10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000276431 M-------------------------------------------------------EQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVV--AAVLL-LVSAESALITQQDLA P_troglodytes_ENSPTRP00000034375 M-------------------------------------------------------EQRGQNAPAASGARKRHGPGPREARGARPGLRVPKTLVLIV--AAVLL-LVSAESALITQQDLA P_pygmaeus_ENSPPYP00000020655 M-------------------------------------------------------EQRGQNAPAASGARKRRGPGPREVRGAGPGLRVPKTLVLVV--AAVLL-LVSAESALITQQDLV G_gorilla_ENSGGOP00000010773 M-------------------------------------------------------EQRGQNAPAASGARKRHGPGPREARGARPGLRVPKTLVLVV--VAVLL-LVSAESALITQEDLA P_pygmaeus_ENSPPYP00000020658 MAPPPAGIKLGAFLAVTPNPGSAESETEAAAATPSKVWSSSAGRTEPRGGGRGALPTPMGQHGPSAR-ARAGRAPGPRPARGASPRLRVHKTFKFVV--VGVLLQVVPSSAATIKLHD-- P_troglodytes_ENSPTRP00000034378 MAPPPAGVNLGAFLAVTPNPGSAASGTEAAAATPSKVWGSSAGRIEPRGGGREALPTSMGQHGPSAR-ARAGRAPGPRPAREASPRLRVHKTFKFVV--VGVLLQVVPSSAATIKLHD-- H_sapiens_ENSP00000221132 MAPPPARVHLGAFLAVTPNPGSAASGTEAAAATPSKVWGSSAGRIEPRGGGRGALPTSMGQHGPSAR-ARAGRAPGPRPAREASPRLRVHKTFKFVV--VGVLLQVVPSSAATIKLHD-- G_gorilla_ENSGGOP00000002136 MAPPPAGIKLGAFLAVTPNPGSAASGTEAAAATPSKVWGSSAGRIEARGGGRGALPTPMGQHGPSAR-ARAGRAPGHRPAREAIPRLRVHKTFKFVV--VGVLLQVVPSSAATIKLHD-- E_caballus_ENSECAP00000022015 ------------------------------------MTLPGVTQRRPELGALPNPAGQRGPSALAASGAPAGCAPGPRPAPG-------PRTLIFV---LGTLL-LGPAASAMIIRQERV M_mulatta_ENSMMUP00000021894 ---------------------------------------------------------------------------------------------------------VVPGSAATIKVHD-- M_mulatta_ENSMMUP00000009898 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021892 -------------------------------------------------------MGLCGQSAPTASSARAGRSPGARTASGTTPWLPDPKTLKFVFVVVAVLL-PAQVDSATISRKDEV P_pygmaeus_ENSPPYP00000020657 -------------------------------------------------------LGLWEQSALTTMRAPVGRYLAARTASGTRPWLPGPKTLKFVVLIVAVLL-PVYVYSATIPRQDEA H_sapiens_ENSP00000310263 -------------------------------------------------------MGLWGQSVPTASSARAGRYPGARTASGTRPWLLDPKILKFVVFIVAVLL-PVRVDSATIPRQDEV G_gorilla_ENSGGOP00000007840 -------------------------------------------------------MGLWGQSVPTASSARAERYPGARTASGTRPWLLDPKTLKFVVFIVAVLL-PVRVVSATIPRQDEV P_troglodytes_ENSPTRP00000034377 -------------------------------------------------------MGLWGQSVPTASSARAERYPGARTASGTRPWLLDPKTLKFVVFIVAVLL-PVRVDSATIPGQDEV M_musculus_ENSMUSP00000022663 ------------------------------------------------------------MEPPGPSTPTASAAARADHYTPGLRPLPKRRLLYSFALLLAVLQAVF-----VPVTANPA P_troglodytes_ENSPTRP00000034372 -------------------------------------------------------MRLWGQSAPTASSVGAGRYPGARTASGTRRRLPGPKTLKFLVF-VAVLP-RVQVDSATIRPQDEA G_gorilla_ENSGGOP00000010787 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000349324 ---------------------------------------------MQGVKERFLPLGNSGDRAPRPPDGRGRVRPRTQDGVGNHTMARIPKTLKFVVVIVAVLL-PVLAYSATTARQEEV P_troglodytes_ENSPTRP00000034376 ---------------------------------------------MQGVKERFLPLGNSGDRAPRPPDGRGRVRPRTQDGVGNHTVARIPNTLKFVVVIVAVLL-PVLAYSATTARQEEV G_gallus_ENSGALP00000000612 ----------------------------------------------------------------------------------------LRTPLGQCPLLVPLFAEVQLGSAA-------- R_norvegicus_ENSRNOP00000055444 ------------------------------------------------------------------------------------------------------------QSFFVPVTAKLA M_domestica_ENSMODP00000011508 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020656 ---------------------------------------------------------------------------------------------KSLTPITPLSP-QVLAYSATTARQEEV G_gorilla_ENSGGOP00000010781 ---------------------------------------------MQGVKERFLPLGNSGDRAPRPPDGRGRVRPRTQDGVGNHTVARIPKTLKFVVVIVAVLL-PVLAYSATTARQEEV O_latipes_ENSORLP00000003602 -----------------------------------------------------------------------------------------------STQVVALFAGLVCHAAEPPASQRSA O_anatinus_ENSOANP00000021880 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000001044 --------------------------------------------------------------------------------------------QMIQVLLLAVVCGLKSGAVEPPASQWSR T_rubripes_ENSTRUP00000013812 -------------------------------------------------------------------------------------------SQMIQVLLLAVLCGLQCGAVEPPASQWSR G_gallus_ENSGALP00000038567 ------------------------------------------------------------------------------------------MGLRAVGLLLLVTLLTVPGSDA-------- T_rubripes_ENSTRUP00000010129 ------------------------------------------------------------------------------------------------FQVLSLLIWLLTPTEAPPQSNLSL G_aculeatus_ENSGACP00000007142 -----------------------------------------------------------------------------------------MVSVKSVFCILIVFLKPSGAFPQ-------- D_rerio_ENSDARP00000012354 --------------------------------------------------------------------------------------------MRYITLLVLLLLNVINAARSHGDLAWAH D_rerio_ENSDARP00000010724 ------------------------------------------------------------------------------------LKTSNVCQTCFKALVIFSLALVGHGAAELGVSA--- G_gallus_ENSGALP00000023975 ------------------------------------------------------------------------------------MRGLALPRSSLGTVILTFVCVLVEESVGIAPVPYML O_latipes_ENSORLP00000020293 ---------------------------------------------------------------------------------------------------ITLILQTTKSQVVKLTAANLP G_aculeatus_ENSGACP00000020911 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000005522 ------------------------------------------------------------------------------------MGLPTVPGLLLPLVLPALLADVYPAGVQ-----GLV T_rubripes_ENSTRUP00000011080 -------------------------------------------------------------------------------------MERGAFSRRDTTPLPTVLLLLCLVTPTLT------ T_guttata_ENSTGUP00000013762 ------------------------------------------------------------------------------------MRSPALPRTSLRTVILIFVCVLTKESVEITPVPYRL O_anatinus_ENSOANP00000007822 -------------------------------------------------------------------------SRNLAQGSQSACFLLLFPQWAFGTFVLAVTFPMGSNNPP-------- G_aculeatus_ENSGACP00000013477 ---------------------------------------------------------------------------------LSVCYLTSGTFIVFSVFQCMSIPTLTLSEPPEE------ M_domestica_ENSMODP00000022511 --------------------------------------------------------------------------------------MGCFFCLIFLQVALALMVGLYFHVAS-------- G_aculeatus_ENSGACP00000011439 --------------------------------------------------------------------------------------------LEVVCLVDLTVICLLQVTPG-------- C_familiaris_ENSCAFP00000022390 ---------------------------------------------------------------------------------MRLPWAASPCGLAWGPLIVGLCGLLAASQAR-------- P_troglodytes_ENSPTRP00000007808 ------------------------------------------------------------------------------------MGLSTVPDLLLPLVLLELLVGIYPSGVI-----GLV M_domestica_ENSMODP00000031142 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000022515 ---------------------------------------------------------------------------------MRLPQACSLQGLLRGPLLLGLFGLLAGQQLR-----QPI M_mulatta_ENSMMUP00000021657 -----------------------------------------------------------MSARAAETHRSARPAAASKRLRFPGTTMNKLLCCALVFLDISIKWTTQETFPP-------- E_caballus_ENSECAP00000014162 ------------------------------------------------------------------------------------MGLPAVPGLLPPLALLALLVEIYPSGVT-----GLV 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000276431 P------------------------QQRAAPQQKRSSPSEGLCP--PGHH------ISEDGRDCISCKYGQDYSTHWN-DLLFCLRCTR-CD-S-------GEVELSPCTTTRNTVCQCE P_troglodytes_ENSPTRP00000034375 P------------------------QQRAAPQQKRSSPSEGLCP--PGHH------ISEDSRDCISCKYGQDYSTHWN-DLLFCLRCTR-CD-S-------GEVEVSPCTTTRNTACQCE P_pygmaeus_ENSPPYP00000020655 P------------------------QQRAAPQQKRSSPSEGL------HH------ISEDSRDCISCKYGQDYSTHWN-DLLFCLRCTK-CD-S-------GEVEVSPCTTTRNTVCQCE G_gorilla_ENSGGOP00000010773 P------------------------QQRAAPQQKRSSPSEGLCP--PGHH------ISEDGRDCISCKYGQDYSTHWN-DLLFCLRCTR-CD-S-------GEVEVSPCTTTRNTVCQCE P_pygmaeus_ENSPPYP00000020658 --------------------------QSVGTQQWEHSPLGELCP--PGSH------RSEHPGACNRCTEGVGYTNASN-NLFACLPCTA-CK-S-------DEEERSPCTTTRNTACQCK P_troglodytes_ENSPTRP00000034378 --------------------------QSIGTQQWEHSPLGELCP--PGSH------RSEHPGACNQCTEGVGYTNASN-NLFACLPCTA-CK-S-------DEEERSPCTTTSNTACQCK H_sapiens_ENSP00000221132 --------------------------QSIGTQQWEHSPLGELCP--PGSH------RSEHPGACNRCTEGVGYTNASN-NLFACLPCTA-CK-S-------DEEERSPCTTTRNTACQCK G_gorilla_ENSGGOP00000002136 --------------------------QSIGTQQWEHSPLGELCP--PGSH------RSEHPGACNRCTEGVGYTNASN-NLFACLPCTA-CK-S-------DEEERSPCTTTRNTACQCK E_caballus_ENSECAP00000022015 H------------------------QQLAAPQ------MSTKCP--AGYH------VSEDSRSCTPCTDGVDYTSHKN-LFSSCLPCST-CK-S-------DEERIADCTRTEDTQCRCK M_mulatta_ENSMMUP00000021894 --------------------------QSVGTQQWEHSPLGELCP--PGSH------RSEDSGACNQCTEGVGYTSASN-NLFSCLPCTA-CK-S-------DEEERSACTRTRNTACQCK M_mulatta_ENSMMUP00000009898 -----------------------------------------------GHH------ISEDSRECISCKYGQDYSTHWN-DFLFCLRCTK-CD-S-------GEVEVNSCTTTRNTVCQCE M_mulatta_ENSMMUP00000021892 P------------------------LPPVASKQQRRSL-EAECP--AGFH------RSEHTGACNPCTEGVDYTIASN-NLPSCLLCTV-CK-S-------GQTNTSSCTTTRDTVCQCE P_pygmaeus_ENSPPYP00000020657 P------------------------QQTVAPQQQRRSLKEEECP--AGSH------RSEHTGACNPCTEGVDYTIASN-NLPSCLLCTV-CK-S-------GQTTKSSCTTTRDTMCQCE H_sapiens_ENSP00000310263 P------------------------QQTVAPQQQRRSLKEEECP--AGSH------RSEYTGACNPCTEGVDYTIASN-NLPSCLLCTV-CK-S-------GQTNKSSCTTTRDTVCQCE G_gorilla_ENSGGOP00000007840 P------------------------QQTVAPQQQRRSLKEEECP--AGSH------RSEYTGACNPCTEGVDYTIASN-NLPSCLPCTV-CK-S-------GQTNKSSCTTTRDTVCECE P_troglodytes_ENSPTRP00000034377 P------------------------QQTVAPQQQRRSLKEEECP--AGSH------RSEYTGACNPCTEGVDYTIASN-NLPSCLPCTV-CK-S-------GQTNKSSCTTTRDTVCQCE M_musculus_ENSMUSP00000022663 H------------------------NRPAGLQRPEESPSRGPCL--AGQYL--------SEGNCKPCREGIDYTSHSNHSLDSCILCTV-CK-E-------DKVVETRCNITTNTVCRCK P_troglodytes_ENSPTRP00000034372 P------------------------QQTAAPQEERRSLKEKKCP--A-SH-----------RACNPCREGVDYTNASN-NAPSCFPCTV-CK-S--------EKEMSPCTTTRNTVCQCE G_gorilla_ENSGGOP00000010787 ------------------------------------------------SH------RSEHTGACNPCXEGVDYTNASX-NXPSCFPCTV-CK---------XEKEMSPCTTTGNTVCQCE H_sapiens_ENSP00000349324 P------------------------QQTVAPQQQRHSFKGEECP--AGSH------RSEHTGACNPCTEGVDYTNASN-NEPSCFPCTV-CK-S-------DQKHKSSCTMTRDTVCQCK P_troglodytes_ENSPTRP00000034376 P------------------------QQTVAPQQQRHSFEGEECP--AGSH------RSEHTGACNLCTEGVDYTNASN-NEPSCFPCTV-CK-S-------DQKHKSSCTMTRDTVCQCK G_gallus_ENSGALP00000000612 ----------------------AVKKRADRSDLQKPDLYRRKCP--MGTY------EANDSIQCLPCKKD-EYTEYPN-DFPKCLGCRT-CR-E-------DQVEVSPCIPTRNTQCACK R_norvegicus_ENSRNOP00000055444 Q------------------------DRPADLQRLKQSP--LECPAVSGQY------LSKEDGSCKACIDGENYTSGPN-VLPSCLSCRV-CK-EGLSHVVNRKYPSVRCART----CHIW M_domestica_ENSMODP00000011508 --------------------------------------------------------------------------------------------------------ETVPCHATHNTKCQCR P_pygmaeus_ENSPPYP00000020656 P------------------------QQTVTPQQQRHSFKGEECP--AGSH------RSEHTGACNPCTEGVDYTNASN-NLFSCLPCTV-CK-S-------DQKNKSSCIMTRDTVCQCE G_gorilla_ENSGGOP00000010781 P------------------------XQTVAPQQQRHSFKGEECP--AXXX------XXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXX-XX-X-------XQKHKSSCTMTRDTVCQCK O_latipes_ENSORLP00000003602 G------------VHRNATLRQHQAQCVENQQYPHQGLCCLNCQAVAGTFVKKPCERDQQQGICEPCEHGQTHTEHSN-GMGRCLPCNH-CR-Q-------DQIEVAACTVTTNTRCQCK O_anatinus_ENSOANP00000021880 ----------------------------------------LHFP--SGQYVKEGCNTSFTHGICAPCQNGANFTAFPN-GLFYCIKCQI-CK-P-------DQEEVSPCTTTEDTQCHCK T_nigroviridis_ENSTNIP00000001044 N------------EFQNLTLRQHR-TCVENEQYYYQGLCCLNCQ--AGTFVHKGCDRDQERGLCLPCEHGQTYTEHSN-GMHGCLPCTR-CR-T-------DEIETASCTTTSDTRCQCK T_rubripes_ENSTRUP00000013812 K------------EHQNLTVRQHR-NCVENEQYLHQGFCCLNCR--AGTFVYKECERDQEQGVCHSCEHGQTYTEHSN-GMNRCLPCTH-CR-L-------DEIETASCTTTSDTRCQCK G_gallus_ENSGALP00000038567 -------------------------EVCGEGEYLYEDICCMLCP--AGTYVAQHCRIPHSRGKCASCTEGRDYTAHAN-GLEECLLCRQ-CK-D-------DQITLRTCTVTSDTECQCH T_rubripes_ENSTRUP00000010129 --------------IGGRMRREV--NCRDQQEYRSGGICCLNCP--AGTYVTSPCRTSGQQGVCQECDDG-TYMEHTN-GLSQCFRCTQ-CR-S-------DQEVLRQCAHTHNTECRCR G_aculeatus_ENSGACP00000007142 -------------------------PKCKDGLENTNGVCCSKCP--AGKRQASPCTQHGEEGKCEECDDG-TFIEHAN-VLHHCLKCTQ-CRPE-------DQEVVRQCTHTQDGECQCK D_rerio_ENSDARP00000012354 R------------SVKNRLSRDV--SCREGLEYPHENICCLNCP--AGTYVKKACAAAAEKGVCAPCEFD-TYTEHDH-GLLKCISCDK-CR-I-------DQETIEKCTSTQNTRCKCR D_rerio_ENSDARP00000010724 -------------DHQNRTARQM--TCLENHEYPHNGFCCKNCE--AGTYVKEKCTSGQVMGKCSPCEKG-TYAEHPT-GMEQCLQCSQ-CH-R-------DQTVVAECTSTSNTKCDCK G_gallus_ENSGALP00000023975 QLRRATLDGRDPFNRLRREKRQVQCQLGQYLH-PKGTHCCMRCH--AGTYKLKDCEWSGQAPVCLPCPNG-TFTAVDN-IMEKCFQCTR-CRTEL------QQIEKTPCTQKQDTVCGCR O_latipes_ENSORLP00000020293 P------------GLRVRRRRHF--GACGEQEYPNGNICCLNCK--AGTFVKSSCTAAGQRGTCEECDYG-TFTEHDN-HLQKCVDCAK-CG-P-------DQEVAEQCTNTQNTKCRCK G_aculeatus_ENSGACP00000020911 ----------------------------------------------AGTFVHKGCERDQESGSCVACEDGRAYTEHSN-GMSRCLPCTH-CR-S-------DEIRTASCTTTTDTSCQCR B_taurus_ENSBTAP00000005522 P------------HPGDLEKRESPCPQGKYNHPQNSTICCTKCH--KGTYLYNDCPGPGRDTDCRVCAPG-TYTALEN-HLRRCLSCSR-CRDEM------FQVEISPCVVDRDTVCGCR T_rubripes_ENSTRUP00000011080 -------------------------SCLDVEYQSESGICCNKCP--PGYRLKEECSAPRERSNCTACPYG-QYMDTMN-YADKCRTCRK-CNTPD------HKVVFRPCKGNQNTVCQCD T_guttata_ENSTGUP00000013762 QVRQVALDGRDPSNPLRREKKQMHCQLGQYLH-PRKTHCCMRCH--AGTYKAKDCDGPDQATVCLPCSNG-TFTAVDN-TMSKCFQCKR-CRTAL------QQIVETPCTPKQDTVCGCQ O_anatinus_ENSOANP00000007822 -------------------------TYSWKDSTTQERLQCQQCP--PGTYVSQHC-SRTSPTQCQPCPTL-HYTQYWN-YLDKCRYCNVFCG-A-------QEEEVHPCSATHNRVCQCQ G_aculeatus_ENSGACP00000013477 -------------------------LCPHGDYETDKGICCNKCS--RGQKLLEDCNAKGQRSKCVTCPDK-EYTDQEN-YSPNCNRCGT-CKVSK------NEVTVSACQKTQNTVCRCK M_domestica_ENSMODP00000022511 -------------GMSIQKRHQENCPEGKYEHRTNASICCLKCH--KGTYLNADCGDSGLAPDCKTCPNG-TFTEREN-YVSKCLSCSI-CRKEM------GQIEKTPCTISRNTVCGCG G_aculeatus_ENSGACP00000011439 -------------------------EACASGQLTESGQCCSLCP--AGFEMKVDC--GKEDTKCTQCPKG-TFSSSE--GLGPCLPCAK-CP-R-------SVPTVASCSATQDTQCECD C_familiaris_ENSCAFP00000022390 P------------DLPYHTENQTCQDREKEYYEPKHQVCCSRCP--PGTHVSVEC-SRSQDTVCAMCPEN-SYNEHWN-HLSICQLCRP-CDQML------GFEETVPCTSRQKTQCRCQ P_troglodytes_ENSPTRP00000007808 P------------HLGDREKRDSVCPQGKYIHPQNNSICCTKCH--KGTYLYNDCPGPGQDTDCRECESG-SFTASEN-HLRHCLSCSK-CRKEM------GQVEISSCTVDRDTVCGCR M_domestica_ENSMODP00000031142 ------------------------------FVDKSSSLCCRSCP--AGHFLKAPCTESQGSSFCQPCHED-TFLSREDHNEKRCSRCQA-CDENGPA----NQVVVRNCSTVANTQCGCA M_domestica_ENSMODP00000022515 L------------SPPQGPPDTKCAD--QQYYEPRHEVCCSRCP--PGMHVLEFC-NRHRNTTCAPCPPR-SYNEFWN-HINVCQLCRP-CDKVL------GFEEVAPCNASRKTQCRCR M_mulatta_ENSMMUP00000021657 -------------------------KYLHYDQETSHQLLCDKCP--PGTYLKQHC-TAKWKTVCAPCPDH-YYTDSWH-TSDECLYCSPVCK-E-------LQYVKQECNRTHNRVCECK E_caballus_ENSECAP00000014162 P------------PLRDREKRDSLCPQGKYSHPQNNSICCTKCH--KGTYLHNDCLGPGLDTDCRECENG-TFTASEN-HLRQCLSCSK-CRKEM------NQVEISSCTVDRDTVCGCR 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000276431 EGTFRE---E----DSP-EMCRKCRTGCPRGMV-KVGDCTPWSDIECVHKESGTKHSGEVP------------------------------------------------------AVEET P_troglodytes_ENSPTRP00000034375 EGTFRE---E----DSP-EMCRKCRTRCPRGMV-KVGDCTPWSDIECVHKESGTKHTGEAP------------------------------------------------------AVEET P_pygmaeus_ENSPPYP00000020655 EGTFRE---E----DSP-EMCRKCRTGCPRGMA-KVGDCTPWSDIECVHKE--------------------------------------------------------------------- G_gorilla_ENSGGOP00000010773 EGTFRE---E----DSP-EMCRKCRTGCPRGMV-KVGDCTPWSDIECVHKESGTKHTGEAP------------------------------------------------------AVEET P_pygmaeus_ENSPPYP00000020658 PGTFRN---D----NSA-EMCRKCSTGCPRGMV-KVGDCTPWSDIECVHKESGNGHN--------------------------------------------------------------- P_troglodytes_ENSPTRP00000034378 PGTFRN---D----NSA-EMCRKCSTGCPRGMV-KVKDCTPWSDIECVHKESGNGHN--------------------------------------------------------------- H_sapiens_ENSP00000221132 PGTFRN---D----NSA-EMCRKCSRGCPRGMV-KVKDCTPWSDIECVHKESGNGHN--------------------------------------------------------------- G_gorilla_ENSGGOP00000002136 PGTFRN---D----NSA-EMCRKCSTGCPRGMV-KVKDCTPWSDIECVHKESGNGHN--------------------------------------------------------------- E_caballus_ENSECAP00000022015 RGTFHG---E----DFP-EVCQTCRSRCPDGMV-EAGPCTPWSDLKCVHQGSGTQASGEAP------------------------------------------------------VPGEP M_mulatta_ENSMMUP00000021894 PGTFRN---D----DSA-EMCRKCSTGCPRGKV-KVKDCTPWSDIECVHNESGNGHN--------------------------------------------------------------- M_mulatta_ENSMMUP00000009898 EGTFRE---E----DSP-EICRKCRTGCPRGMV-KVKDCTPWSDIECVHKESGTKHTGEVP------------------------------------------------------AVEKT M_mulatta_ENSMMUP00000021892 KGSFQD---A----NSP-EMCRKCSTGCPRGMI-KVSDCTPWSDINC-SA-SAASSTGKTP------------------------------------------------------AAEDT P_pygmaeus_ENSPPYP00000020657 KGSFQD---E----NTP-EMCQKCRTGCPRGMV-KVRNCTSQSDIKCKNE-SAASSTGKTP------------------------------------------------------AAEDT H_sapiens_ENSP00000310263 KGSFQD---K----NSP-EMCRTCRTGCPRGMV-KVSNCTPRSDIKCKNE-SAASSTGKTP------------------------------------------------------AAEET G_gorilla_ENSGGOP00000007840 KGRFQD---K----NSP-EMCRKCRTGCPRGMV-KVSNCTSQSDIKCKNE-SAASSTGKTP------------------------------------------------------AAEET P_troglodytes_ENSPTRP00000034377 KGRFQD---K----NSP-EMCRTCRTGCPRGMV-KVSNCTSQSDIKCKNE-SAASSTGKTP------------------------------------------------------AAEET M_musculus_ENSMUSP00000022663 PGTFED---K----DSP-EICQSCSN-CTDGEE-ELTSCTPRENRKCVSKTAW------------------------------------------------------------------- P_troglodytes_ENSPTRP00000034372 PGSFWN--------DST-EMCRKCRTECPRGME-KVSDCTPLSDINCKNE-SAASSTGKTP------------------------------------------------------AAEET G_gorilla_ENSGGOP00000010787 PGSFWN--------NST-EMCRKCRTECPRRME-KVSDCTXWSDIXCKNE-SAASSTGKTP------------------------------------------------------AAEET H_sapiens_ENSP00000349324 EGTFRN---E----NSP-EMCRKCSR-CPSGEV-QVSNCTSWDDIQCVEE-FGANATVETP------------------------------------------------------AAEET P_troglodytes_ENSPTRP00000034376 EGTFRN---E----NSP-EMCRKCSR-CPSGEV-QVSNCTSWDDIQCVEE-FGASATVETP------------------------------------------------------AAEET G_gallus_ENSGALP00000000612 NGTFCL---P----DHPCEMCQKCQTECPKGQV-RLAPCTQHSDLLCGPPLEISSS---------------------------------------------------------------- R_norvegicus_ENSRNOP00000055444 SAAF----------SQNLIICFLCVPSCTDGED-EVIPCTPKANRKCVPKNTQ------------------------------------------------------------------- M_domestica_ENSMODP00000011508 SGTFCP---K----EHPCEICRKCTSECPREMV-EKNPCSPSSDLECQEPTGTPTGHR---------------------------------------------------------DGCQE P_pygmaeus_ENSPPYP00000020656 EGTFWN---E----NSP-EMCRKCSR-CPSGEV-QVSNCTSWDDIQCVEE-FGANATVETP------------------------------------------------------AAEET G_gorilla_ENSGGOP00000010781 EGTFRN---E----NSP-EMCRKCSR-CPSGEV-QVSNCTSWDDIQCVEE-FGANATVETP------------------------------------------------------AAEET O_latipes_ENSORLP00000003602 PGTFCA---P----EQACEVCKRCAKRCKAGEE-EVKKCTPFSNTVCQKRGPSSTEPAPVR------------------------------------------------------PSPTS O_anatinus_ENSOANP00000021880 AGTFCP---R----DHPCEVCMKCKTRCPEDMA-VGSSCQPWSDLQCVPSERTVPRQ--------------------------------------------------------------- T_nigroviridis_ENSTNIP00000001044 LGTFCV---P----DQACEVCKRCAK-CKAGEE-EVEKCTPSSNTVCRKRDPSPVEPSQ--------------------------------------------------------ASPTP T_rubripes_ENSTRUP00000013812 PGTFCV---P----DQACEVCKRCAK-CKAGEE-EVKKCTPSSNTECRKHNL-------------------------------------------------------------------P G_gallus_ENSGALP00000038567 QGYFCP--------AEGCEICQRCTETCPEGRE-IVQICNATMDLGCGLPDQGNKY---------------------------------------------------------------- T_rubripes_ENSTRUP00000010129 PGRFCD---P----DQACELCKRCSR-CGQDEE-TVRNCTPTANTECKKV------------------------------------------------------------------RSSS G_aculeatus_ENSGACP00000007142 AGGFCA---P----DQPCEVCRKCSR-CKKDEV-MVRNCTATSNTECKKG------------------------------------------------------------------QLDA D_rerio_ENSDARP00000012354 NGSFCL---P----DQACEVCKKCSR-CKEDEE-TEKSCTAISNTVCRKR------------------------------------------------------------------SSPG D_rerio_ENSDARP00000010724 IGTFCL---P----DEPCEVCKKCTK-CKADEE-EVSGCTPTSNTKCRRRPSHPTEGPT--------------------------------------------------------EKPSA G_gallus_ENSGALP00000023975 KNQYQF---G----EADFFQCKNCSS-CANGII---TNCSKNSDAVC-RCKPMFFMTLNNVCKHCNSCVG---------------------------------------------EECLQ O_latipes_ENSORLP00000020293 AGRFCN---P----EEACEVCRKCLT-CKSDEE-IVRNCTFTSNTVCKKIPLKPGS---------------------------------------------------------------- G_aculeatus_ENSGACP00000020911 QGTFCV---P----DQACEVCKRCAK-CKSGEE-EVKKCTPISNTECRKRDLSPTTSVT--------------------------------------------------------DAKAS B_taurus_ENSBTAP00000005522 KNQYRE---YW---GETGFRCLNCSL-CPNGTV--NIPCQERQDTIC-HCHMGFFLK-GAKCISCHDC-KNK-------------------------------------------ECEKL T_rubripes_ENSTRUP00000011080 KGYYRS---NI---DSENFECLKCRQ-CDHPEK-ESQKCTPENNTVC-QCEDNYYRL-NNKCELCSKCVDLCSG-----------------------------------------ECKSN T_guttata_ENSTGUP00000013762 KNQYQI---DS---DSEYFQCRNCSS-CADGTI---ASCSKNKDAIC-RCKPQFFLSRNNICKPCNSCTG---------------------------------------------EDCLL O_anatinus_ENSOANP00000007822 PGYYAY-----------MDFCIEHST-CPLGSG-VVSQGTPTKNTECQECPRGTFSDNSSRTEPCQSHQNCTLLGMKVNV-----------------------------------PGNRF G_aculeatus_ENSGACP00000013477 DGYYKK---AI---DSEAYECLRCTS-CGEKEK-EKRTCTPEKNTEC-ECIENYYRA-KGKCTPCMNCTA---------------------------------------------ECRHH M_domestica_ENSMODP00000022511 ENQYQQ---SQGKEENGLFKCVPCNP-CFNGTI--QRPCQEKQDAVC-LCNPDFFWN-GDKCISCNECLPGE-------------------------------------------KCSPF G_aculeatus_ENSGACP00000011439 DGYFFL---G------RHALCLPCSK-CTPGEG-VTRECGPHGDTRCEVCGPGTFSEERFSTKPCQACTQCSDSEVEIRHCMPNADALCMDRKLHILSPTLGGSDAPRLPGVGEGETSSV C_familiaris_ENSCAFP00000022390 PGMFCV---HW---DTECVHCEPLSD-CPPGTEAELTDEVGVANSNCVPCKAGHFQNTSSPRARCQPHTRCEEQGLVEAV-----------------------------------PGTAK P_troglodytes_ENSPTRP00000007808 KNQYRH---YW---SENLFQCFNCSL-CLNGTV--HLSCQEKQNTVC-TCHAGFFLR-ENDCVSCSNCKKSL-------------------------------------------ECTKL M_domestica_ENSMODP00000031142 PGWFRECSVSLCRADSP-FVCIRCLD-CEALHR-QTQSPCSRKDTDCGRCLPGFCQD-QNGCAPC--------------------------------------------------ATSGT M_domestica_ENSMODP00000022515 QGMYCP---NG---GTDCEHCEPLSS-CPPGTEPELTDKIGEFDNNCVPCSDGYFQNISSPDVRCQPHTNCEAQGLVTSV-----------------------------------PGTAV M_mulatta_ENSMMUP00000021657 EGRYLE-----------IEFCLKHRS-CPPGFG-VVQAGTPERNTVCKRCPDGFFSNETSSKAPCRKHTNCSVFGLLLTQ-----------------------------------KGNAT E_caballus_ENSECAP00000014162 KNQYRK---YWSETSETRFQCLDCSL-CINGTV--HLPCQERQNTVC--THTGFFL--ENECMSCVKCKKDA-------------------------------------------ECTKL 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000276431 VTSS-PGTPASPCSLSGIIIGVT---VAAVVLIVAVFV-CKSLLWKKVLPYLKGICSGGG---------GDPER----VDRSS---------QRPGAEDNVLNEIV-SILQ--PT-QVPE P_troglodytes_ENSPTRP00000034375 VTTS-PGTPASPCSLSGIIIGVA---VAAVVLIVAVFV-CKSLLWKKVLPYLKGICSGGG---------GDPER----VDRSS---------QRPGAEDNALNEIV-SILQ--PT-QVPE P_pygmaeus_ENSPPYP00000020655 ---------------SGIIIGVT---VLVVVLIVAVFA-CTSSLWKKVLPYLKGICSGGG---------GDPER----LDRSS------HSPQRPGAEDNALNEIV-SILQ--PT-QVPE G_gorilla_ENSGGOP00000010773 VTTS-PGTPASPCSLSGIIIGVA---VAAVVLIVAVFV-CKSLLWKKVLPYLKGICSGGG---------GDPER----VDRSS---------QRPGAEDNALNEIV-SILQ--PT-QVPE P_pygmaeus_ENSPPYP00000020658 --------------------------VWVIL---AVIL-IVLLLLVAVVIACCCISSGCG---------VDPKC----MDRMC-FW-CLRLLREPGAEDNAHNEIL-SNADSLST-FVSE P_troglodytes_ENSPTRP00000034378 --------------------------VWVIL---VVTLVVVPLLLVAVLIVCCCIGSGCG---------GDPKC----MDRVC-FW-RLGLLRGPGAEDNAHNEIL-SNADSLST-FVSE H_sapiens_ENSP00000221132 --------------------------IWVIL---VVTL-VVPLLLVAVLIVCCCIGSGCG---------GDPKC----MDRVC-FW-RLGLLRGPGAEDNAHNEIL-SNADSLST-FVSE G_gorilla_ENSGGOP00000002136 --------------------------VWVIL---VVTL-VVPLLLVAVLIVCCCIGSGCG---------GDPKC----MDRVC-FW-RLGLLRGPGAEDNAHNEIL-SNADSLST-FVSE E_caballus_ENSECAP00000022015 VTVGLPTTPSRSSGNPWPVIGIV---AVAVAVAVLLLG-LTVYLYRRRI--LQGECPLLG---------ADAPR-------------PVGSAERPEALDNAYNETL-NNRESSST-LVSE M_mulatta_ENSMMUP00000021894 --------------------------VWAILIVIVVIL-VVLLLLVAVLMFCRRIGSGCG---------GNPKC----MHRVF-LW-CLGLLRGPGAEDNAHNMIL-NHGDSLST-FISE M_mulatta_ENSMMUP00000009898 VTTS-PGTPASPCSFSGIIIGVI---VLVVIVVVAVIV-WKTSLWKKVLPYLKGVCSGGG---------GDPER----VDSVS------WFLQELGAQAQELLPGT-------------- M_mulatta_ENSMMUP00000021892 VPTS-LGTPDL--YGLIAGV------VTVFIILFAAAF-VCILRRKKLISSLKGICSGGG---------GDPER----VHRVF-FR-RSRPSRVPGMEDNARNESL-STRFLQPT-QVSE P_pygmaeus_ENSPPYP00000020657 VTTS-LGTLASPCCLAAIII------GILVSIPVAAGL-VYILRRKKLISYLKGICSGGG---------GGPER----VHRFL-FRRHSCPSQVPGAEDNARNETL-SSSYLQPT-QVSE H_sapiens_ENSP00000310263 VTTI-LGMLAS--PYHYLII------IVVLVIILAVVV-VGFSCRKKFISYLKGICSGGG---------GGPER----VHRVL-FRRRSCPSRVPGAEDNARNETL-SNRYLQPT-QVSE G_gorilla_ENSGGOP00000007840 VTTI-LGMLAS--TYHYLII------IVVLVIIFAVVV-VGFSCRKTFISYLKGICSGGG---------GGPER----VHRVL-FRRRSCPSRVPGAEDNARNETL-SNRHLQPT-QVSE P_troglodytes_ENSPTRP00000034377 VTTI-LGMLAS--TYHYLII------IVVLVIILAVVV-VCILCRKKFISYLKGICS------------------------VL-FRRCSSPSRVPGAEDNARNETL-SNRYLQPT-QVSE M_musculus_ENSMUSP00000022663 ----------ASWHKLGLWIGLL---VPVVLLIGALLV-WKTGAWRQWLLCIKRGCE-----------------------------------RDPESANSVHSSLL-DRQTSSTT-NDSN P_troglodytes_ENSPTRP00000034372 VTTI-LGMLAS--PYLYLII----------IVVLAVVV-ICILCRKKFMSYLKGICSGGG---------GGPKR----VHR--------------------------------------- G_gorilla_ENSGGOP00000010787 VTTI-LGMLAS--XSRLLII------IXGSVIIFAVVV-VGFLCLKKFISYLKGICSGGG---------GGPER----VHRVL-FRQRSCPSRVPGAEDNACNETL-SNRYLQPT-QVSE H_sapiens_ENSP00000349324 MNTS-PGTPAPAAEET--------------------------------------------------------------------------MNTSPGTPAPAAEETM-TTSPGTPA-PAAE P_troglodytes_ENSPTRP00000034376 MNTS-PGTPAPAAEET--------------------------------------------------------------------------MNTSPGTPAPAAEETM-NTSPGTPA-PAAE G_gallus_ENSGALP00000000612 --------------SSXLLQ------VITFTVLLAVILGLVLVFWKRCSSRHHGAGDDGELSWKP-------------------SAVVNRLLQRLGIQDNRCNEQIYQNQQQQEL-LFTA R_norvegicus_ENSRNOP00000055444 ----------IPQHNLGLIIGLL---ASVISVVLFVAVIWKTKAWESVCLFMTRVYPGCE----------------------------------QDHENTVGLSLL-DAQTSRKT-NGSH M_domestica_ENSMODP00000011508 MGGQSPHTHQWVCQRVSIEVSLD---VAVPMLFSHWII-VKFNLYWVLSVFLPFSASSRAGQTGYLMGDREKEK----------------PYLWGSSREPLLSYLV--SLLQRGN-HPRP P_pygmaeus_ENSPPYP00000020656 MNIS-LGTP--------------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000010781 MNTS-PGTPAPAAEET--------------------------------------------------------------------------INTSPGTPAPAAEETM-TTSPGTPA-PAAE O_latipes_ENSORLP00000003602 ASAS---------QTHLVLYVFL---LLLVAIIVGVAIWWFKGRPSCQ----TPCKLKPFSVVRRE--ESLSEQ----RNRQD-SHRKS----NFCTAVRSFPALC-------------- O_anatinus_ENSOANP00000021880 -------------------LWIL---SALPLFLLLVAG-LALGRYYLCNSSAGGSISANSVVLSRL-------------------------IGTYGWPEFPLCYFF-------------- T_nigroviridis_ENSTNIP00000001044 NPSS---------TLKTVIFAVLG--VVLFLLLLGLAAWRFRQRFVAI----KTDQASLFVSGKPD--KSGATA----EEQQN-DQNADL--EEFRP--ESRPLLQ-ETQPGMTK-HSPP T_rubripes_ENSTRUP00000013812 SPAT---------VVSVIV-------VLLVLVLIGLAVWWFKQHPGETG---IRSHSSDIKIRIQD--GNDPSA----EERQN-SQNAGLEGEEPRP--ESRPLLQ-ETQHGVTK-PSPP G_gallus_ENSGALP00000038567 --------------FAWMIIGIF--------AAVGFAGLLAFCAIRKCKSAKATLSDKAE---------RGPED----EDNML-LQEVKVIRNNASHPDNEN-----SGESPEGQ-AYND T_rubripes_ENSTRUP00000010129 APPT---------VGVSVIVPLSLAAVAVIIFVVIFVCIWKRRKRA------VQVHCQQLRNECLS--VVGTEK----PVRIN-KPFQALHDEGGGRG-PHRPSIINARQLVRTN-SFKH G_aculeatus_ENSGACP00000007142 SPAS---------GNALWWLP-----VLVIGVFVAIGVLGCFVLKRRTAT--GEYSDLQEQSDSDE--DSGNER---------------------SSGEAQRLSCLGGMMPWRLV-RASG D_rerio_ENSDARP00000012354 SSTS---------MTFIVIMP-----LIVLLACVLCIVYWTKSKQNKTAAPVTSRSPREMVKICMG--DSEEVR----EEKQN-DHNSRIDDSS-----QLQPFLEQNYVVGTSV-PHPS D_rerio_ENSDARP00000010724 SNST---------GTIVVIVSILI--LLVICAIVGAILFLKRRQRQQS----ETDGNLEEVKVPID--ECPRSE----EEQEN-SRNAGLEKEEEHRP-ESRPLLTQETQETGSK--SIP G_gallus_ENSGALP00000023975 CSSPVTTSPNSSELNGNLVLGIIVAIFVVICVIYVVNKAVKLVQKNGIASSFYSCVSLPQTSKESV--------------------------SEAEVKGSAI-TVLPEIQKEKEL-LVNA O_latipes_ENSORLP00000020293 -----------SLDAVFFVLCV----IPVVLFLVAGGIFLKYKK--KCGCRGFQVHTHSHFEACSS--ESSTKA----KPRKI-SSNKGRMNF------SDFPSMEVED----------- G_aculeatus_ENSGACP00000020911 CSTS---------QVAPVWISLI---VIAIAIAAALAVWWLLVKRRSCSR--SHCDSSEIVKIPID--ESGSTA----EERQN-HQNAGLEGEECRP--ESRPLLQ---ETGMTK-ASPP B_taurus_ENSBTAP00000005522 CPTRPSTGKDSQDPGTTVLLPLV---IVFGLCLASFASVVLACRYQRWKPKLYSIICGQSTLVKEG-----EPE----LLVPAPGFNPTTTICFSSTPSSSPVS---------IP-PYIS T_rubripes_ENSTRUP00000011080 CSVTLSCSKGDESTKGFLYNSIGV-ATAGLTLLLLVAAVTHVVTKSVTLRRLQEFPSQSS----------------------------------AVTPDPCKEILIPSEESSFDI-TFKV T_guttata_ENSTGUP00000013762 CPSPVTTSPTSSGLNGNLVLGTLVAIFGVIFVLCVARKVGKLVQKDKIVSSFYSCVSLPQTPKEPV--------------------------SEVEKKRNKISTLIPESQKETEL-PLNA O_anatinus_ENSOANP00000007822 HDTLCTRCDNFQLNSS-----------------------------------------------------------------------------EPGNKDCEQAL---------------- G_aculeatus_ENSGACP00000013477 CSTSLPVTTKASTNDQYLNKIIAVFAFIAPVSVMVVVLVTYVATKRFTKKKLLKRSNLPS----------------------------------DGSPDPCEQVLVHSEEPSDNM-GVTA M_domestica_ENSMODP00000022511 CPSK------SMDPGETVLMVLV---IFLGFCCLSLIVTVFFCQYSRWKSKLYLIVCPRKAPEKEVTKTRCGAHFIIIHPPPKHGQSLAPSLKSDSTPISTQVPSYSPGTPCPGP-SFQV G_aculeatus_ENSGACP00000011439 PGTPRFTPPDDGGSNHILAYVSVLAAVVLGLIFYVAYKCWRSCQQKRALSKARAAELGASPEGEKL------------------QSDSGVFLDSQSLQENQPSKGTKRDSKQDNR-LYIN C_familiaris_ENSCAFP00000022390 SDTSCRNPLEHSETPGTVMVLAIL----LPLASFLFLTTVLACTWKNHPSLCRKLGSLLK---------RRPEG----EESNTADGSWEPPRVNPHFPDLVKPLLPFSGDLASAS-ARLP P_troglodytes_ENSPTRP00000007808 CLPQIENVKGTEDSGTTVLLPLV---IFFGLCLLSLLFIGLMYRYQRWKSKLYSIVCGKSTPEKEGELEGTTTK----PLAPTPSFSPT-------------------------P-GFTP M_domestica_ENSMODP00000031142 KVIEILILDPPSLSGSWLQYFLL---ASMVLMILLLLGWGLFYSYQKCFVPMPRAHWNGSSLCFQV---ISPSPVGRASLPLNSYSEKICALQLVGNCSPSSPTLVREVQSPEDAWPMLW M_domestica_ENSMODP00000022515 SDARCQN--SPPKMPGKISIVILLKIRARKILKFRKIFTVFSCAWKRHPSLCRKLGLLLK---------RRPER----EDPNPPPNQ-DIPRTNQKYPDLVELLLDSSGTAPVAL-NGHP M_mulatta_ENSMMUP00000021657 HDNICSGNSEST-QKCGIDVTLCEEAFFRFAVPTKFTPNWLSVLVDNLPGTKVNAESVER------------------------------IKRRHSSQEQTFQLLKLWKHQNKDQ-DIVK E_caballus_ENSECAP00000014162 CPSPTQSVTGRQDPGATVLLPLV---IFLGLCLLSLLSIGFLCRYRRWKPKLRSIVCGKSTPVKEA--QAGEPE----PLAPTPSFSPTAAL--SVIPGYSPVS---SSTFTPIP-NFTP 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000276431 QEMEVQEPAEPTGVNM------------------------------LSPGESEHLL-EPAEAERSQ-R---------RRLLVPANEG--------D--PTETLRQ--CFDDFADLVPFDS P_troglodytes_ENSPTRP00000034375 QEMEVQEPAEPTGVNM-------------------------------SPGESEHLP-EPAEAEGSQ-R---------RRLLVPANEG--------D--PTETLRQ--CFDDFADLVPFDS P_pygmaeus_ENSPPYP00000020655 QEMEVQEPAEPTGVNM------------------------------LSPGESEHLP-EPEEAEGSQ-R---------RRLLVPANEG--------D--PTETLRQ--CFDDFADMVPFDS G_gorilla_ENSGGOP00000010773 QEMEVQEPAEPTGVNM------------------------------LSPGESEHLP-EPAXXXXXX-X---------XXXXXXXXXX--------X--XXXXXXX--XXXXXXXXXXXXX P_pygmaeus_ENSPPYP00000020658 QQMESQELADLTGVTV------------------------------QSPGEAQCLL-GPAEAEGSQ-R---------RRLLVPANGA--------D--PTETLML--FFDKFANIVPFDS P_troglodytes_ENSPTRP00000034378 QQMESQEPADLTGVTV------------------------------QSPGEAQCLL-GPAEAEGSQ-R---------RRLLVPANGA--------D--PTETLML--FFDKFANIVPFDS H_sapiens_ENSP00000221132 QQMESQEPADLTGVTV------------------------------QSPGEAQCLL-GPAEAEGSQ-R---------RRLLVPANGA--------D--PTETLML--FFDKFANIVPFDS G_gorilla_ENSGGOP00000002136 QQMESQEPADLTGVTV------------------------------QSPGEAQCLL-XPAEAEGSQ-R---------RXLLVPANGA--------D--PTETLML--FFDKFANIVPFDS E_caballus_ENSECAP00000022015 QELEGKEQAEPTGVSA------------------------------QSPGEAEHLL-GPAGAEGSQMR---------RRLLVPANGA--------D--PTESLQL--FFDYFPRIVPFKS M_mulatta_ENSMMUP00000021894 QQMESQEPADLTGVTV------------------------------QSPGEAQCLL-GPAEPEGSQ-R---------RRLLVPANGA--------D--PTETMML--FFDNFADIVPFNS M_mulatta_ENSMMUP00000009898 --------AEPGWVGP------------------------------HCPHGCPDSLKWPGGS---------------------------------------------------------- M_mulatta_ENSMMUP00000021892 QEIKGQESAEPTGVTV------------------------------QSPEEAQRLL-EQAEAEGRQ-R---------KTLPVPVNDA--------D--PTE------------------- P_pygmaeus_ENSPPYP00000020657 QEIRGQELAEPTAVTV------------------------------ESPEEPQRLP-EQAEAEGCQ-R---------RRLLVPVNDA--------D--SAD------------------- H_sapiens_ENSP00000310263 QEIQGQELAELTGVTV------------------------------ELPEEPQRLL-EQAEAEGCQ-R---------RRLLVPVNDA--------D--SAD------------------- G_gorilla_ENSGGOP00000007840 QEIQGQELAEPTGVTV------------------------------ESPEEPQRLL-EQAEAEGCQ-R---------RRLLVPVNDT--------D--PTE------------------- P_troglodytes_ENSPTRP00000034377 QEIQGQELAEPTGVTV------------------------------ESPEEPQRLL-EQAEAEGCQ-R---------RRLLVPVNDA--------D--SAD------------------- M_musculus_ENSMUSP00000022663 HNTE------------------------------------------------------PGKTQKTG-----------KKLLVPVNGN--------D--SADDLKF--IFEYCSDIVPFDS P_troglodytes_ENSPTRP00000034372 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000010787 QEIQGQELAEPTGVTV------------------------------ESPEEPQRLL---------------------------------------------------------------- H_sapiens_ENSP00000349324 ETMTTSPGTPAPAAEE-------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000034376 ETMNTSPGTPAPAAEE-------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000000612 QGSEVPHGVEMEGTER----------------------------------------RTPDPKVET------------QRKLVPVLGE--------N--PIALLHR--SFNTFVDYVPFPE R_norvegicus_ENSRNOP00000055444 HNTE------------------------------------------------------PDRTQSSPLG---------RKLLVLANGN--------N--PADALKL--IFERCSTEVPFNS M_domestica_ENSMODP00000011508 PEARGDEPLEMQNLSG------------------------------KQREEHEELLEEPAEAMTP------------QAKLFPANGD-----------PIGTLQK--SFVIFAQKVPWQY P_pygmaeus_ENSPPYP00000020656 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000010781 ETMT-------------------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000003602 VTIQYKTMLNSNNEGT---SQPRHTLTLKK-IPRHT--------------SIQKFFLFGAVKSAA------------DFLLGPLTR------------SEKSLRK--SFDLFDEYLDVRI O_anatinus_ENSOANP00000021880 --------------------------------------------------------------------------------MVSVNGV--------HELSEPALEK--ALPHFEREVPCKS T_nigroviridis_ENSTNIP00000001044 LEDEDRGLGDSLPNTT---NSSQTSLSGLP-MTCATTPRPS---------PSAVRIAPADVVSK-------------STHLFMNTC------------PEKSLKM--SFDLFDEYLDVQI T_rubripes_ENSTRUP00000013812 LEDEDRGLGDSLPNTT---NSSQTSLSALPTLTSAITPRQS---------PSAGRMTPVDVEDPL------------RYRLVPVKD------------AEKSLKM--SFDLFEEHLDVRI G_gallus_ENSGALP00000038567 VNSEVKN-TSPEENSAVSYERGTIPQKNLW-CQTRECWKRIKNYSSSPKNRCNSTLQPNTQCKVSGVRMPAYCMVQKQKYQISIKDL-----------TQKEARD--CFFAFIKEVPVKK T_rubripes_ENSTRUP00000010129 TTEERKVLCESLNSSA---SNSQYSLT--G-LTSCSSPASPPVANPAA--PPQPLWRLPSLLTSS------------RRRVSLLAG-------------EESLCN--CFEYFEE-LNMDY G_aculeatus_ENSGACP00000007142 AEEERKALRDSPGSSA---SNSQHNLTAFP-YPYPGFPAPPAQAGPTAPVQP-------------------------DRRLVAVNG-------------EESLRK--CFEYFED-VDVRL D_rerio_ENSDARP00000012354 EAEKDKGLGDSLPNTA---NSSQTSLAICA-VPSDLQSCHTNQSS-----SSVLAWQPPALESES------------SRRLVPLSG-------------EESLKK--TFDFFEE-IDVHY D_rerio_ENSDARP00000010724 VEDEDRGLGDSLPHNQLFPNQSICTPSNHWGFTDPA-------PRPRDRPTEIRLNHGHGLEDDP------------PRKLLPLLG------------EEESLSK--SFDLFDS-LDVRY G_gallus_ENSGALP00000023975 T--------------------------------------------------------PPSVPLLQSSHELPDCVRAARKRQLPDNPA--------------------ILYTVVDHVPPSR O_latipes_ENSORLP00000020293 PHHKKKQLFSLPPVVM------IHSGTGLS-YPSPL--------------SLRVRFTWSLLSKQEEEQ---------LPTLIPVNG-------------EQSLRS--CFELFEE-LDVDF G_aculeatus_ENSGACP00000020911 LEDEDRGLGDSLPNTT---SSSQTSLSALV-QTVCVSPSMP-------------------YDDPL------------QHRLVPVQGEISCSGGDLPKGSEKSLKK--SFDLFDEYLDVRI B_taurus_ENSBTAP00000005522 CDRSNFGAVASPSSET----APPHLKAGPI-LPGPPASTHLCTPGPPASTHLCTPGPPASTHLCTPVQKWEASAPSAPDQLADAD-------------PA-------TLYAVVDGVPPSR T_rubripes_ENSTRUP00000011080 ATITPLSECEQPVK---------------------------------------------------------------LPDCIPVEIKLSE-----------------LIYTVLDLVPVLQ T_guttata_ENSTGUP00000013762 A--------------------------------------------------------LSSIPPPQSSHELPDCVRPARKTQLPDNPA--------------------VLYAVVDHVPPSR O_anatinus_ENSOANP00000007822 -----------------------------------------------------------------------------------------------------------IDFVAYQDIPLKR G_aculeatus_ENSGACP00000013477 VPQSPVGEQEPSN----------------------------------------------------------------LPDCIPLEIKTPD-----------------LIYTVLDLVPVLQ M_domestica_ENSMODP00000022511 HSSTPLR-APAPSLNSSFYSLPPNNWQPPI-----------------------NIQRTEWAPLPDPIN----CSAQMPSHSATSDDT--------ALHPA-------MLYTVVDQVPPQR G_aculeatus_ENSGACP00000011439 LPPHRQE----------------------------------------------------------------------------------------------------EVERLLQEGGGRG C_familiaris_ENSCAFP00000022390 APPSLEE------------------------------------------------------------------------------------------------------EMLQQQSPLSQ P_troglodytes_ENSPTRP00000007808 ----------TPRREV----PPPYQGADXI-----------------------LATALASDPIPNPLQKWEDSAHK-PQSLDTDD-------------PA-------TLYAVVENVPPLR M_domestica_ENSMODP00000031142 SQPPSRGSGEQDGLNA----------------------------------------------------------------RAPSSLRRRDGEQGSDGPGAGTLQPGPQLYEVMDAVPARR M_domestica_ENSMODP00000022515 PSPAMET------------------------------------------------------------------------------------------------------EPLRQQSPPDQ M_mulatta_ENSMMUP00000021657 KIIQDIDLCENSV----------------------------------------------------------------------------------------------QRHIGHANLTFEQ E_caballus_ENSECAP00000014162 SDWRNFS-AASPPREM----APPYQEAGPI-----------------------LTAVPPSSPLSTPVQKWEDSAHT--QRPDSDR-------------PG-------TLYAVVDGVPPSR 610 620 630 640 650 660 670 680 690 700 710 720 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000276431 WEPLMRKLGLMDNEI-K-----VAKAEA-AGHRDTLYTMLIKWVNKT-GRDAS----------VHTLLDALETLGERLAKQKIEDHLLSSGKFM-YLE----------GNA-----DSAM P_troglodytes_ENSPTRP00000034375 WEPLMRKLGLMDNEI-K-----VAKAEA-AGHRDTLYTMLIKWVNKT-GRDAS----------VHTLLDALETLGERLAKQKIEDHLLSSGKFM-YLE----------GNA-----DSAM P_pygmaeus_ENSPPYP00000020655 WEPLMRKLGLMDNEI-K-----VAKAEA-AGHRDTLYTMLIKWVNKT-GRDAS----------VHTLLDALEAMGERLAKQKIEDHLLSSGKFM-YLE----------GNA-----DSAM G_gorilla_ENSGGOP00000010773 XXXXXXXXXXXXXXX-X-----XXXXXX-XXXXXXXYTMLIKWVNKX-GRDAS----------VHTLLDALETLGERLAKQKIEDHLLSSGKFM-YLE----------GNA-----DSAM P_pygmaeus_ENSPPYP00000020658 WDQLMRQLDLTKNEI-D-----VVRAGI-AGPGDALYAMLMKWVNKT-GRNAS----------IHTLLDALERMEERHAKEKIEDLLVDSGKFI-YLE----------DGT-----GSAV P_troglodytes_ENSPTRP00000034378 WDQLMRQLDLTKNEI-D-----VVRAGT-AGPGDALYAMLMKWVNKT-GRNAS----------IHTLLDALERMEERHAKEKIQDLLVDSGKFI-YLE----------DGT-----GSAV H_sapiens_ENSP00000221132 WDQLMRQLDLTKNEI-D-----VVRAGT-AGPGDALYAMLMKWVNKT-GRNAS----------IHTLLDALERMEERHAREKIQDLLVDSGKFI-YLE----------DGT-----GSAV G_gorilla_ENSGGOP00000002136 WDQLMRQLDLTKNEI-D-----VVRAGT-AGPGDALYAMLMKWVNKT-GRNAS----------IHTLLDALERMEERHAKEKIQDLLVDSGKFI-YLE----------DGT-----GSAV E_caballus_ENSECAP00000022015 WKRLMRQLGLTQNEI-D-----VMEAEI-TSHQDALYEMLTIWLKKT-GRSAS----------VNTLLDALETLGEKYAKETIQDHLLASGKYV-YEE----------GGA-----GSAV M_mulatta_ENSMMUP00000021894 WDQLMRQLGLTNNEI-H-----MVRADT-AGPGDALYAMLMKWVNKT-GQDAS----------IHTLLDALERIGERHAKERIQDLLVDSGKFI-YVE----------DGT-----GSAV M_mulatta_ENSMMUP00000009898 --------GLTVGDT--------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000021892 ---------------------------------------------------------------INTLLDASATLEEGHAKETIQDHMVDSEKLF-Y-E----------DDA-----GFAT P_pygmaeus_ENSPPYP00000020657 ---------------------------------------------------------------ISTFLDASATPEEGHAKETIQDQLVGSEKLF-YEE----------DDA-----GSAT H_sapiens_ENSP00000310263 ---------------------------------------------------------------ISTLLDASATLEEGHAKETIQDQLVGSEKLF-YEE----------DEA-----GSAT G_gorilla_ENSGGOP00000007840 ---------------------------------------------------------------ISTLLDASATLEEGHAKETIQDQLVGS------------------------------ P_troglodytes_ENSPTRP00000034377 ---------------------------------------------------------------ISTLLDASATMEEGHAKETIQDQLVGSEKLF-YEE----------DEA-----GSAT M_musculus_ENSMUSP00000022663 WNRLMRQLGLTDNQI-Q-----MVKAET-LVTREALYQMLLKWRHQT-GRSAS----------INHLLDALEAVEERDAMEKIEDYAVKSGRFT-YQN----------AAAQPETGPGGS P_troglodytes_ENSPTRP00000034372 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000010787 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000349324 ------------------------------------------TMITSPGTPASSHYLSCTIVGIIVLIVLLIVFV--------------------------------------------- P_troglodytes_ENSPTRP00000034376 ------------------------------------------KMTTSPGTPASSHYLSCTIVGIIVLIVLLIVFV--------------------------------------------- G_gallus_ENSGALP00000000612 WKRFGRALDLQENDL-Y-----LAEQHD-RVSCEPFYQMLNTWLNQQ-GSKAS----------VNTLLETLPRIGLSGVADIIASELISKGYFQ-YEV----------S----------- R_norvegicus_ENSRNOP00000055444 WDRLMRHMGLTDNQI-Q-----MVRAET-QVPCEVLYQMLLKWLYQT-GLGAS----------INHLLGALEAVGERCALEEIEDYAVKSGKFV-YQN----------TTA--------- M_domestica_ENSMODP00000011508 WNQYMNLLGLSPNEI-------AMAKES-ENVIDYPHRMLTMWQQKV-GKAAT----------VDILLETLSKIKLKAARESIQEELIHEKLYV-YKE----------SEPEKSLT---- P_pygmaeus_ENSPPYP00000020656 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000010781 ---------------------------------------------TSPGTPASSHYLSCTIVGIIVLIVLLIVFV--------------------------------------------- O_latipes_ENSORLP00000003602 HNKFFRLIGISDNHI-R-----I--AEN-GAAADKVYELLKNWMQKQ-GLKAD----------INNLLDALLSLDQRRSAECIAYEALRKGYYR-HAD----------V----------- O_anatinus_ENSOANP00000021880 WNGYMIRLGLSQNEI-D-----VARGSE-RYTEDQPRSLLRTWQIKM-GKGAS----------INTMLETLDEMRLKLIRESIQESLIDSKLYV-FAS---------------------- T_nigroviridis_ENSTNIP00000001044 HNKFFRMIGISDNHI-H-----L--AES-CSPPDKVYKLLTTWMQKQ-GRRAD----------INSLLNALLSMDQRRSAESVASAALLKGYYK-HAE----------T----------- T_rubripes_ENSTRUP00000013812 HNKFFRAIGVSDNDI-R-----I--AQT-----DKVYELLKNWMQKQ-GLKAD----------INDLLGVLLRMDQRRSAESIASDALRKGYYK-HAE----------TP---------- G_gallus_ENSGALP00000038567 WRKLMRT-HLEENDI-D-----KIIYNWPNDIDEQSYQMLLMWKNKM-GEKQS----------IIKLLDELWDIDTRAYSNIVHTLTSNNIISK-KEA----------TA---------- T_rubripes_ENSTRUP00000010129 HKKFFRHLGISDNTI-K-----A--KEG-LPYEDRIHALLNVWIEKA-GSEAS----------LNDLLQVLLNLGQCRTAEVIKEKAVHHRHYR-CE----------------------- G_aculeatus_ENSGACP00000007142 HSRFFRHLDVADNVI-K-----S--KDH-LAYYDRIHELLTIWVEKA-GRGAT----------LNDLLRALLNLKQRRTAEIIKEKAIRNGHYV-EAQ----------G----------- D_rerio_ENSDARP00000012354 HNRFFRLIGLSDNAI-K-----S--AES-LFPEDRVYELLKIWMEKE-GLKAD----------FNSLIDALIYLDQRLSAENIIAKAINNSCFK-YEE----------E----------- D_rerio_ENSDARP00000010724 HNKFFRSIGVSDNSI-K-----L--AET-QQPMDKVYDLLRVWMQKE-GLRAN----------INTLLQALLDLDQRYSAEHIASKAVERGYYK-YE----------------------- G_gallus_ENSGALP00000023975 WKEFVRRLGLTENDL-E-----RIEMEH-RHLRDAQYEMVSLWKLQM-GHAAT----------VEHISCVLNQMELSGCSEAIQEALLNQNSHQ-PCS----------FHSHR------- O_latipes_ENSORLP00000020293 HKKFFRRLDFSDNAI-K-----S--KDN-LLYEDKIHELLNSWVERE-GKKAN----------LNELLKVLVELNQKRTAEKIMKKVLDNGQYC-TES----------K----------- G_aculeatus_ENSGACP00000020911 HNKFFRLIGVSDNHI-R-----I--AES-GPPGDKVYELLKNWMQRR-GLKAD----------INDLLEALLTMDQRRSAESIASEALRRGYYK-HA----------------------- B_taurus_ENSBTAP00000005522 WKELVRRLGLSEHEI-E-----RLELENGRHLREAQYSMLAAWRRRTPRREAT----------LELLGRVLRDMDLLGCLENIEEALGGAARLA-SEP----------RLLR-------- T_rubripes_ENSTRUP00000011080 VKQLVRSLGVRDTEI-E-----QAELDY-RPCREAHYQMLRAWAERG-SGAGT----LLHPPLLHDLLNELRKMHLGQAAEELEKKSLDTSSTLS------------------------- T_guttata_ENSTGUP00000013762 WKEFVRRLGLSDYDL-E-----RIELEH-RRLRDAQYEMLRLWKLQT-GHAAT----------LEHIGRVLNQMELSGCSDAVQESLLNQNSPQ-PCS----------LHNHL------- O_anatinus_ENSOANP00000007822 LLRLQQVLGKRGGRR-------SDQGFQVVMQKKLLQQLMEKKEAQT--SDAL----------ITELLQALRTVKLYGLIEKIQKHFSLH------------------------------ G_aculeatus_ENSGACP00000013477 VKQLVRSLGVKDAEI-E-----QAEMDH-RSCREAHYQMLRVWAERGSHAGAGGRGGMMHWHLLQELLDEVRKMHLGHAAEELETKELDDNDLVS------------------------- M_domestica_ENSMODP00000022511 WKEFVRRLGLSPNAI-E-----FLEMQNSRCLREAHYSMLEAWQKGVPRHQAT----------LETLALVLQEMKLCGCLQNIREALEQDSPCR-PRT----------PFPR-------- G_aculeatus_ENSGACP00000011439 WRQLGAALGYEPEQL-D-----LFGRGE-----APAHTLLSNWAPKE---GST----------LGLLWSALARIERPDVVTAINCPTQGVSLV--------------------------- C_familiaris_ENSCAFP00000022390 ARELEPELPEQGQVA-HGTNGIHVTGGS-VTVTGNIYIYNGPVLGGARGPGDPPASPEPPYPTPEEGAPGPPGLSTPYQEDGKAWHLAETETLG-CHA----------L----------- P_troglodytes_ENSPTRP00000007808 WKEFVRRLGLSDHEI-D-----RLELQNGRCLREAQYSMLATWRRRTPRREAT----------LELLGRVLRDMDLLGCLEDIEEALCGPAALP-PAP----------SLLR-------- M_domestica_ENSMODP00000031142 WKEFVRTLGLREAEI-E-----AVEAEI-GRFRDQQYEMLKRWRQQQ---PAG----------LDAVYAALERMGLEGCAEDLRSRLQRGP----------------------------- M_domestica_ENSMODP00000022515 GRDQGTEPGEQGQEVHHGTNGFLVSGGS-VTVKGNIYIYNGPVLGGARGPGDPPLSPDPPYPVPEEGTPNLLRFSEPHQEDGKAWHLAETETLG-CYA----------H----------- M_mulatta_ENSMMUP00000021657 LRSLMESLPGKKVGAED-----IEKTTKACKPSDQILKLLSLWRIKN-GDQDT----------LKGLMHALKHSKTYHFPKTVTQSLKKTIRFLHSFTMYKLYQKLFLEMIGNQVQSVKI E_caballus_ENSECAP00000014162 WKEFMRRLGLSEHEI-E-----RLELQNGRCLREAHYSMLAAWRRRTPRREAT----------LELLGSVLRDMDLLGCLEDIQEKLCAPASHS-PAP----------RLPR-------- 730 === H_sapiens_ENSP00000276431 S-- P_troglodytes_ENSPTRP00000034375 S-- P_pygmaeus_ENSPPYP00000020655 S-- G_gorilla_ENSGGOP00000010773 S-- P_pygmaeus_ENSPPYP00000020658 SLE P_troglodytes_ENSPTRP00000034378 SLE H_sapiens_ENSP00000221132 SLE G_gorilla_ENSGGOP00000002136 SLE E_caballus_ENSECAP00000022015 S-- M_mulatta_ENSMMUP00000021894 SLE M_mulatta_ENSMMUP00000009898 --- M_mulatta_ENSMMUP00000021892 SSL P_pygmaeus_ENSPPYP00000020657 SCL H_sapiens_ENSP00000310263 SCL G_gorilla_ENSGGOP00000007840 --- P_troglodytes_ENSPTRP00000034377 SCL M_musculus_ENSMUSP00000022663 QCV P_troglodytes_ENSPTRP00000034372 --- G_gorilla_ENSGGOP00000010787 --- H_sapiens_ENSP00000349324 --- P_troglodytes_ENSPTRP00000034376 --- G_gallus_ENSGALP00000000612 --- R_norvegicus_ENSRNOP00000055444 --- M_domestica_ENSMODP00000011508 --- P_pygmaeus_ENSPPYP00000020656 --- G_gorilla_ENSGGOP00000010781 --- O_latipes_ENSORLP00000003602 --- O_anatinus_ENSOANP00000021880 --- T_nigroviridis_ENSTNIP00000001044 --- T_rubripes_ENSTRUP00000013812 --- G_gallus_ENSGALP00000038567 --- T_rubripes_ENSTRUP00000010129 --- G_aculeatus_ENSGACP00000007142 --- D_rerio_ENSDARP00000012354 --- D_rerio_ENSDARP00000010724 --- G_gallus_ENSGALP00000023975 --- O_latipes_ENSORLP00000020293 --- G_aculeatus_ENSGACP00000020911 --- B_taurus_ENSBTAP00000005522 --- T_rubripes_ENSTRUP00000011080 --- T_guttata_ENSTGUP00000013762 --- O_anatinus_ENSOANP00000007822 --- G_aculeatus_ENSGACP00000013477 --- M_domestica_ENSMODP00000022511 --- G_aculeatus_ENSGACP00000011439 --- C_familiaris_ENSCAFP00000022390 --- P_troglodytes_ENSPTRP00000007808 --- M_domestica_ENSMODP00000031142 --- M_domestica_ENSMODP00000022515 --- M_mulatta_ENSMMUP00000021657 SCL E_caballus_ENSECAP00000014162 ---