>H_sapiens_ENSP00000265563 -MS-----HIQIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------PGLTELLQGYTVEVLRQQP------------PDLVEFAVEYFTRLRE ARAPASVLPAATPR--------------------QSLGHPPPEPG--------------- ------------------------------------------------------------ -----------------------------------------PDRVADAKGDSESE----- --------------------------------------EDEDLE---------------- ---------VPVPSRF-NRRVS--VCAETYNPDEE-EED----TDPR------------- ------------------VIHPKTDEQRCRLQEACKDILLFKN-LDQEQ-LSQVLDAMFE RIVK----ADEHVIDQG--DDGDNFY--VI-E--RGTYDILV-TK--DNQTRSVGQYDNR GSFGELALMYNTPRAATI--VATSE-GSLWGLDRVTFRRIIV--KNNAKKRKMFESFI-- ES-VPLL-KSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRT KSNKDGGNQEVEIARCHKGQYF-G-ELALVT--NKPRAASAY--AVGD-VKCLVMDVQAF ERLLGPCMDIM--------KRNISHYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVKMF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSVDLGNLGQ-------------------------- >P_troglodytes_ENSPTRP00000025724 -MS-----HIQIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------PGLTELLQGYTVEVLRQQP------------PDLVEFAVEYFTRLRE ARAPASVLPAATPR--------------------QSLGHPPPEPG--------------- ------------------------------------------------------------ -----------------------------------------PDRVADTKGDSESE----- --------------------------------------EDEDLE---------------- ---------VPVPSRF-NRRVS--VCAETYNPDEE-EED----TDPR------------- ------------------VIHPKTDEQRCRLQEACKDILLFKN-LDQEQ-LSQVLDAMFE RIVK----ADEHVIDQG--DDGDNFY--VI-E--RGTYDILV-TK--DDQTRSVGQYDNR GSFGELALMYNTPRAATI--VATSE-GSLWGLDRVTFRRIIV--KNNAKKRKMFESFI-- ES-VPLL-KSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRT KSNKDGGNQEVEIARCHKGQYF-G-ELALVT--NKPRAASAY--AVGD-VKCL------- -RLLGPCMDIM--------KRNISHYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVKMF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSVDLGNLGQ-------------------------- >M_mulatta_ENSMMUP00000000105 -MS-----HIQIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------PGLTELLQGYTVEVLRQQP------------PDLVEFAVDYFTRLRE ARAPASVLPAATPR--------------------QSPGHPPPEPG--------------- ------------------------------------------------------------ -----------------------------------------PDRVADAKGDSESE----- --------------------------------------EDEDLE---------------- ---------GAIPSRF-VLKCS--VCAETYNPDEE-EED----TDPR------------- ------------------VIHPKTDEQRCRLQEACKDILLFKN-LDQEQ-LSQVLDAMFE RIVK----ADEHVIDQG--DDGDNFY--VI-E--RGTYDILV-TK--DNQTRSVGQYDNR GSFGELALMYNTPRAATI--VATSE-GSLWGLDRVTFRRIIV--KNNAKKRKMFESFI-- ES-VPLL-KSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSKT KSNKDGGNQEVEIARCH-GQYF-G-ELALVT--NNPRAASAY--AVGD-VKCLVMDVQAF ERLLGPCMDIM--------KRNISHYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVKMF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSMDLGNLGQ-------------------------- >P_pygmaeus_ENSPPYP00000015541 -MS-----HIQIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------PGLTELLQGYTVEVLRQQP------------PDLVEFAVDYFTRLRE ARAPASVLPAATPR--------------------QSLRHSTLEPG--------------- ------------------------------------------------------------ -----------------------------------------PDRVADAKGDSESE----- --------------------------------------EDEDLE---------------- ---------VPVPSRF-NRRVS--VCAETYNPDEE-EED----TDPR------------- ------------------VIHPKTDEQRCRLQEACKDILLFKN-LDQEQ-LSQVLDAMFE RIVK----ADEHVIDQG--DDGDNFY--VI-E--RGTYDILV-TK--DNQTRSVGQYDNR GSFGELALMYNTPRAATI--VATSE-GSLWGLDRVTFRRIIV--KNNAKKRKMFESFI-- ES-VPLL-KSLEVSERMKIVDVIGEKIYKDGERIITQ----------------------T KSNKDGGNQEVEIARCHKGQYF-G-ELALVT--NKPRAASAY--AVGD-VKCLVMDVQAF ERLLGPCMDIM--------KRNISHYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVKMF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSVDLGNLGQ-------------------------- >B_taurus_ENSBTAP00000018886 -MS-----HIQIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------PGLTELLQGYTVEVLRQRP------------PDLVDFAVDYFTRLRE ARSRASTPPAAPPS-----------------------GSQDFDPG--------------- ------------------------------------------------------------ -----------------------------------------AGLVADAVADSESE----- --------------------------------------DEEDLD---------------- ---------VPIPGRF-DRRVS--VCAETYNPDEE-EED----TDPR------------- ------------------VIHPKTDQQRCRLQEACKDILLFKN-LDPEQ-LSQVLDAMFE RTVK----VDEHVIDQG--DDGDNFY--VI-E--RGTYDILV-TK--DNQTRSVGQYDNH GSFGELALMYNTPRAATI--VATSE-GSLWGLDRVTFRRIIV--KNNAKKRKMFESFI-- ES-VPLL-KSLEVSERMKIVDVIGEKVYKDGERIITQGEKADSFYIIESGEVSILIKSKT KVNKDGENQEVEIARCHKGQYF-G-ELALVT--NKPRAASAY--AVGD-VKCLVMDVQAF ERLLGPCMDIM--------KRNISHYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVKMF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSMDLIDPGQ-------------------------- >C_familiaris_ENSCAFP00000017836 -MS-----HIQIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------PGLTELLQGYTVEVLRQQP------------PDLVDFAVDYFTRLRE ARLQASSPPAAPPS-----------------------GSQGLEPS--------------- ------------------------------------------------------------ -----------------------------------------PGLVADAKADSESE----- --------------------------------------DDEDLD---------------- ---------VPIPSRF-DRRVSDLVCAETYNPDEE-EED----TDPR------------- ------------------VIHPKTDQQRCRLQEACKDILLFKN-LDQEQ-LSQVLDAMFE RTVK----VDEHVIDQG--DDGDNFY--VI-E--RGTYDILV-TK--DNQTRSVGQYDNR GSFGELALMYNTPRAATI--IATSE-GSLWGLDRVTFRRIIV--KNNAKKRRMFESFI-- ES-VPLL-KSLEMSERMKIVDVIGEKAYKDGERIITQGEKADSFYIIESGEVSILIRSKT KANKDGGNQEVEIARCHKGQYF-G-ELALVT--NKPRAASAY--AVGD-VKCLVMDVQAF ERLLGPCMDIM--------KRNISHYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVKMF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSMDLIDPGQ-------------------------- >M_musculus_ENSMUSP00000035220 -MS-----HIQIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AGLTELLQGYTVEVLRQQP------------PDLVDFAVEYFTRLRE ARRQESDTFIVSPT-----------------------TFHTQESS--------------- ------------------------------------------------------------ -----------------------------------------AVPVIEEDGESDSDS---- --------------------------------------EDADLE---------------- ---------VPVPSKF-TRRVS--VCAETFNPDEE-EED----NDPR------------- ------------------VVHPKTDEQRCRLQEACKDILLFKN-LDQEQ-LSQVLDAMFE KIVK----TDEHVIDQG--DDGDNFY--VI-E--RGTYDILV-TK--DNQTRSVGQYDNR GSFGELALMYNTPRAATI--IATSE-GSLWGLDRVTFRRIIV--KNNAKKRKMFESFI-- ES-VPLF-KSLEMSERMKIVDVIGEKIYKDGERIIAQGEKADSFYIIESGEVSILIRSKT KSNKNGGNQEVEIAHCHKGQYF-G-ELALVT--NKPRAASAY--AVGD-VKCLVMDVQAF ERLLGPCMDIM--------KRNISHYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVKMF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSNLDLMDPGQ-------------------------- >R_norvegicus_ENSRNOP00000027552 -MS-----HIQIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------PGLTELLQGYTVEVLRQQP------------PDLVDFAVEYFTRLRE ARRQESDSFIAPPT-----------------------TFHAQESS--------------- ------------------------------------------------------------ -----------------------------------------GVPVIEEDGESESDS---- --------------------------------------DDEDLE---------------- ---------VPIPSKF-TRRVS--VCAETFNPD-E-EED----NDPR------------- ------------------VVHPKTDEQRCRLQEACKDILLFKN-LDQEQ-LSQVLDAMFE KIVK----TDEHVIDQG--DDGDNFY--VI-E--RGTYDILV-TK--DNQTRSVGQYDNR GSFGELALMYNTPRAATI--VATSD-GSLWGLDRVTFRRIIV--KNNAKKRKMFESFI-- ES-VPLF-KSLEMSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSKT KTNKNGGNQEVEIAHCHKGQYF-G-ELALVT--NKPRAASAY--AVGD-VKCLVMDVQAF ERLLGPCMDIM--------KRNISHYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVKMF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSNLDLLDPGQ-------------------------- >T_guttata_ENSTGUP00000009429 -MS------IEIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------PGLTELLQGYTVEVLRHRP------------SDLLGFAAEYFARLRD ARDQEAGGG---------------------------RRGRFPAGQ--------------- ------------------------------------------------------------ ---------------------GGQRAGIEWGRGSAG-----SRSPAPPLPGRCRSAPGAP HA------------------------------------PSLGPE---------------- ---------SPVVNRY-NRRVS--VCAEAFNPDEE-EED----TEQR------------- ------------------VVHPKTDEQRCRLQEACKDILLFKN-LDQEQ-LSQVLDAMFE RKVK----PQEHVIDQG--DDGDNFY--VV-E--RGVYDIVV-AK--DNQSRCVGRYDNH GSFGELALMYNTPRAATI--VATTE-GALWGLDRVTFRRIIL--KNNAKKRKTYELFI-- ES-VPLL-KSLEPSERMKIVDVIGEKVYQDGERIISQGDKADCFYIVESGEVKILIKSKG NSVKE-ANQEVEIARCHRGQYF-G-ELALVT--NKPRAASAY--AVGE-VKCLVMDVQAF ERLLGPCMDIM--------KRNITHYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVAMF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSMDLMDPGN-------------------------- >G_gallus_ENSGALP00000011344 -MS------IEIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------PGLTELLQGYTVEVLRHRP------------ADLVGFAADYFTRLRD AREQEATGD--------------------------GRRVISFDGE--------------- ------------------------------------------------------------ ---------------------PMQ-----------------TESNGEEEPERGDEE---- --------------------------------------SDSDFE---------------- ---------PPVINRY-NRRVS--VCAEAFNPDEE-EED----TEQR------------- ------------------IVHPKTDEQRCRLQEACKDILLFKN-LDQEQ-LSQVLDAMFE RKVK----PHEHVIDQG--DDGDNFY--VI-E--EGLYDIVV-AK--DNQARCVGRYDNH GSFGELALMYNTPRAATI--VATTE-GALWGLDRVTFRRIIL--KNNAKKRKTYELFI-- ES-VPLL-KSLEASERMKIVDVIGEKVYQDGERIISQGDKADCFYIVESGEVKIMIKSKT MMSKE-ANQEVEIARCHRGQYF-G-ELALVT--NKPRAASAY--AVGE-VKCLVMDVQAF ERLLGPCMDIM--------KRNITHYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVAMF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSMDLMDPGN-------------------------- >M_domestica_ENSMODP00000016745 --------HIEIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------PGLTELLQGYTVEVLRNHP------------EDLVDFAVDYFTRLRE NRRLGEDGEKDEGRGDEEDE----------HAGPSSHPDLPFPLH--------------- ------------------------------------------------------------ ---------------------------------------------SSEPGKPASL----- --------------------------------------CQFFLS---------------- ---------APVINRY-NRRVS--VCAESFNPDE--EDD----TEPK------------- ------------------VIHPKSDEQRSRLQEACKDILLFKN-LDQEQ-LSEVLDAMFE RIVV----SEEHVIDQG--DDGDNFY--VI-E--RGKYDILV-TK--ENQSFRVGQYDNR GSFGELALMYNTPRAATI--VAITE-GSLWGLDRITFRRIIL--KNNAKKRKMFESFI-- ES-VPLL-KSLEVSERMKIVDVIGEKNYKDGEQIIAQGDKAESFYIVESGEVKILIKSKT NKD---TEDEVEIARCQKGQYF-G-ELALVT--NKPRAASAY--AVGD-VKCLVMDVQAF ERLLGPCMDIM--------KRNISNYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVKMF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSVDLSDPGN-------------------------- >X_tropicalis_ENSXETP00000020557 -MS------IEIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------PGLTDLLQGYTVEVLRQKP------------PDLVEFAIQYFTRLKE KQLQDGAGAGSLR---------------------PHARVVNFDGE--------------- ------------------------------------------------------------ ---------------------PMQ-----------------TESNGDEEEDEEDD----- --------------------------------------DDSDFE---------------- ---------PPVINRY-SRRVS--VCAEAYNPDEE-DED----TEPR------------- ------------------VVRPKTDEQRCRLQEACKDILLFKN-LDQEQ-LSQVLDAMFE MRVK----PQEHVIDQG--DDGDNFY--VV-E--RGQYDIFV-ER--DGQSRCVGRYDNH GSFGELALMYNTPRAATI--VATSE-GALWGLDRVTFRRIIL--KNNAKKRKTYEIFI-- ES-VPVL-KFLELSERMKIVDVIAARVYKDGDRIIAQGDKADCFFIVESGEVKIMMKSKT KTGQE-SNQEVEIARCKSGQYF-G-ELALVT--NKPRAASAY--AVGD-VKCLIMDVQAF ERLLGPCMDIM--------KRNITHYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVALF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSMDLRDPGK-------------------------- >G_gorilla_ENSGGOP00000008988 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------PVPSRF-NRRVS--VCAETYNPDEE-EED----TDPR------------- ------------------XXXXXXXXXXXXXXXXXXXXXXXXX-XXQEQ-LSQVLDAMFE RIVK----ADEHVIDQG--DDGDNFY--VI-E--RGTYDILV-TK--DNQTRSVGQYDNR GSFGELALMYNTPRAATI--VATSE-GSLWGLDRVTFRRIIV--KNNAKKRKMFESFI-- ES-VPLL-KSLEVSEXMKIVDVIGEKIYKDGERIITQXXXADSFYIIESGEVSILIRSRT KSNKDGGNQEVEIARCHKGQYF-G-ELALVT--NKPRAASAY--AVGD-VTCLVMDVQAF ERLLGPCMDIM--------KRNISHYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVKMF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSVDLGNLGQ-------------------------- >O_latipes_ENSORLP00000003826 -MS------IEIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------VGLTELLQGYTVEVLRQRP------------SDLVEFAVQYFTRLRD SRARQNAILISSPQRFHIKE----------STGGRISIEWDLNSK--------------- ------------------------------------------------------------ ---------------------QKY------------------------------------ --------------------------------------ETKNQN---------------- ---------APPPSRF-NRRVS--VCAEAFNPDDD-DED----TEPR------------- ------------------VVHPKTDEQRCRLQEACRDILLFKT-LDQEQ-FSQVLDAMFE LKVQ----PQEHVIDQG--HDGDNFY--VI-E--RGIYDIVV-S------GKCVGQYNNK GSFGELALMYNTPRAATI--IATQE-GALWGLDRATFRRLIV--KNNAKKRRMYETFI-- ES-VPLL-KTLEPNERMKIVDVLGMKQFLDGERIIAQGEKAECFYIVESGEVKIMMKSKT KADHA-DNAEVEITRCSRGQYF-G-ELALVT--NKPRAASAY--AVGD-VKCLVIDVQAF ERLLGSCKEIM--------KRNISHYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVALF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSMDLRD----------------------------- >T_rubripes_ENSTRUP00000023587 -MS------IEIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------VGLTELLQGFTVEVLRQRP------------SDLVDFAVQYFTRLRD TKSQDGS-----------------------GAAGKTGKGVMFDGE--------------- ------------------------------------------------------------ ---------------------PMQ---------------------TESNGEDDED----- --------------------------------------DDSDFELLKSLHRPRNDEKKHK KLPCSYTFRAPPPSRF-NRRVS--VCAEAFNPDED-DED----SEPR------------- ------------------VVHPKTDVQRCRLQEACRDILLFKT-LDQEQ-FSQVLDAMFE SRVQ----AQEHVIDQG--DDGDNFY--VI-E--RGVFDIVV-S------GNCVGQYNNK GSFGELALMYNTPRAATI--IATQE-GALWGLDRATFRRLIV--KNNAKKRRMYETFI-- ES-VPLL-KSLEVTERMKLVDVLGAKQFSDSERIITQGDKADCFYIVESGEVKIMMKSKT KAGHA-DNAEVEITRCSRGQYF-G-ELALVT--NKPRAASAY--AVGD-VKCLVVDVQAF ERLLGSCKEIM--------KRNIAHYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVALF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSMDLRD----------------------------- >M_mulatta_ENSMMUP00000020202 --X------IEIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AGLTELLQGFTVEVLRHQP------------ADLLEFALQHFTRLQQ ENERKGTARFGHEGRTWGDAGA-SA---AAVGGGTPSKGVNFAEE--------------- ------------------------------------------------------------ ---------------------PMH-----------------SDSEDG---EEEEAAPA-- --------------------------------------DAGAFN---------------- ---------APVINRF-TRRAS--VCAEAYNPDEE-EDD----AESR------------- ------------------IIHPKTDDQRNRLQEACKDILLFKN-LDPEQ-MSQVLDAMFE KLVK----DGEHVIDQG--DDGDNFY--VI-D--RGTYDIYV-KC--DGVGRCVGNYDNR GSFGELALMYNTPRAATI--TATSP-GALWGLDRVTFRRIIV--KNNAKKRKMYESFI-- ES-LPFL-KSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKITMKRKG KSEVE-ENGAVEIARCSRGQYF-G-ELALVT--NKPRAASAH--AIGT-VKCLAMDVQAF ERLLGPCMEIM--------KRNIATYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVALF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GTNMDIVEPTA-------------------------- >P_troglodytes_ENSPTRP00000047706 ---------IEIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AGLTELLQGFTVEVLRHQP------------ADLLEFALQHFTRLQQ ENERKGTARFGHEGRTWGDLGA-AA------GGGTPSKGVNFAEE--------------- ------------------------------------------------------------ ---------------------PMH-----------------SDSEDG---EEEEAAPA-- --------------------------------------DAGAFN---------------- ---------APVINRF-TRRAS--VCAEAYNPDEE-EDD----AESR------------- ------------------IIHPKTDDQRNRLQEACKDILLFKN-LDPEQ-MSQVLDAMFE KLVK----DGEHVIDQG--DDGDNFY--VI-D--RGTFDIYV-KC--DGVGRCVGNYDNR GSFGELALMYNTPRAATI--TATSP-GALWGLDRVTFRRIIV--KNNAKKRKMYESFI-- ES-LPFL-KSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKITMKRKG KSEVE-ENGAVEIARCSRGQYF-G-ELALVT--NKPRAASAH--AIGT-VKCLAMDVQAF ERLLGPCMEIM--------KRNIATYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVALF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GTNMDIVEPTA-------------------------- >H_sapiens_ENSP00000265717 -MS------IEIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AGLTELLQGFTVEVLRHQP------------ADLLEFALQHFTRLQQ ENERKGTARFGHEGRTWGDLGA-AA------GGGTPSKGVNFAEE--------------- ------------------------------------------------------------ ---------------------PMQ-----------------SDSEDG---EEEEAAPA-- --------------------------------------DAGAFN---------------- ---------APVINRF-TRRAS--VCAEAYNPDEE-EDD----AESR------------- ------------------IIHPKTDDQRNRLQEACKDILLFKN-LDPEQ-MSQVLDAMFE KLVK----DGEHVIDQG--DDGDNFY--VI-D--RGTFDIYV-KC--DGVGRCVGNYDNR GSFGELALMYNTPRAATI--TATSP-GALWGLDRVTFRRIIV--KNNAKKRKMYESFI-- ES-LPFL-KSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKITMKRKG KSEVE-ENGAVEIARCSRGQYF-G-ELALVT--NKPRAASAH--AIGT-VKCLAMDVQAF ERLLGPCMEIM--------KRNIATYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVALF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GTNMDIVEPTA-------------------------- >B_taurus_ENSBTAP00000019916 -MS------IEIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AGLTELLQGFTVEVLRHQP------------ADLLEFALQHFTRLQE ENERKGAARFGHEGRTWGDAGA-AS------GGGTPSKGVNFAEE--------------- ------------------------------------------------------------ ---------------------PRH-----------------SDSENG---EEEEEEAA-- --------------------------------------DAGAFN---------------- ---------APVINRF-TRRAS--VCAEAYNPDEE-EDD----AESR------------- ------------------IIHPKTDDQRNRLQEACKDILLFKN-LDPEQ-MSQVLDAMFE KLVK----EGEHVIDQG--DDGDNFY--VI-D--RGTFDIYV-KC--DGVGRCVGNYDNR GSFGELALMYNTPRAATI--TATSP-GALWGLDRVTFRRIIV--KNNAKKRKMYESFI-- ES-LPFL-KSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKG KSEVE-ENGAVEIARCSRGQYF-G-ELALVT--NKPRAASAH--AIGT-VKCLAMDVQAF ERLLGPCMEIM--------KRNIATYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVALF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GTNMDIVEPTA-------------------------- >C_familiaris_ENSCAFP00000005888 -MS------IEIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AGLTELLQGFTVEVLRHQP------------ADLLDFALQHFTRLQQ ENERRGAARFGHEARTWGDAGA-AA------GGGTPSKGVNFAEE--------------- ------------------------------------------------------------ ---------------------PAR-----------------TDSEDA----EEEEEAA-- --------------------------------------DAGAFN---------------- ---------APVINRF-TRRAS--VCAEAYNPDEE-EDD----AESR------------- ------------------IIHPKTDDQRNRLQEACKDILLFKN-LDPEQ-MSQVLDAMFE KLVK----EGEHVIDQG--DDGDNFY--VI-D--RGTFDIYV-KC--DGVGRCVGNYDNR GSFGELALMYNTPRAATI--TATSP-GALWGLDRVTFRRIIV--KNNAKKRKMYESFI-- ES-LPFL-KSLEVSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKITMKRKG KSEVE-EDGAVEIARCSRGQYF-G-ELALVT--NKPRAASAH--AIGT-VKCLAMDVQAF ERLLGPCMEIM--------KRNIATYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVALF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GTNMDIVEPTA-------------------------- >G_aculeatus_ENSGACP00000007645 -MS------IEIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------VGLTELLQGYTVEVLRQRP------------SDLVDFAVQYFSRLRD TRSQDGD-----------------------TAGGKTAKDSDFERG--------------- ------------------------------------------------------------ ---------------------AFL-----------------TVKNCSADGEVRD------ --------------------------------------GPQVDR---------------- ---------APPPSRF-SRRVS--VCAEAFNPDDD-DED----TEPR------------- ------------------VVHPKTDEQRCRLQEACRDILLFKT-LDQEQ-FSEVLDAMFE LRVQ----PLEHVIDQG--DDGDNFY--VI-E--RGVYDIMV-------MGTTVGQYNNK GSFGELALMYNTPRAATI--AATEE-GALWGLDRATFRRLIV--KNNAKKRRVYEAFI-- ES-VPLL-KSLEANERMKIVDVLGSKQFPDGERIITQGDKAECFYIVESGEVKIMMKSKT KADHA-DNAEVEITRCSRGHYF-G-ELALVT--NKPRAASAY--AVGD-VKCVVIDIQAF ERLLGSCKEIM--------KRNIAHYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVALF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSMDLRD----------------------------- >M_musculus_ENSMUSP00000003079 -MS------IEIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AGLTELLQGFTVEVLRHQP------------ADLLEFALQHFTRLQQ ENERKGAARFGHEGRTWGDAGA-AA------GGGIPSKGVNFAEE--------------- ------------------------------------------------------------ ---------------------PMR-----------------SDSENG-----EEEEAA-- --------------------------------------EAGAFN---------------- ---------APVINRF-TRRAS--VCAEAYNPDEE-EDD----AESR------------- ------------------IIHPKTDDQRNRLQEACKDILLFKN-LDPEQ-MSQVLDAMFE KLVK----EGEHVIDQG--DDGDNFY--VI-D--RGTFDIYV-KC--DGVGRCVGNYDNR GSFGELALMYNTPRAATI--TATSP-GALWGLDRVTFRRIIV--KNNAKKRKMYESFI-- ES-LPFL-KSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKG KSEVE-ENGAVEIARCFRGQYF-G-ELALVT--NKPRAASAH--AIGT-VKCLAMDVQAF ERLLGPCMEIM--------KRNIATYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVALF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GTNMDIVEPTA-------------------------- >R_norvegicus_ENSRNOP00000012415 -MS------IEIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AGLTELLQGFTVEVLRHQP------------ADLLEFALQHFTRLQQ ENERKGAARFGHEGRTWGDAGA-AA------GGGTPSKGVNFAEE--------------- ------------------------------------------------------------ ---------------------PMR-----------------SDSENG-----EEEEAA-- --------------------------------------EAGAFN---------------- ---------APVINRF-TRRAS--VCAEAYNPDEE-EDD----AESR------------- ------------------IIHPKTDDQRNRLQEACKDILLFKN-LDPEQ-MSQVLDAMFE KLVK----EGEHVIDQG--DDGDNFY--VI-D--RGTFDIYV-KC--DGVGRCVGNYDNR GSFGELALMYNTPRAATI--TATSP-GALWGLDRVTFRRIIV--KNNAKKRKMYESFI-- ES-LPFL-KSLEVSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVRITMKRKG KSDIE-ENGAVEIARCLRGQYF-G-ELALVT--NKPRAASAH--AIGT-VKCLAMDVQAF ERLLGPCMEIM--------KRNIATYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVALF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GTNMDIVEPTA-------------------------- >A_carolinensis_ENSACAP00000011863 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------VCAEAYNPDEE-DED----TEPR------------- ------------------VVHPKTDEQRCRLQEACKDILLFKN-LDQEQ-LSQVLDAMFE RKVQ----PQEHVIDQG--DDGDNFY--VI-E--RGLYDIFV-AR--DGQTRCVGRYDNH GSFGELALMYNTPRAATI--VATTE-GALWGLDRVTFRRIIL--KNNAKKRKTYELFV-- ES-VPLL-KSLEPSERMKIVDVIGEKVFQDGERIICQGDKADSFYIVECGEVKILIKSKT ITGKD-ANQEIEIARCQKGQYF-G-ELALVT--NKPRAASAY--AVGE-VKCLVMDVQAF ERLLGPCMDIM--------KRNITHYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVALF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSMDLTNPGN-------------------------- >M_domestica_ENSMODP00000020466 --S------IEIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AGLTELLQSFTVEVLRHQP------------GDLLEFALQHFTRLQQ ENRYKG----GHGAVDRASAGAGAV------GGGTPSRGVNFADE--------------- ------------------------------------------------------------ ---------------------PVQ-----------------TESENG---EEEDDDEE-- --------------------------------------QQSGDT---------------- ---------APVLNRF-TRRAS--VCAEAYNPDEE-EDD----AESR------------- ------------------IIHPKTDDQRNRLQEACKDILLFKN-LDPEQ-MSQVLDAMFE KLVK----EGEHVIDQG--DDGDNFY--VI-D--RGTYDIYV-KC--DGVGKCIGNYDNR GSFGELALMYNTPRAATI--TATSP-GALWGLDRVTFRRIIV--KNNAKKRRMYESFI-- ES-LPFL-KSLEVSERLKVVDVIGTKVYKDGEQIIAQGDSADSFFIIESGEVKISMKRKN KQEVE-ENGAIEIARYSRGQYF-G-ELALVT--NKPRAASAH--AIGT-VKCLAMDVQAF ERLLGPCMEIM--------KRNIANYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVALF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GTNMDI------------------------------- >A_carolinensis_ENSACAP00000014732 -MS------ISVP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EGLTELLQGFTVEVLRSQP------------GDLLDFALQYFGRLKA EEEENGEADVGRLHA--ASPGT-PR------GKQAPRGGVNFAEE--------------- ------------------------------------------------------------ ---------------------PMQ-----------------TDSESG---EGDED--G-- --------------------------------------EAEGFP---------------- ---------APVINRF-TRRAS--VCAEAYNPDEE-EDD----ADSK------------- ------------------IIHPKTDDQRNRLQEACKDILLFKN-LDPEQ-MSQVLDAMFE KSVE----GGEHVIDQG--DDGDNFY--VI-D--WGTYDIYV-KC--EGVGRCVGTYDNR GSFGELALMYNTPRAATI--IATSP-GAVWGLDRVTFRRIIV--KNNAKKRRMYESFI-- ES-LPFL-KSLELSERLKVVDVIGTKIYKDGEQIIAQGDMADCFFIIESGEVKITMKRKG KQDVD-ENEAVEITRYTRGQYF-G-ELALVT--NKPRAASAF--ALGT-VKCLVRDVPAF ER-LGPCMEIM--------KRNIANYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVALF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GTNMDIADPSA-------------------------- >E_caballus_ENSECAP00000017462 -MA-----DQVKPISPLKNLLAGGFGGMCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSG TFDCFRKTLIREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKCPEDVLSYPQLF AAGMLSGVFTTGIMTPGERIKCLL-QIQASSG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------DTKY TGPLDCAKKVYQESGIRGIYKGTVLTLMRDVP------------ASGMYFMT--YEWLKN IFTPEGKSVNELSVPRILVAGGIAGIFNWAVAIPPDVLKSRFQTA--------------- ------------------------------------------------------------ ---------------------PPG---------------------------------KYP NGFKDVL-------------------------------RELIRD---------------- ---------EGVTSLY-KGFNA--VMIRAFPANAV-TPP----KVPY------------- ------------------SDF-------------------------PEQ-LSQVLDAMFE RTVK----VDEHVIDQG--DDGDNFY--VI-E--RGTYDILV-TK--DNQTRSVGQYDNH GSFGELALMYNTPRAATI--VATSE-GSLWGLDRVTFRRIIV--KNNAKKRKMFESFI-- ES-VPLL-KSLEVSERMKIVDVIGEKSYKDGERIITQGEKADSFYIIESGEVSILIKSKT KANKDGGNQEVEIARCHKGQYF-G-ELALVT--NKPRAASAY--AVGD-VKCLVMDVQAF ERLLGPCMDIM--------KRNISHYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVKMF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSLDLIDPGQ-------------------------- >D_rerio_ENSDARP00000048675 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------DLFL----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SVFLST---------------- ---------APPPSRF-NRRVS--VCAEAFNPDDD-EED----SEPR------------- ------------------VVHPKTDEQRCRLQEACKDILLFKA-LDQEQ-FSEVLDAMFE VLVQ----PQDHVIDQG--DDGDNFY--VI-E--RGVYDIVV-QK--DGVGCCVGQYNNK GSFGELALMYNTPRAATI--IAKDE-GALWGLDRATFRRLIV--KNNAKKRRMYECFI-- ES-IPLL-KSLELSERMKIVDVLGVKTFQDGERIIMQGDKADCFYIVESGEVKIMMKSKT KADRQ-DNAEVEIARCSRGQYF-G-ELALVT--NKPRAASAY--AIGD-VKCLVIDIQAF ERLLGPCKEIM--------KRNIAHYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVALF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSVDLRD----------------------------- >G_aculeatus_ENSGACP00000001531 -MS-----SVEIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AGLKELLQGYTVEVLRREP------------PDLVEFAVQHFTRILE GQKKNRGAKKRSTR--------------------PARKGVTFDTVSN------------- ------------------------------------------------------------ --------------------KPSK-----------------VDDD-----EEEEDTISDK NHTKDKE-------------------------------KLSSQK---------------- ---------QSTTSKY-NRRVS--VCAEAYNPDDDEDDD----AELR------------- ------------------IVYPKTDVQRRRLQDACRDILLFKT-LEQEQ-FSEVLDGMFE VLVK----PQEHIIDQG--ADGDNFY--VI-E--KGVYDILV-QK--GGVSVCVGKYDNK GSFGELALMYNTPRAATI--IATQE-GALWGLDRATFHRLIV--RNNAKKRRTYEAFI-- EC-VPLL-KSLELSERMKIVDVVGARVFKDGERLITQGEEADCFYVVESGEVKIMITSQA KAG---QQDEVEVARCSRGQYF-G-ELALVT--NKPRAASVY--AVGE-TKCLVIDIQAF ERLLGPCMDIM--------KRNISQYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQRVALM------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSVD-------------------------------- >O_latipes_ENSORLP00000023083 -MS-----KFEIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AGLKELLQGYTVEVLRRRP------------ANLAQFAVQHFTQVLE SQRNEQAAESHSTGP-----------------AEEEEDDDAFETA--------------- ------------------------------------------------------------ --------------------------------------------SNPSISDEDEE----- --------------------------------------EERNIV---------------- ---------KAKADRC-SRRVA--VCAETYNPDEDEDND----TEPQ------------- ------------------VVHPKTDEQRQRLQDACKDILLFKT-LAKEQ-FSEVLDAMFE VLVK----PEEHIIDQG--DDGDNFY--VI-E--KGVFDIYV-QK--DGLNVCVGKYNNK GSFGELALMYNTPRAATI--VAKQD-GALWALDRATFHRLIV--KNNAKKRRMYEAFI-- EC-VPLL-KSLELSERMKIVDVLGVRTFSDGERIITQGDKADCFFIVESGEVKIMIKSK- KAGQP-DGVEVEVARCSRGQYF-G-ELALVT--NKPRAATAY--AVGD-TKCLVIDIQAF ERLLGPCMDIM--------KRNISQYK--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------DQLMALF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------G------------------------------------ >T_nigroviridis_ENSTNIP00000014986 -MS------IEIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------VGLTELLQGFTVEVLRQRP------------SDLVDFAVHYFTRLRD TKSQDGA-----------------------GAGGKMGKGVMFDGE--------------- ------------------------------------------------------------ ---------------------PMQ---------------------TESNGEDDED----- --------------------------------------DDSDFE---------------- ---------PPPPSRF-NRRVS--VCAEAFNPDED-DED----SEPR------------- ------------------VVHPKTDEQRCRLQEACRDILLFKT-LDQEQ-FSQVLDAMFE SRVQ----PQEHVIDQG--DDGDNFY--VI-E--RGVFDIVV-S------GNCVGQYNNK GSFGELALMYNTPRAATI--VATQE-GALWGLDRATFRRLIV--KNNAKKRRMYETFI-- ES-VPLL-KSLEATERMKLVDVLGAKQFSDSERIITQ----------------------T KADHA-DNAEVEIARCSRGQYF-G-ELALVT--NKPRAA-AY--AVGD-VKCLVIDVQAF ERLLGSCKEII--------KRNIAHYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVALF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSMDL------------------------------- >G_aculeatus_ENSGACP00000013289 -MS------IEIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EGLTELLQSFTVEVLRNQP------------RDLLEFALQYFTQLKE RETTQASFGNDQ------------------NSAPRPVKAVNFIDE--------------- ------------------------------------------------------------ ---------------------AMQ-----------------MDSENGE--ELVDI----- --------------------------------------YTYASA---------------- ---------APVINRF-IRRAS--VCAEAFNPDDD-DED----KEPW------------- ------------------VIHPKTDDQRQRLQEACWDILLFKN-LDPEE-MSQVLDAMFE KFCT----EGEHIIDQD--DDGDNFY--VI-E--SGTFKIFV-KV--DGTDKLVGCYDNR GSFGELALMYNTPRAATI--IATSP-GALWCLDRLTFRRIIV--KNNAKKRRVYEAFI-- ET-LPLL-TSLELSERMKVVDVISTKTYSDSQQIIAQGDLADCFYIVESGQVRITMKRSR TKKDQ-EDEEMDIATCMRGQYF-G-ELALVT--NKPRAASAY--AVGS-VKCLAMDVQAF ERLLGPCMDIM--------KRNIANYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVTLF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSTGMEQQSA-------------------------- >O_latipes_ENSORLP00000005487 -MS------IEIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EGLTELLQSFTVEVLRNQP------------RDLLEFALQYFTQLKD NETKEAAFGNDQ------------------NSAPRSGKAVNFIDE--------------- ------------------------------------------------------------ ---------------------AMQ-----------------IDSENGE--EEEDDDDD-- --------------------------------------DDEEFI---------------- ---------APVINRF-IRRAS--VCAEAFNPDED-EED----KEPR------------- ------------------VTYPKTDEQRQRLQEACRDILLFKN-LDPEE-ISQVLDAMFE KFCT----EGEHIIDQD--DDGDNFY--VI-E--SGTFNIFV-KV--DGIEKLVGCYDNR GSFGELALMYNTPRAATI--IATSP-GALWCLDRLTFRRIIV--KNNAKKRRLYEAFI-- ET-LPLL-TSLETSERMKVVDVLSTRVYNDSQQIIAQGDLADCFYIVESGQVRITMKRSR TKKDQ-EEEEVEIATCTRGQYF-G-ELALVT--NKPRAASAY--AVGS-VKCLVMDVQAF ERLLGPCMDIM--------KRNIANYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLQSLF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSPEIEQPSA-------------------------- >X_tropicalis_ENSXETP00000013024 -MS------IEIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EGLTELLQSFTVEVLRKQP------------EDLLEFALQYFTQLKQ SKSQGGPLSHGMELPF------------------RLTKGVIFAEE--------------- ------------------------------------------------------------ ---------------------PMQ-----------------TDSENG---EEEEDDDE-- --------------------------------------EDFVGV---------------- ---------RPFVPAF-HMQG---IGFSTLFSQAV-TEL----KLPA------------- ------------------VIYPKTDDQRNRLQEACKDILLFKS-LDQEQ-MSQVLDAMFE KLVK----CGEHVIDQG--DDGDNFY--VI-D--RGTYDIFV-KS--DGVVRCVGAYDNR GSFGELALMYNTPRAATI--VATSV-GSIWGLDRATFRRIIV--KNNAKKKRMYENFI-- ES-LPFL-KSLEFSERLKVVDVIGTKTYYDGEQIIAQGDGADSFYIVESGEVRINMKSKS KPDAE-TNEAVEIARYTRGQYF-G-ELALVT--NKPRAASAY--AVGN-VKCLVMDVQAF ERLLGPCMEIM--------KRNIANYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVALF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GTNMDITDPST-------------------------- >T_nigroviridis_ENSTNIP00000019115 -MS------IEIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EGLTELLQSFTVEVLRNQP------------RDLLQFALQYFTQLKE AESKEAPFGNDQ------------------NSAPRSGKAVNFIDE--------------- ------------------------------------------------------------ ---------------------AMQ-----------------IDSENGE--DPNISPSE-- ----PWW-------------------------------KRGANS---------------- ---------APVINRF-SRRAS--VCAEAFNPDED-EEE----KEPL------------- ------------------VTHPKTDEQRQRLQEACRDILLFKN-LDPEE-MSQVLDAMFE KFCT----EGEHIIDQD--DDGDNFY--VI-E--SGTFSIFV-KT--DSTEKLVGCYDNR GSFGELALMYNTPRAATI--IATST-GALWCLDRLTFRRIIV--KNNAKKRKMYESFI-- ET-LPLL-TSLELSERMKVVDVISSKVFSDSQQIIVQGDLADCFYIVESGQVRITIKRGR TKKDP-EEEEVDIATLSRGQYF-G-ELALVT--NKPRAASAY--AVGS-VKCLVMDVKAF ERLLGPCMDIM--------KRNIANYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVTLF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSTAIEQRSQ-------------------------- >O_anatinus_ENSOANP00000005022 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------DGHM------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------EPEKGQRR-- --------------------------------------LPRMME---------------- ---------SPVINRF-TRRAS--VCAEAYNPDEE-EDD----AESR------------- ------------------IIHPKTDDQRTRLQEACKDILLFKN-LDPEQ-MSQVLDAMFE KLVK----EGEHVIDQG--DDGDNFY--VI-D--RGTFDIYV-KC--DGVGRCVGNYDNR GSFGELALMYNTPRAATI--TATSP-GALWGLDRVTFRRIIV--KNNAKKRRMYENFI-- ES-LPFL-KSLDVSERLKVVDVIGTKIYKDGEQIIAQGDLADSFFIVESGEVKITMKRKN KQEVE-ENDSVEIARYSRGQYF-G-ELALVT--NKPRAASAY--AIGT-VKCLAMDVQAF ERLLGPCMEIM--------KRNIANYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVALF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GTNMDIADP---------------------------- >T_guttata_ENSTGUP00000003190 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------FAEE--------------- ------------------------------------------------------------ ---------------------AML-----------------TDSESGE--FEQPSPPP-- --------------------------------------PPQQFP---------------- ---------APAVNRF-TRRAS--VCAEAYNPDEE-EDD----AESR------------- ------------------IIHPKTDDQRNRLQEACKDILLFKN-LDPEQ-MSQVLDAMFE KMVE----GGEHVIDQG--DDGDNFY--VI-D--KGTYDIYV-KC--DGVGRCVGTYDNR GCFGELALMYNTPRAATI--IATSP-GSIWGLDRVTFRRIIV--KNNAKKRRMYESFI-- ES-LPFL-KSLEMSERLKVVDVIGTKVYKDGEQIIAQGDLADSFFIVESGEVRIIMTRKG KQDLE-ENGAVEIARCSRGQYF-G-ELALVT--NKPRAASAF--ALGT-VKCLVMDVQAF ERLLGPCMEIL--------KRNIANYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVALF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GTNMDIADTSA-------------------------- >P_pygmaeus_ENSPPYP00000020060 -MS------IEIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AGLTELLQGFTVEVLRHQP------------ADLLEFALQHFTRLQQ ENERKGTARFGHEGRIWGDVGA-AA------GGGTPSKGVNFAEE--------------- ------------------------------------------------------------ ---------------------PMH-----------------SDSEDG---EEEEAAPA-- --------------------------------------DAGAFN---------------- ---------APVINRF-TRRAS--VCAEAYNPDEE-EDD----AESR------------- -----------------------------------------------EQ-MSQVLDAMFE KLVK----DGEHVIDQG--DDGDNFY--VI-D--RGTFDIYV-KC--DGVGRCVGNYDNR GSFGELALMYNTPRAATI--TATSP-GALWGLDRVTFRRIIV--KNNAKKRKMYESFI-- ES-LPFL-KSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKITMKRKG KSEVE-ENGAVEIARCSRGQYF-G-ELALVT--NKPRAASAH--AIGT-VKCLAMDVQAF ERLLGPCMEIM--------KRNIATYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVALF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GTNMDIVEPTA-------------------------- >G_gallus_ENSGALP00000013072 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EAYNPDEE-EDD----AETR------------- ------------------IIHPKTDDQRNRLQEACKDILLFKN-LDPEQ-MSQVLDAMFE KLVE----GGEHVIDQG--DDGDNFY--VI-D--RGTYDIYV-KC--DGVGRCVGTYDNR GSFGELALMYNTPRAATI--IATSP-GAIWGLDRVTFRRIIV--KNNAKKRRMYENFI-- ES-LPFL-KSLEVSERLKVVDVIGTKVYKDGEQIIAQGDMADSFFIVESGEVRIIMTK-- ------ENGAVEIARCSRGQYF-G-ELALVT--NKPRAASAF--ALGT-VKCLVMDVQAF ERLLGPCMEIL--------KRNIANYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVALF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GTNMDIADTS--------------------------- >D_rerio_ENSDARP00000006288 -MS------VPVP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AGLPELLRGFTLEVLRRQP------------ADLLEFSVRYFTGLRD TRSSTRSASSRS----------------------PVTRGEAFDRD--------------- ------------------------------------------------------------ ---------------------SAH--TDSSVEEEEKPEEEEEEEEKPEEEDEEEDDFP-- --------------------------------------DDFTFK---------------- ---------APPPSKC-NRRVS--VCAEPYNPDED-DDDGDEGSQLT------------- ------------------VLHQKTDEQRQRLQDACKHILLFKT-LEEDQ-LAEVLDSMFE VLVK----PGECIINQG--DDGDNFY--VI-E--RGVYEIVI-QQ--DGLQHSVGRYDHK GSFGELALMYNTPRAATI--RALQE-GALWALDRATFHRLIV--KNNAKKRRMYESFI-- EC-VPLL-KSLQLSERMKIVDVLGMRSFSDGERIIQQGDSADCFYIVESGEVRIMIRSKT RACQL-LQEEVEVARCSRGQYF-G-ELALVT--KRPRAASVY--AVGD-TRCLVIDVQAF ERLLGSCKQIL--------KRNITHYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------QQLVAVF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSVDLKH----------------------------- >D_rerio_ENSDARP00000046625 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------NDDD----- --------------------------------------DDNNYY---------------- ---------APVINRF-VRRAS--VCAEAYNPDED-EEE----REPR------------- ------------------VTYPKTDEQRQRLQEACKDILLFKN-LDQEQ-MSQVLDAMFE KVVV----SGEHIIDQD--DDGDNFY--VI-E--RGMFEILL-KA--DGTTRTVGSYDNR GSFGELALMYNTPRAATI--IATSP-GALWCLDRLTFRRIIV--KNNAKKRKMYEAFI-- GT-LPLL-TSLEVSERMKVVDVLSTKVYNGGEQIIAQGDLADCFYIVESGHVRITMKRSK SKNDT-EDEEVEIATCSRGQYF-G-ELALVT--NKPRAASAY--AMDS-VKCLVMDVQAF ERLLGPCMDIM--------KRNIANYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLITLF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSQIAIEEPNA-------------------------- >E_caballus_ENSECAP00000009806 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------IIHPKTDDQRNRLQEACKDILLFKN-LDPEQ-MSQVLDAMFE KLVN----EGEHVIDQG--DDGDNFY--VI-D--RGTFDIYV-KC--DGVGRCVGNYDNR GSFGELALMYNTPRAATI--TATSP-GALWGLDRVTFRRIIV--KNNAKKRKMYESFI-- ES-LPFL-KSLEVSERLKVVDVIGTKVYSDGEQIIAQGDLADSFFIVESGEVKITMKRKG KSEAE-ENGAVEIARCSRGQYF-G-ELALVT--NKPRAASAH--AIGT-VKCLAMDVQAF ERLLGPCMEIM--------KRNIATYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVALF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GTNMDIVEPTA-------------------------- >T_rubripes_ENSTRUP00000043508 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------APVINRF-CRRAS--VCAEAFNPDED-EEE----KEPL------------- ------------------VTYPKTDEQRQRLQEACRDILLFKN-LDPEE-MSQVLDAMFE KFCT----EGEHIIDQD--DEGNNFY--VI-E--SGTFSIFV-KT--DSTEKLVGCYDNR GSFGELALMYNTPRAATI--IATSP-GALWCLDRLTFRRIIV--KNNAKKRKMYESFI-- ET-LPLL-TSLELSERMKVVDVISSKVFNDSQQIIAQGDLADCFYIVESGQVRITIKRSR TKKDP-EEEEVDIAALSRGQYF-G-ELALVT--NKPRAASAY--AVGS-VKCLVMDVKAF ERLLGPCMDIM--------KRNIANYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVTLF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSTEI------------------------------- >O_cuniculus_ENSOCUP00000010967 -MS------IEIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AGLTELLQGFTVEVLRHQP------------ADLLEFALQHFTRLQQ ENERKGAARFGHEGRTWGDAGA-AA------GGGTPSKGVNFAEE--------------- ------------------------------------------------------------ ---------------------PAH-----------------SDSENGEEEEEEEEEAA-- --------------------------------------DAGAFN---------------- ---------APVINRF-TRRAS--VCAEAYNPDEE-EDD----AESR------------- ------------------XXXXKTDDPRNRLQEACKDILLFKN-LDPEQ-MSQVLDAMFE KLVK----EGEHVIDQG--DDGDNFY--VI-D--RGTFDIYV-KC--DGVGRCVGNYDNR GSFGELALMYNTPRAATI--TATSP-GALWGLXXXXXXXXXX--XXXXXXXXXXXXXX-- XX-XXXX-XXXXVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKG KSEVE-ENGAVEIARCSRGQYF-G-ELALVT--NKPRAASAH--AIGT-VKCLATLLQAF ERIY-PYMEIM--------HRKKATYQ--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLGAVL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GEVMDIVEDHA-------------------------- >O_cuniculus_ENSOCUP00000010696 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------CAEAYNPDEE-EED----TDPR------------- ------------------VIHPKTDEQRCRLQESCKDILLFKN-LDQEQ-LSQVLDAMFE RIVK----VDEHVIDQG--DDGDNFY--VI-E--XXXXXXXX-XX--XXXXXXXXXXXXX XXXXXXXXXXXXXXXXXX--XXXXX-XXXXXXDRVTFRRIIV--KNNAKKRKMFESFI-- ES-VPLL-KSLEXXXXXXXXXXXXXXXXXXXXXXXXXGEKADSFYIIESGEVSILIKSKT KSNKDGGNQEVEIARCHKGQYF-G-ELALVT--NKPRAASAY--AVGD-VKCLVMDVQAF ERLLGPCMDIM--------KRNISHYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVKIF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSMDLIDPGQ-------------------------- >T_rubripes_ENSTRUP00000028483 -MS-----KQQKPISPLKNFFAGGFGGVCLVFAGHPLDTIKVRLQTQPKPKPGETLLYKG TFDCFKKTLAKEGLKGLYKGMAAPIIGVTPMFAVCFFGFGLGKKLQQKSPDDILTYPQLF AAGMLSGVFTTAIMTPGERIKCLL-QIQASTG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------NVKY NGPMDCVKQLYRESGIRGIYKGTALTLMRDVP------------ASGMYFMT--YEWLKT LLTPPGKSHNELSIPSILFAGGMAGIFNWAVAIPPDVLKSRFQTA--------------- ------------------------------------------------------------ ---------------------PEG---------------------------------KYP NGFRDVL-------------------------------RELIRE---------------- ---------EGVASLY-KGFNA--VMLRAFPANAA-APV----TQRC------------- ------------------CSL-------------------------QEQ-FSEILDAMFE VLVK----PQQHIIDQG--DDGDNFY--VI-E--TGTFDIFV-KK--DGANLCVGKYDNK GSFGELALMYNTPRAATI--VATQD-GALWALDRATFHRLIV--KNNAKKRRMYEAFI-- ES-VALL-KSLELSERMKIVDALAARGFKDGERIITQGDDADCFYIVESGQVRIMIKSKT KVSEQ-NNVEVEVARCSRGHYF-G-ELALVT--NKPRAASVY--AVGE-TKCLVIDIQAF ERLLGPCMDIM--------KRNISLYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------DQLVALF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSDDL------------------------------- >T_nigroviridis_ENSTNIP00000017695 -MS-----KQQKPISPLKNFFAGGFGGVCLVFAGHPLDTIKVRLQTQPKAKPGETLLYRG TFDCFKKTLAKEGVRGLYKGMAAPIIGVTPMFAVCFFGFGLGKKLQQKSPDDVLTYPQLF AAGMLSGVFTTAIMTPGERIKCLLQQIQASTG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------KVKF NGPIDCVKQLYRESGIRGIYKGTALTLMRDVP------------ASGMYFMS--YEWLKN DLTPPGKSHNELSVPSILFAGGMAGIFNWAVAIPPDVLKSRFQTA--------------- ------------------------------------------------------------ ---------------------PEG---------------------------------KYP NGFRDVL-------------------------------RELVRE---------------- ---------EGVASLY-KGFNA--VMLRAFPANAS-PPP----ANPT------------- ------------------AEF-------------------------PEQ-FSEILDAMFE VLVK----PQQHIIDQG--DDGDNFY--VI-E--KGTFDIFV-QK--DGASLCVGKYDNK GSFGELALMYNTPRAATI--VATQE-GALWALDRATFHRLIV--KNNAKKRRMYEAFI-- ES-VPLL-KSLELSERMKIVDVLAARSFKDEERIITQGDEADCFYIVESGQVKIKIKSKT KVSEQ-NNGEVEVARCVRGQYF-G-ELALVT--NKPRAASVY--AVGE-TKCLVIDIQAF ERLLGPCMDIM--------KRNISLYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------DQLVALF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSEDL------------------------------- >G_gorilla_ENSGGOP00000003850 -MS------IEIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AGLTELLQGFTVEVLRHQP------------ADLLEFALQHFTRLQQ ENERKGTARFGHEGRTWGDVGA-AA------GGGTPSKGVNFAEE--------------- ------------------------------------------------------------ ---------------------PMH-----------------SDSEDG---EEEEAAPA-- --------------------------------------DAGAFN---------------- ---------APVINRF-TRRAS--VCAEAYNPDEE-EDD----AESR------------- ------------------IIHPKTDDQRNRLQEACKDILLFKN-LDPEQ-MSQVLDAMFE KLVK----DGEHVIDQG--DDGDNFY--VI-D--RGTFDIYV-KC--DGVGRCVGNYDNR GSFGELALMYNTPRAATI--TATSP-GALWGLXXXXXXXXXX--XXXXXXXXXXXXXX-- XX-XXXX-XXXXFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKITMKRKG KSEVE-ENGAVEIARCSRGQYF-G-ELALVT--NKPRAASAH--AIGT-VKCL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >A_gambiae_AGAP004940-PA -MSSQQKHRIQVP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------DGLRDVLLEFSIAYLLEQP------------GDVIDYAVTFFTKLQE DRKTTMITSAEP------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------TSPDESIMS-- --------------------------------------HDEGRY---------------- ---------KPLVNRYASRRKS--VFAETYDPEND-DED----EGAR------------- ------------------AIFPKTDEQRARLCDSVKNILLFRS-LDKEQ-MNEVLDAMFE KIVQ----AKDYIIKQG--DDGDNFY--VI-E--SGIYNAYV-GE--D--QKHIHTYDNR GSFGELALLYNMPRAATI--QAETD-GKLWAMDRQTFRRILL--KSAFRKRKMYEALL-- DA-VPML-KTLQNYERMNLADALIPQTYAKGDRIIKQGDAADGMYFIEDGKVSIRIQQ-- ------DAGEVEISNLEKGGYF-G-ELALVT--HRPRAASAY--AVDN-VKVAFLDVDAF ERLLGPCMNIM--------KRNIGDYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------TQLVKIF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSKNNITDIR--------------------------- >D_melanogaster_FBpp0087524 -MSSDSSRRIQVP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EELKEVLLQFSISFLVEQP------------PDVIDYAVEYFTKLQS ERPSVSHTDQST------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------DDQLSVNS-- --------------------------------------QDADA----------------- ---------EPPVMAS-SRRKS--VFAEAYDPEAD-DDD----DGAT------------- ------------------AVFPKTDEQRARLVESVKNVLLFRS-LEKEQ-MNQVLDAMFE RKVQ----PGDFIIRQG--DDGDNFY--VI-E--SGVYKVYI-ND------KHINTYNHT GLFGELALLYNMPRAATV--QAETS-GLLWAMDRQTFRRILL--KSAFRKRKMYEELL-- NS-VPML-KALQNYERMNLADALVSKSYDNGERIIKQGDAADGMYFIEEGTVSVRMDQ-- ------DDAEVEISQLGKGQYF-G-ELALVT--HRPRAASVY--ATGGVVKLAFLDVKAF ERLLGPCMDIM--------KRNIDDYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SQLVKIF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSKNNITDTR--------------------------- >O_anatinus_ENSOANP00000014875 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------DNGEED---- --------------------------------------REITPP---------------- ---------SPSWRRY-QRRAS--VQAEAINPGEG-SSVSSPAGVRW------------- ------------------AQHPKSAEQMKRLKETCETLLPFRE-LEEEL-LTQIFSAMFE RKVE----AQEHVVEQG--EDGDYFYAIAI-E--SGMYDLLV-AR--NKQDCRIGRYEDR GAFGELALMYSYPRPATI--VALTA-GVLWGLDRKTFRTITV--TFQAERRKKFESLI-- NS-VPFF-RSLEKSEKMKLLDMIESKTYRHGDCIFAQGEMADKFYIVESGEVKMLTEMP- ------TGKEVGIVKLNPGEYF-G-EGALVG--NKPRTSSAY--AVGD-AKCIVMNVEAL ERLLGPCLDIL--------KRDMAQFK--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------D-LIALH------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DSSVDLSEEHK-------------------------- >C_intestinalis_ENSCINP00000014963 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MGS ATNQDDEEMVAS------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------DNDDYMDE-- --------------------------------------AEEMAM---------------- ---------MARRTNV-SRRKS--VSAEGFDPDAD-DDD----DEEK------------- ------------------VIHPKTDEQRDRLSKVISKMLIFSS-LDIEQ-TQQVLDAMFE KSVK----AGDHVIDEG--DDGDNFY--VI-E--KGDFDIFI-NDPVTKVPDHKGTYKGS GAFGELALMYNCPRLATI--IATTD-GSLWGMDRTTFRRIIV--KNAAKKRKQYEDFL-- AT-VPLL-STLTVEERMKVADAMVTKNYEDEDCILKQGDPADYFYIVIDGQVVVKRRGDD PSN---ANHEVVLKKYTNGEYF-G-ELALIQ--NQPRAASAF--AEGP-CKCAVLDVQAF ERLLGPCKELL--------MRNIPLYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------QQLSEIY------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------QDMSMSE----------------------------- >M_domestica_ENSMODP00000000553 -GG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------STRAGVP------------SEGLSFQ--------- ----EERKEGGA------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------PDGGGKEEADPA-- --------------------------------------GAGVAG---------------- ---------AVVRGRY-QRRSS--IPAEAFGPSEGEEELMEETTVVW------------- ------------------AIYPKSEEQVRKLKEACKDLLPFRG-LEDEL-LLQIFSAMFE KKVL----PQEHVVEQG--EDGDHFY--VI-E--DGIFDVIV-QN--NSQHNIIGQYKHM GAFGELALMYSYPRPATI--VAITE-GSLWGLDRPTFRTITV--TFQLEKKKKIQMLL-- SN-VPFF-KSLEDTESVKILDVVEENNYQSGECIFPKGQTSDKFYIVESGEVKIVGEKL- ------GSKEAEIVRHHEEDFF-G-ESALIS--NKPRTTSAY--AVGK-VKCIVMDVQAL ERVLGPYMDIL--------KRDMSQYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------ELIKLL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GPQIDTKA----------------------------- >A_aegypti_AAEL009216-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------EPLVNRYASRRKS--VFAETYDPEAD-DDD----DGAR------------- ------------------AIFPKTDEQRARLCDSVKNILLFR--LMNTI-MNEVLDAMFE KKVK----AKDYIIKQG--DDGDNFY--VI-E--SGIYKAYV-GE--D--QKHIHTYDNS GSFGELALLYNMPRAATI--QAETD-GQLWAMDRQTFRRILL--KSAFRKRKMYEALL-- DA-VPML-KTLQSYERMNLADALIPKTFAKGERIIKQGDAADGMYFIEEGKVSIRIQQ-- ------DAGEVEISNLEKGQYF-G-ELALVT--HRPRAASAY--AVDN-VKVAFLQTDCF ERLLGKVLDVM--------LRGMKHYR--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------YVDQSVW------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KMILEACREENSQVR--------------------------- >C_familiaris_ENSCAFP00000031475 MAGPARRPARRRRGTGCAAGSAHPGHPPALGRRTAAADPPRPPPPPG--PGSRRSLPAPG PLPRRGPRGGVAHLSSETPHVGPPGRGGGWGRKGREKRQRRRGRRGGEGPRREAENSAEV DYRFMGLSDLPKCLRTMASGSTA------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------TSEE ERSLRECELYVQKHNIQALLKDSIVQLCTARP------------ERPMAFLREYFERLEK ----EEAKQIQN----LQKAS--------------------------------------- ------------------------------------------------------------ -----------------------------------------------SRADSREDEI--- --------------------------------------SP-PPP---------------- ---------NPVVKGR-RRRGA--ISAEVYTEE---DAA----SYVR------------- ------------------KVIPKDYKTMAALAKAIEKNVLFSH-LDDNE-RSDIFDAMFP VSFI----AGETVIQQG--DEGDNFY--VI-D--QGEMDVYV-NN------EWATSVGEG GSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSE ------NEEFVEVGRLGPSDYF-G-EIALLM--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSDIL--------KRNIQQYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFVSLSV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >M_mulatta_ENSMMUP00000002929 ------------------------------------------------------------ ------------------------------------------------------------ ----------------MESGSTA------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------ASEE ARSLRECELYVQKHNIQALLKDSIVQLCTARP------------ERPMAFLREYFERLEK ----EEAKQIQN----LQKAG--------------------------------------- ------------------------------------------------------------ -----------------------------------------------TRTDSREDEI--- --------------------------------------SP-PPP---------------- ---------NPVVKGR-RRRGA--ISAEVYTEE---DAT----SYVR------------- ------------------KVIPKDYKTMAALAKAIEKNVLFSH-LDDNE-RSDIFDAMFS VSFI----AGETVIQQG--DEGDNFY--VI-D--QGETDVYV-NN------EWATSVGEG GSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSE ------NEEFVEVGRLGPSDYF-G-EIALLM--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSDIL--------KRNIQQYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFVSLSV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >H_sapiens_ENSP00000351410 ------------------------------------------------------------ ------------------------------------------------------------ ----------------MESGSTA------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------ASEE ARSLRECELYVQKHNIQALLKDSIVQLCTARP------------ERPMAFLREYFERLEK ----EEAKQIQN----LQKAG--------------------------------------- ------------------------------------------------------------ -----------------------------------------------TRTDSREDEI--- --------------------------------------SP-PPP---------------- ---------NPVVKGR-RRRGA--ISAEVYTEE---DAA----SYVR------------- ------------------KVIPKDYKTMAALAKAIEKNVLFSH-LDDNE-RSDIFDAMFS VSFI----AGETVIQQG--DEGDNFY--VI-D--QGETDVYV-NN------EWATSVGEG GSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSE ------NEEFVEVGRLGPSDYF-G-EIALLM--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSDIL--------KRNIQQYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFVSLSV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >E_caballus_ENSECAP00000000501 ------------------------------------------------------------ ------------------------------------------------------------ ----------------MASGST-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE ERSLRECELYVQKHNIQALLKDSIVQLCTARP------------ERPMAFLREYFERLEK ----EEAKQIQN----LQKAG--------------------------------------- ------------------------------------------------------------ -----------------------------------------------TRADSREDEI--- --------------------------------------SP-PPP---------------- ---------NPVVKGR-RRRGA--ISAEVYTEE---DAA----SYVR------------- ------------------KVIPKDYKTMAALAKAIEKNVLFSH-LDDNE-RSDIFDAMFP VSFI----AGETVIQQG--DEGDNFY--VI-D--QGEMDVYV-NN------EWATSVGEG GSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSE ------NEEFVEVGRLGPSDYF-G-EIALLM--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSDIL--------KRNIQQYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFVSLSV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >A_carolinensis_ENSACAP00000000612 ------------------------------------------------------------ ------------------------------------------------------------ ---------------TMATSSSC------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------NLED DESLKGCELYVQKHNIQQILKECIVNLCIAKP------------DRPMKFLREHFEKLEK ----EECKQILA----CQKSN--------------------------------------- ------------------------------------------------------------ -----------------------------------------------SQSDSHDDEI--- --------------------------------------SP-PPP---------------- ---------NPAVKAR-HRRGG--VSAEVYTEE---DAV----SYVR------------- ------------------KVIPKDYKTMTALAKAISKNVLFAH-LDDNE-RSDIFDAMFP VTHI----AGEIVIQQG--DEGDNFY--VI-D--QGEVDVYV-NG------EWVTSIGEG GSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTLRKRKMYEKFL-- SK-VSIL-ESLEKWERLTVADALEPVQFEDGEKIVVQGQPGDDFFIITEGTASVLQRRSD ------KEEYVEVGRLGPSDYF-G-EIALLL--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSEIL--------KRNIQRYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFISLTV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_rubripes_ENSTRUP00000042610 ------------------------------------------------------------ ------------------------------------------------------------ ----------------VMASGST------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------SSEE ERSLRECEQYVQKHNIQQLLKDCIVQLCTSRP------------DRPMAFLREYFERLEK ----EEVKQIQN----QQKASN-------------------------------------- ------------------------------------------------------------ -----------------------------------------------SRSDSRDEEV--- --------------------------------------S--PPM---------------- ---------NPVVKGR-RRRGA--FSAEVYTEE---DAA----SYVR------------- ------------------KVIPKDYKTMAALAKAIEKNVLFSH-LDDNE-RSDIFDAMFP VTYI----AGETVILQG--DEGDNFY--VI-D--QGEMDVYV-NN------EWVTSIGEG GSFGELALIYGTPRAATV--RAKTN-VKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- RK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSE ------NEEFVEVGRLGPSDYF-G-EIALLM--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSDIL--------KRNIQQYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFVSLSV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >O_cuniculus_ENSOCUP00000014966 ------------------------------------------------------------ ------------------------------------------------------------ ----------------MASGSTA------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------ASEE ERSLQECELYVQKHNIRALLKDSIVQLCTARP------------ERPMAFLREYFERLEK ----EEAKQIQN----LQKAG--------------------------------------- ------------------------------------------------------------ -----------------------------------------------TRTDSREDEI--- --------------------------------------SP-PPP---------------- ---------NPVVKGR-RRRGA--ISAEVYTEE---DAA----SYVR------------- ------------------KVIPKDYKTMAALAKAIEKNVLFSH-LDDNE-RSDIFDAMFP VSFI----AGETVIQQG--DEGDNFY--VI-D--QGEMDVYV-NN------EWATSVGEG GSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSE ------NEEFVEVGRLGPSDYF-G-EIALLM--NRPRAATVV--ARGP-LKCVKQDRPRF ERVLGPCSDIL--------KRNIQQYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFVSLSV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >D_rerio_ENSDARP00000024266 ------------------------------------------------------------ ------------------------------------------------------------ -----------------MASGSV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------SSEE EKSLRECEVYVQKHNVQQLLKDCIVQLCTSRP------------DRPMAFLREYFERLEK ----EESKQLLN----QQKAS--------------------------------------- ------------------------------------------------------------ -----------------------------------------------SRSDSREDEV--- --------------------------------------S--PPM---------------- ---------NPVVKGR-RRRGA--ISAEVYTEE---DAA----SYVR------------- ------------------KVIPKDYKTMAALAKAIEKNVLFSH-LDDNE-RSDIFDAMFP VTYI----AGEIVIQQG--DEGDNFY--VI-D--QGEMDVYV-NN------EWATSIGEG GSFGELALIYGTPRAATV--RAKTN-VKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLDKWERLTVADALEPVQFEDSQKIVVQGEPGDEFFIILEGCAAVLQRRSE ------NEEFVEVGRLGPSDYF-G-EIALLM--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSDIL--------KRNIQQYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFVSLSV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >B_taurus_ENSBTAP00000011371 ------------------------------------------------------------ ------------------------------------------------------------ ---------------TMASGTT-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------ASEE ERSLRECELYVQKHNIQALLKDSIVQLCTARP------------ERPMAFLREYFEKLEK ----EEAKQIQN----LQKAG--------------------------------------- ------------------------------------------------------------ -----------------------------------------------SRADSREDEI--- --------------------------------------SP-PPP---------------- ---------NPVVKGR-RRRGA--ISAEVYTEE---DAA----SYVR------------- ------------------KVIPKDYKTMAALAKAIEKNVLFSH-LDDNE-RSDIFDAMFP VSFI----AGETVIQQG--DEGDNFY--VI-D--QGEMDVYV-NN------EWATSVGEG GSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSE ------NEEFVEVGRLGPSDYF-G-EIALLM--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSDIL--------KRNIQQYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFVSLSV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >G_aculeatus_ENSGACP00000012860 ------------------------------------------------------------ ------------------------------------------------------------ -----------------MASGST------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------SSEE ERSLRECEQYVQKHNIQQLLKDCIVQLCTSRP------------DRPMAFLREYFERLEK ----EEAKQIQN----QQKAGS-------------------------------------- ------------------------------------------------------------ -----------------------------------------------SRSDSRDEEV--- --------------------------------------S--PPM---------------- ---------NPVVKGR-RRRGA--FSAEVYTEE---DAA----SYVR------------- ------------------KVIPKDYKTMAALAKAIEKNVLFSH-LDDNE-RSDIFDAMFP VTYI----AGETVILQG--DEGDNFY--VI-D--QGEMDVYV-NN------DWVTSIGEG GSFGELALIYGTPRAATV--RAKTN-VKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- RK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSE ------NEEFVEVGRLGPSDYF-GSEIALLM--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSDIL--------KRNIQQYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFVSLSV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >P_pygmaeus_ENSPPYP00000010056 ------------------------------------------------------------ ------------------------------------------------------------ ----------------MESGSTA------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------ASEE ARSLRECELYVQKHNIQALLKDSIVQLCTARP------------ERPMAFLREYFERLEK ----EEAKQIQN----LQKAG--------------------------------------- ------------------------------------------------------------ -----------------------------------------------TRTDSREDEI--- --------------------------------------SP-PPP---------------- ---------NPVVKGR-RRRGA--ISAEVYTEE---DAA----SYVR------------- ------------------KVIPKDYKTMAALAKAIEKNVLFSH-LDDNE-RSDIFDAMFS VSFI----AGETVIQQG--DEGDNFY--VI-D--QGETDVRF-TN-------IKNIVGEG GSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSE ------NEEFVEVGRLGPSDYF-G-EIALLM--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSDIL--------KRNIQQYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFVSLSV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >D_rerio_ENSDARP00000021027 ------------------------------------------------------------ ------------------------------------------------------------ -----------------MASSST------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------SSEE ERSLRECERYVQKHNIQQLLKDCIVQLCTARP------------ERPMAYLRDYFEKLEL ----EEAKQMVS----QQKSS--------------------------------------- ------------------------------------------------------------ -----------------------------------------------SRSDSREDEV--- --------------------------------------S--PPM---------------- ---------NPVVKGR-RRRGA--ISAEVYTEE---DAT----SYVR------------- ------------------KVIPKDYKTMAALAKAIEKNVLFAH-LDDNE-RSDIFDAMFS VTYI----AGETVIQQG--DEGDNFY--VI-D--QGEMDVYV-NN------EWVTSIGEG GSFGELALIYGTPRAATV--RAKTN-VKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLDKWERLTVADALETVQFEDGQKIVVQGQPGDEFFIILEGSAAVLQRRSE ------NEEFVEVGRLAPSDYF-G-EIALLM--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSDIL--------KRNIQQYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFVSLSV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_guttata_ENSTGUP00000008775 ------------------------------------------------------------ ------------------------------------------------------------ ----------------MAAAASC------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------NVEE DESLKGCELYVQKHNIQQILKECIVNLCIAKP------------DRPMKFLREHFEKLEK ----EECKQILA----RQKSS--------------------------------------- ------------------------------------------------------------ -----------------------------------------------SQSDSHDDEI--- --------------------------------------SP-PPP---------------- ---------NPVVKAR-RRRGG--VSAEVYTEE---DAV----SYVR------------- ------------------KVIPKDYKTMTALAKAISKNVLFAH-LDDNE-RSDIFDAMFP VTHI----AGETVIQQG--DEGDNFY--VI-D--QGEVDVYV-NG------EWVTSIGEG GSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLDKWERLTVADALEPVQFEDGEKIVVQGEPGDDFFIITEGTASVLQRRSD ------NEEYVEVGRLGPSDYF-G-EIALLL--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSEIL--------KRNIQRYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFISLTV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >G_gallus_ENSGALP00000005814 ------------------------------------------------------------ ------------------------------------------------------------ ----------------MAAASSC------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------SVEE DESLKGCELYVQKHNIQQILKECIVNLCIAKP------------DRPMKFLREHFEKLEK ----EECKQILA----RQKSS--------------------------------------- ------------------------------------------------------------ -----------------------------------------------SQSDSHDDEI--- --------------------------------------SP-PPP---------------- ---------NPVVKAR-RRRGG--VSAEVYTEE---DAV----SYVR------------- ------------------KVIPKDYKTMTALAKAISKNVLFAH-LDDNE-RSDIFDAMFP VTHI----AGETVIQQG--DEGDNFY--VI-D--QGEVDVYV-NG------EWVTSIGEG GSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLDKWERLTVADALEPVQFEDGEKIVVQGEPGDDFFIITEGTASVLQRRSD ------NEEYVEVGRLGPSDYF-G-EIALLL--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSEIL--------KRNIQRYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFISLTV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >H_sapiens_ENSP00000385749 ------------------------------------------------------------ ------------------------------------------------------------ ----------------MASPPAC------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------PSEE DESLKGCELYVQLHGIQQVLKDCIVHLCISKP------------ERPMKFLREHFEKLEK ----EENRQILA----RQKSN--------------------------------------- ------------------------------------------------------------ -----------------------------------------------SQSDSHDEEV--- --------------------------------------SP-TPP---------------- ---------NPVVKAR-RRRGG--VSAEVYTEE---DAV----SYVR------------- ------------------KVIPKDYKTMTALAKAISKNVLFAH-LDDNE-RSDIFDAMFP VTHI----AGETVIQQG--NEGDNFY--VV-D--QGEVDVYV-NG------EWVTNISEG GSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSP ------NEEYVEVGRLGPSDYF-G-EIALLL--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSEIL--------KRNIQRYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFISLTV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >M_domestica_ENSMODP00000010661 ------------------------------------------------------------ ------------------------------------------------------------ ----------------MASSSSY------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------NLEE DESLKGCELYVQKHNIQQLLKECIVNLCISKP------------DRPMKFLREHFEKLEK ----EECKQILA----RQKLS--------------------------------------- ------------------------------------------------------------ -----------------------------------------------SQSDSHDDEI--- --------------------------------------SP-PPP---------------- ---------NPVVKAR-CRRGG--VSAEVYTEE---DAV----SYVR------------- ------------------KVIPKDYKTMTALAKAISKNVLFAH-LDDNE-RSDIFDAMFP VTHI----AGETVILQG--DEGDNFY--VI-D--QGEVDVYV-NM------EWVTNIGEG GSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLDKWERLTVADALETAQFEDGEKIVVQGQPGDDFFIITEGTASVLQRRSD ------NEEYVEVGRLGPSDYF-G-EIALLL--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSEIL--------KRNIQRYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFISLTV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >M_musculus_ENSMUSP00000026973 ------------------------------------------------------------ ------------------------------------------------------------ ----------------MASPSCF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------HSED EDSLKGCEMYVQKHGIQQVLKECIVHLCVAKP------------DRPLRFLREHFEKLEK ----EENRQILA----RQKSN--------------------------------------- ------------------------------------------------------------ -----------------------------------------------SQCDSHDEEI--- --------------------------------------SP-TPP---------------- ---------NPVVKAR-RRRGG--VSAEVYTEE---DAV----SYVR------------- ------------------KVIPKDYKTMTALAKAISKNVLFSH-LDDNE-RSDIFDAMFP VTHI----GGETVIQQG--NEGDNFY--VI-D--QGEVDVYV-NG------EWVTNISEG GSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSP ------NEEYVEVGRLGPSDYF-G-EIALLL--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSEIL--------KRNIQRYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFISLTV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >M_musculus_ENSMUSP00000020932 MTGPSPEPRVLRGSTQDARSVHQEHLSIRLRSAVVDPLGPPPLPTAGISLSAQRPVTPSP SLPSHSTQGGVAHLSPNRPTWVCGRR-----VEGREKRQRRGGRQTQEPPRNRGE--AEI SEQLNNLEDPPPHLRTMASGSMA------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------TSEE ERSLRECELYVQKHNIQALLKDSIVQLCTTRP------------ERPMAFLREYFERLEK ----EEARQIQC----LQKTG--------------------------------------- ------------------------------------------------------------ -----------------------------------------------IRTDSREDEI--- --------------------------------------SP-PPP---------------- ---------NPVVKGR-RRRGA--ISAEVYTEE---DAA----SYVR------------- ------------------KVIPKDYKTMAALAKAIEKNVLFSH-LDDNE-RSDIFDAMFP VSFI----AGETVIQQG--DEGDNFY--VI-D--QGEMDVYV-NN------EWATSVGEG GSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGTAAVLQRRSE ------NEEFVEVGRLGPSDYF-G-EIALLM--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSDIL--------KRNIQQYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFVSLSV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_guttata_ENSTGUP00000004221 ------------------------------------------------------------ ------------------------------------------------------------ ----------------MAASSSS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------SSEE ERSLRECELYIQKHNIQQLLKDCIVQLCTVRP------------ERPMGFIREYFERLEK ----EETKQLLN----QLKSG--------------------------------------- ------------------------------------------------------------ -----------------------------------------------SRSDSREDEI--- --------------------------------------SPPPPL---------------- ---------NPVVKYR-SRRGA--ISAEVYTEE---DAA----SYVR------------- ------------------KVIPKDYKTMAALAKAIEKNVLFTH-LDDNE-RSDIFDAMFP VTYI----AGETVIQQGKSDEGDNFY--VV-D--QGEMDVYV-NS------EWATSVGEG GSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GNTLRKRNMYEKFL-- SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGTAAVLQRRSE ------NEEFVEVGRLGPSDYF-G-EIALLM--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSDIL--------KRNIQQYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFVSLSV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >A_aegypti_AAEL015314-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------PLVNRYASRRKS--VFAETYDPEAD-DDD----DGAR------------- ------------------AIFPKTDEQRARLCDSVKNILLFRS-LDKEQ-MNEVLDAMFE KKVK----AKDYIIKQG--DDGDNFY--VI-E--SGIYKAYV-GE--D--QKHIHTYDNS GSFGELALLYNMPRAATI--QAETD-GQLWAMDRQTFRRILL--KSAFRKRKMYEALL-- DA-VPML-KTLQSYERMNLADALIPKTFAKGERIIKQG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >P_troglodytes_ENSPTRP00000045750 ------------------------------------------------------------ ------------------------------------------------------------ ----------------MESGSTA------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------ASEE ARSLRECELYVQKHNIQALLKDSIVQLCTARP------------ERPMAFLREYFERLEK ----EEAKQIQN----LQKAG--------------------------------------- ------------------------------------------------------------ -----------------------------------------------TRTDSREDEI--- --------------------------------------SP-PPP---------------- ---------NPVVKGR-RRRGA--ISAEVYTEE---DAA----SYVR------------- ------------------KVIPKDYKTMAALAKAIEKNVLFSH-LDDNE-RSDIFDAMFS VSFI----AGETVIQQG--DEGDNFY--VI-D--QGETDVYV-NN------EWATSVGEG GSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFI---GSAAVLQRRSE ------NEEFVEVGRLGPSDYF-G-EIALLM--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSDIL--------KRNIQQYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFVSLSV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >R_norvegicus_ENSRNOP00000033202 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MSPQIM--CVSVCGEGMG------------WDPVEISQSHAEGCAQ TTGLEENRQILA----RQKSN--------------------------------------- ------------------------------------------------------------ -----------------------------------------------SQCDSHDEEI--- --------------------------------------SP-TPP---------------- ---------NPVVKAR-RRRGG--VSAEVYTEE---DAV----SYVR------------- ------------------KVIPKDYKTMTALAKAISKNVLFSH-LDDNE-RSDIFDAMFP VTHI----DGETVIQQG--NEGDNFY--VI-D--QGEVDVYV-NG------EWVTNISEG GSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSP ------NEEYVEVGRLGPSDYF-G-EIALLL--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSEIL--------KRNIQRYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFISLTV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_nigroviridis_ENSTNIP00000015837 ------------------------------------------------------------ ------------------------------------------------------------ -----------------MASGST------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------SSEE ERSLRECEQYVQKHNIQQLLKDCIVQLCTSRP------------DRPMAFLREYFERLEK ----EEAKQIQN----QQKASN-------------------------------------- ------------------------------------------------------------ -----------------------------------------------SRSDSRDEEV--- --------------------------------------S--PPM---------------- ---------NPVVKGR-RRRGA---SAEVYTEE---DAA----TYVR------------- ------------------KVIPKDYKTMAALAKAIEKNVLFAH-LDDNE-RSDIFDAMFP VTYI----AGETVILQG--DEGDNFY--VI-D--QGEMDVYV-NN------EWVTSIGEG GSFGELALIYGTPRAATV--RAKTN-VKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- RK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSE ------NEEFVEVGRLGPSDYFAG-EIALLM--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSDIL--------KRNIQQYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFVSLSV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >G_aculeatus_ENSGACP00000006172 ------------------------------------------------------------ ------------------------------------------------------------ -----------------MASSST------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------SSEE ERSLQECEQYVQKHNIQQLLKECIIQLCTARP------------DRPMNFLRDHFERLQK ----EEAQQIAA----QQRSG--------------------------------------- ------------------------------------------------------------ -----------------------------------------------SRSDSREEEV--- --------------------------------------S--PPM---------------- ---------NPVVRGR-TRRGA--ISAEVYTEE---DAA----SYVR------------- ------------------KVIPKDYKTMAALAKAMEKNVLFAH-LDDNE-RSDIFDAMFS VNYI----AGETVIQQG--DEGDNFY--VI-D--VGEMDVYV-NN------ELVTSIGEG GSFGELALIYGTPRAATV--RAKSN-VKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLDKWERLTVADALEIVPFVDRQKIVVQGEPGDEFFIILEGTAAVLQRRSE ------DEEFVEVGRLGPSDYF-G-EIALLM--NRPRAATVV--ACGP-LKCVKLDRPRF ERVLGPCSDIL--------KRNIEQYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFVSLSV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >G_aculeatus_ENSGACP00000015074 ------------------------------------------------------------ ------------------------------------------------------------ -----------------MATSSS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------TLEE DESLKGCEIFVQKHNIQQILKECIVNLCIAKP------------ERPMKFLREHFEKLEK ----EECKQIMA----RQKSN--------------------------------------- ------------------------------------------------------------ -----------------------------------------------SQSDSHDDEV--- --------------------------------------SP-PPP---------------- ---------NPVVKAR-RRRGG--VSAEVYTEE---DAV----SYVR------------- ------------------KVIPKDYKTMTALAKAISKNVLFAH-LDDNE-RSDIFDAMFP VTHI----AGETVIQQG--DEGDNFY--VI-D--QGEVDVYV-NG------EWVTSIGEG GSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLDKWERLTVADALEPVQFEDGEKIVVQGEPGDDFFIITEGIASVLQRRSD ------NEEYVEVGRLGPSDYF-G-EIALLL--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSEIL--------KRNIQRYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFISLTV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >C_familiaris_ENSCAFP00000016544 ------------------------------------------------------------ ------------------------------------------------------------ ---------------TMASQSSY------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------QVEE DESLKECELYVQKHGVQQVLKDCIVHLCISKP------------DRPMTFLREHFEKLEK ----EENRQIQS----QQK----------------------------------------- ------------------------------------------------------------ -------------------------------------------------SDSHDEEV--- --------------------------------------SP-TPP---------------- ---------NPVVKAR-RRRGG--VSAEVYTEE---DAV----SYVR------------- ------------------KVIPKDYKTMTALAKAISKNVLFAH-LDDNE-RSDIFDAMFP VTHI----AGETVIQQG--DEGDNFY--VI-D--QGEVDVYV-NG------EWVTSISEG GSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFFIITEGTASVLQRRSP ------NEEYMEVGRLGPSDYF-G-EIALLL--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSEIL--------KRNIQRYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFISLTV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >O_latipes_ENSORLP00000010584 ------------------------------------------------------------ ------------------------------------------------------------ ----------------KMATSSS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------TLEE DESLKSCEIFVQKHNIQQILKECIVNLCIAKP------------ERPMKFLREHFEKLEK ----EECKHIMA----RQKSN--------------------------------------- ------------------------------------------------------------ -----------------------------------------------SQSDSHDDEV--- --------------------------------------SP-PPP---------------- ---------NPVVKAR-RRRGG--VSAEVYTEE---DAV----SYVR------------- ------------------KVIPKDYKTMTALAKAISKNVLFAH-LDDNE-RSDIFDAMFP VTHI----AGETVIQQG--DEGDNFY--VI-D--QGEVDVYV-NG------ELVTNIGEG GSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLDKWERLTVADALEPVQFEDGEKIVVQGEPGDDFFIITEGIASVLQRRSD ------NEEYVEVGRLGPSDYF-G-EIALLL--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSEIL--------KRNIQRYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFISLTV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >A_carolinensis_ENSACAP00000013014 ------------------------------------------------------------ ------------------------------------------------------------ ---------------TMAASGSS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------SSEE DRSLRECEQYVQKHNIQQLLKDCIVQLCTVRP------------ERPMVFLREHFEKLEK ----EETKQFLT----QQK----------------------------------------- ------------------------------------------------------------ -----------------------------------------------SRTDSREDEI--- --------------------------------------SPPPPM---------------- ---------NPVVKGR-RRRGA--ISAEVYTEE---DAA----SYVR------------- ------------------KVIPKDYKTMAALAKAIEKNVLFAH-LDDNE-RSDIFDAMFP VTYI----AGETVIQQG--KEGNNFY--VI-D--QGEMDVYV-NN------EWATSVGEG GSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGTAAVLQRRSE ------HEEFVEVGRLAPSDYF-G-EIALLM--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSDIL--------KRNIQQYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFVSLSV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >G_gallus_ENSGALP00000006731 ------------------------------------------------------------ ------------------------------------------------------------ ----------------MATSSSS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------SSEE ERSLRECELYVQKHNIQQLLKDCIVQLCTVRP------------DRPMGFLREYFERLEK ----EETKQLLN----QQKSG--------------------------------------- ------------------------------------------------------------ -----------------------------------------------SRSDSREDEI--- --------------------------------------SPPPPM---------------- ---------NPVVKGR-RRRGA--ISAEVYTEE---DAA----SYVR------------- ------------------KVIPKDYKTMAALAKAIEKNVLFAH-LDDNE-RSDIFDAMFP VTYI----AGETVIQQGKCDEGDNFY--VV-D--QGEMDVYV-NN------EWATSVGEG GSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILMASGSTLRKRKMYEEFL-- SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGTAAVLQRRSE ------NEEFVEVGRLAPSDYF-G-EIALLM--NRPRAATVV--ARGL-LKCVKLDRPRF ERVLGPCSDIL--------KRNIQQYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFVSLSV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >D_melanogaster_FBpp0099624 ------------------------------------------------------------ ------------------------------------------------------------ -----------------MSYMMA------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------KTLE EQSLRECEHYIQTHGIQRVLKDCIVQLCVCRP------------ENPVQFLRQYFQKLER ----EQVKLDAS----RQVIS--------------------------------------- ------------------------------------------------------------ -------------------------------------------------PDDCEDLS--- -----------------------------------------PMP---------------- ---------QTAAPPV-RRRGG--ISAEPVTEE---DAT----NYVK------------- ------------------KVVPKDYKTMNALSKAIAKNVLFAH-LDESE-RSDIFDAMFP VNHI----AGENIIQQG--DEGDNFY--VI-D--VGEVDVFV-NS------ELVTTISEG GSFGELALIYGTPRAATV--RAKTD-VKLWGIDRDSYRRILM--GSTIRKRKMYEEFL-- SR-VSIL-ESLDKWERLTVADSLETCSFDDGETIVKQGAAGDDFYIILEGCAVVLQQRSE ------GEDPAEVGRLGSSDYF-G-EIALLL--DRPRAATVV--ARGP-LKCVKLDRARF ERVLGPCADIL--------KRNITQYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFVSLSV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_rubripes_ENSTRUP00000007339 ------------------------------------------------------------ ------------------------------------------------------------ -----------------MATSSS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------TIDE DDSLKGCEIFVRKHNIQQILKECIVNLCITKP------------ERPMKFLREHFEKLEK ----EECKQIMA----RQKSN--------------------------------------- ------------------------------------------------------------ -----------------------------------------------SQSDSHDDEV--- --------------------------------------SP-PPP---------------- ---------NPVVKAR-RRRGG--VSAEVYTEE---DAV----SYVR------------- ------------------KVIPKDYKTMTALARAISKNVLFAH-LDDNE-RSDIFDAMFP VTHI----AGETVIQQG--DEGDNFY--VI-D--QGEVDVYV-NG------ELVTNIGEG GSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSILAESLDKWERLTVADALEPVQFEDGEKIVVQGAPGNDFFIITEGIASVLQRRSD ------NEEYVEVGRLGPSDYF-G-EIALLL--NRPRAATVV--ARGP-LKCVKLDRIRF ERVLGPCSEIL--------KRNIQRYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFISLTV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >D_rerio_ENSDARP00000095574 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NEASQVGTQKSLLSLH-CINNDFSSDIFDAMFP VTHI----AGETVIQQG--DEGDNFY--VI-D--QGEVDVYV-NG------EWVTSIGEG GSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLDKWERLTVADALEPVQFEDGEKIVVQGEPGDDFFIIIEGTASVLQRRSD ------NEEYVEVGRLGPSDYF-G-EIALLL--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSEIL--------KRNIQRYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFISLTV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >A_aegypti_AAEL002277-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MFDQLKK------------------------------KVYRRQQKL ----EQAKLDAS----KQAAS--------------------------------------- ------------------------------------------------------------ -------------------------------------------------PDDLDDLS--- -----------------------------------------PMP---------------- ---------QTTAPPV-RRRGG--ISAEPVSEE---DAT----SYVK------------- ------------------KVVPKDYKTMAALSKAIAKNVLFAH-LDENE-RSDIFDAMFP CTFL----PGESIIQQG--DEGDNFY--VI-D--IGEVEVFV-NN------ELVTTISEG GSFGELALIYGTPRAATV--RAKTD-VKLWGIDRDSYRRILM--GSTIRKRKMYEEFL-- SR-VSIL-ESLDKWERLTVADALEPVSFEDGETIVRQGEPGNDFYIIVEGCATVRQKRDE ------NEEPAEVGRLGPSDYF-G-EIALLL--DRPRAATVI--ARGP-LKCVKLDRARF ERVLGLCADIL--------KRNITQYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFVSLSV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_nigroviridis_ENSTNIP00000021133 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------Q ----EECKQIMA----RQKSN--------------------------------------- ------------------------------------------------------------ -----------------------------------------------SQSDSHDDEV--- --------------------------------------SP-PPP---------------- ---------NPVVKAR-RRRGG--VSAEVYTEE---DAV----SYVR------------- ------------------KVIPKDYKTMTALARAISKNVLFAH-LDDNE-RSDIFDAMFP VTHI----AGETVIQQG--DEGDNFY--VI-D--QGEVDVYV-NG------ELVTNIGEG GSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLDKWERLTVADALEPVQFEDGEKIVVQGAPGNDFFIITEGIASVLQRRSD ------NEEYVEVGRLGPSDYFAG-EIALLL--NRPRAATVV--ARGP-LKCVKLDRIRF ERVLGLCSEIL--------KRNIQRYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFISLTV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >A_gambiae_AGAP006448-PB ------------------------------------------------------------ ------------------------------------------------------------ --------------------MSN------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------AQEE EQHLRECESYIQTHCIQRLLKDCIVQLCVSRP------------ENPIVFLRQYFQKLER ----EQAKLDAS----KQAVT--------------------------------------- ------------------------------------------------------------ -------------------------------------------------PDDLDDLS--- -----------------------------------------PMP---------------- ---------QTAVPPV-RRRGG--ISAEPVTEE---DAT----SYVK------------- ------------------KVVPKDYKTMAALSKAIAKNVLFSH-LDENE-RSDIFDAMFP CNFL----PGEPIIQQG--DEGDNFY--VI-D--IGEVEVFV-NN------EQVTTISEG GSFGELALIYGTPRAATV--RAKTD-VKLWGIDRDSYRRILM--GSTIRKRKMYEEFL-- SR-VSIL-ESLDKWERLTVADALEPVSFEDGETIVRQGEPGNDFYIIVEGCATVMQKRGD ------SEEAAEVGRLGPSDYF-G-EIALLL--DRPRAATVI--ARGP-LKCVKLDRARF ERVLGLCADIL--------KRNITQYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFVSLSV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >O_anatinus_ENSOANP00000011151 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------KCLLITTLTQILNPAP------------KNPVKAGRKYFEGLQ- ----EECKQILA----RQKSN--------------------------------------- ------------------------------------------------------------ -----------------------------------------------SQSDSHDDEI--- --------------------------------------SP-PPP---------------- ---------NPVVKAR-RRRGG--VSAEVYTEE---DAV----SYVR------------- ------------------KVIPKDYKTMTALAKAISKNVLFAH-LDDNE-RSWIFFSLVP HFWVNFALAYILCLVLG--DEGDNFY--VI-D--QGEVDVYV-NG------EWVTSIGEG GSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLDKWERLTVADALEPVQFEDGEKIVVQGEPGDDFFIITEGTASVLQRRSD ------NEEYVEVGRLGPSDYF-G-EIALLL--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSEIL--------KRNIQRYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFISLTV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >S_cerevisiae_YIL033C -MV------SSLP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KESQAELQLFQNEINAANP------------SDFLQFSANYFNKRLE ----QQRAFLKA----REPEFKAKNIVLFPEPEESFSRPQSAQSQSRSRSSVMFK----- ------------------------------------------------------------ --------------------SPFVNEDPHSNVFKSGFNLDPHEQDTHQQAQEEQQHTRE- --------------------------------------KTSTPP---------------- ---------LPMHFNA-QRRTS--VSGETLQPNN--FDD----WTPD------------- ------------------HYKEKSEQQLQRLEKSIRNNFLFNK-LDSDS-KRLVINCLEE KSVP----KGATIIKQG--DQGDYFY--VV-E--KGTVDFYV-ND------NKVNSSGPG SSFGELALMYNSPRAATV--VATSD-CLLWALDRLTFRKILL--GSSFKKRLMYDDLL-- KS-MPVL-KSLTTYDRAKLADALDTKIYQPGETIIREGDQGENFYLIEYGAVDVSKKGQG -----------VINKLKDHDYF-G-EVALLN--DLPRQATVT--ATKR-TKVATLGKSGF QRLLGPAVDVL--------KLNDPTRH--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >X_tropicalis_ENSXETP00000002916 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SDIFDAMFP VNHI----AGETVIQQG--DEGDNFY--VI-D--QGEADVYV-NG------EWVTNIGEG GSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLDKWERLTVADALEPVQFEDGEKIVVQGEPGDDFFIITEGTASVLQRRSD ------NEEYVEVGRLGPSDYF-G-EIALLL--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSEIL--------KRNIQRYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFISLTV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >M_domestica_ENSMODP00000005486 ------------------------------------------------------------ ------------------------------------------------------------ ----------------IMATSGA------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------SSEE ERSLRECELYVQKHNIQALLKDSIVQLCTVRP------------DRPMAFLREYFERLEK ----EESKQLQALALPVQKAV--------------------------------------- ------------------------------------------------------------ -----------------------------------------------ILAETREEEI--- --------------------------------------SP-PPP---------------- ---------NPVVKGR-RRRGA--ISAEVYTEE---DAA----SYVR------------- ------------------KVIPKDYKTMAALAKAIEKNVLFSH-LDDNE-RSDIFDAMFP ASFI----AGETVIQQG--DEGDNFY--VI-D--QGEMDVYV-NN------EWATSVGEG GSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSE ------NEEFVEVGRLGPSDYF-G-EIALLM--NRPRAATVV--ARGP-LKCVKLDRPRF ERP----RPLL--------RHPQTQHP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------AVQQLCV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------TICLKFGSLA--------------- >C_elegans_R07E4.6c -MNNYSGDIVFMS----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------GGNE EDQLAQCQAYVQRHNIQQLVKEAIVVLCIHKP------------DNPVLFLKDHFEKLNE ----QRAQEGGN------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------PDAADDDD--- -----------------------------------------IIV---------------- ---------EPPKRSG-GRRTG--ISAEPIKED---DT-----EYKK------------- ------------------VVIPKDDATRRSLESAMRKNLLFAH-LEEDE-QKTMYDAMFP VEKS----AGETIIEQG--EEGDNFY--VI-D--KGTVDVYV-NH------EYVLTINEG GSFGELALIYGTPRAATV--IAKTD-VKLWAIDRLTYRRILM--GSVTKKRKMYDEFL-- SK-VQIL-ADLDQWERANVADALERCDFEPGTHVVEQGQPGDEFFIILEGEANVLQKRSD ------DAPFDVVGHLGMSDYF-G-EIALLL--DRPRAATVV--AKTH-LKCIKLDRNRF ERVMGPVREIL--------KRDVSNYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SYVKLMT------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >O_anatinus_ENSOANP00000012829 ------------------------------------------------------------ ------------------------------------------------------------ -----------------MASGSS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------SSEE ERSLRECEHYVQKHNIQALLKDCIVQLCTSRP------------ERPMAFLREIFEKLEK ----EEAKQLQN----LQKAS--------------------------------------- ------------------------------------------------------------ -----------------------------------------------SRSDSREDEI--- --------------------------------------SPPPPM---------------- ---------NPVVKGR-RRRGA--ISAEVYTEE---DAA----SYVR------------- ------------------KVIPKDYKTMAALAKAIEKNVLFAH-LDDNE-RSDIFDAMFP VTYI----AGETVIQQG--DEGDNFY--VV-D--QGEMDVYV-NN------EWATSVGEG GSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSE ------NEEFVEVGRLGPSDYF-G-EIALLM--NRPRAATVV--ARGP-LKCVKLDRPRF ERP----GSLL--------GHPQAKHP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------AVQQLRL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------AVRLKRRSPARSRLHQRRLLSLLHS >O_latipes_ENSORLP00000004817 ------------------------------------------------------------ ------------------------------------------------------------ -----------------MASGST------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------SSEE ERSLRECEQYVQKHNIQQLLKDCIVQLCTSRP------------DRPMAFLREYFERLEK ----EEAKQIQN----QQKAGS-------------------------------------- ------------------------------------------------------------ -----------------------------------------------SRSDSRDEEV--- --------------------------------------S--PPM---------------- ---------NPVVKGR-RRRGA--FSAEVYTEE---DAA----SYVR------------- ------------------KVIPKDYKTMAALAKAIEKNVLFAH-LDDNE-RSDIFDAMFP VTYI----AGETVILQG--DEGDNFY--VI-D--QGEMDVYV-NN------EWVTSIGEG GSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- RK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSE ------HEEFVEVGRLGPSDYF-G-EIALLM--NRPRAATVV--ARGP-LKCVKLDRPRF E---GP-GPLL--------GHTQTQHP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------TVQQLCV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------AVRLRERLSSPSLLPSPLTLRPLRP >C_intestinalis_ENSCINP00000005337 ------------------------------------------------------------ ------------------------------------------------------------ -----------------ICDITM------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------AGEE EQGLKECEAYVHEHKIQQTLKDCIVQLCIHKP------------EKPMKFLREHFEALEK ----EEAAPPSPSST-NEKSN--------------------------------------- ------------------------------------------------------------ -----------------------------------------------QESGEEEPAV--- -----------------------------------------TPP---------------- ---------TKLFQT--QRRGA--VSAEVYTDD---DQS----PKSNSHLNNVKLIFPPI KLSFYKQPQQLCPKPQSFQVITKDYKTMASLSKAIEKNVLFAH-LDDNE-RSDIFDAMFP VQHI----AGEYIIKQG--DDGDNFY--VM-D--QGEVDIII-NN------NYITTLGDG ASFGELALIYGTPRAADV--RAKTD-LKLWAIDRDSYRRILM--GSTLKKRKMYDEFL-- SK-VSIL-ESLDKWERLTVADALEPAQFESGQEVVVQGDSGSDFYIIVEGTAAVLQRRSD ------NEEYTQVGTLGASDYF-G-EIALLL--DRPRAATVV--ARSV-LKCVKLDRPRF ERVLGECSEIL--------KRNIQQYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SYVSLSV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >E_caballus_ENSECAP00000003303 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MFP VTHI----AGETVIQQG--DEGDNFY--VM-D--QGEVDVYV-NG------EWVTSISEG GSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLEKWERLTVADALEPVQFEDGEKIVVQGQPGDDFFIITEGTASVLQRRSP ------NEEYMEVGRLGPSDYF-G-EIALLL--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSEIL--------KRSIQRYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFISLTV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_nigroviridis_ENSTNIP00000014931 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------DED-DED----LEPR------------- ------------------VVNPKTDEQRRRLQEACRDVLLFTT-LDQATERMSILDVSRV KQFS----DSERIIKQG--DKADCFY--IV-E--SGEVKIMM-RS------KVSCSFPLS TSLFQLCAVHLTSLFPGV--FSLAT-GGI-NVVCVLLRKIIK--NNTLKLLGNTKVFILF SP-VSCL-PGFSVQTNTDQADA-------------------------------------- --------AEVETARCSRGQHF-G-ELALVT--DKPRAASAY--AVGD-VKCLVIDAQTF ERLLGSCKEIM--------KSNVTQYE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EQLVALF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSIDL------------------------------- >G_gorilla_ENSGGOP00000011641 ------------------------------------------------------------ ------------------------------------------------------------ ----------------MASPPAC------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------PSEE DESLKGCELYVQLHGIQQVLKDCIVHLCISKP------------ERPMKFLREHFEKLEK ----EENRQILA----RQKSN--------------------------------------- ------------------------------------------------------------ -----------------------------------------------SQSDSHDEEV--- --------------------------------------SP-TPP---------------- ---------NPVVKAR-RRRGG--VSAEVYTEE---DAV----SYVR------------- ------------------KVIPKDYKTMTALAKAISKNVLFAH-LDDNE-RXXXXXXXXX XXXX----XXXXXXXXX--NEGDNFY--VI-D--QGEVDVYV-XG------EWVTNISEG GSFGELALIYGTPRAATV--KAKTD-XXXXXXXXXXXXXXXX--GSTLRKRKMYEEFL-- SK-VSIL-ESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSP ------NEEYVEVGRLGPSDYF-G-EIALLL--NRPRAATVV--ARGP-LKCVKLDRPRF ERVLGPCSEIL--------KRNIQRYN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SFISLTV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >X_tropicalis_ENSXETP00000024459 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------QVIPKDYKTMAALAKAIEKNVLFAH-LAGNS-H-DIFDAMFS VTYI----AGETVIQQG--DEGDNFY--VV-D--QGEMDVYV-NN------DWMTSIGEG GSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSE ------NEEFVEVGRLGPSDYF-G-E---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_rubripes_ENSTRUP00000047709 -T---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------G----- ----------TL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------RDLQ LAL----------QLKIEELRQRDALIDEL--------------ELELDTKDDLIRQLQI E-------LDRY----RSSSQQALSSQ--------------------------------- ------------------------------------------------------------ --------------------ETANT-------------------GAAVQTVFAS------ ------------------------------------------------------------ ------------DEPLRIKRQA--ISAEPSG--LD-PAKLTDVTL--------------- ------------------TSYLKTKESGELIQKALMNNDFMKH-LEHGQ-ILTIMDCMYP TTLS----KGCCVIQEG--DDGSTVY--VL-E--EGMVEVTK-QG------KTLCTIGPG KVFGELAILYNCTRTASV--TALTD-IKLWAIDRQNFQTIMM--RSGVIKHSQYMDFL-- RS-IPSF-QSLPEDGLSKLADVLEETHYGDSDYIIRQGATGDTFFIISEGQVKVSQQNSP ------SDEQVTVTTLSKGDWF-G-EQALKG--EDVRTASYT--AVG-DVTCLVIDRESF KQLIGGLDEVK--------KKQCENNE---------------VKEK-------------- -------LQAEADFFSSVSLNDFN------------------------------------ -----------------TI----CTLGMGGFSRVEL---VQ-LKNE-TNRSFALKVLKKR HIVDTSQQGHILSERHIMMEAHSPFIVRLYR--------TFKDSKFLYMLLEACLGGELW TLLRDKGSFDDSTTRFYTGCVIEALAFLHTRGIIYRDLKPENIILDNRGYAKLVDFGFAK KVGLGKKTWTFCGTPEYVAPEIILNKGHDSSADCWSLGILIFELLSGSPPFSGSDPMMTY NIILRGIDMIEFPKKITKSAATLIKRLC-RLSIVHIRINQKNGVKDIQKHKWFEGFNWEG LRQGNIDPPYTPTVDGPQDNSNFDYFPLDTDGPPPDE------ESGWDLEF >C_intestinalis_ENSCINP00000010398 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------PKTGTQVAQIKRALNSNVFLKG-LDANQ-VEQLMDCMSL QTVS----AGSEIIAEG--EYGTHMY--VL-D--KGQVKCRSGER------SHVIDLNPG TVFGELAILYNCKRTAYV--EAKTD-VTIWSIDRQLFQTVVK--KSGQSKRDEYVRLL-- RT-VDRL-KSLSENKLLRIADCLEQTTFRMGDYIIRQGDSGDTFYVIQEGSVKVTQNKTG FFNKMKSREEDFLCNMEKGEYF-G-ERALLT--EDKRAANVI--ADSDVVTLLMLDRQAF SSLIGSLAEVGKTPSVPQLPLESEDPSHLDETDGRLRELAVVPEEDEEHVLSEGNHLAPK VTIVTRLSGATESVLKRTKLEDLKVRLHILLSYTVAQFFIGYSVGQFVLQGCILLFLVRK FIDTAFSAQYAVNRLNAVI----RILGQGGFGCVKL---VQ-VPGL-SNCAFALKAIRQA KIVKTGQQQHVLAEKNIMLAAKSPFIARLYRYTSSAHDTTYKDSSRIYMLMDAYLGGEMY GVLKRMGSLDEIAARFCAGCVLEALSYLHERGIVYRDLKPENLMLDHRGYVKLVDFGFAK RVRFGFKTWTFCGTPEYFPPEILSNAGHDFSADYWSYGILIYELLTRTTPFFAGDDMTVY EGILGGIEGVKFSKRVKRSAELLIRNLC-KLEPRDRLGYQKGGVNDIRKHRWFHGFDWQG LRTTSIKSPFKVHIKNAVDTNNFEPCLEELADETDDAEVLRDANMVWAESF >T_nigroviridis_ENSTNIP00000016594 -T---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------G----- ----------TL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------RDLQ LAL----------QLKIEELRQRDALIDEL--------------ELELDTKDDLIRQLQI E-------LDRY----RSSSQQALSSQ--------------------------------- ------------------------------------------------------------ --------------------ETANT-------------------GAVVQAAPAF------ ------------------------------------------------------------ ------------DEPLRIKRQA--ISAEPSA--LD-PSKLTDVML--------------- ------------------TSYLKTKESGELIQKALMNNDFMKH-LEHGQ-ILTIMDCMYP TSLS----KGCCVIQEG--DDGSTVY--VL-E--EGMVEVTK-QG------KKLCTIGPG KVFGELAILYNCTRTASV--TALTD-IKLWAIDRQNFQTIMM--RSGVIKHSQYMDFL-- RS-VPSF-QSLPEDVLSKLADVLEETHYGDSDYIIRQGATGDTFFIISEGQVKVSQQGSP ------SDEQVAVTLLSKGDWF-G-EQALKG--EDVRTASYT--AVG-DVTCLVIDRESF KQLIGGLDDVK--------NKQCESNE---------------VKAK-------------- -------LQAEADFFSSVSLKDFN------------------------------------ -----------------II----CTLGMGGFSRVEL---VQ-LKNE-TNRSFALKVLKKR HIVDTSQQGHILSERQIMMEAHSPFIVRLYR--------TFRDPKYLYMLLEACLGGELW TLLRDRGSFDDSTTRFYTGCVIEALAFLHSGGIIYRDLKPENIILDNRGYAKLVDFGFAK KVGLGKKTWTFCGTPEYVAPEIILNKGHDSSADCWSLGILIFELLSGSPPFSGSDPMMTY NIILRGIDMIEFPKKITKSAATLIKRLC-RDNPSERLGNQKNGVKDIQKHKWFEGFNWEG LRQGSIDPPYTPTVDGPLDNSNFDYFPEDTDS-PPDE------ESGWDLEF >D_rerio_ENSDARP00000085704 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------TKKLINEALMKNDFLKK-LEPQH-TREMVDCMYE KIYG----AEQLVIQEG--EPGNFLY--VL-A--EGLLEVIQ-NG------KFLGQMRPG TAFGELAILYNCKRTATV--KAVSQ-SHIWALDRQTFQTIMM--RSTQARHEEYFSFL-- RS-VSLL-KDLPEEKLAKIIDCLEIDYFDKGEYIIREGEEGNTFFIIAKGEVSVTQTTEG ------FTEPQEIKTLRVGDYF-G-EKALIS--EDVRSANII--AKENDTQCLVVDRDNF NEMVGTYEELQ--------------------------------------------ERSPE AAELRRLKEKATALSSTSFLKELQ------------------------------------ -----------------VV----ATLGMGGFGRVEL---VK-LKDS-EDTAFALKCIKKK HIVDTRQQEHIYSEKIILQQTNSNFIVRLFR--------TFRDDKFVYMLLEVCLGGELW SLLRDMSCFDEPTARFCTGCVLEAFDYLHGKGIVYRDLKPENLLLDAEGYVKMADFGFAK KIGLGKKTWTFCGTPEYVAPEVIMNKGHDFGADCWSLGILIFELLIGSPPFTGSDPIRIY TMVLHGIEKVDIPKRISKRPEDLIRRLC-KLNPAERLGNKKNGIIDIKKHKWFQGFNWEG LRRRKLMSPLRRELKGPLDHSYFDMFPPE-LEEPPDE------FSGWDKDF >T_nigroviridis_ENSTNIP00000006171 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------G----- ----------TL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------RDLQ YAL----------QLKIEELRQRDTLIDEL--------------ELELDQKDELIQRLQN E-------LDKY----RSVLRPATAQQ--------------------------------- ------------------------------------------------------------ --------------------VQAQ-----------------------QQSLVLQ------ ------------------------------------------------------------ ------------PDQHRSKRQA--ISAEPTA--CD-ISDLSHVTL--------------- ------------------PFYPKSPESKDMIREAILDNDFMKN-LELSQ-IHEIVDCMYP VEYG----KDACIIEEG--DVGSLVY--VM-E--EGKVEVTK-EG------MKLCTMGPG KVFGELAILYNCTRTATV--RTLVP-VKLWAIDRQCFQTIMM--RTGLIKHAEYMDFL-- KS-VPTF-KGLPEETLSKLADVMEETHYEDGDYIIRQGARGDTFFIISNGKVNVTQEDSS ------NQEPVHLRELTRGDWF-G-ERALQG--EDVRTANVI--AAD-AVTCLVIDRDSF KHLIGGLEEVS--------NRGYEDLE---------------AKAK-------------- -------YEAENAFFSSLKLNDFN------------------------------------ -----------------IV----DTLGVGGFGRVEL---VQ-LKKE-EAKTFAMKILKKR HIVDTRQQEHIRSEKQIMSEAHCDFIVRLYR--------TFKDSKYLYMLMEACLGGELW TILRDRGSFDDSTTRFYTGCVVEAFAYLHAKGIIYRDLKPENLILDSYGYAKLVDFGFAK KISICKKTWTFCGTPEYVAPEIILNKGHDVSADYWSLGILMYELLTGSPPFSGPDPMKTY NIILRGIDMVEFPKKVTKNASNLIKKLC-RDNPSERLGNQKNGVKDIQKHKWFEGFNWEG LRKGTLTPPITPDVSSPTDTSNFDSFPEDTDEPPPDD------NSGWDYDF >T_nigroviridis_ENSTNIP00000011460 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------G----- ----------TL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------RDLQ YAL----------QEKIEELRQRDALIDEL--------------ELELDQKDELIQRLQN E-------LDKY----RSVIKPAT-QQ--------------------------------- ------------------------------------------------------------ --------------------VHKQ---------------------------TEL------ ------------------------------------------------------------ ------------QEHQRTKRQA--ISAEPTA--FD-IQDLSHVTL--------------- ------------------PFYPKSPQSKDLIKEAILDNDFMKN-LELSQ-IQEIVDCMYP VEYG----KDSCIIKEG--DVGSLVY--VM-E--DGKVEVTK-ES------LKLCTMGPG KVFGELAILYNCTRTATV--KTLTN-VKLWAIDRQCFQTIMM--RTGLIKHTEYMEFL-- KS-VPTF-QGLQEDILSKLADVLEETHYEDGEYIIRQGARGDTFFIISKGKVNVTREDSP ------NGEPVYLRSLGKGDWF-G-EKALQG--EDIRTANVI--AAE-AVTCLVIDRDSF KHLIGGLEDVS--------SKGHEDAD---------------AKAKRDR----------- -------YEAENAFFFNLNLADFN------------------------------------ -----------------II----NTLGVGGFGRVEL---VQ-LKSD-ENKTFAMKILKKR HIVDTRQQEHIRSEKLIMQEAHSDFIVRLYR--------TFKDSKYLYMLMEACLGGELW TILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAK KIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMFELLTGSPPFSGPDPMKTY NIILRGIDMIEFPKKITKNAANLIKKLC-RDNPSERLGNLKNGVKDIQKHKWFEGFNWEG LKKGTLTPPIIPNVTSAIDTSNFDSFPEDNEDPPLDD------NSGWDVDF >A_aegypti_AAEL005754-PA -MATIKNENIQISDN----------------GGPKTNTTPASVTKGMMVTSPSVATAAAL IHPLAPLATVPLEVRDETSQNEKSVHSQPSQTSKRQPGLRAWFRKSNTCGSLYVKCSCSN GVPSGGSPQAGSEAVKGTEEGSQRHSHHH----------NTRPISTSEKDFRKIKVL--- HAFAHPDTTTVFTDQN---KYANNLSESPTRALITSAQS--GEFEIVHSTHSKRLSTPNF KADYAFHPEFVLKKLIPKSNGLSQDGKTPSISIPSPRRPVL----------KKSSRSYPG LSPSGSSVDSIERSLVHNHSASSSVDEVTEEEEQGTRRSSEEFTSSQDSYISFSANTELQ RDSFSNTNIQKLSLKYAAIKAVSDHEVQEESLTKQQEEIQLEDNSSIQDTVIQCCS---- -------DSACDS-----DNSSNTCNSSDSSPKSPPSVLQHFSRVLSSPTPGSPITSPQT PT-LDRSAQEFFIQSGILGPMGNGSSVLGRKTSKIVPNVDGPVKERCEDACGLTVSCLVL LLAAAHKIRKNSKLLFGKRTIPLSNGDRRKSIPPEHNCDSFQSYGSTPTLGSGTKSKTLE DEI----------HFLRQQLKARDEEISKL--------------KREIDKLKSVLQQTTT S------SLDRS----QNAGSGAGGT-VAPMSSP--KVLQAVEGDLLSSIQANYV----- ------------------------------------------------------------ --------------------MAGQQLPMSELYGITGKGFKLAHSSQLAGIGANDGSFR-- --------------------------------------QNK------------------- -----------GATLMAMKKQG--VSGESCE--LT-GSPS-DIKI--------------- ------------------PKYEKDYSAKQLIKDAILENDFFKN-IDSLQ-IREIVDSMYS REFR----SGEYVIHEG--QAGSHLY--VS-A--AGEFEVLK-DG------KFLGLMGPG KAFGELAILYNCTRTASI--RVLSD-SRVWVLDRRVFQQIMM--RTGLQRIEENVNFL-- RS-VPLL-KNLSNDVLTKIADVLEVEFYPAGAYIIRQGAAGDSFFLISQGTVKVTQRLPG ------CAVEEEIRILGRGEYF-G-EKALIK--EDKRTANII--AMSPGVECLTLDRESF SKHIGDLCELH--------EKDYGDEQ---------------RVLAFRNLENNNLPSS-- -------LDAVKPELMDVELMDLN------------------------------------ -----------------VV----GTLGVGGFGRVEL---VK-LERNGVVQVFALKCMKKK HIVDTKQQEHVFSERKIMLSCHSPFITRLYR--------TYRDDKFVYMLLEACLGGEVW TILRDRSYFEDSTAKFIVGCVLKAFEFLHARGIVYRDLKPENLLLDSRGYVKLVDFGFAK FIGYSSKTWTFCGTPEYVAPEIVLNKGHDRSVDYWALGVLIHELLTGIPPFAAADPMKTY NIILKGIDMVNFPKHMSRAAVSLIKRLC-RDVPTERLGYQRGGIQDIKKHKWFQGFDWEG LANQTLKSPLQPKLKGPLDMSNFDVFPAD-GHIPPDE------VSGWDEGF >T_rubripes_ENSTRUP00000002807 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------G----- ----------TL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------RDLQ YAL----------QLKIEELRQRDTLIDEL--------------ELELDQKDELIQRLQN E-------LDKY----RSVLRPATAQQ--------------------------------- ------------------------------------------------------------ --------------------VQAQ-----------------------QQSLVLQ------ ------------------------------------------------------------ ------------PDQHRSKRQA--ISAEPTA--CD-ISDLSHVTL--------------- ------------------PFYPKSPQSKEMIREAILDNDFMKN-LELSQ-IHEIVDCMYP VEYG----KDACIIEEG--DVGSLVY--VM-E--EGKVEVTK-EG------MKLCTMGPG KVFGELAILYNCTRTATV--RTLVH-VKLWAIDRQCYQTIMM--RTGLIKHAEYMDFL-- KS-VPTF-KGLPEETLSKLADVMEETHYEDGDYIIRQGARGDTFFIISNGKVNVTQEDPD ------NQGPVHLRELTRGDWF-G-ERALQG--EDVRTANVM--AAD-AVTCLVIDRDSF KHLIGGLEEVS--------NRGYEDVE---------------AKAK-------------- -------YEAENAFFSGLKLNDFN------------------------------------ -----------------IV----DTLGVGGFGRVEL---VQ-LKKE-EAKTFAMKILKKR YIVDTRQQEHIRSEKQIMSEAHCDFIVRLYR--------TFKDRKYLYMLLEACLGGELW TLLRDRGSFDDTTTRFYTGCVVEAFAYLHAKGIIYRDLKPENLLLDSHGYAKLVDFGFAK KIGLCKKTWTFCGTPEYVAPEIILNKGHDVSADYWSLGILMYELLTGSPPFSGPDPMKTY NIILRGIDMVEFPKKVTKNATNLIKKLC-RDNPSERLGNQKSGVKDIQKHKWFEGFNWEG LRKGTLTPPIRPDVSSPTDTSNFDSFPEDTDEPPPDD------NSGWDYDF >O_latipes_ENSORLP00000001301 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GNGSVKAPRAEE-----------------NSCLPSIHADA PHLDSDILRVRI------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------TYLE TEL----------ARRNQEFQTQELQLRRL----------------------------QK ELETKVSQIEKL----QDAIHSHQTVG--------------------------------- ------------------------------------------------------------ --------------------LSPTALCHHSCRHFSAIN------QGRFHKVAVE------ ------------------------------------------------------------ ------------VHRRLRAKEG--VSAEPPSADNF-LWRYRPSSVST------------- ---------------ARTVHKNSDPSTKRLINEAILSNDFLKK-LEPQH-MREMVDCMYE KVYS----EGQLVIQEG--DAGNYLY--VL-A--EGLLEVIQ-NG------KLLGEMHPG TAFGELAILYNCKRTATV--KAVLQ-SHIWTLERQTFQTIMM--QTTQARHQEYFTFL-- RS-VSLL-KQLPEEKLGRIVDCLEVEYFEKGEYIIREGEEGNTFFIIAKGQVTVTQSSEG ------FTQPQEIKTLGVGDYF-G-ERALIS--EDVRSANII--CNENDTQCLVVDRDNF NQMVGTYEELQTYLKEYVGELSKSDER---------------RHFLLSLRPHSQQSDSPE AQELSRLRERTARIPANQPFQELE------------------------------------ -----------------VI----ATLGMGGFGRVEL---VK-LKD--EESTFALKCIKKK HVVDTRQQQHIYSEKKILQQTNSSFIIRLFR--------TFRDNKYIYMLLEVCLGGELW TVLRDMSCFEEQTARFCIGCVLEAFDYLHSMGIIYRDLKPENLLLDADGYVKMADFGFAK QIGIGRKTWTFCGTPEYVAPEVIMNKGHDFGADCWSLGILVFELLTGNPPFSGSDPIKIY TMVLHGIDRVDFPKRIGKRPDDLIRRLC-KLNPVERIGNKKNGIMDIKKHKWFQGFNWEG LQGRKLPSPLKRELRGPMDHSNFDMFPPN-SEEAPDE------LSGWDKDF >A_gambiae_AGAP008585-PA -METIKRENIQLGDNRKLVATMGGPLPPSAIGATASSSTVVVRSSPTQPTPPQSVAEASV VNPVTSLCEV---VDQRQAPGEKSVHPQSPTSH------RAWFRKSNTCGSLYVQCGCTV EPGDGTQP-----------NDQQRHSDPAWSSSPPRPPVPTRPISLSDKDIRRIRPRTDK PPFIHPDSPTTVYSGAAVPHDASVRKSHPNRALVPTAQTANGDYEILHTAHSKRYSTPTI GTGYAFHPEFVLQKLGPIGD---EAGGAAQIQSPSPQSEPVRGGAAKVVFKQRSCTSYPG LAEGSEPFGA-------SFSNASSVEEVGSAVVRGQ-------DAEIGALPTLGSFEDLE RRQSVSSPPLPQQQQHQPAVTVNDTGGTLDT-TGHCRGVLIESNSNSAGKVSSACAIPAR KGRQLFVDSGSDQLSVSLDTGREAHRRSEAAHHQPGAVASCISAENSPPSPPSLLLSPVI PSKFDCSAKEYLIQSGILGPMGNGSSLLMRKTSKIVPNIDTPVKERVSASGSL--ACASG LLVNGLLIRKNSVKFWGK----VLTEDRRKSLTGQ--CDSLQSYGSSMTI-SGTEPNSLE EEL----------VGLRRLLRARDDEIDKL--------------RREIDKLKSVLQQKAI N------SLEQT----SIPSGQQRLTLTSPAGTPSHKGQHVAEGELLSSIQANYA----- ------------------------------------------------------------ --------------------MAGQ--PLSELFGISGNSFKLHQMKSVKGI---------- ------------------------------------------------------------ -------------TLQAMKKQG--VSGESCD--LM-GSQSSDIKI--------------- ------------------PKYKKDFSAKQLIKDAIMENDFFKN-IDSLQ-IREIVDSMYS REFR----KGEYVIHEG--EAGSHLY--VS-A--AGEFEVIK-DS------KVLGVMGPG RAFGELAILYNCTRTASI--RVLCD-SRVWVLDRRVFQQIMM--RTGMQRIEENVNFL-- KS-VPLL-KHLSNDVLTKIADVLEVEFYPAGAFIIRQGAAGDTFFLISQGTVKVTQRLPG ------RSVEEEIRILVRGEYF-G-EQALIR--EDKRTANII--AMSPGVECLTLDRESF TKHIGDLCELQ--------EKNYGDEE---------------RVLAFRNLENTH--PS-- -------LGSCQPELMDVNLTDLE------------------------------------ -----------------VV----GTLGVGGFGRVEL---VK-LERNGDTKVYALKCMKKR HIVDTRQQEHMYSERKIMLACQSPFICRLYR--------TYKDAKFVYMLLEACMGGEVW TILRDRVTFEDSTAKFIVACVLQAFDFLHARGIVYRDLKPENLLLDARGYAKLVDFGFSK FIGYSSKTWTFCGTPEYVAPEIILNKGHDRSVDYWALGILIHELLTGIPPFTAADPMKTY NIILKGIDMVNFPKHMSRAAVSLIKRLC-RDVPSERLGYQRGGVQDIKKHKWFQGFDWDG LIALTLKSPLQPNLLGPLDMSNFDIFPKD-LDIPPDE------LSGWDADF >O_latipes_ENSORLP00000007952 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------G----- ----------TL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------RDLQ YAL----------QEKIEELRQRDALIDEL--------------ELELDQKDELIQRLQN E-------LDKY----RSVIKPAT-QQ--------------------------------- ------------------------------------------------------------ --------------------VHKQ---------------------------NEL------ ------------------------------------------------------------ ------------HEQQRTKRQA--ISAEPTA--FD-IQDLSHVTL--------------- ------------------PFYPKSPQSKDLIKEAILDNDFMKN-LELSQ-IQEIVDCMYP VEYG----KDSCIIKEG--DVGSLVY--VM-E--DGKVEVTK-EN------LKLCTMGPG KVFGELAILYNCTRTATV--KTLTN-VKLWAIDRQCFQTIMM--RTGLIKHTEYMDFL-- KS-VPTF-HDLQEDILSKLADVLEETHYAGGEYIIRQGARGDTFFIISKGKVNVTREDLP ------NGEPVYLRSLGKGDWF-G-EKALQG--EDIRTASVI--AAE-AVTCLVIDRDSF KHLIGGLEDVS--------SKGHDDAD---------------AKAK-------------- -------YEAENAFFFSLNLADFN------------------------------------ -----------------II----DTLGVGGFGRVEL---VQ-LKSD-ENKTFAMKILKKR HIVDTRQQEHIRSEKLIMQEAHSDFIVRLYR--------TFKDSKYLYMLMEACLGGELW TILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAK KIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMFELLTGSPPFSGPDPMKTY NIILRGIDMIEFPKKITKNAGNLIKKLC-RDNPCERLGNLKNGVKDIQKHKWFEGFNWEG LKKGTLTPPIIPNVTSPVDTSNFDSFPEDNEDPPPDD------NSGWDVDF >D_rerio_ENSDARP00000071397 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GNGSMKLNPLKQVSGSAKSKNN-------GESSL--V--- ----PQVLRVRV------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------EELE THL----------KKKDEDLNAKELQIKHL--------------EEQLAQQKQTLSEISD TLRSKCLQLNKL----QDALKSQGELG--------------------------------- ------------------------------------------------------------ --------------------LLPSPL-K------EKVS------QGLTGLLRET------ ------------------------------------------------------------ ------------LNRRKGAKAG--VSAEPSSRTYD-SSGIPKFYFES------------- ------------------ARVWKEQSVKKLLTDALNKNQYLRR-LEVQQ-VKDMVECMYE RTYQ----QGEYVIKQG--EPGNHLF--VL-A--DGKLDVYQ-HN------KLLTSIAVW TTFGELAILYNCTRTASV--KAASN-VKTWALDREVFHNIMR--MTAEARHEQYRNFL-- RS-VSLL-ASLPGDKLTKIVDCLEVEYYNKGDYIIREGEEGNTFYIIANGKIKVTQSTQD ------HEEPQIINTLGKGDYF-G-EKALIS--DDVRSANII--AEEDGVECLVIDRETF SQTVGTFDELKKYLQSYVDSLARDDKK---------------RNAKRSG--SCTPPNTPV SHDMIELKERESSFASTIPFTCLE------------------------------------ -----------------AI----ATLGVGGFGRVEL---VK-LKN--ENVTFALKCIKKR HIVDNRQEEHIYSERRILLETNCPFIVKMYR--------TYKDNKYVYMLLEACLGGEIW SLLRDRGSFEEYTAKFCVGCVTEAFDYLHNNGIIYRDLKPENLMLDTDGYVKLVDFGFAK KLKCGQRTWTFCGTPEYVAPEIILNKGHGLSVDFWSLGILIFELLTGSPPFTGSDQMIIY TFILKGIEKMDFPKKITKRPGDLIRKLC-RQNPSERLGNLKNGITDIKKHRWFTGFSWSG LKARNLISPLKREVKGPTDHSYFDSYPPE-EEIPPDE------MSGWDTDF >T_rubripes_ENSTRUP00000026640 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------S----- ----------DL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------DED FAK----------ILLLKEERIRD-----L--------------ERRLADREDEIQELKR K-------LHKC----QSVL-PSA-QL--------------------------------- ------------------------------------------------------------ --------------------IGPR------------------------------------ ------------------------------------------------------------ ----------------TRRAQG--ISAEPQT--H---QDLSRQTF--------------- ------------------RKYAKSDWSKDLIKEAILDNDFMKN-LELSQ-IQEIVDCMYP VEYG----KDSCIIKEG--DVGSLVY--VM-E--DGKVEVTK-ES------LKLCTMGPG KVFGELAILYNCTRTATV--KTLTN-VKLWAIDRQCFQTIMM--RTGLIKQTEYMEFL-- KS-VPTF-QGLQEDILSKLADVLEETHYEDGEYIIRQGARGDTFFIISKGKVNVTREDSP ------SGEPVYLRSLGKGDWF-G-EKALQG--EDIRTANVI--AAE-AVTCLVIDRDSF KHLIGGLEEVS--------SKGHEDAD---------------AKAK-------------- -------YEAENAFFFNLNLADFN------------------------------------ -----------------II----DTLGVGGFGRVEL---VQ-LKSD-ENKTFAMKILKKR HIVDTRQQEHIRSEKLIMQEAHSDFIVRLYR--------TFKDSKYLYMLMEACLGGELW TILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAK KIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMFELLTGSPPFSGPDPMKTY NIILRGIDMIEFPKKITKNAANLIKKLC-RDNPSERLGNLKNGVKDIQKHKWFEGFNWEG LKKGTLTPPIIPTVTSAVDISNFDNFPEDKEDPPPDD------NSGWDVDF >X_tropicalis_ENSXETP00000046551 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GNGSMKSKPLKQPDG--------------QRVNFSISSCN KLRNADTVKNKV------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------WELE IEL----------KKKDEKLKNKEQIFQEL--------------QEQIKKQNQVIEEMAE ELQNKCVQLNKL----QVVVQTQNGISTTPDLHK--------------------M----- ------------------------------------------------------------ --------------------LQPSPT-K-TLHALPTKSLKGSPLKTFSGLFS-N------ ------------------------------------------------------------ ------------SNKRKGAKEG--VSAEPTSR-YD-GGDHPRFSFEK------------- ------------------ARVRKNTSEKILISDALNKNQFMKR-MDHHQ-IQDMVECMYE RIYL----QGEFIIRQG--EPGSQIF--VL-A--DGKAEVFQ-EN------KLLTSIPVW TTFGELAILYNCTRTASV--KAITG-VRTWALDREVFQNIMR--KTAQSKHEEYLSFL-- RAIVPLL-KELPEHKLMKIADCLELEFYEMDDYIIREGEEGSTFFIISKGKVKVTQSTEG ------YKEPQYIKFLEKGDYF-G-EKALIS--DDVRSANIL--AYGDRVECLVMDRETF NKTVGTYEELMKCLEGYVANLTLDDER---------------RHAKSPV--NERHL-RAV SMELNKMKQTLARFPSASPFENLE------------------------------------ -----------------IV----TTLGVGGFGRVEL---VK-VKN--ENLVFALKCIKKR HIVDNRQQEHIHSEKNILEEACSPFIVKLYC--------TFKDNKYVYMLLEACLGGELW SILRDRGSFDEPTAKFCTGCVTEAFEYLHQKGVLYRDLKPENLLLDSEGYVKLVDFGFAK KIFPGQKTWTFCGTPEYVAPEVILNKGHSFSVDFWSLGILLYELLTGSPPFTGPDQMIIY NLILQGIEKIEFYKNITKRPEDLIRRLC-RENPAERLGNMKNGIADIKKHRWFNGFNWEG LNTRSLPSPLKPELEGPTDHSYFDSYPPD-EEIPPDE------VSGWDQDF >X_tropicalis_ENSXETP00000039632 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LPQ ----EEARQTLN----QQKSG--------------------------------------- ------------------------------------------------------------ -----------------------------------------------SRSDSREDEI--- --------------------------------------SPPPHM---------------- ---------NSVVKGR-RRRGA--ISAEVYTEE---DAA----SYVR------------- ------------------KVIPKDYKTMAALAKAIEKNVLFAH-LDDNE-RSDIFDAMFS VTYI----AGETVIQQG--DEGDNFY--VV-D--QGEMDVYV-NN------DWMTSIGEG GSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTLRKRKMYEEFL-- SK-VSIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >G_aculeatus_ENSGACP00000013540 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------RSKEMIKDAILDNDFMKN-LELSQ-IQEVVDCMYP VDYG----KDACIIKEG--DVGSLVY--VM-E--EGKVEVTK-EG------KKLCTMGPG KVFGELAILYNCTRTATV--MTLMH-VKLWAIDRQCFQTIMM--RTGLIKHAEYMDFL-- KS-VPTF-QGLPEETLTKLADVMEETHYEEGEFIIRQGARGDTFFIISMGKVNVTQEDSA ------NQEPAHLRVLSRGSWF-G-EKALQGHSEDVRTANVI--AAE-AVSCLVIDRDSF NHLLGGLEDVS--------VRGHEDAE---------------AKAR-------------- -------YEAENTFFSSLKLKDFN------------------------------------ -----------------II----DTLGVGGFGRVEL---VQ-LKNE-EAKTFAMKILKKR HIVDTRQQEHIRSEKHIMTEAHSDFVVRLYR--------TFKDTKYLYMLMEACLGGELW TILRDRGSFEDSTTRFYTGCVVLAFAYLHAKGIIYRDLKPENLILDSRGYAKLVDFGFAK KIGFCKKTWTFCGTPEYVAPEIILNKGHDVSADYWSLGILMYELLTGSPPFSGPDPMKTY NVILRGIDMIEFPKKIPKNAASLIKKLCRRDNPSERLGNLKNGVKDIQKHKWFEGFNWEG LKKGTLTPPITPNVSSPTDTGNFDNFPEDADEPPPDD------TSGWDYDF >D_melanogaster_FBpp0077706 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------AAGMLTDREREAIV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------SNLT KDV----------QALREMVRSRESELVKL--------------HREIHKLKSVLQQTTN N-------LNVT----RNEKAKKKLYS-----------LPEQCGEQESRNQNPHL----- ------------------------------------------------------------ --------------------CSSCGMVLPTSPEFALEALSLGPLSPLASTSSASPSGR-- --------------------------------------TSADEV---------------- ---------RPKAMPAAIKKQG--VSAESCV--QS-MQQSYSIPI--------------- ------------------PKYEKDFSDKQQIKDAIMDNDFLKN-IDASQ-VRELVDSMYS KSIA----AGEFVIREG--EVGAHLY--VS-A--AGEFAVMQ-QG------KVLDKMGAG KAFGELAILYNCTRTASI--RVLSEAARVWVLDRRVFQQIMM--CTGLQRIENSVNFL-- RS-VPLL-MNLSEELLAKIADVLELEFYAAGTYIIRQGTAGDSFFLISQGNVRVTQKLTP -----TSPEETELRTLSRGDYF-G-EQALIN--EDKRTANII--ALSPGVECLTLDRDSF KRLIGDLCELK--------EKDYGDES---------------RKLAMKQAQESCRDEP-- -------KEQLQQEFPDLKLTDLE------------------------------------ -----------------VV----STLGIGGFGRVEL---VK-AHHQDRVDIFALKCLKKR HIVDTKQEEHIFSERHIMLSSRSPFICRLYR--------TFRDEKYVYMLLEACMGGEIW TMLRDRGSFEDNAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAK QIGTSSKTWTFCGTPEYVAPEIILNKGHDRAVDYWALGILIHELLNGTPPFSAPDPMQTY NLILKGIDMIAFPKHISRWAVQLIKRLC-RDVPSERLGYQTGGIQDIKKHKWFLGFDWDG LASQLLIPPFVRPIAHPTDVRYFDRFPCD-LNEPPDE------LSGWDADF >G_aculeatus_ENSGACP00000012095 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------G----- ----------TL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------RDLQ YAL----------QEKIEELRQRDALIDEL--------------ELELDQKDELIQRLQT E-------LDKY----RSVIKPAT-QV--------------------------------- ------------------------------------------------------------ --------------------V-KQ---------------------------NDL------ ------------------------------------------------------------ ------------HEQQRTKRQA--ISAEPTA--FD-IQDLSHVTL--------------- ------------------PFYPKSPQSKDLIKEAILDNDFMKN-LELSQ-IQEIVDCMYP VEYG----KDSCIIKEG--DVGSLVY--VM-E--DGKVEVTK-ES------LKLCTMGPG KVFGELAILYNCTRTATV--KTLTN-VKLWAIDRQCFQTIMM--RTGLIKHTEYMEFL-- KS-VPTF-HGLQEDILSKLADVLEETHYGDGEYIIRQGARGDTFFIISKGKVNVTREDLP ------NIEPVYLRSLGKGDWF-G-EKALQG--EDIRTANVI--AAE-AVTCLVIDRDSF KHLIGGLEEVS--------SKGHEDAD---------------AKAK-------------- -------YEAENAFFFNLNLADFN------------------------------------ -----------------II----DTLGVGGFGRVEL---VQ-LKSD-ENKTFAMKILKKR HIVDTRQQEHIRSEKLIMQEAHSDFIVRLYR--------TFKDSKYLYMLMEACLGGELW TILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAK KIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMFELLTGSPPFSGPDPMKTY NIILRGIDMIEFPKKITKNAGNLIKKLCSRDNPSERLGNLKNGVKDIQKHKWFEGFNWEG LKKGTLTPPIVPNVTSAVDTSNFDSFPEDNEDPPPDD------NSGWDVDF >O_latipes_ENSORLP00000021688 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------LIIKAIQKNDFLSR-LDEEQ-IAMMVDLLRA SNFK----PGEEVIIEG--CEGDSMY--IV-A--AGELIVTQ-AG------QDLRTLSIG DVFGELAILYNCKRTATV--KAKTQ-VRLWCMERQTYRTIIT--NKSKKRRGQLMGFL-- KT-SRTL-KNLNDVQLSKIIDSMEEVKYQDKEVIVREGAEANSFYIILKGEVLVTKNVNG --------YQKQIRRMGKGEHF-G-EQALIR--EVLRTATCT--ADGP-VTCLSIDKDSF --------CVL--------LLLTPADS-------------------KVMQEAETPAKS-- ------LPSSTLRFKDLVPVLYQE------------------------------------ ----------------GRFQGDPVTLGVGGFGRVEL---VNLAFH--HGKYYAMKRVSKK QIVAKRQEEHMLFEKKILKAIQCDFIVRLYS--------TFKDTRYIYMVMDFCSGGEIW TKLKEVGRFDEPIAVFCTACVVEAYAYLHKKNIMYRDLKPENLMLDQRGYIKLVDFGFAK ELMRGDKTYSFVGTPEYMAPEIIKNQGHDFAVDFWSLGILIFELLAGSPPFSSSEPQKIY AKILDGE--LKYPPYMNEAAKSIISKLC-RPRPGQRLGNTKNGIKEVRHHRWFGNMNWHK LRLGQLEAPTVRLIRKGPCYINFDRFPVD-HTKADED------FSGWDRDF >A_carolinensis_ENSACAP00000010068 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GNGSVKHKYLKRQEG--------------HAGNCP-P--- ----RYILRSKV------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------WELE REL----------KRQEEELHERNYHILEL--------------QDQLAKQTRTIADLTE ELKCKCIQLNKL----QDVVDTQGTNP--------------------------------- ------------------------------------------------------------ --------------------FLFSPL-KEVP-----KV------SPVP-----C------ ------------------------------------------------------------ ------------SNRRKGAKEG--VSAEPTSRTYD-LTEQPRFSFEK------------- ------------------ARVRKASSEKKLITEALSRNQFLKR-LDPQQ-IRDMVECMYG RTYQ----QGSYIIKQG--EPGNHIF--VL-A--EGKVEVFQ-QN------KLLSSIPVW TAFGELAILYNCTRTASV--KAVTI-VKTWALDREVFQNIMR--RTAQARHDQYRNFL-- RS-VSLL-KNLPEDKLSKIVDCLEVEYYDKGDYIIREGEEGNTFFVIAKGKVKVTQTTDG ------QPQTQLIKTLQKGDYF-G-ERALIS--DDVRSANII--ADENDVECLVVDRETF NQTVGTFEELQAYLAGYVATLARDDEK---------------RNAQVS---SLERLPSDV SLEMIQLKEKVAQFPSSCPFQNLE------------------------------------ -----------------IV----ATLGVGGFGRVEL---VK-LKN--ESIAFAMKCIKKK HIVDTKQQEHIHSEKRILEEACSPFIVRLYR--------TFKDNKYVYMLLEACLGGELW SILRDRGSFDETTTKFCVGCVTEAIEYLHCISVIYRDLKPENLILDAHGYIKLVDFGFAK KIAIGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGADQMTTY NLILKGVERLDFPRIVSKRPEDLIRRLC-RQNPTERLGNLKNGIHDIKRHRWLNGFNWEG LKARKLSSPLKRELSGPMDYSYFDRYPPD-QGIPPDE------LSGWDKDF >G_aculeatus_ENSGACP00000013490 -L---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EELKQQLQKQCMINQELQRQNKDL-------EQRLQEKERLLQELNG QYDELGVP-SQS----GNVVE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------PEIRKSRAAV--IASEPLPETLEI-R---------------------- ------------------KRVKKVASETSLIVKAIQKNDFLSR-LDDEQ-TAMMVDLLAV SSYK----PNDDVIKEG--TEGDSMY--IV-A--AGELLVTQ-AG------QTLRSLTTG DVFGELAILYNCRRTATV--KAKTA-VRLWCMERQTYRTIIT--NKSKKKREQLLGFL-- KT-SRTL-KELNDVQLSKIIDSMEEVKYQDKDVIVREGAEANAFYIILKGEVLVTKNVNG --------HQKQIRRMGKGEHF-G-EQALIR--EVLRTATCS--AEGP-VTCLSIDKEVF EETI----PIE--------HLELFDD---------------------------------- -------PGSTLRFKDLVPVLYQE------------------------------------ ----------------GRYQGDPVTLGVGGFGRVEL---VT-TVN--HEEYYAMKRVSKK HIVAKRQEEHMLFEKKILKATQCNFIVSLHA--------AFKDTRYIYMVMEFCVGGEIW TKLKEVGRFDEPIAMFCTACVVEAYAYLHKKNIMYRDLKPENLMLDIKGYVKLVDFGFSK EMVHGDKTYSFVGTPEYMAPEIIKNQGHDFAVDFWSLGVLIYELLVGSPPFSSSEPQKIY AKILDGV--LKYPPYMSEAARSIISKMC-RPRPGQRLGNTKNGIRDVRNHRWFSSMNWHK LRVGQLDAPTVRLIRKGPCYINFDRFPLD-QTKAEEE------FSGWDRDF >G_gallus_ENSGALP00000017721 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GNASMKHKHLRQPDR--------------HVANLALG--- ------CASHRV------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------LELE KEL----------KRKDEELQEGQSLVAEL--------------QEQLSVQTKVIAELTK ELQSKCIQLNKL----QDVINTQGEHS--------------------------------- ------------------------------------------------------------ --------------------LQPSPF-RVTP-------------KNQI-----S------ ------------------------------------------------------------ ------------ADRRKGAKEG--VSAEPTTQLYD-SSKQARFSFEK------------- ------------------SRVRKDSSEKKLITDALNKNQFLKR-LEPQQ-IREMVECMYE RTFQ----QGSYVIRQG--EPGNHIF--VL-K--EGRLEVFQ-QN------KLLSSIPVW TAFGELAILYNCTRTASV--KAITN-VKTWALDREVFQNIMR--VTAQTRQEQYRNFL-- RS-VSLL-KNLPEDKLTKIMDCLEVEYYNKGDYVIREGEEGNTFFIIAKGKVKVTQSTAD ------HSQPQLIKNLHKGDYF-G-EKALIS--DDVRSANVI--ADEYDVECLVIDRDTF NQTVGTYEELQTYLEGYVANLARADEK---------------RHAKRRS--FCGQSTKEV SLEMIQLKEKVAQFPSS-PFQNLE------------------------------------ -----------------VV----TTLGVGGFGRVEL---VK-VKN--ENVAFAMKCIKKK HVVDTKQQEHIYSEKKILEQICSPFIVKLYR--------TFKDSKYVYMLLEACLGGELW SLLRDRGCFDEPTTKFCVGCVTEALDYLHHIGIVYRDLKPENLILDAEGYIKLVDFGFAK KIGSGQKTWTFCGTPEYVAPEVILSKGHDFSVDFWSLGILVYELLTGSPPFSGADQMTTY NLILKGIEKLDFPRTITRRPEDLIRRLC-RQNPTERLGNLRNGINDIKKHRWLNGFNWDG LKLRKLASPLKRELSGPTDYSYFDSYPPE-EGMPPDE------LSGWDKDF >M_musculus_ENSMUSP00000073268 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------G----- ----------TL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------RDLQ YAL----------QEKIEELRQRDALIDEL--------------ELELDQKDELIQKLQN E-------LDKY----RSVIRPAT-QQ--------------------------------- ------------------------------------------------------------ --------------------AQKQ-------------------------SASTL------ ------------------------------------------------------------ ------------QGEPRTKRQA--ISAEPTA--FD-IQDLSHVTL--------------- ------------------PFYPKSPQSKDLIKEAILDNDFMKN-LELSQ-IQEIVDCMYP VEYG----KDSCIIKEG--DVGSLVY--VM-E--DGKVEVTK-EG------VKLCTMGPG KVFGELAILYNCTRTATV--KTLVN-VKLWAIDRQCFQTIMM--RTGLIKHTEYMEFL-- KS-VPTF-QSLPDEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGQVNVTREDSP ------SEDPVFLRTLGKGDWF-G-EKALQG--EDVRTANVI--AAE-AVTCLVIDRDSF KHLIGGLDDVS--------NKAYEDAE---------------AKAK-------------- -------YEAEAAFFANLKLSDFN------------------------------------ -----------------II----DTLGVGGFGRVEL---VQ-LKSE-ESKTFAMKILKKR HIVDTRQQEHIRSEKQIMQGAHSDFIVRLYR--------TFKDSKYLYMLMEACLGGELW TILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAK KIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTY NIILRGIDMIEFPKKIAKNAANLIKKLC-RDNPSERLGNLKNGVKDIQKHKWFEGFNWEG LRKGTLTPPIIPSVASPTDTSNFDSFPEDSDEPPPDD------NSGWDIDF >G_gallus_ENSGALP00000006027 -L---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------G----- ----------TL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------RDLQ YAL----------QEKIEELRQRDALIDEL--------------ELELDQKDDLIPKLQN K-------L-VY----RSVIRPAA-RQ--------------------------------- ------------------------------------------------------------ --------------------AQQQ-------------------------SARSL------ ------------------------------------------------------------ ------------QGEQRTKRQA--ISAEPTA--FD-IQDLSHVTL--------------- ------------------PFYPKSPQSKELIKEAILDNDFMKN-LELSQ-IQEIVDCMYP VEYG----KDSCIIKEG--DVGSLVY--VM-E--DGKVEVTK-EG------VKLCTMGPG KVFGELAILYNCTRTATV--KTLVN-VKLWAIDRQCFQTIMM--RTGLIKHTEYMEFL-- KS-VPTF-QSLPEEILSKLADVLEETHYESGEYIIRQGARGDTFFIISKGKVNVTREDSP ------SEDPVFLRTLGKGDWF-G-EKALQW--EDVRTANVI--AAE-AVTCLVIDRDSF KHLIGGLDDVS--------NKAYEDAE---------------AKAK-------------- -------YEAEAAFFANLKLSDFN------------------------------------ -----------------II----DTLGVGGFGRVEL---VQ-LKSE-ETKTFAMKILKKR HIVDTRQQEHIRSEKQIMQSAHSDFIVRLYR--------TFKDSKYLYMLMEACLGGELW TILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAK KIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTY NIILRGIDMIEFPKKIAKNAANLIKKLC-RDNPSERLGNLKNGVKDIQKHKWFEGFNWEG LRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDD------NSGWDIDF >M_mulatta_ENSMMUP00000014212 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------G----- ----------TL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------RDLQ YAL----------QEKIEELRQRDALIDEL--------------ELELDQKDELIQKLQN E-------LDKY----RSVIRPAT-QQ--------------------------------- ------------------------------------------------------------ --------------------AQKQ-------------------------SASTL------ ------------------------------------------------------------ ------------QGEPRTKRQA--ISAEPTA--FD-IQDLSHVTL--------------- ------------------PFYPKSPQSKDLIKEAILDNDFMKN-LELSQ-IQEIVDCMYP VEYG----KDSCIIKEG--DVGSLVY--VM-E--DGKVEVTK-EG------VKLCTMGPG KVFGELAILYNCTRTATV--KTLVN-VKLWAIDRQCFQTIMM--RTGLIKHTEYMEFL-- KS-VPTF-QSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSP ------SEDPVFLRTLGKGDWF-G-EKALQG--EDVRTANVI--AAE-AVTCLVIDRDSF KHLIGGLDDVS--------NKAYEDAE---------------AKAK-------------- -------YEAEAAFFANLKLSDFN------------------------------------ -----------------II----DTLGVGGFGRVEL---VQ-LKSE-ESKTFAMKILKKR HIVDTRQQEHIRSEKQIMQGAHSDFIVRLYR--------TFKDSKYLYMLMEACLGGELW TILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAK KIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTY NIILRGIDMIEFPKKIAKNAANLIKKLC--DNPSERLGNLKNGVKDIQKHKWFEGFNWEG LRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDD------NSGWDIDF >H_sapiens_ENSP00000363092 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------G----- ----------TL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------RDLQ YAL----------QEKIEELRQRDALIDEL--------------ELELDQKDELIQKLQN E-------LDKY----RSVIRPAT-QQ--------------------------------- ------------------------------------------------------------ --------------------AQKQ-------------------------SASTL------ ------------------------------------------------------------ ------------QGEPRTKRQA--ISAEPTA--FD-IQDLSHVTL--------------- ------------------PFYPKSPQSKDLIKEAILDNDFMKN-LELSQ-IQEIVDCMYP VEYG----KDSCIIKEG--DVGSLVY--VM-E--DGKVEVTK-EG------VKLCTMGPG KVFGELAILYNCTRTATV--KTLVN-VKLWAIDRQCFQTIMM--RTGLIKHTEYMEFL-- KS-VPTF-QSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSP ------SEDPVFLRTLGKGDWF-G-EKALQG--EDVRTANVI--AAE-AVTCLVIDRDSF KHLIGGLDDVS--------NKAYEDAE---------------AKAK-------------- -------YEAEAAFFANLKLSDFN------------------------------------ -----------------II----DTLGVGGFGRVEL---VQ-LKSE-ESKTFAMKILKKR HIVDTRQQEHIRSEKQIMQGAHSDFIVRLYR--------TFKDSKYLYMLMEACLGGELW TILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAK KIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTY NIILRGIDMIEFPKKIAKNAANLIKKLC-RDNPSERLGNLKNGVKDIQKHKWFEGFNWEG LRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDD------NSGWDIDF >P_troglodytes_ENSPTRP00000004326 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------G----- ----------TL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------RDLQ YAL----------QEKIEELRQRDALIDEL--------------ELELDQKDELIQKLQN E-------LDKY----RSVIRPAT-QQ--------------------------------- ------------------------------------------------------------ --------------------AQKQ-------------------------SASTL------ ------------------------------------------------------------ ------------QGEPRTKRQA--ISAEPTA--FD-IQDLSHVTL--------------- ------------------PFYPKSPQSKDLIKEAILDNDFMKN-LELSQ-IQEIVDCMYP VEYG----KDSCIIKEG--DVGSLVY--VM-E--DGKVEVTK-EG------VKLCTMGPG KVFGELAILYNCTRTATV--KTLVN-VKLWAIDRQCFQTIMM--RTGLIKHTEYMEFL-- KS-VPTF-QSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSP ------SEDPVFLRTLGKGDWF-G-EKALQG--EDVRTANVI--AAE-AVTCLVIDRDSF KHLIGGLDDVS--------NKAYEDAE---------------AKAK-------------- -------YEAEAAFFANLKLSDFN------------------------------------ -----------------II----DTLGVGGFGRVEL---VQ-LKSE-ESKTFAMKILKKR HIVDTRQQEHIRSEKQIMQGAHSDFIVRLYR--------TFKDSKYLYMLMEACLGGELW TILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAK KIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTY NIILRGIDMIEFPKKIAKNAANLIKKLC-RDNPSERLGNLKNGVKDIQKHKWFEGFNWEG LRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDD------NSGWDIDF >T_guttata_ENSTGUP00000002960 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GNRLVKPKHLRQPNR--------------HMANLAIG--- ----SDVLCSKV------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------LELE KEL----------KRKDQQLQESQHHVAEL--------------QEQLAMQTKVIAELSN ELQSKCIQLNKL----QDVISTQGEHS--------------------------------- ------------------------------------------------------------ --------------------LQPSPF-KV------------------------S------ ------------------------------------------------------------ ------------ADRRRGAKEG--VSAEPTTALCD-LSRQTMFSLEK------------- ------------------ATVQKDSSEKKLITDALNRNQFLKR-LEPHQ-TRDMVECMYE RTFQ----QGSYVIRQG--EPGNHIF--VL-K--EGSLEVFQ-QN------KLLSSIPVW TAFGELAILYNCTRTASV--KAITN-VKTWALDREVFQNIMR--VTAQTRQEQYRKFL-- RS-VSLL-KNLPEDKLTKIMDCLEVEYYDKGDYVIREGEEGNTFFIIAKGKVIVTQSTTD ------HSQPQVIKNLHKGDYF-G-EKALIS--DDTRSANVI--ADEYNVECLVIDRETF NQTVGTYEELQTYLEGYVANLAQADEK---------------RHAKGRS--FCGQLTKEV SLEMIELKEKVAQFPPS-PFQNLE------------------------------------ -----------------VV----TTLGVGGFGRVEL---VK-VKN--ENMAFAMKCIKKK HVVDTKQQEHIYSEKKILEQICSPFVVKLYR--------TFKDNKYVYMLLEACLGGELW SLLRDRGSFDEFTTKFCVGCVTEAFDYLHQIGIIYRDLKPENLILDAEGYIKLVDFGFAK KIGSGQKTWTFCGTPEYVAPEVILSKGHDFSVDFWSLGILVYELLTGSPPFSGADQMMTY NLILKGIEKLDFPKVITRRPEDLIRRLC-RQNPTERLGNLRNGINDIKKHRWLSGFNWDS LKVRKLTSPLKRELSGPTDYSYFDSYPPE-VGSPPDE------LSGWDKDF >M_mulatta_ENSMMUP00000026112 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GNGSVKPKHSKHPDG--------------HSGNL--T--- ----TDALRNKV------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------TELE REL----------RRKDAEIQEREYNLKEL--------------REQLSKQTVAIAELTE ELQNKCIQLNKL----QDVVHMQGGSP--------------------------------- ------------------------------------------------------------ --------------------LQASPD-K-VPLEVHRKT------SGLV-----S------ ------------------------------------------------------------ ------------LHSRRGAKAG--VSAEPTTRTYD-LNKPPEFSFEK------------- ------------------ARVRKDSSEKKLITDALNKNQFLKR-LDPQQ-IKDMVECMYG RNYQ----QGSYIIKQG--EPGNHIF--VL-A--EGRLEVFQ-GE------KLLSSIPMW TTFGELAILYNCTRTASV--KAITN-VKTWALDREVFQNIMR--RTAQARDEQYRNFL-- RS-VSLL-KNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEG ------HDQPQLIKTLQKGEYF-G-EKALIS--DDVRSANII--AEENDVACLVIDRETF NQTVGTFEELQKYLEGYVANLNRDDEK---------------RHAKRSM--SNWKLSKAL SLEMIQLKEKVARFSSSSPFQNLE------------------------------------ -----------------II----ATLGVGGFGRVEL---VK-VKN--ENVAFAMKCIRKK HIVDTKQQEHVYSEKRILEELCSPFIVKLYR--------TFKDNKYVYMLLEACLGGELW SILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAK KIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGIDQMMTY NLILKGIEKMDFPRKITRRPEDLIRRLC-RQNPTERLGNLKNGINDIKKHRWLNGFNWEG LKARSLPSPLQRELNGPIDHSYFDKYPPE-KGMPPDE------LSGWDKDF >H_sapiens_ENSP00000264399 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GNGSVKPKHSKHPDG--------------HSGNL--T--- ----TDALRNKV------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------TELE REL----------RRKDAEIQEREYHLKEL--------------REQLSKQTVAIAELTE ELQNKCIQLNKL----QDVVHMQGGSP--------------------------------- ------------------------------------------------------------ --------------------LQASPD-K-VPLEVHRKT------SGLV-----S------ ------------------------------------------------------------ ------------LHSRRGAKAG--VSAEPTTRTYD-LNKPPEFSFEK------------- ------------------ARVRKDSSEKKLITDALNKNQFLKR-LDPQQ-IKDMVECMYG RNYQ----QGSYIIKQG--EPGNHIF--VL-A--EGRLEVFQ-GE------KLLSSIPMW TTFGELAILYNCTRTASV--KAITN-VKTWALDREVFQNIMR--RTAQARDEQYRNFL-- RS-VSLL-KNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEG ------HDQPQLIKTLQKGEYF-G-EKALIS--DDVRSANII--AEENDVACLVIDRETF NQTVGTFEELQKYLEGYVANLNRDDEK---------------RHAKRSM--SNWKLSKAL SLEMIQLKEKVARFSSSSPFQNLE------------------------------------ -----------------II----ATLGVGGFGRVEL---VK-VKN--ENVAFAMKCIRKK HIVDTKQQEHVYSEKRILEELCSPFIVKLYR--------TFKDNKYVYMLLEACLGGELW SILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAK KIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTY NLILKGIEKMDFPRKITRRPEDLIRRLC-RQNPTERLGNLKNGINDIKKHRWLNGFNWEG LKARSLPSPLQRELKGPIDHSYFDKYPPE-KGMPPDE------LSGWDKDF >P_troglodytes_ENSPTRP00000027855 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GNGSVKPKHSKHPDG--------------HSGNL--T--- ----TDALRNKV------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------TELE REL----------RRKDAEIQEREYHLKEL--------------REQLSKQTVAIAELTE ELQNKCIQLNKL----QDVVHMQGGSP--------------------------------- ------------------------------------------------------------ --------------------LQASPD-K-VPLEVHRKT------SGLV-----S------ ------------------------------------------------------------ ------------LHSRRGAKAG--VSAEPTTRTYD-LNKPPEFSFEK------------- ------------------ARVRKDSSEKKLITDALNKNQFLKR-LDPQQ-IKDMVECMYG RNYQ----QGSYIIKQG--EPGNHIF--VL-A--EGRLEVFQ-GE------KLLSSIPMW TTFGELAILYNCTRTASV--KAITN-VKTWALDREVFQNIMR--RTAQARDEQYRNFL-- RS-VSLL-KNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEG ------HDQPQLIKTLQKGEYF-G-EKALIS--DDVRSANII--AEENDVACLVIDRETF NQTVGTFEELQKYLEGYVANLNRDDEK---------------RHAKRSM--SNWKLSKAL SLEMIQLKEKVARFSSSSPFQNLE------------------------------------ -----------------II----ATLGVGGFGRVEL---VK-VKN--ENVAFAMKCIRKK HIVDTKQQEHVYSEKRILEELCSPFIVKLYR--------TFKDNKYVYMLLEACLGGELW SILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAK KIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTY NLILKGIEKMDFPRKITRRPEDLIRRLC-RQNPTERLGNLKNGINDIKKHRWLNGFNWEG LKARSLPSPLQRELKGPIDHSYFDKYPPE-KGMPPDE------LSGWDKDF >E_caballus_ENSECAP00000022043 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GNGSVKPKHSKHPDG--------------HSGNL--T--- ----TDALQSKV------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------TELE REL----------RRKDAEIQEREYHLKEL--------------REQLSKQTVAIAELTE ELQNKCIQLNKL----QDVLHMQGGSP--------------------------------- ------------------------------------------------------------ --------------------LQASPD-K-VPLEVHRKT------SGLV-----S------ ------------------------------------------------------------ ------------LHSRRGAKAG--VSAEPTTRTYD-LNKPPEFSFEK------------- ------------------ARVRKDSSEKKLITDALNKNQFLKR-LDPQQ-IKDMVECMYG RNYQ----QGSYIIKQG--EPGNHIF--VL-A--EGQLEVFQ-GE------KLLSSIPMW TTFGELAILYNCTRTASV--KAITN-VKTWALDREVFQNIMR--RTAQARDEQYRNFL-- RS-VSLL-KNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEG ------HDQPQLIKTLQKGEYF-G-EKALIS--EDVRSANII--AEENDVACLVIDRETF NQTVGTFEELQKYLEGYVANLNRDDEK---------------RHAKRSM--SNWKLSKAL SLEMIQLKEKVARFSSSSPFQNLE------------------------------------ -----------------II----ATLGVGGFGRVEL---VK-VKN--ENVAFAMKCIRKK HIVDTKQQEHVYSEKRILEELCSPFIVKLYR--------TFKDNKYVYMLLEACLGGELW SILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAK KIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGIDQMMTY NLILKGIEKMDFPRKITRRPEDLIRRLC-RQNPTERLGNLKNGINDIKRHRWLNGFNWEG LKARNLPSPLQRELSGPTDHSYFDKYPPE-KGVPPDE------LSGWDKDF >D_melanogaster_FBpp0088350 -MRFCFDRLCFATKRPAQNSNSNAPHSSTTVDAPPRPADVDVATVPVATPAPPPQQPVSN LFYADYQKLQPAIIDRDWERDRDTDTDTRSEAKPPDIVEHIEPVEEQRQIHTQIQSPAEI QIQIPPTPPAPSIQIQIQQRYRRHSSAEDRNLNTRRNDSNITEALRKAASMQQEPNANYQ FPTDLGLVSIVNNNNNTNTHPSGSNSGSNNNSNINNNLVGGIVTLPAAGGLIGLEHTASG LRLIPAPPTHSDVLTHTLIYGTPPSGAQQLNQDPRSLLHQQELQLQQRYQQLQQLQAQTQ GLYTSQGSPVLYHQPSPGSSQPVAIPGATCHSPTQLQPPNTLNLQQQMQSLRISGCTPSG TGGSATPSPVGL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------VDPN FIVSNYVAASPQEERFIQIIQAKELKIQEM--------------QRALQFKDNEIAELKS H-------LDKF----QSVFPFSRGSA--------------------------------- ------------------------------------------------------------ ----------------------AGCAGTGGASGSGAGGSGGSGPGTATGATRKS------ ------------------------------------------------------------ -----------GQNFQRQRALG--ISAEPQS--ES-SLLLEHVSF--------------- ------------------PKYDKDERSRELIKAAILDNDFMKN-LDLTQ-IREIVDCMYP VKYP----AKNLIIKEG--DVGSIVY--VM-E--DGRVEVSR-EG------KYLSTLSGA KVLGELAILYNCQRTATI--TAITE-CNLWAIERQCFQTIMM--RTGLIRQAEYSDFL-- KS-VPIF-KDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQD ------TQEEKFIRMLGKGDFF-G-EKALQG--DDLRTANIICESAD-GVSCLVIDRETF NQLISNLDEIK--------HRYDDEGA---------------ME---------------- -------RRKINEEFRDINLTDLR------------------------------------ -----------------VI----ATLGVGGFGRVEL---VQ-TNGD-SSRSFALKQMKKS QIVETRQQQHIMSEKEIMGEANCQFIVKLFK--------TFKDKKYLYMLMESCLGGELW TILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAK KLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTY NIILKGIDAIEFPRNITRNASNLIKKLC-RDNPAERLGYQRGGISEIQKHKWFDGFYWWG LQNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGPPPDD------VTGWDKDF >P_pygmaeus_ENSPPYP00000016617 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GNGSVKPKHSKHPDG--------------HSGNL--T--- ----TDALRNKV------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------TELE REL----------RRKDAEIQEREYHLKEL--------------REQLSKQTVAIAELTE ELQNKCIQLNKL----QDVVHMQGGSL--------------------------------- ------------------------------------------------------------ --------------------LQASPD-K-VPLEVHRKT------SGLV-----S------ ------------------------------------------------------------ ------------LHSRRGAKAG--VSAEPTTRTYD-LNKPPEFSFEK------------- ------------------ARVRKDSSEKKLITDALNKNQFLKR-LDPQQ-IKDMVECMYG RNYQ----QGSYIIKQG--EPGNHIF--VL-A--EGRLEVFQ-GE------KLLSSIPMW TTFGELAILYNCTRTASV--KAITN-VKTWALDREVFQNIMR--RTAQARDEQYRNFL-- RS-VSLL-KNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEG ------HDQPQLIKTLQKGEYF-G-EKALIS--DDVRSANII--AEENDVACLVIDRETF NQTVGTFEELQKYLEGYVANLNRDDEK---------------RHAKRSM--SNWKLSKAL SLEMIQLKEKVARFSSSSPFQNLE------------------------------------ -----------------II----ATLGVGGFGRVEL---VK-VKN--ENVAFAMKCIRKK HIVDTKQQEHVYSEKRILEELCSPFIVKLYR--------TFKDNKYVYMLLEACLGGELW SILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAK KIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTY NLILKGIEKMDFPRKITRRPEDLIRRLC-RQNPTERLGNLKNGINDIKKHRWLNGFNWEG LKARSLPSPLQRELNGPIDHSYFDKYPPE-KGMPPDE------LSGWDKDF >B_taurus_ENSBTAP00000003877 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GNGSVKPKHSKNPDG--------------HPGNL--T--- ----ASALRSRV------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------TELE REL----------RRKDAEIQEREYHLKEL--------------REQLSKQTVAIAELTE ELQNKCIQLNKL----QDVVHLQGGSL--------------------------------- ------------------------------------------------------------ --------------------PRASPD-K-VPLEVQRKT------SGLV-----S------ ------------------------------------------------------------ ------------LHSRRGAKAG--VSAEPTTRTYD-LNKPPEFSFEK------------- ------------------ARVRKDSSEKKLITDALNKNQFLKR-LDPQQ-IKDMVECMYG RNYQ----QGSYIIKQG--EPGNHIF--VL-A--EGRLEVSQ-GE------KLLSSIPMW TTFGELAILYNCTRTASV--KAITN-VKTWALDREVFQNIMR--RTAQARDEQYRNFL-- RS-VSLL-KNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEG ------HDQPQLIKTLQKGEYF-G-EKALIS--EDVRSANII--AEENDVACLVIDRETF NQTVGTFEELQKYLEGYVANLNRDDEK---------------RHAKRSM--SSWKLSKAL SLEMIQLKEKVARFSSSSPFQNLE------------------------------------ -----------------II----ATLGVGGFGRVEL---VK-VKN--ENVAFAMKCIRKK HIVDTKQQEHVYSEKKILEELCSPFIVKLYR--------TFKDNKYVYMLLEACLGGELW SILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAK KIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGIDQMMTY NLILKGIEKMDFPRKITRRPEDLIRRLC-RQNPTERLGNLKNGINDIKKHRWLNGFNWEG LKARNLPSPLQRELSGPTDHSYFDKYPPE-RGVPPDE------LSGWDKDF >A_aegypti_AAEL013214-PA -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------HLIDRLVPGSYIVA HWFDPVRLSRRIYEQEFNPIANGTSRTVGKFSPKGTERESGLGSLDERLNLPNGTPWEAR PVSVPQPQFERKTPLPTVKDRISA------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------SSQE ------PDRNVNFELLKEIQQTKILLQLALESKLREHPNN--DDRHQLVKLEKEIKELQN R---ISKSTIVPEPVQESVIVRQNAHPTARASPQPSHGPPRPNLPPPKSSLSRQISTIPT QAWEASETSDDYDTIPPSKSKVQSVPEVTSSEEEDEDEEIPD------------TQDDTS QDEEPTPPKLPPPRVP----SMVDDMISLSVPLSMVSNEIEKAQQAPPVPSGPPPKRMPP PTPEKEVTLGTPTQRDSEDSLPPPK------------IEELNSS---------------- ---------RTAGILKKVRKEG--VLSDKTE-----VKGSREIVI--------------- ------------------PSHPKRTDDELLIRKAITANEFLNNLMDEER-LKAVTDAMSP MTFP----PNSYIIKEG--DIGAHFF--VS-A--DGTYEVVA-EN------KVIKSFGRG VVFGELAILYKAKRFASI--RVTTE-AKVWMLERKVFQKIMM--KSGRKEREENVKFL-- ST-VSIL-KDLQTEKLHKISDLLKREFYATGSTIIQQGDPGDKFYIIRGGSVNVIKTDR- ------HGVDKLVGTLQRGAYF-G-EQALLH--EDRRLASII--ANPPGTECLTLNRIAF NEFLGGLEQLR--------EIKLSDDL---------------PRISG------------- -------DKNTSSEYDHIQLHDLT------------------------------------ -----------------YI----GTLGIGGFGRVEL---VR-YQ---KQKTFALKYLKKI EMVRQQQQEHAYSEKDIMLSCNSPFIVRLYK--------TYRDKKYLYFLMEACLGGDVW TILQKSKHFDERTARFMAGCVVEAFEYLHSRNMIYRDLKPENLMLDEQGYIKLVDFGFAK RIGANQKTWTFAGTPEYVSPEIILNKGHDRAVDYWALGVFIHELLVGKPPFRGKNHMKTY NAILRGIDIIELPSRIPKKAQVLIKRLC-RQIPAERLGYGKNGIADIKNHPWFSGFEWQR LKERTLPAPLVRPIQSDTDLSNFDEYPKD-QDEPPDE------TSGWDINF >M_musculus_ENSMUSP00000031277 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GNGSVKPKHAKHPDG--------------HSGNL--S--- ----NEALRSKV------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------LELE REL----------RRKDAELQEREYHLKEL--------------REQLAKQTVAIAELTE ELQSKCIQLNKL----QDVIHVQGGSP--------------------------------- ------------------------------------------------------------ --------------------LQASPD-K-VPLDVHRKT------SGLV-----S------ ------------------------------------------------------------ ------------LHSRRGAKAG--VSAEPTTRTYD-LNKPPEFSFEK------------- ------------------ARVRKDSSEKKLITDALNKNQFLKR-LDPQQ-IKDMVECMYG RNYQ----QGSYVIKQG--EPGNHIF--VL-A--EGRLEVFQ-GE------KLLSSIPMW TTFGELAILYNCTRTASV--KAITN-VKTWALDREVFQNIMR--RTAQARDEEYRNFL-- RS-VSLL-KNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEG ------HDQPQLIKTLQKGEYF-G-EKALIS--DDVRSANII--AEENDVACLVIDRETF NQTVGTFDELQKYLEGYVATLNRDDEK---------------RHAKRSM--SSWKLSKAL SLEMIQLKEKVARFSSTSPFQNLE------------------------------------ -----------------II----ATLGVGGFGRVEL---VK-VKN--ENVAFAMKCIRKK HIVDTKQQEHVYSEKRILEELCSPFIVKLYR--------TFKDNKYVYMLLEACLGGELW SILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDADGYLKLVDFGFAK KIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGIDQMMTY NLILKGIEKMDFPRKITRRPEDLIRRLC-RQNPTERLGNLKNGINDIKKHRWLNGFNWEG LKARSLPSPLRRELSGPIDHSYFDKYPPE-KGVPPDE------MSGWDKDF >A_gambiae_AGAP009798-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------PSSPPQSTTVVSTVVKSNERESGLGSLDERLNITGNATANDT NRELPDPIASR--PRDSEKAKISC------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------SSRE TSTIEPPTKQGQEQLLKDLLQNKILHMLAIQSKGYSQLSK--SERATLVRLEEEIQELQK KSKAPEKPQQLPQPTNEPKKTEQDRRNSANSYETNLPPLTMPSVIEQSVTKSDNRTEEPL QDGEMS----DYDVIPGQKPNDEVVPEAPSSEDDRSTVLPPDLPPRLSRVNNVEEADDTS QDEEPTPPKLPPPRSQLEQNLAVDEMLSRSLQETIIRQSAREDEKEIPLPTAPPPSREPP PIPSSD---QQTIDNDPQATTPPRKEMLRKVSSQRSLIEELDSK---------------- -----------IGTLKKTRKQG--VVSDKTD-----LKESKDIVI--------------- ------------------PTHPKSPDTELLIKTAIVANDFLNNMMDEER-LQAVTAAMSS MTFP----PNSYIIKEG--DIGAHFF--VS-E--EGTYEVVV-DN------KVIKSFGRG VVFGELAILYKAKRFASI--RVTTG-ARVWLLERKVFQKIMM--KSGRKEREENVRFL-- ST-VSVL-KDLEIEKLHKISDLLKREFYATGSTIIQQGDPGDKFYIIRGGSVNVIKTDK- ------KGNDRLVGTLQRGAYF-G-EQALLH--EDRRLASII--ANPPGTECLTLNRIAF NEFLGGLEKLR--------EVKLSDTI---------------PRSST------------- -------MTNIVSEYDHIQLHDLT------------------------------------ -----------------YI----GTLGIGGFGRVEL---VQ-YK---NHQTFALKYLKKI EMVRQQQQEHAYSEKDIMLSCNSPFIVRLYK--------TYRDKKYLYFLMEACLGGDVW TVLQKSKFFDERTARFITGCVVEAFEYLHSRNMIYRDLKPENLMLDEKGYIKLVDFGFAK RIGPNQKTWTFAGTPEYVSPEIILNKGHDRAVDYWALGVLIHELLVGKPPFRGKNHMKTY NAILRGIDIIELPSRVPKKAQVLIKRLC-RQTAAERLGYGKNGIADIKNHPWFGSFEWQK LKERTMPAPLIRPIVSDIDLSNFDEYPKD-QDEPPDE------TSGWDINF >G_gorilla_ENSGGOP00000006462 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------EKKLITDALNKNQFLKR-LDPQQ-IKDMVECMYG RNYQ----QGSYIIKQG--EPGNHIF--VL-A--EGRLEVFQ-GE------KLLSSIPMW TTFGELAILYNCTRTASV--KAITN-VKTWALDREVFQNIMR--RTAQARDEQYRNFL-- RS-VSLL-KNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEG ------HDQPQLIKTLQKGEYF-G-EKALIS--DDVRSANII--AEENDVACLVIDRETF NQTVGTFEELQKYLEGYVANLNRDDEK---------------RHAKRSM--SNWKLSKAL SLEMIQLKEKVARFSSSSPFQNLE------------------------------------ -----------------II----ATLGVGGFGRVEL---XX-XXX--XXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXLYR--------TFKDNKYVYMLLEACLGGELW SILRDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPPFSGVDQMMTY NLILKGIEKMDFPRKIXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXWLNGFXWEG LKARSLPSPLQRE-------------------------------------- >R_norvegicus_ENSRNOP00000003237 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GNGSVKPKHSKHPDG--------------QSGNL--S--- ----NEALRSKV------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------AELE REV----------KRKDAELQEREYHLKEL--------------REQLAKQTVAIAELTE ELQSKCIQLNKL----QDVIHVQGGSP--------------------------------- ------------------------------------------------------------ --------------------LQASPD-K-VPLDVHRKT------SGLV-----S------ ------------------------------------------------------------ ------------LHSRRGAKAG--VSAEPTSRTYD-LNKPPEFSFEK------------- ------------------ARVRKDSSEKKLITDALNKNQFLKR-LDPQQ-IKDMVECMYG RNYQ----QGSYIVKQG--EPGNHIF--VL-A--EGRLEVFQ-GE------KLLSSIPMW TTFGELAILYNCTRTASV--KAITN-VKTWALDREVFQNIMR--RTAQARDEEYRNFL-- RS-VSLL-KNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEG ------HDQPQLIKTLQKGEYF-G-EKALIS--DDVRSANII--AEENDVACLVIDRETF NQTVGTFDELQKYLEGYVATLNRDDEK---------------RHAKRSM--SSWKLSKAL SLEMIQLKEKVARFSSTSPFQNLE------------------------------------ -----------------II----ATLGVGGFGRVEL---VK-VKN--ENIAFAMKCIRKK HIVDTKQQEHVYSEKRILEELCSPFIVKLYR--------TFKDNKYVYMLLEACLGGELW SILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDADGYLKLVDFGFAK KIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGIDQMMTY NLILKGIEKMDFPRKITRRPEDLIRRLC-RQNPTERLGNLKNGINDIKKHRWLNGFNWEG LKARSLPSPLRRELSGPIDHSYFDKYPPE-KGVPPDE------MSGWDKDF >O_latipes_ENSORLP00000000450 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------PGSL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------RDLQ LAL----------QLKVEELRQRDALIDEL--------------ELELDSKDDLIRQLQV E-------LDRY----RSTARRGGQDV--------------------------------- ------------------------------------------------------------ -----------------------------------------AYAQKKAYATLYA------ ------------------------------------------------------------ ------------IETRRTKRHA--FSAEAPP--LD-SAQLAAVSI--------------- ------------------TSYRKSKESRDLIQKALLDNDYMKH-LEREQ-IASIVDSMYP TSLD----KGSCVTQEG--DVGSTLY--VL-E--EGRVEVTK-QG------RKRSNISGG KVFGELAVLQRCACTATV--TALTN-VRLWAMDRQGFQTVTM--RAGLLRRSRHTDLL-- RR-VPWF-QSLPDGVLCRLAEALEETVYSDGDFIIRQGAPGDTFFIVSEGQVKASQQASA ------DGERETEWTLSEGDWF-G-EHALKG--EDVRAASVM--AVG-GATCLVIDRESF KRVVGGPDGGP--------DGAPDGGD----------------------------VGSDG GAEVEFRQRVESDFISGLSLGHFR------------------------------------ -----------------II----STLGRGGCSRVDL---VQ-LEKY-PNRSFALKVLQRS RILQTGQQNRVRSERRILMEAHNPFIVRLYR--------TFRDSRRLYMLLEACLGGDLW SLLQDRGPFDDGATRFYAGCVTEALVYLHHKGIIYRNLKPETILLDLRGYAKLVDFGFAK YVGVGKKTWTFCGTPEYVAPEILLNKGHDGSVDCWALGVLLFELLCGSPPFLASDPLDIY NIILRGIDMIQFPRKITKSAANLIKGLC-RDRPSERLGNQKNGLRDVQKHKWFDGFDWDG LQQGSIRPPFAPPADGPLVHSDFDSFTEDTDEPPPDD------GSGWDAEF >D_rerio_ENSDARP00000090593 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------G----- ----------TL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------RDLQ YAL----------QEKIEELRQRDALIDEL--------------ELELDQKDELIQKLQN E-------LDKY----RSVIRPAT-QQ--------------------------------- ------------------------------------------------------------ --------------------VQTR---------------------------SEL------ ------------------------------------------------------------ ------------PEHQRTKRQA--ISAEPA----N-IQQLSHVTL--------------- ------------------PNVPKSAKSKDLIKSAILDNDFMKN-LEMSQ-IQEIVDCMYP VDYD----KNSCIIKEG--DVGSLVY--VM-E--DGKVEVTK-EG------LKLCTMGPG KVFGELAILYNCTRTATV--RTVSS-VKLWAIDRQCFQTIMM--RTGLIKHAEYMELL-- KS-VLTF-RGLPEEILSKLADVLEETHYEDGNYIIRQGARGDTFFIISKGKVTMTREDCP ------GQEPVYLRSMGRGDSF-G-EKALQG--EDIRTANVI--AAE-TVTCLVIDRDSY KHLIGGLEDVS--------NKGCEDAE---------------AKAK-------------- -------YEAENAFFSNLNLSDFN------------------------------------ -----------------II----DTLGVGGFGRVEL---VQ-LKSD-EMKTFAMKILKKR HIVDTRQQEHIRSEKLIMQEAHSDFIVRLYR--------TFKDSKYLYMLMEACLGGELW TILRDRGNFDDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAK KIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTY NIILRGIDMIEFPKKITKNAANLIKKLC-RDTPSERLGNLKNGVKDIQKHKWFEGFNWDG LRKGTLMPPIIPNVTSSTDTSNFDSFPEDNEDPPPDD------NSGWDIDF >T_nigroviridis_ENSTNIP00000019469 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PETLEITR---------------------- ------------------ARVKKNSSEANLIVKAIQKNDFLSR-LDDEQ-TAMMVDLLAV SNFK----PGSHVIKEG--SEGDSMY--IV-A--GGQLQVTQ-AG------RDLRTLTTG DVFGELAILYNCKRTATVTDSAKTA-VRLWCMERQTYRTIIT--NKSKKRREQLMGFL-- KM-SQTL-KDLNNVQLSKIIDSMEEVKYQDKDVIVREGAEANTFYIILKGEVLVTKNVNG --------HQKQIRRMGKGEHF-G-EQALIR--EVLRTATCT--ADGP-VTCFTIDKEVF EETI----PVE--------HLELFDDS-------------------KVLQEARAPAKSSK QFCLSTSPSSTLRFKDLVPVLYQE------------------------------------ ----------------GRYQGDPVTLGVGGFGRVEL---MT-TVN--HGMYYAMKRVSKK HIVAKRQEEHMLFEKKILKAIQCDFIVRLHA--------TFKDTRYVYMIMEFCGGGEIW TKLKEVGRFDEPMAVFCAACVVEAFAYLHKKSIMYRDLKPENLMLDAKGYVKLVDFGFAK EMVRAEKTYSFVGTPEYMAPEIIKNQGHDFAVDFWSLGILIFELLAGSPPFSSSEPQKIY AKILDGV--LKYPPYLSEASKSIISKLC-RPRPGQRLGNTKNGIKDVRHHRWFSSINWHK LRMSQLDAPTVRLIRKGPCYINFDRFPVD-HTKVEEE------FSGWDQDF >T_rubripes_ENSTRUP00000001539 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GNASMKSKRYKNADGSVTASNSWSHRDGRRLKNA--S--- ----LESLRVRV------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------EELE REG----------KRRNEELQAKEQQIRSL--------------QEQLARQTRVLAELSE ELQTKCIQLSKL----QDVMKSQGGAG--------------------------------- ------------------------------------------------------------ --------------------TASRPT-S-V-RKAGKSS------PNLSVRIKET------ ------------------------------------------------------------ ------------LNRRKGAKAG--VSAEPTS------SSLPKFCFEK------------- ------------------ARVAKDNSVKKLLTDALNKNQYLRR-LELQQ-IKDIVECMYE RTYQ----RGEYVVKQG--EPGNHLF--VLAA--DGTLDVFQ-HN------KLLTSITVW TTFGELAILYNCTRTASV--RAVND-VRTWALDREVFQNIMR--RTAEMRHEQYRNFL-- RS-VSLL-ANLPEDKLSKMVDCLEVEYYDKGEFIIREGEEGSTFYIIAQGKVKVTQTTEA ------HTFPQVINTLQKGDYF-G-EKALVS--DDVRSASIL--AEENGVECLVIDRETF DQTVGTFSELQKHLQGYVATLDRDDRK---------------RHARKKS--VSRHQSQPL SSDAICLKEMVSTFSASRPFDHLE------------------------------------ -----------------VV----ATLGVGGFGRVEL---VK-MQD--KDVAFALKIIKKK HVVDNRQEEHIHSERKILAEARSPFIVKLYR--------TFKDNKYVYMLLEACLGGEVW SLLRDRGNFEEPTAKFCVGCVTEAFDYLHRKGILYRDLKPENLLLDAEGYIKLVDFGFAK KIRCGQKTWTFCGTPEYVAPEIILNKGHNFSVDFWSLGILVFELLTGSPPFSGSDQMMTY TFILKGIEKMDFPKKITKRPEDLIRKLC-RQNPAERLGNLKNGITDIKKHRWFNGFSWEG LKAKTLPSPLKRALTGPTDHSYFDSYPPD-EDSPPDE------LSGWDVDF >D_rerio_ENSDARP00000092292 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------IVKAIGKNDFLRR-LDEEQ-ISMMVDLMKV LDCR----AGDEIIKEG--TEGDSMY--IV-A--AGELKVTQ-AG------RDLRILSPG DMFGELAILYNCKRTASV--KAISA-VKLWCIERQTYRSIMT--NKSKMKREQLMGFL-- KT-ARTL-KALNDVQLSKIIDSMEEVRFQDNEVIVREGAEGNTFYIILKGEVLVTKKVNG --------QQKTIRKMGEGEHF-G-ELALIR--EILRTATCT--AVGV-VICFSIDKDHY TSGVEGLLEIR--------HTESSCQA---------------QVQVHVIYDAKNSASH-- -------SQNKLHFK--------------------------------------------- -------------------IGDPVTLGIGGFGKVEL---VT-TLE--HRKYFAMKRISKQ HVVAKKQEAHILLEKKILQAIRCDFIVRLHA--------AFKDSRYVYMIMEFCPGGEIW TKLKEAGRFEEKIAVFITACVVEAYAYLHNKGILYRDLKPENLMLDSKGYVKLVDFGFAK ELSRGEKTYSFCGTPEYISPEIIQNQGHDIAADFWSLGVLIYELLVGSPPFSSSEPQKIY AKILDGV--LNFPSYMGEGAKSIISKLC-RLRPGQRLGNTKNGIKDVRHHRWFNSINWHK LRMGQLEAPTVRLIRKGPCYINFDRFPYD-KTQAEEE------FSGWDCDF >C_familiaris_ENSCAFP00000013072 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GNGSVKPKHPKHPDG--------------HPGNL--S--- ----THALRSKV------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------VELE REL----------RRKEAEIQEREYHLKEL--------------REQLSRQTAAVAELTE ELQNKCIQLNKL----QDVVHLQGGSL--------------------------------- ------------------------------------------------------------ --------------------PQASPD-K-VPLEVHRKA------SGLV-----S------ ------------------------------------------------------------ ------------LHSRRGAKAG--VSAEPTSRTYD-LNKPPEFSFEK------------- ------------------ARVRKDSSEKKLITDALNKNQFLKR-LDPQQ-IKDMVECMYG RNYQ----QGSYIIKQG--EPGNHIF--VL-AVIEGRLEVFQ-GE------KLLSSIPLW TTFGELAILYNCTRTASV--KALTN-VKTWALDREVFQNIMR--RTAQARDEQYRNFL-- RS-VSLL-KNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEG ------HDQPQVIKTLQKGEYF-G-EKALIS--EDVRSANII--AEENDVACLVIDRETF NQTVGTFEELQKYLEGYVANLNRDDEK---------------RHAKRSM--SNWKLSKAL SLEMIQLKEKVARFSSSSPFQNLE------------------------------------ -----------------II----ATLGVGGFGRVEL---VK-VKN--ENVAFAMKCIRKK HIVDTKQQEHVYSEKRILEELCSPFIVKLYR--------TFKDNKYVYMLLEACLGGELW SILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDADGYLKLVDFGFAK KIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGIDQMMTY NLILKGIEKMDFPRKITRRPEDLIRRLC-RQNPTERLGNLKNGINDIKKHRWLNGFNWEG LKARNLPSPLQRELSGPTDHSYFDKYPPE-KGVPPDE------LSGWDKDF >A_aegypti_AAEL007826-PA -MSSPKPAMAGGSKNGTSSHSGGRNNGKLQSDSGNGRSIEDTV----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------LSLRRELREVYETLREKNEQ LVQLEKDVRDRDISIRYLKNEFKKLKDYYSCSKSDLSIPPSFNLNGNGKSAGDGG----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SLE DLL----------QKVQKECKEKDLQIRELNQKVIRLSNNLIYVQKESLSKDDRIDELQN E-------IDKF----RQVVRPITKAM--------------------------------- ------------------------------------------------------------ --------------------IEKRCSEETYDSFS---------PGIENTRVLPV------ ------------------------------------------------------------ ------------NHEPRMKRQA--ISAEPLS-----SLAGMQGDL--------------- ------------------IKIPKSSLSREIIKSAILDNDFMKN-LEMTQ-IREIVDCMYP VQYG----AGSLIIKEG--DVGSIVY--VM-E--EGRVEVSR-EG------KYLSTLSGA KVLGELAILYHCQRTATI--TAATD-CKLWAVERQCFQTIMM--RTGLIRQAEYSDFL-- KS-VPIF-KNLPEDTLGKISDVLEECYYQKGDYIIRQGARGDTFFIISKGQVRVTIRQPD ------TQEEKFIRTLGKGDFF-G-EKALQG--DDLRTANIICDSPE-GVTCLVIDRDTF NQLISNLDEIK--------NRYNDDAV---------------SE---------------- -------KKKIYEEFRDVRLTDLR------------------------------------ -----------------VI----ATLGVGGFGRVEL---VQ-LAQD-KARSFALKQMKKS QIVETRQQQHIMSEKEIMSEANSDFIVKLFK--------TFKDRKYLYMLMESCLGGELW TILRDRGHFDDGTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLDVSGYVKLVDFGFAK KLQSGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGADPMRTY NIILKGIDAIEFPRNITRNASVLIKKLC-RDNPTERLGYQRGGISEIQKHKWFDGFYWEG LRNRSLPPPILPKVQSVVDTANFDDYPADPDGPPPDD------LSGWDEDF >T_rubripes_ENSTRUP00000032043 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EELKQQLEKQCLINKELQRQNKDL-------EKRLQEKEKLLQNLQS QYHDLVFQISLL----SPLMR--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------LTPRSGRAVR--LSSPPSPSTRRWRLLAPGS----------------- ------------------RKIPALTSEANLIVKAIQKNDFLSR-LDDEQ-TAMMVELLAV SSFK----PGDHVIKEG--TEGDSMY--IV-A--GGELRVTQ-AG------RDLRTLTTG DVFGELAILYNCKRTATV--TAKTA-VRLWCMERQTYRTIIT--NKSKKRREQLMGFL-- KM-SRTL-KDLNDVQLSKIIDSMEEVKYQDKDVIVREGAEANTFYIILKGEVLVTKNVNG --------HQKQIRRMGKGEHF-G-EQALIR--EVLRTATCS--ADGP-VTCLSIDKERA --------HIS--------FCLFAPSS-------------------KVLQEAQAPPKS-- --------SKEIVFEETIPVEHLE------------------------------------ -----------------VF----DELGVGGFGRVELHSKMT-TVN--HGMYYAMKRVSKK HIVAKRQEEHMLFEKKVLKAIQCDFIVRLHA--------TFKDTCYVYMIMEFCGGGEIW TKLKEVGRFDEPTAVFCTACVVEAFAYLHKKSVMYRDLKPENLMLDVKGYVKLVDFGFAK EMVRGEKTYSFVGTPEYMAPEIIKNQGHDFAVDFWSLGILIFELLAGSPPFSSSEPQKIY AKILDGV--LKYPPYLSEASKSIISKLC-RPRPGQRLGNTKNGIKDVRHHRWFSSINWHK LRMSQLDAPTVRLIRKGPCYINFDRFPVD-HTKAEED------FSGWDREF >M_domestica_ENSMODP00000025995 -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GNGSVKPKQSKIPDG--------------HAGKLSGT--- ----IDALRSKV------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------TELE REL----------KKKDDELQQREYHLREL--------------QEKLSKQTIALAEITE ELQNKCIQLNKL----QDVVNIQGGNS--------------------------------- ------------------------------------------------------------ --------------------LLFSPY-K-VPLQVNRRT------SGLV-----S------ ------------------------------------------------------------ ------------LHSRRGAKEG--VSAEPTTRTF------AEFSFEK------------- ------------------ARVRKDSSDKKLITDALNKNQFLKR-LDPQQ-IKDMVECMYG RNYP----QGSYIIKQG--EPGNHIF--VL-A--EGRLEVFQ-GN------KLLSSIPMW TTFGELAILYNCTRTASV--KAISN-VKTWALDREVFQNIMR--RTAQARDEQYRQFL-- RS-VCLL-KNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGVVKVTQSTEG ------YDQPQLIKTLKKGDYF-G-EKALIS--DDVRSANII--AEENDVACLVIDRETF SQTVGTFEELQKYLEGYVANLNRDDEK---------------RHAKRSM--SGWRQTKAL SLEMIQLKEKVAKFSSSSPFQNLE------------------------------------ -----------------IV----TTLGVGGFGRVEL---VK-VKN--ENVAFAMKCIRKK HIVDTKQQEHIYSEKKILEEMCSPFIVKFYR--------TFKDRKYVYMLLEACLGGELW SILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAK KIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGIDQMMTY NLILKGIEKIDFPKKITRRPEDLIRRLC-RQNPTERLGNLKNGINDIKRHRWLNGFNWEG LKARSLPSPLKRELSGPIDHSYFDNYPPE-KGIPPDE------LSGWDKDF