10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000306822 MQAERGAR--GGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRG-RGRGFRG------------ARGGRGGGGAPR-----GSRREPGGWG-AGASAP------VEDD P_troglodytes_ENSPTRP00000011744 MQAERGAR--GGRGRRPGRGRPGGDRHNERPGAAAAVAR----GGGGDGGGRRGRG-RGRGFRG------------ARGGRGGGGAPR-----GSRREPGGWG-AGASAP------VEDD P_pygmaeus_ENSPPYP00000007145 MQAERAAR--GGRGRRPGRGRPGGDRHSERPGAAAAVAR----GGGGDGGGR--RG-RGRGFRG------------ARRGRGGGGAPR-----GSRREPRGWD-LGASAP------VEDD M_mulatta_ENSMMUP00000006979 MQAERGAR--GGRGRRPGRGRPGGDRHNERPGAAAAVAR----GGGGDGGGR--RG-RGRGFRG------------ARGGRGGGGAPR-----GSRREPGGRG-AGTSAP------VEDD M_musculus_ENSMUSP00000003705 MQAERGAR--GGRGRRGGRERPGGDR--EPVGAATALAR----GGCGDGGGR--RG-RGRGF---------------RRGR-GGGGLR-----GGRWEPGGRG-GGASTR------VEED B_taurus_ENSBTAP00000053243 MQAERGAR--GGRGRRPGRGRPGGDRDRERAGAGTAVAR----GGGGDGGGR--RG-RGRGFRG------------GRGGR-GGGAPR-----GGRREPGGWG-ARTSEP------IEDD R_norvegicus_ENSRNOP00000008664 MQAERGAR--GGRGRRGGRERPGGDR--GPAGAATALAR----GGCGDGGGR--RG-RGRGF---------------RRGR-GGGAPR-----GGRREPGGRG-GGASTR------VEED G_gorilla_ENSGGOP00000008984 MQAERGAR--GGRGRXXGRGRPGGDRHSERPGAAAAVAR----GGGGDGGGRRGRG-RGRGFRG------------ARGGRGGGGAPR-----GXRREPGGWG-AGASAP------XXXX M_domestica_ENSMODP00000002009 ----------------------------------------------------------------------------GRGGRGGGGASAHGAQLGGRREQQGRG-SGPSEL------VEGD O_cuniculus_ENSOCUP00000009891 --------------------------------------------------------------------------------------------------------------------VEDD G_gallus_ENSGALP00000015688 MQPERGGSRPRREGGRHGRRRPGGAEKAAEPATESGGAD----GHGRGGTGGRGRG--GAHGHR------------GGGGR-------------GKREPRGRG-AAPLTAPHHQRRVEDD C_familiaris_ENSCAFP00000011833 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000015117 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000011995 ------------------------------------------------GAGSRRRT-GRAGGRA------------GGGGR-------------GQCAARIAP-CRSVPAVRGARRVEED X_tropicalis_ENSXETP00000054921 EHMERGRGRHRRGGG--GRRRPWGERGR---------------GGDRVGPAHSGRGYRGADRQRNEPSEPRIEVRTGRGGRPVGRKG-------GHLRPEGRR-VGAKGP------VLQD D_rerio_ENSDARP00000010975 MESAHNSRGRGGHWKR---------------------------GGGGDAGEHRGRG-RGGHQHR------------GRGKR-------------DHRRGRGRE-HGPPADFRDFRRNQDE T_rubripes_ENSTRUP00000046343 MEGRQNSGR-GGSWKKVDR-------------------------GAINSGEHRGRG-RGSH-HR------------GRGKR-------------NYYRGHGRG-ENIHAFHPPFTSNLDE G_aculeatus_ENSGACP00000010511 ----------GGS------------------------------NGESVGGEQRGRG-RGGH-HR------------GRGKR-------------DHYRGRGRGGSGPSADFQHRDKGEDE T_nigroviridis_ENSTNIP00000002172 ----------GRSWKKVDR------------------------SGNNNNDEHRGRG-RGGH-HR------------GRGKR-------------DHYRGRGRG-ESVHALHH------RE O_anatinus_ENSOANP00000028204 ----ASRGKLTGEAGRPSRTIRPGAPSGTVSNPPR--------GGGGGESIQGGPG-RGRSWEVVESE--------SRRGRSPGAANS---GQRAWPDPSVWG-GGGDPP---FLNEEEE 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000306822 SDAET-YGEENDEQG-NYSKRKIVSNWDRYQDIEKEVNNESGESQRGTDFSVLLSSAGDSFSQFRFAEEKEWDSEASCPKQ-NSAFYVDSELLVRALQELPLCLRLNVAAELVQGTVPLE P_troglodytes_ENSPTRP00000011744 SDAET-YGEENDEQG-NYSKRKIVSNWDRYQDIEKEVNNESGESQRGTDFSVLLSSAGDSFSQFRFAEEKEWDSEASCPKQ-NSAFYVDSELLVRALQELPLSLRLNVAAELVQATVPLE P_pygmaeus_ENSPPYP00000007145 SDAET-CGEENDEQG-NYSKRKIVSNWDRYQDIEKEVNNESGESQRGTDFSVLLSSAGDSFSQFRFAEEKEWDSEASCPKQ-NSAFYVDSELLVQALQELPLSLRLNVAAELVQATVPLE M_mulatta_ENSMMUP00000006979 SDAET-YGEENDEQG-NYSKRKIVSNWDRYQDIEKEVNNESGESQRGTDFSVLLSSAGDSFSQFRFAEEKEWDTEASCPKQ-NSAFYVDSELLVRALQELPLSLRLNVAAELVQATVPLE M_musculus_ENSMUSP00000003705 SDSET-YGEENDEQG-NFSRRKIVSNWDRYQDTEKEVNGESGESQRGTDFSVLLSSAGDSFSQFRFAEEKEWDGETSCPKQ-NSALYVDSESLVRALEQLPLAVRLNVASELIQTTIPLE B_taurus_ENSBTAP00000053243 SDAET-YGEENEEQG-NYSKRKIVSNWDRYQDTEKEVDNESGESQRGTDFSVLLSSAGDSFSQFRFAEEKEWDGEASCPKQ-NSAFYVDCESLVRALQELPLSLRLNVAAELVQTALPLE R_norvegicus_ENSRNOP00000008664 SDSET-YGEENDEQG-HFSRRKIVSNWDRYQDTEKEVNGESGESQRGTDFSVLLSSAGDSFSQFRFAEEKEWDGETSCSKQ-NSALYVDSESLVRALQQLPLAVRLNVASELIQTAVPLE G_gorilla_ENSGGOP00000008984 XXXXX-XXXXXXXXX-XXXXXXXXXNWDRYQDIEKEVNNESGESQRGTDFSVLLSSAXXXFSQFRFAEEKEWDSAASCPKQ-NSAFYVDSELLVRALQELPLSLRLNVAAELVQATVPLE M_domestica_ENSMODP00000002009 -ETES-YEEENNEWG-NYSRRKIVSNWDRYQDFEKEAENESGESQRGTDFSVLLSSAGDSFSQFRFAEEKEWDTEASSPKQ-ISAFYVDCEALVRALQELPLSFRLNVAAELVQATAPLE O_cuniculus_ENSOCUP00000009891 SDTET-YGGENDEQG-NYSRRKIVSNWDRYRDS-KEVNNEGGESQRGTDFSVLLSSAGDSFSQFRFAEEKEWDSEASCPKQ-NSAFYLDSESLVRALQELPLSLRLNVAAELVQSTVPLE G_gallus_ENSGALP00000015688 GDTES--REEEEEVK-NYSRRKIVSNWNRYEDAEKEGQTECGESQRGTDFSVLLSSAGDSFTQFRFAEEKDWDTENVYCKQ-LSALSVDCQSLAQALQELPLHLRLNVAAELVQALTPVE C_familiaris_ENSCAFP00000011833 ---------------------------------------------------------GDSFSQFRFVEEKEWDGEVSGPKQ-NSAFYVDCESLVRALQELPLSLRLNVAAELVQTALPLE A_carolinensis_ENSACAP00000015117 --------------G-GYSCRKVVSNWHRYEDTEKETQNDSGESQRGTDYSVLLSSAGDSFTQFRFAEEKEWIVENFCPKQ-LSGLYVDCQSLVKALEELPLHVKLNVAAELVQEATPVV T_guttata_ENSTGUP00000011995 DDTESRHEEEKEEVR-CYSRRKVFSNWSRYEDTEKEGQSEAGESQRGSDFSVLLSSAGNSFTQFRFADEKEWDKESICHKQ-FSALSVDCQSLVQALQELPLHLRLNIAADLVQASTPLE X_tropicalis_ENSXETP00000054921 RNEAVEPQEEDEQVSLGFSRRKISSNWDRYEETEKESESESKVLQRGADYSVLLSSAGDSFTQFRFADEKDWEAETPSYKQ-ASAVCLDPQSLVRVLQELPLHLRLNVEPELVQEVLPQE D_rerio_ENSDARP00000010975 PDDKE-NVEDMEEDN-TFNRRKLESNWDRYKESEKEEMNEDVPAQRGTDYHVLLTSAGDSFTQFRFSDEKDWELDLLAKNQ-IPALFIDLPALSESLQELPLHTRLNLEAELIQESTPVD T_rubripes_ENSTRUP00000046343 QSEEEGHQDDDCGLG-NFSRRKLESNWDRYKQSEKPDSGDDIPTRRGTDYHVLLESAGDSFTQFRFSEEKEWDMDSFAASQ-PSTAFVDLIALAQILQELPVHQRLNLDADLGQVLTPSH G_aculeatus_ENSGACP00000010511 GDN---FQEEGDRKE-VFSRRKLASNWDRYEASEREEPDEDTPTQRGTDYHVLLESAGDCFTQFRFSEEKEWEMDS-AASQ-MSAVFVDLPALAEILQQVPLHQRLNLEAELLQVGRLLE T_nigroviridis_ENSTNIP00000002172 QDEEESSQEEDCGVE-GFSRRKLESNWDRYEEPETE-EAEDRPTRRGADYQLLLESAGNSFAQFRFSEEKVWDEDSFAASQ-PSAVCVDLPALVQILQELPLHQRLNLEAELEQVAPPSQ O_anatinus_ENSOANP00000028204 EEEGKDKGEEEEEWS-GFSRRKIVSNWDRYKDSEKEPEPD---TRRGVEFDVLLTSAGDSFSQFRFAEEKEWDSDPFLLKQLAPAVFVNCEALADALQRL-------------------- 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000306822 VPQVKPKRTDDGKGLGMQLKGPLGPGGRGPIFELKSVAAGCPVLLGKDN--PSPGPSRDSQKPTSPLQSAGDH--LEEELDLLLNLDAPIKEGDNILPDQTSQDLKSKEDGEVVQEEEVC P_troglodytes_ENSPTRP00000011744 LPQVKPKRTDDGKGLGMQLKGPLGPGGRGPIFELKSVAAGCPVLLGKDN--PSPGPSRDSQKPTSPLQSAGDH--LEEELDLLLNLDAPIKEGDNILPDQTSQDLKSKEDGEVVQEEEVC P_pygmaeus_ENSPPYP00000007145 LPQVKPKRTDDGKGLGMQLKGPLGPGGRGPIFELKSVAAGCPVLLGKDN--PSPGPSRDSQKRTSPLQSAGDH--LEEELDLLLNLDAPIKEGGNILPDQTSQDLKSKEDGEVVQEEEVC M_mulatta_ENSMMUP00000006979 LPQVKPKRTDDGKGLGMQLKGPLGPGGKGPISELKSAAAGCPVLLGTDN--PRPGPSTDSQKPTSPLQSAGDH--LEEELDLLLNLDAPVKEGDNILPDQTSQDLKSKKDGEVVQEEEVC M_musculus_ENSMUSP00000003705 LPQVKPRRNDDGKELGMHLRGPI--------SELRSAAGACPRSLGRGS--LRQSPLEGLQKAPTPTQSVADH--LEEELDMLLHLDAPVQEEGNISPDQTSRDQEPEKDGQVAQEETGP B_taurus_ENSBTAP00000053243 LPQVKPKRNNDGKGLGMQLKGPSGPGGKGSLSEMKSTTTGFPVYPGKDG--PGSGPSKGCQNPTSLLQLAADH--LEEELDLLLNLDAPVKEGGDILSDQTAQDLESEKRGDLVQAAAEP R_norvegicus_ENSRNOP00000008664 LPQAKPRRNDDGKELGMQLRGPL--------SQLRSAAGGCPRSLGRDS--LRQSPSEGSQKASSPPQSAADH--LEEELDMLLHLDAPVKEEDSLSPDQTSQDQEPERDGQIAQEEIAP G_gorilla_ENSGGOP00000008984 LPQVKPKRTDDGKGLGMQLKGPLGPGGRGPIFELKSVAAGCPVLLXKDN--PSPGPSRDSQKPTSPLQSAGDH--LEEELDLLLNLXAPIKEGDNILPDQTSQDLKSKEDGEVVQEEE-- M_domestica_ENSMODP00000002009 LPQMKPKKMEESKGLGMQMRWPVGPG-----SDVISDAANCPVPTGKDG--PRPCSSEAFQKITPPLQQTVDH--LDEELDLLLNLDAPIKEEHNALIAQTHQDPKAKKDGRKIQEETVP O_cuniculus_ENSOCUP00000009891 LPQVKPKRPDDSKGTGMQLKGSL--------SELRSAA--CPGPLG---------PSSGPQKPASSPESAADH--LEEELDLLLNLDAPVKEEDNLL-GKTSQDLKPEEDGEMAQEEKVP G_gallus_ENSGALP00000015688 LPQMKSKVVEDSKRRE-LFRQSLSQRETALVSQSVGDSATSSEPGSKRG--PVTSAAEPFQRAHLLAKQETDH--LDEELDRLLNLDAPIDS----VSGALSYNISTEKDLKMESKENDP C_familiaris_ENSCAFP00000011833 LPQMKPKRNDEAKGLGMQLKGPLGPGGKGSVSELKPAA-CCP------------APSGGPQKPTAPLPSAADH--LEEELDLLLSLDAPVRDGESILPDLTP-GLESEKDRDMAQEGQGP A_carolinensis_ENSACAP00000015117 LPQIKLKSSDVPRRSGGPLQQTLGQSTGSSGPFPAADSATQLTGPHKDG--PGINSEGPPKNLSSLC-QERDN--LDEDLDLLLKLDAPVNPENCMGLEILSHDTVSGEDLKMSHEENSC T_guttata_ENSTGUP00000011995 IPQMKSKIFEDGKKREQLFRQSLAQSETVLVSHPLGNSVAPSEPGSKNG--SGGNAGESFQRVHPLSNQDTDH--LDEELDLLLNLEAPINTENRPASGTLSYSISTEKDLKMDCKENEP X_tropicalis_ENSXETP00000054921 LPHFKTRDI--------LITPPVIQA-----PPSTGAASSTQVGMAPPE--EQVSNTTRAQDSSPQLE-------LDEELDFLLSLEAPVKEAAGVKP----TNEEKECDLHGKRQELLP D_rerio_ENSDARP00000010975 LPPMTVSHRTDLTGTAGLKAPPAG----------RESSLGVPCSVKP------ISGSTVSVSISTTIPPDDDE--DDQELHLLLNLQKPVTELPSVQSHTTANDVLNNTVQAALSEEEVK T_rubripes_ENSTRUP00000046343 LPAVSFTPKPEVSKLD--FAPPLA--------EFRKLATKVPAVTKAHT---------PVSSNTAASPPAEDD--DEEELDQLLNLKKPVVGNQQ-DTGAEEENPAPEKDCEDVKEVTEK G_aculeatus_ENSGACP00000010511 CPPEDKKRLTNHTVLLFLSQISTPLELPGLTLPVKQAMAKTATFTLPSAALKIVSSSDPPVSSSAAEPPVD----DDEELDQLLSLQKPVWH----DSGGQSVSVAPKRAVLTEEKT--- T_nigroviridis_ENSTNIP00000002172 RPAVDFTPKQEASPPD--FAPPLA--------DFKKLIAKAPAAVDPDA---------PVSSTTAAFPPGDDDDYDDEELDQLLNLKKPAAANQS-GTGEDEEEPVSEKGCEDVKEVTKK O_anatinus_ENSOANP00000028204 ------------------------------------------------------------------------------------------------------------------------ 370 380 390 =========+=========+=========+======== H_sapiens_ENSP00000306822 AKP-SVTEEKNMEPEQP-STSKNVTEEELEDWLDSMIS P_troglodytes_ENSPTRP00000011744 AKP-SVTEEKNMEPEQP-STSKNVTEEELEDWLDSMIS P_pygmaeus_ENSPPYP00000007145 AKP-SVTEEKNMEPEQP-STSKNVTQEELEDWLDSMIS M_mulatta_ENSMMUP00000006979 AKP-SVTEEKNVEPEQP-STSRHVTEEELEDWLDSMIS M_musculus_ENSMUSP00000003705 EKP-SVTREKNVEPEQP-STSKNVTEEELEDWLDSMIS B_taurus_ENSBTAP00000053243 ANP-FVLEEKNVTSGQP-SISRNVTEEELEDWLDSMIS R_norvegicus_ENSRNOP00000008664 EKP-SVTRDKTVEPGQP-STSKTVTEEELEDWLDSMIS G_gorilla_ENSGGOP00000008984 -------------------------------------- M_domestica_ENSMODP00000002009 EKL-SVTKEKKLESEQPACTSKNVTEEELEDWLDSMIS O_cuniculus_ENSOCUP00000009891 AKP-SGAEEKNVEPEQG-STSKTVTEEELEDWLDSMIS G_gallus_ENSGALP00000015688 PTA-DVPEEKSTALQQEQKTSKIVTEEELEDWLDSMIS C_familiaris_ENSCAFP00000011833 AEP-SVTDEKNVQSEQP-STSKPVTEEELEDWLDSMIS A_carolinensis_ENSACAP00000015117 LQL-DGTEEICSASQQE-GTSKSITEEELEDWLDSMIS T_guttata_ENSTGUP00000011995 LKV-DMPEDKGTSSQQQENTSKDVTEEELEDWLDSMIA X_tropicalis_ENSXETP00000054921 --------ITDEDASSSAEKNKSVTEEDLEDWLDSMIS D_rerio_ENSDARP00000010975 KAAGDMKDMKSEVEIEPKPQKQEVTEEDLEDWLDSMIS T_rubripes_ENSTRUP00000046343 ----EVVKGKDITPPEPTSVRKEVTEEDLEDWLDSMIS G_aculeatus_ENSGACP00000010511 ----DEVKNKDVNPRESASVRQEMTEEDLEDWLDSMIS T_nigroviridis_ENSTNIP00000002172 K---ETATENDITPPEPTSAGKEVTEEDLEDWLDSMIS O_anatinus_ENSOANP00000028204 --------------------------------------