>H_sapiens_ENSP00000263967 -----------------------------------MPPRPSSGELWGIHLM-----PP-- ------------------------------------------------------------ ---------------------------RILVECLLPN-GM--------IVTLECLREATL ITIK-HELFKEARKYPLH------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------QLL---QDESSYIFVSVTQ---EAEREEFFDETRRLCDLRLF --QP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLKVIEPV-----GNREE----KILNREIGFAIGM-------PVCEFDMVKDPEV QDFRRNILN---VCKEAVDLRD-L---NSPHSRAMYVYPPN--VESSP-ELPKHIY-NK- LDK--GQIIVVIW------VIV-SPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLL- ---SSEQLKLCVLEYQGKYILKVCGCDEYFLE-K-YPLSQ-YK--YI-RSC-IMLGR-MP NLMLMA--KESL--YSQ-----LP----MDCF---------------------------T MP----SYSRRI----------------------------------------------ST ATPYMNG----------------------------------------------------- ------------------------------------------------------------ -----E----TSTKS--------LWVINSA-LRIKILCATYVN-------VNIR---DID KIYVRTGIYHGGEPLCD-NVNT----QRVPCSN------P-RW-NEWLN-Y-DIYIPDLP RAARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNI NLFDYT-D----------------TLVSGKMALNLWP-VP--H-G--LEDLLNPIGVTGS NPNKET----PCLE-----LEFDWFSS---VVKFPDMSV--------IEEH--------- -----------------------------------------------ANWSVSREAGFSY SHAGLSNRLARDNEL--REND----KEQLKAIS----TRDPLSEITEQEKDFLWSH-RHY CV-TIPEILPKL-LLSVKWNSRDEVA---QMY---CLVKDW-----PPIKPEQAMELLDC NYPDPMVRGFAVRCL-EKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALT--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSQRFGLLLESY CRACG-MYLKHLNRQVEAMEKLINLTDILKQE--K---KDETQ-K-V------QM----- KFLVEQMRRPD--FM----DALQGFLSPLNPAHQLGNL-R-LEECRIMSSAKRPLWLNWE NPDIM-----SELLFQNNEIIF--KNGD--DL-RQDMLTLQIIRIMENIWQNQGLDLRML PYGCLSIGDCV---GLIEVVRNSHTIMQIQC-KGGLKGA-LQFNSHTL--HQWLKDKN-K GE-------------------------IYDAAIDLFTR-SCAGYCVATFILGIGDRHNSN IMVKDDGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGAQEC--T-KTR EFERFQ---------------EMCYKAYLAIRQHANLFINLFSMMLGS-GMPELQSFDDI AYIR--KT-LAL-DK-TEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIK----------- --------------------------------------------QHALN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >M_mulatta_ENSMMUP00000006866 ----------------------------------TMPPRPSSGELWGIHLM-----PP-- ------------------------------------------------------------ ---------------------------RILVECLLPN-GM--------IVTLECLREATL ITIK-HELFKEARKYPLH------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------QLL---QDESSYIFVSVTQ---EAEREEFFDETRRLCDLRLF --QP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLKVIEPV-----GNREE----KILNREIGFAIGM-------PVCEFDMVKDPEV QDFRRNILN---VCKEAVDLRD-L---NSPHSRAMYVYPPN--VESSP-ELPKHIY-NK- LDK--GQIIVVIW------VIV-SPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLL- ---SSEQLKLCVLEYQGKYILKVCGCDEYFLE-K-YPLSQ-YK--YI-RSC-IMLGR-MP NLMLMA--KESL--YSQ-----LP----MDCF---------------------------T MP----SYSRRI----------------------------------------------ST ATPYMNG----------------------------------------------------- ------------------------------------------------------------ -----E----TSTKS--------LWVINSA-LRIKILCATYVN-------VNIR---DID KIYVRTGIYHGGEPLCD-NVNT----QRVPCSN------P-RW-NEWLN-Y-DIYIPDLP RAARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNI NLFDYT-D----------------TLVSGKMALNLWP-VP--H-G--LEDLLNPIGVTGS NPNKET----PCLE-----LEFDWFSS---VVKFPDMSV--------IEEH--------- -----------------------------------------------ANWSVSREAGFSY SHAGLSNRLARDNEL--REND----KEQLKAIS----TRDPLSEITEQEKDFLWSH-RHY CV-TIPEILPKL-LLSVKWNSRDEVA---QMY---CLVKDW-----PPIKPEQAMELLDC NYPDPMVRGFAVRCL-EKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALT--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSQRFGLLLESY CRACG-MYLKHLNRQVEAMEKLINLTDILKQE--K---KDETQ-K-V------QM----- KFLVEQMRRPD--FM----DALQGFLSPLNPAHQLGNL-R-LEECRIMSSAKRPLWLNWE NPDIM-----SELLFQNNEIIF--KNGD--DL-RQDMLTLQIIRIMENIWQNQGLDLRML PYGCLSIGDCV---GLIEVVRNSHTIMQIQC-KGGLKGA-LQFNSHTL--HQWLKDKN-K GE-------------------------IYDAAIDLFTR-SCAGYCVATFILGIGDRHNSN IMVKDDGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGAQEC--T-KTR EFERFQ---------------EMCYKAYLAIRQHANLFINLFSMMLGS-GMPELQSFDDI AYIR--KT-LAL-DK-TEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIK----------- --------------------------------------------QHALN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >P_troglodytes_ENSPTRP00000026912 -----------------------------------MPPRPSSGELWGIHLM-----PP-- ------------------------------------------------------------ ---------------------------RILVECLLPN-GM--------IVTLECLREATL ITIK-HELFKEARKYPLH------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------QLL---QDESSYIFVSVTQ---EAEREEFFDETRRLCDLRLF --QP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLKVIEPV-----GNREE----KILNREIGFAIGM-------PVCEFDMVKDPEV QDFRRNILN---VCKEAVDLRD-L---NSPHSRAMYVYPPN--VESSP-ELPKHIY-NK- LDK--GQIIVVIW------VIV-SPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLL- ---SSEQLKLCVLEYQGKYILKVCGCDEYFLE-K-YPLSQ-YK--YI-RSC-IMLGR-MP NLMLMA--KESL--YSQ-----LP----MDCF---------------------------T MP----SYSRRI----------------------------------------------ST ATPYMNG----------------------------------------------------- ------------------------------------------------------------ -----E----TSTKS--------LWVINSA-LRIKILCATYVN-------VNIR---DID KIYVRTGIYHGGEPLCD-NVNT----QRVPCSN------P-RW-NEWLN-Y-DIYIPDLP RAARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNI NLFDYT-D----------------TLVSGKMALNLWP-VP--H-G--LEDLLNPIGVTGS NPNKET----PCLE-----LEFDWFSS---VVKFPDMSV--------IEEH--------- -----------------------------------------------ANWSVSREAGFSY SHAGLSNRLARDNEL--REND----KEQLKAIS----TRDPLSEITEQEKDFLWSH-RHY CV-TIPEILPKL-LLSVKWNSRDEVA---QMY---CLVKDW-----PPIKPEQAMELLDC NYPDPMVRGFAVRCL-EKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALT--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSQRFGLLLESY CRACG-MYLKHLNRQVEAMEKLINLTDILKQE--K---KDETQ-K-V------QM----- KFLVEQMRRPD--FM----DALQGFLSPLNPAHQLGNL-R-LEECRIMSSAKRPLWLNWE NPDIM-----SELLFQNNEIIF--KNGD--DL-RQDMLTLQIIRIMENIWQNQGLDLRML PYGCLSIGDCV---GLIEVVRNSHTIMQIQC-KGGLKGA-LQFNSHTL--HQWLKDKN-K GE-------------------------IYDAAIDLFTR-SCAGYCVATFILGIGDRHNSN IMVKDDGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGAQEC--T-KTR EFERFQ---------------EMCYKAYLAIRQHANLFINLFSMMLGS-GMPELQSFDDI AYIR--KT-LAL-DK-TEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIK----------- --------------------------------------------QHALN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >E_caballus_ENSECAP00000013092 ----------------------------------TMPPRPSSGELWGIHLM-----PP-- ------------------------------------------------------------ ---------------------------RILVECLLPN-GM--------IVTLECLREATL ITIK-HELFKEARKYPLH------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------QLL---QDESSYIFVSVTQ---EAEREEFFDETRRLCDLRLF --QP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLKVIEPV-----GNREE----KILNREIGFAIGM-------PVCEFDMVKDPEV QDFRRNILN---VCKEAVDLRD-L---NSPHSRAMYVYPPN--VESSP-ELPKHIY-NK- LDK--GQIIVVIW------VIV-SPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLL- ---SSEQLKLCVLEYQGKYILKVCGCDEYFLE-K-YPLSQ-YK--YI-RSC-IMLGR-MP NLMLMA--KESL--YSQ-----LP----MDCF---------------------------T MP----SYSRRI----------------------------------------------ST ATPYMNG----------------------------------------------------- ------------------------------------------------------------ -----E----TSTKS--------LWVINSA-LRIKILCATYVN-------VNIR---DID KIYVRTGIYHGGEPLCD-NVNT----QRVPCSN------P-RW-NEWLN-Y-DIYIPDLP RAARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNI NLFDYT-D----------------TLVSGKMALNLWP-VP--H-G--LEDLLNPIGVTGS NPNKET----PCLE-----LEFDWFSS---VVKFPDMSV--------IEEH--------- -----------------------------------------------ANWSVSREAGFSY SHAGLSNRLARDNEL--REND----KEQLRAIC----TRDPLSEITEQEKDFLWSH-RHY CV-TIPEILPKL-LLSVKWNSRDEVA---QMY---CLVKDW-----PPIKPEQAMELLDC NYPDPMVRGFAVRCL-EKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALT--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSQRFGLLLESY CRACG-MYLKHLNRQVEAMEKLINLTDILKQE--K---KDETQ-K-V------QM----- KFLVEQMRRPD--FM----DALQGFLSPLNPAHQLGNL-R-LEECRIMSSAKRPLWLNWE NPDIM-----SELLFQNNEIIF--KNGD--DL-RQDMLTLQIIRIMENIWQNQGLDLRML PYGCLSIGDCV---GLIEVVRNSHTIMQIQC-KGGLKGA-LQFNSHTL--HQWLKDKN-K GE-------------------------IYDAAIDLFTR-SCAGYCVATFILGIGDRHNSN IMVKDDGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGAQEC--T-KTR EFERFQ---------------EMCYKAYLAIRQHANLFINLFSMMLGS-GMPELQSFDDI AYIR--KT-LAL-DK-TEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIK----------- --------------------------------------------QHALN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >B_taurus_ENSBTAP00000012168 ----------------------------------TMPPRPSSGELWGIHLM-----PP-- ------------------------------------------------------------ ---------------------------RILVECLLPN-GM--------IVTLECLREATL ITIK-HELFKEARKYPLH------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------QLL---QDESSYIFVSVTQ---EAEREEFFDETRRLCDLRLF --QP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLKVIEPV-----GNREE----KILNREIGFAIGM-------PVCEFDMVKDPEV QDFRRNILN---VCKEAVDLRD-L---NSPHSRAMYVY-PN--VESSP-ELPKHIY-NK- LDK--GQIIVVIW------VIV-SPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLL- ---SSEQLKLCVLEYQGKYILKVCGCDEYFLE-K-YPLSQ-YK--YI-RSC-IMLGR-MP NLMLMA--KESL--YSQ-----LP----MDCF---------------------------T MP----SYSRRI----------------------------------------------ST ATPYMNG----------------------------------------------------- ------------------------------------------------------------ -----E----TSTKS--------LWVINSA-LRIKILCATYVN-------VNIR---DID KIYVRTGIYHGGEPLCD-NVNT----QRVPCSN------P-RW-NEWLN-Y-DIYIPDLP RAARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNI NLFDYT-D----------------TLVSGKMALNLWP-VP--H-G--LEDLLNPIGVTGS NPNKET----PCLE-----LEFDWFSS---VVKFPDMSV--------IEEH--------- -----------------------------------------------ANWSVSREAGFSY SHAGLSNRLARDNEL--REND----KEQLRAIC----TRDPLSEITEQEKDFLWSH-RHY CV-TIPEILPKL-LLSVKWNSRDEVA---QMY---CLVKDW-----PPIKPEQAMELLDC NYPDPMVRGFAVRCL-EKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALT--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSQRFGLLLESY CRACG-MYLKHLNRQVEAMEKLINLTDILKQE--K---KDETQ-K-V------QM----- KFLVEQMRRPD--FM----DALQGFLSPLNPAHQLGNL-R-LEECRIMSSAKRPLWLNWE NPDIM-----SELLFQNNEIIF--KNGD--DL-RQDMLTLQIIRIMENIWQNQGLDLRML PYGCLSIGDCV---GLIEVVRNSHTIMQIQC-KGGLKGA-LQFNSHTL--HQWLKDKN-K GE-------------------------IYDAAIDLFTR-SCAGYCVATFILGIGDRHNSN IMVKDDGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGAQEC--T-KTR EFERFQ---------------EMCYKAYLAIRQHANLFINLFSMMLGS-GMPELQSFDDI AYIR--KT-LAL-DK-TEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIK----------- --------------------------------------------QHALN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >C_familiaris_ENSCAFP00000016537 ----------------------------------TMPPRPSSGELWGIHLM-----PP-- ------------------------------------------------------------ ---------------------------RILVECLLPN-GM--------IVTLECLREATL ITIK-HELFKEARKYPLH------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------QLL---QDESSYIFVSVTQ---EAEREEFFDETRRLCDLRLF --QP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLKVIEPV-----GNREE----KILNREIGFAIGM-------PVCEFDMVKDPEV QDFRRNILN---VCKEAVDLRD-L---NSPHSRAMYVYPPN--VESSP-ELPKHIY-NK- LDKVIGQIIVVIW------VIV-SPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLL- ---SSEQLKLCVLEYQGKYILKVCGCDEYFLE-K-YPLSQ-YK--YI-RSC-IMLGR-MP NLMLMA--KESL--YSQ-----LP----MDCF---------------------------T MP----SYSRRI----------------------------------------------ST ATPYMNG----------------------------------------------------- ------------------------------------------------------------ -----E----TSTKS--------LWVINSA-LRIKILCATYVN-------VNIR---DID KIYVRTGIYHGGEPLCD-NVNT----QRVPCSN------P-RW-NEWLN-Y-DIYIPDLP RAARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNI NLFDYT-D----------------TLVSGKMALNLWP-VP--H-G--LEDLLNPIGVTGS NPNKET----PCLE-----LEFDWFSS---VVKFPDMSV--------IEEH--------- -----------------------------------------------ANWSVSREAGFSY SHAGLSNRLARDNEL--REND----KEQLRAIC----TRDPLSEITEQEKDFLWSH-RHY CV-TIPEILPKL-LLSVKWNSRDEVA---QMY---CLVKDW-----PPIKPEQAMELLDC NYPDPMVRGFAVRCL-EKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALT--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSQRFGLLLESY CRACG-MYLKHLNRQVEAMEKLINLTDILKQE--K---KDETQ-K-V------QM----- KFLVEQMRRPD--FM----DALQGFLSPLNPAHQLGNL-R-LEECRIMSSAKRPLWLNWE NPDIM-----SELLFQNNEIIF--KNGD--DL-RQDMLTLQIIRIMENIWQNQGLDLRML PYGCLSIGDCV---GLIEVVRNSHTIMQIQC-KGGLKGA-LQFNSHTL--HQWLKDKN-K GE-------------------------IYDAAIDLFTR-SCAGYCVATFILGIGDRHNSN IMVKDDGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGAQEC--T-KTR EFERFQ---------------EMCYKAYLAIRQHANLFINLFSMMLGS-GMPELQSFDDI AYIR--KT-LAL-DK-TEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIK----------- --------------------------------------------QHALN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >M_musculus_ENSMUSP00000103878 -----------------------------------MPPRPSSGELWGIHLM-----PP-- ------------------------------------------------------------ ---------------------------RILVECLLPN-GM--------IVTLECLREATL VTIK-HELFREARKYPLH------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------QLL---QDETSYIFVSVTQ---EAEREEFFDETRRLCDLRLF --QP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLKVIEPV-----GNREE----KILNREIGFVIGM-------PVCEFDMVKDPEV QDFRRNILN---VCKEAVDLRD-L---NSPHSRAMYVYPPN--VESSP-ELPKHIY-NK- LDK--GQIIVVIW------VIV-SPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLL- ---SSEQLKLCVLEYQGKYILKVCGCDEYFLE-K-YPLSQ-YK--YI-RSC-IMLGR-MP NLMLMA--KESL--YSQ-----LP----IDSF---------------------------T MP----SYSRRI----------------------------------------------ST ATPYMNG----------------------------------------------------- ------------------------------------------------------------ -----E----TSTKS--------LWVINSA-LRIKILCATYVN-------VNIR---DID KIYVRTGIYHGGEPLCD-NVNT----QRVPCSN------P-RW-NEWLN-Y-DIYIPDLP RAARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNI NLFDYT-D----------------TLVSGKMALNLWP-VP--H-G--LEDLLNPIGVTGS NPNKET----PCLE-----LEFDWFSS---VVKFPDMSV--------IEEH--------- -----------------------------------------------ANWSVSREAGFSY SHTGLSNRLARDNEL--REND----KEQLRALC----TRDPLSEITEQEKDFLWSH-RHY CV-TIPEILPKL-LLSVKWNSRDEVA---QMY---CLVKDW-----PPIKPEQAMELLDC NYPDPMVRSFAVRCL-EKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALT--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSQRFGLLLESY CRACG-MYLKHLNRQVEAMEKLINLTDILKQE--K---KDETQ-K-V------QM----- KFLVEQMRQPD--FM----DALQGFLSPLNPAHQLGNL-R-LEECRIMSSAKRPLWLNWE NPDIM-----SELLFQNNEIIF--KNGD--DL-RQDMLTLQIIRIMENIWQNQGLDLRML PYGCLSIGDCV---GLIEVVRNSHTIMQIQC-KGGLKGA-LQFNSHTL--HQWLKDKN-K GE-------------------------IYDAAIDLFTR-SCAGYCVATFILGIGDRHNSN IMVKDDGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGAQEY--T-KTR EFERFQ---------------EMCYKAYLAIRQHANLFINLFSMMLGS-GMPELQSFDDI AYIR--KT-LAL-DK-TEQEALEYFTKQMNDAHHGGWTTKMDWIFHTIK----------- --------------------------------------------QHALN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >O_anatinus_ENSOANP00000021943 ----------------------------------TMPPRPSSGELWGIHLM-----PP-- ------------------------------------------------------------ ---------------------------RIIVECLLPN-GM--------IVTLECLREATL VTIK-HELFKEARKYPLH------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------QLL---QDESSYIFVSVTQ---EAEREEFFDETRRLCDLRLF --QP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLKVIEPV-----GNREE----KILNREIGFAIGM-------PVCEFDMVKDPEV QDFRRNILN---VCKEAVDLRD-V---NAPHSRALYVYPPN--VESSP-ELPKHIY-NK- LDK--GQIIVVIW------VIV-SPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLL- ---SSEQLKLCVLEYQGKYILKVCGCDEYLLE-K-YPLSQ-YK--YI-RSC-IMLGR-MP NLMLMA--KESL--YTQ-----LP----LDTF---------------------------T MP----SYSRRI----------------------------------------------ST ATPYMNG----------------------------------------------------- ------------------------------------------------------------ -----E----ASAKS--------LWVINSA-LRIKILCATYVN-------VNIR---DID KIYVRTGIYHGGEPLCD-NVNT----QRVPCSN------P-RW-NEWLM-Y-DMYIPDLP RAARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNI NLFDYT-D----------------TLVSGKMALNLWP-VP--H-G--LEDLLNPIGVTGS NPNKET----PCLE-----LEFDWFSS---PVKFPDMTV--------IEEH--------- -----------------------------------------------ANWTVSRELGFNY SHAGLSNRIARDNEL--REND----KEQLRAIC----TRDPLSEITEQEKDFLWSH-RHY CV-TTPEILPKL-LLSVKWNSRDEVA---QMY---CLVKDW-----PPIKPEQAMELLDC NYPDPRVRAFAVRCL-EKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALT--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSQRFGLLLESY CRACG-MYLKHLNRQVEAMEKLINLTDILKQE--K---KDETQ-K-V------QM----- KFLVEQMRRPD--FM----DALQGFISPLNPAHQLGNL-R-LEECRIMSSAKRPLWLNWE NPDIM-----SELLFQNNEIIF--KNGD--DL-RQDMLTLQIIRIMENIWQNQGLDLRML PYGCLSIGDCV---GLIEVVRNSHTIMQIQC-KGGLKGA-LQFNSHTL--HQWLKDKN-K GE-------------------------MYDAAIDLFTR-SCAGYCVATFILGIGDRHNSN IMVKDDGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGAQEC--T-KTR EFERFQ---------------EMCYKAYLAIRQHANLFINLFSMMLGS-GMPELQSFDDI AYIR--KT-LAL-DK-TEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIK----------- --------------------------------------------QHALN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >M_domestica_ENSMODP00000026633 -----------------------------------MPPRPSSGELWGIHLM-----PP-- ------------------------------------------------------------ ---------------------------RILVECLLPN-GM--------IVTLECLREATL VTIK-HELFKEARKYPLH------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------QLL---QDETSYIFVSVTQ---EAEREEFFDETRRLCDLRLF --QP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLKVIEPV-----GNREE----KILNREIGFAIGM-------PVCEFDMVKDPEV QDFRRNILN---VCKEAVDLRD-V---HAPHSRALYVYPPN--VESSP-ELPKHIY-NK- LDK--GQIIVVIW------VIV-SPNNDKQKYTLKINHDCVPEHVIAEAIRKKTRSMLL- ---SSEQLKLCVLEYQGKYILKVCGCDEYLLE-K-YPLSQ-YK--YI-RSC-IMLGR-MP NLMLMA--KESL--YTQ-----LP----LDTF---------------------------T MP----SYSRRI----------------------------------------------ST ATPYMNG----------------------------------------------------- ------------------------------------------------------------ -----E----ASTKS--------LWVVNSA-LRIRILCATYVN-------VNIR---DID KIYVRTGICHGGEPLCD-NVNT----QRVPCSN------P-RW-NEWLM-Y-DIYIPDLP RAARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNI NLFDYT-D----------------TLVSGKMALNLWP-VP--H-G--LEDLLNPIGVTGS NPNKET----PCLE-----LEFDWFSN---PVKFPDMAV--------IEEH--------- -----------------------------------------------ANWTVSRELGFNY SHAGLSNRIARDNEL--REND----KEQLRAIC----TRDPLSEITEQEKDFLWSH-RHY CV-SIPEILPKL-LLSVKWNSRDEVA---QMY---CLVKDW-----PPIKPEQAMELLDC NYPDPMVRAFAVRCL-EKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALT--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSQRFGLLLESY CRACG-MYLKHLNRQVEAMEKLINLTDILKQE--K---KDETQ-K-V------QM----- KFLVEQMRRPD--YM----DALQGFISPLNPAHQLGNL-R-LEECRIMSSAKRPLWLNWE NPDIM-----SELLFQNNEIIF--KNGD--DL-RQDMLTLQIIRIMENIWQNQGLDLRML PYGCLSIGDCV---GLIEVVRNSHTIMQIQC-KGGLKGA-LQFNSHTL--HQWLKDKN-K GE-------------------------IYDAAIDLFTR-SCAGYCVATFILGIGDRHNSN IMVKDDGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGAQEC--T-KTR EFERFQ---------------EMCYKAYLAIRQHANLFINLFSMMLGS-GMPELQSFDDI AYIR--KT-LAL-DK-TEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIK----------- --------------------------------------------QHALN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >G_gallus_ENSGALP00000038717 ----------------------------------KMPPRPSSGELWGIHLM-----PP-- ------------------------------------------------------------ ---------------------------RILVECLLPN-GM--------IVTLECLREATL LTIK-HELFKEARKYPLY------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------QLL---QDESSYIFVSVTQ---EAEREEFFDETRRLCDLRLF --QP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLKVIEPV-----GNREE----KILNREIGFAIGM-------PICEFDMVKDPEV QDFRRNILN---VCKEAVDLRD-A---NAPHSRALYVCPPN--VESSP-ELPKHIY-NK- LDK--GQIIVVIW------VIV-SPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLL- ---SSEQLKLCVLEYQGKYILKVCGCDEYLLE-K-YPLSQ-YK--YI-RSC-IMLGR-MP NLMLMA--KESL--YTQ-----LP----LDTF---------------------------T MP----SYSRRI----------------------------------------------ST ATPYMNG----------------------------------------------------- ------------------------------------------------------------ -----E----ATAKS--------LWTINSA-LRIRILCATYVN-------VNIR---DID KIYVRTGIYHGGEPLCD-NVNT----QRVPCSN------P-RW-NEWLS-Y-DMYIPDLP RAARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNI NMFDYT-D----------------TLVSGKMALNLWA-VP--H-G--LEDLLNPIGVTGS NPNKET----PCLE-----LEFDWFSN---PVKFPDMTV--------IEEH--------- -----------------------------------------------ANWTISRELGFNY SYAGLSNRIARDNEL--RESD----KEQLRAIC----TRDPLSEITEQEKDFLWSH-RHY CV-NTPEILPKL-LLSVKWNSRDEVA---QMY---CLVKDW-----PPIKPEQAMELLDC NYPDPMVRAFAVRCL-EKYLTDDKLSQYLIQLVQVLKYEQYLDNQLVRFLLKKALT--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSQRFGLLLESY CRACG-MYLKHLSRQVEAMEKLINLTDILKQE--K---KDETQ-K-V------QM----- KFLVEQMRRPD--FM----DALQGFISPLNPAHQLGNL-R-LEECRIMSSAKRPLWLNWE NPDIM-----SELLFQNNEIIF--KNGD--DL-RQDMLTLQIIRIMENIWQNQGLDLRML PYGCLSIGDCV---GLIEVVRSSHTIMQIQC-KGGLKGA-LQFNSHTL--HQWLKDKN-K GE-------------------------MYDAAIDLFTR-SCAGYCVATFILGIGDRHNSN IMVKDDGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGAQEC--T-KTR EFERFQ---------------EMCYKAYLAIRQHANLFINLFSMMLGS-GMPELQSFDDI AYIR--KT-LAL-DK-TEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIK----------- --------------------------------------------QHALN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >A_carolinensis_ENSACAP00000004867 -----------------------------------MPPRPSSGELWGIHLM-----PP-- ------------------------------------------------------------ ---------------------------RILVECLLPN-GM--------IVTLECLREATL LNIK-HELFKEARKYPLY------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------QLL---QDESSYIFVSVTQ---EAEREEFFDETRRLCDLRLF --QP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLKVIEPV-----GNREE----KILNREIGFAIGM-------PVCEFDLVKDPEV QDFRRNILN---VCKEAVDLRD-V---NAPHSRALYVCPPN--IESSP-ELPKHIY-SK- LDK--GQIIVVIW------VIV-SPNNDKQKYTLKINHDYVPEQVIAEAIRKKTRSMLL- ---SSEQLKLCVLEYQGKYILKVCGCDEYLLE-K-HPLSQ-YK--YI-RSC-IMLGR-MP NLMLMA--KESL--YTQ-----LP----LDTF---------------------------T MP----SYSRRI----------------------------------------------ST ATPYMNG----------------------------------------------------- ------------------------------------------------------------ -----E----SSAKS--------LWAINSN-LRIKILCATYVN-------VNIR---DID KIYVRTGIYHGGEPLCD-NVNT----QRVPCSN------P-RW-NEWLQ-Y-EMQVLDLP RAARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNI NMFDYT-D----------------TLVSGKMALNLWP-VP--H-G--LEDLLNPIGVTGS NPNKET----PCLE-----LEFDWFSS---PVKFPDMSV--------IEDH--------- -----------------------------------------------ANWTISRELGFNY SHAGLSNRLARDNEL--RESD----KEQLHAIC----TRDPLSEITEQEKDFLWSH-RHY CV-NMPEILPKL-LLSVKWNSRDEVA---QMY---CLIKDW-----PPIKPELAMELLDC NYPDPMVRSFAIRCL-EKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALT--NQ RIGHFFFWHLKSEM-H------N-----------------------KNVSQRFGLLLESY CRACG-MYLKHLSRQVEAMEKLINLTDILKQE--K---KDETQ-K-V------QM----- KFLVEQMKRPD--FM----DALQGFISPLNPAHQLGTL-R-LEECRIMSSAKRPLWLNWE NPDIM-----SELLFQNNEIIF--KNGD--DL-RQDMLTLQIIRIMENIWQNQGLDL-ML PYGCLSIGDCV---GLIEVVRNSHTIMQIQC-KGGLKGA-LQFNSHTL--HQWLKDKN-K GE-------------------------MYDPAIDLFTR-SCAGYCVATFILGIGDRHNSN IMVKDDGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGAQEC--T-KTR EFERFQ---------------EMCYKAYLAIRQHANLFINLFSMMLGS-GMPELQSFDDI AYIR--KT-LAL-DK-TEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIK----------- --------------------------------------------QHALN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >R_norvegicus_ENSRNOP00000037275 -----------------------------------IPPRPSSGELWGIHLM-----PP-- ------------------------------------------------------------ ---------------------------RILVECLLPN-GM--------IVTLECLREATL VTIK-HELFKEARKYPLH------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------QLL---QDESSYIFVSVTQ---EAEREEFFDETRRLCDLRLF --QP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLKVIEPV-----GNREE----KILNREIGFVIGM-------PVCEFDMVKDLEV QDFRRTL--------EAVGLRD-L---NSPHSRAMYVYPPN--VESSP-ELPKHIY-NK- LDK--GQIIVVIW------VIV-SPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLL- ---SSEQLKLCVLEYQGKYILKVCGCDEYFLE-K-YPLSQ-YK--YI-RSC-IMLGR-MP NLMLMA--KESL--HSQ-----LP----IDSF---------------------------T MP----SYSRRI----------------------------------------------ST ATPYMNG----------------------------------------------------- ------------------------------------------------------------ -----E----TATKS--------LWVINSA-LRIKILCATYVN-------VNIR---DID KIYVRTGIYHGGESLCD-NVNT----QRVPCSN------P-RW-NEWLN-Y-DIYIPDLP RAARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNI NLFDYT-D----------------TLVSGKMALNLWP-VP--H-G--LEDLLNPIGVTGS NPNKET----PCLE-----LEFDWFSS---VVKFPDMSV--------IEEH--------- -----------------------------------------------ANWSVSREAGFSY SHTGLSNRLARDNEL-----------------C----TRDPLSEITEQEKDFLWSH-RHY CV-TIPEILPKL-LLSVKWNSRDEVA---QMY---CLVKDW-----PPIKPEQAMELLDC NYPDPMVRSFAVRCL-EKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALT--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSQRFSLLLESY CRACG-MYLKHLNRQVEAMEKLINLTDILKQE--K---KDETQ-K-V------QM----- KFLVEQMRQPD--FM----DALQGFLSPLNPAHQLGNL-R-LEECRIMSSAKRPLWLNWE NPDIM-----SELLFQNNEIIF--KNGD--DL-RQDMLTL---RIMENIWQNQGLDLRML PYACLSIGDCV---GLIEVVRNSHTIMQIQC-KGGLKGA-LQFNRHTL--HQWLKDKN-K GK-------------------------IYDAAIDLFTW-SCAGYCVATFILGIGDRHNSN IMVKDDGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGAQEY--T-KTR EFERFQ---------------EMCYKAYLAIRQHANLFINLFSMMLGS-GMPELQSFDDI AYIR--KT-LAL-DK-TEQEALEYFTKQMNDAHHGGWTTKMDWIFHTIK----------- --------------------------------------------QHALN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >T_guttata_ENSTGUP00000011093 ----------------------------------TMPPRPSSGELWGIHLM-----PP-- ------------------------------------------------------------ ---------------------------RILVECLLPN-GM--------IVTLECLREATL LTIK-HELFKEARKYPLY------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------QLL---QDESSYIFVSVTQ---EAEREEFFDETRRLCDLRLF --QP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLKVIEPV-----GNREE----KILNREIGFAIGM-------PVCEFDMVKDPEV QDFRRNILN---VCKEAVDLRD-V---NAPHSRALYVYPPN--VESSA-ELPKHIY-NK- LDK--GQIIVVIW------VIV-SPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLL- ---SSEQLKLCVLEYQGKYILKVCGCDEYLLE-K-CPLSQ-YKKSTI-RSC-IMLGG-MP KLILMA--KES---YKQ-----LP----LDTF---------------------------T M-----SYSRRI----------------------------------------------ST ATPYMNG----------------------------------------------------- ------------------------------------------------------------ -----E----ATTKS--------LWTINSA-LRIRILCATYVN-------VNIR---DID KIYVRTGIYHGGEPLCD-NVNT----QRVPCSN------P-RW-NEWLL-Y-DMYIPDLP RAARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNI NMFDYT-D----------------TLVSGKMALNLWA-VP--H-G--LEDLLNPIGVTGS NPNKET----PCLE-----LEFDWFSN---PVKFPDMTV--------IEEH--------- -----------------------------------------------ANWTISRELGFNY SYAGQSNRIARDSEL--TESD----KEQLRAIC----TRDPLSEITEQEKDFLWRH-RHY CV-NTPEILPKL-LLSVKWNSRDEVA---QMY---CLVKDW-----PSIKPEQAMELLDC NYPDPMVRAFAVRCL-EKSLTDDKLSQYLIQLVQVLKYEQYLDNQLVRFLLKKALT--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSQRFGLLLESY CRACG-MYLKHLSRQVEAMEKLINLTDILKQE--K---KDETQ-K-V------QM----- KFLVEQMRRPD--FM----DALQGFISPLNPAHQLGNL-R-LEECRIMSSAKRPLWLNWE NPDIM-----SELLFQNNEIIF--KNGD--DL-RQDMLTLQIIRIMENIWQNQGLDLRML PYGCLSIGDCV---GLIEVVRSSHTIMQIQC-KGGLKGA-LQFNSHTL--HQWLKDKN-K GD-------------------------MYDAAIDLFTR-SCAGYCVATFILGIGDRHNSN IMVKDDGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGAQEC--T-KTR EFERFQ---------------EMCYKAYLAIRQHANLFINLFSMMLGS-GMPELQSFDDI AYIR--KT-LAL-DK-TEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIK----------- --------------------------------------------QHALN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >T_nigroviridis_ENSTNIP00000010637 ----------------------------------TMPPRPSSGELWGMHLM-----PP-- ------------------------------------------------------------ ---------------------------SILVECLLPN-GM--------ILTLECLREATL ITVK-HELFKEARKYPLY------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HLL---QEESSYIFVSVTQ---EAEREEFYDETRRLCDLRLF --QA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLKVIEPV-----GNREE----KILNREIGFAIGM-------PICEFDLVKDPEV QDFRRNILN---VCKEAVDFRD-C---NGPHSRALYVYPPN--VESSP-ELPRHIY-NK- LDK--GQIIVVIW------VIV-STSNDKQKYTLKINHDYVPEQVIAEAIRKKTRSMLL- ---SQEQLKMCVQEYQGKYILKVCGCDEYLLE-K-YPLSQ-YK--YV-RSC-IMLGR-MP NLMLMA--KDSL--YSQ-----LP----MDVF---------------------------T MP----SYARRI----------------------------------------------ST ATPYMNG----------------------------------------------------- ------------------------------------------------------------ -----E----TATKA--------LWTINGS-LRIKILCATYVN-------VNIR---DID KIYVRTGIYHGGEQLCD-NVNT----QRVPCSN------P-RW-NEWLS-Y-DMYIPDVP RAARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNI NMFDYT-H----------------TLVAGKMALNLWP-VP--H-G--LEDLLNPIGVTGS NPNKET----PCLE-----LEFEHFGC---PVKYPDMTI--------IEEH--------- -----------------------------------------------ANWNISRELGFNY CHTGLSNRLARDNPL--TDAD----NEQLRQVC----TRDPLSEITEQEKDFLWRH-RQD CL-NMPEILPKI-LLAVKWNSRDEIA---QMY---CLLKDW-----PAIRPEQAMELLDC NFPDPMIRAFAVKCL-EKYLTDDKLSQYLIQLVQVLKYEQYLDNPLARFLLKRALT--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSQRFGLLLESY CRACG-MYLKHLSRQVEAMEKLINLTDLLKQE--K---KDEAQ-K-V------QM----- KFLVEQMRRPD--YM----DALQSFTSPLNPAHQLGNL-R-LEECRMMSSAKRPLWLNWE NPDMM-----SELLFQNNEIIF--KNGD--DL-RQDMLTLQIIRIMENIWQNQGLDLRML PYGCLSIGDCV---GLIEVVRNSHTIMQIQC-KGGLKGA-LQFNSHTL--HQWLKDKN-K GE-------------------------MYDQAIDLFTR-SCAGYCVATFILGIGDRHNSN IMVKDDGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGAQEC--T-KTR EFERFQ---------------EMCYKAYLAIRQHANLFINLFSMMLGS-GMPELQSFDDI AYIR--KT-LAL-DK-SEQEALDYFMKQMNDAHHGGWTTKMDWIFHTIR----------- --------------------------------------------QHAMN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >T_rubripes_ENSTRUP00000016050 ----------------------------------TMPPRPSSGELWGMHLM-----PP-- ------------------------------------------------------------ ---------------------------SILVECLLPN-GM--------ILTLECLREATL ITVK-HELFKEARKYPLY------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HLL---QEESSYIFVSVTQ---EAEREEFYDETRRLCDLRLF --QA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLKVIEPV-----GNREE----KILNREIGFAIGM-------PICEFDLVKDPEV QDFRRNILN---VCKEAVDLRD-C---NGPHSRALYVYPPN--VESSP-ELPRHIY-NK- LDK--GQIIVVIW------VIV-SPTNDKQKYTLKINHDYVPEQVIAEAIRKKTRSMLL- ---SQEQLKMCVQEYQGKYILKVCGCDEYLLE-K-YPLSQ-YK--YV-RSC-IMLGR-MP NLMLMA--KDSL--YSQ-----LP----MDIF---------------------------T IP----SYARRI----------------------------------------------ST ATPYMNG----------------------------------------------------- ------------------------------------------------------------ -----E----TATKA--------LWTINGT-LRIKILCATYVN-------VNIR---DID KIYVRTGIYHGGEQLCD-NVNT----QRVPCSN------P-RW-NEWLS-Y-DMYIPDIP RAARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNI NMFDYT-H----------------TLVAGKMALNLWP-VP--H-G--LEDLLNPIGVTGS NPNKET----PCLE-----LEFEHFGC---PVKYPDMTI--------IEEH--------- -----------------------------------------------ANWNISRELGFNY CHTGLSSRLARDNPV--TDAD----NDQLRQVC----TRDPLSEITEQEKDFLWRH-RQD CL-NMPEILPKI-LLAVKWNSRDEIA---QMY---CLLKDW-----PAIRPEQAMELLDC NFPDPMIREFAVKCL-EKYLTDDKLSQYLIQLVQVLKYEQYLDNPLARFLLKRALT--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSQRFGLLLESY CRACG-MYLKHLSRQVEAMEKLINLTDLLKQE--K---KDEAQ-K-V------QM----- KFLVEQMRRPD--YM----DALQSFTSPLNPAHQLGNL-R-LEECRMMSSAKRPLWLNWE NPDMM-----SELLFQNNEIIF--KNGD--DL-RQDMLTLQIIRIMENIWQNQGLDLRML PYGCLSIGDCV---GLIEVVRNSHTIMQIQC-KGGLKGA-LQFNSHTL--HQWLKDKN-K GE-------------------------MYDQAIDLFTR-SCAGYCVATFILGIGDRHNSN IMVKDDGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGAQEC--T-KTR EFERFQ---------------EMCYKAYLAIRQHANLFINLFSMMLGS-GMPELQSFDDI AYIR--KT-LAL-DK-SEQEALDYFMKQMNDAHHGGWTTKMDWIFHTIR----------- --------------------------------------------QHAMN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >G_aculeatus_ENSGACP00000021206 -----------------------------------MPPRPSSGELWGMHLM-----PP-- ------------------------------------------------------------ ---------------------------SILVDCLLPN-GM--------ILTLECLREATL VTVK-HDLFKEARKYPLH------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HLL---QEESSYIFVSVTQ---EAEREEFYDETRRLCDLRLF --QA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLKVIEPV-----GNREE----KILNREIGFAIGM-------PICEFDLVKDSEV QDFRRNILN---VCKEAVDLRD-S---NGPHSRALYVYPPN--VESSV-ELPRHIY-NK- LDK--GQIIVVIW------VIV-SPSNDKQKYTLKINHDYVPEQVIAEAIRKKTRSMLL- ---SQEQLKMCVQEYQGKYILKVCGCDEYLLE-K-YPLSQ-YK--YV-RSC-IMLGR-MP NLMLMA--KDSL--YSQ-----LP----IDNF---------------------------T MP----SYARRI----------------------------------------------ST ATPYMNG----------------------------------------------------- ------------------------------------------------------------ -----E----TATKS--------LWTINGT-LRIRILCATYVN-------VNIR---DID KIYVRTGIYHGGEQLCD-NVNT----LRVPCSN------P-RW-NEWLN-Y-DMYIPDIP RAARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNI NLFDYT-H----------------TLVAGKMALNLWP-VP--H-G--LEDLLNAIGVTGS NPNKET----PCLE-----LEFDHFSC---PVKYPEMTI--------IEEH--------- -----------------------------------------------ANWNISRELGFNY CHTGLSNRLARDNPL--TDTD----NEQLRQVC----NRDPLSEITEQEKDFLWRH-RQD CV-NMPEILPKI-LLAVKWNSRDEIA---QMY---CLLKDW-----PAIKPEQAMELLDC NFPDPMIREFAVKCL-EKYLTDDKLSQYLIQLVQVLKYEQYLDNPLARFLLKRALT--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSQRFGLLLESY CRACG-MYLKHLSRQVEAMEKLINLTDLLKQE--K---KDEAQ-K-V------QM----- KFLVEQMRRPD--YM----DALQNFTSPLNPAHQLGNL-R-LEECRMMSSAKRPLWLNWE NPDMM-----SELLFQNNEIIF--KNGD--DL-RQDMLTLQIIRIMENIWQNQGLDLRML PYGCLSIGDCV---GLIEVVRNSHTIMQIQC-KGGIKGA-LQFNSHTL--HQWLKDKN-K GE-------------------------MYDQAIDLFTR-SCAGYCVATFILGIGDRHNSN IMVKDDGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGTQEC--T-KTR EFERFQ---------------EMCYKAYLAIRQHANLFINLFSMMLGS-GMPELQSFDDI AYIR--KT-LAL-DK-TEQEALDYFMKQMNDAHHGGWTTKMDWIFHTIR----------- --------------------------------------------QHAMN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >G_aculeatus_ENSGACP00000008159 -----------------------------------MPPRPSSGELWGIHLM-----PP-- ------------------------------------------------------------ ---------------------------RILVDCLLPN-GM--------ILTLECLREATL ITIK-HDLFKEARKCPLH------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------QLL---QEETSYIFVSVTQ---EAEREEFYDETRRLCDLRLF --QA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLKVIEPV-----GNREE----KILNREIGFAIGM-------PVCEFDLVKDPEV QDFRRNILN---VCKDSVELRD-A---SGPHSRALYVYPPN--VESTQ-ELPKHIY-SK- LDK--GQIIVVIW------VIV-SPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLL- ---SPEQLKMCVQEYQGKYILKVCGCDEYLLE-K-YPISQ-YK--YI-RSC-IMLGR-LP NLMLMA--KDSL--YSQ-----LP----TDNF---------------------------V MP----SYSRRI----------------------------------------------ST ATSYMNG----------------------------------------------------- ------------------------------------------------------------ -----E----AAVKS--------LWTINGT-LRIRILCATYVN-------VNIR---DID KIYVRTGIYHGGEQMCD-NVNT----QRVPCSN------P-RW-NEWLT-Y-DMYIPDIP RAARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNI NLFDYT-H----------------TLVANKMALNLWP-VP--H-G--LEDLLNPIGVTGS NPNKET----PCLE-----LEFDHFSS---SVKYPDMNA--------VEDH--------- -----------------------------------------------ANWTISRELGFSY NLSGQSNRSARDHAL--TESD----TEQMRQLS----NRDPLSEITEQEKDFLWRH-RHY CV-NIPEILPKI-LLAVKWNSRDEVA---QMY---CLLKEW-----PSIRPEQAMELLDC NYPDPMVRHFAVRCL-DKYLTDDKLSQYLIQLVQVLKYEQYLENPLARFLLKKALT--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSQRFGLLLEAY CRACG-MYLKHLSRQVEAMEKLINLTDILKQE--K---KDETQ-KEV------QM----- RFLVDQMKRPD--YM----DALQNYTSPLNPAHQLGNL-R-LDECRIMSSAKRPLWLNWE NPDIM-----SELLFQNNEIIF--KNGD--DL-RQDMLTLQIIKIMENIWQNQGLDLRML PYGCLSLGDCV---GLIEVVRSSHTIMQIQC-KGGLKGA-LQFNSNTL--HQWLKDKN-K GE-------------------------MYDMAVDLFTR-SCAGYCVATFILGIGDRHNSN IMVKDDGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGSQEC--A-KTK EFERFQ---------------EMCYKAYLAIRQHANLFINLFSMMLGS-GMPELQSFDDI AYIR--KT-LAL-EK-SEQEALDYFMKQMNDAHHGGWTTKMDWIFHTIR----------- --------------------------------------------QHALN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >O_latipes_ENSORLP00000014606 ----------------------------------KMPPRPSSGELWGLHLM-----PP-- ------------------------------------------------------------ ---------------------------RILVDCLLPN-GM--------ILTLECLREATL ITIK-HELFKEARKYPLH------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HLL---QEETCYIFVSVTQ---EAEREEFYDETRRLCDLRLF --QP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLKVIEPV-----GNREE----KILNREIGFAIGM-------PVCEFDLVKDFEV QDFRRNILN---VCKDAVELRD-A---NGPHSRALYVYPPN--VESSQ-DLPKHIY-SK- LDK--GQIIVVIW------VIV-SPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLL- ---SPEQLKMCVQEYQGKYILKVCGCDEYLLE-K-YPISQ-YK--YI-RSC-IMLGR-LP NLMLMA--KDSL--YSQ-----LP----TDSF---------------------------V MP----SYCRRI----------------------------------------------ST ATSYMNG----------------------------------------------------- ------------------------------------------------------------ -----E----AAPKS--------LWTISGG-LRIRILCATYVN-------VNIR---DID KIYVRTGIYHGGEQMCD-NVNT----QRVPCSN------P-RW-NEWLN-Y-DMYILDIP RAARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNI NLFDYN-H----------------TLVANKMALNLWP-VP--H-G--LEDLLNPIGVTGS NPNKET----PCLE-----LEFEHFSS---PVKYPDMNA--------VEEH--------- -----------------------------------------------ANWTISRELGFNY NTSGQSNRVARDHAL--TDSD----SEQLKQLS----NRDPLSEITEQEKDFLWRH-RHY CM-NIPEILPKI-LLAVKWNSRDEVA---QMY---CLLKEW-----PSIRPEQAMELLDC NYPDPMVRHFAVRCL-DKFLADDKLSQYLIQLVQVLKYEQYLDNPLARFLLKKALT--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSQRFGLLLEAY CRACG-MYLKHLSRQVEAMEKLINLTDILKQE--K---KDETQ-K-V------QM----- RFLVEQMKRPD--YM----DALQNFTSPLNPAHQLGNL-R-LEDCRIMSSAKRPLWLNWE NPDIM-----SEMLFQNNEIIF--KNGD--DL-RQDMLTLQIIKIMENIWQNQGLDLRML PYGCLSLGDCV---GLIEVVRSSHTIMQIQC-KGGLKGA-LQFNSNTL--HQWLKDKN-R GE-------------------------MYDMAVDLFTR-SCAGYCVATFILGIGDRHNSN IMVKDDGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGSQEC--T-KTK EFERFQ---------------EMCYKAYLAIRQHANLFINLFSMMLGS-GMPELQSFDDI AYIR--KT-LAL-EK-GEQEALDYFMKQMNDAHHGGWTTKMDWIFHTIR----------- --------------------------------------------QHALN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >T_nigroviridis_ENSTNIP00000009567 ----------------------------------AMPPRPSSGELWGIHLM-----PP-- ------------------------------------------------------------ ---------------------------RILVDCLLPN-GM--------ILTLECLREATL ITIK-HELFKEARKYPLH------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HLL---QEETSYIFVSVTQ---EAEREEFYDETRRLCDLRLF --QP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLKVIEPV-----GNREE----KILNREIGFAIGM-------PVCEFDLVKDPEV QDFRRNILN---VCKDSVELRD-A---SGPHSRALYVYPPN--VESSQ-ELPKHIY-SK- LDK--GQIIVVIW------VIV-SPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLL- ---SPEQLKMCVQEYQGKYILKVCGCDEYLLE-K-HPISQ-YK--YI-RSC-IMLGR-MP NLMLMA--KDSL--YSQ-----LP----TDNF---------------------------V MP----SYSRRI----------------------------------------------ST ATSYMNG----------------------------------------------------- ------------------------------------------------------------ -----E----VAAKS--------LWTINGT-LRIRILCATYVN-------VNIR---DID KIYVRTGIYHGGEQMCD-TVNT----QRVPCSN------PSRW-NEWLT-Y-DMYISDIP RAARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNV NLFDYT-H----------------TLVANKMALNLWP-VP--H-G--LEDLLNPIGVTGS NPNKET----PCLE-----MEFDHFSS---SVKYPDMNA--------VEDH--------- -----------------------------------------------ANWTISREMGLNY TLSGQSNRAARDHIL--TESD----SEQLRQLG----NRDPLSEITEQEKDFLWRH-RYY CM-KIPEILPKI-LLAVKWNSRDEVA---KMY---CLLKEW-----PSIRPEQAMELLDC NYPDPMVRHFAVRCL-DKYLTDDKLSQYLIQLVQVLKYEQYLDNPLVRFLLKKALT--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSQRFGLLLEAY CRACG-MYLKHLSRQVEAMEKLINLTDILKQE--K---KDETQ-K-V------QM----- RFLVDQMKRPD--YM----DALQNFTSPLNPAHQLGNL-R-LDECRIMSSAKRPLWLNWE NPDIM-----SELLFQNNEIIF--KNGD--DL-RQDMLTLQIIKIMENIWQSQGLDLRML PYGCLSLGDCV---GLIEVVRSSHTIMQIQC-KGGLKGA-LQFNSNTL--HQWLRDKN-K GE-------------------------MYDMAVDLFTR-SCAGYCVATFILGIGDRHNSN IMVKDDGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGSQEC--V-KTK EFERFQ---------------EMCYKAYLAIRQHANLFINLFSMMLGS-GMPELQSFDDI AYIR--KT-LAL-EK-SEQEALDYFMKQMNDAHHGGWTTKMDWIFHTIR----------- --------------------------------------------QHALN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >R_norvegicus_ENSRNOP00000055662 -----------------------------------MPPRPSSGELWGIHLM-----PP-- ------------------------------------------------------------ ---------------------------RILVECLLPN-GM--------IVTLECLREATL VTIK-HELFKEARKYPLH------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------QLL---QDESSYIFVSVTQ---EAEREEFFDETRRLCDLRLF --QP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLKVIEPV-----GNREE----KILNREIGFVIGM-------PVCEFDMVKDLEV QDFRRTL--------EAVGLRD-L---NSPHSRAMYVYPPN--VESSP-ELPKHIY-NK- LDK--GQIIVVIW------VIV-SPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLL- ---SSEQLKLCVLEYQGKYILKVCGCDEYFLE-K-YPLSQ-YK--YI-RSC-IMLGR-MP NLMLMA--KESL--HSQ-----LP----IDSF---------------------------T MP----SYSRRI----------------------------------------------ST ATPYMNG----------------------------------------------------- ------------------------------------------------------------ -----E----TATKS--------LWVINSA-LRIKILCATYVN-------VNIR---DID KIYVRTGIYHGGESLCGLTVSI----NFSGDSQ------R-MW-NEWLN-Y-DIYIPDLP RAARLCLSICSVKG----RKGAK--EVKC-LTPPKYHVPPCF-V-----KEHCPLAWGNI NLFDYT-D----------------TLVSGKMALNLWP-VP--H-G--LEDLLNPIGVTGS NPNKYN------VV-----SSNHTLRK---SKKFPEYYL--------QFDH--------- -----------------------------------------------DISSKSKNL---- -EADESNRLARDNEL--REND----KEQLRALC----TRDPLSEITEQEKDFLWSH-RHY CV-TIPEILPKL-LLSVKWNSRDEVA---QMY---CLVKDW-----PPIKPEQAMELLDC NYPDPMVRSFAVRCL-EKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALT--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSQRFGLLLESY CRACG-MYLKHLNRQVEAMEKLINLTDILKQE--K---KDETQ-K-V------QM----- KFLVEQMRQPD--FM----DALQGFLSPLNPAHQLGNL-R-LEECRIMSSAKRPLWLNWE NPDIM-----SELLFQNNEIIF--KNGD--DL-RQDMLTLQIIRIMENIWQNQGLDLRML PYGCLSIGDCV---GLIEVVRNSHTIMQIQC-KGGLKGA-LQFNSHTL--HQWLKDKN-K GE-------------------------IYDAAIDLFTR-SCAGYCVATFILGIGDRHNSN IMVKDDGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGAQEY--T-KTR EFERFQ---------------EMCYKAYLAIRQHANLFINLFSMMLGS-GMPELQSFDDI AYIR--KT-LAL-DK-TEQEALEYFTKQMNDAHHGGWTTKMDWIFHTIK----------- --------------------------------------------QHALN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >T_rubripes_ENSTRUP00000009531 -----------------------------------MPPRPSSGELWGIHLM-----PP-- ------------------------------------------------------------ ---------------------------RILVDCLLPN-GM--------ILTLECLREATL ITIK-HELFKEARKYPLH------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HLL---QEETSYIFVSVTQ---EAEREEFYDETRRLCDLRLF --QP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLKVIEPV-----GNREE----KILNREIGFAIGM-------PVCEFDLVKDPEV QDFRRNILN---VCKDSVELRD-A---SGPHSRALYVYPPN--VESSQ-ELPKHIY-SK- LDK--GQIIVVIW------VIV-SPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLL- ---SPEQLKMCVQEYQGKYILKVCGCDEYLLE-K-HPISQ-YK--YI-RSC-IMLGR-MP NLMLMA--KDSL--YSQ-----LP----TDNF---------------------------V MP----SYSRRI----------------------------------------------ST ATSYMNG----------------------------------------------------- ------------------------------------------------------------ -----E----VAAKS--------LWTINGT-LRIRILCATYVNPLVCLFFMTQR---EF- QIYVRTGIYHGGEQMCD-NVNT----QRVPCSN------P-RW-NEWLT-Y-DMYISDIP RAARLCLSICSVKG----RKGAK--EKQT-YY---IAFVVKI-C-----KEHCPLAWGNI NLFDYT-H----------------TLVANKMALNLWP-VP--H-G--LEDLLNPIGVTGS NPNKET----PCLE-----LEFDHFSS---SVKYPDILL--------QLEK--------- ----------------------------------------------------TADLG--- --------RSRDHIL--TEGD----SEQLRQLT----NRDPLSEITEQEKDFLWRN-RYY CM-NIPEILPKI-LLAVKWNSRDEVA---KMY---CLLKEW-----PSIRPEQAMELLDC NYPDPMVRHFAVRCL-DKYLTDDKLSQYLIQLVQVLKYEQYLDNPLVRFLLKKALT--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSQRFGLLLEAY CRACG-MYLKHLSRQVEAMEKLINLTDILKQE--K---KDETQ-K-V------QM----- RFLVDQMKRPD--YM----DALQNFTSPLNPAHQLGNL-R-LDECRIMSSAKRPLWLNWE NPDIM-----SELLFQNNEIIF--KNGD--DL-RQDMLTLQIIKIMENIWQNQGLDLRML PYGCLSLGDCV---GLIEVVRSSHTIMQIQC-KGGLKGA-LQFNSNTL--HQWLRDKN-K GE-------------------------MYDMAVDLFTR-SCAGYCVATFILGIGDRHNSN IMVKDDGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGSQEC--V-KTK EFERFQ---------------EMCYKAYLAIRQHANLFINLFSMMLGS-GMPELQSFDDI AYIR--KT-LAL-EK-TEQEALDYFMKQMNDAHHGGWTTKMDWIFHTIR----------- --------------------------------------------QHALN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >A_carolinensis_ENSACAP00000011831 -----------------------------------MPPRPSSGELWGLHLM-----PP-- ------------------------------------------------------------ ---------------------------RIMVDCCLPN-GM--------IVTLECLREATL LSIK-HDLFKEARKYPLF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HLL---QEESSYIFVGVTQ---EAEREEFFDESRRLCDLRLF --QP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----ILKVIEPV-----GNREE----KILNREIGFAIGM-------PICEFELVKDPEV QEFRRNILS---VCREAVETRG-S---AGPQSQALYVYPPN--VESSP-ELPKHVY-SK- -DK--GRIIVTIW------VIV-SPNNDKQKYTLKTPHDALPEQVIAEAIRKKTRSMHL- ---SPEQLRLCVQEYQGKYLLKVCGCDEYLLE-K-YPLSQ-YK--YM-RNC-ITIGR-LP HLMLMS--KESL--YSQ-----LP----ANVF---------------------------V LP----SYARR-----------------------------------------------SA TSAHVNG----------------------------------------------------- ------------------------------------------------------------ -----D----VPSKS--------LWSINSL-LRIKILCATYVN-------VNIR---DID KIYVRTGIFHGGEPLCD-NVNT----QRVPCSN------P-RW-NEWLS-Y-DIYLPDLP RAARLCVSICSVKG----RKGAK--E------------------------EHCPLAWGNV NLFDYK-D----------------TLVAGKMALNLWP-VP--H-G--LEDLLNPIGVGGS NPNKET----PCLE-----LEFTWFSH---TVKFADPTE--------IEEH--------- -----------------------------------------------ANRAMSRELGLNY CMVGLSNRLARDSSL--DESE----LEQLRNIC----NRDPLSEITEQEKDFLWRH-RHY CV-NIPETLPKL-LLSVKWNSRDEVA---QMY---CLVREW-----PLIKPELSMELLDC NFPDPVVREFALKCL-VKGLTDDKLSQYLIQLVQVLKYEQYLDNPLARFLTMKALT--NQ RIGHFYFWHLKSEM-H------S-----------------------KPVSQRFGLMLEAF CRGCG-MYLKHLNRQVEAMEKLINLTDILKQE--K---KDETQ-K-M------QM----- KFLVEQMRRPD--YM----EALQGFICPLNPVHQLGNL-R-LDECRIMSSAKRPLWLNWE NPDIM-----SELLFTNHEIIF--KNGD--DL-RQDMLTLQIIRIMESMWQNQGLDLRML PYGCLSIGDCV---GLIEVVKSSHTIMQIQC-KGGLKGA-LQFNSNAL--HHWLKDKN-K GE-------------------------GYDAAIDLFTR-SCAGYCVATFILGIGDRHNSN IMVKDDGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGVQEC--T-KTK EFERFQ---------------EMCYKAYLTIRQHANLLINLFSMMLGS-GMPELQSFDDV AYLR--KT-LAL-DK-SEQEALEYFTKQMNEAHHGGWTTKMDWIFHTIR----------- --------------------------------------------HMPLS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >O_latipes_ENSORLP00000011211 -----------------------------QVLNITMPPRPSSGELWGMHLM-----PP-- ------------------------------------------------------------ ---------------------------SIVVDCLLPN-GM--------ILSLECLREATL VTVK-HELFKEARKYPLY------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HLL---QEESSYIFVSVTQ---EAEREEFYDETRRLCDLRLF --QA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLKVIEPV-----GNREE----KILSREIGFAIGM-------PICEFDLVKDPEV QDFRRNILN---VCKEAVDLRD-N---NGPHSRALYVYPPN--VESST-DLPRHIY-NK- LDK--GDVLFFVF------F-----PNDKQKYTLKISHDCVPEQVIAEAIRKKTRSMLL- ---SQEQLKMCVQEYQGKYILKVCGCDEYLLE-K-YPLSQ-YK--YV-RSC-IMLGR-MP NLMLMS--KDSL--YSQ-----LP----SDNF---------------------------T MP----SYARRI----------------------------------------------ST ATSYMNG----------------------------------------------------- ------------------------------------------------------------ -----E----TSSKN--------LWTINGM-LKIRILCATYVN-------VNIR---DID KIYVRTGIYHGGEQLCD-NVNT----LRVPCSN------P-RW-NEWLS-Y-DMYILEIP RAARLCLSICSVKG----RKGAK--EVSCEMSNSETEKIRKCS------KEHCPLAWGNI NLFDYT-H----------------TLVAGKMALNLWP-VP--H-G--LEDLLNPIGVTGS NPNKHN----GRHL-----NYKTKFNC-----NHMSPYF--------ILEK--------- -----------------------------------------------GRKILN------- ---GDIDQLFSTSGS--KTSH----LSILRQVC----NRDPLSEITEQEKDFLWRH-RHS CI-NIPEILPKI-LLAVKWNSRDEVA---QMY---CLLKDW-----PAIKPEQAMELLDC NFPDPMIREFAVKCL-EKYLTDDKLSQYLIQLVQVLKYEQYLDNPLARFLLKKALT--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSQRFGLLLESY CRACG-MYLKHLSRQVEAMEKLINLTDLLKQE--K---KDEAQKK-V------QM----- KFLVEQMRRPD--YM----DALQSFTSPLNPAHQLGNL-R-LEECRMMSSAKRPLWLNWE NPDMM-----SELLFQNNEIIF--KNGD--DL-RQDMLTLQIIRIMENIWQNQGLDLRML PYGCLSIGDCV---GLIEVVRNSHTIMQIQC-KGGLKGA-LQFNSHTL--HQWIKDKN-K GE-------------------------MYDQAIDLFTR-SCAGYCVATFILGIGDRHNSN IMVKEDGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGTQEC--T-KTR EFERFQ---------------EMCYKAYLAIRQHANLFINLFSMMLGS-GMPELQSFDDI AYIR--KT-LAL-DK-SEQEALDYFMKQMNDAHHGGWTTKMDWIFHTIR----------- --------------------------------------------QHAMN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >G_aculeatus_ENSGACP00000001555 -----------------------------------MGPRPSSGELWGLHLM-----PP-- ------------------------------------------------------------ ---------------------------RILVDCCLPN-GM--------MVSLECLRETPL ISIK-QQLFTEARKYPLY------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HLLQNGQEESSYIFVGVTQ---EAEREEFYDETRRLCDLRLF --HP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----ILKVIEPL-----GNREE----KILNREIGFAIGM-------PVCEFEMMKDPEV QDFRRSILS---VCREAMEERE-G---GGAHSQALYVYPPN--LESSP-QLPQHIY-SK- LDK--GRLIVTIW------VIV-SPSNSKQKYTLKVSHDSLPEQLIAESIRKKSRSMHL- ---SPQQLRLCVQEYQGQYILKVCGCDEYLLE-K-YPLSQ-YK--YI-RSC-IIVGR-LP HLMLVS--KDSL--YSQ-----LP----ASGF---------------------------V TP----SYSRRT----------------------------------------------PQ PSPCPGGG---------------------------------------------------- ------------------------------------------------------------ ----DG----SPPRS--------LWAFNTL-LRVRLLCATYVN-------VNIR---DID KIYVRTGIYHGGEPLCD-NVNT----QRVPCSN------P-RW-NEWLA-Y-DIYLADIP RSARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNV NMFDYT-D----------------ILVSGKVALSLWP-VP--H-G--LEDLLNPIGVAGS NPNKET----PCVE-----LEFSWFNQ---TVVFPDEQQ--------IEEH--------- -----------------------------------------------ANWTISRELGYNY CH-GVSSRLACDSRT--SVAD----TEQLCSLC----SRDPLYELSEQEKDFLWRH-RHY CV-NMPESLPKL-LLSVKWNSRDEVS---QMY---CLLKEW-----PLMEPESALELLDC NFPDPMVREFALRCL-VQGLTDDKLSQYLLQLVQVLKYEMYLDNPLARFLIKKALT--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSRRFGLLLEAF CRACG-MYLKHLNRQVEAMDKLVNLTDTLKQE--K---KDETQ-K-T------QM----- KFLVEHMSRPD--YM----EALQGFVSPLNPVHQLGNL-R-LEECRIMSSAKRPLWLNWE NPDIM-----SELLFTNNEIIF--KNGD--DL-RQDMLTLQIIKIMENIWQNQGLDLRML PYGCLSIGDCV---GLIEVVKNSFTIMQIQC-KGGLKGA-LQFNSNTL--HHWIKDKN-R GE-------------------------AYDRAIDLFTR-SCAGYCVATFILGIGDRHNSN IMVKENGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGVQES--T-KTK EFERFQ---------------EMCYKAYLAIRQHASLFINLFSLLLGC-GMPELQSFDDI AYLR--KT-LAL-EK-SQQEALEYFTKQMNDAHHGGWSTKMDWIFHTIR----------- --------------------------------------------HMP-N----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >T_rubripes_ENSTRUP00000013971 ----------------------------------AMAPRPSSGELWGLHLM-----PP-- ------------------------------------------------------------ ---------------------------RILVDCCLPN-GM--------MVSLECLRETPL ISIK-QQLFTEARKYPLY------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HLL---QEESCYIFVGVTQ---EAEREEFYDETRRLCDLRLF --HP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----ILKVIEPL-----GNREE----KILNREIGFAIGM-------PVCEFEMLKDPEV QDFRRSILS---VCREAMEERE-G---GGAHSQALYVYPPN--VESSP-QLPQHIY-SK- LDK--GRLIVTIW------VIV-SPSNSKQKYTLKVSHDSLPEQLIAESIRKKSRSMHL- ---SPQQLRLCVQEYQGQYILKVCGCDEYLLE-K-YPLSQ-YK--YI-RSC-IIVGR-LP HLMLVS--KDSL--YSQ-----LP----ASGF---------------------------V TP----SYSRRT----------------------------------------------PQ PSPCPGGG---------------------------------------------------- ------------------------------------------------------------ ----DG----SPPRS--------LWAFNTP-LRVRLLCATYVN-------VNIR---DID KIYVRTGIYHGGEPLCD-NVNT----QRVPCSN------P-RW-NEWLT-Y-DIYLADLP RSARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNV NLFDYK-D----------------ILVSGKVALSLWP-VP--H-G--LEDLLNPIGVAGS NPNKET----PCVE-----LEFSWFNQ---TVVFPDEQQ--------IEEH--------- -----------------------------------------------ANWTISRELGYNY CH-GLSTRLACDSSV--STSD----AEQLRSLC----SKDPLYELSEQEKDFLWRH-RHY CV-NIPESLPKL-LLSVKWNSRDEVS---QPYSFICFLPEI-----LLRNRLGSHDDLEC T----TYKAQXLRCL-VQGLTDD-LSQYLLQLVQVLKYEMYLDNPLARFLIKKSLT--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSRRFGLLLEAF CRACG-MYLKHLNRQVEAMDKLVNLTDTLKQE--K---KDETQ-K-T------QM----- KFLVEHMSRPD--YM----EALQGFVSPLNPVHQLGNL-R-LEECRIMSSAKRPLWLNWE NPDIM-----SELLFTNNEIIF--KNGD--DL-RQDMLTLQIIKIMENIWQNQGLDLRML PYGCLSIGDCV---GLIEVVKNSFTIMQIQC-KGGLKGA-LQFNSNTL--HHWLKDKN-R GE-------------------------AYDRAIDLFTR-SCAGYCVATFILGIGDRHNSN IMVKENGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGVQES--T-KTK EFERFQ---------------EMCYKAYLAIRQHASLFINLFSLLLGC-GMPELQSFDDI AYLR--KT-LAL-EK-SQQEALEYFTKQMNDAHHGGWSTKMDWIFHTIR----------- --------------------------------------------HMP-N----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >T_nigroviridis_ENSTNIP00000005428 ----------------------------------AMAPRPSSGELWGLHLM-----PP-- ------------------------------------------------------------ ---------------------------RILVDCCLPNAGM--------MVSLECLRETPL VSIK-QQLFSEARKFPLH------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HLL---QEESCYIFVGVTQ---EAEREEFYDETRRLCDLRLF --HP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----ILKVIEPL-----GNREE----KILNREIGFAIGM-------PVCEFEMLKDPEV QDFRRSILS---VCREAMEERE-G---GGAHSQALYVYPPN--LESSP-QLPQHIY-SK- LDK--GRLIVTIW------VIV-SPSNSKQKYTLKVSHDSLPEQLIAESIRKKSRSMHL- ---SPQQLRLCVQEYQGQYILKVCGCDEYLLE-K-YPLSQ-YK--YI-RSC-ITVGR-LP HLMLVS--KDSL--YSQ-----LP----ASGF---------------------------V TP----SYSRRT----------------------------------------------PQ PSPCPGGG---------------------------------------------------- ------------------------------------------------------------ ----DG----SPPRS--------LWAFNTP-LRVRLLCATYVN-------VNIR---DID KIYVRTGIYHGGEPLCD-NVNT----QRVPCSN------P-RW-NEWLT-Y-DIYLADLP RSARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNV NLFDYK-D----------------ILVSGKVALSLWP-VP--H-G--LENALNPIGVA-S NPNKET----PCVE-----LEFSWFNQ---TVVFLRAEI--------EETH--------- -----------------------------------------------D----IRESGTSR C--GQSTRLACDSSV--SAGD----AEQLRSLC----SRDPLYELSEQEKDFLWRHSRHY CV-NIPESLPKL-LLSVKWNSRDEVS---QMY---CLLKEW-----SLMEPELALELLDC NFPDPMVREFALRCL-VQGLTDDKLSQYLLQLVQVLKYEMYLDNPLARFLIKKSLT--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSRRFGLLLEAF CRACG-MYLKHLNRQVEAMDKLVNLTDTLKQE--K---KDETQ-K-T------QM----- KFLVEHMSRPD--YM----DALQGFVSPLNPVHQLGNL-RQLEECRIMSSAKRP-WLNWE NPDIM-----SELLFTNNEIIF--KNGDA-DL-RQDMLTLQIIKIMENIWQNQGLDLRML PYGCLSIGDCV---GLIEVVKNSFTIMQIQC-KGGLKGA-LQFNSNTL--HHWLKDKN-R GE-------------------------AYDRAIDLFTR-SCAGYCVATFILGIGDRHNSN IMVKENGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGVQES--T-KTK EFERFQ---------------EMCYKAYLAIRQHASLFINLFSLLLGC-GMPELQSFDDI AYLR--KT-LAL-EK-SQQEALEYFTKQMNDAHHGGWSTKMDWIFHTIR----------- --------------------------------------------HMP-N----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >P_pygmaeus_ENSPPYP00000023529 -----------------------------------MPPRPSSGELWGIHLM-----PP-- ------------------------------------------------------------ ---------------------------RILVECLLPN-GM--------IVTLECLREATL ITIK-HELFKEARKYPLH------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------QLL---QDESSYIFVSVTQ---EAEREEFFDETRRLCDLRLF --QP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLKVIEPV-----GNREE----KILNREIGFAIGM-------PVCEFDMVKDPEV QDFRRNILN---VCKEAVDLRD-L---NSPHSRAMYVYPPN--VESSP-ELPKHIY-NK- LDK--GQIIVVIW------VIV-SPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLL- ---SSEQLKLCVLEYQGKYILKVCGCDEYFLE-K-YPLSQ-YK--YI-RSC-IMLGR-MP NLMLMA--KESL--YSQ-----LP----MDCF---------------------------T MP----SYSRRI----------------------------------------------ST ATPYMNG----------------------------------------------------- ------------------------------------------------------------ -----E----TSTKS--------LWVINSA-LRIKILCATYVN-------VNIR---DID KIYVRTGIYHGGEPLCD-NVNT----QRVPCSN------P-RW-NEWLN-Y-DMYIPDLP RAARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNI NLFDYT-D----------------TLVSGKMALNLWP-VP--H-G--LEDLLNPIGVTGS NPNKET----PCLE-----LEFDWFSS---VVKFPDMSV--------IEEH--------- -----------------------------------------------ANWSVSREAGFSY SHAGLSNRLARDNEL--REND----KEQLKAIS----TRDPLSEITEQEKDFLWSH-RHY CV-TIPEILPKL-LLSVKWNSRDEVA---QMY---CLVKDW-----PPIKPEQAMELLDC NYPDPMVRGFAVRCL-EKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALT--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSQRFGLLLESY CRACG-MYLKHLNRQVEAMEKLINLTDILKQE--K---KDETQ-K-V------QM----- KFLVEQMRRPD--FM----DALQGFLSPLNPAHQLGNL-R-LEECRIMSSAKRPLWLNWE NPDIM-----SELLFQNNEIIF--KNGD--DL-RQDMLTLQIIRIMENIWQNQGLDLR-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >O_cuniculus_ENSOCUP00000009163 ----------------------------------TMPPRPSSGELWGIHLM-----PP-- ------------------------------------------------------------ ---------------------------RILVECLLPN-GM--------IVTLECLREATL ITIK-HELFKEARKYPLH------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------QLL---QDESSYIFVSVTQ---EAEREEFFDETRRLCDLRLF --QP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLKVIEPV-----GNREE----KILNREIXXXXXX-------XXXXXXXXXXXXX XXXXXXXXX---XXXXXXXXXX-X---XXXXXXXXXXXXXX--XXXXX-XXXXXXX-XX- XXX--XQIIVVIW------VIV-SPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLL- ---SSEQLKLCVLEYQGKYILKVCGCDEYFLE-K-YPLSQ-YK--XX-XXX-XXXXX-XX XXXXXX--XXXX--XXX-----XX----XXXX---------------------------X XX----XXXXXX----------------------------------------------XX XXXXXXX----------------------------------------------------- ------------------------------------------------------------ -----X----XXXXX--------XXXXXXX-XXXXXXXXXXXX-------XXXX---XXX XIYVRTGIYHGGEPLCD-NVNT----QRVPCSN------P-RW-NEWLN-Y-DIYIPDLP RAARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNI NLFDYT-D----------------TLVSGKMALNLWP-VP--H-G--LEDLLNPIGVTGS NPNKET----PCLE-----LEFDWFSS---VVKFPDMSV--------IEEH--------- -----------------------------------------------ANWSVSREAGFSY SHAGLXXXXXXXXXL--REND----KEQLRAIC----TRDPLSEITEQEKDFLWSH-RHY CV-TIPEILPKL-LLSVKWNSRDEVA---QMY---CLVKDW-----PPIKPEQAMELLDC NYPDPMVRAFAVRCL-EKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALT--NQ RIGHFFFWHLXXXX-X------X-----------------------XXXXXXXXXXXXXX XXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXX--X---XXXXX-X-V------QM----- KFLVEQMRQPD--FM----DALQGFLSPLNPAHQLGNL-R-LEECRIMSSAKRPLWLNWE NPDIM-----SELLFQNNEIIF--KNGD--DL-RQDMLTLQIIRIMENIWQNQGLDLRML PYGCLSIGDCV---GLIEVVRNSHTIMQIQC-KGGLKGA-LQFNSHTL--HQWLKDKN-K GE-------------------------IYDAAIDLFTR-SCAGYCVATFILGIGDRHNSN IMVKDDGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGAQEC--T-KTR EFERFQ---------------EMCYKAYLAIRQHANLFINLFSMMLGS-GMPELQSFDDI AYIR--KT-LAL-DK-TEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIK----------- --------------------------------------------QHALN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >X_tropicalis_ENSXETP00000015756 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------DETRRLCDLRLF --QP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLKVVEPV-----GNREE----KILNREIGFAIGM-------PVCEFDMVKDSEV QDFRKNILN---VCKDSVELRD-A---NGPISRALYVYPPN--VESSS-ELPKHIE-SK- LDK--GQIIVVIW------VIV-SPNNEKQKYSLKINHDCVPEHVIAEAIRKKTRSMLL- ---SSEQLKLCVLEYQGKYILKVCGCDEYLLE-K-YPLSQ-YK--YI-RSC-IMLGR-MP NLMLMA--KDSL--YSQ-----IP----VDVF---------------------------T MP----SYSRRI----------------------------------------------ST AAPYMNG----------------------------------------------------- ------------------------------------------------------------ -----E----ASAKS--------LWAINST-LRIKILCATYVN-------VNIR---DID KIYVRTGIYHGVEPLCD-NVNT----QRVPCSN------P-RW-NEWLL-Y-DMFIPDLP RAARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNI NLFDYT-D----------------TLVSGKMALNLWP-VP--H-G--LEDLLNPIGVSGS NPNKET----PCLE-----LEFDCFSS---PVKFPDMTA--------IEDH--------- -----------------------------------------------ANKVLEREMGYNY SHSGLSNRIVRENEV--RESD----KEQLKAIS----NRDPLSEITEQEKEFLWSH-RLY CR-NIPEILPKL-LLSVKWNCRDDVS---QMY---CLLKEW-----PAIRPEQAMELLDF NYPDRIVRSFAVSCL-EKYLTDDKLSQYLIQLVQVMKYEQYLDNHLVRFLLKKALV--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSQRFGLLLESY CRACG-MYLKHLSKQVEAMEKLINLTDILKQE--K---KDETQ-K-V------QM----- KFLVEQMKRPD--FM----DALQGFTSPLNPAHQLGNL-R-LEECRIMSSAKRPLWLNWE NPDIM-----SEMLFLNNEIIF--KNGD--DL-RQDMLTLQIIRIMENIWQNQGLDLRML PYGCLSIGDCV---GLIEVVRCSHTIMQIQC-KGGLKGA-LQFNSHTL--HQWLKDKN-K GE-------------------------TYDAAIDLFTR-SCAGYCVATFILGIGDRHNSN IMVKDNGQLFHIDFG--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >T_nigroviridis_ENSTNIP00000006420 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------IV-SPSNSKQKYTLKVSHDSLPEQLIAESIRKKSRSMHL- ---SPQQLRLCVQEYQGQYILKVCGCDEYLLE-K-YPLSQ-YK--YI-RSC-ITVGR-LP HLMLVS--KDSL--YSQ-----LP----ASGF---------------------------V TP----SYSRRT----------------------------------------------PQ PSPCPGGG---------------------------------------------------- ------------------------------------------------------------ ----DG----SPPRS--------LWAFNTP-LRVRLLCATYVN-------VNIR---DID KIYVRTGIYHGGEPLCD-NVNT----QRVPCSN------P-RW-NEWLT-Y-DIYLADLP RSARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNV NLFDYK-D----------------ILVSGKVALSLWP-VP--H-G--LEDPLNPIGVAGS NPNKET----PCVE-----LEFSWFNQ---TVVFPDEQQ--------IEEH--------- -----------------------------------------------ANWTISRELGYNY CHGLQSTRLACDSSV--SAGD----AEALRSLC----SRDPLYELSEQEKDFLWRHSRHY CV-NIPESLPKL-LLSVKWNSRDEVS---QMY---CLLKEW-----SLMEPELALELLDC NFPDPMVREFALRCL-VQGLTDDKLSQYLLQLVQVLKYEMYLDNPLARFLIKKSLT--NQ RIGHFFFWHLKSEM-H------N-----------------------KTVSRRFGLLLEAF CRACG-MYLKHLNRQVEAMDKLVNLTDTLKQE--K---KDETQ-K-T------QM----- KFLVEHMSRPD--YM----DALQGFVSPLNPVHQLGNLSR-LEECRIMSSAKRPLWLNWE NPDIM-----SELLFTNNEIIF--KNGDA-DL-RQDMLTLQIIKIMENIWQNQGLDLRML PYGCLSIGDCV---GLIEVVKNSFTIMQIQC-KGGLKGA-LQFNSNTL--HHWLKDKN-R GE-------------------------AYDRAIDLFTR-SCAGYCVATFILGIGDRHNSN IMVKENGQLFHIDFGHFLDHKKKKFGYK--RERVPFVLTQDFLIVISKGVQES--T-KTK EFERFQ---------------EMCYKAYLAIRQHASLFINLFSLLLGC-GMPELQSFDDI AYLR--KT-LAL-EK-SQQEALEYFTKQMNDAHHGGWSTKMDWIFHTIR----------- --------------------------------------------HMP-N----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >G_gorilla_ENSGGOP00000009158 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------FAIGM-------PVCEFDMVKDPEV QDFRRNILN---VCKEAVDLRD-L---NSPHSRAMYVYPPN--VESSP-ELPKHIY-NK- LDK--GQIIVVIW------VIV-SPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLL- ---SSEQLKLCVLEYQGKYILKVCGCDEYFLE-K-YPLSQ-YK--YI-RSC-IMLGR-MP NLMLMA--KESL--YSQ-----LP----MDCF---------------------------T MP----SYSRRI----------------------------------------------ST ATPYMNG----------------------------------------------------- ------------------------------------------------------------ -----E----TSTKS--------LWVINSA-LRIKILCATYVN-------VNIR---DID KIYVRTGIYHGGEPLCD-NVNT----QXXXXXX------X-XW-NEWLN-Y-DIYIPDLP RAARLCLSICSVKG----RKGAK--E------------------------EHCPLAWGNI NLFDYT-D----------------TLVSGKMALNLWP-VP--H-G--LEDLLNPIGVTGS NPNKET----PCLE-----LEFDWFSS---VVKFPDMSV--------IEEH--------- -----------------------------------------------ANWSVSREAGFSY SHAGLSNRLARDNEL--REND----KEQLKAIS----TRDPLSEITEQEKDFLWSH-RHY CV-TIPEILPKL-LLSVKWNSRDEVA---QXX---XXXXXX-----XXXXXXXXXXXXXX XXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XX XXXXXXXXXXXXXX-X------X-----------------------XXXXXXXXXXXXXX XXXXX-XXXXXXXXXXXXXXXXXXXXXXXKQE--K---KDETQ-K-X------XX----- XXXXEQMRRPD--FM----DALQGFLSPLNPAHQLGNL-R-LEECRIMSSAKRPLWLNWE NPDIM-----SELLFQNNEIIF--KNGD--DLXXXXXXXXXXXXXXXXXXQNQGLDLRXX XXXXXXXXXXX---XXXXXXXXXXXXXXXXX-XXXXXXX-XXXXXXXX--XXXXXXXX-X XX-------------------------XXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXX--X-XXX XXXXXX---------------XXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXDI AYIR--KT-LAL-DK-TEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIK----------- --------------------------------------------QHALN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >C_intestinalis_ENSCINP00000002790 ----------------------------------SSTHSSASGELWGFPLM-----PN-- ------------------------------------------------------------ ---------------------------KVYVDIFLPN-GI--------FISLETSRECGL FELK-ETVWNMAKEQPLY------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------DRL---LENNAYVFVGVTK---DAETEEFYDEHRRLCDIHLF --QP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----ILKLTAAK-----GNREE----KMLKQSITQAVGV-------SIDEFVRRRNPEV DDFRRDVAS---FCKSEVEARNRC---CDPHALIAYCYPPR--VEPSP-KLPLHTT-ENL LSN--TNIVIRVWV-------V-QENSFQTHASVCVPCDTTPAMIISEVVKKKVLTFNN- ---SQSNST---KSINEHYVLKVCGLNEYLEG-N-FPICQ-YK--YI-RQC-VNRDE-LP DVMLES--VKQV--LAK-----IPP----------------------------------- ------HLPYMQ----------------------------------------------PN INKHKNNK---------------------------------------------------- ------------------------------------------------------------ ----ES----RPPIM--------SHMLTQN-FKFLVNIGIYLN-------VG-------E NLYVYANLYHGTKPLCE-GKKT----VELGGTE-----AP-KW-NQWLT-F-DIKVADIP RCAKLCVAVCGVRR----KK-----------------------------DEHWPLAWANI PLYNYT-G----------------KFIQGQHTVRLWHPPC----H--MDGMLNPIGVTGS NPMKET----PCLE-----LEFEGHRA---NVEFTQTNE--------GLIE--------- ------------------------------------------------------------ ---GDYTELAFDSPPLDDGGD----LKRLMNIV----SRDPLSPLTQDERMLLWRC-RGL CK-EIPQSLPKL-LQSVKWEDRELVK---EFY---SLLASW-----PRLPPEYAIELLDC KYPDPKVRRFATECL-DVGLTDDGVLKYLLQLVTAIKFEFYLDNSLVRFLLKRAIK--NL RIGHYLFWHLKSEM-Y------D-----------------------VQVSLQFGLLLEAY CRSCG-PYLAQLVRQTEILTKLKNVNTILQKD------DNISQ----------------- KALKEYLCKPD--YQ----EILQNNLSPLNPAYKLENL-R-NNSCEVKSSAKRPIILQWH SADPL-----AQYFQPVHGILF--KNGD--DL-RQDMLTLQVLRVMDEIWQSDDLDLCIS PYICISMGHNV---GMIEIVQNAETVMNVQK-KGGVVGS-LQLRNGTL--HQWLKDNNPG EK-------------------------QYNKAI-TFTR-SCAGYCVATLLLGIADRHNDN IMIKKNGQMFHIDFGHFLNHKKKKYGIC--RNRVPFVLPGDFLRIICRG--STTELSKTY DYKHFE---------------DLCCRAYLSIRSRANLIINLFCMMLGA-GLPELSSFDDI EYIR--AS-LAV-EK-DETQAVQYFRDCLAAAQDKQWTTKVDWVCHAVR----------- --------------------------------------------NSVRK----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >M_musculus_ENSMUSP00000035037 ---------M-------------------------PPAMADNLDIWAVDSQIASD--G-- ------------------------------------------------------------ ---------------------------AISVDFLLPT-GI--------YIQLEVPREATI SYIK-QMLWKQVHNYPMF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NLL---MDIDSYMFACVNQ---TAVYEELEDETRRLCDVRPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLKLVTRS-----CDPAE----K-LDSKIGVLIGK-------GLHEFDALKDPEV NEFRRKMRK---FSEAKIQSLV-G---LSWIDWLKHTYPPE--HEPSV-LENLED---KL YG---GKLVVA----------V-HFENSQDVFSFQVSPNLNPIKINELAIQKRLTIRGK- ---ED-------EASPCDYVLQVSGRVEYVFG-D-HPLIQ-FQ--YI-RNC-VMNRT-LP HFILVE--CCKI--KKM-----YE----QEMI---------------------------A IE----AAINRNSS--------------------------------------------NL PLPLPPK----------------------------------------------------- ------------------------------------------------------------ -----K----TRVISH-------IWDNNNP-FQITLVKGNKLN-------TEET-----V KVHVRAGLFHGTELLCK-TVVS----SEISGKN-----DH-IW-NEQLE-F-DINICDLP RMARLCFAVYAVLD----KVKTK--KSTKTINPSKYQTIRKA-G-----KVHYPVAWVNT MVFDFK-G----------------QLRSGDVILHSWSSFP--D-E--LEEMLNPMGTVQT NPYAEN---ATALH-----ITFPENKK--QPCYYPPFDK--------IIEK--------- -----------------------------------------------AA-ELA-S----- -----GDSANVSSRG--GKKF----LAVLKEIL----DRDPLSQLCENEMDLIWTL-RQD CRENFPQSLPKL-LLSIKWNKLEDVA---QLQ---ALLQIW-----PKLPPREALELLDF NYPDQYVREYAVGCL-RQ-MSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALD--NR RIGQFLFWHLRSEV-H------T-----------------------PAVSVQFGVILEAY CRGSV-GHMKVLSKQVEALNKLKTLNSLIKLN--A---VKLSR-A-K------GK----- EAMHTCLKQSA--YR----EALSDLQSPLNPCVILSEL-Y-VEKCKYMDSKMKPLWLVYS SRAFG-----EDSV----GVIF--KNGD--DL-RQDMLTLQMLRLMDLLWKEAGLDLRML PYGCLATGDRS---GLIEVVSTSETIADIQLNSSNVAAT-AAFNKDAL--LNWLKEYN-S GD-------------------------DLDRAIEEFTL-SCAGYCVASYVLGIGDRHSDN IMVKKTGQLFHIDFGHILGNFKSKFGIK--RERVPFILTYDFIHVIQQG--KT--G-NTE KFGRFR---------------QCCEDAYLILRRHGNLFITLFALMLTA-GLPELTSVKDI QYLK--DS-LAL-GK-SEEEALKQFKQKFDEALRESWTTKVNWMAHTVR----------- --------------------------------------------KDYRS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >M_musculus_ENSMUSP00000101315 ---------M-------------------------PPGVDCPMEFWTKEES------Q-- ------------------------------------------------------------ ---------------------------SVVVDFLLPT-GV--------YLNFPVSRNANL STIK-QVLWHRAQYEPLF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HML---SDPEAYVFTCVNQ---TAEQQELEDEQRRLCDIQPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLRLVARE-----GDRVK----KLINSQISLLIGK-------GLHEFDSLRDPEV NDFRTKMRQ---FCEEAAAHRQ-Q---LGWVEWLQYSFPLQ--LEPSA-RGWRAGL-LRV SN---RALLVN----------V-KFEGSEESFTFQVSTKDMPLALMACALRKKATVFRQ- ---PL-------VEQPEEYALQVNGRHEYLYG-N-YPLCH-FQ--YI-CSC-LHSGL-TP HLTMVH--SSSI--LAM-----RD----EQSN---------------------------P AP----QVQKPR----------------------------------------------AK PPPIPAK----------------------------------------------------- ------------------------------------------------------------ -----K----PSSVS--------LWSLEQP-FSIELIEGRKVN-------ADER-----M KLVVQAGLFHGNEMLCK-TVSS----SEVNVCS-----EP-VW-KQRLE-F-DISVCDLP RMARLCFALYAVVE----KAKKA--RSTK----------KKS-K-----KADCPIAWANL MLFDYK-D----------------QLKTGERCLYMWPSVP--D-E--KGELLNPAGTVRG NPNTES---AAALV-----IYLPEVAP--HPVYFPALEK--------------------- -----------------------------------------------IL-ELG-R----- -----HGERGRIT-----EEE----QLQLREIL----ERRGSGELYEHEKDLVWKM-RHE VQEHFPEALARL-LLVTKWNKHEDVAQLSQML---YLLCSW-----PELPVLSALELLDF SFPDCYVGSFAIKSL-RK-LTDDELFQYLLQLVQVLKYESYLDCELTKFLLGRALA--NR KIGHFLFWHLRSEM-H------V-----------------------PSVALRFGLIMEAY CRGST-HHMKVLMKQGEALSKLKALNDFVKVS--S---QKTTK-P-Q------TK----- EMMHMCMRQET--YM----EALSHLQSPLDPSTLLEEV-C-VEQCTFMDSKMKPLWIMYS SEEAG----SAGNV----GIIF--KNGD--DL-RQDMLTLQMIQLMDVLWKQEGLDLRMT PYGCLPTGDRT---GLIEVVLHSDTIANIQLNKSNMAAT-AAFNKDAL--LNWLKSKN-P GE-------------------------ALDRAIEEFTL-SCAGYCVATYVLGIGDRHSDN IMIRESGQLFHIDFGHFLGNFKTKFGIN--RERVPFILTYDFVHVIQQG--KT--N-NSE KFERFR---------------GYCERAYTILRRHGLLFLHLFALMRAA-GLPELSCSKDI QYLK--DS-LAL-GK-TEEEALKHFRVKFNEALRESWKTKVNWLAHNVS----------- --------------------------------------------KDNRQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >R_norvegicus_ENSRNOP00000022179 ---MCFRSIM-------------------------PPAMADTLDIWAVDSQIASD--G-- ------------------------------------------------------------ ---------------------------SISVDFLLPT-GI--------YIQLEVPREATI SYIK-QMLWKQVHNYPMF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NLL---MDIDSYMFACVNQ---TAVYEELEDETRRLCDVRPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLKLVTRS-----CDPAE----K-LDSKIGVLIGK-------GLHEFDALKDPEV NEFRRKMRK---FSEDKIQSLV-G---LSWIDWLKHTYPPE--HEPSV-LENLED---KL YG---GKLVVA----------V-HFENSQDVFSFQVSPNLNPIKINELAIQKRLTIRGK- ---EE-------EASPCDYVLQVSGRVEYVFG-D-HPLIQ-FQ--YI-RNC-VMNRT-LP HFILVE--CCKI--KKM-----YE----QEMI---------------------------A IE----AAINRNSS--------------------------------------------SL PLPLPPK----------------------------------------------------- ------------------------------------------------------------ -----K----TRVISH-------VWDNNNP-FQIVLVKGNKLN-------TEET-----V KVHVRAGLFHGTELLCK-TVVS----SEISGKN-----DH-IW-NEQLE-F-DINICDLP RMARLCFAVYAVLD----KVKTK--KSTKTINPSKYQTIRKA-G-----KVHYPVAWVNT MVFDFK-G----------------QLRSGDVILHSWSSFP--D-E--LEEMLNPMGTVQT NPYAEN---ATALH-----IKFPENKK--QPYYYPPFDK--------IIEK--------- -----------------------------------------------AA-EIA-S----- -----GDSANVSSRG--GKKF----LAVLKEIL----DRDPLSQLCENEMDLIWTL-RQD CRENFPQSLPKL-LLSIKWNKLEDVA---QLQ---ALLQIW-----PKLPPREALELLDF NYPDQYVREYAVGCL-RQ-MSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALD--NR RIGQFLFWHLRSEV-H------T-----------------------PAVSIQFGVILEAY CRGSV-GHMKVLSKQVEALNKLKTLNSLIKLN--A---MKLNR-A-K------GK----- EAMHTCLKQSA--YR----EALSDLQSPLNPCVILSEL-Y-VEKCRYMDSKMKPLWLVYS NRAFG-----EDAV----GVIF--KNGD--DL-RQDMLTLQMLRLMDLLWKEAGLDLRML PYGCLATGDRS---GLIEVVSTSETIADIQLNSSNVAAT-AAFNKDAL--LNWLKEYN-S GD-------------------------DLDRAIEEFTL-SCAGYCVASYVLGIGDRHSDN IMVKKTGQLFHIDFGHILGNFKSKFGIK--RERVPFILTYDFIHVIQQG--KT--G-NTE KFGRFR---------------QCCEDAYLILRRHGNLFITLFALMLTA-GLPELTSVKDI QYLK--DS-LAL-GK-SEEEALKQFKQKFDEALRESWTTKVNWMAHTVR----------- --------------------------------------------KDYRS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >H_sapiens_ENSP00000289153 ---MCFSFIM-------------------------PPAMADILDIWAVDSQIASD--G-- ------------------------------------------------------------ ---------------------------SIPVDFLLPT-GI--------YIQLEVPREATI SYIK-QMLWKQVHNYPMF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NLL---MDIDSYMFACVNQ---TAVYEELEDETRRLCDVRPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLKLVTRS-----CDPGE----K-LDSKIGVLIGK-------GLHEFDSLKDPEV NEFRRKMRK---FSEEKILSLV-G---LSWMDWLKQTYPPE--HEPSI-PENLED---KL YG---GKLIVA----------V-HFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGK- ---ED-------EVSPYDYVLQVSGRVEYVFG-D-HPLIQ-FQ--YI-RNC-VMNRA-LP HFILVE--CCKI--KKM-----YE----QEMI---------------------------A IE----AAINRNSS--------------------------------------------NL PLPLPPK----------------------------------------------------- ------------------------------------------------------------ -----K----TRIISH-------VWENNNP-FQIVLVKGNKLN-------TEET-----V KVHVRAGLFHGTELLCK-TIVS----SEVSGKN-----DH-IW-NEPLE-F-DINICDLP RMARLCFAVYAVLD----KVKTK--KSTKTINPSKYQTIRKA-G-----KVHYPVAWVNT MVFDFK-G----------------QLRTGDIILHSWSSFP--D-E--LEEMLNPMGTVQT NPYTEN---ATALH-----VKFPENKK--QPYYYPPFDK--------IIEK--------- -----------------------------------------------AA-EIA-S----- -----SDSANVSSRG--GKKF----LPVLKEIL----DRDPLSQLCENEMDLIWTL-RQD CREIFPQSLPKL-LLSIKWNKLEDVA---QLQ---ALLQIW-----PKLPPREALELLDF NYPDQYVREYAVGCL-RQ-MSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALG--NR RIGQFLFWHLRSEV-H------I-----------------------PAVSVQFGVILEAY CRGSV-GHMKVLSKQVEALNKLKTLNSLIKLN--A---VKLNR-A-K------GK----- EAMHTCLKQSA--YR----EALSDLQSPLNPCVILSEL-Y-VEKCKYMDSKMKPLWLVYN NKVFG-----EDSV----GVIF--KNGD--DL-RQDMLTLQMLRLMDLLWKEAGLDLRML PYGCLATGDRS---GLIEVVSTSETIADIQLNSSNVAAA-AAFNKDAL--LNWLKEYN-S GD-------------------------DLDRAIEEFTL-SCAGYCVASYVLGIGDRHSDN IMVKKTGQLFHIDFGHILGNFKSKFGIK--RERVPFILTYDFIHVIQQG--KT--G-NTE KFGRFR---------------QCCEDAYLILRRHGNLFITLFALMLTA-GLPELTSVKDI QYLK--DS-LAL-GK-SEEEALKQFKQKFDEALRESWTTKVNWMAHTVR----------- --------------------------------------------KDYRS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >G_gallus_ENSGALP00000008740 ---------M-------------------------PPAVTDSLDIWAVDSQIGAD--G-- ------------------------------------------------------------ ---------------------------SISVDFLLPT-GI--------YINLDVPRDATI SHIK-QLLWKQAHTYPLF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HLL---MEIDSYMFSCVNQ---TAVHEELEDETRRLCDVRPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLKLVTRN-----CDPGE----K-LDSKIGVLIGK-------GLHEFDALQDPEV NDFRAKMRR---ISEEKIQSLV-G---LSWMDWLKHTYPPE--QEPVV-PENFQD---KL YS---GNLVVA----------I-HFDNCQDVFSFQVSPNMNPIKLNELAIRKRLTIHGK- ---EDE------EIDPADYVLQVSGRLEYVFG-D-HPLIQ-FQ--YI-HNC-VMNRT-LP QLTLVE--CCTI--KKM-----CE----QEMI---------------------------A IE----VAINRKSS--------------------------------------------NL PLPLPPK----------------------------------------------------- ------------------------------------------------------------ -----K----TRATTS-------VWDICSP-FKIVLLKGNKLN-------TEEN-----A KVHVRAGIFHGTELLCK-TIVS----TEISGRS-----DH-AW-NEVLE-F-EINVCDLP RMARLCFAVYAVMD----KMKTK--KSTKSMNPSKYQTIRKA-G-----KVHYPVAWVNT MVFDYK-G----------------QLKNGEFVLHSWSSFP--D-E--LEEMLNPMGTVQT NPYTEN---ATALH-----IRFQEYSK--QPINYPPFDK--------ILEK--------- -----------------------------------------------AA-EIARS----- -----SDNAAMAGRG--GKKF----YIVLKEIM----ERDPLSQLCENEMDLIWTL-RYD CRENFPQSLPKL-LLSLKWNKLEDVA---QLQ---ALLQIW-----PKLLPREALELLDF NYPDQYVREYAVGCL-KQ-MSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALA--NR RIGQMLFWHLRSEV-H------I-----------------------PAVSVQFGLILEAY CRGSV-AHMKVLAKQVEALNKMKTLNSLIKLN--A---MKQSK-A-K------GK----- DAMHTCLKQNA--YR----EALSDLQSPLNPSVILSEL-H-VEKCKYMDSKMKPLWIVYN NKMFG-----GDLV----GIIF--KNGD--DL-RQDMLTLQILRLMDVLWKEAGLDLRIL PYGCLATGDHS---GLIEAVSSSETIADIQLNSSNVAAA-AAFNKDAL--LNWLKEYN-L GD-------------------------DLDRAIEEFTL-SCAGYCVATYVLGIGDRHSDN IMVRKNGQLFHIDFGHILGNFKSKFGIK--RERVPFILTYDFIHVIQQG--KT--G-NTE KFGRFR---------------QYCEEAYLILRKHGNLFITLFALMLTA-GLPELTSVKDI QYLK--DS-LAL-GK-SEEEALKQFKQKFDEALRESWTTKVNWMAHTVR----------- --------------------------------------------KDYRS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >E_caballus_ENSECAP00000005743 ---------M-------------------------PPGVDCPMEFWTKEEN------Q-- ------------------------------------------------------------ ---------------------------SVAVDFLLPT-GV--------YLNFPVSRNANL STIK-KVLWHRAQYEPLF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HML---SDPEAYVFTCVNQ---TAEQQELEDEQRRLCDIQPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLRLVARE-----GDRVK----KLINSQISLVIGK-------GLHEFDSLRDPEV NDFRTKMRQ---FCEEAAARRQ-Q---LGWEAWLQYSFPLQ--LEPLA-GNWGAST-LRF PS---RALLVN----------V-KFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQ- ---PL-------VEQPEDYTLQVNGRLEYLYG-S-YPLCR-FQ--YI-CSC-LHSGL-TP HLTMVH--SSSI--LAM-----RD----EQSN---------------------------P TP----QVQKPR----------------------------------------------TK PPPIPVK----------------------------------------------------- ------------------------------------------------------------ -----K----PSSVS--------LWSLEQP-FCVELIQGSKVN-------ADER-----M KLVVQAGLFHGNETLCK-TVSS----SEVSVCS-----EP-VW-KQRLE-F-DINVCDLP RMARLCFALYAVIE----KAKKA--RSTK----------KKS-K-----KADCPIAWANL MLFDYK-D----------------QLKTGECCLYMWPSVP--D-E--KGELLNPTGTVRN NPNTES---AAALV-----ISLPEVAP--HPVYYPALDK--------------------- -----------------------------------------------IL-ELG-R----- -----PGEHGRFT-----EEE----QLQLREIL----ERRGSGELYEHEKDLVWKM-RHE VQEHFPEALARL-LLVTKWNKHEDVA---QML---YLLCSW-----PELPVLSALELLDF SFPDRHVGSFAIKSL-RK-LTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALA--NR KIGHFLFWHLRSEM-H------V-----------------------PSVALRFGLIMEAY CRGST-HHMKVLMKQGEALSKLKALNDFVKVS--S---QKATK-P-H------TK----- ELMHLCMRQET--YL----EALSHLQSPLDPSILLAEV-C-VEQCTFMDSKMKPLWVMYS NEEAG----SDGSV----GIIF--KNGD--DL-RQDMLTLQMIQLMDVLWKQEGLDLRMT PYGCLSTGDRT---GLIEVVLHSDTIANIQLNKSNMAAT-AAFNKDAL--LNWLKSKN-P GE-------------------------ALERAIEEFTL-SCAGYCVATYVLGIGDRHSDN IMIRENGQLFHIDFGHFLGNFKTKFGIN--RERVPFILTYDFVHVIQQG--KT--N-NSE KFERFR---------------GYCERAYTILRRHGLLFLHLFALMRAA-GLPELSCSKDI QYLK--DS-LAL-GK-TEEEALKHFRVKFNEALRESWKTKVNWLAHNVS----------- --------------------------------------------KDNRQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >M_mulatta_ENSMMUP00000011365 ---MCFSFIM-------------------------PPAMADILDIWAVDSQIASD--G-- ------------------------------------------------------------ ---------------------------SIPVDFLLPT-GI--------YIQLEVPREATI SYIK-QMLWKQVHNYPMF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NLL---MDIDSYMFACVNQ---TAVYEELEDETRRLCDVRPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLKLVTRS-----CDPGE----K-LDSKIGVFFGF-------GLHEFDSLKDPEV NEFRRKMRK---FSEEKILSLV-G---LSWMDWLKQTYPPE--HEPSI-PENLED---KL YG---GKLIVA----------I-HFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGK- ---ED-------EVSPYDYVLQVSGRVQYVFG-D-HPLIQ-FQ--YI-RNC-VMNRT-LP HFILVE--CCKI--KKM-----YE----QEMI---------------------------A IE----AAINRNSS--------------------------------------------NL PLPLPPK----------------------------------------------------- ------------------------------------------------------------ -----K----TRIISH-------VWENNNP-FQIVLVKGNKLN-------TEET-----V KVHVRAGLFHGTELLCK-TIVS----SEVSGKN-----DH-IW-NEPLE-F-DINICDLP RMARLCFAVYAVLD----KVKTK--KSTKTINPSKYQTIRKA-G-----KVHYPVAWVNT MVFDFK-G----------------QLRTGDIILHSWSSFP--D-E--LEEMLNPMGTVQT NPYTEN---ATALH-----IKFPENKK--QPYYYPPFDK--------IIEK--------- -----------------------------------------------AA-EIA-S----- -----SDSANVSSRG--GKKF----LPVLKEIL----DRDPLSQLCENEMDLIWTL-RQD CREIFPQSLPKL-LLSIKWNKLEDVA---QLQ---ALLQIW-----PKLPPREALELLDF NYPDQYVREYAVGCL-RQ-MSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALG--NR RIGQFLFWHLRSEV-H------I-----------------------PAVSVQFGVILEAY CRGSV-GHMKVLSKQVEALNKLKTLNSLIKLN--A---VKLNR-A-K------GK----- EAMHTCLKQSA--YR----EALSDLQSPLNPCVILSEL-Y-VEKCKYMDSKMKPLWLVYN NKVFG-----EDSV----GVIF--KNGD--DL-RQDMLTLQMLRLMDLLWKEAGLDLRML PYGCLATGDRS---GLIEVVSTSETIADIQLNSSNVAAA-AAFNKDAL--LNWLKEYN-S GD-------------------------DLDRAIEEFTL-SCAGYCVASYVLGIGDRHSDN IMVKKTGQLFHIDFGHILGNFKSKFGIK--RERVPFILTYDFIHVIQQG--KT--G-NTE KFGRFR---------------QCCEDAYLILRRHGNLFITLFALMLTA-GLPELTSVKDI QYLK--DS-LAL-GK-SEEEALKQFKQKFDEALRESWTTKVNWMAHTVR----------- --------------------------------------------KDYRS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >A_carolinensis_ENSACAP00000003172 ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SISVDCLLPT-GI--------YISLDVPRDATI CHIK-QLLWKQAHSYPLF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HLL---MEIDSYMFSCVNQ---TAVREELEDETRRLCDVRPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLQLITRS-----CDPGE----K-LDSKIGVLIGK-------GLHEFDALQDPEV KEFRIKMRR---ISEEKMQSLV-R---LSWMDWLKHTYPPE--LEPAV-QENLQD---KL YG---GNLVVA----------V-HFDNCQDVFSFQVSPNIIPIKLNELAIRKRLTIHGR- ---EDE------EVDPSNYVLQVSGRLEYVFG-D-HPLIQ-FQ--YL-HRC-VMSRT-LP QLTLIE--CSTI--KKM-----CE----QEMI---------------------------A IE----AAINRKPS--------------------------------------------NL PLPLPPK----------------------------------------------------- ------------------------------------------------------------ -----K----SRVTQS-------VWDISQP-FKVLLVNGSKLN-------TEET-----A KVHVRAGLFHGTELLCK-PIVS----SEISGRN-----DH-LW-NEPLE-F-DINVCDLP RMARLCFVVYAVMD----KMKNK--KSAK----------KKN-S-----FFHYPVAWVNT MVFDFK-G----------------QFKTGDLVLHSWSSFP--D-E--LEEMLNPMGTVQT NPYTEN---ATSLQ-----IKFQEYSK--FPIYYPPFDK--------FLHL--------- -----------------------------------------------LF-LLV------- -----------ILIL--SVFF----YIELKEIM----ERDPLSQLCENEMDLIWTL-RYD CRENFPQSLPKL-LLSVKWNKLEDVA---QLQ---ALLQIW-----SKLPPREALELLDF NYPDQYVREYAVSCL-RQ-MSDEELAQYLLQLVQVLKYEPFLDCALSRFLLEKAMA--NR RIGQMLFWHLRSEV-H------I-----------------------PAISVQFGVILEAF CRGSI-AHMKVLSKQVEALNKMKTLNNLIKLN--A---MKQSR-A-K------GK----- EAMHTCLKQRV--YK----EALSDLQSPLNPSVLLSEL-Y-VEKCKYMDSKMKPLWIVYN NKVFG-----GDLV----VIMF--KNGD--DL-RQDMLTLQMLRLMDLLWKEAGLDLRML PYGCLATGDLS---GLIEVISASETIADIQLNSSNVAAT-AAFNKDAL--LNWLKEYN-S GD-------------------------DLDRAIEAFTL-SCAGYCVATYVLGIGDRHSDN IMVRKNGQLFHIDFGHILGNFKSKFGIK--RERVPFILTYDFIHVIQQG--KT--G-NTE KFGRFR---------------QCCEEAYLILRRHGNLFITLFALMLTA-GLPELTSVKDI QYLK--DS-LAL-GK-NDEEALKQFKQKFDEALRESWTTKVNWMAHTVR----------- --------------------------------------------KDYRS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >G_gallus_ENSGALP00000004061 ---------M-------------------------PPGIYCPMEFWSKGEN------Q-- ------------------------------------------------------------ ---------------------------NIQVDFLLPT-GI--------YLNLSVPCNASL DTIK-QVVWKHAQYEPLY------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HML---SDPEAYVFTCINQ---TAEQQELEDEQRRLCDIQPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLRLVARE-----GDRVK----KLINSQISLLIGK-------GLHEFDSVQDPEV NDFRTKMCQ---FCEERAAKRQ-Q---LSWAAWMEYNFPLQ--LEPMA-KGLGTGL-LHT PI---KNIFVN----------V-KFQSGGESFTFQISPNEFPITLMSYAVKKQATVFRH- ---ET-------MENPEDYTLQVNGKYEYLYG-N-YPLYQ-FQ--YI-RSC-LHRGL-TP HLTMVH--SSTI--IAM-----RD----EQVN---------------------------S IA----NPPKMA----------------------------------------------VK PPPLPKK----------------------------------------------------- ------------------------------------------------------------ -----K----PNYGS--------LWSLEQS-FYIELVQGSKVN-------ADER-----M KLVVQAGLFHGNEMLCK-TVSS----SEVNVCS-----EP-VW-KQRLD-F-DINICDLP RMARLCFALYAVIE----KAKKA--RSTK----------KKS-K-----KADCPIAWVNV MLFDYK-D----------------QLKTGECCLHMWSSFP--D-E--KGELLNPMGTVQC NPNTES---AAALV-----ICFPNVAS--HPVYYPSFEQ--------------------- -----------------------------------------------LL-ELG-R----- -----NGEQPRSAPE--DPEE----KLQLKEIL----ERRNHTELYEHEKDLVWKM-RYD IRDQYPQALAKL-LTITKWNKHEDVA---QMI---SLLQTW-----PELPVLNALELLDF SFPDRYVGSFAINSL-KK-LTDHELFQYLLQLVQVLKYESYLDCELTKFLLDRALS--NR KIGHFLFWHLRSEM-H------V-----------------------PAVALRFGLILEAY CRGST-HHMKVLMKQGEALSKMKALNEFVKLS--S---PKATK-P-Q------AK----- EMMHVCMKQET--YL----EALSHLQSPLNPSIILTEV-C-VDQCTFMDSKMKPLWIVFN NEETG-----GGGV----GIIF--KNGD--DL-RQDMLTLQMIQLMDVLWKQEGLDLRMT PYGCLSTGDKT---GLIEVVMHSDTIANIQLNKSNMAAT-AAFNKDAL--LNWLKSKN-P GD-------------------------ALEQAIEEFTL-SCAGYCVATYVLGIGDRHSDN IMIRETGQLFHIDFGHFLGNFKTKFGIN--RERVPFILTYDFVHVIQQG--KT--N-NSE KFERFR---------------GYCEKAYMILRRHGPLFLHLFALMKAA-GLPELTCSKDI QYLK--DS-LAL-GK-TDEEALKHFRLKFNEALRESWKTKVNWLAHNVS----------- --------------------------------------------KDNRQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >M_domestica_ENSMODP00000023181 ---MCFSFIM-------------------------PPAMADILDIWAVDSQIASD--G-- ------------------------------------------------------------ ---------------------------SIPVDFLLPT-GI--------YIQLEVPREATI SHIK-QMLWKQAHSYPMF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NLL---MEIDSYMFACVNQ---TAVYEELEDETRRLCDVRPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLKVVTRN-----CDPGE----K-LDSKIGVLIGK-------GLHEFDALEDPEV MEFRSKMRQ---FSEEKIQSLI-G---LSWMDWLKHTYPPE--QEPSI-PENLED---KL YG---GNLVVA----------V-HFENCQDVFSFQVSPNMNPIKLNELAIRKRLTIHGK- ---ED-------EVDPYDYVLQVSGRLEYVFG-D-HPLIQ-FQ--YI-RNC-VMNRT-LP KLTLVE--CCNI--KKM-----CE----QEMI---------------------------A IE----AAINRNSS--------------------------------------------NL PLPLPPK----------------------------------------------------- ------------------------------------------------------------ -----K----TRIISV-------TWGAVDD-LDI--LGGTKLN-------TEET-----V KVHVRAGLFHGTELLCK-PVVS----SEISGRN-----DH-VW-SEPLE-F-DINICDLP RMARLCFAVYAV-D----KVKTK--KSTKAINPSKYQTIRKA-G-----KVHYPVAWVNT MVFDFK-G----------------QLKSGDIILHSWSSFP--D-E--LEEMLNPMGTVQT NPYTEN---ATALH-----IKFPENKK--QPYYYPPFDK--------IIEK--------- -----------------------------------------------AA-EIA-S----- -----SDSGNVSSRG--GKKF----HVVLKEIM----ERDPLSQLCENEMDLIWTL-RQD CRENFPQSLPKL-LLSVKWNKLEDVA---QLQ---ALLQ-W-----PKLPPREALELLDF NYPDQYVREYAVGCL-KQ-MSDEELSQYLLQLVQVLKYEPFLDCALSRFLLDRALA--NR RIGQFLFWHLRSEV-H------I-----------------------PAFSVQFGVILEAY CRGSV-GYMKVLSKQVEALNKLKTLNSLIKLN--A---MKLNK-A-K------GR----- EAMHTCLKQNA--YR----EALSDLQSPLNPCVILSEL-Y-VEKCKYMDSKMKPLRIVYN NKVFG-----GDPV----GVIF--KNGD--DL-RQDMLTLQMLRLMDLLWKEAGLDLRML PYGCLATGDRS---GLIEVVSTSETIADIQLNSSNVAAT-AAFNKDAL--LNWLKEYN-S GD-------------------------DLDRAIEEFTL-SCAGYCVASYVLGIGDRHSDN IMVRKTGQLFHIDFGHILGNFKSKFGIK--RERVPFILTYDFIHVIQQG--KT--G-NTE KFGRFR---------------QCCEDAYLILRRHGNLFITLFALMLTA-GLPELTSVKDI QYLK--DS-LAL-GK-SDEEALKQFKQKFDEALRESWTTKVNWMAHTMR----------- --------------------------------------------KDYRS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >P_troglodytes_ENSPTRP00000026618 ---MCFSFIM-------------------------PPAMADILDIWAVDSQIASD--G-- ------------------------------------------------------------ ---------------------------SIPVDFLLPT-GI--------YIQLEVPREATI SYIK-QMLWKQVHNYPMF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NLL---MDIDSYMFACVNQ---TAVYEELEDETRRLCDVRPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLKLVTRS-----CDPGE----K-LDSKIGVLIGK-------GLHEFDSLKDPEV NEFRRKMRK---FSEEKILSLV-G---LSWMDWLKQTYPPE--HEPSI-PENLED---KL YG---GKLIVA----------V-HFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGK- ---ED-------EVSPYDYVLQVSGRVEYVFG-D-HPLIQ-FQ--YI-RNC-VMNRA-LP HFILVE--CCKI--KKM-----YE----QEMI---------------------------A IE----AAINRNSS--------------------------------------------NL PLPLPPK----------------------------------------------------- ------------------------------------------------------------ -----K----TRIISH-------VWENNNP-FQIVLVKGNKLN-------TEET-----V KVHVRA-LFHGTELLCK-TIVS----SEVSGKN-----DH-IW-NEPLE-F-DINICDLP RMARLCFAVYAVLD----KVKTK--KSTKTINPSKYQTIRKA-G-----KVHYPVAWVNT MVFDFK-G----------------QLRTGDIILHSWSSFP--D-E--LEEMLNPMGTVQT NPYTEN---ATALH-----VKFPENKK--QPYYYPPFDK--------IIEK--------- -----------------------------------------------AA-EIA-S----- -----SDSANVSSRG--GKKF----LPVLKEIL----DRDPLSQLCENEMDLIWTL-RQD CREIFPQSLPKL-LLSIKWNKLEDVA---QLQ---ALLQIW-----PKLPPREALELLDF NYPDQYVREYAVGCL-RQ-MSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALG--NR RIGQFLFWHLRSEV-H------I-----------------------PAVSVQFGVILEAY CRGSV-GHMKVLSKQVEALNKLKTLNSLIKLN--A---VKLNR-A-K------GK----- EAMHTCLKQSA--YR----EALSDLQSPLNPCVILSEL-Y-VEKCKYMDSKMKPLWLVYN NKVFG-----EDSV----GVIF--KNGD--DL-RQDMLTLQMLRLMDLLWKEAGLDLRML PYGCLATGDRS---GLIEVVSTSETIADIQLNSSNVAAA-AAFNKDAL--LNWLKEYN-S GD-------------------------DLDRAIEEFTL-SCAGYCVASYVLGIGDRHSDN IMVKKTGQLFHIDFGHILGNFKSKFGIK--RERVPFILTYDFIHVIQQG--KT--G-NTE KFGRFR---------------QCCEDAYLILRRHGNLFITLFALMLTA-GLPELTSVKDI QYLK--DS-LAL-GK-SEEEALKQFKQKFDEALRESWTTKVNWMAHTVR----------- --------------------------------------------KDYRS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >B_taurus_ENSBTAP00000025274 ---------M-------------------------PPGVDCPMEFWTKEEN------Q-- ------------------------------------------------------------ ---------------------------NVAVDFLLPT-GV--------YLNFPVSRNANL STIK-KVLWHRAQYEPLF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HML---SDPEAYVFTCVNQ---TAEQQELEDEQRRLCDIQPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLRLVARE-----GDRVKPPTPPLILTLTWLPRLS-------GLHEFDSLQDPEV NDFRGKMRQ---FCEEAAARRQ-Q---LGWEAWLQYSFPLQ--LEPSA-RSWGPGT-LRV PN---RVLLVN----------V-KFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQ- ---PL-------VEQPEDYTLQVNGKHEYLYG-S-YPLCQ-FQ--YI-CSC-LHSGL-TP HLTMVH--SSSI--LAM-----RD----EQSN---------------------------P AP----QVQKPR----------------------------------------------TK PPPIPMK----------------------------------------------------- ------------------------------------------------------------ -----K----PSSVS--------LWSLEQP-FYIELIQGSKVN-------ADER-----M KLVVQAGLFHGNETLCK-TVSS----SEVSVCS-----EP-VW-KQRLE-F-DINICDLP RMARLCFALYAVIE----KAKKA--RSTK----------KKS-K-----KADCPIAWANL MLFDYK-D----------------QLKTGEHCLYMWPSVP--D-E--KGELLNPCGTVRS NPNTES---AAALV-----IFLPEVAP--HPVYYPFLDK--------------------- -----------------------------------------------IL-ELG-R----- -----LGEHGRFT-----EEE----QLQLREIL----ERRGSGELYEHEKDLVWKM-RHE IQEHFPEALARL-LLVTKWNKHEDVA---QML---YLLSSW-----PELPVLSALELLDF SFPDRHVGSFAIKSL-RK-LTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALA--NR RIGHFLFWHLRSEM-H------V-----------------------PSVALRFGLIMEAY CRGST-HHMKVLMKQGEALSKLKALNDVVKVS--S---QKTTK-P-Q------TK----- ELMHLCMRQET--YL----EALSHLQSPLDPSTLLAEV-C-VEQCTFMDSKMKPLWVMYS NEEAG----SDGTV----GIIF--KNGD--DL-RQDMLTLQMIQLMDILWKQEGLDLRMT PYGCLSTGDRT---GLIEVVLHSDTIANIQLNKSNMAAT-AAFNKDAL--LNWLKSKN-P GE-------------------------ALDRAIEEFTL-SCAGYCVATYVLGIGDRHSDN IMIRENGQLFHIDFGHFLGNFKTKFGIN--RERVPFILTYDFVHVIQQG--KT--N-NSE KFERFR---------------GYCERAYTILRRHGLLFLHLFALMRAA-GLPELSCSKDI QYLK--DS-LAL-GK-TEEEALKHFRVKFNEALRESWKTKVNWLAHNVS----------- --------------------------------------------KDNRQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >T_guttata_ENSTGUP00000005489 ---MCFDSTM-------------------------PPAVTDSLDIWAVDSQIAAD--G-- ------------------------------------------------------------ ---------------------------SISVDFLLPT-GI--------YINLDVPRDATI SQIK-QLLWKQAHSYPLF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HLL---MEIDSYMFSCVNQ---TAVHEELEDETRRLCDVRPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLKLVTRN-----CDPGE----K-V-SKIGVLNSN-------SLHEFDALQDPEV NDFRAKMRR---ISEEKIQSLV-G---LSWMDWLKHTYPPE--QETVI-PESFQD---KL YS---GNLVVA----------V-HFDNCQDVFSFQVSPNMNPIKLNELAIRKRLTIHGK- ---EDE------EVDPADYVLQVSGRLEYVFG-D-HPLIQ-FQ--YI-RNC-VMSRT-LP QLTLVE--CCTI--KKM-----CE----QEMI---------------------------A IE----AAINRKSS--------------------------------------------NL PLPLPPK----------------------------------------------------- ------------------------------------------------------------ -----K----TRATTS-------VWDISNP-FKIILLKGNKLN-------TEEN-----A KVHVRAGLFHGTELLCK-TIVS----TEISGRS-----DH-VW-NEVLE-F-EINVCDLP RMARLCFAVYAVMD----KMKTK--KSTKAMNPSKYQTIRKA-G-----KVHYPVAWVNT MVFDYK-G----------------HLRNGELVLHSWSSFP--D-E--LEEMLNPMGTVQT NPYTEN---ATALH-----IRFQEYSK--QPINYPPFDK--------ILEK--------- -----------------------------------------------AA-EIARN----- -----SDNAAMAGRG--GKKF----YVVLKDIM----ERDPLSQLCENEMDLIWTL-RYD CRENFPQSLPKL-LLSLKWNKLEDVA---QLQ---ALLQIW-----PKLLPREALELLDF NYPDQYVREYAVGCL-RQ-MSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALG--NR RIGQMLFWHLRSEV-H------I-----------------------PAVSVQFGLILEAY CRGSV-AHMKVLAKQVEALNKMKTLNSLIKLN--A---MKQSK-A-K------GK----- DAMHTCLKQNA--YR----EALSDLQSPLNPSVILSEL-H-VEKCRYMDSKMKPLWIVYN NKMFG-----GDLV----GIIF--KNGD--DL-RQDMLTLQILRLMDILWKEAGLDLRIL PYGCLATGDHS---GLIEAVSSSETIADIQLNSSNVAAA-AAFNKDAL--LNWLKEYN-L GD-------------------------DLDRAIEEFTL-SCAGYCVATYVLGIGDRHSDN IMVRKNGQLFHIDFGHILGNFKSKFGIK--RERVPFILTYDFIHVIQQG--KT--G-NTE KFGRFR---------------QYCEEAYLILRKHGNLFITLFALMLTA-GLPELTSIKDI QYLK--DS-LAL-GK-SEEEALKQFKQKFDEALRESWTTKVNWMAHTVR----------- --------------------------------------------KDYRS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >B_taurus_ENSBTAP00000009083 ---MCFYFMM-------------------------PPAMADVLDIWAVDSQIASD--G-- ------------------------------------------------------------ ---------------------------SIPVDFLLPT-GI--------YIQLEVPREATI SCIKQQMLWKQVTNYPMF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NLL---MEIDSYMFACVNQ---TAVYEELEDETRRLCDVRPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLKLVTRS-----CDPGE----K-LDSKIGVLIGR-------GLHEFDALKDPEV NEFRIKMRR---FSEEKIQSLV-G---LSWMDWLKHTYPPE--LEPSI-PENLED---KL YG---GKLIVA----------V-HFENCQDVFSFQVSPNMNPIKINELAIQKRLTIHGK- ---ED-------EVSPYDYVLQVSGRVEYVFG-D-HSLIQ-FQ--YI-RNC-VMNRT-LP HFILVE--CCKI--KKL-----YE----QEMV---------------------------A IE----AAINRNSS--------------------------------------------NL PLPLPPK----------------------------------------------------- ------------------------------------------------------------ -----K----TRIISH-------VWENNNP-FQIVLVKGNKLN-------TEET-----V KVHVRAGLFHGTELLCK-TVVS----SEISGKN-----DH-IW-NEPLE-F-DINTCDLP RMTRLCFAVYAVLD----KVKTK--KSTKTMNPSKYQTIRKS-G-----KVHYPVAWVNT MVFDFK-G----------------QLRSGDIILHSWSSFP--D-E--LEEMLNPMGTVQT NPYTEN---ATALH-----IKFPENKK--QPYYYPPFDK--------IIEK--------- -----------------------------------------------AA-EIA-S----- -----SDSANVSSRG--GKKF----LAVLKEIL----DRDPLSQLCENEMDLIWTL-RQD CRENFPHALPKL-LLSIKWNKLEDVA---QLQ---ALLQIW-----PKLPPREALELLDF NYPDQYVREYAVGCL-QQ-MSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALA--NR RIGQFLFWHLRSEV-H------I-----------------------PAVSVQFGVILEAY CRGSV-GHMKALSKQVEALNKLKTLNSLIKLN--A---MKLNR-A-K------GK----- EAMHTCLKQNA--YR----EALSDLQSPLNPCVILSEL-Y-VEKCKYMDSKMKPLWLVYN NKVFG-----EDSV----GVIF--KNGD--DL-RQDMLTLQMLRLMDLLWKEAGLDLRML PYGCLATGDRS---GLIEVVSTSETIADIQLNSSNVAAA-AAFNKDAL--LNWLKEYN-S GD-------------------------DLDRAIEEFTL-SCAGYCVASYVLGIGDRHSDN IMVKKTGQLFHIDFGHILGNFKSKFGIK--RERVPFILTYDFIHVIQQG--KT--G-NTE KFGRFR---------------QCCEDAYLILRRHGNLFITLFALMLTA-GLPELTSVKDI QYLK--DS-LAL-GK-TEEEALKQFKQKFDEALRESWTTKVNWMAHTVR----------- --------------------------------------------KDYRS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >E_caballus_ENSECAP00000021883 ---MCFNFMM-------------------------PPAMADSLDIWSVDSQIVSD--G-- ------------------------------------------------------------ ---------------------------SIRVDFLLPT-GI--------YIQLDVPREAPI SYIK-QMLWKQVCDYPMF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NLL---MEIDSYMFACVNQ---TAVYEELEDETRRLCDVRPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLKLVTRS-----CDPGE----K-LDSKIGVLIGK-------GLHEFDALKDPEV NEFRVKMRK---FSEEKIQSLV-G---LSWMDWLKQTYPPE--HEPSN-LENLED---KL YG---GKLIVA----------V-HFENCQDVFSFQVSPNMNPIKINELAIQKRLTIRGK- ---ED-------EVSPCDYVLQVSGRVEYVFG-D-HPLIQ-FQ--YI-RNC-VMNRT-LP HFILVE--CCKI--KKM-----YE----QEMI---------------------------A IE----AAINRNSS--------------------------------------------NL PLPLPPK----------------------------------------------------- ------------------------------------------------------------ -----K----TRVISH-------VWENNNP-FQIVLVKGNKLN-------TEET-----V KVHVRAGLFHGTELLCK-TIVS----SEISGKN-----DH-IW-NEPLE-F-DINTCDLP RMARLCFAVYAVLD----KCFS----STDTEFYSKHSTC--------------TLAWVNT MVFDFK-G----------------QLRSGDVILHSWSSFP--D-E--LEEMLNPMGTVQT NPYTEN---ATALH-----IKFPENKK--QPYYYPPFDK--------IIEK--------- -----------------------------------------------AA-EIA-S----- -----SDSANVSSRG--GKKF----LAVLKEIL----DRDPLSQLCENEMDLIWTL-RQD CRENFPQSLPKL-LLSIKWNKLEDVA---QLQ---ALLQIW-----PKLPPREALELLDF NYPDQYVREYAVNCL-RQ-MSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALA--NR RIGQFLFWHLRSEV-H------I-----------------------PAVSVQFGVILEAY CRGSV-GHMKVLSKQVEALNKLKTLNSLIKLN--A---VKLNR-A-K------GK----- EAMHTCLKQNA--YR----EALSDLQSPLNPCVILSEL-Y-VEKCKYMDSKMKPLWLVYT NKVFG-----EDSV----GVIF--KNGD--DL-RQDMLTLQMLRLMDLLWKEAGLDLRML PYGCLATGDRS---GLIEVVSTSETIADIQLNSSNVAAA-AAFNKDAL--LNWLKEYN-S GD-------------------------DLDRAIEEFTL-SCAGYCVASYVLGIGDRHSDN IMVKKTGQLFHIDFGHILGNFKSKFGIK--RERVPFILTYDFIHVIQQG--KT--G-NTE KFGRFR---------------QCCEDAYLILRRHGNLFITLFALMLTA-GLPELTSVKDI QYLK--DS-LAL-GK-SEEEALKQFKQKFDEALRESWTTKVNWMAHTVR----------- --------------------------------------------KDYRS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >C_familiaris_ENSCAFP00000011245 ---MCFNFIM-------------------------PPAMADILDIWAVDSQLASD--G-- ------------------------------------------------------------ ---------------------------SIPVDFLLPT-GI--------YIQLEVPREATI SYIKQQILWKQVHNYPMF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NLL---MEIDSYMFACVNQ---TAVYEELEDETRRLCDVRPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLKLVTRS-----CDPGE----K-LDSKIGVLIGK-------GLHEFDALKDPEV NDFRIKMRK---FSEEKIQSLV-G---LSWMDWLKQTYPPE--HEPSI-LENLED---KL YG---GKLIVA----------V-HFENCQDVFSFQISPNMNPIKINELAIQKRLTIHGK- ---ED-------EVSPNDYVLQVSGRVEYVFG-D-HPLIQ-FQ--YI-RNC-VMNRT-LP HFMLVE--CCKI--KKM-----YE----QEMI---------------------------A IE----AAINRNAS--------------------------------------------NL PLPLPPK----------------------------------------------------- ------------------------------------------------------------ -----K----MRIISH-------VWENNNP-FQIVLVKGNKLN-------TEES-----V KVHVRAGLFHGTELLCK-TIVS----SEISGKN-----DH-IW-NEPLE-F-DINTCDLP RMARLCFAVYAVLD----KVKTK--KSTKNINPCKYQTIRKS-G-----KVHYPVAWVNT MVFDFK-G----------------QLRSGDIILHSWSSFP--D-E--LEEMLNPMGTVQT NPYTEN---ATALH-----IKFPENKK--QPYYYPPFDK--------IIEK--------- -----------------------------------------------AA-EIA-S----- -----SDSANVSSRG--GKKF----LAVLKEIL----DRDPLSQLCENEMDLIWTL-RQD CRENFPQSLPKL-LLSIKWNKLEDVA---QLQ---ALLQIW-----PKLPPREALELLDF NYPDQYVREYAVGCL-RQ-MSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALA--NR RIGQFLFWHLRSEV-H------I-----------------------PAVSVQFGVILEAY CRGSV-GHMKVLSKQVEALNKLKTLNSLIKLN--A---VKLNK-A-K------GK----- EAMHTCLKQNA--YR----EALSDLQSPLNPCVILSEL-Y-VEKCKYMDSKMKPLWLVYN NKVFG-----EDSV----GVIF--KNGD--DL-RQDMLTLQMLRLMDLLWKEAGLDLRML PYGCLATGDRS---GLIEVVSTSETIADIQLNSSNVAAA-AAFNKDAL--LNWLKEYN-S GD-------------------------DLDRAIEEFTL-SCAGYCVASYVLGIGDRHSDN IMVKKTGQLFHIDFGHILGNFKSKFGIK--RERVPFILTYDFIHVIQQG--KT--G-NTE KFGRFR---------------QCCEDAYLILRRHGNLFITLFALMLTA-GLPELTSVKDI QYLK--DS-LAL-GK-SEEEALKQFKQKFDEALRESWTTKVNWMAHTVR----------- --------------------------------------------KDYRS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >P_pygmaeus_ENSPPYP00000002213 ---------M-------------------------PPGVDCPMEFWTKEEN------Q-- ------------------------------------------------------------ ---------------------------SVVVDFLLPT-GV--------YLNFPVSRNANL STIK-QLLWHRAQYEPLF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HML---SGPEAYVFTCINQ---TAEQQELEDEQRRLCDVQPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLRLVARE-----GDRVK----KLINSQISLLIGK-------GLHEFDSLCDPEV NDFRAKMCQ---FCEEAAARRQ-Q---LGWEAWLQYSFPLQ--LEPSA-RTWGPGT-LRL PN---RALLVN----------V-KFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQ- ---PL-------VEQPEDYTLQVNGRHEYLYG-S-YPLCQ-FQ--YI-CSC-LHSGL-TP HLTMVH--SSSI--LAM-----RD----EQSN---------------------------P AP----QVQKPR----------------------------------------------AK PPPIPAK----------------------------------------------------- ------------------------------------------------------------ -----K----PSSVS--------LWSLEQP-FCIELIQGSKVN-------ADER-----M KLVVQAGLFHGNEMLCK-TVSS----SEVSVCS-----EP-VW-KQRLE-F-DINICDLP RMARLCFALYAVIE----KAKKA--RSTK----------KKS-K-----KADCPIAWANL MLFDYK-D----------------QLKTGERCLYMWPSVP--D-E--KGELLNPTGTVRS NPNMDS---AAALL-----ICLPEVAP--HPVYYPALEK--------------------- ------------------------------------------------------------ -------------------------QLQLREIL----ERRGSGELYEHEKDLVWKL-RHE VQEHFPEALARL-LLVTKWNKHEDVA---QML---YLLCSW-----PELPVLSALELLDF SFPDCHVGSFAIKSL-RK-LTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALA--NR KIGHFLFWHLRSEM-H------V-----------------------PSVALRFGLILEAY CRGST-HHMKVLMKQGEALSKLKALNDFVKLS--S---QKTPK-P-Q------TK----- ELMHLCMRQEA--YL----EALSHLQSPLDPSTLLAEV-C-VEQCTFMDSKMKPLWIMYS NEEAG----SGGSV----GIIF--KNGD--DL-RQDMLTLQMIQLMDVLWKQEGLDLRMT PYGCLPTGDRT---GLIEVVLRSDTIANIQLNKSNMAAT-AAFNKDAL--LNWLKSKN-P GE-------------------------ALDRAIEEFTL-SCAGYCVATYVLGIGDRHSDN IMIRESGQLFHIDFGHFLGNFKTKFGIN--RERVPFILTYDFVHVIQQG--KT--N-NSE KFERFR---------------GYCERAYTILRRHGLLFLHLFALMRAA-GLPELSCSKDI QYLK--DS-LAL-GK-TEEEALKHFRVKFNEALRESWKTKVNWLAHNVS----------- --------------------------------------------KDNRQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >D_rerio_ENSDARP00000017757 ---------M-------------------------PPGVYGMQEVWEMEGR------Q-- ------------------------------------------------------------ ---------------------------HVNIEFLLPT-GI--------YLNFTVACSDTI STIK-KMLWKNAKNEPLF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------SAL---SDPDAYVFTCINM---TAEREELEDEQRRLCDVRPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----ILRLVARE-----GDRVE----KLITTQINQLIGK-------GHHEFDSQKNHEL NEFRTKMRA---FCEEHAYLRQ-T---LPWDKWMEYNFPCD--LEPCS-SVTQSGK-SRS I----KKIFVN----------V-KFEGSEETFVLQQDPQDLPVVLKRNALRKKSTVFRS- ---VK-------QEKPEDYSLQVNERWEFIYG-K-YPLCQ-FK--YI-FTC-LHGGL-TP HLTMVH--YSSI--VKY-----QE----EQSG---------------------------L SS----QVSRSRAQ--------------------------------------------SK PPPLPLK----------------------------------------------------- ------------------------------------------------------------ -----R----QNTCS--------LWSIQEP-FYIYLLQGSRVN-------ADEG-----M KLVVQAGLFHGSELLCK-VVTS----NEVSVCF-----DP-VW-DQKLV-F-DISVSDLP RMSRLCFALYGVIE----KTKK---RPTK----------KKN-K-----RADCPLAWVNT MVFDYK-D----------------QLKTGEFSLSTWPSVP--D-D--KGDLLNPMGTVEK NPNIDS---TAGLL-----IRFPNIRP--HPLYYPPIEK--------------------- -----------------------------------------------LN-ELG-P----- -----NGEKVIAT-----KEE----HQKLKEIV----DNKNSTEFFEDEKELLWKL-REE LRLKYPESLPKL-LLITKWNKHEDVA---QMV---GLLQKW-----PELPALHALELLDY SFPDPHVRFFTIRCL-RK-LPDDKLFQYLLQLVQVLKYESYLDCDLTSFLLERALA--NK KIGHFLFWHLRSEM-H------V-----------------------PSVSLRFGLILEAY CRGSI-FHIKSLMKQNEALNKMKALNDFVKSA--S---QKATR-I-Q------TT----- EDMKVCIKQET--YM----EALSDVVSPLSPSIILCEL-C-ADKCKFMDSKMKPLWLMYK SKY--------DSV----GIIF--KNGD--DL-RQDMLTLQMIQIMDILWKTEGLDLRMQ PYGCLSTGNKT---GLIEVVKNSDTIANIQRNNSNSAAT-AAFNKDAL--LNWLKSKN-P GD-------------------------KLDQAIEEFTL-SCAGYCVATYVLGIGDRHSDN IMIRESGQLFHIDFGHFLGNFKSKFGIN--RERVPFILTYDFVHVIQEG--RT--N-NSE KFERFR---------------VCCEQAYKILCRNGTLFVNLFALMKAA-GLPELNSSKDI QYLK--DS-LAL-GK-SEEEALKNFKVKFNEALRESWKTKVNWMMHTFA----------- --------------------------------------------KDNR------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >T_nigroviridis_ENSTNIP00000017338 LRWRAVLLAM-------------------------PPAMTDLLDIWATHTPLAGHAPD-- ------------------------------------------------------------ ---------------------------QITVDFLLPT-GI--------YIQFDVPREATI QEIK-QLLWKEAHSFPMF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------SKL---GEMESHMFECVNQ---AAVHEELEDETRRLCDIRPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLKLVTRN-----CGRAE----RLLDSKIGVLIGK-------GLHELSAINDQEV KDFRCKMAR---ISEERMRKIE-R---MTYAEWLQASYSPQ--LELTA-DPAVMEG--ND RP---ADLKVI----------I-HFDQSQDSASLKISSTCSPKDLIAQAVRKWLTTHGP- ---EE-------ETLKGQYVLRVSHCLEFLCG-D-HPLIQ-HKQ-YI-RTC-LQAKE-PP HVTLIH--NNTV--RAM-----FN----REIS---------------------------A IE----AALTPKSS--------------------------------------------NL PLPLPPK----------------------------------------------------- ------------------------------------------------------------ -----K----RAPT----QVQTCVWDVSSP-FRIVLVNASKVN-------AEET-----A KVQVRAGLFHGTELLCK-PAVS----SESSGRS-----DH-A----TLE-F-ELPVCDLP RMTRLCFAIYAVMD----KVKKQ--KSTKNTHINKYQTIRKA-G-----KVHYPIAWVNT MVFDYK-G----------------QLKTGDIILHCWSSFP--D-E--LEEMLNPIGTVQT NPYTEN---ATALH-----ISFPEFSS--HPIIFPPFDK--------ILEK--------- -----------------------------------------------AA-EIV-G----- -----ASDYASMGRG--GKKF----HIELKEIM----ERDALSQLCENEKDLIWTL-RCD CRENFPQSLPKL-LLSVKWSKHEDMA---QLQ---ALLQIW-----PRLSPRDALELLDF NYPDQYVREYAVNCL-RD-MSNDELSQYLLQLVQVLRYEPYYDCALTHFLLERAQS--SR KIGHFLFWHLRSEI-H------M-----------------------PAVSVQFALILEAY CRGSI-PHIEVLKKQVEALNKLKAVNELIKLG--T---IKNAR-S-KTKEAMLTK----- EAMMTCLRQSG--FS----ETLSDLHSPLNPNILLSGI-N-VEKCRYMDSKMKPLWIVYN NKLLL-----GDML----GIIF--KNGD--DL-RQDMLTLQILRLMDTLWKEANLDLRIV PYGCLATGDRA---GLIEVVSSADTIANIQLTSSNMAAA-AAFNKDAL--LNWLKERN-S GD-------------------------ALERAIEEFTL-SCAGYCVATYVLGIGDRHSDN IMVRSNGQLFHIDFGHILGNFKSKFGIK--RERVPFILTHDFIHVIQQG--KT--G-QAE KFGSFR---------------QYCEKAYLILRKNGNLFITLFALMLTA-GLPELTSVKDI QYLK--DS-LAL-GK-SDDEALKQFRQKFDEALRESWTTKVNWMAHNVA----------- --------------------------------------------KDNRS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >O_latipes_ENSORLP00000006834 -----VAITM-------------------------HPGIYGMLEEWE-DGD------Q-- ------------------------------------------------------------ ---------------------------EINMDFLLPT-GI--------FLKFPVSRNDTI KHIK-EMVWRNARSEALF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------SGL---GDPDGYVFTCINQ---TAEREELEEEFRRIRDVKPF --MC-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLRLVARE-----GNRQE----KLTNTQITQLIGK-------GLHEFETQKNHEV NEFRTKMRT---FCEEKALERQ-Y---LPWQRWLEYSFPCD--LEPCR-TPSGFGS-VKM KS---SKIFIN----------V-KFEASDESFMLQQDCHDLPVALMKSALKKKATVFRS- ---L--------RQEPEDYILQVNGRWDFIYG-K-HPLCQ-FK--YI-FSC-LRNGQ-NP QLTMVH--HSTV--SRF-----QE----EQSR---------------------------M CN----QMFKSRSL--------------------------------------------SR PPPLPLK----------------------------------------------------- ------------------------------------------------------------ -----R----QNTSS--------LWSINEP-FYIQLLQGSRVN-------ADEG-----M KLVVQAGLFHGSELLCK-VVTS----LDVTVCS-----EP-LW-DQRLE-F-DINVCDLP RMSRLCFALYAVIE----KTKKP--KSTKIISVS-----KKQ-SFPTCFHQDCPIAWVNT MVFDYK-D----------------QLKTGEFLLSMWPSVP--D-D--KSDLLNPMGTVEK NPNVDS---AAGLL-----IRFPNIRP--HPLYYPSLEK--------------------- -----------------------------------------------II-DFE-K----- -----NGDVACTH-----KEEITFQHLKLKEIM----DNKHYTEFFEDEKDLLWKL-RTE IREHYPENLSKL-LLVTKWNKREDVV---QMV---SLLKKW-----PDLPAIHALELLDY SFPDPAVRSFTVRCL-RK-LSDDELLQYLIQLVQVLKYESYLDCDLTTFLLERALS--NR RIGHFLFWHLRSEI-H------V-----------------------ASVSLRFGLILEAY CRGNI-HHIKILNKQNEALAKMRALSDFVKSG--S---QKMTV----------------- EDLKLCIRQET--YM----EALSDLLSPLNPSIILTEI-C-ADKCRFMDSKMKPLWLMYK NPSTP-----GDMV----GIIF--KNGD--DL-RQDMLTLQMIQLMENMWKKEGLDLRMI PYGCLSTGNKM---GLIEVVKNSDTIANIQLNSSNSAAT-AAFNKDAL--LNWLKSKN-P GD-------------------------KLEQAIEEFTL-SCAGYCVATYVLGIGDRHNDN IMIRETGQLFHIDFGHFLGNFKRKLGIN--RERVPFILTYDFVHVIQQG--RT--N-NSE KFERFR---------------EYCEQAYKILCRNGMLFVNLFAMMKAA-GLPELTCFKDI QYLK--DS-LAL-GK-SEDEALKNFKVKFNEALRESWKTKVNWMMHSLA----------- --------------------------------------------KDNRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >T_rubripes_ENSTRUP00000017655 ---------M-------------------------PPAMTDLLDIWATH-PLAGHDPD-- ------------------------------------------------------------ ---------------------------QITMDFLLPT-GI--------YIQCDVPRVATI KEIK-QLLWKEAHSFPMF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------SKL---GEMESHMFECVNQ---AAVHEELEDETRRLCDIRPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLKLVTRN-----CGRGE----RLLDSKIGVLIGK-------GLHELSAINDQEV KDFRSKMTR---ISEERMQTIE-R---MTCTEWLQASYSSQ--LDVPA-DTTTMDG--TD RP---ADLKII----------I-HFDQSLDSASLKMASTCTPRDLITQAVRKWLTTHGP- ---EE-------DALRGQYVLRVSHCLEFLCG-D-HPLIQ-YK--YI-RTC-MQAKE-PP HVTLVH--NNTI--KTM-----FE----RDIC---------------------------A IR----AALTPKSC--------------------------------------------SL PLPLPPK----------------------------------------------------- ------------------------------------------------------------ -----K----RAPTSPPQQVQTCVWDVSSP-FKIVLVNASKVN-------AEET-----A KVQVRAGLFHGTELLCK-PAVS----SESSGRS-----DH-AWKDTTLE-F-ELPVCDLP RMTRLCFAIYAVMD----KVKKQ--KSTKNTHINKYQTIRKA-G-----KVHYPIAWVNT MVFDYK-G----------------QLKTGDIILHCWSSFP--D-E--LEEMLNPIGTIQT NPYTEN---ATALH-----ISFPEYSS--HPIIFPLFDK--------ILEK--------- -----------------------------------------------AA-EIA-G----- -----ASDCASMGRG--GKKF----HIELKEIM----ERDALSQLCENEKDLIWTL-RYD CRENFPQSLPKL-LLSVKWSKHEDMA---QLQ---ALLQIW-----PRLCPRDALELLDF NYPDQYVREYAVNCL-RD-MSNDELSQYLLQLVQVLRYEPYYDCALTHFLLERAQS--SR KIGHFLFWHLRSEI-H------M-----------------------PAVSVQFSLILEAY CRGSI-PHIEVLKKQVEALNKLKAVNELIKLG--T---LKNAR-S-KTKEAMLTK----- EAMMTCLRQTG--FS----ETLSDLHSPLNPNILLSGI-N-VEKCRYMDSKMKPLWIVYN NKLLV-----GDML----GIIF--KNGD--DL-RQDMLTLQILRLMDRLWKEANLDLRIV PYGCLATGDRA---GLIEVVSSADTIANIQLTSSNMAAA-AAFNKDAL--LNWLKERN-S GD-------------------------ALERAIEEFTL-SCAGYCVATYVLGIGDRHSDN IMVRSNGQLFHIDFGHILGNFKSKFGIK--RERVPFILTHDFIHVIQQG--KT--G-QAE KFGSFR---------------QYCEKAYLILRKNGNFFITLFALMLTA-GLPELTSVKDI QYLK--DS-LAL-GK-SDDEALKQFRQKFDEALRESWTTKVNWMAHNVA----------- --------------------------------------------KDNRS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >C_familiaris_ENSCAFP00000029210 ---------M-------------------------PPGVDCPMEFWTKEEN------Q-- ------------------------------------------------------------ ---------------------------SVAVDFLLPT-GV--------YLNFPVSRNANL STIK-KVLWHRAQYEPLF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HML---SDPEAYVFTCVNQ---TAEQQELEDEQRRLCDIQPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLRLVARE-----GDRVK----KLVNSQISLLIGK-------GLHEFDSLRDPEV NDFRTKMRQ---FCEEAAARRQ-Q---LGWEAWLQYCFPLQ--LEPSA-RSWGPGT-LRV PS---RALLVN----------V-KFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQ- ---PL-------VEQPEDYTLQVNGKHEYLYG-S-YPLCQ-F------------------ ------------------------------------------------------------ ------QVQKPR----------------------------------------------TK PPPIPMK----------------------------------------------------- ------------------------------------------------------------ -----K----PSSLS--------LWSLEQP-FCVELIQGSKVN-------ADER-----M KLVVQAGLFHGNETLCK-TVSS----SEVSVCS-----EP-VW-KQRLE-F-DINVCDLP RMARLCFALYAVIE----KAKKA--RSTK----------KKS-K-----KADCPIAWANL MLFDYK-D----------------QLKTGECCLYMWPSVP--D-E--KGELLNPTGTVRS NPNTES---AAALV-----ICLPEVAP--YPVYYPTLDK--------V--SLLIAQALRN PNMLYM----RQPSPLRAAGPEARPGPGLGSPL-------RSGRLLQIL-ELG-R----- -----HGEHGRFS-----EEE----QLQLREIL----ERRGSGELYEHEKDLVWKM-RHE VQERFPEALARL-LLVTKWNKHEDVA---QML---YLLCSW-----PELPVLSALELLDF SFPDRHVGSFAIKSL-RK-LTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALA--NR KIGHFLFWHLRSEM-H------V-----------------------PSVALRFGLIMEAY CRGST-HHMKVLMKQGEALSKLKALNDFVKVS--S---QKTTK-P-Q------TK----- ELMHLCMRQEA--YL----EALSNLQSPLDPSTLLAEV-C-VEQCTFMDSKMKPLWVMYS NEEAG----SDGSV----GIIF--KNGD--DL-RQDMLTLQMIQLMDVLWKQEGLDLRMT PYGCLSTGDRT---GLIEVVLHSDTIANIQLNKSNMAAT-AAFNKDAL--LNWLKSKN-P GE-------------------------ALDRAIEEFTL-SCAGYCVATYVLGIGDRHSDN IMIRENGQLFHIDFGHFLGNFKTKFGIN--RERVPFILTYDFVHVIQQG--KT--N-NSE KFERFR---------------GYCERAYTILRRHGLLFLHLFALMRAA-GLPELSCSKDI QYLK--DS-LAL-GK-TEEEALKHFRVKFNEALRESWKTKVNWLAHNVS----------- --------------------------------------------KDNRQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >X_tropicalis_ENSXETP00000018101 ---STYPYRM-------------------------PPIM-DHMDIWTADTPLPP------ ------------------------------------------------------------ ---------------------------DICVDVLLPT-GI--------YVQMDVPRDASI SHIK-QLLWKHAQSYPLF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HLL---LEIDSYMFQCVNH---NAVHEELEDETQRLCDVRPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLKLVSRS-----CNPAE----K-LDSKIGVLIGK-------GLQEFDALKDNEV MEFRSKMRS---ISEAKIQSLL-G---LTWVEWLKRTFPPE--LEPSI-QDNIQG---KL YG---GNIVVA----------I-HFENCQDVFSFQVSPNMVPVKVNELAIRKRLTIHGR- ---EAE------EVDPEDFVLQVNGRLEFVFG-D-HPLIQ-FQ--YI-RNC-VMNKA-LP HLTLVE--CCNI--KKL-----FD----QEMS---------------------------E IE----HAVRRKSSMHP-----------------------------------------AL PMPLPPK----------------------------------------------------- ------------------------------------------------------------ -----K----RGASMKTLNMRDIVWNIVQP-YKIILSKGSRLN-------TEDS-----Y NVLVRAGLFHGTELLCK-PTMT----PEVQGKN-----DH-VW-NETLE-F-EINVCDLP RMARLCFAIYAVLD----KPRNK--------NKTKYQTIKKS-G-----KMHFPVAWVNT MVFDYK-G----------------QLRSGDHVLHCWSSFP--D-E--LEEMLNPMGTVRT NPYTEN---TTTLH-----IKFHDYSK--EPISYPPFDK--------ILEK--------- -----------------------------------------------AA-EIARN----- -----SDSLSTSGRG--GKKL----NIELKEIM----ERDPLCQLCENEKDLIWTL-RYD CRENFPGSLPKL-LLSVKWNKLEDVA---QLQ---ALLQIW-----SKLPPRDALELLDF NYPDQYVREYAVNCL-KP-MSDEELSQYLLQLVQVLKYEPFLDCALSRFLLQRALD--NR RIGQFLFWHLRSEV-H------N-----------------------PAVSVQFGLLLEAY CRGSV-AHMKVLSRQVEALNKLRTLNGLIKLN--A---VKLSK-V-K------NK----- DNMHTCLRENA--YK----EALMHIQSPLNPSITLSEL-V-VEKCKYMDSKMKPLWIVYN NRGFG-----SDSL----GIIF--KNGD--DL-RQDMLALQLLRLMDMLWKEAGLDLRIV PYGCLATGDRC---GFIEVVSAAETIADIQLDSSNLAAA-AAFNKDAL--LNWIKECH-S GD-------------------------DLERAIEEFTL-SCAGYCVATYVLGIGDRHNDN IMVRKTGQYFRMESATYDINFKSKFKIK--RERGPFILTYDFIHVIQQG--KP--G-NTE KFGRFR---------------QCCEDAYLILRRNGNLIITLFALMLTA-GLPELSSVKDI QYVK--DS-LAL-GK-KEEDALKQFRQKFDEALKESWTTKVNWMAHTMR----------- --------------------------------------------KDYKA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >O_anatinus_ENSOANP00000012983 ---------M-------------------------APGVDCPMELWSKEEN--------- ------------------------------------------------------------ ---------------------------QVLVDFLLPT-GV--------YLNFPVSRNANL SSIK-EILWRQAKREPLF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HML---SDPEAYVFTCINQ---TAEQQELEDEQRRLCDIQPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLRLVARE-----GDRAK----KLINSQISLLIGK-------GLHEFDSLRDPEV NDFRSKMRQ---FCEETAAQRQ-Q---LDWEAWMRYNFPLQ--LEPLA-MARTSGT--SF LS---KTILVV----------I-KFEGSEESFTLQVSLRDVPLALIAVALKKKATVFRP- ---PA-------LERPEEYTLQVNGKYEYLYG-N-YPLYQ-F------------------ ------------------------------------------------------------ ------QGPKLR----------------------------------------------PK PPPIPLK----------------------------------------------------- ------------------------------------------------------------ -----K----PASVA--------LWSLEQP-FWVELVQGSKVN-------ADER-----M KLVVQAGLFHGNEMLCK-MVSS----SEVNVCS-----EP-VW-KQRLE-F-DINVCDLP RMARLCFALYAVIE----KAKKA--RSTK----------KKS-K-----KADCPIAWANI MLFDYK-D----------------QLKSGECCLYMWSSVP--D-E--KGELLNPTGTVRS NPNTES---AAALV-----ICIPEVAP--HPVYYPALER--------VSGG--------D CEEVWVLAWSCDCPVERLFHFPVPEGSGLRQGLPLA---PESLFVLQIL-ELG-K----- -----NGEHARST-----EEE----QQQLKEIL----DRKLSGELYEHEKDLVWKM-RHE IQEQFPEALARL-LLVTKWNKHEDVA---QML---FLLRSW-----PELPVLSALELLDF SFPDRHVGSFAIKSL-RK-LTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALT--NR KIGHFLFWHLRSEM-H------V-----------------------PSVALRFGLIMEAY CRGSN-HHMKVLMKQGEALNKMKSLNDYVKVS--S---QKTPK-P-Q------AK----- ELMHTCMRQET--FL----EALSNLQSPLNPSTLLADV-C-VEQCTFMDSKMKPLWIVYS NG--G-----GDRE----PAAW--HHPF--NL-RQDMLTLQMIQLMDVLWKQEGLDLRMT PYGCLSTGDRT---GLIEVVLRSDTIANIQLNKSNMAAT-AAFNKDAL--LNWLKSKN-P GD-------------------------ALERAIEEFTL-SCAGYCVATYVLGIGDRHSDN IMIRETGQLFHIDFGHFLGNFKTKFGIN--RERVPFILTYDFVHVIQQG--RT--N-NSE KFERFR---------------GYCERAYTILRRHGLLFLHLFALMRAA-GLPELSCSKDI QYLK--DS-LAL-GK-TDDEALKHFRVKFNEALRESWKTKVNWLAHNVS----------- --------------------------------------------KDNRQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >G_aculeatus_ENSGACP00000007464 ---------M-------------------------PPAMTDLLDIWAAHSPLAGHVLD-- ------------------------------------------------------------ ---------------------------QVTVDFLLPT-GI--------YIQMDVPREATI QHIK-LLLWKQAQSFPLF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------PSL---GEMESHMFECVNQ---AAVHEELEDESRRLCDVRPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLRLVTRN-----CGRAE----RLLDSKIGVLIGK-------GLHELDAINDQEV KDFRSKMFR---LSEERMQKVQ-M---MTCTEWLQACFSPQ-------------EG-LND RP---ADLKVI----------I-HFDQSQDSASLKVASSCVPSELMEQALKKWLTTHGPE GGEEE-------EAWRGQYVLRVSHCLEFLCG-D-QPLIE-YK--YI-RSC-MQAKE-PP HLTLVH--ASNV--KVL-----FD----KEIS---------------------------A IG----AVVSRKSS--------------------------------------------NP PLPLPPK----------------------------------------------------- ------------------------------------------------------------ -----R----RAPT-------TCVWDVSQP-FKIVLVNGSKVN-------AEES-----A KVQVRAGLFHGTELLCK-PAVS----SESSGRS-----DH-TWNNSTLE-F-DLSVCDLP RMTRLCFAIYAVMD----KVKKQ--KSTKNLHTNKYQTIRKA-G-----KVHYPIAWVNT MVFDYK-G----------------QLKTGDIILHCWSSFP--V-Q--LREMLNPIGTIQT NPYTEN---ATALH-----IHFPEYMS--HSVVFPPFDK--------ILEK--------- -----------------------------------------------AA-ETV-K----- -----PNDL--MSRG--WKKF----NIELKEIM----ERDPLSQLCENEKDLIWTL-RHD CKDYFPQSLPKL-LLSVKWSKHEDMAQ--QLQ---ALLQVW-----PKLSPRDALELLDF NYPDQYVRKYAVGCL-RD-MSEEELSQYLLQLVQVLRYEPYYDCALTHFLLERAQG--NR KIGHFLFWHLRAEI-H------M-----------------------PAVLVQFALILEAY CRGSI--HIEILKKQVEALSKLKSVNELIKLG--T---IKNAR-S-KTKEAMLTK----- EAMMTCLRQSG--YS----ETLSDLHSPLNPNILLSGI-N-VEKCRYMDSKMKPLWIVYN NKLLG-----GDTL----GIIF--KNGD--DL-RQDMLTLQILRLMDLLWKEANLDLRIV PYGCLATGDRS---GLIEVVSSADTIANIQLTSSNVAAA-AAFNKDAL--LNWLKERN-S GD-------------------------ALERAIEEFTL-SCAGYCVATYVLGIGDRHSDN IMVRSTGQLFHIDFGHILGNFKSKFGIK--RERVPFILTHDFIHVIQEG--KT--G-YTE KFASFR---------------QYCEAAYLVLRKNGNLFITLFALMLTA-GLPELTSVKDI QYLK--DS-LAL-GK-TDEDALKQFRQKFDEALRESWTTKVNWMAHNVA----------- --------------------------------------------KDNRS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >H_sapiens_ENSP00000354410 ---------M-------------------------PPGVDCPMEFWTKEEN------Q-- ------------------------------------------------------------ ---------------------------SVVVDFLLPT-GV--------YLNFPVSRNANL STIK-QLLWHRAQYEPLF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HML---SGPEAYVFTCINQ---TAEQQELEDEQRRLCDVQPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLRLVARE-----GDRVK----KLINSQISLLIGK-------GLHEFDSLCDPEV NDFRAKMCQ---FCEEAAARRQ-Q---LGWEAWLQYSFPLQ--LEPSA-QTWGPGT-LRL PN---RALLVN----------V-KFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQ- ---PL-------VEQPEDYTLQVNGRHEYLYG-S-YPLCQ-F------------------ ------------------------------------------------------------ ------QVQKPR----------------------------------------------AK PPPIPAK----------------------------------------------------- ------------------------------------------------------------ -----K----PSSVS--------LWSLEQP-FRIELIQGSKVN-------ADER-----M KLVVQAGLFHGNEMLCK-TVSS----SEVSVCS-----EP-VW-KQRLE-F-DINICDLP RMARLCFALYAVIE----KAKKA--RSTK----------KKS-K-----KADCPIAWANL MLFDYK-D----------------QLKTGERCLYMWPSVP--D-E--KGELLNPTGTVRS NPNTDS---AAALL-----ICLPEVAP--HPVYYPALEK--------LPGGMLLASREWR PELLWMRLHAEDSAPSRMIG-VAMPGLGVLPGLVQAPGDAECSRLLQIL-ELG-R----- -----HSECVHVT-----EEE----QLQLREIL----ERRGSGELYEHEKDLVWKL-RHE VQEHFPEALARL-LLVTKWNKHEDVA---QML---YLLCSW-----PELPVLSALELLDF SFPDCHVGSFAIKSL-RK-LTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALA--NR KIGHFLFWHLRSEM-H------V-----------------------PSVALRFGLILEAY CRGST-HHMKVLMKQGEALSKLKALNDFVKLS--S---QKTPK-P-Q------TK----- ELMHLCMRQEA--YL----EALSHLQSPLDPSTLLAEV-C-VEQCTFMDSKMKPLWIMYS NEEAG----SGGSV----GIIF--KNGD--DL-RQDMLTLQMIQLMDVLWKQEGLDLRMT PYGCLPTGDRT---GLIEVVLRSDTIANIQLNKSNMAAT-AAFNKDAL--LNWLKSKN-P GE-------------------------ALDRAIEEFTL-SCAGYCVATYVLGIGDRHSDN IMIRESGQLFHIDFGHFLGNFKTKFGIN--RERVPFILTYDFVHVIQQG--KT--N-NSE KFERFR---------------GYCERAYTILRRHGLLFLHLFALMRAA-GLPELSCSKDI QYLK--DS-LAL-GK-TEEEALKHFRVKFNEALRESWKTKVNWLAHNVS----------- --------------------------------------------KDNRQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >R_norvegicus_ENSRNOP00000022718 ---------M-------------------------PPGVDCPMEFWTKEES------Q-- ------------------------------------------------------------ ---------------------------SVAVDFLLPT-GV--------YLNFPVSRNANL STIK-QVLWHRAQYEPFF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HML---SDPEAYVFTCVNQ---TAEQQELEDEQRRLCDIQPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLRLVARE-----GDRVK----KLINSQISLLIGK-------GLHEFDSLRDPEV NDFRTKMRQ---FCEEAAAHRQ-Q---LGWVEWLQYSFPLQ--LEPSA-R-WRAGL-LHV SN---RPLLVN----------V-K-DGSAESFTFQVSTKDMPLALMACALRKKATVFRQ- ---PL-------VERPEEYALQVNGRHEYLYG-S-YPLCH-FQ--YI-CSC-LHSGL-TP HLTMVH--SSSI--LAM-----RD----EQSN---------------------------P AP----QVQKPR----------------------------------------------VK PPPIPAK----------------------------------------------------- ------------------------------------------------------------ -----K----PSSVS--------LWSLEQP-FCIELIEGRKVN-------ADER-----M KLVVQAGLFHGNEMLCK-TVSS----SEVNVCS-----EP-VW-KQRLE-F-DISICDLP RMARLCFALYAVVE----KAKKA--RSTK----------KKS-K-----KADCPIAWANL MLFDYK-D----------------QLKTGERCLYMWPSVP--D-E--KGELMNPAGTVRG NPNTES---AAALV-----IYLPEVAP--HPVYFPALEK--------------------- -----------------------------------------------IL-ELG-R----- -----HGERGRIT-----EEE----QLQLREIL----ERRGSGELARGQTDSYRPP-PH- --------------LTTK------LS---QML---YLLCSW-----PELPVLSALELLDF SFPDCYVGSFAIKSL-RK-LTDDELFQYLLQLVQVLKYESYLDCELTKFLLGRALA--NR KIGHFLFWHLRSEM-H------V-----------------------PSVALRFGLIMEAY CRGST-HHMKVLMKQGEALSKLKALNDFVKAS--S---QKTTK-P-Q------TK----- EMMHMCMRQET--YM----EALSHLQSPLDPSTLLEEV-CSVEQCTFMDSKMKPLWIMYS SEKAG----GAGSV----GIIF--KNGD--DL-RQDMLTLQMIQLMDFLWKQEGLDLRMT PYGCLPTGDRT---GLIEVVLHSDTIANIQLNKSNMAAT-AAFNKDAL--LNWLKSKN-P GE-------------------------ALDRAIEEFTL-SCAGYCVATYVLGIGDRHSDN IMIRESGQLFHIDFGHFLGNFKTKFGIN--RERVPFILTYDFVHVIQQG--KT--N-NSE KFERFR---------------GYCERAYTILRRHGLLFLHLFALMRAA-GLPELSCSKDI QYLKASDS-LAL-GK-TEEEALKHFRVKFNEALRESWKTKVNWLAHNVS----------- --------------------------------------------KDNRQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >T_rubripes_ENSTRUP00000025672 ---------R-------------------------DSGVNGVIRQWKRRGR------G-- ------------------------------------------------------------ ---------------------------HIVMDFLLPT-GI--------FLKFPVSRNDTI RTIK-KMVWKNAQSEALY------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------AAL---GDPDSYVFTCINQ---TAEREELEEESRRISDVRPF --MC-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLRLVARV-----GDRVE----KLTNTQISQLTGK-------GLHEFEAQKNHEV DEFRAKMRT---FCEEKAQERQ-V---LPWLQWMECNFPCE--LEPCS-SPVECGG-VKS KN---TKIFIN----------V-KFEASDESFMLQQDPQDLPAALMRAALKKKATVFRS- ---V--------RQEPEDYTLQVNGRWEYIYG-R-HPLSQ-FK--YI-FSC-LRNSQ-NP HLTMVH--HSTI--RKY-----QE----EQGR---------------------------A CS----QAYKCHRP--------------------------------------------SR PPPLPLK----------------------------------------------------- ------------------------------------------------------------ -----K----QNTSS--------LWSINEP-FHIRLLHGSRVN-------AAEG-----M KLVVQAGLFHGSELLCK-MVTS----TEVAVCS-----EP-VW-DQKLE-F-DINFSDLP RMSRLCFALYAVIE----KNKKP--RGTK----------KKN-K-----KADCPIAWVNT MVFDYK-D----------------QLKTGEFLLSTWPSVP--D-D--KGDLLNPMGTVEK NPNVDS---AAGLL-----IQFPNVRP--HPLYYPPLEK--------------------- -----------------------------------------------IS-DLE-K----- -----NGFAVVAT-----KVE----HIKLKEIM----DNKNYTEIFEDEKELLWKL-RSV VCDHYPESLSKL-LLITKWNKREDVV---QMV---GLLRYW-----SDLPAIHALELLDY SFPDPAVRAFTIRCL-RK-LSDEELLQYLIQLVQVLKYESYLDCDLTTFLLERALS--NS RIGHFLFWHLKSEI-H------V-----------------------PSVSLRFSLILEAY CRGNI-WHIKLLIKQNEALLKMKTLSDIVKSG--S---QKMTV----------------- DDLKLCIKQES--YL----ETLSDLLSPLNPSVVLAEI-C-ADKCRFMDSKMKPLWLMYK SPWAQ-----GDMM----GIIF--KNGD--DL-RQDMLTLQMIRLMEILWKKEGLDLRMI PYGCLSTGNKM---GLIEVVKNSDTIANIQRNSSNSAAT-AAFNKDAL--LNWLKSKN-P EG-------------------------KLEKAIEEFTL-SCAGYCVATYVLGIGDRHNDN IMIRETGQLFHIDFGHFLGNFKRKLGIN--RERVPFILTYDFVHVIQQG--RT--N-NSE KFERFR---------------EYCERAYKILCRNGMLFVNLFAMMKAA-GLPELTSSKDI QYLK--DS-LAL-GK-SEEEALKNFKVKFNEALRESWKTKVNWMMHSLA----------- --------------------------------------------KDNR------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >O_anatinus_ENSOANP00000023160 ---KWLNSMM-------------------------PPAMADVLDIWAVDSQIAHD--G-- ------------------------------------------------------------ ---------------------------PITVDFLLPT-GV--------YVQLDVPREAPI SSIK-QMLWKQVHNYPLF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------SLL---TEIDSYMFACVNQ---TAVYEELEDETRRLCDVRPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLKLVTRN-----CDPGE----K-LDSKIGVLIGK-------GLHEFDALEDPEV NDFRSKMRQ---ISEAKIQSLV-G---LSWMDWLKHTYPPE--QEASI-LENIED---KL YG---GHLVVA----------V-HFENCQDVFSFQVSPNMNPLKLNELAIRKRLTIHGK- ---ED-------EVNPYDYVLQVSGKLEYVFG-D-DPLIQ-FQ--YI-RKC-VMNRT-LP QLTLVE--CCNI--KKM-----CE----QEMI---------------------------A IE----AAINRNSS--------------------------------------------NL PLPLPPK----------------------------------------------------- ------------------------------------------------------------ -----K----TRVVSS-------VWENSNP-FQIVLVKGSKLN-------TEET-----V KVHVRAGLFHGTELLCK-PVVS----SEIAGRN-----DH-VW-SETLE-F-DINICDLP RMARLCFAVYAVMD----KAKTK--KSTKAINPSKYQTIRKA-G-----KVHYPVAWVNT MVFDFK-G----------------QLKTGDIILHSWSSFP--D-E--LEEMLNPMGTVQT NPYTEN---ATALH-----IKFPENKR--QPYYYPPFDK--------IIEK--------- -----------------------------------------------AA-EIA-S----- -----SDSGNMASRG--GKKF----HVVLKEIM----ERDPLSQLCENEMDLIWTL-RQD CRENFPQSLPKL-LLSVKWNKLEDVA---QLQ---ALLQIW-----PKLPPREALELLDF NYPDQYVREYAVGCL-KQ-MSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALA--NR RIGQFLFWHLRSEV-H------I-----------------------PAISVQFGVILEAY CRGSV-GHMKVLSKQVEALNKLKTLNSLMKLN--A---VKLSR-A-K------GK----- EAMHSCLKQNA--YR----EALSDLQSPLNPCVILSEL-Y-IEKCKYMDSKMKPLWIVYN NKVFG-----GDPV----GIIF--KNGD--DL-RQDMLTLQMLRLMDLLWKEAGLDLRML PYGCLATGDRS---GLIEVVSTSETIADIQLNSSNVAAA-AAFNKDAL--LNWLKEYN-S GD-------------------------DLDRAIEEFTL-SCAGYCVASYVLGIGDRHSDN IMVRKTGQLFHIDFGHILGNFKSKFGIK--RERVPFILTYDFIHVIQQG--KT--G-NTE KFGRFR---------------QCCEDAYLILRRHGNLFITLFALMLTA-GLPELTSVKDI QYLK-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >P_troglodytes_ENSPTRP00000000229 ---------M-------------------------PPGVDCPMEFWTKEEN------Q-- ------------------------------------------------------------ ---------------------------SVVVDFLLPT-GV--------YLNFPVSRNANL STIK-QLLWHRAQYEPLF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HML---SGPEAYVFTCINQ---TAEQQELEDEQRRLCDVQPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLRLVARE-----GDRVK----KLINSQISLLIGK-------GLHEFDSLCDPEV NDFRAKMCQ---FCEEAAARRQ-Q---LGWEAWLQYSFPLQ--LEPSA-RTWGPGT-LRL PN---RALLVN----------V-KFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQ- ---PL-------VEQPEDYTLQVNGRHEYLYG-S-YPLCQ-F------------------ ------------------------------------------------------------ ------QVQKPR----------------------------------------------AK PPPIPAK----------------------------------------------------- ------------------------------------------------------------ -----K----PSSVS--------LWSLEQP-FRIELIQGSKVN-------ADER-----M KLVVQAGLFHGNEMLCK-TVSS----SEVSVCS-----EP-VW-KQRLE-F-DINICDLP RMARLCFALYAVIE----KAKKA--RSTK----------KKS-K-----KADCPIAWANL MLFDYK-D----------------QLKTGERCLYMWPSVP--D-E--KGELLNPTGTVRS NPNTDS---AAALL-----ICLPEVAP--HPVYYPALEK--------LPGGMLLASCEWR PELLWMRLHAEDSAPSRMIG-VAMPGLGVLPGLVQAPGDAECSCLLQIL-ELG-R----- -----HSECVHVT-----EEE----QLQLREIL----ERRGSGELYEHEKDLVWKL-RHE VQEHFPEALARL-LLVTK-NKHEDVA---QPD---ALPAVW-----PELPVLSALELLDF SFPDCHVGSFAIKSL-RK-LTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALA--NR KIGHFLFWHLRSEM-H------V-----------------------PSVALRFGLILEAY CRGST-HHMKVLMKQGEALSKLKALNDFVKLS--S---QKTPK-P-Q------TK----- ELMHLCMRQEA--YL----EALSHLQSPLDPSTLLAEV-C-VEQCTFMDSKMKPLWIMYS NEEAG----SGGSV----GIIF--KNGD--DL-RQDMLTLQMIQLMDVLWKQEGLDLRMT PYGCLPTGDRT---GLIEVVLRSDTIANIQLNKSNMAAT-AAFNKDAL--LNWLKSKN-P GE-------------------------ALDRAIEEFTL-SCAGYCVATYVLGIGDRHSDN IMIRESGQLFHIDFGHFLGNFKTKFGIN--RERVPFILTYDFVHVIQQG--KT--N-NSE KFERFR---------------GYCERAYTILRRHGLLFLHLFALMRAA-GLPELSCSKDI QYLK--DS-LAL-GK-TEEEALKHFRVKFNEALRESWKTKVNWLAHNVS----------- --------------------------------------------KDNRQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >G_aculeatus_ENSGACP00000009701 ---------M-------------------------PPGKYGMQEEWEKEWD------Q-- ------------------------------------------------------------ ---------------------------QIGMEFLLPT-GI--------YLKFPVSPNDTI KSIK-KMVWKNASSEALF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------SAL---GDPEAYVFTCINQ---TAEREELEEESRRIRDVRPF --MC-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLRLVARE-----GDRVE----KLTNTQISLLIGK-------GLHEFEAQKNHEV NEFRAKMRA---FCEETAQERQ-M---LPWQQWMEYSFPCE--LEPCC-SPCGFGR-VKS KNK--KKIFIN----------V-KFDACDESFMVQQDPQDLPVALMRSALKKKAAVFPT- ---L--------RQEPQDYTLQVNGRWEFIYG-K-HPMCQ-FK--YI-FSC-LRNGE-NP YLTMVH--HSAI--HKY-----QE----EQGR---------------------------M CS----QLYKSRSL--------------------------------------------SR PPPLPLK----------------------------------------------------- ------------------------------------------------------------ -----K----QNTSS--------LWSIREP-FYIHLLQGSRVN-------AGEG-----M KLVVQAGLFHGSELLCK-VMTT----SEVSVCS-----EP-LW-DQKLE-F-DINVADLP RMSRLCFALYAVIE----KAKKP--RGTK----------KKN-K-----KADCPIAWVNT MVFDYK-D----------------QLKTGEFLLSTWPSVP--A-D--KSDLLNPMGTVEK NPNVDS---AAGLL-----IRFPNIRP--HPLYYPPLDK--------------------- -----------------------------------------------LSGDME-K----- -----NGDATVAT-----KEE----YLKLKEIM----DNKNSTEFFEDEKELLWKL-RTE VRDRFHESLSKL-LLVTKWNRHEDVV---QMV---SLLRNW-----PDLPAIHALELLDY SFPDPAVRSFTIACL-RK-LSDDELLQYLIQLVQVLKYESYLDCDLTTFLLERALS--NW RIGHFLFWHLRSEI-H------V-----------------------ASVSLRFGLILEAY CRGNI-HHIRLLTKQNEALGKMKALSDFVKSG--S---QKMTA----------------- DDLKLCIRQES--YL----EALSDLLSPLNPSISLADI-C-ADKCRFMNSKMKPLWLMYN SG-AQ-----GDTV----GIIF--KNGDE-DL-RQDMLTLQMIQLMENLWKREGLDLRML PYGCLSTGNKM---GLIEVVKNSDTIANIQRNSSNSAAT-AAFNKDAL--LNWLKSKN-P ED-------------------------KLDPAIEEFTL-SCAGYCVATYVLGIGDRHNDN IMIRETGQLFHIDFGHILGNFKRKLGIN--RERVPFILTYDFVHVIQQG--RT--N-NSE KFERFR---------------EYCERAYKILCRNAMLFVNLFAMMKAA-GLPELTSFKDI QYLK--DS-LAL-GK-SEEEALKNFKVKFNEALRESWKTKVNWMMHSLA----------- --------------------------------------------KDNR------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >O_latipes_ENSORLP00000019450 -----VHFTM-------------------------PPAMTDLVDIWAAHSPLDGQAPV-- ------------------------------------------------------------ ---------------------------HVTMDFLLPT-GI--------YIQMEVPREATI QHIK-LLLWKQAKSFPLS------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------SFL---GEMESHMFECVNQ---AAVHEELEDETRRLCDVRPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VFRLVTRN-----CGRAE----RLLDSKIGVIIGK-------GLHELDGINDQEV KDFRSKMQR---LSEERMQRVQ-M---MSFTEWLQACFSPQ--LEPSA-GTAIADG-AND WP---ADLKVI----------I-HFDQSQDSTSLKVPSSCTPSVLIEIALKKWQTTHAP- ---EE-------ETNKDKHILRVSQCLDFLCG-D-HPLIQ-YK--YI-RSC-LQAKE-SP HLTLVH--INAV--KTI-----FD----KENA---------------------------A IG----AVVSRKSS--------------------------------------------NP PLPLPPK----------------------------------------------------- ------------------------------------------------------------ -----K----RAPT----QVQTCVWDVSRP-FKVVLVKGSTVN-------ADEN-----A KVQVRAGLFHGTELLCK-PAVS----SESSGRS-----NH-SLENNTLE-F-EISVCDLP RMTRLCFAIYAIME----KVKK---KSYKNPHINKYQTIRKA-G-----KVHYPIAWVNT MVFDYK-G----------------QLKTGDMILHCWSSFP--D-E--LEEMLNPIGTVRI NPYPEN---ATALH-----IHFPDYGP--HPIVFPPFDK--------ILEK--------- -----------------------------------------------AA-EIA-G----- -----SSDSTPIGRG--GKKF----HIELKEIM----ERDPLSQLCENEKDLIWTL-RLD CRENFPQSLPKL-LLSVKWSKHEDMA---QLQ---ALLQIW-----PKLSPRDALELLDF NYPDQYVREYAVSCL-RD-MSDEELLQYLLQLVQVLRYEPYYDCALTHFLLERAQK--NR KIGHFLFWHLRSEI-H------M-----------------------PAVSIQFALILEAY CRGSI-PHIEVLKKQVEALSKLKSVNELIKLG--T---IKNTR-S-KTKEAMLTK----- EAMITCLKQSG--YS----EALSDLHSPLNPNVLLSDI-N-VEKCRYMDSKMKPLWIVYN NKLMS-----SDTL----GIIF--KNGD--DL-RQDMLTLQILRLMDLLWKEANLDLRIV PYGCLATGDRA---GLIEVVSSADTIANIQLTSSNVAAA-AAFNKDAL--LNWLKERN-S GD-------------------------ALERAIEEFTL-SCAGYCVATYVLGIGDRHSDN IMVRSTGQLFHIDFGHILGNFKSKFGIK--RERVPFILTHDFIHVIQQG--KT--G-YTE KFGSFR---------------QYCEEAYLVLRKNGNLFITLFALMLTA-GLPELTSVKDI QYLK--DS-LAL-GK-SDEEALKQFRQKFDEALRESWTTKVNWMAHNVA----------- --------------------------------------------KDNRS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >T_nigroviridis_ENSTNIP00000018220 ---------M-------------------------PPGKYGMQEEWEKEGD------Q-- ------------------------------------------------------------ ---------------------------RIMMDFLLPT-GI--------FLKFPVSRNDTI KIIK-KMVWKNAQNEALY------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------AAL---GDPDAYVFTCINQ---TAEREELEEESRRISDVRPF --MC-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FLRLVARE-----GDRVE----KLTNTQISQLTGK-------GLHEFEAQKNHEV DEFRAKMRA---FCEEKAQERQ-M---LPWLEWMEYNFPCD--LEPCC-SPVDCGA-TKS KN---TKIFIN----------V-KFEACDESFMLQQDPQDLPVALMKAALKKKATVFRS- ---V--------RQEPEDYTLQVNGRWEFIYG-R-HPLSQ-FK--YI-FSC-LRNGQ-NP HLTMVH--HSTI--RKH-----QE----EQGH---------------------------M CS----QVYKGRSQ--------------------------------------------SR PPPLPLK----------------------------------------------------- ------------------------------------------------------------ -----K----QNTSS--------LWSINEP-FYIRLLHGSRVN-------AAEG-----M KLVVQAGLFHGSELLCK-VVTS----SEVAVCS-----EP-VW-DQRLE-F-DISVSDLP RMSRLCFALYAVIE----KNKKP--RGTK----------KKN-K-----KADCPIAWVNT MVFDYK-D----------------QLKTGEFLLSTWPSVPVTD-D--KGDLLNPMGTVEK NPNVDS---AAGLL-----IHFPNVRP--HPLYYPSPEK--------------------- -----------------------------------------------IS-DME-K----- -----NGFAVIAT-----KEE----HMKLKEIM----DNKNYTEIFEDEKELLWKL-RSV VRDHYPESLSKL-LLITKWNKREDVV---QMV---GLLRHW-----PDLPAIHALELLDY SFPDPSV-AFTVRCL-RK-LSDDELLQYLIQLVQVLKYESYLDCDLTTFLLERALS--NS RIGHFLFWHLNQKF-M------M-----------------------PSVSLRFSLMLEAY CRGNI-WHIKLLIKQNEALLKMKTLSDIVKTG--S---QKMTV----------------- DDLKLCIKQES--YV----ETLSDLLSPLNPSVFLAEI-C-ADKCRFMDSKMKPLWLMYK SPWAQ-----GDMM----GIIF--KNGDDLDL-RQDMLTLQMIRLMENLWKKEGLDLRMI PYGCLSTGDKM---GLIEVVKNSDTIANIQRNSSNSAAT-AAFNKDAL--LNWLKSKN-P EG-------------------------KLEKAIEEFTL-SCAGYCVATYVLGIGDRHNDN IMIRETGQLFHIDFGHFLGNFKRKLGIN--RERVPFILTYDFVHVIQQG--RT--N-NSE KFERFR---------------EYCERAYKILCRNGMLFVNLFAMMKAA-GLPELTSSKDI QYLK--DS-LAL-GK-SEEEALKNFKVKFNEALRESWKTKVNWMMHSLA----------- --------------------------------------------KDNRP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >P_pygmaeus_ENSPPYP00000015827 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MRK---FSEEKILSLV-G---LSWMDWLKQTYPPE--HEPSI-PENLED---KL YG---GKLIVA----------V-HFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGK- ---ED-------EVSPYDYVLQVSGRVEYVFG-D-HPLIQ-FQ--YI-RNC-VMNRT-LP HFILVE--CCKI--KKM-----YE----QEMI---------------------------A IE----AAINRNSS--------------------------------------------NL PLPLPPK----------------------------------------------------- ------------------------------------------------------------ -----K----TRIISH-------VWENNNP-FQIVLVKGNKLN-------TEET-----V KVHVRAGLFHGTELLCK-TIVS----SEVSGKN-----DH-IW-NEPLE-F-DINICDLP RMARLCFAVYAVLD----KVKTK--KSTKTINPSKYQTIRKA-G-----KVHYPVAWVNT MVFDFK-G----------------QLRTGDIILHSWSSFP--D-E--LEEMLNPMGTVQT NPYTEN---ATALH-----VKFPENKK--QPYYYPPFDK--------IIEK--------- -----------------------------------------------AA-EIA-S----- -----SDSANVSSRG--GKKF----LPVLKEIL----DRDPLSQLCENEMDLIWTL-RQD CREIFPQSLPKL-LLSIKWNKLEDVA---QLQ---ALLQIW-----PKLPPREALELLDF NYPDQYVREYAVGCL-QQ-MSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALG--NR RIGQFLFWHLRSEV-H------I-----------------------PAVSVQFGVILEAY CRGSV-GHMKVLSKQVEALNKLKTLNSLIKLN--A---VKLNR-A-K------GK----- EAMHTCLKQSA--YR----EALSDLQSPLNPCVILSEL-Y-VEKCKYMDSKMKPLWLVYN NKVFG-----EDSV----GVIF--KNGD--DL-RQDMLTLQMLRLMDLLWKEAGLDLRML PYGCLATGDRS---GLIEVVSTSETIADIQLNSSNVAAA-AAFNKDAL--LNWLKEYN-S GD-------------------------DLDRAIEEFTL-SCAGYCVASYVLGIGDRHSDN IMVKKTGQLFHIDFGHILGNFKSKFGIK--RERVPFILTYDFIHVIQQG--KT--G-NTE KFGRFR---------------QCCEDAYLILRRHGNLFITLFALMLTA-GLPELTSVKDI QYLK--DS-LAL-GK-SEEEALKQFKQKFDEALRESWTTKVNWMAHTVR----------- --------------------------------------------KDYRS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >M_mulatta_ENSMMUP00000008181 ---------M-------------------------PPGVDCPMEFWTKEEN------Q-- ------------------------------------------------------------ ---------------------------SVVVDFLLPT-GV--------YLNFPVSRNANL STIK-QLLWHRAQYEPLF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HML---SGPEAYVFTCINQ---TAEQQELEDEQRRLCDVQPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLRLVARE-----GDRVK----KLINSQISLLIGK-------GLHEFDSLCDPEV NDFRAKMCQ---FCEEAAARRQ-Q---LGWEAWLQYSFPLQ--LEPSA-RTWGPGT-LRL PN---RALLVN----------V-KFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQ- ---PL-------VEQPEDYTLQVNGRHEYLYG-S-YPLCQ-F------------------ ------------------------------------------------------------ ------QVQKPR----------------------------------------------AK PPPIPAK----------------------------------------------------- ------------------------------------------------------------ -----K----PFSVS--------LWSLEQP-FCIELIQGSKVN-------ADER-----M KVWVPLAGIEGDWIRGT-SRTS----GGKKSPS-----PP-TW-APR-----NLRSPGSP RMLEQG-GEWTCPE----KAKKA--RSTK----------KKS-K-----KADCPIAWANL MLFDYK-D----------------QLKTGERCLYMWPSVP--D-E--KGELLNPTGTVRS NPNTDS---AAALL-----ICLPEVAP--HPVYYPALEK--------LLGGMLLASRGWR PELLWICLHARDSAPSRMIG-VATPCLGILPGLVQALGDAECSCLLQIL-ELG-R----- -----HSECVHVT-----EEE----QLQLREIL----ERRGSGELYEHEKDLVWKL-RHE VQEHFPEALARL-LLVTKWNKHEDVA---QVD---ALPAVW-----PELPVLSALELLDF SFPDCHVGSFAIKSL-RK-LTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALA--NR KIGHFLFWHLRSEM-H------V-----------------------PSVALRFGLILEAY CRGST-HHMKVLMKQGEALSKLKALNDFVKLS--S---QKTPK-P-Q------TK----- ELMHLCMRQEA--YL----EALSHLQSPLDPSTLLAEV-C-VEQCTFMDSKMKPLWIMYS NEEAG----SGGSV----GIIF--KNGD--DL-RQDMLTLQMIQLMDILWKQEGLDLRMT PYGCLPTGDRT---GLIEVVLRSDTIANIQLNKSNMAAT-AAFNKDAL--LNWLKSKN-P GE-------------------------ALDRAIEEFTL-SCAGYCVATYVLGIGDRHSDN IMIRESGQLFHIDL-HFLGNFKTKFGI---RERVPFILTYDFVHVIQQG--KT--N-NSE KFERFR---------------GYCERAYTILRRHGLLFLHLFALMRAA-GLPELSCSKDI QYLK--DS-LAL-GK-TEEEALKHFRVKFNEALRESWKTKVNWLAHNVS----------- --------------------------------------------KDNRQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >D_melanogaster_FBpp0083348 ---------MNMMDNRALAYVAHQPKYETPPEEAEPPCMRFSVNLWKNEMLN-------- ------------------------------------------------------------ ---------------------------WVDLICLLPN-GF--------LLELRVNPANTI QVIK-VEMVNQAKQMPLG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------YVI---KEACEYQVYGIST----FNIEPYTDETKRLSEVQPY --FG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----ILSLGERT--DTTSFSSD----YELTKMVNGMIGT-------TFDHNRTHGSPEI DDFRLYMTQ---TCDNIELERS-A---YTWQQRLLYEHPLR--LANST-KMPELIR-ERH PT---RTFLIV----------V-KNENDQSTFTLSVNEQDTPFSLTESTLQKMNRSQMK- -----------MNDRTSDYILKVSGRDEYLLG-D-YPLIQ-FL--YI-QEM-LSDSA-VP NVVLQS--VYRL--ESY-----IN------------------------------------ ----------HHNEQAM-----------------------------------------VT KRPLPKKR---------------------------------------------------- ------------------------------------------------------------ -TVHLH----KSISS--------LWDMGNY-FQLTLHSISNVN-------FDKT---RAL KVGVHVCLYHGDKKLCA-QRST----DSPNGNF-----DTFLF-NDLVMDF-DIQMRNLP RMTRLCIVIFEVTK----MSRSK--KSSN----NKDIALKDVP------YNKNPLAWVNT TIFDHK-D----------------ILRTGRHTLYTWTYAD--DIQ--SVEVFHPLGTIEP NPRKEE---CALVD-----LTFLSSGT--GTVRYPSEEV--------VLQY--------- -----------------------------------------------AADREQ------- -----VNRLQRQLAG--PEKP----IKELKELMANYTGLDKIYEMVDQDRNAIWER-RND ILRELPEELSIL-LHCVYWKERDDVA---DMW---YLLKQW-----PLISIERSLELLDY AYPDPAVRRFAIRCL-HF-LKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALR--NQ RIGHYFFWHLRSEM-Q------T-----------------------PSMQTRFGLLLEVY LKGCK-HHVAPLRKQLHVLEKLKQGSLIAKKG--S---KEKVK----------------- TMLQDFLRDQR--NS----AVFQNIQNPLNPSFRCSGV-T-PDRCKVMDSKMRPLWVVFE NADVN-----ASDV----HIIF--KNGD--DL-RQDMLTLQMLRVMDQLWKRDGMDFRMN IYNCISMEKSL---GMIEVVRHAETIANIQKEKGMFSAT-SPFKKGSL--LSWLKEHNKP AD-------------------------KLNKAINEFTL-SCAGYCVATYVLGVADRHSDN IMVKRNGQLFHIDFGHILGHFKEKLGVR--RERVPFVLTHDFVYVINKG--FN--DRESK EFCHFQ---------------ELCERAFLVLRKHGCLILSLFSMMIST-GLPELSSEKDL DYLR--ET-LVL-DY-TEEKAREHFRAKFSEALANSWKTSLNWASHNFS----------- --------------------------------------------KNNKQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >T_guttata_ENSTGUP00000003815 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------GLHEFDSVQDPEV SDFRTKMCQ---FCEEKAAKRQ-Q---LSWAAWMEYNFPLQ--LEPVA-KGLGVGS-LQI PT---KNIFVN----------I-KFQSGGESFTFQISPWEFPITLMSYAIKKQATVFRH- ---ET-------VQKPEDYTLQVNGKCEYLYG-N-YPLYQ-FQ--HI-RSC-LQRGR-TP HLTMVH--SSAI--IAM-----RD----EQTN---------------------------G IT----SPPKAA----------------------------------------------PK PPPLPKK----------------------------------------------------- ------------------------------------------------------------ -----K----PNYGS--------LWSLEQP-FYIELVQGSKVN-------ADER-----M KLVVQAGLFHGTEMLCK-TVSS----SEVSVCS-----EP-VW-RQRLD-F-DISVCDLP RMARLCLALYAVVE----KAKKA--RSTK----------KKS-K-----KADCPIAWVNV MLFDYK-D----------------QLKTGECCLHMWSSFP--D-E--KGELLNPMGTVQC NPNTES---AAALV-----ICFP-VAA--HPVYYPSFAQ--------------------- -----------------------------------------------LL-ELG-R----- -----NGEQPRAAPE---DSE----ELQLREIL----ERRSHTELYEHEKDLVWKM-RYD IRDQYPQALAKL-LVITKWNKHEDVA---QMI---SLLQTW-----PELPVLNALELLDF SFPDRYVGSFAVNSL-KK-LTDDDVFQYLLQLVQVLKYESYLDCELTKFLLERALS--NR KIGHFLFWHLRSEM-H------V-----------------------PAVALRFGLILEAY CRGST-HHMKVLMKQGEALNKMKALNDFVKVS--S---QKATK-P-Q------TK----- EMMHMCMKQET--YR----EALSHLQNPLNPNIILAEV-C-VDQCTFMDSKMKPLWIVFN NEETG-----GGGV----GIIF--KNGD--DL-RQDMLTLQMIQLMDILWKQEGLDLRMT PYGCLSTGDKT---GLIEVILRSRTVSGCPVPLCRTSET-PGPGAQKS--LQVLHHEG-S RD-------------------------ALDQAIEEFTL-SCAGYCVATYVLGIGDRHSDN IMVRETGQLFHIDFGHFLGNFKTKFGIN--RERVPFILTYDFVHVIQQG--KT--N-NNE KFERFR---------------GYCERAYMILRRHGLLFLHLFALMKAA-GLPELSCSKDI QYLK--DS-LAL-GK-TDEEALKHFRVKFNEALRESWKTKVNWLAHNVS----------- --------------------------------------------KDNRQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >G_gorilla_ENSGGOP00000012094 ---------M-------------------------PPGVDCPMEFWTKEEN------Q-- ------------------------------------------------------------ ---------------------------SVVVDFLLPT-GV--------YLNFPVSRNANL STIK-QLLWHRAQYEPLF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HML---SGPEAYVFTCINQ---TAEQQELEDEQRRLCDVQPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLRLVARE-----GDRVK----KLINSQISLLIGK-------GLHEFDSLCDPEV NDFRAKMCQ---FCEEAAARRQ-Q---LGWEAWLQYSFPLQ--LEPSA-RTWGPGT-LRL PN---RALLVN----------V-KFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQ- ---PL-------VEQPEDYTLQVNGRHEYLYG-S-YPLCQ-F------------------ ------------------------------------------------------------ ------QVQKPR----------------------------------------------AK PPPIPAK----------------------------------------------------- ------------------------------------------------------------ -----K----PSSVS--------LWSLEQP-FRIELIQGSKVN-------ADER-----M KLVVQAGLFHGNEMLCK-TVSS----SEVSVCS-----EP-VW-KQRLE-F-DINICDLP RMARLCFALYAVIE----KAKKA--RSTK----------KKS-K-----KADCPIAWANL MLFDYK-D----------------QLKTGERCLYMWPSVP--D-E--KGELLNPTGTVRS NPNTDS---AAALL-----ICLPEVAP--HPVYYPALEK--------LPGGMLLASREWR PELLWMRLHAEDSTPSRMIG-VAMPGLGVLPGLVQAPGXAECSCLLQIL-ELG-R----- -----HSECVHVT-----EEE----QLQLREIL----ERXXXGELYEHEKDLVWKL-RHE VQEHFPEALARL-LLVTKWNKHEDVA---QML---YLLCSW-----PELPVLSALELLDF SFPDCHVGSFAIKSL-RK-LTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XX XXXXXXXXXXXSEM-H------V-----------------------PSVALRFGLILEAY CRGST-HHMKVLMKQGEALSKLKALNDFVKLS--S---QKTPK-P-Q------TK----- ELMHLCMRQEA--YL----EALSHLQSPLDPSTLLAEV-C-VEQCTFMDSKMKPLWIMYS NEEAG----SGSSV----GIIF--KNGD--DL-RQDMLTLQMIQLMDVLWKQEGLDLRMT PYGCLPTGDRT---GLIEVVLRSDTIANIQLNKSNMAAT-AAFNKDAL--LNWLKSKN-P GE-------------------------ALDRAIEEFTL-SCAGYCVATYVLGIGDRHSDN IMIRESGQLFHIDFGHFLGNFKTKFGIN--RERVPFILTYDFVHVIQQG--KT--N-NSE KFERFR---------------GYCERAYTILRRHGLLFLHLFALMRAA-GLPELSCSKDI QYLK--DS-LAL-GK-TEEEALKHFRVKFNEALRESWKTKVNWLAHNVS----------- --------------------------------------------KDNRQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >A_aegypti_AAEL002903-PA ------------------------------------MVMMFNYDYWANPEE--------- ------------------------------------------------------------ ---------------------------HADITFFLPN-GV--------LIILNYSIYTTL QDLK-ADVWEEAERYPLY------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------CHL---GDKSMYFFSTISS--ANNNSYELNDESKRLIDIQPV --FN-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MFRFVEKQ------VSVN----NKLINNITNLLGK-------TLSE-KTLKNPEV NDFRTKMSY---LCEDIANKRA-N---MNRMQRIAYQYPPK--LVSCE-HIPEVVK-KRM ING--GDFCVV-------------ARCSDIAVTVKIPCKATPNEVIKRILDKKQILANT- -----------RNENSSEFILKVCGREEYLFG-D-HPIIN-FQ--YV-QDS-LSREE-TP TFVPKL--LRNVDIFED------------------------------------------N IYEIPEDITQRTNSTGS-----------------------------------------RQ PAHTLRK----------------------------------------------------- ------------------------------------------------------------ ----------VKYVP--------SWDTEGT-FMCMVKEINALN-------CDSN---RNV EVGITLGLFHGGKSLCK-PMKT----ELVALNG----GRA-VW-NETIV-F-DIDVKNVP RMARLCLVIYELVR----TAKGS-----------GVRARRTKD------GFMNPIAWVNT MLYDYK-S----------------QLKSGPVTLYTWTYAE--DLQ--SEDVLHPLGTVEP NPRRDE---CSSII-----LSFHSYYNEHKIVVYPSEEQ--------LLDH--------- -----------------------------------------------ASKMRKI------ -----NRHLNRD-----SAEE----VRPIKEILLPYMHNDKLNDMHEQDRNAIWAK-RRE CMTLEPDGLPCL-LYCVEWNDRNEVA---EIV---SLLQEW-----PILPVERALELLDY AYADQYVRRYAVKCL-RT-IQDDELLLYLLQLVQAMKHESYIYSDLVDFLLQRSLN--NQ HIGHFFFWHLRSEI-L------V-----------------------PSVQVRFSLILEAY LKGSQ-EHISILLKQMQCLRKLQHGSELVKKG--N---KEKGK----------------- SLLMDYLQDKP--VG----DALSDVISPLNPSFRCKTV-R-KEKCKVMDSKMRPLWIVYQ NSDSN-----GDDI----NMIF--KNGD--DL-RQDMLTLQMLRIMDRIWKSHGYDFRMN PYSCISTDRRL---GIIEVVLNAETIANIQKERGMFSAT-SPFKKGSL--LTWLKEHNTT EE-------------------------MLAKAIQEFTL-SCAGYCVATYVLGVGDRHSDN IMVKKTGQLFHIDFGHILGHFKEKFGFR--RERVPFVLTHDFVYVINNG--RT--DREAK EFRQFQ---------------HLCEEAFLILRKHGCLILSLFAMMIST-GLPELSSEKDL NYLR--ET-LVL-DL-PEEDARTHFKSKFSEALANSWKTSLNWASHNFS----------- --------------------------------------------KNNKQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >O_cuniculus_ENSOCUP00000009513 ---------M-------------------------PPGVDCPMEFWTKEEN------Q-- ------------------------------------------------------------ ---------------------------NVAVDFLLPT-GI--------YLNFPVSRNANL STIK-QVLWHRAQYEPLF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HML---SDPEAYVFTCVSQ---TAEPQELEDEQRRLCDVQPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLRLVARE-----GDRVK----KLINSQISLLIGK-------GLHEFDSLRDPEV NDFRTKMRQ---FCEEAAVRRQ-Q---LGWEAWLQYSFPLQ--LEPSA-RSWGAGA-LHA PN---RALLVN----------V-KFEGSEESFTFQVSTKDMPLALMACALRKKATVFRQ- ---PL-------AEQPEDYTLQVNGRHEYLYG-S-YALCQ-F------------------ ------------------------------------------------------------ ------QVQKPR----------------------------------------------TK PPPVPM------------------------------------------------------ ------------------------------------------------------------ -----K----XXXXX--------XXXXXXX-XXXXXXXXXXXX-------XXXX-----X XXXXXXXXXXXXXXXXX-XXXX----XXXXXXX-----XX-XX-XXXXX-X-XXXXXXXX XXXXXXXXXXXXXX----XXXXX--XXXX----------XXX-X-----XXDCPIAWANL MLFDYK-D----------------QLKTGERCLYMWPSVP--D-E--KGELLNPTGTVRG NPNTES---AAALV-----ICLPEVAP--HPVYYPPLEK--------L-GEVLLAPWGWR LAVL-MCPGARGSPHQRAVG-MQMPT-GALPGLVQA--GPESSHSLQIL-ELG-R----- -----HGERAPTS-----EEE----QLQLREIL----ERRGSGELYEHEKDLVWKM-RHE VQERFPEALARL-LLVTKWNKHEDVA---QML---HLLCSW-----PELPVLSALELLDF SFPDCHVGSFAIKSL-RK-LTDEELFQYLLQLVQVLKYESYLDCELTKFLLGRALA--NR KIGHFLFWHLRSEM-H------V-----------------------PSVALRFGLIMEAY CRGST-HHMKVLMKQGEALSKLKALNDFVKVS--S---QKTTK-P-Q------TK----- ELMHLCMRQEA--YL----EALSHLQSPLDPSTLLAEV-C-VEQCIFMDSKMKLLWIVYS NEEAG----SEGSV----GIIF--KNGD--DL-RQDMLTLQMIQLMDVLWXXXXXXXXMT PYGCLPTGDRT---GLIEVVLHSDTIANIQLNKSNMAAT-AAFNKDAL--LNWLKSKN-P GE-------------------------ALDRAIEEFTL-SCAGYCVATYVLGIGDRHSDN IMIRESGQLFHVDFGHFLGNFKTKFGIN--RERVPFILTYDFVHVIQQG--KT--N-NSE KFERFR---------------GYCERAYTILRRHGLLFLHLFALMRAA-GLPELSCPKDI QYLK--DS-LAL-GK-TEEEALKHFRVKFNEALRESWKTKVNWLAHNVS----------- --------------------------------------------KDNRQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >A_gambiae_AGAP000018-PA ------------------------------------------YGFWKNPDE--------- ------------------------------------------------------------ ---------------------------STELIFLMPN-GV--------MITMYIPIHITL DELK-SDVWEEAERYPLY------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------CHL---GDKNKYCFGTLAAGRTNSNTTYENEAETRLMDVQPT --LG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----ILRFVEKS-----NVSEN----TKLMENISSLLDS-------KLPV-KTLVNPEV NDFRAKMSM---LSEDIGSRRA-V---MTRMERIAYQYPAK--LVSGA-HVPEPIS-RRL TN---GDFCVV-------------AISTDMQLTVKVPCRATPDEVLKRILKKQNPSKAR- -----------NENSSTEYILKVCGREEYIYG-A-HPMIS-FQ--YV-QDC-LSRDE-TP TFVPRL--VRTVEVFKN------------------------------------------D IYDAREDFTQWSAS--------------------------------------------AK PSS--------------------------------------------------------- ------------------------------------------------------------ ----------VKYIT--------SWEIDAK-LQCTVHEIRGLN-------VESD-----K ELGVQLGLFHGGKSLCK-TERT----RTVTVNS----GAA-TW-NETIL-F-DINVSNVP RMARLCLVVYENMR----TAKGT-----------GIRTRRTKD------GLINPIAWVNT MVYDYK-N----------------QLKVDSVTLYTWDYAE--DAQ--SEDILHPLGTVEP NPNRDN--MVVSVL-----LSFGTYGPEGRIIVYPGEEE--------LLSH--------- -----------------------------------------------AAKMSHR------ -----NEHLNRE-----SAED----TRSIRAIMSAYMYNDRLNDIHEQDRNAIWAK-RRE CMKQMPQGLPCL-LYCVEWNNRDEVS---EIV---SLLQEW-----PKLLVERALELLDY AYADKYVRRYAVDCL-RT-IEDDELLLYLLQLVQALKHESYLNCDLVYFLLQRALH--NQ HIGHYLFWHLRSEI-S------V-----------------------PSVQVRFGLILEAY LLGSP-EHVAVLLKQMQCLRYLQTCSDNVKKG--S---KEKGR----------------- TLLIEQLAKEG--------HVTSDLISPLNPSYRCKAV-R-TDRCKVMDSKMRPLWIVYE NSDAN-----GDDI----HMIF--KNGD--DL-RQDMLTLQMLRIMDRIWKSHGYDFRMN PYSCISTDHKL---GLIEVVLNAETIANIQKERGMFSAT-SPFKKGSL--LAWLREHNGT ED-------------------------LLAKAIQEFTL-SCAGYCVATYVLGVADRHSDN IMVKKTGQLFHIDFGHILGHFKEKFGFR--RERVPFVLTHDFVYVINNG--RT--DREAQ EFCRFQ---------------TLCEEAFLILRQHGCLILSLFSMMIST-GLPELSSEKDL NYLR--ET-LVL-DK-TEEEARTHFKLKFSEALANSWKTSLNWASHNFS----------- --------------------------------------------KNNRQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >C_intestinalis_ENSCINP00000010700 ---------------------------------------------WGYHNS------M-- ------------------------------------------------------------ ---------------------------YVSVDFFLPT-GI--------YIPIDIPRNSTI KEVK-NLLWQEAIHHPLF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------SKL---LNPESYTFTYITS---FGLPEEIVDESRHLSEFDIF HELP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLKLVQSR-----GNIAE----KRVIQEINHLTCI-------K-NETELNVDSES RSFRKDMRE---LAAQACKDRD-T---LHWKSLLQRHFPPT--IIPYL-NES-----THY LK---DFGLIQ----------L-TSENSETVYTIKINPSWSTEHLTEVALQTWVSKTKA- ---RLP------STNKDDYVLKGNGK-EFIVG-N-HPIYI-FV--LT-QT---------- ------------------------------------------------------------ ----------------------------------------------------------NF APPVPEK----------------------------------------------------- ------------------------------------------------------------ -----H----RAVWS--------LWQLDVM-FKLRIIRAGNVN-------AGQE---RDK KLVVHVGLYHGTETLCP-TTYTKEPVKEMAAGN-----EY-QW-DEECF-F-DINAVNLP RNAMLCLAICSSKRNVGGKSKRK--ESTQ----------KNT-Q-----HSASPIAWANM MVFDFK-R----------------YLKAGLVCMFKYTYQLNHDNL--DSNNLSPRGGVML NPDVEQ---AAFIE-----IMMPEYQA---TIMYPSLPE--------VRSKECLTQRFLK WGKFRIFRGATKYLANTSLLNYAISIHIQRTPFNIKI----------QT-QVL-E----- -----EAARQAVVRA--SKSH----MTQLDEVV----RKDRFDDLFDDDKSLLWRL-RID CREKYPEALSKV-LASAKWNSYKSVA---MVQ---AMLNSW-----TPLSPERAMELLDC QFADEHVRDFAVKCL-EN-LRDDELQQYLMQLVQVVKFDSYLNSSLVRFILRRAWS--NR KIGHFLFWHLKAEI-S------N-----------------------TLLNLRFALIMEAY LYGNL-PHVKTLYKQQEALNKMRTLNERVKGSEFS---QKDIK-V-R------AR----- QALKDTANQDS--FK----EALTSVECPLEPNLDLEEL-L-VEKCKVMNSKMRPLWLVFK NKQVQ-----DGSM----SVIY--KNGD--DL-RQDMLTLQTISIMDMLWKAEGLDLRMI PYGCLATGKGT---GMIEVVTHSNTIANIQ--KTRGGKM-SAFRHQTL--IEWLEQNNST PS-------------------------EFEQAIENFTY-SCAGYCVATFVLGVGDRHSDN IMVTEKGQLFHIDFGHILGNFKTKFGIK--RERVPFVLAHDFVHVINKG--KT--N-NKA DFDQFR---------------KLCDNAFCILRKKGYLIITLFALMLHS-GLPEMTSLDHL EYLR--ET-LAL-HL-TEQKALQQFRSKFNKALTDAWATSVNWFFHNVA----------- --------------------------------------------RDNT------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >H_sapiens_ENSP00000352121 -------------------MELENYKQPVVLREDNCRRRRRMKPRSA---AASLSSME-- ------------------------------------------------------------ ---------------------------LIPIEFVLPT-SQRKC-KSPETALLHVAGHGNV EQMK-AQVWLRALETSVA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------ADFYHRLGPHHFLLLYQKK----GQWYEIYDKYQVVQTLDCL RYWK--ATHRSPG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QIHLVQRH----PPSEES----QAFQRQLTALIGY-------DVTDVSNVHDDEL EFTRRGLVT---PRMAEVASRD----------PKLYAMHPW--VTSKP--LPEYLW-KKI AN---NCIFIV-------------IHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSL- MDIPE-------SQSEQDFVLRVCGRDEYLVG-E-TPIKN-FQ--WV-RHC-LKNGE-EI HVVLDT--PPDP--ALD-----EVRK--EEWP---------------------------L VD----DCTGVTGYHEQ-----------------------------------------LT IHG--KDH---------------------------------------------------- ------------------------------------------------------------ ----ES----VFTVS--------LWDCDRK-FRVKIRGIDIPV-------LPRN---TDL TVFVEANIQHGQQVLCQ-R-RT----SPKPFTE-----EV-LW-NVWLE-F-SIKIKDLP KGALLNLQIYCGKA-PALSSKAS---------AESP--SSES-K-----GKVQLLYYVNL LLIDHR-F----------------LLRRGEYVLHMWQISGKGE-D--QGSFNADKLTSAT NPDKEN---SMSIS-----ILLDNYCH---PIALPKHQP--------TPD---------- ------------------------------------------------------------ -----PEGDRVRAEM--PNQL----RKQLEAII----ATDPLNPLTAEDKELLWHF-RYE SL-KHPKAYPKL-FSSVKWGQQEIVA---KTY---QLLARREVWDQSALDVGLTMQLLDC NFSDENVRAIAVQKL-ES-LEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLR--NK RIGHFLFWFLRSEIAQ------S-----------------------RHYQQRFAVILEAY LRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSL--S---AEKYDVS--------SQVI--- SQLKQKLENLQ--NS----QLPESFRVPYDPGLKAGAL-A-IEKCKVMASKKKPLWLEFK CADPTAL--SNETI----GIIF--KHGD--DL-RQDMLILQILRIMESIWETESLDLCLL PYGCISTGDKI---GMIEIVKDATTIAKIQ--QSTVGNT-GAFKDEVL--NHWLKEKSPT EE-------------------------KFQAAVERFVY-SCAGYCVATFVLGIGDRHNDN IMITETGNLFHIDFGHILGNYKSFLGIN--KERVPFVLTPDFLFVMGTS--GK--K-TSP HFQKFQ---------------DICVKAYLALRHHTNLLIILFSMMLMT-GMPQLTSKEDI EYIR--DA-LTV-GK-NEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQG------ --------------------------------------------EKHSA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >P_troglodytes_ENSPTRP00000044953 -------------------MELENYKQPVVLREDNCRRRRRMKPRSA---AASLSSME-- ------------------------------------------------------------ ---------------------------LIPIEFVLPT-SQRKC-KSPETALLHVAGHGNV EQMK-AQVWLRALETSVA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------ADFYHRLGPDHFLLLYQKK----GQWYEIYDKYQVVQTLDCL RYWK--ATHRSPG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QIHLVQRH----PPSEES----QAFQRQLTALIGY-------DVTDVSNVHDDEL EFTRRGLVT---PRMAEVASRD----------PKLYAMHPW--VTSKP--LPEYLW-KKI AN---NCIFIV-------------IHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSL- MDIPE-------SQSEQDFVLRVCGRDEYLVG-E-TPIKN-FQ--WV-RHC-LKNGE-EI HVVLDT--PPDP--ALD-----EVRK--EEWP---------------------------L VD----DCTGVTGYHEQ-----------------------------------------LT IHG--KDH---------------------------------------------------- ------------------------------------------------------------ ----ES----VFTVS--------LWDCDRK-FRVKIRGIDIPV-------LPRN---TDL TVFVEANIQHGQQVLCQ-R-RT----SPKPFTE-----EV-LW-NVWLE-F-SIKIKDLP KGALLNLQIYCGKA-PALSSKAS---------AESP--SSES-K-----GKVQLLYYVNL LLIDHR-F----------------LLRRGEYVLHMWQISGKGE-D--QGSFNADKLTSAT NPDKEN---SMSIS-----ILLDNYCH---PIALPKHQP--------TPD---------- ------------------------------------------------------------ -----PEGDRVRAEM--PNQL----RKQLEAII----ATDPLNPLTAEDKELLWHF-RYE SL-KHPKAYPKL-FSSVKWGQQEIVA---KTY---KLLARREVWDQSALDVGLTMQLLDC NFSDENVRAIAVQKL-ES-LEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLR--NK RIGHFLFWFLRSEIAQ------S-----------------------RHYQQRFAVILEAY LRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSL--S---AEKYDVS--------SQVI--- SQLKQKLENLQ--NS----QLPESFRVPYDPGLKAGAL-A-IEKCKVMASKKKPLWLEFK CADPTAL--SNETI----GIIF--KHGD--DL-RQDMLILQILRIMESIWETESLDLCLL PYGCISTGDKI---GMIEIVKDATTIAKIQ--QSTVGNT-GAFKDEVL--NHWLKEKSPT EE-------------------------KFQAAVERFVY-SCAGYCVATFVLGIGDRHNDN IMITETGNLFHIDFGHILGNYKSFLGIN--KERVPFVLTPDFLFVMGTS--GK--K-TSP HFQKFQ---------------DICVKAYLALRHHTNLLIILFSMMLMT-GMPQLTSKEDI EYIR--DA-LTV-GK-NEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQG------ --------------------------------------------EKHSA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >E_caballus_ENSECAP00000017454 -------------------MELENYEQPVVLREDNRRRRRRMKPRSA---AASLSSME-- ------------------------------------------------------------ ---------------------------LIPIEFVLPT-SQRNS-KTPETALLHVA-HGNV EQMK-AQVWLRALETSGA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------ADFYHRLGPDHFLLLYQKK----GQWYEIYDKYQVVQTLDCL RYWK--VLHRSPG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QIHVVQRH----APSEDT----VAFQQQLTALIGY-------DVTDVSNVHDDEL EFTRRRLVT---PRMAEVAGRD----------PKLYAMHPW--VTSKP--LPEYLL-KKI TN---NCIFIV-------------IHRSTTSQTIKVSADDTPGTILQSFFTKMAKKKSL- MDIPE-------SQNEQDFVLRVCGRDEYLVG-E-TPIKN-FQ--WV-RQC-LKNGE-EI HLVLDT--PPDP--ALD-----QVRK--EEWP---------------------------L VD----DCTGVTGYHEQ-----------------------------------------LT IHG--KDH---------------------------------------------------- ------------------------------------------------------------ ----ES----VFTVS--------LWDCDRK-FRVKVRGIDIPV-------LPRN---ADL TVFVEANIQHGQQVLCQ-R-RT----SPKPFTE-----EV-LW-NVWLE-F-SIKIKDLP KGALLNLQIYCGKA-PALSGKAS---------ADTP--SSES-K-----GKVQLLYYVNL LLIDHR-F----------------LLRHGEYVLHMWQLSGKGE-D--QGSFNADKLTSAT NPDKEN---SMSIS-----ILLDNYCH---PIALPKHRP--------TPD---------- ------------------------------------------------------------ -----PEGDRVRAEM--PNQL----RKQLEAII----ATDPLNPLTAEDKELLWHF-RYE SL-KHPKAYPKL-FSSVKWGQQEIVA---KTY---QLLAKREVWDQSALDVGLTMQLLDC SFPDENVRAIAVQKL-ES-LEDDDVLHYLLQLVQAVKFEPYHDSALVRFLLKRGLR--NK RIGHFLFWFLRSEIAQ------S-----------------------RHYQQRFAVILEAY LRGCGMAMLHDFTQQVQVIEVLQKVTIDIKSL--S---AEKYDVS--------SQVI--- SQLKQKLENLQ--NL----NLPQSFRVPYDPGLKAGAL-V-IEKCKVMASKKKPLWLEFK RADPTAL--SNETI----GIIF--KHGD--DL-RQDMLILQILRIMESIWETESLDLCLL PYGCISTGDKI---GMIEIVKDATTIAKIQ--QSTVGNT-GAFKDEVL--SHWLKERCPL EE-------------------------KFQAAVERFVY-SCAGYCVATFVLGIGDRHNDN IMITETGNLFHIDFGHILGNYKSFLGIN--KERVPFVLTPDFLFVMGTS--GK--K-TSL HFQKFQ---------------DVCVKAYLALRHHTNLLIILFSMMLMT-GMPQLTSKEDI EYIR--DA-LTV-GK-NEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQG------ --------------------------------------------EKHSA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >M_mulatta_ENSMMUP00000014942 -------------------MELENYEQPVVLREDNCRRRRRMKPRSA---AASLSSME-- ------------------------------------------------------------ ---------------------------LIPIEFVLPT-SQRKC-KSPETALLHVAGHGNV EQMK-AQVWLRALETSMA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------SDFYHRLGPDHFLLLYQKK----GQWYEIYDKYQVVQTLDCL RYWK--ATHRSPG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QIHLVQRR----PPSEES----QAFQRQLTALIGY-------DVTDVSNVHDDEL EFTRRGLVT---PRMAEVASRD----------PRLYAMHPW--VTSKP--LPEYLW-KKI AN---NCIFIV-------------IHRSTTSQTIKVSPDDTPGTILQSFFTKMAKKKSL- MDIPE-------SQSEQDFVLRVCGRDEYLVG-E-TPIKN-FQ--WV-RHC-LKNGE-EI HLVLDT--PPDP--ALD-----EVRK--EEWP---------------------------L VD----DCTGVTGYHEQ-----------------------------------------LT IHG--KDH---------------------------------------------------- ------------------------------------------------------------ ----ES----VFTVS--------LWDCDRK-FRVKIRGIDIPV-------LPRN---TDL TVFVEANIQHGQQVLCQ-R-RT----SPKPFTE-----EV-LW-NVWLE-F-SIKIKDLP KGALLNLQIYCGKA-PAVSSKAS---------AESP--SSES-K-----GKVQLLYYVNL LLIDHR-F----------------LLRRGEYVLHMWQISGKGE-D--QGSFSADKLTSAT NPDKEN---SMSIS-----ILLDNYCH---PIALPKHQP--------TPD---------- ------------------------------------------------------------ -----PEGDRVRAEM--PNQL----RKQLEAII----ATDPLNPLTAEDKELLWHF-RYE SL-KHPKAYPKL-FSSVKWGQQEIVA---KTY---QLLARREVWDQSALDVGLTMQLLDC NFSDENVRAIAVQKL-ES-LEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLR--NK RIGHFLFWFLRSEIAQ------S-----------------------RHYQQRFAVILEAY LRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSL--S---AEKYDVS--------SQVI--- SQLKQKLENLQ--NS----QLPKSFRVPYDPGLKAGAL-A-IEKCKVMASKKKPLWLEFK CADPTAL--SNETI----GIIF--KHGD--DL-RQDMLILQILRIMESIWETESLDLCLL PYGCISTGDKI---GMIEIVKDATTIAKIQ--QSTVGNT-GAFKDEVL--NHWLKEKSPT EE-------------------------KFQAAVERFVY-SCAGYCVATFVLGIGDRHNDN IMITETGNLFHIDFGHILGNYKSFLGIN--KERVPFVLTPDFLFVMGTS--GK--K-TSL HFQKFQ---------------DTCVKAYLALRHHTNLLIILFSMMLMT-GMPQLTSKEDI EYIR--DA-LTV-GK-NEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQG------ --------------------------------------------EKHSA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >P_pygmaeus_ENSPPYP00000020059 -------------------MELENYKQPVVLREDNCRRRRRMKPRSA---AASLSSME-- ------------------------------------------------------------ ---------------------------LIPIEFVLPT-SQRKC-KSPETALLHVAGHGNV EQMK-AQVWLRALETSVA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------ADFYHRLGPDHFLLLYQKK----GQWYEIYDKYQVVQTLDCL RYWK--ATHRSPG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QIHLVQRR----PPSEES----QAFQRQLTALIGY-------DVTDVSNVHDDEL EFTRRGLVT---PRMAEVASRD----------PKLYAMHPW--VTSKP--LPEYLW-KKI AN---NCIFIV-------------IHRSTTSQTIKVSPDDTPGTILQSFFTKMAKKKSL- MDIPE-------SQSEQDFVLRVCGRDEYLVG-E-APIKN-FQ--WV-RHC-LKNGE-EI HVVLDT--PPDP--ALD-----EVRK--EEWP---------------------------L VD----DCTGVTGYHEQ-----------------------------------------LT IHG--KDH---------------------------------------------------- ------------------------------------------------------------ ----ES----VFTVS--------LWDCDRK-FRVKIRGIDIPV-------LPRN---TDL TVFVEANIQHGQQVLCQ-R-RT----SPKPFTE-----EV-LW-NVWLE-F-SIKIKDLP KGALLNLQIYCGKA-PALSSKAS---------AESP--SSES-K-----GKVQLLYYVNL LLIDHR-F----------------LLRRGEYVLHMWQISGKGE-D--QGSFSADKLTSAT NPDKEN---SMSIS-----ILLDNYCH---PIALPKHQP--------TPD---------- ------------------------------------------------------------ -----PEGDRVRAEM--PNQL----RKQLEAII----ATDPLNPLTAEDKELLWHF-RYE SL-KHPKAYPKL-FSSVKWGQQEIVA---KTY---QLLARREVWDQSALDVGLTMQLLDC NFSDENVRAIAVQKL-ES-LEDDDVLHYLLQLVQAVKSEPYHDSALARFLLKRGLR--NK RIGHFLFWFLRSEIAQ------S-----------------------RHYQQRFAVILEAY LRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSL--S---AEKYDVS--------SQVI--- SQLKQKLENLQ--NS----QLPKSFRVPYDPGLKAGAL-A-IEKCKVMASKKKPLWLEFK CADPTAL--SNETI----GIIF--KHGD--DL-RQDMLILQILRIMESIWETESLDLCLL PYGCISTGDKI---GMIEIVKDATTIAKIQ--QSTVGNT-GAFKDEVL--NHWLKEKSPT EE-------------------------KFQAAVERFVY-SCAGYCVATFVLGIGDRHNDN IMITETGNLFHIDFGHILGNYKSFLGIN--KERVPFVLTPDFLFVMGTS--GK--K-TSP HFQKFQ---------------DICVKAYLALRHHTNLLIILFSMMLMT-GMPQLTSKEDI EYIR--DA-LTV-GK-NEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQG------ --------------------------------------------EKHSA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >M_musculus_ENSMUSP00000020890 -------------------MELENYEQPVVLREDNLRRRRRMKPRSA---AGSLSSME-- ------------------------------------------------------------ ---------------------------LIPIEFVLPT-SQRIS-KTPETALLHVAGHGNV EQMK-AQVWLRALETSVA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------AEFYHRLGPDQFLLLYQKK----GQWYEIYDRYQVVQTLDCL HYWK--LMHKSPG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QIHVVQRH----VPSEET----LAFQKQLTSLIGY-------DVTDISNVHDDEL EFTRRRLVT---PRMAEVAGRD----------AKLYAMHPW--VTSKP--LPDYLS-KKI AN---NCIFIV-------------IHRGTTSQTIKVSADDTPGTILQSFFTKMAKKKSL- MNISE-------SQSEQDFVLRVCGRDEYLVG-E-TPLKN-FQ--WV-RQC-LKNGD-EI HLVLDT--PPDP--ALD-----EVRK--EEWP---------------------------L VD----DCTGVTGYHEQ-----------------------------------------LT IHG--KDH---------------------------------------------------- ------------------------------------------------------------ ----ES----VFTVS--------LWDCDRK-FRVKIRGIDIPV-------LPRN---TDL TVFVEANIQHGQQVLCQ-R-RT----SPKPFAE-----EV-LW-NVWLE-F-GIKIKDLP KGALLNLQIYCCKT-PSLSSKAS---------AETP--GSES-K-----GKAQLLYYVNL LLIDHR-F----------------LLRHGDYVLHMWQISGKAE-E--QGSFNADKLTSAT NPDKEN---SMSIS-----ILLDNYCH---PIALPKHRP--------TPD---------- ------------------------------------------------------------ -----PEGDRVRAEM--PNQL----RKQLEAII----ATDPLNPLTAEDKELLWHF-RYE SL-KHPKAYPKL-FSSVKWGQQEIVA---KTY---QLLARREIWDQSALDVGLTMQLLDC NFSDENVRAIAVQKL-ES-LEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLR--NK RIGHFLFWFLRSEIAQ------S-----------------------RHYQQRFAVILEAY LRGCGTAMLQDFTQQVHVIEMLQKVTIDIKSL--S---AEKYDVS--------SQVI--- SQLKQKLESLQ--NS----NLPESFRVPYDPGLKAGTL-V-IEKCKVMASKKKPLWLEFK CADPTVL--SNETI----GIIF--KHGD--DL-RQDMLILQILRIMESIWETESLDLCLL PYGCISTGDKI---GMIEIVKDATTIAQIQ--QSTVGNT-GAFKDEVL--NHWLKEKCPI EE-------------------------KFQAAVERFVY-SCAGYCVATFVLGIGDRHNDN IMISETGNLFHIDFGHILGNYKSFLGIN--KERVPFVLTPDFLFVMGSS--GK--K-TSP HFQKFQ---DCCVTL--QYYGDVCVRAYLALRHHTNLLIILFSMMLMT-GMPQLTSKEDI EYIR--DA-LTV-GK-SEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQG------ --------------------------------------------EKHSA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >C_familiaris_ENSCAFP00000005911 -------------------MEPQGREPRVVLREDHRRRRRRMMP-----------SME-- ------------------------------------------------------------ ---------------------------LIPIEFVLPT-SQRSS-KAPETALLHVAGHGNV EQMK-AQVWLRALETSAA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------ADFYQRLGPDHFVLLYQKK----GQWYEIYDRYQVVQTLDCL RYWQ--LLHRSPG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QIHVVQRR----APSAAT----LAFQRQLTALIGY-------DVTDLSNVHDNEL EFTRRRLVT---PRMLEVAGRD----------PELYAMHPW--VTSKP--LPDYLR-KRI PN---NCVFIV-------------IHRGTTSQTVKVSADDTPGAILRSFFAKMAKKKAL- MGIPE-------GQSERDFVLRVCGRDEYLVG-D-TPLQN-FQ--WV-RQC-LKNGE-EI HLVLDA--PPDP--ALD-----EVRK--EEWP---------------------------L VD----DCTGVTGYHEQ-----------------------------------------LT IHG--KDH---------------------------------------------------- ------------------------------------------------------------ ----ES----VFTVS--------LWDCDRR-FRVKIRGIDIPV-------LPRN---ADL TVFVEANIQHGQQVLCQ-R-RT----SPKLFTE-----EV-LW-NVWLE-F-SIKIKDLP RGALLNLQVYCSKA-PTLSAKAS---------ADAPGAGSEA-R-----GKAQLLYYVNL LLIDHR-F----------------LLRRGEYVLHMWQISGKGE-D--QGSFNADKLTSAT NPDKEN---SMSIS-----ILLDNYCH---PIALPKHRP--------TPD---------- ------------------------------------------------------------ -----PEGDRVRAEM--PNQL----RKQLEAII----ATDPLNPLTAEDKELLWHF-RYE SL-KHPKAYPKL-FSSVKWGQQEIVA---KTY---QLLARREVWDQSALDVGLTMQLLDC NFSDENVRAIAVQKL-ES-LEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLR--NK RIGHFLFWFLRSEIAQ------S-----------------------RHYQQRFAVLLEAY LRGCGTAMLHDFTQQVQVIEMLQKVTIDIKSL--S---AEKYDVS--------SQVI--- SQLKQKLENLQ--NL----NLPESFRVPYDPGLKAGAL-V-IEKCKVMASKKKPLWLEFK CADPTAL--SNETI----GIIF--KHGD--DL-RQDMLILQILRIMESIWETESLDLYLL PYGCISTGDKI---GMIEIVKDATTIAKIQ--QSTVGNT-GAFKDEVL--NHWLKEKCAI EE-------------------------KFQAAVERFVY-SCAGYCVATFVLGIGDRHNDN IMITETGNLFHIDFGHILGNYKSFLGIN--KERVPFVLTPDFLFVMGTS--GK--K-TSL HFQKFQ---DGCLGYLQDYLNDVCVKAYLALRHHTNLLIILFSMMLMT-GMPQLTSKEDI EYIR--DA-LTV-GK-NEEEAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQG------ --------------------------------------------EKHSA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >R_norvegicus_ENSRNOP00000047877 -------------------MELENYEQPVVLREDNLRRRRRMKPRSA---AGSLSSME-- ------------------------------------------------------------ ---------------------------LIPIEFVLPT-SQRIS-KTPETALLHVAGHGNV EQMK-AQVWLRALETSVA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------AEFYHRLGPDQFLLLYQKK----GQWYEIYDRYQVVQTLDCL RYWK--MMHKSPG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QIHVVQRH----VPSEET----LAFQKQLTSLIGY-------DVTDISNVHDDEL EFTRRRLVT---PRMAEVAGRD----------AKLYAMHPW--VTSKP--LPDYLS-KKI VN---NCIFIV-------------IHRGTTSQTIKVSADDTPDTILQSFFTKMAKKKSL- MNIPE-------SQSEQDFVLRVCGRDEYLVG-E-TPLKN-FQ--WV-RQC-LKNGE-EI HLVLDT--PPDP--ALD-----EVRN--EEWP---------------------------L VD----DCTGVTGYHEQ-----------------------------------------LT IHG--KDH---------------------------------------------------- ------------------------------------------------------------ ----ES----VFTVS--------LWDCDRK-FRVKIRGIDIPV-------LPRN---TDL TVFVEANIQHGQQVLCQ-R-RT----SPKLFTE-----EV-LW-NVWLE-F-GIKIKDLP KGALLNLQIYCCKT-PSLSSKAS---------VETP--GSES-K-----GKAQLLYYVNL LLIDHR-F----------------LLRHGGYVLHMWQISGKAE-E--QGSFNADKLTSAT NPDKEN---SMSIS-----ILLDNYCH---PIALPKHRP--------TPD---------- ------------------------------------------------------------ -----PEGDRVRAEM--PNQL----RKQLEAII----ATDPLNPLTAEDKELLWHF-RYE SL-KHPKAYPKL-FSSVKWGQQEIVA---KTY---QLLARREIWDQSALDVGLTMQLLDC NFSDENVRAIAVQKL-ES-LEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLR--NK RIGHFLFWFLRSEIAQ------S-----------------------RHYQQRFAVILEAY LRGCGKAMLQDFTQQVHVIEMLQKVTIDIKSL--S---AEKYDVS--------SQVI--- SQLKQKLESLQ--NS----SLPESFRVPYDPGLKAGTL-V-IEKCKVMASKKKPLWLEFK RADPTVL--SNETI----GIIF--KHGD--DL-RQDMLILQILRIMESIWEAESLDLCLL PYGCISTGDKI---GMIEIVKDATTIAQIQ--QSTVGNT-GAFKDEVL--NHWLKEKCPI EE-------------------------KFQAAVERFVY-SCAGYCVATFVLGIGDRHNDN IMISETGNLFHIDFGHILGNYKSFLGIN--KERVPFVLTPDFLFVMGTS--GK--K-TSP HFQKFQ---DCCVTL--QYYKDVCVRAYLALRHHTNLLIILFSMMLMT-GMPQLTSKEDI EYIR--DA-LMV-GR-SEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQG------ --------------------------------------------EKHSA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >M_domestica_ENSMODP00000020475 -------------------MDLEDHE-PVVLREDHRGRRRRMKPQSA---GISSSSME-- ------------------------------------------------------------ ---------------------------RIPIEFILPT-SHQNT-KATETVILEAAGNCNV EQVK-AQVWMQAMETSTT------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MQFYHQSSPEQFLLLYQKK----GQWYEIYDKYQLIQTLDCV KYWK--ALQKNMG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QIHVVQRQ----PPTEET----REFQQQLNDLIGY-------DVTNMSNVHDDEL EFTRRRLVT---PRMMEVARRD----------PKLYAMHPW--VTSKP--LPTYLL-KKI VN---NCIFIV-------------IHRSTTSQTIKVSADDTPGTILQSFFTKMAKKKSL- MDIPE-------SQSELDFVLRVCGRDEYIVG-E-TPIKN-FQ--WI-RHC-LKNGE-EI HLVLDA--PPDP--GQD-----EVRK--EEWP---------------------------L VD----DCTGVTGYHEQ-----------------------------------------LT ING--KNH---------------------------------------------------- ------------------------------------------------------------ ----ER----VFTLS--------LWDCDQR-FRVKIRGIDIPV-------LPRN---TEL TVFVEANIQHGQQVLCQ-R-RT----TSKPFTE-----EV-LW-NVWLE-F-GIKIKDLP KGAILNLQIYCGKA-TAQSSK-----------AEIS--SFET-K-----GKTQLLYYVNL LLIDHR-F----------------LLRHGEYVLHMWKISGKGE-D--QGSINADKLTSAT NPDTEN---SMSIS-----ILLDNYCH---PIALPKHRP--------TPD---------- ------------------------------------------------------------ -----PEGDRVRGEM--PNQL----RKQLEEII----ATDPLNPLTAKDKELLWHF-RYE SL-KHPKAYPKL-FSSVKWGQQEIVA---KTY---QLLARREAWDQSDLDVGLTMQLLDC NFSDENVRAIAVQKL-ES-LEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLR--NK RIGHFLFWFLRSEIAQ------S-----------------------RHYQQRFAVILEAY LRGCGMAMLEDFTKQVQVIRMLQKVTIDIKSL--S---AEKYDVT--------SQVI--- AQLKQKLENLQ--NS----NLPKNFRVPYDPGLRAGTL-V-IEKCKVMASKKKPLWLEFK CADPTAL--SNETI----GIIF--KHGD--DL-RQDMLILQILRIMGSIWEAESLDLCLQ PYGCISTGDKI---GMIEIVKDATTIAKIQ--QSTVGNT-GAFKDEVL--NHWLKEKCPI EE-------------------------KFQAAVEKFVY-SCAGYCVATFVLGIGDRHNDN IMITETGNLFHIDFGHILGNYKSFLGIN--KERVPFVLTPDFLFVMGTS--GK--K-SSL HFQKFQ---VTCITLSPYHSSDICVKAYLALRQHTNLLIILFSMMLMT-GMPQLTSKEDI EYIR--DT-LTV-GK-NEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQG------ --------------------------------------------EKHSA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >G_aculeatus_ENSGACP00000025368 -----------------EQNQLSDEE-PKILREET-RRRRRKKAIS----SSSCPSMD-- ------------------------------------------------------------ ---------------------------QISVEFVLPT-AARGG-SGTEILLLEVAGNWTV EQVK-AQVWLKAVTLNLC------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------PDFYQRFSPDHCILLYQKK----GNVCEIYDKHQVFQTLDCI RYWRAKALKKDVG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----RIQLVPRP----QPADDS----LQYQSYLNYLIGY-------DVTDVSNVHDDEL EFTRRKLLT---PRRIELTDRD----------AKLYSMDPW--VARKP--LPEHLL-SKV SN---AHVLLV-------------IHISTASQTIKVSLQDTPAQVLASFFAKTANKRVL- LGIPQ-------NMCEADFVLRVCGREEYLYG-D-KPLQD-FN--WI-RQC-LKNGD-EI HLVLES--PPDT--DLD-----LVQK--EDWA---------------------------Q VD----DCTGVAGTHEQ-----------------------------------------LT IDE--KDH---------------------------------------------------- ------------------------------------------------------------ ----ER----VFTVS--------MWDCNRK-FRVKVLGIDIPF-------LPKI---PEF IVFIEASIFHGQQLLAQ-E-RT----CSKNFSE-----EV-LW-NCWLE-F-NIKIRDLP KGARLNLQVVCGKQPPTANSKGA-----------------SG-K-----TKSRLLYYVNL LLIDHR-S----------------LLRQGEFILHMWKMPEKSE-ES-SSSINADKLTSAT NPDKAS---AMAVA-----ILLDKYCY---PVVLPKSRNLVCRDAG-GEEV--------- ------------------------------------------------------------ -----EGGERGQREM--PNHL----KKQFAAIV----ATDPLHPLSPEDKELLWHF-RHE CM-RDPRAYPKL-LGSVKWGRQEDVL---ATH---RLLERSSAWDSSGLDVGLAMQLLDC HYSDAQVRSMAVRKL-ET-LEDDDVLRYLLQLVQAVKFEPYHDSALVRFLLKRALR--SK RIGHFLFWFLRSEIAQ------S-----------------------MHYQQRYAVLLEAY LRGCGEDMLQDFRKQVEMTEALQKVTREMKAM--S---ADKCDIT--------AQVV--- FQLRQKLETLQ--SS----GLPESFRVPYDPGLRAGAL-M-IEQCKVMASKKKPLWLQFK RADQTTL--SRDPI----GIIF--KEGD--DL-RQDMLILQILLIMESIWETETLDLCLL PYGCISTGNRI---GMIEIVKDATTIANIQ--QSVMGST-GAFKDEIL--SQWLRDKCVS ED-------------------------KFQQAVERFLY-SCGGYCVATYVLGIGDRHNDN IMITESGNLFHIDFGHILGNYKSFMGIS--KEWVPFVLTPDFLYVMGTT--GK--K-SSP HFQKFQ---------------DVCVKAYLALRHHTNLLIILFSMMLMTAGMPQLTSKEDI EYIR--EA-LTV-GR-SEDEAQRHLLDQIEICREKGWMVQINWFVHLVLGIKQGV----- --------------------------------------------EKRST----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >G_gallus_ENSGALP00000013101 -------------------MELGDYEQPVVMREENKRRRRRMKPHCT---SSNLSSME-- ------------------------------------------------------------ ---------------------------LISIEFILPT-SNKHT-KVPEMMLLEIAGNCTV EQMK-AQIWMRAIEMSQT------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------TDFYHTFTPDQFVLQYQKK----GQWYEIYDKHQLLQTLDCI LYWK--VLQKKVG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----KIYVVQKQ----KPSEEV----QEFQRQLNDLIGY-------DVTDVSNVHDDEL EFTRRRLVT---PRMIEVACRD----------PKLYAMHPW--TTSKP--LPEYLF-KKI TN---NNIFII-------------IHRGTTSQKIKVSIDDTPDMILHSFFTKMAKKKSL- MDIPE-------DHSELDFVLRICGRDEYITG-D-TPIKD-FH--WI-RQC-LKNGE-EI HLVLDN--PPDP--SED-----EVQK--EEWP---------------------------L VD----DCTGVTGYHEQ-----------------------------------------LT IDG--KDH---------------------------------------------------- ------------------------------------------------------------ ----ER----VFTIS--------LWDCNRK-FRVKIIGIDIPV-------LPRN---TDL TVFVEANIQHGQQLLSQ-R-RT----SSKPFTE-----EV-LW-NIWLE-F-DIKIKDLP KGALLNLQIYCGKA-QGLSTKTN------LQSHESP--NSDS-K-----CKTQLLYYVNL LLIDHR-F----------------LLRSGEYVLHMWKIPGKGE-E--QGSINADKLTSAT NPDKEN---SMAIS-----IVLDKYCH---PIALPKHRI--------TSD---------- ------------------------------------------------------------ -----SQGDRTRAEM--PNQL----RKQLEEII----ATDPLNPLSPEDKELLWHF-RYE SI-KHPKAYPKL-LSSVKWGQQEIVA---KTY---QLLAKKEVWDQSTLDVGLTMQLLDC NFSDENVRAMAVQKL-ES-LEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLR--NK RIGHFLFWFLRSEIAQ------S-----------------------MHYQQRFAVILEAY LRGCGKAMLHDFMKQVQVIELLHKVTMEIKSV--S---AEKYDVT--------SQVI--- AQLRQKLEKLQ--GS----KLPESFRVPYDPGLRAGPL-V-IEKCKVMASKKKPLWLEFK CADPTAL--SNETI----GIIF--KHGD--DL-RQDMLILQILRIMESIWEAESLDLCLL PYGCISTGNKI---GMIEIVKDATTIAKIQ--QSTVGNT-GAFKDEIL--NQWLKDRCVI EE-------------------------KFQAAVERFVY-SCAGYCVATFVLGIGDRHNDN IMITETGNLFHIDFGHILGNYKSFLGIN--KERVPFVLTPDFLFVMGTS--GK--K-TSL HFHKFQ---------------DVCVKAYLALRHHTNLLIILFSMMLMT-GMPQLTSKEDI EYIR--DA-LTV-GK-SEEDAKKHFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGV----- --------------------------------------------EKHSA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >T_guttata_ENSTGUP00000003158 -------------------MELGDHEQPVVMRDENKRRRRRMKPHCA---SSSFSSME-- ------------------------------------------------------------ ---------------------------LISIEFILPT-SNKHT-KAPETMLLEIAGNCTV EQMK-AQIWMRAIETSQT------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------TDFYHAFTPDQFILQYQKK----GQWYEIYDKHQVLQTLDCI LYWK--VLQKKVG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----KIYVVQKQ----TPSEEV----QELQRQLNDLIGY-------DVTDVSNVHDDEL EFTRRRLVT---PRMIEVACRD----------PKLYAMHPW--TTSKP--LPEYLF-KKI IN---NNIFII-------------IHRGTTSQKIKVSIDDTPDMILHSFFTKMAKKKSL- MDIPE-------DHSELDFVLRICGRDEYITG-D-TPIKD-FH--WI-RQC-LKNGE-EI HLVLDN--PPDP--NED-----EVQK--EEWP---------------------------L VD----DCTGVTGYHEQ-----------------------------------------LT IDG--KDH---------------------------------------------------- ------------------------------------------------------------ ----ER----VFTIS--------LWDCNRK-FRVKIIGIDIPV-------LPRN---TDL TVFVEANIQHGQQLLSQ-R-RT----SSKPFTE-----EV-LW-NIWLE-F-DIKIKDLP KGALLNLQIYCGKA-QGPSAKTN------LQSHESS--NSDA-K-----CKTQLLYYVNL LLIDHR-F----------------LLRSGEYVLHMWKIPGKGE-E--QGSINADKLTSAT NPDKEN---SMAIS-----IVLDKYCH---PIALPKHRI--------SSD---------- ------------------------------------------------------------ -----PQGDRTRAEM--PNQL----RKQLEEII----ATDPLNPLSPEDKELLWHF-RYE SI-KHPKAYPKL-LSSVKWGQQEIVA---KTY---QLLAKKEAWDQSTLDVGLTMQLLDC NFSDENVRAMAVQKL-ES-LDDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLR--NK RIGHFLFWFLRSEIAQ------S-----------------------MHYQQRFAVILEAY LRGCGKAMLHDFMKQVQVIELLHKVTMEIKSV--S---AEKYDVT--------SQVI--- AQLRQKLEKLQ--GS----KLPESFRVPYDPGLRAGAL-V-IEKCKVMASKKKPLWLEFK CADPTAL--SNETI----GIIF--KHGD--DL-RQDMLILQILRIMESIWEAESLDLCLL PYGCISTGNKI---GMIEIVKDATTIAKIQ--QSTVGNT-GAFKDEIL--NQWLKERCMI EE-------------------------KFQAAVERFVY-SCAGYCVATFVLGIGDRHNDN IMITETGNLFHIDFGHILGNYKSFLGIN--KERVPFVLTPDFLYVMGTS--GK--K-TSL HFHKFQ---------------DVCVKAYLALRHHTNLLIILFSMMLMT-GMPQLTSKEDI EYIR--DA-LTV-GK-SEEDAKKHFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGV----- --------------------------------------------EKHSA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >A_carolinensis_ENSACAP00000014629 -------------------MELEVNEQPVVMRDDNKRRRRRMKPYCT---ASSLSASE-- ------------------------------------------------------------ ---------------------------LITIEFVLPT-SN---------MLIDIASNCTV EQMK-AQIWMRAIERNQN------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------SDYYHTFTPDQFVLQYQKK----GQWYEIYDKHQIIQTLDCI LYWK--VLQKKVG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----KIHVIQKQ----KPTKEV----QEFQKQLNYLIGY-------DVTDISNVHDDEL EFARRRLVT---PRTIEVSCRD----------PKLYSLHPW--TTSKP--LPDYML-SRI VN---NSIFIN-------------IHRGTTSQKIKVAIDDTPDTILQSFFTKMAKKKSL- MNIPE-------DHNELDFVLRVSGRDEYIVG-E-TPIRN-FH--WI-RHC-LKNGD-EI HLVLDD--PPDP--NQD-----EVQK--EEWP---------------------------L VD----DCTGVSGYHEQ-----------------------------------------LT IDG--KDH---------------------------------------------------- ------------------------------------------------------------ ----ER----VFTIS--------LWDCNRK-FRVKIIGIDIPV-------LPRN---TDL TVFVEANIQHGQQLLSQ-K-RT----TAKPFTE-----EV-LW-NIWLE-F-DIKIKDLP KGALLTLQVYCGKA-PASSTKAN------LQPHDSP--SPDS-K-----CKTQLLYYVNI LLIDHR-S----------------LLRTGDYVLHMWKISGKGE-E--QGSINADKLTSAT NPDKEN---SMAIS-----IVLDKYCH---PVALPKHKI--------AAD---------- ------------------------------------------------------------ -----LQGDRARAEM--PNQL----RKQLEEII----ATDLLNPLTPEDKELLWHF-RYE SI-KHPKAYPKL-LSSVKWGQQEVVT---ETY---QLLAKRDAWDLSTLDVGLPMQLLDC NFSDENVRAMAVQKL-ES-LDDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLR--NK RIGHFLFWFLRSEIAQ------S-----------------------MHYQQRFAVILEAH LRGCGKAMLQDFLRQVQVIELLQKVTMEIKSL--S---AEKYDVT--------PQVI--- TQLKQKLEKLQ--DC----KFPECFRVPYDPGLKAGAL-V-IEKCKVMASKKKPLWLEFK CADPTSL--SNETI----GIIF--KHGD--DL-RQDMLILQILRIMESIWEEESLDLCLL PYGCISTGNKI---GMIEIVKDATTIAKIQ--QSTVGNT-GAFKDEIL--NQWLKEKCVI EE-------------------------KFQTAVERFVY-SCAGYCVATFVLGIGDRHNDN IMITEAGNLFHIDFGHILGNYKSFLGIN--KERVPFVLTPDFLFVMGTS--GK--K-TSP RFQNFQ---------------DICVRAYLALRKHTNLLIILFSMMLMT-GMPQLTSKEDI EYIR--DA-LTV-GK-NEEDAKKYFLDQIEVCRDKGWTVQFNWFIHLVLGIKQGV----- --------------------------------------------EKHSA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >A_carolinensis_ENSACAP00000013119 ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SIQVDFLLPT-GI--------YLTLSVSCNATL GTIK-QLVWHHAQCEPFF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HML---SDPESYVFTCINQ---TAERQELEDEQRRLCDIQPF --LP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VLRLVARE-----GDRVK----KLISSQISLLIGK-------GLHEFDSLGDLEV DDFRVKMQH---FCEERAARRQ-Q---LSWKAWMEYSFPVQ--LEPLA-NGLGGRSLLQF PN---KNIF--------------------ESFTFQISPKEYPATLMSYAIKKQATVFRH- ---QK-------INSPEDYALQINGKYEYLYG-N-HPLYQ-FQ--YI-RDC-LCRGL-LP HLTMVH--ASSI--SAL-----WE----EQTN---------------------------G IS----YPIKAA----------------------------------------------SK APPVPKK----------------------------------------------------- ------------------------------------------------------------ -----K----KLFLST-------VYTRINP-WSCCLCR-SSIL-------PCLP-----F QLVVQAGLYHGHEMLCK-MVSS----SEVSVCS-----EP-VW-GQRLE-F-EINVCDLP RMARLCLALYAVVE----KAKKA--RSTKKNNPVVHRKAKTG-E-----QVDCPIAWVNV MLFDFR-D----------------QLKTGECCLPMWSSFP--D-E--KGELLNPMGTVQT NPNTES---AASLV-----IRFPTISS--NPLYYPTFEQ--------VRKS--------- -----------------------------------------------LL-NIK-L----- -----VNVFNISLYF--GAKF----VNTLKEIL----ERRSHTDLYEHEKDLVWKM-RHQ IRDQFPHALAKL-LVVTKWNKHEDVA---QMI---YLLQSW-----PELPVLNALELLDF SFPDRYVGAFTVNSL-KK-LTSK------------------------------------- -------------------------------------------------MQRCGFLVLVF C--------------------LLCFEEFLIFD--------------Q------SK----- QVLH-ARACSS--FL----TACFTRKSPLIIIIIIIIIISSVELCTFMDSKMKPLWIVFN NEDAG-----GGHV----GVIF--KNGD--DL-RQDMLTLQMIQLMDILWKKEGLDLRMT PYG-FSTGDKT---GLIEVVMDSDTIANIQLNKSNMAAT-AAFNKDAL--LNWLKSKN-P GD-------------------------ALDRAIEEFTL-SCAGYCVATYVLGIGDRHSDN IMIRENGQLFHIDFGHFLGNFKTKFGIN--RERVPFILTYDFVHVIQQG--KT--N-NSE KFERFR---------------EYCERAYMILRCHGLLFLHLFALMKAA-GLPELSCSKDI QYLK--DS-LAL-GK-TDEEARRHFQLKFNEALRESWKTKVNWLAHNVS----------- --------------------------------------------KDNRQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >X_tropicalis_ENSXETP00000013019 -------------------MELDSYEQPVVLRDENQRRRRRMRPHSA---TSNMFPME-- ------------------------------------------------------------ ---------------------------QIPIEFILPT-SNRCS-KVQETMLLEVAGNCSV EQMK-AQIWMHAIEKSHN------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------SDFYQRLTPDQFLLQYQKK----GQWYEIYDKHQVIQTLDCI MYWK--VLQKTVG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----KIHIVQKE----KIPEEM----IEYQKTLNYLIGY-------DVTDVSNVHDDEL EFTRRRLVT---PRMIELSRRD----------ARLYSMDPW--VTCKS--LPEYLC-QRI IS---NSIFII-------------IHKGMTSHTIRVSIDDTPDVILHSFFTKMAKKKSL- LDISE-------ENSELDFVLRVCGRDEYIIG-N-APIKD-FH--WI-RQC-IKNGQ-EI HLVLEK--PPDP--LMD-----EVQK--EQWP---------------------------L VD----DCTGVTGYHEQ-----------------------------------------LT IEG--KDH---------------------------------------------------- ------------------------------------------------------------ ----EK----IFTIS--------LWDCNRK-FRVKIIGIDIPV-------LPKN---TEL IAFVEANIQHGQQVLSQ-R-RT----TCKPFTE-----EV-LW-NSWLE-F-DIKIKDLP KGALLNLQIFCGKA-PTASNKSI------VQSPEST--ASDS-K-----CKNQLLYYVNL LLIDHR-F----------------LLRQGEYVLHMWKIPGKGE-E--QGSINADKLTSAT NPDKET---SMAIS-----ISLDKYCH---PVALPKHKL--------VCD---------- ------------------------------------------------------------ -----PELERPRTEM--PNQL----RKQLEEII----ATDPLHPLTPEDKELLWHF-RSE IV-KHPEAYPKL-LSSVKWGQQEMVA---KTY---QLLSKREAWDDCSLDVGLTIQLLDC NFSDENVRAMAVQKL-ES-LQDDDVLHYLLQLVQAVKFEPYHDSALSRFLLKRALQ--SK RIGHFLFWFLRSEIAQ------S-----------------------MHYQQRFAVILEAY LRGCGKAMLDDFTRQVQVTEILHKVTMEIKSV--S---AEKYDVT--------SQVI--- TQLRQKLEKLQ--NSKLPDKLPDSFRVPYDPGLRAGSL-V-VEKCKVMASKKKPLWLEFK CSDTTAL--SNETI----GIIF--KHGD--DL-RQDMLILQILRIMGSIWEAESLDLCLL PYGCISTGNKI---GMIEIVKDATTIAQIQ--QSTVGNT-GAFKDEVL--SQWLKEKCPI EE-------------------------KFSAAVERFVY-SCAGYCVATFVLGIGDRHNDN IMVTESGNLFHIDFGHILGNYKSFLGIN--KERVPFVLTPDFLYVMGTS--GK--K-TSQ YFNKFQ---V-CILQTQQKKEDVCVKAYLALRHHTNLMIILFSMMLMT-GMPQLTSKEDI EYIR--DS-LTV-GK-NEESAKKHFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGV----- --------------------------------------------EKHSA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >C_intestinalis_ENSCINP00000014231 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------YEKVWEHELLLTYTID----GKTYEICDMHQTFQTLRVI NMWTKTGL---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----KGTLDVRH-----LTNEE----RLFNLTLGSLMGVIWGKYGSMVKHNTAVTDDEV YVTRRKLTN---VRRRALRSRF----------PSTYSMEPI--LDHTT--PPTHVK-ANF QE---DETITVC-----------IYGPSKSSTTMSVGVYDPPSKIMEDFFESLTPARKIA FGIPE-------EAKAPDYVLKVCGMCDYIWG-P-HEIMD-FV--YI-RHC-VARRR-EP QLALCV--PPND--AED-----EVLSVHDPWF---------------------------F VD----DSTGVTENHQQ-----------------------------------------LT LVGCKKNH---------------------------------------------------- ------------------------------------------------------------ ----TE----IVAFS--------LWDMTRK-FRIKVLGVDYLT-------PENETVGTPD ELYVEFSLYSGRQRLAE-PVRT----KPVASNA-----DL-RW-YTSLE-F-DILLRNVP KEARLNANIIGIFRTKSVKVKTG-----------IKSVSSNG-------DQHVILRWANM QLLNHRLS----------------VLCTGRHAFKTWPMSYSED-----VSVETHTGTTAP NDGVESTSSTAEIH-----FELDSYMH---PVVFPNGGW--------KTSN--------- ------------------------------------------------------------ -----PEDQAPDPIH--GSSD----WKKLEEII----QSDTLTELTLEDKALLKKY-RSY CR-GRANSLPKV-LQAVDAASLDSVV---DMH---ALLNKW-----PALSVEVTLELLDS QYEDEKVRSLAVKTL-KC-LSNTKLHAYLLQLTQVLKFEPYHDSALARFLLTRALQ--SK RIGHYFFWFLRSEI-E------N-----------------------PHVSQRYSILLEAY LRGCGSNMLKEFSKQCAVTNTLKNFSSLVRSL--YIFISMKLSKN--------SNSGLKT EILREQLARI---------SLPETFKAPFDPRITLGRL-M-AEKSKIMDSKKKPLWLEFE NADENVINESTSVI----RIIF--KQGD--DL-RQDMLTLQMLSLMGQLWNEEGLDLHLL PYGCLSTGLQV---GIIQIVPNATTVARIQ--KESGGLIRGTFKDEVL--KKWLERKNPT TD-------------------------RMNSAVETFML-SCAGYCVATYVLGIGDRHNDN IMVTESGNLFHIDFGHFLGNTKRFYGIQ--RERVPFVLTPDFVHVMGTE--------DGE LFQRFM---------VSFLYFDTCVLAYLVIRRHAPLFINLFHMMKST-GIPELNSVRDI RYLQ--NASLVL-DK-TEHEASQHFLSEIAGVLRKNWTVQVNWLMHRLVHSG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >O_latipes_ENSORLP00000011853 -------------------IQVSDEE-PEVPREEC-RRRRRKKAIT----SSSCVSMD-- ------------------------------------------------------------ ---------------------------QITIEFVMPS-AARSG-SGPDILTLDVAGNWTV EQVK-AQVWMKAVTLNLC------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------PDFYQRLSPDHCILLYQKK----GTVCEIYDKHQVFQTLDCI PYWR--ALKKGVG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----RIQMVTRP----QLSEES----LQYQRYLNCLIGY-------DVTDVSNVHDDEL EFTRRKLLT---PRRIELSDRD----------PKLYSMDPW--VTRKP--LPEHLL-SKV NN---SHILVV-------------IHIGMVSQTIKVSINDTPSQVLASFFAKTANKRVL- LGIPD-------DVCEADFVLRVCGREEFLYG-E-KPLQN-FN--WI-RQC-LKNGE-EI HLLLEK--PPDP--ELD-----VVQK--EDWA---------------------------Q VD----DCTGVAGTHEQ-----------------------------------------LT IDE--KDH---------------------------------------------------- ------------------------------------------------------------ ----ER----VFTIS--------MWDCNRK-FRVKVLGIDIPT-------LPKV---PEL VVFIEASIFHGQQLLAQ-E-RT----TSKTFNE-----EV-LW-NCWLE-F-NIKIKDLP KGARLNLQVICGKPTQTPASKGSSHYDN---SAGTG--SVEG-K-----TKNRLLFYVNL LLVDHR-S----------------LLRQGEFILHMWKMPEKSD-ES-SSSINADKLTSAT NPDKSS---SMAVA-----ILLDKYCY---PVVLPKSRD-VGRDSGAGEEM--------- ------------------------------------------------------------ -----EGGERGQREM--PNHL----KKQFEAIV----STDPLHPLSPEDKELLWHF-RQE CM-RDPRAYPKL-LGSVKWGKQEDVL---ATH---RLLERSNAWDTSGLDVGLAMQLLDC HYSDSHVRSMAVRKL-ET-LEDDDVLRYLLQLVQAVKFEPYHDSALVRFLLKRALR--SK RIGHFLFWFLRSEIAQ------S-----------------------MHYQQRYAVLLEAY LRGCGESMLQDFRKQVEMTMALQKVTRDIKAI--A---ADKYDVS--------AQVV--- FQLRQKLETLQ--SS----GLPETFRVPYDPGLRAGAL-L-IEQCKVMASKKKPLWLQFK RADPTTL--SKDPI----GIIF--KDGD--DL-RQDMLILQILLIMESIWETECLDLCLL PYGCISTGNKIGNAGMIEIVKDATTIANIQ--QRVVGST-GAFKDEIL--HQWLRDKCVS ED-------------------------KFQQAVERFLL-SCGGYCVATYVLGIGDRHNDN IMITESGNLFHIDFGHILGNYKSFMGIS--KEWVPFVLTPDFLYVMGTS--GK--K-SSP HFLKFQ---SAAPATRSRISGDVCVKAYLALRHHTNLLIILFSMMLMT-GMPQLTSKEDI EYIR--EA-LTV-GR-SEEEAQRHLLDQIEICREKGWMVQVNWFVHLVLGIKQGV----- --------------------------------------------EKRST----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >T_nigroviridis_ENSTNIP00000009686 -------------------IQLSDEDLQGVPADHS-RRRRRKKAIS----SASRSSMD-- ------------------------------------------------------------ ---------------------------QISVEFVLPS-GARGK-SGSDKLLLDVAANWTV EQVK-TQVWLRAVTLNVC------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------PDFYQRFSPDQCILLYQKK----GSVCEIYDKQQVFQTLDCV CYWK--ALKKDVG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----RIQLVLRP----QQLDES----RQYQRYLNYLIGY-------DVTDVSNVHDDEL EFTRRKLLT---PRRIELADRD----------PKLYSMDPW--VTGKP--LPEHLL-SKV SN---GYILAV-------------IHIGTVSQTIKVCIQDSPAQVLASFFAKTSNKRVL- LGIPE-------NVCEADFVLRVCGREEYLYG-D-KPLQD-FN--WI-RQC-LKNGE-DI HLVLES--PPNP--DLD-----LVQK--EDWA---------------------------Q VD----DCTGAAGTHEQ-----------------------------------------LT IDG--KDH---------------------------------------------------- ------------------------------------------------------------ ----ER----VFTIS--------MWDCNRR-FRVKVLGIDIPS-------LPKI---PDF VVFVEASIFHGQQLLAQ-E-RT----SSKTFTE-----EV-LW-NCWLE-F-NIKIKDLP KGARLSLQVVCRKQAQTPNSKDS--------AASPG--SHDG-K-----AKSRLLYYVNL LLVDHR-S----------------LLRQGEFILHMWKMPEKSE-ESGSGSVNADKLTSAT NPDRVS---SMAIA-----VLLDKYCC---PVVLPKSRA----ARGGGEEA--------- ------------------------------------------------------------ -----AGGERGRREM--PNHL----KKQFAAIV----ATDPLHPLSPEDKELLWHF-RHE CT-RDPRAYPKL-LSSVRWGRQEDVS---ETH---RLLERSSAWDSSRLDVGLALQLLDC HFSDAQVRSMAVRKL-ET-LEDDDVLRYLLQLVQAVKFEPYHDSSLVRFLLKRALR--SK RIGHFLFWFLRSEIAQ------S-----------------------MHYQQRFAVLLEAY LRGCGEDMLQDFRKQVEITEALQKVTREIKAV--S---AEKYDIT--------AQVV--- FQLRQKLEALQ--SS----GLPEDFRVPYDPGLRAGAL-L-IEQCKVMASKKKPLWLQFK RADGSTL--SKDPI----GIIF--KDGD--DL-RQDMLILQILLIMESIWETESLDLCLL PYGCISTGNRI---GMIEIVKDATTIANIQ--QSVVGST-GAFKDEIL--CQWLRDKCVS ED-------------------------KFQQAVERFLY-SCGGYCVATYVLGIGDRHNDN IMITESGNLFHIDFGHILGNYKSFMGIS--KEWVPFVLTPDFLYVMGTS--GK--K-SSP NFQKFQ---------------NVCVKAYLTLRHHTNLLIILFSHFLFA-GMPQLTSKEDI EYIR--EA-LTV-GR-SEDEA-RHLLDQIEICREKGWMVQINWFVHLVLGIKQGV----- --------------------------------------------EKRSI----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >D_rerio_ENSDARP00000002818 -----------------MEQQASDDEPPVVRREENKRRRRRMKAFT----SASAVSME-- ------------------------------------------------------------ ---------------------------HIAVEFVLPT-TNKNS-KTLDTLQLDVTGNWTV EQVK-VQLWHRAVTSKLC------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------PEFYQKYSPDYCILLYQKK----GNWYEIYDKQQVFQTLDCI RYWK--ALRKDVG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----KIHLVVRQ----QPAEDS----LQYQRFLNHLIGY-------DVTDVSNVHDDEL EFTRRKLLT---PRKIELSDRD----------PNLYSMDPW--MTTTP--MPEYLL-SKI SN---NHILMV-------------IHKETTSQTIKVSIDDTPVQVLQSFFAKITNKRAL- LGISE-------DVSESDFVLRVCGREEYLYG-N-NAIKD-FH--WI-RQC-LKNGE-EI HLVLEH--PPNP--EQD-----VVQK--EDWS---------------------------Q VD----DCTGVAGTHEQ-----------------------------------------LT ITE--KDH---------------------------------------------------- ------------------------------------------------------------ ----EK----VFTIS--------LWDCNRK-FRVKILGIDIPV-------LPRN---SEL IVFVEASIFHGQQLLAQ-E-RT----SSKPFTE-----EV-IW-NTWLE-F-NIKIKDLP KGARLSLQVSCGKA-QTQTSKET-----------------EC-K-----NKSRLLYYVNL LLVDHR-S----------------LLRQGEFILHMWKMPEKSE-D--NSSVNADKLTSAT NPDKNN---SMAVA-----ILLDKYCY---PVALPKSKD--------SPD---------- ------------------------------------------------------------ -----IEGERGQREM--PNHL----RKQFEQII----ATDPLHPLTSEDKELLWHF-RQE CM-RDPKAYPKF-LSSVKWGKQEAVA---ITH---YLLERSTIWDRSVLDVGLVLQLLDC HFSDENVRTIAVRKL-ET-LGDDDVLRYLLQLVQAVKFEPYHDSALARFLLKRALR--SK RIGHFLFWFLRSEIAQ------S-----------------------MHYQQRYAVILEAY LRGCGEEMLQDFRKQVEITEALQKVAREIKQI--S---AEKYDIS--------AQVV--- FQLRQKLEGLQ--VL----GLPDSFKVPYDPGLRAGAL-V-IEQCKVMASKKKPLWLQFK RADPTTL--SSDTI----GIIF--KDGD--DL-RQDMLILQILLIMESIWELESLDLSLL PYGCISTGNKI---GMIEIVKDATTIANIQ--QSTVGNT-GAFKDEIL--SQWLREKCVN ED-------------------------KHQQAVDRFVF-SCGGYCVATYVLGIGDRHNDN IMITETGNLFHIDFGHILGNYKSFLGIS--KERVPFVLTPDFLYLMGTT--GK--K-SSP NFLQFQ---------------NVCLKAYLALRHHTNLLIILFSMMLMT-GMPQLTSKEDI EYIR--EA-LTV-GR-SEDEAKQHFLDQIEICRDKGWTVQFNWFLHLVLGIKQGV----- --------------------------------------------EKRSA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >O_cuniculus_ENSOCUP00000004241 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------LHEFDALKDPEV NEFRRKMRK---FSEEKIQSLV-G---LSWIDWLKQTYPPE--HDPSS-LENLED---KL YG---GKLIVA----------V-HFENSQDVFSFQVSPNMNPIKINELAIQKRLTIHGK- ---ED-------EASPYDYVLQVSGRVEYVFG-D-HPLIQ-FQ--XX-XXX-XXXXX-XP HFILVE--CCKI--KKM-----YE----QEMI---------------------------A IE----AAINRNSS--------------------------------------------NL PLPLPPK----------------------------------------------------- ------------------------------------------------------------ -----K----TRITSH-------VWENNNP-FQIVLVKGNKLN-------TEET-----V KVHVRAGLFHGTELLCK-TIVS----SEISGKN-----DH-IW-NEPLE-F-DINTCDLP RMARLCFAVYAVLD----KVKTK--KSTKTINPSKYQTIRKA-G-----KVHYPVAWVNT MVFDFK-G----------------QLRSGDVILHSWSSFP--X-X--XXXXXXXXXXXXX XXXXXX---XXXXX-----XXXXXXXX--XXXXXXXXXX--------IIEK--------- -----------------------------------------------AA-EIA-S----- -----NDSANVSSRG--GKKF----LAVLKEIL----DRDPLSQLCENEMDLIWTL-RQD CRENFPQSLPKL-LLSIKWNKLEDVA---QLQ---ALLQIW-----PKLPPREALELLDF NYPDQYVREYAVGCL-RQ-MSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALA--NR RIGQFLFWHLRSEV-H------I-----------------------PAVSVQFGVILEAY CRGSV-GHMKVLSKQXXXXXXXXXXXXXXXXX--A---VNRD--A-K------VN----- EAMHPCLKQNA--YR----EALSDLQSPLNPCVILSEL-Y-VEKCKYMDSKMKPLWLVYN NKVFG-----EDSV----GVIF--KNGD--DL-RQDMLTLQMLRLMDLLWKEAGLDLRML PYGCLATGDRS---GLIEVVSTSETIADIQLNSSNVAAA-AAFNKDAL--LNWLKEYN-S GD-------------------------DLDRAIEEFTL-SCAGYCVASYVLGIGDRHSDN IMVKKTGQXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXX--XX--X-XXX XXXXFR---------------QCCEDAYLILRRHGNLFITLFALMLTA-GLPXXXXXXXX XXXX--DS--AL-GK-SEEEALKQFKQKFDEALRESWTTKVNWMAHTVR----------- --------------------------------------------KDYRS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >T_rubripes_ENSTRUP00000029189 -------------------AQLSDEDSAIVTGDHSRRRRRRRKAVG----SAPHSSMD-- ------------------------------------------------------------ ---------------------------QISVEFVLPA-AARCK-SGSDKLLLDVAANWTV EQVK-TQVWLRAVTLNIC------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------PDFYQRFSPDQCILLYQKK----GSVCEIYDKHQVFQTLDCV CYWR--ALKKEVG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----RIQLVLRP----QPSEES----LQYQRYLNYLMGY-------DVTDVSNVHDDEL EFTRRKLLT---PRRLELMERD----------PKLYSMDPW--VTCKN--LPEHLL-SKV SN---GSILVV-------------IHVSTVSQTIKVSIGDSPAQVLTSFFAKTSNKRVL- LGIPE-------NLSETDFVLRVCGREEYLYG-D-KPLQN-FN--WV-RQC-LKNGE-EI HLVLET--PPNP--DLD-----LVQK--EDWA---------------------------Q VD----DCTGVAGTHEQ-----------------------------------------LT IDG--KDH---------------------------------------------------- ------------------------------------------------------------ ----ER----VFTIS--------MWDCNRK-FRVKVLGIDIPS-------LPKI---PDF LVFVEASIFHGQQLLAQ-E-RT----SSKTFTE-----EV-LW-NCWLE-F-NIKIKDLP KGARLSLQVVCRKQPQTLNSKGGSAQQDSPAAAAAG--GHDG-K-----TKSRLLYYVNL LLVDHR-S----------------LLRQGEFILHMWKMPEKSD-ES-SSSINADKLTSAT NPDRAS---SMAVA-----ILLDKYCY---PVVLPKSRAASREARGGVEEA--------- ------------------------------------------------------------ -----QGGERGQREM--PNHL----RKQFAVIV----RTDPLHPLSPEDKELLWHF-RHE CT-RDPRAYPKL-LSSVSWGKQEDVL---ETH---RLLERSSAWDSSGLDVGLAMQLLDC HFSDAQVRSLAVRKL-ET-LEDDDVLRYLLQLVQAVKFEPYHDSSLVRFLLKRALR--SK RIGHFLFWFLRSEIAQ------S-----------------------MHYQQRYAVLLEAY LRGCGEDMLQDFRKQVETTEALQKVTREIKTV--S---ADKYDIT--------AQVV--- FQLRQKLEALQ--SS----GLPEDFRVPYDPGLRAGAL-L-IEQCKVMASKKKPLWLQFK RADSTTL--SKDPI----GIIF--KDGD--DL-RQDMLILQILLIMESIWETESLDLCLL PYGCISTGNRI---GMIEIVKDATTIANIQ--QSVVGST-GAFKDEIL--CQWLRDKCVN ED-------------------------KFQQAVERFLH-SCGGYCVATYVLGIGDRHNDN IMITESGNLFHIDFGHILGNYKSFMGIS--KEWVPFVLTPDFLYVMGTS--GK--K-SSP NFQKFQ---------------SCCKHS----RH----------VCTAT-HPPPLV----- -----------------------QMLDQIEICREKGWMVQINWFVHLVLGIKQGV----- --------------------------------------------EKRSA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >D_rerio_ENSDARP00000054650 ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EPLQIKLPGQCSV HQLR-VRLCMLAQENNRI------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------SEPFALLDPERYSLLYHKE----EEWYEIYDDFQVLQTLDA- -PWF--QGTDGLQ----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----TVFVTVLA--QKSASEER----VYFQHVLNELIGY-------DLDSSNANRLGEL AYTRRKFAT---PRTQELKKRD----------LIAYATEPW--TTSIV--LPNDQQ-GYF QR---TLSVTL--------------YYNGSNLSIKADLTQKPSDILKIFWESLPKGSLP- -----------IESWTSDHVLKVCGREEFLSG-D-FQLSN-YL--WV-RHC-LKNSL-EL HLSVVA--ISSL--PDD-----TVST--EYWP---------------------------L VD----SLTGLSSSHEE-----------------------------------------LC LKK--KEV---------------------------------------------------- ------------------------------------------------------------ ----ED----IVLIS--------LWDCERK-FRVKLLGFDIPD-------LPSK---VPS LVYVEATIIYGKKTISS-I-CS----TPKEFTD-----EV-LW-NTWLE-F-DILIRDIP QGAKLGLTINATE-----AAKET--------KSSSSKVPDHH-K-----GKLQVLYFVNL QLIDHR-S----------------LLSQGPHTLNMWPFPEWDE-E--AVTYEADKLSTAT NPDVAN---SMAIT-----FMLDRYSF---PVVLPNGRS----------SS--------- -----------------------------------------------CSGTSPV------ -----SESSSLDLAG--ESRL----SAPFSEAS----STATLTRMRN-----LKKF-KEE SV-HYVSNLPQF-LRTVNWMLPTVVQ---EVH---WLLSHW---GPEDIELFVALELLSV DFADLKVRRLAVQRL-EI-LSNDEVLKYLLQLVQTLKVEPYHDSFLARFLLKRALREQSK RIGHFFFWYLRSEVAG------C-----------------------PFFRQRMAVILEAY LLGCGEAMLAEFQSQVQVVSYLHDVALAVKLL--Y---PDRTDLP--------STGKDQT APQKLQ-ELLE--KC----DLPSDFQVPFDPRVRAGSI-I-LKDCKIMASKKKPLWLEFS CIQSEAP--PSPPV----GIIF--KHGD--DL-RQDMLIIQTLVVMDSIWQEKGLDLNLV PYGCISTGFNI---GMIEIVRNAITIASVQ--RSQGGVA-GAFKNNAL--YDWLQTKCPF QE-------------------------KHFQATEKFVN-SCAGYCVATYVLGIGDRHNDN IMITDQGNLFHIDFGHILGNTKSFWGVN--RERVPFVLTPDFLYVMGRV--KG--R-PSL YFQRFR---------------DTCINAYLSLRAQSRLLVTLFSLMLLT-GIPELSMSQDM LYLR--TA-LQQ-DQ-SEEEARNHLLQQIALCEHKGWTVQANWWFHLMAGIK-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >O_cuniculus_ENSOCUP00000010960 -------------------MELESSEQPVVLREDHGRRRRRMKPRSP---AASLSSME-- ------------------------------------------------------------ ---------------------------LIPIEFVLPT-SQRDS-KTPETALLHVAGHGNV EQMK-GQVWLRALETSVA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------ADFYHRLGPDHFLLLYQKK----GQWYEIYDKYQVVQTLDCL RYWK--LLHRSPG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QIHVVQRH----ALSEET----LAFQRQLTALIGY-------DVTDVSNVHDDEL EFTRRRLLT---PRMAEVASCD----------SRLYVMHLW--VTSKS--LLEYLA-RKI TN---NCIFIV-------------IHRSTTSQTIKVSADDTPGNILHSFFTKMAKKKSL- MDIPE-------SQSEQDFVLRVCGRDEYLVG-E-TPIRN-FQ--WV-RQC-LKNGE-EI HLVLDA--PPDP--ALD-----EVRK--EEWP---------------------------L VD----DCTGVTGYHEQ-----------------------------------------LT IHG--KDH---------------------------------------------------- ------------------------------------------------------------ ----ES----VFTVS--------LWDCDRK-FRVKVRGIDIPV-------LPRN---ADL TVFVEANIQHGQQVLCQ-R-RT----SAKPFTE-----EV-LW-NVWLE-F-SIKIKDLP KGALLNLQIYCGKA-PALSGKAS---------ADTP--GAES-R-----GKAQLLYYVNL LLIDHR-F----------------LLRHGEYVLHMWQISGKGE-D--QGSFNADKLTSAT NPDKEN---AMSIS-----ILLDNYCH---PIALPKHRP--------TPD---------- ------------------------------------------------------------ -----PEGDRVRAEM--PNQL----RKQLEAII----ATDPLNPLTAEDKELLWHF-RYE TL-KHPKAYPKL-FSSVKWGQQETVA---KTY---QLLARREVWDQSALDVGLTMQLLDC NFSDENVRAIAVQKL-ES-LEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLR--NK RIGHFLFWFLRSEIAQ------S-----------------------RHYQQRFAVILEAY LRGCGTAMLHDLTQQVLVIEMLQKVTIDIKSL--S---AEKYDVS--------SQVI--- LQLKQKLENLQ--NS----NLPTSFRVPYDPGLKAGTL-V-IEKCKVMASKKKPLWLEFK CADPTAL--SKETI----GIIF--KHGD--DL-RQDMLILQXXXXXXXXXXXXXXXXXXX XXXXXXXXXXX---XXXXXXXXXXXXXXXX--XXXXXXX-XXXXXXXX--XXXXXXXXXX XX-------------------------XFQAAVERFVY-SCAGYCVATFVLGIGDRHNDN IMISETGNLFHIDFGHILGNYKSFLGIN--KERVPFVLTPDFLFVMGTS--GK--K-TSP HFQKFQ---------------DVCVKAYLALRHHTNLLIVLFSMMLMT-GMPQLTSKEDI EYIR--DA-LTV-GK-SEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQG------ --------------------------------------------EKHSA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >T_nigroviridis_ENSTNIP00000003526 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------LDPGKYTVLYAKG----GDWYEIYDDQQAVRTLDL- -PWR--REDAGLL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SADLVVKP-VAALGWAER----KTQQECLNYLVGF-------NLDKEASDRLGEL TFTRRKLAA---PRRHQLRKRD----------HKWYSTEPW--TTSCP--LPKDLE-EQV KR---KHPITL-------------HYVDKVSFSVHVELSAKPKVLLQYFAMVMADQGLH- ------------CGADEDLVLQVFGREEFISG-D-LALSS-FL--WV-RHC-LKSDQ-DI HLSVVP--LSQL--AED-----TVTL--VDWP---------------------------L ID----DSSSHFSTHDQ-----------------------------------------LC LEG--RNL---------------------------------------------------- ------------------------------------------------------------ ----DE----IVMIS--------LWDCHRT-LRVKLLGFDVPR-------LPDR---CPQ SVSVKASILFGSKVLSS-V-CA----PPKAFAD-----EV-LW-NEWLD-F-DVPLQDLP RGSKLGFTIHETPP----VARDT--------------GAEQQ-K-----GKETLLYFVNL LLIDHR-S----------------LLSQGPHTLHMWSNPNVEE-G--AITYQADKLSTAT NPDVDE---SVAIS-----FLLDHYSF---PVVLPSSLP--------PLSD--------- -------------------------------------------------GGRP------- -----SSP-PMDPG-----------QAVHRARA----PPGSTDP--SAPRDCLRRF-REE SV-LYGTILPHY-FRNVDWMNRETVQ---DVH---WLLGNC---NPEELELTVALELLSM DFPDTMVRRLAVQRL-ES-LSNEDVLKYLLQLVQTLKVEPYHDSFLARYLIRRALS--SK RIGHFFFWYTRSEVAG------C-----------------------PYFRQRMAVVLEAY LLGCGQAMLDSFTQQVKAVEVLQEVAKTIKAL--F---PDRTDLP--------STVS--- APLRLQ-ELLR--NS----QLPPEFLLPLDPRVKAGRI-L-LDKCKVMASKKKPLWLEFS AMPSPI---ATAPV----GLIF--KEGD--DL-RQDMLVIQTLVVMDSIWQEKSLDLNLV PYGCIATGHNV---GMIEVVRKAVTIAAIQ--RSVGGTT-GAFRNNAL--YEWLRSKGPP EG-------------------------IHHTTVERFVK-SCAGYCVATYVLGIGDRHNDN IMISTHGNLFHIDFGHILGNTKHFLGMN--REHVPFVLTPDFLYVMGGA--KG--R-SSL WIQAFR---------------DTCTKAYLTLRAHSRLLITLFSLMLLT-GIPELSAAADM RYLR--KA-LQQ-EQ-SEAEAKEHFLQQIAECEKMGWTVQANWWIHMLAGIKNE------ --------------------------------------------KQHSD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >G_aculeatus_ENSGACP00000005515 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------LDPERYTLLYARG----GDWYEAYDDCQVIRTLDI- -PWS--CDHTGRR----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SAHIVVKP-LMTMNLEDK----KKQQSVLAYLIGH-------DLDTEASDRLGEL KFTRRKLAS---SRRQELRVRD----------HELYATEPW--ITSAD--IPSDLQ-GQL NR---KLPVTF-------------HYMSKISFSIEVDFSATPRVLLTFFGRVAADHGLD- ------------YDTLDRLVLKVSGREEFLSG-E-HPLSD-FL--WV-RQC-LKSNQ-DL HLSVVH--LSQL--ADE-----AVKF--VDWP---------------------------L VD----GFSGQFCSHDD-----------------------------------------LR FEG--KDV---------------------------------------------------- ------------------------------------------------------------ ----DD----IFMIS--------LWDCNRR-LRVKLLGFDIPN-------LPSK---CPQ YVYVKASILYGNKVLSS-V-SS----LPKAFEE-----EV-LW-NEWLE-F-DVLLRDLP RGAKLALTINASHGDIPPETKDS-----KSSSSSFTKAPDLH-K-----GMGNVLYFVNL LLIDHR-S----------------LLSQGPYTMHMWSYPDVEE-E--AITYEADKLSSAT NPDIAD---SMAIS-----FLLDRYSF---PVVLPNSFC--------TSER--------- -----------------------------------------------SCSSSASL----- -----PPTKSS--------------TSPNAASP----TSPPLNSLTNTNMSCLKRF-REE SI-RYGTNLPQY-LRNVDWMDRSVVE---DVH---WLLGNW---DPGELDVTVALELLSM DFSDRMVRRLAVQRL-ER-LSNDDVLMYLLQLVQTLKVEPYHDSFLARYLIQRALR--SK RIGHFFFWYVRSEVAG------G-----------------------LYFRQRMAVILEAY LLGCGQAMLDSFTQQVQAVEALQEVAITIKNF--Y---PDKTDLP--------PTAL--- APLKLR-ELLK--QS----NLPNEFLLPFDPRIKAGRI-L-LDKCKVMASKKKPLWLEFS PMPSPT---SATPV----GIIF--KEGD--DL-RQDMLVIQTLVVMDSIWQKKDLDLNLV PYGCISTGHNI---GMIEIVRNAVTIAAVH--WSQGGTS-AAFKNDAL--FEWLKSKGPL QE-------------------------IHYKTVERFVQ-SCAGYCVATYVLGIGDRHNDN IMITDQGNLFHIDFGHILGNRKHFLGMK--RERVPFVLTPDFLHVMGGG--KS--R-NSL YFQRFR-VRSSICVQVLLWFCDICTEAYLSLRSHSRMLVTLFSLMLLT-GIPELSAAEDM RYLR--EA-LQE-EQ-SEAEAKEHFLQKIDLCEHLGWTVQANWWIHMVAGIKRP------ --------------------------------------------ETHQT----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >T_rubripes_ENSTRUP00000008194 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------LDPEKYTLLYTKS----EDWYEVYDDHQVIRTLDV- -PWT--REDTGIL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SAQIVVKP--AAVESAER----KMQEQCLNYLIGY-------NLDNEASDRLDEL TFTRRKLTS---PRRQELKNRN----------DKLYTTEPW--ITSSP--VPNDCQ-DQI KR---NHPITL-------------HYMDKISFSIDVNLSACPKVLLQYFAKVMADQGLE- ------------YDTDNDLVLKVFGREEFISG-D-YALSS-FL--WL-RHC-LKTNQ-DI HLSVVS--VSQL--EEE-----TVKF--VDWP---------------------------L IE----DSSNQFSSHHN-----------------------------------------LC LE---RDH---------------------------------------------------- ------------------------------------------------------------ ----LD----IVMIS--------LWDCHRY-LRVKLLGFDIPK-------LPDK---CPQ TIYVKASVLFGSKVLSS-V-CS----SPKAFAE-----EV-LW-NEWLE-F-DVLLQDLQ RGTKLGFSINEIPP----VGKDM--------------VPEQN-K-----GKEKLLYFVNL NIIDHR-S----------------LLTQGPNTLHMWSYLNVEE-G--AITYQADKLSTAT NPDKAE---SVAIT-----FLLDSYSF---PVVLPDSLP--------LSNN--------- -------------------------------------------------SEHP------- -----SSATAQNPV-----------EAPLRNYA----PPGFLSPELNLNRDCLKRF-REE SI-LYCSVLPHY-LSTLDWMNRKIVQ---DVH---WLLGNC---NPEELDVIVALELLGI DFPDMMVRRLAVQRL-ES-LSNDDVLKYLLQLVQTLKVEPYHDSFLARYLVRRALR--SK RVGHFFFWYTRSEVTG------C-----------------------PYFRQRMAVILEAY LLGCGQAMLDSFIQQVKAVEVLHKVAKTTKSL--F---PDKTDLP--------ISIV--- ILLLLKLEHVSNINS----QLPHEFLLPFDPRVKAGRI-L-LDKCKVMASKKKPLWLEFC PMPSPI---TAAPV----GIIF--KEGD--DL-RQDMLVIQTLMVMDSIWQERSLDLNLV PYGCISTGHNI---GMIEIVRNAVTIAAIQ--RSVGGTT-GAFRNDAL--YEWLRSKGPP EE-------------------------IHHTTVERFVK-SCAGYCVATYVLGIGDRHNDN IMVTNDGNLFHIDFGHILGNTKHFLGMN--REHVPFVLTPDFLYVMGGA--KG--R-SSL WIQAFRKLRITYIFTLSYSFQDTCTRAYLSLRSHSQLLITLFSLMLLT-GIPELSTSEDM RYLR--KA-LQE-EQ-SETEAKEHFLQQIAECEKMGWTVQANWWIHMLAGIK-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >O_anatinus_ENSOANP00000005029 -------------------MDPEAPEPPVLLREAAKRRRRRMKAYGTPGPPVPPAPSE-- ------------------------------------------------------------ ---------------------------LIPIEFTLPA-RRRDSPETPETVTLDVPGNGSV EQMK-AQLWAHAAELGPV------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GAFFQRSCPDQFLLLYQKR----GQWYEVYDRHQAVQTLDCV LHWK--VTRLPVG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----HIRVAPRP----QPTPEV----LDFQRRLTELIGY-------DVTDVSNVHDDEL ESTRRRLLA---PRAAEVAGRD----------PGLYAMHPW--VTSKP--LPAYLQ-GKV AN---GHVLLV-------------IHRGTTSQTVKVSVDETPGAILRGFFTRMAKKKSL- MGIPE-------GLGERDFVLRVCGRDEYLVG-E-TPVKN-FQ--WV-RQC-LKNGE-DI HLVLDA--PPDP--ALD-----RVRE--EEWP---------------------------L VD----DGPGATGYHDQ-----------------------------------------LT VAG--KSH---------------------------------------------------- ------------------------------------------------------------ ----ER----VLTVS--------LWDCDRR-FRVKIRGF-------------------EP TVFVEAKVQHGQQLLSQ-S-RT----TSKPWAE-----EV-LW-NQWLE-F-GIRIKDLP RGALLNLQIY-----------------------------------------HQLLYYVNL LLVDHR-S----------------LLRRGGYVLHMWKTSGKED-G--RGSLNADKLTSAT NPDKEN---SVAIS-----VLLDDYCH---PVALPK------------------------ ------------------------------------------------------------ -------------QM--PNQL----RKQLEEIV----ATDPLHPLSAEDKELLWHF-RHE SL-KHPEAYPKL-FSAVDWGRQETVA---VAY---RLLARREVWDRSALDVGLTLQLLDC NFSDENVRAMAVQKL-ES-LEDDDVLHFLLQLVQAVKFEPYHDSALARFLLKRGLR--NK RIGHFLFWFLRSEIAQ------S-----------------------PHYQQRFAVLLEAY LRGCGQAMLQDFTRQVQVTRLLHKLTLEIKSL--S---ADKYDVT--------PQVV--- AQLKEKLENLQ--NS----HLPDSFRVPYDPGLKAGKL-V-IEKCKVMASKKKPLWLEFQ CADPTAL--SSETI----GVIF--KHGD--DL-RQDMLILQILRIMESIWETESLDLCLL PYGCISTGDKI---GKPPLGASENSLRLLG--EWT-GEP-WAWNIETLGHHRWWGEGCGH RE-----------------------------SINRITHISQEGWTPSIQVL-----NPDS SLLL--GNLFHIDFGHILGNYKSFLGIS--KERVPFVLTPDFLFVMGTA--GK--K-TSK HFQKFQ--------EGEADTGEVCVRAYLALRHHTNLLIILFSMMLMT-GMPQLTSKEDI AYIR--DA-LTV-GK-SEEEAEKYFLDQIEVCRDKGWTVQCNWFLHLVLGIKQG------ --------------------------------------------EKHST----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >O_latipes_ENSORLP00000002186 ------------------------VNLPNFSNEHVIRNLLKNKKSSPRPLAGSMPIEK-- ------------------------------------------------------------ ---------------------------KIALIFLLNRLIEWSTTLISGMVHWRAPCR-ET RETK-ASVLKKTLAFSIF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------TAFLHVFDPKKYALLYARD----DDLYEAYDDCQVLRTLDI- -PWS--KEDSCCL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SAYILVKPMVVVVDTEEM----KRQQQSLTYLVGH-------DLEEDATDRLDEL TFTRRKLAS---LRRQELRNRD----------DVQYTTDPW--VTSAP--ITDELQ-EWL NR---RLPVTF-------------HYMSKISFSVEVDINATPEVLLQVFVKVIEDQGLE- ------------CDTSKDLVLKVTGREEYFTG-N-HTLIN-FL--WV-RRC-LITNQ-EL HLSVLP--VSHV--VPE-----TVQF--VDWP---------------------------L VD----GFSGKFSSHND-----------------------------------------LT LQE--KDL---------------------------------------------------- ------------------------------------------------------------ ----DD----IFMIS--------LWDCNRK-FRVKLLGFDIPE-------MPNK---SQQ MVYVEASLLYGNKSMFS-V-SS----SAKLLAD-----EV-LW-NEWLD-F-DVLLSDLP RGVKLSLTINAKDSDTTSAAKEQ-------KQSSTNKASESL-K-----IKGNVLFFVSL LLIDHR-S----------------VLSQGPFTLHMWPYLHKEH-D------QADRLSSAT NPDKAN---SMAIS-----ILLDRYRF---PVVLPNAFS--------DNAP--------- -----------------------------------------------SSSASLFL----- -----PSSSNTDPLS--PDES----IPQFTDSP-------TLRSPTSVASCRRRSF-KMG SV-QYSSSFPQF-LRKVEWMNRKAVE---DVH---WLLSTLILHVRPAKEKNSNIYINDS QFNSFMFGPIKVLKF-CI-QQDSFIVGQRCCLRQTLKVEPFHDSFLARYLIQRALR--SK RIGHFFFWFVRSEVVS------G-----------------------QYFRERMAVILEAY LLGCGAAMINSFIQQVQAVEALQEVAIRIKNL--Y---PDKTNLD--------STRLIS- APLKLQ-ELLR--NS----NLPNEFVLPFDPRVKAGKI-L-LENCKVMASKKKPLWLEFS PMPSPI---SSSPV----GIIF--KEGD--DL-RQDMLVIQTLVIMDSIWQEKSLDLNLI PYGCIATGHNI---GMIEIVRNAVTLAAIQ--KSFGGSA-GAFKNNAL--FEWLKSKCPL QE-------------------------IHYKTVERFVK-SCAGYCVAMYVLGIGDRHNDN IMITDQGNLFHIDFGHILGNRKQFLGMK--RERVPFVLTPDFLYVMGRV--KS--H-NSL YFQKFV---TDMTVSVVTIFEDTCIQAYLLLRPHSQLLVTLFSLMLLT-GIPELSTSEDM RYLK--EV-LQQ-EQ-TDAEAKEHFLQQISECQKQGWTVQTNWWIHMVAGISFL------ --------------------------------------------EAHTA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >M_domestica_ENSMODP00000034801 ----------MAQLSSNNGFKQCSSSPSGPAKTKD-VDREEALQMEAEALAKLQKDNKRV V-----------------------------------------ENQPGF---EFSSSIAQK SQEINS------------------KQDLDLMVFPESDSPKRA-----VDIDIEKLTHAEL EKLLLDDNFESSKAPTVPGTPVLSPSFSAQFYLRP-----------TIQRGQWSPGFPGP ------------C--TL-------PSIYPS-PYCKQAGAFQNGFSSSMSTFPSAEPIYLS FPR-Q---SQYISYPSTPSTSFHP-QGSL------------------------------- ------------------PIYRPAVSPEMAKLFDKIA-----STSEFLKNGKARTDLEIN NTKATVSNLQGSP--------KSDDIS--------------------------------- ---------------KFDWLDLDPLSKPK-VDNVEVLDHGE--------------EKNTP ILTAED-------------------PWDAVLLEKRSST---GCNPEKKVNG--------- KPLLGSTVTRSHSLNIRSAQLT-------------------------------------- -----KAQ-----------GQVHQ---KE-SGTSSLSSGS-------SLLQEDEIQNEEV AAFCKTVSK---LRTNFPHTSRLT---NPGYVLSPVMMQRN-TCGENS-SVKVSI----- -----------------------EIEGFQLPVTFTCDVSSTVEIIIMQALCWVHDDLNQ- ------------VD-VGSYVLKVCGQEEVLQK-N-PYLPSKEE--ES-KNK-RKKET-KL RLNILK---RFF--TIH-----LVLAAEDDKTPTDLSKYLHHIENPFKEVMT-RHSVEEL LDTYHNQVEMAFLNE-N-------------------QHRAVDQVIKAVRKICSALDG-VE TLAITESV--KKLKRAVNLPRSKSAEV-------------SRSPV-NVLQVYFNL-GSL- -------------------TSENPVQVSIDQLTAAIYDLLRLHS-SSY-GGSID------ -YGQSH----RTTKE--------AWTTTEQ-LQFTIFAAHG---------ISSSWVANYE KYYLICSLTHNGKDLFK-PIHS----KKVGTYK-NFFYLI-KW-DELII-F-PIQISQLP LESLLHLTLYGILN----QNSGS-----------SPDSNKQR-------KGPEILGKVSL PLFDFK-R----------------FLTCGTKLLYLWTSSPT-Q------PIPGITHKKGQ VMER------IVLQ-----VDFPSPSF---DIIYTTPQV--------NGSI--------- ------------------------------------------------------------ -----VQPQCLETL---EKDT----KGKLLAIL----SRDSSFGLSKEDKAFLWEK-RYY C-LTHPNCLPKI-LASAPNWKWANLS---KTY---SLLQQW-----PPLPPLNALELLDS KFADQEVRALAVNWI-ET-ISDDELADFLPQFVQALKYEIYLDNSLVRFLLSRALG--NI RIAHYLYWLLKDAL-H------D-----------------------AQFGVRYEHILGAF LSTGGRGLREELLKQTKLVQLLGGVAEKVRQA--S---GSARQ----------------- VVLQRSMERVQS-FF----LRN-KCRLPLNPSLVAKEL-N-IKTCSFFSSNAVPLKVTMV NADPL-----GEEI----NVMF--KVGE--DL-RQDMLALQMIKIMDKIWLKEGLDLRMV IFKCLSTGKDR---GMVELVPASDTLRKIQV---EYGVT-GSFKDKPL--AEWLRKYNPS EE-------------------------EYEKASENFIY-SCAGCCVATYVLGICDRHNDN IMLRSTGHMFHIDFGKFLGHAQMFGSFK--RDRAPFVLTSDMAYVINGG--EK----PTI RFQLFV---------------DLCCQAYNLIRKQTNLFLNLLSLMIPS-GLPELTSIQDL KYVR--DA-LQP-QT-TDAEATIFFTRLIESSL-GSIATKFNFFIHNLAQLRFSGLPSND EPILSFSPKTYSFKQDGRIKEVSVFTYHKKYNPDKHYVYVVRILREGQI-EPSFVFRTFD EFQELHNKLSILFPLWKLPGYPGLMVLGRTHIKDVAAKRKIELNSYLQSLMTASIDVAEC D-----------LVCTFFHPLLRDEKAEGI-------AR--SADANPLS-PTSGQVGGAV KLSISYRNGTLFIMVMHIKDLV-TEDGADPNPYVKTYLLPDTHKTSKRKTKISRKTRNPT FNEM--LIYSGYSKETLRQRELQLSVLSAESLRENF-FLGGITLPLKDFNLSNETVKWYQ LTATLY--L >E_caballus_ENSECAP00000013077 ----------MAQISSNNGFKQCSSSHLELTRTKD-VDKAEALQMEAEALAKLQKD-RRV T-----------------------------------------DNQRGF---ELSSSTRQK AQ-VYN------------------KQDYDLMVFPESDTQKRA-----VDIDVEKLTQAEL EKLLLDDSFETRTAPVLPVTPVLSPSFSAQLYLRP-----------TIQRGQWPPGLSGP ------------STYTL-------PSIYQS-TYSSKQTSFQNGFNPRMPTFPSTEPIYLS LPG-Q---SPYFSYPLTPATHFHP-QASL------------------------------- ------------------PICRPLVSPDMAKLFDKIA-----STSEFLKNGKARTDLEIT NSKATISNLQVSP--------KSEDIS--------------------------------- ---------------KFDWLDLDPLSKPK-VDSVEVLDHEE--------------EKNAP GLLAED-------------------PWDAVLLEERSLA---SCHLERKVNG--------- KSLSGATVTRSQSLNIRTTQLT-------------------------------------- -----KVQ-----------GQMSQ---KDSNGTSSLPTGS-------SLLQEIEVQNEEV AAFCQSITT---LKINFPYTNHYT---NPGYLLSPVTVQRN-ICGENA-SVKISI----- -----------------------EIEGFQLPVTFTCDVSSTVEIVIMQALCWVHDDLNQ- ------------VD-VGSYVLKVCGQEEVLQN-N-HCLGS-HE--HI-QNC-RKWDT-EI KLQLLT--FSSM--CQN-----LARTAEDDETPVDLNKYLHQIEKPYKEVMT-RHPVEEL LDSYHNQVELALQIE-N-------------------QHRAVDQVIKAVRKICSALDG-VE TLAITESV--KKLKRAVNLPRSKSANM-------------TSLSGREDTSKSSTR-GSL- -------------------NSENPVQVSMDQLTAAIYDLLRLHA-STG-GSPAD------ -CTQSN----RNIKE--------AWTTTEQ-LQFTIFAAHG---------ISSNWVSNYE KYYLICSLSYNGKDLFK-PIQS----KKVGTYK-NFFYLI-KW-DELII-F-PIQISQLP LECLLHLTLFGILN----QSSGS-----------SPDSNKQR-------KGPEALGKVSL PLFDFK-R----------------FLTCGTKLLYLWASSHT-N------PVPGTVPKKGY VMER------IVLQ-----VDFPSPTF---DIVYTTPQV--------DRSI--------- ------------------------------------------------------------ -----IQQHNLETL---ENDI----KGKLLDIL----HRDSSLGLSKEDKAFLWEK-RYY C-FKHPNCLPKV-LASAPNWKRVNLA---KTY---SLLQEW-----PPLHPLTALELLDS KFADQEVRSLAVTWI-EA-ISDDELTDLLPQFVQALKYEIYLNSSLVRFLLSRALG--NI QIAHNLYWLLRDAL-H------D-----------------------AQFGARYEHVLGAL LSVGGKGLREELLKQTKLVQLLGGVAEKVRQA--S---GSARQ----------------- VVLQRSMERVQS-FF----LKN-KCRLPLNPSLVAKEL-N-IKSCSFFSSNAVPLKVTMV NADPM-----GEEI----NVMF--KVGE--DL-RQDMLALQMIKIMDKIWLKEGLDLRMV IFKCLSTGRDR---GMVELVPASDTLRKIQV---EYGVT-GSFKDKPL--AEWLRKYNPS EE-------------------------EYEKASENFIY-SCAGCCVATYVLGICDRHNDN IMLRSTGHMFHIDFGKFLGHAQMFGSFK--RDRAPFVLTSDMAYVINGG--EK----PTI RFQLFV---------------DLCCQAYNLIRKQTNLFLNLLSLMIPS-GLPELTSIQDL KYVR--DA-LQP-QT-TDAEATIFFTRLIESSL-GSIATKFNFFIHNLAQLRFSGLPSND EPILSFSPKTYSFRQDGRIKEVSVFTYHKKYNPDKHYIYVVRILREGQL-EPSFVFRTFD EFQELHNKLSIIFPLWKLPGFPNRMVLGRTHIKDVAAKRKIELNSYLQSLMSASTDVAEC D-----------LVCTFFHPLLRDEKAEGI-------AR--SADAGLFS-PTPGQIGGAV KLSVSYRNGTLFIMVMHIKDLV-TEDGADPNPYVKTYLLPDTHKTSKRKTKISRKTRNPT FNEM--LVYSGYSKETLRQRELQLSVLSAESLRENF-FLGGVTLPLKDFNLSKETVKWYQ LTAATY--L >M_musculus_ENSMUSP00000081710 ----------MAQISNNSEFKQCSSSHPEPIRTKD-VNKAEALQMEAEALAKLQKD-RQM T-----------------------------------------DSPRGF---ELSSSTRQR TQ-GFN------------------KQDYDLMVFPELDSQKRA-----VDIDVEKLTQAEL EKILLDDNFETRKPPALPVTPVLSPSFSTQLYLRP-----------SGQRGQWPPGLCGP ------------STYTL-------PSTYPS-AY-SKQATFQNGFSPRMPTFPSTESVYLR LPG-Q---SPYFSYPLTPATPFHP-QGSL------------------------------- ------------------PVYRPLVSPDMAKLFEKIA-----STSEFLKNGKARTDLEIA NSKASVCNLQISP--------KSEDIN--------------------------------- ---------------KFDWLDL-------------------------------------- -----D-------------------PWDAVLLEERSP----SCHLERKVNG--------- KSLSGATVTRSQSLIIRTAQFT-------------------------------------- -----KAQ-----------GQVSQ---KDPNGTSSLPTGS-------SLLQEFEVQNDEV AAFCQSIMK---LKTKFPYTDHCT---NPGYLLSPVTVQRN-MCGENA-SVKVSI----- -----------------------EIEGLQLPVTFTCDVSSTVEIIIMQALCWVHDDLNQ- ------------VD-VGSYILKVCGQEEVLQN-N-HCLGS-HE--HI-QNC-RKWDT-EI KLQLLT--LSAM--CQN-----LARTAEDDEAPVDLNKYLYQIEKPYKEVMT-RHPVEEL LDSYHYQVELALQTE-N-------------------QHRAVDQVIKAVRKICSALDG-VE TPSVTEAV--KKLKRAVNLPRNKSADV-------------TSLSG-SDTRKNSTK-GSL- -------------------NPENPVQVSMDHLTTAIYDLLRLHA-NSS-RCSTG------ -CPRGS----RNIKE--------AWTATEQ-LQFTVYAAHG---------ISSNWVSNYE KYYLICSLSHNGKDLFK-PIQS----KKVGTYK-NFFYLI-KW-DELII-F-PIQISQLP LESVLHLTLFGVLN----QSSGS-----------SPDSNKQR-------KGPEALGKVSL TLFDFK-R----------------FLTCGTKLLYLWTSSHT-N------SIPGAIPKKSY VMER------IVLQ-----VDFPSPAF---DIIYTSPQI--------DRNI--------- ------------------------------------------------------------ -----IQQDKLETL---ESDI----KGKLLDII----HRDSSFGLSKEDKVFLWEN-RYY C-LKHPNCLPKI-LASAPNWKWANLA---KTY---SLLHQW-----PPLCPLAALELLDA KFADQEVRSLAVSWM-EA-ISDDELADLLPQFVQALKYEIYLNSSLVRFLLSRALG--NI QIAHSLYWLLKDAL-H------D-----------------------THFGSRYEHVLGAL LSVGGKGLREELSKQMKLVQLLGGVAEKVRQA--S---GSTRQ----------------- VVLQKSMERVQS-FF----LRN-KCRLPLKPSLVAKEL-N-IKSCSFFSSNAMPLKVTMV NADPL-----GEEI----NVMF--KVGE--DL-RQDMLALQMIKIMDKIWLKEGLDLRMV IFRCLSTGRDR---GMVELVPASDTLRKIQV---EYGVT-GSFKDKPL--AEWLRKYNPS EE-------------------------EYEKASENFIY-SCAGCCVATYVLGICDRHNDN IMLRSTGHMFHIDFGKFLGHAQMFGSFK--RDRAPFVLTSDMAYVINGG--EK----PTI RFQLFV---------------DLCCQAYNLIRKQTNLFLNLLSLMIPS-GLPELTSIQDL KYVR--DA-LQP-QT-TDAEATIFFTRLIESSL-GSIATKFNFFIHNLAQLRFSGLPSND EPILSFSPKTYSFRQDGRIKEVSVFTYHKKYNPDKHYIYVVRILREGHL-EPSFVFRTFD EFQELHNKLSIIFPLWKLPGFPNRMVLGRTHIKDVAAKRKIELNSYLQSLMNASTDVAEC D-----------LVCTFFHPLLRDEKAEGI-------AR--SAGAVPFS-PTLGQIGGAV KLSVSYRNGTLFIMVMHIKDLV-TEDGADPNPYVKTYLLPDTHKTSKRKTKISRKTRNPT FNEM--LVYSGYSKETLRQRELQLSVLSAESLRENF-FLGGITLPLKDFNLSKETVKWYQ LTAATY--L >O_anatinus_ENSOANP00000012246 ----------MAQISNSNGLKQHSSSPLGLTRTKD-VDKAEALQMEAEALAKLQKD-KRV V-----------------------------------------DNQRGL---GLLGNTRQK AQ-VQS------------------QEEHDLMVFPESETKKGA-----ADIDIEKLSHAEL EKLLLDDSFESSKASAFPVTPVLSPSFSAQFCLQP-----------TIQRAQWPPGFPGP ------------SPCTL-------PSIYPP-AFSKRAGAFQNGLSPSLSTFQSTDPIYLS LPG-Q---SPYISYPLTATTPFLP-QGSL------------------------------- ------------------PVYRPAVSPEMAKLFDKIA-----STKEFLKNGKASTDLEIS SSKAPVSSLQMPP--------KTSDIS--------------------------------- ---------------KFDWLDLDPLSKPK-VDSVEALDDEE-------------KEKITP VVTAKD-------------------PWDAVLLEERSPA---SCHPERRVNG--------- KSCFGATVTRSQSLNIRSTQLT-------------------------------------- -----KVQ-----------GQTAQ---KD-CGTSSLPSGS-------SFLQEIEIQNEEV AAFCQAITK---LRTNFPYSNRHT---NPGYVLSPVMLQRN-ICGENS-SVKVSI----- -----------------------EIEGFQLPVTFTCDVSSTVEIVIMQALCWVHDDLNQ- ------------VD-TGSYVLKVCGQEEVLQN-K-HCLGS-HE--YI-QIC-RKWDT-EI KLQLLT--FRAM--CQD-----LARTAEDDKAPISLTKHLLYIEKPFKEIMT-RHSVEEL LDTYHSQVELALKNE-N-------------------QHRGVDQVIKAVRKICSALDG-VE TLAVTESV--KRLKRAVNLPRSKSAEV-------------TSKSG-SSASRSSTG-GSL- -------------------CPDNPVQVSINQLTAAIYDLLKLHASSSG-ISLAD------ -AAESG----RSTKE--------AWTTSEQ-LQFTVYAAHG---------IFTGWVANYE KYYLICSLTHNGKDLFK-PIHS----KKVGTYK-NFFYLI-KW-DELII-F-PIQISQLP LESVLHLTLYGILS----QNSGS-----------SPDSNKQR-------KGPEMLGKVSL PLFDFK-R----------------VLTCGTKLLHLWTSAQT-Y------PPPGIVHKKGH LMER------IVLQ-----VDFPSSDF---DILYTTPQA--------GSCS--------- ------------------------------------------------------------ -----VQQQCLEIL---EKDA----KGKLLAIL----CKDSPIGLSKEDKAFLWEK-RHY C-LKHSNSLPKI-LASAPNWKWENLS---KTY---SLLQQW-----PPLPPLTALELLDS KFADQEVRTIAVNWI-EA-ISDDELADFLPQFVQALKYEIYLDSALVRFLLARALG--NI RIAHYLYWLLKDAL-H------D-----------------------AQFGVRYEHILGAF LSVGGRGLREELAKQTRLVQLLGVVAEKVRQA--S---GSARQ----------------- VVLQGGMERVQS-FF----LRN-RCRLPLNPSLVAKEL-N-IKTCSFFSSNAVPLKVTMV NADPM-----GEEI----NVMFKPKVGE--DL-RQDMLALQMIKIMDKIWLKEGLDLRMV IFKCLSTGKDR---GMVELVPTSDTLRKIQV---EYGVT-GSFKDKPL--AEWLRKYNPS EE-------------------------EYEKASENFIY-SCAGCCVATYVLGICDRHNDN IMLRSTGHMFHIDFGKFLGHAQMFGSFK--RDRAPFVLTSDMAYVINGG--EK----PTI RFQLFV---------------DLCCQAYNLIRKQTSLFLNLLSLMIPS-GLPELTSIQDL KYVR--DA-LQP-QN-TDAEATIFFTRLIESSL-GSVATKFNFFIHNLAQLRFSGLPSND EPILSFSPKAYSFKQDGRIREASVFTYHKKYNPDKHYIYVVRVLREGQL-EPTFVFRTFD EFQELHNKLGILFPLWKLPGFPNRMVLGRTHIKDVAAKRKIELNSYLQSLMNASPEVAEC D-----------LVCTFFHPLLRDEKAEGI-------AR--SADASPSS-PTSGQVGGAV KLSVSYRNGTLFIMVMHIKDLV-TEDGADPNPYVKTYLLPDIHKTSKRKTKISRKTRNPT FNEM--LVYSGYSKEVLKQRELQLSVLSAESLRENF-FLGGVTLHLKDFNLSKETVRWYQ LTAVPY--V >R_norvegicus_ENSRNOP00000051993 ----------MAQISNNSEFKQCSSSHPEPIRTKD-VDKAEALQMEAEALAKLQKD-RHM T-----------------------------------------DSPRGF---ELSNSTRQR TQ-GFN------------------KQDYDLMVFPESDSQKRA-----LDIDVEKLTQAEL EKILLDDNFETRKTPASPVTPVLSPSFSAQLYLRP-----------AVQRSQWPPGLCGP ------------STYTL-------PSIYPS-AY-SKQATFQNGFSPRMPTFPSTESIYLR LPG-Q---SPYFSYPLTPATPFHP-QGSL------------------------------- ------------------PVYRPLVSPDMAKLFDKIA-----STSEFLKNGKARTDLEIA NSKASVCNLQISP--------KSEDIN--------------------------------- ---------------KFDWLDLDPLSKPK-IDCVEVLEHEE--------------EKKNP VLLAED-------------------PWDAVLLEERSPT---SRHLERKVNG--------- KSLSGATVTRSQSLIVRTTQVT-------------------------------------- -----KAQ-----------SQVSQ---KDPNGTSSLATGS-------SLLQEFEVQNEEV AAFCQSIMK---LKTKFPYTDHCT---NPGYLLSPVTVQRN-MCGENA-SVKVSI----- -----------------------EIEGFQQPVTFTCDVSSTVDIIIMQALCWVHDDLNQ- ------------VD-VGSYILKVCGQEEVLQN-N-HCLGS-HE--HI-QNC-RKWDT-EI KLQLLT--FSAM--CQN-----LARTAEDDEAPVDLNKYLYQIEKPYKEVMT-RHPVEEL LDSYHYQVELALQTE-N-------------------QHRAIDQVIKAVRKICSALDG-VE TPAVTEAV--KKLKRAVNLPRNKSADV-------------TSLSG-GDTSKNSTR-GSL- -------------------NLENPVQVSMDHLTAAIYDLLRLHT-NSC-KSSTV------ -CPQGS----RNIKE--------AWTATEQ-LQFTVYAAHG---------ISSNWVSNYE KYYLICSLSHNGKDLFK-PIQS----KKVGTYK-NFFYLI-KW-DELII-F-PIQISQLP LESVLHLTLFGVLN----QSSGS-----------SPDSNKQR-------KGPEALGKVSL TLFDFK-R----------------FLTCGTKLLYLWTSSHT-N------SIPGAIPQKSY VMER------IVLQ-----VDFPSPAF---DIIYTSPQI--------DRNI--------- ------------------------------------------------------------ -----IQQYKLEAL---ENEI----KGKLLDIV----HRDSSFGLSKEDKAFLWEK-RYY C-LKHPNCLPKI-LASAPNWKWANLA---KTY---SLLHQW-----PPLCPLAALELLDA KFADQEVRSLAVSWI-EA-ISDDELTDLLPQFVQALKYEIYLNSSLVRFLLSRALG--NI QIAHSLYWLLKDAL-H------D-----------------------TRFGSRYEHVLGAL LSVGGKGLREELSKQMKLVQLLGGVAEKVRQA--S---GSARQ----------------- VVLQKSMERVQS-FF----LRN-KCRVPLKPSLVAKEL-N-IKSCSFFSSNAMPLKVTMV NADPL-----GEEI----NVMF--KVGE--DL-RQDMLALQMIKIMDKIWLKEGLDLRMV IFKCLSTGRDQ---GMVELVPASDTLRKIQV---EYGVT-GSFKDKPL--AEWLRKYNPS EE-------------------------EYEKASENFIY-SCAGCCVATYVLGICDRHNDN IMLRSTGHMFHIDFGKFLGHAQMFGSFK--RDRAPFVLTSDMAYVINGG--EK----PTI RFQLFV---------------DLCCQAYNLIRKQTNLFLNLLSLMIPS-GLPELTSIQDL KYVR--DA-LQP-QT-TDAEATIFFTRLIESSL-GSIATKFNFFIHNLAQLRFSGLPSND EPILSFSPKTYSFRQDGRIKEVSVFTYHKKYNPDKHYIYVVRILREGHL-EPSFVFRTFD EFQELHNKLSIIFPLWKLPGFPNRMVLGRTHIKDVAAKRKIELNSYLQSLMNASTDVAEC D-----------LVCTFFHPLLRDEKAEGI-------AR--STGTSPFS-PTLGQIGGAV KLSVSYRNGTLFIMVMHIKDLV-TEDGADPNPYVKTYLLPDTHKTSKRKTKISRKTRNPT FNEM--LVYSGYSRETLRQRELQLSVLSAESLRENF-FLGGITLPLKDFNLSKETVKWYQ LTAATY--L >P_pygmaeus_ENSPPYP00000003968 ----------MAQISSNSGFKECPSSHPEPTRAKD-VDKEEALQMEAEALAKLQKD-RQV T-----------------------------------------DNQRGF---ELSSSTRKK AQ-VYN------------------KQDYDLMVFPESDSQKRA-----LDIDVEKLTQAEL EKLLLDDSFETRKTPVLPVTPILSPSFSAQLYFRP-----------TIQRGQWPPGLSGP ------------STYAL-------PSIYPS-TY-SKQAAFQNGFNPRMPTFPSTEPIYLS LPG-Q---SPYFSYPLTPATPFHP-QGSL------------------------------- ------------------PIYRPVVSPDMAKLFDKIA-----STSEFLKNGKARTDLEIT DSK--VSNLQVSP--------KSEDIS--------------------------------- ---------------KFDWLDLDPLSKPK-VDNVEVLDHEE--------------EKNVS SLLAKD-------------------PWDAVLLEERSTA---NCHLERKMNG--------- KSLSVATVTRSQSLNIRTTQLA-------------------------------------- -----KA-------------HISQ---KDPNGTSSLPTGS-------SLLQEVEVQNEEM AAFSRSITK---LKTKFPYTNHHT---NPGYLLSPVTAQRN-ICGENA-SVKVSI----- -----------------------DIEGFQLPVTFTCDVSSTVEIIIMQALCWVHDDLNQ- ------------VD-VGSYV-KVCGQEEVLQN-N-HCLGS-HE--HI-QNC-RKWDT-EI RLQLLT--FSAM--CQN-----LARTAEDDETPVDLNKHLYQIEKPYKEAMT-RHPVEEL LDSYHNQVELALQIE-N-------------------QHRAVDQVIKAVRKICSALDG-VE TLAITESV--KKLKRAVNLPRSKTADV-------------ASLFGGEDTSKSSTR-GSL- -------------------NPENPVQVSINQLTAAIYDLLRLHA-NSG-RSPTD------ -CAQSS----KSVKE--------AWTTTEQ-LQFTIFAAHG---------ISSNWVSNYE KYYLICSLSHNGKDLFK-PIQS----KKVGTYK-NFFYLI-KW-DELII-F-PIQISQLP LESLLHLTLFGILN----QSSGS-----------SPDSNKQR-------KGPEALGKVSL PLFDFK-R----------------FLTCGTKLLYLWTSSHT-N------SVPGAVTKKGY VMER------IVLQ-----VDFPSPAF---DIIYTTPQV--------DRSI--------- ------------------------------------------------------------ -----IQQHNLETL---ENDV----KGKLLDIL----HKDSSLGLSKEDKAFLWEK-RYY C-FKHPNCLPKI-LASAPNWKWVNLA---KTY---SLLHQW-----PALYPLIALELLDS KFADQEVRSLAVTWI-EA-ISDDELTDLLPQFVQALKYEIYLNSSLVQFLLSRALG--NI QIAHNLYWLLKDAL-H------D-----------------------VQFSTRYEHVLGAL LSVGGKRLREELRKQTKLVQLLGGVAEKVRQA--S---GSARQ----------------- VVLQRSMERVQS-FF----QKN-KCRLPLKPSLVAKEL-N-IKSCSFFSSNAVPLKVTMV NADPM-----GEEI----NVMF--KVGE--DL-RQDMLALQMIKIMDKIWLKEGLDLRMV IFKCLSTGRDR---GMVELVPASDTLRKIQV---EYGVT-GSFKDKPL--AEWLRKYNPS EE-------------------------EYEKASENFIY-SCAGCCVATYVLGICDRHNDN IMLRSTGHMFHIDFGKFLGHAQMFGTFK--RDRAPFVLTSDMAYVINGG--EK----PTI RFQLFV---------------DLCCQAYNLIRKQTNLFLNLLSLMIPS-GLPELTSIQDL KYVR--DA-LQP-QT-TDAEATIFFTRLIESSL-GSIATKFNFFIHNLAQLRFSGLPSND EPILSFSPKTYSFKQDGRIKEVSVFTYHKKYNPDKHYIYVVRILREGQI-EPSFVFRTFD EFQELHNKLSIIFPLWKLPGFPNRMVLGRTHIKDVAAKRKIELNSYLQSLMNASTDVAEC D-----------LVCTFFHPLLRDEKAEGI-------AR--SADAGSFSPPTPGQIGGAV KLSISYRNGTLFIMVMHIKDLV-TEDGADPNPYVKTYLLPDNHKTSKRKTKISRKTRNPT FNEM--LVYSGYSKETLRQRELQLSVLSAESLRENF-FLGGVTLPLKDFNLSKETVKWYQ LTAATY--L >P_troglodytes_ENSPTRP00000005931 ----------MAQISSNSGFKECPSSHPEPTRAKD-VDKEEALQMEAEALAKLQKD-RQV T-----------------------------------------DNQRGF---ELSSSTRKK AQ-VYN------------------KQDYDLMVFPESDSQKRA-----LDIDVEKLTQAEL EKLLLDDSFETKKTPVLPVTPILSPSFSAQLYFRP-----------TIQRGQWPPGLSGP ------------STYAL-------PSIYPS-TY-SKQAAFQNGFNPRMPTFPSTEPIYLS LPG-Q---SPYFSYPLTPATPFHP-QGSL------------------------------- ------------------PIYRPVVSTDMAKLFDKIA-----STSEFLKNGKARTDLEIT DSK--VSNLQVSP--------KSEDIS--------------------------------- ---------------KFDWLDLDPLSKPK-VDNVEVLDHEE--------------EKNVS SLLAKD-------------------PWDAVLLEERSTA---NCHLERKVNG--------- KSLSVATVTRSQSLNIRTTQLA-------------------------------------- -----KAQ-----------GHISQ---KDPNGTSSLPTGS-------SLLQEVEVQNEEM AAFCRSITK---LKTKFPYTNHRT---NPGYLLSPVTAQRN-ICGENA-SVKVSI----- -----------------------DIEGFQLPVTFTCDVSSTVEIIIMQALCWVHDDLNQ- ------------VD-VGSYVLKVCGQEEVLQN-N-HCLGS-HE--HI-QNC-RKWDT-EI RLQLLT--FSAM--CQN-----LARTAEDDETPVDLNKHLYQIEKPYKEAMT-RHPVEEL LDCYHNQVELALQIE-N-------------------QHRAVDQVIKAVRKICSALDG-VE TLAITESV--KKLKRAVNLPRSKTADV-------------TSLFGGEDTSKSSTR-GSL- -------------------NPENPVQVSINQLTAAIYDLLRLHA-NSG-RSPTD------ -CAQSS----KSVKE--------AWTTTEQ-LQFTIFAAHG---------ISSNWVSNYE KYYLICSLSHNGKDLFK-PIQS----KKVGTYK-NFFYLI-KW-DELII-F-PIQISQLP LESVLHLTLFGILN----QSSGS-----------SPDSNKQR-------KGPEALGKVSL PLFDFK-R----------------FLTCGTKLLYLWTSSHT-N------SVPGTVTKKGY VMER------IVLQ-----VDFPSPAF---DIIYTTPQV--------DRSI--------- ------------------------------------------------------------ -----IQQHNLETL---ENDI----KGKLLDIL----HKDSSLGLSKEDKAFLWEK-RYY C-FKHPNCLPKI-LASAPNWKWVNLA---KTY---SLLHQW-----PALYPLIALELLDS KFADQEVRSLAVTWI-EA-ISDDELTDLLPQFVQALKYEIYLNSSLVQFLLSRALG--NI QIAHNLYWLLKDAL-H------D-----------------------VQFSTRYEHVLGAL LSVGGKRLREELLKQTKLVQLLGGVAEKVRQA--S---GSARQ----------------- VVLQRSMERVQS-FF----QKN-KCRLPLKPSLVAKEL-N-IKSCSFFSSNAVPLKVTMV NADPM-----GEEI----NVMF--KVGE--DL-RQDMLALQMIKIMDKIWLKEGLDLRMV IFKCLSTGRDR---GMVELVPASDTLRKIQV---EYGVT-GSFKDKPL--AEWLRKYNPS EE-------------------------EYEKASENFVY-SCAGCCVATYVLGICDRHNDN IMLRSTGHMFHIDFGKFLGHAQMFGSFK--RDRAPFVLTSDMAYVINGG--EK----PTI RFQLFV---------------DLCCQAYNLIRKQTNLFLNLLSLMIPS-GLPELRSIQDL KYVR--DA-LQP-QT-TDAEATIFFTRLIESSL-GSIATKFNFFIHNLAQLRFSGLPSND EPILSFSPKTYSFRQDGRIKEVSVFTYHKKYNPDKHYIYVVRILREGQI-EPSFVFRTFD EFQELHNKLSIIFPLWKLPGFPNRMVLGRTHIKDVAAKRKIELNSYLQSLMNASTDVAEC D-----------LVCTFFHPLLRDEKAEGI-------AR--SADAGSFS-LTPGQIGGAV KLSISYRNGTLFIMVMHIKDLV-TEDGADPNPYVKTYLLPDNHKTSKRKTKISRKTRNPT FNEM--LVYSGYSKETLRQRELQLSVLSAESLRENF-FLGGVTLPLKDFNLSKETVKWYQ LTAATY--L >H_sapiens_ENSP00000265970 ----------MAQISSNSGFKECPSSHPEPTRAKD-VDKEEALQMEAEALAKLQKD-RQV T-----------------------------------------DNQRGF---ELSSSTRKK AQ-VYN------------------KQDYDLMVFPESDSQKRA-----LDIDVEKLTQAEL EKLLLDDSFETKKTPVLPVTPILSPSFSAQLYFRP-----------TIQRGQWPPGLPGP ------------STYAL-------PSIYPS-TY-SKQAAFQNGFNPRMPTFPSTEPIYLS LPG-Q---SPYFSYPLTPATPFHP-QGSL------------------------------- ------------------PIYRPVVSTDMAKLFDKIA-----STSEFLKNGKARTDLEIT DSK--VSNLQVSP--------KSEDIS--------------------------------- ---------------KFDWLDLDPLSKPK-VDNVEVLDHEE--------------EKNVS SLLAKD-------------------PWDAVLLEERSTA---NCHLERKVNG--------- KSLSVATVTRSQSLNIRTTQLA-------------------------------------- -----KAQ-----------GHISQ---KDPNGTSSLPTGS-------SLLQEVEVQNEEM AAFCRSITK---LKTKFPYTNHRT---NPGYLLSPVTAQRN-ICGENA-SVKVSI----- -----------------------DIEGFQLPVTFTCDVSSTVEIIIMQALCWVHDDLNQ- ------------VD-VGSYVLKVCGQEEVLQN-N-HCLGS-HE--HI-QNC-RKWDT-EI RLQLLT--FSAM--CQN-----LARTAEDDETPVDLNKHLYQIEKPCKEAMT-RHPVEEL LDSYHNQVELALQIE-N-------------------QHRAVDQVIKAVRKICSALDG-VE TLAITESV--KKLKRAVNLPRSKTADV-------------TSLFGGEDTSRSSTR-GSL- -------------------NPENPVQVSINQLTAAIYDLLRLHA-NSG-RSPTD------ -CAQSS----KSVKE--------AWTTTEQ-LQFTIFAAHG---------ISSNWVSNYE KYYLICSLSHNGKDLFK-PIQS----KKVGTYK-NFFYLI-KW-DELII-F-PIQISQLP LESVLHLTLFGILN----QSSGS-----------SPDSNKQR-------KGPEALGKVSL PLFDFK-R----------------FLTCGTKLLYLWTSSHT-N------SVPGTVTKKGY VMER------IVLQ-----VDFPSPAF---DIIYTTPQV--------DRSI--------- ------------------------------------------------------------ -----IQQHNLETL---ENDI----KGKLLDIL----HKDSSLGLSKEDKAFLWEK-RYY C-FKHPNCLPKI-LASAPNWKWVNLA---KTY---SLLHQW-----PALYPLIALELLDS KFADQEVRSLAVTWI-EA-ISDDELTDLLPQFVQALKYEIYLNSSLVQFLLSRALG--NI QIAHNLYWLLKDAL-H------D-----------------------VQFSTRYEHVLGAL LSVGGKRLREELLKQTKLVQLLGGVAEKVRQA--S---GSARQ----------------- VVLQRSMERVQS-FF----QKN-KCRLPLKPSLVAKEL-N-IKSCSFFSSNAVPLKVTMV NADPM-----GEEI----NVMF--KVGE--DL-RQDMLALQMIKIMDKIWLKEGLDLRMV IFKCLSTGRDR---GMVELVPASDTLRKIQV---EYGVT-GSFKDKPL--AEWLRKYNPS EE-------------------------EYEKASENFIY-SCAGCCVATYVLGICDRHNDN IMLRSTGHMFHIDFGKFLGHAQMFGSFK--RDRAPFVLTSDMAYVINGG--EK----PTI RFQLFV---------------DLCCQAYNLIRKQTNLFLNLLSLMIPS-GLPELTSIQDL KYVR--DA-LQP-QT-TDAEATIFFTRLIESSL-GSIATKFNFFIHNLAQLRFSGLPSND EPILSFSPKTYSFRQDGRIKEVSVFTYHKKYNPDKHYIYVVRILREGQI-EPSFVFRTFD EFQELHNKLSIIFPLWKLPGFPNRMVLGRTHIKDVAAKRKIELNSYLQSLMNASTDVAEC D-----------LVCTFFHPLLRDEKAEGI-------AR--SADAGSFS-PTPGQIGGAV KLSISYRNGTLFIMVMHIKDLV-TEDGADPNPYVKTYLLPDNHKTSKRKTKISRKTRNPT FNEM--LVYSGYSKETLRQRELQLSVLSAESLRENF-FLGGVTLPLKDFNLSKETVKWYQ LTAATY--L >A_carolinensis_ENSACAP00000007419 -----------MSATRGNGEHWKSLESVGISRKE--LALAEALQMEYDALSRLRQD-KEE S-----------------------------------------Q-AKQ------------- ------------------------NSDQPLISWDDPILD-YNKP-AVRN----DCHNIKV MRSLSGSDSTLNY--NALSGQEVSRAFETSNTTSSTLLP------E-PESQPWLKGPLSS ------------DYLYIYDST--GMTSSMSPSIAH--PARTKLSPPPLPP---------- ------------RIAIWDTSEV------N------------------------------- ------------------QASLKESQPNDINMFSSSQ-----ERPDGKWLGRRISEEDP- ---------YSTV----------------------------------------------- --------------------DYDGINDAI------------------------------T RLNLKS-------------------TYDTELLRDATWS---WKEGRSI--F--------E KESSGKPVARSKTMPPQVPPRT-------------------------------------- -----YISRSGGRKNAALNKNWRISADPATSCHHPVANGY-------ELFEVSEEKDEEV AAFCHMLDV---LRSGYSTKDYSL----TGYVWSAVNLSPE-HLGHGI-SLKVTV----- -----------------------VYDSLQEPLTFTCDCSSTVDLLIYQTLCYTHDELLD- ------------ID-VDDFVLKLCGLEEFLQN-K-QPLGS-HE--YI-QHC-RKFDI-DI RLQLMK--RTAV--RTD-----LARTMNDDQSPSTLNHYVHLQERPIKQTIT-RQALSLL FDTFHNEVDAFLAAEGD-------------------FQLKAERVIQSVMAICNALAA-VE SQEITGAL--NQLPP---CPSRMQPKI------------------------QKDP-NVL- -------------------AMRENREKIVEALTASILDLVELYCNTFN-ADFQT------ -VAHEN-RKHYLSQE--------ACLLSCP-LSFTVYATHR---------IPITWAASYE DFYLSCSLSHGGKELCS-PLQT----RKAHVYK-YLFHLI-IW-DQQIC-F-PIQVNRLP RETLLTATLYAIPV----PPPGS-----------SSEANKQR-------RVPEALGWVTT PLFNFR-K----------------VLTCGRKLLGLWPATQG-S------PSARSSAPNFN QPDS------VILQ-----IDFPSSAF---EVKFTKPPP--------AEFS--------- ------------------------------------------------------------ -----P-QYNFNCL---LEGD----QKKLKEVM----QKESLYWLTDADRKRLWEK-RYY C-HSEPGSLPLL-LASAPSWEWACLP---DIY---ALLKQW-----THMNHQDALGLLHA AFPDQEVRRTAVQWI-DS-ISDAELLDYLPQLVQALKYECYLDSPLVRFLMKRAIC--DL RITHYFFWLLKDGL-K------D-----------------------SQFSIRYQYLLAAL LCCCGKGLREEFDRQCWLVNTLAKLAQQVREA--A---PSSRQ----------------- TILREGLEDVKQ-FF----NVNGSCRLPLSPSLLVKGI-V-PRDCSYFNSNAVPLKLSFQ NVDPL-----GENI----RVIF--KCGD--DL-RQDMLTLQMIRIMNKIWVQEGLDMRMV IFRCFSTGRGR---GMVEMIPNAETLRKIQV---EHGVT-GSFKDRPL--ADWLQKHNPK EN-------------------------EYEKAVENFIY-SCAGCCVATYVLGICDRHNDN IMLKTTGHMFHIDFGRFLGHAQMFGNIK--RDRAPFVFTSDMAYVINGG--DK----PSS RFHDFV---------------DLCCQAYNLIRKHTHLFINLLGLMLSC-GIPELSDLEDL KYVY--DA-LRP-QD-SEADATTYFTRLIESSL-GSVATKLNFFIHNLAQMKFTA--SDT RPTLTFAPRVHTIKTSSRILDVYLCRHEKIFNPSKGYIYIVKVKRENPS-EVSYIQRTFE EFQELHNKLRLIFPSSDLPSFPSRFVIGRSRGEAVAEKRKEELNGYIWHLIHAAPEVAEC D-----------LVYTFFHPLPRDEVAAGTNPV----PK--PADATWS--QPVGKVGGEV KLSVSYKNNKLFIMVMHIRGLQPIQDGSDPDPYVKIYLLPDPQKTTKRKTKVARKTCNPT YNEM--LVYDGIPKGDLHQRELHLSVLSEEGFWENI-LLGEVIIRLRDLDLTQEKMGWFE LGSRSHGTM >G_gallus_ENSGALP00000009863 ----------MAQLSSSNGFKQRSSPSLATARSKD-VDKEEALQMEAEALAKMQKE-RGI A-----------------------------------------GNKQTS---HSLSSTGHV AQ-THS------------------KQDHDLMVFPESDAKRME--DKLSTIDIEKLTHAEL EKLLLDDSFESSKVPALPVTPILSPSLSSQFYIGP-----------TGQRGQWTPGIPAP ------------VTCTL-------PPIYPSASYIKQTSVFQNGFHPSMSSYRSREPIYFG LPR-Q---SQYISYPLAATTPFHP-QGSL------------------------------- ------------------PIYPPVLTPELAKVFDKIA-----STSEFLRNGKSSTDLEMT AIKSAVSSLPASE--------KCRDIS--------------------------------- ---------------KFDWLDLDPLSKPK-VDSVETLYKAE------------DRGEMAS GMTAED-------------------PWDAVLLKEKLLV---TCHLERKING--------- KS-SGATVTRSQSLNMRTTQLG-------------------------------------- -----KLQ-----------GQTSQ---KD-NGTTGTLTEN-------VLLQEMEGQNQEL SAFSQAVTK---LRTKFPYTDQQS---NPGFVLSPIMLQRN-ITGESA-SIKVSI----- -----------------------EIKGFQQPVTFTCDVSSPVELIIMQALCWVHDDLNE- ------------VD-IGSYFLKVCGQEEVLQN-K-HCVGS-HE--YI-QNC-RKWDT-EI KLQLVT--HTEI--CRG-----LARTEEDDSTPIDLTKHLYKVEKPFREPNI-RSSIEEL LDIYHKQIEIALKNE-N-------------------QHKAVDHLIKTVRKICSTLDG-VE TPAITESV--KKLRRAVNLPRIKDTEV--------------SLKCGDDASKSSS--GSL- -------------------QPESPLKVSIDLLTRAVEALVRLHMNSCS-MSSAT------ -VSPED----KTTKE--------AWTATEH-LQFTIFAAHG---------IFPDWVSNFE KYYLICSLTHNGKDLFK-PVQS----KKAGAYK-NFFYLI-KW-DELII-F-PIQISQLP LESVLCLTLFGILN----QSSGS-----------SPDSNKQR-------KGPEMLGQVSL PLFDFR-R----------------LLSCGTKLLQLWTSLHP-S------HASGTASKKEN -MGR------IVLQ-----VDFPSHAF---DIEYKIPQA--------AKTT--------- ------------------------------------------------------------ -----V-HHSIEAL---EKPL----RERLLAIL----SRDNTIGLSKEDKEFLWER-RHY C-HGHTNSLPKI-LASAPHWDWASLP---EIY---SLLQQW-----PPLSPLAALELLDS KFADQEVRNTAVNWI-ET-LSDDELTDFLPQFVQALKYETYLDSALVKFLLARALG--NI RIAHYLYWLLKDTL-Y------D-----------------------PKFGVRYEQILGAF LSVCGKGLREELEKQTRLVLLFGMVAEKVKQT--S---VSGRQ----------------- TALQSGMERVQS-FF----LKN-KCRLPLNPSLVAKEL-N-IKACSFFSSNAVPLKIALI NADPL-----GEEI----NVMF--KVGE--DL-RQDMLALQMIKIMDKIWLQEGLDLRMV IFKCLSTGKDR---GMVELVPASETLRKIQV---EYGVT-GSFKDKPL--AEWLRKYNPT EE-------------------------EYEKASENFIY-SCAGCCVATYVLGICDRHNDN IMLRNTGHMFHIDFGKFLGHAQMFGSFK--RDRAPFVLTSDMAYVINGG--EK----PTI RFQLFV---------------DLCCQAYNLIRKHANLFLNLLSLMLSS-GLPELSGVQDL KYVQ--DA-LQP-QT-TDAEATIFFTRLIESSL-GSVATKFNFFIHNLAQLRFSGLPSND EPILSFSAKTYSLKQDGRIKQVSVFTYQKRYNPDKHYIYVVRVLREGQA-EPTFVFRTFD EFQELHNKLGILFPLWKLPGFPNKMVLGRTHIKDVAAKRKVELNSYIQSLMNSSPEVAEC D-----------LVYTFFHPLLRDDKVEGIDGI----AR--STDASPSS-PTSGKVGGEV KLSISYRNSTLFIMVMHIKDLV-TEDGADPNPYVKTYLLPDTHKTSKRKTKISRKTRNPT FNEM--LVYSGYSVETLKQRELQLSVLSAESLRENF-FLGGITLSLKDFNLSKETVNWYR LTAVPY--L >T_guttata_ENSTGUP00000008892 ----------MAQISSSNGFKQRSSPSLSAPRSKD-VDKEEALQMEAEALAKMQKE-RGV A-----------------------------------------GNKQTF---HSLSSPRQK AQ-AHN------------------KQDHDLMVFPESDAKSME--DKLSTIDIEKLTHAEL EKLLLDDNFESSKVPVLPASPILSPSVSSQFYLGP-----------AGQRRQWTPGIPAP ------------VTCTL-------PPIYTSASYTKQTGVFQNGFHPSMSSYPPREPIYLG LPR-Q---SQYISYPVAATTPFHP-HGAL------------------------------- ------------------PLYPPVLTPEMAKVFDKIA-----STSEFLRNGKSSTDLEMT SIKSAVSNLPASE--------SCGDVS--------------------------------- ---------------KFDWLDLDPLSKPK-VDTVETLNKAE------------DDGERAS SMTAED-------------------PWDAVLLEEKLLL---PCHLERKVNG--------- KS-SGTTVTRSQSLNMRTTQIA-------------------------------------- -----KLQ-----------GQTSQ---KD-NGTTGTLTEN-------VRLQAIEGQNQEL SAFSEAVTK---LRTKFPYTDQQT---NPGFVLSPIMLQRN-ISGESA-SIKVSI----- -----------------------EIEEFQQPVTFTCDVSSPVELIIMQALCWVHDDLNE- ------------VD-IGSYILKVCGQEEVLQN-K-HCIGS-HE--YI-QSC-RKWDT-DI SLQLLT--HSGM--CSD-----LARTVNDDRTPVHLTKHLYKVEKPFREPII-RSSIEEL LEVYHKQVNIALKNE-N-------------------QHKAVDHVIKTVRKICSTLDC-VE TPAITESV--KKLRRAVNLPRIKNAEV--------------SLKCGDDNSKSPS--GSL- -------------------KPLNPLKVSIDQLTRAVEALLQLHTNSCS-SSAAI------ -SPEDS----KSTKE--------AWTATEH-LQFTIFAAHG---------ISSGWVSNYE KYYLICSLTHNGKDLFK-PVQS----KKVGTYK-NFFYLI-KW-DELII-F-PIQISQLP LESVLRLTLFGILN----QSSGS-----------SPDSNKQR-------KGPENLGQVSL PLFDFR-R----------------LLTCGTKLLQLWTSSHP-H------HVSGMASKKGN -MER------IVLQ-----IDFPSHAF---DIEYKIPQA--------SKTT--------- ------------------------------------------------------------ -----V-HHSVETL---EKPL----RERLLAIL----SKDSTIGLSKEDKEFLWEK-RHY C-HSHPNSLPKI-LVSAPHWDWASLP---EIY---SLLQSW-----PPLSPLAALELLDS KFADQEVRNTAVNWI-ET-LSDDELTDFLPQFVQALKYETYLDSALVKFLLARALG--SI RIAHYLYWLLKDTL-Y------D-----------------------TKFGVRYEQILGAF LSVCGKRLREELEKQTRLVQLFGMVAERVKQT--S---GSARQ----------------- VALQNGMERVQL-FF----LKN-KCRLPLNPSLVAKEL-N-IKACSFFSSNAVPLKVALI NADPL-----GEEI----NVMF--KVGE--DL-RQDMLALQMIKIMDKIWLQEGLDLRMV IFKCLSTGKDR---GMVELVPASDTLRKIQV---EYGVT-GSFKDKPL--AEWLRKYNPT EE-------------------------EYEKASENFIY-SCAGCCVATYVLGICDRHNDN IMLRNTGHMFHIDFGKFLGHAQMFGSFK--RDRAPFVLTSDMAYVINGG--EK----PTI RFQLFV---------------DLCCQAYNLIRKHASLFLNLLSLMLSS-GLPELSGVQDL KYVQ--DA-LQP-QT-TDAEATIFFTRLIESSL-GSVATKFNFFIHNLAQLRFSGLPSND EPILSFSAKTYSLKQDGRIKQVSVFTYQKRYNPDKHYIYVVRVLREGQV-EPTFVFRTFD EFQELHNKLGILFPLWKLPGFPNKMVLGRTHIKDVAAKRKVELNSYIQSLMNSSPEVAEC D-----------LVYTFFHPLLRDDKVEGIDGI----AR--PADTSPSS-PTSGKVGGEV KLSISYRNSTLFVMVMHIKDLV-TEDGADPNPYVKTYLLPDMHKTSKRKTKISRKTRNPT FNEMAKLVYSGYSMETLKQRELQLSVLSAESLRENF-FLGGITLPLKDFNLSKETVNWYR LTAVPY--L >G_gorilla_ENSGGOP00000014378 -------------------MELENYKQPVVLREDNCRRRRRMKPRSA---AASLSSME-- ------------------------------------------------------------ ---------------------------LIPIEFVLPT-SQRKC-KSPETALLHVA----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------VQTLDCL RYWK--ATHRSPG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QIHLVQRH----PPSEES----QAFQRQLTXLIGY-------DVTDVSNVHDDEL EFTRRGLVT---PRMAEVASRD----------PKLYAMHPW--VTSKP--LPEYLW-KKI AN---NCIFIV-------------IHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSL- MDIPE-------SQSEQDFVLRVCGRDEYLVG-E-TPIKN-FQ--WV-RHC-LKNGE-EI HVVLDT--PPDP--ALD-----EVRK--EEWP---------------------------L VD----DCTGVTGYHEQ-----------------------------------------LT IHG--KDH---------------------------------------------------- ------------------------------------------------------------ ----ES----VFTVS--------LWDCDRK-FRVKIRGIDIPV-------LPRN---TDL TVFVEANIQHGQQVLCQ-R-RT----SPKPFTE-----EV-LW-NVWLE-F-SIKIKDLP KGALLNLQIYCGKA-PALSSKAS---------AESP--SSES-K-----GKVQLLYYVNL LLIDHR-F----------------LLRRGEYVLHMWQISGKGE-D--QGSFNADKLTSAT NPDKEN---SMSIS-----ILLDNYCH---PIALPKHQP--------TPD---------- ------------------------------------------------------------ -----PEGDRVRAEM--PNQL----RKQLEAII----ATDPLNPLTAEDKELLWHF-RYE SL-KHPKAYPKL-FSSVKWGQQEIVA---KTY---QLLARREVWDQSALDVGLTMQLLDC NFSDENVRAIAVQKL-ES-LEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLR--NK RIGHFLFWFLRSEIAQ------S-----------------------RHYQQRFAVILEAY LRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSL--S---AEKYDVS--------SQXX--- XXXXXXXXXXX--XX----XXXXXXXXXXXXXXXXXXX-X-IEKCKVMASKKKPLWLEFK CADPTAL--SNETI----GIIF--KHGD--DL-RQDMLILQILRIMESIWETESLDLCLL PYGCISTGDKI---GMIEIVKDATTIAKIQ--QSTVGNT-GAFKDEVL--NHWLKEKSPT EE-------------------------KFQAAVERFVY-SCAGYCVATFVLGIGDRHNDN IMITET------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >P_troglodytes_ENSPTRP00000003161 -----------MSSTQGNGEHWKSLESVGISRKE--LAMAEALQMEYDALSRLRHD-KEE N-----------------------------------------R-AKQ------------- ------------------------NADPSLISWDEPGVDFYSKP-AGRR----T--DLKL LRGLSGSDPTLNY--NSLSPQEGPPNHSTSQG------P------Q-PGSDPWPKGSLSG ------------DYLYIFDGSDGGVSSSPGPGDIE--GSCKKLSPPPLPP---------- ------------RASIWDTPPLPP-RKGS------------------------------- ------------------PSSSKISQPSDINTFSLVE-----Q-LPGKLLEHRILEEEEV PGGGGQGRLLGSV----------------------------------------------- --------------------DYDGINDAI------------------------------T RLNLKS-------------------TYDAEMLRDATRG---WKEGRGPLDF--------S KDTSGKPVARSKTMPPQVPPRT-------------------------------------- -----YASRYGNRKNATPGKNRRISAAPVGSRPHTVANGH-------ELFEVSEERDEEV AAFCHMLDI---LRSGSDIQDYFL----TGYVWSAVTPSPE-HLGDEV-NLKVTV----- -----------------------LCDRLQEALTFTCNCSSTVDLLIYQTLCYTHDDLRN- ------------VD-VGDFVLKPCGLEEFLQN-K-HALGS-HE--YI-QYC-RKFDI-DI RLQLME--QKVV--RSD-----LARTVNDDQSPSTLNYLVHLQERPVKQTIS-RQALSLL FDTYHNEVDAFLLADGD-------------------FPLKADRVVQSVKAICNALAA-VE TPEITNAL--NQLPP---CPSRMQPKI------------------------QKDP-SVL- A-------------------VRENREKVVEALTAAILDLVELYCNTFN-ADFQT------ -AVPGS-RKHDLVQE--------ACHFARS-LAFTVYATHR---------IPIIWATSYE DFYLSCSLSHGGKELCS-PLQT----RRAHFSK-YLFHLI-VW-DQQIC-F-PVQVNRLP RETLLCATLYALPI----PPPGS-----------SSEANKQR-------RVPEALGWVTT PLFNFR-Q----------------VLTCGRKLLGLWPATQE-N------PSARWSAPNFH QPDS------VILQ-----IDFPTSAF---DIKFTSPPG--------DKFS--------- ------------------------------------------------------------ -----P-RYEFGSL---REED----QRKLKDIM----QKESLYWLTDADKKRLWEK-RYY C-HSEVSSLPLV-LASAPSWEWACLP---DIY---ALLKQW-----THMNHQDALGLLHA TFPDQEVRRMAVQWI-GS-LSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVS--DL RVTHYFFWLLKDGL-K------D-----------------------SQFSIRYQYLLAAL LCCCGKGLREEFNRQCWLVNALAKLAQQVREA--A---PSARQ----------------- GILRIGLEEVKQ-FF----ALNGSCRLPLSPSLLVKGI-V-PRDCSYFNSNAVPLKLSFQ NVDPL-----GENI----RVIF--KCGD--DL-RQDMLTLQMIRIMSKIWVQEGLDMRMV IFRCFSTGRGR---GMVEMIPNAETLRKIQV---EHGVT-GSFKDRPL--ADWLQKHNPG ED-------------------------EYEKAVENFIY-SCAGCCVATYVLGICDRHNDN IMLKTTGHMFHIDFGRFLGHAQMFGNIK--RDRAPFVFTSDMAYVINGG--DK----PSS RFHDFV---------------DLCCQAYNLIRKHTHLFLNLLGLMLSC-GIPELSDLEDL KYVY--DA-LRP-QD-TEANATTYFTRLIESSL-GSVATKMNFFIHN------------- -------AQTHTLKSSGRISDVFLCXHEKIFHPNKGYIYVVKVMRENTH-EATYIQRTFE EFQELHNKLRLLFPSSHLPSFPSRFVIGRSRGEAVAERRREELNGYIWHLIHAPPEVAEC D-----------LVYTFFHPLPRDEKAMGTSPA----PK--SSDGTWA--RPVGKVGGEV KLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARKTCNPT YNEM--LVYDGIPKGDLQQRELQLSVLSEQGFWENV-LLGEVNIRLRELDLAQEKTGWFA LGSRSHGTL >M_musculus_ENSMUSP00000076911 -----------MSSTQGNGEHWKSLESVGISRKE--LAMAEALQMEYDALSRLRHH-KEE S-----------------------------------------R-AKQ------------- ------------------------NTEPSLISWDEPALDFYSKP-AGRR----T--DLKL LRGLSGSDPTLNY--NSISPPEGLPN-STSQD------P------Q-PGPDPWPKGSLSG ------------DYLYIFDGSEGRCSLSPGSGDTD--GSCKKLSPPPLPP---------- ------------RVSIWDAPPLPP-RKGS------------------------------- ------------------PSPSKISQPNDINSFSSAE-----Q-PPDKLLVAQDPEEGEL PDGRGQGHTLGSV----------------------------------------------- --------------------DYDGINDAI------------------------------T RLNLKS-------------------TYDSEISSDATRG---WKEGRGPLDF--------N KDTSGKPVARSKTMPPQVPPRT-------------------------------------- -----YTSRYANRKNATPGNNRRISAAPVGSRPHTVANGH-------ELFEVSEERDEEV AAFCHMLDI---LRTGSDIQDYSL----TGCVWSTVTPSPE-HLGDEV-NLKVTV----- -----------------------LCDSLREPLTFTCNCSSTVDLLIHQTLCYTHDELRE- ------------VD-VGDFVLKPCGLEEFLQN-K-HALGS-HE--YI-QYC-RKFDI-SI RLQLME--QKAI--RSD-----LARTVNDDQSPSTLNYLIHLQERPVKQTIS-RQALSLL FDTYHNEVDAFLLADGD-------------------FPLKADRVVQSVKAICNALAA-VE TPEITSAL--NQLPP---CPSRMQPKI------------------------QKDP-SVL- S-------------------VRENREKVVEALTAAILDLVELYCSTFN-ADFQT------ -AVPGS-RKHDLVQE--------ACHFPGA-LAFTVYGTHR---------IPIIWATSYE DFYLSCSLSHGGKELCS-PLQT----RRAHFSK-YLFHLI-IW-DQQIC-F-PVQVNRLP RETLLCATLYALPV----PPPGG-----------SSEANKQK-------RVPEALGWVTT PLFNFR-Q----------------VLTCGRKLLGLWPATQE-N------SGARWSAPNFH QPDS------VILQ-----IDFPSSAF---DIKFTSPPG--------DKFS--------- ------------------------------------------------------------ -----P-RYEFGSL---REED----QRKLKDIT----QKESLYWLTDADKKQLWEK-RYY C-HTEVSSLPLV-LASAPSWEWACLP---DIY---ALLQQW-----THMNHQDALGLLHA TFPDQEVRRMAVQWI-GS-LSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAIS--DL RVTHYFFWLLKDSL-K------D-----------------------SQFSIRYQYLLAAL LCCCGKGLREEFNRQCWLVNTLAKLAQQVREA--T---PSARQ----------------- GILRVGLEEVKQ-FF----ALNGSCRLPLSPSLLVKGI-V-PRDCSYFNSNAVPLKLAFQ NVDPL-----GENI----RVIF--KCGD--DL-RQDMLTLQMIRIMSKIWVQEGLDMRMV IFRCFSTGRGK---GMVEMIPNAETLRKIQV---EHGVT-GSFKDRPL--ADWLQKHNPG ED-------------------------EYEKAVENFIY-SCAGCCVATYILGICDRHNDN IMLKTTGHMFHIDFGRFLGHAQMFGNIK--RDRAPFVFTSDMAYVINGG--DK----PSS RFHDFV---------------DLCCQAYNLIRKHTHLFLNLLGLMLSC-GIPELSDLEDL KYVY--DA-LRP-QD-TEANATTYFTRLIESSL-GSVATKLNFFIHNLAQMKFTG--SDD RLTLSFAPRTHTLKSSGRIRDVFLCRHEKIFHPSKGYVYVVKVMRENAH-EATYIQRTFE EFQELHNKLRLLFPSSFLPSFPSRFVIGRSRGEAVAERRKEELNGYIWHLIHAAPEVAEC D-----------LVYTFFHPLPRDEKASGPSPA----PK--SSDGTWA--RPVGKVGGEV KLSISYKNNKLFIMVMHIRGLQPLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARKTCNPT YNEM--LVYDGIPKGDLQQRELQLSVLSEQGFWENL-LLGEVHIRLRELDLAQEKTGWFG LGSRGHGT- >P_pygmaeus_ENSPPYP00000000347 -----------MSSTQGNGEHWKSLESVGISRKE--LAMAEALQMEYDALSRLRHD-KEE N-----------------------------------------R-AKQ------------- ------------------------NADPSLISWDEPGVDFYSKP-AGRR----T--DLKL LRGLSGSDPTLNY--NSLSPQEGPPNHSTSQG------P------Q-PGSDPWPKGSLSG ------------DYLYIFDGSDGGVSSSPGPGDIE--SSCKKLSPPPLPP---------- ------------RASIWDTPPLPP-RKGS------------------------------- ------------------PSSSKISQPNDINTFSLVE-----Q-LPGKLLEHRILEEEEV PGGGGQGRLLGSV----------------------------------------------- --------------------DYDGINDAI------------------------------T RLNLKS-------------------TYDAEMLRDATRG---WKEGRGPLDF--------S KDTSGKPVARSKTMPPQVPPRT-------------------------------------- -----YAARYGNRKNATPGKNRRISAAPVGSRPHTVANGH-------ELFEVSEERDEEV AAFCHMLDI---LRSGSDIQDYSL----TGYVWSAVTPSPE-HLGDEV-NLKVTV----- -----------------------LCDRLQEALTFTCNCSSTVDLLIYQTLCYTHDDLRN- ------------VD-VGDFVLKPCGLEEFLQN-K-HALGS-HE--YI-QYC-RKFDI-DI RLQLME--QKVV--RSD-----LARTVNDDQSPSTLNYLVHLQERPVKQTIS-RQALSLL FDTYHNEVDAFLLADGD-------------------FPLKADRVVQSVKAICNALAA-VE TPEITNAL--NQLPP---CPSRMQPKI------------------------QKDP-SVL- A-------------------VRENREKVVEALTAAILDLVELYCNTFN-ADFQT------ -AVSGS-RKHDLVQE--------ACHFARS-LAFTVYATHR---------IPIIWATSYE DFYLSCSLSHGGKELCS-PLQT----RRAHFSK-YLFHLI-IW-DQQIC-F-PVQVNRLP RETLLCATLYALPI----PPPGS-----------SSEANKQR-------RVPEALGWVTT PLFNFR-Q----------------VLTSGRKLLGLWPATQE-N------PSARWSAPNFH QPDS------VILQ-----IDFPTSAF---DIKFTSPPG--------DKFS--------- ------------------------------------------------------------ -----P-RYEFGSL---REED----QRKLKDIM----QKESLYWLTDADKKRLWEK-RYY C-HSEVSSLPLV-LASAPSWEWACLP---DIY---ALLKQW-----THMNHQDALGLLHA TFPDQEVRRMAVQWI-GS-LSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVS--DL RVTHYFFWLLKDGL-K------D-----------------------SQFSIRYQYLLAAL LCCCGKGLREEFNRQCWLVNALAKLAQQVREA--A---PSARQ----------------- GILRTGLEEVKQ-FF----ALNGSCRLPLSPSLLVKGI-V-PRDCSYFNSNAVPLKLSFQ NVDPL-----GENI----RVIF--KCGD--DL-RQDMLTLQMIRIMSKIWVQEGLDMRMV IFRCFSTGRGR---GMVEMIPNAETLRKIQV---EHGVT-GSFKDRPL--ADWLQKHNPG ED-------------------------EYEKAVENFIY-SCAGCCVATYVLGICDRHNDN IMLKTTGHMFHIDFGRFLGHAQMFGNIK--RDRAPFVFTSDMAYVINGG--DK----PSS RFHDFV---------------DLCCQAYNLIRKHTHLFLNLLGLMLSC-GIPELSDLEDL KYVY--DA-LRP-QD-TEANATTYFTRLIESSL-GSVATKLNFFIHNLAQMKFTG--SDD RLTLSFASRTHTLKSSGRISDVFLCRHEKIFHPNKGYIYVVKVMRENTH-EATYIQRTFE EFQELHNKLRLLFPSSHLPSFPSRFVIGRSRGEAVAERRREELNGYIWHLIHAPPEVAEC D-----------LVYTFFHPLPRDEKAMGTSPA----PK--SSDGTWA--RPVGKVGGEV KLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARKTCNPT YNEM--LVYDGIPKGDLQQRELQLSVLSEQGFWENV-LLGEVNIRLRELDLAQEKTGWFA LGSRSHGTL >R_norvegicus_ENSRNOP00000051488 SSSSPVPLALIMSSTQGNGEHWKSLESVGISRKE--LAMAEALQMEYDALSRLRHH-KEE S-----------------------------------------R-AKQ------------- ------------------------NTEPSLISWDEPALDFYSKP-AGRR----T--ELKL LRGLSGSDPTLNY--NSISPPEELPN-STSQD------P------Q-PGTDPWPKGSQSG ------------DYLYIFDGSDGRCSLSPVSGDTD--GSCKKLSPPPLPP---------- ------------RVSIWDAPPLPP-RKGS------------------------------- ------------------PSPSKISQPDDINSFSLVE-----Q-PSDKLLGAQDPGEGEL PNGGGQRHVLGSV----------------------------------------------- --------------------DYDGINDAI------------------------------T RLNLKS-------------------TYDSEILSDATRG---WKEGRGPLDF--------S KDTSGKPVARSKTMPPQVPPRT-------------------------------------- -----YTPRYANRKNATPGKNRRISAAPVSSRTHTVTNGH-------ELFEVSEERDEEV AAFCHMLDI---LRTGSDTQDYSL----TGCVWSTVTPSPE-HLGDEV-NLKVTV----- -----------------------LCDSLREPLTFTCNCSSTVDLLIYQTLCYTHDELRE- ------------VD-VGDFVLKPCGLEEFLQN-K-HALGS-HE--YI-QHC-RKFDI-NI RLQLME--QKAI--RSD-----LARTVNDDQSPSTLNYLIHLQERPVKQTIS-RQALSLL FDTYHNEVDAFLLAEGD-------------------FPLKADRVVQSVKAICNALAA-VE TPEITSAL--NQLPP---CPSRMQPKI------------------------QKDP-SVL- T-------------------VRENREKVVEALTAAILDLVELYCSTFN-ADFQT------ -AVPGS-RKHDLVQE--------ACHFSGA-LAFTVYGTHR---------IPIIWATSYE EFYLSCSLSHGGKELCS-PLQT----RRAHFSK-YLFHLI-IW-DQQIC-F-PVQVNRLP RETLLCATLYALPI----PPPGS-----------SSEANKQK-------RVPEALGWVTT PLFNFR-Q----------------VLTCGRKLLGLWPATQE-N------SSARWSAPNFH QPDS------VILQ-----IDFPTSAF---DIKFTSPPG--------DKFS--------- ------------------------------------------------------------ -----P-RYEFGSL---REED----QRKLKDIT----QKESLYWLSDADKKQLWEK-RYY C-HTEVSSLPLV-LASAPSWEWACLP---DIY---ALLQQW-----THMNHQDALGLLHA TFPDQEVRRMAVQWI-GS-LSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAIS--DL RVTHYFFWLLKDSL-K------D-----------------------SQFSIRYQYLLAAL LCCCGKGLREEFNRQCWLVNTLAKLAQQVREA--T---PSARQ----------------- GILRAGLEEVRQ-FF----ALNGSCRLPLSPSLLVKGI-V-PRDCSYFNSNAVPLKLAFQ NVDPL-----GENI----RVIF--KCGD--DL-RQDMLTLQMIRIMSKIWVQEGLDMRMV IFRCFSTGRGK---GMVEMIPNAETLRKIQV---EHGVT-GSFKDRPL--ADWLQKHNPG ED-------------------------EYEKAVENFIY-SCAGCCVATYILGICDRHNDN IMLKTTGHMFHIDFGRFLGHAQMFGNIK--RDRAPFVFTSDMAYVINGG--DK----PSS RFHDFV---------------DLCCQAYNLIRKHTHLFLNLLGLMLSC-GIPELSDLEDL KYVY--DA-LRP-QD-TEANATTYFTRLIESSL-GSVATKLNFFIHNLAQMKFTG--SDD RLTLSFAPRTHTLKSSGRIRDVFLCRHEKVFHPSKGYIYVVKVMRENAH-EATYIQRTFE EFQELHNKLRLLFPSSFLPSFPSRFVIGRSRGEAVAERRKEELNGYIWHLIHAAPEVAEC D-----------LVYTFFHPLPRDEKTSGPSPA----PK--SSDGTWA--RPVGKVGGEV KLSISYKNNKLFIMVMHIRGLQPLQDGSDPDPYVKIYLLPDPQKATKRKTKVARKTCNPT YNEM--LVYDGIPKGDLQQRELQLSVLSEQGFWENV-LLGEVHIRLRELDLAQEKTGWFA LGSRGHGTL >H_sapiens_ENSP00000356155 -----------MSSTQGNGEHWKSLESVGISRKE--LAMAEALQMEYDALSRLRHD-KEE N-----------------------------------------R-AKQ------------- ------------------------NADPSLISWDEPGVDFYSKP-AGRR----T--DLKL LRGLSGSDPTLNY--NSLSPQEGPPNHSTSQG------P------Q-PGSDPWPKGSLSG ------------DYLYIFDGSDGGVSSSPGPGDIE--GSCKKLSPPPLPP---------- ------------RASIWDTPPLPP-RKGS------------------------------- ------------------PSSSKISQPSDINTFSLVE-----Q-LPGKLLEHRILEEEEV LGGGGQGRLLGSV----------------------------------------------- --------------------DYDGINDAI------------------------------T RLNLKS-------------------TYDAEMLRDATRG---WKEGRGPLDF--------S KDTSGKPVARSKTMPPQVPPRT-------------------------------------- -----YASRYGNRKNATPGKNRRISAAPVGSRPHTVANGH-------ELFEVSEERDEEV AAFCHMLDI---LRSGSDIQDYFL----TGYVWSAVTPSPE-HLGDEV-NLKVTV----- -----------------------LCDRLQEALTFTCNCSSTVDLLIYQTLCYTHDDLRN- ------------VD-VGDFVLKPCGLEEFLQN-K-HALGS-HE--YI-QYC-RKFDI-DI RLQLME--QKVV--RSD-----LARTVNDDQSPSTLNYLVHLQERPVKQTIS-RQALSLL FDTYHNEVDAFLLADGD-------------------FPLKADRVVQSVKAICNALAA-VE TPEITSAL--NQLPP---CPSRMQPKI------------------------QKDP-SVL- A-------------------VRENREKVVEALTAAILDLVELYCNTFN-ADFQT------ -AVPGS-RKHDLVQE--------ACHFARS-LAFTVYATHR---------IPIIWATSYE DFYLSCSLSHGGKELCS-PLQT----RRAHFSK-YLFHLI-VW-DQQIC-F-PVQVNRLP RETLLCATLYALPI----PPPGS-----------SSEANKQR-------RVPEALGWVTT PLFNFR-Q----------------VLTCGRKLLGLWPATQE-N------PSARWSAPNFH QPDS------VILQ-----IDFPTSAF---DIKFTSPPG--------DKFS--------- ------------------------------------------------------------ -----P-RYEFGSL---REED----QRKLKDIM----QKESLYWLTDADKKRLWEK-RYY C-HSEVSSLPLV-LASAPSWEWACLP---DIY---VLLKQW-----THMNHQDALGLLHA TFPDQEVRRMAVQWI-GS-LSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVS--DL RVTHYFFWLLKDGL-K------D-----------------------SQFSIRYQYLLAAL LCCCGKGLREEFNRQCWLVNALAKLAQQVREA--A---PSARQ----------------- GILRTGLEEVKQ-FF----ALNGSCRLPLSPSLLVKGI-V-PRDCSYFNSNAVPLKLSFQ NVDPL-----GENI----RVIF--KCGD--DL-RQDMLTLQMIRIMSKIWVQEGLDMRMV IFRCFSTGRGR---GMVEMIPNAETLRKIQV---EHGVT-GSFKDRPL--ADWLQKHNPG ED-------------------------EYEKAVENFIY-SCAGCCVATYVLGICDRHNDN IMLKTTGHMFHIDFGRFLGHAQMFGNIK--RDRAPFVFTSDMAYVINGG--DK----PSS RFHDFV---------------DLCCQAYNLIRKHTHLFLNLLGLMLSC-GIPELSDLEDL KYVY--DA-LRP-QD-TEANATTYFTRLIESSL-GSVATKLNFFIHNLAQMKFTG--SDD RLTLSFASRTHTLKSSGRISDVFLCRHEKIFHPNKGYIYVVKVMRENTH-EATYIQRTFE EFQELHNKLRLLFPSSHLPSFPSRFVIGRSRGEAVAERRREELNGYIWHLIHAPPEVAEC D-----------LVYTFFHPLPRDEKAMGTSPA----PK--SSDGTWA--RPVGKVGGEV KLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARKTCNPT YNEM--LVYDGIPKGDLQQRELQLSVLSEQGFWENV-LLGEVNIRLRELDLAQEKTGWFA LGSRSHGTL >C_elegans_B0334.8 -----------------------------MHVNILHPQLQTMVEQWQMRERPSLETENGK G----------------------------------------------------------- -------------------SLLLENEGVADIITMCPFGEVISVVFPWFLANVRTSLEIKL SDFK-HQLFELIAPMKWG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------TYS---VKPQDYVFRQLNN---FGEIEVIFNDDQPLSKLELH GTFP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MLFLYQPD-----GINRD----KELMSDISHCLGY-------SLDKLEESLDEEL RQFRASLWA---RTKKTCLTRG-------LEGTSHYAFPEEQYLCVGE-SCPKDLE-SKV KA---AKLSYQMFWRKRKAEIN-GVCEKMMKIQIEFNPNETPKSLLHTFLYEMR---KLD VYDTD-------DPADEGWFLQLAGRTTFVTNPD-VKLTS-YD--GV-RSE-LESYR-CP GFVVRR--QSLV--LKD-----YCRPKPLYEPHYVRAHERKLA----------LDVLSVS ID----STPKQSKNSDM-----------------------------------------VM TDFRPTA----------------------------------------------------- ------------------------------------------------------------ -----S----LKQVS--------LWDLDAN-LMIRPVNISGFD-------FPAD---VDM YVRIEFSVYVGTLTLAS---KS----TTKVNAQ-----FA-KW-NKEMYTF-DLYMKDMP PSAVLSIRVLYG------KVKLK--------------------------SEEFEVGWVNM SLTDWR-D----------------ELRQGQFLFHLWAPEPTAN----RSRIGENGARIGT N---------AAVT-----IEISSYGG---RVRMPSQGQ--------YTYLVKHR----- -----------------------------------------------STWTETLN----- -----IMGDDYESCI--RDPG----YKKLQMLVK---KHESGIVLEEDEQRHVWMW-RRY IQKQEPDLLIVLSELAFVWTDRENFS---ELY---VMLEKW-----KPPSVAAALTLLGK RCTDRVIRKFAVEKL-NEQLSPVTFHLFILPLIQALKYEPRAQSEVGMMLLTRALC--DY RIGHRLFWLLRAEIARLRDCDLK-----------------------SEEYRRISLLMEAY LRGNE-EHIKIITRQVDMVDELTRISTLVKGM--P---KDVAT----------------- MKLRDELRSIS--------HKMENMDSPLDPVYKLGEM-I-IDKAIVLGSAKRPLMLHWK NKNPK-----SDLHLPFCAMIF--KNGD--DL-RQDMLVLQVLEVMDNIWKAANIDCCLN PYAVLPMGEMI---GIIEVVPNCKTIFEIQVGTGFMNTAVRSIDPSFM--NKWIRKQCGI EDEKKKSKKDSTKNPIEKKIDNTQAMKKYFESVDRFLY-SCVGYSVATYIMGIKDRHSDN LMLTEDGKYFHIDFGHILGHGKTKLGIQ--RDRQPFILTEHFMTVIRSG--KSVDG-NSH ELQKFK---------------TLCVEAYEVMWNNRDLFVSLFTLMLGM-ELPELSTKADL DHLK--KT-LFCNGE-SKEEARKFFAGIYEEAFNGSWSTKTNWLFHAVK----------- -----------------------------------------------HY----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >E_caballus_ENSECAP00000013120 -SLSPLSPILTMSSTQGNGEHWKSLESVGISRKE--LAMAEALQMEYDALSQLRHD-KEE S-----------------------------------------R-AKQ------------- ------------------------NTDPSLISWDEPVLDFYSKP-AGRR----K--DFKL LRGLSGSDPTLNY--NSVSPQERPPNHSTSQG------S------Q-PGPDPWPKGSLAG ------------DYLYIFDGSDGGLSLSPGPGDVD--GSSKKLSPPPLPP---------- ------------RVSIWDNPPLPP-RKGS------------------------------- ------------------PSSSKIFQPNDINTLSLIE-----Q-PPGKLLGHRILEEEEE RGGGGPGPLLACV----------------------------------------------- --------------------DYDGINDAI------------------------------T RLNLKS-------------------TYDAEMLRDTTRG---WKEGRGPLDF--------G KDTPGKPVARSKTMPPQVPPRT-------------------------------------- -----YASRYANRKNATPGTNHRISAAPVGSRPHAVANGH-------ELFEVSEERDEEV AAFCHMLDI---LRSGSDVQDYSL----TGYVWSAVTPSPE-HLGDEV-NLKVTV----- -----------------------LCDSLREPLTFTCNCSSTVDLLIYQTLCYTHDELRD- ------------VD-VGDFVLKPCGLEEFLQN-K-HALGS-HE--YI-QYC-RKFDI-DI RLQLME--QKAV--HSD-----LARTVNDDQSPSTLNYLIHLQERPVKQTIS-RQALSLL FDTYHNEVDAFLLTDGD-------------------FPLKADRVVQSVKAICNALAA-VE TPEITSAL--NQLPP---CPSRMQPKI------------------------QKDP-TVL- A-------------------VRENREKVVEALTAAILDLVELYCNAFN-ADFQT------ -AVHGS-HKHDLVQE--------ACHFSGP-LAFTVYATHR---------IPITWATSYE DFYLSCSLSHGGKELCS-PLQT----RRAHFSK-YLFHLI-IW-DQQIC-F-PVQVNRLP RETLLCATLYALPI----PPAGG-----------SSEANKQR-------RVPEALGWVTT PLFNFR-Q----------------VLTCGRKLLGLWPATQE-N------PSARWSAPNFH QPDS------VILQ-----IDFPTSAF---DIKFTSPPG--------DKFS--------- ------------------------------------------------------------ -----P-RYEFGSL---REED----QRVLKNIM----QKESLYWLTDADKKRLWEK-RYY C-HSEVSSLPLV-LASAPSWEWACLP---DTY---ALLKQW-----THMNHQDALGLLHA TFPDQEVRRMAVQWI-GS-LSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVS--DL RVTHYFFWLLKDGL-K------D-----------------------SQFSIRYQYLLAAL LCCCGKGLREEFNRQCCLVSTLAKLAQQVREA--T---PSVRQ----------------- GILRSGLEEVRQ-FF----TLNGSCRLPLSPSLLVKGI-V-PRDCSYFNSNAVPLKLSFQ NVDPL-----GENI----RVIF--KCGD--DL-RQDMLTLQMIRIMSKIWVQEGLDMRMV IFRCFSTGRGR---GMVEMIPNAETLRKIQV---EHGVT-GSFKDRPL--ADWLQKHNPG EE-------------------------EYEKAVENFIY-SCAGCCVATYVLGICDRHNDN IMLKTTGHMFHIDFGRFLGHAQMFGNIK--RDRAPFVFTSDMAYVINGG--DK----PSS RFHDFV---------------DLCCQAYNLIRKHTHLFLNLLGLMLSC-GIPELSDLEDL KYVY--DA-LRP-QD-TEANATTYFTRLIESSL-GSVATKLNFFIHNLAQMKFTG--SDD RLALSFAPRTYTVKSSGRISDVFLCRHEKIFYPNKGYVYVVKVMRENAH-EATYIQRTFE EFQELHNKLRLLFPSSFLPSFPSRFVIGRSRGEAAAERRREELNGYIWHLIHAAPEVAEC D-----------LVCTFFHPLPRDEKAAGTSPA----PK--SSDGSWA--RPIGKVGGEV KLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKKKTKVARKTCNPT YNEM--LVYDGIPKGDLQQRELQLSVLSEQGLWENV-LLGEVRIRLRELDLAQEKAGWFA LGSRSQETS >M_mulatta_ENSMMUP00000029682 ----------MAQISSNSGFKECPSSHPEPTRAKD-VDKEEALQMEAEALAKLQKD-RQV T-----------------------------------------DNQRGF---ELSSSTRKK AQ-VNN------------------KQDYDLMVFPESDSQKRA-----LDIDVEKLTQAEL EKLLLDDSFETRKTPVLPATPVLSPSFSAQLYFRP-----------TIQRGQWPPGLSGP ------------STYTL-------PSIYPS-TY-SKQAAFQNGFNPRMPTFPSTEPIYLS LPG-Q---SPYFSYPLTPATPFHP-QGSL------------------------------- ------------------PIYRPVVSPDMAKLFDKIA-----STSEFLKNGKARTDLEIT DSK--VSSLQVSP--------KSEDIS--------------------------------- ---------------KFDWLDLDPLSKPK-VDNVEVLDHEE--------------EKNIS SLLAKD-------------------PWDAVLLEERLPA---NCHLERKVNG--------- KSLSVATVTRSQSLNIRTTQLA-------------------------------------- -----KAQ-----------GHIFQ---KDPNGTSNLPTGS-------SLLQEVEVQNEEM AAFCRSITK---LKTKFPYTNHRT---NPGYLLSPVTAQRN-ICGENA-SVKVSI----- -----------------------EIEGFQLPVTFTCDVSSTVEIIIMQALCWVHDDLNQ- ------------VD-VGSYVLKVCGQEEVLQN-NMHCYFM-HS--SQ-QNT-LYMSE-NI RLSMLS--FEVK--CMN-----LWNDAEDDETPVDLNKHLHQIEKPYKEAMT-RHPVEEL LDSYHNQVEVALQIE-N-------------------QHRAVDQVIKAVRKICSALDG-VE TLAITESV--KKLKRAVNLPRSKTADV-------------TSLFGEDDTSKKSTRVGSL- -------------------NPENPVQVSINQLTAAIYDLLRLHA-KFC-QKQEN------ -IAGKQ----SNCKE--------DWLNASQNLQWSNF--RW---------ISKNSSESYE KYYLICSLSHNGKDLFK-PIQS----KKVGTYK-NFFYLI-KW-DELII-F-PIQISQLP LESLLHLTLFGILN----QSSGS-----------SPDSNKQR-------KGPEALGKVSL PLFDFK-R----------------FLTCGTKLLYLWTSSHT-N------SVPGTVTKKGY VMER------IVLQ-----VDFPSPAF---DVIYTTPQV--------DRSI--------- ------------------------------------------------------------ -----IQQHNLETL---ENDI----KGKLLDIL----HKDSSLGLSKEDKAFLWEK-RYY C-FKHPNCLPKI-LASAPNWKWVNLA---KTY---SLLHQW-----PPLYPLIALELLDS KFADQEVRSLAVTWI-EA-ISDDELTDLLPQFVQALKYEIYLNSPLVQFLLSRALG--NI QIAHNLYWLLKDAL-H------D-----------------------VQFSTRYEHVLGAL LSVGGKRLREELLKQTKLVQLLGGVAEKVRQA--S---GSARQ----------------- VVLQRSMERVQS-FF----QKN-KCRLPLKPSLVAKEL-N-IKSCSFFSSNAVPLKVTMV NADPM-----GEEI----NVMF--KVGE--DL-RQDMLALQMIKIMDKIWLKEGLDLRMV IFKCLSTGRDRVK-GMVELVPASDTLRKIQV---EYGVT-GSFKDKPL--AEWLRKYNPS EE-------------------------EYEKASENFIY-SCAGCCVATYVLGICDRHNDN IMLRSTGHMFHIDFGKFLGHAQMFGSFK--RDRAPFVLTSDMAYVINGG--EK----PTI RFQLFV---------------DLCCQAYNLIRKQTNLFLNLLSLMIPS-GLPELTSIQDL KYVR--DA-LQP-QT-TDAEATIFFTRLIESSL-GSIATKFNFFIHNLAQLRFSGLPSND EPILSFSPKTYSFRQDGRIKEVSVFTYHKKYNPDKHYIYVVRILREGQI-EPSFVFRTFD EFQELHNKLSIIFPLWKLPGFPNRMVLGRTHIKDVAAKRKIELNSYLQSLMNASTDVAEC D-----------LVCTFFHPLLRDEKAEGI-------AR--SADAGSFS-PTPGQIGGAV KLSISYRNGTLFIMVMHIKDLV-TEDGADPNPYVKTYLLPDNHKTSKRKTKISRKTRNPT FNEM--LVYSGYSKETLRQRELQLSVLSAESLRENF-FLGGVTLPLKDFNLSKETVKWYQ LTAATY--L >B_taurus_ENSBTAP00000017388 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GH-------ELFEVSEERDEEV AAFCHMLDV---LRSGSDVQDYAL----TGYVWSAVTPSPE-HLGDEV-NLKVTV----- -----------------------LCDSLREPLTFTCNCSSTVDLLIYQTLCYTRDELRD- ------------VD-VGDFVLKPCGLEEFLQN-K-HALGS-HE--YI-QYC-RKFGI-DI RLQLME--QKAV--RGD-----LARTVNDDQSPSTLNYLVHLQERPVKQTIS-RQALSLL FDTYHNEVDAFLLADGD-------------------FPLKADRVVQSVKAICNALAA-VE TPEITSAL--NQLPP---CPSRVKPKI------------------------QKD--CIL- ACFGGCDDCIMARLGGHNDCIVARLEKVVEALTAAILDLVELYCNTFN-ADFQP------ -AVPGS-RKHTLVQE--------ACHLSGP-LAFTVYATHR---------IPITWATSYE EFYLSCSLSHGGKELCS-PLQT----RRVHFSK-YLFHLV-IW-DQQIC-F-PVQLNRLP RETLLCATLYALPV----PPPGS-----------SSEANKQR-------RVPEALGWVTA PLFNFR-Q----------------VLTCGRKLLGLWPATQE-S------PSARWSAPNFH QPDS------VILQ-----IDFPTSAF---DIKFTSPAG--------DKFS--------- ------------------------------------------------------------ -----P-RYEFGSL---REED----QHVLKNIM----QKESLHWLTDADKKRLWEK-RYY C-HAEVSALPLV-LASAPSWEWACLP---DTY---ALLAQW-----TPMNHQDALGLLHA TFPDQEVRRMAVQWI-GS-LSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVS--DL RVTHYFFWLLKDGL-K------D-----------------------SQFSIRYQYLLAAL LCCCGKGLREEFNRQCWLVNTLAKLAQQVREA--A---PSARQ----------------- -VRRARL------------PLPHSGSGPLQP----------IQDCSYFNSNAVPLKLSFQ NVDPL-----GENI----RVIF--KCGD--DL-RQDMLTLQMIRIMSKIWVQEGLDMRMV IFRCFSTGRGR---GMVEMIPNSETLRKIQV---EHGVT-GSFKDRPL--ADWLQKHNPG ED-------------------------EYEKAVENFIY-SCAGCCVATYVLGICDRHNDN IMLKTTGHMFHIDFGRFLGHAQMFGNIK--RDRAPFVFTSDMAYVINGG--DK----PSS RFHDFV---------------DLCCQAYNLIRKHTHLFLNLLGLMLSC-GIPELSDLEDL KYVY--DA-LRP-QD-TEANATTYFTRLIESSL-GSVATKLNFFIHNLAQMKFLG--SDD RLTLSFAPRTHTLKSSGRISDVFLCRHEKVFHPNKGYIYVVKVMRENAH-EAAYIQRTFE EFQELHNKLRLLFPSSLLPSFPSRFVIGRSRGEAGAERRREELNGYIWHLVHAAPEVAEC D-----------LVYTFFHPLPRDEKTAGSSLA----PK--SSEGTWA--RPVGRVGGEV KLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKKKTKVARKTCNPT YNEM--LVYDGIPKGDLQQRELQLSVLSEQGFWENV-LLGEVHIRLRELDLAQEKTGWFA LGSRSPE-- >X_tropicalis_ENSXETP00000034942 ----------MAYISSSNGFRQSVSSSAGATRPKE-VDKEEALQMEAEALAKLRKD-RRQ G-----------------------------------------RGQGGA---FMQG--RQK PP-ASG------------------RQEPDLMVFPESDAKKKNNAETFLGIDVEKLTDAEM ERLLLDDHFDQRKPLAISQAPVANPRASPQFYGQP-----------SFQRSQWAPGIQGT ------------GTVNL-------LPSFSA-SYPKCAHPFQNGYNASVPAIRRHDPVYLS LPT-G---SQYVSYQMAARAPFQP-RGNL------------------------------- ------------------SSYSNTVSPDMAKLFDKIA-----STSEFVKNGRSSAEADAA KSESTSPTVQGAD--------DADSIN--------------------------------- ---------------KFDWLDLDPLSKPK-VDSTDSSNHAQ------------GSGASPS DSKVKD-------------------PWDAVLLEEKPIK---YSSPEKKLNG--------- KP-SGATVTRSLSLNIRPTHLQ-------------------------------------- -----QKW-----------DQPQQ---KD-SGT-RVPAEN-------SLLKELEADDEEV AAFCQEVAK---LRKKFPSSRLQT---NPGFVLSPVMLQRN-LSAEIA-NVKVSI----- -----------------------EIEGFQQPVTFTCDVSSPVELIIMQALCWVHDDLSQ- ------------VD-IESYILKVCGQEEVLQN-K-HCLGS-HE--YI-QLC-RKWDT-EI RLQLLC--HGTV--SRD-----LARTAEDDASPVDLNKHLAVVDRPFKEPIT-RQSIEEL LDTYHEQVSVCLKHESN-------------------PYRLVEQLIKVVRSICKTVGS-VE TPAITESV--KKLRRAVNLPRSRSIEV-----------TIPVLVGGRAHPPIRMK-SAR- -------------------QSDSPLQETLALLTTDLHNLLQLHF-SSG-NSAAT------ -APPGG----RPLKE--------ARTSPDH-LQFTIFAAHG---------IPTGWVSCFE KYYLVCSLIHNGKDKFK-PVQS----KKVGTYK-SFFYLV-KW-DELII-F-PIQISQLP LESILQLTLYGILN----PNSGG-----------SPDANKQR-------KGPEMLGRVSL PLFTFR-R----------------MLIGGTKLLHLWTSFHT-G------PAPAGTTRKTN QMQR------IVLQ-----VDFPLPAF---DIVYIPPHP--------TKSC--------- ------------------------------------------------------------ -----A-WQSIESL---DKDA----KSRLLSLL----AKESAFGLSKEEKAFLWEK-RYY C-LEHRNSLPKI-LASAPNWDVAYLS---DIY---ALIHEW-----PPMTAVSALELLDS RFSDQEVRTVAVKWVEEG-LSDDELVDFLPQFVQALKYELYLDNSLVRFLLTRALG--NI RITHYLYWLLKDSL-N------D-----------------------PYFGTRYERILGAL LSVCGKGLREELEKQTRLTQLLGVVAEKVRQA--S---GSARQ----------------- VVLQEGMERVQL-LF----RKT-KCRLPLSPSLVAKEL-N-IKACSFFSSNAVPLKVTMV NADPL-----GEEI----NSMF--KVGE--DL-RQDMLALQMIKIMDKLWLQEGLDLRMV LFKCLSTGRDR---GMVELVLSADTLRKIQV---EYGVT-GSFKDKPL--AEWLRKYNPS EE-------------------------DYAKASENFIY-SCAGCCVATYVLGICDRHNDN IMLRTTGHMFHIDFGKFLGHAQMFGSFK--RDRAPFVLTSDMAYVINGG--EK----PTR RFQLFV---------------DLCCQAYNLLRKHTSLFLNLLSLMLPS-GLPELTGIQDL KYVH--DA-LQP-QA-TDTEATIFFTRLIESSL-GSVATKFNFFIHNLAQ-RFAGLPSND EAILSFTPKTYSLKQDGRIKEATIFTYHKRYNPDKYYIYVVRVVREGQD-NSAFIFRTFD EFQELHNKLSILFPLWKLPGFPSKVVLGRTHIKEVAAKRKVELNSYIQSLMGSTPEVAEC D-----------LIYTFFHPLLRDDKSEGSDAI----VAPLGRDEPPLS-PTSGRIEGEI KLSISYRNGTLFIMVMHIKNLV-IEDNTDPNPYVKTYLLPDPHKTSKRKTKVSRKTCNPT FNEM--LVYSGYNKETLRQRELQLSVLSAESLRENF-FLGGVTLPLKDFNLNQETVKWYK LTEVPY--L >M_domestica_ENSMODP00000001932 -----------MSSTQGDGEHWKSLESVGISRKE--LAMAEALQMEYDALSRLRHD-KEE N-----------------------------------------RKVKQ------------- ------------------------NTDSSLISWDGPVLDFYGKP-AGGR----N--DLKL LRGLSGSDPTLNY--NSFSPQDGAPNHSTSEG------P------Q-PGPDPWLKGPLSG ------------DYLYIFDGSDGGVSPPPGQEDRN--SSPKKLSPPPIPP---------- ------------RVSIWDAPPQPP-SKTY------------------------------- ------------------TLSPKPSEPNDINTFSSNQ-----Q-PPSKLLGRRILEEEE- PGGRGQGNLLGSV----------------------------------------------- --------------------DYDGINDAI------------------------------T RLNLKS-------------------TYDTELLQDPKRG---WKEGQGLLGF--------G KDTPGKPVARSKTMPPQVPPRT-------------------------------------- -----YAYRYANRKNVAPSKNRRISVDPVSSRPRSTANGY-------ELFEVSEERDEEV AAFCHMLDI---LRSGSDIQDYSL----TGYVWSAVNLSPE-HLGAGV-SLKVTV----- -----------------------VCEGLREPLTFTCDCSSTVDLLIYQTLCYTHDELRG- ------------VD-VGDFVLKLCGLEEFLQN-K-HPLGS-HE--YI-QQC-RKFDT-DI RLQLMK--RKDV--RTD-----LARTMNDDQSPSTLNHYIHLQERPVKQTIS-RQALSLL FDTFHNEVDAFLLAEGD-------------------FPLKADRVVQSVKAICNALAD-VE SPEITNAL--NQLPP---CPSRMQPKI------------------------QKDP-SVL- A-------------------VRENREKVVEALTAAILDLVELYCNTFN-ADFQT------ -VVSGN-QKHELVQE--------ACLLSGP-LAFTVYATHR---------IPITWATSYE DFYLSCSLSHGGKELCS-PLQT----RKAHFYK-YLFHLI-IW-DQQIC-F-PVQINRLP RETLLSATLYAVPI----PPPGS-----------SSEANKQR-------RVPEALGWVTT PLFNFR-Q----------------VLTCGRKLLGLWPATQD-N------PSARWSAPNFH QPDS------VILQ-----IDFPTSAF---DIKFTSPPG--------AEFS--------- ------------------------------------------------------------ -----P-QYEFRSL---GGED----QQRLKDIM----QKESLYWLTDADRKRVWEK-RYY C-HSEVSSLPLV-LASAPSWEWACLP---DIY---ALLKQW-----THMNHQDALGLLHA TFPDQEVRRMAVQWI-DS-ISDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVC--DL RVTHYFFWLLKDGL-K------D-----------------------SQFSIRYQYLLAAL LCCCGKGLREEFNRQCWLVNTLAKLAQQVREA--T---PSARQ----------------- GILRTGLEEVRK-FF----KINGSCRLPLSPSLLVKGI-V-PRDCSYFNSNAVPLKLSFQ NVDPL-----GENI----RVIF--KCGD--DL-RQDMLTLQMIRIMNKIWIQEGLDMRMV IFRCFSTGRGR---GMVEMIPNAETLRKIQV---EHGVT-GSFKDRPL--ADWLQKHNPG ED-------------------------EYEKAVENFIY-SCAGCCVATYVLGICDRHNDN IMLKTTGHMFHIDFGRFLGHAQMFGNIK--RDRAPFVFTSDMAYVINGG--DK----PSS RFHDFV---------------DLCCQAYNLIRKHTHLFLNLLGLMLSC-GIPELSDLEDL KYVY--DA-LRP-QD-TEANATTYFTRLIESSL-GSVATKLNFFIHNLAQMKFTG--SDD RLTLSFAPRTYTLKSSGRISDVFLCRHEKVFHPHKGYIYVVKVMRENAH-EAIYIQRTFE EFQELHNKLRLLFPSFHLPSFPSRFVIGRSRGEAVAERRKELLNSYIWHLIHFSPEVAEC D-----------LVYTFFHPLPRDDKAAGISPA----PK--SSDGTWA--RPVGKVGGEV KLSISYKNDKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARKTCNPT YNEM--LVYDGIPKGDLQQRDLQLSVLSEQGFWENI-LLGEVHIRLRELDLTQEKMGWFE LGSRSHG-- >G_gallus_ENSGALP00000000882 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SLANGY-------ELFEVSEERDEEV AAFCHMLDV---LRSSSSPQDYSL----TGFVWSAVNLSPE-HLGHGI-SLKVTV----- -----------------------LCDSLREPLTFTCDCSSTVDLLIYQTLCYTHDELHT- ------------VD-VEDFVLKLCGLEEFLQN-K-HALGS-HE--YILQLC-PPHSTEDL RAPRAP--ISSLLRGVS-----FVGSQGMTRAPSTLNHYIHLQERPIKQTIS-RQALSLL FDTFHNEVDTFLAAEGD-------------------FPLKAERVIQSVMAICNALAA-VE SQEITTAL--NQMPP---CPSRMQPKI------------------------QKYP-SPML GPPYGTQQGCRSGAAPRHPSPFSPAERIVESLTAAILDLVGLYCSTFN-ADFQT------ -AVQWS-REHGVVQE--------ARLLSCP-LSFTVYATHR---------IPITWAASYE DFYLSCSITHGGKELCS-PLHT----RKAHVYK-YLFHLI-IW-DQQIC-F-PVQVNRLP RETLLSVTLFAVPV----PPPGS-----------SSDTNKQR-------RVPEALGWVTT PLFNFR-Q----------------VLTCGRKLLGLWPATQD-N------SRARSSAPNFN QPDS------VILQ-----IDFPTSAF---DVKFVSPLA--------ADVS--------- ------------------------------------------------------------ -----P-KYEFGSL---GEED----QRRLREAM----QKKSLYWLTDADRKRLWEK-RYY C-HAAPGSLPML-LASAPSWEWACLP---DIY---ALLSQW-----TYMSHQDALGLLHA TFPDQEVRRTAVQWI-DS-ISDTELLDYLPQLVQALKYECYLDSPLVRFLMKRAIC--DL KITHYFFWLLKDGL-K------D-----------------------SQFSIRYQYLLAAL LCCCGKGLREEFDRQCLLVNTLARLAQQVRDA--A---PSARQ----------------- GILREGLEEVKQ-FF----KANGSCRLPLSPSLLVKGI-V-PRDCSYFNSNAVPLKLSFQ NVDPL-----GENI----RVIF--KCGD--DL-RQDMLTLQMIRIMNKIWVQEGLDMRMV IFRCFSTGRGR---GMVEMIPNAETLRKIQV---EHGVT-GSFKDRPL--ADWLQKHNPE ED-------------------------EYEKAVENFIY-SCAGCCVATYVLGICDRHNDN IMLKTTGHMFHIDFGRFLGHAQMFGNIK--RDRAPFVFTSDMAYVINGG--DK----PSS RFHDFV---------------DLCCQAYNLIRKHTHLFLNLLGLMLSC-GIPELSDLEDL KYVY--HA-LRP-QD-TDADATTYFTRLIESSL-GSVATKLNFFIHNLAQMKFTG--SDA RPTLSFAPRTHTIKTSGRICDVFLCRHERVFNPSKGYTYVVKVKRESPS-EVTFVQRTFE EFQELHNKLRLLFPSSLLPSFPSRFIIGRSRGEAVAERRKEELNGYIWHLIHAAPEVAEC D-----------LIYTFFHPLPRDEKAASTNPA----PK--PADTTWA--RPLGKVGGEV KLSISYKNNKLFIMVMHIRGLQPLQDGNDPDPYVKTYLMPDPQKTTKRKTKVARKTCNPT YNEM--LVYDGVPRGDLQQRELRLSVLSEEGFWENI-LLGEVGIRLRDLDLAQEKKGWFA LGSRGY--L >O_anatinus_ENSOANP00000021244 LPLRDALSGPAMSATQGNGEHWKSLESVGISRSE--LAMAEALQMEYDALTRLRHD-KEE S-----------------------------------------R-AKG------------- ------------------------RAEPPLISWDGPVLEYYAKPAAGGR----R--DVQL VRGLSGSDPTLNY--NSLSPQDLPPNRCSSRG----SRP------G-SDPQPWCKGALPG ------------DYLYIFGSSGGGLSLPLGPPELSDGDSPKKLSPPPLPP---------- ------------RGSIWAEAPQPQ-GKGS------------------------------- --------------------------PNDINTFSSSR-----P-PPGKLLGRQIHRGDG- -SGGGRGDLLGAM----------------------------------------------- --------------------DFDGINDAI------------------------------T RLNLKS-------------------TYDSELLRAPGRD---WKEGRGILSF--------A KDTPGKPVARSKTMPPQVPPRT-------------------------------------- -----YASRCANRKNSASNKNRRISADPIGSRPHSATNGY-------ELFEVSEERDEEV AAFCHMLDV---LGMGRE--------------WTGVGEEQS-AVG--A-FLGRSL----- -----------------------LQGLLAGKLDFT------------------------- -------------K-PGRPSDRRPQLYGALPN-V-STAGS-H-------LCPLKFSE-RG REELMADWQEAL--RGNWKWKWLVKTMPPPHPTVGWPHPIVSDAVP-------------- ---------------GD-------------------FSPKAERVVQSVMAICNALAA-VE SPEITSAL--NQLPP---CPSRLQPQI------------------------QKDL-SGL- -------------------TVRENREKVVESLTAAILELVELYCNTFN-ADFQT------ -TAHDS-RKHALVQE--------ACFLPRP-LSFTVYAAHR---------IPITWATSYE DFYLSCSLSHGGKELCR-PLQT----RKAHVYK-YLFHLI-VW-DQQIC-F-PIQVNRLP RETLLSATLYAVPI----PPPGS-----------SSEANKQR-------RVPEALGWVTT PLFNFR-Q----------------VLTCGRKLLGLWPATQD-N------PSARWSAPNFH QPDS------VILQ-----IDFPTSTF---DVKFTSPQG--------AEFS--------- ------------------------------------------------------------ -----P-CYEFGSL---GEED----QRKLRDIM----QKESLYWLTDADRKRVWEK-RYY C-HAEVSSLPLV-LASAPSWEWACLP---DIY---ALLKQW-----THMNHQDALGLLHA TFPDQEVRRMAVQWI-DS-ISDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVC--DL RITHYFFWLLKDGL-K------D-----------------------SQFSIRYQYLLAAL LCCCGKGLREEFNRQCWLVNTLAKLAQQVREA--A---PSARQ----------------- AILRSGLEDVKQ-FF----ILNGSCRLPLSPSLLVKGI-V-PRDCSHFNSNAVPLKLSFQ NVDPL-----GENI----RVIF--KCGD--DL-RQDMLTLQMIRIMNKIWVQEGLDMRMV IFRCFSTGRGR---GMVEMIPNAETLRKIQV---EHGVT-GSFKDRPL--ADWLQKHNPG ED-------------------------EYEKAVENFIY-SCAGCCVATYVLGICDRHNDN IMLKTTGHMFHIDFGRFLGHAQMFGNIKRPRDRAPFVFTSDMAYVINGG--DK----PSS RFHDFV---------------DLCCQAYNLIRKHTHLFLNLLGLMLSC-GIPELSDLEDL KYVY--DA-LRP-QD-SEANATTYFTRLIESSL-GSVATKLNFFIHNLSQMKFTG--SDD RLTLSFAPRTHTLKGTGRISDVFLCRHEKVFHPNKGYIYVVRVQRENAR-EAFYIQRTFE EFQELHNKLRLVFPSSHLPSFPSRFVIGRSRGQAVAERRKEDLNGYIWHLIHAPSEVAEC D-----------LIYTFFHPLPRDEKAAGISPA----PK--SLDGTWA--RPVAKVGGEV KLSISYRNNKLFIMVMHIRGLQPLQEGNDPDPYVKIYLLPDPQKTTKKKTKVARKTCNPT YNEM--LVYDGIPKGDLQQRELRLSVLSEASFWEKT-LLGEVCICLRELDLAQEKKGWFA LGSRSHGTM >T_rubripes_ENSTRUP00000038296 ----------MAQISGGNGFKPDMHM------SKGVVGKEEALRMEEEALAKLQKE-KKT T-----------------------------------------VPGSSL---SVASLSKPQ LSKTSSAPPQ----------PSENRAEKDLIVF--PETRKPVDQDQLRDIDVDKLTNEEL EKLLLDENFGTRSSVSRPSS-LLGFNLSASYPGGH---V------SPFQSAQWGSVLSTP ------------SGSNLSTPTHQPTPMFPSTAFPK-PSSFQNGFAPAIPP-------YIA LPGQP---SPFMTF-----TPTQPAAAAM------------------------------- ------------------VYPQQAVDPQMAKLFDKIA-----STSEYLKNGKTSS-TEQE SSLAVPVSLAPNPSPQQPAGAESAGIS--------------------------------- ---------------CFDWLDLDPLTKQK-ADNEEPSHV--------------IVDGPLL EPAGVD-------------------PWDAVLETKDSS----GSSPLLKTKAC----SQHR RASTGAAVTRAHS---PTTSSS-------------------------------------- -----KQL-----------KAQIQVGGRCPEDGQMTLVKN-------SALEDVDAQNLEV VVFCEDVAATTSLRSKFPHSDLCT---NPGYVLSPVITQRD-AAGDASCSVKVSI----- -----------------------EISESQQPVTFTCDVSSPVDLLISQTLCWVHDDLDQ- ------------VD-FSSYLLKVCGREEVLQN-K-RSLGS-HE--YV-QNC-RKWEN-EI TLQLLS--QSTM--RRD-----LARTAEDDDAPIDLEKHLGQVDRPFKENVT-RQGLADY LEGYHSQVSICLQNENS-------------------QYKTVDRIVQTLKNLCCALDE-VE TQTVTEAI--KRLRHSANLPRTHSPK---------------------MASKSSRQ-SSN- -------------------GPTSPVEGSTALLTEAVYHLVKLYLRSFCNPSASF---RLA PPPAGEAVEDRNGRE--------ASGTTDH-LQFTLFAVHG---------IPASWVSSYE KYYLMCSLTHNGKNLFK-PIQS----QRVGTYK-NFFYHI-KW-DELIS-F-PVAVAILP LESILTLTLFGILN----QNAGG-----------SPDSNKQR-------KAPEQLGKASM PLFDFR-G----------------ILAKGSRLMCLWSCDQA-A-T--NSNSSSATSRRRL PTER------IVVQ-----VDFPQSAV---DVLYVGPQE--------AGSP--------- ------------------------------------------------------------ -----E-SHRYEEL---DPDL----QRKLETVC----SRASNFGLKRADYQMLWDQ-RIH CWKKHPNSLPKV-LASVPSWDWGSIA---HVH---SLLHHW-----PSLPPFTALEMLDS KFSDTEVRRVAVSWI-EQ-SSDDELADYLPQLVQALKFECHLKNALVTFLLSRAQQ--NI NIAHYLYWLLKDAV-Q------D-----------------------PAWGGRYERVLGAL LCLCGAKLRAEFDKQTQLVDLLGRVAERVRQA--G---GSVRQ----------------- AALVEGLESVQN-FF----QRN-SCRLPLSPSLVAKEL-N-LKACSFFNSNAVPLKLALV NADPL-----GEEI----NVMF--KVGE--DL-RQDMLALQMIRVMDRIWLQEGLDLRMV NFKCISTGKHK---GMVELVPSSDTLRKIQV---EYGVT-GSFKDKPL--AEWLRKYNPA ED-------------------------EYDKASENFIY-SCAGCCVATYVLGICDRHNDN IMLRSTGHMFHIDFGKFLGHAQMFGSFK--RDRAPFVLTSDMAYVINGG--ER----PTS RFQLFV---------------DLCCQSYNLMRKHSGLFLNLLSLMTSS-GLPELSGSQDL KYVF--DA-LQP-HS-TDADATIFFTRLIESSL-GSVATKFNFFIHNLAQLRFSGLPAND EPILSFSPKTYTLKQDGRILHASIFSFQKRYNPDKHYTYVVRLQREGHT-EPQFLFRTFD DFLELHNKLSILFPLWKLPSFPNKMVLGRTHVKEVATKRKMELNNYVHNLLRSSSEVTEC D-----------LIYTFYHPIARDDKTEGLESP----PK--PE-EPPVS-PTSGRVEGEV KLSISYRNSTLFIMVMHIRDLV-SEDGTDPNPYVKTYLLPDPHKTSKRKTKISRRTRNPT FNEM--LVYSGYSKETLGLRELQLSILSAESLRENF-FLGGITLRLKDFDLSKETVKWYK LTAVPY--F >O_latipes_ENSORLP00000013515 DTLLTLSQLAAQTQKESNEMGWGGLEALGLSQRE--LVLAEALQMEYDALSRLKQDKSGS S----------------------------------------------------------- ----------TDQSGSPSPSQTLSKTPNPFIEYPQPSPSQPVLDPAGGS----------L PRELSGSNTSLNQPGGSQSPQYFPSMVSPISGGFDKDSPYILNPEISKSSD--------- ------------------LSGCSYRDFVGSGFLSKGFVAPPDDIPPAIPP---------- ------------------RNPIPPSSGSGNPF---------------------------- ------------------LPPRRSTSPRDVNLFMPDV------------DQPKVTSEDL- ------------------------------------------------------------ --------------------RFDLTNDSL------------------------------- -----------------------------SRLNETRPGLRAHRNIRGQ------------ ---FGKPVARSQTLPPQVPPRT-------------------------------------- --------------YVSDKNQRRVSAEPVSMGSRASGFSY-------ELFQVSEERDEEV AAFCHMLDV---LRSAYPHSDRSK---NAGFVWSPSVGHDELHQALGV-SVKVTI----- -----------------------ISEHFREPLTFTCDGSTTVDLLIYQTLCYAQDDLDH- ------------LN-VDDYLLKVCGQEEFLPN-S-QSLAG-LE--IV-QQC-LKFDW-DI RLFLTK--RSGV--NTE-----LARTKEDDDTASTMNHSILLQERPIKQTVT-REALTLL LDTFQNEAETFLLSEGE-------------------LPLHVERLVQSVKALCSSLAA-VE TPEVTAAL--NQLPA---CPCRLQPKV------------------------LKDA-SVL- -------------------AVRQNREKVVEKLTATILDLVELYCSTFN-ANFHT------ -TAQSR-GCTAPVQE--------AGLVTNV-LSFNVYAAHR---------IPITWAASYE GFFLSCSLTHGGAELCA-PQNT----SKQAVSK-YLFHLV-VW-DQRVC-F-PVQINQLP RESQLTVTLYATPL----PPPGG-----------AEEKGKQR-------RSIEALGWVTM PLFNFR-H----------------VLTCGRKLLGLWPSTPGRS------GNARTSSPNFS QPDS------VILQ-----VDFPTSSF---EVCFSTPAP--------ADFC--------- ------------------------------------------------------------ -----P-QYEFKKL---DTIS----QMQLQDVL----HKKAFFWLTTDNKRLLWEK-KAF C-QQESAALPLI-LASAPCWQWACLP---EIY---ALLRQW-----ACLSHMDALGLLHA SFPDQELRRTAVQWM-DS-ISDPELLDFLPQLVQAVKYECYLDSSLVRFLLRRAIG--DV RIAHYLFWLLKDNL-Q------D-----------------------SQFSARYQHLLAAL LCCVGRSLREQFDRQCWLVSILTKVAQKVRDA--T---ASSRQQ---------------- GVLREALEEVKK-FF----LLNSSCRLPLNPAMVATGI-K-IQSCSFYNSNAVPLKLSFQ NLDPH-----GDNV----NVIF--KSGD--DL-RQDMLTLQIIRIMNKIWIQEGLDMKMV IFKCFSTGRGR---GMVEMIPQADTLRKIQV---EHGVT-GSFKDRTL--ADWLQKHNPT EE-------------------------QYDKAVENFIY-SCAGCCVATYILGICDRHNDN IMLKTSGHMFHIDFGKFLGHAQMFGNIK--RDRAPFVFTSDMAFVINGG--DK----PSS RFHDFV---------------DLCCEAYNLIRKHAHLFLNLLGLMLSC-GIPELSDLDDL KYVY--DA-LRP-HE-SEADATMYFTRLIESSL-GSVATKLNFFIHNLSQMKFAS--SEE CPTLSFAPRVHTAKSDGVIRGLYICSHIRTSNTSKGYAYVVKVERDGQ--EVQLVQRTFE EFYELHCKLRLVFPSSKLPSFPSRFVIGRSRSEATADRRKDELNGYVWHLIHAAPEVAQC D-----------LVYTFFHPLPRDERAGTTS------SK--PAEIIWS--PASGKELGEV KLSISFKNEKLFIMVMHIRRLQPLQDGTDPDPYVKLYLLPDPQKTSKRKTKAARRTCNPT YNEM--LVYDRIPRGDLEQRTIHLRVLSDGAFWENT-LLGETFIPLNRVVPGQHWVDWHR LGGAGSDSA >A_carolinensis_ENSACAP00000000044 ----------MAQISGNNELRPCSSPSLGTAKAKE-VDKEEALQMEAEALAKMQKE-RVV P-----------------------------------------GNRQSI---DTLSKSWPN VQ-SCR------------------KQDHDLMVFPESDAKKKM-NDKLNTVDIEKLTRAEL EKLLLEENLESSKPTTLPATPGLSPSFSSQFYANP-----------TIQRGPWTPGLLGP ------------AACTV-------PSNYAPPSFSKQVGIFQNGFHPGLSTYQSTKPIYLS LPE-G---SQYISYTLPSTTTFHT-QQSL------------------------------- ------------------PIFHPTLTPEMAKVFDKIA-----STSEFQKNGRSSSDLEVT GAKSTI-NLPVPE--------SSNDIS--------------------------------- ---------------KFDWLDLDPLSKPK-GDSMEILYNAE------------DGGKVTC NTVVED-------------------PWDAVLLEEKSPG---KCHHERKLSG--------- KSTSGATVTRSQSLNIRTAQLA-------------------------------------- -----KLQ-----------GQTSQ---TD-CGTTSLPTGN-------KLLKNVEGQNQEQ AAFCEAIGK---LRTKFPHKNHDT---NPGFVLSPVMLQRN-ISGENS-SIKISI----- -----------------------EIEGFQQPVTFTCDASSPVELIIMQALCWVHDDLND- ------------VD-IGSYILKVCGQEEVLQN-K-HSVGS-HE--YI-QNC-RKWDS-EI KLQLLT--YNVI--CRD-----LARTADDDGTQIDLIKHLSNVEKLFRESIQ-SHSLEEL LEAYHNQVAIILKKE-K-------------------QLKAVDPVIKAVRKICCTLDG-VE TPAITMAV--KKLRRAVNLPRNKSPEV-------------ISSII-SLYKANGTT-GSL- -------------------QTENPLQVSLDQLTSAVYALLELHLNSCN-SCSLN------ -ALETE----RSTKG--------AWTATEH-LQFTVFAAHG---------ILSGWVSVYE KYYLVCSLTHNGKDLFK-PVQS----KKVGTYK-NFFYLI-KW-DELII-F-PIQISQLP LESILCLTLFGILN----QNSGS-----------SPDSNKQR-------KGPEMLGQVSF PLFDFR-R----------------ILASGTKLLHVWTPS-T-S------LVFGVAHKKGN LMER------IVLQ-----VDFPSLPF---DIIYKTPEA--------ASGS--------- ------------------------------------------------------------ -----T-CNSIETL---EKDS----RERLITIL----SKQGTVGLSRKDKAFLWEK-RHY C-HTDVNSLPKV-LASAPNWDLTTLP---EIY---LLLQQW-----PPLPPLTALALLDS NFTDQEVRTKAVKWI-EA-ISDDELADILPQFVQALKYETYLDNSLVRFLLARALG--NI RIAHYLYWLLKDTL-H------D-----------------------IKHGVMYEHILGAF LSVCGKRLREDLEKQTRLVQILGMVAEKVKQT--N---GSARQ----------------- VVLQSGMERVQS-FF----LKN-KCRLPLSPSLVAKEL-N-VKACSYFSSNAVPLKIALV NSDPL-----GEEI----NVMF--KVGE--DL-RQDMLALQMIKIMDKIWLQEGLDLRMV LFKCLSTGKDR---GMVELVPAADTLRKIQV---ENGVT-GSFKDKPL--AEWLRKYNPT EE-------------------------EYEKASENFIY-SCAGCCVATYVLGICDRHNDN IMLRSTGHMFHIDFGKFLGHAQMFGSFK--RDRAPFVLTSDMAYVINGG--EK----PTI RFQLFV---------------DLCCQAYNLIRKQADIFLSLLSLMLSS-GLPELNGVQDL KYVQ--DA-LQS-QT-TDAEATILFTRLIESSL-GSVATKFNFFIHNLAQLRFSGLPSND EPILSFSPKTYSLKQDGRIKEASVFTYHKRYNPDKHYIYVVRILREGQS-EPTFIFRTFD EFQEFHNKLGILFPLWKLPGFPNKMVLGRTHIKDVAARRKVELNSYMQSLMNASTDVSEC D-----------LVYTFFHPLLRDEKAEGIDGI----AK-----SLPSS-PVSGKVGGEV KLSISYRNSTLFIMVMHIKDLV-TDDGADPNPYVKTYLLPDIHKTSKRKTKISRKTRNPT FNEM--LVYSGYNKETLKQRELQLSVLSAESLRENF-FLGGVTLSLKDFNLNKETINWHR LAAVPY--L >G_aculeatus_ENSGACP00000008939 ----------MAQISSGNGFKVVVPQ------PKGVVGKEEALRMEEEALAKLQKG-KRP T-----------------------------------------LSASAPVPSSAASLSSST LSKSTSSAPQ--------PLPATNRPEKDLIVF--PETRKQAEQVKFRDIDVDKLTNEEL EKLLLDENFGVNSKVSRPSS-LLGFNLSASYPGGHPGSS------SPFHSGQWTPVLSTP ------------ANSSLSTPSHQPSP-FPSAPFPK-PGAFLNGFAPAMPA-------YMA LTGTQ---SSFMTF-----SPIQP-AAAM------------------------------- ------------------AFPQPAVDPEMAKLFDKIA-----STSEYLKNGKPGG-TDVD SSQAGQSSLAPNPPPQPPAVAESSTVG--------------------------------- ---------------RFDWLDLDPLTKHK-AENEEAPPAS-------------GPAAPSV PGVAGD-------------------PWDAVLETEGNSSGGGGSSPPEEVKAPPTGRSQLR RASTGAAVTRSHSLNVPGTSSQ-------------------------------------- -----HKA-----------NQQVRSQDPNYTTPRSPVGQN-------AALEEQDAQSLEV VAFCEDVAA---LRSRFPHGDMST---NPGFVLSPVITQRD-GGADNSCSVKVSI----- -----------------------EISESQQPVTFTCDVSSPVELLISQTLCWVHNDLDQ- ------------VD-FSSYLLKVCGQEEVLQN-K-HSLGS-HE--YV-QNC-RKWEN-EI TLQLLS--HSTM--RRD-----LARTAEDDNSLVDLEKHLGQVERPFKENVT-RQGLADY LEGYHNQVNICLQNEKT-------------------LYKTADRVVQTLKNLCCGLDE-VE TQAITEAV--KRLRHSVNLPRTHSPKT---------T---------IMTISTTSP-DWT- -------------------GHSSPLEESMALLTQAVYDLAKLYLRSFCAPSASFSSPSLP RPADGEGVVGQSSKE--------ASGTTEH-LQFTLFALHG---------IPANWVSSYE KYFLMCSLTHNGKNLFK-PVQS----KRVGTYK-SFFYHI-KW-DELIN-F-PIAVAVLP LESILSLTLFGVLY----QNASG-----------SPDSNKQR-------KAPELLGKVSM PLFDFR-R----------------VLAKGSRLLCLWTSAQG-A-------AGSAGGRSKV PTEK------IVLQ-----VDFPNSAL---DVLYVGPKE--------EPRL--------- ------------------------------------------------------------ -----D-LDALEEL---DPDL----QRDLEKIC----SRASNFGLKRADHQLLWDH-RLH CRKHHPSSLPKV-LASVPSWDWASMA---HIH---SLLHHW-----PPLPPVTALELLES KFADTEVRNVAVSWI-EK-SSDDELTDYLPQLVQALKFECHLKNGLVMFLLSRAQG--NI NIAHYLYWLLKDAV-Q------D-----------------------PAWGRRYERVLGAL LCLCGVKLRAELEKQTNLVTLLGAVAERVRQA--G---GSTRQ----------------- VALQEGLENVQN-FF----QRN-SCRLPLSPSLVAKEL-N-IKACSFFNSNAVPLKLALV NADPL-----GEEI----NVMF--KVGE--DL-RQDMLALQMIRIMDRIWLQEGLDLRIV NFKCISTGKDK---GMVELVPSSDTLRKIQV---EYGVT-GSFKDKPL--AEWLRKYNPA ED-------------------------EYEKASENFIY-SCAGCCVATYVLGICDRHNDN IMLRSTGHMFHIDFGKFLGHAQMFGSFK--RDRAPFVLTSDMAYVINGG--ER----PTS RFQLFV---------------DLCCQAYNLIRKHSGLFLNLLTLMTSS-GLPELAGSQDL KYVF--DA-LQP-HN-TDAEATIFFTRLIESSL-GSVATKFNFFIHNLAQLRFSGLPAND EPILSFSPKTYTLKQEGRILHASIFSFQKRYNPDKHYTYVVRLLRDGQN-EPQFVFRTFD EFQELHNKLSILFPLWKLPSFCNKMVLGRTHIKEVAAKRKLELNNYVHNLMRSSTEVTQC D-----------LVYTFFHPIARDEKTEGLEA------K--AP-EPPLS-PTSGRVEGEV KLSVSYRNSNLFIMVMHIRDLV-SEEGTDPNPYVKTYLLPDPHKTSKRKTKISRKTRNPT FNEM--LVYSGYSKETLGLRELQLSVLSAESLRENY-FLGGITLRLKDFDLSKETVKWYK LTAVPY--F >D_rerio_ENSDARP00000080566 ----------MAHISSGNGFKFDRPASPGVVRPKGIVGKEEALRMEVEAFDKIKRE-KRH T-----------------------------------------LPVTAS---SVNPLPNPT AQTSSS------------------RPEKDLIVFCESETQKKEQKDNFEDIDLENLTKEEL EKLLLDDSFGANK-MTRPSS-LLGCNLSASYPGGHAFNP---------SSFHWTP----- ------------------TPTHAQTPIFPSAPFAKPPCSFQNGFSPAMSPFIPP------ --------TPFLSF-----TPIQP-PAAL------------------------------- ------------------VYSQPAVTPEMAKLFDKIA-----STSEYLKNGRSSS-METE S--ASVKSLEPLPLPS-----EPPNIS--------------------------------- ---------------RFEWLDLDPLNKRKEVEVEETPAVS-------------SCPFIEE SGKAKD-------------------PWDAVLQDEHETVDNGSPTAEEKSKA-----TQPR RASTGAAVTKSQSLSISANSTN-------------------------------------- -----QST-----------GKQVN------KGSTNVLSKY-------SALQEKEAQNLEV VAFCEDISK---LRSKFPHDDLST---NPGYVLSPVITQRD-AGGDNGGSVKVSI----- -----------------------EISDSQQPVTFTCDVTSPVDLLIMQALCWVHDDLNQ- ------------VD-INSYVLKVCGQEEVLQN-K-HSLGS-HE--YV-QNC-RKWES-EI KLQLLF--LSTM--RRD-----LARTAEDDISPIDLEKYLGLVERPFKEAVT-REGLAEY LEGFHKQVNLCLQNENN-------------------QYKTVDNVVQSVKNLCCALDE-VE TPAITDAV--KRLKRSVNLPRTRSPESKMFFYCYMCACFIKHYAELQAGATSSGG-SAN- -------------------GYSSPVEESLAVLTDAVYELAKLYLQSFCPISPGF---MIE EHKEDE----RDSKE--------ASGTTEH-LQFTLFAVHG---------IPATWVSSFE KYYLMCALTHNNRNLFK-PVQS----KKVGTYK-SFFYHI-KW-DELIN-F-PISVSLLP LEAMLSLSLYGVLS----QNANN-----------SPDSNKQR-------KGPELLGKVSM PLFDFR-R-QVINSTSNTQELPLGVLSRGSKLLSLWTSPQA--------LQPGAAGKGRN PTEK------IILQVLSF-VDFPSPAV---DVLYVGPQE--------NGCP--------- ------------------------------------------------------------ -----N-PQSLDPL---DQDD----RSEIEKLC----ARASTFGLSRADRQLLWDQ-RYY C-REYEYSLPKI-LASAPSWDWGSMG---EIH---ALLHHW-----PALSPVSALELLES KFADTEVRKVAVSWI-QS-SSDDELADYLPQLVQAVKFECHLNNALVKFLLSRALG--NV NIAHYLYWLLRDAV-Q------D-----------------------PAFGQRYERILCVL LCLCGTGLRAELEKQTRLVQLLGALAEKVRQA--S---SSTRQ----------------- VVLLEGLERVQS-FF----QKN-SCRLPISPSLVAKEL-N-IKVCSFFNSNAVPLKIALV NADPL-----GDEI----NVMF--KVGE--DL-RQDMLALQMIRIMDRIWLQEGLDLRIV NFKCISTGKDK---GMVELVPSSETLRKIQV---EYGVT-GSFKDKPL--AEWLRKYNPA ED-------------------------EYEKASENFIY-TCAGCCVATYILGICDRHNDN IMLRSTGHMFHIDFGKFLGHAQMIGSFK--RDRAPFVLTSDMAYVINGG--ER----PTS RFQLFV---------------DLCSQAYNLIRKHSNLFLNLLSLMTQS-GLPELTGVQDL KYVY--DA-LQP-QT-TDAEATIFFTRLIESSL-GSVATKFNFFIHNLAQLRFSGLPSND EPILSFAPRTYTMKQDGKIRDASVFSFQKRYNPDKHYTYVIRILREGQS-EPQFVFRTFD EFQELHNKLTILFQLWKLPGFPSKMVLGRTHIKDVASKRKVELNSYVHNLMRSSTEVAQC D-----------LIYTFFHPIARDDKTEGVDTL----SK--TPDMPPVS-PTTGRVEGEV KLSVSYRNSTLFIMVMHIKDLM-SNDGADPNPYVKTYLLPDPHKTSKRKTKIARKTRNPT FNEM--LVYSGYSKETLKQRELQLSVLSAESLRENC-YLGGITLCLKDFDLSRETVKWYK LTTVPY--F >D_rerio_ENSDARP00000080539 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------Y-------ELFQVSEERDEEV AAFCHVLDL---LRSAYPCNDYSK---NSGFVWSPCVAQDELQQGLGV-SIKVTV----- -----------------------YSDHFREPLTFSCDGSSTIDLLIYQTLCYAHDDLDM- ------------ID-VDDYLLKICSQAEFLKN-T-QTLAS-FE--YI-QQC-LKFDW-DI RLILTK--RSSV--NME-----LARTTEDDDTPSTMNHSILLQERPIKQTVT-KEALTLL LDTFHNEAESFLLSEVE-------------------LPLHVERLVQSVKALCTSLAA-VE TPDITAAL--NQLPMSVSWPRKKTEKL--HLFFFAFLFSIHFFSLHSYAPTTFNS-HLF- -------------------KYSSIIVAIVEKLTAAILDLVELYCSTFN-ANFHT------ -MPHSS-RSTAPIQE--------AGMVTNV-LSFSVYAAHR---------VPITWAASYE NFFLSCSLTHGGVELCA-PQHT----SKQSVSK-YLFHLV-VW-DQRVC-F-PVQINQLP RESQLTVTLYATPL----PPPGG-----------AEEKSKQK-------RSIESLGWVTM PLFNFR-HSQIFLYTKNRRGLVVVVLTCGRKLLGLWPSTPG-S------GNARSSTPNFS QPDS------VILQILHIIVDFPTSSF---EVRFSTPAP--------AEFS--------- ------------------------------------------------------------ -----P-QYEFSHL---DQVS----QRQLHDVL----HKKSLFWLSPEDRRLLWEK-RYF C-HVEASRLPLV-LASAPSWEWACLP---DIY---ALLRQW-----GCMNHLDALGLLNA TFPDQECRRTAVQWM-DS-ISDPELLDFLPQLVQALKYECYLDSHLVRFLLRRAIG--DV RIAHYLFWLLKDTL-Q------D-----------------------SQFSVRYQYLLAAL LCCSGRGLREEFDRQCWLVNVLAKVAQRVREA--S---PSSRQ----------------- AILREGLDDVKQ-FF----SINSSCRLPLNPGLLVKGI-N-IQSCSYFNSNAVPLKLSFQ NQDHL-----GDNI----NVIF--KAGD--DL-RQDMLTLQIIRIMNKIWVQEGLDMRMV IFRCFSTGRGR---GMVEMIPSAETLRKIQV---EHGVT-GSFKDRPL--ADWLQKHNPT EE-------------------------EYEKAVENFIY-SCAGCCVATYILGICDRHNDN IMLKTSGHMFHIDFGKFLGHAQMFGNIK--RDRAPFVFTSDMAYVINGG--DK----PSS RFHDFV---------------DLCCEAYNRIRKHAHLFLNLLGLMLSS-GIPELSDVDDL KYVY--DA-LRP-HE-SEADATMHFTRLIESSL-GSVATKLNFFIHNLAQMKFAS--SEE RPVLSFAPRVYTMKTDGVIRSLFVCRHIKTYSPSKGYSYVVKVEREGQQGSPTLVQRTFE EFNELHSKLQLIFPSSKLPSFPSRFVIGRSRGEALADRRKDELNGYVWHLIHAAQEVAQC D-----------LIYTFFHPLPRDERAGSVGNVVNTLHK--PTDVSWA--PVPGAMAGEV KLSVLYKSDKLFIMVMHIRGLQPLQDGTDPDPYVKLYLLPDPQKTSKRKTKAARRTCNPT YNEM--LVYDKIPRGDLQQRTVHLRVLSEGAFWENT-LLGETIIHLKDLTPGHRWVDWHQ KCITTVPFH >B_taurus_ENSBTAP00000043907 ----------MAQISSNNGFKKCSSSPPESTRTRD-VDKEEALQMEAEALAKLQKD-RQV T-----------------------------------------DNQRGF---ELSSSTGQK AQ-VYN------------------KQDYDLMVFPESDTQKRA-----VDIDVEKLTQAEL EKLLLDDSFETRKTPILPVTPVLNPALSAQLYLRP-----------AVQRGQWPPGLSGP ------------SSYTL-------PSIYQS-TYSTKQTAFQNGFNPRMPTFASTEPIYLR LPG-Q---SPYFSYPLTPATPFHP-QGSL------------------------------- ------------------PIYRPVISPDMAKLFDKIA-----STSEFLKNGKARTDLEI- NSKTTISNLQVSP--------KSEDIS--------------------------------- ---------------KFDWLDLDPLSKPK-VDNVEVEDHEE--------------EKNVP DLLADD-------------------PWDAVLLEERSPA---SCHLDRKVNG--------- KSLSGATVTRSQSLNIRTTQPT-------------------------------------- -----KVQ-----------SQIYQ---KDPNGTSTLPTES-------SLLQEIEVQNEEV AAFCQSITK---LKTNFPYTNHCT---NRGYLLSPVTVQRN-ICGENA-SVKVSI----- -----------------------EIEGFQLPVTFTCDVSSTVEIIIMQALCWVHDDLNQ- ------------VD-VGSYVLKVCGQEEVLQN-N-HCLGS-HE--HI-QNC-RKWDT-EI KLQLLT--FSAM--CQN-----LARTAEDDETPVDLNKHLHQIEKPYKEVMT-RHPVEEL LDLYHNQVELALQIE-N-------------------QHRAVDQVIKAVRKICGALDG-VE TLAITESV--KKLKRAVNLPRSRSAEA-------------TSLSGGGDINRSSSR-GSL- -------------------NPENPFQVSMDQLTAAIYDLLRLHA-NSG-RGSVD------ -CAQSN----GNIKE--------AWTTTEQ-LQFTIFAAHG---------ISSNWVSNYE KYYLVCSLTYNGKDLFK-PIQS----KKVGTYK-NFFYLI-KW-DELII-F-PIQISQLP LESLLHLTLFGILN----QSSGS-----------SPDSNKQR-------KGPEALGKVSL PLFDFK-R----------------FLTCGTKLLYLWTSSHT-N------LIPGTVPKKGY VMER------IVLQ-----VDFPSPTF---DIIYTTPQV--------DRSI--------- ------------------------------------------------------------ -----IQQHNLETL---ESDV----KGRLLDIL----HRDSSLGLSKEDKAFLWEK-RYY C-LKHPNCLPKV-LASAPNWKWVNLA---KTY---SLLQQW-----PPLHPLTALELLDS KFADQEVRSLAVTWI-EA-ISDDELTDLLPQFVQALKYEIYLNSSLVHFLLSRALG--NI QIAHHLYWLLKDAL-H------D-----------------------AQFGARYEHVLGAL LSVGGKGLREELLKQTKLVQLLGGVAEKVRQA--S---GSARQ----------------- VILQRSMERVQS-FF----LRS-KCRLPLNPSLVAKRL-N-IKSCSFFSSNAVPLKVTMV NADPM-----GEEI----NVMF--KVGE--DL-RQDMLALQMIKIMDKIWLKEGLDLRMV IFKCLSTGRDRAK-GMVELVPASDTLRKIQV---EYGVT-GSFKDKPL--AEWLRKYNPS EE-------------------------EYEKASENFIY-SCAGCCVATYVLGICDRHNDK IMLRSTGHMFHIDFGKFLGHAQMFGSFK--RDRAPFVLTSDMAYVINGG--EK----PTI RFQLFV---------------DLCCQAYNLIRKQTNLFLNLLSLYLKI-DIINILKCCHV KYAR--PH-LYV-HAKKKKDPQIFFTRLIESSL-GSIATKFNFFIHNLAQLRFSGLPSND EPILSFSPKTYSFRQDGRIKEVSVFTYHKKYNPDKHYIYVVRILRDGQL-EPSFVFRTFD EFQELHNKLSIIFPLWKLPGFPNRMVLGRTHVKDVAAKRKIELNNYLQSLMSASMDVAEC D-----------LVCTFFHPLLRDEKAEGI-------AR--SADAGSFS-PAQGQIGGAV KLSLSYRNGTLFIMVMHIKDLV-TEDGADPNPYVKTYLLPDTHKTSKRKTKISRKTRNPT FNEM--LVYSGYSKESLRQRELQLSVLSAESLRENF-FLGGITLPLKDFNLSKETVKWYQ LTAATC--L >T_nigroviridis_ENSTNIP00000005672 ----------MAQISGGSGFKPDVPA------SKGVVGKEEALRMEEEALAKLQKE-KRS S-----------------------------------------ASPASP---SAASVSKPQ LSKSSSAPRR----------PSE-RAEKDLIVF--PETRRAVDRDQFRDIDLDKLSDQEL EKLLLDENFGAKSSVSRPSS-LLGFNLSASYPGGH---A------SPFQGAQWGPVLSTP ------------R-SGVSTPAHQPPPVFPS-AFSK-PSSFQNGFAPALPP-------YIA LSAQP---PPFVTF-----TPIQP-AAAM------------------------------- ------------------VYPQPAVDPQMAKLFHKIA-----STSEYLRNGRSSS-TEPD ASLGAPASLAPNPPPPQPVGAESAAQS--------------------------------- ---------------RFNWLDLDPLTKRK-AESEEVSRLEEREKAALRRDEEERAAGWFE EAAGEA-------------------GGDERIGGPRTS----SKTPRLR------------ -----PPISRSPL---STDQTG-------------------------------------- -----SPE-----------QHQLQ-------DAAKALLRN-------SALEEADAQNLEV VVFCEDVAA---LRSRFPHSQLST---NPGYVLSPVITQRD-AGGDASCSVKVSI----- -----------------------EISESQQPVTFTCDVSSPVELLISQTLCWVHDDLDQ- ------------VD-FSSYLLKVCGREEVLQN-K-RSLGS-HE--YV-QNC-RKWEN-EI SLQLLS--QSSM--RRD-----LARTAEDDHAPVDLEKHLEQVDRPFRENVT-RQGLADY LDGYHKQVNICLQNENS-------------------QYKTVERVVQTLKNLCCALDE-VE TQSITEAV--KRLRHAANVPRTHSPKV--GWDGWMCC---------RMASKSSGP-ASN- -------------------GQSSPVEESMAVLTEAVYHLVKLYLRSFCPPSASF---RSA LPPAGEAGEGRSIRE--------ASGTTDH-LQFTVYAVHG---------IPASWVSSYE KYYLTCSLTHNGKNLFK-PIQS----KKVGTYK-NFFYHI-KW-DELIS-F-PVAVAILP LEALLTLTLFGVLN----QNAGG-----------SPDSNKQR-------KAPEQLGKAST PLFDFR-G----------------LLAKGSRLMCLWSCDQA-A------------SRRRL PTER------VVLQ-----VDFPQPTL---DVLYVGPQS--------RG-P--------- ------------------------------------------------------------ -----R-GHRYEEL---DPDL----QRSLENIC----SRASNFGLKRADYQLLWDQ-RLH CWKKHPGSLPKV-LASVPSWDWASIA---HVH---SLLHHW-----PSLPPVTALEMLDS KFADTEVRRVAVSWI-EQ-SSDDELADYLPQLVQALKFECHLKNALVVFLLSRAQR--SI SIAHHLYWLLKDAV-Q------D-----------------------PAWGGRYERVLGAL LCLCGAKLRAEFYKQTQLVALLARVAERVRQA--G---GSVRR----------------- AALMDGLESVQN-FF----QRD-SCRLPLSPSLVAKEL-N-LKACSFFNSNAVPLKLALV NADPL-----GEEI----NVMF--KVGE--DL-RQDMLALQMIRVMDRIWLQEGLDLRMV NFKCISTGKHR---GMVELVPSSDTLRKIQV---EYGVT-GSFKDKPL--AEWLRKYNPA ED-------------------------EYDKASENFIY-SCAGCCVATYVLGICDRHNDN IMLRSSGHMFHIDFGKFLGHAQMFGSFK--RDRAPFVLTSDMAYVINGG--ER----PTS RFQLFV---------------DLCCQAYNLMRKHSGLFLSLLALMTSS-GLPELSGSQDL KYVF--DA-LQP-HS-TDADATVFFTRLIESSL-GSVATKFNFFIHNLAQLRFSGLPAND EPILSFSPKTYTLKQDGRLLHAAIFSFQKRYNPDKHYTYVVRLQREGHA-EPQFIFRTFD DFLELHNKLSILFPLWKLPSFPNKMVLGRTHVKEVAAKRKLELNSYVHNLLRSASEVTEC D-----------LIYTFFHPVARDDKTEGLGSP----PK--PEGGTPAD-PTSGRVEGEV KLSISYRNSTLFIMVMHIRDLV-SEDGTDPNPYVKTYLLPDPLKTTKRKTKISRRTRNPT FNEM--LVYSGHSREALGLRELQLSVLSAESLRENF-FLGGVTLRLRDFDLSKETVKWYK LTAVPY--F >A_aegypti_AAEL000386-PA ----------MASR-NEVEMEKQFLAE---------LEKAKALSLETFELEKIR-QQRYS QPESLN--KSDTRTLAEYKTYLERRAKLHQG--APSGSNDGPKSASNVNLP----NVSRF NSEPRTDAQG--------SQLPRGKGEADLISFIAPPAPPNPQDEAHNN--LKELVDQMH RLN--TQNP---YEQSFKTQRSLSMSSATSYGGYSPAYL------QQQVVQNCNPAAM-- ------------QLVPYNQQTAKPKPLTPDELNRLYNM-PTYGTMPAG-------PPPQA GFIAQ---PQYAPVNYPQTSTTFPLQQVHPVSVPTNFIPQPVAPVAPAAASGFIPQTP-- -------------QTIYATSTVPVANPNSALVHVPKA-----VNPKLTLNTRSASQPQQP FPPAIPGPSNSNPFSRNSLGSNPTNNRTTNSNHNVTSGSSGNNGSSSNGDVVLRPKSDPS KLGG-----------GDNLIDFGGFEDNSRVSVLEAFDPLLCGNRTSSGDGSDDDKDDTA STYYEDYDPFDYIYSG--GTQYSDPVYEAV---NRSDK--TPLSPNSSGSG--------- --PPPIGWNVSSAYGFGEPEFQ-----------------EGEPPPLPPRNSDL---YHPM IGGGGGLGPAITSSNYEIMQ---TPAA---QRRSVPTKLY-------ENVVVRKSYDKEL IAFYNMVKQ---LRAQFRYDDLKT---NVGHVVASEFNNHY---PDGT-SIKLLVH---- -----PSLDCFTS---FDSQNKGQIDGYGPPIPFTCDITTSVEHVIAQVFCALEGQIMN- ------------S--VGDYVLKSIGMQEILST-S-SRLNQ-LQ--CV-HNS-IKLEH-DV QLGLVP-KSPRI--MRT-----IARTAQDDHRDAEIRLE-HILPKEATSAVG-YDQLMIL LETLEAEIDKLQSTADD---------------HSPHSILSCSGVTQAVKAICAMLGK-ID TLEITKAV--DDLKTCCDSGQTIYSYNDS----SDYNNGSLSIVSESGDYAEVKL-RPR- -------------------TISQQIRYRCNEVRNAIQSLLEIYSHAFR-VTFMV------ -NVPEW---NTNPIP--------INMISQS-IMVNVMCLHR---------IPELW--RHD EYNLGVQIYHGARYISE-PLVT----YCSNERT-GTYPRL-TF-NSWLT-F-RNAVVTLP RESRLIFVLYGVTR----EPVE-GDKQDGSSNA-DQNTQEGR-------VTKIELGWSAI QFFDFE-R----------------KMIQGSYLLPLWPPTAE--------KYFGPAPAKGT HPMGDA---YPILG-----IEIPSYGG---SVVFPEPIK--------NMPP--------- ------------------------------------------------------------ -----AVKLDFNSL---DRNL----QQELIDTA----EQGYS-ADKLEKREVLWEK-RHY L-HSLPHALPKV-LHAAHSWDYACLE---DLH---AFLKSW-----PALTPVQALELLLP RYPDLEVRRQAVEWI-SH-MPNDEFVDYLPQLLQALKHDTYEASPLAQLLLSKSLE--SP RIAHHLYWLLLHSL-P------GDAPQNMIEMG--QY--DETLVIQARYHRRNQLMLRAL MATCGEKLTARFLSQNMMCKKLGEVAQSVKMT--K---ESQRL----------------- QILKQGLESVNQ-ML----IDN-PTVLPLGPGNEVTGV-V-VRSCNYFNSNTLPLKVNFM GPD-------KVIV----PAIF--KSGD--DL-QQDMLTIQMVRIMDKLWLREGLDLKMV TFNCVPTSYKK---GMIEMVSDSETLRKIQV---EWGLT-GSFKDKSI--AEWLAKQNPS QL-------------------------EYQRAVENFTR-SCAGYSVATYILGICDRHNDN IMLKTSGHLFHIDFGKFLGDAQMFGNFK--RDRTPFVLTSDMAYVINGG--DK----PSA KFHKFV---------------DLCCTAFNIVRKHGDLILHMFALMTTS-GIPGVT-VEAV NYVR--NA-LLP-GQ-SNPEAAASFAKMIGISL-KSWFTQFNFFLHNIAQMKFSA-ENDD GELLSFVPRVYTMAQDGRLKSVTVHGFQKRYDLEKYYTYILKVTRQNQP-DPAYLFRSYK EFCEFHQKLCIHFPLAKLHSLPSGIHVGRSNVKTVAERRLPEIRQFLISLFNSADEIAHS D-----------LVYTFFHPLLRDQQEADIHA-----TKVKGNRAIADE-YQ--QLRGEI KFSLQYHRDALIVMIQHARSLPSTPNNPEPNTYVKVYLRPDQSKATKRKTKVVRKNCNPS FMET--LEYR-LPLEFIQKKTLEVTVWSHDSLQENA-FLGGHRLALAELDLRYEINEWFP LGYLPR--S >B_taurus_ENSBTAP00000027780 -------------------MELENHEQPVVLREDNCRRRRRMKPRST---AASMSSME-- ------------------------------------------------------------ ---------------------------LIPIEFVLPT-SQRNT-KTPETALLHVAGHGNV EQMK-AQVWLRVLETSVA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------ADFYHRLGPDHFLLLYQKK----GQWYEIYDKYQVVQTLDCL HYWK--VLHRSPG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QIHLVQRH----SPSEET----LAFQRQLTALIGY-------DVTDVSNVHDDEL EFTRRRLVT---PRMAEVAGRD----------PKLYAMHPW--VTSKP--LPEYLL-KKI TN---NCIFII-------------IHRSTTSQTIKVSADDTPGTILQSFFTKMAKKKSL- MDIPE-------SQNEQDFVLRVCGRDEYLVG-E-TPIKN-FQ--WV-RQC-LKNGE-EI HLVLDT--PPDP--ALD-----EVRK--EEWP---------------------------L VD----DCTGVTGYHEQ-----------------------------------------LT IHG--KDH---------------------------------------------------- ------------------------------------------------------------ ----ES----VFTVS--------LWDCDRK-FRVKIRGIDIPV-------LPRN---ADL TVFVEANIQYGQQVLCQ-R-RT----SPKPFTE-----EV-LW-NVWLE-F-SIKIKDLP KGALLNLQIYCGKA-PALSGKAS---------AETP--SPES-R-----GKAQLLYYVNL LLIDHR-F----------------LLRHGEYVLHMWQLSGKGE-D--QGSFNADKLTSAT NPDKEN---SMSIS-----ILLDNYCH---PIALPKHQP--------TPD---------- ------------------------------------------------------------ -----PEGDRVRAEM--PNQL----RKQLEAII----ATDPLNPLTAEDKELLWHF-RYE SL-KDPKAYPKL-FSSVKWGQQEIVA---KTY---QLLARREVWDQSALDVGLTMQLLDC NFSDENVRAIAVQKL-ES-LEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLR--NK RIGHFLFWFLRSEIAQ------S-----------------------RHYQQRFAVILEAY LRGCGTAMLRDFTQQVQVIDMLQKVTIDIKSL--S---AEKYDVS--------SQVI--- FQLKQKLEILQ--NL----NLPQSFRVPYDPGLKAGAL-V-IEKCKVMASKKKPLWLEFK CADPTAL--SNETI----GIIF--KHGD--DL-RQDMLILQILRIMESIWETESLDLCLL PYGCISTGDKI---G--------------------------------------------- ------------------------------------------------------------ ---------------------------N--HQHEP----------------GK------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >M_musculus_ENSMUSP00000084939 -------------------MAYSWQTEPNRTEPQEDGSDTQQFHHTNQHLSSSQVR---- ------------------------------------------------------------ -------------------------------------------------LGFDQLVEEIN NKTPLSESEKEEDTYFVPDAPNLGSKWPSIYETHP------------------------- ------------------RYFSEFTSQSPDSSQLRFGKLSAIGFNPAVLP---------- ----T---HQLIHEGASWRNPSGKYHGIE------------------------------- ------------------YPRFDALPPSSTGQGECNP-----QGQSGTKHHNYCGEHEGN LPHHHSSYSIDSI----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PNREKRRSGDVNLVEPSLE-------------------------------------- -----FSK---------DSFLPRTSENVSVESTEPIGCPI-------EIVEVPQGSNKNL ASFCNKVKK---IRESYHASDINS---NSGKIWAITTAYPS-RLFADT-KFRVKI----- -----------------------SIDNSAQLLLLMPHANYLVKDLIAEILLLCANE--P- ------------LS-PKEYLLSVCGSEEFLQM-D-HSLGG-HK--IF-Q----KNKS-VI QLHLQK--NRDT--PGK-----LSRKSEDDHSPFHLNQLL---EFTHIWKIS-RHFSLCI LRSQYL-FSQLRLFPVM---VERRSLTRSAGC-FNTERPLSNVFLKTL--ITYITHCNIQ KDFLLDSIDFQDTCI---AFSSQKKNF-------------------------HQN-SET- -------------------SKKGFIERVTAELSRSIYQLIDVYCSTFC-TDFQP------ -VHTPG----GVSRV--------HAGLQSH-LSFTVCSLHN---------VPETWAHSYK AFSFSCWLTYAGKKLCQ-VKSC----RPLPVTK-SFSLLV-NW-NEIIN-F-PLEIKSLP RESMLIIKLFGI--------------------------DSAT-------HSTNLLAWTCL PLFPRQ------------------ESVLGSRLFSVTLQSEPPI------EMIAPGVWDGS QPSP------LTLQ-----IDFPDAGW---E--YLKPES--------EEN---------- ------------------------------------------------------------ -------RTDHEEP---PREC----LKHIAKLS----QKKSPLLLSEEKRRYLWFY-RLY C-NNENSSLPLV-LGSAPGWDEETVS---EMH---AILRRW-----TFSHPWEALGLLTS RFPDQDIREVAVQQL-DT-LLTDELLDCLPQLVQAVKFEWNLESPLVELLLRRSLQ--SI RVAHRLYWLLRDAQ-G------E-----------------------AYFKSWYQELLAAL QFCAGEALNEELSKEQKLVKLLGDIGEKVKSA--S---DPQRK----------------- DVLKKEIGSLEE-FF----KDIKTCHLPLNPALCIKGI-D-RDACSYFTSNASPLKITFI NANPM-----GKNI----SVIF--KAGD--DL-RQDMLALQIIQVMDNAWLQEGLDMQMI TYGCLSTGRAQ---GFIEMVPDAVTLAKIHL---HSGLI-GPLKENTI--KKWFSQHNHL KE-------------------------DYEKALRNFFY-SCAGWCVVTFILGVCDRHNDN IMLTKSGHMFHIDFGKFLGHAQTFGGIK--RDRAPFIFTSEMEYFITEG--GK----NTQ HFQDFV---------------ELCCRAYNIVRKHSQLILSLLEMMLHA-GLPELRGIEDL KYVH--NN-LRP-QD-TDLEATSHFTKKIKESL-ECFPVKLNNLIHTLAQMPALS-LAK- PAPQTLLQESCILNKTRTIQRVTILGFSKT----HSNLYLMEVTCSDNR--RSLTKKSFE QFYRLHSQMQKQFSSLALPEFPHWWHLPFT---DSDHKRIRDLSHYVEQVLRGSYEVANS D-----------CVLSFFLSEHIQPTLEDSPFVDPG-KN------------SLDK-SPKV QLLMTYEDSRLTILVKHLKNIH-LPDGSVPSAHVEIYLLPHPSEVRRKKTKCVPKCTDPT YNEI--VVYDEVL--GLQGHVLMLIVKSKTV------FVGAVNIQLCSVPLNEE--KWYP LGNSII--- >T_nigroviridis_ENSTNIP00000008764 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SSTVDLLIYQTLCYALDDLDH- ------------LD-VQEYLLKVCGYDEFLDH-S-QTLAA-LE--LV-QQS-LKFDW-NI RLFLIK--KSKI--NTE-----LARTEEDDQTMSTMNHNILLQERPIKQTVTSREALSLL LDTFHIEAESFLLSEAE-------------------LLLHVERLVQSVKALCSSLAA-VE SPEVTAAL--SQLPA---CPCRLQPRV------------------------LKDA-SVL- -------------------AVRSNRERVVEKLTAAILDLLELYCSTFN-ANFHT------ -AQQSR--RNTPVQE--------AGFLASV-VSFNIYAAHR---------IPITWATSYE GFFLSCSLTHGGA-LCA-PQHT----SKQLVSK-YLYHLV-VW-DQRVC-F-PVQINQLP RESQLTVTLYASAL----PPPGG-----------AEEKGKQR-------RSVEALGWVTM PLFSFR-H----------------VLTCGRKLLGLWPPTPGKT------GGARTSSPNFS QPDS------VILQQ----LDFPSSSF---DVVFSTPPP--------ADFC--------- ------------------------------------------------------------ -----P-RYDFAAL---DTIS----QIQLQDVL----HKKAVFWLTADDRRLLWEK-KSF C-QSESSALPLV-LASAPCWQWSCLP---EIY---ALLRQW-----SCPRHLDNLGLLHA SFPDQEVRRMAVQWM-DP-MSHTELLDVLPQLVQALKYECYLDSSLVRFLLRRAMR--DI RIAHYLFWLLKDNL-Q------H-----------------------SQFTARYHHLLAAL LCCVGRGLREEFDRQCWLVSILANVAHRVRDA--A---PSSRQ----------------- CVLREALEEMSQ-FF----SVNSSCRLPLNPALHVKGI-N-IQLCSFFNSNAVPLKLSFQ NLDPL-----GDHI----NVIF--KSGD--DL-RQDMLTLQVIRIMNKIWIQEGLDMRMV IFKCFSTGRGR---GMVEMIPHADTLRKIQV---EHGVT-GSFRDRPL--ADWLQKHNPT EE-------------------------QYDKAVENFIY-SCAGCCVATYVLGICDRHNDN IMLKSSGHMFHIDFGKFLGHAQMFGNIK--RDRAPFVFTSDMAYVINGG--DK----PSS RFHDFV---------------DLCCEAYNLIRKHTHLFLNLLGLMLSC-GIPELSDQEDL KYVY--DA-LRP-HE-SEADATMYFTRYFVNSP-SPVPPKREPPLWSPPRLPFAR----- -PSLSFAPRL-LAKSGGVISNLYVCRHISTANSSKGHAFVVKVQKDGHK-EALFVQRTFE EFNELHSKLRLLFPASKLPRFPNRLVIGRS-SDATADRRKDELNAYLWHLINSPPEVAQS D-----------LVSTFFHPLPRDERAASSNS-----SK--PPEVLWS--AASGKELGQV KLSISYKNDKLFIMVMHIRGLPSMQDGTDPDPYVKLYLLPDPQKTSKRKTKAARRTCNPT YNEM--LVYERIPQGDLDQRVIHLRVLGDGAFWENTLLLGETFIPLKKLVPDQHWVDWHQ LRAAGSGST >O_cuniculus_ENSOCUP00000004818 ----------MAQISSNNGFKQCSSSSLEPIRTKD-VDKEEALQMEAEALAKL-KD-RQV T-----------------------------------------DNQRGF---ELSSSTQQK AQ-VYN------------------KQDYDLMVFPESDSQKRA-----VDIDVEKLTQAEL EKLLLDDSFETKKTPVLPVTPVLSPSFSAQLYVGP-----------TIQRGQWPPGLSGP ------------S-YTL-------PTIYPS-TY-GKQAAFQNGFNPRMPTFPSTEPIYLS LPG-Q---SPYFSYPLTPTTPFHP-QGSL------------------------------- ------------------PVYRPVVSPEMAKLFDKIA-----STSEFLKNGKARTDLEIT NSKATVSNLQVSP--------KSESIS--------------------------------- ---------------KFDWLDLDPLSKPK-VDNVEVLGHEE--------------EKNIP NLLAED-------------------PWDAVLLEERSPA---NCHFERKVNG--------- KSLSGATVTRSQSLNIRTTPLT-------------------------------------- -----KVQ-----------GQIFQ---KDPNGTSSLPTGS-------SLLQEIEVQNEEV AAFCQSITK---LKTKFPYTNHCT---NPGYLLSPVTVQRN-ICGENA-SVKVSI----- -----------------------EIEGFQLPVTFTCDXXXXXXXXXXXXXXXXXXXXXX- ------------XX-XXXXXXXXXXXXXXXXN-N-HCLG--HE--HI-QNC-RKWDT-EI KLQLLT--YSAM--CQX-----XXXXVEDDEAPVDLNKHLYQVEKPYKEVMT-RHPVEEL LDSYHNQVELALQIE-N-------------------QHRGVDQVVKATRKICSALDG-VE TPAITESV--KKLKRAVNLPRSKISEX-------------XXXXXXXXXXXXXXX-XXX- -------------------XXXXXXXXXXXXXXXXXXXXXXXXX-XXX-XXXXX------ -XXXXX----XXXXX--------XXXXXXX-XXXXXXXXXX---------XXXXXXXXYE KYYLMCSLSHNGKDLFK-PIQS----KKVGTYK-NFFYLI-KW-DELXX-X-XXXXXXXX XXXXXXXXXXXXXX----XXXXX-----------XXXXXXXX-------XXXXXXXXXXX XXXXXX-X----------------XXXXXXXXXXXXXXXXX-X------XXXXXXXXXXX XXXX------XXXX-----XXXXXXXX---XXXXXXXXX--------XXXX--------- ------------------------------------------------------------ -----XXXXXXXXX---XXXX----XXXXXXXX----XXXXXXXLSKEDKAFLWEK-RYY C-LKYPNCLPKI-LASAPNWKWVNLA---KTY---SLLHQW-----PPLYPLTALELLDS XXXXXXXXXXXXXXX-XX-XXXXXXXXXXXXXXXALKYEIYLNSTLLHFLLSRALG--NI QIAHNLYWLLKDAL-H------D-----------------------AQFGARYEHVLGAL LSVGGKGLREELYKQTKLVQLLGGVAEKVRQA--S---GSARQ----------------- VVLQRSMERVQS-FF----LRN-KCRLPLKPSLVAKEL-N-IKSCSFFSSNAVPLKVTMV NADPM-----GEEI----NVMF--KVGE--DL-RQDMLALQMIKIMDKIWLKEGLDLRMV IFKCLSTGRDR---GMVELVPASDTLRKIQV---EYGVT-GSFKDKPL--AEWLRKYNPS EE-------------------------EYEKASENFIY-SCAGCCVATYVLGICDRHNDN IMLRSTGHMFHIDFGKFLGHAQMFGSFK--RDRAPFVLTSDMAYVINGG--EK----PTI RFQLFV---------------DLCCQAYNLIRKQTNLFLNLLSLMIPS-GLPELTSVQDL KYVR--DA-LQP-QT-TDAEATIFFTRLIESSL-GSIATKFNFFIHNLAQLRFSGVPSND EPILSFSPKTYSFRQDGRIKEVSVFTYHKKYNPDKHYXXXXXXXXXXXX-XXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXASAEVAEC D-----------LVCTFFHPLLRDEKAEGI-------AR--SADAGPFS-PTPGQIGGAV KLSVSYRNGTLFIMVMHIKDLV-TEDGADPNPYVKTYLLPDTHKTSKRKTKISRKTRNPT FNEM--LVYSGYSKETLRQRELQLSVLSAESLRENF-FLGGITLPLKDFNLSKETVKWYQ LTAATY--L >D_melanogaster_FBpp0075819 ----------MSNQ-AHIDYDKQFQDD---------LAKATALSLEQHALDDYRRNKKYG S------------------GYQQSSTVAGRDYQAA-------QRSQSLHQP-------RR HSEVHQVAISPENAERSRTPPAQGTDN-DLICFAS---PTSKQPESSSP--FGKLIEDLQ RMQ--PTNP---QSALVPMGPVASASIPPQYGF--PPHQ------QRPTAAQPTPYGMVA GGVVGGPAYGDLQLVPYQPAAQQQRPLNSEELQRLYSMPAQMAVVPVPQPNAYMY---YP GAVVT-----------PYTAPIVPGSAAF--------MP-PQYPAQGYGFGG-------- -----------------AYTHMDLRRPQSQ--PAPQQ-----TAPT------TSHHHSQP SNHSTSSPAEANGVAFPARRQVPSTVGVSSSSH------TGNNGHSS------VPRR--- ---------------GNDLIDL-NHEDYSRVSVLEAFDPLLNDN------TGNDTASDST S-YYAEYDPFDFLYSGDAATQYSDPMYEAV---NRWDKTVATVSPNVGLIG-----WRQD FLSQPST--SSSQYGVAPPEESLKLAENGSGTISP-------PPPLPPRNQQCYESNQAA M----PVSRPPQSSVLTDSYTSSIPANVVLDRRKTCTRLY-------ELISDQRTDDPEL LEFYHMVKE---VRARYPHDDAPT---NVGHVVAAEFNYHY---MMDT-SIKVIVH---- -----PALNTLQSTVLAASMGKEQVKGYGMPVTFTCDIDSVVAQVVAQALASLEGQVKG- ------------T--VTDYAVKPIGLLEWLAP-T-SRLSQ-LE--CV-HNS-FQLEK-DV HLGLCL-STAAN--MQA-----IARTERDDEHDADLLPE-HLLPNEVVPIVT-YDNMMIL IETLEMEIDKLESAADG---------------VPGRSVVSCSGVVQAVKAICALLGS-ID TMEIARCV--ADLKRICEVEQKKYSTGAS----------NPEIVSDYGDYAQVVL-RPR- -------------------SMLEQIKVKCNELRDAVQELVELYANVFR-VAFSV------ -KTPDY---STTPIP--------ISCVSKP-IVVCISCLHR---------PLPNW--KFD DYSLCVQIVYGTRLLSK-PNVL----TCSNDTSGGLFPRL-NF-SAWLT-FDQHPICTLP REARLTFVLYG-----------KQAASEGEPNA-DQNG-ERR-------QVTTELGWCSI QLFDFK-R----------------VMICGPYLLSLWPPMTD--------KMLGPAPARGC HPQPDF---CPVLS-----IEVPPYGG---RIEFPEHQE--------VPKP--------- ------------------------------------------------------------ -----APHYDFASL---DANL----QEELLDTA----ELGYT-G-ATERREVFWEK-RLY L-QSYPNALPKV-LHAAHSWDYANLI---DLH---ALLHSW-----APLSPLQSLELLLP RYPDAKVREKAVEWI-SK-MPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLSKCLE--SP RFAHHMYWLLVHSL-P------DD-PHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLRAL MAICGEKMLQRFMYQHRMCQKLTTIAESVKEA--K---ESMRQ----------------- KSLAAGMDEVHQ-DL----LEQ-PTCLPLGPELEVTGV-S-VRNCSYFNSNTLPLKINFV GPD-------AESL----PAIF--KCGD--DL-QQDQLTIQLIRIMNKMWLAERLDLKMV TFNCVPTGYKS---GMIELVSEAETLRKIQV---ECGLT-GSFKDRPI--AEWLGKQNPS PL-------------------------EYQSAVRNFTL-SCAGYSVATYVLGICDRHNDN IMLKTSGHLFHIDFGKFLGDAQMFGNFK--RDRTPFVLTSDMAYVINGG--DK----PST DFHYFV---------------DLCCRAFNIVRKNADLLLHTLAHMATA-GMPGVN-SNAV QYVR--RA-LLP-SQ-SNPEAAATFAKMIQSSL-KSWFTQFNFFLHNLAQMRFTP-DEGS GELLSFVPRKYTMQQDGRLKIVKVVCFQKHYSMEKFYMYILEVTRHGQP-DPTHLFRSYR EFTEFHQKLCMHFPLVKLHSLPAGVHVGRSNIKSVAEKRLPLIQRFLKSLFDASEEIAHS E-----------LVYTFFHPLLRDQQEAKLGM-----PKIKEVKQQPSR-DNPHEI-GQI RLSLQYQRGVLTVMIHHAKGLPMLQGGQEPNTYVKCYLKPDPKKETKRKTKVVRKTCVPS FMET--LEYR-MPLNIIQERRLQVTVWSHDTLQENE-LLGGFDMDLSKYDLRQELVDWYR LGAVSR--N >T_rubripes_ENSTRUP00000043605 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------I-------RLIDCPEGSTGAL TSFCAATSH---LLSRHEHTDEVH---NSGVVWGRVSQVHA-ALLQQV-EVTVSV----- -----------------------ATEWNQSQLPLATTLNRTVKSLIGELLQLLQPAPGT- ---------------CQGYVLKLCDSEEYLQN-E-EVLGT-HD--SI-QRY-HKYEL-AV PLRLLP--LSGA--KHR-----LARDLEDDRRPCQLYPHL---RHAGVFSTS-RLNLQQM LSSYNREMMELMRSKVG-SGGRGRTTVRGCVCVACPPAMSVNVVVDHVRTICKLLCG-LS SQELEEAI--GRLNSSMIGNVFIFLQSQ-------------------------------- -------------------EEKTECETAMVVLHSALLKLLQAFFDNFQ-SDFRV------ -QEATE---KRQIRD--------VEENADV-FQFTISALYQ---------LQTSWTSSYE CFSVSCDLTYGTTKICE-TGIS----QNISTAL-CYGNKI-QC-NRMMV-F-PVPVHQLP YECMLTFRLKG---------------------------SKRG-------KNPELLGWAVL PLYTHS-H----------------KRAVGVVLQVSGLDSSSSF----QPEHKRVYGSVIC PP--------VSPQ-----LEFPDHF----DWQYRRPLA--------L------------ ------------------------------------------------------------ -----PGMISFTGP---SEEL----QRKMLAVS----KKHCLCFLTENEKTFLWTK-RYH S-DKSSTFLHLL-LGGAPRWQPEDLT---EIY---TVVENW-----PIYLPEEALLLLSN NFPDPTVRRAAVHFF-EQ-VPDGDLEVFLPQLVQALKSEWELDGPLVMLLLERSVK--NI QVAQQLYWLLEDAQ-T------D-----------------------PYYQSWLAKIQAAL QHCCGRALRKELELETRLTSALVQVAEKIRAA--E---KTRRK----------------- SILKKEAAQIED-FF----KDGISCCLPLDPAVRAQGL-D-VDACKVYNSNAAPLGISFI CTDPL-----AKNV----SVIC--KTGD--NL-RQDMLVLQIVRMMDRVWLQEGLDLRMV TYRCLSTGKAQ---GLVEVVPEAVTLGKIQQ---EWGLA-GSLREDTL--EKWFHMWNKT KE-------------------------DYDKAVMNFIH-SCAGWCVATFILGICDRHNDN IMLKHSGHMFHIDFGKIMGNAQKFGSFK--RDRSPFIFTSEMQHFITGG--GQ----KPQ RLHRFV---------------ELCCEAYNIIRQRSALILSLLELMLPA-GMPELKDGNDL QYVQ--NN-LRP-HD-SDLEATSYFTKKIKESM-GCVAVKINFLTHSMAQGK-----KQE PLTRNGIPSPSSNIQEAVIQGFTVRG--------KDAVYDLRVTIDDGY---LNSETTYG QLERIHKQLQKYFIESALPQFPGWYKMSFN-----QSKRMSLLNKYLKQLFEGPCKGVGS DPPDLSQQFDNEFVCSLFLDGPKKDQ------------------------DTFTMARPQI QLYISYSNFKLSVLVKHLKNIK-NSNGTNPDAYVVLRLRPDPKQRSKRKTKVVRNNDNPT FNEL--LEYSSVP--VLYGMVLEVVVKSKKT------FVAATNIKLEEELLDKE--KWFA LGNCAI--- >G_gorilla_ENSGGOP00000009368 ---MCFSFIM-------------------------PPAMADILDIWAVDSQIASD--G-- ------------------------------------------------------------ ---------------------------SIPVDFLLPT-GI--------YIQLEVPREATI SYIK-QXXXXXXXXXXXX------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------XXX---XXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXX --XX-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----XXXXXXXX-----XXXXX----X-XXXXXXXXXXX-------XLHEFDSLKDPEV NEFRRKMRK---FSEEKILSLV-G---LSWMDWLKQTYPPE--HEPSI-PENLED---KL YG---GKLIVA----------V-HFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGK- ---ED-------EVSPYDYVLQVSGRVEYVFG-D-HPLIQ-FQ--KI------------- ---------------EM-----YK------------------------------------ ------ITIKSSSS---------------------------------------------- ----PPE----------------------------------------------------- ------------------------------------------------------------ ---------------H-------VWENNNP-FQIVLVKGNKLN-------TEET-----V KVHVRAGLFHGTELLCK-TIVS----SEVSGKN-----DX-XX-XXXXX-X-XXXXXXXX XXXXXXXXXXXXXX----XXXXX--XXXXXXXXXXXXXXXXX-X-----XXHYPVAWVNT MVFDFK-G----------------QLRTGDIILHSWSSFP--D-E--LEEMLNPMGTVQT NPYTEN---ATALH-----VKFPENKK--QPYYYPPFDK--------IIEK--------- -----------------------------------------------AA-EIA-S----- -----SDSANVSXXX--XXXX----XXXXXXXX----XXXXXXXXXXXXXXXXXXX-XXX XXXXXXXXXXXX-XXXXXXXKLEDVA---QLQ---ALLQIW-----PKLPPREALELLDF NYPDQYVREYAVGCL-RQ-MSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALG--NR RIGQFLFWHLRSEV-H------I-----------------------PAVSVQFGVILEAY CRGSV-GHMKVLSKQVEALNKLKTLNSLIKLN--A---VKLNR-A-K------GK----- EAMHTCLKQSA--YR----EALSDLQSPLNPCVILSEL-Y-VEKCKYMDSKMKPLWLVYN NKVFG-----EDSV----GVIF--KNGD--XX-XXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXX--XXXXXXXX-X XD-------------------------DLDRAIEEFTL-SCAGYCVASYVLGIGDRHSDN IMVKKTGQXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXX--XX--X-XXX XXXXFR---------------QCCEDAYLILRRHGNLFITLFALMLTA-GLPELTSVKDI QYLK--DS-LAL-GK-SEEEALKQFKQKFDEALRESWTTKVNWMAHTVR----------- --------------------------------------------KDYRS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------- >A_gambiae_AGAP011036-PA ----------MATNPNDLEFEKKYLAD---------IERAMALSLETLELEKIRARQRQM TPELANDPKAVSQTLEEYRAYLQRRVACGTGKVAATPAPGAGTSSSTLEPPPGGGPAVRR HSDSRNPGIQ--------GPPARGKDEADLISFSAVPKPPDPKEEARNN--LKELVEQMH RYAPPPQPPVGQFEQGFKTQRSLSMSAA-SYGFHQAAYQPVGVPGQAHLQGPYNAAAM-- ------------QLVPYSSQAAKPKPLTPDELHRLYNSPPMYAVATAGGPAAMVVPPAYP GTVAYGGVPAYGTV--PTMANYGPAHQAP--------LPQPSAGAAPFGVGG-TPGTPLY PALQQTTGMNGTTGSTTSTSSSTVANPETALVHV----------PKLGAAGRSYSQPQAV LASALRRQASP------ARGEQPA--------------------------VVMRPKSDPA NGGAGPSQQQRLGAKGTDLIDL-GFEDNPRVSVLEAFDPLLCGNRSSSGSSGDDDKDDTA STYYEDYDPFDYIYSG--GTQYSDPVYDAVVNRSLSDKTGTPLSPPASLYG-----AVGV LPPPPGTPGGSCTYGWVNAPVE---ASSSSSTQSPVGGGDGEPPPLPPRNSTAAAGYSHT MLRGIPAGQADEQSNYEIMQRKLAPASGV-ERRATPYKLY-------ENVVIAKSYDKEL IAFYSMVKQ---LRAQYRHDDEAT---NVGHIVAAEIENRY---VEGT-SIKLLVH---- -----PALDCFAG----GEQTKGQIDGYGPPIPFTCDITTTVEHVIAQVYCALEGQIRN- ------------T--VSDYALKAIGIQEILCV-R-SRLNQ-LQ--CV-HDS-IKLEH-DV QLGFVA-KTART--MRV-----IARTAQDDGRDADMRLE-HLLPKETSHAIG-YDDLMIL LETLEAEIDKLQSSADD--------------GPSGRTILTCSGVIQAVKAICNLLGP-LD TLEIAKSI--EDLRACCDQGQTVYSYRDSVVSDEAYSNGSLAIVSESGDYAEVKL-RPR- -------------------TVAEQIRYRCNEVRHAIQSLLEIYAQAFR-VNFSV------ -NVPEY---NANPIS--------ICNISQA-VMVNVSCLHR---------PPLHW--RHD EYNLGVQIYHGARYISE-PYVV----QCSNELS-GIYPRL-TF-NSWIM-F-RNPVCTLP REARLVVVLYGCVR----EPVDGGGTSDGAPGVNDPGGSEGR-------MTKVELGWSSL QFFDFE-R----------------KMVQGSYLLPMWPPTTD--------KFFGPAPSKGT YPIGGS---FPILS-----IEIPSYGG---AVVFPEPIR--------NLPP--------- ------------------------------------------------------------ -----VVQLDFASL---DRNL----QQELIDTA----EQGYS-PDKLEKREVLWEK-RHY L-HRFPHALPKI-LHAAHSWDYACLS---DLH---ALIKSW-----TALSPVQALELLLP RYPDLEVRRQAVEWI-AA-MPNDEFVDYLPQLLQALKHDTYEGSPLAMLLLRKSLE--SP RIAHHLYWLLLHSL-P------GEAPQNMIDAQ--ETACDAVLMNQARYHRRNQLMLRAL LAICGEKLTGRFLSQNMMCKRLGEVAQSVKLA--K---DSHRL----------------- QVLKQGLESVNQ-LL----IDG-PTVLPLEPGAEVTGV-I-VRSCNYFNSNTLPLKINFA GPD-------RVVV----PAIF--KAGD--DL-QQDALTIQMVRIMDKMWLREGLDLKMV TFNCVPTAYKK---GMIELVSESETLRKIQV---EWGVT-GSFKDKSI--AEWLAKQNPS QL-------------------------EYQRAVENFTR-SCAGYSVATYILGICDRHNDN IMLKTSGHLFHIDFGKFLGDAQMFGNFK--RDRTPFVLTSDMAYVINGG--DR----PSA KFHQFV---------------DLCCTAFNIVRRHSDLLLHMFALMATS-GIPGVT-VEAV NYVR--NA-LLP-GQ-SNPEAAATFAKMIHISL-KSWFTQFNFFLHNIAQMKFSA-ESGD GELLSFIPRVYTMAQDGRLKTVYVHGYQKRYDQEKYYTYILRVERQHQP-DAAYLFRSYK EFCEFHQKLCMHFPLAKLHSLPSGIHVGRSNVKVVAERRLPEIRQFLISLFNSADEIAHS D-----------LVYTFFHPLLRDQQEADISS-----AKVKGIPAAMED-GQPPQVGGKI KISMQYHRDTLIVMIHHVVALPNTPGGQPPNTYVKVYLKPDSSKATKRKTKVVRKNCNPS FMET--LEYR-LPLEFIQKKVLHVTIWSHDSLQENA-FLGGIELPLAE------------ --------- >G_gallus_ENSGALP00000021380 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GWSI-------QLIKANQGSNENA VSFCNTVEK---IRNTYPACDLKT---NTGKIWSVATKFPD-HILGKI-RLRISI----- -----------------------WTDSSPSPLLLTQHAGCITHDLIVEILR-CTNQ--Y- ------------PV-HEECLLSVCGSDEFLQN-N-HSLGN-HE--SL-R----KATT-DI HLHLHS--TTNL--KQS-----LARVHEDDQGRFSVNELL---EYTCAWRLT-RQNLFAA LRKYRGQVEHLLQNEENPYKV--------------------DYVIEVAKAICSVLCF-VE TRQITSAV--KKLHA---VPLVKTQPV-------------------------HSS-TTS- -------------------SVKTLTEAAVTELSMAISHLIHVYSSSFD-TDFQV------ -ANIPR----SPSRA--------DISLDSQ-LSFTVYAAHN---------IPEAWVNR-- -----------------------------------------------IN-F-PLRIKALP RETMLTIKLLGL--------------------------NSAS-------KTTEMLAWTCC PLYQKE------------------QLIHGTVLLSMKLYSMLPA------AMITPAMCSTD APTS------VTLQ-----IEFPETDL---E--FINPEP--------EER---------- ------------------------------------------------------------ -------RDDLAEP---TEEC----MKHIARLS----QAHSLLLLSEQQKRILWFY-RYY C-NNQNCSLPLV-LGSAPSWDRTTVS---EMY---SVMRKW-----RFSNPVEALGLLAF SFPDKDIRRTAVQQI-EN-LSNDELLEYLPQLVQVLKFEWSLEGPLVKLLLNRSLQ--SI QVAHQLYWLLKNAQ-N------E-----------------------VHFKVWYRKLLAAL QFTAGKALNNEFSKEEKLIRILEDTAEKVKVA--S---DAKRK----------------- EVLKMELNRLQQ-FF----QEVKVCRLPLNPALVVQGI-E-ADSCSYFTSNAFPLKIRFI NANAP-----SGNI----NIIF--KIGD--DL-RQDMLVLQIVRVMDNIWLQEGLDMQMI IYRCLSTGKGQ---GLVQMVPDATTLAKIHR---ESGLI-GPLKENTI--RKWFRHHHRL ES-------------------------SYQEAIRNFFH-SCAGWCVVTFILGVCDRHNDN IMLTNSGHMFHIDFGRFLGHAQTFGSIR--RDRAPFIFTSEMEYFITEG--GK----SPQ RFQEFV---------------ELCCRAYNIVRKHSQLLLNLLEMMLHA-GLPELNSIQDL KYVY--DN-LRP-QD-SDLQATSYFTRKIKESL-ECFPVKLNNLIHTLAHMSLAG-SAKF PSQETVPQEWMMLNAEKSIARATILGFNKK----SDYLYLVQVVQTCSL--VTFVEKSFD QFSELHSNLQKQFPSHALPEFPHSWHIPFT---DLEHKRVKDLNLYLKQLLSGSRKLANN E-----------LVLSFFLNWSKHTLAEAASSVTSG-PQ------------STDG-TPGV QLVISYEGTHLTVMLKHMRNIR-LPDGSAPSAHAEFYLLPDPGEVNRRKTRTVPKTTNPT YNEI--VVYNKVM--QLEGHILKLVVKSKGT------FVGAVNIQLSRVQLNEE--KWYP LGNSVI--- >T_guttata_ENSTGUP00000012743 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GWAI-------QLIEADQGSNENT VDFCNAVEK---IRNAYPAFDLKT---NTGKIWSITTRFPE-HILGAT-KFRLSI----- -----------------------WTDFSPHPLLLTQHAGCIIHDLIVEILR-CTNQ--Y- ------------PAREEECLLSVAGSDEFLQN-N-CTLGS-HE--SL-R----KAST-CI QLRLHH--AGNL--EHS-----LARTCGDDQRRFCVNELL---EDTHAWRLI-WQNLVSV IMNYRGQVEYLLQNEQN--NV--------------------DNVIEAAKAICSVLCF-VE TRDITDAV--SKLHA---LGRAQVKDA-------------------------CSC-PTV- -------------------IFKTLIEAAVTELSMAISRLIRIYSSSFD-VNFQL------ -ASVPR----SPLCA--------DISLNSQ-LSFTVCAAHN---------IPEAWVTR-- -----------------------------------------------VN-F-PLRIKALP RETMLTIKLLGL--------------------------NSAS-------KNTEVLAWTCS PLYAKE------------------RLIRGTVLLSLAPCSTLPT------AVITPGICSTE APTS------ATLQ-----IDFPETDL---K--FIKPEP--------EER---------- ------------------------------------------------------------ -------RGDFVEP---TQEC----LKNIARLS----QKHSLLLLSEQQRRILWFY-RYS C-NNQNCSLPLV-LGSAPSWDRTTVS---EMY---ALLRGW-----RFSDPLEALGLLTF SFPDQDIRRAAVQQM-EN-VSNDELLEYLPQLVQVLKFEWTLESPLVKLLLNRSLQ--SI QVAHQLYWLLKNAQ-N------E-----------------------VHFRMWYKKLLAAL QFCAGQTLNNEFSKEEKLIRILEDIATKVKAA--S---DPKRK----------------- EVLKVELSRLQQ-FF----QEVKLCRLPLNPALVVQGI-E-ADSCSYFTSNAFPLKISFI NANAP-----SGNI----NVIF--KIGD--DL-RQDMLVLQIIRLMDSIWLQEGLDMQMI VYRCLSTGKGQ---GLVQMVPDATTLAKIHR---ESGLI-GPLKENTI--KKWFHHHHPL ES-------------------------SYQEAIRNFFY-SCAGWCVVTFILGVCDRHSDN IMLTKAGHMFHIDFGRFLGHAQMFGNIR--RDRAPFIFTSEMEYFITEG--GK----NPQ RFQEFV---------------ELCCRAYNIVRKHSQLLLNLLEMMLHA-GLPELNSIQDL KYVY--DN-LRP-QD-SDLQATSYFTRKIKESL-ECFPVKLNNLIHTLVQMSVGS-SAKP PAPETVPQEWTVLDTERSIARATILGFSRK----PDSVYLIQVVQTCNV--VTFVEKSFH QFSKLHSHLQKQFPSHALPEFPHSWHLPFT---DLEHKRVKDLNLYLKQLLSGSRKLANN E-----------LVLSFFLNWSKNTLAEHSSSLTLG-PQ------------SAGH-KPGV QLVISYENTRLTIMLKHMRNLH-LPDGSAPSAHAEFYLLPDPCEVSRRKTRTAPKGSDPT YNEL--IVYDRVS--ELQGRVLKLVVKSKGT------FVGAVNIQLSSVQLNEE--KWYP LGNSVI--- >R_norvegicus_ENSRNOP00000049061 -------------------MAYNWQTEPNRAEPQEGGHDHQQCHHADQHLSSRQVR---- ------------------------------------------------------------ -------------------------------------------------LGFDQLVEELS NKTPLPEDE-KEGTCFVPDTPNLDSKWQSIYGPHP------------------------- ------------------RHFNEFTSQSPHFSQLPFGKASAIGFNPAVLP---------- ----A---HQFIHEGASWRNPTRKYHGGE------------------------------- ------------------DPRFSALTPSSTGLDKCHQ-----QGQSGTEHCNYYVELENN IPHHYSPYSMDSI----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PDSEEKGSGDADLVEPSLV-------------------------------------- -----FSK---------DSFLPRASENMSVESTEPIGCPL-------EIVEAPQGSNKSL ASFCNNVTK---IRGLYHASDTNS---NSGKIWAITTAYPS-RLFADT-QFRVKI----- -----------------------STDNSAQLLLLKPPANYLVKDLIAEILLLCANE--Q- ------------LS-PKEYLLSICGSEEFLQT-D-HCLGS-HK--IF-Q----KSKS-VI QLH-QR--SRDT--PGK-----LSRKRDDDRSRVHLNQLL---EFTHIWKIS-RQCLSTV MKSYNLHVEHLLKTQED---VEEKPLSSMFSCGRHPPQPHGNDIIEDVRNICSVLGC-IE TKQVSDAV--KELTL---ILQRPSQNF-------------------------HQN-SET- -------------------SKKGFIENVTSELSRSLHQLVDVYCSSFC-TDFRP------ -ARAPG----GVSRD--------HAGLHSH-LSFTVCSLHN---------VPETWAHSYK AFSFSCWLTYAGKKLCQ-VKSC----RSLPVTK-SFSFSV-NW-NEIIN-F-PLEIKSLP RESMLVIKLFGI--------------------------DSAT-------HSANLLAWTCL PLFPKE------------------KSPLGSRLLSMTLQSEPPI------EMMAPGVWDGS QPTP------LTLQ-----IDFPAATW---E--YVKPET--------EEN---------- ------------------------------------------------------------ -------RTDHQEP---PREC----LKHIARLS----QKQSPLLLSVEKRRYLWFY-RFY C-NNENSSLPLV-LGSAPGWDEGTVS---EMH---AVLRRW-----TFSHPLEALGLLTS RFPDQDIREVAVQQL-DN-LLTDELLDCLPQLVQAVKFEWSLESPLVELLLHRSLQ--SI RVAHRLFWLLRDAQ-G------E-----------------------DYFKSWYQELLAAL QFCAGEALIEELSKEQKLVKLLGDIGEKVKSA--G---DAQRK----------------- DVLKKEIGSLEE-FF----KDIKTCHLPLNPALCVKGI-D-RDACSYFTSNALPLKITFI NANPM-----GKNI----SVIF--KAGD--DL-RQDMLVLQIIQVMDNVWLQEGLDMQMI IYGCLATGKAQ---GFIEMVPDAVTLAKIHL---HSGLI-GPLKENTI--KKWFSQHNHL KE-------------------------DYEKALRNFFY-SCAGWCVVTFILGVCDRHNDN IMLTKSGHMFHIDFGKFLGHAQTFGGIK--RDRAPFIFTSEMEYFITEG--GK----NTQ HFQDFV---------------ELCCRAYNIVRKHSQLLLSLLEMMLHA-GLPELRGIEDL KYVH--DN-LRP-QD-TDLEATSHFTTKIKQSL-ECFPVKLNNLIHTLAQMPAFS-LAR- PAPQTPPQECCVLNKTRTIQRVTILGFSKT----HSNLYLIEVTRSDNR--KNLAKKSFE QFYRLHSQIQKQFPLLTLPEFPHWWHLPFT---DSHHERIRDLSHYVEQVLHGSYEVANS D-----------CVLSFFLSEHIQQTLEDSPFVDPG-NH------------GPDKHSSRE QQIISHEDKRFSFVIFHLKCYH-LPDGSAPSAHVEIYLLPHPSEVRRKKTKCVPKCTDPT YNEI--VVYDDVS--GLQGHVLMLIVKSKTV------FVGAVNIQLCSVPLNEE--KWYP LGNSII--- >M_mulatta_ENSMMUP00000029190 -------------------MAYSWQTDPNPNESHEKQYEHQEFLFVNQPHSSSQVS---- ------------------------------------------------------------ -------------------------------------------------LGFDQIVDEIS GKIPHYESEIDEDTFFVPIAPKWDSKGHSLNEAHQ------------------------- ------------------ISLNEFTSKSRELSWHQVRKAPAIGFSPSVLP---------- ----K---PQNMNKECPWGSPRGKHHGAD------------------------------- ------------------DSRFNILAPSFTSLDKINL-----QKELENENRNYPIGFESS IPPTNSSFSTDFM----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PKEENKRSGHVNIVEPSLM-------------------------------------- -----LLK---------GSLQPGMGESTWQKNIESIGCSI-------QLVEVPQGSNTSL ASFCNNVKK-----EYWYFIKLKFLCLNKFVYFDITELINL-AYKSQS-P----V----- -----------------------IPEHTHTHTHKFLITNYLVKDLIAEILHFCTND--Q- ------------LL-PKDHILNVCGSEEFLQN-D-HSLGS-HK--MF-Q----KDKS-VI QLHLQK--SREA--PGK-----LSRKHEEDHSQFYLNQLL---EFMHIWKVS-RQCLLTV IKKYDFHLKYLLKTQEN---V--------------------DNIIEEVKNICSVLGC-VE TKQITDAV--NELSL---ILQRKAENF-------------------------YQS-SET- -------------------SAKGLIEKVTTELSTSIYQLINVYCNSFY-ADFQP------ -VNVPR----CISYL--------NPGLPSH-LSFTVYAAHN---------IPETWVHR-- -----------------------------------------------IN-F-PLEIKSLP RESMLTVKLFGI--------------------------ACAT-------NNANLLAWTCL PLFPKE------------------KSILGSMLFSMTLQSEPPV------EMIAPGVWDVS QPSP------VTLQ-----IDFPATGW---E--YVKPDS--------EEN---------- ------------------------------------------------------------ -------GSNLEEP---PKEC----LKHIARLS----QKQTPLLLSEEKKRYLWFY-RFY C-NNENCSLPLV-LGSAPGWDERTVS---EMH---TILRRW-----TFSQPLEALGLLTS SFTDQEIRKVAVQQL-DT-LLNDELLEYLPQLVQAVKFEWNLESPLVQLLLHRSLQ--SI QVAHRLYWLLKDAE-N------E-----------------------AYFKSWYQKLLAAL QFCAGKALSDEFSKEQKLIKILGDIGEKVKSA--N---DHQRQ----------------- EVLKKEIGRLEE-FF----QDVNTCHLPLNPALCIKGI-D-HDACSYFTSNALPLKITFI NANPM-----GKNI----SLIF--KAGD--DL-RQDMLVLQIIQVMDNIWLQEGLDMQMI IYRCLSTGKDQ---GLVQMVPDAVTLAKIHR---HSGLI-GPLKENTI--KKWFSQHNHL KT-------------------------DYEKALRNFFY-SCAGWCVVTFILG-CDRHNDN IMLTKSGHMFHIDFGKFLGHAQTFGGIK--RDRAPFIFTSEMEYFITEG--GK----NPQ HFQDFV---------------ELCCRAYNIIRKHSQLLLNLLEMMLYA-GLPELSGIQDL KYVY--NN-LRP-QD-TDLEATSHFTKKIKESL-ECFPVKLNNLIHTLAQMSAIS-PAK- STSQTFPQESCLLSTTRLIQTATILGFSKK----SSNLYLIQVTHSNNE--TSLIEKSFD QFSKLHSQLQKQFASLTLPEFPHWWHLPFT---NSDHKRFGDLNHYMEQILNGSCEVTNS D-----------CVLSFFLSEAVQQTVEESSLVYLG-EK------------FPDK-KPKV QLVISYEDVKLTILVKYMKNIH-LPDGSAPSAHVEFYLLPYPSEVRRRKTKSVPKCTDPT YNEI--VVYDEVT--ELQGHVLMLIVKSKTV------FVGAINIQLCSVPLDEE--KWYP LGNSII--- >H_sapiens_ENSP00000266497 -------------------MAYSWQTDPNPNESHEKQYEHQEFLFVNQPHSSSQVS---- ------------------------------------------------------------ -------------------------------------------------LGFDQIVDEIS GKIPHYESEIDENTFFVPTAPKWDSTGHSLNEAHQ------------------------- ------------------ISLNEFTSKSRELSWHQVSKAPAIGFSPSVLP---------- ----K---PQNTNKECSWGSPIGKHHGAD------------------------------- ------------------DSRFSILAPSFTSLDKINL-----EKELENENHNYHIGFESS IPPTNSSFSSDFM----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PKEENKRSGHVNIVEPSLM-------------------------------------- -----LLK---------GSLQPGMWESTWQKNIESIGCSI-------QLVEVPQSSNTSL ASFCNKVKK---IRERYHAADVNF---NSGKIWSTTTAFPY-QLFSKT-KFNIHI----- -----------------------FIDNSTQPLHFMPCANYLVKDLIAEILHFCTND--Q- ------------LL-PKDHILSVCGSEEFLQN-D-HCLGS-HK--MF-Q----KDKS-VI QLHLQK--SREA--PGK-----LSRKHEEDHSQFYLNQLL---EFMHIWKVS-RQCLLTL IRKYDFHLKYLLKTQEN---V--------------------YNIIEEVKKICSVLGC-VE TKQITDAV--NELSL---ILQRKGENF-------------------------YQS-SET- -------------------SAKGLIEKVTTELSTSIYQLINVYCNSFY-ADFQP------ -VNVPR----CTSYL--------NPGLPSH-LSFTVYAAHN---------IPETWVHR-- -----------------------------------------------IN-F-PLEIKSLP RESMLTVKLFGI--------------------------ACAT-------NNANLLAWTCL PLFPKE------------------KSILGSMLFSMTLQSEPPV------EMITPGVWDVS QPSP------VTLQ-----IDFPATGW---E--YMKPDS--------EEN---------- ------------------------------------------------------------ -------RSNLEEP---LKEC----IKHIARLS----QKQTPLLLSEEKKRYLWFY-RFY C-NNENCSLPLV-LGSAPGWDERTVS---EMH---TILRRW-----TFSQPLEALGLLTS SFPDQEIRKVAVQQL-DN-LLNDELLEYLPQLVQAVKFEWNLESPLVQLLLHRSLQ--SI QVAHRLYWLLKNAE-N------E-----------------------AYFKSWYQKLLAAL QFCAGKALNDEFSKEQKLIKILGDIGERVKSA--S---DHQRQ----------------- EVLKKEIGRLEE-FF----QDVNTCHLPLNPALCIKGI-D-HDACSYFTSNALPLKITFI NANPM-----GKNI----SIIF--KAGD--DL-RQDMLVLQLIQVMDNIWLQEGLDMQMI IYRCLSTGKDQ---GLVQMVPDAVTLAKIHR---HSGLI-GPLKENTI--KKWFSQHNHL KA-------------------------DYEKALRNFFY-SCAGWCVVTFILGVCDRHNDN IMLTKSGHMFHIDFGKFLGHAQTFGGIK--RDRAPFIFTSEMEYFITEG--GK----NPQ HFQDFV---------------ELCCRAYNIIRKHSQLLLNLLEMMLYA-GLPELSGIQDL KYVY--NN-LRP-QD-TDLEATSHFTKKIKESL-ECFPVKLNNLIHTLAQMSAIS-PAK- STSQTFPQESCLLSTTRSIERATILGFSKK----SSNLYLIQVTHSNNE--TSLTEKSFE QFSKLHSQLQKQFASLTLPEFPHWWHLPFT---NSDHRRFRDLNHYMEQILNVSHEVTNS D-----------CVLSFFLSEAVQQTVEESSPVYLGKKK------------FPDK-KPKV QLVISYEDVKLTILVKHMKNIH-LPDGSAPSAHVEFYLLPYPSEVRRRKTKSVPKCTDPT YNEI--VVYDEVT--ELQGHVLMLIVKSKTV------FVGAINIRLCSVPLDKE--KWYP LGNSII--- >C_familiaris_ENSCAFP00000018530 -------------------MAYCWKTDLNTSESHQEQHEHQEFHSVNQFLSPNQVS---- ------------------------------------------------------------ -------------------------------------------------LGFDQLVDEIS NKVPLYQTDIEENTIFVPSAPTWDSRRHSLDETHQ------------------------- ------------------ISLNELTAKSSELSCHRIRKTPVIGFRSSVLQ---------- ----N---PENTNKGSSWGNPTGKYQGAD------------------------------- ------------------DYRFNILASSSTSLHEINS-----QRELENENPNYHIGFESS IPSMYPSFSTDFM----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PKEENERSRNMNTVQHSLM-------------------------------------- -----LFE---------GSFLPRARESTWPKIIELTGCSS-------QLVEVPQGTNKDL ASFCNKVKK---IREMYHAADINS---NSGKIWSTTTAFPY-QLFSNT-KFNINI----- -----------------------CIDNSTQLLHFMPNANYLVKDLIAEILHFCTND--Q- ------------LF-PKDHLLSVCGYEEFLQN-D-YSLGC-HK--IF-Q----KDKS-VI QLNLQK--NGEV--PGK-----LSRKHEDDHSQFYLKQLL---EFMHIWKVS-RQCLSTV IKKYDFHLKCLLKTQQH---V--------------------DNIIEDVKNICSVLGC-VE TKQITDAV--NELNQ---ILQRKTENF-------------------------HQN-SET- -------------------SAKGLIERVTTALSRSIYQLISVYCCSFY-ADFQP------ -LNVPN----DISYL--------NPGLHSH-LSFTVYAVHN---------IPETWVHR-- -----------------------------------------------IN-F-PLEIKSLP RESMLTIRLFGI--------------------------VCAT-------NNANLLAWTCL PLFPKD------------------KSILGSVLSSMTLQNEPPI------EMIVPGVWDIS QPSS------VILQ-----IDFPATEL---E--YMKFDS--------EEN---------- ------------------------------------------------------------ -------RSNLEEP---PKEC----LKHIARLS----QKQSPLLLSEEKKRYLWFY-RFY C-NNENCSLPLV-LGSAPGWDVRTVS---EIH---TILRRW-----QFSCPLEALGLLTS SFPDQEIRKVAVRQL-DN-LLNDELLEYLPQLVQAVKFEWNLESPLVQLLLHRSLQ--SI QIAHRLYWLLKDAQ-N------E-----------------------TYFKSWYQKLLAAL QFCSGKALSDEFSKEKKLIKILGDIGEKVKSA--S---DPQRQ----------------- EVLKKEIGRLEE-FF----QCIKTCHLPLNPALCIKGI-D-RDACSYFTSHALPLKITFI NANPM-----GKNI----SIIF--KAGD--DL-RQDMLVLQIIQVMDNIWLQEGLDMQMI IYRCLSTGKGQ---GLVQMVPDAITLAKIHR---HSGLI-GPLKENTI--KKWFSQHNHL KA-------------------------DYEKALRNFFY-SCAGWCVVTFILGVCDRHNDN IMLTKSGHMFHIDFGKFLGHAQTFGGIK--RDRAPFIFTSEMEYFITEG--GK----NPQ HFQDFV---------------ELCCQAYNIVRRHSRLLLNLLEMMLHA-GLPELGGIQDL KYVY--NN-LRP-QD-TDLEATSHFTKKIKESL-ECFPVKLNNLIHTLAQMTSIN-PAK- SASQNFSQESCMLNATRSIQRATILGFSKK----TSHLYLIQVTHSNNE--TSFSEKSFD QFSKLHSELQKQFASLTLPEFPHWWHLPFT---NSNHKRFRDLNHYMEQILNGSYEVANS D-----------CVLSFFLSEPVQQTIEESSLLDLG-EK------------FPDK-MPMV QLVISHEDAKLTILVKHMKNIH-LPDGSAPSAHVEFYLLPYPSEVRRRKTKSVPKCTDPT YNEI--VVYNEVT--ELRGHVLMLIVKSKTV------FVGAINIQLYSVPLNEE--KWYP LGNCIIPFL