10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000287295 MFRCGGLAAGA-----------------------------LKQKLVPLVR---TVCVRSPRQRNRL------------------------------------------------------ M_mulatta_ENSMMUP00000006568 MFRCGGLAAGA-----------------------------LKQKLVPLVR---TVCVRSPRQRNRL------------------------------------------------------ E_caballus_ENSECAP00000002768 MFRCGGLAAGA-----------------------------LKQKLAPLVR---TVCVRGPRQRNRL------------------------------------------------------ C_familiaris_ENSCAFP00000027660 MFRCGSLAAGA-----------------------------FKQKLAPLVR---TVCVRGPRQRNRL------------------------------------------------------ B_taurus_ENSBTAP00000008987 MFRCGGLAAGA-----------------------------LKQKLAPLVR---TVCVRGPRQRNRL------------------------------------------------------ P_pygmaeus_ENSPPYP00000023188 MFRCGGLAAGA-----------------------------LKQKLVPLVR---TVCVRSPRQRNRL------------------------------------------------------ R_norvegicus_ENSRNOP00000008503 MFRCGGL-AGA-----------------------------FKQKLVPLVR---SVCVQRPKQRNRL------------------------------------------------------ M_musculus_ENSMUSP00000041104 MFRCGGL-AGA-----------------------------FKQKLVPLVR---TVYVQRPKQRNRL------------------------------------------------------ M_domestica_ENSMODP00000027578 MLRWGSAAATG-----------------------------LGQKLVPLVQ---TICVRGQKQKSRF------------------------------------------------------ P_troglodytes_ENSPTRP00000038338 MFRCGGLAAGA-----------------------------LKQKLVPLVR---TVCVRSPRQRNRL------------------------------------------------------ O_cuniculus_ENSOCUP00000002538 MFRCGGLAAGA-----------------------------LKQKLVPLVR---TVCVRSPRQRNRL------------------------------------------------------ A_carolinensis_ENSACAP00000008812 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005365 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000006366 M-----------------------------------------------------SCCRLAAAALR------------------------------------------------------- X_tropicalis_ENSXETP00000039440 MALCRVS---------------------------------VLGLRAARGGNQISQRLRLRSTEKRV------------------------------------------------------ D_rerio_ENSDARP00000075330 MFKC-----KT-----------------------------VWNKLAPLARASSTLCLQNARKSVLR------------------------------------------------------ T_rubripes_ENSTRUP00000030183 MLKC-----RS-----------------------------VWRRLAPLARASSTVC----RQNARR------------------------------------------------------ T_nigroviridis_ENSTNIP00000014785 MLQC-----RT-----------------------------VWTRLAPLARASSTVC----RQNVRR------------------------------------------------------ G_aculeatus_ENSGACP00000026857 MLKC-----RT-----------------------------VWRTLAPLARTSSTVC----RQNARR------------------------------------------------------ O_latipes_ENSORLP00000012070 MLKC-----RT-----------------------------VWRKLAPLAKSSSTLC----RQNVRR------------------------------------------------------ G_gorilla_ENSGGOP00000007470 MFRCGGLAAGA-----------------------------LKQKLVPLVR---TVCVRSPRQRNRL------------------------------------------------------ C_intestinalis_ENSCINP00000012225 MFRCVRLCEHSSSISRS-----------------------LLNKNAPKTQAV-------------------------------------------------------------------- A_gambiae_AGAP008044-PA MLSVSRVAVGNVRCVQPALVRIRKHVLAGGFTQTFGSRRWISVKVNQALLAKEAEPNRRRRQTLKEREAESNEPCSCVEEEGPNSSTIVTPCDESRRLPMMGELIQFPNDPS-------- A_aegypti_AAEL002016-PA MLAVSRAAISNLRIAQPRVATIRARKQFAG--GSFCSRRWFTKKVNDLITRQVTE---RRRRLLEASGACQSPPYPGCSSERTKPSQ--YGCIDPDRTPMIGEDIQFPGGVQDQSREEVV T_guttata_ENSTGUP00000016816 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0077504 MSIWGVRCLTQRFIRQAYILANRRLLGPVP--QR------SPPAYAPLRPAHSSLYQMVKKRTLEARTKLQANKYPNHQVCVTKPST--TPPVEEYETAVEGAGVPAYANAQFQAHSQSE C_elegans_Y56A3A.32.1 MLLRAVGRQMTSVIFRQQTAVRSIAMSRVALGGGGHHHEPTPVYIPKPGSLDWTFFSRSHTKSAHEFEPYKPEIGAFIGAVAFIGLTLIAVVIKTDVFKKEDSHGHGHGHAKHSKKHEEK O_anatinus_ENSOANP00000025948 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000013415 M------------------------------------------------------------------GGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRAYQGNGTARHFHTEER P_troglodytes_ENSPTRP00000024275 M------------------------------------------------------------------GGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRAYQGNGTARHFHTEER H_sapiens_ENSP00000382120 M------------------------------------------------------------------GGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRAYQGNGTARHFHTEER T_guttata_ENSTGUP00000010972 M------------------------------------------------------------------GGCFSKPKPVEVKIEVVIPEKERSKEEMSPNGKASPLIYKVNGTARHYHLEEH M_mulatta_ENSMMUP00000026974 M------------------------------------------------------------------GGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRAYQGNGTARHFHTEER A_carolinensis_ENSACAP00000010903 M------------------------------------------------------------------GSCFSKSKPVEVKIEVVLPEKERAKEEMSPNGKASPIIYKANGTSRHYQLEEH T_nigroviridis_ENSTNIP00000021125 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000015763 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000053272 M------------------------------------------------------------------GGCFSKPKPVELKIEVVLPEKDRGKEELSTGSRGSPRAYQGNGAARHFHADER O_latipes_ENSORLP00000009976 M------------------------------------------------------------------GGCFSKPKAVEVKVELSLLEKEKDLDGLSPNGKASPFADCRPNGALGHGSEDD G_gallus_ENSGALP00000012503 M------------------------------------------------------------------GGCFSKPKPVEVKIEVVIPEKERSKEEMSPNGKASPLVYKVNGTARHYHLEEH D_rerio_ENSDARP00000085557 M------------------------------------------------------------------GGCLSKPKPVEVKVELTLLDKEKEVDLMSPNGKASPFSECRPNGSLGHCSDED M_musculus_ENSMUSP00000111349 M------------------------------------------------------------------GGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRGYQGNGTARHFHAEER G_gallus_ENSGALP00000039047 -----------------------------------------------------------------------------------------------------------------------R O_latipes_ENSORLP00000010037 M----------------------------------------------------------------------------------------------------------------------S R_norvegicus_ENSRNOP00000048427 M------------------------------------------------------------------GGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRGYQGNGTARHFHAEER T_rubripes_ENSTRUP00000040612 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000012379 M------------------------------------------------------------------GGCFSKPKPVEVKVELSLLEKEKDVDGLSPNGKASPFADCRPNGALGHGSDDD T_nigroviridis_ENSTNIP00000018986 ----------------------------------------------------------------------------VEVKVELSLLDKEKEMEGLSPNGKASPFADCRPNGALGHGSDDD G_aculeatus_ENSGACP00000011210 M------------------------------------------------------------------------------------------------------------------NRCKG T_guttata_ENSTGUP00000005877 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0080714 M----------------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000040932 M------------------------------------------------------------------GGCFSKPKPVEVKVELSLLDKEKEMDGLSPNGKASPFADCRPNGALGHGSDDD X_tropicalis_ENSXETP00000057179 M------------------------------------------------------------------GGCFSKPKPVEVKVEVVLPEKEREKEEMSPNGKASPLAYKANGTTRLYHHEER A_carolinensis_ENSACAP00000014484 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003241 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000027082 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019217 ------------------------------------------------------------------------------------------------------------------------ C_elegans_F20D6.11 M----------------------------------------------------------------------------------------------------------------ALANWLT T_rubripes_ENSTRUP00000030429 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0070319 MLDWPFCLSVSKVGGLQIRKKWQSPRTALS--LV------KTKRAFEGLLRIRKLPSSQSWRILNAPSFASHINNRLLNTMGSVNCKEYKTTGSTPKKEKSTGGAVGSYQSKCSNQSPST A_aegypti_AAEL011158-PA ML-----------------------------------------------------------------RAALQISNRLVIPARSRGNDSRKMMSLLSK----------------------- 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000287295 ---------------------PGNLFQRWHVPL-----------ELQM------TRQMASSGASGGK-------------IDNSVLVLIVGLSTV-GAG-AYAYKTMKEDEKRYNERISG M_mulatta_ENSMMUP00000006568 ---------------------PGNLFQRWHVPL-----------ELQM------TRQMASSGASGGK-------------IDNSVLVLIVGLSTV-GAG-VYAYKIIKEDEKRYNERISG E_caballus_ENSECAP00000002768 ---------------------PGNLFQRWHVPL-----------ELQM------TRQMASSGASGGK-------------IDNSVLVLFVGLSTI-GAG-AYAYKTIKDDKKRYNERISG C_familiaris_ENSCAFP00000027660 ---------------------PGNLFQRWHVPL-----------ELQM------ARQMASSGASGGK-------------IDNSVLVLIVGLSTI-GAG-AYAYKTIKDDQKRYDERMSG B_taurus_ENSBTAP00000008987 ---------------------PGNLFQRWHVPL-----------ELQM------TRQMASSGPSGGK-------------IDNSVLVLIVGLSTI-GAG-AYAYKTIKDDKKRYNERISG P_pygmaeus_ENSPPYP00000023188 ---------------------PGNLFQRWHVPL-----------ELQM------TRQMASSGASGGK-------------IDNSVLVLIVGLSTV-GAG-AYVSRKAACIKKLPNRESS- R_norvegicus_ENSRNOP00000008503 ---------------------PGNLFQQWRVPL-----------ELQM------ARQMASSGPSGGK-------------MDNSVLVLIVGLSTI-GAG-AYAYKTIKEDQKRYNERIMG M_musculus_ENSMUSP00000041104 ---------------------PGNLFQQWRVPL-----------ELQM------ARQMASSGSSGGK-------------MDNSVLVLIVGLSTI-GAG-AYAYKTIKEDQKRYNERVMG M_domestica_ENSMODP00000027578 ---------------------PGNLLQRWHIPV-----------EFQM------TRQMASSGASGNK-------------IDKSMLVLIVGLSSM-GAG-AYAYMTVKEDQKRYDERISG P_troglodytes_ENSPTRP00000038338 ---------------------PGNLFQRWHVPL-----------ELQM------TRQMASSGASGGK-------------IDNSVLVLIVGLSTV-GAG-AYAYKTMKEDEKRYNERISG O_cuniculus_ENSOCUP00000002538 ---------------------PGNLFQRWHVPL-----------ELQM------TRQMASSGASGGK-------------IDNSVLVLIVGLSTI-GAG-AYAYKTIKDDKKRYDERMSG A_carolinensis_ENSACAP00000008812 ---------------------PGLLCQRWKVPL-----------EVQL------SRHMASSGAPGGK-------------SENIVFALLVGFSTL-GAG-AYVYKTLKEDKERYNERIAS T_guttata_ENSTGUP00000005365 ----------------------GTLLQRWNVPP-----------DLQL------SRQVASKGVPGQK-------------GSNSVFVLIMGLSTL-GAG-AYVYKTLQDSKERYASRLA- G_gallus_ENSGALP00000006366 ---------------------PLSSVQRGRAAA-----------VLQCHHLRYPSRALTSSGVPGKA-------------GSNLLLYLIVGGTVT-GAG-AYVYKTLRENKERFTSRVTT X_tropicalis_ENSXETP00000039440 ---------------------AGDFLHQQSLLP-----------HQTF------RNAGGPAGVPGPG-------------GDSSLYALIVGVSAL-GAG-IYVYRTLQGDKARFRERNSY D_rerio_ENSDARP00000075330 ---------------------HGRRLE-------------------MV------QRAQMSSGPPGGG-------------GENAVYFVLVGAACL-GGG-IYAYRTVSQDSERYNERMRQ T_rubripes_ENSTRUP00000030183 ---------------------TG--LNNARIPV-----------REPA--------VHMSTGPTGGG-G-----------RENLLYFAMVGTTFI-GAG-IYVYRTLKEDKERYQDRINE T_nigroviridis_ENSTNIP00000014785 ---------------------TG--LNNAKTPT-----------CAPA--------ARMSTGSTGGGEG-----------RENLLYFAVIGTTCV-GAG-IYVYRTLKQDKERYQDRINV G_aculeatus_ENSGACP00000026857 ---------------------AG--LNNGRLPA-----------CVPA--------AHMSTAPAGGG-------------RENQLYVLLVGATCV-GGA-IYAYRTVKGDSQRYQDRIDE O_latipes_ENSORLP00000012070 ---------------------AG--LNNGRTPV-----------CVPA--------AHMSSGPVGGG-------------GDNLKYALLVGAVSV-GGL-VYAVVTMKSDQKRYEQRIEE G_gorilla_ENSGGOP00000007470 ---------------------PXXXXXXXXXXX-----------XXXX------XXXXXXXXXXXXX-------------XXXXXXXXXXXXSTV-GAG-AYXXXXXXXXXXXXXXXXXX C_intestinalis_ENSCINP00000012225 ---------------------IVSRYQDQVTPV-----------HCKQNRAFYSQKATFHSDQSSN---------------YGSGFCIIGGTLFF-GIG---IYKYLTESKANAAE---- A_gambiae_AGAP008044-PA ---------------------PYPAPPRRHIPI-----NRFFQQTEQKAIAATGGPTCPPPPPPPPK------------PSYTGYILGAIALTAG-GLGLAYYNGLFDGPPPP--TPVDD A_aegypti_AAEL002016-PA QM-------------------PPKTRPKRSAPE-----------REESLSAKASAPACPPPPPPGQN-------------STNSYIFGAIALTAG-GLGLAYAMGLFDGKESPMVEKAEP T_guttata_ENSTGUP00000016816 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0077504 PLFKVGFADVKSVCSAKDVLKSDSAKLSTSQPVLDSCKATSPCEEFKRKRKETTCQPCDEDGTAPGG-GDGGDEECECRMKDLRLKCLLGALAAL-LAG-GFLAWFMTRDTDDSEAKKA- C_elegans_Y56A3A.32.1 HEQKHEEKEHAEPEKKEEAKPEKPAEPKEPEPA----------QKQAEQPEQAEEKQETKDAEPKEQ-------------VDDRQTEEAVHARRAPAAAEEPAPSTSKAD-AVEEKRSEQ O_anatinus_ENSOANP00000025948 ---------------------PGPSWRRWNGPL-----------------ELTPASQMSTSGPPGGR-------------VNSSGLFLFVGLSAL-GAGAYTASPTRGRDRVRPDELPQR P_pygmaeus_ENSPPYP00000013415 LSTPHPYPSPQDCVE--AAVCHVKDLENGQMREVELGW-GKVLLVKDNGEFHALGHKCPHYGAPLVK-GVLSRGRVRCPWHGACFNISTGDLEDFPGLDSLHKFQVKIEK-EKVYVRASK P_troglodytes_ENSPTRP00000024275 LSTPHPYPSPQDCVE--AAVCHVKDLENGQMREVELGW-GKVLLVKDNGEFHALGHKCPHYGAPLVK-GVLSRGRVRCPWHGACFNISTGDLEDFPGLDSLHKFQVKIEK-EKVYVRASK H_sapiens_ENSP00000382120 LSTPHPYPSPQDCVE--AAVCHVKDLENGQMREVELGW-GKVLLVKDNGEFHALGHKCPHYGAPLVK-GVLSRGRVRCPWHGACFNISTGDLEDFPGLDSLHKFQVKIEK-EKVYVRASK T_guttata_ENSTGUP00000010972 PIASNPYHNPKDVVE--ASVCHVKDLENGQMREVDLGC-GKALLIKESGEFHAVGHKCPHYGAPLVK-GVLSKGRVRCPWHGACFNISTGDIEDFPGLDSLPRFQVKIEK-EKVYIRASK M_mulatta_ENSMMUP00000026974 LPTPHPYPSPQDCVE--AAVCHVKDLENGQMREVELGW-GKVLLVKDNGEFHALGHKCPHYGAPLVK-GVLSRGRVRCPWHGACFNISTGDLEDFPGLDSLHKFQVKIEK-EKVYVRASK A_carolinensis_ENSACAP00000010903 PVALNPYRNLKDVVE--ASVCYVKDLDNGQMREVDLGC-GKALLVKENGEFYAMGHKCPHYGAPLVK-GVLSKGRIRCPWHGACFNIGTGDIEDFPGLDSLPKFQVKIEK-EKVYIRASK T_nigroviridis_ENSTNIP00000021125 ----NQQVQEEDELT--EMVCQESELKDGQMKEVTVGE-KKVLLVCSQGRYSAVGSQCSHYNAPLVK-GALFGERVRCPFHGACFNVRTGDIEEYPGLDSLPSYKVKVEN-GMVYVTVQK C_intestinalis_ENSCINP00000015763 --------SKDEIVE--AYACKVGEMKDGEMREVSVGD-GKALLVRHQGEYSAIGHKCTHYGAPLVK-GALRDGRVRCPWHGACFNAKTGDIEDFPGLDCVPKHNIVIQDGDKVVIRACK B_taurus_ENSBTAP00000053272 LPTAHPYPGAQDCVE--AAVCHVKDLENGQMREVELGW-GKVLLVKDNGELHALGHKCPHYGAPLVK-GVLSRGRVRCPWHGACFNVSTGDLEDFPGLDSLHKFQVKIEK-EKVYIRASK O_latipes_ENSORLP00000009976 SSLLPLNFKTRDYVE--ACVCHIKDLENGQMREVDLGS-GRALLIKEHGEFFAMGHKCPHYGAPLVK-GVLSKGHVRCPWHGACFNVATGDIEDFPGLDSLPVFQVRVEK-EKVIIRANK G_gallus_ENSGALP00000012503 PIASNPYHNPKDVVE--ASVCHVKDLENGQMREVDLGC-GKALLIKEGGEFYAMGHKCPHYGAPLVK-GVLSKGRVRCPWHGACFNIGTGDIEDFPGLDSLPRFQVKIEK-EKVYIRASK D_rerio_ENSDARP00000085557 SMTLRPQRKNRDYIE--ASVCHIKDLENGQMREVDLGA-GRALLIKEHGEFFAMGHKCPHYGAPLVK-GVLSKGHVRCPWHGACFNIATGDIEDFPGLDSLPTFQVRVEK-EKVIIRANK M_musculus_ENSMUSP00000111349 LPTPQPYPSPQDCVE--ATVCHVKDLENGQMREVELGW-GKVLLVKDNGEFHALGHKCPHYGAPLVK-GVLSRGRVRCPWHGACFNISTGDLEDFPGLDSLHKFQVKIEK-EKVTIRASK G_gallus_ENSGALP00000039047 PLPVSINMDCNDTVT--AEVCREDDIGDGELCEVMVAG-YPVLLVRDKMEFSALGSRCPHYGAPLSK-GVLRGHRLRCPWHGSCFNIKTGDIEEYPSLDCLPCFKVTVED-GKVFVTAKK O_latipes_ENSORLP00000010037 ELQDAGQRGEQEEVT--ELVCPEADLHDGQMKEVTVQD-QKVLVVRTQGQYFAVGGRCSHYNAPLIK-GALVGERVRCPFHGACFNVRTGDIEDYPGLDSLPTYKVKVED-GKVYVSINQ R_norvegicus_ENSRNOP00000048427 LPTPQPYPSPQDCVE--ATVCHVKDLENGQMREVELGW-GKVLLVKDNGEFHALGHKCPHYGAPLVK-GVLSRGRVRCPWHGACFNIGTGDLEDFPGLDSLHKFQVKIEK-EKVTVRASK T_rubripes_ENSTRUP00000040612 ----------EDELT--EMVCQETDLKDGQMKEVMVGE-KKVLLVCSQGQYSAIGSQCSHYNAPLVK-GTLVGQRVRCPFHGACFNVRTGDIEEYPGLDSLPTYKVKVEN-GMVYVTVNK G_aculeatus_ENSGACP00000012379 STPPPLYHKARDYVE--ASVCHVKDLENGQMREVDLGS-GRALLIKEHGEFSAMAHKCPHYGAPLVK-GVLSKGHVRCPWHGACFDIATGDLEDFPGLDSLPTFQVRVEK-DKVIIRANK T_nigroviridis_ENSTNIP00000018986 ATPLVLYHKPREYVE--ASVCHVKDLENEQMREVDLGS-GRALLIKQRGEFSAIGHKCPHYGAPLVK-GVLSKGHVRCPWHGACFNIATGDIEDFPGLDSLPTFQVRVEK-DKVIIRANK G_aculeatus_ENSGACP00000011210 PGQGAEEQQEEEEVT--GMVCQEVDLRDGQMKEVTVGD-QKVLLVRTRGQYSAVGSQCSHYNAPLVK-GVLVGDRVRCPFHGACFNVRTGDIEEYPGLDCLPSYKVKVED-GKVYVSIHK T_guttata_ENSTGUP00000005877 -----------------------------------------VLLVRNRREFRALGSKCPHYGAPLSK-GVLRGERLRCPWHGACFNIRTGDIEEYPALDCISCFKVTVED-GKVFITAKK D_melanogaster_FBpp0080714 --------EENEYIDP-VVVCHKLEVQENEMRQVDASGIPSILLVKQSGILRAVGAMCPHRGAPLAK-GVLSRNRVRCPWHGVCFNLETGDIENFPGLDSLPCHRVNVDSRGQVLVQVKR T_rubripes_ENSTRUP00000040932 STPLALYHKPREYVE--VSVCHVKDLENEQMREVDLGS-GRALLIKQRGEFSAIGHKCPHYGAPLVK-GVLSKGHVRCPWHGACFNIATGDIEDFPGLDSLPTFQVRVEK-DKVIIRANK X_tropicalis_ENSXETP00000057179 PIVLNPYTNPKDVVE--ASVCHVKDLENGQMREVDLGC-GKALLVKQNGEYYAMGHKCPHYGAPLVK-GVLSKGRVRCPWHGACFNIATGDIEDFPGLDALPKFQVKIEK-ERVYIRASK A_carolinensis_ENSACAP00000014484 ------------------------------MREVDVAG-WPVVLVKEGTRFWAVGGRCPHAGGPLSK-GYLSRGRLRCPWHGACFSVQTGDIEEFPTLDCLPAFKVSVDE-GQVYVTAKL O_latipes_ENSORLP00000003241 -----------------------------RMKEVEIGH-HSVLLTRHEGKYSALGNQCTHYGAPLSQ-GVVSGNRVRCPWHGSCFNICTGDLEEFPGIDSLPCHKVKIQN-SKVYVTVNR G_aculeatus_ENSGACP00000027082 -------------------VCLESDLQDGQMMEVEVGQ-HSVLLSRTEGEYSAIGNQCTHYGAPLSQAGVISGNTVRCPWHGACFNIHTGDLEEYPGMDCLPCHKVKIQN-NKVYVSVNK T_nigroviridis_ENSTNIP00000019217 ------------------AVCLESELQDGQMMEVEVGH-HSVLLTHCEGKFSAIGNQCTHYGAPLSKAGAITGHTVRCPWHGACFNVHTGDLEEYPGIDSLPCHKVRIHN-SQVYVSVNK C_elegans_F20D6.11 PVEPECDNDDSPAVE--EILGRIEDVPPGTKKMFEVRD-RKVLVINDEGRIYAINGLCSHYNFSLEN-GTYAKGRIRCPLHGACFNVRSGDIEDYPGFDSLHSYVVTVND-GNLIIKTTE T_rubripes_ENSTRUP00000030429 ------------------AVCLESELQEGQMMEVEVGH-HSVLLTHCEGKFSAIGNQCTHYGAPLSK-GAVTGHTVRCPWHGACFNVHTGDLEEYPGIDSLPCHKVRIHN-SKVYVSVNK D_melanogaster_FBpp0070319 TMSTEESSPDSEYTSAVPVDCRVTDLKENEMKQVDFDEDTRVLLVKQNDRLLAVGAKCTHYGAPLQT-GALGLGRVRCPWHGACFNLENGDIEDFPGLDSLPCYRVEVGNEGQVMLRAKR A_aegypti_AAEL011158-PA --VTGGASPDGGYVE--DFICNENDIGENEMKAFEVDG-GKVLLVKQKGKLSAIGNKCSHYGALLST-GALGEGRVRCPWHGACFNIETGDIEDFPGQDSLPCFKVTVEQ-GRVKIRAKR 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000287295 LGLTPEQKQKKAAL---------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000006568 LGLTPEQKQKKAAL---------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000002768 LGLTPEEKQKRATS---------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000027660 LGLTPEEKQKRATS---------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000008987 LGLTPEEKQKRATS---------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000023188 -ETSRRFIQSVLLL---------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000008503 LGLSPEEKQRRAIA---------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000041104 LGLSPEEKQRRAIA---------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000027578 LGLTPEEKERRDSL---------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000038338 LGLTPEQKQKKAAL---------------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000002538 LGLTPEEKQKRATA---------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000008812 LGQRPSQDAEPSAA---------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000005365 --RTSRQSQDSAAP---------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000006366 VTTRSQEKESSPSA---------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000039440 LSRRQTDLKEEVKATETIDEQK-------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000075330 IASRQSQESKPAKALAEVAESKEELEPVAEEPTLIEPAVEESPVTEDIVESPEAVAEPIV-KSSIPEPAVEIAVTEPVVEASVPESVI---------------ESPLMEPVVEASVQEPI T_rubripes_ENSTRUP00000030183 IASRPQKAAAKEAT-----------------------LLHPEPQVTCSHGNIFYSTNNSLFFTTFYFLAVEATETKGNLNASSTEILF---------------AAPETEPQAEPAVGEP- T_nigroviridis_ENSTNIP00000014785 IASRPKKAAVNEAT-----------------------VPQPEPHAAEATETKGESTDNVI------KQKRKCTEKRNHFIISFARTMLSVLPEPVNCYCFPPSADPETEPAAEPAAVEP- G_aculeatus_ENSGACP00000026857 ISSRPLKTFTEEPA------TPTQSEPP----------------AAPSPAEPSPPAPDAE-ILAP-----IETADLP--------------------------------------SDEPV O_latipes_ENSORLP00000012070 LSTRPQKTSTIPTA------AQIQSEPPVKETALVQAVPEDQPAAAPSIEEPSSPAE----VEAPKEETAPETTTPPGITSSKIHYMI---------------CPPLSEKWIASTADEPV G_gorilla_ENSGGOP00000007470 XXXXXXXXXXXXXX---------------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000012225 -ARTQDESVEQAT----------------------------------------------------------------------------------------------------------- A_gambiae_AGAP008044-PA TKEDADRKKRTY------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL002016-PA TVAEQPKKKTKLPF---------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000016816 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0077504 -EAEEEERKRRLVA---------------------------------------------------------------------------------------------------------- C_elegans_Y56A3A.32.1 QSMKPSESTEENT----------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000025948 FELSPLEKSPRA------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000013415 QALQLQRRTKVMA----------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000024275 QALQLQRRTKVMA----------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000382120 QALQLQRRTKVMA----------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000010972 QTLQTQRRTKMMA----------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000026974 QALQLQRRTKVMA----------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000010903 QALQTQRRTKVMG----------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000021125 HSLKLTKRVKEMC----------------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000015763 SALETHKRYKPMV----------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000053272 QALQLQRRTKVMA----------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000009976 QALQTQKRSKPMA----------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000012503 QALQTQRRTKMMA----------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000085557 QALQTQRRSKVMS----------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000111349 QALQLQRRTKVMA----------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000039047 KDLESSLRVKDMS----------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000010037 KSLKLTKRVKEMC----------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000048427 QALQLQRRTKVMA----------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000040612 HALKLTKRVKEMC----------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000012379 QALQSQKRSKPMA----------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000018986 QALQAQRRSKAMA----------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000011210 NSLKLTKRVKEMC----------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000005877 KVLTLPAVTEHRQ----------------------------------------------------------------------------------------------------------- D_melanogaster_FBpp0080714 SYLLRHARIKSMA----------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000040932 QALQSQRRSKAMA----------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000057179 QSLHTMHWDKHLC----------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000014484 KDLERSRRLKLMS----------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000003241 KDLKQQKRIRSMG----------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000027082 KTLKQEKRVKRMG----------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000019217 KTLRQEKRIKNMG----------------------------------------------------------------------------------------------------------- C_elegans_F20D6.11 KKLGSDRRIRHLP----------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000030429 KTLRQEKRIKTMG----------------------------------------------------------------------------------------------------------- D_melanogaster_FBpp0070319 SDLVNNKRLKNMV----------------------------------------------------------------------------------------------------------- A_aegypti_AAEL011158-PA SELQSGKRTKAMV----------------------------------------------------------------------------------------------------------- 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000287295 -----------------------------------------------------------------------SASEGEEVPQDKAPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGAR M_mulatta_ENSMMUP00000006568 -----------------------------------------------------------------------SASEGEEVPQDRVPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGAR E_caballus_ENSECAP00000002768 -----------------------------------------------------------------------SAPEGEPVPHVRVPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGAR C_familiaris_ENSCAFP00000027660 -----------------------------------------------------------------------PAPEGEPVPQVRVPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGAR B_taurus_ENSBTAP00000008987 -----------------------------------------------------------------------SALEGEPEPQVRIPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGAR P_pygmaeus_ENSPPYP00000023188 -----------------------------------------------------------------------SASEGEEVPQDKAPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGAR R_norvegicus_ENSRNOP00000008503 -----------------------------------------------------------------------SAAEGGSVPPIRVPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGAR M_musculus_ENSMUSP00000041104 -----------------------------------------------------------------------SATEGGSVPQIRAPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGAR M_domestica_ENSMODP00000027578 -----------------------------------------------------------------------SVPE--TRAQIKAPTHAPFLLIGG-----GTAAFAAA-RSIRARDPGAR P_troglodytes_ENSPTRP00000038338 -----------------------------------------------------------------------SASEGEEVPQDKAPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGAR O_cuniculus_ENSOCUP00000002538 -----------------------------------------------------------------------SAPEGEPVSQVRVPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGAR A_carolinensis_ENSACAP00000008812 -------------------------------------------------------------------------PAAEAAPLPEFPSHVPFLLIGG-----GTAAFAAA-RSIRARDPAAR T_guttata_ENSTGUP00000005365 -----------------------------------------------------------------------QDTAGKFCPHPKVPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGAR G_gallus_ENSGALP00000006366 -----------------------------------------------------------------------------PEARPEVPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGAR X_tropicalis_ENSXETP00000039440 ---------------AVKEVEATGMVDNQ------------------------------------------TPQTVESAHPAQLPSHVPFLLIGG-----GTASFAAA-RSIRARDPGAR D_rerio_ENSDARP00000075330 IEATATETVAEAPEVIQSEEPIAPVVESEPVPVVST----EHVPEASSVSESVFLFWPAAAPETSPAAAPAAEPIDPTAPHLDVLEHAPYLLIGG-----GTASFAAA-RSIRARDPGAR T_rubripes_ENSTRUP00000030183 -----------SPATPDSEAPVAPSETAEPAPALKF----EPQPLATAASPRADL-----TDPSPALTRASASLKTTFPHTFRLPSHTPYLLIGG-----GTASFAAA-RSIRARDPGAR T_nigroviridis_ENSTNIP00000014785 -----------SPAAPGAEAPAASSETAEPVPESATVNMRQWAALSQASAARETF----AFHPCGPVAPAAA--SDSPVVEHKLPSHTPYLLIGG-----GTASFAAA-RSIRARDPGAR G_aculeatus_ENSGACP00000026857 IEASPEEAAEP---PVVE---PEPSPPSEPTPAELT----EPVADSESPAAES----AAAAKPAEPQLEAVTESGDASPASHKVSSHTPYLLIGG-----GTASFAAA-RSIRARDPGAR O_latipes_ENSORLP00000012070 VEGSPEEAAAAAAVPVVQEALTEPLVSSEPPPA--V----ESVVLAEPAAAE-----PPASEPPEPQPEVLVESADSTPVSLKLPAHAPYLLIGG-----GTASFAAA-RSIRARDPGAK G_gorilla_ENSGGOP00000007470 -----------------------------------------------------------------------XXSEGEEVPQDKAPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGAR C_intestinalis_ENSCINP00000012225 ------------------------------------------------------------------------EDVFGVPPAAEFPSQVQYLLIGG-----GTASYAAM-RAIKKRDVTAK A_gambiae_AGAP008044-PA -----------------------------------------------------------------------------PASSKDLPKHVPYLLVGG-----GTASIAAF-RAIRVHDPKAK A_aegypti_AAEL002016-PA -----------------------------------------------------------------------------PASSKDLPSEVPYLLIGG-----GTASFAAF-RAIKGHDAKAK T_guttata_ENSTGUP00000016816 -------------------------------------------------------------------------------PHPKVPSHVPFLLIGG-----GTAAFAAA-RSIRARDPGAR D_melanogaster_FBpp0077504 ------------------------------------------------------------------------GLATSPPSSEDLPKHVPYLIIGG-----GTAAFSAF-RAIKSNDATAK C_elegans_Y56A3A.32.1 -----------------------------------------------------------------------------TTTSADGLLHCEYVIIGS-----GTAAYYAS-LSIRAKQAEAK O_anatinus_ENSOANP00000025948 --------------------------------------------------------------------------------DESQRSETTCPRSHG-----RQAAEAAG-LEPRPRDFPRE P_pygmaeus_ENSPPYP00000013415 ---------------------------------------------------------------------------KCISPSAGYSSSTNVLIVGA-----GAAGLVCA-ETLRQEGFSDR P_troglodytes_ENSPTRP00000024275 ---------------------------------------------------------------------------KCISPSAGYSSSTNVLIVGA-----GAAGLVCA-ETLRQEGFSDR H_sapiens_ENSP00000382120 ---------------------------------------------------------------------------KCISPSAGYSSSTNVLIVGA-----GAAGLVCA-ETLRQEGFSDR T_guttata_ENSTGUP00000010972 ---------------------------------------------------------------------------KCISLSNYNLSSTNVLIIGA-----GAAGLVCA-ETLRQEGFSDR M_mulatta_ENSMMUP00000026974 ---------------------------------------------------------------------------KCISPSAGYSSSTNVLIVGA-----GAAGLVCA-ETLRQEGFSDR A_carolinensis_ENSACAP00000010903 ---------------------------------------------------------------------------KCISLSNYSISSTNVLIIGA-----GPAGLVCA-ETLRQEGFSDR T_nigroviridis_ENSTNIP00000021125 --------------------------------------------------------------------------------SRKPDIKHTILLIGG-----GPAALVCA-ETLRQNCYEGR C_intestinalis_ENSCINP00000015763 --------------------------------------------------------------------------------QTQNEDGPHVVIVGG-----GPASVTCA-ETLRQKSFLGK B_taurus_ENSBTAP00000053272 ---------------------------------------------------------------------------TCISPSAGYSGSTNVLIVGA-----GAAGLVCA-ETLRQEGFSDR O_latipes_ENSORLP00000009976 ---------------------------------------------------------------------------RCSSVIHSNTGFSHVLIIGS-----GPAALVCA-ETLRQEGFTDR G_gallus_ENSGALP00000012503 ---------------------------------------------------------------------------KCISLSNYNLSSTNVLIIGA-----GAAGLVCA-ETLRQEGFSDR D_rerio_ENSDARP00000085557 ---------------------------------------------------------------------------KCSAVINSSTGFSHVLIIGS-----GPAGLVCA-ETLRQEGFTDR M_musculus_ENSMUSP00000111349 ---------------------------------------------------------------------------KCISPSAGHSSSTNVLIVGA-----GAAGLVCA-ETLRQEGFSDR G_gallus_ENSGALP00000039047 --------------------------------------------------------------------------------KRCLLNRNTMLLLGG-----GVAALTCA-ETLRQEGFTGR O_latipes_ENSORLP00000010037 --------------------------------------------------------------------------------TLEPGAKHTVLLVGG-----GPASLVCA-ETLRQNCYQGR R_norvegicus_ENSRNOP00000048427 ---------------------------------------------------------------------------KCISPSAGH-SSTNVLIVGA-----GAAGLVCA-ETLRQEGFSDR T_rubripes_ENSTRUP00000040612 --------------------------------------------------------------------------------SRIADIKHTILLIGG-----GPAALVCA-ETLRQTCYEGR G_aculeatus_ENSGACP00000012379 ---------------------------------------------------------------------------RCSAVINSSSGFSHVLIIGS-----GPAGLVCA-ETLRQEGFTDR T_nigroviridis_ENSTNIP00000018986 ---------------------------------------------------------------------------RCSAVINASTGFSHILIIGS-----GPAGLLCA-ETLRQEGFTDR G_aculeatus_ENSGACP00000011210 --------------------------------------------------------------------------------TREPDIQHTTLLIGG-----GPASLVCA-ETLRQNCYQGR T_guttata_ENSTGUP00000005877 ----------------------------------------------------------------------------CLGLRRCLLNRNTMLLLGG-----GVAALVCA-ETLRQEGFTGR D_melanogaster_FBpp0080714 --------------------------------------------------------------------------------CRNWQDQRHFVVVGG-----GPSGAVCV-ETLRQEGFTGR T_rubripes_ENSTRUP00000040932 ---------------------------------------------------------------------------RCSAVINSSTGFSHVLIIGS-----GPAGLVCA-ETLRQEGFTDR X_tropicalis_ENSXETP00000057179 ---------------------------------------------------------------------------YKMTLRMNKKKITLIVILNAYIL--QTFGVISSTEIKKQKIFFAY A_carolinensis_ENSACAP00000014484 --------------------------------------------------------------------------------KRDPLDPRTVLLLGA-----GPASLTCA-ETLRQEGFSGR O_latipes_ENSORLP00000003241 --------------------------------------------------------------------------------GAVPGVAHTILLLGG-----GIASLMCA-ETLRQEKFGGR G_aculeatus_ENSGACP00000027082 --------------------------------------------------------------------------------AAVAGVTHTVLLLGG-----GAASLICA-ETLRQENFGGR T_nigroviridis_ENSTNIP00000019217 --------------------------------------------------------------------------------AAVLGFTHTVVLLGGGCVNAGAASLICA-EVLRQENFPGR C_elegans_F20D6.11 --------------------------------------------------------------------------------KMKQCNDRPVVIIGG-----GVATATFI-EHSRLNGLITP T_rubripes_ENSTRUP00000030429 --------------------------------------------------------------------------------AAVPGFTHTVVLLGG-----GAASLICA-EVLRQQNFPGR D_melanogaster_FBpp0070319 --------------------------------------------------------------------------------RRKPDDQRVFIVVGG-----GPSGAVAV-ETIRQEGFTGR A_aegypti_AAEL011158-PA --------------------------------------------------------------------------------KKEKEDERTFVVIGG-----GPSGAICA-EALRQEGFTGR 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000287295 VLIVSEDPELPYMRPPLSK--EL-----WFS-DDPN--VTKTLRFKQWNGKERSIYFQPPS-FYVSAQDLPHIENGGVAVLTGKKVVQLDVRDNMVKLNDGSQITYEKCLIAT-GGT--- M_mulatta_ENSMMUP00000006568 VLIVSEDPELPYMRPPLSK--EL-----WFS-DDPN--VTKTLRFKQWNGKERSIYFQPPS-FYVSAQDLPHIENGGVAVLTGKKVVQLDVRGNMVKLNDGSQITYEKCLIAT-GGT--- E_caballus_ENSECAP00000002768 VLIVSEDPELPYMRPPLSK--EL-----WFS-DDPN--VTKTLRFRQWNGKERSIYFQPPS-FYVSAEDLPHIENGGVAVLTGKKVIQLDVRGNMVKLNDGSQITYEKCLIAT-GGT--- C_familiaris_ENSCAFP00000027660 VLIVSEDPELPYMRPPLSK--EL-----WFS-DDPN--VTKTLRFRQWNGKERSIYFQPPS-FYVAAQDLPHIENGGVAVLTGKKVVHLDVRGNMVKLNDGSQITYEKCLIAT-GGT--- B_taurus_ENSBTAP00000008987 VLIVSEDPELPYMRPPLSK--EL-----WFS-DDPN--VTKTLRFKQWNGKERSIYFQPPS-FYVSAQDLPRVENGGVAVLTGKKVVQLDVRGNVAKLNDGSQITYEKCLIAT-GGT--- P_pygmaeus_ENSPPYP00000023188 VLIVSEDPELPYMRPPLSK--EL-----WFS-DDPN--VTKTLRFKQWNGKERSIYFQPPS-FYVSAQDLPHIENGGVAVLTGKKVVQLDVRDNMVKLNDGSQITYEKCLIAT-GGT--- R_norvegicus_ENSRNOP00000008503 VLIVSEDPELPYMRPPLSK--EL-----WFS-DDPN--VTKTLQFRQWNGKERSIYFQPPS-FYVSAQDLPHIENGGVAVLTGKKVVHLDVRGNMVKLNDGSQITFEKCLIAT-GGT--- M_musculus_ENSMUSP00000041104 VLIVSEDPELPYMRPPLSK--EL-----WFS-DDPN--VTKTLQFRQWNGKERSIYFQPPS-FYVSAQDLPNIENGGVAVLTGKKVVHLDVRGNMVKLNDGSQITFEKCLIAT-GGT--- M_domestica_ENSMODP00000027578 VLIISEDPELPYMRPPLSK--EL-----WFS-DDPN--VTNTLRFKQWNGKERRYASRSTR-WWTRARSWVPMISWEV-LISEEFVVQLDVRDNMVKLNDGSQITFEKCLIAT-GGT--- P_troglodytes_ENSPTRP00000038338 VLIVSEDPELPYMRPPLSK--EL-----WFS-DDPN--VTKTLRFKQWNGKERSIYFQPPS-FYVSAQDLPHIENGGVAVLTGKKVVQLDVRDNMVKLHDGSQITYEKCLIAT-GGT--- O_cuniculus_ENSOCUP00000002538 VLIVSEDPELPYMRPPLSK--EL-----WFS-DDPN--VTKTLRFKQWNGKERXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXVVQLDVRGNMVKLNDGSQITYEKCLIAT-GGT--- A_carolinensis_ENSACAP00000008812 VLIVSEDPEFPYMRPPLSK--EL-----WFS-EDPD--VTETLRFKQWNGKERSIYFQPPS-FYVSPRDLPHIENGGVAVLSGRKVVHMDVRGNVVTLDNGTQISYDKCLLAT-GGS--- T_guttata_ENSTGUP00000005365 VLIVSEDPALPYMRPPLSK--EL-----WFS-DDPN--VTETLRFKQWNGKERSIYFQPPS-FYVPVEDLPSVENGGVAVLPGKKVVHMDVRGNTVKLNDGTQISYDKCLIAT-GGS--- G_gallus_ENSGALP00000006366 VLIVSEDPALPYMRPPLSK--EL-----WFS-DDPH--VTETLRFKQWNGKERSIYFQPPS-FYVHARDLPFVENGGVAVLSGKKVVHMDVRGNTVKLNDGTQISYDKCLIAT-GTI--- X_tropicalis_ENSXETP00000039440 VLIVSDESELPYMRPPLSK--EL-----WFS-EDPH--VTETLRFKQWNGKERSIFFQPPS-FYVPPEQLMSVENGGVSVLTGKKVVHMDVRENKVKLDDGTQISYEKCLIAT-GGV--- D_rerio_ENSDARP00000075330 VLIITEESDLPYMRPPLSK--EL-----WFS-DDPK--VTESLRFKQWNGKERSIYFQPPS-FYVSPADLAKVENGGVAVLTDSKVVHMDVRGNKVKLSDGSEISYEKCLIAT-GGV--- T_rubripes_ENSTRUP00000030183 VLIVTDEPDLPYMRPPLSK--EL-----WFS-DDPS--VTETLRFKQWNGKERSIYFQPAS-FYISAEELDSAENGGVAVLTGKKVVHMDVRGNKVKLDDDTEISYDKCLIAT-GGV--- T_nigroviridis_ENSTNIP00000014785 VLIVTDEPDLPYMRPPLSK--EL-----WFS-DDPS--VTETLRFKQWNGKERSIYFQPAS-FYISAEELDSAENGGVAVLPGKKVVHMDVRGNKVKLDDNTEISYDKCLIAT-GGV--- G_aculeatus_ENSGACP00000026857 VLIVTDELVPPYMRPPLSK--EL-----WFS-DDPS--VTETLRFKQWNGKERSIYFQPPS-FYINAEELGSAENGGVAVLTGKKVVHMDVRGNKIKLDDDTEISYDKCLIAT-GGV--- O_latipes_ENSORLP00000012070 VLIVTDEPDLPYMRPPLSK--EL-----WFS-DDPA--VTDTLRFKQWNGKERSIYFQPPS-FYIRPEDLDGAENGGVAVLNNRKVVYMDVRGNKVKLDDDTEISYDKCLIATAGGI--- G_gorilla_ENSGGOP00000007470 VLIVSEDPELPYMRPPLSK--EL-----WFS-DDPN--VTKTLRFKQWNGKERXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXVVQLDVRDNMVKLNDGSQITYEKCLIAT-GGT--- C_intestinalis_ENSCINP00000012225 ILIISEDSYPPYMRPPLSK--EL-----WYS-DDEE--AAKKLQFKSWNGKWRDVYFEKPD-YYCAPSDLPAKSEGGVAVANNTRVVSLNPTDNIATLKDGTEIKYDKCLIAT-GGQ--- A_gambiae_AGAP008044-PA VMMITNELEMPYMRPPLSK--EL-----WFN---PT--EAEPLKFRQWNGSERSIFYEPND-YYIDPSKLSDAPNGGVAVARGYEVHRLDVVNRKAILTDGTEISYDKCLIAT-GAR--- A_aegypti_AAEL002016-PA VLVITNETELPYMRPPLSK--EL-----WFNPEDKA--QLEPLKFRQWNGVERSIYFEPDD-FYIDPTKLMESPNGGVAIARGYEVQRIDVVNRKAILTDGTEIKYGECLLAT-GAR--- T_guttata_ENSTGUP00000016816 VLIVSEDPALPYMRPPLSK--EL-----WFS-DDPN--VTETLRFKQWNGKERSIYFQPPS-FYVPVEDLP-CENGGVAVLPGKKVVHMDVRGNTVKLNDGTQISYDKCLIAT-GGS--- D_melanogaster_FBpp0077504 VLMISNEFRKPYMRPPLSK--EL-----WYT-PNPNEDPIKDYRFKQWTGSERSLFFEPDE-FFIDPEDLDDNANGGIAVAQGFSVKKVDAQKRIVTLNDGYEISYDECLIAT-GCA--- C_elegans_Y56A3A.32.1 VLMIGEEPELPYNRPPLSK--EL-----WWY-GDET--SATKLAYTPLSGKKRDIFYEVDG-FFVSPEDLPKAVHGGVALLRGRKAVKICEEDKKVILEDGTTIGYDKLLIAT-GVR--- O_anatinus_ENSOANP00000025948 ASQLPGTHRPLQPTPPLSS--SIRPLAFWAS-SLPA--PLPRPPSLSPCVSPPSIYFQPPS-FYVSAQDLPHTENGGVAVLSGRKVVQLDVRANVAKLSDGAQISYEKCLIAT-G----- P_pygmaeus_ENSPPYP00000013415 IVLCTLDRHLPYDRPKLSK--SL-------------------------DTQPEQLALRPKE-FF---------RAYGIEVLTEAQVVTVDVRNKKVVFKDGFKLEYSKLLLAP-GSS--- P_troglodytes_ENSPTRP00000024275 IVLCTLDRHLPYDRPKLSK--SL-------------------------DTQPEQLALRPKE-FF---------RAYGIEVLTEAQVVTLDVRNKKVVFKDGFKLEYSKLLLAP-GSS--- H_sapiens_ENSP00000382120 IVLCTLDRHLPYDRPKLSK--SL-------------------------DTQPEQLALRPKE-FF---------RAYGIEVLTEAQVVTVDVRTKKVVFKDGFKLEYSKLLLAP-GSS--- T_guttata_ENSTGUP00000010972 IVMCTMDRHLPYDRPKLSK--SM-------------------------DSHPEQIALRPKE-FF---------CTYDIEVLTEMQVAAVDVKSKIAVFKDGFKMEYNKLLIAT-GST--- M_mulatta_ENSMMUP00000026974 IVLCTLDRHLPYDRPKLSK--SL-------------------------DTQPEQLALRPKE-FF---------RAYGIEVLTEAQVVTVDVRNKKVVFKDGFKLEYSKLLLAP-GSS--- A_carolinensis_ENSACAP00000010903 IVMCTMDRHLPYDRPKLSK--SM-------------------------DSHADQIALRPKE-FF---------RTYDIEVLTEMQVVAVDVKNKTAVFKDGFKMEYNKLLLAT-GNT--- T_nigroviridis_ENSTNIP00000021125 IVMVTKDTLPPFDKPKLSK--AL-------------------------NLDSGSVLLRSAD-FY---------QQYGIEVWTQKEVVSVDTVDKAVELNDGSSHNYDQLLIST-GCR--- C_intestinalis_ENSCINP00000015763 ITILSADPYLPYDRTKLSK--AM-------------------------DIKPEAIFLRPQE-FY---------DAVNIKIINNKRVNGVNAETQVVTCEDGDTFKYDKLMVAT-GGR--- B_taurus_ENSBTAP00000053272 IVLCTLDRHLPYDRPKLSK--SL-------------------------DAQPEQLALRPKE-FF---------RAHGIEVLTEAQVVTVDVRNKKAVFKDGFKLEYSKLLLAP-GSS--- O_latipes_ENSORLP00000009976 IVMCTMDRHPPYDRPKLSK--SL-------------------------ESTAEQLRLRSVD-FL---------QDHDIELLTEKEVAAVDVKTRTVTFEDGLKMEYRKLFIAT-GSK--- G_gallus_ENSGALP00000012503 IVMCTMDRHLPYDRPKLSK--SM-------------------------DSHPEQIALRPKE-FF---------RTYDIEVLTEMQAAAVDIKNKTAVFKDGFKMEYNKLLIAT-GNT--- D_rerio_ENSDARP00000085557 IVICTTDKHLPYDRPKLSK--SL-------------------------ESTAEQLQLRSSD-FF---------QMHDIEVLLEKEVVSVDVKTHTVTFRDGFKMEYRKLFIAT-GSR--- M_musculus_ENSMUSP00000111349 IVLCTLDRHLPYDRAKLSK--SL-------------------------DAQPEQLALRPKE-FF---------RAYGIEMLTEAQVVTVDVRNKKVVFKDGFKLEYSKLLLAP-GSS--- G_gallus_ENSGALP00000039047 IIMATKEKHAPYDKSKLSK--EM-------------------------NLKAEDIYLRKPE-FL---------CAHGIELWTEKEAASVDFQKQKVHFMDGSSQKYNQLLIAT-GGH--- O_latipes_ENSORLP00000010037 IIMVTKDSLPPYDKTKLSK--VM-------------------------NVESSSLLLRPAE-FY---------QQYGIEVWTNKEVVSVNPGNKLVQINDGALQHYDQLLIST-GCR--- R_norvegicus_ENSRNOP00000048427 IVLCTLDRHLPYDRAKLSK--SL-------------------------DAQPEQLALRPKE-FF---------RAYGIEMLTEAQVVTVDVRNKKVVFKDGFKLEYSKLLLAP-GSS--- T_rubripes_ENSTRUP00000040612 IIMVTRDALPPFDKPKLSK--AL-------------------------HLDRSSILLRSAD-FY---------QQYGIEVWTEKEVISVNTVNKAVKMIDGTWLNYDQLLIAT-GCR--- G_aculeatus_ENSGACP00000012379 IVMCTKDRHPPYDRPKLSK--SL-------------------------ESTAEQLRLRSMD-FL---------QDHDIELLVDKEAVSIDVKTRSVTFEDGSRMEYKKLFIAT-GSK--- T_nigroviridis_ENSTNIP00000018986 IVMCTMDRHPPYDRPKLSK--SL-------------------------ESTAEQLRLRSAD-FL---------RDHDIELITEKEAVLVDVKSRSVTFEDGLKMDYRKLFIAP-GSR--- G_aculeatus_ENSGACP00000011210 IVIVTKDTLPPFDKPKLSK--AL-------------------------DLDSSSILLRPSD-FY---------QQHGVEVWTRKEVVSVDPAEKSVKLSDGSLQRYDQLLIST-GCR--- T_guttata_ENSTGUP00000005877 IIVATNERHVPYDKSKLSK--EM-------------------------NLKAEDVYLRKPE-FL---------QARDIEFWTEKEAVWVDFQKQKVHFMDGSCQKYQQLLIAT-GSH--- D_melanogaster_FBpp0080714 LTLVCGEKHLPYDRTRIMN--LL-------------------------NTYTKNLALREEQ-FY---------KDYGIEMQLGVSAERLDTNCNTLHCTNGKTFPYDKIYIAT-GYS--- T_rubripes_ENSTRUP00000040932 IVMCTMDRHPPYDRPKLSK--SL-------------------------ESTAEQLRLRSAD-FL---------RDHDIELITEKEAVLVDVKSRSVTFGDGLKMDYRKLFIAT-GSRCHA X_tropicalis_ENSXETP00000057179 ISKKELEAILPGDRLAILAFISM-------------------------DSQAEQIFLRSKE-FF---------HTYDIEVLTESQVVGVDTKNKMVLFKDGFRMEYNKLLIAT-GNT--- A_carolinensis_ENSACAP00000014484 IIMVTQEGHLPYDRTKLSK--DI-------------------------GAQAEDILLRPPS-FM---------ETYGIEVWRQKEVVSINPDDKVAQFSDGTSQGYDNLLIAT-GSR--- O_latipes_ENSORLP00000003241 IIMVSRDHLLPYDKTRLSK--VM-------------------------NVESDTIVLRRME-FY---------HQYDIEVWLRKEVLSVDTDRKTVAFDDGLVQNYDQLLIST-GCR--- G_aculeatus_ENSGACP00000027082 IIMVTRDDLLPYDKTRLSK--VM-------------------------NVENDSILLRRSE-FF---------YQHDIEVWLRKEAVSVDTDMKTVAFEDGSVQSYDHLLICS-GVL--- T_nigroviridis_ENSTNIP00000019217 IIMATRDELLPYDKTRLSK--VM-------------------------NVESESILLRRRE-FF---------LQYDIEVWLRKEALSVNTDEKTVTFDDGSVQSYDQLLIAT-GSR--- C_elegans_F20D6.11 ILVISEESLPPYDRVLLSK--KP-------------------------AATGEDIRLRKDDAFY---------EERNVKFLLKTSVIAVNHKSREVSLSNGETVVYSKLIIAT-GGN--- T_rubripes_ENSTRUP00000030429 IIMATRDDLLPYDKTRLSK--VM-------------------------NVETESILLRRME-FY---------LQYDIEVWLRKEAQSVNTDEKTVTFDDGSVQSYDQLLIAT-GCR--- D_melanogaster_FBpp0070319 LIFVCREDYLPYDRVKISK--AM-------------------------NLEIEQLRFRDEE-FY---------KEYDIELWQGVAAEKLDTAQKELHCSNGYVVKYDKIYLAT-GCS--- A_aegypti_AAEL011158-PA VIMINKEPCLPYDRILVSK--TM-------------------------DFDLEKKLLRDEK-FY---------AEHEIETMIGTEVTSLNSANRELTLSNGYKIKYDKVYIAT-GSE--- 610 620 630 640 650 660 670 680 690 700 710 720 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000287295 --PRSLSAIDRAGAEVKSRTTLFRKIGDFRSLEK--ISREVKSITIIGGGF----LGSELACALGRKAR--ALGTEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVG M_mulatta_ENSMMUP00000006568 --PRSLSAIDRAGAEVKSRTTLFRKIGDFRSLEK--ISREVKSITIIGGGF----LGSELACALGRKAR--ALGTEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVG E_caballus_ENSECAP00000002768 --PRSLSAIDRAGAEVKSRTTLFRKIGDFRTLEK--ISREVKSITIIGGGF----LGSELACALGRKAR--ALGTEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVLPDAIVQSVG C_familiaris_ENSCAFP00000027660 --PRSLSAIDRAGAEVKSRTTLFRKIGDFRTLEK--ISREVKSITIIGGGF----LGSELACALGRKAR--ALGTEVIQLFPEKGNMGKILPEYLSNWTTEKVRREGVKVLPNAIVQSVG B_taurus_ENSBTAP00000008987 --PRSLSAIDRAGAEVKSRTTLFRKIEDFRTLEK--ISREVKSITIIGGGF----LGSELACALGRKAR--ASGTEVIQLFPEKGNMGKVLPEYLSNWTMEKVRREGVKVLPSAIVQSVG P_pygmaeus_ENSPPYP00000023188 --PRSLSAIDRAGAEVKSRTTLFRKIGDFRSLEK--ISREVKSITIIGGGF----LGSELACALGRKAR--ALGTEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVG R_norvegicus_ENSRNOP00000008503 --PRSLSAIDRAGAEVKSRTTLFRKIGDFRALEK--ISREVKSITVIGGGF----LGSELACALGRKSQ--ASGIEVIQLFPEKGNMGKILPEYLSNWTMEKVKREGVKVMPNAIVQSVG M_musculus_ENSMUSP00000041104 --PRSLSAIDRAGAEVKSRTTLFRKIGDFRALEK--ISREVKSITVIGGGF----LGSELACALGRKSQ--ASGIEVIQLFPEKGNMGKILPQYLSNWTMEKVKREGVKVMPNAIVQSVG M_domestica_ENSMODP00000027578 --PRNLSAIDRAGPEVKSRTTLFRKIGDYRSLEK--ISREVSSITVIGGGF----LGSELACALARKAR--TLGTEVIQLFPEKGNMGKILPEYLSNWTTEKVRKEGVKVMPNAVVQAVG P_troglodytes_ENSPTRP00000038338 --PRSLSAIDRAGAEVKSRTTLFRKIGDFRSLEK--ISREVKSITIIGGGF----LGSELACALGRK--------------PEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVG O_cuniculus_ENSOCUP00000002538 --PRNLSAIDRAGAEVKSRTTLFRKIGDFRALEK--ISREVKSITIIGGGF----LGSELACALGRKAR--ASGKEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVG A_carolinensis_ENSACAP00000008812 --PRSLPVIERAGKEVQEKLTLFRKIEDFRSLEK--ISREVQSITIIGGGF----LGSELACALGRKAQ--SRGLEVIQMFPENGNMGKVLPEYLSNWTTNKVRQEGVNVMPNSVVKSVS T_guttata_ENSTGUP00000005365 --PRNLPAIERAGKDVQKRLTLFRKIEDFRRLEK--ISREVKSITIIGGGF----LGSELACALGRRAR--TRGLEVIQLFPENGNMGKVLPEYLSNWTTEKVRREGVNVLPNAVVKSVS G_gallus_ENSGALP00000006366 --EEEEEGETRLPFEVKERVTLTSKIEDFKNLEK--ISRQVKSITIIGGGF----LGSELACALGRRAQ--TRNLEVIQLFPENGNMGKVLPEYLSNWTTEKVRREGVNVMPNAVVKSVS X_tropicalis_ENSXETP00000039440 --PRSLPAIERAGEEVTKRTTLFRRISDFRTLEA--ISSSVGSITIIGGGF----LGSELACALGRKGT--QTSLEVIQMFPESGNMGKVLPEYLSHWTTEKVQREGVNVLSDAVVKSVS D_rerio_ENSDARP00000075330 --PRNLQVIDRAGEEVIKRTTLFRKIEDFRSLEK--ISREVKSITIIGGGF----LGSELACALGRRSA--DPGLEVMQLFPEKGNMGKVLPEYLSNWTTEKVRKEGVNVITDAVVKNVT T_rubripes_ENSTRUP00000030183 --PRNLQVIDRAAEDVKSRTTLFRKIEDFKSLDK--VSRNIESITIIGGGF----LGSELACALGRRSN--ESGLEVVQMYPEKGNMGKVLPEYLSNWTTEKVKREGVKVITEALVKSVT T_nigroviridis_ENSTNIP00000014785 --PRNLQVIERAAEDVKSRATLFRKIEDFKSLDK--VSRNIESITIIGGGF----LGSELACALGRRSN--ESGLEVVQMYPEKGNMGKVLPEYLSNWTTDKVKREGVKVITEALVKSVT G_aculeatus_ENSGACP00000026857 --PRNLQVIERAGEEVMKRTTLFRKVEDFKSLDK--VSRNVKSITIIGGGF----LGSELACALGRRST--ESDLEVIQMYPEKGNMGKVLPEYLSNWTTEKVKKEGVKIISEALVKSVV O_latipes_ENSORLP00000012070 --PRNLQLIERAGEEVMKKTTLFRKIEDFKSLDK--VSRNVKSVTIIGGGF----LGSELACALGRRST--ESGLEVIQMFPEKGNMGKVLPEYLSNWTTEKVKKEGVKVLTEALVKSVS G_gorilla_ENSGGOP00000007470 --PRSLSAIDRAGAEVKSRTTLFRKXXXXXXXXX--XXXXXXXXXXXXXXX----XXXXXXXXXXXXXR--ALGTEVIQLFPEKGNMGKILPEYLSNWTMEKVRRXXXXXXXXXXXXXXX C_intestinalis_ENSCINP00000012225 --PKNLPVFRKASAEIQKKVSTYRTASDFTELNN--ITDGVKSITVIGGGF----MGSELACALGHKGQ--KVGFEVNQIFPENGNMGNVLPEYLTKWTTSKVKSEGVNVITDTVVNNVT A_gambiae_AGAP008044-PA --PKNLPIFESAPRAVRERVTLFKSVYDFEQLSS--QLQDGNRVAIVGGGF----LGSELACALSKSEQTRKKKVEVFQLFHEGGNMAKVLPEYLSSWTTERLREEGVKVWPKTQVKAVE A_aegypti_AAEL002016-PA --PKNLPVFESAPLAVKERVSMFKAVSDFEELTE--KLNEGSKIAIIGGGF----LGSELSCALARCSEIRNKNFEVYQLFHEEGNMGKILPEYLSQWTTERVREEGVKVWPKIQVKAAE T_guttata_ENSTGUP00000016816 --PRNLPAIERAGKDVQKRLTLFRKIEDFRRLEK--ISREVKSITIIGGGF----LGSELACALGRRAR--TRGLEVIQLFPENGNMGKVLPEYLSNWTTEKVRREGVNVLPNAVVKSVS D_melanogaster_FBpp0077504 --PKNLPMLRDAPPSVLEKVMVYRTPDDFDRLRK--LAAEKRSITIVGNGF----IGSELACSLAHYSR-ENNGGKVYQVFQENANMSKVLPNYLSRWTTAKMEAQGVCVIPNASIRSAV C_elegans_Y56A3A.32.1 --PKKEQVFEEASEEAKQKITYFHYPADFKRVERGLADKSVQKVTIIGNGL----LASELSYSIKRKYG---ENVEVHQVFEEKYPAEDILPEHIAQKSIEAIRKGGVDVRAEQKVEGVR O_anatinus_ENSOANP00000025948 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000013415 --PKTLSC----KGKEVENVFTIRTPEDANRVVR---LARGRNVVIVGAGF----LGMEVAAYLTEKAH------SVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELR P_troglodytes_ENSPTRP00000024275 --PKTLSC----KGKEVENVFTIRTPEDANRVVR---LARGRNVVVVGAGF----LGMEVAAYLTEKAH------SVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELR H_sapiens_ENSP00000382120 --PKTLSC----KGKEVENVFTIRTPEDANRVVR---LARGRNVVVVGAGF----LGMEVAAYLTEKAH------SVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELR T_guttata_ENSTGUP00000010972 --PKTLSC----KGKEMENVFNIRTPEDANRVVK---LATSKNVVIVGASF----LGMEVAAYLAERAH------SVSLVELEHVPFKKFFGERVGRAVMKMFENNRVKFYMQTEVSELR M_mulatta_ENSMMUP00000026974 --PRTLSC----KGKEMENVFTIRTPEDANRVVR---LARGRNVVIVGAGF----LGMEVAAYLTEKAH------SVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELR A_carolinensis_ENSACAP00000010903 --PKTLSC----KGKEVENVFTIRTVEDANRVVK---LATSKNAVVVGASF----LGMEVAAYLSDRAH------SVSVVELEEVPFKKFFGEKVGRALMKMFENNRVKFYMQTEVSELR T_nigroviridis_ENSTNIP00000021125 --ARPLGC----PGWDLQGVKLLQTHDDAKEIHA---SCQERNVVVIGASF----IGMEVASYLSNKAA------SVAVVGTSSYPFQKSLGQEIGKMCMQMFEEKNVKFYMNDGVTEIR C_intestinalis_ENSCINP00000015763 --PRTLPI----PGWDLKNVYVLRTPNDANAIAE---VAKGRKVVICGASF----IGMEVAASLVSKAE------SISVCEFFSVPFERVLGKEVGLFLQKMHESKGVKFHMNASMVELK B_taurus_ENSBTAP00000053272 --PKTLSC----KGKDVENVFTIRTPEDANRVVR---LARGRNAVVVGAGF----LGMEVAAYLTEKAH------SVSVVEVEETPFRRFLGERVGHTLMKMFENNRVKFYMQTEVSELR O_latipes_ENSORLP00000009976 --PKPMNY----KGNEVKNVFHLQTPEDANSIAR---LANNKNAVIVGTSF----VGMEVAAALTDKAH------SVSVIGIESLPFKKALGEKVGKVIMKLFEANRVKFYMLNEVSEMI G_gallus_ENSGALP00000012503 --PKALSC----KGKEVENVFNIRTPEDANRVVK---LATSKNVVIVGASF----LGMEVAAYLTERAH------SVSVVELEEVPFKKFFGERVGRAVMKMFESHRVKFYMQTEVSELR D_rerio_ENSDARP00000085557 --PKPLSY----KGKDVGNVFHLRTPEDANSIVT---LASSKNAVIIGTSF----IGMEVAAALTDKAH------SVSVIGIEAVPFRKALGEKVGKALMKLFEANRVKFYMLNEVWEMR M_musculus_ENSMUSP00000111349 --PKTLTC----KGKDVENVFTIRTPEDANRVLR---LARGRNAVVVGAGF----LGMEVAAYLTEKAH------SVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELR G_gallus_ENSGALP00000039047 --SSFLKV----PGADLQNVCHLQTPEDASKVLE---LASGKNLVIVGASF----IGMETAAFLSDKAA------AISVVEKQEFPFQKTLGPQVGGVVLKMLQSKGVKFYMKKELHELK O_latipes_ENSORLP00000010037 --ARPLSC----PGSDLKGVHLLQSYDDAKEIHS---SGTKQKAVVIGASF----IGVEVAAYLSDKAA------GVALVGPTQYPFENTLGPEIGRICMQMLEERNVKFYMNSKVTEIR R_norvegicus_ENSRNOP00000048427 --PKTLTC----KGKDIENVFTIRTPEDANRVLR---LARGRNAVVVGAGF----LGMEVAAYLTEKAH------SVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELR T_rubripes_ENSTRUP00000040612 --ARPLSC----PGWDLKGVKLLQTHDDANEIHS---SCQGQNAVIIGASF----IGMEVASYLSNKAA------SVTVVGTSSYPFQKSLGSEIGKMCMEMFEEQNVKFYMNDGVTEIR G_aculeatus_ENSGACP00000012379 --PKPMVY----NGKDVRNVFHLRTPEDANSIAR---LANNKNAVIVGTSY----VGMEVAAALTDKAH------SVSIIGIESVPFKKALGEKVGKAVMKLFEVNRVKFYMLNEVSEMI T_nigroviridis_ENSTNIP00000018986 --PRAMSY----KGKDVRNVFHLRTPEDANNIAK---LSSNKNAVIVGTSF----VGMEVAAALTDKAH------SVSVIGIESVPFKQALGEKVGKAVMKLFEANRVKFYMMNEVSEMV G_aculeatus_ENSGACP00000011210 --ARPLDC----PGWDLHGVKLLQTHEDANEIHH---SALGQKAVVIGASFIGTTIGMEVASYLSNTAA------SVAVVGPSRYPYERSLGPQIGRMIMQMLEEKNVKFYMTDFVDEIK T_guttata_ENSTGUP00000005877 --SGSLKV----PGADLQNICTLQTPEESSKILE---LATGKNLVIVGASF----IGTRLASRLPAAAR---DTNGISLQPGAAAELPACLGFGWVQLPFQMLQNKGVKFHMKTEICELR D_melanogaster_FBpp0080714 --AVTPNI----PGVHLKNVKVIRNIGDARSIFK--MVDKSTQVVCLGSSF----MAVEATANLVSRAR------SVTLVARQNVPFKSTLGELIGQRILKLLEENKVDLRMSSGIIRIL T_rubripes_ENSTRUP00000040932 KSPKPMSY----KGKDVRNVFHLCTPEDANSIAQ---LSNNKNAVIVGTSF----VGMEVAAALTDKAH------SVSVIGIESVPFKQALGEKVGKALMKLFEANRVKFYMMSEVSEMV X_tropicalis_ENSXETP00000057179 --PKTLKC----KGKELDNVFTIRTPEDANKVVR---LASSKNAVIVGASF----LGMEVAAYLCEKAH------SVSVVELENIPFKKFLGEKVGLAIMKMFENNRVKFYMQTEVSELR A_carolinensis_ENSACAP00000014484 --PRLLGC----SGCDLE-VCTLLTPEDG-RILR---LATGRKVAIIGGSF----IGMELASSLAGKAS------AIQVVERGHAPYHAVLGGQVGQVAMKMLQSQGVEFHLEAEVAELK O_latipes_ENSORLP00000003241 --AKALDV----PGTKLRNIMMLETPEDARQIHA---ACMGSNVVLVGTSF----VGMEVASYLLDKAS------SITVIGSSELPYQNTLGREVGRITMMMLSEYNIKFYMNDIVTEIK G_aculeatus_ENSGACP00000027082 --AKGLDV----PGTKLDNVRMLETPEDARHIHT---ACLGSDVVLVGTSF----VGMEVASYLVDKAS------SVTVIGSSELPYQNTLGREIGKVSMMMLTEQNVKFYMNENVTEIK T_nigroviridis_ENSTNIP00000019217 --AKSLNV----PGMNLENVKMLETPEDARQIHD---ACMGSRVVLVGTSF----VGMEIASYLIDKAS------SIAVIGSSEMPYQNTLGPEIGRVTMKMLAEKNVEFHMNDSVVEVR C_elegans_F20D6.11 --VRKLQV----PGSDLKNICYLRKVEEANIISN---LHPGKHVVCVGSSF----IGMEVASALAEKAA------SVTVISNTPEPL-PVFGSDIGKGIRLKFEEKGVKFELAANVVALR T_rubripes_ENSTRUP00000030429 --AKGLNV----PGINLDNVKMLETPEDARQIHE---ACMGSKVVLVGTSF----VGMEIASYLIDKAS------SITVIGSSELPYQSTLGPEIGRVTMMMLTEKNVRFYMNDSVLEVR D_melanogaster_FBpp0070319 --AFRPPI----PGVNLENVRTVRELADTKAILA--SITPESRVVCLGSSF----IALEAAAGLVSKVQ------SVTVVGRENVPLKAAFGAEIGQRVLQLFEDNKVVMRMESGIAEIV A_aegypti_AAEL011158-PA --ARKAPI----EGADMPNVCVLRSNEHSKHVNG--QLSPDKHVVVLGVSF----IGLEAAAYCVNKVA------KVTVIGRGAVPLVESFGEQVGSKVMQWFKEKGVHFIMNSGIKRCI 730 740 750 760 770 780 790 800 810 820 830 840 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000287295 VSS-GKL-LIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVN--AELQA---------RSNIWVAGDAACFYDI--KLGRRR--VEHHDHAVVSGRLAGENMTGAA--- M_mulatta_ENSMMUP00000006568 VSS-GKL-LIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVN--AELQA---------RSNIWVAGDAACFYDI--KLGRRR--VEHHDHAVVSGRLAGENMTGAA--- E_caballus_ENSECAP00000002768 VSG-GKL-LIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVN--AELQA---------RSNIWVAGDAACFYDI--KLGRRR--VEHHDHAVVSGRLAGENMTGAA--- C_familiaris_ENSCAFP00000027660 VSG-GRL-LIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVN--AELQA---------RSNIWVAGDAACFYDI--KLGRRR--VEHHDHAVVSGRLAGENMTGAA--- B_taurus_ENSBTAP00000008987 VSA-GRL-LIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVN--AELQA---------RSNIWVAGDAACFYDI--KLGRRR--VEHHDHAVVSGRLAGENMTGAA--- P_pygmaeus_ENSPPYP00000023188 VSS-GKL-LIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVN--AELQA---------RSNIWVAGDAACFYDI--KLGRRR--VEHHDHAVVSGRLAGENMTGAA--- R_norvegicus_ENSRNOP00000008503 VSG-GKL-LIKLKDGRKVETDHIVTAVGLEPNVELAKTGGLEIDSDFGGFRVN--AELQA---------RSNIWVAGDAACFYDI--KLGRRR--VEHHDHAVVSGRLAGENMTGAA--- M_musculus_ENSMUSP00000041104 VSG-GRL-LIKLKDGRKVETDHIVTAVGLEPNVELAKTGGLEIDSDFGGFRVN--AELQA---------RSNIWVAGDAACFYDI--KLGRRR--VEHHDHAVVSGRLAGENMTGAA--- M_domestica_ENSMODP00000027578 VKS-GKL-LIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEVDSDFGGFRVN--AELQA---------RSNIWVAGDAACFYDI--KLGRRR--VEHHDHAVVSGRLAGENMTGAA--- P_troglodytes_ENSPTRP00000038338 VSS-GKL-LIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVN--AELQA---------RSNIWV--------------------------------------------- O_cuniculus_ENSOCUP00000002538 VSG-GKL-LIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVN--AELQA---------RSNIWVAGDAACFYDI--KLGRRR--VEHHDHAVVSGRLAGENMTGAA--- A_carolinensis_ENSACAP00000008812 VAG-NRL-LIKLKDGRKVETDHIVAAVGLEPNVELAKSAGLEVDSDFGGFRVN--AELQA---------RSNIWVAGDAACFYDI--KLGRRR--VEHHDHAVVSGRLAGENMTGAA--- T_guttata_ENSTGUP00000005365 VSG-NRL-VIKLKDGRKVETDHIVAAVGLEPNVELAKSAGLEVDSDFGGFRVN--AELQA---------RSNIWVAGDAACFYDI--KLGRRR--VEHHDHAVVSGRLAGENMTGAA--- G_gallus_ENSGALP00000006366 VSG-NRL-VIKLKDGRKVETDHIVAAVGLEPNVELAKSAGLEVDSDFGGFRVN--AELQA---------RSNIWVAGDAACFYDI--KLGRRR--VEHHDHAVVSGRLAGENMTGAA--- X_tropicalis_ENSXETP00000039440 YQN-GKL-HIQLKDGRQVQTDHIVAAVGLEPNTELAKSAGLELDGDFGGYRVN--AELQA---------RNNVWVAGDAACFYDI--KLGRRR--VEHHDHAVVSGRLAGENMTGAA--- D_rerio_ENSDARP00000075330 YKN-DKL-EIKLKDGRLVKTDHIVAAVGLEPSVELAKSAGLEVDSDFGGYRVN--AELQA---------RSNIWVAGDAACFYDI--KLGRRR--VEHHDHAVVSGRLAGENMTGAN--- T_rubripes_ENSTRUP00000030183 FKD-DKL-EIQLKDGRKVRTDHIVAAVGLEPNIDLAKSAGLEVDPDFGGYRVN--AELQA---------RSNIWVAGDAACFYDI--RLGRRR--VEHHDHAVVSGRLAGENMTGAN--- T_nigroviridis_ENSTNIP00000014785 FKD-EKL-EIQLKDGRKVRTDHIVAAVGLEPNVDLAKSAGLEVDPDFGGYRVN--AELQA---------RSNIWVAGDAACFYDI--RLGRRR--VEHHDHAVVSGRLAGENMTGAN--- G_aculeatus_ENSGACP00000026857 SKD-DKL-EIQLKDGRLVKTDHIVAAVGLEPNVDLAKSAGLEVDSDFGGFRVN--AELQA---------RSNIWVAGDAACFYDI--RLGRRR--VEHHDHAVVSGRLAGENMTGAN--- O_latipes_ENSORLP00000012070 CKD-DQL-EIKLKDGRVVTTDHIVAAVGLEPNVDLAKSAGLEVDSDFGGYRVN--AELQA---------RSNIWVAGDAACFYDI--RLGRRR--VEHHDHAVVSGRLAGENMTGAS--- G_gorilla_ENSGGOP00000007470 XXX-XXX-XXXXXXXXXVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVN--AELQA---------RSNIWVXXXXXXXXXX--XXXXXX--XXXXXXXXXXXXXXXXXXXXXX--- C_intestinalis_ENSCINP00000012225 MQD-GRL-KLQLRTGQEILTDHVVVAVGLGIDTSLAESGGLETDERFGGYRVN--AELQA---------RSNIWVAGDASCFFDA--KLGRRR--VEHHDHAVVSGRLAGENMAGGQ--- A_gambiae_AGAP008044-PA MQG-SKL-KLTLMDDSVLLVDRVIVAVGSEPNTDLAKTSGLEVDGKNGGFLVD--AELRA---------RSNVFVAGDAACFYDT--KFGRRR--VEHHDHAIVSGRLAGENMVGLN--- A_aegypti_AAEL002016-PA VQD-KKL-KLTLTDDSCLVVDHAIVAVGSEPNTDLAKTSNLETDPSMGGFVVD--AELRA---------RSHLYVAGDAACFFDP--KLGRRR--VEHHDHAVVSGRLAGENMVGLN--- T_guttata_ENSTGUP00000016816 VSG-NRL-VIKLKDGRKVETDHIVAAVGLEPNVELAKSAGLEVDSDFGGFRVN--AELQA---------RSNIWV--------------------------------------------- D_melanogaster_FBpp0077504 RDE-TNL-KLELNNGMTLMSDVVVVCVGCTPNTDLAGPSRLEVDRSLGGFVVN--AELEA---------RRNLYVAGDASCFFDP--LLGRRR--VEHHDHSVVSGRLAGENMTGAK--- C_elegans_Y56A3A.32.1 KCC-KNV-VLKLSDGSELRTDLVVVATGEEPNSEIIEASGLKIDEKLGGVRAD--KCLKV---------GENVWAAGAIATFEDG--VLGARR--VSSWENAQISGRLAGENMATAAADG O_anatinus_ENSOANP00000025948 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000013415 GQE-GKLKEVVLKSSKVVRADVCVVGIGAVPATGFLRQSGIGLDSR-GFIPVN--KMMQT--------NVPGVFAAGDAVTFPLA--WRNNRKVNIPHWQMAHAQGRVAAQNMLAQE--- P_troglodytes_ENSPTRP00000024275 GQE-GKLKEVVLKSSKVVRADVCVVGIGAVPATGFLRQSGIGLDSR-GFIPVN--KMMQT--------NVPGVFAAGDAVTFPLA--WRNNRKVNIPHWQMAHAQGRVAAQNMLAQE--- H_sapiens_ENSP00000382120 GQE-GKLKEVVLKSSKVVRADVCVVGIGAVPATGFLRQSGIGLDSR-GFIPVN--KMMQT--------NVPGVFAAGDAVTFPLA--WRNNRKVNIPHWQMAHAQGRVAAQNMLAQE--- T_guttata_ENSTGUP00000010972 EQE-GKLKEVVLKSGKVLRADVCVVGIGAVPATGFLKQSGINIDSK-GFIVVN--KMMQT--------NIPGVFAAGDAVTFPLA--LRNNKKVNVPHWQMAHMHGRIAALNMLAHG--- M_mulatta_ENSMMUP00000026974 GQE-GKLKEVVLKSSKVVRADVCVVGIGAVAATGFLRQSGIGLDSR-GFIPVN--KMMQT--------NVPGVFAAGDAVTFPLA--WRNNRKVNIPHWQMAHAQGRVAAQNMLAQE--- A_carolinensis_ENSACAP00000010903 EQE-GKLKEVVLKSGKVLRADVCVIGIGATPATGFLKQSGVHVDSK-GFIAVN--KMMQT--------SIPGVFAAGDAVAFPLS--LRNNKKVNIPHWQMAHMHGRIAALNMLAHG--- T_nigroviridis_ENSTNIP00000021125 GNN-GKVKEVVLKSGTVLEADVVVAGIGVIPNTDFLSGSKLEMNSK-NTLVVD--KFMRT--------NVPDIFSAGDVTSFPLT--IRGDEVVNIGHWQMSQAQGRVAALNMLKKP--- C_intestinalis_ENSCINP00000015763 GEN-GAVAKAILKDGSELEADLVIAGVGMIPATEFLKDTGIQISSH-GFVGVD--RHMRALKSSGDGEIFENIYAAGDIAINMLVHPQWDWQPSNIQHWQMAHYHGRVAGTNMVVPNDEL B_taurus_ENSBTAP00000053272 AQE-GKLKEVVLKSSKVVRADVCVVGIGAVPATGFLRQSGISLDSR-GFIPVN--KMMQT--------NIPGVFAAGDAVTFPLA--WRNNRKVNIPHWQMAHAQGRVAAQNMLAQE--- O_latipes_ENSORLP00000009976 GHH-GQLKEVVLKSGKVLRADVCVIGAGSVPASGFLKQSGIHLDSK-GFITVN--KMMQT--------NVEGVFAGGDVVTFPFP--QRNNKKVNIPHWQMAHVHGRVAALSMMGRA--- G_gallus_ENSGALP00000012503 EQE-SKLKEVVLKSGKVLRADVCVVGIGAVPATGFLKQSGINIDSK-GFIVVN--KMMQT--------NIPGVFAAGDAVTFPLA--LRNNKKVNVPHWQMAHMHGRIAALNMLAHG--- D_rerio_ENSDARP00000085557 GHN-GQLKEVVLKSGKVLRADVCVIGIGSSPATAFLKQSGVHIDSK-GFIPVN--KTMQT--------NIDGVFAGGDVVTFPLA--LRSNKKVNIPHWQMAHVHGRLAALGIMGKA--- M_musculus_ENSMUSP00000111349 AQE-GKLQEVVLKSSKVLRADVCVLGIGAVPATGFLRQSGIGLDSR-GFIPVN--KMMQT--------NVPGVFAAGDAVTFPLA--WRNNRKVNIPHWQMAHAQGRVAAQNMLAQE--- G_gallus_ENSGALP00000039047 GKD-GKVAEAILASGEKLPADVVVVGIGVTPNSAFLKGTSIAKDNS-GAILVD--LRMQT--------NIPNVFAAGDVVSFPVA--LLNGDHSSIHHQQVAEAHGSIAAFNMLKKQ--- O_latipes_ENSORLP00000010037 GEN-GKVKEVVLNNGTVLEADVVIAGIGAIPNSGFLAGTEIAVDSK-KAVIVD--KFMRT--------NTPDIFAAGDVTSFPLT--IRGGEQVSIGHWQMSHAHGKIAGLNMMKKP--- R_norvegicus_ENSRNOP00000048427 AQE-GKLQEVVLKSSKVLRADVCVVGIGAVPATGFLRQSGIGLDSR-GFIPVN--KMMQT--------NIPGVFAAGDAVTFPLA--WRNNRKVNIPHWQMAHAQGRVAAQNMLAQE--- T_rubripes_ENSTRUP00000040612 GNS-GKVKEVVLKS-TILEADVVVAGIGVIPNTDFLIGSKLEVDSR-KTLVVD--KFMKT--------NVPDIFSAGDVTSFPLS--ICGDKMVNIGHWQMSQAQGRVAALNMLKKP--- G_aculeatus_ENSGACP00000012379 GQH-GQLKEVVLKSGKVLRADVCVIGAGSIPATGFLKQSGIHMDSR-GFITVN--KMMQT--------NADGVFAGGDVVVFPFP--PRHNKKVNIPHWQMAHVHGRVAALGMMGRP--- T_nigroviridis_ENSTNIP00000018986 GHH-GQLKEVVLNSGKVLRADVCVIGAGSVPATGFLKQSGIHMDSK-GFITVN--KTMQT--------NVEGVFAGGDAVIFPFP--PRNNKKVNIPHWQMAHVHGRVAALGMLGRA--- G_aculeatus_ENSGACP00000011210 GEN-GKVKGVLLKSGIVLEADVVIAGIGVIPNSDFLTGSQLEVDSR-KAVIVD--KFMRT--------NIPDIFSAGDVTSFPLT--IRGDQRVNVGHWQMSQAQGRVAALNMLKKP--- T_guttata_ENSTGUP00000005877 GKD-GKVTEAVLANGEKLPADVVVVGIGSAPNSAFLKGTSIARDDK-GAILVN--LHMQT--------NIPNVFAAGDVVTFPVA--LLDGDSSSIHHQQVAEAHGHCAALNMLRRG--- D_melanogaster_FBpp0080714 GNSRGEVVAVKLLDNSRIPCNLLILGTGCQCNTDFLQRSGININPN-GSVDVN--DFLQT--------KVRNVYVGGDIANAYIL--GGFPDRVNISHYGLAQYHGRIAALNMSGHI--- T_rubripes_ENSTRUP00000040932 GHH-GQLKEVVLNSGKVLRADVCVIRAGSVPATGFLKQSGINMDSK-GFITVN--KMMQT--------SADGVFAGGDAVTFPFP--PRNNKKVNIPHWQMAHVHGRMAALSMMDRA--- X_tropicalis_ENSXETP00000057179 EQE-GKLKEVVLKSGKVLRADVCVIGIGASPTTGFLKQSGVALDSR-GYILVN--KMMQT--------NIPGVFAAGDVVTFPLA--FRNNKKVNVPHWQMAHMQGRIAALNMLAQG--- A_carolinensis_ENSACAP00000014484 GQE-GKVTHVILGSGHKIPADVVVVGIG-------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000003241 GVN-GKVKEVVLKSGKVIPTDVLIVGIGSIPNSAFLQGTKIQMNPK-KLVIVD--KYMRT--------NVPDVFCAGDLATFPLA--MAKNQLVNIGHWQMAQAQGRVAALNMLGKE--- G_aculeatus_ENSGACP00000027082 GVD-GKVKEVVLKSGKVIPADVLIVGIGIKPNSEFLRGSKILTDSK-NFVPVD--RYMRT--------NVPGVFCGGDLATFPLA--MAKNRPVNIGHWQMAQAHGRIAALNMLDKQ--- T_nigroviridis_ENSTNIP00000019217 GQE-GKVKEVVLKSARVLLADVFIVGIGVKPNSEFLRGSGIQLDSR-NFVMVD--KYMRT--------NMPGVFCGGDVATFPLT--MAKNRPVHIGHWQMAQAHGRIAALNMLEKP--- C_elegans_F20D6.11 GNDQGEVSKVILENGKELDVDLLVCGIGVTPATKFLEGSGIKLDNR-GFIEVD--EKFRT--------NISYIFAMGDVVTAPLP--LWDIDSINIQHFQTAQAHGQHLGYTIVGKP--- T_rubripes_ENSTRUP00000030429 GQD-GKVKEVVLKSAKVLPADVFIVGIGVKPNSEFLRGSRIQLDSR-NFVVVDKPKYMRT--------NIPGVFCGGDVATFPLT--MAKNQPVNIGHWQMAQAHGRTAALNMLDKP--- D_melanogaster_FBpp0070319 GNEDGKVSEVVLVDDTRLPCDLLILGTGSKLNTQFLAKSGVKVNRN-GSVDVT--DFLES--------NVPDVYVGGDIANAHIH--GLAHDRVNIGHYQLAQYHGRVAAINMCGGV--- A_aegypti_AAEL011158-PA GDDDRKLTSVELNDGTILKADLCIMGIGSTLFTTFLEGSGVKVNKG-GSVDTN--RFLET--------NVPGIYAGGDIAHAPVF--CNNNEPATIGHYPLAQYHGKVAALNMVGKA--- 850 860 870 880 890 900 910 920 930 940 950 960 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000287295 ----KPYWHQSMFWSD--LGPDVGYEAIG------LVDSSLPTVGVFAKATAQDNPKSATEQ-----SGTGIRSE-SETESEASEIT--------IPPSTPAVPQA---P-VQGEDYGKG M_mulatta_ENSMMUP00000006568 ----KPYWHQSMFWSD--LGPDVGYEAIG------LVDSSLPTVGVFAKATAQDNPRSATEQ-----SGTGIRSE-SETESEASEIA--------IPPSTPAVPQA---P-VQGEDYGKG E_caballus_ENSECAP00000002768 ----KPYWHQSMFWSD--LGPDVGYEAIG------LVDSSLPTVGVFAKATAQDNPKSATEQ-----SGTGIRSE-SETESEASEIA--------IPSGNPAVPQA---P-TQGEDYGKG C_familiaris_ENSCAFP00000027660 ----KPYWHQSMFWSD--LGPDVGYEAIG------LVDSSLPTVGVFAKATAQDNPKSATEQ-----SGTGIRSE-SETESEASEIA--------VPPSNPAVPQT---P-AQGEDYGKG B_taurus_ENSBTAP00000008987 ----KPYWHQSMFWSD--LGPDVGYEAIG------LVDSSLPTVGVFAKATAQDNPKSATEQ-----SGTGIRSE-SETESEASDIP--------VPPSNPAVPQV---P-TQGEDYGKG P_pygmaeus_ENSPPYP00000023188 ----KPYWHQSMFWSD--LGPDVGYEAIG------LVDSSLPTVGVFAKATAQDNPKSATEQ-----SGTGIRSE-SETESEASEIT--------IPPSTPAVPQA---P-VQGEDYGKG R_norvegicus_ENSRNOP00000008503 ----KPYWHQSMFWSD--LGPDVGYEAIG------LVDSSLPTVGVFAKATAQDNPKSATEQ-----SGTGIRSE-SETESEASEIT--------IPPSDPAVPQV---P-VEGEDYGKG M_musculus_ENSMUSP00000041104 ----KPYWHQSMFWSD--LGPDVGYEAIG------LVDSSLPTVGVFAKATAQDNPKSATEQ-----SGTGIRSE-SETESEASEIT--------IPPSAPAVPQV---P-VEGEDYGKG M_domestica_ENSMODP00000027578 ----KPYWHQSMFWSD--LGPDVGYEAIG------LVDGSLPTVGVFAKATAKDTPKSATEQ-----SGTGIRSE-SETESEASDID--------IPPSDAKTPQS---L-IKGEDFGKG P_troglodytes_ENSPTRP00000038338 --------------SD--LGPDVGYEAIG------LVDSSLPTVGVFAKATAQDNPRSATEQ-----SGTGIRSE-SETESEASEIT--------IPPSTPAVPQA---P-IQGEDYGKG O_cuniculus_ENSOCUP00000002538 ----KPYWHQSMFWSD--LGPDVGYEAIG------LVDSSLPTVGVFAKATAQDSPKSATEQ-----SGTGIRXX-XXXXXXXXXXX--------XXXXXXXXXXX---X-XXXXXXXXX A_carolinensis_ENSACAP00000008812 ----KPYWHQSMFWSD--LGPDVGYEAIG------LVDSGLPTVGVFAKATARDTPKSATEE-----SGTGIRSE-SETEMEASELK--------VSAASPSSLQA---P-QQGEDYGKG T_guttata_ENSTGUP00000005365 ----KPYWHQSMFWSD--LGPNVGYEAIG------LVDSSLPTVGVFAKATAKDTPKSATEQ-----SGTGIRSE-SETEAEASEVQ--------ISQSSSPMPQV---P-KQGEDYGKG G_gallus_ENSGALP00000006366 ----KPYWHQSMFWSD--LGPDVGYEAIG------LVDSTLPTVGVFAKATAKDTPKSATEQ-----SGTGIRSE-SETEAEASEVP--------ISPSSSPTPQV---P-KEGEDYGKG X_tropicalis_ENSXETP00000039440 ----KPYWHQSMFWSD--LGPEVGYEAIG------IVDSALPTVGVFAKATEKDTPKRAAEE-----SGTGIRSE-SEVAETGPVEE--------VKPPASSSEFA---PSQQGDNYGKG D_rerio_ENSDARP00000075330 ----KPYWHQSMFWSD--LGPDVGYEAIG------IVDSSLPTVGVFAKATAKDTPKAATEQ-----SGTGIRSE-SETEAVAGVLE--------VGTVTPAPP-V-----QQKEDYGKG T_rubripes_ENSTRUP00000030183 ----KPYWHQSMFWSD--LGPDVGYEAIG------IVDSSLPTVGVFAKATEKDTPKAATEK-----SGTGIRSE-SETEETAASTE--------PSSSPAPAP-A---PEKQKDDYGKG T_nigroviridis_ENSTNIP00000014785 ----KPYWHQSMFWSD--LGPDVGYEAIG------IVDSSLPTVGVFAKATEKDTPKAATEK-----SGTGIRSE-SETEETATSTE--------SSSSPAPAP------EKPKDDYGKG G_aculeatus_ENSGACP00000026857 ----KPYWHQSMFWSD--LGPDVGYEAIG------IVDSSLPTVGVFAKATAKDTPKAATEE-----SGTGIRSE-SETEHTASSPV--------ASSA--PSP-T---GVQHKDEYGKG O_latipes_ENSORLP00000012070 ----KPYWHQSMFWSD--LGPDVGYEAIG------IVDSSLPTVGVFAKATAKDTPKAATEM-----SGTGIRSE-SETEDTAVSPV--------ASDT--PSP-A---A-ENKDDFGKG G_gorilla_ENSGGOP00000007470 ----XXXXXXXXXXSD--LGPDVGYEAIG------LVDSSLPTVGVFAKATAQDNPKSATEQ-----SGTGIRSE-SETESEASEIT--------IPPSTPAVPQA---P-VQGEDYGKG C_intestinalis_ENSCINP00000012225 ----KSYYHQSMFWSD--LGPDVGYEAIG------IIDSALPTVGVFAKATEKDTPKAA--------EGAGLRDDGAENPAENTEKQ--------------PTTTT---TTASSEEFGKG A_gambiae_AGAP008044-PA ----KPYTHQSMFWSD--LGPRISYEAIG------LIDSSLPTVAVFAKRTAEEMSRASAAA-----AAAVTAGS-TDSEKLQAANANVNVDVKNVPAAGEPAKEQSKEQQEPEDSFDKG A_aegypti_AAEL002016-PA ----KPYTHQSMFWSD--LGPKIGYEAIG------IIDSALPTVAVFAKSTPPQTIPDTSEKLQAANASVTPANS-NGGESSSSVLSNPNV----VKAEQKPAPPA----EEDQEDFNKG T_guttata_ENSTGUP00000016816 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0077504 ----KPYQHQSMFWSD--LGPEIGYEGIG------LVDSSLPTVGVFALPSESATRVDQLSE-----SSDSDVPETSTSSSQSSKSD--------AGASQDGVT-C---DPDEAGNYGKG C_elegans_Y56A3A.32.1 KSEGKAFWYQPSFFTK--FAPHLHINAIG------KCDSSLETVSVHAEP-DKDTP------------------------------------------------------------LEKA O_anatinus_ENSOANP00000025948 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000013415 ----AEMSTVPYLWTA-MFGKSLRYAGYGEGFDDVIIQGDLEEL--------------------------------------------------------------------------KF P_troglodytes_ENSPTRP00000024275 ----AEMTTVPYLWTA-MFGKSLRYAGYGEGFDDVIIQGDLEEL--------------------------------------------------------------------------KF H_sapiens_ENSP00000382120 ----AEMSTVPYLWTA-MFGKSLRYAGYGEGFDDVIIQGDLEEL--------------------------------------------------------------------------KF T_guttata_ENSTGUP00000010972 ----TEISTVPYLWTA-MFGKSIRYAGHGEGFDDVVIQGDLDEL--------------------------------------------------------------------------KF M_mulatta_ENSMMUP00000026974 ----AEMNTVPYLWTA-MFGKSLRYAGYGEGFDDVIIQGDLEEL--------------------------------------------------------------------------KF A_carolinensis_ENSACAP00000010903 ----TEISTVPYLWTA-MFGKSIRYAGHGEGFDDVIIRGDLDEL--------------------------------------------------------------------------KF T_nigroviridis_ENSTNIP00000021125 ----TKFESVPFFWTV-LLGKSIRYTGYGEGYTEIIYKGNVEER--------------------------------------------------------------------------KF C_intestinalis_ENSCINP00000015763 ----QSVESVPFFWTQ-QYGKSLRYTGYGVGYDDIVIKGEVSEG--------------------------------------------------------------------------KF B_taurus_ENSBTAP00000053272 ----AEISTVPFLWTA-MFGKSLRYAGYGEGFDDVIIQGDLDEL--------------------------------------------------------------------------KF O_latipes_ENSORLP00000009976 ----SEAKTVPYFWSA-MFGKTIRYAGYGDGFDDVIIQGDLDEL--------------------------------------------------------------------------RF G_gallus_ENSGALP00000012503 ----TEISTVPYLWTA-MFGKSIRYAGHGEGFDDVVIQGDLDEL--------------------------------------------------------------------------KF D_rerio_ENSDARP00000085557 ----SDIKTVPYFWTA-MFGKSIRYAGYGDGFDDVVIQGDLDEL--------------------------------------------------------------------------KF M_musculus_ENSMUSP00000111349 ----AEINTVPYLWTA-MFGKSLRYAGYGEGFDDVIIQGDLEEL--------------------------------------------------------------------------KF G_gallus_ENSGALP00000039047 ----KELHTVPFFWTT-MLGRSIHYAGCGKGYTDTVLKGSLEEQ--------------------------------------------------------------------------KF O_latipes_ENSORLP00000010037 ----TPIESVPFFWTT-FLGKGIRYTGYGEGYTEIIFKGKVEER--------------------------------------------------------------------------KF R_norvegicus_ENSRNOP00000048427 ----AEINTVPYLWTA-MFGKSLRYAGYGEGFDDVIIQGDLEEL--------------------------------------------------------------------------KF T_rubripes_ENSTRUP00000040612 ----TEFQSVPFFWTV-LLGKSIRYTGYGEGYTEIIYKGSIQER--------------------------------------------------------------------------KF G_aculeatus_ENSGACP00000012379 ----ADLKTVPYFWSA-MFGKTIRYAGYGDGFDDVIIQGDLDEL--------------------------------------------------------------------------RF T_nigroviridis_ENSTNIP00000018986 ----ADIKTVPFFWSA-MFGKTLRYAGYGDGFDDVIIQGDLDEL--------------------------------------------------------------------------KF G_aculeatus_ENSGACP00000011210 ----TKCESVPFFWTV-LLGKSIRYTGYGEGYTEILFKGKVEER--------------------------------------------------------------------------KF T_guttata_ENSTGUP00000005877 ----KELHTVPYFWTM-LLGKSIRYAGCGKGYTDTVVKGSLEQQ--------------------------------------------------------------------------KF D_melanogaster_FBpp0080714 ----AKLEAIPFFYTV-IFGRAFRSAGYGP-FKDVVIDGSLEDL--------------------------------------------------------------------------QF T_rubripes_ENSTRUP00000040932 ----ADIKTVPFFWSA-MFGKTLRYAGYGDGFDDVIIQGDLDEL--------------------------------------------------------------------------RF X_tropicalis_ENSXETP00000057179 ----TEINTVPYLWTA-MFGKSIRYAGHGDGFDDVIIQGDIDEL--------------------------------------------------------------------------KF A_carolinensis_ENSACAP00000014484 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003241 ----TELTSVPFYWTV-LLGKTIRYAGYGEGYTELVMKGNIQEH--------------------------------------------------------------------------KF G_aculeatus_ENSGACP00000027082 ----IELSSVPFYWTV-LLGKTIRYTGFGEGYTDIVMKGALEDR--------------------------------------------------------------------------KF T_nigroviridis_ENSTNIP00000019217 ----TELSSVPFYWTV-LLGKTIRYAGYGEGYTEIVVKGRLEDK--------------------------------------------------------------------------KF C_elegans_F20D6.11 ----QPGPIVPYFWTLFFFAFGLKFSGCNQGSTKEYTNGDPETG--------------------------------------------------------------------------TF T_rubripes_ENSTRUP00000030429 ----TELSSVPFYWTV-LLGKTIRYAGYGEGYTEIVVKGKLEDK--------------------------------------------------------------------------KF D_melanogaster_FBpp0070319 ----KKLEAVPFFFTL-IFGKGIRYAGHGS-YKDVIIDGSMEDF--------------------------------------------------------------------------KF A_aegypti_AAEL011158-PA ----TELKSVPYFWTM-LFGKGFRYAGYGRPH-ETIIEGDLEQL--------------------------------------------------------------------------KF 970 980 990 1000 1010 1020 1030 =========+=========+=========+=========+=========+=========+=========+= H_sapiens_ENSP00000287295 VIFYL--RDKVVVGIVLWNIFN-RMPIARKIIKDGEQHEDLNEVAKLFNIHED------------------ M_mulatta_ENSMMUP00000006568 VIFYL--RDKVVVGIVLWNIFN-RMPIARKIIKDGEQHEDLNEVAKLFNIHED------------------ E_caballus_ENSECAP00000002768 VIFYL--RDKVVVGIVLWNIFN-RMPIARKIIKDGEQHEDLNEVAKLFNIHED------------------ C_familiaris_ENSCAFP00000027660 VIFYL--RDKVVVGIVLWNIFN-RMPIARKIIKDGEQHEDLNEVAKLFNIHED------------------ B_taurus_ENSBTAP00000008987 VIFYL--RDKVVVGIVLWNIFN-RMPIARKIIKDGEQHEDLNEVAKLFNIHED------------------ P_pygmaeus_ENSPPYP00000023188 VIFYL--RDKVVVGIVLWNIFN-RMPIARKIIKDGEQHEDLNEVAKLFNIHED------------------ R_norvegicus_ENSRNOP00000008503 VIFYL--RDKVVVGIVLWNVFN-RMPIARKIIKDGEQHEDLNEVAKLFNIHED------------------ M_musculus_ENSMUSP00000041104 VIFYL--RDKVVVGIVLWNVFN-RMPIARKIIKDGEQHEDLNEVAKLFNIHED------------------ M_domestica_ENSMODP00000027578 VIFYL--RDKVVVGILLWNIFN-RMPIARKIIKDGEEHEDLNEVAKLFNIHED------------------ P_troglodytes_ENSPTRP00000038338 VIFYL--RDKVVVGIVLWNIFN-RMPIARK----------------------------------------- O_cuniculus_ENSOCUP00000002538 XXXXX--XXXXXXXXXXXXXXX-XXXXXXXIIKDGEQHEDLNEVAKLFNIHED------------------ A_carolinensis_ENSACAP00000008812 VIFYL--RDKVVVGIVLWNIFN-RMPIARKIIKDGEGHTDLNEVAKLFNIHED------------------ T_guttata_ENSTGUP00000005365 VIFYL--RDKVVVGIVLWNIFN-RMPIARKIIKDGEEHEDLNEVAKLFNIHEE------------------ G_gallus_ENSGALP00000006366 VIFYL--RDKVVVGIVLWNIFN-RMPIARKIIKDGEEHADLNEVAKLFNIHED------------------ X_tropicalis_ENSXETP00000039440 VVFYL--RDNVVVGMVLWNIFN-RMPIARKIIKDGEQHSDLNEVAKLFNIHEE------------------ D_rerio_ENSDARP00000075330 IIFYL--RDKVVVGIVLWNVFN-RMPIARKIIKDGEAHTDLNEVAKLFNIHED------------------ T_rubripes_ENSTRUP00000030183 VIFYL--RDKVVVGIILWNVFN-RMPIARKIIKDGEEHADLNEVAKLFNIHED------------------ T_nigroviridis_ENSTNIP00000014785 VIFYL--RDKVVVGIILWNVFN-RMPIARKIIKDGEEHADLNEVAKLFNIHED------------------ G_aculeatus_ENSGACP00000026857 VIFYL--RDKVVVGIILWNVFN-RMPIARKIIKDGEEHADLNEVAKLFNIHDD------------------ O_latipes_ENSORLP00000012070 VIFYL--RDKVVVGIILWNVFN-RMPIARKIIKDGEEHADLNEVAKLFNIHED------------------ G_gorilla_ENSGGOP00000007470 VIFYL--RDKVVVGIVLWNIFN-RMPIARK----------------------------------------- C_intestinalis_ENSCINP00000012225 VVFYL--RQQKVVGVLLWNVFG-RMPIARKMIRDQQAYDDYTEVAKLFKIHSEELD--------------- A_gambiae_AGAP008044-PA VIFYL--RDKKVVGLVLWNVFN-RMGTARKILDQHTEYDDLNEVAKLFNLHDRRTESEELEAAEQ------ A_aegypti_AAEL002016-PA VIFYL--KDEKVVGVLLWNVFN-RIGTARRIVAQHTRYDDLNEVAKLFNLHERPEEPEAEEKEQ------- T_guttata_ENSTGUP00000016816 ----------------------------------------------------------------------- D_melanogaster_FBpp0077504 VIFYL--KNDKIVGILLWNLFN-RIGLARTIINQNKKYDDLNEVAKLFEIHA------------------- C_elegans_Y56A3A.32.1 VVFYKSKEDGSIVGVLLLNVFGPSLDVARRIIDDRKKVDEYKEIAKLFPLYDPVKSDEDDAKSA------- O_anatinus_ENSOANP00000025948 ----------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000013415 VAFYT--KGDEVIA-ASMNYDP-IVS-VAEVLAS-RAIRKR-VELFVLH--SKTGDMSWLTGKGS------ P_troglodytes_ENSPTRP00000024275 VAFYT--KGDEVIAVASMNYDP-IVSKVAEVLASGRAIRKREVELFVLH--SKTGDMSWLTGKGS------ H_sapiens_ENSP00000382120 VAFYT--KGDEVIAVASMNYDP-IVSKVAEVLASGRAIRKREVELFVLH--SKTGDMSWLTGKGS------ T_guttata_ENSTGUP00000010972 VAFYT--KSDEVVAVASMNYDP-IVSKVAEVLAAGRTIRKRDVDTVDFLS-FRTGDMSWLTGKGT------ M_mulatta_ENSMMUP00000026974 VAFYT--KGDEVIAVASMNYDP-IVSKVAEVLASGRAIRKREVELFVLH--SKTGDMSWLTGKGS------ A_carolinensis_ENSACAP00000010903 VAFYT--KNDEVVAVASMNYDP-LVSKVADVMGAGRTIRKRDVELFIRY--GKIGDMSWLTGKGS------ T_nigroviridis_ENSTNIP00000021125 LAFYI--KDEKVVAAASLMFDP-AVARLAELMTSGQVITKTQAHLFVCV--CRAQDLAWLQMKSS------ C_intestinalis_ENSCINP00000015763 CAYYT--CKDQIVAIATMNSDP-VAADFAQRMLSGKAL--------------------------------- B_taurus_ENSBTAP00000053272 VAFYT--KGDEVISVASMNYDP-IVSKVAEVLASGRTIRKREVELFVLH--SKTGDMSWLTGKGS------ O_latipes_ENSORLP00000009976 VAFYT--RSEEVVAVASMNYDP-IVSRVVEVLGSGKTIKKRDVEMLARL--GKTGDISWLIDKGF------ G_gallus_ENSGALP00000012503 VAFYT--K--------------------------------------------------------------- D_rerio_ENSDARP00000085557 VAFYT--KSEEVVAVASMNYDP-IVSRVAEVFGSGKTIRKRDVE---------TGDMSWLIVKGSQ----- M_musculus_ENSMUSP00000111349 VAFYT--KSDEVIAVASMNYDP-IVSKVAEVLASGRAIRKREVELFMLH--SKTGDMSWLTGKGS------ G_gallus_ENSGALP00000039047 LIFYL--KD-------------------------------------------------------------- O_latipes_ENSORLP00000010037 LAFYI--KKDVVVAAASMTFDP-AVAQVAELMSKGNIITKAQAH-------PELYGMYVLTGRRE------ R_norvegicus_ENSRNOP00000048427 VAFYT--KGDEVIAVASMNYDP-IVSKVAEVLASGRAIRKREVELFMLH--SKTGDMSWLTGKGS------ T_rubripes_ENSTRUP00000040612 LAFYI--KEEKVVAAASLMFDP-AVARLAELMASGQTITKTQAQ-FPCV--FRAPDLAWLLIEGA------ G_aculeatus_ENSGACP00000012379 VAFYT--RGEEVVAVASMNYDP-IVSRVAEVLGSGKTIRKRDVEILARL--GKTGDISWLIDKGP------ T_nigroviridis_ENSTNIP00000018986 VAFYT--RSEEVVAVASMNYDP-IVSRVAEVLGSGKTIKKRDVDLASMST-SRTGDISWLIDKGS------ G_aculeatus_ENSGACP00000011210 LAFYI--KDEVVVAAASLMFDP-AVARVAELMATGQVISKAQAQ---------ADDLSWLQMNYS------ T_guttata_ENSTGUP00000005877 LIFYI--RDGRVTAAASLNCDP-MVSLIAEVFYLGKLISKEEAE--------------------------- D_melanogaster_FBpp0080714 VAYFFD-DYDKVTAVASCGRDP-MVAQFAELVSQGKELCRCQIV-------DPKGRNYWLTKLKL------ T_rubripes_ENSTRUP00000040932 VAFYT--RSEEVVAVASMNYDP-IVSRVAEVLGSGKTIKKRDVEKLVTLI-TWTGDISWLIDKGS------ X_tropicalis_ENSXETP00000057179 VAFYT--RNDEVIAVASMNYDP-IVSKVAEIMSSGKTIRKRDVEIFVCH--GKTGDISWLTGKGS------ A_carolinensis_ENSACAP00000014484 ----------------------------------------------------------------------- O_latipes_ENSORLP00000003241 LALYLNWRNDEVIAAAGLNFDP-AVSAVAERLSSGKVITKKEAQYYVFD--GKTESAASVNRSAS------ G_aculeatus_ENSGACP00000027082 LALYI--KNDEVVAAASLNYDP-AASAVAERFAAGKVITKKEAEYAVFD--ARWGGASWKQPKWP------ T_nigroviridis_ENSTNIP00000019217 LVLYI--KDDAVVAAGSLNYDP-AVSAVAQRLMAGKVITKEEAQ--------------------------- C_elegans_F20D6.11 IRYFL--KKDKVVAVAAGGPSS-VASQFAEIFKKGIEVTLKDLK--------NSSDHTWGHLLL------- T_rubripes_ENSTRUP00000030429 LALYI--KNDAVIAAVSLNYDP-AVSAVAQRLIAGKVITKEEAQLCSVS--SKTQANLMATGGS------- D_melanogaster_FBpp0070319 VAYFIN-EADTVTAVASCGRDP-IVAQFAELISQGKCLGRGQIE-------DPATREDWTKKLGQPLPQVR A_aegypti_AAEL011158-PA VAFYLD-ANGKVIGMASCGRDP-VVSQFAEYLSQGKTFHKDQLS---------PDPFAWIK----------