF---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------APA SLLLPDAVPKNVNT---LPSKVTVVAVQQ---------------KPKPLCGKDRTSVIS- -DENP------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------EQNYVLPDSSS---PENTSLEFSD------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TRFHSFSFFELKDVTNN FD-----------------ERPISVGGNKMGEGGFGVVYKGYV------NNR--TVAVKK LAAM--VDIS---TE--ELKQQFDQ---EIKVMAK--CQHENLVELLGFSSDG-DDLCLV YVYMPNGSLLDRL-SCLD-----GTPPLSWNMRCKIAQGAA--NGLSYLH---EN---HH IHRDIKSANILLDE--------DFTAKISDFGLARASEK--------FAQ---TV----- --------MTS-RIVGTTAYMAPEAL-R-GE--ITPKSDIYSFGVVLLEIIT-GLPAVDE HR----EPQ--LLLDIKEE------IEDE----------------------------EKT IEDYVDRK---------------MNDID----STSIET-MYSVAS--QCLHEKKNKRPDI K---------------------------------------------K-VQQLLEEMTGS- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >C_familiaris_ENSCAFP00000014260 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MNKPITSSTYVRCLNLGLIRKLSDFIDP---QEGWK KL---------------------------AVAIKKPSGDD--RYNQFHIRRFEALLQT-- -GKSPTCELLFDW-GTTNCTV------------------------------------GDL VDL----LIQNEFF---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------APA SLLLPDAIPKTPNT---VPSE-EAVTVQQ---------------QQMPLNGKDRTFVLP- -VQNF------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------EQNYMPPDSSS---PENTSLEGSD------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TRFHSFSFYELKNVTNN FD-----------------ERPISLGGNKMGEGGFGVVYKGYV------NNK--TVAVKK LAAM--VDIS---TE--ELKQQFDQ---EIKVMAK--CQHENLVELLGFSSDG-DDLCLV YVYMPNGSLLDRL-SCLD-----GTPPLSWHMRCKIAQGAA--NGISFLH---EN---HH IHRDIKSANILLDE--------DFTAKVSDFGLARASEK--------FAQ---TV----- --------MTS-RIVGTTAYMAPEAL-R-GE--ITPKSDIYSFGVVLLEIIT-GLPAVDE HR----EPQ--LLLDIKEE------IEDE----------------------------EKT IEDYIDPK---------------MNDTD----PTSIET-MYSVAS--QCLHEKKNKRPDI E---------------------------------------------KVVQQLLQDLTAS- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >G_aculeatus_ENSGACP00000001480 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MSAGDQRSTFLYKLPPPVLWEFCLVMDG-LSDLDWT RFVE-------------------------ASEV---------LGDQTAVRLAEK------ -RERRTDWVMNQW-CNRNGSV------------------------------------GEL LEL----LERLEML---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RPR DVILRSVP----PLPSHKQSEATPT-------LSTVRVGYT---DGDDIISPKFQSSGLS FE------------------------------------------PYSFILKGFQSS---- ----------------------------------------RSAVV--------------- ------------------------------------------------------------ -----------------------------QVPPMKKEEDP---SPD--RPLPP------- -------------------------------------------------------PFCT- ----L------------------------------------------------------- ------------------------------------------------------------ ------------------------------------TSLKLPSSGVMCWSYEEVHAGTGG FS-----------------P------SLQVGEGGFGVVYRASL------RNT--DCAVKR LKQD--CLLD---WI--QLRESFQN---EVDQLSK--FRHPHIVDLLGFSEGP-ETVCLI YSYMELRSLEDQL-QHKQCVCPQECVSLTWSQRVGVVKGAS--AALQFLHFPPDGHA-AL IHGDVKSSNILLDR--------HLVAKLADFGLARLAHRRPAGRSAGQTA--SVG----- --------KTA-TVRGTLAYLPVEYV-RNGE--LGTAVDVYSFGVVLLEVLT-GRRALEL GR--KSGET--YLKDLVEE------VEENLTGSSAEA----------------------- WRKQLDHRLIP------------GDAAE----PPGCME-LVDLAC--KCLDKKRKKRPAM T---------------------------------------------E-V----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >M_musculus_ENSMUSP00000074471 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MNKPLTPSTYIRNLNVGILRKLSDFIDP---QEGWK KL---------------------------AVAIKKPSGDD--RYNQFHIRRFEALLQT-- -GKSPTCELLFDW-GTTNCTV------------------------------------GDL VDL----LVQIELF---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------APA TLLLPDAVPQTVKS---LPPR-EAATVAQ---------------THGPCQEKDRTSVMP- -MPKL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------EHSCEPPDSSS---PDNRSVESSD------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TRFHSFSFHELKSITNN FD-----------------EQPASAGGNRMGEGGFGVVYKGCV------NNT--IVAVKK LGAM--VEIS---TE--ELKQQFDQ---EIKVMAT--CQHENLVELLGFSSDS-DNLCLV YAYMPNGSLLDRL-SCLD-----GTPPLSWHTRCKVAQGTA--NGIRFLH---EN---HH IHRDIKSANILLDK--------DFTAKISDFGLARASAR--------LAQ---TV----- --------MTS-RIVGTTAYMAPEAL-R-GE--ITPKSDIYSFGVVLLELIT-GLAAVDE NR----EPQ--LLLDIKEE------IEDE----------------------------EKT IEDYTDEK---------------MSDAD----PASVEA-MYSAAS--QCLHEKKNRRPDI A---------------------------------------------K-VQQLLQEMSA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >G_gallus_ENSGALP00000015600 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MSQPVTAATYVRSLRYGLLRQLADLLDP---QEGWK RL---------------------------AAAITDPAGDS--RYSQAHIRRFEAFVQM-- -GKSPTCELLYDW-GTTNCTV------------------------------------GDL VDL----LIRNQFL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------APA SLLLPEAVGMAQEVTLPLSSQ-ETLPVCE---------------KQQPIQEKEVTSVKPV LSQNT------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------EKQPSAPPCLS---QEISSTQSSN------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TDFHNFWFHDLESVTNN FD-----------------ERPESAGGNKLGEGGFGIVFKGYI------NGR--NVAVKK LAAV--VDVS---AQ--DLKQQFDQ---EIEIMAK--CKHENLVELLGFSSDG-AQPCLV YEYMPNGSLLDRL-ACLD-----GTPPISWNTRCEIAQGTA--NGINFLH---DN---NH IHRDIKSANILLTD--------TYVPKISDFGLARASVT--------FTR---TI----- --------MTD-RVVGTAAYMAPEAL-R-GE--ITPKSDIFSFGVVLLEVIT-GLPPVDE NR----EPQ--LLLSIKDE------IEDE----------------------------EAT IEDYVDVK---------------MSDWD----ATSVHK-MYSLAD--QCLNEKKNRRPNM K---------------------------------------------M-VQQYLQEIKT-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >M_mulatta_ENSMMUP00000026192 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MACYIYQLPSWVLDDLCRNMDT-LSEWDWM EF---------------------------ASYV---------ITDLTQLRKIKSMERVQ- -GVSITRELLWWW-GMRQATV------------------------------------QQL VDL----LCHLELY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAA QIILNWKP----VPEIRCPIPAFPD-------CVKPERPLA---ASVRKTEDE-QEEGQP VR---------MATF---------------------------PGPGSSPARAHQQA---- -----------------------------------------FLQP--------------- ------------------------------------------------------------ -----------------------------REEDAPHSL-----RTN--LPTSS------- -------DSK--DYS--------------------------------T-------SIPK- ----Q------------------------------------------------------- ------------------------------------------------------------ ------------------------------------EKLLSLAGDSLFWSEADVVQATDD FN-----------------Q------NHKISQGTFADVYRGHR------HGT--PFVFKK LRET--ACSS---PG--SIERFFQA---ELQICLR--CCHPNVLPVLGFCAAR-QFHSFI YPYMANGSLQDRL-QGQG-----GSDPLPWPQRVSICSGLL--CAVEYLH---GL---EI IHSNVKSSNVLLDQ--------NLTPKLAHPMA-HLCPV-----NKRSKY--TVM----- --------KTH-LFQASVAYLPEDFI-RVGQ--LTKRVDIFSCGIVLAEVLT-GIPAMDN NR----SPV--YLKDLLLS------EIPS-STASLCSRKTGV----------ENVMAKEI CQKYLEKG---------------AGRLP----EDCAKA-LATAAC--LCLR---KRNISL Q---------------------------------------------E-VRGSVAAVEERL R-------------------------GWETL-LPWSGLSEGTGSSSNTPEETDD-VDNSN LDASSS-----------------------------------ASVAPWAGPATSLL----P TE----NGEGRLQVIMGREADSSS----------------EACVGP-------------- --------------------EPPK-----------------------------DA-TETS WQIEINEAKRKLMENILL---YKEEKLD-------------------------------- -----SIELFGP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >P_troglodytes_ENSPTRP00000025212 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MACYIYQLPSWVLDDLCRNMDA-LSEWDWM EF---------------------------ASYV---------ITDLTQLRKIKSMERVQ- -GVSITRELLWWW-GMRQATV------------------------------------QQL VDL----LCRLELY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAA QIILNWKP----APEIRCPVPAFPD-------SVKPEKPLA---ASVRKAEDE-QEEGQP VR---------MATF---------------------------PGPGSSPARAHQLA---- -----------------------------------------FLQP--------------- ------------------------------------------------------------ -----------------------------PEEDAPHSL-----RSD--LPTSS------- -------DSK--DFS--------------------------------T-------SIPK- ----Q------------------------------------------------------- ------------------------------------------------------------ ------------------------------------EKLLSLAGDSLFWSEADVVQATDD FN-----------------Q------NHKISQGTFADVYRGHR------HGK--PFVFKK LRET--ACSS---PG--SIERFFQA---ELQICLR--CCHPNVLPVLGFCAAR-QFHSFI YPYMANGSLQDRL-QGQG-----GSDPLPWPQRVSICSGLL--CAVEYLH---GL---EI IHSNVKSSNVLLDQ--------NLTPKLAHPMA-HLCPV-----NKRSKY--TMM----- --------KTH-LLRTSAAYLPEDFI-RVGQ--LTKRVDIFSCGIVLAEVLT-GIPAMDN NR----SPV--YLKDLLLS------EIPS-STASLCSRKTGV----------ENVMAKEI CQKYLEKG---------------AGRLP----EDCAEA-LATAAC--LCLR---RRNTSL Q---------------------------------------------E-VCGSVAAVEERL R-------------------------GRETL-LPWSGLSEGTGSSSNTPEETDD-VDNSS LDASSS-----------------------------------MSVAPWAGAATPLL----P TE----NGEGRLRVIVGREADSSS----------------EACVGP-------------- --------------------EPPQ-----------------------------D------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >P_pygmaeus_ENSPPYP00000005053 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MNKPITSSTYVRCLNVGLIRKLSDFIDP---QEGWK KL---------------------------AVAIKKPSGDD--RYNQFHIRRFEALLQT-- -GKSPTSELLFDW-GTTNCTV------------------------------------GDL VDL----LIQNEFF---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------APA SLLLPDAVPKTANT---LPSK-EAVTVQQ---------------KQMPFYDKERTLMTP- -VQNL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------EQSYMPPDSSS---PENKSLEVSD------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TRFHSFSFYELKNVTNN FD-----------------ERPISVGGNKMGEGGFGVVYKGYV------NNT--TVAVKK LAA----------------------------------CQHENLVELLGFSSDG-DDLCLV YVYMPNGSLLDRL-SCLD-----GTPPLSWHMRCKIAQDAA--NGINFLH---EN---HH IHRDIKSANILLDE--------AFTAKISDFGLARASEK--------FAQ---TV----- --------MTS-RIVGTTAYMAPEAL-R-GE--ITPKSDIYSFGVVLLEIIT-GLPAVDE HR----EPQ--LLLDIKEE------IEDE----------------------------EKT IEDYIDKK---------------MNDAD----STSVEA-MYSVAS--QCLHEKKNKRPDI K---------------------------------------------K-VQQLLQEMTAS- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >P_pygmaeus_ENSPPYP00000015274 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MACYIYQLPSWVLDDLCRNMDA-LSEWDWM EF---------------------------ASYV---------ITDLTQLRKIKSMERVQ- -GVSITRELLWWW-GMRQATV------------------------------------QQL VDL----LCRLELY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAA QIILNWKP----APEIRCPIPAFPD-------SVKPEKPLA---ASVKKAENE-QEEGQP VR---------MATS---------------------------PGPGSSPARAHQPA---- -----------------------------------------FLQP--------------- ------------------------------------------------------------ -----------------------------PEEDAPHSL-----RTD--LPTSS------- -------DSK--DFS--------------------------------T-------SIPK- ----Q------------------------------------------------------- ------------------------------------------------------------ ------------------------------------EKLLSLAGDSLFWSEADVVQATDD FN-----------------Q------NHKISQGTFADVYRGYR------HGT--PFVFKK LRET--ACSS---PG--SIERFFQA---ELQICLR--CCHPNVLPVLGFCAAR-QFHSFI YPYMANGSLQDRL-QGQG-----GSDPLPWPQRVSICSGLL--CAVEYLH---GL---EI IHSNVKSSNVLLDQ--------NLTPKLAHPMA-HLCPV-----NKRSKY--TMM----- --------KTH-LFRTSAAYLPEDFI-RVGQ--LTKRVDIFSCGIVLAEVLT-GIPAMDN NR----SPV--YLKDLLLS------EIPS-STASPCSRKTGV----------ENVMAKEI CQKYLEKG---------------AGRLP----EDCAEA-LATAAC--LCLR---KRNTSL Q---------------------------------------------E-VRGSVAAVEEWL R-------------------------GREML-LPWSGLSEGTGSSSNTPEETDD-VDNSS LDASSS-----------------------------------VSVAPWAGAATPLL----P TE----NGEGRLRVIVGREADSSS----------------EACVGP-------------- --------------------EPPQ-----------------------------DV-TETS WQIDINEAKRKLMENILL---YKEEKLD-------------------------------- -----SIELFGP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >H_sapiens_ENSP00000256458 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MACYIYQLPSWVLDDLCRNMDA-LSEWDWM EF---------------------------ASYV---------ITDLTQLRKIKSMERVQ- -GVSITRELLWWW-GMRQATV------------------------------------QQL VDL----LCRLELY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAA QIILNWKP----APEIRCPIPAFPD-------SVKPEKPLA---ASVRKAEDE-QEEGQP VR---------MATF---------------------------PGPGSSPARAHQPA---- -----------------------------------------FLQP--------------- ------------------------------------------------------------ -----------------------------PEEDAPHSL-----RSD--LPTSS------- -------DSK--DFS--------------------------------T-------SIPK- ----Q------------------------------------------------------- ------------------------------------------------------------ ------------------------------------EKLLSLAGDSLFWSEADVVQATDD FN-----------------Q------NRKISQGTFADVYRGHR------HGK--PFVFKK LRET--ACSS---PG--SIERFFQA---ELQICLR--CCHPNVLPVLGFCAAR-QFHSFI YPYMANGSLQDRL-QGQG-----GSDPLPWPQRVSICSGLL--CAVEYLH---GL---EI IHSNVKSSNVLLDQ--------NLTPKLAHPMA-HLCPV-----NKRSKY--TMM----- --------KTH-LLRTSAAYLPEDFI-RVGQ--LTKRVDIFSCGIVLAEVLT-GIPAMDN NR----SPV--YLKDLLLS------DIPS-STASLCSRKTGV----------ENVMAKEI CQKYLEKG---------------AGRLP----EDCAEA-LATAAC--LCLR---RRNTSL Q---------------------------------------------E-VCGSVAAVEERL R-------------------------GRETL-LPWSGLSEGTGSSSNTPEETDD-VDNSS LDASSS-----------------------------------MSVAPWAGAATPLL----P TE----NGEGRLRVIVGREADSSS----------------EACVGL-------------- --------------------EPPQ-----------------------------DV-TETS WQIEINEAKRKLMENILL---YKEEKVD-------------------------------- -----SIELFGP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_guttata_ENSTGUP00000006104 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MGEPVTDSTHVRCLSYGLVRRLADFIDP---QEGWK KL---------------------------AVDITNPSGES--RYSQVHIRRFEAFVQM-- -GKSPTCELLYDW-GTTNCTV------------------------------------ADL VDL----LIRNQFL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------APA SLLLPEAVRMPQEVTLPLSSQ-ETLPIHE---------------KQLPVQEKKVASVKPV LAQST------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------EKHNSGSSYSS---EENSSSQSSN------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TDFQNFLFHDLESITNN FD-----------------ARPESAGGNKLGEGGFGIVFKGYI------NGK--NVAVKK LIAM--VDVS---VQ--DLKQQFEQ---EINIMAK--CQHENLVELLGFSSDG-AQPCLV YEYMPNGSLLDRL-ACLD-----ETPPIPWNMRCKIVQGTA--NGINFLH---EN---NH IHRDIKSANILLTD--------TYVPKISDFGLARASVT--------FTQ---TI----- --------MTE-RIVGTAAYMAPEAL-R-GE--ITPKSDIFSFGVVLLEIIT-GLPPVDE NR----EPQ--LLLTIKDE------IEDE----------------------------EAT IEDYVDVK---------------MSDWD----VPSIHK-MYSIAD--RCLNDKKNRRPDI K---------------------------------------------M-VQQQLQEIKT-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >C_elegans_K09B11.1 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------MDDSLGVSEVVMIPFMKREVLQQICAILDT---DNTWE TI---------------------------APYM-----------PGIELRDVEGCKRYSS YNQSPSELLLRIW-SSKGYST------------------------------------THL YQL----FAKTKLI---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RLM RMMRSQVHEKYHYLENKVTNSTSRV-------SKQMVQPPGSQSASRLKKTEIKESSP-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------SPAAAAASQLS---RSNTDDTLRV------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AIEGTLPVTYCELLEATNG FA-----------------V------SNVIGKGGYGTVYKGEL------KGTGGIVAVKR LHSG--NDTS---QN--GSRERLRQSLTELRTLAR--FRHDNILPIYAYSLEG-SEPCLV YQFMSNGSLEDRL-LCRK-----GSVPLTWIQRKEISIGAG--RGLGFLH---SFGKTPI IHGDIKTANILLDK--------HMEPKIGDFGLCRDGHV------EAEAMEKHPL----- --------IAS-HIKGTLAYLAPEFI-TSKI--LTTKLDVYSFGIVLLEIAS-GQRAYSD SR----ETR--GLVEYCQV------NKEL-----------------------AAHRKIPV REIFIDRR---------------APPLVGDEEKSFLDA-LIEVGL--AGANNDRKVRPTM S---------------------------------------------Q-IVEYLCKNSIPP VV---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >E_caballus_ENSECAP00000010808 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MSCYIYQLPSWVVDDLCRNMDT-LSEWDWM HF---------------------------ASYV---------ITDLTQLRKIKSMERVQ- -GVSITREVLWWW-GMRQATV------------------------------------QQL VDL----LCHLELY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAA QIVLNWKP----APEIKSSVPYFPD-------AVNPGRPLA---ASVRDTKDG-QEQGQP TR---------TAAS---------------------------PGSKSSVSRGPWPA---- -----------------------------------------LLPL--------------- ------------------------------------------------------------ -----------------------------PPEDASSAL-----NTE--PPASS------- -------DSK--DFS--------------------------------A-------SIPE- ----E------------------------------------------------------- ------------------------------------------------------------ ------------------------------------ETLLSLAGDSLFWSEADVVQATDN FN-----------------Q------NHKISEGTFADVYRGHR------HGE--PFVFKK LREA--STSCLPVRR--SIKKFFQA---EVQICHR--CCHPNVLPLLGFCTGG-QFHSLV HPYMANGSLQDRL-QHQG-----GSDPLLWLQRVSICSGLL--RAVEHLH---GL---DI IHSNIKSSNVLLDE--------NFTPKLAHPMA-HLCPV-----NKRSRY--TVM----- --------KTH-LFQASAAYLPDDFI-RVGQ--LTKRVDVFSCGIVLAEVLT-GIPAMDN GR----SPV--YLKDLLLS------EIPS-STTSLCSRKTDV----------EKVMAKEL CQKYLEKR---------------AGRLP----EGCAEA-LATAAC--LCLR---RRNASL A---------------------------------------------E-VCGSVAAVEEKL R-------------------------GQDTS-LPWSGLSEGTGSSSNTPEETDD-VDNSS FDGSCS-----------------------------------MRTAPSAGAAALPP----P TE----DGEGRPPAGGEIEADSSS----------------EACASG-------------- --------------------EPPR-----------------------------DA-TETS WKIEINEAKRKLMQNILL---YKEKKLD-------------------------------- -----SIELLGL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_nigroviridis_ENSTNIP00000007783 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PGPGQTNIQLVGLPDWELFLYELPSAVYWDFCRVMDT-LSDLDWT RF---------------------------ASLV---------LDDQTALRLAEK------ -QAHAPDWVMNRW-GSRNGRV------------------------------------RDL LHL----LEGLELL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RPR DLILNGQS----SPPLRTPV------------TSSLRPDSS---PFEGVSCPDWERRWFW SR---------PSML---------------------------AHP--GCCSSSKGN---- ----------------------------------------TWSLL--------------- ------------------------------------------------------------ -----------------------------KVHKLQSEIQP---PAP--PGQPH------- -------TQPSIAEA--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------SCTSGLMCWSYEEVHAGTKE FS-----------------P------TLQVGEGGFGVVYKATL------RNT--VCAVKV LKQD--RLLD---WK--LLKESFRT---EMEKLSK--FRHPNIIDLLGFSEGP-GTVCLI YNYMENKSLEHKL-HNAR----QQGSCLSWSQRVGVVTGAS--TALQFLHCPPKGNA-PL IHGDVKSSNILLDQ--------HMTAKLGDFGLASLALK---SSSPSATT--TLG----- --------CTT-TIRGTLAYLPMEYV-RKGE--LGTVVDVYSFGVVLLEVLT-GRRALEK DK--TSRER--YLKDLVDE------IKESPSGSSQKT----------------------- RHPAVAFPVETKPPGMPSPAVSAGGASE----PAGWME-MVALAC--MCLDKNRKRRPAM A---------------------------------------------E-VGDRLPRLPAPC ------------------------------P-PLRLAVLVKPTRAEAFPSMTSSPNSGLT GQPGDV------------------------------------------------------ --SAPPPETSTAALQLPQTSQTSLLSPLKNSTAFHCSPVAPVTSLG-------------- -------------------QEGFCDQSPGGSPRQERQRRSAASLSRCPLCALSSPWSPGP QVVLMNPIKQHFLQKKTL---YEEGRIR-------------------------------- -----TPELLSSEDIY----EGTSSGAPEESDELDY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >G_aculeatus_ENSGACP00000005326 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MNNSVTSASYIRNLSYSLRRRLSDFLDP---QDRWM EV---------------------------LTSIRKPSGEP--RYSQLHVRRFEGLAAQ-- -GKSPTVELLVDW-GTTNSTV------------------------------------GEL VCI----LKSCKLL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------AAA SLLLPGRPLLSTNISLSFCPHAEQGAVSQETQETQRASPAVDTKSRLPTRLLEETKTRAP PEVSV------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------LPSHI---------PQELSGPSRA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AGFSSFLYNELMEITGN FD-----------------DRPISDGGSRLGEGGFGTVYKGLL------HDR--PVAVKK LNPM--DDIS---LD--ELQVQFNQ---EIQALRV--LKHENLVDMVGFSCDG-QHPCLV YALMVNGSLLDRL-ACLE-----GSPPLSWRQRSLIAEGTA--RGLEYLH---GN---HH VHRDVKSANILLDE--------NLVAKISDFGLTRASAK--------RTS--TTM----- --------MTE-RIVGTRAYMAPEAL-R-GE--ITPRSDVFSFGVVLLEILS-GQRPADE ER----EPQ--FLMEMRHD------IDDE--------------------------DEELT FEDFLDKK---------------MSDWE----PSQVES-VYSLAG--SCLHDRKNRRPVI E---------------------------------------------Q-VDTQILLLNLPN NPVKTR------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >O_latipes_ENSORLP00000003907 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MDSSVTSATYVRNISYSLRRKLSDCLDP---YETWR DL---------------------------IVALRKPNGEP--RYTQHHVRRFEGLVAQ-- -GKSVTVELLNDW-GTTNSTV------------------------------------GEL VDI----LRSLNLL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------AAA NLLLPVFVLHMNN----------KEVLSKETQQVS----SVKAEKCPPTLLLGEAPNPP- -AGSS------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------LQTQTLLDDGG---DDTGGCKVFSKPYFIIF GQ---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------IFLWHFSDGGHVFLYGELMRITRN FD-----------------DRSISDGGSRIGAGGFGTVYKGLL------DSR--LVAVKK LSPM--EDMP---LE--SLQLQFNQ---EIQTLKV--LKHQNLVDMVGFSSDE-QHLCIV YALMANGSLLDRL-ACLD-----GSPPLSWQLRCFISEGAA--RGLEYLH---SN---HH VHRDVKSANILLDE--------NYVAKISDFGLTRASAN--------RTS--TTM----- --------MTE-RIVGTRAYMAPEAL-R-GE--VTPKSDVFSFGVVLLEILS-GLPPADE KQ----EPQ--FLMEFRYD------IDDE--------------------------DEELT LEDFVDKK---------------MSDWT----KGQVES-IYCLAS--NCLHERKNRRPVI K---------------------------------------------Q-VWEYLVGRDRKC HAE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >M_domestica_ENSMODP00000033729 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TTQYIYQLPSWVLEDFCHKMDS-LSEWDWM QF---------------------------ASYV---------MTDQTQLRKIKSMERIQ- -GVSITRELLWWW-GMRQATV------------------------------------QQL LDL----LYRLELY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAA QVILDWGA----IPEIASASHVLPD-------STHPGKSSL---ASLRKPEET-QEKGLQ KS---------SGLT---------------------------PSSSSGPSGCSNRV---- ----------------------------------------LQLPF--------------- ------------------------------------------------------------ -----------------------------IEDDLPHSL-----KTN---PSTS------- -------DIK--NCH--------------------------------A-------YITQ- ----H------------------------------------------------------- ------------------------------------------------------------ ------------------------------------QPLLSLNGESLYWTEMEVIKATNG FG-----------------Q------ENKISQGTFADVYKGQR------HNI--TYVFKK LQKA--STRC---PRNLSVESFFHM---EVQICLR--CSHQNILPLLGFCTGE-VFHSVI HPYMPNGSLEDRL-RCQD-----NTDPLSWEQRISISLGFL--GAIEYLH---GL---KI IHGNIKSSNVLLER--------NFIPKLGHPRV-RVSSN-----DKKSSY--TMM----- --------NTQ-LFQAVAAYVPEDFL-RVGQ--LTERVDIFSCGIVLAEILT-SIPAMDK ER----TPV--FLKDLLIS------EIPS-PKTLLCSKNKCV----------EKLAAKEI CQKYQDAK---------------AGYLP----ENCAVD-FATAVY--LCLQ---KKTPNL T---------------------------------------------Q-VCAIVAELNRQI R-------------------------NPQSL-LSPSGNSELKNSSVNTPEETDD-VDNVS VEGSSS--------------------------------DEPDKNGLWAGAGSSSP----Q PG----YREGRCLTNG-IEADSSV----------------GP--GP-------------- --------------------SHPQ-----------------------------DA-TETS WEVEVNDAKKKLMENILL---YEEEKLN-------------------------------- -----SKELFGS------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >A_carolinensis_ENSACAP00000002933 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MNKPITPSTYVRCLGYGMVKQLADFIDP---QEGWK KL---------------------------AVDIKNPSGDN--RYNQMHLRRFEARQQV-- -GKSPTCELLHDW-GTLNCTV------------------------------------SDL VDL----LVKNQFL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------APA RLLLPGNVDLA-GVVYPVQFS-ESVPQ-----------------ITLGTGLKTRTP---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------RKNDFLLGYVTVFTPPFLFSEVST------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------YHFPLLLSGLQIFLFHELKSFTNN FD-----------------DRTVSAGGNKIGEGGFGVVYKGCT------NGR--TVAVKK LTVL--ADVS---ID--DLKKQFEQ---EITIMAK--CQHENLVELLGFSNDF-DQPCLV SDYMPNGSLLDRL-ACLD-----DTPPIPWKTRCNIAQGAS--NGICFLH---EN---NH IHRDVKSANILLTE--------KFVPKLSDFGLARASVK--------FTH---TI----- --------LTE-RIVGTAAYMAPEAL-R-GE--ITPKSDIFSFGVVLLEIIT-GLPPVDE NR----DPQ--LLLTIKEE------IEDE----------------------------EKT LEDYIDEK---------------MSSWS----MASVEQ-MYSIAC--QCLNEKKNRRPDI K---------------------------------------------M-VKQHLEEMAFE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >D_melanogaster_FBpp0084549 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -MSGVQTAEAEAQAQNQANGNRTRSRSHLDNTMAIRLLPLPVRAQLCAHLDA---LDVWQ QL---------------------------ATAV---------KLYPDQVEQISSQKQR-- -GRSASNEFLNIWGGQYNHTV------------------------------------QTL FAL----FKKLKLH---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NAM RLIKDYVSEDL-HKYIPRSVPTISELRAAPDSSAKVNNGPPFPSSSGVSNSNNNRTST-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------TATEEIPSLES---LGNIHISTVQ------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAAESLLEIDYAELENATDG WS-----------------P------DNRLGQGGFGDVYRGKW------KQL--DVAIKV MNYR--SPNI---DQKMVELQQSYN---ELKYLNS--IRHDNILALYGYSIKG-GKPCLV YQLMKGGSLEARL-RAHKAQ--NPLPALTWQQRFSISLGTA--RGIYFLH---TARGTPL IHGDIKPANILLDQ--------CLQPKIGDFGLVREGPK--------SLD--AVV----- --------EVN-KVFGTKIYLPPEFR-NFRQ--LSTGVDVYSFGIVLLEVFT-GRQVTDR VP-ENETKK--NLLDYVKQ------QWRQ--------------------------NRMEL LEKHLA------------------APMG----KELDMC-MCAIEAGLHCTALDPQDRPSM N---------------------------------------------A-VLKRFEPFVTD- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >M_musculus_ENSMUSP00000055073 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MACYIYQLPSWVLDDLCRNIDT-LSEWDWM QF---------------------------ASYV---------ITDLTQLRKIKSMERVQ- -GVSITRELLWWW-SMRQATV------------------------------------QQL VDL----LCHLELY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAA QIVLSWKP----VPESTSPLPAFPE-------AVKPG-AVA---TSRRNLKDE-QEKVRP VK---------PRSL---------------------------LDTGPIMAGAQRQ----- -------------------------------------------RP--------------- ------------------------------------------------------------ -----------------------------CEMDAPCSL-----KTD--APDSP------- -------QSKYCSTS--------------------------------T-------SAPK- ----Q------------------------------------------------------- ------------------------------------------------------------ ------------------------------------ERLLGLPGDRLFWSEADVVQATED FD-----------------Q------SHRISEGTFADIYQGQR------NGV--AFAFKK LREV--AGSS---PG--SMDRFLQA---EMQLCLR--CCHANVLPLLGFCTGR-QFHSLI YPYMANGSLHDRL-WAQG-----NSDMLPWPQRASICSGLL--LAVEHLH---SL---DI IHSNVKSANVLLDQ--------HLNPKLAHPVA-HPHPD-----NKKTKY--TVM----- --------RTH-LFQASAAYLPEHFI-RVGQ--LTKQVDIFSCGIVLAEVLT-GIPAMDK DR----SPV--YLKDLLLS------EIPN-STSSVCSRKTSM----------GKAVVKEI CQRHVEKR---------------AGLLP----EACEEA-WATAVS--VCLR---RRNASV E---------------------------------------------E-ARVSLAGVEEQL R-------------------------GQLS--LPWSRVSEATGSSSNTPEETDD-VDNSS LSVPSL-----------------------------------VMMASCPGAASSPL----F TG----HGAAQPSTSGRQEADSSS----------------EACTGP-------------- --------------------QTPQ-----------------------------NA-TETS WKIEINEAKRRLMENIVL---YKEERLD-------------------------------- -----SSELFGP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_nigroviridis_ENSTNIP00000019071 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MSNSVTSATYIRNLSYSLRRQLSDILDP---QERWK EI---------------------------IVSIRKPNGDF--RYSQHHVRRFAGLPAQ-- -GKSPTEELLADW-GTTNCTV------------------------------------GEL VDM----LKNNSLL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------AAV TLLLPGLKDAIPA------------------ETLQPGPPSGETYSALPTRLLDDAGALA- -GSSS------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------ASTHILPDSRE---PEPSGEPFRN------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------FRLRSVPYNDLIRITND FD-----------------DRPVSDGGCRLGEGGFGAVYKGVL------NQI--PVAVKK LVPI--EDIS---LE--ELRVQFHQ---EVQTLRV--LKHENLVDMVGFSCDG-QYPCVI YPLMSNGSLLNCL-ACLE-----GSPPLSWKQRCSIAEGTA--NGLDYLH---SN---HH VHRDVKSANILLDE--------KRVAKISDFGLTRASPK--------GTS--TTM----- --------MTE-RIVGTCAYMAPEAL-R-GQ--VTPKSDIFSFGVVLLEILS-GLPPADE NR----EPQ--FLMEVTFT------IDDE--------------------------DEELT LEGFLDKK---------------MEDVD----FSQAES-VYTLAC--SCLQDRKNQRPLS K---------------------------------------------Q-VGRGRTHSLTWS ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_rubripes_ENSTRUP00000042842 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MSNSVTSATYIRNLSYSIRRQLSGILDP---QERWK EI---------------------------IISIRKPNGDF--RYSQHNVRRFAGLVAQ-- -GKSPTEELLADW-GTSNCTV------------------------------------GEL VDI----LKSHKLL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------AAA AIVLPGMIQITTA--------------------MQIAFNCTETYSALPTRLLDNKGTQT- -VPSS------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------APTQIQLDSCD---PEPTSEPSQRNTCFHVS QWRE-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------CSQTYPPLGFSSISYNDLIKITDG FN-----------------DRPVSEGGCRLGEGGFGAVYKGVL------NHK--LVAVKK LIPV--EDMS---LE--DLQIQFHQ---EIQTLTV--LQHENLVDMVGFSCDG-QYPCVI YPLMPNGSLLDRL-ACLE-----GTPPLSWKQRCLIAEGTA--SGLEFVH---RN---HH VHRDVKSANILLDE--------KLVAKISDFGLTRASPK--------GTS--TTM----- --------KTE-RIVGTCAYMAPEAL-R-GQ--VTPKSDIFSFGVVLLEILS-GLPPVDE NH----NPQ--FLMEVPSA------IEDE--------------------------DEELT FEGFLDTK---------------MEDVQ----LGQAES-VYTLAC--SCLQDRKNQRPVS K---------------------------------------------Q-SVTRLQYVHLQH LHR--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >C_intestinalis_ENSCINP00000015329 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MSWGWGSFQTPRKQVTAQTYIRNLPYSVLKSIADDLDTAGTATNWR DF---------------------------VLKIPRGPNDPEPRYQLQDIRKFEMIAGR-- -GDSPTTAAIDAW-STSNATV------------------------------------QDL INV----LTSLGLI---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SMV NMLKSQVTMPPPYEEAVNREQTQSTLPYPQQAQYRPVPTPVGQPYQPYPNHNIHQPVYNY ESHRSSHPPIPPRPSIFSDFASIRQPTRPNEQKSY------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------QVSSSEKSLTRQPTENDSALSVGNKLEEEQK SELAFLLQGLNLNAN------------------------------GYYVPTVPILQQRTI SKNFN------------------------------------------------------- ------------------------------------------------------------ ------------------------------------KTDIYSFCSVSPYSYSSLKMLTSD FN-----------------D------SLKLGEGAFGSVFQGHLTQPKDGDSLERKIAIKR LKLD--TPEF---AT--AITEQFKK---EVHVISE--LQHENILPLMGYSCDG-PELCLV YDYMFNGSLSSSL-ESCR----LGKVVLLVGQRLEIAKGSS--NGISYLH---EQ---KL IHRDIKSSNILLDS--------NMKPRISDFGLIRSTST--------KTVDLTST----- --------KTT-NPIGTMVYMSPEAF-K-GV--VSYSMDVYSFGVVLLELLT-GLPVLDE NR----DPS--HLPMFIEE------SMEE---------------------------DETS LSMFADTR---------------AGPWS----NGVDDS-IYELSS--QCLDFRYKRRPTM H---------------------------------------------K-VLSELSAMLCKT EDPQR------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >A_gambiae_AGAP002966-PA ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------CMLC PIMSKPNGQHTEMEGKPSGLSAATTVAPLSNFVYIYDIPRMEKKRLAALLEV---NNKWY EL-----------------------------------GEKQMGYSTVELDSTQRCCQRN- -NRSPAEQLLDKW-GNYNHTI------------------------------------TEL FVV----LSREKLY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NCM ELIKRYVDSRYHVLIKESASDGRNAVANMATFSGANNNANVPNGHRAAHRLKDGAADQKV NGGGGDG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------AAAAAAAATND---KSNPTNSKEN------- --------------------------------------------------------SPF- ----A------------------------------------------------------- ------------------------------------------------------------ ------------------------------------NELADLTSLIPKISYEELTAATDN WS-----------------E------RNILGKGGFGTVYRGNF------KHT--FMAIKK IDYN--KVKS---SE--AERIQLQQSFNELRFLNS--CRHDNIVPLFGYCIE--KEPCLV YQFMPGGSLDKSL-FARR-----PASPLTWRERMNIAIGTA--RGLQYLH---TFGDKPF IHGDIKPGNILLNE--------YKQPRIGDFGLTRQGAV------QDSAT---------- --------VVS-RVYGTRPYIPKEFY-DRRE--LSTKVDTYSFGVVLYEIGT-GLRAWDE RR----TEK--HLKDYIAR------AVQE----------------------------QMH VTQLADQS----------------LPMD-AEALMCCFK-LLQVGR--VCTADDPKQRPDM V---------------------------------------------G-VMWQLSAA---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >X_tropicalis_ENSXETP00000003054 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MWSW-GQKLPTL------------------------------------QKL VER----LQKLEMY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAL GILQQWSPLSVIASKVPERRKAEKESDLKTDNKLPELTYTSPLELPTPPLPAPPP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------PPSDLLHSLSI---QSECSLTCHS------- --------------------------------------------------PEEVLSIPQ- ----Q------------------------------------------------------- ------------------------------------------------------------ ------------------------------------EKSSFSKGLCKIWTQKDVEDATDC FC-----------------S------SKIIHEGEFADVYMGHK------QDK--LYAIKR LKKV--QDEE---QK--RMSSFFHT---EAQISFR--CCHANILPLLGFCVEG-DCSCLI NQFIRNGSLDLAL-QQSG------NHILNWERRLKIALGFL--KAIRHLH---SN---DI LHGNIKSSNIFLDE--------NSFPKLGHSGL-RFCPD------KQAGY--TKA----- --------KSK-DLQVHQPYLPDSFF-RHGQ--LTVQTDIFSCGVVLAEILT-GQKACDK SR----NPV--YLKDLFLE------ELER-AKEYLDSDGKQA-----DHESPESLCSHQI SRKYIDSR---------------AGFLS----NNAAFQ-LSLAAC--LCLT---KKRPLL Q---------------------------------------------E-IYTWVEKADQCS R--------------------------------------DSQNLSLNVPEESDFDDSLSL EPMEGAIS-----------------------------------KMPCTSTQGSWSMDDHN QRNHYPKTENRDVDRTPCESDDSTLYVLPTQRSRHLVGAASAICDH-------------- ---------------------QPTQSDALEQTEAVHGNVQFSWQKSREYSDQSADSSSPS WGIIVNKEKEKLLQNFDLYRDNKLDSGSLFDSI--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >D_rerio_ENSDARP00000093598 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S FV--------------QI-KFDDIHFYENCGGGSFGSVYRARWL----SQDR--EVAVKK LLK-------------------IEK---EAEILSV--LSHRNIIKFYGAILEA-PNYGIV TEYASGGSLFDYL-SSDD------SEDISMQQIMTWAMDIA--KGMHYLH---SEAPVKV IHRDLKSRNGLLSI----------VQNICDFGASKFHSH--------TTH---------- ---------MS-L-VGTFPWMAPEVI-QSLP--VSETCDTFSYGVVLWEMLT-QEIPFKG LE----GLQ--VAWLVVEK------H-ER------------------------------- ------------------------LTIP----SSCPAS-FACLMR--SCWATEPKERPLF K---------------------------------------------H-ILSTLESMWSDT Q-LPDKCNTFLQNKAEWRCEIEATLERLKRL-ERDLSTKEQALKERERRLKMWERKLIEQ SNTPV-------------------------SHYVILATKGRQNHFWMEQIFEG----TGD GELQQYANVFRQN-----HITGQRLLLLSES----DMRDLGVTSKGHIIHLKTEIEKLTH DYLNLFHFPPLIKASE-EADEDWSKTVNLELVFG-YHWKAGTGQKDCKWKMYMELDGDEV AIAYIKDVTFNANRPDVDVLKMTKPPFVMDKWIVGISGTHTVDYIVNYEGNVKSPKCTRH VHTVQWSADSGKDVIKPVELVIETAPGIREAHNRSRSNSGTAENYLQIIKTIIPGRNSQM KEQ-AAQESPSKM---------SLPQFLSVISNQS-SYAAAVRRS---PNRSPLSP-WTD SRSSSPT---LSVKLSNMHL-GSKGSSPSSTTSESASE--RERPPSAGAKHNYNKKP-YY DHHTLKMSSRGDGEPR---RFLPQRGSRGFQHAGRPRNAHSYATPP----HYQRPIPGMS MA----AEGPKQKVASEEPGDGDWIKVERKKTNKQECKYQEVRPVRGRSRRGGRG----- --------------------------------------------------- >A_aegypti_AAEL012999-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MLIV----------------- ------------------------------SGRGRQKQNNPQEPSAVGMSPL--WTARYD YQAQGEDELSLRV--------------------------------------------GQI VFV----LSMDSSI---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SGD EGWWTGK-IGDRVGIFPSNFVTNE------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------DPT VLNVQP---------LEI-KFQELDLREVIGVGGFSKVHRAFW------NGL--EVAVKA SRQ----DED---ID--GTRENVLK---EAKLFWS--LKHPNIVELKGVCLEQ-PILCLV MEYARGGSLNKIL-AGRK---------IPPDVLVDWAIQIA--RGMKYLH---CEAPISV IHRDLKSSNVLICDPVMSGNLKNKTLKITDFGLAREAYT--------TTR---------- ---------MS-A-AGTFAWMPPEVI-KSGT--YSKASDVWSYGVLLWELLT-GETPYKG FD----TLS--VAYGVAIN------S-LA------------------------------- ------------------------LPIP----KTCPEA-WGKLMK--SCWELDPHRRPSF R---------------------------------------------D-IEKDLDTIARSG F-GQTPHESFHTMQDGWKREIAEVLQELRRK-EKELRSKEEELSRVQQEQQFREEDLAKR KQELDAREIELLGRELKIIITQ---NTPTPKKRKGKFSKSKLRLLKRE-PGHISFPLDFR HTITVQPTAIRDECR---QRTDTPPGSPAAT-RLRAIARK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >G_gallus_ENSGALP00000018501 ----AMAAEGGRSAARREATGRRLERFAALRGGAAGAGRD------GGVRAEQERAFRRQ LAAKLRGGELPLGVRYHVFVDPPGPKIGNGGSTLHVLQCLENLYGDKWTSFIVLLIH--- --SDEWKKKVSESYAVIMERLEDDLQIKDKELAELKHVFSSDEAFCKV-----------N LNYRTDNGLSLLHLCCICEGNKSHIRTLMLKGLRP--------SRLTRNGFTALHLAAYK DN---------------------------TELITALLHGG-ADVQQVGYGALTALHIATI AGHRQAVDILLQHGAYVNVQDAVFFTPLHIAAYYGHEQVTHLLLKFGADVNASGEVGDRP LHL----ASAKGFL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NIT KLLMEEGSKAD-GAMAVNAQDNEDHVPLHFCCRFGHHEIVKFLLQSSFEVQPHVV--NIY GDTPLHLACYSGKFDVVKEMIQLSGTESLTKENIFSETAFHSACT-YGKNIELVKF---- ----------------------------------------LLDQNVVSINHQGRDGHTGL HCACYHGHIRLVQFLLDNGADMNLVA----------------CDPSRSSGE--------- -------------KDEQTCLMWAYEKGHDAIVTLLKHY-K---RPQDESPCNEYSQPGG- -DGSYVS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------VPSPLGKIKSMTKE KA-DVLLLRAGLPSHFHL-QLSEIEFHEIIGSGSFGKVYKGRC------RNK--IVAIKR YRA---NTYC---SK--SDVDMFCR---EVSILCR--LNHPCVIQFVGACLDDPSQFAIV TQYISGGSLFSLL-HEQK-------RTLDLQSKLIIAVDVA--KGMEYLH----NLTQPI IHRDLNSHNILLYE--------DGHAVVADFGESRFLQS--------LDE----D----- --------NMT-KQPGNLRWMAPEVFTQCTR--YTIKADVFSYALCLWELLT-GEIPFAH LK----PAA--AAADMAYH------H-IR------------------------------- ------------------------PPIG----YSIPKP-ICALLM--RGWNACPEGRPEF S---------------------------------------------E-VVTKLEECLCNI E-LMSPASSNSSGSLSPSSSSDCLVARGGPG-RSHVAALRSRFE-LEYALNARAYAVWSQ ST-GQHPS---------------------------------------------------- -QGLSLDDMRRNFQYPPIDKNGELLQNAPPSISVWLTSTELQFSDSL------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_nigroviridis_ENSTNIP00000018336 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------PGMKIYIDPFTYEDPNEAVRE FA-------------KEI-DVSTVKIEEVIGAGEFGEVYKGRLKLPGK-REI--YVAIKT LKSGY--------VE--KQRRDFLS---EASIMGQ--FDHPNIIRLEGVVTKS-RPVMIV TEFMENGALDSFL-RQND-------GQFTVIQLVGMMRGIS--AGMKYLS---EM---NY VHRDLAARNILVNS--------NLVCKVSDFGLSRYLQE----DTSDPSY---------- --------TSSLGGKIPVRWTAPEAI-AYRK--FTSASDVWSYGIVMWEVMSFGERPYWD MS----NQD--VINAIEQD--------YR------------------------------- ------------------------LPPP----MDCPST-LHQLML--DCWQKDRNVRPRF A---------------------------------------------D-IVSTLDKMIRNP T--------SLKAIANIPSVPSQPLLDRSIP-DFNTFSSVEDWLGAIKMSQYRDNFLNSG FTSLQLVA---------------------------------------------------- --QMTSE----DLLRIGVTLAGHQKKILSNVQSMRVQMSQ-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >X_tropicalis_ENSXETP00000016378 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MLSLTAS FV--------------QI-KFDDLQFFENCGGGSFGSVYRAKWL----SQDK--EVAVKK LLK-------------------IEK---EAEILSM--LSHRNVIQFYGAVLEP-PNYCIV TEYAACGSLYDYI-NSTR------SENMDMDHIMAWSMDVA--KGMHYLH---MEAPIRV IHRDLKSRNVVITM--------DGILKICDFGASRFHSH--------TTH---------- ---------MS-L-VGTFPWMAPEVI-QSLP--VSETCDTYSYGVVLWEMLT-REVPFKG LE----GLQ--VAWLVVEK------N-ER------------------------------- ------------------------LTIP----SSCPQS-FAELMH--QCWEADSKKRPSF K---------------------------------------------Q-IISNLESMSNDS K-LPDQCNSFLHNKAEWRCEIEETLERLKRL-ERDLSYKEQELKEREKHLKMWEKKLTEQ SHTPLLP-----------------------SFDICAWTE-EDVYVWMQQLVKSD---DE- ---NMYASLFRQH-----HITGKRLLLLEER----DLKDMGIVSKGHIIHLKTAIEKLTH DYLNLFHFPPLIKDFESENDE-EEKLVNLELVFG-YHLKSGSCPEDYKWKMYMELDGDEI AITYIKDVTFNRNQPDVEPLKMTKPPFVMEKWIVGIRENETVECIVTYENDVRTPKITKH IHKIHWDKMKMQDAVKSVQLAIMSPLLTSESKQ-SNYESSVDCQWIYTL------RMRQM ATP-TSPQHAAGLPRSQSSSLSNLSQILPYLQNQE-SYAAAVRRIRASPTL-QVTS-INY SRSSSPTQFGLAKNLSSLSIQSSKGSSASSTASDSPSE--RERAHRTPNNSSYQHSR--H STPMQRRSGG-----RSPQMNSGKNYK--SYTVTYNHSRPFEQRPQ--RTNQNRYIPGMP KL----ESDAAVNGEEKNNNDGGWIKVDYSK--KTHKQTTTSKSHKDRSKSFGRGRR--- --------------------------------------------------- >A_carolinensis_ENSACAP00000011445 -------------------------------GKTVQPGEFWDIIVITAVDRKQEIAYQQQ LSGKLKRKELPLGVHYHVFVDPPGPKIGNGGSTLHVLQCLEEHYDDKWDSLTVLLIH--- --SDEWKKKVSESYTIITERLEDDLLIKEKELTELKHVFSSDEAFGKV-----------N LNYRTETGLSLLHLCCICEGNKSHIRTLMLKGLRP--------SRLTRNGFTALHLAAYK DN---------------------------AELLTALLHSG-ADIQQVGYGALTALHIATI AGHHEAVDILLQHGAYVNVQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRP LHL----ASAKGFL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NIA KLLMEEGSKAD-----VNAQDNEDHVPLHFCSRFGHHDIVKFLLQSNFEVQPHVV--NIY GDTPLHLACYNGKFEVVKELIQLSGTESLTKENIFSETAFHSACT-YGKNMELVQF---- ----------------------------------------LLDQNVLSLNHQGRDGHTGL HSACYHGHIRLVQFLLDNGADMNLVA----------------CDPSRSSGE--------- -------------KDEQTCLMWAYEKGHDAIVTLLKHY-K---RPQDESPCNEYSQPGG- -DGSYVS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------VPSPLGKIKSMTKE KA-DVLLLRAGLPSHFHL-QLSEIEFHEIIGSGSFGKVYKGRC------RNK--IVAIKR YRA---NTYC---SK--SDVDMFCR---EVSILCR--LNHPCVIQFVGACLDDPSQFAIV TQYISGGSLFSLL-HEQK-------RNLDLQSKLIIAVDVA--KGMEYLH----NLTQPI IHRDLNSHNILLYE--------DGHAVVADFGESRFLQS--------LDE----D----- --------NMT-KQPGNLRWMAPEVFTQCTR--YTIKADVFSYALCLWELLT-GEIPFAH LK----PAA--AAADMAYH------H-IR------------------------------- ------------------------PPIG----YSIPKP-ISSLLI--RGWNACPEGRPEF S---------------------------------------------E-MVSKLEECLCNI E-LMSPASSNSSGSLSPSSSSDCLVARGCPG-RSHVAALRSRFE-LEYALNARAYTAWSQ ST-GQQPS---------------------------------------------------- -QGLSLEEMRRNFQYPPIDRNGYVSDPMSTMRFHSCSNSG-SFEDSG------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >B_taurus_ENSBTAP00000001278 MGNYKSRP-----------TQ--------------------------------------- -------------------------------------TC--------------------- --TDEWKKKVSESYVIVIERLEDDLQIKEKELTELRHIFGSDDAFSKV-----------N LNYRTENGLSLLHLCCICGGNKSHIRTLMLKGLRP--------SRLTRNGFTALHLAVYK DS---------------------------AELITSLLHSG-ADIQQVGYGGLTALHIATI AGHLEAADVLLQHGANVNVQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRP LHL----ASAKGFF---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NIA KLLVEEGSKAD-----VNAQDNEDHVPLHFCSRFGHHNIVKYLLQSDLEVQPHVV--NIY GDTPLHLACYNGKFEVAKEIIQISGVESLTKENIFSETAFHSACT-YGKSIDLVKF---- ----------------------------------------LLDQNVISINHQGRDGHTGL HSACYHGHIRLVQFLLDNGADMNLVA----------------CDPSRSSGE--------- -------------KDEQTCLMWAYEKGHDAIVTLLKHY-K---RPQDELPCNEYSQPGG- -DGSYVS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------VPSPLGKIKSMTKE KA-DVLLLRAGLPSHFHL-QLSEIEFHEIIGSGSFGKVYKGRC------RNK--IVAIKR YRA---NTYC---SK--SDVDMFCR---EVSILCR--LNHPCIIQFVGACLNDPSQFAIV TQYISGGSLFSLL-HEQK-------RILDLQSKLIIAVDVA--KGMEYLH----NLTQPI IHRDLNSHNILLYE--------DGHAVVADFGESRFLQS--------LDE----D----- --------NMT-KQPGNLRWMAPEVFTQCTR--YTIKADVFSYALCLWELLT-GEIPFAH LK----PAA--AAADMAYH------H-IR------------------------------- ------------------------PPIG----YSIPKP-IASLLM--RGWNACPEGRPEF S---------------------------------------------E-VVTKLEECLCNI E-LMSPASSNSSGSLSPSSSSDCLVNRGGPG-RSHVAALRSRFE-LEYALNARSYAAWSQ SA-GQCST---------------------------------------------------- -QGLSLDDMKKSLQFSTIDKYGYVSDPMSPMHFHSCRNSG-SFEDSS------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >C_familiaris_ENSCAFP00000030269 LVEARRPPGPGGVSLLREAAQRKLRRFSELRGKPVAPGEFWDIVAITAADEKQELAYKQQ LSEKLKRKELPLGVQYHVFVDPAGAKIGNGGSTLCALRCLEKLYGDKWNSFVILLIHS-- --VDEWKKKVSESYVIIIERLEDDLQIEEKELTELRHIFSSDDAFSKV-----------N LNYRTENGLSLLHLCCICGGNKSHVRTLMLKGLRP--------SRLTRNGFTALHLAVYK DS---------------------------AELITSLLHSG-ADIQQVGYGGLTALHIATI AGHLEAADVLLQHGANVNVQDAVFFTPLHIAAYYGHDTVTRLLLKFGADVNVSGEVGDRP LHL----ASAKGFF---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NIA KLLMEDGSKAD-----VNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDSEVQPHVV--NIY GDTPLHLACYNGKFEVAKEIIQISGIESMTKENIFSETAFHSACT-YGKSIDLVKF---- ----------------------------------------LLDQNVISINHQGRDGHTGL HSACYHGHIRLVQFLLDNGADMNLVA----------------CDPSRSSGE--------- -------------KDEQTCLMWAYEKGHDAIVTLLKHY-K---RPQDELPCNEYSQPGG- -DGSYVS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------LPSPLGKIKSMTKE KA-DVLLLRAGLPSHFHL-QLSEIEFHEIIGSGSFGKVYKGRC------RNK--IVAIKR YRA---NTYC---SK--SDVDMFCR---EVSILCR--LNHPCIIQFVGACLNDPSQFAIV TQYISGGSLFSLL-HEQK-------RILDLQSKLIIAVDVA--KGMEYLH----NLTQPI IHRDLNSHNILLCE--------DGHAVVADFGESRFLQS--------LDE----D----- --------NMT-KQPGNLRWMAPEVFTQCTR--YTIKADVFSYALCLWELLT-GEIPFAH LK----PAA--AAADMAYH------H-LR------------------------------- ------------------------PPIG----YSIPKP-ISSLLM--RGWNACPEGRPEF S---------------------------------------------E-VVTKLEECLCNI E-LMSPASSNSSGSLSPSSSSDCLVSRGGPG-RSHVAALRSRFE-LEYALNERSCATWSQ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >M_mulatta_ENSMMUP00000025611 MGNYKSRP-----------TQ--------------------------------------- -------------------------------------TC--------------------- --TDEWKKKVSESYVITIERLEDDLQIKEKELTELRHIFSSDEAFSKV-----------N LNYRTENGLSLLHLCCICGGNKSHIRTLMLKGLRP--------SRLSRNGFTALHLAVYK DN---------------------------AELITSLLHSG-ADIQQVGYGGLTALHIATI AGHPEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRP LHL----ASAKGFL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NIA KLLMEEGSKAD-----VNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHAV--NIY GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACT-YGKRIDLVKF---- ----------------------------------------LLDQNVININHQGRDGHTGL HSACYHGHIRLVQFLLDNGADMNLVA----------------CDPSRSSGE--------- -------------KDEQTCLMWAYEKGNDAIVTLLKHY-K---RPQDELLCNEYSQPGG- -DGSYVS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------VPSPLGKIKSMTKE KA-DILLLRAGLPSHFHL-QLSEIEFHEIIGSGSFGKVYKGRC------RNK--IVAIKR YRA---NTYC---SK--SDVDMFCR---EVSILCQ--LNHPCVIQFVGACLNDPSQFAIV TQYISGGSLFSLL-HEQK-------RILDLQSKLIIAVDVA--KGMEYLH----NLTQPI IHRDLNSHNILLYE--------DGHAVVADFGESRFLQS--------LDE----D----- --------NMT-KQPGNLRWMAPEVFTQCTR--YTIKADVFSYALCLWEILT-GEIPFAH LK----PAA--AAADMAYH------H-IR------------------------------- ------------------------PPIG----YSIPKP-VSSLLI--RGWNACPEGRPEF S---------------------------------------------E-VVTKLEECLCNI E-LMSPASSNSSGSLSPSSSSDCLVSRGGPG-RSHVAALRSRFE-LEYALNARSYAALSQ SA-GQHSS---------------------------------------------------- -QGLSLEEMKRSLQYSPIDKYGYVSDPMSPMHFHFCRNSS-SFEDSS------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >G_aculeatus_ENSGACP00000015944 T---DSMSQES-VTKLQKATKIKIGKFNSLRAREVQPGEFWDVVAVTAADESQRAAYELQ VRQKVARKELPLGPHYKVFSDPPGPKIGNGGSTLYALQQLNDIYGKSLERLRVILIHHGD GCADEWKKKVGESYAVIVEKLEDDLQLKDDERVELKLAFSSDEAFQKV-----------N LSYRTAKGLSLLHLCCVCGGTKTNMRTLMLKGLRP--------SRLSRNGFTALHLAAYK DD---------------------------AELLTALLHGG-SDVQQVGYGALTALHVATL AGHHEAADILLQHGASVNVQDAVFFTPLHIASYNCNEQLAKLLLKFGADVNASGEVGDQP LHL----AAAKGFL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SII KLLLEEGTKAN-----VNAQDNEDHVPLHFCARFGHHETVRFLLQGNFDVQPHAV--NIY GDTPLHLACYNGKYEAAKAIVQLSGTDSLAKENIFSETALHSACT-YGKDLELVQF---- ----------------------------------------LLSQNATSINNQGRDGHTAL HSACFHGHIRLVQFLLDSGADMNLVA----------------CDPSRSSGE--------- -------------KDEQTCLMWAYEKGHDAIVTLLKHY-K---RP-DDSPCNEYSQPGG- -DGSYVS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------VPSPLGKIKSMTKE KT-EVLLLRASLPSQFHL-QLPDLEFNEIIGSGSFGRVYRGKC------RNK--TVAIKR YRS---NTYC---SK--SDVDMFCR---EVSILCR--LNHPCIIQFVGACLDDPSQFAIV TQYVSGGSLFSLL-HEQK-------RLIDLQSKLIIAIDVA--KGMEYLH----NLTQPI IHRDLNSHNILLYE--------DGHAVVADFGESRFLQS--------VDE----D----- --------NMT-KQPGNLRWMAPEVFTQCTR--YSVKADMFSYALCLWELLT-GEIPFAH LK----PAA--AAADMAYH------H-IR------------------------------- ------------------------PPVG----YSIPKP-ISALLM--RGWNACPEDRPEF S---------------------------------------------E-VLSNLEECLCNV E-LMSPASSNSSGSLSPSSSSDCLLGRGGPG-RSQVAALRSRFE-LEYALNSRAYAFWSQ SE-RRRAS---------------------------------------------------- -GGLSLEEHRRNMQFSPIDRNGYVSDPMSTMRFCSSYSSSGSFEDSN------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >P_troglodytes_ENSPTRP00000001494 MAAARDPP----EVSLREATQRKLRRFSELRGKLVARGEFWDIVAITAADEKQELAYNQQ LSEKLKRKELPLGVQYHVFVDPAGAKIGNGGSTLCALQCLEKLYGDKWNSFTILLIH--- --SDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKV-----------N LNYRTENGLSLLHLCCIFGGKKSHIRTLMLKGLRP--------SRLTRNGFTALHLAVYK DN---------------------------AELITSLLHSG-ADIQQVGYGGLTALHIATI AGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRP LHL----ASAKGFL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NIA KLLMEEGSKAD-----VNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVV--NIY GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACT-YGKSVDLVKF---- ----------------------------------------LLDQNVININHQGRDGHTGL HSACYHGHIRLVQFLLDNGADMNLVA----------------CDPSRSSGE--------- -------------KDEQTCLMWAYEKGHDAIVTLLKHY-K---RPQDELPCNEYSQPGG- -DGSYVS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------VPSPLGKIKSMTKE KA-DILLLRAGLPSHFHL-QLSEIEFHEIIGSGSFGKVYKGRC------RNK--IVAIKR YRA---NTYC---SK--SDVDMFCR---EVSILCQ--LNHPCVIQFVGACLNDPSQFAIV TQYISGGSLFSLL-HEQK-------RILDLQSKLIIAVDVA--KGMEYLH----NLTQPI IHRDLNSHNILLYE--------DGHAVVADFGESRFLQS--------LDE----D----- --------NMT-KQPGNLRWMAPEVFTQCTR--YTIKADVFSYALCLWEILT-GEIPFAH LK----PAA--AAADMAYH------H-IR------------------------------- ------------------------PPIG----YSIPKP-ISSLLI--RGWNACPEGRPEF S---------------------------------------------E-VVTKLEECLCNI E-LMSPASSNSSGSLSPSSSSDCLVNRGGPG-RSHVAALRSRFE-LEYALNARSYAALSQ SA-GQYSS---------------------------------------------------- -QGLSLEEMKRSLQYTPIDKYGYVSDPMSPMHFHSCRNSS-SFEDSS------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >G_gorilla_ENSGGOP00000001846 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MACYIYQLPSXXXXXXXXXXXX-XXXXXXX XX---------------------------XSYV---------ITDLTQLRKIKSMERVQ- -GVSITRELLWWW-GMRQATV------------------------------------QQL VDL----LCRLELY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAA QIILNWKP----APEIRCPIPAFPD-------SVKPEKPLA---ASVRKAEDE-QEEGQP VR---------MATF---------------------------PGPGSSPAGAHQPA---- -----------------------------------------FLQP--------------- ------------------------------------------------------------ -----------------------------PEEDAPHSL-----RSD--LPTSS------- -------DSK--DFS--------------------------------T-------SIPK- ----Q------------------------------------------------------- ------------------------------------------------------------ ------------------------------------EKLLSLAGDSLFWSEADVVQATDD FN-----------------Q------NHKISQGTFADVYRGHR------HGK--PFVFKK LRET--ACSS---PG--SIERFFQA---ELQICLR--CCHPNVLPVLGFCAAR-QFHSFI YPYMANGSLQDRL-QGQG-----GSDPLPWPQRVSICSGLL--CAVEYLH---GL---EI IHSNVKXXXXXXXX--------XXXXXXXXXXX-XXXXX-----XXXXXX--XXX----- --------XXX-XXXXXXXXXXXXXX-XXXX--XXXXXXXXXXXXXXXXXXX-XXXXXXX XX----XXX--XXKDLLLS------EIPS-STASLCSRKTGV----------ENVMAKEI CQKYLEKG---------------AGRLP----EDCAEA-LATAAC--LCLR---RRNTSL Q---------------------------------------------E-VCGSVAAVEERL R-------------------------GRETL-LPWSGLSEGTGSSSNTPEETDD-VDNSS LVASSS-----------------------------------MSVAPWAGAATPLL----P TE----NGEGRLRVIVGREADSSS----------------XXXXXX-------------- --------------------XXXX-----------------------------XX-TETS WQIEINEAKRKLMENILL---YKEEKLD-------------------------------- -----SIELFGP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_nigroviridis_ENSTNIP00000013614 CAKPASDPEEY-ATKLRAATREKLKKFNSLRGRQVQPGEFWDVVVLTAVDGDQRGAYELQ MAEKVKRKELPRGPHYKIFSDPPGCKIGNGGSTLYALQQLSDAYGEALSSLRVLLIH--- --ADEWKKKVGESYAVIIERLDDDLQLKDSELADLRLAFSSDEAFQKV-----------N LSYRTEKGLSLLHLCCVCEGSKAHIRTLILKGLRP--------SRLSRNGFTALHLAAYK DN---------------------------AELVTALLHGG-SDVQQVGYGALTALHVATL AGHHEATDILLQHGANVNVQDAVFFTPLHIASCYGHEQVAKLLLKFGADENVSGEVGDRP LHL----AAAKGFL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SIV KLLVEEGSKAK-----VNAKDNEDHIPLHFSARFGHHEVVRFLLQGNFDVQPHAV--NIY GDTPLHLACYNGKFESVKEIVQLSGTDGLSKENIFSETVLHRQCVHYGKDLEMVKF---- ----------------------------------------LLSQNAMSINHQGRDGHTAL HSACFHGHIRLVQFLLDNGADMNLVA----------------CDPSRSSGE--------- -------------KDEQTCLMWAYEKGHDAIVTLLKHY-K---RP-DDSPCNEYSQPGGA SDGSYVS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------VPSPLGKIKSMTKE KA-EVLLLRVSLPSHFHL-QMSELEFNEIIGSGSFGRVYRGKC------RNK--IVAIKR YRA---NTYC---SK--SDVDMFCR---EVSILCC--LNHPCIIQFVGACLDDPSQFAIV TQYVSGGSLFSLL-HEQK-------RLIDMQSKLIIAIDVA--KGMEYLH----NLTQPI IHRDLNSHNILLYE--------DGHAGLADFGESRFLQS--------VDE----D----- --------NMT-KQPGNLRWMAPEVFTQCTR--YSVKADMFSYALCLWELFT-GEIPFAH LK----PAA--AAADMAYH------H-IR------------------------------- ------------------------PPIG----YSIPKP-ISTLLM--RGWYACPERREEF G---------------------------------------------E-KEDVYNENECEK Q-LMAPASSNSSGSLSPSSSSDCLLGRGGPG-RSHVAALRSRFE-LEYALNTRAYAYWSQ SE-RRRAS---------------------------------------------------- -GGLSLEEVRKNMQRSPIDRNGYVSDPMSTMRCSSSFSSGGSFEDSN------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >H_sapiens_ENSP00000359928 MAAARDPP----EVSLREATQRKLRRFSELRGKLVARGEFWDIVAITAADEKQELAYNQQ LSEKLKRKELPLGVQYHVFVDPAGAKIGNGGSTLCALQCLEKLYGDKWNSFTILLIH--- --SDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKV-----------N LNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRP--------SRLTRNGFTALHLAVYK DN---------------------------AELITSLLHSG-ADIQQVGYGGLTALHIATI AGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRP LHL----ASAKGFL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NIA KLLMEEGSKAD-----VNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVV--NIY GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACT-YGKSIDLVKF---- ----------------------------------------LLDQNVININHQGRDGHTGL HSACYHGHIRLVQFLLDNGADMNLVA----------------CDPSRSSGE--------- -------------KDEQTCLMWAYEKGHDAIVTLLKHY-K---RPQDELPCNEYSQPGG- -DGSYVS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------VPSPLGKIKSMTKE KA-DILLLRAGLPSHFHL-QLSEIEFHEIIGSGSFGKVYKGRC------RNK--IVAIKR YRA---NTYC---SK--SDVDMFCR---EVSILCQ--LNHPCVIQFVGACLNDPSQFAIV TQYISGGSLFSLL-HEQK-------RILDLQSKLIIAVDVA--KGMEYLH----NLTQPI IHRDLNSHNILLYE--------DGHAVVADFGESRFLQS--------LDE----D----- --------NMT-KQPGNLRWMAPEVFTQCTR--YTIKADVFSYALCLWEILT-GEIPFAH LK----PAA--AAADMAYH------H-IR------------------------------- ------------------------PPIG----YSIPKP-ISSLLI--RGWNACPEGRPEF S---------------------------------------------E-VVMKLEECLCNI E-LMSPASSNSSGSLSPSSSSDCLVNRGGPG-RSHVAALRSRFE-LEYALNARSYAALSQ SA-GQYSS---------------------------------------------------- -QGLSLEEMKRSLQYTPIDKYGYVSDPMSSMHFHSCRNSS-SFEDSS------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_rubripes_ENSTRUP00000033221 ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------CVFSGFLHPQWEEVSSY DENLNTIRTYQVCNVFE-PSQNNWLLTTFVDRR-GAQRIYVEIRFTVRDCSSIPNV--PG SCKETFNFYYYETDAVIATKSTAFWMEAPYLKVDTIAADESFSQVDFDGRLMKVNTEVRS FGPLSKNGFYLAF-QDYGACMSL-LSVRVFYKKCPSVVQNFAI---FPETMTG-AESTSL VIARGICIPNSEEV-----DVPIKLYCNGDGEWM-VPIGSCTCKAGFEH-DNGNVCRGPC GAALLGLPPAVSPGTCEAKRLMSISCFQHWFPSIHQKSHMFLCVPSPLDGQRKHSFLPIK RITFLKKELLLPLLMHLVSVAHLPLPSFRACPPGTFKSTQGPGLCLQCPPN--------S RSTAEAATV---C----VCRNGYYRGDADQPDEPCTSVP-----SSPRNVISIV---NET SVILEWHPPRETGGRGDVVYNIVCKKCRA---DRRACSHCDDNVD-FVPRQ-LGLTETRV FISNLLAHTLY--------SFEIQAVNGVSN-------KSPYPAQHVSIDITTNQA---- -----------A----------------------------PSIVP--------------- -IMHQI-SSTMNSFTLSWPQP-EQPNGIIL--DYELRYYEK------------------- ---------------DNRQ-KS-NYPKGRGN----EGPSPAASSSLWCVRVRVCVW-GGG GSVSAAGVVQTSSAD-DFKSE-------L----------------REQLPLIAG-SAAAG VVFIV-SLVAISIIC-SRFRPRP------------------------------------- -------------------------ASDRSAVIRPRLRSLSSCLLSIFMPPSGLFPQLLA RLFPPPPPPCAQLICGCIRAIRETDIRLNARHCCRVQGSPGMKIYIDPFTYEDPNEAVRE FA-------------KEI-DVSTVKIEEVIGAGEFGEVYKGRLKLPGK-REL--YVAIKT LKSGY--------VE--KQRRDFLS---EASIMGQ--FDHPNIIRLEGVVTKS-RPVMIV TEFMENGALDSFL-RQND-------GQFTVIQLVGMMRGIS--AGMKYLS---EM---NY VHRDLAARNILVNS--------NLVCKVSDFGLSRYLQE----DTSDPSY---------- --------TSSLGGKIPVRWTAPEAI-AYRK--FTSASDVWSYGIVMWEVMSFGERPYWD MS----NQD--VINAIEQD--------YR------------------------------- ------------------------LPPP----MDCPST-LHQLML--DCWQKDRNVRPRF A---------------------------------------------D-IVSTLDKMIRNP T--------SLKAVANIPSV--------SIP-DFNTFSSVEDWLGAIKMSQYRDNFLNSG FTSLQLVA---------------------------------------------------- --QMTSE----DLLRIGVTLAGHQKKILSNIQSMRVQM---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >G_gallus_ENSGALP00000015199 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MSSTSAS FV--------------QI-RFDDLQFFENCGGGSFGSVYRARWI----SQDK--EVAVKK LLK-------------------IEK---EAEILSV--LSHKNIIQFYGAVIEP-PNYGIV TEYASAGSLFDYI-NSNK------SEEMDMDHIMTWATDIA--KGMHYLH---MEAPVKV IHRDLKSRNVVIAA--------DGVLKICDFGASRFHSH--------TTH---------- ---------MS-L-VGTFPWMAPEVI-QSLP--VSETCDTYSYGVVLWEMLT-REVPFKG LE----GLQ--VAWLVVEK------N-ER------------------------------- ------------------------LTIP----SSCPRS-FAELMH--QCWEADSKKRPSF K---------------------------------------------Q-IISILESMSNDS N-LPDQCNSFLHNKAEWRCEIEATLERLKKL-ERDLSFKEQELKERERRLKMWEQKLTEQ SNTPLLP-----------------------SFDICAWTE-EDVFFWMQQLTRKG---DAS GEMSAYASLFKEH-----HITGKRLLLLEEE----DLKDMGIISRGHIIHLKTAIEKLTH DYLNLFHFPPLIKDSAGEAEENIEKVVNLELVFG-YHLKLGNGPKDCKWKMYMEMDGDEI AITYIKDVTFNTNLPDVEILKMTKPPFVMEKWIVGIEEHQSVECIVTYESDVRAPKSTRH VQAICWSKVKAQDEVKAVQLMIQTSLPNSEGHSRSRSVSSIDSQWMQTL------RMHQI AKA-ISLQ------HGDPHSPTTVSHYLPYLQSQD-SYAAAVRRTRGPVNY-HYTS-ISH SRNSSPLSHSLVRNLSSLHI-NSKGSSTSSTASDTASE--RDRSTGKARNASHSGNS--R SSSDGRRSGT---SSPVPPRSSGRAGRTASMPPAHEQ----RRYPR--NSPQPKAIPGMP LQG---ESEPRRSEGEGRASEGGWIKVQHVK--KPHRQ-STGKQGKERPKGSWRGRRAF- --------------------------------------------------- >A_carolinensis_ENSACAP00000009324 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------ACPAGMFKANQGAGICTQCPPN--------S RSTSEAAPI---C----TCRNGYYRADFDPSEVACTSVP-----SGPRNVISIV---NET SIILEWHPPRETGGREDVTYNIVCKKCRS---DRRSCSRCDDNVE-FVPRQ-LGLTETRV FISNLWAHTPY--------TFEIQAVNGVSN-------KSPFPPQHVSVNITTNQA---- -----------A----------------------------PSTVP--------------- -IMHQV-SATMRSITLSWPQP-EQPNGIIL--DYEIRYYEK------------------- ---------------DHSEYNS-SMAKSQTNTARIDGLRP---GMVYVVQVRARTV-AGY GKYSGKMCFQTLTDD-DYKSE-------L----------------REQLPLIAG-SAAAG VVFIV-SLVAISIVC-SRKR---------------------------------------- -------------------------AYSKEAVYSDKLQHYSTGR---------------- -------------------------------------GSPGMKIYIDPFTYEDPNEAVRE FA-------------KEI-DVSFVKIEEVIGAGEFGEVYKGRLKLPGK-REI--YVAIKT LKAGY--------SE--KQRRDFLS---EASIMGQ--FDHPNIIRLEGVVTKS-RPVMII TEFMENGALDSFL-RQND-------GQFTVIQLVGMLRGIA--AGMKYLA---EM---NY VHRDLAARNILVNS--------NLVCKVSDFGLSRYLQD----DTSDPTY---------- --------TSSLGGKIPVRWTAPEAI-AYRK--FTSASDVWSYGIVMWEVMSFGERPYWD MS----NQD--VINAIEQD--------YR------------------------------- ------------------------LPPP----MDCPAA-LHQLML--DCWQKDRNTRPRF A---------------------------------------------E-IVNTLDKMIRNP A--------SLKTVATITTVPSQPLLDRSIP-DFTAFTSVEDWLSAIKMNQYRDSFLTAG FTSLQLVA---------------------------------------------------- --QMTSE----DLLRIGVTLAGHQKKILNSVQSMRVQMSQSPTSMA-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >M_domestica_ENSMODP00000023092 ------------------------------------------------------------ ------------------------------------------------------------ ---------VVRIVNSFSFLFSLPETLMDTRTATAELGW--TANPASGVSTGEWEEVSGY DENLNTIRTYQVCNVFE-PNQNNWLLTTFIHRR-GAHRIYTEMRFTVRDCSSLPNV--PG SCKETFNLYYYETDSVIATKKSAFWTEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRS FGPLTRNGFYLAF-QDYGACMSL-LSVRVFFKKCPSIVQNFAI---FPETMTG-AESTSL VIARGTCIPNAEEV-----DVPIKLYCNGDGEWM-VPIGRCTCKAGYEP-ENNVVC---- ------------------------------------------------------------ ----------------------------KACPAGMFKANQEVGVCSQCPSN--------S RSPSEASPI---C----TCRTGYYRADFDPPEVACTSVP-----SGPRNVISIV---NET SIILEWHPPRETGGRDDVTYNIVCKKCRA---DRRSCSRCDDNVE-FVPRQ-LGLTESRV FISSLWAHTPY--------TFDIQAINGVSG-------KSPFPPQHVSVNITTNQAGESS FLPPVLSSLSTA----------------------------PSTVP--------------- -IMHQV-SATMRSITLSWPQP-EQPNGIIL--DYEIRYYEK------------------- ---------------EQNEYNS-SMAKSQTNTARIDGLRP---GMVYVVQVRARTV-AGY GKYSGKMCFQTLTDG-EW--E-------L----------------REQLPLIAG-SAAAG VVFIV-SLVAISIVC-SRKR---------------------------------------- -------------------------AYSKEAVYSDKLQHYSTGR---------------- ----------------------------------------GMKIYIDPFTYEDPNEAVRE FA-------------KEI-DVSFVKIEEVIGAGEFGEVYKGRLKLPGK-REI--YVAIKT LKAGY--------SE--KQRRDFLS---EASIMGQ--FDHPNIIRLEGVVTKS-RPVMII TEFMENGALDSFL-RQND-------GQFTVIQLVGMLRGIA--AGMKYLS---EM---NY VHRDLAARNILVNS--------NLVCKVSDFGLSRYLQD----DTSDPTY---------- --------TSSLGGKIPVRWTAPEAI-AYRK--FTSASDVWSYGIVMWEVMSFGERPYWD MS----NQD--VINAIEQD--------YR------------------------------- ------------------------LPPP----MDCPAA-LHQLML--DCWQKDRNTRPRF T---------------------------------------------E-IVNTLDKMIRNP A--------SLKTVATITAVPSQPLLDRSIP-DFTAFTSVDDWLNAIKMVQYRDSFLTAG FTSLQLVT---------------------------------------------------- --QMTSE----DLLRIGVTLAGHQKKILNSVHSMRVQ----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >O_latipes_ENSORLP00000004965 V---VSMSEVC-GGKLPTSTRKKIRKFSSLRG-EVQSGDFWDVVVVTAVDGGQKEAYEAQ ISEKIDRRELPLGTTYKVFSDPPGPKIGNGGSTLHALQQLKSVYGEALSRLRVILIH--- --ADEWKKKVAEFYSVIMEKLEDDFQLPESQLPDLELAFSSDEAFQKV-----------N VSYRTEKGLSLLHLCCVCGGSKAHVRTLMLKGLRP--------SRLSRNGFTALHLAAFK DN---------------------------AQLVTALLHGG-ADVQQVGYGALTALHVATL AGHHETADILLQHGANVNVQDAVFFTPLHIASYKGHEQVTKLLLKFGADVNASGEVGDRP LHL----AAAKGFL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------AIV KLLMGDGSKAN-----ANAQDNEDHVPLHFCTRYGHHEIIRFLLQGNFDIQPHSV--NIY GDTPLHLACYNGKVAAVKELVQLSGPESLPKENIFSETALHSACT-YGKDLEMVKF---- ----------------------------------------LLNQNAMSINYQGRDGHTAL HSACFHGHIRLVQFLLDSGADMNLVA----------------CDPSRSSGE--------- -------------KDEQTCLMWAYEKGHDAIVTLLKHY-K---RP-DDSPCNEYSQPGG- -DGSYVS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------VPSPLGKIKSMTKE KA-EVLVLRASLPSHFHL-QLSELEFNEIIGSGSFGRVYRGKC------RNK--IVAIKR YRA---NTYC---SK--SDVDMFCR---EVSILCR--LNHPCIIQFVGACLDDPSQFAIV TQYISGGSLFSLL-HEQK-------RLIDLQSKLIIAIDVA--KGMEYLH----NLTQPI IHRDLNSHNILLYE--------DGHAVVADFGESRFLQS--------VDE----D----- --------NMT-KQPGNLRWMAPEVFTQCTR--YSVKADMFSYALCLWELLT-GEIPFAH LK----PAA--AAADMAYH------H-IR------------------------------- ------------------------PPLG----YSIPKP-ISALLM--RGWNSCPEDRPEF S---------------------------------------------E-VVSSLEECLCNA E-FMSPASSNSSGSLSPSSSSDCLLARGGPG-RSHVAALRSRFE-LEHALNTRAYAFWTQ SE-RRRAS---------------------------------------------------- -GGLSLEELRRNMQFSPIDRNGYVSDPMSTMRFCSSFSSSGSFEDSN------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >A_carolinensis_ENSACAP00000012866 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------PNPV--WMAVFD YEATAEEELTLRR--------------------------------------------GDR VEV----LSKDSTV---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SGD EGWWTGK-LQDKVGIFPSNYVTSN------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------HKYTQIQGS LTCPPP---------LEI-SFQELELDEIIGVGGFGKVYKGLW------RGE--EVAVKA TRQD--PEED---IA--VTAENVRQ---EARLFAM--LQHPNIIALKAVCLNL-PHLCLV MEYARGGALNRAL-AGKK---------VPPHVLVNWAVQIA--RGMNYLH---NEAIVPI IHRDLKSINILILERIENEDLSSCTLKITDFGLAREWHK--------TTK---------- ---------MS-A-AGTYAWMAPEVI-RHSL--FSKSSDVWSFGVLLWELLT-GEVPYRE ID----ALA--VAYGVAMN------K-LT------------------------------- ------------------------LPIP----STCPEP-FACLLE--ECWSPDPHSRPDF S---------------------------------------------S-ILQQLVAIEQSA M-FQMPLESFHSLQQDWKVEIAGMFLDLRTK-EKELRSREEELLRAAQEQKTQEAELRRR EQELAEREIDIVERELNLIMMQMGQERPRVKKRKGHFRRSRLKL--RD-GNRISLPSGFE HKITVQASPTLDCRKGLGANGASPPGSPNIIPRLRAIRLTPLDGNRTWGRSTTIKKEELV ----GTKKKGRTWGPSSTGLKPEGKCDNGAAGREAKAGSAFQIGVIFFFDLYRLKSLAEG SKQWSSSAPNLGKSPKHMPLAGGFASLNEM------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >P_pygmaeus_ENSPPYP00000014446 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MSSLGAS FV--------------QI-KFDDLQFFENCGGGSFGSVYRAKWI----SQDK--EVAVKK LLK-------------------IEK---EAEILSV--LSHRNIIQFYGVILEP-PNYGIV TEYASLGSLYDYI-NSNR------SEEMDMDHIMTWATDVA--KGMHYLH---MEAPVKV IHRDLKSRNVVIAA--------DGVLKICDFGASRFHNH--------TTH---------- ---------MS-L-VGTFPWMAPEVI-QSLP--VSETCDTYSYGVVLWEMLT-REVPFKG LE----GLQ--VAWLVVEK------N-ER------------------------------- ------------------------LTIP----SSCPRS-FAELLH--QCWEADAKKRPSF K---------------------------------------------Q-IISILESMSNDT S-LPDKCNSFLHNKAEWRCEIEATLERLKKL-ERDLSFKEQELKERERRLKMWEQKLTEQ SNTPLL-------------------------LPLAARMS-EESYFESKTEE------SNS AEMSCQITATSNGEGHGMNPSLQAMMLMGFG----DIFSMN--KAGAVMHSGMQINMQAK ------------QNSSKTTSKRRGKKVNMALGFSDFDLSEGDDDDDD------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------DDDGEEEDNDMDNSE--------------------------------------- --------------------------------------------------- >T_guttata_ENSTGUP00000008928 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MSSTSAS FV--------------QI-KFDDLQFFENCGGGSFGSVYRARWI----SQDK--EVAVKK LLK-------------------IEK---EAEILSV--LSHKNIIQFYGAVIEP-PNYGIV TEYASAGSLFDYI-NSNK------SEEMDMDHIMTWATDIA--KGMHYLH---MEAPVKV IHRDLKSRNVVIAA--------DGVLKICDFGASRFHSH--------TTH---------- ---------MS-L-VGTFPWMAPEVI-QSLP--VSETCDTYSYGVVLWEMLT-REVPFKG LE----GLQ--VAWLVVEK------N-ER------------------------------- ------------------------LTIP----SSCPRS-FAELMH--QCWDADSKKRPSF K---------------------------------------------Q-IISILESMSNDS N-LPDQCNSFLHNKAEWRCEIEATLERLKKL-ERDLSFKEQELKERERRLKMWEQKLTEQ SNTPLLP-----------------------SFDICAWTE-EDVFFWMQQLTRKG---DTS GEMSVYASLFKEH-----HITGKQLLLLEEE----DLKDMGIVSRGHIIHLKTAIEKLTH DYLNLFHFPPLIKASG--AEESIEKIVNLELVFG-YHLKPGNGPKDCKWKMYMEMDGDEI AITYIKDVTFNTNLPDVEILKMTKPPFVMEKWIVGIEEHQSVECVVTYESDVRAPKSTRH IQAICWSKLKAQDEVEAVQLLIQTSLPNSEGNSRSRSDSGTDSQWMQTL------RMQQL AKA-ISLQ------HGHPHSPTTVTQYLPYLRSQD-SYAAAVRRTRAPVAQ-QLTS-ISH SRNSSPLSHSLMRNISNLHL-NSKGSSASSTASDTPSE--RDRSAGKGRAASHGAAS--R SSSGGRRSGA---GSPLPPRLSGRPGRTPPPAAAQH-----RRNPR--GPPQPSAIPGMP PQG---DGEPRRGEGDSRASEGGWIKVQHSR--KPHRQ-AAGKPGKERARGSWRGRRMF- --------------------------------------------------- >X_tropicalis_ENSXETP00000030111 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------HRVYVEMRFTVRDCSSLPNV--PG SCKETFNLYYYETDSNIDNKISTFWNESPYLKVDTIAADESFSQVDFGGRLMKVNTEVRS FGPLTRSGFYLAF-QDYGACMSL-LSVRVFFKKCPSVVQNFAV---FPETMTG-AESTSL VIARGTCIPNAEEV-----DVPIKLYCNGDGEWM-VPIGKCTCKAGYEP-ENHVVC---- ------------------------------------------------------------ ----------------------------KACPAAMFKANQGMGVCAPCPAN--------S RSTSEASPI---C----ICRNGYYRADFDTPEAPCTSVP-----SGPRNVISIV---NET AITLEWHPPRETGGRDDVTYNIICKKCQS---DRRGCSRCDDNVE-FVPRQ-MGLTDTRV FISNLWAHTPY--------TFEIQAINGVTN-------KSPFPPQHVSVNITTNQA---- -----------A----------------------------PSSVP--------------- -IMHQV-KATMKSITLSWPQP-EQPNGIIL--DYEIRYYEK------------------- ---------------DHHEFNS-SLARSQTNTASIEGLRP---GVVYVVQVRARTV-AGY GKFSSKMCFQTLTAE-DYKSE-------L----------------REQLPLIAG-SAAAG VVFIV-SLVAISIVC-SRKR---------------------------------------- -------------------------TYSKEAVYSDKLQHYSTGR---------------- -------------------------------------GSPGMKIYIDPFTYEDPNEAVRE FA-------------KEI-DVSFVKIEEVIGAGEFGEVYKGRLKLPSK-REI--YVAIKT LKAGY--------SE--KQRRDFLS---EASIMGQ--FDHPNIIRLEGVVTKS-RPVMII TEFMENGALDSFL-RQND-------GQFTVIQLVGMLRGIA--AGMKYLS---EM---NY VHRDLAARNILVNS--------NLVCKVSDFGLSRYLQD----DTSDPTY---------- --------TSSLGGKIPVRWTAPEAI-AYRK--FTSASDVWSYGIVMWEVMSYGERPYWD MS----NQD--VINAIEQD--------YR------------------------------- ------------------------LPPP----MDCPAA-LHQLML--DCWQKDRNSRPRF G---------------------------------------------E-IVNTLDKMIRNP A--------SLKTVATIPAVPSQPLLDHSIP-DITAFTSVDDWLSAIKMGQYRDIFLSSG FTSLQLVA---------------------------------------------------- --QMTSE----DLLRIGITLAGHQKKILNSIQSMRVQISQSPTSIA-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >G_gallus_ENSGALP00000010654 ------------------------------------------------------------ ------------------------------------------------------------ ----FYMLLLSLLLLLLFFFSLYKKTLMDTRTATAELGW--TANPPSG-----WEEVSGY DENLNTIRTYQVCNVFE-PNQNNWLLTTFINRR-GAHRIYTEMRFTVRDCSSLPNV--PG SCKETFNLYYYETDSVIATKKSAFWTEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRS FGPLTRNGFYLAF-QDYGACMSL-LSVRVFFKKCPSVVQNFAI---FPETMTG-AESTSL VTARGTCIPNAEEV-----DVPIKLYCNGDGEWM-VPIGRCTCKAGYEP-ENNVAC---- ------------------------------------------------------------ ----------------------------KACPAGTFKASQGAGLCAPCPPN--------S RSSAEASPL---C----ACRNGYFRADLDPPTAACTSVP-----SGPRNVISIV---NET SIILEWNPPRETGGRDDVTYNIVCKKCRA---DRRACSRCDDNVE-FVPRQ-LGLTETRV FISSLWAHTPY--------TFEIQAVNGVSN-------KSPFPPQHVSVNITTNQA---- -----------A----------------------------PSTVP--------------- -IMHQV-SATMRSITLSWPQP-EQPNGIIL--DYELRYYEK------------------- ---------------DHNEYNS-SVARSQTNTARLEGLRP---GMVYVVQVRARTV-AGY GKYSGKMCFQTLTDD-DYKSE-------L----------------REQLPLIAG-SAAAG VVFIV-SLVAISIVC-SRKR---------------------------------------- -------------------------AYSKEAVYSDKLQHYSTGR---------------- -----------------------------------AQGSPGMKIYIDPFTYEDPNEAVRE FA-------------KEI-DVSFVKIEEVIGAGEFGEVYKGRLKLPGK-REI--YVAIKT LKAGY--------SE--KQRRDFLS---EASIMGQ--FDHPNIIRLEGVVTKS-RPVMII TEFMENGALDSFL-RQND-------GQFTVIQLVGMLRGIA--AGMKYLA---EM---NY VHRDLAARNILVNS--------NLVCKVSDFGLSRYLQD----DTSDPTY---------- --------TSSLGGKIPVRWTAPEAI-AYRK--FTSASDVWSYGIVMWEVMSFGERPYWD MS----NQD--VINAIEQD--------YR------------------------------- ------------------------LPPP----MDCPAA-LHQLML--DCWQKDRNTRPRF A---------------------------------------------E-IVNTLDKMIRNP A--------SLKTVATITAVPSQPLLDRSIP-DFTAFTSVEDWLSAVKMSQYRDNFLSAG FTSLQLVA---------------------------------------------------- --QMTSE----DLLRIGVTLAGHQKKILNSIQSMRVQMSQSPTSMA-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >G_aculeatus_ENSGACP00000018485 ------------------------------------------------------------ ------------------------------------------------------------ -------PRLTAVFVYLLFSPFSAETVMDTRVATAELGW--TAYPNSG-----WEEVSGY DENLNTIRTYQVCNVFE-PSQNNWLLTTFIDRR-GAQRIYVEIRFTVRDCSSIPNV--PG SCKETFNLYYYETDAVIATKGTAFWMEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRS FGPLSKNGFYLAF-QDYGACMSL-LSVRVFYKKCPSVVQNFAI---FPETMTG-AESTSL VIARGVCIPNSEEV-----DVPIKLYCNGDGEWM-VPIGSCTCKAGFEP-DNGNVC---- ------------------------------------------------------------ ----------------------------RACPPGTFKSTQGPGLCLQCPPN--------S RSTAEAATI---C----VCRNGYYRGDGDQPDEPCTSVP-----SSPRNVISIV---NET SVILEWHSPRETGGREDVVYNIVCKKCRA---DRRSCSHCDDNVD-FVPRQ-LGLTDTRV FISNLWAHTLY--------SFEIQAVNGVSN-------RSPYPSQHVSIDITTNQA---- -----------A----------------------------PSIVP--------------- -IMHQI-SSTMNSFTLSWPQP-EQPNGIIL--DYELRYYEK------------------- ---------------DHAEINS-TILRSQTNTARVEGLRP---GTVYVVQVRARTV-AGF GKYSSKMCFQTLTDD-DFKSE-------L----------------REQLPLIAG-SAAAG VVFIV-SLVAISIVC-SRKR---------------------------------------- -------------------------AYTKEAVYSDKLQHYSTGR---------------- -------------------------------------GSPGMKIYIDPFTYEDPNEAVRE FA-------------KEI-DVSTVKIEEVIGAGEFGEVYKGRLKLPGK-REI--YVAIKT LKAGY--------AE--KQRRDFLA---EASIMGQ--FDHPNIIRLEGVVTKS-RPVMIV TEFMENGALDSFL-RQND-------GQFTVIQLVGMMRGIS--AGMKYLS---EM---NY VHRDLAARNILVNS--------NLVCKVSDFGLSRYLQD----DTSDPSY---------- --------TSSLGGKIPVRWTAPEAI-AYRK--FTSASDVWSYGIVMWEVMSFGERPYWD MS----NQD--VINAIEQD--------YR------------------------------- ------------------------LPPP----MDCPSA-LHQLML--DCWQKDRNVRPRF S---------------------------------------------D-IVSTLDKMIRNP T--------SLKAVANIPAVPSQPLLDRSIP-DFNSFSSVEDWLAAIKMSQYRDNFLNSG FTSLQLVA---------------------------------------------------- --QMTSE----DLLRIGVTLAGHQKKILSNIQTMRVQMSQSPTTMA-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >P_pygmaeus_ENSPPYP00000001439 MAAAGVPP----VVSLREATQRKLRRFSELRGKLVAPGEFWDIVAITAADEKQELAYNQQ LSEKLKRKELPLGVQYHVFVDPAGAKIGNGGSTLCALQCLEKLYGDKWNSFTILLIH--- --SDEWKKKVSESYVITIERLEDDLKIKEKEPTELRNIFGSDEAFSKV-----------N LNYHTENGLSLLHLCCICGGNKSHIRTLMLKGLRP--------SRLTRNGFTALHLAVYK DN---------------------------AELITSLLHGG-ADIQQVGYGGLTALHIATI AGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRP LHL----ASAKGFL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NIA KLLMEEGSKAD-----VNAQDNEDHVPLHFCSRFGHHDIVKYLLQNDLEVQPHVV--NIY GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACT-YGKSIDLVKF---- ----------------------------------------LLDQNVININHQGRDGHTGL HSACYHGHIHLVQFLLDNGADMNLVA----------------CDPSRSSGE--------- -------------KDEQTCLMWAYEKGHDAIVTLLKHY-K---RPQDELPCNEYSQPGG- -DGSYVS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------VPSPLGKIKSMTKE KA-DILLLRAGLPSHFHL-QLSEIEFHEIIGSGSFGKVYKGRC------RNK--IVAIKR YRA---NTYC---SK--SDVDMFCR---EVSILCQ--LNHPCVIQFVGACLNDPSQFAIV TQYISGGSLFSLL-HEQK-------RILDLQSKLIIAVDVA--RGMEYLH----NLTQPI IHRDLNSHNILLYE--------DGHAVVADFGESRFLQS--------LDE----D----- --------NMT-KQPGNLRWMAPEVFTQCTR--YTIKADVFSYALCLWEILT-GEIPFAH LK----PAA--AAADMAYH------H-IR------------------------------- ------------------------PPIG----YSIPKP-ISSLLI--RGWNACPEGRPEF S---------------------------------------------E-VVMKLEECLCNI E-LMSPASSNSSGSLSPSSSSDCLVSRGGPG-RSHVAALRSRFE-LEYALNARSYAALSQ SA-GQYSS---------------------------------------------------- -QGLSLEEMKRSLQYTPIDKYGYVSDPMSPMHFHSCRNSS-SFEDSS------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_rubripes_ENSTRUP00000045209 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MLSPSAS FV--------------QI-KFDDILFHENCGDGSFGSVYRARWI----SQDK--EVAVKK LLK-------------------IEN---EAEILSV--LSHRNIIQFYGAVVEA-PNYGIV TEYASGGSLYDYL-SSAE------SERMDMGQIMTWAAEIA--RGMHYLH---SEAPVKV IHRDLKSRNVVVTA--------DKVLKICDFGASKFLTH--------TTH---------- ---------MS-L-VGTFPWMAPEVI-QSLP--VSETCDTFSFGVVLWEMLT-SEIPFKG LE----GLQ--VAWLVVEK------N-ER------------------------------- ------------------------LTIP----SGCPAS-FAELMR--SCWASEPKERPMF K---------------------------------------------Q-ILATLESMSNDS Q-LPQQCNSFLHNKAEWRCEIEATLERLKKL-ERDLSTKEQELKEREQRLKMWERKLIEQ SSSPLLP-----------------------THDIYTWTE-EHVYFWMQQIFGAE---EGP CGMQVYANLFKEN-----HITGKRLLLLTES----DMRDMGVKSKGHVMHLKGEIEKLTH DYLSLVHFPPLLKEEL-EKQVEMSKTIKLELVFG-YHWKPGTGKDDCKWKMYIELDGDDV AVTYIKDVVFNTNRADMETLRMAKPPFVMEKWITGIQPNQRVDYTVNYENDVKLPKSTRH SCPMTWSLIGGQNEIKTVELVIETTPAKIDCNPKDKDNFNIDPIWMCKV------RQRQT ISQ-KSQESPSALTAFTSSDARTLPQFLSAHERQEFSYAAAVRRS---PNRSHLTP-WGD SRSSSPTA-SLSAKLSPLRL-GSKGSSPSSTTSESTLERDRERPQSAGVVQDYGRNR-YN FSNFGRGQGRGQASATSRGNYFNNKTSKAVRQPGRPRSNSYSVTPQ----NCPTMIPGIL SV----TENPSGEKNGPKASDGGWIKVERQK----RLARQDNKQVRGRQRRGSRGGRGA- --------------------------------------------------- >O_latipes_ENSORLP00000019993 ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GWQVTLHPQGG-----WEEVSGY NENLNTIRTYQVCNVFE-PSQNNWLLTTFIDRK-GAQRIYVEIRFTVRDCSSIPNV--PG SCKETFNLYYYETDAVIATKGTAFWMEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRS FGPLSKNGFYLAF-QDYGACMSL-LSVRVFYKKCPSVVQNFAV---FPETMTG-AESTSL VIARGNCIPNSEEV-----DVPIKLYCNGDGEWM-VPIGSCTCKAGFEP-DNGNVC---- ------------------------------------------------------------ ----------------------------RACPPGTFKSTQGPSLCLQCPLN--------S RSTAEAATV---C----VCRNGYYRGDADQPDEPCTSVP-----SSPRNVISIV---NET SVILEWHSPRETGGRDDVVYNIVCKKCRA---DRRSCSHCDDNVD-FVPRQ-LGLTETRV FISNLLSHTLY--------SFEIQAVNGVSN-------KSPYPAQHVTIDITTNQA---- -----------A----------------------------PSIVP--------------- -IMHQI-SSTMNSFTLSWPQP-EQPNGIIL--DYELRYYEK------------------- ---------------DHAEINS-TTLRCQTNTARVEGLRP---GTVYVVQVRARTV-AGF GRYSSKMCFQTLTDD-DFKSE-------L----------------REQLPLIAG-SAAAG VVFIV-SLIAISIVC-SRKR---------------------------------------- -------------------------AYTKEAVYSDKLQHYSTGR---------------- ------------------VTFRITEISLGPKTV----CSPGMKIYIDPFTYEDPNEAVRE FA-------------KEI-DVSTVKIEEVIGAGEFGEVYKGRLKLPGK-REI--FVAIKT LKAGY--------VE--KQRRDFLS---EASIMGQ--FDHPNIIRLEGVVTKS-RPVMIL TEFMENGALDSFL-RQND-------GQFTVIQLVGMMRGIA--AGMKYLS---EM---NY VHRDLAARNILVNS--------NLVCKVSDFGLSRYLQD----DTSDPSY---------- --------TSSLGGKIPVRWTAPEAI-AYRK--FTSASDVWSYGIVMWEVMSFGERPYWD MS----NQD--VINAIEQD--------YR------------------------------- ------------------------LPPP----MDCPSA-LHQLML--DCWQKDRNVRPRF S---------------------------------------------D-IVSTLDKMIRNP T--------SLKAVANIPAVPSQPLLDRSIP-DFNTFSSVEDWLTAIKMGQYRDNFLNSG FTSLQLVA---------------------------------------------------- --QMTSE----DLLRIGVTLAGHQKKILNNIQSMRVQMSQPPNTVA-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >O_latipes_ENSORLP00000004411 ------------------------------------------------------------ -------------------------------------------------------TMALR GFN---LFAFLVVNGVFLSRQSKEEVLLDMRSLGSELGW--LTLP----YENGWEIVQTV -VNGSPLYTYSVCNVDS-SDQDNWLRTTFIQRRSGASRVSVELQFVVRDCNTFGSS--SV ACKETFNLFLAEADADVGTN----FRKGQFRKVATIAPDEITQ-----GNVLKVNTETKT VGSLSKKGFYLAF-QDMGACVAL-LSARVYYKTCPSTVQSLAV---FPETVA-----DSL REVEGVCVENAIGQ-----ATP-RIYCSAEGDWV-VPVGQCQCLPGYETTADS--C---- ------------------------------------------------------------ ----------------------------Q------------GERCQKCATHPSVCVALKT RRLKGNPTAIFRCKEAGPLSDLFFSSPKNPLNSGMALFP-----AAPAENKRTK---ANF KILFLYKKASSFFIKKSLCFSETMDKCP-----PPASRVTPQRLSCWCPGPSAPLQEHEP RVHRSDHLMDFQPSCHPVDTGSVDLRSGLQA---------GEHYDYSLTTICFLTT---- -----------D----------------------------PPKVT--------------- -SIHLE-KSGPTSLSLSWSLS-RRPPAHISH-RYELMYRRK------------------- ------------EAEGERDVTTYTVRILDKSFVQITDLTP---DTTYIFKVQALSPEGTP GSFSTEHEFHTSPLA-EPQ---------I----------------QNSSTAVLG-AVVGV AVILL-AVLAFVV---LRRR---------------------------------------- -------------------------RLSSRGRRGAEDPYFST------------------ ------------------------------------DQLKPLQAYVDPHTYEDPNIAIQK FV-------------TEI-DPNAIAKHKVIGVGEFGEVFRGVMKTQGK-GEV--TVAIKT LKPGY--------SE--KQRQDFLS---EASIMGQ--FSHPNIIHLEGVVTKF-KHAMIV TEYMENGALDTYL-KDHD-------GEMSPYQLLGMLRGIA--AGMKYLS---DM---SY VHRDLAARNVLVNS--------NLECKVSDFGLSRVLED----D-AEGTY---------- --------TTR-GGKIPIRWTAPEAI-AYRK--FTSASDVWSFGIVMWEVMAFGERPYWD MS----NHE--VMKAINEA--------FR------------------------------- ------------------------LPAP----MDCPSA-IYQLML--QCWQQDRAIRPRF A---------------------------------------------D-IVNILDKLLRSP E--------SLKTIADFDPRVSIRLPSTSGG-DGTMFRSVTEWLESIKMSQYKESFARAG ITTMEQVL---------------------------------------------------- --ALRHE----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >M_musculus_ENSMUSP00000035129 ------------------------------------------------------------ ------------------------------------------------------------ -----MALDCLLLFLLASAVAAMEETLMDTRTATAELGW--TANPASG-----WEEVSGY DENLNTIRTYQVCNVFE-PNQNNWLLTTFINRR-GAHRIYTEMRFTVRDCSSLPNV--PG SCKETFNLYYYETDSVIATKKSAFWSEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRS FGPLTRNGFYLAF-QDYGACMSL-LSVRVFFKKCPSIVQNFAV---FPETMTG-AESTSL VIARGTCIPNAEEV-----DVPIKLYCNGDGEWM-VPIGRCTCKPGYEP-ENSVAC---- ------------------------------------------------------------ ----------------------------KACPAGTFKASQEAEGCSHCPSN--------S RSPSEASPI---C----TCRTGYYRADFDPPEVACTSVP-----SGPRNVISIV---NET SIILEWHPPRETGGRDDVTYNIICKKCRA---DRRSCSRCDDNVE-FVPRQ-LGLTECRV SISSLWAHTPY--------TFDIQAINGVSS-------KSPFPPQHVSVNITTNQA---- -----------A----------------------------PSTVP--------------- -IMHQV-SATMRSITLSWPQP-EQPNGIIL--DYEIRYYEK------------------- ---------------EHNEFNS-SMARSQTNTARIDGLRP---GMVYVVQVRARTV-AGY GKFSGKMCFQTLTDD-DYKSE-------L----------------REQLPLIAG-SAAAG VVFVV-SLVAISIVC-SRKR---------------------------------------- -------------------------AYSKEAAYSDKLQHYSTGR---------------- -------------------------------------GSPGMKIYIDPFTYEDPNEAVRE FA-------------KEI-DVSFVKIEEVIGAGEFGEVYKGRLKLPGK-REI--YVAIKT LKAGY--------SE--KQRRDFLS---EASIMGQ--FDHPNIIRLEGVVTKS-RPVMII TEFMENGALDSFL-RQND-------GQFTVIQLVGMLRGIA--AGMKYLS---EM---NY VHRDLAARNILVNS--------NLVCKVSDFGLSRYLQD----DTSDPTY---------- --------TSSLGGKIPVRWTAPEAI-AYRK--FTSASDVWSYGIVMWEVMSFGERPYWD MS----NQD--VINAIEQD--------YR------------------------------- ------------------------LPPP----MDCPAA-LHQLML--DCWQKDRNSRPRF A---------------------------------------------E-IVNTLDKMIRNP A--------SLKTVATITAVPSQPLLDRSIP-DFTAFTTVDDWLSAIKMVQYRDSFLTAG FTSLQLVT---------------------------------------------------- --QMTSE----DLLRIGVTLAGHQKKILSSIHSMRVQMNQSPSVMA-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >R_norvegicus_ENSRNOP00000010634 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------ETLMDTRTATAELGW--TANPASG-----WEEVSGY DENLNTIRTYQVCNVFE-PNQNNWLLTTFINRR-GAHRIYTEMRFTVRDCSSLPNV--PG SCKETFNLYYYETDSVIATKKSAFWSEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRS FGPLTRNGFYLAF-QDYGACMSL-LSVRVFFKKCPSIVQNFAV---FPETMTG-AESTSL VIARGTCIPNAEEV-----DVPIKLYCNGDGEWM-VPIGRCTCKAGYEP-ENSVAC---- ------------------------------------------------------------ ----------------------------KACPAGTFKASQEAEGCSHCPSN--------S RSPSEASPI---C----TCRTGYYRADFDPPEVACTSVP-----SGPRNVISIV---NET SIILEWHPPRETGGRDDVTYNIICKKCRA---DRRSCSRCDDNVE-FVPRQ-LGLTECRV SISSLWAHTPY--------TFDIQAINGVSS-------KSPFPPQHVSVNITTNQA---- -----------A----------------------------PSTVP--------------- -IMHQV-SATMRSITLSWPQP-EQPNGIIL--DYEIRYYEK------------------- ---------------EHNEFNS-SMARSQTNTARIDGLRP---GMVYVVQVRARTV-AGY GKFSGKMCFQTLTDD-DYKSE-------L----------------REQLPLIAG-SAAAG VVFVV-SLVAISIVC-SRKR---------------------------------------- -------------------------AYSKEAVYSDKLQHYSTGR---------------- -------------------------------------GSPGMKIYIDPFTYEDPNEAVRE FA-------------KEI-DVSFVKIEEVIGAGEFGEVYKGRLKLPGK-REI--YVAIKT LKAGY--------SE--KQRRDFLS---EASIMGQ--FDHPNIIRLEGVVTKS-RPVMII TEFMENGALDSFL-RQND-------GQFTVIQLVGMLRGIA--AGMKYLS---EM---NY VHRDLAARNILVNS--------NLVCKVSDFGLSRYLQD----DTSDPTY---------- --------TSSLGGKIPVRWTAPEAI-AYRK--FTSASDVWSYGIVMWEVMSFGERPYWD MS----NQD--VINAIEQD--------YR------------------------------- ------------------------LPPP----MDCPAA-LHQLML--DCWQKDRNSRPRF A---------------------------------------------E-IVNTLDKMIRNP A--------SLKTVATITAVPSQPLLDRSIP-DFTAFTTVDDWLSAIKMVQYRDSFLTAG FTSLQLVT---------------------------------------------------- --QMTSE----DLLRIGVTLAGHQKKILSSIHSMRVQMNQSPSVMA-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >D_rerio_ENSDARP00000096606 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------ACPPGTFKASQGPGLCSQCPAN--------S RSTSEAATI---C----VCRNGYYRADGEQPDMPCTSVP-----SGPRNVISIV---NET SVTLEWHSPRETGGREDVTYNIVCKKCQA---DRRSCSHCDDNVE-FQPRQ-LGLTESRV FISNLLAHTLY--------TFEIQAVNGVSN-------KSPYPAQHVSIDITTNQA---- -----------A----------------------------PSIVP--------------- -IMHQV-SSTMKSITLSWPQP-EQPNGIIL--DYELRYYEK------------------- ---------------ELSEVNS-TQMRSQTNTARVDGLRP---GTMYVMQVRARTV-AGF GKYSSKMCFQTLTDD-DYKSE-------L----------------REQLPLIAG-SAAAG VVFIV-SLVAISIVC-RRKR---------------------------------------- -------------------------AYNKEAVYSDKLQHYSTGR---------------- -------------------------------------GSPGMKIYIDPFTYEDPNEAVRE FA-------------KEI-DVSTVKIEEVIGAGEFGEVYKGRLKLPGK-REL--YVAIKT LKAGY--------SE--KQRRDFLS---EASIMGQ--FDHPNIIRLEGVVTKS-RPVMIV TEFMENGALDSFL-RQND-------GQFTVIQLVGMLRGIA--AGMKYLS---EM---NY VHRDLAARNILVNS--------NLVCKVSDFGLSRYLQE----DTSDPTY---------- --------TSSLGGKIPVRWTSPEAI-AYRK--FTSASDVWSYGIVMWEVMSFGERPYWD MS----NQD--VINAIEQD--------YR------------------------------- ------------------------LPPP----MDCPTA-LHQLML--DCWQKDRNARPRF T---------------------------------------------D-IVNTLDKLIRNP T--------SLKAVASIPTIPSQPLLDRSIP-DFTTFSSVEDWLAAVKMSQYRDNFLNSG FTSLQLVT---------------------------------------------------- --QMTSE----DLLRIGVTLAGHQKKILNSIQSMHLQMSQCQTGTA-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_nigroviridis_ENSTNIP00000017792 ------------------------------------------------------------ -------------------------------------------------------CAIMA -LRRLFLI--VFIYQVLPRSLSKEQLLLDMSASGSELGW--LT------TDDGWEIVQTV -VNSTLYYSYSVCNIDS-PEQDNWLRTTFIQRRPGISRVSVELRFVVRDCNTFDGA--SV ACKETFNLYISEADADVGTN----FRKGQFRKVATIAPDEVTH-----GRVLKVNTETRT VGPLSRRGFYLSF-QDMGACVAL-LSTRVYYKTCPSTVQSLAE---FPETVA-----DAL KEVEGACVENAISA-----TTP-RIYCSADGEWV-VPVGQCQCLAGYESTGDS--C---- ------------------------------------------------------------ ----------------------------QACKPGYFKASAESKFCQVCPDN--------T RPSEAGATQ---C----QCEEGFHRLPLRPPCIPLR--------CAPRDLSSSALS-AEG RLQLSWSPPLVTGGRRDLTYSVACAHCS-----EGQCVPCGEKIR-FEPGP-ADLQETRV VVTDLDAHLNY--------TFTVEAHSGVSQF--------SSGKAVASITTALDHT---- -----------G----------------------------SPKVT--------------- -FIHLD-DRSATSLTLSWTLS-RRAPAHTNQ-RYELMYRRK------------------- ------------DGDGERDVTTYTVLILEKNSVQIGDLTP---DTPYVVRVKVEGPEVNP GGHSVEQVFHTLPLA-ETQ---------I----------------QNKSTLVMG-GVFGI MVILL-VAVAVLL---LRRR---------------------------------------- -------------------------KINFWHRGGPEDPYFPA------------------ ------------------------------------DQLKPLKSYVDPHMYEDPNIAIQK FV-------------TEI-DPSAISKQKVIGVGEFGEVFRGVMKTRGQ-GEV--NVAIKT LKPGY--------SE--KQRLDFLS---EASIMGQ--FSHPNIIHLEGVVTKF-KHIMIV TEYMDNGALDTYL-KGRD-------GEIPPYQLVGMLRGIA--AGMQYLS---NM---SY VHRDLAARNILVNS--------NLECKVSDFGLSRVLED----D-DEGTY---------- --------TTR-GGKIPIRWTAPEAI-AYRK--FTSASDVWSFGIVMWEVMAFGERPYWD MS----NHE--VMKAINEA--------FR------------------------------- ------------------------LPAP----MDCPSA-IYQLML--QCWQHDRSKRPRF S---------------------------------------------D-IVSFLDKLLRSP E--------SLKTIADFDPRVSIRLPSTSGC-DGTLFRSVPEWLESIRMSQYSESFARAG ITSMEQVL---------------------------------------------------- --ALRHE----DIKNIGVRLPGHMKRIAYSILGLKDETSSLSVFSV-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >G_aculeatus_ENSGACP00000007049 ------------------------------------------------------------ -------------------------------------------------------MDFFT GFR-PLLFSYVLINGILITLQTKEEVLLDMKATGGELGW--LTWPLEQGDKPGWEVTQRT -LNGSQFYTYSVCNVGE-REQDNWLRTTFIQRHQSASRVFVELQFIVRDCNSFGGS--SL TCKETFNLFTSESDADVGTT----FRKGQFKKVATIAPDEITG-----KNELRINTETRV VENLSRKGFYLAF-QDIGACVAL-LSTRVYYKTCPATVKSLVL---FPETVAG-GENQGL REVSGACVDNAVSE-----ESP-RIYCTVDGDWA-VMVGQCQCKPGYEEVKEA--C---- ------------------------------------------------------------ ----------------------------QECRPGFFKAAASGDKCEPCPAN--------S EQLDSGALV---C----PCTDGFYRAPTDPPTGPCSGLP-----SAPRDLVATTVQLSTG KLLLSWSPPEDTAGRTDVTYSVECQRCE-----DSVCQLCGEKIR-FEPAG-TGLTDTKV SVSSLDAHLNY--------TFTVKAHSGVSMF--EAEPRSSRPPSSISLTVSLRYT---- -----------D----------------------------PPRIT--------------- -TLRMV-ERTSASLSLSWDVF-PRPRSQSQPIQYKLTYRKK------------------- --------------DDNLVATTIIVRILEKNFVHVVDLTP---CTAYMCKV-ALGSDGSP GGSSIEEQFETSP---EGPL--------T----------------QNNTAVIFA-AAIGG AAMLF-IVILVLF---LRRR---------------------------------------- -------------------------KRNSHSRQGPEDTYFSSS----------------- ------------------------------------EQLKPLKTYVDPHTYEDPNVAVLK FA-------------TEI-HPSHITKQKVIGAGEFGEVYRGNLKMPGR-KEV--AVAIKT LKPGY--------TE--KQRQDFLS---EASIMGQ--FSHQNIIRLEGVVTKF-KHAMIV TEYMENGALDRYL-KDHD-------GEFPSFQLVGMMYGIA--AGMKYLS---DM---SY VHRDLAARNILVNN--------NLECKVSDFGLSRVLED----D-PEGTY---------- --------TTS-GGKIPIRWTAPEAI-AYRK--FTSASDVWSFGIVMWEVMAFGERPYWD MS----NHE--VMKAINEA--------FR------------------------------- ------------------------LPAP----MDCPSA-VYQLML--QCWLQDRSKRPRF G---------------------------------------------D-IVNLLDKLLRSP D--------SLKTIADFDPRVSIRLPSTSGS-DGSPFRSVSEWLESIKMSQYSENFTCAG VVTMDHVL---------------------------------------------------- --QMKNE----DIKNIGVRLPGHLKRIAYSILGLKDQTSTLSVFAV-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >X_tropicalis_ENSXETP00000051995 ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------LFSSDEAFNKV-----------N LNYRTENGLSLLHLCCICGGNKSHIRTLMLKGLRP--------SRLTKNGFTALHMAAYK DN---------------------------AELLTALLHGG-ADIQQVGYGALTALHIATI AGNHEAVDILLQHGAFVNVQDAVFFTPLHIAAYYGHEQVTHLLLKFGADVNMSGEVGDRP LHL----ASAKGYL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NIT KLLLEEGTKAD-----VNAQDNEDHVPLHFCSRFGHHEIVKYLLQSNSDVQPHVV--NIY GDTPLHLACYNGKAEVVKELIQLSGTESLTKENIFSETAFHSACT-YGKNMELVKF---- ----------------------------------------LLDQNVLNINHQGRDGHTGL HCACYHGHIRLVQFLLDNGADMNLVA----------------CDPSRSSGE--------- -------------KDEQTCLMWAYEKGHDAIVTLLKHY-K---RPQDESPCNEYSQPGG- -DGSYVS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------VPSPLGKIKSMTKE KA-DVLLLRASLPSHFHL-QMSEIEFHEIIGSGSFGKVYKGRC------RNK--IVAIKR YRA---NTYC---SK--SDVDMFCR---EVSILCR--LNHPCVIQFVGACLDDPSQFAIV TQYISGGSLFSLL-HEQK-------RNLDLQSKLIIAVDVA--KGMEYLH----NLTYPI IHRDLNSHNILLYE--------DGHAVVADFGESRFLLS--------LDE----D----- --------NMT-KQPGNLRWMAPEVFSQCTR--YTIKADVFSYALCLWELLT-GEIPFAH LK----PAA--AAADMAYH------H-IR------------------------------- ------------------------PPIG----YSIPKP-ISSLLM--RGWNACPEGRPEF S---------------------------------------------E-VVSKLEECLSNI E-LMSPASSNSSGSLSPSASSDCLLGRGSPG-RSHVAALRTRFE-LEYALNSRAYSFWSQ RIYGSESA---------------------------------------------------- -RGLAFEEIRKSFQYPPIDKNGYVSDPMSTMRFHSCCRSS-SFEDSN------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >C_familiaris_ENSCAFP00000010420 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------CPAGMFKASQEAEGCSHCPSN--------S RSPSEASPI---C----TCRTGYYRADFDPPEVACTSVP-----SGPRNVISIV---NET SIILEWHPPRETGGRDDVTYNIICRKCRA---DRRSCSRCDDNVE-FVPRQ-LGLTECRV SISSLWAHTPY--------TFDIQAVNGVSG-------KSPFPPQHVSVNITTNQA---- -----------A----------------------------PSTVP--------------- -IMHQV-SATMRSITLSWPQP-EQPNGIIL--DYEIRYYEK------------------- ---------------EHNEFNS-SMARSQTNTARIDGLRP---GMVYVVQVRARTV-AGY GKFSGKMCFQTLTDAYDYKSE-------L----------------REQLPLIAG-SAAAG VVFVV-SLVAISIVC-SRKR---------------------------------------- -------------------------AYSKEAVYSDKLQHYSTGR---------------- -------------------------------------GSPGMKIYIDPFTYEDPNEAVRE FA-------------KEI-DVSFVKIEEVIGAGEFGEVYKGRLKLPGK-REI--YVAIKT LKAGY--------SE--KQRRDFLS---EASIMGQ--FDHPNIIRLEGVVTKS-RPVMII TEFMENGALDSFL-RQND-------GQFTVIQLVGMLRGIA--AGMKYLA---EM---NY VHRDLAARNILVNS--------NLVCKVSDFGLSRYLQD----DTSDPTY---------- --------TSSLGGKIPVRWTAPEAI-AYRK--FTSASDVWSYGIVMWEVMSFGERPYWD MS----NQD--VINAIEQD--------YR------------------------------- ------------------------LPPP----MDCPAA-LHQLML--DCWQKDRNSRPRF A---------------------------------------------E-IVNTLDKMIRNP A--------SLKTVATITAVPSQPLLDRSIP-DFTAFTTVDDWLSAIKMVQYRDSFLTAG FTSLQLVT---------------------------------------------------- --QMTSE----DLLRIGVTLAGHQKKILNSIHSMRVQMSQSPTTMA-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >M_mulatta_ENSMMUP00000028101 ------------------------------------------------------------ ------------------------------------------------------------ -----MALDCLLLLLLASAVAAMEETLMDTRTATAELGW--TANPASG-----WEEVSGY DENLNTIRTYQVCNVFE-PNQNNWLLTTFINRR-GAHRIYTEMRFTVRDCSSLPNV--PG SCKETFNLYYYETDSVIATKKSAFWSEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRS FGPLTRNGFYLAF-QDYGACMSL-LSVRVFFKKCPSIVQNFAV---FPETMTG-AESTSL VIARGTCIPNAEEV-----DVPIKLYCNGDGEWM-VPIGRCTCKPGYEP-ENSVAC---- ------------------------------------------------------------ ----------------------------KACPAGTFKASQEAEGCSHCPSN--------S RSPAEASPI---C----TCRTGYYRADFDPPEVACTSVP-----SGPRNVISIV---NET SIILEWHPPRETGGRDDVTYNIICKKCRA---DRRSCSRCDDNVE-FVPRQ-LGLTECRV SISSLWAHTPY--------TFDIQAINGVSS-------KSPFPPQHVSVNITTNQA---- -----------A----------------------------PSTVP--------------- -IMHQV-SATMRSITLSWPQP-EQPNGIIL--DYEIRYYEK------------------- ---------------EHNEFNS-SMARSQTNTARIDGLRP---GMVYVVQVRARTV-AGY GKFSGKMCFQTLTDD-DYKSE-------L----------------REQLPLIAG-SAAAG VVFVV-SLVAISIVC-SRKR---------------------------------------- -------------------------AYSKEAVYSDKLQHYSTGR---------------- -------------------------------------GSPGMKIYIDPFTYEDPNEAVRE FA-------------KEI-DVSFVKIEEVIGAGEFGEVYKGRLKLPGK-REI--YVAIKT LKAGY--------SE--KQRRDFLS---EASIMGQ--FDHPNIIRLEGVVTKS-RPVMII TEFMENGALDSFL-RQND-------GQFTVIQLVGMLRGIA--AGMKYLA---EM---NY VHRDLAARNILVNS--------NLVCKVSDFGLSRYLQD----DTSDPTY---------- --------TSSLGGKIPVRWTAPEAI-AYRK--FTSASDVWSYGIVMWEVMSFGERPYWD MS----NQD--VINAIEQD--------YR------------------------------- ------------------------LPPP----MDCPAA-LHQLML--DCWQKDRNSRPRF A---------------------------------------------E-IVNTLDKMIRNP A--------SLKTVATITAVPSQPLLDRSIP-DFTAFTTVDDWLSAIKMVQYRDSFLTAG FTSLQLVT---------------------------------------------------- --QMTSE----DLLRIGVTLAGHQKKILNSIHSMRVQMSQSPTAMA-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >P_pygmaeus_ENSPPYP00000015802 ----------------------------------------------------THTCTPTP TRARTAPRAHTPAHAHAALRGVLSGRERERIPRSHPRGAQRRPGTRRSPGAAASAWTRPG GRRPAMALDYLLLLLLASAVAAMEETLMDTRTATAELGW--TANPASG-----WEEVSGY DENLNTIRTYQVCNVFE-PNQNNWLLTTFINRR-GAHRIYIEMRFTVRDCSSLPNV--PG SCKETFNLYYYETDSVIATKKSAFWSEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRS FGPLTRNGFYLAF-QDYGACMSL-LSVRVFFKKCPSIVQNFAV---FPETMTG-AESTSL VIARGTCIPNAEEV-----DVPIKLYCNGDGEWM-VPIGRCTCKPGYEP-ENSVAC---- ------------------------------------------------------------ ----------------------------KACPAGTFKASQEAEGCSHCPSN--------S RSPAEASPI---C----TCRTGYYRADFDPPEVACTSVP-----SGPRNVISIV---NET SIILEWHPPRETGGRDDVTYNIICKKCRA---DRRSCSRCDDNVE-FVPRQ-LGLTECRV SISSLWAHTPY--------TFDIQAINGVSS-------KSPFPPQHVSVNITTNQA---- -----------A----------------------------PSTVP--------------- -IMHQV-SATMRSITLSWPQP-EQPNGIIL--DYEIRYYEK------------------- ---------------EHNEFNS-SMARSQTNTARIDGLRP---GMVYVVQVRARTV-AGY GKFSGKMCFQTLTDD-DYKSE-------L----------------REQLPLIAG-SAAAG VVFVV-SLVAISIVC-SRKR---------------------------------------- -------------------------AYSKEAVYSDKLQHYSTGR---------------- -------------------------------------GSPGMKIYIDPFTYEDPNEAVRE FA-------------KEI-DVSFVKIEEVIGAGEFGEVYKGRLKLPGK-REI--YVAIKT LKAGY--------SE--KQRRDFLS---EASIMGQ--FDHPNIIRLEGVVTKS-RPVMII TEFMENGALDSFL-RQND-------GQFTVIQLVGMLRGIA--AGMKYLA---EM---NY VHRDLAARNILVNS--------NLVCKVSDFGLSRYLQD----DTSDPTY---------- --------TSSLGGKIPVRWTAPEAI-AYRK--FTSASDVWSYGIVMWEVMSFGERPYWD MS----NQD--VINAIEQD--------YR------------------------------- ------------------------LPPP----MDCPAA-LHQLML--DCWQKDRNSRPRF A---------------------------------------------E-IVNTLDKMIRNP A--------SLKTVATITAVPSQPLLDRSIP-DFTAFTTVDDWLSAIKMVQYRDSFLTAG FTSLQLVT---------------------------------------------------- --QMTSE----DLLRIGITLAGHQKKILNSIHSMRVQMSQSPTAMA-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >E_caballus_ENSECAP00000011695 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MFKANQEAEGCSHCPSN--------S RSPSEASPI---C----TCRTGYYRADFDPPEVACTSVP-----SGPRNVISIV---NET SIILEWHPPRETGGRDDVTYNIICKKCRA---DRRSCSRCDDNVE-FVPRQ-LGLTECRV SISSLWAHTPY--------TFDIQAVNGVSS-------KSPFPPQHVSVNITTNQA---- -----------A----------------------------PSTVP--------------- -IMHQV-SATMRSITLSWPQP-EQPNGIIL--DYEIRYYEK------------------- ---------------EHNEFNS-SMARSQTNTARIDGLRP---GMVYVVQVRARTV-AGY GKFSGKMCFQTLTDD-DYKSE-------L----------------REQLPLIAG-SAAAG VVFVV-SLVAISIVC-SRKR---------------------------------------- -------------------------AYSKEAVYSDKLQHYSTGR---------------- -------------------------------------GSPGMKIYIDPFTYEDPNEAVRE FA-------------KEI-DVSFVKIEEVIGAGEFGEVYKGRLKLPGK-REI--YVAIKT LKAGY--------SE--KQRRDFLS---EASIMGQ--FDHPNIIRLEGVVTKS-RPVMII AEFMENGALDSFL-RQND-------GQFTVIQLVGMLRGIA--AGMKYLA---EM---NY VHRDLAARNILVNS--------NLVCKVSDFGLSRYLQD----DTSDPTY---------- --------TSSLGGKIPVRWTAPEAI-AYRK--FTSASDVWSYGIVMWEVMSFGERPYWD MS----NQD--VINAIEQD--------YR------------------------------- ------------------------LPPP----MDCPAA-LHQLML--DCWQKDRNSRPRF A---------------------------------------------E-IVNTLDKMIRNP A--------SLKTVATITAVPSQPLLDRSIP-DFTAFTTVDDWLSAIKMVQYRDSFLTAG FTSLQLVT---------------------------------------------------- --QMTSE----DLLRIGVTLAGHQKKILNSIHSMRVQMNQSPTAMA-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >H_sapiens_ENSP00000381097 ----------------------------------------------------THTCTPTP TRARTAPRAHTPAHAHAALREVRSGRERERIPRSHPRRAQRRPGTRRSPGAAASAWSRPA GRRPAMALDYLLLLLLASAVAAMEETLMDTRTATAELGW--TANPASG-----WEEVSGY DENLNTIRTYQVCNVFE-PNQNNWLLTTFINRR-GAHRIYTEMRFTVRDCSSLPNV--PG SCKETFNLYYYETDSVIATKKSAFWSEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRS FGPLTRNGFYLAF-QDYGACMSL-LSVRVFFKKCPSIVQNFAV---FPETMTG-AESTSL VIARGTCIPNAEEV-----DVPIKLYCNGDGEWM-VPIGRCTCKPGYEP-ENSVAC---- ------------------------------------------------------------ ----------------------------KACPAGTFKASQEAEGCSHCPSN--------S RSPAEASPI---C----TCRTGYYRADFDPPEVACTSVP-----SGPRNVISIV---NET SIILEWHPPRETGGRDDVTYNIICKKCRA---DRRSCSRCDDNVE-FVPRQ-LGLTECRV SISSLWAHTPY--------TFDIQAINGVSS-------KSPFPPQHVSVNITTNQA---- -----------A----------------------------PSTVP--------------- -IMHQV-SATMRSITLSWPQP-EQPNGIIL--DYEIRYYEK------------------- ---------------EHNEFNS-SMARSQTNTARIDGLRP---GMVYVVQVRARTV-AGY GKFSGKMCFQTLTDD-DYKSE-------L----------------REQLPLIAG-SAAAG VVFVV-SLVAISIVC-SRKR---------------------------------------- -------------------------AYSKEAVYSDKLQHYSTGR---------------- -------------------------------------GSPGMKIYIDPFTYEDPNEAVRE FA-------------KEI-DVSFVKIEEVIGAGEFGEVYKGRLKLPGK-REI--YVAIKT LKAGY--------SE--KQRRDFLS---EASIMGQ--FDHPNIIRLEGVVTKS-RPVMII TEFMENGALDSFL-RQND-------GQFTVIQLVGMLRGIA--AGMKYLA---EM---NY VHRDLAARNILVNS--------NLVCKVSDFGLSRYLQD----DTSDPTY---------- --------TSSLGGKIPVRWTAPEAI-AYRK--FTSASDVWSYGIVMWEVMSFGERPYWD MS----NQD--VINAIEQD--------YR------------------------------- ------------------------LPPP----MDCPAA-LHQLML--DCWQKDRNSRPRF A---------------------------------------------E-IVNTLDKMIRNP A--------SLKTVATITAVPSQPLLDRSIP-DFTAFTTVDDWLSAIKMVQYRDSFLTAG FTSLQLVT---------------------------------------------------- --QMTSE----DLLRIGITLAGHQKKILNSIHSMRVQISQSPTAMA-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >P_troglodytes_ENSPTRP00000056656 ----------------------------------------------------THTCTPTP TRARTAPRAHTPAHAHAALREVRSGRERERIPRSHPRRAQRRPGTRRSPGAAASAWSRPG GRRPAMALDYLLLLLLASAVAAMEETLMDTRTATAELGW--TANPASG-----WEEVSGY DENLNTIRTYQVCNVFE-PNQNNWLLTTFINRR-GAHRIYTEMRFTVRDCSSLPNV--PG SCKETFNLYYYETDSVIATKKSAFWSEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRS FGPLTRNGFYLAF-QDYGACMSL-LSVRVFFKKCPSIVQNFAV---FPETMTG-AESTSL VIARGTCIPNAEEV-----DVPIKLYCNGDGEWM-VPIGRCTCKPGYEP-ENSVAC---- ------------------------------------------------------------ ----------------------------KACPAGTFKASQEAEGCSHCPSN--------S RSPAEASPI---C----TCRTGYYRADFDPPEVACTSVP-----SGPRNVISIV---NET SIILEWHPPRETGGRDDVTYNIICKKCRA---DRRSCSRCDDNVE-FVPRQ-LGLTECRV SISSLWAHTPY--------TFDIQAINGVSS-------KSPFPPQHVSVNITTNQA---- -----------A----------------------------PSTVP--------------- -IMHQV-SATMRSITLSWPQP-EQPNGIIL--DYEIRYYEK------------------- ---------------EHNEFNS-SMARSQTNTARIDGLRP---GMVYVVQVRARTV-AGY GKFSGKMCFQTLTDD-DYKSE-------L----------------REQLPLIAG-SAAAG VVFVV-SLVAISIVC-SRKR---------------------------------------- -------------------------AYSKEAVYSDKLQHYSTGR---------------- -------------------------------------GSPGMKIYIDPFTYEDPNEAVRE FA-------------KEI-DVSFVKIEEVIGAGEFGEVYKGRLKLPGK-REI--YVAIKT LKAGY--------SE--KQRRDFLS---EASIMGQ--FDHPNIIRLEGVVTKS-RPVMII TEFMENGALDSFL-RQND-------GQFTVIQLVGMLRGIA--AGMKYLA---EM---NY VHRDLAARNILVNS--------NLVCKVSDFGLSRYLQD----DTSDPTY---------- --------TSSLGGKIPVRWTAPEAI-AYRK--FTSASDVWSYGIVMWEVMSFGERPYWD MS----NQD--VINAIEQD--------YR------------------------------- ------------------------LPPP----MDCPAA-LHQLML--DCWQKDRNSRPRF A---------------------------------------------E-IVNTLDKMIRNP A--------SLKTVATITAVPSQPLLDRSIP-DFTAFTTVDDWLSAIKMVQYRDSFLTAG FTSLQLVT---------------------------------------------------- --QMTSE----DLLRIGITLAGHQKKILNSIHSMRVQMSQSPTAMA-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >M_musculus_ENSMUSP00000088334 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MSSLGAS FV--------------QI-KFDDLQFFENCGGGSFGSVYRAKWI----SQDK--EVAVKK LLK-------------------IEK---EAEILSV--LSHRNIIQFYGVILEP-PNYGIV TEYASLGSLYDYI-NSNR------SEEMDMEHIMTWATDVA--KGMHYLH---MEAPVKV IHRDLKSRNVVIAA--------DGVLKICDFGASRFHNH--------TTH---------- ---------MS-L-VGTFPWMAPEVI-QSLP--VSETCDTYSYGVVLWEMLT-REVPFKG LE----GLQ--VAWLVVEK------N-ER------------------------------- ------------------------LTIP----SSCPRS-FAELLH--QCWEADAKKRPSF K---------------------------------------------Q-IISILESMSNDT N-LPDQCNSFLHNKAEWRCEIEATLERLKKL-ERDLSFKEQELKERERRLKMWEQKLTEQ SNTPLLP-----------------------SFEIGAWTE-DDVYFWVQQLVRKG---ESS VEMSGYASLFKEN-----NITGKRLLLLEEE----DLKDMGIVSKGHIIHFKSAIEKLTH DYLNLFHFPPLIKDSGGEPEENEEKIVNLELVFG-FHLKPGTGPQDCKWKMYMEMDGDEV AITYIKDVTFNTSLPDAEILKMTKPPFVMEKWIVGIAEDQTVECTVTYENDVRTPKLTKH VHSIQWDRTKPQDEVKAVQLAIQTLFSSSEGNPGSRSDSSADCQWLDTL------RMRQI ASH-TSLQ------RSQSNPI-LGSPFFPYFANQD-SYAAAVRRTQTPVKYQQITPSINP SRSSSPTQYGLSRNFSSLNL-SSRDSGFSSLN-DSSSE--RGRYSDRSRNKYYRGSVSLN SSPKGRYGGKSQHSTPSRERYSGKFYRLPQSALNTHQSPDFKRSPNDHDRRVPRTIPGMP LHP---ETASKAGEEESRVSEGGWTKVEYRK--KTHRQ-LSAKTSKERTRGNYRGRRNF- --------------------------------------------------- >G_aculeatus_ENSGACP00000013602 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------WYY--------------------------------------------GNI NRV--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KAE KLLLASQNK-------------------------------------------DGSFLVRI SESHSDEYTVSARSEGKVYHFRVQRSTIGAYFVSDKISFSTLGELISYYQ---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KNHRSLGVLLDEPCAQQIFQPIIS EP-------------WER-PREEFRLHKKLGEGHFGEVWEALWTT----ENK--KVAIKT LKQ----------AD--TKQDEFVK---EVQALKS--LHHPKLIQLLAMCSRG-EPVYIV TELMRKGSLKSYL-ASAE------GLMLTSAHLIYMGSQIA--EGMAYLE---DR---NI VHRDLAARNILVGD--------DLVCKVADFGLARIIKD--------SVY---------- --------TASRNTKIPVRWTAPEAA-IHQK--FSVKSDVWSFGVLLYEMMSRGKMPYEG KN----NKE--VLDLLSSG--------FR------------------------------- ------------------------LPCP----TRCPQN-IYRIMM--DCWAAEPSKRPSF H---------------------------------------------A-LHSQLDSIYTRI YFKTV------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >R_norvegicus_ENSRNOP00000002067 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MSSLGAS FV--------------QI-KFDDLQFFENCGGGSFGSVYRAKWI----SQDK--EVAVKK LLK-------------------IEK---EAEILSV--LSHRNVIQFYGVILEP-PNYGIV TEYASLGSLYDYI-NSNR------SEEMDMEHIMTWATDVA--KGMHYLH---MEAPVKV IHRDLKSRNVVIAA--------DGVLKICDFGASRFHNH--------TTH---------- ---------MS-L-VGTFPWMAPEVI-QSLP--VSETCDTYSYGVVLWEMLT-REVPFKG LE----GLQ--VAWLVVEK------N-ER------------------------------- ------------------------LTIP----SSCPRS-FAELLH--QCWEADAKKRPSF K---------------------------------------------Q-IISILESMSNDT N-LPDQCNSFLHNKAEWRCEIEATLERLKKL-ERDLSFKEQELKERERRLKMWEQKLTEQ SNTPLLP-----------------------SFEIGAWTE--DVYFWVQQLVGKG---NSL FEMSGYASLFKEN-----NITGKRLLLLEEE----DLKDMGIVSKGHIIHFKSAIEKLTH DYLNLFHFPPLIKDSGEEPEENEEKIVNLELVFG-FHLKPGTGPQDCKWKMYMEMDGDEV AIAYIKDVTFNTSLPDAEILKMTKPPFVMEKWIVGIVKDQTVECTVTYESDVRTPKFTKH VHSIQWDRAKPQDEVKAVQLAIQTLFSSSEGNPGSRSDSSADCQWLDTL------RMRQI ASH-SSLQ------RSQSNPI-LGSPFFQYFVNQD-SYAAAVRRTQTPVKYQQITPSINP SRSSSPTQYGLTKNFSSLHL-NSRDSGFSSLN-DSSSE--RGRYSDRSRNKYYRGSVSLN SSPKGRYGGKSQHSTPSRERYPGKFYRLPQSALNTHQSPDFKRSPNDHDRRAPKTIPGMP LHP---ETAPKAGEEESRVSEGGWTKVEYRK--KTHRQ-LSAKTSKDRTRGNYRGRRNF- --------------------------------------------------- >T_rubripes_ENSTRUP00000037331 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------PEGGRGDGFPG HF---------------------------------------------------------- -GNFAKDEFEADW----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------TKMAECRFSQVYEVKL------KAWQEKCVLKC FH----PPVC---SK--SSYRKIIN---EVSKIAK--VKFKYIVAIYGVCSEA---TAVV MEHMSNGSLNNLL-ASHT---------LMWPKKFQMVHEIS--MGVNFLH---SMNP-PI LHLNLKTSNILLDD--------HLHAKISDFALIHWEEG--------MSK--TLFM---- --------ESL-TARGNISYIPPETF-TQSSDPPGTASDVYSFGIIIWEILT-QQKPYAA QS----AMR--HLVFQVSQGRRPCLEIIP------------------------------- ------------------------EWRP----NECDR--IICMMK--QCWDQEPRKRPQF S---------------------------------------------D-IVKTTESLCEVL K-IPGSIQCHMSGEERQRSNYPWLDSPINQN-QIISELQIASVFRTEKESSRSSQMSPLQ FSSIVISRKMCSLQNLHAILGIWDILLHALSFPLHSADEKLEKDNILSFLSRKDFGSFRQ SLKQEHVHTVYTGKNSLLHYTVTSKDAASVEHVLNLGADINATTAQGYTPLIVAVLHRLH DIISLLLEHGAVVGHGDEDQWTALHFAAQNGDDRTVRLLLDKGAVVDARERAGWMPLHLA CQNGHEPVVRLLLSRMSEEAVGEREGHGRTPLHMASAYGHLSIAKLLLSQGADPNATDGS LSTPLHLSAEEGHNRVVRQLLKSGVATDSANSQGYNPLHLAALKGHTGICRQLLSNGANP DCTTLQAWTPMHLAALKGNEAIVVQLVCNGGSTNAKSENGWTPLHLACHQSEPEVTSVLL EAAADPNATEASKGWSPLHFACNSVSFQCVLHLIAHHADVNALS---------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >R_norvegicus_ENSRNOP00000028185 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MEPLKNLFLKSPLGSWNGSGS GG---------------------------GGGSGGVRPEGSPKATAAYANPV--WTALFD YEPNGQDELALRK--------------------------------------------GDR VEV----LSRDAAI---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SGD EGWWAGQ-VGGQVGIFPSNYVS-R------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GGG----------- ---PPP---------CEVASFQELRLEEVIGIGGFGKVYRGSW------RGE--LVAVKA ARQD--PDED---IS--VTAESVRQ---EARLFAM--LAHPNIIALKAVCLEE-PNLCLV MEYAAGGPLSRAL-AGRR---------VPPHVLVNWAVQIA--RGMHYLH---CEALVPV IHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHK--------TTQ---------- ---------MS-A-AGTYAWMAPEVI-KAST--FSKGSDVWSFGVLLWELLT-GEVPYRG ID----CLA--VAYGVAVN------K-LT------------------------------- ------------------------LPIP----STCPEP-FAQLMA--DCWAQDPHRRPDF A---------------------------------------------S-ILQQLEALEAQV L-REMPRDSFHSMQEGWKREIQGLFDELRAK-EKELLSREEELTRAAREQRSQAEQLRRR EHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRA--RDGGERISMPLDFK HRITVQASPGLDRRRNVFEVGA---GDSPTFPRFRAIQLEPAESGQTWGRQS---PRRLD DSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEA---------------TWYLDSDDSS PLGSPSTPPALNGNPPR-P--SPEPEEPRRSG---------------------------- ----------PTERGNSSGTPKLIQRALLRGTALLASLGLGRDLQPPG------------ -----GLSRERGESPTAPPPAQ---MASPCPPDLPSTPLIHLSQATPDARGPLTP----- -------APLLLDLGVS-SGQPSAKSPRREET-RGR------------------------ -------------------------------------TVSPPPGISRSAPGTPGTPRSPP LGLIT------------------------------------------------------- -------------------ANPFRGGSQDCRTQTKDVG--AQAPWAPEAGP >H_sapiens_ENSP00000387259 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MSSLGAS FV--------------QI-KFDDLQFFENCGGGSFGSVYRAKWI----SQDK--EVAVKK LLK-------------------IEK---EAEILSV--LSHRNIIQFYGVILEP-PNYGIV TEYASLGSLYDYI-NSNR------SEEMDMDHIMTWATDVA--KGMHYLH---MEAPVKV IHRDLKSRNVVIAA--------DGVLKICDFGASRFHNH--------TTH---------- ---------MS-L-VGTFPWMAPEVI-QSLP--VSETCDTYSYGVVLWEMLT-REVPFKG LE----GLQ--VAWLVVEK------N-ER------------------------------- ------------------------LTIP----SSCPRS-FAELLH--QCWEADAKKRPSF K---------------------------------------------Q-IISILESMSNDT S-LPDKCNSFLHNKAEWRCEIEATLERLKKL-ERDLSFKEQELKERERRLKMWEQKLTEQ SNTPLLP-----------------------SFEIGAWTE-DDVYCWVQQLVRKG---NSS AEMSVYASLFKEN-----NITGKRLLLLEEE----DLKDMGIVSKGHIIHFKSAIEKLTH DYINLFHFPPLIKDSGGEPEENEEKIVNLELVFG-FHLKPGTGPQDCKWKMYMEMDGDEI AITYIKDVTFNTNLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKH VHSIQWSRTKPQDEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTL------RMRQI ASN-TSLQ------RSQSNPI-LGSPFFSHFDGQD-SYAAAVRRPQVPIKYQQITP-VNQ SRSSSPTQYGLTKNFSSLHL-NSRDSGFSSGNTDTSSE--RGRYSDRSRNKYGRGSISLN SSPRGRYSGKSQHSTPSRGRYPGKFYRVSQSALNPHQSPDFKRSPR--DLHQPNTIPGMP LHP---ETDSRASEEDSKVSEGGWTKVEYRK--KPHRP-SPAKTNKERARGDHRGWRNF- --------------------------------------------------- >E_caballus_ENSECAP00000000450 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MSSLGTS FV--------------QI-KFDDLQFFENCGGGSFGSVYRAKWI----SQDK--EVAVKK LLK-------------------IEK---EAEILSV--LSHRNIIQFYGVILEP-PNYGIV TEYASLGSLYDYI-NSNR------SEEMDMDHIMTWATDVA--KGMHYLH---MEAPVKV IHRDLKSRNVVIAA--------DGVLKICDFGASRFHNH--------TTH---------- ---------MS-L-VGTFPWMAPEVI-QSLP--VSETCDTYSYGVVLWEMLT-REVPFKG LE----GLQ--VAWLVVEK------N-ER------------------------------- ------------------------LTIP----SSCPRS-FAELLR--QCWEADAKKRPSF K---------------------------------------------Q-IISILESMSNDT K-LSDQCNSFLHNKAEWRCEIEATLERLKKL-ERDLSFKEQELKERERRLKMWEQKLTEQ SNTPLLP-----------------------SFEIGSWTE-DDVYFWVQQLVRKGK--DSS AEMSVYASLFKEN-----NITGKRLLLLEEE----DLKDMGIVSKGHIIHLKLAIEKLTY DYLNLFHFPPLIKDSGGEPEENEEKIVNLELVFG-FHLKPGTGPQDCKWKMYMEMDGDEI AITYIKDVTFNTNLPDAEMLKMTKPPFVMERWIVGIMEDQTVECTVTYESDVRAPKSTKH VHSIQWSRTKPQDEVKAVQLAIQTLFLNSEGNPRSRSDSSADCQWLDTL------RMRQI ASN-TSLQ------RSQSNPI-LGSQFFPYFNDQD-SYAAAVRRTPVPIKYQQITP-INQ SRSSSPTQYGLTKNFSSLHL-NSRDSGFSSLTTDNSSE--RGRYSGRNRDKYGRGSVSLN SSPRGRYSGKSQHSAPSRERYSGKFYRVSQSALNSYQSPDFKRSPN--DRHQPRTIPGMP LHT---DTNSRASEEESKGSEGGWTKVEYRK--KPHRP-SPAKTNRERARGNYRGRRTV- --------------------------------------------------- >M_mulatta_ENSMMUP00000013728 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MSSLGAS FV--------------QI-KFDDLQFFENCGGGSFGSVYRAKWI----SQDK--EVAVKK LLK-------------------IEK---EAEILSV--LSHRNIIQFYGVILEP-PNYGIV TEYASLGSLYDYI-NSNR------SEEMDMDHIMTWATDVA--KGMHYLH---MEAPVKV IHRDLKSRNVVIAA--------DGVLKICDFGASRFHNH--------TTH---------- ---------MS-L-VGTFPWMAPEVI-QSLP--VSETCDTYSYGVVLWEMLT-REVPFKG LE----GLQ--VAWLVVEK------N-ER------------------------------- ------------------------LTIP----SSCPRS-FAELLH--QCWEADAKKRPSF K---------------------------------------------Q-IISILESMSNDT S-LPDKCNSFLHNKAEWRCEIEATLERLKKL-ERDLSFKEQELKERERRLKMWEQKLTEQ SNTPLLP-----------------------SFEIGAWTE-DDVYCWVQQLVRKGK--DSS AEMSVYASLFKEN-----NITGKRLLLLEEE----DLKDMGIVSKGHIIHFKSAIEKLTH DYINLFHFPPLIKDSGGEPEENEEKLVNLELVFG-FHLKPGTGPQDCKWKMYMEMDGDEI AITYIKDVTFNTNLPDAEILKMTKPPFVMEKWIVGIAKNQTVECTVTYESDVRTPKSTKH VHSIQWSKTKPQDEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTL------RMRQI ASN-TSLQ------RSQSNPI-LGSPFFSYLDGQD-SYAAAVRRTQVPIKYQQITP-VNQ SRSSSPTQYGLTKNFSSLHL-SSRDSGFSSGNTDTSSE--RGRYSDRSRNKYGRGSISLN SSPRGRYSGKSQHSTPSRGRYPGKFYRVSQSPLNPHQSPDFKRSPR--DLHQPNTIPGMP LHP---ETDSRASEEESKVSEGGWTKVEYRK--KPHRP-SPAKTNKERARGDHRGWRNF- --------------------------------------------------- >T_nigroviridis_ENSTNIP00000008535 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------VDADC ISPSVKNSIHVG---------------------------------------------DRI LEINGTPVHNLPLD---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SLI LSLQETSQGLQLTIEHDPYGQGQEGGSSGPDHQREGRLSSPVSDSPNPAL---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------PVTQPPNPDIS---SLQTCIKAHRYSIDKSP SS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------SQKDISRSESLHVVSNRTHR IF-----------------QPSDLIHGEVLGKGCFGQAIKVTHR----ETGE--VMVMKE LICF---------DE--ETQKSFQT---EVKVLRC--LDHPNVLKFIGVLYKD-KRLNLV TEYIKGGTLGEII-KKMD-------SNFPWNLRVSFATDIA--AGMAYVH------SMNI IHRDLNSFNCLVQE--------DNTVVVADFGLSRFMVH--------DAHEEMLSVGTVS GLKKHDRRKRY-TVVGNPYWMAPEMI-NGKV--YDEKVDIFSFGIVLCEIIG-RVNADPD YL----PRA--MDYGLDVS------GFLE------------------------------- ------------------------HYCP----PDCPPA-FFPIAA--LCCDLDADKRPGF S---------------------------------------------T-LKEWLENLRMHL E------------------MGLALVSELDQL-QKDFWKKHGNLHSKNGLHAHGAASA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >M_domestica_ENSMODP00000011395 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MSSLGAS FV--------------QI-KFDDLQFFENCGGGSFGSVYRARWI----SQDK--EVAVKK LLK-------------------IEK---EAEILSV--LSHRNIIQFYGVILEP-PNYGIV TEYASLGSLYDYI-NSNR------SEEMDMEHIMTWATDVA--KGMHYLH---MEAPVKV IHRDLKSRNVVIAA--------DGVLKICDFGASRFHNH--------TTH---------- ---------MS-L-VGTFPWMAPEVI-QSLP--VSETCDTYSYGVVLWEMLT-REVPFKG LE----GLQ--VAWLVVEK------N-ER------------------------------- ------------------------LTIP----SSCPRS-FAELLH--QCWEADAKKRPSF K---------------------------------------------Q-IISILESMSNDT N-LPDQCNSFLHNKAEWRCEIEATLERLKKL-ERDLSFKEQELKERERRLKMWEQKLTEQ SNTPLLP-----------------------SFEISAWTE-EDVYFWMQQLTRKGKWSDSS EEMSIYATLFKEN-----NITGKRLLLLDEE----DLKDMGIISKGHIIHIKSAIEKLTN DYLNLFHFPPLMKDSGGELEENEEKVVNLELVFG-FHLKPGTGPQDCKWKMYMEMDGDEI AITYIKDVTFNTNLPDVETLKMTKPPFVMEKWIVGILPNQTVEYIVTYESDVRSPKSSKH IHSIQWSKTKPEDEVKAVRLVIQTLLVNSEGNAGSRSNSNTDCQWLNTL------RMRQI ASNPSSFQ------RSQSNPITAGSQFLPFLHNQT-SYAAAVQRTQAPIKYYQITP-INH SRSSSPTQYGLTKNFSSLHL-NSRDSGISSINSDTSSD--RGQYSGRSRNKSNRGSVSLN SSPKGRYSGKSQHSAPSAERYSGKFFRVSQSVLSPHQSLDSRKSPN--NLHQPRTIPGMP VNTGDTANDSKANEDESKVNEGGWTKVEYRK--KPHRP-VPVKTNKERARGAYRGRRNF- --------------------------------------------------- >T_nigroviridis_ENSTNIP00000013836 ------------------------------------------------------------ -------------------------------------------------------CVLLN DLNIPLLL--MLINGILITAQAKEEVLLDMNAIGGELGW--LTWSLDQVDKPGWEVVQKT -LNGSQLYTYSVC-VDE-REQDNWLRTTFIQRRPSASRVFVELKFIVRDCNFFDSS--SL TCKETFNLFTSESDADVGTT----FRKGQFRKVATIAPDEIS------KTDLRINTDTRV VENLSRKGFYLAF-QDIGACIALSIRSRVYYRK-PALAHCLAVLASFPETVAGWCRDQAL REVNGVCVENSISE-----ELP-RMHCTVDGDWV-VPVGQCQCKPGYEEVKDS--C---- ------------------------------------------------------------ ----------------------------QECQMGFFKGEASGEKCKPCPAN--------T QRLNSGALF---C----PCMDGFYRAPTDPLTGPCSGLP-----SAPRDLKATT---NAG KLHLSWSPPADTGGRTDITYKIECQRCE-----GTVCQSCGEKIH-YEPAS-VGLTDTKV LVSDLDAHLNY--------TFTVEAQSGISLFISQAPQQVKRPVSTSALTTSLLYT---- -----------D----------------------------PPKIT--------------- -TMRLV-AKTSTSLSLSWDVS-PRPRAHSPPIRYELTYRKK------------------- --------------DDNLDVTTYTVLILEKNSVQIFELAP---GTAYLFRVLALSIDNSP GGSSMEEQFETSA---EES---------S----------------PNKTAVILG-AAVGG AAMLL-IVVVVLL---LHRR---------------------------------------- -------------------------KRNPHIRQGPEDTYFSSSD---------------- -----------PT-----------------------EQLKPLKTYVDPHTYEDPNTAVMK FA-------------TEI-HPSHIAKEKVIGAGEFGEVYRGILKVPGR-KES--AVAIKT LKPGY--------TE--KQRQDFLS---EASIMGQ--FAHQNIIRLEGVVTKF-KHAMII TEYMENGALDRYL-RDHD-------GEFTSFQLVGMLRGIA--AGMKYLS---DM---SY VHRDLAARNILVNN--------TLECKVSDFGLSRVLED----D-PEGTY---------- --------TTS-GGKIPIRWTAPEAI-AYRK--FASASDVWSFGIVMWEVMAFGERPYWD MS----NHE--VMKAINEA--------FR------------------------------- ------------------------LPAP----MDCPSA-VYQLML--QCWLHDRAKRPRF G---------------------------------------------D-IVNLLDKLLRSP D--------SLKTIADFDPRVSIRLPSTSGS-DGSPFRSVSEWLESIKMSQYSENFSRAG VVTMDQVL---------------------------------------------------- --QMKNE----DIKNIGVRLPGHLKRIAYSILGLKDQTSTLSVFA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >A_carolinensis_ENSACAP00000000985 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------PL--WTVLYD YEATGEDELSLRR--------------------------------------------GEV VEV----LSKDAAV---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SGD DGWWAGK-IRHRLGIFPANYVTYQ------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------PGRYHHP----QFG LLEK-PGHQAQSQVMTEI-DFQHLELQEIIGVGGFGKVYRATW------KGQ--EVAVKA ARQD--PDED---IM--ATAANVRQ---EAKLFSM--LRHPNIIELRGVSLQE-PNLCLV MEFARGGPLNRVFHRGRR---------IPPHILVNWAVQIA--RGMQYLH---QEAIVSI LHRDLKSSNILLLEKIENDDIGNKTLKITDFGLAREWHR--------TTK---------- ---------MS-A-AGTYAWMAPEVI-KSSM--FSKGSDIWSYGVLLWELLT-GEVPYRG ID----GLA--VAYGVAVN------K-LT------------------------------- ------------------------LPIP----STCPEP-FAKLMK--DCWAQDPHIRPSF T---------------------------------------------L-ILEQLTAIEGAV M-TEMPQESFHSMQEDWKLEIQQIFDELRTK-EKELRSREEELTRAALHQKSQEELLKRR EQQLAEREIDVLERELNILIFQLNQDKPNVKKRKGKFKKSRLKL--KD-GHRISLPSDFQ HKITVQASPNLDKRRSLNSNSSSPPSSPPIIPRLRAIQLTSDESNRTWGRSTACHQEEFE DVKRSFKKKGCTWGPNSVQAKE-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_nigroviridis_ENSTNIP00000007192 ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LSQVAGEQKYHPECFTCLNCRTFIGDGDT YALVERSKLYCGHCYYQTVLTPES-----LPNSPSSQIPHTVTLVSIPGLDDGNEEGKSR GF---------------------------SVAIDQPIGPAGRLSPENTHTLRVSQVDADC ISPSVKNSIHVG---------------------------------------------DRI LEINGTPVHNLPLD---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------EID SLIQETSQRLQLTIEHDPYGQGQEGGSSGPDHQVDGRLSSPVSDSPNPAL---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------PVTQPPNPDIS---SLRTCIKARSYSIDKSP SS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------SQKDISRSES-RVVSKRTHR IF-----------------RPSDLIHGEVLGKGCFGQAIKVTHR----ETGE--VMVMKE LIRF---------DE--DTQKAFQK---EVKVLRC--LDHPNVLKFIGVLYKD-KRLNFI TEYIKGGTLGEII-KKMD-------SNFPWNLRVSFATDIA--AGMAYLH------SMNI IHRDLNSFNCLVQE--------DNTVVVADFGLSRFMVH--------DAHEEMLSVGTVS GLKKHDRRKRY-TVVGNPYWMAPEMI-NGKV--YDEKVDIFSFGIVLCEIIG-RVNADPD YL----PRA--MDYGLDVS------GFLE------------------------------- ------------------------HYCP----PDCPPA-FFPIAA--LCCDLDADKRPGF S---------------------------------------------T-LKEWLENLRMHL E------------------MGLALVSELDQL-QKDFWKKHGNLHSKNGLHAHGAASA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_nigroviridis_ENSTNIP00000007265 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MKVYIDPFTYEDPNEAVRE FA-------------KEI-EASFVKIEEVIGAGEFGEVCRGRLRVPGR-KEN--YVAIKT LKGGY--------TE--KQRRDFLS---EASIMGQ--FQHPNIIHLEGVITTS-CPVMIL TEFMENGALDSFL-RMND-------GQFTPIQLVGMLRGIA--AGMKYLS---DM---SF VHRDLAARNILVNS--------NLVCKVSDFGLSRFLTE----SSSDPTY---------- --------TSSLGGKIPIRWTAPEAI-AYRK--FTSASDVWSYGIVMWEVMSYGERPYWD MS----NQD--VGGRDRCD--------YR------------------------------- ------------------------LPPP----PDCPAS-LHALML--DCWQKERANRPRF S---------------------------------------------E-V----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >B_taurus_ENSBTAP00000005378 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MEPLKNLFLKSPLGSWNSSGS GG---------------------------GGGGGGGWPEGSPKA-AAYANPV--WTALFD YEPSGQDELALRK--------------------------------------------GDR VEV----LSRDAAI---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SGD EGWWAGQ-VGGQVGIFPSNYVS-R------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GGG----------- ---PPP---------CEMASFQELRLEEVIGIGGFGKVYRGSW------RGE--LVAVKA ARQD--PDED---IS--VTTESVRQ---EARLFAM--LAHPNIIALKAVCLEE-PNLCLV MEYAAGGPLSRAL-AGRR---------VPPHVLVNWAVQIA--RGMHYLH---CEALVPV IHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHK--------TTQ---------- ---------MS-A-AGTYAWMAPEVI-KAST--FSKGSDVWSFGVLLWELLT-GEVPYRG ID----CLA--VAYGVAVN------K-LT------------------------------- ------------------------LPIP----STCPEP-FAQLMA--DCWAQDPHRRPDF A---------------------------------------------S-ILQQLEALEAQV L-REMPRDSFHSMQEGWKREIQGLFDELRAK-EKELLSREEELTRAAREQRSQAEQLRRR EHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRA--RDGGERISMPLDFK HRITVQASPGLDRRRNVFEVGA---GDSPTFPRFRAIQLEPAEPGQAWGRQS---PRRLE DSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEA---------------TWYLDSDDSS PLGSPSTPPMLNGNLPR-P--SPEPEEPRRPG---------------------------- ----------PTERGSGSGTPKLIQRALLRGTALLASLGLGRDLQPPG------------ -----GSGRERVEQPSPTPPRSSLPLPTPSPTEPPPSPLIRFSSETPET--PASPLSPDA SGPAAPAPPLLLELGVPAAGQPSAKSRRREEERRAS------------------------ -------------------------------------AVSPPPGISRSAPGTPGTPRSPP LGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDS----- -----------------PPANPFRGAPQDCRAQTKDVG--AQAPWAPEAGP >O_cuniculus_ENSOCUP00000002445 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MPCYIHQLPAWVLDDLCRNMDT-LNEWDWM QF---------------------------ASYV---------ITDLTQLRKIKSLERVQ- -GVSITRELLWWW-SMRQATV------------------------------------PQL VDL----LRRLQLY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAA QIVLDWKP----ALETGSSSPPSLD-------PVLPGRPET---SA---------EEEQP VG---------PAGQ---------------------------PSTXXXXXXXXXXX---- -----------------------------------------XXXX--------------- ------------------------------------------------------------ -----------------------------XXXXXXXXX-----XXX--XXXXX------- -------XXX--RFG--------------------------------P-------SVLQ- ----Q------------------------------------------------------- ------------------------------------------------------------ ------------------------------------EPLF-LAGDSLFWREADVVQATKD FS-----------------P------SHRISQGTFADVYRGER------HGK--LYVFKT VREG--ACSS---PG--SIERFFQA---EMEMCCR--CCHPSVLPLLGFCRGR-GFHSLV YPYMAHGSLQDRL-HGQG-----GSDPLSWPQRVGICSGLL--QAVQHLH---SL---DI IHSNIKXXXXXXXX--------XXXXXXXXXXX-XXXXX-----XXXXXX--XXX----- --------XXX-XXXXXXXXXXXXXX-XXXX--XXXXXXXXXXXXVLAEVLT-GIPAVDS SR----SPA--YLKDLLLR------EIPS-SAPSPCSRRAAV----------EVEAVREI CAQFLDGR---------------AGRPP----AGCTEA-LA-AAC--LCLR---RRNASL D---------------------------------------------E------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_nigroviridis_ENSTNIP00000007264 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------CSPCDDSVV-FHPAR-RGLTAGRA VVWGLSPHTSY--------AFTVQAVNGVSS-------LSQSEPAAVRVNVTSSRD---- -----------V----------------------------PPPVL--------------- -GLRRT-AASETSLSLEWNVPFVQNQHPIL--DYQLRYSTK------------------- ---------------DGEEAGRWRYVSSKSSSVVVTGLQG---ALQYQVQVRARSG-AGY GSFSPASTFNTLPDG-TTLSRPCLNHSKLEAEEGLINPRCCLNVPRSQFGTFEGSCVPWC SLIPWESGLDSGSLCLPQMLLVPRWFGPGSPSPWPPCCCSLGRVGLRSATGHTGSIRMEK LDTEGDNNIPVQNKEFCSCWKSKFSRRMKDADVNDSAGHYQMGQSEL------------- ------------------------------------FSGGAMKVYIDPFTYEDPNEAVRE FA-------------KEI-EASFVKIEEVIGAGEFGEVCRGRLRVPGR-KEN--YVAIKT LKGGY--------TE--KQRRDFLS---EASIMGQ--FQHPNIIHLEGVITTS-CPVMIL TEFMENGALDSFL-RMND-------GQFTPIQLVGMLRGIA--AGMKYLS---DM---SF VHRDLAARNILVNS--------NLVCKVSDFGLSRFLTE----SSSDPTY---------- --------TSSLGGKIPIRWTAPEAI-AYRK--FTSASDVWSYGIVMWEVMSYGERPYWD MS----NQD--VINAIEQD--------YR------------------------------- ------------------------LPPP----PDCPAS-LHALML--DCWQKERANRPRF S---------------------------------------------E-VVASLDRLIRNP A--------SLKVTHPDGPGPSQPLLDQRVP-PPPQGCGSVSELRAIKMERYQQDFLQAA SPAWTWLL---------------------------------------------------- --ISTRR----DLLRVGVTLAGHQKKILSSIQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >E_caballus_ENSECAP00000021660 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------VTLMDTSTAQGELGW--LLDP----PEDGWSEVQQM -LNGTPLYMYQDCPVQEGGDTDHWLRSNWIYRGEEASRVHVELQFTVRDCKSFPGGARPL GCKETFNLLYMESDQDVGIQ----LRRPLFQKVTTVAADQSFTIRDLASGSVKLNVEHCS LGLLTRRGLYLAF-HNPGACVAL-VSVRVFYQRCPEAVHGLAQ---FPDTLPR---LGGL VEVAGTCLPHAQASPG--PSGAARMHCSPDGEWL-VPVGRCHCEPGYEEGGDGEGC---- ------------------------------------------------------------ ----------------------------LACPGGSYRADMGAPHCLQCPQH--------S TAETEGATI---C----TCEDGHYRAPGEGPQAACTRPP-----SAPQNLSFSV---LGT KLSLSWQPPADTGGRQDVRYSVGCSQCRGAALDGGPCQPCGGSVR-FSPSA-DGLAAPAV RVDGLEPYANY--------TFNIAAQNGVSG-------LDTSKPASALLSISMGHA---- -----------E----------------------------SLSGL--------------- -SLRLV-KKEPRQLELTWAGSWPRSPGGNL--SYELHVLNQ------------------- ---------------DEERHQM-----VLEPRVLLTELQP---DTTYIVRVRMLTP-LGP GPFSPDQEFRTSPPV-SRSLT-------G----------------GEIVAVIFG-LLLGV G-----LLLGILV---FRSR---------------------------------------- -------------------------KSKRRRQQRPRDHVTSVNR---------------- ------------------------------------EDKLWLKPYVDLQAYEDPAQGALD FT-------------QEL-DPTWLIVDTVIGEGEFGEVYRGTLRIPSQ-DCK--TVAIKT LKDTS--------PD--GQWWNFLR---EATIMGQ--FNHPHILHLEGVITKR-KPIMII TEFMENGALDAFL-RERE-------DQLIPGQLVAMLQGIA--SGMNYLS---DH---NY VHRDLAARNILVSQ--------NLCCKVSDFGLTRFL-D----N-SDGTY---------- --------ETQ-GGKIPIRWTAPEAI-AHRI--FTTASDVWSFGIVMWEVLSFGDKPYGE MS----NQE--VMKSIEDG--------YR------------------------------- ------------------------LPPP----VDCPAP-LYELMK--NCWAYDRARRPHF H---------------------------------------------Q-LKAHLDHLLANP H--------SLRTIANFDPRVTLRLPSLSGS-DGIPYRSVPEWLESIRMKRYILHFHSAG LDTMECVL---------------------------------------------------- --ELTAE----DLVQMGITLPGHQKRILCSIQGFKD------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >M_domestica_ENSMODP00000009423 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AAEPL--WTAVFD YEAAGEEELTLRR--------------------------------------------GDQ VRV----LSQDWAV---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SGD EGWWTGQLLGGRVGVFPSNYVVAP------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GVPAPAPSG LPLP-----------REI-PFGELQLEEIIGVGGFGKVYRARW------HGE--EVAVKA ARLD--PERD---PA--ATAEQVAR---EARLFGA--LCHPNIIALRGACLRP-PHLCLV MEYARGGPLSRAL-AGRR---------VPPHVLVNWAVQVA--RGMAYLH---SGAPVPI IHRDLKSINILILDAFENGDLSDTVLKITDFGLAREWHK--------TTK---------- ---------MS-A-AGTYAWMAPEVI-RLSL--FSKSSDVWSFGVLLWELLT-GEVPYRE ID----ALA--VAYGVAMN------K-LM------------------------------- ------------------------LPIP----STCPEP-FVRLLE--ECWDPEPHQRPDF D---------------------------------------------S-ILSRLEAIERSA L-FQMPLESFHSLQEDWKQEIQHMFDDLRTK-EKELRSREEELLRAAQEQKWQEEQLRRR EQELAEREMDIVGRELHLLMDQLSQERPRVKKRRGHFRRSRLKL--RD-SNNISLPS--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_rubripes_ENSTRUP00000029568 ------------------------------------------------------------ ----------------------------------------------------------MA -LRRLLLL--LFICQGFSRSQSEEQILLDMSASGSELGW--LT------TDDGWEIVQTV -VNGTLFYSYSVCNIDS-PEQDNWLRTTFIQRRPGISRVSVELRFVVRDCNTFDGA--SV ACKETFNLYISEADADVGTN----FRKGQFRKVATIASDEVTH-----GRVLKVNAETRT VEPLSRRGFYLAF-QDMGACVAL-LSARVYYKTCPSTVQSLAE---FPETVA-----DAL KEVEGVCVENAISP-----ATP-RNYCSADGEWV-VPVGQCQCLAGYESTGDS--C---- ------------------------------------------------------------ ----------------------------QACKPGYFKPSIQSKFCQVCPDN--------T KPSEAGATE---C----QCEEGFYRSPSDPPTSPCSACPPTAPPSAPRDLSSSALS-AEG RLQLSWSPPLVTGGRSDLTYSVVCEHCN-----GGQCVPCGDKIR-FEPGP-AGLQDTLV VVTDLDAHLNY--------TFTVEAHSGVSQF--------STEKAAASLTTALDYT---- -----------GELRRHKAMPQMFLSFFSHTFHPEFLATEKPGLTPHRGIWFHPLSPQGF DLISLGYDRSATSLALSWTLS-RRPPAHINH-RYELMYRRKVSQRFMLLLFSSPSPRLTP KLPADSSTLVLQDDDGERDVTTYTVLILEKNSVQIADLTP---DTTYIVRVQVLGSEVNP GSHSVEHEFQTSPLA-ESQ---------I----------------QNKSTLVMG-AVFGI MVILL-VVVAVLL---LRRR---------------------------------------- -------------------------KMNLRGRGGAEDPYFSPGK---------------- -----------NPHSHLCCFQVRSVRKDSHVFGPTLDQLKPLKTYVDPHMYEDPNIAIQK FV-------------TEI-DPSAISKQKVIGVGEFGEVFRGVMKARGR-AEV--DVAIKT LKPGY--------SE--KQRLDFLS---EASIMGQ--FSHPNIIRLEGVVTKF-KHIMIV TEYMDNGALDTYL-KGRD-------GEIPPYQLVGMLRGIA--AGMQYLS---DM---SY VHRDLAARNILVNS--------NLECKVSDFGLSRVLED----D-DEGTY---------- --------TTR-GGKIPIRWTAPEAI-AYRK--FTSASDVWSFGIVMWEVMAFGERPYWD MS----NHE--VMKTINEA--------FR------------------------------- ------------------------LPAP----MDCPSA-IYQLML--QCWQHDRSKRPRF L---------------------------------------------D-IVNFLDKLLRSP E--------SLKTIADFDPRVSIRLPSTSGC-DGTVFRTVPEWLESIRMSQYSESFARAG ITSMEQVL---------------------------------------------------- --GLRHE----DIRNIGVRLPGHLKRIAYSILGLKDETSSLSV----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >C_familiaris_ENSCAFP00000019770 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MEPLKNLFLKSPLGSWNSSGG GG---------------------------SGGSGGGWPEGSPKT-AAYANPV--WTALFD YEPNGQDELALRK--------------------------------------------GDR VEV----LSRDAAI---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SGD EGWWAGQ-VGGQVGIFPSNYVS-R------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GGG----------- ---PPP---------CEVASFQELRLEEVIGIGGFGKVYRGSW------RGE--LVAVKA ARQD--PDED---IS--VTAESVRQ---EARLFAM--LAHPNIIALKAVCLEE-PNLCLV MEYAAGGPLSRAL-AGRR---------VPPHVLVNWAVQIA--RGMHYLH---CEALVPV IHRDLKSNNILLLQPIEGDDMDHKTLKITDFGLAREWHK--------TTQ---------- ---------MS-A-AGTYAWMAPEVI-KAST--FSKGSDVWSFGVLLWELLT-GEVPYRG ID----CLA--VAYGVAVN------K-LT------------------------------- ------------------------LPIP----STCPEP-FAQLMA--DCWAQDPHRRPDF A---------------------------------------------S-ILQQLEALEAQV L-REMPRDSFHSMQEGWKREIQGLFDELRAK-EKELLSREEELTRAAREQRSQAEQLRRR EHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRA--RDGGERISMPLDFK HRITVQASPGLDRRRNVFEVGA---GDSPTFPRFRAIQLEPAEPGQAWGRQS---PRRLE DSSNGERRACWAWGPSSPKPGEAQNGRRRSRLDEA---------------AWYLDSDDSS SLGSPSTPPMLNGNPPR-PRGSPEPEEPRRPG---------------------------- -----------------LGTPKLIQRALMCGTALLASMGLGRDLE--------------- ---------------TQLTPRA---LPSVSPAEPPPAPLFRLSPKTPDA--PASPL---- -------SPLLLELGVP-VGQRSAKSPRRDGERRGS------------------------ -------------------------------------TVSPPPGISRSAPGTPGTPRSPP LGLISRPRPSPLRSRIDPWSFVSAGPRPSPLSSPQPAPRRAPWTLFPDSDPFWDS----- -----------------PPANPFRGGPQDCRAQTKDIG--AQAPWAPEAGP >A_carolinensis_ENSACAP00000006222 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------VVLLDFAKAQGDLGW--LNHP----FGKGWDLLQNV -MNESLIYMYSVCNVME-GDQDNWLRTNWIYRS-EAERIFIELQFTVRDCNSFPGG--TG TCKETFNLFYAESDVDYGIN----FQKRQFRKIATIAPDEITVREDFDTRNVKINVERRS VGPLTRKGFYLAF-QDIGACVAL-LSVRIYYKKCPETIHNMAA---FPETIAG-ADSQSL AEVAGACVQDAVS------REP-LLHCNSDGEWR-VP-GRLRSQEGSELLLPSF------ ------------------------------------------------------------ ----------------------------AACSPGFFKEEVSNSPCSRCPSH--------T LPSAAGSTS---C----PCEEGFFRAASDPLSTPCTRPP-----SAPRSVTALG---LGA KVQLRWLPPLDAGGRSDLTYSVSCEQCWP---ESGECRPCDPGLR-FSDHP-HSFAGTSL TVSDLEPHVNY--------TFTVEAQNGVSSF--------STRRSYGAASISVNQT---- -----------E----------------------------PPRVT--------------- -SVTMD-GRTATSLTLSWTVP-PRQRSHVW--KYQVTYKKK------------------- -----------------KDEHSYSVVRCDGNSVTLPKLTP---RTKYVVSVQALIQ-EGH GAHSVEHEFETLPE--RSD---------G----------------ANSAAVLGG-SIAAC LAMVL-FIAAFVF--FLRRR---------------------------------------- -------------------------RKNLRARQTPEDVYFSKS----------------- ------------------------------------DQLKPLKTYVDPHTYEDPNQAVLK FT-------------TEI-QPSCISRQKVIGAGEFGEVYKGTLR-SST-KEI--PVAIKT LKSGS--------TE--KQRIDFLS---EASIMGQ--FCHHNIIRLEGVVSKY-KPFLII TEYMENGALDKFL-QEKD-------GQFCVIQLVGMLRGIA--SGMRYLA---SM---NY VHRDLAARNILVDS--------QLVCKVSDFGLSRVLED----D-PDATY---------- --------TTS-GGKIPIRWTAPEAI-SHRK--FTSASDVWSYGIVMWEVMSYGERPYWE LS----NSE--VMKAINEG--------YR------------------------------- ------------------------LPAP----LDCPSA-VYQLMM--RCWQQERSHRPRF N---------------------------------------------D-IVSILDKLIRAP E--------SLKTLAEFDPRVSIRLPSTSGS-EGIPFRTVGEWLESIKMHQYTEHFLSTG YNSIEKVV---------------------------------------------------- --QMTND----DIKSIGVRLPGHQKRIAYSLLGLKEQAGAIGIPL--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >O_latipes_ENSORLP00000008682 ------------------------------------------------------------ -------------------------------------------------SDSNQYLPPEF LSKSEKNLIICIFSVVTHHCIFSTEVLMNTKTETSDLKW--TIFSRSK---PEWEEISGL DEEGISVRTYQICQT-D-SSSSHWLRSGFIQRQ-GASQVYVELRFTMMECSSRGTH--HR SCKETFNLYYYQADSNEATATYPPWMENPYTKVDTVAADFLLRK----GGERKFNVKTLR LGPLSKRGFYLAF-QAQGACMAL-LSVRVFFKKCPPLVSALSS---FPETV----PRTLV QEAQGECVKNAAQQGP--RPRPPKLFCGEDGQWVGQPTTSCACLPGYEPTEGQTLC---- ------------------------------------------------------------ ----------------------------TACPVGQFKSST-EGQCQSCPGF--------S HATSRGASV---C----ACRPGFLRAQSDPPNSSCTKTP-----SAPRGINPRI---NAT TLTLEWNEPLDSGGRTDLSYSVRCSICRS---PKSPCQPCKDGVI-YRPAQ-EDLLVRRV EVWDLLPHTTY--------TFTIQALNGVSK-------LSNKEPASESINITTNHE---- -----------V----------------------------PSLVS--------------- -VIRKS-DSTESSLTLHWSVP-AQPRYNVL--QYQLRYCEK------------------- ---------------DRRSDDQCFFTESSRNQVVLTDLRR---ATQYEVQVRARTQ-AGY GSFSPAAIFRTLPDG-EKNAL----QKIV----------------SKIIFLVPGILIAVG MLLLA-TFVFVAVYCIRQRMEFP------------------------------------- -------------------------FLGKASIY---IPTYHTG----------------- -----------------------------------------VKVYIDPFTYEDPNEAVRE FA-------------KEI-DVSFVKIEEVIGAGEFGEVCRGRLKIPGK-KEN--YVAIKT LKGGY--------TD--KQRRDFLS---EASIMGQ--FHHPNIIHLEGIITAS-CPVMIL TEFMENGALDSFL-RMND-------SQFTPIQLVGMLRGIA--SGMKYLA---EM---SY VHRDLAARNILINS--------NLVCKVSDFGLSRFLQE----NSSDPTY---------- --------TSSLGGKIPIRWTAPEAI-AFRK--FTSASDVWSYGIVMWEVMSFGERPYWD MS----NQD--VINAIEQD--------YR------------------------------- ------------------------LPPP----PDCPTH-LHQLML--DCWQKDRSARPRF S---------------------------------------------D-LVSALDKLIRNP A--------SLKIVAQEGAGPSYPLLDQRAPLALSPCTSVGDWLRSIKMERYEDSFLQAG FNSVDQLA---------------------------------------------------- --QLSTQ----DLLHMGVTLAGHQRKILSSVQTLTFQNKNTATVTF-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >P_pygmaeus_ENSPPYP00000003540 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MEPLKSLFLKSPLGSWNGSGS GG---------------------------GGGGGGGRPEGSPKA-AGYANPV--WTALFD YEPSGQDELALRK--------------------------------------------GDR VEV----LSRDAAI---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SGD EGWWAGQ-VGGQVGIFPSNYVS-R------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GGG----------- ---PPP---------CEVASFQELRLEEVIGIGGFGKVYRGSW------RGE--LVAVKA ARQD--PDED---IS--VTAESVRQ---EARLFAM--LAHPNIIALKAVCLEE-PNLCLV MEYAAGGPLSRAL-AGRR---------VPPHVLVNWAVQIA--RGMHYLH---CEALVPV IHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHK--------TTQ---------- ---------MS-A-AGTYAWMAPEVI-KAST--FSKGSDVWSFGVLLWELLT-GEVPYRG ID----CLA--VAYGVAVN------K-LT------------------------------- ------------------------LPIP----STCPEP-FAQLMA--DCWAQDPHRRPDF A---------------------------------------------S-ILQQLEALEAQV L-REMPRDSFHSMQEGWKREIQGLFDELRAK-EKELLSREEELTRAAREQRSQAEQLRRR EHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRA--RDGGERISMPLDFK HRITVQASPGLDRRRNVFEVGP---GDSPTFPRFRAIQLEPAEPGQAWGRQS---PRRLE DSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEA---------------TWYLDSDDSS PLGSPSTPPALNGNPPR-P--SLEPEEPKRPV---------------------------- ----------PAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPG------------ -----GPGRERGEPPTTPP----TPTPAPCPTEPPPSPLIRFSLKTPDS--PPTP----- -------APLLLDLGIP-AGQRSAKSPRREEEPRGG------------------------ -------------------------------------TVSPPPGTSRSAPGTPGTPRSPP LGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDS----- -----------------PPANPFRGGPQDCRAQTKDMG--AQAPWVPEAGP >M_musculus_ENSMUSP00000004156 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MEPLKNLFLKSPLGSWNGSGS GG---------------------------GGGTGGVRPEGSPKATAAYANPV--WTALFD YEPNGQDELALRK--------------------------------------------GDR VEV----LSRDAAI---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SGD EGWWAGQ-VGGQVGIFPSNYVS-R------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GGG----------- ---PPP---------CEVASFQELRLEEVIGIGGFGKVYRGSW------RGE--LVAVKA ARQD--PDED---IS--VTAESVRQ---EARLFAM--LAHPNIIALKAVCLEE-PNLCLV MEYAAGGPLSRAL-AGRR---------VPPHVLVNWAVQIA--RGMHYLH---CEALVPV IHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHK--------TTQ---------- ---------MS-A-AGTYAWMAPEVI-KAST--FSKGSDVWSFGVLLWELLT-GEVPYRG ID----CLA--VAYGVAVN------K-LT------------------------------- ------------------------LPIP----STCPEP-FAQLMA--DCWAQDPHRRPDF A---------------------------------------------S-ILQQLEALEAQV L-REMPRDSFHSMQEGWKREIQGLFDELRAK-EKELLSREEELTRAAREQRSQAEQLRRR EHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRA--RDGGERISMPLDFK HRITVQASPGLDRRRNVFEVGA---GDSPTFPRFRAIQLEPTESGQTWGRQS---PRRLE DSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEA---------------TWYLDSDDSS PLGSPSTPPALNGNPPR-P--SPEPEEPRRAG---------------------------- ----------PTERGNSSGTPKLIQRALLRGTALLASLGLGRDLQPPG------------ -----GLSRERGESPTAPPPAQ---MPSPCPPELPSTPLIRLSQTTPDAHSSPTP----- -------GPLLLDLGVP-SGQPSAKSPRREET-RGR------------------------ -------------------------------------TVSPPPGISRSAPGTPGTPRSPP LGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDS----- -----------------PPANPFRGGSQDCRTQTKDMG--AQAPWAPEAGP >M_mulatta_ENSMMUP00000009715 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MEPLKSLFLKSPLGSWNGSGS GG---------------------------GGGSGGGRPEGSPKA-AGYANPV--WTALFD YEPSGQDELALRK--------------------------------------------GDR VEV----LSRDAAI---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SGD EGWWAGQ-VGGQVGIFPSNYVS-R------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GGG----------- ---PPP---------CEVASFQELRLEEVIGIGGFGKVYRGSW------RGE--LVAVKA ARQD--PDED---IS--VTAESVRQ---EARLFAM--LAHPNIIALKAVCLEE-PNLCLV MEYAAGGPLSRAL-AGRR---------VPPHVLVNWAVQIA--RGMHYLH---CEALVPV IHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHK--------TTQ---------- ---------MS-A-AGTYAWMAPEVI-KAST--FSKGSDVWSFGVLLWELLT-GEVPYRG ID----CLA--VAYGVAVN------K-LT------------------------------- ------------------------LPIP----STCPEP-FAQLMA--DCWAQDPHRRPDF A---------------------------------------------S-ILQQLEALEAQV L-REMPRDSFHSMQEGWKREIQGLFDELRAK-EKELLSREEELTRAAREQRSQAEQLRRR EHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRA--RDGGERISMPLDFK HRITVQASPGLDRRRNVFEVGP---GDSPTFPRFRAIQLEPAEPGQAWGRQS---PRRLE DSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEA---------------TWYLDSDDSS PLGSPSTPPALNGHPLR-P--SLEPEEPKRPL---------------------------- ----------PAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPG------------ -----SQGRERGDPPTTPP----TPMPAPCPTEPPPSPLIRFSPKTPDS--PPTP----- -------APLLLDLGIP-AGQRSAKSPRREEEPRGG------------------------ -------------------------------------TVSPPPGTSRSAPGTPGTPRSPP LGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDS----- -----------------PPANPFRGGPQDCRAQTKDMG--AQAPWVPEAGP >P_troglodytes_ENSPTRP00000006703 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MEPLKSLFLKSPLGSWNGSGS GG---------------------------GGGGGGGQPEGSPKA-AGYANPV--WTALFD YEPSGQDELALRK--------------------------------------------GDR VEV----LSRDAAI---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SGD EGWWAGQ-VGGQVGIFPSNYVS-R------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GGG----------- ---PPP---------CEVASFQELRLEEVIGIGGFGKVYRGSW------RGE--LVAVKA ARQD--PDED---IS--VTAESVRQ---EARLFAM--LAHPNIIALKAVCLEE-PNLCLV MEYAAGGPLSRAL-AGRR---------VPPHVLVNWAVQIA--RGMHYLH---CEALVPV IHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHK--------TTQ---------- ---------MS-A-AGTYAWMAPEVI-KAST--FSKGSDVWSFGVLLWELLT-GEVPYRG ID----CLA--VAYGVAVN------K-LT------------------------------- ------------------------LPIP----STCPEP-FAQLMA--DCWAQDPHRRPDF A---------------------------------------------S-ILQQLEALEAQV L-REMPRDSFHSMQEGWKREIQGLFDELRAK-EKELLSREEELTRAAREQRSQAEQLRRR EHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRA--RDGGERISMPLDFK HRITVQASPGLDRRRNVFEVGP---GDSPTFPRFRAIQLEPAEPGQAWGRQS---PRRLE DSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEA---------------TWYLDSDDSS PLGSPSTPPALNGNPPR-P--SLEPEEPKRPV---------------------------- ----------PAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPG------------ -----GPGRERGESPTTPP----TPTPAPCPTEPPPSPLIRFSLKTPDS--PPTP----- -------APLLLDLGIP-AGQRSAKSPRREEEPRGG------------------------ -------------------------------------TVSPPPGTSRSAPGTPGTPRSPP LGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDS----- -----------------PPANPFRGGPQDCRAQTKDMG--AQAPWVPEAGP >C_familiaris_ENSCAFP00000005359 ------------------------------------------------------------ ---------------------------------------------------------MER RWPLGLGLLLLLRAPLPPGARSEEVTLMDTSTAQGELGW--LLDP----PEDGWSEVQQI -LNGTPLYMYQDCPVQAGGDTDHWLRSNWIYRGEEASRVHVELQFTVRDCKSFPGGAGPL GCKETFNLLYMESDQDVGIQ----LRRPLFQKVTTVAADQSFTIRDLASGAVKLNVERCS LGHLTRRGLYLAF-HNPGACVAL-VSVRVFYQRCPEVVQGLAR---FPNTLPG---PGGL VEVAGTCLPHAQVSPG--PSGAPRMHCSPDGEWL-VPVGRCHCEPGYEEGGSGEGC---- ------------------------------------------------------------ ----------------------------LACPSGSYRADADAPHCVKCPGH--------S AAESEGATL---C----ICHSGHFRAPGEGPQVSCTRPP-----SVPRNLSFSV---LGT QLSLRWEPPADMGGRQDVRYSVGCSQCRGAAVDGGPCQPCGGSVR-FSPGA-SGLTAPAV RVNGLEPYANY--------TFNVEAQNGVSG-------LGTSTPASASLSVSMGHA---- -----------E----------------------------SLSGL--------------- -SLRLV-KKEPRQLELTWAGSRPRSPGANL--SYELHVLNQ------------------- ---------------DEERHQM-----VLEPRVLLTELQP---DTTYIVRVRMLTP-LGP GPFSPDHEFRTSPPV-SRGLT-------G----------------GEIVAIIFG-LLLGV A-----LLMGMLF---FRSR---------------------------------------- -------------------------KAQRRHPQRQRDRVAEVNR---------------- ------------------------------------EDKLWLKPYVDLQAYEDPAQGALD FT-------------QEL-DPGWLIVDTVIGEGEFGEVYRGTLKIPSQ-DCK--TVAIKT LKDTS--------PD--GQWWNFLR---EATIMGQ--FNHPHILHLEGVVTKR-KPIMII TEFMENGALDAFL-RERE-------DQLVPGQLVAMLQGIA--SGMNYLS---DH---NY VHRDLAARNILVSQ--------NLCCKVSDFGLTRLL-D----N-FDGTY---------- --------ETQ-GGKIPIRWTAPEAI-AHRT--FTTASDVWSFGIVMWEVLSFGDKPYGE MS----NQE--VMKSIEDG--------YR------------------------------- ------------------------LPPP----VDCPAP-LYELMK--NCWAYDRARRPSF H---------------------------------------------Q-LKAHLDQLLANP H--------SLRTIANFDPRVTLRLPSLSGS-DGIPYRSVPEWLESIRMKRYILHFRSAG LDTMECVL---------------------------------------------------- --ELTAE----DLAQMGITLPGHQKRILCSIQGFKD------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >H_sapiens_ENSP00000309597 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MEPLKSLFLKSPLGSWNGSGS GG---------------------------GGGGGGGRPEGSPKA-AGYANPV--WTALFD YEPSGQDELALRK--------------------------------------------GDR VEV----LSRDAAI---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SGD EGWWAGQ-VGGQVGIFPSNYVS-R------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GGG----------- ---PPP---------CEVASFQELRLEEVIGIGGFGKVYRGSW------RGE--LVAVKA ARQD--PDED---IS--VTAESVRQ---EARLFAM--LAHPNIIALKAVCLEE-PNLCLV MEYAAGGPLSRAL-AGRR---------VPPHVLVNWAVQIA--RGMHYLH---CEALVPV IHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHK--------TTQ---------- ---------MS-A-AGTYAWMAPEVI-KAST--FSKGSDVWSFGVLLWELLT-GEVPYRG ID----CLA--VAYGVAVN------K-LT------------------------------- ------------------------LPIP----STCPEP-FAQLMA--DCWAQDPHRRPDF A---------------------------------------------S-ILQQLEALEAQV L-REMPRDSFHSMQEGWKREIQGLFDELRAK-EKELLSREEELTRAAREQRSQAEQLRRR EHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRA--RDGGERISMPLDFK HRITVQASPGLDRRRNVFEVGP---GDSPTFPRFRAIQLEPAEPGQAWGRQS---PRRLE DSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEA---------------TWYLDSDDSS PLGSPSTPPALNGNPPR-P--SLEPEEPKRPV---------------------------- ----------PAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPG------------ -----GPGRERGESPTTPP----TPTPAPCPTEPPPSPLICFSLKTPDS--PPTP----- -------APLLLDLGIP-VGQRSAKSPRREEEPRGG------------------------ -------------------------------------TVSPPPGTSRSAPGTPGTPRSPP LGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDS----- -----------------PPANPFQGGPQDCRAQTKDMG--AQAPWVPEAGP >B_taurus_ENSBTAP00000038340 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MSSLGTS FV--------------QI-KFDDLQFFENCGGGSFGSVYRAKWI----SQDK--EVAVKK LLK-------------------IEK---EAEILSV--LSHRNIIQFYGVILEP-PNYGIV TEYASLGSLYDYI-NSNR------SEEMDMDHIMTWATDVAKGKGMHYLH---MEAPVKV IHRDLKSRNVVIAA--------DGVLKICDFGASRFHNH--------TTH---------- ---------MS-L-VGTFPWMAPEVI-QSLP--VSETCDTYSYGVVLWEMLT-REVPFKG LE----GLQ--VAWLVVEK------N-ER------------------------------- ------------------------LTIP----SSCPRS-FAELLH--QCWEADAKKRPSF K---------------------------------------------Q-IISILESMSLDS K-LSDQCNSFLHNKAEWRCEIEATLERLKKL-ERDLSFKEQELKERERRLKMWEQKLTEQ SNTPLLP-----------------------SFEIGAWTE-DDVYFWVQQLVRKG---DSS AEMSVYASLFKEN-----NITGKRLLLLEEE----DLKDMGIISKGHIIHLKSAIEKLTH DYLNLFHFPPLIKGSVGEPEENEEKIVNLELVFG-FHLKPGTGLQDCKWKMYMEMDGDEI AITYIKDVTFNTNLPDAEILKMTKPPFVMEKWIVGIVENQTVECTVTYESDVRTPKSTKH IHSIQWSRMKPQDEVKAVQLAIQTLFPNSEGTPGSRSDSNADCQWLDTL------RMRQI ASN-TSLQ------RSQSNPI-LASQFFPYFNDQD-SYAAAVRRTQVPIKYQQITP-INQ SRSSSPTQYGLTKNFSSLHL-NSRDSGFSSVNTDSSLE--RGQYSGRSRNKYDRASHSLN SSPRGRHSGKSQHSTPSRERYSGKFYRVSRSALNAHQSPDFKRSPD--ASHQPRTIPGMP LCT---DMDSRANEEESKVSEGGWTKVEYRK--KPHRP-SPAKSNRERPRGNFRGRRNF- --------------------------------------------------- >D_rerio_ENSDARP00000065550 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MT GIVHSATGQRVSPDLSEHTTNS-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------QRECQYEMSSLSAS FV--------------QI-PFDDIRFYENCGGGSFGSVYRAHWV----PQDK--EVAVKK LLK-------------------IDA---EAEILSV--LSHKNIIQFYGAILEA-PNYGIV TEYASRGSLYEYL-SSAD------SEEMDMDQVMTWAMEIA--KGMHYLH---AEAPLKV IHRDLKSRNVVLTA--------DNVLKICDFGASKMVSH--------TTH---------- ---------MS-L-VGTFPWMAPEVI-QSLP--VSETCDTYSYGVVLWEMLT-REVPFKG FE----GLQ--VAWLVVEK------H-ER------------------------------- ------------------------PTIP----SSCPAS-FADLMR--RCWNAEPKERPQF K---------------------------------------------Q-ILSTLETMKNDS K-LPDQCNSFLHNKAEWRCEIEETLERLKQL-ERELSCKEQELEERERRLTEWENRLMER SRSCTPV----------------------------------------------------- ------------------SLASEELI---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >G_gorilla_ENSGGOP00000011485 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MEPLKSLFLKSPLGSWNGSGS GG---------------------------GGGSGGGRPEGSPKA-AGYANPV--WTALFD YEPSGQDELALRK--------------------------------------------GDR VEV----LSRDAAI---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SGD EGWWAGQ-VGGQVGIFPSNYVS-R------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GGG----------- ---PPP---------CEVASFQELRLEEVIGIGGFGKVYRGSW------RGE--LVAVKA ARQD--PDED---IS--VTAESVRQ---EARLFAM--LAHPNIIALKAVCLEE-PNLCLV MEYAAGGPLSRAL-AGRR---------VPPHVLVNWAVQIA--RGMHYLH---CEALVPV IHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHK--------TTQ---------- ---------MS-A-AGTYAWMAPEVI-KAST--FSKGSDVWSFGVLLWELLT-GEVPYRG ID----CLA--VAYGVAVN------K-LT------------------------------- ------------------------LPIP----STCPEP-FAQLMA--DCWAQDPHRRPDF A---------------------------------------------S-ILQQLEALEAQV L-REMPRDSFHSMQEGWKREIQGLFDELRAK-EKELLSREEELTRAAREQRSQAEQLRRR EHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRA--RDGGERISMPLXXX XXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXEPAEPGQAWGRQS---PRRLE DSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEA---------------TWYLDSDDSS PLGSPSTPPALNGNPPR-P--SLEPEEPKRPV---------------------------- ----------PAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPG------------ -----GPGRERGESPTTPP----TPTPAPCPTEPPPSPLIRFSLKTPDS--PPTP----- -------APLLLDLGIP-AGQRSAKSPRREEEPRGG------------------------ -------------------------------------TVSPPPGTSRSAPGTPGTPRSPP LGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDS----- -----------------PPANPFRGGPQDCRAQTKDMG--AQAPWVPEAGP >M_domestica_ENSMODP00000000411 GAAFMAAAETGPDVALREATQRKLRKFERLRGQPVPPGQFWDVVVLTPADGDQEVAYQLQ LTRKLQRGELPLGVHYHVFADPTGAKI---GSTLCALQHLEEIYGEMWSSFTILLIH--- --SDEWKRKVSESYLMVTERLEEDLQIQEPETQEMRLVFSSDEALSKV-----------N LNYRTENGLSLLHLCCICGGTKAHIRSLMLKGLRP--------SRLTRNGFTALHLAVYM DR---------------------------TDLVTGLLHSG-ADVQQAGYGALTALHVATL AGHLQAANVLLQHGAYVNVQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVGGEVGDRP LHL----ASAKGFL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NIA KLLMEEGSKAD-----VNAQDNEDHVPLHFCSRFGHHEMVKFLLQSDFEVQPHTA--NIY GDTPLHLACYNGKFEVAKEIIQVSGTESLAKENIFSETAFHSACT-YGRSIELVKF---- ----------------------------------------LLDQNVVSVNHQGRDGHTGL HSACYHGHIRLVQFLLDSGADMNLVA----------------CDPSRSSGD--------- -------------KDEQTCLMWAYEKGHDAIVTLLKHY-K---RPQDELPCNEYSQPGG- -DGSYVS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------VPSPLGKIKSMTKE KA-DVLLLRAGLPSHFHL-QLSEIEFHEIIGSGSFGKVYKGRC------RNK--MVAIKR YRA---HTYC---SK--SDVDMFCR---EVSILCR--LNHPCVIQFVGACLNDPSQFAIV TQYISGGSLFALL-HEQK-------RILDLQSKLIIAVDVA--KGMEYLH----NLTQPI IHRDLNSHNILLYE--------DGHAVVSDFGESRFLQS--------PDE----D----- --------NLT-KQPGNLRWMAPEVFTQCTR--YTIKADVFSYALCLWELLT-GEIPFAH LK----PAA--AAADMAYH------H-IR------------------------------- ------------------------PPIG----YSIPKP-ISSLLM--RGWNACPEGRPEF S---------------------------------------------E-VVTKLEECLCNI E-LMSPASSNSSGSLSPSSSSDCLESRGGPS-RSHVAALRSRFE-LEYALNARSCMYWSQ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_nigroviridis_ENSTNIP00000007193 ------------------------------------------------------------ -----------------------------------------------MYRHILYVFAIMP YFYWLSSKSEGFAFEELCWSLTPILTPGVSILRTSHRDSVTHRWLDV------------T FPLAPPPTFKCRNPTVVTVTTRPSSCRKFLSNSPSSQIPHTVTLVSIPGLDDGNEEDKSR GF---------------------------SVALDQLIGPAGRLSPENTHTLRVSQVDADC ISPSVKNSIHVG---------------------------------------------DRI LEINGTPVHNLPLD---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------EID SLIQETSQRLQLTIEHDPT-------------DRDRREAPPGLTIKWMAVCPPQC----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------QTAQTQRSQSH---SPPTPTSAAADLHQGSP SS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------IDQNLRVVSKRTHR IF-----------------RPSDLIHGEVLGKGCFGQAIKVTHR----ETGE--VMVMKE LIRF---------DE--DTQKAFQK---EVKVLRC--LDHPNVLKFIGVLYKD-KRLNFI TEYIKGGTLGEII-KKMD-------SNFPWNLRVSFATDIA--AGMAYVH------SMNI IHRDLNSFNCLVQE--------DNTVVVADFGLSRFMVH--------DAHEEMLSVGTVS GLKKHDRRKRY-TVVGNPYWMAPEMI-NGKV--YDEKVDIFSFGIVLCEIIG-RVNADPD YL----PRA--MDYGLDVS------GFLE------------------------------- ------------------------HYCP----PDCPPA-FFPIAA--LCCDLDADKRPGF S---------------------------------------------T-LKEWLENLRMHL E------------------MGLALVSELDQL-QKDFWKKHGNLHSKNGLHAHGAASAGMS TAGEKEIRVQNRR----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >X_tropicalis_ENSXETP00000037643 ------------------------------------------------------------ ------------------------------------------------------------ ------MVPAVFVMLALSAVQGLEETLMDTKWTTSELAW--VAYPDSG-----WEEVSGY DEASNPIRTYQVCNVRD-GNQNNWLRTQFIPRQ-DVQRVYVELKFTVRDCNSLPNI--PG SCKETFNFFYYESDSDSASADSPFWMENPYMKVDTIAPDESFSRRDSG----RVNTKIRS FGPLSRTGFYLAF-QDLGACVSL-ISVRVFFKKCPRTIAGFAT---FPETVTG-AEATSL VIAPGTCVPNALEV-----SVPLKLYCNGDGEWM-VPVGACTCASGFEAAGKDTQC---- ------------------------------------------------------------ ----------------------------QACKRGTYKSKQGEGSCVPCPVN--------S RAISSAATI---C----SCQNGYYRADGESAETACTSVP-----SAPRHVISNV---NET SVVLEWAEPGHLGGRDDILYNVICKKCL-----ERLCSRCDDNVQ-FWPRQ-LGVTQRRV SVSHLQAHTKY--------SFEIQAVNGVSG-------KSPHIPNYYTVNITTNQA---- -----------A----------------------------PSAVP--------------- -MVQSH-GSSANSLTLSWAPP-ESPNGIIL--DYEIKYYPK------------------- ---------------GQSGAG--NTVTSQRTTVRMEAMTP---DTVYVVQVRARTV-AGY GAYSEPREFQTISED-GDRSS-------L----------------QEQVPMVVG-SVTAG LIFII-AVVIIVIVCFSRKQ---------------------------------------- -------------------------RNDAESEYTEKLQQYMV------------------ ---------------------------------------PGMKLYIDPFTYEDPNEAVRD FA-------------KEI-DISCVKIEEVIGAGEFGEVCRGRLKQAGR-REQ--LVAIKT LKAGY--------TE--QQRRDFLG---EASIMGQ--FDHPNIIRLEGVVTRS-RPVMIL TEFMENGALDSFL-RMND-------GQFTVIQLVGILRGIA--SGMKYLS---EM---NY VHRDLAARNILVNS--------NLVCKVSDFGLSRFLEN----SRSDPTY---------- --------TSSLGGKIPIRWTAPEAI-SYRK--FTSASDVWSYGIVMWEVMSYGERPYWD MS----NQD--VINAIEQD--------YR------------------------------- ------------------------LPPP----MDCPAA-LHQLML--DCWLRDRNLRPKF S---------------------------------------------Q-IVSSLDKLIRNA A--------SLKVTSPAQAGVSQQLLDRTVP-DYTTFPTVSDWLEAIKMGQYQENFLSAG FTSFHLVA---------------------------------------------------- --QMTAE----DLLRIGVTLAGHQKKLLNSVQDMRLQMSQTLPVQV-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >C_elegans_C24A1.3a ------------------------------------------------------------ --------------------------------------------------MGNYKSRPLT SCSDELKKKISEGYSVVRSRLSDDV----RSRSNLGWVDVQIAAFEKSLEDFKQHMCPEN AELKSTQLLSLFHIICAGHSDSQPEKLQFLIDNLPKESSITLISSQSANGFTPLHIAIYR GD---------------------------VAILKALIATKLVDLDQSGRHLLPALHLAAM IGDSEMLTILLNSGANIHVTDFVHFTALHCATYFGQENAVRTLISASANLNLGGAVNDRP IHL----AAAKGLT---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SIT KLLLEAKAD-------PLLADDEGNQALHYAAKSGSLVILNMLIKQVRGTNDRICARNLY GDTALHLSCYSGRLDIVKSILDSSPTNIVNMENVFSETPLHAACT-GGKSIELVSF---- ----------------------------------------LMKYPGVDPNYQGQDGHTAL HSACYHGHLRIVQYLLENGADQSLASRAFEGGALRQQAGPGTNRPSKVASAIMALNRSDT PSSNASYNSTVSLDDQQTPVIWAYERGHDAIVALLKHYAA---RTVEGDVCSEYSSG--- -ESSYTP----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------LPSPMGRLTSLTRD KA-DLLQLRSALPAPFHL-CLAEIEFQESIGSGSFGKVYKGTY------RGK--LVAVKR YRAM---AFG---CK--SETDMLCR---EVSILSR--LAHPNVVAFVGTSLDDPSQFAII TEFVENGSLFRRE-NGER----KNYRVMDPAFRLRISLDVA--RGMRYLH---ESAAKPV IHRDLNSHNILIHA--------DGRSVVADFGESRFVCQ--------RED----E----- --------NLT-KQPGNLRWMAPEVFSQSGK--YDRKVDVFSFALVIWEIHT-AELPFSH LK----PAA--AAAEMTYK------R-GR------------------------------- ------------------------PTLPNQPTAQFPAH-ILSLIP--QAWHPESSSRPDF V---------------------------------------------E-IVALLEPHVEST H-TDISAPST-------------------------VSQLTSQWEQLSVAPPPASKFPPIL SA-LHGIA---------------------------------------------------- -ATGTVEELRQ-----RIDNNGYVINKS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >C_elegans_Y48G1C.2.1 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MSNGNSYNHHHQFPMSIPISCSSHSIQSQSRMNTLNANRDLLSPG ND---------------------------VIVTRTVSPSFYSHGMPARDNVFRKDDHVRI LGNTTDPAWYRARNANQE---------------------------------------EGL VHADCVVRINGQAY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------D--------------------------------------------NGI VRMRASGCDVAPGAASTTSSTSSHHSTAANHQPWFHSMISRENTEKLLRGKPDGTFLVRE STNFPGDFTLCMSFHGKVEHYRIEQTSGGQLTCDKEEYFSNLTQLVSHYKRD-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------ADGLCHRLVTPIICETATFSSNGS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------SSFGSSSTVDLEDRTSVFRH AG-------------LVI-SSNDIDVGDTIGHGEFGDVRLGTY------KNR--KVALKV SKRH---------GN--GMLDSLLD---EAKFMVG--LSHPNLVTLVGVVLDD-VNVYMI TEYMANGNLIDLL-RSRG------RHALERRQLMMFAMDIC--QGMCYLE---SK---QI VHRDLAARNVLLDD--------DLVAKVSDFGLAKKANS--------QSH---------- --------DSA-SGKFPIKWTAPEAL-RHSQ--FTTKSDVWSFGILLWEIFSFGRVPYPR IP----IQD--VVRYIEKG--------YR------------------------------- ------------------------MEAP----EGCPPE-IFKVMN--ETWALSAQDRPSF G---------------------------------------------Q-VLQRLTTIRNTV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >D_rerio_ENSDARP00000037995 ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------WEEVSGY DDAMNPIRTYQVCNVRE-LNQNNWLRSDFIPRK-DVLRVYVEMKFTVRDCNSIPNI--PG SCKETFNLFYYESDSDSATATSPFWMENPYVKVDTIAPDESFSMLESG----RVNTKIRS FGPLSKAGFYLAF-QDLGACMSL-ISVRAFYKKCSTTIANFAV---FPETATG-AEATSL VIAPGTCVPNALEV-----SVPLKLYCNGDGEWM-VPVGSCTCMAGFEPAVKETQC---- ------------------------------------------------------------ ----------------------------QACSPGTFKSKQGEGLCSPCPPN--------S RTSSGAASI---C----SCRTGYYRADSDSPDSGCTTVP-----SAPRNVISSV---NET SLILEWSEPRDQGGREDLLYNVICKKCLP---ERGTCTRCDDNVD-ISPRH-LGLTERHV TIRNLQAHTQY--------SFEIQAVNGVAS-------KSPYAPQFASVNITTNQA---- -------------------------------------------VP--------------- -TVHLT-GASANTMTLSWLPP-EKPNGIIL--DYEIKYHEK------------------- ---------------DQGEAIA-HTMTAQHSYARIDGLKP---GTPYVVQVRARTV-AGY GRYSSPTDFGTNHQA-DADKA-------L----------------QEQLPLIVG-SLTAG LVFII-VVVVIAIVC-LRKRVFP------------------------------------- --------------------YIQKQRNGSESEYTEKLQQYIT------------------ ---------------------------------------PGMKVYIDPFTYEDPNEAIRE FA-------------KEI-DVSCVKIEEVIGAGEFGEVCRGRLKLPGR-REI--IVAIKT LKAGY--------TE--RQRRDFLS---EASIMGQ--FDHPNIIRLEGVVTKS-RPVMIV TEFMENGALDSFL-RLND-------GQFTVIQLVGMLRGIA--AGMKYLS---DM---NY VHRDLAARNILVNS--------NLVCKVSDFGLSRFLED----DPTDPTY---------- --------TSSLGGKIPIRWTAPEAI-AYRK--FTSASDVWSYGIVMWEVMSYGERPYWD MS----NQDQQVINAVEQD--------YR------------------------------- ------------------------LPPP----MDCPTA-LHQLML--DCWVKERNLRPKF S---------------------------------------------Q-IVNTLDKLIRNA A--------SLKDLQRMA---SQPLLDRCVP-DYTTFTTVGDWLDAIKMSRYRDNFRATV LQVMSVVM---------------------------------------------------- --LIAISSCEIDLLRIGVTLAGHQKKILGSIQDMRLQMNQTLPVQV-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >E_caballus_ENSECAP00000010161 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------ETLMDSTTATAELGW--IVHPPSG-----WEEVSGY DENMNTIRTYQVCNVFE-SSQNNWLRTKFIRRR-GAHRIHVEMKFSVRDCSSIPSV--PG SCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRS FGPVSRSGFYLAF-QDYGGCMSL-IAVRVFYRKCPRIIQNGAI---FQETLSG-AESTSL VAARGSCIANAEEV-----DVPIKLYCNGDGEWL-VPIGRCMCKAGFEAVENGTVC---- ------------------------------------------------------------ ----------------------------RGCPSGTFKANQGDEACAHCPIN--------S RTTSEGATN---C----VCRNGYYRADLDPLDMPCTTIP-----SAPQAVISSV---NET SLMLEWTPPRDSGGREDLVYNIICKSCGS---GRGACTRCGDNVQ-YAPRQ-LGLTEPRI YISDLLAHTQY--------TFEIQAVNGVTD-------QSPFSPQFASVNITTNQA---- -----------A----------------------------PTIIS--------------- -ISQAT-GRKKESEKESWSSR-KETKARFL--EDALVQVQE------------------- ---------------THAQKGC-ALIGGSRSPVMVQTLEDA--GTIWKEAAGARQV-GLA GLCSIWVLFRVQREA-AEGRQ-------Q----------------SEVVREAAG-SQRPG LGFHVHSTVLLIIVL-EQLS---------------------------------------- -------------------------FKGSDSEYFRLCRPYAAG----------------- ------------------------------------ELTPGMKIYIDPFTYEDPNEAVRE FA-------------KEI-DISCVKIEQVIGAGEFGEVCSGHLKLPGK-REI--FVAIKT LKSGY--------TE--KQRRDFLS---EASIMGQ--FDHPNVIHLEGVVTKS-TPVMII TEFMENGSLDSFL-RQND-------GQFTVIQLVGMLRGIA--AGMKYLA---DM---NY VHRDLAARNILVNS--------NLVCKVSDFGLSRFLED----DTSDPTY---------- --------TSALGGKIPIRWTAPEAI-QYRK--FTSASDVWSYGIVMWEVMSYGERPYWD MT----NQD--VINAIEQD--------YR------------------------------- ------------------------LPPP----MDCPSA-LHQLML--DCWQKDRNHRPKF G---------------------------------------------Q-IVNTLDKTIRNP N--------SLKAVAPLSSGINLPLLDRTIP-DYTSFNTVAEWLEAIKMGQYKESFANAG FTSFDVVS---------------------------------------------------- --QMVME----DILRVGVTLAGHQKKILNSIQVMRAQMNQIQSVEV-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_rubripes_ENSTRUP00000040014 ----------------------------------------------------MRLMLFCC TWKEERMGEEEGGGRLPVCAACKQRIYDEQYLQALNSDWHAICFRCCECSASLSRWYYEK DGRLFCKNDYWAKFGELCHGCNDPIATGLIMVAKSQESRGYHPECFTCLNCRTFIGDGDT YALVERSKLYCGHCYYQTVLTPES-----LPNSPSSQIPHTVTLVSIPGSDDGTNEHKGR GF---------------------------SVVVDQPISPPDGFGQEKGHTLRVSQVDVDF ISPNVKNSIHVG---------------------------------------------DRI LEINGTPIHNIPLE---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------EID LLIQETSQLLQLTIEHDPHGQGKEGGSSRAAHQMDGRLSPPLSRSPSPSL---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------PITQPPNPDIS---SLRTCIKAHSYSIDKSP SS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------NQKNISRSESLRAVSKRTHR IF-----------------RPSDLIHGEVLGRGCFGQAIKVTHR----ETGE--VMVMKE LIRF---------DE--ETQKAFQK---EVKVLRC--LDHPNVLKFIGVLYKD-KRLNFI TEYIKGGTLGEII-KKMD-------SNFPWNLRVSFATDIA--AGMAYLH------SMNI IHRDLNSFNCLVQE--------DNTVVVADFGLSRFMSQ--------DAHEDMLSLGTVS GLKKHDRRKRY-TVVGNPYWMAPEMI-NGKI--YDERVDIFSFGIVLCEIIG-RVNADPD YL----PRA--MDYGLDVS------GFLE------------------------------- ------------------------HYCP----PDCPPA-FFPIAA--LCCDLDADKRPYF S---------------------------------------------T-LREWLENLKMHL E------------------MDLALVSELDQL-QKDFWKKHNNLHSKKELPD--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >A_gambiae_AGAP002710-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----QP---------VEI-QYHELDLKEVIGVGGFSKVHRAFL------NGE--EVAVKA SRQ----DDE---FE--VARQNVLQ---EAKLFWS--LKHPNIVSLKGVCLDP-KTLCLV MEYARGGSLNKIL-AGRK---------IPPNVLVDWAIQIA--RGMKYLH---CEAPISV IHRDLKSSN--GSESIQHGHLLNKTLKITDFGLAREAYR--------TTR---------- ---------MS-A-AGTFAWMPPEVI-KSGT--YSKASDVWSYGVLLWELLT-GETPYKG FD----SLS--VAYGVAVN------T-LA------------------------------- ------------------------LPIP----KTCPES-WGKLMK--SCWEIDPHRRPSF K---------------------------------------------D-IEKDL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >O_latipes_ENSORLP00000011854 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MDAFKPALDNSSSPAAPSSEE -----------------------------ADAFRWPTPEHGPRS-AREAEPTAHWTAVFD YEATADDELSLRR--------------------------------------------GDL VEV----LSKDSLV---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SGD EGWWTGM-IADRVGIFPSNYVSKG------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------NRVPEEARDTSEQQ YPVPPLHL-------LEI-DFSELTLEEIIGVGGFGKVYRAVW------QGM--EVAVKA ARQD--PDED---LE--QTVESVRQ---EAKLFAM--LSHPNIMALLGLCLQE-PNLCLV MEYARGGALNRAL-AGKR---------IPPCTLVDWAVQTA--RGMNYLH---NQAIVPI IHRDLKSSNILILERVEMEDLSNKTLKITDFGLAREWHR--------TTK---------- ---------MS-A-AGTYAWMAPEVI-RAST--FSKGSDVWSYGVLLWELLT-GEVPFRG ID----GLA--VAYGVAMN------K-LS------------------------------- ------------------------LPIP----STCPEP-FARLMEATDCWSSDPHCRPSF S---------------------------------------------T-ILDHLTAIEESG F-FEMPAKSFHSLQDDWKLEIQEMFDQLRAK-EKELRSWEEELTRAAMQQKCQEEALRRR EQELAEREIHILERELNIIIHQLYQEKPRVESRQGKFRRNRLKL--KD-GNRISLPSDFQ HKITVQASPSHDPRRSLLSSSSSPPTSPPMLPRLRAIQLTPGEGAAAWGHNTVFQQDEDE LERKGSRKKGRSRGTGIHREHSADASVK---------------------------PPHEG SRQRSCSAPNLRRSPRHSPAVPGVPRLVEMENEDCCFSTEPGAGPAQSYLCVPFQKESHG SSDSNGDEYCPGGQLPPTPPCKKTELVLLGCGALLAAVGLGCNLLTAAQPDESAKPRWEG FFHRTGGQKRSGSSPTRRLFRRESPLKPSVPSVPPTSTLLSVSSMSDCNSTRSLLRADSE ELLVCRPASPPPHLKAVPAVNPLVNTHIESFKRNPRQSLTPTHVHYTPSSSRILRRTPSD GAIKKSGPSNGLEPLPEKSALENSEDCSGVLRLPNPNLVFPPTPRRRCAPERPKT----- LDFVVRPRPSPRARCDVFRAEARSRAHRQTLSHGESPAYTSSTETPPTAEFGGDSAVLPT PMEAPTPFSPRKNENLLDQQDEVQSRDETVPLCRPEISLPKDSPLRFNPGF >M_mulatta_ENSMMUP00000016603 ------------------------------------------------------------ ---------------------------------------------------------MER RWPLGLGLVLLLCTPLPPGARTKEVTLMDTSKAQGELGW--LLDP----PKDGWSERQQI -LNGTPLYMYQDCPVQGRRDTDHWLRSNWIYRGEEASRVHVELQFTLRDCKSFPGGAGPL GCKETFNLLYMESDQDVGIQ----LRRPLFQKVTTVAADQSFTIRDLASGSMKLNVERCS LGHLTRRGLYLAF-HNPGACVAL-VSVRVFYQRCPETLNGLAQ---FPDTLPG---PAGL VEVAGTCLPHAQASPSPRPSGAPRMHCSPDGEWL-VPVGRCHCEPGYEEGGSGKGC---- ------------------------------------------------------------ ----------------------------VACPSGSYRMDMDTPHCLTCPQH--------S TAESEGATI---C----TCESGHYRAPGEGPQVACTRPP-----SAPQNLSSSA---SGT QLSLRWEPPADMGGRQDVRYSVRCSQCQGTVQDGGPCQPCGVGVH-FSPGA-RGLTTSAV HVSGLEPYANY--------TFNVEAQNGVSG-------LGSSGHASTSVSISMGHA---- -----------E----------------------------PLSGL--------------- -SLRLV-KKEPRQLELTWAGSRPRSPGGNL--SYELHVLNQ------------------- ---------------DEERYQM-----VLEPRVLLTELQP---DTTYIVRVRMLTP-LGP GPFSPDHEFRTSPPV-SRGLS-------G----------------GEIIAVIFG-LLLGA A-----LLLGILV---FRSR---------------------------------------- -------------------------RAQRQRQQRQRDRATDVDR---------------- ------------------------------------EDKLWLKPYVDLQAYEDPAQGALD FT-------------REL-DPAWLMGDTVIGEGEFGEVYRGTLRLPSQ-DCK--TVAIKT LKDTS--------PG--GQWWNFLR---EATIMGQ--FSHPHILHLEGVITKR-KPIMII TEFMENGALDAFL-REQE-------DQLVPGQLVAMLQGIA--SGMNYLS---NH---NY VHRDLAARNILVNQ--------DLCCKVSDFGLTRLL-D----D-FDGTY---------- --------ETQ-GGKIPIRWTAPEAI-AHRI--FTTASDVWSFGIVMWEVLSFGDKPYGE MS----NQE--VMKSIEDG--------YR------------------------------- ------------------------LPPP----VDCPAP-LYELMK--NCWAYDRARRPHF Q---------------------------------------------K-LQAHLEQVLANP H--------SLRTIANFDPRVTLRLPSLSGS-DGIPYRSVSEWLESIRMKRYILHFHSAG LDTMECVL---------------------------------------------------- --ELTAE----DLTQMGITLPGHQKRILCSIQGFKD------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_rubripes_ENSTRUP00000009191 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------LWTAAYD YDASGEDELSLRR--------------------------------------------GDV VEV----LSKDAAI---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SGD EGWWTGK-IHHRVGIFPSNYVTYQ------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------PAIYRLPTTTGSVG VAERVPGSP------VQI-PFSELVLEEIIGVGGFGKVYRGTW------TDQ--EVAVKA ARQD--PDED---IT--ATASSVKQ---EAKLFSM--LQHPNIIKLEGVCLEE-PNLCLV MEYARGGTLNRAL-TGRR---------IPPHILVNWAVQIA--RGMQYLH---EEAVVSI IHRDLKSSNILLLEKIENDDIGRKTLKITDFGLAREWHK--------TTK---------- ---------MS-A-AGTYSWMAPEVI-KSSL--FSKGSDIWGYGVLLWELLT-GEVPYRG ID----GLA--VAYGVAVN------K-LT------------------------------- ------------------------LPIP----STCPEP-FAKLME--ECWDQDPHVRPSF S---------------------------------------------C-ILEQLSAIEEAV M-ATMPQDSFHSMQDDWRVEIQEMFDELRTK-EKELRSREEELTRAALQQKSQEELLKRR EQQLAEREIDVLERELNILIFQLNKDKPNVKKRKGKFKRSRLKL--KD-GNRISLPSDFQ HKITVQASPSMDKRRSLHSNSSSPPSSPTLIPRLRAIQLTQDESNRTWGRSSLYRPEEFD DVKKGIKKKGRTWGPSSVQTKERPAAVERVR-----PLSDGSNPWSTSLVKSQKSVPLAA LFAEQASAGKDETVSQESPDSSSKPKQLKFPNQVYIDLPLWRDEPQSPGGAGDCGVGAGA SSTSTTPQHTPTNSLKRTSARRKTDSVLYGCGSLLASVVLGYDIREALKNPITPGDDCES PREEKEKKKKEGLFQRATRFRRSTSPPGGRSRKDEASSNHQGSAQPVNLISMSAIIECNS TKCLLQSEACLSDNGPGMVSPVVLSQHTEPVRVGSE----PVRRTQLQDNHRCHKDHNAN PKSDAGADQPQHRNTPAQEEIPQQFCGILTLWHLFPANGQPTPATQKKQDKDRAPDKVSG GEGLSRPRPVSFRAKPHAWALLRGRNKSYSLGHYSGERTAQNLSMVLSSEGCSLLDMDTE GQKRDCTVPLCRIQSSPARPSVFELEKEFLS--------------------