>H_sapiens_ENSP00000265717 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IEIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------AGLTELLQGFTVEVLRHQPA-DLL--------------EFALQHFTR-- -------LQQ----ENERKGTARFGHEGRTWGDLGA-AA-------GGGTPSKGVNFAEE ---PMQ-----------------SDSEDG---EEEEAAPA---------DAGAFN----- --------------------APVINR-FTRR-AS--VCAEAYNPDEE-EDD----AESR- ------------------------------IIHPKTDDQRNRLQEACKDILLFKNL-DPE Q-MSQVLDAMFEKLVK----DGEHVIDQG--DDGDNFY--VI-D--RGTFDIYV-KC--D GVGRCVGNYDNRGSFGELALMYNTPRAATI--TATSP-GALWGLDRVTFRRIIV--KNNA KKRKMYESFI--ES-LPFL-KSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVE SGEVKITMKRKGKSEVE-ENGAVEIARCSRGQYF-G-E-LALVTNKPRAASAHAIGT--V KCLAMDVQAFERLLGPCMEIM--------KRNIATY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVALF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GTNM------------------------------- ---------------------------------------------------DIVEPTA >P_troglodytes_ENSPTRP00000047706 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IEIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------AGLTELLQGFTVEVLRHQPA-DLL--------------EFALQHFTR-- -------LQQ----ENERKGTARFGHEGRTWGDLGA-AA-------GGGTPSKGVNFAEE ---PMH-----------------SDSEDG---EEEEAAPA---------DAGAFN----- --------------------APVINR-FTRR-AS--VCAEAYNPDEE-EDD----AESR- ------------------------------IIHPKTDDQRNRLQEACKDILLFKNL-DPE Q-MSQVLDAMFEKLVK----DGEHVIDQG--DDGDNFY--VI-D--RGTFDIYV-KC--D GVGRCVGNYDNRGSFGELALMYNTPRAATI--TATSP-GALWGLDRVTFRRIIV--KNNA KKRKMYESFI--ES-LPFL-KSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVE SGEVKITMKRKGKSEVE-ENGAVEIARCSRGQYF-G-E-LALVTNKPRAASAHAIGT--V KCLAMDVQAFERLLGPCMEIM--------KRNIATY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVALF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GTNM------------------------------- ---------------------------------------------------DIVEPTA >M_mulatta_ENSMMUP00000020202 -X---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IEIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------AGLTELLQGFTVEVLRHQPA-DLL--------------EFALQHFTR-- -------LQQ----ENERKGTARFGHEGRTWGDAGA-SA-AA---VGGGTPSKGVNFAEE ---PMH-----------------SDSEDG---EEEEAAPA---------DAGAFN----- --------------------APVINR-FTRR-AS--VCAEAYNPDEE-EDD----AESR- ------------------------------IIHPKTDDQRNRLQEACKDILLFKNL-DPE Q-MSQVLDAMFEKLVK----DGEHVIDQG--DDGDNFY--VI-D--RGTYDIYV-KC--D GVGRCVGNYDNRGSFGELALMYNTPRAATI--TATSP-GALWGLDRVTFRRIIV--KNNA KKRKMYESFI--ES-LPFL-KSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVE SGEVKITMKRKGKSEVE-ENGAVEIARCSRGQYF-G-E-LALVTNKPRAASAHAIGT--V KCLAMDVQAFERLLGPCMEIM--------KRNIATY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVALF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GTNM------------------------------- ---------------------------------------------------DIVEPTA >C_familiaris_ENSCAFP00000005888 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IEIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------AGLTELLQGFTVEVLRHQPA-DLL--------------DFALQHFTR-- -------LQQ----ENERRGAARFGHEARTWGDAGA-AA-------GGGTPSKGVNFAEE ---PAR-----------------TDSEDA----EEEEEAA---------DAGAFN----- --------------------APVINR-FTRR-AS--VCAEAYNPDEE-EDD----AESR- ------------------------------IIHPKTDDQRNRLQEACKDILLFKNL-DPE Q-MSQVLDAMFEKLVK----EGEHVIDQG--DDGDNFY--VI-D--RGTFDIYV-KC--D GVGRCVGNYDNRGSFGELALMYNTPRAATI--TATSP-GALWGLDRVTFRRIIV--KNNA KKRKMYESFI--ES-LPFL-KSLEVSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVE SGEVKITMKRKGKSEVE-EDGAVEIARCSRGQYF-G-E-LALVTNKPRAASAHAIGT--V KCLAMDVQAFERLLGPCMEIM--------KRNIATY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVALF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GTNM------------------------------- ---------------------------------------------------DIVEPTA >R_norvegicus_ENSRNOP00000012415 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IEIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------AGLTELLQGFTVEVLRHQPA-DLL--------------EFALQHFTR-- -------LQQ----ENERKGAARFGHEGRTWGDAGA-AA-------GGGTPSKGVNFAEE ---PMR-----------------SDSENG-----EEEEAA---------EAGAFN----- --------------------APVINR-FTRR-AS--VCAEAYNPDEE-EDD----AESR- ------------------------------IIHPKTDDQRNRLQEACKDILLFKNL-DPE Q-MSQVLDAMFEKLVK----EGEHVIDQG--DDGDNFY--VI-D--RGTFDIYV-KC--D GVGRCVGNYDNRGSFGELALMYNTPRAATI--TATSP-GALWGLDRVTFRRIIV--KNNA KKRKMYESFI--ES-LPFL-KSLEVSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVE SGEVRITMKRKGKSDIE-ENGAVEIARCLRGQYF-G-E-LALVTNKPRAASAHAIGT--V KCLAMDVQAFERLLGPCMEIM--------KRNIATY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVALF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GTNM------------------------------- ---------------------------------------------------DIVEPTA >B_taurus_ENSBTAP00000019916 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IEIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------AGLTELLQGFTVEVLRHQPA-DLL--------------EFALQHFTR-- -------LQE----ENERKGAARFGHEGRTWGDAGA-AS-------GGGTPSKGVNFAEE ---PRH-----------------SDSENG---EEEEEEAA---------DAGAFN----- --------------------APVINR-FTRR-AS--VCAEAYNPDEE-EDD----AESR- ------------------------------IIHPKTDDQRNRLQEACKDILLFKNL-DPE Q-MSQVLDAMFEKLVK----EGEHVIDQG--DDGDNFY--VI-D--RGTFDIYV-KC--D GVGRCVGNYDNRGSFGELALMYNTPRAATI--TATSP-GALWGLDRVTFRRIIV--KNNA KKRKMYESFI--ES-LPFL-KSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVE SGEVKITMKRKGKSEVE-ENGAVEIARCSRGQYF-G-E-LALVTNKPRAASAHAIGT--V KCLAMDVQAFERLLGPCMEIM--------KRNIATY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVALF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GTNM------------------------------- ---------------------------------------------------DIVEPTA >M_musculus_ENSMUSP00000003079 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IEIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------AGLTELLQGFTVEVLRHQPA-DLL--------------EFALQHFTR-- -------LQQ----ENERKGAARFGHEGRTWGDAGA-AA-------GGGIPSKGVNFAEE ---PMR-----------------SDSENG-----EEEEAA---------EAGAFN----- --------------------APVINR-FTRR-AS--VCAEAYNPDEE-EDD----AESR- ------------------------------IIHPKTDDQRNRLQEACKDILLFKNL-DPE Q-MSQVLDAMFEKLVK----EGEHVIDQG--DDGDNFY--VI-D--RGTFDIYV-KC--D GVGRCVGNYDNRGSFGELALMYNTPRAATI--TATSP-GALWGLDRVTFRRIIV--KNNA KKRKMYESFI--ES-LPFL-KSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVE SGEVKITMKRKGKSEVE-ENGAVEIARCFRGQYF-G-E-LALVTNKPRAASAHAIGT--V KCLAMDVQAFERLLGPCMEIM--------KRNIATY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVALF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GTNM------------------------------- ---------------------------------------------------DIVEPTA >P_pygmaeus_ENSPPYP00000020060 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IEIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------AGLTELLQGFTVEVLRHQPA-DLL--------------EFALQHFTR-- -------LQQ----ENERKGTARFGHEGRIWGDVGA-AA-------GGGTPSKGVNFAEE ---PMH-----------------SDSEDG---EEEEAAPA---------DAGAFN----- --------------------APVINR-FTRR-AS--VCAEAYNPDEE-EDD----AESR- -----------------------------------------------------------E Q-MSQVLDAMFEKLVK----DGEHVIDQG--DDGDNFY--VI-D--RGTFDIYV-KC--D GVGRCVGNYDNRGSFGELALMYNTPRAATI--TATSP-GALWGLDRVTFRRIIV--KNNA KKRKMYESFI--ES-LPFL-KSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVE SGEVKITMKRKGKSEVE-ENGAVEIARCSRGQYF-G-E-LALVTNKPRAASAHAIGT--V KCLAMDVQAFERLLGPCMEIM--------KRNIATY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVALF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GTNM------------------------------- ---------------------------------------------------DIVEPTA >M_domestica_ENSMODP00000020466 -S---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IEIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------AGLTELLQSFTVEVLRHQPG-DLL--------------EFALQHFTR-- -------LQQ----ENRYKG----GHGAVDRASAGAGAV-------GGGTPSRGVNFADE ---PVQ-----------------TESENG---EEEDDDEE---------QQSGDT----- --------------------APVLNR-FTRR-AS--VCAEAYNPDEE-EDD----AESR- ------------------------------IIHPKTDDQRNRLQEACKDILLFKNL-DPE Q-MSQVLDAMFEKLVK----EGEHVIDQG--DDGDNFY--VI-D--RGTYDIYV-KC--D GVGKCIGNYDNRGSFGELALMYNTPRAATI--TATSP-GALWGLDRVTFRRIIV--KNNA KKRRMYESFI--ES-LPFL-KSLEVSERLKVVDVIGTKVYKDGEQIIAQGDSADSFFIIE SGEVKISMKRKNKQEVE-ENGAIEIARYSRGQYF-G-E-LALVTNKPRAASAHAIGT--V KCLAMDVQAFERLLGPCMEIM--------KRNIANY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVALF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GTNM------------------------------- ---------------------------------------------------DI----- >A_carolinensis_ENSACAP00000014732 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------ISVP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EGLTELLQGFTVEVLRSQPG-DLL--------------DFALQYFGR-- -------LKA----EEEENGEADVGRLHA--ASPGT-PR-------GKQAPRGGVNFAEE ---PMQ-----------------TDSESG---EGDED--G---------EAEGFP----- --------------------APVINR-FTRR-AS--VCAEAYNPDEE-EDD----ADSK- ------------------------------IIHPKTDDQRNRLQEACKDILLFKNL-DPE Q-MSQVLDAMFEKSVE----GGEHVIDQG--DDGDNFY--VI-D--WGTYDIYV-KC--E GVGRCVGTYDNRGSFGELALMYNTPRAATI--IATSP-GAVWGLDRVTFRRIIV--KNNA KKRRMYESFI--ES-LPFL-KSLELSERLKVVDVIGTKIYKDGEQIIAQGDMADCFFIIE SGEVKITMKRKGKQDVD-ENEAVEITRYTRGQYF-G-E-LALVTNKPRAASAFALGT--V KCLVRDVPAFER-LGPCMEIM--------KRNIANY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVALF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GTNM------------------------------- ---------------------------------------------------DIADPSA >O_cuniculus_ENSOCUP00000010967 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IEIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------AGLTELLQGFTVEVLRHQPA-DLL--------------EFALQHFTR-- -------LQQ----ENERKGAARFGHEGRTWGDAGA-AA-------GGGTPSKGVNFAEE ---PAH-----------------SDSENGEEEEEEEEEAA---------DAGAFN----- --------------------APVINR-FTRR-AS--VCAEAYNPDEE-EDD----AESR- ------------------------------XXXXKTDDPRNRLQEACKDILLFKNL-DPE Q-MSQVLDAMFEKLVK----EGEHVIDQG--DDGDNFY--VI-D--RGTFDIYV-KC--D GVGRCVGNYDNRGSFGELALMYNTPRAATI--TATSP-GALWGLXXXXXXXXXX--XXXX XXXXXXXXXX--XX-XXXX-XXXXVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVE SGEVKITMKRKGKSEVE-ENGAVEIARCSRGQYF-G-E-LALVTNKPRAASAHAIGT--V KCLATLLQAFERIY-PYMEIM--------HRKKATY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------QEQLGAVL------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GEVM------------------------------- ---------------------------------------------------DIVEDHA >G_gorilla_ENSGGOP00000003850 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IEIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------AGLTELLQGFTVEVLRHQPA-DLL--------------EFALQHFTR-- -------LQQ----ENERKGTARFGHEGRTWGDVGA-AA-------GGGTPSKGVNFAEE ---PMH-----------------SDSEDG---EEEEAAPA---------DAGAFN----- --------------------APVINR-FTRR-AS--VCAEAYNPDEE-EDD----AESR- ------------------------------IIHPKTDDQRNRLQEACKDILLFKNL-DPE Q-MSQVLDAMFEKLVK----DGEHVIDQG--DDGDNFY--VI-D--RGTFDIYV-KC--D GVGRCVGNYDNRGSFGELALMYNTPRAATI--TATSP-GALWGLXXXXXXXXXX--XXXX XXXXXXXXXX--XX-XXXX-XXXXFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVE SGEVKITMKRKGKSEVE-ENGAVEIARCSRGQYF-G-E-LALVTNKPRAASAHAIGT--V KCL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >O_anatinus_ENSOANP00000005022 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DGHM--EPEKGQRR---------LPRMME----- --------------------SPVINR-FTRR-AS--VCAEAYNPDEE-EDD----AESR- ------------------------------IIHPKTDDQRTRLQEACKDILLFKNL-DPE Q-MSQVLDAMFEKLVK----EGEHVIDQG--DDGDNFY--VI-D--RGTFDIYV-KC--D GVGRCVGNYDNRGSFGELALMYNTPRAATI--TATSP-GALWGLDRVTFRRIIV--KNNA KKRRMYENFI--ES-LPFL-KSLDVSERLKVVDVIGTKIYKDGEQIIAQGDLADSFFIVE SGEVKITMKRKNKQEVE-ENDSVEIARYSRGQYF-G-E-LALVTNKPRAASAYAIGT--V KCLAMDVQAFERLLGPCMEIM--------KRNIANY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVALF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GTNM------------------------------- ---------------------------------------------------DIADP-- >T_guttata_ENSTGUP00000003190 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------FAEE ---AML-----------------TDSESGE--FEQPSPPP---------PPQQFP----- --------------------APAVNR-FTRR-AS--VCAEAYNPDEE-EDD----AESR- ------------------------------IIHPKTDDQRNRLQEACKDILLFKNL-DPE Q-MSQVLDAMFEKMVE----GGEHVIDQG--DDGDNFY--VI-D--KGTYDIYV-KC--D GVGRCVGTYDNRGCFGELALMYNTPRAATI--IATSP-GSIWGLDRVTFRRIIV--KNNA KKRRMYESFI--ES-LPFL-KSLEMSERLKVVDVIGTKVYKDGEQIIAQGDLADSFFIVE SGEVRIIMTRKGKQDLE-ENGAVEIARCSRGQYF-G-E-LALVTNKPRAASAFALGT--V KCLVMDVQAFERLLGPCMEIL--------KRNIANY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVALF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GTNM------------------------------- ---------------------------------------------------DIADTSA >X_tropicalis_ENSXETP00000013024 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IEIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EGLTELLQSFTVEVLRKQPE-DLL--------------EFALQYFTQ-- -------LKQ----SKSQGGPLSHGMELPF-------------------RLTKGVIFAEE ---PMQ-----------------TDSENG---EEEEDDDE---------EDFVGV----- --------------------RPFVPA-FHMQ--G--IGFSTLFSQAV-TEL----KLPA- ------------------------------VIYPKTDDQRNRLQEACKDILLFKSL-DQE Q-MSQVLDAMFEKLVK----CGEHVIDQG--DDGDNFY--VI-D--RGTYDIFV-KS--D GVVRCVGAYDNRGSFGELALMYNTPRAATI--VATSV-GSIWGLDRATFRRIIV--KNNA KKKRMYENFI--ES-LPFL-KSLEFSERLKVVDVIGTKTYYDGEQIIAQGDGADSFYIVE SGEVRINMKSKSKPDAE-TNEAVEIARYTRGQYF-G-E-LALVTNKPRAASAYAVGN--V KCLVMDVQAFERLLGPCMEIM--------KRNIANY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVALF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GTNM------------------------------- ---------------------------------------------------DITDPST >E_caballus_ENSECAP00000009806 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------IIHPKTDDQRNRLQEACKDILLFKNL-DPE Q-MSQVLDAMFEKLVN----EGEHVIDQG--DDGDNFY--VI-D--RGTFDIYV-KC--D GVGRCVGNYDNRGSFGELALMYNTPRAATI--TATSP-GALWGLDRVTFRRIIV--KNNA KKRKMYESFI--ES-LPFL-KSLEVSERLKVVDVIGTKVYSDGEQIIAQGDLADSFFIVE SGEVKITMKRKGKSEAE-ENGAVEIARCSRGQYF-G-E-LALVTNKPRAASAHAIGT--V KCLAMDVQAFERLLGPCMEIM--------KRNIATY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVALF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GTNM------------------------------- ---------------------------------------------------DIVEPTA >O_latipes_ENSORLP00000005487 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IEIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EGLTELLQSFTVEVLRNQPR-DLL--------------EFALQYFTQ-- -------LKD----NETKEAAFGNDQ-------------------NSAPRSGKAVNFIDE ---AMQ-----------------IDSENGE--EEEDDDDD---------DDEEFI----- --------------------APVINR-FIRR-AS--VCAEAFNPDED-EED----KEPR- ------------------------------VTYPKTDEQRQRLQEACRDILLFKNL-DPE E-ISQVLDAMFEKFCT----EGEHIIDQD--DDGDNFY--VI-E--SGTFNIFV-KV--D GIEKLVGCYDNRGSFGELALMYNTPRAATI--IATSP-GALWCLDRLTFRRIIV--KNNA KKRRLYEAFI--ET-LPLL-TSLETSERMKVVDVLSTRVYNDSQQIIAQGDLADCFYIVE SGQVRITMKRSRTKKDQ-EEEEVEIATCTRGQYF-G-E-LALVTNKPRAASAYAVGS--V KCLVMDVQAFERLLGPCMDIM--------KRNIANY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLQSLF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSSP------------------------------- ---------------------------------------------------EIEQPSA >X_tropicalis_ENSXETP00000020557 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IEIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PGLTDLLQGYTVEVLRQKPP-DLV--------------EFAIQYFTR-- -------LKE----KQLQDGAGA----------------------GSLRPHARVVNFDGE ---PMQ-----------------TESNGDE--EEDEEDD----------DDSDFE----- --------------------PPVINR-YSRR-VS--VCAEAYNPDEE-DED----TEPR- ------------------------------VVRPKTDEQRCRLQEACKDILLFKNL-DQE Q-LSQVLDAMFEMRVK----PQEHVIDQG--DDGDNFY--VV-E--RGQYDIFV-ER--D GQSRCVGRYDNHGSFGELALMYNTPRAATI--VATSE-GALWGLDRVTFRRIIL--KNNA KKRKTYEIFI--ES-VPVL-KFLELSERMKIVDVIAARVYKDGDRIIAQGDKADCFFIVE SGEVKIMMKSKTKTGQE-SNQEVEIARCKSGQYF-G-E-LALVTNKPRAASAYAVGD--V KCLIMDVQAFERLLGPCMDIM--------KRNITHY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVALF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSSM------------------------------- ---------------------------------------------------DLRDPGK >G_aculeatus_ENSGACP00000013289 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IEIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EGLTELLQSFTVEVLRNQPR-DLL--------------EFALQYFTQ-- -------LKE----RETTQASFGNDQ-------------------NSAPRPVKAVNFIDE ---AMQ-----------------MDSENGE--ELVDI------------YTYASA----- --------------------APVINR-FIRR-AS--VCAEAFNPDDD-DED----KEPW- ------------------------------VIHPKTDDQRQRLQEACWDILLFKNL-DPE E-MSQVLDAMFEKFCT----EGEHIIDQD--DDGDNFY--VI-E--SGTFKIFV-KV--D GTDKLVGCYDNRGSFGELALMYNTPRAATI--IATSP-GALWCLDRLTFRRIIV--KNNA KKRRVYEAFI--ET-LPLL-TSLELSERMKVVDVISTKTYSDSQQIIAQGDLADCFYIVE SGQVRITMKRSRTKKDQ-EDEEMDIATCMRGQYF-G-E-LALVTNKPRAASAYAVGS--V KCLAMDVQAFERLLGPCMDIM--------KRNIANY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVTLF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSST------------------------------- ---------------------------------------------------GMEQQSA >T_guttata_ENSTGUP00000009429 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IEIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PGLTELLQGYTVEVLRHRPS-DLL--------------GFAAEYFAR-- -------LRD----ARDQEAGGG----------------------------RRGRFPAGQ ---GGQ-----RAGIEWGRGSAGSRSPAPPLPGRCRSAPGAPHA-----PSLGPE----- --------------------SPVVNR-YNRR-VS--VCAEAFNPDEE-EED----TEQR- ------------------------------VVHPKTDEQRCRLQEACKDILLFKNL-DQE Q-LSQVLDAMFERKVK----PQEHVIDQG--DDGDNFY--VV-E--RGVYDIVV-AK--D NQSRCVGRYDNHGSFGELALMYNTPRAATI--VATTE-GALWGLDRVTFRRIIL--KNNA KKRKTYELFI--ES-VPLL-KSLEPSERMKIVDVIGEKVYQDGERIISQGDKADCFYIVE SGEVKILIKSKGNSVKE-ANQEVEIARCHRGQYF-G-E-LALVTNKPRAASAYAVGE--V KCLVMDVQAFERLLGPCMDIM--------KRNITHY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVAMF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSSM------------------------------- ---------------------------------------------------DLMDPGN >G_gallus_ENSGALP00000011344 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IEIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PGLTELLQGYTVEVLRHRPA-DLV--------------GFAADYFTR-- -------LRD----AREQEATGD---------------------------GRRVISFDGE ---PMQ-----------------TESNGEEEPERGDEE-----------SDSDFE----- --------------------PPVINR-YNRR-VS--VCAEAFNPDEE-EED----TEQR- ------------------------------IVHPKTDEQRCRLQEACKDILLFKNL-DQE Q-LSQVLDAMFERKVK----PHEHVIDQG--DDGDNFY--VI-E--EGLYDIVV-AK--D NQARCVGRYDNHGSFGELALMYNTPRAATI--VATTE-GALWGLDRVTFRRIIL--KNNA KKRKTYELFI--ES-VPLL-KSLEASERMKIVDVIGEKVYQDGERIISQGDKADCFYIVE SGEVKIMIKSKTMMSKE-ANQEVEIARCHRGQYF-G-E-LALVTNKPRAASAYAVGE--V KCLVMDVQAFERLLGPCMDIM--------KRNITHY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVAMF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSSM------------------------------- ---------------------------------------------------DLMDPGN >T_nigroviridis_ENSTNIP00000019115 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IEIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EGLTELLQSFTVEVLRNQPR-DLL--------------QFALQYFTQ-- -------LKE----AESKEAPFGNDQ-------------------NSAPRSGKAVNFIDE ---AMQ-----------------IDSENGE--DPNISPSE------PWWKRGANS----- --------------------APVINR-FSRR-AS--VCAEAFNPDED-EEE----KEPL- ------------------------------VTHPKTDEQRQRLQEACRDILLFKNL-DPE E-MSQVLDAMFEKFCT----EGEHIIDQD--DDGDNFY--VI-E--SGTFSIFV-KT--D STEKLVGCYDNRGSFGELALMYNTPRAATI--IATST-GALWCLDRLTFRRIIV--KNNA KKRKMYESFI--ET-LPLL-TSLELSERMKVVDVISSKVFSDSQQIIVQGDLADCFYIVE SGQVRITIKRGRTKKDP-EEEEVDIATLSRGQYF-G-E-LALVTNKPRAASAYAVGS--V KCLVMDVKAFERLLGPCMDIM--------KRNIANY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVTLF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSST------------------------------- ---------------------------------------------------AIEQRSQ >G_gallus_ENSGALP00000013072 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EAYNPDEE-EDD----AETR- ------------------------------IIHPKTDDQRNRLQEACKDILLFKNL-DPE Q-MSQVLDAMFEKLVE----GGEHVIDQG--DDGDNFY--VI-D--RGTYDIYV-KC--D GVGRCVGTYDNRGSFGELALMYNTPRAATI--IATSP-GAIWGLDRVTFRRIIV--KNNA KKRRMYENFI--ES-LPFL-KSLEVSERLKVVDVIGTKVYKDGEQIIAQGDMADSFFIVE SGEVRIIMTK--------ENGAVEIARCSRGQYF-G-E-LALVTNKPRAASAFALGT--V KCLVMDVQAFERLLGPCMEIL--------KRNIANY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVALF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GTNM------------------------------- ---------------------------------------------------DIADTS- >B_taurus_ENSBTAP00000018886 MSH--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IQIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PGLTELLQGYTVEVLRQRPP-DLV--------------DFAVDYFTR-- -------LRE----ARSRASTPPAAPPS-----------------GSQDFDPGAGLVADA --------------------------------VADSESE----------DEEDLD----- --------------------VPIPGR-FDRR-VS--VCAETYNPDEE-EED----TDPR- ------------------------------VIHPKTDQQRCRLQEACKDILLFKNL-DPE Q-LSQVLDAMFERTVK----VDEHVIDQG--DDGDNFY--VI-E--RGTYDILV-TK--D NQTRSVGQYDNHGSFGELALMYNTPRAATI--VATSE-GSLWGLDRVTFRRIIV--KNNA KKRKMFESFI--ES-VPLL-KSLEVSERMKIVDVIGEKVYKDGERIITQGEKADSFYIIE SGEVSILIKSKTKVNKDGENQEVEIARCHKGQYF-G-E-LALVTNKPRAASAYAVGD--V KCLVMDVQAFERLLGPCMDIM--------KRNISHY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVKMF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSSM------------------------------- ---------------------------------------------------DLIDPGQ >M_musculus_ENSMUSP00000035220 MSH--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IQIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------AGLTELLQGYTVEVLRQQPP-DLV--------------DFAVEYFTR-- -------LRE----ARRQESDTFIVSPT-----------------TFHTQESSAVPVIEE --------------------------------DGESDSDS---------EDADLE----- --------------------VPVPSK-FTRR-VS--VCAETFNPDEE-EED----NDPR- ------------------------------VVHPKTDEQRCRLQEACKDILLFKNL-DQE Q-LSQVLDAMFEKIVK----TDEHVIDQG--DDGDNFY--VI-E--RGTYDILV-TK--D NQTRSVGQYDNRGSFGELALMYNTPRAATI--IATSE-GSLWGLDRVTFRRIIV--KNNA KKRKMFESFI--ES-VPLF-KSLEMSERMKIVDVIGEKIYKDGERIIAQGEKADSFYIIE SGEVSILIRSKTKSNKNGGNQEVEIAHCHKGQYF-G-E-LALVTNKPRAASAYAVGD--V KCLVMDVQAFERLLGPCMDIM--------KRNISHY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVKMF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSNL------------------------------- ---------------------------------------------------DLMDPGQ >T_rubripes_ENSTRUP00000023587 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IEIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------VGLTELLQGFTVEVLRQRPS-DLV--------------DFAVQYFTR-- -------LRD----TKSQDGS------------------------GAAGKTGKGVMFDGE ---PMQ-----------------TESNG----EDDED------------DDSDFELLKSL HRPRNDEKKHKKLPCSYTFRAPPPSR-FNRR-VS--VCAEAFNPDED-DED----SEPR- ------------------------------VVHPKTDVQRCRLQEACRDILLFKTL-DQE Q-FSQVLDAMFESRVQ----AQEHVIDQG--DDGDNFY--VI-E--RGVFDIVV-S---- --GNCVGQYNNKGSFGELALMYNTPRAATI--IATQE-GALWGLDRATFRRLIV--KNNA KKRRMYETFI--ES-VPLL-KSLEVTERMKLVDVLGAKQFSDSERIITQGDKADCFYIVE SGEVKIMMKSKTKAGHA-DNAEVEITRCSRGQYF-G-E-LALVTNKPRAASAYAVGD--V KCLVVDVQAFERLLGSCKEIM--------KRNIAHY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVALF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSSM------------------------------- ---------------------------------------------------DLRD--- >H_sapiens_ENSP00000265563 MSH--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IQIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PGLTELLQGYTVEVLRQQPP-DLV--------------EFAVEYFTR-- -------LRE----ARAPASVLPAATPRQSL--------------GHPPPEPGPDRVADA --------------------------------KGDSESE----------EDEDLE----- --------------------VPVPSR-FNRR-VS--VCAETYNPDEE-EED----TDPR- ------------------------------VIHPKTDEQRCRLQEACKDILLFKNL-DQE Q-LSQVLDAMFERIVK----ADEHVIDQG--DDGDNFY--VI-E--RGTYDILV-TK--D NQTRSVGQYDNRGSFGELALMYNTPRAATI--VATSE-GSLWGLDRVTFRRIIV--KNNA KKRKMFESFI--ES-VPLL-KSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIE SGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYF-G-E-LALVTNKPRAASAYAVGD--V KCLVMDVQAFERLLGPCMDIM--------KRNISHY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVKMF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSSV------------------------------- ---------------------------------------------------DLGNLGQ >C_familiaris_ENSCAFP00000017836 MSH--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IQIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PGLTELLQGYTVEVLRQQPP-DLV--------------DFAVDYFTR-- -------LRE----ARLQASSPPAAPPS-----------------GSQGLEPSPGLVADA --------------------------------KADSESE----------DDEDLD----- --------------------VPIPSR-FDRR-VSDLVCAETYNPDEE-EED----TDPR- ------------------------------VIHPKTDQQRCRLQEACKDILLFKNL-DQE Q-LSQVLDAMFERTVK----VDEHVIDQG--DDGDNFY--VI-E--RGTYDILV-TK--D NQTRSVGQYDNRGSFGELALMYNTPRAATI--IATSE-GSLWGLDRVTFRRIIV--KNNA KKRRMFESFI--ES-VPLL-KSLEMSERMKIVDVIGEKAYKDGERIITQGEKADSFYIIE SGEVSILIRSKTKANKDGGNQEVEIARCHKGQYF-G-E-LALVTNKPRAASAYAVGD--V KCLVMDVQAFERLLGPCMDIM--------KRNISHY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVKMF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSSM------------------------------- ---------------------------------------------------DLIDPGQ >M_domestica_ENSMODP00000016745 H----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IEIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PGLTELLQGYTVEVLRNHPE-DLV--------------DFAVDYFTR-- -------LRE----NRRLGEDGEKDEGRGDEEDEHA---------GPSSHPDLPFPLHSS --------------------------------EPGKPASL---------CQFFLS----- --------------------APVINR-YNRR-VS--VCAESFNPDE--EDD----TEPK- ------------------------------VIHPKSDEQRSRLQEACKDILLFKNL-DQE Q-LSEVLDAMFERIVV----SEEHVIDQG--DDGDNFY--VI-E--RGKYDILV-TK--E NQSFRVGQYDNRGSFGELALMYNTPRAATI--VAITE-GSLWGLDRITFRRIIL--KNNA KKRKMFESFI--ES-VPLL-KSLEVSERMKIVDVIGEKNYKDGEQIIAQGDKAESFYIVE SGEVKILIKSKTNKD---TEDEVEIARCQKGQYF-G-E-LALVTNKPRAASAYAVGD--V KCLVMDVQAFERLLGPCMDIM--------KRNISNY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVKMF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSSV------------------------------- ---------------------------------------------------DLSDPGN >R_norvegicus_ENSRNOP00000027552 MSH--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IQIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PGLTELLQGYTVEVLRQQPP-DLV--------------DFAVEYFTR-- -------LRE----ARRQESDSFIAPPT-----------------TFHAQESSGVPVIEE --------------------------------DGESESDS---------DDEDLE----- --------------------VPIPSK-FTRR-VS--VCAETFNPD-E-EED----NDPR- ------------------------------VVHPKTDEQRCRLQEACKDILLFKNL-DQE Q-LSQVLDAMFEKIVK----TDEHVIDQG--DDGDNFY--VI-E--RGTYDILV-TK--D NQTRSVGQYDNRGSFGELALMYNTPRAATI--VATSD-GSLWGLDRVTFRRIIV--KNNA KKRKMFESFI--ES-VPLF-KSLEMSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIE SGEVSILIRSKTKTNKNGGNQEVEIAHCHKGQYF-G-E-LALVTNKPRAASAYAVGD--V KCLVMDVQAFERLLGPCMDIM--------KRNISHY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVKMF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSNL------------------------------- ---------------------------------------------------DLLDPGQ >M_mulatta_ENSMMUP00000000105 MSH--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IQIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PGLTELLQGYTVEVLRQQPP-DLV--------------EFAVDYFTR-- -------LRE----ARAPASVLPAATPRQSP--------------GHPPPEPGPDRVADA --------------------------------KGDSESE----------EDEDLE----- --------------------GAIPSR-FVLK-CS--VCAETYNPDEE-EED----TDPR- ------------------------------VIHPKTDEQRCRLQEACKDILLFKNL-DQE Q-LSQVLDAMFERIVK----ADEHVIDQG--DDGDNFY--VI-E--RGTYDILV-TK--D NQTRSVGQYDNRGSFGELALMYNTPRAATI--VATSE-GSLWGLDRVTFRRIIV--KNNA KKRKMFESFI--ES-VPLL-KSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIE SGEVSILIRSKTKSNKDGGNQEVEIARCH-GQYF-G-E-LALVTNNPRAASAYAVGD--V KCLVMDVQAFERLLGPCMDIM--------KRNISHY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVKMF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSSM------------------------------- ---------------------------------------------------DLGNLGQ >P_troglodytes_ENSPTRP00000025724 MSH--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IQIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PGLTELLQGYTVEVLRQQPP-DLV--------------EFAVEYFTR-- -------LRE----ARAPASVLPAATPRQSL--------------GHPPPEPGPDRVADT --------------------------------KGDSESE----------EDEDLE----- --------------------VPVPSR-FNRR-VS--VCAETYNPDEE-EED----TDPR- ------------------------------VIHPKTDEQRCRLQEACKDILLFKNL-DQE Q-LSQVLDAMFERIVK----ADEHVIDQG--DDGDNFY--VI-E--RGTYDILV-TK--D DQTRSVGQYDNRGSFGELALMYNTPRAATI--VATSE-GSLWGLDRVTFRRIIV--KNNA KKRKMFESFI--ES-VPLL-KSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIE SGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYF-G-E-LALVTNKPRAASAYAVGD--V KCL--------RLLGPCMDIM--------KRNISHY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVKMF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSSV------------------------------- ---------------------------------------------------DLGNLGQ >O_latipes_ENSORLP00000003826 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IEIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------VGLTELLQGYTVEVLRQRPS-DLV--------------EFAVQYFTR-- -------LRD----SRARQNAILISSPQRFHIKE-----------STGGRISIEWDLNSK ---QKY-------------------------------------------ETKNQN----- --------------------APPPSR-FNRR-VS--VCAEAFNPDDD-DED----TEPR- ------------------------------VVHPKTDEQRCRLQEACRDILLFKTL-DQE Q-FSQVLDAMFELKVQ----PQEHVIDQG--HDGDNFY--VI-E--RGIYDIVV-S---- --GKCVGQYNNKGSFGELALMYNTPRAATI--IATQE-GALWGLDRATFRRLIV--KNNA KKRRMYETFI--ES-VPLL-KTLEPNERMKIVDVLGMKQFLDGERIIAQGEKAECFYIVE SGEVKIMMKSKTKADHA-DNAEVEITRCSRGQYF-G-E-LALVTNKPRAASAYAVGD--V KCLVIDVQAFERLLGSCKEIM--------KRNISHY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVALF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSSM------------------------------- ---------------------------------------------------DLRD--- >G_aculeatus_ENSGACP00000007645 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IEIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------VGLTELLQGYTVEVLRQRPS-DLV--------------DFAVQYFSR-- -------LRD----TRSQDGD------------------------TAGGKTAKDSDFERG ---AFL-----------------TVKNCSADGEVRD-------------GPQVDR----- --------------------APPPSR-FSRR-VS--VCAEAFNPDDD-DED----TEPR- ------------------------------VVHPKTDEQRCRLQEACRDILLFKTL-DQE Q-FSEVLDAMFELRVQ----PLEHVIDQG--DDGDNFY--VI-E--RGVYDIMV------ -MGTTVGQYNNKGSFGELALMYNTPRAATI--AATEE-GALWGLDRATFRRLIV--KNNA KKRRVYEAFI--ES-VPLL-KSLEANERMKIVDVLGSKQFPDGERIITQGDKAECFYIVE SGEVKIMMKSKTKADHA-DNAEVEITRCSRGHYF-G-E-LALVTNKPRAASAYAVGD--V KCVVIDIQAFERLLGSCKEIM--------KRNIAHY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVALF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSSM------------------------------- ---------------------------------------------------DLRD--- >P_pygmaeus_ENSPPYP00000015541 MSH--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IQIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PGLTELLQGYTVEVLRQQPP-DLV--------------EFAVDYFTR-- -------LRE----ARAPASVLPAATPRQSL--------------RHSTLEPGPDRVADA --------------------------------KGDSESE----------EDEDLE----- --------------------VPVPSR-FNRR-VS--VCAETYNPDEE-EED----TDPR- ------------------------------VIHPKTDEQRCRLQEACKDILLFKNL-DQE Q-LSQVLDAMFERIVK----ADEHVIDQG--DDGDNFY--VI-E--RGTYDILV-TK--D NQTRSVGQYDNRGSFGELALMYNTPRAATI--VATSE-GSLWGLDRVTFRRIIV--KNNA KKRKMFESFI--ES-VPLL-KSLEVSERMKIVDVIGEKIYKDGERIITQ----------- -----------TKSNKDGGNQEVEIARCHKGQYF-G-E-LALVTNKPRAASAYAVGD--V KCLVMDVQAFERLLGPCMDIM--------KRNISHY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVKMF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSSV------------------------------- ---------------------------------------------------DLGNLGQ >D_rerio_ENSDARP00000046625 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------NDDD---------DDNNYY----- --------------------APVINR-FVRR-AS--VCAEAYNPDED-EEE----REPR- ------------------------------VTYPKTDEQRQRLQEACKDILLFKNL-DQE Q-MSQVLDAMFEKVVV----SGEHIIDQD--DDGDNFY--VI-E--RGMFEILL-KA--D GTTRTVGSYDNRGSFGELALMYNTPRAATI--IATSP-GALWCLDRLTFRRIIV--KNNA KKRKMYEAFI--GT-LPLL-TSLEVSERMKVVDVLSTKVYNGGEQIIAQGDLADCFYIVE SGHVRITMKRSKSKNDT-EDEEVEIATCSRGQYF-G-E-LALVTNKPRAASAYAMDS--V KCLVMDVQAFERLLGPCMDIM--------KRNIANY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLITLF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSQI------------------------------- ---------------------------------------------------AIEEPNA >O_latipes_ENSORLP00000023083 MSK--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------FEIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------AGLKELLQGYTVEVLRRRPA-NLA--------------QFAVQHFTQ-- -------VLE----SQRNEQAAESHST------------------GPAEEEEDDDAFETA --------------------------SNPSISDEDEE------------EERNIV----- --------------------KAKADR-CSRR-VA--VCAETYNPDEDEDND----TEPQ- ------------------------------VVHPKTDEQRQRLQDACKDILLFKTL-AKE Q-FSEVLDAMFEVLVK----PEEHIIDQG--DDGDNFY--VI-E--KGVFDIYV-QK--D GLNVCVGKYNNKGSFGELALMYNTPRAATI--VAKQD-GALWALDRATFHRLIV--KNNA KKRRMYEAFI--EC-VPLL-KSLELSERMKIVDVLGVRTFSDGERIITQGDKADCFFIVE SGEVKIMIKSK-KAGQP-DGVEVEVARCSRGQYF-G-E-LALVTNKPRAATAYAVGD--T KCLVIDIQAFERLLGPCMDIM--------KRNISQY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------KDQLMALF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------G---------------------------------- ---------------------------------------------------------- >D_rerio_ENSDARP00000048675 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------DLF--------------L---------- ------------------------------------------------------------ -------------------------------------------------SVFLST----- --------------------APPPSR-FNRR-VS--VCAEAFNPDDD-EED----SEPR- ------------------------------VVHPKTDEQRCRLQEACKDILLFKAL-DQE Q-FSEVLDAMFEVLVQ----PQDHVIDQG--DDGDNFY--VI-E--RGVYDIVV-QK--D GVGCCVGQYNNKGSFGELALMYNTPRAATI--IAKDE-GALWGLDRATFRRLIV--KNNA KKRRMYECFI--ES-IPLL-KSLELSERMKIVDVLGVKTFQDGERIIMQGDKADCFYIVE SGEVKIMMKSKTKADRQ-DNAEVEIARCSRGQYF-G-E-LALVTNKPRAASAYAIGD--V KCLVIDIQAFERLLGPCKEIM--------KRNIAHY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVALF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSSV------------------------------- ---------------------------------------------------DLRD--- >G_aculeatus_ENSGACP00000001531 MSS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------VEIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------AGLKELLQGYTVEVLRREPP-DLV--------------EFAVQHFTR-- -------ILE----GQKKNRGAKKRSTR---------------------PARKGVTFDTV SNKPSK-----------------VDDD-----EEEEDTISDKNHTKDKEKLSSQK----- --------------------QSTTSK-YNRR-VS--VCAEAYNPDDDEDDD----AELR- ------------------------------IVYPKTDVQRRRLQDACRDILLFKTL-EQE Q-FSEVLDGMFEVLVK----PQEHIIDQG--ADGDNFY--VI-E--KGVYDILV-QK--G GVSVCVGKYDNKGSFGELALMYNTPRAATI--IATQE-GALWGLDRATFHRLIV--RNNA KKRRTYEAFI--EC-VPLL-KSLELSERMKIVDVVGARVFKDGERLITQGEEADCFYVVE SGEVKIMITSQAKAG---QQDEVEVARCSRGQYF-G-E-LALVTNKPRAASVYAVGE--T KCLVIDIQAFERLLGPCMDIM--------KRNISQY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQRVALM------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSSV------------------------------- ---------------------------------------------------D------ >A_carolinensis_ENSACAP00000011863 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------VCAEAYNPDEE-DED----TEPR- ------------------------------VVHPKTDEQRCRLQEACKDILLFKNL-DQE Q-LSQVLDAMFERKVQ----PQEHVIDQG--DDGDNFY--VI-E--RGLYDIFV-AR--D GQTRCVGRYDNHGSFGELALMYNTPRAATI--VATTE-GALWGLDRVTFRRIIL--KNNA KKRKTYELFV--ES-VPLL-KSLEPSERMKIVDVIGEKVFQDGERIICQGDKADSFYIVE CGEVKILIKSKTITGKD-ANQEIEIARCQKGQYF-G-E-LALVTNKPRAASAYAVGE--V KCLVMDVQAFERLLGPCMDIM--------KRNITHY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVALF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSSM------------------------------- ---------------------------------------------------DLTNPGN >T_rubripes_ENSTRUP00000043508 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------APVINR-FCRR-AS--VCAEAFNPDED-EEE----KEPL- ------------------------------VTYPKTDEQRQRLQEACRDILLFKNL-DPE E-MSQVLDAMFEKFCT----EGEHIIDQD--DEGNNFY--VI-E--SGTFSIFV-KT--D STEKLVGCYDNRGSFGELALMYNTPRAATI--IATSP-GALWCLDRLTFRRIIV--KNNA KKRKMYESFI--ET-LPLL-TSLELSERMKVVDVISSKVFNDSQQIIAQGDLADCFYIVE SGQVRITIKRSRTKKDP-EEEEVDIAALSRGQYF-G-E-LALVTNKPRAASAYAVGS--V KCLVMDVKAFERLLGPCMDIM--------KRNIANY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVTLF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSST------------------------------- ---------------------------------------------------EI----- >T_nigroviridis_ENSTNIP00000014986 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IEIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------VGLTELLQGFTVEVLRQRPS-DLV--------------DFAVHYFTR-- -------LRD----TKSQDGA------------------------GAGGKMGKGVMFDGE ---PMQ-----------------TESNG----EDDED------------DDSDFE----- --------------------PPPPSR-FNRR-VS--VCAEAFNPDED-DED----SEPR- ------------------------------VVHPKTDEQRCRLQEACRDILLFKTL-DQE Q-FSQVLDAMFESRVQ----PQEHVIDQG--DDGDNFY--VI-E--RGVFDIVV-S---- --GNCVGQYNNKGSFGELALMYNTPRAATI--VATQE-GALWGLDRATFRRLIV--KNNA KKRRMYETFI--ES-VPLL-KSLEATERMKLVDVLGAKQFSDSERIITQ----------- -----------TKADHA-DNAEVEIARCSRGQYF-G-E-LALVTNKPRAA-AYAVGD--V KCLVIDVQAFERLLGSCKEII--------KRNIAHY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVALF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSSM------------------------------- ---------------------------------------------------DL----- >D_rerio_ENSDARP00000006288 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------VPVP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------AGLPELLRGFTLEVLRRQPA-DLL--------------EFSVRYFTG-- -------LRD----TRSSTRSASSRS-----------------------PVTRGEAFDRD ---SAH--TDSSVEEEEKPEEEEEEEEKPEEEDEEEDDFP---------DDFTFK----- --------------------APPPSK-CNRR-VS--VCAEPYNPDED-DDDGDEGSQLT- ------------------------------VLHQKTDEQRQRLQDACKHILLFKTL-EED Q-LAEVLDSMFEVLVK----PGECIINQG--DDGDNFY--VI-E--RGVYEIVI-QQ--D GLQHSVGRYDHKGSFGELALMYNTPRAATI--RALQE-GALWALDRATFHRLIV--KNNA KKRRMYESFI--EC-VPLL-KSLQLSERMKIVDVLGMRSFSDGERIIQQGDSADCFYIVE SGEVRIMIRSKTRACQL-LQEEVEVARCSRGQYF-G-E-LALVTKRPRAASVYAVGD--T RCLVIDVQAFERLLGSCKQIL--------KRNITHY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EQQLVAVF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSSV------------------------------- ---------------------------------------------------DLKH--- >G_gorilla_ENSGGOP00000008988 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------PVPSR-FNRR-VS--VCAETYNPDEE-EED----TDPR- ------------------------------XXXXXXXXXXXXXXXXXXXXXXXXXX-XQE Q-LSQVLDAMFERIVK----ADEHVIDQG--DDGDNFY--VI-E--RGTYDILV-TK--D NQTRSVGQYDNRGSFGELALMYNTPRAATI--VATSE-GSLWGLDRVTFRRIIV--KNNA KKRKMFESFI--ES-VPLL-KSLEVSEXMKIVDVIGEKIYKDGERIITQXXXADSFYIIE SGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYF-G-E-LALVTNKPRAASAYAVGD--V TCLVMDVQAFERLLGPCMDIM--------KRNISHY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVKMF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSSV------------------------------- ---------------------------------------------------DLGNLGQ >E_caballus_ENSECAP00000017462 MAD--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------QVKPISPLKNLLAGGFGGMCLVFVGHPLDTVKVR LQTQPPSLPGQPPMYSGTFDCFRKTLIREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGK KLQQKCPEDVLSYPQLFAAGMLSGVFTTGIMTPGERIKCLL-QIQASSGDTKYTGPL--- --DCAKKVYQESGIRGIYKGTVLTLMRDVPA-SGM--------------YFMT--YEW-- -------LKN----IFTPEGKSVNELSVPRILVAGGIAG-IFNWAVAIPPDVLKSRFQTA ---PPG---------------------------------KYPNGFKDVLRELIRD----- --------------------EGVTSL-YKGF-NA--VMIRAFPANAV-TPP----KVPY- ------------------------------SDF-------------------------PE Q-LSQVLDAMFERTVK----VDEHVIDQG--DDGDNFY--VI-E--RGTYDILV-TK--D NQTRSVGQYDNHGSFGELALMYNTPRAATI--VATSE-GSLWGLDRVTFRRIIV--KNNA KKRKMFESFI--ES-VPLL-KSLEVSERMKIVDVIGEKSYKDGERIITQGEKADSFYIIE SGEVSILIKSKTKANKDGGNQEVEIARCHKGQYF-G-E-LALVTNKPRAASAYAVGD--V KCLVMDVQAFERLLGPCMDIM--------KRNISHY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVKMF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSSL------------------------------- ---------------------------------------------------DLIDPGQ >T_nigroviridis_ENSTNIP00000017695 MSK--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------QQKPISPLKNFFAGGFGGVCLVFAGHPLDTIKVR LQTQPKAKPGETLLYRGTFDCFKKTLAKEGVRGLYKGMAAPIIGVTPMFAVCFFGFGLGK KLQQKSPDDVLTYPQLFAAGMLSGVFTTAIMTPGERIKCLLQQIQASTGKVKFNGPI--- --DCVKQLYRESGIRGIYKGTALTLMRDVPA-SGM--------------YFMS--YEW-- -------LKN----DLTPPGKSHNELSVPSILFAGGMAG-IFNWAVAIPPDVLKSRFQTA ---PEG---------------------------------KYPNGFRDVLRELVRE----- --------------------EGVASL-YKGF-NA--VMLRAFPANAS-PPP----ANPT- ------------------------------AEF-------------------------PE Q-FSEILDAMFEVLVK----PQQHIIDQG--DDGDNFY--VI-E--KGTFDIFV-QK--D GASLCVGKYDNKGSFGELALMYNTPRAATI--VATQE-GALWALDRATFHRLIV--KNNA KKRRMYEAFI--ES-VPLL-KSLELSERMKIVDVLAARSFKDEERIITQGDEADCFYIVE SGQVKIKIKSKTKVSEQ-NNGEVEVARCVRGQYF-G-E-LALVTNKPRAASVYAVGE--T KCLVIDIQAFERLLGPCMDIM--------KRNISLY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EDQLVALF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSSE------------------------------- ---------------------------------------------------DL----- >T_rubripes_ENSTRUP00000028483 MSK--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------QQKPISPLKNFFAGGFGGVCLVFAGHPLDTIKVR LQTQPKPKPGETLLYKGTFDCFKKTLAKEGLKGLYKGMAAPIIGVTPMFAVCFFGFGLGK KLQQKSPDDILTYPQLFAAGMLSGVFTTAIMTPGERIKCLL-QIQASTGNVKYNGPM--- --DCVKQLYRESGIRGIYKGTALTLMRDVPA-SGM--------------YFMT--YEW-- -------LKT----LLTPPGKSHNELSIPSILFAGGMAG-IFNWAVAIPPDVLKSRFQTA ---PEG---------------------------------KYPNGFRDVLRELIRE----- --------------------EGVASL-YKGF-NA--VMLRAFPANAA-APV----TQRC- ------------------------------CSL-------------------------QE Q-FSEILDAMFEVLVK----PQQHIIDQG--DDGDNFY--VI-E--TGTFDIFV-KK--D GANLCVGKYDNKGSFGELALMYNTPRAATI--VATQD-GALWALDRATFHRLIV--KNNA KKRRMYEAFI--ES-VALL-KSLELSERMKIVDALAARGFKDGERIITQGDDADCFYIVE SGQVRIMIKSKTKVSEQ-NNVEVEVARCSRGHYF-G-E-LALVTNKPRAASVYAVGE--T KCLVIDIQAFERLLGPCMDIM--------KRNISLY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EDQLVALF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSSD------------------------------- ---------------------------------------------------DL----- >A_gambiae_AGAP004940-PA MSS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------QQKHRIQVP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------DGLRDVLLEFSIAYLLEQPG-DVI--------------DYAVTFFTK-- -------LQE----DRKTTMIT-------------------------------------- -----------------------SAEPTSPDESIMSHDEGRY------------------ --------------------KPLVNRYASRR-KS--VFAETYDPEND-DED----EGAR- ------------------------------AIFPKTDEQRARLCDSVKNILLFRSL-DKE Q-MNEVLDAMFEKIVQ----AKDYIIKQG--DDGDNFY--VI-E--SGIYNAYV-GE--- -DQKHIHTYDNRGSFGELALLYNMPRAATI--QAETD-GKLWAMDRQTFRRILL--KSAF RKRKMYEALL--DA-VPML-KTLQNYERMNLADALIPQTYAKGDRIIKQGDAADGMYFIE DGKVSIRIQQ--------DAGEVEISNLEKGGYF-G-E-LALVTHRPRAASAYAVDN--V KVAFLDVDAFERLLGPCMNIM--------KRNIGDY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ETQLVKIF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSKN------------------------------- ---------------------------------------------------NITD-IR >D_melanogaster_FBpp0087524 MSS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSSRRIQVP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EELKEVLLQFSISFLVEQPP-DVI--------------DYAVEYFTK-- -------LQS----ERPSVSH--------------------------------------- -----------------------TDQSTDDQLSVNSQDADA------------------- --------------------EPPVMA-SSRR-KS--VFAEAYDPEAD-DDD----DGAT- ------------------------------AVFPKTDEQRARLVESVKNVLLFRSL-EKE Q-MNQVLDAMFERKVQ----PGDFIIRQG--DDGDNFY--VI-E--SGVYKVYI-ND--- ---KHINTYNHTGLFGELALLYNMPRAATV--QAETS-GLLWAMDRQTFRRILL--KSAF RKRKMYEELL--NS-VPML-KALQNYERMNLADALVSKSYDNGERIIKQGDAADGMYFIE EGTVSVRMDQ--------DDAEVEISQLGKGQYF-G-E-LALVTHRPRAASVYATGG-VV KLAFLDVKAFERLLGPCMDIM--------KRNIDDY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ESQLVKIF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSKN------------------------------- ---------------------------------------------------NITD-TR >O_cuniculus_ENSOCUP00000010696 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------CAEAYNPDEE-EED----TDPR- ------------------------------VIHPKTDEQRCRLQESCKDILLFKNL-DQE Q-LSQVLDAMFERIVK----VDEHVIDQG--DDGDNFY--VI-E--XXXXXXXX-XX--X XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXX-XXXXXXDRVTFRRIIV--KNNA KKRKMFESFI--ES-VPLL-KSLEXXXXXXXXXXXXXXXXXXXXXXXXXGEKADSFYIIE SGEVSILIKSKTKSNKDGGNQEVEIARCHKGQYF-G-E-LALVTNKPRAASAYAVGD--V KCLVMDVQAFERLLGPCMDIM--------KRNISHY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVKIF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSSM------------------------------- ---------------------------------------------------DLIDPGQ >C_intestinalis_ENSCINP00000014963 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GSATNQDDEEMVASDNDDYMDE-------AEEMAM----- --------------------MARRTN-VSRR-KS--VSAEGFDPDAD-DDD----DEEK- ------------------------------VIHPKTDEQRDRLSKVISKMLIFSSL-DIE Q-TQQVLDAMFEKSVK----AGDHVIDEG--DDGDNFY--VI-E--KGDFDIFI-NDPVT KVPDHKGTYKGSGAFGELALMYNCPRLATI--IATTD-GSLWGMDRTTFRRIIV--KNAA KKRKQYEDFL--AT-VPLL-STLTVEERMKVADAMVTKNYEDEDCILKQGDPADYFYIVI DGQVVVKRRGDDPSN---ANHEVVLKKYTNGEYF-G-E-LALIQNQPRAASAFAEGP--C KCAVLDVQAFERLLGPCKELL--------MRNIPLY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EQQLSEIY------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------QDM------------------------------- ---------------------------------------------------SMSE--- >M_domestica_ENSMODP00000000553 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------GGSTRAGVPSEGLSFQEERKEGGAPDGGGKEEADPA-------GAGVAG----- --------------------AVVRGR-YQRR-SS--IPAEAFGPSEGEEELMEETTVVW- ------------------------------AIYPKSEEQVRKLKEACKDLLPFRGL-EDE L-LLQIFSAMFEKKVL----PQEHVVEQG--EDGDHFY--VI-E--DGIFDVIV-QN--N SQHNIIGQYKHMGAFGELALMYSYPRPATI--VAITE-GSLWGLDRPTFRTITV--TFQL EKKKKIQMLL--SN-VPFF-KSLEDTESVKILDVVEENNYQSGECIFPKGQTSDKFYIVE SGEVKIVGEKL-------GSKEAEIVRHHEEDFF-G-E-SALISNKPRTTSAYAVGK--V KCIVMDVQALERVLGPYMDIL--------KRDMSQY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EE-LIKLL------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GPQI------------------------------- ------------------------------------------------------DTKA >O_anatinus_ENSOANP00000014875 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------DNGEED-----------REITPP----- --------------------SPSWRR-YQRR-AS--VQAEAINPGEG-SSVSSPAGVRW- ------------------------------AQHPKSAEQMKRLKETCETLLPFREL-EEE L-LTQIFSAMFERKVE----AQEHVVEQG--EDGDYFYAIAI-E--SGMYDLLV-AR--N KQDCRIGRYEDRGAFGELALMYSYPRPATI--VALTA-GVLWGLDRKTFRTITV--TFQA ERRKKFESLI--NS-VPFF-RSLEKSEKMKLLDMIESKTYRHGDCIFAQGEMADKFYIVE SGEVKMLTEMP-------TGKEVGIVKLNPGEYF-G-E-GALVGNKPRTSSAYAVGD--A KCIVMNVEALERLLGPCLDIL--------KRDMAQF------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------KD-LIALH------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DSSV------------------------------- ---------------------------------------------------DLSEEHK >A_aegypti_AAEL009216-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------EPLVNRYASRR-KS--VFAETYDPEAD-DDD----DGAR- ------------------------------AIFPKTDEQRARLCDSVKNILLFR-L-MNT I-MNEVLDAMFEKKVK----AKDYIIKQG--DDGDNFY--VI-E--SGIYKAYV-GE--- -DQKHIHTYDNSGSFGELALLYNMPRAATI--QAETD-GQLWAMDRQTFRRILL--KSAF RKRKMYEALL--DA-VPML-KTLQSYERMNLADALIPKTFAKGERIIKQGDAADGMYFIE EGKVSIRIQQ--------DAGEVEISNLEKGQYF-G-E-LALVTHRPRAASAYAVDN--V KVAFLQTDCFERLLGKVLDVM--------LRGMKHY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RYVDQSVW------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------KMILEACRE------------------------------- ---------------------------------------------------ENSQ-VR >H_sapiens_ENSP00000385749 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MASPPACPSEEDESL--- --KGCELYVQLHGIQQVLKDCIVHLCISKPE-RPM--------------KFLREHFEK-- -------LEK----EENRQILA-------------------------------------- -----------------------RQKSN-SQSDSHDEEV----------SP-TPP----- --------------------NPVVKA-RRRR-GG--VSAEVYTEE---DAV----SYVR- ------------------------------KVIPKDYKTMTALAKAISKNVLFAHL-DDN E-RSDIFDAMFPVTHI----AGETVIQQG--NEGDNFY--VV-D--QGEVDVYV-NG--- ---EWVTNISEGGSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIIT EGTASVLQRRSP------NEEYVEVGRLGPSDYF-G-E-IALLLNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSEIL--------KRNIQRY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFISLTV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >M_musculus_ENSMUSP00000026973 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MASPSCFHSEDEDSL--- --KGCEMYVQKHGIQQVLKECIVHLCVAKPD-RPL--------------RFLREHFEK-- -------LEK----EENRQILA-------------------------------------- -----------------------RQKSN-SQCDSHDEEI----------SP-TPP----- --------------------NPVVKA-RRRR-GG--VSAEVYTEE---DAV----SYVR- ------------------------------KVIPKDYKTMTALAKAISKNVLFSHL-DDN E-RSDIFDAMFPVTHI----GGETVIQQG--NEGDNFY--VI-D--QGEVDVYV-NG--- ---EWVTNISEGGSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIIT EGTASVLQRRSP------NEEYVEVGRLGPSDYF-G-E-IALLLNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSEIL--------KRNIQRY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFISLTV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >M_domestica_ENSMODP00000010661 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MASSSSYNLEEDESL--- --KGCELYVQKHNIQQLLKECIVNLCISKPD-RPM--------------KFLREHFEK-- -------LEK----EECKQILA-------------------------------------- -----------------------RQKLS-SQSDSHDDEI----------SP-PPP----- --------------------NPVVKA-RCRR-GG--VSAEVYTEE---DAV----SYVR- ------------------------------KVIPKDYKTMTALAKAISKNVLFAHL-DDN E-RSDIFDAMFPVTHI----AGETVILQG--DEGDNFY--VI-D--QGEVDVYV-NM--- ---EWVTNIGEGGSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLDKWERLTVADALETAQFEDGEKIVVQGQPGDDFFIIT EGTASVLQRRSD------NEEYVEVGRLGPSDYF-G-E-IALLLNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSEIL--------KRNIQRY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFISLTV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >R_norvegicus_ENSRNOP00000033202 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MSPQIM------------ ---------------------CVSVCGEGMGWDPV--------------EISQSHAEG-- -------CAQTTGLEENRQILA-------------------------------------- -----------------------RQKSN-SQCDSHDEEI----------SP-TPP----- --------------------NPVVKA-RRRR-GG--VSAEVYTEE---DAV----SYVR- ------------------------------KVIPKDYKTMTALAKAISKNVLFSHL-DDN E-RSDIFDAMFPVTHI----DGETVIQQG--NEGDNFY--VI-D--QGEVDVYV-NG--- ---EWVTNISEGGSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIIT EGTASVLQRRSP------NEEYVEVGRLGPSDYF-G-E-IALLLNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSEIL--------KRNIQRY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFISLTV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >C_familiaris_ENSCAFP00000016544 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TMASQSSYQVEEDESL--- --KECELYVQKHGVQQVLKDCIVHLCISKPD-RPM--------------TFLREHFEK-- -------LEK----EENRQIQS-------------------------------------- -----------------------QQK-----SDSHDEEV----------SP-TPP----- --------------------NPVVKA-RRRR-GG--VSAEVYTEE---DAV----SYVR- ------------------------------KVIPKDYKTMTALAKAISKNVLFAHL-DDN E-RSDIFDAMFPVTHI----AGETVIQQG--DEGDNFY--VI-D--QGEVDVYV-NG--- ---EWVTSISEGGSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFFIIT EGTASVLQRRSP------NEEYMEVGRLGPSDYF-G-E-IALLLNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSEIL--------KRNIQRY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFISLTV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >A_carolinensis_ENSACAP00000000612 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TMATSSSCNLEDDESL--- --KGCELYVQKHNIQQILKECIVNLCIAKPD-RPM--------------KFLREHFEK-- -------LEK----EECKQILA-------------------------------------- -----------------------CQKSN-SQSDSHDDEI----------SP-PPP----- --------------------NPAVKA-RHRR-GG--VSAEVYTEE---DAV----SYVR- ------------------------------KVIPKDYKTMTALAKAISKNVLFAHL-DDN E-RSDIFDAMFPVTHI----AGEIVIQQG--DEGDNFY--VI-D--QGEVDVYV-NG--- ---EWVTSIGEGGSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTL RKRKMYEKFL--SK-VSIL-ESLEKWERLTVADALEPVQFEDGEKIVVQGQPGDDFFIIT EGTASVLQRRSD------KEEYVEVGRLGPSDYF-G-E-IALLLNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSEIL--------KRNIQRY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFISLTV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >G_gallus_ENSGALP00000005814 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MAAASSCSVEEDESL--- --KGCELYVQKHNIQQILKECIVNLCIAKPD-RPM--------------KFLREHFEK-- -------LEK----EECKQILA-------------------------------------- -----------------------RQKSS-SQSDSHDDEI----------SP-PPP----- --------------------NPVVKA-RRRR-GG--VSAEVYTEE---DAV----SYVR- ------------------------------KVIPKDYKTMTALAKAISKNVLFAHL-DDN E-RSDIFDAMFPVTHI----AGETVIQQG--DEGDNFY--VI-D--QGEVDVYV-NG--- ---EWVTSIGEGGSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLDKWERLTVADALEPVQFEDGEKIVVQGEPGDDFFIIT EGTASVLQRRSD------NEEYVEVGRLGPSDYF-G-E-IALLLNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSEIL--------KRNIQRY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFISLTV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >T_guttata_ENSTGUP00000008775 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MAAAASCNVEEDESL--- --KGCELYVQKHNIQQILKECIVNLCIAKPD-RPM--------------KFLREHFEK-- -------LEK----EECKQILA-------------------------------------- -----------------------RQKSS-SQSDSHDDEI----------SP-PPP----- --------------------NPVVKA-RRRR-GG--VSAEVYTEE---DAV----SYVR- ------------------------------KVIPKDYKTMTALAKAISKNVLFAHL-DDN E-RSDIFDAMFPVTHI----AGETVIQQG--DEGDNFY--VI-D--QGEVDVYV-NG--- ---EWVTSIGEGGSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLDKWERLTVADALEPVQFEDGEKIVVQGEPGDDFFIIT EGTASVLQRRSD------NEEYVEVGRLGPSDYF-G-E-IALLLNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSEIL--------KRNIQRY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFISLTV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >G_aculeatus_ENSGACP00000006172 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MASSST-SSEEERSL--- --QECEQYVQKHNIQQLLKECIIQLCTARPD-RPM--------------NFLRDHFER-- -------LQK----EEAQQIAA-------------------------------------- -----------------------QQRSG-SRSDSREEEV----------S--PPM----- --------------------NPVVRG-RTRR-GA--ISAEVYTEE---DAA----SYVR- ------------------------------KVIPKDYKTMAALAKAMEKNVLFAHL-DDN E-RSDIFDAMFSVNYI----AGETVIQQG--DEGDNFY--VI-D--VGEMDVYV-NN--- ---ELVTSIGEGGSFGELALIYGTPRAATV--RAKSN-VKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLDKWERLTVADALEIVPFVDRQKIVVQGEPGDEFFIIL EGTAAVLQRRSE------DEEFVEVGRLGPSDYF-G-E-IALLMNRPRAATVVACGP--L KCVKLDRPRFERVLGPCSDIL--------KRNIEQY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFVSLSV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >D_rerio_ENSDARP00000021027 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MASSST-SSEEERSL--- --RECERYVQKHNIQQLLKDCIVQLCTARPE-RPM--------------AYLRDYFEK-- -------LEL----EEAKQMVS-------------------------------------- -----------------------QQKSS-SRSDSREDEV----------S--PPM----- --------------------NPVVKG-RRRR-GA--ISAEVYTEE---DAT----SYVR- ------------------------------KVIPKDYKTMAALAKAIEKNVLFAHL-DDN E-RSDIFDAMFSVTYI----AGETVIQQG--DEGDNFY--VI-D--QGEMDVYV-NN--- ---EWVTSIGEGGSFGELALIYGTPRAATV--RAKTN-VKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLDKWERLTVADALETVQFEDGQKIVVQGQPGDEFFIIL EGSAAVLQRRSE------NEEFVEVGRLAPSDYF-G-E-IALLMNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSDIL--------KRNIQQY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFVSLSV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >O_latipes_ENSORLP00000010584 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------KMATSSSTLEEDESL--- --KSCEIFVQKHNIQQILKECIVNLCIAKPE-RPM--------------KFLREHFEK-- -------LEK----EECKHIMA-------------------------------------- -----------------------RQKSN-SQSDSHDDEV----------SP-PPP----- --------------------NPVVKA-RRRR-GG--VSAEVYTEE---DAV----SYVR- ------------------------------KVIPKDYKTMTALAKAISKNVLFAHL-DDN E-RSDIFDAMFPVTHI----AGETVIQQG--DEGDNFY--VI-D--QGEVDVYV-NG--- ---ELVTNIGEGGSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLDKWERLTVADALEPVQFEDGEKIVVQGEPGDDFFIIT EGIASVLQRRSD------NEEYVEVGRLGPSDYF-G-E-IALLLNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSEIL--------KRNIQRY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFISLTV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >C_familiaris_ENSCAFP00000031475 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MAGPARRPARRRRGTGCAAGSAHPGHPPALGRRT AAADPPRPPPPPG--PGSRRSLPAPGPLPRRGPRGGVAHLSSETPHVGPPGRGGGWGRKG REKRQRRRGRRGGEGPRREAENSAEVDYRFMGLSDLPKCLRTMASGSTATSEEERSL--- --RECELYVQKHNIQALLKDSIVQLCTARPE-RPM--------------AFLREYFER-- -------LEK----EEAKQIQN-------------------------------------- -----------------------LQKAS-SRADSREDEI----------SP-PPP----- --------------------NPVVKG-RRRR-GA--ISAEVYTEE---DAA----SYVR- ------------------------------KVIPKDYKTMAALAKAIEKNVLFSHL-DDN E-RSDIFDAMFPVSFI----AGETVIQQG--DEGDNFY--VI-D--QGEMDVYV-NN--- ---EWATSVGEGGSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIIL EGSAAVLQRRSE------NEEFVEVGRLGPSDYF-G-E-IALLMNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSDIL--------KRNIQQY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFVSLSV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >G_aculeatus_ENSGACP00000015074 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MATSSSTLEEDESL--- --KGCEIFVQKHNIQQILKECIVNLCIAKPE-RPM--------------KFLREHFEK-- -------LEK----EECKQIMA-------------------------------------- -----------------------RQKSN-SQSDSHDDEV----------SP-PPP----- --------------------NPVVKA-RRRR-GG--VSAEVYTEE---DAV----SYVR- ------------------------------KVIPKDYKTMTALAKAISKNVLFAHL-DDN E-RSDIFDAMFPVTHI----AGETVIQQG--DEGDNFY--VI-D--QGEVDVYV-NG--- ---EWVTSIGEGGSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLDKWERLTVADALEPVQFEDGEKIVVQGEPGDDFFIIT EGIASVLQRRSD------NEEYVEVGRLGPSDYF-G-E-IALLLNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSEIL--------KRNIQRY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFISLTV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >T_rubripes_ENSTRUP00000042610 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VMASGST-SSEEERSL--- --RECEQYVQKHNIQQLLKDCIVQLCTSRPD-RPM--------------AFLREYFER-- -------LEK----EEVKQIQN-------------------------------------- -----------------------QQKASNSRSDSRDEEV----------S--PPM----- --------------------NPVVKG-RRRR-GA--FSAEVYTEE---DAA----SYVR- ------------------------------KVIPKDYKTMAALAKAIEKNVLFSHL-DDN E-RSDIFDAMFPVTYI----AGETVILQG--DEGDNFY--VI-D--QGEMDVYV-NN--- ---EWVTSIGEGGSFGELALIYGTPRAATV--RAKTN-VKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--RK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIIL EGSAAVLQRRSE------NEEFVEVGRLGPSDYF-G-E-IALLMNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSDIL--------KRNIQQY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFVSLSV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >M_musculus_ENSMUSP00000020932 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MTGPSPEPRVLRGSTQDARSVHQEHLSIRLRSAV VDPLGPPPLPTAGISLSAQRPVTPSPSLPSHSTQGGVAHLSPNRPTWVCGRR-----VEG REKRQRRGGRQTQEPPRNRGE--AEISEQLNNLEDPPPHLRTMASGSMATSEEERSL--- --RECELYVQKHNIQALLKDSIVQLCTTRPE-RPM--------------AFLREYFER-- -------LEK----EEARQIQC-------------------------------------- -----------------------LQKTG-IRTDSREDEI----------SP-PPP----- --------------------NPVVKG-RRRR-GA--ISAEVYTEE---DAA----SYVR- ------------------------------KVIPKDYKTMAALAKAIEKNVLFSHL-DDN E-RSDIFDAMFPVSFI----AGETVIQQG--DEGDNFY--VI-D--QGEMDVYV-NN--- ---EWATSVGEGGSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIIL EGTAAVLQRRSE------NEEFVEVGRLGPSDYF-G-E-IALLMNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSDIL--------KRNIQQY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFVSLSV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >E_caballus_ENSECAP00000000501 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MASGST---EEERSL--- --RECELYVQKHNIQALLKDSIVQLCTARPE-RPM--------------AFLREYFER-- -------LEK----EEAKQIQN-------------------------------------- -----------------------LQKAG-TRADSREDEI----------SP-PPP----- --------------------NPVVKG-RRRR-GA--ISAEVYTEE---DAA----SYVR- ------------------------------KVIPKDYKTMAALAKAIEKNVLFSHL-DDN E-RSDIFDAMFPVSFI----AGETVIQQG--DEGDNFY--VI-D--QGEMDVYV-NN--- ---EWATSVGEGGSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIIL EGSAAVLQRRSE------NEEFVEVGRLGPSDYF-G-E-IALLMNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSDIL--------KRNIQQY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFVSLSV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >B_taurus_ENSBTAP00000011371 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TMASGTT-ASEEERSL--- --RECELYVQKHNIQALLKDSIVQLCTARPE-RPM--------------AFLREYFEK-- -------LEK----EEAKQIQN-------------------------------------- -----------------------LQKAG-SRADSREDEI----------SP-PPP----- --------------------NPVVKG-RRRR-GA--ISAEVYTEE---DAA----SYVR- ------------------------------KVIPKDYKTMAALAKAIEKNVLFSHL-DDN E-RSDIFDAMFPVSFI----AGETVIQQG--DEGDNFY--VI-D--QGEMDVYV-NN--- ---EWATSVGEGGSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIIL EGSAAVLQRRSE------NEEFVEVGRLGPSDYF-G-E-IALLMNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSDIL--------KRNIQQY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFVSLSV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >M_mulatta_ENSMMUP00000002929 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MESGSTAASEEARSL--- --RECELYVQKHNIQALLKDSIVQLCTARPE-RPM--------------AFLREYFER-- -------LEK----EEAKQIQN-------------------------------------- -----------------------LQKAG-TRTDSREDEI----------SP-PPP----- --------------------NPVVKG-RRRR-GA--ISAEVYTEE---DAT----SYVR- ------------------------------KVIPKDYKTMAALAKAIEKNVLFSHL-DDN E-RSDIFDAMFSVSFI----AGETVIQQG--DEGDNFY--VI-D--QGETDVYV-NN--- ---EWATSVGEGGSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIIL EGSAAVLQRRSE------NEEFVEVGRLGPSDYF-G-E-IALLMNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSDIL--------KRNIQQY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFVSLSV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >T_guttata_ENSTGUP00000004221 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MAASSSSSSEEERSL--- --RECELYIQKHNIQQLLKDCIVQLCTVRPE-RPM--------------GFIREYFER-- -------LEK----EETKQLLN-------------------------------------- -----------------------QLKSG-SRSDSREDEI----------SPPPPL----- --------------------NPVVKY-RSRR-GA--ISAEVYTEE---DAA----SYVR- ------------------------------KVIPKDYKTMAALAKAIEKNVLFTHL-DDN E-RSDIFDAMFPVTYI----AGETVIQQGKSDEGDNFY--VV-D--QGEMDVYV-NS--- ---EWATSVGEGGSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GNTL RKRNMYEKFL--SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIIL EGTAAVLQRRSE------NEEFVEVGRLGPSDYF-G-E-IALLMNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSDIL--------KRNIQQY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFVSLSV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >H_sapiens_ENSP00000351410 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MESGSTAASEEARSL--- --RECELYVQKHNIQALLKDSIVQLCTARPE-RPM--------------AFLREYFER-- -------LEK----EEAKQIQN-------------------------------------- -----------------------LQKAG-TRTDSREDEI----------SP-PPP----- --------------------NPVVKG-RRRR-GA--ISAEVYTEE---DAA----SYVR- ------------------------------KVIPKDYKTMAALAKAIEKNVLFSHL-DDN E-RSDIFDAMFSVSFI----AGETVIQQG--DEGDNFY--VI-D--QGETDVYV-NN--- ---EWATSVGEGGSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIIL EGSAAVLQRRSE------NEEFVEVGRLGPSDYF-G-E-IALLMNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSDIL--------KRNIQQY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFVSLSV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >D_rerio_ENSDARP00000024266 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MASGSV-SSEEEKSL--- --RECEVYVQKHNVQQLLKDCIVQLCTSRPD-RPM--------------AFLREYFER-- -------LEK----EESKQLLN-------------------------------------- -----------------------QQKAS-SRSDSREDEV----------S--PPM----- --------------------NPVVKG-RRRR-GA--ISAEVYTEE---DAA----SYVR- ------------------------------KVIPKDYKTMAALAKAIEKNVLFSHL-DDN E-RSDIFDAMFPVTYI----AGEIVIQQG--DEGDNFY--VI-D--QGEMDVYV-NN--- ---EWATSIGEGGSFGELALIYGTPRAATV--RAKTN-VKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLDKWERLTVADALEPVQFEDSQKIVVQGEPGDEFFIIL EGCAAVLQRRSE------NEEFVEVGRLGPSDYF-G-E-IALLMNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSDIL--------KRNIQQY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFVSLSV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >O_cuniculus_ENSOCUP00000014966 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MASGSTAASEEERSL--- --QECELYVQKHNIRALLKDSIVQLCTARPE-RPM--------------AFLREYFER-- -------LEK----EEAKQIQN-------------------------------------- -----------------------LQKAG-TRTDSREDEI----------SP-PPP----- --------------------NPVVKG-RRRR-GA--ISAEVYTEE---DAA----SYVR- ------------------------------KVIPKDYKTMAALAKAIEKNVLFSHL-DDN E-RSDIFDAMFPVSFI----AGETVIQQG--DEGDNFY--VI-D--QGEMDVYV-NN--- ---EWATSVGEGGSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIIL EGSAAVLQRRSE------NEEFVEVGRLGPSDYF-G-E-IALLMNRPRAATVVARGP--L KCVKQDRPRFERVLGPCSDIL--------KRNIQQY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFVSLSV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >G_aculeatus_ENSGACP00000012860 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MASGST-SSEEERSL--- --RECEQYVQKHNIQQLLKDCIVQLCTSRPD-RPM--------------AFLREYFER-- -------LEK----EEAKQIQN-------------------------------------- -----------------------QQKAGSSRSDSRDEEV----------S--PPM----- --------------------NPVVKG-RRRR-GA--FSAEVYTEE---DAA----SYVR- ------------------------------KVIPKDYKTMAALAKAIEKNVLFSHL-DDN E-RSDIFDAMFPVTYI----AGETVILQG--DEGDNFY--VI-D--QGEMDVYV-NN--- ---DWVTSIGEGGSFGELALIYGTPRAATV--RAKTN-VKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--RK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIIL EGSAAVLQRRSE------NEEFVEVGRLGPSDYF-GSE-IALLMNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSDIL--------KRNIQQY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFVSLSV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >A_carolinensis_ENSACAP00000013014 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TMAASGSSSSEEDRSL--- --RECEQYVQKHNIQQLLKDCIVQLCTVRPE-RPM--------------VFLREHFEK-- -------LEK----EETKQFLT-------------------------------------- -----------------------QQK---SRTDSREDEI----------SPPPPM----- --------------------NPVVKG-RRRR-GA--ISAEVYTEE---DAA----SYVR- ------------------------------KVIPKDYKTMAALAKAIEKNVLFAHL-DDN E-RSDIFDAMFPVTYI----AGETVIQQG--KEGNNFY--VI-D--QGEMDVYV-NN--- ---EWATSVGEGGSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIIL EGTAAVLQRRSE------HEEFVEVGRLAPSDYF-G-E-IALLMNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSDIL--------KRNIQQY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFVSLSV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >P_pygmaeus_ENSPPYP00000010056 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MESGSTAASEEARSL--- --RECELYVQKHNIQALLKDSIVQLCTARPE-RPM--------------AFLREYFER-- -------LEK----EEAKQIQN-------------------------------------- -----------------------LQKAG-TRTDSREDEI----------SP-PPP----- --------------------NPVVKG-RRRR-GA--ISAEVYTEE---DAA----SYVR- ------------------------------KVIPKDYKTMAALAKAIEKNVLFSHL-DDN E-RSDIFDAMFSVSFI----AGETVIQQG--DEGDNFY--VI-D--QGETDVRF-TN--- ----IKNIVGEGGSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIIL EGSAAVLQRRSE------NEEFVEVGRLGPSDYF-G-E-IALLMNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSDIL--------KRNIQQY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFVSLSV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >T_rubripes_ENSTRUP00000007339 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MATSSSTIDEDDSL--- --KGCEIFVRKHNIQQILKECIVNLCITKPE-RPM--------------KFLREHFEK-- -------LEK----EECKQIMA-------------------------------------- -----------------------RQKSN-SQSDSHDDEV----------SP-PPP----- --------------------NPVVKA-RRRR-GG--VSAEVYTEE---DAV----SYVR- ------------------------------KVIPKDYKTMTALARAISKNVLFAHL-DDN E-RSDIFDAMFPVTHI----AGETVIQQG--DEGDNFY--VI-D--QGEVDVYV-NG--- ---ELVTNIGEGGSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSILAESLDKWERLTVADALEPVQFEDGEKIVVQGAPGNDFFIIT EGIASVLQRRSD------NEEYVEVGRLGPSDYF-G-E-IALLLNRPRAATVVARGP--L KCVKLDRIRFERVLGPCSEIL--------KRNIQRY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFISLTV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >P_troglodytes_ENSPTRP00000045750 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MESGSTAASEEARSL--- --RECELYVQKHNIQALLKDSIVQLCTARPE-RPM--------------AFLREYFER-- -------LEK----EEAKQIQN-------------------------------------- -----------------------LQKAG-TRTDSREDEI----------SP-PPP----- --------------------NPVVKG-RRRR-GA--ISAEVYTEE---DAA----SYVR- ------------------------------KVIPKDYKTMAALAKAIEKNVLFSHL-DDN E-RSDIFDAMFSVSFI----AGETVIQQG--DEGDNFY--VI-D--QGETDVYV-NN--- ---EWATSVGEGGSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFI-- -GSAAVLQRRSE------NEEFVEVGRLGPSDYF-G-E-IALLMNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSDIL--------KRNIQQY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFVSLSV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >G_gallus_ENSGALP00000006731 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MATSSSSSSEEERSL--- --RECELYVQKHNIQQLLKDCIVQLCTVRPD-RPM--------------GFLREYFER-- -------LEK----EETKQLLN-------------------------------------- -----------------------QQKSG-SRSDSREDEI----------SPPPPM----- --------------------NPVVKG-RRRR-GA--ISAEVYTEE---DAA----SYVR- ------------------------------KVIPKDYKTMAALAKAIEKNVLFAHL-DDN E-RSDIFDAMFPVTYI----AGETVIQQGKCDEGDNFY--VV-D--QGEMDVYV-NN--- ---EWATSVGEGGSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILMASGSTL RKRKMYEEFL--SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIIL EGTAAVLQRRSE------NEEFVEVGRLAPSDYF-G-E-IALLMNRPRAATVVARGL--L KCVKLDRPRFERVLGPCSDIL--------KRNIQQY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFVSLSV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >T_nigroviridis_ENSTNIP00000015837 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MASGST-SSEEERSL--- --RECEQYVQKHNIQQLLKDCIVQLCTSRPD-RPM--------------AFLREYFER-- -------LEK----EEAKQIQN-------------------------------------- -----------------------QQKASNSRSDSRDEEV----------S--PPM----- --------------------NPVVKG-RRRR-GA---SAEVYTEE---DAA----TYVR- ------------------------------KVIPKDYKTMAALAKAIEKNVLFAHL-DDN E-RSDIFDAMFPVTYI----AGETVILQG--DEGDNFY--VI-D--QGEMDVYV-NN--- ---EWVTSIGEGGSFGELALIYGTPRAATV--RAKTN-VKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--RK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIIL EGSAAVLQRRSE------NEEFVEVGRLGPSDYFAG-E-IALLMNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSDIL--------KRNIQQY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFVSLSV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >T_nigroviridis_ENSTNIP00000021133 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------Q----EECKQIMA-------------------------------------- -----------------------RQKSN-SQSDSHDDEV----------SP-PPP----- --------------------NPVVKA-RRRR-GG--VSAEVYTEE---DAV----SYVR- ------------------------------KVIPKDYKTMTALARAISKNVLFAHL-DDN E-RSDIFDAMFPVTHI----AGETVIQQG--DEGDNFY--VI-D--QGEVDVYV-NG--- ---ELVTNIGEGGSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLDKWERLTVADALEPVQFEDGEKIVVQGAPGNDFFIIT EGIASVLQRRSD------NEEYVEVGRLGPSDYFAG-E-IALLLNRPRAATVVARGP--L KCVKLDRIRFERVLGLCSEIL--------KRNIQRY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFISLTV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >D_melanogaster_FBpp0099624 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MSYMMAKTLEEQSL--- --RECEHYIQTHGIQRVLKDCIVQLCVCRPE-NPV--------------QFLRQYFQK-- -------LER----EQVKLDAS-------------------------------------- -----------------------RQV---ISPDDC-EDL----------S--PMP----- --------------------QTAAPP-VRRR-GG--ISAEPVTEE---DAT----NYVK- ------------------------------KVVPKDYKTMNALSKAIAKNVLFAHL-DES E-RSDIFDAMFPVNHI----AGENIIQQG--DEGDNFY--VI-D--VGEVDVFV-NS--- ---ELVTTISEGGSFGELALIYGTPRAATV--RAKTD-VKLWGIDRDSYRRILM--GSTI RKRKMYEEFL--SR-VSIL-ESLDKWERLTVADSLETCSFDDGETIVKQGAAGDDFYIIL EGCAVVLQQRSE------GEDPAEVGRLGSSDYF-G-E-IALLLDRPRAATVVARGP--L KCVKLDRARFERVLGPCADIL--------KRNITQY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFVSLSV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >O_anatinus_ENSOANP00000011151 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KCLLITTLTQILNPAPK-NPV--------------KAGRKYFEG-- -------LQ-----EECKQILA-------------------------------------- -----------------------RQKSN-SQSDSHDDEI----------SP-PPP----- --------------------NPVVKA-RRRR-GG--VSAEVYTEE---DAV----SYVR- ------------------------------KVIPKDYKTMTALAKAISKNVLFAHL-DDN E-RSWIFFSLVPHFWVNFALAYILCLVLG--DEGDNFY--VI-D--QGEVDVYV-NG--- ---EWVTSIGEGGSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLDKWERLTVADALEPVQFEDGEKIVVQGEPGDDFFIIT EGTASVLQRRSD------NEEYVEVGRLGPSDYF-G-E-IALLLNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSEIL--------KRNIQRY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFISLTV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >A_aegypti_AAEL015314-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------PLVNRYASRR-KS--VFAETYDPEAD-DDD----DGAR- ------------------------------AIFPKTDEQRARLCDSVKNILLFRSL-DKE Q-MNEVLDAMFEKKVK----AKDYIIKQG--DDGDNFY--VI-E--SGIYKAYV-GE--- -DQKHIHTYDNSGSFGELALLYNMPRAATI--QAETD-GQLWAMDRQTFRRILL--KSAF RKRKMYEALL--DA-VPML-KTLQSYERMNLADALIPKTFAKGERIIKQG---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >D_rerio_ENSDARP00000095574 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------NEASQVGTQKSLLSLHC-INN DFSSDIFDAMFPVTHI----AGETVIQQG--DEGDNFY--VI-D--QGEVDVYV-NG--- ---EWVTSIGEGGSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLDKWERLTVADALEPVQFEDGEKIVVQGEPGDDFFIII EGTASVLQRRSD------NEEYVEVGRLGPSDYF-G-E-IALLLNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSEIL--------KRNIQRY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFISLTV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >X_tropicalis_ENSXETP00000002916 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---SDIFDAMFPVNHI----AGETVIQQG--DEGDNFY--VI-D--QGEADVYV-NG--- ---EWVTNIGEGGSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLDKWERLTVADALEPVQFEDGEKIVVQGEPGDDFFIIT EGTASVLQRRSD------NEEYVEVGRLGPSDYF-G-E-IALLLNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSEIL--------KRNIQRY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFISLTV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >C_elegans_R07E4.6c M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------NNYSGDIVFMSGGNEEDQL--- --AQCQAYVQRHNIQQLVKEAIVVLCIHKPD-NPV--------------LFLKDHFEK-- -------LNE----QRAQEG---------------------------------------- -----------------------------GNPDAADDDD-------------IIV----- --------------------EPPKRS-GGRR-TG--ISAEPIKED---DT-----EYKK- ------------------------------VVIPKDDATRRSLESAMRKNLLFAHL-EED E-QKTMYDAMFPVEKS----AGETIIEQG--EEGDNFY--VI-D--KGTVDVYV-NH--- ---EYVLTINEGGSFGELALIYGTPRAATV--IAKTD-VKLWAIDRLTYRRILM--GSVT KKRKMYDEFL--SK-VQIL-ADLDQWERANVADALERCDFEPGTHVVEQGQPGDEFFIIL EGEANVLQKRSD------DAPFDVVGHLGMSDYF-G-E-IALLLDRPRAATVVAKTH--L KCIKLDRNRFERVMGPVREIL--------KRDVSNY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSYVKLMT------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >O_anatinus_ENSOANP00000012829 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MASGSS-SSEEERSL--- --RECEHYVQKHNIQALLKDCIVQLCTSRPE-RPM--------------AFLREIFEK-- -------LEK----EEAKQLQN-------------------------------------- -----------------------LQKAS-SRSDSREDEI----------SPPPPM----- --------------------NPVVKG-RRRR-GA--ISAEVYTEE---DAA----SYVR- ------------------------------KVIPKDYKTMAALAKAIEKNVLFAHL-DDN E-RSDIFDAMFPVTYI----AGETVIQQG--DEGDNFY--VV-D--QGEMDVYV-NN--- ---EWATSVGEGGSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIIL EGSAAVLQRRSE------NEEFVEVGRLGPSDYF-G-E-IALLMNRPRAATVVARGP--L KCVKLDRPRFERP----GSLL--------GHPQAKH------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PAVQQLRL------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------AVRLKRRSPARSRLH-------------------------- -----------------------------------------QRRLLSLLHS------- >A_gambiae_AGAP006448-PB ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MSNAQEEEQHL--- --RECESYIQTHCIQRLLKDCIVQLCVSRPE-NPI--------------VFLRQYFQK-- -------LER----EQAKLDAS-------------------------------------- -----------------------KQA---VTPDDL-DDL----------S--PMP----- --------------------QTAVPP-VRRR-GG--ISAEPVTEE---DAT----SYVK- ------------------------------KVVPKDYKTMAALSKAIAKNVLFSHL-DEN E-RSDIFDAMFPCNFL----PGEPIIQQG--DEGDNFY--VI-D--IGEVEVFV-NN--- ---EQVTTISEGGSFGELALIYGTPRAATV--RAKTD-VKLWGIDRDSYRRILM--GSTI RKRKMYEEFL--SR-VSIL-ESLDKWERLTVADALEPVSFEDGETIVRQGEPGNDFYIIV EGCATVMQKRGD------SEEAAEVGRLGPSDYF-G-E-IALLLDRPRAATVIARGP--L KCVKLDRARFERVLGLCADIL--------KRNITQY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFVSLSV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >A_aegypti_AAEL002277-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MFDQLKK---------------------------------KVYRRQ-- -------QKL----EQAKLDAS-------------------------------------- -----------------------KQA---ASPDDL-DDL----------S--PMP----- --------------------QTTAPP-VRRR-GG--ISAEPVSEE---DAT----SYVK- ------------------------------KVVPKDYKTMAALSKAIAKNVLFAHL-DEN E-RSDIFDAMFPCTFL----PGESIIQQG--DEGDNFY--VI-D--IGEVEVFV-NN--- ---ELVTTISEGGSFGELALIYGTPRAATV--RAKTD-VKLWGIDRDSYRRILM--GSTI RKRKMYEEFL--SR-VSIL-ESLDKWERLTVADALEPVSFEDGETIVRQGEPGNDFYIIV EGCATVRQKRDE------NEEPAEVGRLGPSDYF-G-E-IALLLDRPRAATVIARGP--L KCVKLDRARFERVLGLCADIL--------KRNITQY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFVSLSV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >M_domestica_ENSMODP00000005486 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------IMATSGASSEEERSL--- --RECELYVQKHNIQALLKDSIVQLCTVRPD-RPM--------------AFLREYFER-- -------LEK----EESKQLQALALP---------------------------------- -----------------------VQKAV-ILAETREEEI----------SP-PPP----- --------------------NPVVKG-RRRR-GA--ISAEVYTEE---DAA----SYVR- ------------------------------KVIPKDYKTMAALAKAIEKNVLFSHL-DDN E-RSDIFDAMFPASFI----AGETVIQQG--DEGDNFY--VI-D--QGEMDVYV-NN--- ---EWATSVGEGGSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIIL EGSAAVLQRRSE------NEEFVEVGRLGPSDYF-G-E-IALLMNRPRAATVVARGP--L KCVKLDRPRFERP----RPLL--------RHPQTQH------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PAVQQLCV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------TICLKFGSLA------------------------------- ---------------------------------------------------------- >O_latipes_ENSORLP00000004817 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MASGST-SSEEERSL--- --RECEQYVQKHNIQQLLKDCIVQLCTSRPD-RPM--------------AFLREYFER-- -------LEK----EEAKQIQN-------------------------------------- -----------------------QQKAGSSRSDSRDEEV----------S--PPM----- --------------------NPVVKG-RRRR-GA--FSAEVYTEE---DAA----SYVR- ------------------------------KVIPKDYKTMAALAKAIEKNVLFAHL-DDN E-RSDIFDAMFPVTYI----AGETVILQG--DEGDNFY--VI-D--QGEMDVYV-NN--- ---EWVTSIGEGGSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--RK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIIL EGSAAVLQRRSE------HEEFVEVGRLGPSDYF-G-E-IALLMNRPRAATVVARGP--L KCVKLDRPRFE---GP-GPLL--------GHTQTQH------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PTVQQLCV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------AVRLRERLSSPSLLP-------------------------- -----------------------------------------SPLTLRPLRP------- >C_intestinalis_ENSCINP00000005337 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ICDITMAGEEEQGL--- --KECEAYVHEHKIQQTLKDCIVQLCIHKPE-KPM--------------KFLREHFEA-- -------LEK----EEAAPPSP-------------------------------------- -----------------------SSTNEKSNQESGEEEP----------AVTPP------ ---------------------TKLFQ-TQRR-GA--VSAEVYTDD---DQS----PKSNS HLNNVKLIFPPIKLSFYKQPQQLCPKPQSFQVITKDYKTMASLSKAIEKNVLFAHL-DDN E-RSDIFDAMFPVQHI----AGEYIIKQG--DDGDNFY--VM-D--QGEVDIII-NN--- ---NYITTLGDGASFGELALIYGTPRAADV--RAKTD-LKLWAIDRDSYRRILM--GSTL KKRKMYDEFL--SK-VSIL-ESLDKWERLTVADALEPAQFESGQEVVVQGDSGSDFYIIV EGTAAVLQRRSD------NEEYTQVGTLGASDYF-G-E-IALLLDRPRAATVVARSV--L KCVKLDRPRFERVLGECSEIL--------KRNIQQY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSYVSLSV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >E_caballus_ENSECAP00000003303 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MFPVTHI----AGETVIQQG--DEGDNFY--VM-D--QGEVDVYV-NG--- ---EWVTSISEGGSFGELALIYGTPRAATV--KAKTD-LKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLEKWERLTVADALEPVQFEDGEKIVVQGQPGDDFFIIT EGTASVLQRRSP------NEEYMEVGRLGPSDYF-G-E-IALLLNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSEIL--------KRSIQRY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFISLTV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >S_cerevisiae_YIL033C MV---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSLP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------KESQAELQLFQNEINAANPS-DFL--------------QFSANYFNK-- -------RLE----QQRAFLKAREPEFKAKNIVLFPEPE-ESFSRPQSAQSQSRSRSSVM FKSPFVNEDPHSNVFKSGFNLDPHEQDTHQQAQEEQQHTRE--------KTSTPP----- --------------------LPMHFN-AQRR-TS--VSGETLQPNN--FDD----WTPD- ------------------------------HYKEKSEQQLQRLEKSIRNNFLFNKL-DSD S-KRLVINCLEEKSVP----KGATIIKQG--DQGDYFY--VV-E--KGTVDFYV-ND--- ---NKVNSSGPGSSFGELALMYNSPRAATV--VATSD-CLLWALDRLTFRKILL--GSSF KKRLMYDDLL--KS-MPVL-KSLTTYDRAKLADALDTKIYQPGETIIREGDQGENFYLIE YGAVDVSKKGQG-----------VINKLKDHDYF-G-E-VALLNDLPRQATVTATKR--T KVATLGKSGFQRLLGPAVDVL--------KLNDPTR------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------H-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >G_gorilla_ENSGGOP00000011641 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MASPPACPSEEDESL--- --KGCELYVQLHGIQQVLKDCIVHLCISKPE-RPM--------------KFLREHFEK-- -------LEK----EENRQILA-------------------------------------- -----------------------RQKSN-SQSDSHDEEV----------SP-TPP----- --------------------NPVVKA-RRRR-GG--VSAEVYTEE---DAV----SYVR- ------------------------------KVIPKDYKTMTALAKAISKNVLFAHL-DDN E-RXXXXXXXXXXXXX----XXXXXXXXX--NEGDNFY--VI-D--QGEVDVYV-XG--- ---EWVTNISEGGSFGELALIYGTPRAATV--KAKTD-XXXXXXXXXXXXXXXX--GSTL RKRKMYEEFL--SK-VSIL-ESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIIT EGTASVLQRRSP------NEEYVEVGRLGPSDYF-G-E-IALLLNRPRAATVVARGP--L KCVKLDRPRFERVLGPCSEIL--------KRNIQRY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NSFISLTV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >T_nigroviridis_ENSTNIP00000014931 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------DED-DED----LEPR- ------------------------------VVNPKTDEQRRRLQEACRDVLLFTTL-DQA TERMSILDVSRVKQFS----DSERIIKQG--DKADCFY--IV-E--SGEVKIMM-RS--- ---KVSCSFPLSTSLFQLCAVHLTSLFPGV--FSLAT-GGI-NVVCVLLRKIIK--NNTL KLLGNTKVFILFSP-VSCL-PGFSVQTNTDQADA-------------------------- --------------------AEVETARCSRGQHF-G-E-LALVTDKPRAASAYAVGD--V KCLVIDAQTFERLLGSCKEIM--------KSNVTQY------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEQLVALF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GSSI------------------------------- ---------------------------------------------------DL----- >X_tropicalis_ENSXETP00000024459 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------QVIPKDYKTMAALAKAIEKNVLFAHL-AGN S-H-DIFDAMFSVTYI----AGETVIQQG--DEGDNFY--VV-D--QGEMDVYV-NN--- ---DWMTSIGEGGSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL-ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIIL EGSAAVLQRRSE------NEEFVEVGRLGPSDYF-G-E---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >T_rubripes_ENSTRUP00000047709 TGTLRD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LQLALQLKIEELRQRDALIDEL--------------ELELDTKDD-- -------LIR----QLQIE-------LDRYRSSSQQALS-SQ------------------ ---------------------------ETANTGAAVQTVFASD----------------- -----------------------EPL-RIKR-QA--ISAEPSG--LD-PAKL--TDVTL- ------------------------------TSYLKTKESGELIQKALMNNDFMKHL-EHG Q-ILTIMDCMYPTTLS----KGCCVIQEG--DDGSTVY--VL-E--EGMVEVTK-QG--- ---KTLCTIGPGKVFGELAILYNCTRTASV--TALTD-IKLWAIDRQNFQTIMM--RSGV IKHSQYMDFL--RS-IPSF-QSLPEDGLSKLADVLEETHYGDSDYIIRQGATGDTFFIIS EGQVKVSQQNSP------SDEQVTVTTLSKGDWF-G-E-QALKGEDVRTASYTAVG--DV TCLVIDRESFKQLIGGLDEVK--------KKQCENN--------EVKEK----------- -----------------LQAEADFFSSVSLNDFN-------------------------- ---------------------------TICTLGMGGFSRVEL---VQLKNE-TNRSFALK VLKKRHIVDTSQQGHILSERHIMMEAHSPFIVRLYR--------TFKDSKFLYMLLEACL GGELWTLLRDKGSFDDSTTRFYTGCVIEALAFLHTRGIIYRDLKPENIILDNRGYAKLVD FGFAKKVGLGKKTWTFCGTPEYVAPEIILNKGHDSSADCWSLGILIFELLSGSPPFSGSD PMMTYNIILRGIDMIEFP-KKITKSAATLIKRLC-RLSIVHIRINQKNGVKDIQKHKWFE GFNWEGLRQGNIDPPYTPTVDGPQDNSNFDYFPL-------DTDGPPPDEESGWDLEF >A_gambiae_AGAP008585-PA METIKRENIQLGDNRKLVATMGGPLPPSAIGATASSSTVVVRSSPTQPTPPQSVAEASVV NPVTSLCEV---VDQRQAPGEKSVHPQSPTSH------RAWFRKSNTCGSLYVQCGCTVE PGDGTQP-----------NDQQRHSDPAWSSSPPRPPVPTRPISLSDKDIRRIRPRTDKP PFIHPDSPTTVYSGAAVPHDASVRKSHPNRALVPTAQTANGDYEILHTAHSKRYSTPTIG TGYAFHPEFVLQKLGPIGD---EAGGAAQIQSPSPQSEPVRGGAAKVVFKQRSCTSYPGL AEGSEPFGA-------SFSNASSVEEVGSAVVRGQ-------DAEIGALPTLGSFEDLER RQSVSSPPLPQQQQHQPAVTVNDTGGTLDT-TGHCRGVLIESNSNSAGKVSSACAIPARK GRQLFVDSGSDQLSVSLDTGREAHRRSEAAHHQPGAVASCISAENSPPSPPSLLLSPVIP SKFDCSAKEYLIQSGILGPMGNGSSLLMRKTSKIVPNIDTPVKERVSASGSL--ACASGL LVNGLLIRKNSVKFWGK----VLTEDRRKSLTGQ--CDSLQSYGSSMTI-SGTEPNS--- -------------LEEELVGLRRLLRARDDEIDKL--------------RREIDKLKS-- -------VLQ----QKAIN------SLEQTSIPSGQQRL-TLTSPAGTPSHKGQHVAEGE LLSSIQANYAMAGQ--PLSELFGISGNSFKLHQMKSVKGI-------------------- -----------------------TLQ-AMKK-QG--VSGESCD--LM-GSQS--SDIKI- ------------------------------PKYKKDFSAKQLIKDAIMENDFFKNI-DSL Q-IREIVDSMYSREFR----KGEYVIHEG--EAGSHLY--VS-A--AGEFEVIK-DS--- ---KVLGVMGPGRAFGELAILYNCTRTASI--RVLCD-SRVWVLDRRVFQQIMM--RTGM QRIEENVNFL--KS-VPLL-KHLSNDVLTKIADVLEVEFYPAGAFIIRQGAAGDTFFLIS QGTVKVTQRLPG------RSVEEEIRILVRGEYF-G-E-QALIREDKRTANIIAMSP-GV ECLTLDRESFTKHIGDLCELQ--------EKNYGDE--------ERVLAFRNLENTH--P -------S---------LGSCQPELMDVNLTDLE-------------------------- ---------------------------VVGTLGVGGFGRVEL---VKLERNGDTKVYALK CMKKRHIVDTRQQEHMYSERKIMLACQSPFICRLYR--------TYKDAKFVYMLLEACM GGEVWTILRDRVTFEDSTAKFIVACVLQAFDFLHARGIVYRDLKPENLLLDARGYAKLVD FGFSKFIGYSSKTWTFCGTPEYVAPEIILNKGHDRSVDYWALGILIHELLTGIPPFTAAD PMKTYNIILKGIDMVNFP-KHMSRAAVSLIKRLC-RDVPSERLGYQRGGVQDIKKHKWFQ GFDWDGLIALTLKSPLQPNLLGPLDMSNFDIFPK-------DLDI-PPDELSGWDADF >A_aegypti_AAEL005754-PA MATIKNENIQISDN----------------GGPKTNTTPASVTKGMMVTSPSVATAAALI HPLAPLATVPLEVRDETSQNEKSVHSQPSQTSKRQPGLRAWFRKSNTCGSLYVKCSCSNG VPSGGSPQAGSEAVKGTEEGSQRHSHHH----------NTRPISTSEKDFRKIKVL---H AFAHPDTTTVFTDQN---KYANNLSESPTRALITSAQS--GEFEIVHSTHSKRLSTPNFK ADYAFHPEFVLKKLIPKSNGLSQDGKTPSISIPSPRRPVLK----------KSSRSYPGL SPSGSSVDSIERSLVHNHSASSSVDEVTEEEEQGTRRSSEEFTSSQDSYISFSANTELQR DSFSNTNIQKLSLKYAAIKAVSDHEVQEESLTKQQEEIQLEDNSSIQDTVIQCCS----- ------DSACDS-----DNSSNTCNSSDSSPKSPPSVLQHFSRVLSSPTPGSPITSPQTP T-LDRSAQEFFIQSGILGPMGNGSSVLGRKTSKIVPNVDGPVKERCEDACGLTVSCLVLL LAAAHKIRKNSKLLFGKRTIPLSNGDRRKSIPPEHNCDSFQSYGSTPTLGSGTKSKT--- -------------LEDEIHFLRQQLKARDEEISKL--------------KREIDKLKS-- -------VLQ----QTTTS------SLDRSQNAGSGAGG-T-VAPMSSP--KVLQAVEGD LLSSIQANYVMAGQQLPMSELYGITGKGFKLAHSSQLAGIGANDGSFRQNK--------- ---------------------GATLM-AMKK-QG--VSGESCE--LT-GSPS---DIKI- ------------------------------PKYEKDYSAKQLIKDAILENDFFKNI-DSL Q-IREIVDSMYSREFR----SGEYVIHEG--QAGSHLY--VS-A--AGEFEVLK-DG--- ---KFLGLMGPGKAFGELAILYNCTRTASI--RVLSD-SRVWVLDRRVFQQIMM--RTGL QRIEENVNFL--RS-VPLL-KNLSNDVLTKIADVLEVEFYPAGAYIIRQGAAGDSFFLIS QGTVKVTQRLPG------CAVEEEIRILGRGEYF-G-E-KALIKEDKRTANIIAMSP-GV ECLTLDRESFSKHIGDLCELH--------EKDYGDE--------QRVLAFRNLENNNLPS -------S---------LDAVKPELMDVELMDLN-------------------------- ---------------------------VVGTLGVGGFGRVEL---VKLERNGVVQVFALK CMKKKHIVDTKQQEHVFSERKIMLSCHSPFITRLYR--------TYRDDKFVYMLLEACL GGEVWTILRDRSYFEDSTAKFIVGCVLKAFEFLHARGIVYRDLKPENLLLDSRGYVKLVD FGFAKFIGYSSKTWTFCGTPEYVAPEIVLNKGHDRSVDYWALGVLIHELLTGIPPFAAAD PMKTYNIILKGIDMVNFP-KHMSRAAVSLIKRLC-RDVPTERLGYQRGGIQDIKKHKWFQ GFDWEGLANQTLKSPLQPKLKGPLDMSNFDVFPA-------DGHI-PPDEVSGWDEGF >C_intestinalis_ENSCINP00000010398 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------PKTGTQVAQIKRALNSNVFLKGL-DAN Q-VEQLMDCMSLQTVS----AGSEIIAEG--EYGTHMY--VL-D--KGQVKCRSGER--- ---SHVIDLNPGTVFGELAILYNCKRTAYV--EAKTD-VTIWSIDRQLFQTVVK--KSGQ SKRDEYVRLL--RT-VDRL-KSLSENKLLRIADCLEQTTFRMGDYIIRQGDSGDTFYVIQ EGSVKVTQNKTGFFNKMKSREEDFLCNMEKGEYF-G-E-RALLTEDKRAANVIADSD-VV TLLMLDRQAFSSLIGSLAEVGKTPSVPQLPLESEDPSHLDETDGRLRELAVVPEEDEEHV LSEGNHLAPKVTIVTRLSGATESVLKRTKLEDLKVRLHILLSYTVAQFFIGYSVGQFVLQ GCILLFLVRKFIDTAFSAQYAVNRLNAVIRILGQGGFGCVKL---VQVPGL-SNCAFALK AIRQAKIVKTGQQQHVLAEKNIMLAAKSPFIARLYRYTSSAHDTTYKDSSRIYMLMDAYL GGEMYGVLKRMGSLDEIAARFCAGCVLEALSYLHERGIVYRDLKPENLMLDHRGYVKLVD FGFAKRVRFGFKTWTFCGTPEYFPPEILSNAGHDFSADYWSYGILIYELLTRTTPFFAGD DMTVYEGILGGIEGVKFS-KRVKRSAELLIRNLC-KLEPRDRLGYQKGGVNDIRKHRWFH GFDWQGLRTTSIKSPFKVHIKNAVDTNNFEPCLEELADETDDAEV-LRDANMVWAESF >T_nigroviridis_ENSTNIP00000016594 TGTLRD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LQLALQLKIEELRQRDALIDEL--------------ELELDTKDD-- -------LIR----QLQIE-------LDRYRSSSQQALS-SQ------------------ ---------------------------ETANTGAVVQAAPAFD----------------- -----------------------EPL-RIKR-QA--ISAEPSA--LD-PSKL--TDVML- ------------------------------TSYLKTKESGELIQKALMNNDFMKHL-EHG Q-ILTIMDCMYPTSLS----KGCCVIQEG--DDGSTVY--VL-E--EGMVEVTK-QG--- ---KKLCTIGPGKVFGELAILYNCTRTASV--TALTD-IKLWAIDRQNFQTIMM--RSGV IKHSQYMDFL--RS-VPSF-QSLPEDVLSKLADVLEETHYGDSDYIIRQGATGDTFFIIS EGQVKVSQQGSP------SDEQVAVTLLSKGDWF-G-E-QALKGEDVRTASYTAVG--DV TCLVIDRESFKQLIGGLDDVK--------NKQCESN--------EVKAK----------- -----------------LQAEADFFSSVSLKDFN-------------------------- ---------------------------IICTLGMGGFSRVEL---VQLKNE-TNRSFALK VLKKRHIVDTSQQGHILSERQIMMEAHSPFIVRLYR--------TFRDPKYLYMLLEACL GGELWTLLRDRGSFDDSTTRFYTGCVIEALAFLHSGGIIYRDLKPENIILDNRGYAKLVD FGFAKKVGLGKKTWTFCGTPEYVAPEIILNKGHDSSADCWSLGILIFELLSGSPPFSGSD PMMTYNIILRGIDMIEFP-KKITKSAATLIKRLC-RDNPSERLGNQKNGVKDIQKHKWFE GFNWEGLRQGSIDPPYTPTVDGPLDNSNFDYFPE-------DTDS-PPDEESGWDLEF >O_latipes_ENSORLP00000001301 MGN--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G SVKAPRAEE-----------------NSCLPSIHADAPHLDSDILRVRITY--------- -------------LETELARRNQEFQTQELQLRRL------------------------- ----------------QKELETKVSQIEKLQDAIHSHQT-VGLS---------------- ----------------PTALCHHSCRHFSAINQGRFHKVAVEV----------------- -----------------------HRR-LRAK-EG--VSAEPPSADNF-LWRYRPSSVSTA RT----------------------------VHKNSDPSTKRLINEAILSNDFLKKL-EPQ H-MREMVDCMYEKVYS----EGQLVIQEG--DAGNYLY--VL-A--EGLLEVIQ-NG--- ---KLLGEMHPGTAFGELAILYNCKRTATV--KAVLQ-SHIWTLERQTFQTIMM--QTTQ ARHQEYFTFL--RS-VSLL-KQLPEEKLGRIVDCLEVEYFEKGEYIIREGEEGNTFFIIA KGQVTVTQSSEG------FTQPQEIKTLGVGDYF-G-E-RALISEDVRSANIICNEN-DT QCLVVDRDNFNQMVGTYEELQTYLKEYVGELSKSDE--------RRHFLLSLRPHSQQSD -------SPEAQELSRLRERTARIPANQPFQELE-------------------------- ---------------------------VIATLGMGGFGRVEL---VKLKD--EESTFALK CIKKKHVVDTRQQQHIYSEKKILQQTNSSFIIRLFR--------TFRDNKYIYMLLEVCL GGELWTVLRDMSCFEEQTARFCIGCVLEAFDYLHSMGIIYRDLKPENLLLDADGYVKMAD FGFAKQIGIGRKTWTFCGTPEYVAPEVIMNKGHDFGADCWSLGILVFELLTGNPPFSGSD PIKIYTMVLHGIDRVDFP-KRIGKRPDDLIRRLC-KLNPVERIGNKKNGIMDIKKHKWFQ GFNWEGLQGRKLPSPLKRELRGPMDHSNFDMFPP-------NSEE-APDELSGWDKDF >T_nigroviridis_ENSTNIP00000006171 MGTLRD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LQYALQLKIEELRQRDTLIDEL--------------ELELDQKDE-- -------LIQ----RLQNE-------LDKYRSVLRPATA-QQ------------------ -------------------------------VQAQQQSLVLQP----------------- -----------------------DQH-RSKR-QA--ISAEPTA--CD-ISDL--SHVTL- ------------------------------PFYPKSPESKDMIREAILDNDFMKNL-ELS Q-IHEIVDCMYPVEYG----KDACIIEEG--DVGSLVY--VM-E--EGKVEVTK-EG--- ---MKLCTMGPGKVFGELAILYNCTRTATV--RTLVP-VKLWAIDRQCFQTIMM--RTGL IKHAEYMDFL--KS-VPTF-KGLPEETLSKLADVMEETHYEDGDYIIRQGARGDTFFIIS NGKVNVTQEDSS------NQEPVHLRELTRGDWF-G-E-RALQGEDVRTANVIAAD--AV TCLVIDRDSFKHLIGGLEEVS--------NRGYEDL--------EAKAK----------- -----------------YEAENAFFSSLKLNDFN-------------------------- ---------------------------IVDTLGVGGFGRVEL---VQLKKE-EAKTFAMK ILKKRHIVDTRQQEHIRSEKQIMSEAHCDFIVRLYR--------TFKDSKYLYMLMEACL GGELWTILRDRGSFDDSTTRFYTGCVVEAFAYLHAKGIIYRDLKPENLILDSYGYAKLVD FGFAKKISICKKTWTFCGTPEYVAPEIILNKGHDVSADYWSLGILMYELLTGSPPFSGPD PMKTYNIILRGIDMVEFP-KKVTKNASNLIKKLC-RDNPSERLGNQKNGVKDIQKHKWFE GFNWEGLRKGTLTPPITPDVSSPTDTSNFDSFPE-------DTDEPPPDDNSGWDYDF >D_melanogaster_FBpp0077706 MAA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GMLTDREREAIVSN--------- -------------LTKDVQALREMVRSRESELVKL--------------HREIHKLKS-- -------VLQ----QTTNN-------LNVTRNEKAKKKLYSLPEQCGEQESRNQNPHLCS ----------SCGMVLPTSPEFAL--EALSLGPLSPLASTSSASPSGRTSADEVR----- --------------------PKAMPA-AIKK-QG--VSAESCV--QS-MQQS--YSIPI- ------------------------------PKYEKDFSDKQQIKDAIMDNDFLKNI-DAS Q-VRELVDSMYSKSIA----AGEFVIREG--EVGAHLY--VS-A--AGEFAVMQ-QG--- ---KVLDKMGAGKAFGELAILYNCTRTASI--RVLSEAARVWVLDRRVFQQIMM--CTGL QRIENSVNFL--RS-VPLL-MNLSEELLAKIADVLELEFYAAGTYIIRQGTAGDSFFLIS QGNVRVTQKLTPT-----SPEETELRTLSRGDYF-G-E-QALINEDKRTANIIALSP-GV ECLTLDRDSFKRLIGDLCELK--------EKDYGDE--------SRKLAMKQAQESCRDE P----------------KEQLQQEFPDLKLTDLE-------------------------- ---------------------------VVSTLGIGGFGRVEL---VKAHHQDRVDIFALK CLKKRHIVDTKQEEHIFSERHIMLSSRSPFICRLYR--------TFRDEKYVYMLLEACM GGEIWTMLRDRGSFEDNAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVD FGFAKQIGTSSKTWTFCGTPEYVAPEIILNKGHDRAVDYWALGILIHELLNGTPPFSAPD PMQTYNLILKGIDMIAFP-KHISRWAVQLIKRLC-RDVPSERLGYQTGGIQDIKKHKWFL GFDWDGLASQLLIPPFVRPIAHPTDVRYFDRFPC-------DLNE-PPDELSGWDADF >D_rerio_ENSDARP00000085704 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------TKKLINEALMKNDFLKKL-EPQ H-TREMVDCMYEKIYG----AEQLVIQEG--EPGNFLY--VL-A--EGLLEVIQ-NG--- ---KFLGQMRPGTAFGELAILYNCKRTATV--KAVSQ-SHIWALDRQTFQTIMM--RSTQ ARHEEYFSFL--RS-VSLL-KDLPEEKLAKIIDCLEIDYFDKGEYIIREGEEGNTFFIIA KGEVSVTQTTEG------FTEPQEIKTLRVGDYF-G-E-KALISEDVRSANIIAKEN-DT QCLVVDRDNFNEMVGTYEELQ--------ER----------------------------- -------SPEAAELRRLKEKATALSSTSFLKELQ-------------------------- ---------------------------VVATLGMGGFGRVEL---VKLKDS-EDTAFALK CIKKKHIVDTRQQEHIYSEKIILQQTNSNFIVRLFR--------TFRDDKFVYMLLEVCL GGELWSLLRDMSCFDEPTARFCTGCVLEAFDYLHGKGIVYRDLKPENLLLDAEGYVKMAD FGFAKKIGLGKKTWTFCGTPEYVAPEVIMNKGHDFGADCWSLGILIFELLIGSPPFTGSD PIRIYTMVLHGIEKVDIP-KRISKRPEDLIRRLC-KLNPAERLGNKKNGIIDIKKHKWFQ GFNWEGLRRRKLMSPLRRELKGPLDHSYFDMFPP-------ELEE-PPDEFSGWDKDF >O_latipes_ENSORLP00000000450 PGSLRD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LQLALQLKVEELRQRDALIDEL--------------ELELDSKDD-- -------LIR----QLQVE-------LDRYRSTARRGGQ--------------------- ---------------------------DVAYAQKKAYATLYAI----------------- -----------------------ETR-RTKR-HA--FSAEAPP--LD-SAQL--AAVSI- ------------------------------TSYRKSKESRDLIQKALLDNDYMKHL-ERE Q-IASIVDSMYPTSLD----KGSCVTQEG--DVGSTLY--VL-E--EGRVEVTK-QG--- ---RKRSNISGGKVFGELAVLQRCACTATV--TALTN-VRLWAMDRQGFQTVTM--RAGL LRRSRHTDLL--RR-VPWF-QSLPDGVLCRLAEALEETVYSDGDFIIRQGAPGDTFFIVS EGQVKASQQASA------DGERETEWTLSEGDWF-G-E-HALKGEDVRAASVMAVG--GA TCLVIDRESFKRVVGGPDGGP--------DGAPDGGDVGSDGGAEVEFR----------- -----------------QRVESDFISGLSLGHFR-------------------------- ---------------------------IISTLGRGGCSRVDL---VQLEKY-PNRSFALK VLQRSRILQTGQQNRVRSERRILMEAHNPFIVRLYR--------TFRDSRRLYMLLEACL GGDLWSLLQDRGPFDDGATRFYAGCVTEALVYLHHKGIIYRNLKPETILLDLRGYAKLVD FGFAKYVGVGKKTWTFCGTPEYVAPEILLNKGHDGSVDCWALGVLLFELLCGSPPFLASD PLDIYNIILRGIDMIQFP-RKITKSAANLIKGLC-RDRPSERLGNQKNGLRDVQKHKWFD GFDWDGLQQGSIRPPFAPPADGPLVHSDFDSFTE-------DTDEPPPDDGSGWDAEF >T_rubripes_ENSTRUP00000002807 MGTLRD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LQYALQLKIEELRQRDTLIDEL--------------ELELDQKDE-- -------LIQ----RLQNE-------LDKYRSVLRPATA-QQ------------------ -------------------------------VQAQQQSLVLQP----------------- -----------------------DQH-RSKR-QA--ISAEPTA--CD-ISDL--SHVTL- ------------------------------PFYPKSPQSKEMIREAILDNDFMKNL-ELS Q-IHEIVDCMYPVEYG----KDACIIEEG--DVGSLVY--VM-E--EGKVEVTK-EG--- ---MKLCTMGPGKVFGELAILYNCTRTATV--RTLVH-VKLWAIDRQCYQTIMM--RTGL IKHAEYMDFL--KS-VPTF-KGLPEETLSKLADVMEETHYEDGDYIIRQGARGDTFFIIS NGKVNVTQEDPD------NQGPVHLRELTRGDWF-G-E-RALQGEDVRTANVMAAD--AV TCLVIDRDSFKHLIGGLEEVS--------NRGYEDV--------EAKAK----------- -----------------YEAENAFFSGLKLNDFN-------------------------- ---------------------------IVDTLGVGGFGRVEL---VQLKKE-EAKTFAMK ILKKRYIVDTRQQEHIRSEKQIMSEAHCDFIVRLYR--------TFKDRKYLYMLLEACL GGELWTLLRDRGSFDDTTTRFYTGCVVEAFAYLHAKGIIYRDLKPENLLLDSHGYAKLVD FGFAKKIGLCKKTWTFCGTPEYVAPEIILNKGHDVSADYWSLGILMYELLTGSPPFSGPD PMKTYNIILRGIDMVEFP-KKVTKNATNLIKKLC-RDNPSERLGNQKSGVKDIQKHKWFE GFNWEGLRKGTLTPPIRPDVSSPTDTSNFDSFPE-------DTDEPPPDDNSGWDYDF >A_carolinensis_ENSACAP00000010068 MGN--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G SVKHKYLKRQEG--------------HAGNCPP--------RYILRSKVWE--------- -------------LERELKRQEEELHERNYHILEL--------------QDQLAKQTR-- -------TIA----DLTEELKCKCIQLNKLQDVVDTQGT-NP--------FLFS------ ----------------PLK-------------EVPKVSPVPCS----------------- -----------------------NRR-KGAK-EG--VSAEPTSRTYD-LTEQPRFSFEK- ------------------------------ARVRKASSEKKLITEALSRNQFLKRL-DPQ Q-IRDMVECMYGRTYQ----QGSYIIKQG--EPGNHIF--VL-A--EGKVEVFQ-QN--- ---KLLSSIPVWTAFGELAILYNCTRTASV--KAVTI-VKTWALDREVFQNIMR--RTAQ ARHDQYRNFL--RS-VSLL-KNLPEDKLSKIVDCLEVEYYDKGDYIIREGEEGNTFFVIA KGKVKVTQTTDG------QPQTQLIKTLQKGDYF-G-E-RALISDDVRSANIIADEN-DV ECLVVDRETFNQTVGTFEELQAYLAGYVATLARDDE--------KRNAQVSSLERLP--- -------SDVSLEMIQLKEKVAQFPSSCPFQNLE-------------------------- ---------------------------IVATLGVGGFGRVEL---VKLKN--ESIAFAMK CIKKKHIVDTKQQEHIHSEKRILEEACSPFIVRLYR--------TFKDNKYVYMLLEACL GGELWSILRDRGSFDETTTKFCVGCVTEAIEYLHCISVIYRDLKPENLILDAHGYIKLVD FGFAKKIAIGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGAD QMTTYNLILKGVERLDFP-RIVSKRPEDLIRRLC-RQNPTERLGNLKNGIHDIKRHRWLN GFNWEGLKARKLSSPLKRELSGPMDYSYFDRYPP-------DQGI-PPDELSGWDKDF >G_gallus_ENSGALP00000017721 MGN--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A SMKHKHLRQPDR--------------HVANLA---------LGCASHRVLE--------- -------------LEKELKRKDEELQEGQSLVAEL--------------QEQLSVQTK-- -------VIA----ELTKELQSKCIQLNKLQDVINTQGE-HS--------LQPS------ ----------------PFR---------------VTPKNQISA----------------- -----------------------DRR-KGAK-EG--VSAEPTTQLYD-SSKQARFSFEK- ------------------------------SRVRKDSSEKKLITDALNKNQFLKRL-EPQ Q-IREMVECMYERTFQ----QGSYVIRQG--EPGNHIF--VL-K--EGRLEVFQ-QN--- ---KLLSSIPVWTAFGELAILYNCTRTASV--KAITN-VKTWALDREVFQNIMR--VTAQ TRQEQYRNFL--RS-VSLL-KNLPEDKLTKIMDCLEVEYYNKGDYVIREGEEGNTFFIIA KGKVKVTQSTAD------HSQPQLIKNLHKGDYF-G-E-KALISDDVRSANVIADEY-DV ECLVIDRDTFNQTVGTYEELQTYLEGYVANLARADE--------KRHAKRRSFCGQST-- -------KEVSLEMIQLKEKVAQFPSS-PFQNLE-------------------------- ---------------------------VVTTLGVGGFGRVEL---VKVKN--ENVAFAMK CIKKKHVVDTKQQEHIYSEKKILEQICSPFIVKLYR--------TFKDSKYVYMLLEACL GGELWSLLRDRGCFDEPTTKFCVGCVTEALDYLHHIGIVYRDLKPENLILDAEGYIKLVD FGFAKKIGSGQKTWTFCGTPEYVAPEVILSKGHDFSVDFWSLGILVYELLTGSPPFSGAD QMTTYNLILKGIEKLDFP-RTITRRPEDLIRRLC-RQNPTERLGNLRNGINDIKKHRWLN GFNWDGLKLRKLASPLKRELSGPTDYSYFDSYPP-------EEGM-PPDELSGWDKDF >D_rerio_ENSDARP00000071397 MGN--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G SMKLNPLKQVSG----------------SAKSKNNGESSLVPQVLRVRVEE--------- -------------LETHLKKKDEDLNAKELQIKHL--------------EEQLAQQKQ-- -------TLS----EISDTLRSKCLQLNKLQDALKSQGE-LG--------LLPS------ ----------------PLK---------EKVSQGLTGLLRETL----------------- -----------------------NRR-KGAK-AG--VSAEPSSRTYD-SSGIPKFYFES- ------------------------------ARVWKEQSVKKLLTDALNKNQYLRRL-EVQ Q-VKDMVECMYERTYQ----QGEYVIKQG--EPGNHLF--VL-A--DGKLDVYQ-HN--- ---KLLTSIAVWTTFGELAILYNCTRTASV--KAASN-VKTWALDREVFHNIMR--MTAE ARHEQYRNFL--RS-VSLL-ASLPGDKLTKIVDCLEVEYYNKGDYIIREGEEGNTFYIIA NGKIKVTQSTQD------HEEPQIINTLGKGDYF-G-E-KALISDDVRSANIIAEED-GV ECLVIDRETFSQTVGTFDELKKYLQSYVDSLARDDK--------KRNAKRSGSCTPPN-- -------TPVSHDMIELKERESSFASTIPFTCLE-------------------------- ---------------------------AIATLGVGGFGRVEL---VKLKN--ENVTFALK CIKKRHIVDNRQEEHIYSERRILLETNCPFIVKMYR--------TYKDNKYVYMLLEACL GGEIWSLLRDRGSFEEYTAKFCVGCVTEAFDYLHNNGIIYRDLKPENLMLDTDGYVKLVD FGFAKKLKCGQRTWTFCGTPEYVAPEIILNKGHGLSVDFWSLGILIFELLTGSPPFTGSD QMIIYTFILKGIEKMDFP-KKITKRPGDLIRKLC-RQNPSERLGNLKNGITDIKKHRWFT GFSWSGLKARNLISPLKREVKGPTDHSYFDSYPP-------EEEI-PPDEMSGWDTDF >X_tropicalis_ENSXETP00000046551 MGN--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G SMKSKPLKQPDG--------------QRVNFSISSCNKLRNADTVKNKVWE--------- -------------LEIELKKKDEKLKNKEQIFQEL--------------QEQIKKQNQ-- -------VIE----EMAEELQNKCVQLNKLQVVVQTQNG-ISTTPDLHKMLQPS------ ----------------PTKTLHALPTKSLKGSPLKTFSGLFSNS---------------- -----------------------NKR-KGAK-EG--VSAEPTSR-YD-GGDHPRFSFEK- ------------------------------ARVRKNTSEKILISDALNKNQFMKRM-DHH Q-IQDMVECMYERIYL----QGEFIIRQG--EPGSQIF--VL-A--DGKAEVFQ-EN--- ---KLLTSIPVWTTFGELAILYNCTRTASV--KAITG-VRTWALDREVFQNIMR--KTAQ SKHEEYLSFL--RAIVPLL-KELPEHKLMKIADCLELEFYEMDDYIIREGEEGSTFFIIS KGKVKVTQSTEG------YKEPQYIKFLEKGDYF-G-E-KALISDDVRSANILAYGD-RV ECLVMDRETFNKTVGTYEELMKCLEGYVANLTLDDE--------RRHAKSPVNERHL--- -------RAVSMELNKMKQTLARFPSASPFENLE-------------------------- ---------------------------IVTTLGVGGFGRVEL---VKVKN--ENLVFALK CIKKRHIVDNRQQEHIHSEKNILEEACSPFIVKLYC--------TFKDNKYVYMLLEACL GGELWSILRDRGSFDEPTAKFCTGCVTEAFEYLHQKGVLYRDLKPENLLLDSEGYVKLVD FGFAKKIFPGQKTWTFCGTPEYVAPEVILNKGHSFSVDFWSLGILLYELLTGSPPFTGPD QMIIYNLILQGIEKIEFY-KNITKRPEDLIRRLC-RENPAERLGNMKNGIADIKKHRWFN GFNWEGLNTRSLPSPLKPELEGPTDHSYFDSYPP-------DEEI-PPDEVSGWDQDF >X_tropicalis_ENSXETP00000039632 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------LPQ----EEARQTLN-------------------------------------- -----------------------QQKSG-SRSDSREDEI----------SPPPHM----- --------------------NSVVKG-RRRR-GA--ISAEVYTEE---DAA----SYVR- ------------------------------KVIPKDYKTMAALAKAIEKNVLFAHL-DDN E-RSDIFDAMFSVTYI----AGETVIQQG--DEGDNFY--VV-D--QGEMDVYV-NN--- ---DWMTSIGEGGSFGELALIYGTPRAATV--KAKTN-VKLWGIDRDSYRRILM--GSTL RKRKMYEEFL--SK-VSIL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >P_pygmaeus_ENSPPYP00000016617 MGN--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G SVKPKHSKHPDG--------------HSGNLT---------TDALRNKVTE--------- -------------LERELRRKDAEIQEREYHLKEL--------------REQLSKQTV-- -------AIA----ELTEELQNKCIQLNKLQDVVHMQGG-SL--------LQAS------ ----------------PDK---------VPLEVHRKTSGLVSL----------------- -----------------------HSR-RGAK-AG--VSAEPTTRTYD-LNKPPEFSFEK- ------------------------------ARVRKDSSEKKLITDALNKNQFLKRL-DPQ Q-IKDMVECMYGRNYQ----QGSYIIKQG--EPGNHIF--VL-A--EGRLEVFQ-GE--- ---KLLSSIPMWTTFGELAILYNCTRTASV--KAITN-VKTWALDREVFQNIMR--RTAQ ARDEQYRNFL--RS-VSLL-KNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILA KGKVKVTQSTEG------HDQPQLIKTLQKGEYF-G-E-KALISDDVRSANIIAEEN-DV ACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDE--------KRHAKRSMSNWKLS-- -------KALSLEMIQLKEKVARFSSSSPFQNLE-------------------------- ---------------------------IIATLGVGGFGRVEL---VKVKN--ENVAFAMK CIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYR--------TFKDNKYVYMLLEACL GGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVD FGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVD QMMTYNLILKGIEKMDFP-RKITRRPEDLIRRLC-RQNPTERLGNLKNGINDIKKHRWLN GFNWEGLKARSLPSPLQRELNGPIDHSYFDKYPP-------EKGM-PPDELSGWDKDF >H_sapiens_ENSP00000264399 MGN--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G SVKPKHSKHPDG--------------HSGNLT---------TDALRNKVTE--------- -------------LERELRRKDAEIQEREYHLKEL--------------REQLSKQTV-- -------AIA----ELTEELQNKCIQLNKLQDVVHMQGG-SP--------LQAS------ ----------------PDK---------VPLEVHRKTSGLVSL----------------- -----------------------HSR-RGAK-AG--VSAEPTTRTYD-LNKPPEFSFEK- ------------------------------ARVRKDSSEKKLITDALNKNQFLKRL-DPQ Q-IKDMVECMYGRNYQ----QGSYIIKQG--EPGNHIF--VL-A--EGRLEVFQ-GE--- ---KLLSSIPMWTTFGELAILYNCTRTASV--KAITN-VKTWALDREVFQNIMR--RTAQ ARDEQYRNFL--RS-VSLL-KNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILA KGKVKVTQSTEG------HDQPQLIKTLQKGEYF-G-E-KALISDDVRSANIIAEEN-DV ACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDE--------KRHAKRSMSNWKLS-- -------KALSLEMIQLKEKVARFSSSSPFQNLE-------------------------- ---------------------------IIATLGVGGFGRVEL---VKVKN--ENVAFAMK CIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYR--------TFKDNKYVYMLLEACL GGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVD FGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVD QMMTYNLILKGIEKMDFP-RKITRRPEDLIRRLC-RQNPTERLGNLKNGINDIKKHRWLN GFNWEGLKARSLPSPLQRELKGPIDHSYFDKYPP-------EKGM-PPDELSGWDKDF >P_troglodytes_ENSPTRP00000027855 MGN--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G SVKPKHSKHPDG--------------HSGNLT---------TDALRNKVTE--------- -------------LERELRRKDAEIQEREYHLKEL--------------REQLSKQTV-- -------AIA----ELTEELQNKCIQLNKLQDVVHMQGG-SP--------LQAS------ ----------------PDK---------VPLEVHRKTSGLVSL----------------- -----------------------HSR-RGAK-AG--VSAEPTTRTYD-LNKPPEFSFEK- ------------------------------ARVRKDSSEKKLITDALNKNQFLKRL-DPQ Q-IKDMVECMYGRNYQ----QGSYIIKQG--EPGNHIF--VL-A--EGRLEVFQ-GE--- ---KLLSSIPMWTTFGELAILYNCTRTASV--KAITN-VKTWALDREVFQNIMR--RTAQ ARDEQYRNFL--RS-VSLL-KNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILA KGKVKVTQSTEG------HDQPQLIKTLQKGEYF-G-E-KALISDDVRSANIIAEEN-DV ACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDE--------KRHAKRSMSNWKLS-- -------KALSLEMIQLKEKVARFSSSSPFQNLE-------------------------- ---------------------------IIATLGVGGFGRVEL---VKVKN--ENVAFAMK CIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYR--------TFKDNKYVYMLLEACL GGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVD FGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVD QMMTYNLILKGIEKMDFP-RKITRRPEDLIRRLC-RQNPTERLGNLKNGINDIKKHRWLN GFNWEGLKARSLPSPLQRELKGPIDHSYFDKYPP-------EKGM-PPDELSGWDKDF >M_mulatta_ENSMMUP00000026112 MGN--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G SVKPKHSKHPDG--------------HSGNLT---------TDALRNKVTE--------- -------------LERELRRKDAEIQEREYNLKEL--------------REQLSKQTV-- -------AIA----ELTEELQNKCIQLNKLQDVVHMQGG-SP--------LQAS------ ----------------PDK---------VPLEVHRKTSGLVSL----------------- -----------------------HSR-RGAK-AG--VSAEPTTRTYD-LNKPPEFSFEK- ------------------------------ARVRKDSSEKKLITDALNKNQFLKRL-DPQ Q-IKDMVECMYGRNYQ----QGSYIIKQG--EPGNHIF--VL-A--EGRLEVFQ-GE--- ---KLLSSIPMWTTFGELAILYNCTRTASV--KAITN-VKTWALDREVFQNIMR--RTAQ ARDEQYRNFL--RS-VSLL-KNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILA KGKVKVTQSTEG------HDQPQLIKTLQKGEYF-G-E-KALISDDVRSANIIAEEN-DV ACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDE--------KRHAKRSMSNWKLS-- -------KALSLEMIQLKEKVARFSSSSPFQNLE-------------------------- ---------------------------IIATLGVGGFGRVEL---VKVKN--ENVAFAMK CIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYR--------TFKDNKYVYMLLEACL GGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVD FGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGID QMMTYNLILKGIEKMDFP-RKITRRPEDLIRRLC-RQNPTERLGNLKNGINDIKKHRWLN GFNWEGLKARSLPSPLQRELNGPIDHSYFDKYPP-------EKGM-PPDELSGWDKDF >T_guttata_ENSTGUP00000002960 MGN--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R LVKPKHLRQPNR--------------HMANLAIG-------SDVLCSKVLE--------- -------------LEKELKRKDQQLQESQHHVAEL--------------QEQLAMQTK-- -------VIA----ELSNELQSKCIQLNKLQDVISTQGE-HS--------LQPS------ ----------------PFK---------------------VSA----------------- -----------------------DRR-RGAK-EG--VSAEPTTALCD-LSRQTMFSLEK- ------------------------------ATVQKDSSEKKLITDALNRNQFLKRL-EPH Q-TRDMVECMYERTFQ----QGSYVIRQG--EPGNHIF--VL-K--EGSLEVFQ-QN--- ---KLLSSIPVWTAFGELAILYNCTRTASV--KAITN-VKTWALDREVFQNIMR--VTAQ TRQEQYRKFL--RS-VSLL-KNLPEDKLTKIMDCLEVEYYDKGDYVIREGEEGNTFFIIA KGKVIVTQSTTD------HSQPQVIKNLHKGDYF-G-E-KALISDDTRSANVIADEY-NV ECLVIDRETFNQTVGTYEELQTYLEGYVANLAQADE--------KRHAKGRSFCGQLT-- -------KEVSLEMIELKEKVAQFPPS-PFQNLE-------------------------- ---------------------------VVTTLGVGGFGRVEL---VKVKN--ENMAFAMK CIKKKHVVDTKQQEHIYSEKKILEQICSPFVVKLYR--------TFKDNKYVYMLLEACL GGELWSLLRDRGSFDEFTTKFCVGCVTEAFDYLHQIGIIYRDLKPENLILDAEGYIKLVD FGFAKKIGSGQKTWTFCGTPEYVAPEVILSKGHDFSVDFWSLGILVYELLTGSPPFSGAD QMMTYNLILKGIEKLDFP-KVITRRPEDLIRRLC-RQNPTERLGNLRNGINDIKKHRWLS GFNWDSLKVRKLTSPLKRELSGPTDYSYFDSYPP-------EVGS-PPDELSGWDKDF >E_caballus_ENSECAP00000022043 MGN--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G SVKPKHSKHPDG--------------HSGNLT---------TDALQSKVTE--------- -------------LERELRRKDAEIQEREYHLKEL--------------REQLSKQTV-- -------AIA----ELTEELQNKCIQLNKLQDVLHMQGG-SP--------LQAS------ ----------------PDK---------VPLEVHRKTSGLVSL----------------- -----------------------HSR-RGAK-AG--VSAEPTTRTYD-LNKPPEFSFEK- ------------------------------ARVRKDSSEKKLITDALNKNQFLKRL-DPQ Q-IKDMVECMYGRNYQ----QGSYIIKQG--EPGNHIF--VL-A--EGQLEVFQ-GE--- ---KLLSSIPMWTTFGELAILYNCTRTASV--KAITN-VKTWALDREVFQNIMR--RTAQ ARDEQYRNFL--RS-VSLL-KNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILA KGKVKVTQSTEG------HDQPQLIKTLQKGEYF-G-E-KALISEDVRSANIIAEEN-DV ACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDE--------KRHAKRSMSNWKLS-- -------KALSLEMIQLKEKVARFSSSSPFQNLE-------------------------- ---------------------------IIATLGVGGFGRVEL---VKVKN--ENVAFAMK CIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYR--------TFKDNKYVYMLLEACL GGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVD FGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGID QMMTYNLILKGIEKMDFP-RKITRRPEDLIRRLC-RQNPTERLGNLKNGINDIKRHRWLN GFNWEGLKARNLPSPLQRELSGPTDHSYFDKYPP-------EKGV-PPDELSGWDKDF >M_musculus_ENSMUSP00000031277 MGN--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G SVKPKHAKHPDG--------------HSGNLS---------NEALRSKVLE--------- -------------LERELRRKDAELQEREYHLKEL--------------REQLAKQTV-- -------AIA----ELTEELQSKCIQLNKLQDVIHVQGG-SP--------LQAS------ ----------------PDK---------VPLDVHRKTSGLVSL----------------- -----------------------HSR-RGAK-AG--VSAEPTTRTYD-LNKPPEFSFEK- ------------------------------ARVRKDSSEKKLITDALNKNQFLKRL-DPQ Q-IKDMVECMYGRNYQ----QGSYVIKQG--EPGNHIF--VL-A--EGRLEVFQ-GE--- ---KLLSSIPMWTTFGELAILYNCTRTASV--KAITN-VKTWALDREVFQNIMR--RTAQ ARDEEYRNFL--RS-VSLL-KNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILA KGKVKVTQSTEG------HDQPQLIKTLQKGEYF-G-E-KALISDDVRSANIIAEEN-DV ACLVIDRETFNQTVGTFDELQKYLEGYVATLNRDDE--------KRHAKRSMSSWKLS-- -------KALSLEMIQLKEKVARFSSTSPFQNLE-------------------------- ---------------------------IIATLGVGGFGRVEL---VKVKN--ENVAFAMK CIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYR--------TFKDNKYVYMLLEACL GGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDADGYLKLVD FGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGID QMMTYNLILKGIEKMDFP-RKITRRPEDLIRRLC-RQNPTERLGNLKNGINDIKKHRWLN GFNWEGLKARSLPSPLRRELSGPIDHSYFDKYPP-------EKGV-PPDEMSGWDKDF >G_gorilla_ENSGGOP00000006462 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------EKKLITDALNKNQFLKRL-DPQ Q-IKDMVECMYGRNYQ----QGSYIIKQG--EPGNHIF--VL-A--EGRLEVFQ-GE--- ---KLLSSIPMWTTFGELAILYNCTRTASV--KAITN-VKTWALDREVFQNIMR--RTAQ ARDEQYRNFL--RS-VSLL-KNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILA KGKVKVTQSTEG------HDQPQLIKTLQKGEYF-G-E-KALISDDVRSANIIAEEN-DV ACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDE--------KRHAKRSMSNWKLS-- -------KALSLEMIQLKEKVARFSSSSPFQNLE-------------------------- ---------------------------IIATLGVGGFGRVEL---XXXXX--XXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLYR--------TFKDNKYVYMLLEACL GGELWSILRDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPPFSGVD QMMTYNLILKGIEKMDFP-RKIXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXWLN GFXWEGLKARSLPSPLQRE--------------------------------------- >G_aculeatus_ENSGACP00000012095 MGTLRD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LQYALQEKIEELRQRDALIDEL--------------ELELDQKDE-- -------LIQ----RLQTE-------LDKYRSVIKPATQ--------------------- --------------------------------VV-KQN--DLH----------------- -----------------------EQQ-RTKR-QA--ISAEPTA--FD-IQDL--SHVTL- ------------------------------PFYPKSPQSKDLIKEAILDNDFMKNL-ELS Q-IQEIVDCMYPVEYG----KDSCIIKEG--DVGSLVY--VM-E--DGKVEVTK-ES--- ---LKLCTMGPGKVFGELAILYNCTRTATV--KTLTN-VKLWAIDRQCFQTIMM--RTGL IKHTEYMEFL--KS-VPTF-HGLQEDILSKLADVLEETHYGDGEYIIRQGARGDTFFIIS KGKVNVTREDLP------NIEPVYLRSLGKGDWF-G-E-KALQGEDIRTANVIAAE--AV TCLVIDRDSFKHLIGGLEEVS--------SKGHEDA--------DAKAK----------- -----------------YEAENAFFFNLNLADFN-------------------------- ---------------------------IIDTLGVGGFGRVEL---VQLKSD-ENKTFAMK ILKKRHIVDTRQQEHIRSEKLIMQEAHSDFIVRLYR--------TFKDSKYLYMLMEACL GGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVD FGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMFELLTGSPPFSGPD PMKTYNIILRGIDMIEFP-KKITKNAGNLIKKLCSRDNPSERLGNLKNGVKDIQKHKWFE GFNWEGLKKGTLTPPIVPNVTSAVDTSNFDSFPE-------DNEDPPPDDNSGWDVDF >M_musculus_ENSMUSP00000073268 MGTLRD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LQYALQEKIEELRQRDALIDEL--------------ELELDQKDE-- -------LIQ----KLQNE-------LDKYRSVIRPATQ--------------------- --------------------------------QAQKQSASTLQ----------------- -----------------------GEP-RTKR-QA--ISAEPTA--FD-IQDL--SHVTL- ------------------------------PFYPKSPQSKDLIKEAILDNDFMKNL-ELS Q-IQEIVDCMYPVEYG----KDSCIIKEG--DVGSLVY--VM-E--DGKVEVTK-EG--- ---VKLCTMGPGKVFGELAILYNCTRTATV--KTLVN-VKLWAIDRQCFQTIMM--RTGL IKHTEYMEFL--KS-VPTF-QSLPDEILSKLADVLEETHYENGEYIIRQGARGDTFFIIS KGQVNVTREDSP------SEDPVFLRTLGKGDWF-G-E-KALQGEDVRTANVIAAE--AV TCLVIDRDSFKHLIGGLDDVS--------NKAYEDA--------EAKAK----------- -----------------YEAEAAFFANLKLSDFN-------------------------- ---------------------------IIDTLGVGGFGRVEL---VQLKSE-ESKTFAMK ILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYR--------TFKDSKYLYMLMEACL GGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVD FGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPD PMKTYNIILRGIDMIEFP-KKIAKNAANLIKKLC-RDNPSERLGNLKNGVKDIQKHKWFE GFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPE-------DSDEPPPDDNSGWDIDF >R_norvegicus_ENSRNOP00000003237 MGN--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G SVKPKHSKHPDG--------------QSGNLS---------NEALRSKVAE--------- -------------LEREVKRKDAELQEREYHLKEL--------------REQLAKQTV-- -------AIA----ELTEELQSKCIQLNKLQDVIHVQGG-SP--------LQAS------ ----------------PDK---------VPLDVHRKTSGLVSL----------------- -----------------------HSR-RGAK-AG--VSAEPTSRTYD-LNKPPEFSFEK- ------------------------------ARVRKDSSEKKLITDALNKNQFLKRL-DPQ Q-IKDMVECMYGRNYQ----QGSYIVKQG--EPGNHIF--VL-A--EGRLEVFQ-GE--- ---KLLSSIPMWTTFGELAILYNCTRTASV--KAITN-VKTWALDREVFQNIMR--RTAQ ARDEEYRNFL--RS-VSLL-KNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILA KGKVKVTQSTEG------HDQPQLIKTLQKGEYF-G-E-KALISDDVRSANIIAEEN-DV ACLVIDRETFNQTVGTFDELQKYLEGYVATLNRDDE--------KRHAKRSMSSWKLS-- -------KALSLEMIQLKEKVARFSSTSPFQNLE-------------------------- ---------------------------IIATLGVGGFGRVEL---VKVKN--ENIAFAMK CIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYR--------TFKDNKYVYMLLEACL GGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDADGYLKLVD FGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGID QMMTYNLILKGIEKMDFP-RKITRRPEDLIRRLC-RQNPTERLGNLKNGINDIKKHRWLN GFNWEGLKARSLPSPLRRELSGPIDHSYFDKYPP-------EKGV-PPDEMSGWDKDF >B_taurus_ENSBTAP00000003877 MGN--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G SVKPKHSKNPDG--------------HPGNLT---------ASALRSRVTE--------- -------------LERELRRKDAEIQEREYHLKEL--------------REQLSKQTV-- -------AIA----ELTEELQNKCIQLNKLQDVVHLQGG-SL--------PRAS------ ----------------PDK---------VPLEVQRKTSGLVSL----------------- -----------------------HSR-RGAK-AG--VSAEPTTRTYD-LNKPPEFSFEK- ------------------------------ARVRKDSSEKKLITDALNKNQFLKRL-DPQ Q-IKDMVECMYGRNYQ----QGSYIIKQG--EPGNHIF--VL-A--EGRLEVSQ-GE--- ---KLLSSIPMWTTFGELAILYNCTRTASV--KAITN-VKTWALDREVFQNIMR--RTAQ ARDEQYRNFL--RS-VSLL-KNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILA KGKVKVTQSTEG------HDQPQLIKTLQKGEYF-G-E-KALISEDVRSANIIAEEN-DV ACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDE--------KRHAKRSMSSWKLS-- -------KALSLEMIQLKEKVARFSSSSPFQNLE-------------------------- ---------------------------IIATLGVGGFGRVEL---VKVKN--ENVAFAMK CIRKKHIVDTKQQEHVYSEKKILEELCSPFIVKLYR--------TFKDNKYVYMLLEACL GGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVD FGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGID QMMTYNLILKGIEKMDFP-RKITRRPEDLIRRLC-RQNPTERLGNLKNGINDIKKHRWLN GFNWEGLKARNLPSPLQRELSGPTDHSYFDKYPP-------ERGV-PPDELSGWDKDF >T_nigroviridis_ENSTNIP00000011460 MGTLRD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LQYALQEKIEELRQRDALIDEL--------------ELELDQKDE-- -------LIQ----RLQNE-------LDKYRSVIKPATQ--------------------- --------------------------------QVHKQT--ELQ----------------- -----------------------EHQ-RTKR-QA--ISAEPTA--FD-IQDL--SHVTL- ------------------------------PFYPKSPQSKDLIKEAILDNDFMKNL-ELS Q-IQEIVDCMYPVEYG----KDSCIIKEG--DVGSLVY--VM-E--DGKVEVTK-ES--- ---LKLCTMGPGKVFGELAILYNCTRTATV--KTLTN-VKLWAIDRQCFQTIMM--RTGL IKHTEYMEFL--KS-VPTF-QGLQEDILSKLADVLEETHYEDGEYIIRQGARGDTFFIIS KGKVNVTREDSP------NGEPVYLRSLGKGDWF-G-E-KALQGEDIRTANVIAAE--AV TCLVIDRDSFKHLIGGLEDVS--------SKGHEDA--------DAKAKRDR-------- -----------------YEAENAFFFNLNLADFN-------------------------- ---------------------------IINTLGVGGFGRVEL---VQLKSD-ENKTFAMK ILKKRHIVDTRQQEHIRSEKLIMQEAHSDFIVRLYR--------TFKDSKYLYMLMEACL GGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVD FGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMFELLTGSPPFSGPD PMKTYNIILRGIDMIEFP-KKITKNAANLIKKLC-RDNPSERLGNLKNGVKDIQKHKWFE GFNWEGLKKGTLTPPIIPNVTSAIDTSNFDSFPE-------DNEDPPLDDNSGWDVDF >H_sapiens_ENSP00000363092 MGTLRD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LQYALQEKIEELRQRDALIDEL--------------ELELDQKDE-- -------LIQ----KLQNE-------LDKYRSVIRPATQ--------------------- --------------------------------QAQKQSASTLQ----------------- -----------------------GEP-RTKR-QA--ISAEPTA--FD-IQDL--SHVTL- ------------------------------PFYPKSPQSKDLIKEAILDNDFMKNL-ELS Q-IQEIVDCMYPVEYG----KDSCIIKEG--DVGSLVY--VM-E--DGKVEVTK-EG--- ---VKLCTMGPGKVFGELAILYNCTRTATV--KTLVN-VKLWAIDRQCFQTIMM--RTGL IKHTEYMEFL--KS-VPTF-QSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIIS KGTVNVTREDSP------SEDPVFLRTLGKGDWF-G-E-KALQGEDVRTANVIAAE--AV TCLVIDRDSFKHLIGGLDDVS--------NKAYEDA--------EAKAK----------- -----------------YEAEAAFFANLKLSDFN-------------------------- ---------------------------IIDTLGVGGFGRVEL---VQLKSE-ESKTFAMK ILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYR--------TFKDSKYLYMLMEACL GGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVD FGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPD PMKTYNIILRGIDMIEFP-KKIAKNAANLIKKLC-RDNPSERLGNLKNGVKDIQKHKWFE GFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPE-------DNDEPPPDDNSGWDIDF >M_mulatta_ENSMMUP00000014212 MGTLRD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LQYALQEKIEELRQRDALIDEL--------------ELELDQKDE-- -------LIQ----KLQNE-------LDKYRSVIRPATQ--------------------- --------------------------------QAQKQSASTLQ----------------- -----------------------GEP-RTKR-QA--ISAEPTA--FD-IQDL--SHVTL- ------------------------------PFYPKSPQSKDLIKEAILDNDFMKNL-ELS Q-IQEIVDCMYPVEYG----KDSCIIKEG--DVGSLVY--VM-E--DGKVEVTK-EG--- ---VKLCTMGPGKVFGELAILYNCTRTATV--KTLVN-VKLWAIDRQCFQTIMM--RTGL IKHTEYMEFL--KS-VPTF-QSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIIS KGTVNVTREDSP------SEDPVFLRTLGKGDWF-G-E-KALQGEDVRTANVIAAE--AV TCLVIDRDSFKHLIGGLDDVS--------NKAYEDA--------EAKAK----------- -----------------YEAEAAFFANLKLSDFN-------------------------- ---------------------------IIDTLGVGGFGRVEL---VQLKSE-ESKTFAMK ILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYR--------TFKDSKYLYMLMEACL GGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVD FGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPD PMKTYNIILRGIDMIEFP-KKIAKNAANLIKKLC--DNPSERLGNLKNGVKDIQKHKWFE GFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPE-------DNDEPPPDDNSGWDIDF >P_troglodytes_ENSPTRP00000004326 MGTLRD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LQYALQEKIEELRQRDALIDEL--------------ELELDQKDE-- -------LIQ----KLQNE-------LDKYRSVIRPATQ--------------------- --------------------------------QAQKQSASTLQ----------------- -----------------------GEP-RTKR-QA--ISAEPTA--FD-IQDL--SHVTL- ------------------------------PFYPKSPQSKDLIKEAILDNDFMKNL-ELS Q-IQEIVDCMYPVEYG----KDSCIIKEG--DVGSLVY--VM-E--DGKVEVTK-EG--- ---VKLCTMGPGKVFGELAILYNCTRTATV--KTLVN-VKLWAIDRQCFQTIMM--RTGL IKHTEYMEFL--KS-VPTF-QSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIIS KGTVNVTREDSP------SEDPVFLRTLGKGDWF-G-E-KALQGEDVRTANVIAAE--AV TCLVIDRDSFKHLIGGLDDVS--------NKAYEDA--------EAKAK----------- -----------------YEAEAAFFANLKLSDFN-------------------------- ---------------------------IIDTLGVGGFGRVEL---VQLKSE-ESKTFAMK ILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYR--------TFKDSKYLYMLMEACL GGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVD FGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPD PMKTYNIILRGIDMIEFP-KKIAKNAANLIKKLC-RDNPSERLGNLKNGVKDIQKHKWFE GFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPE-------DNDEPPPDDNSGWDIDF >D_melanogaster_FBpp0088350 MRFCFDRLCFATKRPAQNSNSNAPHSSTTVDAPPRPADVDVATVPVATPAPPPQQPVSNL FYADYQKLQPAIIDRDWERDRDTDTDTRSEAKPPDIVEHIEPVEEQRQIHTQIQSPAEIQ IQIPPTPPAPSIQIQIQQRYRRHSSAED-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------RNLNTRRNDSNITEALRKAASMQQEPNANYQFPTDLGLVSIV NNNNNTNTHPSGSNSGSNNNSNINNNLVGGIVTLPAAGGLIGLEHTASGLRLIPAPPTHS DVLTHTLIYGTPPSGAQQLNQDPRSLLHQQELQLQQRYQQLQQLQAQTQGLYTSQGSPVL YHQPSPGSSQPVAIPGATCHSPTQLQPPNTLNLQQQMQSLRISGCTPSGTGGSATPSPVG LVDPNFIVSNYVAASPQEERFIQIIQAKELKIQEM--------------QRALQFKDN-- -------EIA----ELKSH-------LDKFQSVFPFSRG-SAAGCAGTGGASGS------ ----------------------GAGGSGGSGPGTATGATRKSGQ---------------- -----------------------NFQ-RQRA-LG--ISAEPQS--ES-SLLL--EHVSF- ------------------------------PKYDKDERSRELIKAAILDNDFMKNL-DLT Q-IREIVDCMYPVKYP----AKNLIIKEG--DVGSIVY--VM-E--DGRVEVSR-EG--- ---KYLSTLSGAKVLGELAILYNCQRTATI--TAITE-CNLWAIERQCFQTIMM--RTGL IRQAEYSDFL--KS-VPIF-KDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIIS KGKVRVTIKQQD------TQEEKFIRMLGKGDFF-G-E-KALQGDDLRTANIICESADGV SCLVIDRETFNQLISNLDEIK--------HRYDDEG--------AME------------- -----------------RRKINEEFRDINLTDLR-------------------------- ---------------------------VIATLGVGGFGRVEL---VQTNGD-SSRSFALK QMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFK--------TFKDKKYLYMLMESCL GGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVD FGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSD PMRTYNIILKGIDAIEFP-RNITRNASNLIKKLC-RDNPAERLGYQRGGISEIQKHKWFD GFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPP-------DPEGPPPDDVTGWDKDF >G_gallus_ENSGALP00000006027 LGTLRD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LQYALQEKIEELRQRDALIDEL--------------ELELDQKDD-- -------LIP----KLQNK-------L-VYRSVIRPAAR--------------------- --------------------------------QAQQQSARSLQ----------------- -----------------------GEQ-RTKR-QA--ISAEPTA--FD-IQDL--SHVTL- ------------------------------PFYPKSPQSKELIKEAILDNDFMKNL-ELS Q-IQEIVDCMYPVEYG----KDSCIIKEG--DVGSLVY--VM-E--DGKVEVTK-EG--- ---VKLCTMGPGKVFGELAILYNCTRTATV--KTLVN-VKLWAIDRQCFQTIMM--RTGL IKHTEYMEFL--KS-VPTF-QSLPEEILSKLADVLEETHYESGEYIIRQGARGDTFFIIS KGKVNVTREDSP------SEDPVFLRTLGKGDWF-G-E-KALQWEDVRTANVIAAE--AV TCLVIDRDSFKHLIGGLDDVS--------NKAYEDA--------EAKAK----------- -----------------YEAEAAFFANLKLSDFN-------------------------- ---------------------------IIDTLGVGGFGRVEL---VQLKSE-ETKTFAMK ILKKRHIVDTRQQEHIRSEKQIMQSAHSDFIVRLYR--------TFKDSKYLYMLMEACL GGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVD FGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPD PMKTYNIILRGIDMIEFP-KKIAKNAANLIKKLC-RDNPSERLGNLKNGVKDIQKHKWFE GFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPE-------DNDEPPPDDNSGWDIDF >M_domestica_ENSMODP00000025995 MGN--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G SVKPKQSKIPDG--------------HAGKLSGT-------IDALRSKVTE--------- -------------LERELKKKDDELQQREYHLREL--------------QEKLSKQTI-- -------ALA----EITEELQNKCIQLNKLQDVVNIQGG-NS--------LLFS------ ----------------PYK---------VPLQVNRRTSGLVSL----------------- -----------------------HSR-RGAK-EG--VSAEPTTRTF------AEFSFEK- ------------------------------ARVRKDSSDKKLITDALNKNQFLKRL-DPQ Q-IKDMVECMYGRNYP----QGSYIIKQG--EPGNHIF--VL-A--EGRLEVFQ-GN--- ---KLLSSIPMWTTFGELAILYNCTRTASV--KAISN-VKTWALDREVFQNIMR--RTAQ ARDEQYRQFL--RS-VCLL-KNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILA KGVVKVTQSTEG------YDQPQLIKTLKKGDYF-G-E-KALISDDVRSANIIAEEN-DV ACLVIDRETFSQTVGTFEELQKYLEGYVANLNRDDE--------KRHAKRSMSGWRQT-- -------KALSLEMIQLKEKVAKFSSSSPFQNLE-------------------------- ---------------------------IVTTLGVGGFGRVEL---VKVKN--ENVAFAMK CIRKKHIVDTKQQEHIYSEKKILEEMCSPFIVKFYR--------TFKDRKYVYMLLEACL GGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVD FGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGID QMMTYNLILKGIEKIDFP-KKITRRPEDLIRRLC-RQNPTERLGNLKNGINDIKRHRWLN GFNWEGLKARSLPSPLKRELSGPIDHSYFDNYPP-------EKGI-PPDELSGWDKDF >O_latipes_ENSORLP00000007952 MGTLRD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LQYALQEKIEELRQRDALIDEL--------------ELELDQKDE-- -------LIQ----RLQNE-------LDKYRSVIKPATQ--------------------- --------------------------------QVHKQN--ELH----------------- -----------------------EQQ-RTKR-QA--ISAEPTA--FD-IQDL--SHVTL- ------------------------------PFYPKSPQSKDLIKEAILDNDFMKNL-ELS Q-IQEIVDCMYPVEYG----KDSCIIKEG--DVGSLVY--VM-E--DGKVEVTK-EN--- ---LKLCTMGPGKVFGELAILYNCTRTATV--KTLTN-VKLWAIDRQCFQTIMM--RTGL IKHTEYMDFL--KS-VPTF-HDLQEDILSKLADVLEETHYAGGEYIIRQGARGDTFFIIS KGKVNVTREDLP------NGEPVYLRSLGKGDWF-G-E-KALQGEDIRTASVIAAE--AV TCLVIDRDSFKHLIGGLEDVS--------SKGHDDA--------DAKAK----------- -----------------YEAENAFFFSLNLADFN-------------------------- ---------------------------IIDTLGVGGFGRVEL---VQLKSD-ENKTFAMK ILKKRHIVDTRQQEHIRSEKLIMQEAHSDFIVRLYR--------TFKDSKYLYMLMEACL GGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVD FGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMFELLTGSPPFSGPD PMKTYNIILRGIDMIEFP-KKITKNAGNLIKKLC-RDNPCERLGNLKNGVKDIQKHKWFE GFNWEGLKKGTLTPPIIPNVTSPVDTSNFDSFPE-------DNEDPPPDDNSGWDVDF >T_rubripes_ENSTRUP00000026640 MSDL-D------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EDFAKILLLKEERIRD-----L--------------ERRLADRED-- -------EIQ----ELKRK-------LHKCQSVL-PSAQ--------------------- --------------------------------LI-------------------------- ------------------------GP-RTRRAQG--ISAEPQT--H---QDL--SRQTF- ------------------------------RKYAKSDWSKDLIKEAILDNDFMKNL-ELS Q-IQEIVDCMYPVEYG----KDSCIIKEG--DVGSLVY--VM-E--DGKVEVTK-ES--- ---LKLCTMGPGKVFGELAILYNCTRTATV--KTLTN-VKLWAIDRQCFQTIMM--RTGL IKQTEYMEFL--KS-VPTF-QGLQEDILSKLADVLEETHYEDGEYIIRQGARGDTFFIIS KGKVNVTREDSP------SGEPVYLRSLGKGDWF-G-E-KALQGEDIRTANVIAAE--AV TCLVIDRDSFKHLIGGLEEVS--------SKGHEDA--------DAKAK----------- -----------------YEAENAFFFNLNLADFN-------------------------- ---------------------------IIDTLGVGGFGRVEL---VQLKSD-ENKTFAMK ILKKRHIVDTRQQEHIRSEKLIMQEAHSDFIVRLYR--------TFKDSKYLYMLMEACL GGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVD FGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMFELLTGSPPFSGPD PMKTYNIILRGIDMIEFP-KKITKNAANLIKKLC-RDNPSERLGNLKNGVKDIQKHKWFE GFNWEGLKKGTLTPPIIPTVTSAVDISNFDNFPE-------DKEDPPPDDNSGWDVDF >T_nigroviridis_ENSTNIP00000019469 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------PET---------LEITR- ------------------------------ARVKKNSSEANLIVKAIQKNDFLSRL-DDE Q-TAMMVDLLAVSNFK----PGSHVIKEG--SEGDSMY--IV-A--GGQLQVTQ-AG--- ---RDLRTLTTGDVFGELAILYNCKRTATVTDSAKTA-VRLWCMERQTYRTIIT--NKSK KRREQLMGFL--KM-SQTL-KDLNNVQLSKIIDSMEEVKYQDKDVIVREGAEANTFYIIL KGEVLVTKNVNG--------HQKQIRRMGKGEHF-G-E-QALIREVLRTATCTADGP--V TCFTIDKEVFEETI----PVE--------HLE------------LFDDSKVLQEARAPAK SSKQFCLSTSPSSTLRFKDLVPVLYQEGRYQGDP-------------------------- -----------------------------VTLGVGGFGRVEL---MT-TVN-HGMYYAMK RVSKKHIVAKRQEEHMLFEKKILKAIQCDFIVRLHA--------TFKDTRYVYMIMEFCG GGEIWTKLKEVGRFDEPMAVFCAACVVEAFAYLHKKSIMYRDLKPENLMLDAKGYVKLVD FGFAKEMVRAEKTYSFVGTPEYMAPEIIKNQGHDFAVDFWSLGILIFELLAGSPPFSSSE PQKIYAKILDGV--LKYP-PYLSEASKSIISKLC-RPRPGQRLGNTKNGIKDVRHHRWFS SINWHKLRMSQLDAPTVRLIRKGPCYINFDRFPV-------DHTK-VEEEFSGWDQDF >T_rubripes_ENSTRUP00000032043 -EE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LKQQLEKQCLINKELQRQNKDL--------------EKRLQEKEK-- -------LLQ----NLQSQYHDLVFQISLLSPLMRLTPR--------------------- ------------------------------------------------------------ ---------------------------SGRA-VR--LSSPPSPSTRRWRLLAPGS----- ------------------------------RKIPALTSEANLIVKAIQKNDFLSRL-DDE Q-TAMMVELLAVSSFK----PGDHVIKEG--TEGDSMY--IV-A--GGELRVTQ-AG--- ---RDLRTLTTGDVFGELAILYNCKRTATV--TAKTA-VRLWCMERQTYRTIIT--NKSK KRREQLMGFL--KM-SRTL-KDLNDVQLSKIIDSMEEVKYQDKDVIVREGAEANTFYIIL KGEVLVTKNVNG--------HQKQIRRMGKGEHF-G-E-QALIREVLRTATCSADGP--V TCLSIDKERA--------HIS--------FCL------------FAPSSKVLQEAQAPPK ----------SSKEIVFEETIPVEHLEVF------------------------------- -----------------------------DELGVGGFGRVELHSKMT-TVN-HGMYYAMK RVSKKHIVAKRQEEHMLFEKKVLKAIQCDFIVRLHA--------TFKDTCYVYMIMEFCG GGEIWTKLKEVGRFDEPTAVFCTACVVEAFAYLHKKSVMYRDLKPENLMLDVKGYVKLVD FGFAKEMVRGEKTYSFVGTPEYMAPEIIKNQGHDFAVDFWSLGILIFELLAGSPPFSSSE PQKIYAKILDGV--LKYP-PYLSEASKSIISKLC-RPRPGQRLGNTKNGIKDVRHHRWFS SINWHKLRMSQLDAPTVRLIRKGPCYINFDRFPV-------DHTK-AEEDFSGWDREF >C_familiaris_ENSCAFP00000013072 MGN--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G SVKPKHPKHPDG--------------HPGNLS---------THALRSKVVE--------- -------------LERELRRKEAEIQEREYHLKEL--------------REQLSRQTA-- -------AVA----ELTEELQNKCIQLNKLQDVVHLQGG-SL--------PQAS------ ----------------PDK---------VPLEVHRKASGLVSL----------------- -----------------------HSR-RGAK-AG--VSAEPTSRTYD-LNKPPEFSFEK- ------------------------------ARVRKDSSEKKLITDALNKNQFLKRL-DPQ Q-IKDMVECMYGRNYQ----QGSYIIKQG--EPGNHIF--VL-AVIEGRLEVFQ-GE--- ---KLLSSIPLWTTFGELAILYNCTRTASV--KALTN-VKTWALDREVFQNIMR--RTAQ ARDEQYRNFL--RS-VSLL-KNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILA KGKVKVTQSTEG------HDQPQVIKTLQKGEYF-G-E-KALISEDVRSANIIAEEN-DV ACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDE--------KRHAKRSMSNWKLS-- -------KALSLEMIQLKEKVARFSSSSPFQNLE-------------------------- ---------------------------IIATLGVGGFGRVEL---VKVKN--ENVAFAMK CIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYR--------TFKDNKYVYMLLEACL GGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDADGYLKLVD FGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGID QMMTYNLILKGIEKMDFP-RKITRRPEDLIRRLC-RQNPTERLGNLKNGINDIKKHRWLN GFNWEGLKARNLPSPLQRELSGPTDHSYFDKYPP-------EKGV-PPDELSGWDKDF >G_aculeatus_ENSGACP00000013490 LEE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LKQQLQKQCMINQELQRQNKDL--------------EQRLQEKER-- -------LLQ----ELNGQYDELGVP-SQSGNVVEPEIR--------------------- ------------------------------------------------------------ ---------------------------KSRA-AV--IASEPLPETLEIR----------- ------------------------------KRVKKVASETSLIVKAIQKNDFLSRL-DDE Q-TAMMVDLLAVSSYK----PNDDVIKEG--TEGDSMY--IV-A--AGELLVTQ-AG--- ---QTLRSLTTGDVFGELAILYNCRRTATV--KAKTA-VRLWCMERQTYRTIIT--NKSK KKREQLLGFL--KT-SRTL-KELNDVQLSKIIDSMEEVKYQDKDVIVREGAEANAFYIIL KGEVLVTKNVNG--------HQKQIRRMGKGEHF-G-E-QALIREVLRTATCSAEGP--V TCLSIDKEVFEETI----PIE--------HLE------------LFDD------------ ----------PGSTLRFKDLVPVLYQEGRYQGDP-------------------------- -----------------------------VTLGVGGFGRVEL---VT-TVN-HEEYYAMK RVSKKHIVAKRQEEHMLFEKKILKATQCNFIVSLHA--------AFKDTRYIYMVMEFCV GGEIWTKLKEVGRFDEPIAMFCTACVVEAYAYLHKKNIMYRDLKPENLMLDIKGYVKLVD FGFSKEMVHGDKTYSFVGTPEYMAPEIIKNQGHDFAVDFWSLGVLIYELLVGSPPFSSSE PQKIYAKILDGV--LKYP-PYMSEAARSIISKMC-RPRPGQRLGNTKNGIRDVRNHRWFS SMNWHKLRVGQLDAPTVRLIRKGPCYINFDRFPL-------DQTK-AEEEFSGWDRDF >C_elegans_F55A8.2a.1 MSS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GSRPSSGGGGGGGGASG GAGGGAPGGGGGGIRGFFSKLRKPSDQPNGNQVQVGTRTFEAHELQKLIPQ--------- -------------LEEAISRKDAQLRQQQTIVEGH--------------IKRISELEG-- -------EVT----TLQRE-------CDKLRSVLEQKAQ-SAASPGGQP----------- --------------------PSPSPRTDQLGNDLQQKAVLPAD----------------- -----------------------GVQ-RAKK-IA--VSAEPTN------FEN--KPATL- ------------------------------QHYNKTVGAKQMIRDAVQKNDFLKQL-AKE Q-IIELVNCMYEMRAR----AGQWVIQEG--EPGDRLF--VV-A--EGELQVSR-EG--- ---ALLGKMRAGTVMGELAILYNCTRTASV--QALTD-VQLWVLDRSVFQMITQ--RLGM ERHSQLMNFL--TK-VSIF-QNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVIN SGQVKVTQQIEG------ETEPREIRVLNQGDFF-G-E-RALLGEEVRTANIIAQAP-GV EVLTLDRESFGKLIGDLESLK---------KDYGDK--------ERLAQVVREPPSPVKI -----------------VDDFREEFAQVTLKNVK-------------------------- ---------------------------RLATLGVGGFGRVEL---VCVNGD-KAKTFALK ALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYK--------TFRDQKFVYMLLEVCL GGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVD FGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASD PMKTYTLILKGVDALEIPNRRIGKTATALVKKLC-RDNPGERLGSGSGGVNDIRKHRWFM GFDWEGLRSRTLKPPILPKVSNPADVTNFDNYPP-------DNDV-PPDEFSGWDEGF >T_rubripes_ENSTRUP00000001539 MGN--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A SMKSKRYKNADGSVTASNSWSHRDGRRLKNAS---------LESLRVRVEE--------- -------------LEREGKRRNEELQAKEQQIRSL--------------QEQLARQTR-- -------VLA----ELSEELQTKCIQLSKLQDVMKSQGG-AG--------TASR------ ----------------PTS-----VRKAGKSSPNLSVRIKETL----------------- -----------------------NRR-KGAK-AG--VSAEPTS------SSLPKFCFEK- ------------------------------ARVAKDNSVKKLLTDALNKNQYLRRL-ELQ Q-IKDIVECMYERTYQ----RGEYVVKQG--EPGNHLF--VLAA--DGTLDVFQ-HN--- ---KLLTSITVWTTFGELAILYNCTRTASV--RAVND-VRTWALDREVFQNIMR--RTAE MRHEQYRNFL--RS-VSLL-ANLPEDKLSKMVDCLEVEYYDKGEFIIREGEEGSTFYIIA QGKVKVTQTTEA------HTFPQVINTLQKGDYF-G-E-KALVSDDVRSASILAEEN-GV ECLVIDRETFDQTVGTFSELQKHLQGYVATLDRDDR--------KRHARKKSVSRHQS-- -------QPLSSDAICLKEMVSTFSASRPFDHLE-------------------------- ---------------------------VVATLGVGGFGRVEL---VKMQD--KDVAFALK IIKKKHVVDNRQEEHIHSERKILAEARSPFIVKLYR--------TFKDNKYVYMLLEACL GGEVWSLLRDRGNFEEPTAKFCVGCVTEAFDYLHRKGILYRDLKPENLLLDAEGYIKLVD FGFAKKIRCGQKTWTFCGTPEYVAPEIILNKGHNFSVDFWSLGILVFELLTGSPPFSGSD QMMTYTFILKGIEKMDFP-KKITKRPEDLIRKLC-RQNPAERLGNLKNGITDIKKHRWFN GFSWEGLKAKTLPSPLKRALTGPTDHSYFDSYPP-------DEDS-PPDELSGWDVDF >O_latipes_ENSORLP00000021688 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------LIIKAIQKNDFLSRL-DEE Q-IAMMVDLLRASNFK----PGEEVIIEG--CEGDSMY--IV-A--AGELIVTQ-AG--- ---QDLRTLSIGDVFGELAILYNCKRTATV--KAKTQ-VRLWCMERQTYRTIIT--NKSK KRRGQLMGFL--KT-SRTL-KNLNDVQLSKIIDSMEEVKYQDKEVIVREGAEANSFYIIL KGEVLVTKNVNG--------YQKQIRRMGKGEHF-G-E-QALIREVLRTATCTADGP--V TCLSIDKDSF--------CVL--------LLL------------TPADSKVMQEAETPAK S--------LPSSTLRFKDLVPVLYQEGRFQGDP-------------------------- -----------------------------VTLGVGGFGRVEL---VNLAFH-HGKYYAMK RVSKKQIVAKRQEEHMLFEKKILKAIQCDFIVRLYS--------TFKDTRYIYMVMDFCS GGEIWTKLKEVGRFDEPIAVFCTACVVEAYAYLHKKNIMYRDLKPENLMLDQRGYIKLVD FGFAKELMRGDKTYSFVGTPEYMAPEIIKNQGHDFAVDFWSLGILIFELLAGSPPFSSSE PQKIYAKILDGE--LKYP-PYMNEAAKSIISKLC-RPRPGQRLGNTKNGIKEVRHHRWFG NMNWHKLRLGQLEAPTVRLIRKGPCYINFDRFPV-------DHTK-ADEDFSGWDRDF >O_cuniculus_ENSOCUP00000007323 MGN--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G SVKPKHSKHPDG--------------HSGNLT---------TDALRNKVAE--------- -------------LERELRRRDAEIQEREYHLKEL--------------REQLSKQTV-- -------AIA----ELTEELQNKCIQLNKLQDVVHVQGG-SL--------PQAS------ ----------------PDK---------VLLEVHRKTSGLVSL----------------- -----------------------HSR-RGAK-AG--VSAEP-TRTYD-LNK--LVSFEK- ------------------------------A---KDSSEKKLITDALNKNQFLKRL-DPQ Q-IKDMVECMYGRNYQ----QGSYIIKQG--EPGNHIF--VL-A--EGRLEVFQ-GE--- ---KLLSSIPMWTTFGELAILYNCTRTASV--KAITN-VKTWALDREVFQNIMR--RTAQ ARDEQYRNFL--RS-VSLL-KNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILA KGKVKVTQSTEG------HDQPQLIKTLQKGEYF-G-AFTRLISDDVRSANIIAEEN-DV ACLVIDRETFNQTVGTFEDLQKYLEGYVANLNRDDE--------KRHAKRSMSSWKLS-- -------KALSLEMIQLKEKVARFSSSSPFQNLE-------------------------- ---------------------------IIATLGVGGFGRVEL---VKVKN--ENVAFAMK CIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYR--------TFKDNKYVYMLLEACL GGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDADGYLKLVD FGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGID QMMTYNLILKGIEKMDFP-RKITRRPEDLIRRLC-RQNPTERLGNLKNGINDIKKHXXXX XXXXXXXXXXXXXXXXXXXLSGPIDHSYFDKYPP-------EKGV-PPDELSGWDKDF >A_aegypti_AAEL013214-PA M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------HLIDRLVPGSYIVAHWFDPVRLSRRIYEQEFNPIANGTSRTVGK FSPKGTERESGLGSLDERLNLPNGTPWEARPVSVPQPQFERKTPLPTVKDRISASSQEPD RNVNFELLKEIQQTKILLQLALESKLREHPNNDDRHQLVKLEKEIKELQNRISKSTIVPE PVQESVIVRQNAHPTARASPQPSHGPPRPNLPPPKSSLSRQISTIPTQAWEASETSD--- --DYDTIPPSKSKVQSVPEVTSSEEEDEDEEIPDT--------------QDDTSQDEEPT PPKLPPPRVP----SMVDDMISLSVPLSMVSNEIEKAQQ-APPVPSGPP----------- ----------------PKRMPPPTPEKEVTLGTPTQRDSEDSLPPPKIEELNSSR----- --------------------TAGILK-KVRK-EG--VLSDKTE-----VKGS--REIVI- ------------------------------PSHPKRTDDELLIRKAITANEFLNNLMDEE R-LKAVTDAMSPMTFP----PNSYIIKEG--DIGAHFF--VS-A--DGTYEVVA-EN--- ---KVIKSFGRGVVFGELAILYKAKRFASI--RVTTE-AKVWMLERKVFQKIMM--KSGR KEREENVKFL--ST-VSIL-KDLQTEKLHKISDLLKREFYATGSTIIQQGDPGDKFYIIR GGSVNVIKT-DR------HGVDKLVGTLQRGAYF-G-E-QALLHEDRRLASIIANPP-GT ECLTLNRIAFNEFLGGLEQLR--------EIKLSDD--------LPRISG---------- -----------------DKNTSSEYDHIQLHDLT-------------------------- ---------------------------YIGTLGIGGFGRVEL---VRYQ---KQKTFALK YLKKIEMVRQQQQEHAYSEKDIMLSCNSPFIVRLYK--------TYRDKKYLYFLMEACL GGDVWTILQKSKHFDERTARFMAGCVVEAFEYLHSRNMIYRDLKPENLMLDEQGYIKLVD FGFAKRIGANQKTWTFAGTPEYVSPEIILNKGHDRAVDYWALGVFIHELLVGKPPFRGKN HMKTYNAILRGIDIIELP-SRIPKKAQVLIKRLC-RQIPAERLGYGKNGIADIKNHPWFS GFEWQRLKERTLPAPLVRPIQSDTDLSNFDEYPK-------DQDE-PPDETSGWDINF >D_rerio_ENSDARP00000092292 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------IVKAIGKNDFLRRL-DEE Q-ISMMVDLMKVLDCR----AGDEIIKEG--TEGDSMY--IV-A--AGELKVTQ-AG--- ---RDLRILSPGDMFGELAILYNCKRTASV--KAISA-VKLWCIERQTYRSIMT--NKSK MKREQLMGFL--KT-ARTL-KALNDVQLSKIIDSMEEVRFQDNEVIVREGAEGNTFYIIL KGEVLVTKKVNG--------QQKTIRKMGEGEHF-G-E-LALIREILRTATCTAVGV--V ICFSIDKDHYTSGVEGLLEIR--------HTESSCQ--------AQVQVHVIYDAKNSAS ---------HSQNKLHFK------------IGDP-------------------------- -----------------------------VTLGIGGFGKVEL---VT-TLE-HRKYFAMK RISKQHVVAKKQEAHILLEKKILQAIRCDFIVRLHA--------AFKDSRYVYMIMEFCP GGEIWTKLKEAGRFEEKIAVFITACVVEAYAYLHNKGILYRDLKPENLMLDSKGYVKLVD FGFAKELSRGEKTYSFCGTPEYISPEIIQNQGHDIAADFWSLGVLIYELLVGSPPFSSSE PQKIYAKILDGV--LNFP-SYMGEGAKSIISKLC-RLRPGQRLGNTKNGIKDVRHHRWFN SINWHKLRMGQLEAPTVRLIRKGPCYINFDRFPY-------DKTQ-AEEEFSGWDCDF >G_gorilla_ENSGGOP00000007258 MGTLRD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LQYALQEKIEELRQRDALIDEL--------------ELELDQKDE-- -------LIQ----KLQNE-------LDKYRSVIRPATQ--------------------- --------------------------------QAQKQSASTLQ----------------- -----------------------GEP-RTKR-QA--ISAEPTA--FD-IQDL--SHVTL- ------------------------------PFYPKSPQSKDLIKEAILDNDFMKNL-ELS Q-IQEIVDCMYPVEYG----KDSCIIKEG--DVGSLVY--VM-E--DGKVEVTK-EG--- ---VKLCTMGPGKVFGELAILYNCTRTATV--KTLVN-VKLWAIDRQCFQTIMM--RTGL IKHTEYMEFL--KS-VPTF-QSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIIS KGTVNVTREDSP------SEDPVFLRTLGKGDWF-G-E-KALQGEDVRTANVIAAE--AV TCLVIDRXXXXXXXXXXXXXX--------XXXXXXX--------XXXXX----------- -----------------XXXXXXXXXXXXXXXXX-------------------------- ---------------------------XXXXXXXXXXXXXXX---VQLKSE-ESKTFAMK ILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYR--------TFKDSKYLYMLMEACL GGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVD FGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPD PMKTYNIILRGIDMIEFP-KKIAKNAANLIKKLC-XXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXVASPTDTSNFDSFPE-------DNDEPPPDDNSGWDIDF >A_aegypti_AAEL007826-PA MSSPKP------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --AMAGGSKNGTSSHSGGRNNGKLQSDSGNGRSIEDTVLSLRRELREVYETLREKNEQLV QLEKDVRDRDISIRYLKNEFKKLKDYYSCSKSDLSIPPSFNLNGNGKSAGDGGS------ -------------LEDLLQKVQKECKEKDLQIRELNQKVIRLSNNLIYVQKESLSKDD-- -------RID----ELQNE-------IDKFRQVVRPITK-AM------------------ -----------------IEKRCSEETYDSFSPGIENTRVLPVN----------------- -----------------------HEP-RMKR-QA--ISAEPLS-----SLAG--MQGDL- ------------------------------IKIPKSSLSREIIKSAILDNDFMKNL-EMT Q-IREIVDCMYPVQYG----AGSLIIKEG--DVGSIVY--VM-E--EGRVEVSR-EG--- ---KYLSTLSGAKVLGELAILYHCQRTATI--TAATD-CKLWAVERQCFQTIMM--RTGL IRQAEYSDFL--KS-VPIF-KNLPEDTLGKISDVLEECYYQKGDYIIRQGARGDTFFIIS KGQVRVTIRQPD------TQEEKFIRTLGKGDFF-G-E-KALQGDDLRTANIICDSPEGV TCLVIDRDTFNQLISNLDEIK--------NRYNDDA--------VSE------------- -----------------KKKIYEEFRDVRLTDLR-------------------------- ---------------------------VIATLGVGGFGRVEL---VQLAQD-KARSFALK QMKKSQIVETRQQQHIMSEKEIMSEANSDFIVKLFK--------TFKDRKYLYMLMESCL GGELWTILRDRGHFDDGTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLDVSGYVKLVD FGFAKKLQSGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGAD PMRTYNIILKGIDAIEFP-RNITRNASVLIKKLC-RDNPTERLGYQRGGISEIQKHKWFD GFYWEGLRNRSLPPPILPKVQSVVDTANFDDYPA-------DPDGPPPDDLSGWDEDF