10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000269305 --------------------------------------MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLP---------------------------------------------- P_troglodytes_ENSPTRP00000014836 --------------------------------------MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLP---------------------------------------------- G_gorilla_ENSGGOP00000009561 --------------------------------------MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLP---------------------------------------------- P_pygmaeus_ENSPPYP00000008923 --------------------------------------MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLP---------------------------------------------- M_mulatta_ENSMMUP00000035274 --------------------------------------MEEPQSDPSIEPPLSQETFSDLWKLLPENNVLSPLP---------------------------------------------- O_cuniculus_ENSOCUP00000000989 --------------------------------------MEESQSDLSLEPPLSQETFSDLWKLLPENNLLTTSL---------------------------------------------- C_familiaris_ENSCAFP00000024579 ------------------------------------AAMQEPQSELNIDPPLSQETFSELWNLLPENNVLSSEL---------------------------------------------- M_musculus_ENSMUSP00000104298 -----------------------------------MTAMEESQSDISLELPLSQETFSGLWKLLPPEDILPS------------------------------------------------ B_taurus_ENSBTAP00000001420 --------------------------------------MEESQAELNVEPPLSQETFSDLWNLLPENNLLSSEL---------------------------------------------- R_norvegicus_ENSRNOP00000047840 --------------------------------------MEDSQSDMSIELPLSQETFSCLWKLLPPDDILPTTATG-------------------------------------------- E_caballus_ENSECAP00000006210 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000051548 ------------------------------------------------MAQNDSQEFAELWEKNLISIQ--------------------------------------------------- X_tropicalis_ENSXETP00000053761 ---------------------------------------MEPSSETGMEPPLSQETFEDLWSLLPDPLQTGTGQ---------------------------------------------- G_aculeatus_ENSGACP00000018012 --------------------------------------------------------------------------------------------------------------------MLYL T_nigroviridis_ENSTNIP00000013035 ------------------------------------------MEEETFSLPLSQDTFQDLWENVAAPSISTIQ----------------------------------------------- A_carolinensis_ENSACAP00000001746 --------------------------------------VKMSRS----SPADEGTTFEHLWSTLEPDSTYFDLPQSGPRTGSETP-----------------------NRTEVTMDVFQ- T_rubripes_ENSTRUP00000008025 -NFDARRVADMMVAVLPLVCRLRDPASRLSWRDSSFLTTMSHNQSSQTSDSFSQDVFNQLFDMLDQSAIHSVQPIELNFTDSPRD-------------------GSAGNTIQISMDCITM X_tropicalis_ENSXETP00000010981 --------------------------------------LKMSQS----SGADEGTTFEHLWSTLEPDSTYFELPQSSHSNNTEAS-----------------------NRTDVNMDVYQ- T_nigroviridis_ENSTNIP00000016776 ------------------VRSLRDSTSRLSWRDSSFLTAMSHNQSSQTSDSFSQDVFNQLFDMLDQSAIHSVQPIELNFTDSLRD-------------------GSAGNTIQISMDCITM C_familiaris_ENSCAFP00000028819 --------------------------------------MSQS------TANDEGATFEHLWSSLEPDSTYFDLPQPN-QGNSEVV-----------------------GGAEAGMDVFH- H_sapiens_ENSP00000367545 --------------------------------------MAQSTA----TSPDGGTTFEHLWSSLEPDSTYFDLPQSS-RGNNEVV-----------------------GGTDSSMDVFH- C_familiaris_ENSCAFP00000020585 LNIQYCKYGNYNSSFIFILLRFVETPAHFSWKESYYRSTMS--QSTQTNEFLSPEVFQHIWDFLEQ-PICSVQPIDLNFADEPSE-------------------NGARNKIEISMDCIRM T_rubripes_ENSTRUP00000030645 ------------------------------------------MEDEGFSLPLSQDTFQDLWENV-------------------------------------------------------- B_taurus_ENSBTAP00000007643 --------------------------------------------------------------TLQPDCVS---PPPS------------------------------------------- O_latipes_ENSORLP00000019616 ------------------LRRLRDPTSRLSWRDSSFLTAMAQNQSAQ-SDFSSQDVFNQLFDMLDQSAIHSVQPIELNFTDSPTD-------------------GSTGNTIQISMDCITM M_mulatta_ENSMMUP00000021768 --------------------------------------MAQSTT----TSPDGGTTFEHLWSSLEPDSTYFDLPQSS-RGNNEVV-----------------------GGTDSSMDVFH- M_musculus_ENSMUSP00000101269 --------------------------------------MSGSVGEMAQTSSSSSSTFEHLWSSLEPDSTYFDLPQPS-QGTSEAS-----------------------GSEESNMDVFH- R_norvegicus_ENSRNOP00000052265 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000001485 --------------------------------------VKMSQS----SPADESTTFEHLWSTLAPDSTYFDLSPSSHTGSNEVS-----------------------NRTEVTMDVFQ- G_aculeatus_ENSGACP00000008676 --------------------------------------MSQS------TVSEEGGTFEHLWSSLEPDSTYYELPPGSQGAERPVPSAGT--------------LGIHRSAAEASMDVYQ- O_anatinus_ENSOANP00000021753 --LKYSEQRCWMLKFPLIHCRFVETPAHFSWKESYYHSTMS--QSSQTSEFLSPEVFQHIWDFLEQ-PICSVQPIDLNFLDEPSE-------------------NGTTNKIEISMDCIRM M_mulatta_ENSMMUP00000021634 MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMS--QSTQTNEFLSPEVFQHIWDFLEQ-PICSVQPIDLNFVDEPSE-------------------DGATNKIEISMDCIRM P_pygmaeus_ENSPPYP00000016106 MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMS--QSTQTNEFLSPEVFQHIWDFLEQ-PICSVQPIDLNFVDEPSE-------------------GGATNKIEISMDCIRM D_rerio_ENSDARP00000074096 --------------------------------------MSQS------STADEGPTFEHLWSTLEPDSTYFELPQAGHSGDRASS-------------------SLPGNRAEVCMDVYHM H_sapiens_ENSP00000264731 MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMS--QSTQTNEFLSPEVFQHIWDFLEQ-PICSVQPIDLNFVDEPSE-------------------DGATNKIEISMDCIRM P_troglodytes_ENSPTRP00000027067 MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMS--QSTQTNEFLSPEVFQHIWDFLEQ-PICSVQPIDLNFVDEPSE-------------------DGATNKIEISMDCIRM R_norvegicus_ENSRNOP00000033463 MNFETSRCATLQYCPDPYIQRFIETPSHFSWKESYYRSAMS--QSTQTSEFLSPEVFQHIWDFLEQ-PICSVQPIDLNFVDEPSE-------------------NGATNKIEISMDCIRM M_musculus_ENSMUSP00000110965 MNFETSRCATLQYCPDPYIQRFIETPAHFSWKESYYRSAMS--QSTQTSEFLSPEVFQHIWDFLEQ-PICSVQPIELNFVDEPSE-------------------NGATNKIEISMDCIRM O_cuniculus_ENSOCUP00000014157 MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSAMS--QNSQPSEFLSPEVFQHIWDFLEQ-PICSVQPIDLNFVDEPSE-------------------NGATNKIEISMDCIRM E_caballus_ENSECAP00000016315 ---------------------------------------MS--QSTQTSEFLSPEVFQHIWDFLEQ-PICSVQPIDLNFVDEPSE-------------------NGATNKIEISMDCIRM T_rubripes_ENSTRUP00000038165 --------------------------------------MSQS------TVTEEGGTFEHLWSSLEPDSTYYELPPGSQQGERPVPSTST--------------PGCHCSAAESSMDVYH- M_domestica_ENSMODP00000018831 MNVDPSPYPTLPCCPEPFIQRFVDTPAHFSWKESYYRSTMS--QSSQTSEFLSPGVFQHIWDFLDQ-PICSVQPIDLNFMDEPTA-------------------NGTTNKIEISMNCIRM G_aculeatus_ENSGACP00000025614 ----------------------------------MMEGTGFEGLALGQDLPDSQDSFAELWGNVVSPPLLN------------------------------------------------- T_guttata_ENSTGUP00000002829 --------------------------------------VKMSQS----SPADEGPTFEHLWSTLEPDSTYFDLPPANPSGSNEVS-----------------------DRTEVTMDVFQ- G_gallus_ENSGALP00000011836 --------------------RFVETPSHFSWKESYYRSAMS--QSSQPREFLSPEVIQHIWDFLEQ-PICSVQPIDLNFIDDPSE-------------------NGPTNKIEISMDCVRL T_guttata_ENSTGUP00000009686 MNFEAAPFTTLPYYPDPCIQRFVETPSPFSWKESYYRSAMS--QSSQPREFLSPEVIQHIWDFLEQ-PICSVQPIDLNFIDGPSE-------------------DGSTNKIEISMDCVRV D_rerio_ENSDARP00000065136 --------------------------------------------------------------------------------------------------------------------MLYL T_nigroviridis_ENSTNIP00000014938 ---------------------------------------VQS------TVTEEGGTFEHLWSSLEPDSTYYELPPGSQQGERPLASTST--------------PGCHCSAAESSMDVYH- O_latipes_ENSORLP00000005521 ----------------------------------------------------------------EPDSTYFELPPNSRPGEHPVASTSI--------------SGSHCNSAEVSMDVYH- O_latipes_ENSORLP00000008029 ----------------------------------------WESMDPVPDLPESQGSFQELWETVYPPLETLSLPTVNEPTG--------------------------------------- E_caballus_ENSECAP00000001313 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000020544 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000015180 --------------------------------------MAQSTA----TSPDGGTTFEHLWSSLEPDSTYFDLPQSS-RGNNEVV-----------------------GGTDSSMDVFH- G_gorilla_ENSGGOP00000005012 MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMS--QSTQTNEFLSPEVFQHIWDFLEQ-PICSVQPIDLNFVDEPSE-------------------DGATNKIEISMDCIRM C_intestinalis_ENSCINP00000003956 -------------------------------------------MDRPPEGSFDPDCFSDIWNNQLSQQSEITSSQQIYTFNENTDGLTNSLTIDLLTEFQQFEQGPTSDANAGENQAGNT C_intestinalis_ENSCINP00000004447 ---------------------------------------MAVADTSELNFPDSQESFSDFWMNTLSENNELPSWQT--------------------------DLNQEYDQCKETVDVLQL P_pygmaeus_ENSPPYP00000002277 --------------------------------------MAQSTA----TSPDGGTTFEHLWSSLEPDSTYFDLPQSS-RGNNEVV-----------------------GGTDSSMDVFH- A_carolinensis_ENSACAP00000000376 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008216 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000019815 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000000118 --------------------------------------MAQSTA----TSPDGGTTFEHLWSSLEPDSTYFDLPQSS-RGNNEVV-----------------------GGTDSSMDVFH- A_aegypti_AAEL007594-PA ----------------------MSLLKRPPHETERTNNNLRNRNREEIEHHQKKGGTQHSCFVTVRKTLEMVDSQD----------------------------TNQTYGQPTQHPVDEC A_aegypti_AAEL007595-PA ---------------------------------------MVDSQDLKIESYNEEAEVASDEEMFPLTGNSVSGSAF-----------------------------PMGIDFVTSNGTFVI A_gambiae_AGAP002352-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0083753 ----------------------MSLHKSASFSLTFNQNTSIVSRSNSRTIFEAFKEFLDFWDIGNEVSAESAVRVS-----------------------------SNGAFNLPQSFGNES A_gambiae_AGAP004319-PA ----------------------------------------------------------------------------------------------------------MSYSPAPDDDAIIA 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000269305 ---SQAMDDLMLSPDDIEQWFTEDPGPDEAP-----------------------------------------RMPEAAPPVAPAPAAPTPAAPA-----------------PAPSWP--- P_troglodytes_ENSPTRP00000014836 ---SQAMDDLMLSPDDIEQWFTEDPGPDEAP-----------------------------------------RMPEAAPPVAPAPAAPTPAAPA-----------------PAPSWP--- G_gorilla_ENSGGOP00000009561 ---SQAMDDLMLSPDDIEQWFTEDPGPDEAP-----------------------------------------RMPEAAPPVAPAPAAPTPAAPA-----------------PAPSWP--- P_pygmaeus_ENSPPYP00000008923 ---SQAVDDLLLSPDDIAQWFIEDPGPDEAP-----------------------------------------RMSEAASPVGPAPAAPIPAAPA-----------------PAPSWP--- M_mulatta_ENSMMUP00000035274 ---SQAVDDLMLSPDDLAQWLTEDPGPDEAP-----------------------------------------RMSEAAPPMAPTPAAPTPAAPA-----------------PAPSWP--- O_cuniculus_ENSOCUP00000000989 ---NPPVDDL-LSAEDVANWLNED--PEEGL-----------------------------------------RVPAAPAPEAPAPAAPALAAPA-----------------PATSWP--- C_familiaris_ENSCAFP00000024579 ---CPAVDEL-LLPESVVNWLDED--SDDAP-----------------------------------------RM----------PATSAPTAPG-----------------PAPSWP--- M_musculus_ENSMUSP00000104298 ---PHCMDDL-LLPQDVEEFF-EG--PSEAL-----------------------------------------RVSGAPAAQDPVTETPGPVAPA-----------------PATPWP--- B_taurus_ENSBTAP00000001420 ---SAPVDDL-LPYTDVATWLDEC--PNEAP-----------------------------------------QMPEPS-----APAAPPPATPA-----------------PATSWP--- R_norvegicus_ENSRNOP00000047840 --SPNSMEDL-FLPQDVAELL-EG--PEEAL-----------------------------------------QVS-APAAQEPGTEAPAPVAPA-----------------SATPWP--- E_caballus_ENSECAP00000006210 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000051548 ---PPGGGSCWDIINDEEYLP---------------------------------------------------GSFDPNFFENVLEEQPQPS-----------------------TLP--- X_tropicalis_ENSXETP00000053761 ------------MENFAEFSE---------------------------------------------------YPLAPDMTVLQEGLMG-----------------------NTVPTV--- G_aculeatus_ENSGACP00000018012 ETGPSTTSYSESQYTNLGLLNSMDQ--SIQNGGSTST-----------------------------------SPYNNDHAQNS-VTAPSPYAQPSS---------------TFDALS--- T_nigroviridis_ENSTNIP00000013035 --TTVSGNECWQDGSLTMALMD--------------------------------------------------MPYDEDLFNLPSELPNKDG-----------------------ANS--- A_carolinensis_ENSACAP00000001746 --MRSMNTSVMSQFNLLN--GSMDQ--STDS-RAASS-----------------------------------SPYNSEHASN--VPTLSPYSQPSS---------------TFDTMS--- T_rubripes_ENSTRUP00000008025 H-EPEDT--FTSQYTNLGLLNSMDQ--NIQNGGSTST-----------------------------------SPYNNDHAQNN-VTAPSPYAQPSS---------------TFDALS--- X_tropicalis_ENSXETP00000010981 --MRTMNESIMSQFNLLN--NTMDQ--SIGS-RAAST-----------------------------------SPYNPDHTSN--VPTHSPYSQPSS---------------TFDAMS--- T_nigroviridis_ENSTNIP00000016776 H-EPEET--FTSQYTNLGLLNSMDQ--NIQNGGSTST-----------------------------------SPYNNDHAQNN-VTAPSPYAQPSS---------------TFDALS--- C_familiaris_ENSCAFP00000028819 --LQGMTTPVMSQFNLLS--STMDQ---MSS-RAASA-----------------------------------SPYTPEHAAS--VPTHSPYAQPSS---------------TFDTMS--- H_sapiens_ENSP00000367545 --LEGMTTSVMAQFNLLS--STMDQ---MSS-RAASA-----------------------------------SPYTPEHAAS--VPTHSPYAQPSS---------------TFDTMS--- C_familiaris_ENSCAFP00000020585 Q-DSDLSDPMWPQYTNLGLLNSMDQ--QIQN-GSSST-----------------------------------SPYNTDHAQNS-VTAPSPYAQPSS---------------TFDALS--- T_rubripes_ENSTRUP00000030645 -------DVCMHPDSPVSQLMNYPE-----------------------------------------------LPFNEELFNLPSEMASKDS-----------------------ANL--- B_taurus_ENSBTAP00000007643 ------SPSRQSQFNLLS--STMDQ---MSS-RAASA-----------------------------------SPYTPEHAAS--VPTHSPYAQPSS---------------TFDTMS--- O_latipes_ENSORLP00000019616 H-EPDETVSCWSQYTNLGLLNNM-E--NIQS-SSTST-----------------------------------SPYNNDHAQNN-VTAPSPYAQPSS---------------TFDALS--- M_mulatta_ENSMMUP00000021768 --LEGMTTSVMAQFNLLS--STMDQ---MSS-RAASA-----------------------------------SPYTPEHAAS--VPTHSPYAQPSS---------------TFDTMS--- M_musculus_ENSMUSP00000101269 --LQG-----MAQFNLLS--SAMDQ---MGS-RAAPA-----------------------------------SPYTPEHAAS--APTHSPYAQPSS---------------TFDTMS--- R_norvegicus_ENSRNOP00000052265 -----------AQFNLLS--SAMDQ---MGS-RAAPA-----------------------------------SPYTPEHAAS--APTHSPYAQPSS---------------TFDTMS--- G_gallus_ENSGALP00000001485 --MRGMNDSVMSQFNLLN--NSMDQ--SIGS-RAAST-----------------------------------SPYSSEHTSN--VPTHSPYSQPSS---------------TFDAMS--- G_aculeatus_ENSGACP00000008676 --MRDMNANVMSQYNLLS--SSM-E--SLGS-RATSA-----------------------------------SPYSSENASSSAVPTPSPYSQPNS---------------TFEGLS--- O_anatinus_ENSOANP00000021753 Q-DADVSDPMWPQYTNLGLLNSMDQ--QIQN-GSSST-----------------------------------SPYNTDHAQNS-VTAPSPYAQPSS---------------TFDALS--- M_mulatta_ENSMMUP00000021634 Q-DSDLSDPMWPQYTNLGLLNSMDQ--QIQN-GSSST-----------------------------------SPYNTDHAQNS-VTAPSPYAQPSS---------------TFDALS--- P_pygmaeus_ENSPPYP00000016106 Q-DSDLSDPMWPQYTNLGLLNSMDQ--QIQN-GSSST-----------------------------------SPYNTDHAQNS-VTAPSPYAQPSS---------------TFDALS--- D_rerio_ENSDARP00000074096 RDMRDMNDNVMSQYSLLS--SSMDQ--GLGN-RAAST-----------------------------------SPYSSETTSN--VPTPSPYSQPNS---------------TFEAMS--- H_sapiens_ENSP00000264731 Q-DSDLSDPMWPQYTNLGLLNSMDQ--QIQN-GSSST-----------------------------------SPYNTDHAQNS-VTAPSPYAQPSS---------------TFDALS--- P_troglodytes_ENSPTRP00000027067 Q-DSDLSDPMWPQYTNLGLLNSMDQ--QIQN-GSSST-----------------------------------SPYNTDHAQNS-VTAPSPYAQPSS---------------TFDALS--- R_norvegicus_ENSRNOP00000033463 Q-DSDLSDPMWPQYTNLGLLNGMDQ--QIQN-GSSST-----------------------------------SPYNTDHAQNS-VTAPSPYAQPSS---------------TFDALS--- M_musculus_ENSMUSP00000110965 Q-DSDLSDPMWPQYTNLGLLNSMDQ--QIQN-GSSST-----------------------------------SPYNTDHAQNS-VTAPSPYAQPSS---------------TFDALS--- O_cuniculus_ENSOCUP00000014157 Q-DSDLGDPMWPQYTNLGLLNSMDQ--QIQN-GSSST-----------------------------------SPYNTDHAQNS-VTAPSPYAQPSS---------------TFDALS--- E_caballus_ENSECAP00000016315 Q-DSDLSDPMWPQYTNLGLLNSMDQ--QIQN-GSSST-----------------------------------SPYNTDHAQNS-VTAPSPYAQPSS---------------TFDALS--- T_rubripes_ENSTRUP00000038165 --LRDMNDNVMSQYNLLS--SSM-E--SLGS-RATSA-----------------------------------SPYSSENASSSAVPTPSPYSQPNS---------------TFEGLS--- M_domestica_ENSMODP00000018831 Q-DSDLSDPMWPQYTNLGLLNSMDQ--QIPN-GSSST-----------------------------------SPYNTDHAQNS-VTAPSPYAQPSS---------------TFDALS--- G_aculeatus_ENSGACP00000025614 --LPLAHHNVWQDGNMEALLP---------------------------------------------------EGFDEKLFEFPPEVSTADG-----------------------VTP--- T_guttata_ENSTGUP00000002829 --MRGMTDSVMSQFNLLN--NSMDQ--SIGS-RAAST-----------------------------------SPYSSEHTSN--VPTHSPYSQPSS---------------TFDTMS--- G_gallus_ENSGALP00000011836 Q-DTELSDPMWPQYTNLGLLNSMDQ--QIQN-GSSST-----------------------------------SPYNTEHAQNS-VTAPSPYAQPSS---------------TFDALS--- T_guttata_ENSTGUP00000009686 Q-DTELNDPMWPQYTNLGLLNSMDQ--QIQN-GSSST-----------------------------------SPYNTEHAQNS-VTAPSPYAQPSS---------------TFDALS--- D_rerio_ENSDARP00000065136 E-TNAPSSYSEPQYTSLGLLNSMDQ-----NGGSTST-----------------------------------SPYNNDHAQNN-VTAPSPYAQPSS---------------TFEALS--- T_nigroviridis_ENSTNIP00000014938 --LRDMNDNVMSQYNLLS--SSM-E--SLGS-RATSA-----------------------------------SPYSSENASSSAVPTPSPYSQPNS---------------TFEGLS--- O_latipes_ENSORLP00000005521 --MRDTNDNVMSQYNLLS--SSM-E--SLGS-RATSA-----------------------------------SPYSSENASSSAVPTPSPYSQPNS---------------TFEGLS--- O_latipes_ENSORLP00000008029 --SWVATGDMFLLDQDLS------------------------------------------------------GTFDDKIFDIPIEPVPTNE-----------------------VNP--- E_caballus_ENSECAP00000001313 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000020544 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000015180 --LEGMTTSVMAQFNLLS--STMDQ---MSS-RAASA-----------------------------------SPYTPEHAAS--VPTHSPYAQPSS---------------TFDTMS--- G_gorilla_ENSGGOP00000005012 Q-DSDLSDPMWPQYTNLGLLNSMDQ--QIQN-GSSST-----------------------------------SPYNTDHAQNS-VTAPSPYAQPSS---------------TFDALS--- C_intestinalis_ENSCINP00000003956 EKHDGNEGSYQCLSNFPTSNPPMRS--YSNDMTQQNTINQHHPANMANLVTT---SSHPINQHNLVYHSTSPNTGDAPNSTQNSPYAPSPCGGYEY---------------PTSPLS--- C_intestinalis_ENSCINP00000004447 D-TTKANDIEFPVSEFLTSSQASQQ--SIGDLFAQ-------------------------------------SLPSTQCGGNSQVTTVSKHEYPDSGYVMTLPNNSVLAELQTSSLQ--- P_pygmaeus_ENSPPYP00000002277 --LEGMTTSVMAQFNLLS--STMDQ---MSS-RAASA-----------------------------------SPYTPEHAAS--VPTHSPYAQPSS---------------TFDTMS--- A_carolinensis_ENSACAP00000000376 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008216 ---------LQSQFNLLT--NTMDQ--NSSS-RAAST-----------------------------------SPYNPEHSAS--VPTHSPYSQPSS---------------TFDTMS--- O_anatinus_ENSOANP00000019815 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000000118 --LEGMTTSVM-QFHLLS--STMDQ---MSS-R-AWA-----------------------------------SPYTPEHAAS--VPTHSPYAQPSS---------------TFDTMS--- A_aegypti_AAEL007594-PA DAAQLVQIPTNEFLMDLDGDILDYH--EVLKLGSSGSS---------------------------LMGESGDHYMEQKPIV-------VVDQQTPL---------------MVALLD--- A_aegypti_AAEL007595-PA QQQQLQQQPSNYELKDWDSQTMELF--NSQTFADDASKVLRCGDF----------ATGSQDYELPISLKSLENLAPGESIN-VEVFNGQVDDTQPT---------------TTTNLD--- A_gambiae_AGAP002352-PA ----------------------------------------------------------------------------------------MLDGREEP---------------T-------- D_melanogaster_FBpp0083753 NEYAHLATPVDPAYGGNNTNNMMQFTNNLEILANNNSD----GNNKINACNKFVCHKGTDSEDDSTEVDIKEDIPKTVEVSGSELTTEPMAFLQGL---------------NSGNLMQFS A_gambiae_AGAP004319-PA EEDMFATGEGCSQISFLSSQLLEDHILGLDKTLNDSSATL--------------------------------ALSQTSPGVDIALPSSLLQDGKGS---------------LPSSLN--- 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000269305 ---------------LSSSVPSQKTYQGS-YGFRLGFLH--SGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDST---PPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSD---SDGL P_troglodytes_ENSPTRP00000014836 ---------------LSSSVPSQKTYQGS-YGFRLGFLH--SGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDST---PPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSD---SDGL G_gorilla_ENSGGOP00000009561 ---------------LSSSVPSQKTYQGS-YGFRLGFLH--SGTAKSVTCTYSPTLNKMFCQLAKTCPVQLWVDST---PPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSD---SDGL P_pygmaeus_ENSPPYP00000008923 ---------------LSSSVPSQKTYQGS-YGFRLGFLH--SGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDST---PPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSD---SDGL M_mulatta_ENSMMUP00000035274 ---------------LSSSVPSQKTYHGS-YGFRLGFLH--SGTAKSVTCTYSPDLNKMFCQLAKTCPVQLWVDST---PPPGSRVRAMAIYKQSQHMTEVVRRCPHHERCSD---SDGL O_cuniculus_ENSOCUP00000000989 ---------------LSSSVPSQKTYHGN-YGFRLGFLH--SGTAKSVTCTYSPCLNKLFCQLAKTCPVQLWVDST---PPPGSRVRAMAIYKKSQHMTEVVRSCPHHERCSD---SDGL C_familiaris_ENSCAFP00000024579 ---------------LSSSVPSPKTYPGT-YGFRLGFLH--SGTAKSVTWTYSPLLNKLFCQLAKTCPVQLWVSSP---PPPNTCVRAMAIYKKSEFVTEVVRRCPHHERCSDS--SDGL M_musculus_ENSMUSP00000104298 ---------------LSSFVPSQKTYQGN-YGFHLGFLQ--SGTAKSVMCTYSPPLNKLFCQLAKTCPVQLWVSAT---PPAGSRVRAMAIYKKSQHMTEVVRRCPHHERCSD---GDGL B_taurus_ENSBTAP00000001420 ---------------LSSFVPSQKTYPGN-YGFRLGFLQ--SGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVDSP---PPPGTRVRAMAIYKKLEHMTEVVRRCPHHERSSDY--SDGL R_norvegicus_ENSRNOP00000047840 ---------------LSSSVPSQKTYQGN-YGFHLGFLQ--SGTAKSVMCTYSISLNKLFCQLAKTCPVQLWVTST---PPPGTRVRAMAIYKKSQHMTEVVRRCPHHERCSD---GDGL E_caballus_ENSECAP00000006210 ---------------------------------------------------YSPTLNKLFCQLAKTCPVQLLVSSP---PPPGTRVRAMAIYKKSEFMTEVVRRCPHHERCSDS--SDGL D_rerio_ENSDARP00000051548 ---------------PTSTVPETSDYPGD-HGFRLRFPQ--SGTAKSVTCTYSPDLNKLFCQLAKTCPVQMVVDVA---PPQGSVVRATAIYKKSEHVAEVVRRCPHHERTPD---GDNL X_tropicalis_ENSXETP00000053761 ---------------TSSAVPSTEDYAGS-YGLKLEFQQ--NGTAKSVTCTYSTDLNKLFCQLAKTCPLLVRVERP---PPLGSILRATAVYKKSEHVAEVVKRCPHHERSVEP--GDDP G_aculeatus_ENSGACP00000018012 ---------------PSPAIPSNTDYAGT-HAFDVSFQQ--SSTAKSATWTYSTDLKKLYCQIAKTCPIQIKVLTN---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFN-DGQI T_nigroviridis_ENSTNIP00000013035 ---------------SCPTVPVTTDHPGE-YDFKLRFQK--SGTAKSVTSTYSESLNKLYCQLAKTSPLEVLLSRE---PPLGAMLRATAIYKKTEHVAEVVRRCPHHQN------EDST A_carolinensis_ENSACAP00000001746 ---------------PAPVIPSNTDYPGP-HHFEVTFQQ--SSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSGP---PPPGTIIRAMPVYKKAEHVTEVVKRCPNHELGRDFN-DGLS T_rubripes_ENSTRUP00000008025 ---------------PSPAIPSNTDYAGP-HTFDVSFQQ--SSTAKSATWTYSTELKKLYCQIAKTCPIQIKVLTT---PPQGAVVRAMPVYKKAEHVTEVVKRCPNHELSREFN-DGQM X_tropicalis_ENSXETP00000010981 ---------------PAPVIPSNTDYPGT-HNFEVTFQQ--SSTAKSATWTYSPLLKKLYCQIAKTCPIQIKLSNP---PPPGSVIRAMPVFKKAEHVTEVVKRCPNHELGRDFN-DGQA T_nigroviridis_ENSTNIP00000016776 ---------------PSPAIPSNTDYAGP-HTFDVSFQQ--SSTAKSATWTYSTDLKKLYCQIAKTCPIQIKVLTT---PPQGAVVRAMPVYKKAEHVTEVVKRCPNHELSREFN-DGQM C_familiaris_ENSCAFP00000028819 ---------------PAPAIPSNTDYPGP-HHFDVTFQQ--SSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTP---PPPGTVIRAMPVYKKAEHVTEVVKRCPNHELGRDFN-EGQS H_sapiens_ENSP00000367545 ---------------PAPVIPSNTDYPGP-HHFEVTFQQ--SSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTP---PPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFN-EGQS C_familiaris_ENSCAFP00000020585 ---------------PSPAIPSNTDYPGP-HSFDVSFQQ--SSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFN-EGQI T_rubripes_ENSTRUP00000030645 ---------------STPTVPVTTDYPGE-YGFELRFQK--SGTAKSVTSTYSEILNKLYCQLAKTSLVEVLLIKK---PPAGAVLRATAIYKKIEHVADVVRRCPHHQN------EDSA B_taurus_ENSBTAP00000007643 ---------------PAPVIPSNTDYPGP-HHFEVTFQQ--SSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSAP---PPPGTAIRAMPVYKKAEHVTEVVKRCPNHELGRDFN-EGQS O_latipes_ENSORLP00000019616 ---------------PSPAIPSNTDYAGP-HSFDVSFQQ--SSTAKSATWTYSTDLKKLYCQIAKTCPIQIKVLTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFN-DGQI M_mulatta_ENSMMUP00000021768 ---------------PAPVIPSNTDYPGP-HHFEVTFQQ--SSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTP---PPPGTAIRAMPVYKKAEHVTDIVKRCPNHELGRDFN-EGQS M_musculus_ENSMUSP00000101269 ---------------PAPVIPSNTDYPGP-HHFEVTFQQ--SSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTP---PPPGTAIRAMPVYKKAEHVTDIVKRCPNHELGRDFN-EGQS R_norvegicus_ENSRNOP00000052265 ---------------PAPVIPSNTDYPGP-HHFEVTFQQ--SSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTP---PPPGTAIRAMPVYKKAEHVTDIVKRCPNHELGRDFN-EGQS G_gallus_ENSGALP00000001485 ---------------PAPVIPSNTDYPGP-HHFEVTFQQ--SSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSSP---PPPGTIIRAMPVYKKAEHVTEVVKRCPNHELGRDFN-DGQS G_aculeatus_ENSGACP00000008676 ---------------PAPAIPSNTDYPGL-HTFQVSFQQ--SSTAKSATWTYSPLLKKLYCQIAKTCPIQIKLSSS---PPHGSIIRAMPVYKKAEHVTEVVKRCPNHELGRDFN-DGQA O_anatinus_ENSOANP00000021753 ---------------PSPAIPSNTDYPGP-HSFDVSFQQ--SSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFN-EGQI M_mulatta_ENSMMUP00000021634 ---------------PSPAIPSNTDYPGP-HSFDVSFQQ--SSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFN-EGQI P_pygmaeus_ENSPPYP00000016106 ---------------PSPAIPSNTDYPGP-HSFDVSFQQ--SSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFN-EGQI D_rerio_ENSDARP00000074096 ---------------PAPAIPSNTDYPGP-HNFEVTFQQ--SSTAKSATWTYSPLLKKLYCQIAKTCPIQIKLASS---PPNGSVIRAMPIYKKAEHVTEVVKRCPNHELGRDFN-ESQT H_sapiens_ENSP00000264731 ---------------PSPAIPSNTDYPGP-HSFDVSFQQ--SSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFN-EGQI P_troglodytes_ENSPTRP00000027067 ---------------PSPAIPSNTDYPGP-HSFDVSFQQ--SSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFN-EGQI R_norvegicus_ENSRNOP00000033463 ---------------PSPAIPSNTDYPGP-HSFDVSFQQ--SSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFN-EGQI M_musculus_ENSMUSP00000110965 ---------------PSPAIPSNTDYPGP-HSFDVSFQQ--SSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFN-EGQI O_cuniculus_ENSOCUP00000014157 ---------------PSPAIPSNTDYPGP-HSFDVSFQQ--SSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFN-EGQI E_caballus_ENSECAP00000016315 ---------------PSPAIPSNTDYPGP-HSFDVSFQQ--SSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFN-EGQI T_rubripes_ENSTRUP00000038165 ---------------PAPAIPSNTDYPGL-HAFQVSFQQ--SSTAKSATWTYSPLLKKLYCQIAKTCPIQMKLSSS---PPHGSIIRAMPIYKKAEHVTEVVKRCPNHELGRDFN-DGQT M_domestica_ENSMODP00000018831 ---------------PSPAIPSNTDYPGP-HSFDVSFQQ--SSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFN-EGQI G_aculeatus_ENSGACP00000025614 ---------------PASTVPVTSDHPGE-FGFQLRFQK--SGTAKSVTSTYSEILNKLYCQLAKTSLIEVLVTKE---LPTGALLRATAVYKKSDHVAEVVRRCPHHQK------EDAA T_guttata_ENSTGUP00000002829 ---------------PAPVIPSNTDYPGP-HHFEVTFQQ--SSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTS---PPPGTIIRAMPVYKKAEHVTEVVKRCPNHELGRDFN-DGQS G_gallus_ENSGALP00000011836 ---------------PSPAIPSNTDYPGP-HSFDVSFQQ--SSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFN-EGQI T_guttata_ENSTGUP00000009686 ---------------PSPAIPSNTDYPGP-HSFDVSFQQ--SSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFN-EGQI D_rerio_ENSDARP00000065136 ---------------PSPAIPSNTDYAGP-HTFDVSFQQ--SSTAKSATWTYSTELKKLYCQIAKTCPIQIKVLTN---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFN-DGQI T_nigroviridis_ENSTNIP00000014938 ---------------PAPTIPSNTDYPGL-HAFQVSFQQ--SSTAKSATWTYSPLLKKLYCQIAKTCPIQIKLSSS---PPHGSIIRAMPIYKKAEHVTEVVKRCPNHELGRDFN-DGQT O_latipes_ENSORLP00000005521 ---------------PAPAIPSNTDYPGP-HDFQVSFQQ--SSTAKSATWTYSPLLKKLYCQIAKTCPIQIKLVSS---PPHGSIIRAMPVYKKAEHVTEVVKRCPNHELGRDFN-DGQT O_latipes_ENSORLP00000008029 ---------------PPTTVPVTTDYPGS-YELELRFQK--SGTAKSVTSTYSETLNKLYCQLAKTSPIEVRVSKE---PPKGAILRATAVYKKTEHVADVVRRCPHHQN------EDSV E_caballus_ENSECAP00000001313 ---------------------------------------------------YSPLLKKLYCQIAKTCPIQIKVSTP---PPPGTAIRAMPVYKKAEHVTEVVKRCPNHELGRDLN-EGQS B_taurus_ENSBTAP00000020544 ---------------------------------------------------YSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFN-EGQI G_gorilla_ENSGGOP00000015180 ---------------PAPVIPSNTDYPGP-HHFEVTFQQ--SSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTP---PPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFN-EGQS G_gorilla_ENSGGOP00000005012 ---------------PSPAIPSNTDYPGP-HSFDVSFQQ--SSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFN-EXXX C_intestinalis_ENSCINP00000003956 ---------------SKPTIPPSTDYPGE-WDFQINFGEATESAPKSAQYTYSPIINKLFVKMNVTCPIKFKCARP---PPNGCVVRVMPVFKRPEHVTDIVTRCPNHKIPDQAQ---HI C_intestinalis_ENSCINP00000004447 ---------------TEVSLLPNNEYPGI-YNFEINFGEKTESAPKSAPFTYSYSLQKLFVKMNENCPIKFRCSPQ---PPSGCVIRAIPVFEKPNNVTEIVTRCFNHRNECRTESSDSN P_pygmaeus_ENSPPYP00000002277 ---------------PAPVIPSNTDYPGP-HHFEVTFQQ--SSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTP---PPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFN-EGQS A_carolinensis_ENSACAP00000000376 ---------------------------------------------------YSTELKKLYCQIAKTCPIQIKVMTP---PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFN-EGEP M_domestica_ENSMODP00000008216 ---------------PAPVIPSNTDYPGP-HHFEVTFQQ--SSTAKSATWTVSCLLLAL---------LRLSPPSL---PPPPSL---PPVLSGASLDEEVRPFCLHYRL---FG-RNQG O_anatinus_ENSOANP00000019815 ---------------------------------------------------------------------------------------------------------------------GQS P_troglodytes_ENSPTRP00000000118 ---------------PAPVIPSNTDYPGP-HHFEVTFQQ--SSTAKSATWTYSPLVKTLYCQIAKTCPILIK------------AIRAMPVY-IAEHVTDVHKRCPNHELGRDFN-E--- A_aegypti_AAEL007594-PA ---------------HMDRTPTLDEIENPVYNFNVDLNG--E-TSGKSSWMFSSRLNKVFVKMGQACTFNISYQAL---THQELFVRAMMVCSAPEDMHYPVYRCENHRGSDNVNPKLPN A_aegypti_AAEL007595-PA ---------------HLRQFPSVDPMIVPWINFQVSLPS--E-TSDKTSWMFSRKLQKLFVKMGNTCTFNVSQLPS---PDRDTTVRAMVVCSTPEDRHLPVSRCDNHRCSDNQD--IPD A_gambiae_AGAP002352-PA ---------------HYKKIPVLDDFTHPLLQFNVAISG---KPCSASAWCYSNALEKLFVKKKTPVTFDVTYMQP--SDYSRLKLRIMLVYSNSQYAYQTISRCQDDIAKDGAK---DF D_melanogaster_FBpp0083753 QQSVLREMMLQDIQIQANTLPKLENHNIGGYCFSMVLDE-----PPKSLWMYSIPLNKLYIRMNKAFNVDVQFKSK--MPIQPLNLRVFLCF--SNDVSAPVVRCQNHLSVEPLT-ANNA A_gambiae_AGAP004319-PA ---------------PTGKYPSVDELCPADIHFTVI-----PSSTQGSGFIFSEQLQKLFLKTDSICSFDIACQLPTFLPPTGWYVRVMLVSLAPESQHESITRCHKHIAHD----TGPE 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000269305 APPQHLIRVE--GNLRVEYLDDRNTF----RHSVVVPYEP----PEVG-SDCTTIHY----NYMCN-SSCM--GGMNRRPILTIITLEDSS---GNLLGRNSFEVRVCACPGRDRRTEEE P_troglodytes_ENSPTRP00000014836 APPQHLIRVE--GNLRVEYLDDRNTF----RHSVVVPYEP----PEVG-SDCTTIHY----NYMCN-SSCM--GGMNRRPILTIITLEDSS---GNLLGRNSFEVRVCACPGRDRRTEEE G_gorilla_ENSGGOP00000009561 APPQHLIRVE--GNLRVEYLDDRNTF----RHSVVVPYEP----PEVG-SDCTTIHY----NYMCN-SSCM--GGMNRRPILTIITLEDSS---GNLLGRNSFEVRVCACPGRDRRTEEE P_pygmaeus_ENSPPYP00000008923 APPQHLIRVE--GNLRVEYLDDRNTF----RHSVVVPYEP----PEVG-SDCTTIHY----NYMCN-SSCM--GGMNRRPILTIITLEDSS---GNLLGRNSFEVRVCACPGRDRRTEEE M_mulatta_ENSMMUP00000035274 APPQHLIRVE--GNLRVEYSDDRNTF----RHSVVVPYEP----PEVG-SDCTTIHY----NYMCN-SSCM--GGMNRRPILTIITLEDSS---GNLLGRNSFEVRVCACPGRDRRTEEE O_cuniculus_ENSOCUP00000000989 APPQHLIRVE--GNLRAEYLDDRNTF----RHSVVVPYEP----PEFG-SDCTTIHY----NYMCN-SSCM--GGMNRRPILTIITLEDSS---GNLLGRNSFEVRVCACPGRDRRTEEE C_familiaris_ENSCAFP00000024579 APPQHLIRVE--GNLRAKYLDDRNTF----RHSVVVPYEP----PEVG-SDYTTIHY----NYMCN-SSCM--GGMNRRPILTIITLEDSS---GNVLGRNSFEVRVCACPGRDRRTEEE M_musculus_ENSMUSP00000104298 APPQHLIRVE--GNLYPEYLEDRQTF----RHSVVVPYEP----PEAG-SEYTTIHY----KYMCN-SSCM--GGMNRRPILTIITLEDSS---GNLLGRDSFEVRVCACPGRDRRTEEE B_taurus_ENSBTAP00000001420 APPQHLIRVE--GNLRAEYLDDRNTF----RHSVVVPYES----PEID-SECTTIHY----NFMCN-SSCM--GGMNRRPILTIITLEDSC---GNLLGRNSFEVRVCACPGRDRRTEEE R_norvegicus_ENSRNOP00000047840 APPQHLIRVE--GNPYAEYLDDRQTF----RHSVVVPYEP----PEVG-SDYTTIHY----KYMCN-SSCM--GGMNRRPILTIITLEDSS---GNLLGRDSFEVRVCACPGRDRRTEEE E_caballus_ENSECAP00000006210 APPQHLIRVE--GNLRAEYLDDRNTF----RHSVVVPYEP----PEVG-SDCTTIHY----NFMCN-SSCM--GGMNRRPILTIITLEDSS---GNLLGRNSFEVRVCACPGRDRRTEEE D_rerio_ENSDARP00000051548 APAGHLIRVE--GNQRANYREDNITL----RHSVFVPYEA----PQLG-AEWTTVLL----NYMCN-SSCM--GGMNRRPILTIITLETQE---GQLLGRRSFEVRVCACPGRDRKTEES X_tropicalis_ENSXETP00000053761 APPSHLMRVE--GNSKAYYMEDVGTG----RHSVCVPYEG----PQVG-TECTTVLY----NYMCN-SSCM--GGMNRRPILTIITLESPE---GLLLGRRCFEVRVCACPGRDRRTEED G_aculeatus_ENSGACP00000018012 APPSHLIRVE--GNNHAQYVEDSITG----RQSVLVPYEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADED T_nigroviridis_ENSTNIP00000013035 ENRSHLIRME--GSQRAQYFEDPHTK----RQSVTVPYEP----PQLG-SEFTTILL----SFMCN-SSCM--GGMNRRPILAILTLETQE---GVVLGRRCFEVRVCACPGRDRKTEEA A_carolinensis_ENSACAP00000001746 APASHLIRVE--GNNLSQYVDDPVTG----RQSVMVPYEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRD---GQVLGRRSFEGRICACPGRDRKADED T_rubripes_ENSTRUP00000008025 APPSHLIRVE--GNNHAQYVEDTITG----RQSVLVPYEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADED X_tropicalis_ENSXETP00000010981 APASHLIRVE--GNNLSQYVDDPVTG----RQSVMVPYEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRD---GQVLGRRSFEGRICACPGRDRKADED T_nigroviridis_ENSTNIP00000016776 APPSHLIRVE--GNNHAQYVEDTITG----RQSVLVPYEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADED C_familiaris_ENSCAFP00000028819 APASHLIRVE--GNNLSQYVDDPVTG----RQSVMVPYEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRD---GQVLGRRSFEGRICACPGRDRKADED H_sapiens_ENSP00000367545 APASHLIRVE--GNNLSQYVDDPVTG----RQSVVVPYEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLEMRD---GQVLGRRSFEGRICACPGRDRKADED C_familiaris_ENSCAFP00000020585 APPSHLIRVE--GNSHAQYVEDPITG----RQSVLVPYEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADED T_rubripes_ENSTRUP00000030645 AHRSHLIRME--GSQRAQYFEDPHTK----RQSVTVPYEP----PQLG-SEFTTILL----SFMCN-SSCM--GGMNRRPILTILTLETQE---GVVLGRRCFEVRVCACPGRDRKTEEA B_taurus_ENSBTAP00000007643 APASHLIRVE--GNNLSQYVDDPVTG----RQSVMVPYEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRD---GQVLGRRSFEGRICACPGRDRKADED O_latipes_ENSORLP00000019616 APPSHLIRVE--GNNHAQYLEDSITG----RQSVLVPYEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADED M_mulatta_ENSMMUP00000021768 APASHLIRVE--GNNLSQYVDDPVTG----RQSVVVPYEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRD---GQVLGRRSFEGRICACPGRDRKADED M_musculus_ENSMUSP00000101269 APASHLIRVE--GNNLAQYVDDPVTG----RQSVVVPYEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILVIITLETRD---GQVLGRRSFEGRICACPGRDRKADED R_norvegicus_ENSRNOP00000052265 APASHLIRVE--GNNLSQYVDDPVTG----RQSVVVPYEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILVIITLETRD---GQVLGRRSFEGRICACPGRDRKADED G_gallus_ENSGALP00000001485 APASHLIRVE--GNNLSQYVDDPVTG----RQSVMVPYEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRD---GQVLGRRSFEGRICACPGRDRKADED G_aculeatus_ENSGACP00000008676 APASHLVRVE--GNNLSQYVDDPVTG----RQSVFLPYEA----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRE---GQVLGRRSFEGRICACPGRDRKADED O_anatinus_ENSOANP00000021753 APPSHLIRVE--GNSHAQYVEDPITG----RQSVLVPYEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADED M_mulatta_ENSMMUP00000021634 APPSHLIRVE--GNSHAQYVEDPITG----RQSVLVPYEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADED P_pygmaeus_ENSPPYP00000016106 APPSHLIRVE--GNSHAQYVEDPITG----RQSVLVPYEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADED D_rerio_ENSDARP00000074096 APASHLIRVE--GNNLCQYVDDPVTG----RQSVLVPYES----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRD---GQVLGRRSFEGRICACPGRDRKADED H_sapiens_ENSP00000264731 APPSHLIRVE--GNSHAQYVEDPITG----RQSVLVPYEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADED P_troglodytes_ENSPTRP00000027067 APPSHLIRVE--GNSHAQYVEDPITG----RQSVLVPYEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADED R_norvegicus_ENSRNOP00000033463 APPSHLIRVE--GNSHAQYVEDPITG----RQSVLVPYEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADED M_musculus_ENSMUSP00000110965 APPSHLIRVE--GNSHAQYVEDPITG----RQSVLVPYEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADED O_cuniculus_ENSOCUP00000014157 APPSHLIRVE--GNSHAQYVEDPITG----RQSVLVPYEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADED E_caballus_ENSECAP00000016315 APPSHLIRVE--GNSHAQYVEDPITG----RQSVLVPYEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADED T_rubripes_ENSTRUP00000038165 APASHLIRVE--GNNLCQYVDDPVTG----RQSVFVPYEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRD---GQVLGRRSFEARICACPGRDRKADED M_domestica_ENSMODP00000018831 APPSHLIRVE--GNSHAQYVEDPITG----RQSVLVPYEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADED G_aculeatus_ENSGACP00000025614 DHSSHLIRVE--GSQRAQYFEDPNTK----RQSVTVPYEL----PQLG-TEMTTILL----SFMCN-SSCM--GGMNRRPILTILTLETPE---GLVLGRRCFEVRVCACPGRDRKSEEI T_guttata_ENSTGUP00000002829 APASHLIRVE--GNNLSQYVDDPVTG----RQSVMVPYEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRD---GQVLGRRSFEGRICACPGRDRKADED G_gallus_ENSGALP00000011836 APPSHLIRVE--GNSHAQYVEDPITG----RQSVLVPYEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADED T_guttata_ENSTGUP00000009686 APPSHLIRVE--GNSHAQYVEDPITG----RQSVLVPYEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADED D_rerio_ENSDARP00000065136 APPSHLIRVE--GNSHAQYVEDSITG----RQSVLVPYEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADED T_nigroviridis_ENSTNIP00000014938 APASHLIRVE--GNNLCQYVDDPITG----RQ-VFVPYEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRDNISGQVLGRRSFEARICACPGRDRKADED O_latipes_ENSORLP00000005521 APANHLIRVE--GNNLCQYVDDPVTG----RQSAYVPYET----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRD---GQVLGRRSFEGRICACPGRDRKADED O_latipes_ENSORLP00000008029 EHRSHLIRVE--GSQLAQYFEDPYTK----RQSVTVPYEP----PQPG-SEMTTILL----SYMCN-SSCM--GGMNRRPILTILTLET-E---GLVLGRRCFEVRICACPGRDRKTEEE E_caballus_ENSECAP00000001313 APASHLIRVE--GNNLSQYVDDPVTG----RQSVMVPYEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRD---GQVLGRRSFEGRICACPGRDRKADED B_taurus_ENSBTAP00000020544 APPSHLIRVE--GNSHAQYVEDPITG----RQSVLVPYEP----PQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADED G_gorilla_ENSGGOP00000015180 APASHLIRVE--GNNLSQYVDDPVTG----RQSVVVPYEP----PQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRX---XXXXXXXXXXXXXXXXXXXXXXXXXX G_gorilla_ENSGGOP00000005012 XXXXXXXXXX--XXXXXXXXXXXXXX----XXXXXXXXXX----XXVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GQVLGRRCFEARICACPGRDRKADED C_intestinalis_ENSCINP00000003956 PHSQHLIRAEMPGENPAIY-NVAMDG----RENVAVMFER----PQIG-AEYTTVLY----KFMCL-SSCV--GGINRRPLNAVFNLENAE---GQVLGRRVVEVRVCSCPGRDRSQEEK C_intestinalis_ENSCINP00000004447 TPNSHLIRVE--SKSNNIQYCLTHEG----RECVVVPYEP----PHSG-SEYMALLY----RFMCL-SSCRTETGINRRPLLTIFNLESET---GELLGKRVVSTRICACPGRDRTQEEE P_pygmaeus_ENSPPYP00000002277 APASHLIRVE--GNNLSQYVDDPVTG----RQSVVVPYEP----PQ-------------------------------------------------------------------------- A_carolinensis_ENSACAP00000000376 DHPGSL-------SSHPLRVHWALLGDSKFNQDNHFPFCV----LQVG-TEFTTVLY----NFMCN-SSCV--GGMNRRPILIIVTLETRD---GNLLQLWRSWGHI-ARVGDDR----D M_domestica_ENSMODP00000008216 KVEGENMRTC--GLQWSRKEDDLVLA----KQ----PREPTATHPQVG-TEFTTILY----NFMCN-SSCV--GGMNRRPILIIITLETRD---GQVLGRRSFEGRICACPGRDRKADED O_anatinus_ENSOANP00000019815 APASHLIRVE--GNNLSQYVDDPVTG----RQSVMVPYEP----PQTD-DNIESLLYFSQIHHICNPSTCL--TGLKKTVLVVYCEQNTVR---GQVLGRRSFEGRICACPGRDRKADED P_troglodytes_ENSPTRP00000000118 --ASHLFRVK--ANNLSQYVDDPV-G----RQSVVVPYEP----PQ-------------------------------------------------------------------------- A_aegypti_AAEL007594-PA EVKAHVMRCF---NPSARYVGTENGVAFKDRLAVIIPLGM----TSQE-QVALNVSL----EFVCQ-NSC---RIINRRTTAIIFTLEDVH---GQILGKKSLHLKVCSCPKRDKMKEEE A_aegypti_AAEL007595-PA SIKTHIVRCK---NEQVTYTGTKDGKTFEERLAVLVPMG--------H-SAKTGITL----EFVCQ-NSC---RNINRRATALVFTLEDQA---GRILGRQVFQIKICTNIKRDMVNEEK A_gambiae_AGAP002352-PA AHKEHVVRCL---NPDASFTGREKGVNFEDRLAVLVDLNNGGTPQHLEKQQTVPVSL----EFLCQ-NSC---PTMERRATTLVFTVENEH---GTLLGRKSISVKICSCPKRDMEKDDS D_melanogaster_FBpp0083753 KMRESLLRSE---NPNSVYCGNAQGKGISERFSVVVPLNMSRSVTRSG-LTRQTLAF----KFVCQ-NSC-----IGRKETSLVFCLEKAC---GDIVGQHVIHVKICTCPKRDRIQDER A_gambiae_AGAP004319-PA EIRKHVVRCK---NEQHEYVGADNGPFFEDRYAVRVPLDD-------E-VLCVKIML----QFVCQ-NTC---FRLDQRRTGLVFTLENDQ---GNIWARRVVPVKICINYRRDMQNEQN 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000269305 NLRKKGEPHHELP-------PGSTK------RALPNN-TSS--------------------------SPQP-KKK-------PLDGE------Y------FTLQIRGRERFEMFRELNEA P_troglodytes_ENSPTRP00000014836 NLRKKGEPHHELP-------PGSTK------RALPNN-TSS--------------------------SPQP-KKK-------PLDGE------Y------FTLQIRGRERFEMFRELNEA G_gorilla_ENSGGOP00000009561 NLRKKGEPHHELP-------PGSTK------RALPNN-TSS--------------------------SPQP-KKK-------PLDGE------Y------FTLQIRGRERFEMFRELNEA P_pygmaeus_ENSPPYP00000008923 NFRKKGEPHHELP-------PGSTK------RALPNN-TSS--------------------------SPQP-KKK-------PLDGE------Y------FTLQIRGRERFEMFRELNEA M_mulatta_ENSMMUP00000035274 NFRKKGEPCHQLP-------PGSTK------RALPNN-TSS--------------------------SPQP-KKK-------PLDGE------Y------FTLQIRGRERFEMFRELNEA O_cuniculus_ENSOCUP00000000989 NFRKKGEPCPELP-------PGSSK------RALPTT-TTD--------------------------SSPQTKKK-------PLDGE------Y------FILKIRGRERFEMFRELNEA C_familiaris_ENSCAFP00000024579 NFHKKGEPCPEPP-------PGSTK------RALPPS-TSS--------------------------SPPQ-KKK-------PLDGE------Y------FTLQIRGRERYEMFRNLNEA M_musculus_ENSMUSP00000104298 NFRKKEVLCPELP-------PGSAK------RALPTC-TSA--------------------------SPPQ-KKK-------PLDGE------Y------FTLKIRGRKRFEMFRELNEA B_taurus_ENSBTAP00000001420 NLRKKGQSCPEPP-------PRSTK------RALPTN-TSS--------------------------SPQP-KKK-------PLDGE------Y------FTLQIRGFKRYEMFRELNDA R_norvegicus_ENSRNOP00000047840 NFRKKEEHCPELP-------PGSAK------RALPTS-TSS--------------------------SPQQ-KKK-------PLDGE------Y------FTLKIRGRERFEMFRELNEA E_caballus_ENSECAP00000006210 NFRKKEEPCPEPP-------PRSTK------RVLSSN-TSS--------------------------SPPQ-KKK-------PLDGE------Y------FTLQIRGRERFEMFRELNEA D_rerio_ENSDARP00000051548 NFKKDQETK-TMAKT-----TTGTK------RSLVKE-SSSATLR----------------------PEGSKKAK-----GSSSDEE------I------FTLQVRGRERYEILKKLNDS X_tropicalis_ENSXETP00000053761 NCTKKRGL------------KPNGK------RELSHP-PSS--------------------------DPPLPKKR--LIGSVPLTAV------T------FRLQIKGRSRYEMIKKLNDA G_aculeatus_ENSGACP00000018012 GIRKQHVTD--ATKG-----GDG----------FRQV-SHGIPM------------------------STIKKRR-------STDEE------V------FCLPIKGREIYEILVKIKES T_nigroviridis_ENSTNIP00000013035 NSTKMQTET-----------KDAKK------RKSAP--TSD--------------------------STTVKKSR-TASSAEEDDKE------V------FTLQIRGRKRYEMIKRINDG A_carolinensis_ENSACAP00000001746 HYREQQALNESAAKN-----GNPNK------RTFKQS-PQGMPAL----------------------GAGMKKRR-------HGEEE------T------YYVPVRGRENFEILMKIKES T_rubripes_ENSTRUP00000008025 SIRKQHVTD--ATKS-----SEGTK------HPFRQV-SHGIQM------------------------STIKKRR-------STDEE------V------FCLPIKGREIYEILVKIKES X_tropicalis_ENSXETP00000010981 HFREQAALNETAAKN-----GNANK------RTFKQS-PPSVPSM----------------------GSNIKKRR-------HGEDE------I------FYIPVRGRENFEILMKIKES T_nigroviridis_ENSTNIP00000016776 SIRKQHVTD--ATKS-----SEGTK------HPFRQV-SHGIQM------------------------STIKKRR-------STDEE------V------FCLPIKGREIYEILVKIKES C_familiaris_ENSCAFP00000028819 HYREQQALSESAAKN-----GAASK------RAFKQS-PPAVPAL----------------------GANVKKRR-------HGDED------V------YYMHVRGRENFEVLMKVKES H_sapiens_ENSP00000367545 HYREQQALNESSAKN-----GAASK------RAFKQS-PPAVPAL----------------------GAGVKKRR-------HGDED------T------YYLQVRGRENFEILMKLKES C_familiaris_ENSCAFP00000020585 SIRKQQVSD--SAKN-----GDGTK------RPFRQN-THGIQM------------------------TSIKKRR-------SPDDE------L------LYLPVRGRETYEMLLKIKES T_rubripes_ENSTRUP00000030645 NSTNMQNGT-----------KETKK------RKSVPP-PAA--------------------------AAAAKKSK-TASSAEEDDKE------L------FTLQIRGRKRYEMLKKINDG B_taurus_ENSBTAP00000007643 HYREQQALNESAAKS-----GAASK------RAFKQS-PPTAPAL----------------------GTNVKKRR-------HGDDD------V------YYIHVRGRENFEILMKVKES O_latipes_ENSORLP00000019616 SIRKQHVTD--ASKS-----SEGTK------RRYRQV-SHGIQM------------------------STIKKRR-------STDEE------V------FCLPIKGREIYEILVKIKES M_mulatta_ENSMMUP00000021768 HYREQQALNESSTKN-----GAAGK------RAFKQS-PPAVPAL----------------------GPGVKKRR-------HGDED------T------YYLQVRGRENFEILMKLKES M_musculus_ENSMUSP00000101269 HYREQQALNESTTKN-----GAASK------RAFKQS-PPAIPAL----------------------GTNVKKRR-------HGDED------M------FYMHVRGRENFEILMKVKES R_norvegicus_ENSRNOP00000052265 HYREQQALNESTTKN-----GAASK------RAFKQS-PPAIPAL----------------------GTNVKKRR-------HGDED------M------FYMHVRGRENFEILMKVKES G_gallus_ENSGALP00000001485 HYREQQALNENAAKN-----GNANK------RTFKQS-PQAIPAL----------------------GPGVKKRR-------HGEEE------M------YYVPVRGRENFEILMKIKES G_aculeatus_ENSGACP00000008676 HFREQQALHESVAKN-----GTANK------RNFKQS-PPNIPSP----------------------NINMRKRR-------HGEEE------I------YYIPVRGRENFELLMKIKDS O_anatinus_ENSOANP00000021753 SIRKQQVSD--STKN-----GDGTK------RPFRQS-THGIQM------------------------TSIKKRR-------SPDDE------L------LYLPVRGRETYEMLLKIKES M_mulatta_ENSMMUP00000021634 SIRKQQVSD--STKN-----GDGTK------RPFRQN-THGIQM------------------------TSIKKRR-------SPDDE------L------LYLPVRGRETYEMLLKIKES P_pygmaeus_ENSPPYP00000016106 SIRKQQVSD--STKN-----GDGTK------RPFRQN-THGIQM------------------------TSIKKRR-------SPDDE------L------LYLPVRGRETYEMLLKIKES D_rerio_ENSDARP00000074096 HFREQQALNESVAKN-----GNANK------RNFKQT-PTNITGP----------------------SINIKKRR-------HGEEE------M------YYIPVRGRENFDILMKIKDS H_sapiens_ENSP00000264731 SIRKQQVSD--STKN-----GDGTK------RPFRQN-THGIQM------------------------TSIKKRR-------SPDDE------L------LYLPVRGRETYEMLLKIKES P_troglodytes_ENSPTRP00000027067 SIRKQQVSD--STKN-----GDGTK------RPFRQN-THGIQM------------------------TSIKKRR-------SPDDE------L------LYLPVRGRETYEMLLKIKES R_norvegicus_ENSRNOP00000033463 SIRKQQVSD--SAKN-----GDGTK------RPFRQN-THGIQM------------------------TSIKKRR-------SPDDE------L------LYLPVRGRETYEMLLKIKES M_musculus_ENSMUSP00000110965 SIRKQQVSD--SAKN-----GDGTK------RPFRQN-THGIQM------------------------TSIKKRR-------SPDDE------L------LYLPVRGRETYEMLLKIKES O_cuniculus_ENSOCUP00000014157 SIRKQQVSD--STKN-----GDGTK------RPFRQN-THGIQM------------------------TSIKKRR-------SPDDE------L------LYLPVRGRETYEMLLKIKES E_caballus_ENSECAP00000016315 SIRKQQVSD--STKN-----GDGTK------RPFRQN-THGIQM------------------------TSIKKRR-------SPDDE------L------LYLPVRGRETYEMLLKIKES T_rubripes_ENSTRUP00000038165 HFREQQALSDSVDKN-----GSANK------RNFKQS-LPTIQNP----------------------NLNSRKRR-------HGEED------L------YYIPVRGRENFELLMKIKDS M_domestica_ENSMODP00000018831 SIRKQQVSD--SSKN-----GDGTK------RPFRQN-THGIQM------------------------TSIKKRR-------SPDDE------L------LYLPVRGRETYEMLLKIKES G_aculeatus_ENSGACP00000025614 KSKTQIGT------------KQTTK------RKNPAP-TP---------------------------NTSEKKAK-SASSAEEEDKD------V------FVLRVRGRERYEWLKKIHDG T_guttata_ENSTGUP00000002829 HFREQQALNESTAKN-----GNANK------RTFKQS-PQGIPAL----------------------GTGIKKRR-------HGEEE------M------YYVPVQGRENFEILMKIKES G_gallus_ENSGALP00000011836 SIRKQQVSD--STKN-----GDGTK------RPFRQG-THGIQM------------------------TSIKKRR-------SPDDE------L------LYLPVRGRETYEMLLKIKES T_guttata_ENSTGUP00000009686 SIRKQQVSD--STKN-----GDGTK------RPFRQG-THGIQM------------------------TSIKKRR-------SPDDE------L------LYLPVRGRETYEMLLKIKES D_rerio_ENSDARP00000065136 SIRKQHVTD--GTKS-----SEA----------FRQASSHLSQL------------------------NSIKKRR-------STDEE------V------FCLPIKGREIYEILVKIKES T_nigroviridis_ENSTNIP00000014938 HFREQQALSDSVDKN-----GSANK------RNFKQS-LPNIQNP----------------------NLNTRKRR-------HGEED------V------YYIPVRGRENFELLMKIKDS O_latipes_ENSORLP00000005521 HFREQQALNESVAKN-----GSANK------RNFKQS-PPNIPNP----------------------NMNMRKRR-------HGEEE------I------YYIPVRGRENFELLMRIKDS O_latipes_ENSORLP00000008029 SRQKTQP----------------KK------RSMLEV-TPN--------------------------TSSSKRKKSHSSGEEEDNRE------V------FHFEVYGRERYEFLKKINDG E_caballus_ENSECAP00000001313 HYREQQALNESAAKN-----AAAGK------RAFKQS-PPAIPAL----------------------GTNVKKRR-------HGDED------T------YYMHVRGRENFEILMKVKES B_taurus_ENSBTAP00000020544 SIRKQQVSD--STKN-----GDGTK------RPFRQN-THGIQM------------------------TSIKKRR-------SPDDE------L------LYLPVRGRETYEMLLKIKES G_gorilla_ENSGGOP00000015180 XXXXXXXXXESSAKN-----GAASK------RAFKQS-PPAVPAL----------------------GAGVKKRR-------HGDED------T------YYLQXXXXXXXXXXXXXXXX G_gorilla_ENSGGOP00000005012 SIRKQQVSD--STKN-----GDGTK------RPFRQN-THGIQM------------------------TSIKKRR-------SPDDE------L------LYLPVRGRETYEMLLKIKES C_intestinalis_ENSCINP00000003956 RKRTAES------EV-----KSGSK------RTYKCM-QGSMNIV----------------------QTAPAKRK--CAMNGNDDQE------E------FTLKIRGRDKFEMLKKIKEA C_intestinalis_ENSCINP00000004447 KKNVTSQ-------------NKSRK------RLCKSA-TNSKS------------------------IPVVQKNEENKVDNDDDGDV------V------YTLNIRGKRKFEKVKEYKEA P_pygmaeus_ENSPPYP00000002277 --------------------------------------------------------------------------------------------------------VRGRENFEILMKLKES A_carolinensis_ENSACAP00000000376 VVSIENIQS--NEHN-----VPLITFFLPV-TAFRQS-THGIQM------------------------TSVKKRR-------TPDDE------L------LYLPVRGRETYEMLLKIKES M_domestica_ENSMODP00000008216 HYREQQALNESAAKN-----GNATK------RTFKQS-PPAIPAL----------------------VANVKKRR-------HGDEE------I------YYMPVRGRENFEILMKIKES O_anatinus_ENSOANP00000019815 HYREQQALNESAAKN-----GNANK------RTFKQS-PPAVPAL----------------------GTTVKKRR-------HGDEE------M------YYVPVRGRENFEILMKIKES P_troglodytes_ENSPTRP00000000118 ---------------------GAAK------RAFKQS-PPAVPAL----------------------GAGVKKRR-------HGDED------T------YYLQ---------------- A_aegypti_AAEL007594-PA TV---APTKRKSDTQLQAPPGKKIAKVATLSRQIAAQ-QQQLQQRRLTPSPTSGKLAFIKREISAESLNGCNQKA-RSITPSHSQEM------VEANGIPVTVLLPSVEMANKVAEYAFQ A_aegypti_AAEL007595-PA AVMEESSRKRKAAAQ-----SWEHKRGKKIVRYHSGL-PLSHSQT----------------------SAGIQIKEESGNRRCNIDPV------T------FTVTMPNRRMARRMLDIGIG A_gambiae_AGAP002352-PA KATGGRE-------------NNKNK------RKHAATPLLGQIKREPSFTPLGY-------------SLSNLSNSSNSTIDNDSSAV------V------LTLRLPDLACASEVAMYAFK D_melanogaster_FBpp0083753 QLNSKKRKSVPEAAE-----EDEPS------KVRRCI------------------------------AIKTEDTESNDSRDCDDSAAEWNVSRTPDGDYRLAITCPNKEWLLQSIEGMIK A_gambiae_AGAP004319-PA SAINFLPTSCLTAGRSDAP-GTSAV------RRYKAGRPGKRLQRGGKLGPGGG-------------SVNRADRTVPVRAARNIEPC------T------VNIEMPSLRMAKRVMDNAIG 610 620 630 640 650 660 670 680 690 700 710 720 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000269305 LELKDAQAGK-EPGG-SR--AHSS------HLKSK--KGQSTSRHK-------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000014836 LELKDAQAGK-EPGG-SR--AHSS------HLKSK--KGQSTSRHK-------------------------------------------------------------------------- G_gorilla_ENSGGOP00000009561 LELKDAQAGK-EPGG-SR--AHSS------HLKSK--KGQSTSRHK-------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000008923 LELKDAQAGK-EPGG-SR--AHSS------HLKSK--KGQSTSRHK-------------------------------------------------------------------------- M_mulatta_ENSMMUP00000035274 LELKDAQAGK-EPAG-SR--AHSS------HLKSK--KGQSTSRHK-------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000000989 LELKDAQAEK-EPGG-SR--AHSS------YLKAK--KGQSTSRHK-------------------------------------------------------------------------- C_familiaris_ENSCAFP00000024579 LELKDAQSGK-EPGG-SR--AHSS------HLKAK--KGQSTSRHK-------------------------------------------------------------------------- M_musculus_ENSMUSP00000104298 LELKDAHATE-ESGD-SR--AHSS------YLKTK--KGQSTSRHK-------------------------------------------------------------------------- B_taurus_ENSBTAP00000001420 LELKDALDGR-EPGE-SR--AHSS------HLKSK--KRPSPSCHK-------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000047840 LELKDARAAE-ESGD-SR--AHSS------YPKTK--KGQSTSRHK-------------------------------------------------------------------------- E_caballus_ENSECAP00000006210 LELKDAQTGK-EPGG-SK--AHSS------HLKSK--KGQSTSSHK-------------------------------------------------------------------------- D_rerio_ENSDARP00000051548 LELSDVVPAS-DAEK-YR--QKFM------TKNKK--ENRESSEPKQGK----------------------------------------------------------------------- X_tropicalis_ENSXETP00000053761 LELQESLDQQ-KLSIKCR-------------------KCRDEIKPKKGK----------------------------------------------------------------------- G_aculeatus_ENSGACP00000018012 LELMQFLPQH-TIES-YR--QQQQ------NLLQK--QRHSVSFTVLFPA---------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000013035 LDLLENKTKS-KTT--YK---------------------PEGPVLPSGK----------------------------------------------------------------------- A_carolinensis_ENSACAP00000001746 MELVELVPQQ-LVDS-YR--QQQQ------QLLQR--QTHLQPPSSYGPVLSPMNKLHA-GGVNKLPSVNQLVGQPQQHGPNTGP-NLGPM---GPGIL------------NS--HPMQS T_rubripes_ENSTRUP00000008025 LELMQFLPQH-TIES-YR--QQQQ------NLLQK--QTSVPSQPSYGSCSPTHGK------VNKLPSVSQLMNPQQRNTLTPSS-MSGGL---TD-MS------------PMMGTHVPM X_tropicalis_ENSXETP00000010981 LELVELVPQQ-LVDS-YR--QQQQ------QLLQR--QTHLQSTSSYGPVLSPMNKLH--GGINKLPSVNQLVGQPNQHNSNAGP-NMGPM---GPSML------------NS--HPLQT T_nigroviridis_ENSTNIP00000016776 LELMQFLPQH-TIES-YR--QQQQ------SLLQK--QTSVPSQPSYGSCSPTHGK------VNKLPSVSQLMNPQQRNTLTPSS-MTGGL---AD-MS------------PMMGTHVPM C_familiaris_ENSCAFP00000028819 LELMELVPQQ-LVDT-YQ-MTRSC------CCLSR---SHLQPA-SYGPVLSPMNKAH--GGVNKLPSVNQLVGQPPPHGSAAGP-NLGPM---GPGIL------------NNHGHALPA H_sapiens_ENSP00000367545 LELMELVPQP-LVDS-YR---QQQ------QLLQR--PSHLQPP-SYGPVLSPMNKVH--GGMNKLPSVNQLVGQPPPHSSAATP-NLGPV---GPGML------------NNHGHAVPA C_familiaris_ENSCAFP00000020585 LELMQYLPQH-TIETYYR--YHQQQIHHFTHLLKKSIKTSMQSQSTYGNSSPPLNKMN---SMNKLPSVSQLINPQQRNALTPTT-IPDGM---GA-NI------------PMMGTHMPM T_rubripes_ENSTRUP00000030645 LELLENKPKC-KAA--AK---------------------PECPVPPRGK----------------------------------------------------------------------- B_taurus_ENSBTAP00000007643 LELMELVPQQ-LVDS-YR--QQQQ------QLLQR--PSHLQPP-SYGPVLSPMSKAH--GAVNKLPSVNQLVGQPPPHGSAAGP-NLGPM---GPGIL------------NNHGHTLPA O_latipes_ENSORLP00000019616 LELMQFLPQH-TIES-YR--QQQQ------NLLQK--QTSMPSQPSFGSTSPTPGK------VNKLPSVSQLINPQQRNTLTPSS-MTGGL---TD-MT------------PMMAPHIPM M_mulatta_ENSMMUP00000021768 LELMELVPQP-LVDS-YR---QQQ------QLLQR--PSHLQPP-SYGPVLSPMNKVH--GGMNKLPSVNQLVGQPPPHSSAATP-NLGPV---GAGML------------NNHGHAVPA M_musculus_ENSMUSP00000101269 LELMELVPQP-LVDS-YR-QQQQQ------QLLQR--PSHLQPP-SYGPVLSPMNKVH--GGVNKLPSVNQLVGQPPPHSSAAGP-NLGPM---GSGML------------NSHGHSMPA R_norvegicus_ENSRNOP00000052265 LELMELVPQP-LVDS-YR-QQQQQ------QLLQR--PSHLQPP-SYGPVLSPMNKVH--GGVNKLPSVNQLVGQPPPHSSAAGP-NLGSM---GSGIL------------NSHSHSMPA G_gallus_ENSGALP00000001485 LELVELVPQQ-LVDS-YR--QQQQ------QLLQR--QNQLQTPSSYGPVLSPMNKAHG-GGINKLPSVNQLVGQPAQHSSGSAP-SLGPM---GPGML------------NS--HPMQP G_aculeatus_ENSGACP00000008676 LELVELVPQP-LVDS-YR-QQTQQ------QLLQR--PSHIASPSPYSP-LSNMNKQNVHGGLNKSPSVNQLVGQQSQQHPTGPA-SIVHM---GSNML------------NS--HHMQG O_anatinus_ENSOANP00000021753 LELMQYLPQH-TIET-YR--QQQQQQHQ--HLLQK--QSSMQSQ-SYGGNSPPLNKMN---SMNKLPSVSQLINPQQRNALTPTA-ISDGM---GA-NI------------PMMGTHMPM M_mulatta_ENSMMUP00000021634 LELMQYLPQH-TIET-YR--QQQQQQHQ--HLLQK--QTSIQSQSSYGNSSPPLNKMN---SMNKLPSVSQLINPQQRNALTPTT-IPDGM---GA-NI------------PMMGTHMPM P_pygmaeus_ENSPPYP00000016106 LELMQYLPQH-TIET-YR--QQQQQQHQ--HLLQK--QTSIQSQSSYGNSSPPLNKMN---SMNKLPSVSQLINPQQRNALTPTT-IPDGM---GA-NI------------PMMGTHMPM D_rerio_ENSDARP00000074096 LELVEFVPQQ-LVDS-YR--QQQQ------QLLQR--QNHVASPSSYGT-LNNMNKIH--GPISKLPSVNQLVTQQTQQSAGPSA-SLSHM---GANML------------GG--HHMQS H_sapiens_ENSP00000264731 LELMQYLPQH-TIET-YR--QQQQQQHQ--HLLQK--QTSIQSPSSYGNSSPPLNKMN---SMNKLPSVSQLINPQQRNALTPTT-IPDGM---GA-NI------------PMMGTHMPM P_troglodytes_ENSPTRP00000027067 LELMQYLPQH-TIET-YR--QQQQQQHQ--HLLQK--QTSIQSPSSYGNSSPPLNKMN---SMNKLPSVSQLINPQQRNALTPTT-IPDGM---GA-NI------------PMMGTHMPM R_norvegicus_ENSRNOP00000033463 LELMQYLPQH-TIET-YR--QQQQQQHQ--HLLQK--QTSMQSQSSYGNSSPPLNKMN---SMNKLPSVSQLINPQQRNALTPTT-MPEGM---GA-NI------------PMMGTHMPM M_musculus_ENSMUSP00000110965 LELMQYLPQH-TIET-YR--QQQQQQHQ--HLLQK--QTSMQSQSSYGNSSPPLNKMN---SMNKLPSVSQLINPQQRNALTPTT-MPEGM---GA-NI------------PMMGTHMPM O_cuniculus_ENSOCUP00000014157 LELMQYLPQH-TIET-YR--QQQQQQHQ--HLLQK--XXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXALTPLAPIPDGM---GA-HI------------PMMGTHMPM E_caballus_ENSECAP00000016315 LELMQYLPQH-TIET-YR--QQQQQQHQ--HLLQK--QTSMQSQSSYGNSSPPLNKMN---SMNKLPSVSQLINPQQRNALTPTT-IPDGM---GA-NI------------PMMGTHMPM T_rubripes_ENSTRUP00000038165 LELVELVPQP-LLDS-YR--QQTQ------QLLQR--PGHISSPSSYSP-LSNMNKLHNQGGISKPPSSINLMGQQPQQHHTAPS-SLTHM---GSSML------------SS--HHMQA M_domestica_ENSMODP00000018831 LELMQYLPQH-TIET-YR--QQQQQQHQ--HLLQK--QTSMQSQTSYGTSSPPLSKMN---SINKLPSVSQLINPQQRNALTPTA-IPDGM---GA-NI------------PMMGTHMPM G_aculeatus_ENSGACP00000025614 LELLDRERLS-KPTVSVK---------------------HEAAAPSGGK----------------------------------------------------------------------- T_guttata_ENSTGUP00000002829 LELVELVPQQ-LVDS-YR--QQQQ------QLLQR--QSQLQTASSYGPVLSPMNKVHG-GGINKLPSVNQLVGQPAQHGSSSAP-SLGPM---GPGML------------NS--HPMQT G_gallus_ENSGALP00000011836 LELMQYLPQH-TIET-YR--QQQQQQHQ--HLLQK--QTSIQSQSSYGSNSPPLSKMN---SMNKLPSVSQLINPQQRNALTPTT-IPDGM---GT-NI------------PMMGTHMAM T_guttata_ENSTGUP00000009686 LELMQFLPQH-TIET-YR--QQQQQQHQ--HLLQK--QTSMQSQSSYGSNSPPLSKMN---SMNKLPSVSQLINPQQRNALTPTT-IPDSM---GT-NI------------PMMGTHMAM D_rerio_ENSDARP00000065136 LELMQFLPQQ-TIES-YR--QQQQ------NLLQK--QSSLPPQPAFGSSSPTLGK-------NKLPSVSQLINPQQRNALTPSG-MPGGL---TDSLLQSQPFPLPSVTPPMMGGPVPM T_nigroviridis_ENSTNIP00000014938 LELVELVPQP-LLDS-YR--QQTQ------QFLQR--PGHISSPTSYSP-LSNMNKLHNQGGISK-PSSVNLMGQQPQQHHSAPS-SLAHM---GSNML------------SS--HHMQA O_latipes_ENSORLP00000005521 LELVELVPQP-LIDS-YR-HQTQQ------QMLQR--PSNINSPSSYSP-LSNMNKIHSHGGLSK-PSVNQMMGQQPQQH--ANS-SMSHM---GPNML------------NN--SHLQA O_latipes_ENSORLP00000008029 LELLEKESPT-NDSSAMK-------KKCLTAVIAK--KDIFCTQPTSRS----------------------------------------------------------------------- E_caballus_ENSECAP00000001313 LELMELVPQQ-LVDS-YRQQQQQQ------QLLQR--PSPLQSP-SYGPVLSPMNKAH--GGISKLPSVNQLVGQPPPHSSAAGP-NLGPM---GPGIL------------NNHGHALPA B_taurus_ENSBTAP00000020544 LELMQYLPQH-TIET-YR--QQQQQQHQ--HLLQK--QTSMQSQSSYGNSSPPLNKMN---SMNKLPSVSQLINPQQRNALTPTT-IPDGM---GA-NI------------PMMGTHMPM G_gorilla_ENSGGOP00000015180 XXXXXXXXXX-XXXX-XX---XXX------XXLQR--PSHLQPP-SYGPVLSPMNKVH--GGMNKLPSVNQLVGQPPPHSSAATP-NLGPV---GPGML------------NNHGHAVPA G_gorilla_ENSGGOP00000005012 LELMQYLPQH-TIET-YR--QQQQQQHQ--HLLQK--QTSIQSPSSYGNSSPPLSKMN---SMNKLPSVSQLINPQQRNALTPTT-IPDGM---GA-NI------------PMMGTHMPM C_intestinalis_ENSCINP00000003956 LDLAEVAAHQ-QVEN-YR--DEDA------RTFKV---EPSSIHGKYPK----------------------------------------------------------------------- C_intestinalis_ENSCINP00000004447 LDLLDYVQPD-VKKACCQ-------------------RNQI------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000002277 LELMELVPQP-LVDS-YR---QQQ------QLLQR--PSHLQPP-SYGPVLSPMNKVH--GGMNKLPSVNQLVGQPPPHSSAATP-NLGPV---GPGML------------NNHGHAVPA A_carolinensis_ENSACAP00000000376 LELMQYLPQH-TIET-YR--QQQQQQQQHQHLLQK--QASLQSPSSYGSNSPPLGKMN---SVNKLPSVSQLMNPQQRNALTPTS-LPDSM---GA-NI------------PMMG-HMAM M_domestica_ENSMODP00000008216 LELVDLVPQQ-LVDS-YR--QQQQ------QLLQR--PHWGDQALGMGQ------QAQKEGGDTKMP------GNSSPHSPISHL-QLLPFLSTGPGML------------NSHGHPMQS O_anatinus_ENSOANP00000019815 LELVELVPQQ-LVDS-YA-AGTTA------PLFPD--RSHLQSPSSYGPVLSPMNKVH--GVVNKLPSVNQLVGQPTAHSSAAGA-NLGPV---GPGML------------NSHGHPMQP P_troglodytes_ENSPTRP00000000118 -----------------------------------------------------------------------------------------------PGML------------NNHGHAVPA A_aegypti_AAEL007594-PA IVAAELVRSHADQDDSKKLAAYLT------NIRRV--QSKYEPFVM-------------------------------------------------------------------------- A_aegypti_AAEL007595-PA QISTAVVNTS-NDAERNELMQFVH------DIRRI--KSSFALPNSQ------------------------------------------------------------------------- A_gambiae_AGAP002352-PA HLSSILISCK-DEKDKNRYAQYLS------HCRRV--RSKYASSHR-------------------------------------------------------------------------- D_melanogaster_FBpp0083753 EAAAEVLRNP-NQENLRRHANKLL------SLKKR--AYELP------------------------------------------------------------------------------ A_gambiae_AGAP004319-PA MVSAQILLED-DTETKNRLKVFLD------SIRRQ--RDALAMSNSQ------------------------------------------------------------------------- 730 740 750 760 770 780 790 800 810 820 830 840 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000269305 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000014836 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000009561 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000008923 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000035274 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000000989 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000024579 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000104298 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001420 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000047840 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000006210 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000051548 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000053761 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018012 ------------------------------------------------------------------------------------------EHRML------------------------- T_nigroviridis_ENSTNIP00000013035 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000001746 NGDMNGGHSSQ------SMVSGAHCSPPPPYNPDPSLVSFLTGLGCSNCIDYFTSQGLQTLYQLQNLTLEDLVLLKIPEQYRMIIWRGLQDLKQG-----------HDYGAQ--QLIRSS T_rubripes_ENSTRUP00000008025 NADMSSLSPTHALQQQLPLVPSSHCTPPPPYPMDSSISSFLLRLGCAGCLDYFTAQGLTNIYQIENYNMEDLSRLKIPSEFQHIIWKGIMEHRQA-----------MDFSPP-PHIVRTT X_tropicalis_ENSXETP00000010981 NGEMNGAHSSQ------SMVSGSHCTPPPPYNADPSLVSFLTGLGCPNCIEYFTSQGLQNIYHLQNLTMEDLGALKIPEHYKSMIWRGIQELNKS-----------HEYGAQ--QLVRSS T_nigroviridis_ENSTNIP00000016776 NADMSSLSPTHALQPQLPLVPSSHCTPPPPYPMDSSISSFLLRLGCAGCLDYFTAQGLTNIYQIENYNMEDLSRLKIPSEFQHIIWKGIMEHRQA-----------MDFSPP-PHIVRST C_familiaris_ENSCAFP00000028819 SSEMNGSHSAQ------SMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIEYFTSQGLQNIYHLQNLTIEDLGALKIPDQYRMTIWRGLQDLKQS-----------HDYGAQ--QLIRSS H_sapiens_ENSP00000367545 NGEMSSSHSAQ------SMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMTIWRGLQDLKQG-----------HDYSTA--QQLLRS C_familiaris_ENSCAFP00000020585 AGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSLVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQL-----------HDFSSP-PHLLRTP T_rubripes_ENSTRUP00000030645 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000007643 NGEMNGGPSSQ------SMVSGSHCTPPPPYHADSSLVSFLTGLGCPNCIEYFTSQGLQNIYHLQNLTIEDLGALKIPDQYRMTIWRGLQDLKQS-----------HDYSAQ--QLIRSS O_latipes_ENSORLP00000019616 NADMSSLSPTHALQPQLPLVPSSHCTPPPPYPMDSSIASFLVRLGCAGCLDYFTAQGLSNIYQIENYNLEDLCRLKIPTEFQNIIWRGIMEHRQA-----------MDFSPP-PHIVRTT M_mulatta_ENSMMUP00000021768 NGEMSSSHSTQ------SMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIELIAGTMI-KQPRACLWPGAADRDEG-----------HTLSQL--QQLLRS M_musculus_ENSMUSP00000101269 NGEMNGGHSSQ------TMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIECFTSQGLQSIYHLQNLTIEDLGALKVPDQYRMTIWRGLQDLKQS-----------HDCG-Q--QLLRSS R_norvegicus_ENSRNOP00000052265 NGEMNGGHSSQ------TMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIECFTSQGLQSIYHLQNLTIEDLGALKIPDQYRMTIWRGLQDLKQS-----------HDCG-Q--QLLRSS G_gallus_ENSGALP00000001485 NGEMNGGHSSQ------SMVSGSHCTPPPPYNPDPSLVSFLTGLGCPNCIDYFTSQGLQNIYHLQNLSIEDLGALKIPEQYRMIIWRGLQELKQS-----------HDYGAQ--QLIRSS G_aculeatus_ENSGACP00000008676 NGDMNGGHSSQ------TIVSASHCSPPPPYNPDPSLVSFLTSLGCQNFIEYFTSQGLQSIYHLQTLSMEDLSALKIPEQFRLAIWRGLQDMKQVAPLQLPASTHHHDYHGQ--QLLRSS O_anatinus_ENSOANP00000021753 AGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQL-----------HDFSSP-PHLLRTP M_mulatta_ENSMMUP00000021634 AGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQL-----------HEFSSP-SHLLRTP P_pygmaeus_ENSPPYP00000016106 AGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQL-----------HEFSSP-SHLLRTP D_rerio_ENSDARP00000074096 NGDVNGAHQSQ------SIVSTSHCTPPPPYNPDPSLVSFLTSLGCQNCIDYFTSQGLQSVYHLQTLTMEDLGALKIPEQFRLAIWRGLQEMKQG-----------HDYGQ---QLIRSS H_sapiens_ENSP00000264731 AGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQL-----------HEFSSP-SHLLRTP P_troglodytes_ENSPTRP00000027067 AGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQL-----------HEFSSP-SHLLRTP R_norvegicus_ENSRNOP00000033463 AGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQL-----------HDFSSP-PHLLRTP M_musculus_ENSMUSP00000110965 AGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQL-----------HDFSSP-PHLLRTP O_cuniculus_ENSOCUP00000014157 AGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDXXXXXXXXXXXXXXXXXXXXXXXXX-----------XXXXXX-XXXXXXX E_caballus_ENSECAP00000016315 AGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSLVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQL-----------HDFSSP-PHLLRTP T_rubripes_ENSTRUP00000038165 NGDMNGSHSNQ------TIVSASHCSPPPPYNPDPSLVSFLTSLGCQNFIEYFASQGLQSVYHLQTLSMEDLGAMKIPEQSRLAIWRGLQDMKQGSPLQLPPSAHHHDYHGQ--QLIRSS M_domestica_ENSMODP00000018831 AGDMNGLSPTQALPPTLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQL-----------HDFSSP-PHLLRTP G_aculeatus_ENSGACP00000025614 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000002829 NGEMNGGHSSQ------SMVSGSHCTPPPPYNADPSLVSFLTGLGCPNCIDYFTSQGLQNIYHLQNLSIEDLAALKIPEQYRMLIWRGLQELKQS-----------HDYGAQ--QLIRSS G_gallus_ENSGALP00000011836 TGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCVDYFTTQGLTTIYQIEHYSMDDLVSLKIPEQFRHAIWKGILDHRQL-----------HDFSSP-PHLLRTP T_guttata_ENSTGUP00000009686 TGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPSDCSIVSFLARLGCSSCVDYFTTQGLTTIYQIEHYSMDDLVSLKIPEQFRHAIWKGILDHRQL-----------HDFSSP-PHLLRTP D_rerio_ENSDARP00000065136 NTDLSSLSPNNPLQSQLQMVPSSHCTPPPPYPMDNSISSFLLRLGCSACLDYFTAQGLTNIYQIENYNLEDLSRLKIPTEFQHIIWKGIMEYRQT-----------MEFSPP-PHILRTS T_nigroviridis_ENSTNIP00000014938 NGDMNGSHSNQ------TIVSASHCSPPPPYNPDPSLVSFLTSLGCQNFIEYFASQGLQSVYHLQTLSMEDLGAMKIPEQSRLAIWRALQDLKQDGPLQLPATTHHHDYHGQ--QLIRSS O_latipes_ENSORLP00000005521 NGEMNSGHSNH------NIVSASHCSPPPSYNPDPSLVSFLTSLGCQNFIEYFTSQGLQSVYHLQTLSMEDLAALKIPEQSRLVIWRGLQDMKQGVPVQLPPSAHHHDYHGQ--QLLRSS O_latipes_ENSORLP00000008029 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000001313 NGEMNGSHSSQ------SMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIEYFTSQGLQNIYHLQNLTIEDLGALKIPDQYRMTIWRGLQDLKQG-----------HDYGAQ--QLIRSS B_taurus_ENSBTAP00000020544 AGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSLVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQL-----------HDFSSP-PHLLRTP G_gorilla_ENSGGOP00000015180 NGEMSSSHSTQ------SMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMTIWRGLQDLKQG-----------HDYSTA--QQLLRS G_gorilla_ENSGGOP00000005012 AGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDXXXXXXXXXXXXXXXXXXXXXXXXX-----------XXXXXX-XXXXXXX C_intestinalis_ENSCINP00000003956 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000004447 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000002277 NGEMSSSHGAQ------SMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMTIWRGLQDLKQG-----------HDYSTA--QQLLRS A_carolinensis_ENSACAP00000000376 AGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCVDYFTAQGLTTIYQIEHYSMDDLVSLKIPEQFRHAIWKGLMDHRQL-----------HDFSSSTPHLLRTP M_domestica_ENSMODP00000008216 NGEMNGGHTSQ------SMVSGSHCTPPPPYNADPSLVSFLTGLGCPNCIEYFTSQGLQNIYHLQNLTIEDLGALKIPDQYRMTIWRGLQELKQS-----------HDYGAQ--QLIRSS O_anatinus_ENSOANP00000019815 NGEINGGHAPQ------PMVSGSHCTPPPPYNADPSLVSFLTGLGCPNCIEYFTTQGLQNIYHLQNLTLEDLGALKIPDQYRMVIWRGLQDLKQS-----------HDYGAQ--QLIRSS P_troglodytes_ENSPTRP00000000118 NGEMGSSHSAQ------SMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMTIWRGLQDLKQG-----------HDYSTT--QQLLRS A_aegypti_AAEL007594-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007595-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP002352-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0083753 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004319-PA ------------------------------------------------------------------------------------------------------------------------ 850 860 870 880 890 900 910 920 930 =========+=========+=========+=========+=========+=========+=========+=========+========== H_sapiens_ENSP00000269305 ---------------------------------------------------------------------------KLMFKTEG-PDSD-- P_troglodytes_ENSPTRP00000014836 ---------------------------------------------------------------------------KLMFKTEG-PDSD-- G_gorilla_ENSGGOP00000009561 ---------------------------------------------------------------------------KLMFKTEG-PDSD-- P_pygmaeus_ENSPPYP00000008923 ---------------------------------------------------------------------------KLMFKTEG-PDSD-- M_mulatta_ENSMMUP00000035274 ---------------------------------------------------------------------------KFMFKTEG-PDSD-- O_cuniculus_ENSOCUP00000000989 ---------------------------------------------------------------------------KPMFKREG-PDSD-- C_familiaris_ENSCAFP00000024579 ---------------------------------------------------------------------------KLMFKREG-PDSD-- M_musculus_ENSMUSP00000104298 ---------------------------------------------------------------------------KTMVKKVG-PDSD-- B_taurus_ENSBTAP00000001420 ---------------------------------------------------------------------------KPMLKREG-PDSD-- R_norvegicus_ENSRNOP00000047840 ---------------------------------------------------------------------------KPMIKKVG-PDSD-- E_caballus_ENSECAP00000006210 ---------------------------------------------------------------------------KLIFKREG-PDSD-- D_rerio_ENSDARP00000051548 ---------------------------------------------------------------------------KLMVKDEGRSDSD-- X_tropicalis_ENSXETP00000053761 ---------------------------------------------------------------------------KLLVKDEL-QDSE-- G_aculeatus_ENSGACP00000018012 ------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013035 ---------------------------------------------------------------------------RLMHRGEK-SDSD-- A_carolinensis_ENSACAP00000001746 GNASTISI----GASGELQRQRVMEAVHFRVRHTITIPNRGG----------ADEWADFGFDL--PDCK---SR-KHSIKEEF-TEGEIN T_rubripes_ENSTRUP00000008025 SGASSVSV----G-ATEARGERVIDAVRFTLRQTISFPPR-------------DEWSDFSFDL--DSRR---NK-QQRIKEEG-E----- X_tropicalis_ENSXETP00000010981 SNASTISI----GSSGELQRQRVMEAVHFRVRHTITIPNRGG----------ADEWADFGFDL--PDCK---SR-KQSIKEEY-ENSDIN T_nigroviridis_ENSTNIP00000016776 SGASSVSV----G-AAEARSERVIDAVRFTLRQTISFPPR-------------DEWSDFSFDL--DSRR---NK-QQRIKEEG-E----- C_familiaris_ENSCAFP00000028819 SNASTISI----GSSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGSG----PDEWADFGFDL--PDCK---SR-KQSIKEEF-TESEIN H_sapiens_ENSP00000367545 SNAATISI----GGSGELQRQRVMEAVHFRVRHTITIPNRGGPGG--G----PDEWADFGFDL--PDCK---AR-KQPIKEEF-TEAEIH C_familiaris_ENSCAFP00000020585 SGASTVSV----G-SSETRGERVIDAVRFTLRQTISFPPR-------------DEWNDFNFDM--DARR---NK-QQRIKEEG-E----- T_rubripes_ENSTRUP00000030645 ---------------------------------------------------------------------------RLLHRGEK-SDSD-- B_taurus_ENSBTAP00000007643 SNAATIAI----GGSGELQRQRVMEAVHFRVRHTITIPNRGGPAGGAG----PDEWADFGFDL--PDCK---SR-KQSIKEEF-TESEAN O_latipes_ENSORLP00000019616 SGASTVSV----G-AAEARGERVIDAVRFTLRQTISFPPR-------------DEWSDFSFDL--DSTK---SR-EQEFKQSN-S----- M_mulatta_ENSMMUP00000021768 SNAAAISI----GGSGELQRQRVMEAVHFRVRHTITIPNRGGPGA--G----PDEWADFGFDL--PDCK---AR-KQPIKEEF-TEAEIH M_musculus_ENSMUSP00000101269 SNAATISI----GGSGELQRQRVMEAVHFRVRHTITIPNRGGAGAVTG----PDEWADFGFDL--PDCK---SR-KQPIKEEF-TETESH R_norvegicus_ENSRNOP00000052265 SNAATISI----GGSGELQRQRVMEAVHFRVRHTITIPNRGGAGGVTG----PDEWADFGFDL--PDCK---SR-KQPIKEEF-TETESH G_gallus_ENSGALP00000001485 SNASTISI----GSSGELQRQRVMEAVHFRVRHTITIPNRGA----------ADEWADFGFDL--PDCK---SR-KQSIKEEF-TEGEIN G_aculeatus_ENSGACP00000008676 SNMTASAMAAIGAASGELQRQRVMEAVHFRVRHTITIPNRPGVVGTSGMAATNDEWADFGFDM--PDCKLSRSS-RHSIKEEF-MESDVH O_anatinus_ENSOANP00000021753 SGASTVSV----G-SSETRGERVIDAVRFTLRQTISFPPR-------------DEWNDFNFDM--DARR---NK-QQRIKEEG-E----- M_mulatta_ENSMMUP00000021634 SSASTVSV----G-SSETRGERVIDAVRFTLRQTISFPPR-------------DEWNDFNFDM--DARR---NK-QQRIKEEG-E----- P_pygmaeus_ENSPPYP00000016106 SSASTVSV----G-SSETRGERVIDAVRFTLRQTISFPPR-------------DEWNDFNFDM--DARR---NK-QQRIKEEG-E----- D_rerio_ENSDARP00000074096 SNMATMAI----GPSGELQRQRVMEAVHFRVRHTITIPNRGPANG-------PEEWPDFGFDM--PDCR---LH-KHSIKEEF-AEGDVH H_sapiens_ENSP00000264731 SSASTVSV----G-SSETRGERVIDAVRFTLRQTISFPPR-------------DEWNDFNFDM--DARR---NK-QQRIKEEG-E----- P_troglodytes_ENSPTRP00000027067 SSASTVSV----G-SSETRGERVIDAVRFTLRQTISFPPR-------------DEWNDFNFDM--DARR---NK-QQRIKEEG-E----- R_norvegicus_ENSRNOP00000033463 SGASTVSV----G-SSETRGERVIDAVRFTLRQTISFPPR-------------DEWNDFNFDM--DSRR---NK-QQRIKEEG-E----- M_musculus_ENSMUSP00000110965 SGASTVSV----G-SSETRGERVIDAVRFTLRQTISFPPR-------------DEWNDFNFDM--DSRR---NK-QQRIKEEG-E----- O_cuniculus_ENSOCUP00000014157 XXXXXXXX----X-XXXXXXXXXXXXXXXXXXXXXXXXPR-------------DEWNDFNFDM--DARR---NK-QQRIKEEG-E----- E_caballus_ENSECAP00000016315 SGASTVSV----G-SSETRGERVIDAVRFTLRQTISFPPR-------------DEWNDFNFDM--DARR---NK-QQRIKEEG-E----- T_rubripes_ENSTRUP00000038165 SNMTSSAMAAIGGPGGELQRQRVMEAVHFRVRHTITIPHRPGVVGTSGMTAAADEWADFGFDM--PDCKLS-CS-KHSIKEEF-MESDVH M_domestica_ENSMODP00000018831 SGSSTVSV----G-SSETRGERVIDAVRFTLRQTISFPPR-------------DDWNDFNFDM--DARR---NK-QQRIKEEG-E----- G_aculeatus_ENSGACP00000025614 ---------------------------------------------------------------------------RLLR-----SDSE-- T_guttata_ENSTGUP00000002829 SNASTISI----GSSGELQRQRVMEAVHFRVRHTITIPNRGA----------ADDWADFGFDL--PDCK---SR-KQSIKEEF-TEGEIN G_gallus_ENSGALP00000011836 SGASTVSV----G-SSETRGERVIDAVRFTLRQTISFPPR-------------DEWNDFNFDM--DARR---NK-QQRIKEEG-E----- T_guttata_ENSTGUP00000009686 SGASTVSV----G-SSETRGERVIDAVRFTLRQTISFPPR-------------DEWNDFNFDM--DARR---NK-QQRIKEEG-E----- D_rerio_ENSDARP00000065136 SGTSTVSV----G-STEARGERVIDAVRFTLRQTISFPPR-------------DDWTDFSFDLAPDSRR---NK-QQRIKEEG-E----- T_nigroviridis_ENSTNIP00000014938 SNMTASAMAAIGGPGGELQRQRVMEAVHFRVRHTITIPHRSGAVGTSGMAAAADEWADFGFDM--PDCKLS-CS-KHSIKEEF-MESDVH O_latipes_ENSORLP00000005521 GNMAASAMAAIGSSGGELQRQRVMEAVHFRVRHTITIPNRSG-VGTAGMAAAADEWADFGFDM--PDCKVS-RN-KHSIKEEF-MESDVH O_latipes_ENSORLP00000008029 ---------------------------------------------------------------------------AMRTKEEQ-SDQT-- E_caballus_ENSECAP00000001313 SNASTISI----GSSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGSG----PDEWADFGFDL--PDCK---SR-KQSIKEEF-TES--- B_taurus_ENSBTAP00000020544 SGASTVSV----G-SSETRGERVIDAVRFTLRQTISFPPR-------------DEWNDFNFDM--DARR---NK-QQRIKEEG-EEGEIR G_gorilla_ENSGGOP00000015180 SNSATISI----GGSGELQRQRVMEAVHFRVRHTITIPNRGGPGG--G----PDEWADFGFDL--PDCK---AR-KQPIKEEF-TEAEIH G_gorilla_ENSGGOP00000005012 XXXXXXXX----X-XXXXXXXXXXXAVRFTLRQTISFPPR-------------DEWNDFNFDM--DARR---NK-QQRIKEEG-E----- C_intestinalis_ENSCINP00000003956 ---------------------------------------------------------------------------QIMTSDLLSQVGYQE C_intestinalis_ENSCINP00000004447 ------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000002277 SNAATISI----GGSGELQRQRVMEAVHFRVRHTITIPNRGGPGG--G----PEEWADFGFDL--PDCK---AR-KQPIKEEF-TEAEIH A_carolinensis_ENSACAP00000000376 SGASTVSV----G-SSETRGERVIDAVRFTLRQTISFPPR-------------DEWNDFNFDL--DARR---NKQQQRIKEEG-E----- M_domestica_ENSMODP00000008216 SNASTISI----GSSGELQRQRVMEAVHFRVRHTITIPNRSG----------ADEWADFGFDL--PDCK---SR-KQSIKEEF-TDSEIN O_anatinus_ENSOANP00000019815 SNASTISI----GSSGELQRQRVMEAVHFRVRHTITIPNRGG-----G----ADDWADFGFDL--PDCK---SR-KQSIKEEF-TEGEIN P_troglodytes_ENSPTRP00000000118 SNAATISI----GGSGELQRQRVMEAVHFRVRHTITIPNRGGPGG--G----PDEWADFGFDL--PDCK---AR-KQPIKEEF-TEAEIH A_aegypti_AAEL007594-PA ------------------------------------------------------------------------------------------ A_aegypti_AAEL007595-PA ------------------------------------------------------------------------------------SSVDSD A_gambiae_AGAP002352-PA ------------------------------------------------------------------------------------------ D_melanogaster_FBpp0083753 ------------------------------------------------------------------------------------------ A_gambiae_AGAP004319-PA ------------------------------------------------------------------------------------CSVDLL