>H_sapiens_ENSP00000309591 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNAAAA--KKGSEQ-------------E-------------------- --------------------------------------------S----VKEFLAK---A KEDFLKK---WESP--AQNTA-HLDQFERIKTLGTGSFGRVMLVKHKETGNH-YAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKG---PGDTSNFD DYEEEEIRVS--INEKCGKE-------------FSEF----------------------- ------------------------------------------------------------ ----- >B_taurus_ENSBTAP00000008727 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNAAAA--KKGSEQ-------------E-------------------- --------------------------------------------S----VKEFLAK---A KEDFLKK---WENP--AQNTA-HLDQFERIKTLGTGSFGRVMLVKHMETGNH-YAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKG---PGDTSNFD DYEEEEIRVS--INEKCGKE-------------FSEF----------------------- ------------------------------------------------------------ ----- >M_musculus_ENSMUSP00000005606 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNAAAA--KKGSEQ-------------E-------------------- --------------------------------------------S----VKEFLAK---A KEDFLKK---WETP--SQNTA-QLDQFDRIKTLGTGSFGRVMLVKHKESGNH-YAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKG---PGDTSNFD DYEEEEIRVS--INEKCGKE-------------FTEF----------------------- ------------------------------------------------------------ ----- >P_troglodytes_ENSPTRP00000018062 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------ASNS-------------S-------------------- --------------------------------------------D----VKEFLAK---A KEDFLKK---WESP--AQNTA-HLDQFERIKTLGTGSFGRVMLVKHKETGNH-YAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKG---PGDTSNFD DYEEEEIRVS--INEKCGKE-------------FSEF----------------------- ------------------------------------------------------------ ----- >C_familiaris_ENSCAFP00000024262 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S----VKEFLAK---A KEDFLKK---WENP--AQNTA-HLDQFERIKTLGTGSFGRVMLVKHKETGNH-FAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKG---PGDTSNFD DYEEEEIRVS--INEKCGKE-------------FTEF----------------------- ------------------------------------------------------------ ----- >E_caballus_ENSECAP00000014954 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------ASNP-------------N-------------------- --------------------------------------------D----VKEFLAK---A KEDFLKK---WENP--AQNTA-HLDQFERIKTLGTGSFGRVMLVKHKETGNH-FAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVNFPFLVKLEFSFKDNSNLYMIMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQHGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKG---PGDTSNFD DYEEEEIRVS--INEKCGKE-------------FSEF----------------------- ------------------------------------------------------------ ----- >G_aculeatus_ENSGACP00000024909 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNAPTA--RKGSEM-------------E-------------------- --------------------------------------------S----VKEFLAK---A KEDFLKK---WESP--AQNTA-GLEQFERLKTLGTGSFGRVMLVKHRETGQH-YAMKILN -KQKVVKLKQIEHTLNEKRI-L---QAVSFPFLVRLEYSFKDNTNLYMVMEYVPGGEMFS HLRRIGRFSVHSEPHARFYAAQIVLTFEYLHALDLIYRDLKPENLLIDQQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLVYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVNDIKGHKWFATTDWIAIYQKKVEAPFVPKFKG---PGDTSNFD DYEEEEIRVS--FNEKCGKE-------------FAEF----------------------- ------------------------------------------------------------ ----- >T_rubripes_ENSTRUP00000013710 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNAPTA--RKGSEM-------------E-------------------- --------------------------------------------S----VKEFLAK---A KEDFLKK---WENP--AQNTA-CLEQFERLKTLGTGSFGRVMLVKHRETGQH-YAMKILN -KQKVVKLKQIEHTLNEKRI-L---QAVSFPFLVRLEYSFKDNTNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHALDLIYRDLKPENLLIDQQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLVYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRYGNLKNGVNDIKGHKWFATTDWIAIYQKKVEAPFIPKFKG---PGDTSNFD DYEEEEIRVS--FTEKCAKE-------------FAEF----------------------- ------------------------------------------------------------ ----- >T_nigroviridis_ENSTNIP00000013350 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNTPTT--KKGNEM-------------E-------------------- --------------------------------------------S----VKEFLAK---A KEDFLKK---WENP--AQQTA-ALDHFDRLKTLGTGSFGRVMLVKHKETGQH-FAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVNFPFLVCLEHSFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLRNGVNDIKGHKWFATTDWIAIYQRKVEAPFIPKCKG---PGDTSNFD DYDEEEIRVS--FTEKCAKE-------------FAEF----------------------- ------------------------------------------------------------ ----- >G_aculeatus_ENSGACP00000013822 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNTPTA--KKGNEM-------------E-------------------- --------------------------------------------S----VKEFLAK---A KEDFLKK---WENP--AQQTA-ALDHFERLKTLGTGSFGRVMLVKHKESGQH-FAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVSFPFLVRLEHSFKDNSNLYMIMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLRNGVNDIKGHKWFATTDWIAIYQRKVEAPFIPKCKG---PGDTSNFD DYEEEEIRVS--FTEKCAKE-------------FAEF----------------------- ------------------------------------------------------------ ----- >D_rerio_ENSDARP00000076580 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNAATA--KKGNEL-------------E-------------------- --------------------------------------------S----VKEFLAK---A KEDFLRK---WESP--QQSTT-CLDDFDRQKTLGTGSFGRVLLVKHKASDQY-YAMKVLD -KQKVVKLKQVEHTLNEKRI-L---QAVSFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQHGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLRNGVNDIKNHKWFATTDWIAIYERKVEAPFIPKCRG---PGDTSNFD DYEEEDIRVS--VTEKCAKE-------------FSEF----------------------- ------------------------------------------------------------ ----- >T_rubripes_ENSTRUP00000032222 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CDRKSS--RRHAVC-------------F-------------------- --------------------------------------------SSECLVKEFLAK---A KEDFLKK---WENP--AQQTA-ALDHFERLKTLGTGSFGRVMLVKHKESGQH-FAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVNFPFLVCLEHSFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLRNGVNDIKGHKWFATTDWIAIYQRKVEAPFIPKCKG---PGDTSNFD DYEEEEIRVS--ITEKCAKE-------------FAEF----------------------- ------------------------------------------------------------ ----- >T_rubripes_ENSTRUP00000026750 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNAATA--KKGNEL-------------E-------------------- --------------------------------------------S----VKEFLAK---A KEDFLRK---WECP--PQSTT-CLDDFDRLKTLGTGSFGRVMLVKHKGTEQY-FAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVSFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHHGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRYGNLKNGVNDIKGHKWFATTDWIAIYERKVEAPFIPKCRG---PGDTSNFD DYEEEEIRVS--LTEKCAKE-------------FAEF----------------------- ------------------------------------------------------------ ----- >D_rerio_ENSDARP00000013244 Y----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AHNHTL--SLSLSL-------------C-------------------- --------------------------------------------T----VKEFLAK---A KEDFLKK---WENP--AQNTA-SLDHFERLKTLGTGSFGRVMLVKHKESGQH-FAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVSFPFLVRLEHSFKDNTNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVNDIKGHKWFATTDWIAIYQKKVEAPFIPKCKG---PGDTSNFD DYDEEEIRVS--ITEKCGKE-------------FAEF----------------------- ------------------------------------------------------------ ----- >T_nigroviridis_ENSTNIP00000011358 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNAATA--KKGNEL-------------E-------------------- --------------------------------------------S----VKEFLAK---A KEDFLRK---WECP--PQSTT-CLDDFDRLKTLGTGSFGRVMLVKHKGTEQY-FAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVSFPFLVKLEYAFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHHGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRYGNLKNGVNDIKGHKWFATTDWIAIYERKVEAPFIPKCRG---PGDTSNFD DYEEEEIRVS--LTEKCAKE-------------FAEF----------------------- ------------------------------------------------------------ ----- >D_rerio_ENSDARP00000002825 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNTPAA--KRGNEM-------------E-------------------- --------------------------------------------S----VKEFLAF---A KEDFLRK---WENP--AQNTA-CLEDFDRLKTLGTGSFGRVMLVRHRETGQH-YAMKILN -KQKVVKLKQIEHTLNEKRI-L---QAVSFPFLVRLEYSFKDNTNLYMVMQYVQGGEMFS HLRRIGRF---SEPHARFYASQIVLTFEYLHALDLIYRDLKPENLLIDQQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLMYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRYGNLKNGVNDIKGHKWFSTTDWIAIYQRRVEAPFVPKCRG---PGDTSNFD DYEEEEIRVS--FTEKCAKE-------------FAEF----------------------- ------------------------------------------------------------ ----- >O_latipes_ENSORLP00000021647 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNAATA--KKGNEL-------------E-------------------- --------------------------------------------S----VKEFLAK---A KEDFLRK---WECP--PQSTT-CLEDFDRIKTLGTGSFGRVMLVKHKSSEQY-FAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVSFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHHGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRYGNLKNGVNDIKGHKWFATTDWIAIYERKVEAPFIPKCRG---PGDTSNFD DYEEEEIRVS--LTEKCAKE-------------FAEF----------------------- ------------------------------------------------------------ ----- >G_aculeatus_ENSGACP00000012693 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNAATA--KKGNEQ-------------E-------------------- --------------------------------------------S----VKEFLAK---A KEDFLRK---WECP--PQSTT-GLDDFDRFKTLGTGSFGRVMLVKHKESNQF-YAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVSFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEHHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQHGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVNDIKNHKWFSQTDWIAIYERKVEAPFLPKCRG---PGDTSNFD DYEEEDIRVS--QTEKCAKE-------------FAEF----------------------- ------------------------------------------------------------ ----- >T_rubripes_ENSTRUP00000015108 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNAATA--KKGNEQ-------------E-------------------- --------------------------------------------S----VKEFLAK---A KEDFLRK---WECP--QQCTT-GLDDFDRFKTLGTGSFGRVMLVKHKETNQF-YAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVSFPFLVRLVYSFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEHHARFYAAQIILTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVNDIKNHKWFSTTDWIAIYEKKVEAPFLPKCRG---PGDTSNFD DYEEEDVHVS--QTEKCAKE-------------FADF----------------------- ------------------------------------------------------------ ----- >G_gallus_ENSGALP00000014351 MAAQKE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VPCAQCTGTATALQRLE GFANRLFHRHSKGGAHDL--RVPLENESHHVSELAVLWDK-------------------- --------------------------------------------S----MKEFLAK---A KEDFLRK---WESP--PQNTA-GLDDFERQKTLGTGSFGRVMMVKHKATEQY-YAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRYGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKCRG---PGDTSNFD DYEEEDIRAS--LTEKCAKE-------------FADF----------------------- ------------------------------------------------------------ ----- >G_aculeatus_ENSGACP00000023579 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNAATA--KKGNEL-------------E-------------------- --------------------------------------------S----VKEFLAK---A KEDFLRK---WECP--PQSAT-CLDDFDRLKTLGTGFLWRVMLVKHKATEQH-FAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVSFPFLVKLEYAFKDTSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHHGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRYGNLKNGVNDIKGHKWFATTDWIAIYERKVEAPFIPKCRG---PGDTSNFD DYEEEEIRVS--VTEKCGKE-------------FAEF----------------------- ------------------------------------------------------------ ----- >X_tropicalis_ENSXETP00000018929 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S----VKEFLAK---A KEDFLRK---WETP--PQNTA-SLDDFERIKTLGTGSFGRVMLVKHKGAEQY-YAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVNFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRYGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKCRG---PGDTSNFD DYEEEDIRVS--LTEKCAKE-------------FADF----------------------- ------------------------------------------------------------ ----- >T_guttata_ENSTGUP00000006845 MAGHTE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VPCSQGSGTATALQRLE GFANRLFHRHSKNGAHEQ--RAALEGESQQCSEFTVQWDK-------------------- --------------------------------------------S----MKEFLAK---A KEDFLRK---WESP--PQNTA-GLDDFERQKTLGTGSFGRVMMVKHKSTEQY-YAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRYGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKCRG---PGDTSNFD DYEEEDIRAS--LTEKCAKE-------------FADF----------------------- ------------------------------------------------------------ ----- >O_latipes_ENSORLP00000008832 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------AAIF--THNMFL-------------F-------------------- --------------------------------------------A----VKEFLAK---A KEDFLKK---WENP--AQQTA-ALDHFERLKTLGTGSFGRVMLVKHKETGQH-FAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVSFPFLVQLEHSFKDTSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLRNGVNDIKGHKWFATTDWIAIYQRKVEAPFIPKCKG---PGDTSNFD DYEEEEIRVS--FSEKCAKE-------------FAEF----------------------- ------------------------------------------------------------ ----- >O_latipes_ENSORLP00000018527 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------NAAQQ--PSNSVR-------------D-------------------- --------------------------------------------K----VKEFLAK---A KEDFLKK---WENP--SQNTA-NLEQFERLKTLGTGSFGRVMLVKHRETGQH-YAMKILN -KQKVVKLKQIEHTLNEKRI-L---QAVSFPFLVRLEFSFKDNTNLYMVMEYVPGGEMFS HLRKIGRF---SEPHARFYATQIVLTFEYLHALDLIYRDLKPENLLIDQQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLVYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRYGNLKNGVNDIKGHKWFAATDWIAIFQKKVEAPFVPKFKG---PGDTSNFD DYEEEEIRVS--FSEKCAKE-------------FAEF----------------------- ------------------------------------------------------------ ----- >A_carolinensis_ENSACAP00000005713 MAAQKE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LQGNPSTGTANALQRLE GFANRLFHRHSKGSSSEL--KAAQENESPHFSELAALWER-------------------- --------------------------------------------S----MKEFLAK---A KEDFLRK---WESP--PQNTA-GLEDFERLKTLGTGSFGRVMLVKHKATEQY-YAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVNFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRYGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKCRG---PGDTSNFD DYEEEDIRVS--LTEKCAKE-------------FADF----------------------- ------------------------------------------------------------ ----- >O_latipes_ENSORLP00000007943 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNTATA--KKGNEQ-------------E-------------------- --------------------------------------------S----VKEFLAK---A KEDFLRK---WECP--PQCTT-SLDDFERFKTLGTGSFGRVMLVKHKATNQF-YAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVSFPFLVRLVYAFKDNSNLYMVMEYVPGGEMFS HLRRTGRF---SEHHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQHGYIQVTDFGF AKK-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVNDIKNHKWFSTTDWIAIYERKIEAPFLPKCRG---PGDTSNFD DYEEEDIHVS--QTEKCGKE-------------FADF----------------------- ------------------------------------------------------------ ----- >E_caballus_ENSECAP00000020287 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------SARKSSEAS--ACSSSE-------------V-------------------- --------------------------------------------S----VKEFLAK---A KEDFLKK---WENP--AQNNA-GLEDFERKKTLGTGSFGRVMLVKHKATEQY-YAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVNFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRG---SGDTSNFD DYEEEDIRVS--ITEKCAKE-------------FCEF----------------------- ------------------------------------------------------------ ----- >H_sapiens_ENSP00000359719 MAAYRE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PPCNQYTGTTTALQKLE GFASRLFHRHSKGTAHDQ--KTALENDSLHFSEHTALWDR-------------------- --------------------------------------------S----MKEFLAK---A KEDFLKK---WENP--TQNNA-GLEDFERKKTLGTGSFGRVMLVKHKATEQY-YAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRG---SGDTSNFD DYEEEDIRVS--ITEKCAKE-------------FGEF----------------------- ------------------------------------------------------------ ----- >P_pygmaeus_ENSPPYP00000001399 MAAYRE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PPCNQYTGTSTALQKLE GFASRLFHRHSKGTAHDQ--KTALQNDSLHFSEHTALWDR-------------------- --------------------------------------------S----MKEFLAK---A KEDFLKK---WENP--TQNNA-GLEDFERKKTLGTGSFGRVMLVKHKATEQY-YAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRG---SGDTSNFD DYEEEDIRVS--ITEKCAKE-------------FGEF----------------------- ------------------------------------------------------------ ----- >P_troglodytes_ENSPTRP00000042330 MAAYRE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PPCNQYTGTTTALQKLE GFASRLFHRHSKGTAHDQ--KTALENDSLHFSEHTALWDR-------------------- --------------------------------------------S----MKEFLAK---A KEDFLKK---WENP--TQNNA-GLEDFERKKTLGTGSFGRVMLVKHKATEQY-YAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRG---SGDTSNFD DYEEEDIRVS--ITEKCAKE-------------FGEF----------------------- ------------------------------------------------------------ ----- >M_musculus_ENSMUSP00000005164 MAAHKE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LSSGQHSGTPTALQKLE GFASRLFHRHSRGTAQEH--RAALEDDGLRASEHTASWDK-------------------- --------------------------------------------S----MKEFLAK---A KEDFLRK---WENP--PPSNA-GLEDFERKKTLGTGSFGRVMLVKHKATEQY-YAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVEFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRG---SGDTSNFD DYEEEEIRVS--ITEKCGKE-------------FCEF----------------------- ------------------------------------------------------------ ----- >T_nigroviridis_ENSTNIP00000017048 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNAPTA--RKGSEM------------ES-------------------- --------------------------------------------E----SRNSLPN---A KEDFLKK---WENPCTVQNTA-CLEQFERLKTLGTGSFG-VMLVKHRETGQH-Y-MKISN -KQKVVKLKQIEHTLNEKRI-L---QAVSFPFLVRLEYSFKDNTNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHALDLIYRDLKPENLLIDQQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLVYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRYGNLKNGVNDIKGHKWFATTDWIAIYQKKVEAPFIPKFKG---PGDTSNFD DYEEEEIRVS--FTEKCAKE-------------FAEF----------------------- ------------------------------------------------------------ ----- >M_mulatta_ENSMMUP00000004604 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S----VKEFLAK---A KEDFLKK---WENP--TQNNA-GLEDFERKKTLGTGSFGRVMLVKHKATEQY-YAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRYGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRG---SGDTSNFD DYEEEDIRVS--ITEKCAKE-------------FGEF----------------------- ------------------------------------------------------------ ----- >R_norvegicus_ENSRNOP00000043572 MAAHKE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LSFGQHTGTPTALQKLE GFASRLFHRHSKGTAQDQ--KAALEEEGLQASEHTASWDK-------------------- --------------------------------------------P----MKEFLAK---A KEDFLRK---WENP--PPSNA-GLEDFERKKTLGTGSFGRVMLVKHKATEQY-YAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVEFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRG---SGDTSNFD DYEEEEIRVS--ITEKCGKE-------------FCEF----------------------- ------------------------------------------------------------ ----- >M_mulatta_ENSMMUP00000018568 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNAAAA--KKGSEQ-------------E-------------------- --------------------------------------------S----VKEFLAK---A KEDFLKK---WESP--AQNTA-HLDQFERIKTLGTGSFGRVMLVKHKETGNH-YAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVGLPSI---------------- ------------------------------------------------------------ ------------------------------------------------------------ ----- >M_domestica_ENSMODP00000015141 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S----VKEFLAK---A KEEFLKK---WENP--SQPSVIQLDLYERLKTLGTGSFGRVVLVKSKETGNF-FAMKILD -KQKVVKLKQIEHTMNEKRI-L---QSISFPFLVKLECAFKDNSNLYMVMEYVAGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRYGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKCKG---PGDTSNFD DYEEEELRIS--ISEKCPKE-------------FAEF----------------------- ------------------------------------------------------------ ----- >M_mulatta_ENSMMUP00000026815 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNAAAK--KDTEQ--------------E-------------------- --------------------------------------------T----VNEFLAK---A RGDFLYR---WGNP--AQNTA-SSDQFERLKTLGTGSYGRVMLVRHRETGNH-YAMKILD -KQKVVRLKQVEHTLNEKRI-L---QAINFPFLVKLQFSFKDNSNLYLVMEYVPGGEMFS HLRRVGRF---SEPQACFYAAQVVLAFQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MTAGFPPFYADQP--IQIYEKIVSG--KVRFPSQ-LSPDLKDLLRSL L-QVDLTKRFGNLKNGVGDIKNHKWFATTNWIALFEKKVEAPFIPKYTG---PGDASNFD SYEEEEIRIS--VNEKCASK-------------FAEF----------------------- ------------------------------------------------------------ ----- >G_gorilla_ENSGGOP00000012966 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNAAAA--KKGSEQ-------------E-------------------- --------------------------------------------S----VKEFLAK---A KEDFLKK---WESP--AQNTA-HLDQFERIKTLGTGSFGRVMLVKHKETGNH-YAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGX AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRK---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----- >T_nigroviridis_ENSTNIP00000015136 V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------S-------------------- --------------------------------------------P----VKEFLAK---A KEDFLRK---WECP--QRCTT-GLDDFDRFKTLGTGSFGRVMLVKHKETNQF-YAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVSFPFLVRLVYAFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEQHARFYAAQIILTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVNDIKNHKWFSTTDWIAIYEKKVEAPFLPKCRG---PGDTSNFD DYEEEDVHIS--QTEKCAKE-------------FDDF----------------------- ------------------------------------------------------------ ----- >P_troglodytes_ENSPTRP00000035898 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNAPAK--KDTEQE-------------E-------------------- --------------------------------------------S----VNEFLAK---A RGDFLYR---WGNP--AQNTA-SSDQFERLRTLGMGSFGRVMLVRHRETGGH-YAMKILN -KQKVVKMKQVEHILNEKRI-L---QAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFS RLQRVGRF---SEPHACFYAAQVVLAFQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAVGFSPFYADQP--IQIYEKIVSG--RVRFPSK-LSSDLKDLLRSL L-QVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTG---PGDASNFD DYEEEELRIS--INEKCAKE-------------FSEF----------------------- ------------------------------------------------------------ ----- >P_pygmaeus_ENSPPYP00000021585 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNAPAK--KDTEQE-------------K-------------------- --------------------------------------------S----ATEFLVK---A RGDFLYR---WGNP--AQNTA-SSDQFERLRTLGTGSFGRVMLVRHRETGGH-YAMKILH -KQKLVKLKQVEHTLNEKRI-L---QAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFS HLRRVGSF---SEPHACFYAAQVVLAFQYLHSLDLIHRDLKPENLLIDQQGYLRVTDFGF AKR-----------------------V--KG-RTWTLCGTPQYLAPEIILSK-GYNKAVD WWALGVLIYE---MTVGFPPFYADEP--IQIYEKIVSG--RVRFPSK-LSSDLKDLLRSL L-QVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTG---PGDASNFD DYEEEELRIS--INEKCAKE-------------FSEF----------------------- ------------------------------------------------------------ ----- >H_sapiens_ENSP00000366488 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNAPAK--KDTEQE-------------E-------------------- --------------------------------------------S----VNEFLAK---A RGDFLYR---WGNP--AQNTA-SSDQFERLRTLGMGSFGRVMLVRHQETGGH-YAMKILN -KQKVVKMKQVEHILNEKRI-L---QAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFS RLQRVGRF---SEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAVGFPPFYADQP--IQIYEKIVSG--RVRFPSK-LSSDLKHLLRSL L-QVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTG---PGDASNFD DYEEEELRIS--INEKCAKE-------------FSEF----------------------- ------------------------------------------------------------ ----- >M_domestica_ENSMODP00000000650 MAARKE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LPCNQCTGTTTTLQKLE GFASRLFHRQPKGAAHDV--KTTLENESLHFSEYTALWDR-------------------- --------------------------------------------S----MRDFLSR---A KEDFLRK---WENP--TQNTA-ELSDFERKKTLGTGSFGRVMLVKHKATEQY-YAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVNFPFLVKLEYAFKDNSNLYMVMEYVPGGEMFS HLRKIGRF---SEPHARFYASQIVLTFEYLHALDLVYRDLKPENLLIDKYGYILVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MTAGYPPFFADQP--IQIYEKIISG--KVRFPSH-FSSELKDLLRNL L-QVDLTKRYGNLKNGVGDIKHHRWFSAIDWIAIFQRKVEAPFVPRYRG---AGDTSNFD DYEEEDIRVS--LTEKCAKE-------------FADF----------------------- ------------------------------------------------------------ ----- >A_aegypti_AAEL007293-PA M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNNATSTNKKVDAA-------------E-------------------- --------------------------------------------S----VKEFLDQ---A KEDFEEK---WKRN--PTNTA-ALDDFERIKTLGTGSFGRVMIVQHKSTKDY-YAMKILD -KQKVVKLKQVEHTLNEKRI-L---QAISFPFLVSLKFHFKDNSNLYMVLEYVPGGEMFS HLRKVGRF---SEPHSRFYAAQIVLAFEYLHYLDLIYRDLKPENLLIDSQGYLKVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLVYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FGSELKDLLRNL L-QVDLTKRYGNLKAGVNDIKGHRWFASTDWIAVFQKKIEAPFIPRCKG---PGDTSNFD DYEEEALRIS--STEKCAKE-------------FAEF----------------------- ------------------------------------------------------------ ----- >D_melanogaster_FBpp0079448 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNNATTSNKKVDAA-------------E-------------------- --------------------------------------------T----VKEFLEQ---A KEEFEDK---WRRN--PTNTA-ALDDFERIKTLGTGSFGRVMIVQHKPTKDY-YAMKILD -KQKVVKLKQVEHTLNEKRI-L---QAIQFPFLVSLRYHFKDNSNLYMVLEYVPGGEMFS HLRKVGRF---SEPHSRFYAAQIVLAFEYLHYLDLIYRDLKPENLLIDSQGYLKVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLVYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FGSDLKDLLRNL L-QVDLTKRYGNLKAGVNDIKNQKWFASTDWIAIFQKKIEAPFIPRCKG---PGDTSNFD DYEEEALRIS--STEKCAKE-------------FAEF----------------------- ------------------------------------------------------------ ----- >X_tropicalis_ENSXETP00000049427 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNAATA--KKGGEI-------------E-------------------- --------------------------------------------S----VKEFLAK---A KEDFLKK---WENP--AQNTA-HLEQFERIKTLGTGSFGRVMLVRHKENGSH-FAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVNFPFLVRLEYSFKDNSNLYMVMEYVAGGEMFS HLRRIGRF---SEPHARFYASQIVLTFEYLHALDLIYRDLKPENLLIDQQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVTDIKGHKWFSTTDWIAVYQKKV--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----- >D_rerio_ENSDARP00000023805 MAQPKD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PHFGHSSGTNSALQKLD TLASRFFYKCRKGNH-----DKGLENEGPHVSEHTVLWDT-------------------- --------------------------------------------A----MKETLAK---A KEDFLNK---WECQ--QKSTA-CLDDFDKLKTLGTGSFGRVMLVKHKQSEQY-FAMKILD -KLKVVKLKQIEHTLNEKKI-L---QAVSFPFLVKLECAFKDNSNLYMVMRYIQGGEMFS HLRRIGRF---SEQNARFYAAQIVLTFEYLHMLDLIYRDLKPENLLIDHQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRYPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVSDIKNHRWFASTDWIAIYEKKVDAPIIPKCRG---PGDTSNFD EYDEEVIRVS--VSEQCSKE-------------FLDF----------------------- ------------------------------------------------------------ ----- >C_intestinalis_ENSCINP00000024366 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------PWFGKKDNAHKS--PKQPKE-------------D-------------------- --------------------------------------------P----VKAFLAE---A KEEFLKK---WENP--IQNNS-KLDDFERLKTLGTGSFGRVILVKRKENSNY-YAMKILD -KQKVVKLKQVEHTLNEKKI-L---QAINFPFLVKMDFSFKDNSNLYMVLEYVIGGEMFS HLRRIGRF---SESHSRFYAAQIVLGFEYLHYLDIIYRDLKPENLLIDQQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FTSELKDLLRNL L-QVDLTKRFGNLKNGVSDIKGHRWFQPIDWIAVYQRKLDAPFIPKFKH---PGSTENFD DYEEEQLRVH--STEKCVKE-------------FADF----------------------- ------------------------------------------------------------ ----- >O_anatinus_ENSOANP00000010075 A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GGYLNP--AEPQEQ-------------S-------------------- --------------------------------------------P----VKEFLAK---A KEDFLRK---WENP--SQNTA-HLDQFERIKTLGTGSFGRVMLVKHKETGNH-FANPPPP LHAQVVKLKQIEHTLNEKRI-L---QAVHFPFLVCLEYSFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYMHSLDLIYRDLKPENLLIDQQGYLQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MVAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRYGNLKNGVSDIKNHKWFVTTDWIAIYQRKV--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----- >P_pygmaeus_ENSPPYP00000010802 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------ASNS-------------S-------------------- --------------------------------------------D----VKEFLAK---A KEDFLKK---WESP--AQNTA-HLDQFERIKTLGTGSFGRVMLVKHKETGNH-YAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFS HLRRIGRF----------------------------------------------VTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKG---PGDTSNFD DYEVE-IRVF--IIEKCGKE-------------FSEF----------------------- ------------------------------------------------------------ ----- >B_taurus_ENSBTAP00000046803 MAAYRE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VPCNQYTG-TTALQKLE GFASRLFHRHSKGTAHDQ--KTALENDSLHFSEHTALWDR-------------------- --------------------------------------------S----MKEFLAK---A KEDFLKK---WENP--APNNA-GLEDFERKKTLGTGSFGRVMLVKHKATEQY-YAMKILD -KQKVVKLKQIEHTLNEKRI-L---QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---RYPHTRFYSAIILLINEYLHLIHLLYKDLKVVTIVLDSRTYLQVPAFKQ MHR-----------------------V--KE-RKWLLTETPVFWPPEIILCK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRG---SGDTSNFD DYEEEDIRVS--VTEKCGKE-------------FCEF----------------------- ------------------------------------------------------------ ----- >C_familiaris_ENSCAFP00000030135 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QAH-YYMKVLN -SVQVVKLKQIEHTLNEKRI-L---QAVNFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRG---SGDTSNFD DYEEEDIRVS--ITEKCAKE-------------FCEF----------------------- ------------------------------------------------------------ ----- >C_elegans_ZK909.2c MEEEEWRRRLSAAIRREDEGSLEEDEEDEGFILHPLCRTGPLQMTVKASNSTTTLTPSST TTTSPSMPSSPSDSPSDDFSDDTNTS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --GVFPLTTALSFPVAPLSPRNTTSSITTGLVKKRRSSSSPEDICREKIPHILLKTSSGV VVPLASRGQRAPAITLQNPPPSAAIRTVPPPSFSTFSVRSLPFKTPNCGSKDDTDAENME GLDDDYLRQPTTSTSAPV---SPIDHRQVRRGGRGVVVES-------------------- --------------------------------------------Q----VPNFTAEIFWL KTQLSDH---WSMKWLFQNTA-CLDDFDRIKTLGTGSFGRVMLVKHKQSGNY-YAMKILD -KQKVVKLKQVEHTLNEKRI-L---QAIDFPFLVNMTFSFKDNSNLYMVLEFISGGEMFS HLRRIGRF---SEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDSTGYLKITDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVKFPSH-FSNELKDLLKNL L-QVDLTKRYGNLKNGVADIKNHKWFGSTDWIAIYQKKVSSYPI---------------- ------------------------------------------------------------ ------------------------------------------------------------ ----- >A_gambiae_AGAP001384-PA M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNNATSANKKVDAA-------------E-------------------- --------------------------------------------S----VREFLDQ---A KEDFEEK---WKRN--PTNTA-ALDDFERIKTLGTGSFGRVMIVQHKSTKDY-YAMKILD -KQKVVKLKQVEHTLNEKRI-L---QAISFPFLVSLKFHFKDNSNLYMVLEYVPGGEMFS HLRKVGRF---SEPHSRFYAAQIVL----------------------------------- --------------------------V--RG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLVYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FGSELKDLLRNL L-QVDLTKRYGNLKAGVNDIKGHRWFASTDWIAVFQKRIEAPFIPRCKG---PGDTSNFD DYEEETLRIS--STEKCAKE-------------FAEF----------------------- ------------------------------------------------------------ ----- >O_anatinus_ENSOANP00000022714 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------YLFNDNSNLYMVMEYVPGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRYGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKCRG---PGDTSNFD DYEEEDIRVS--LTEKCAKE-------------FADF----------------------- ------------------------------------------------------------ ----- >O_cuniculus_ENSOCUP00000011140 MAAYRE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LPCNQYTGTTTALQKLE GFASRLFHRHSKGTAHDQ--KTALENDSLHFSEHTALWDR-------------------- --------------------------------------------S----MKEFLAK---A KEDFLKK---WENP--PPXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXX -XXXVVKLKQIEHTLNEKRI-L---QAVNFPFLVRLEYSFKDNSNLYMVMESVTGGEMFS HLRRIGRF---SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQXXXXXX XXX-----------------------X--XX-XXXXXXXXXXXXXXXXXXXX-XXXK-VD WW-LGVLIYA---LAAGYPPFFADQP--LQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRG---SGDTSNFD DYEEEDIRVS--ITEKCAKE-------------FCEF----------------------- ------------------------------------------------------------ ----- >G_gorilla_ENSGGOP00000006581 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GNAPTK--KDTEQE-------------E-------------------- --------------------------------------------S----MNEFLAK---A RGDFLYR---WGNP--AQNTA-SSDQFERLRTLGMGSFGRVMLVRHRXTGGH-YAMKILN -KQKVVKMKQVEHILNEKRI-L---QAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFS RLQRVGRF---SXPHACFYAAQVVLAFQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAMGFPPFYADQP--IQIYEKIVSG--RVR----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >A_aegypti_AAEL001976-PA MPRWERWEQFKRQI---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------FTRRRYPKPTMSEPVVKSAATIKN LTPSAVKTSPLAVSGVRPAVKKFSHNSE-------------------------------- -------------------------------------------------YKQILNR---L KVDFEKK---YNNV-KASSGN-GLQDYDVLKTLGTGAFGVVKLIRRKNTEEY-FALKILS -KEKIVRHKQLQHTANEKRI-L---QSVEFPFLVNMECCFKDNSYIYLVMPFVCGGEMFA LLRKSKRF---GEEQAKFYGAQVALAIEYLHHMNLIYRDLKPENILIDMKGYVKITDFGF CKL-----------------------I--RD-RTWTLCGTPEYLAPEIIQSK-GYGKSVD WWSFGILLYE---MAAGYTPFYTNSSDHMVLFEKICKG--KFRFPAG-FGGDLKHLIQNI L-HADLTRRFGNLKNGANDIKQHIWFRGTNWIGLMNMEVSAPFIPKISG---PGDASQFD IYDEQDLKIA--SKCMFIKE-------------FADF----------------------- ------------------------------------------------------------ ----- >A_gambiae_AGAP008039-PA K----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DRMKQESSHKFSAGSD-------------------------------- -------------------------------------------------YHQTLSR---L KTEFEKR---YNDQ-KQASIA-SLTEYEILRTLGSGAFGTVKLIKRKASGEY-FAMKILS -KERIVYQKQLQHTTNEKRI-L---QSIRFPFVVNLEICYKDNSYLYLVMPFVNGGEMFT LLRHSRRF---SEAQAAFYGAQVALALEYLHGCNLIYRDLKPENLLVDYRGYVKMTDFGF CGKKMYLSIILGLVNANSNPSIAIKLI--KD-RTWTLCGTPEYLAPEIIQAK-GYGKSVD WWSYGVLLYE---MAAGYSPFYVNSSDQMVLFERICKG--KYKFPKS-FSTDLCSLVHHL L-QTDLSRRYGNLRNGCDDIKQHAWFKTINWYGLLNRELPAPYVPKLQG---PGDASLFD VYDEQKLKIAS------------------------------------------------- ------------------------------------------------------------ ----- >D_melanogaster_FBpp0075283 MDLWHIFLERILVACRVSASVFANFGCGLYSSWKLICGDHDSASGLRAGLATPTQRGKAT GDNGTTGTPARTIGKPQARIATAMSTATCARFCTPLSSGTAGSTSKL------------- ------------------------------------------------------------ ------------------------------------------------------------ --TTGNGSGNTMTSAYKIPSNNSTTANDSSNTETTFTFKLGRSNGRSSSNVASSESSDPL ESDYSEEDPEQE------------QQRPDPATNSRSSSTATTTTTSSADHDNDVDEEDEE DDENEGEGNGRDADDATHDSSESIEEDDGNETD------D-------------------- --------------------------------------------E----EDDDESE---E SS--------SVQTAKGVRKY-HLDDYQIIKTVGTGTFGRVCLCRDRISEKY-CAMKILA -MTEVIRLKQIEHVKNERNI-L---REIRHPFVISLEWSTKDDSNLYMIFDYVCGGELFT YLRNAGKF---TSQTSNFYAAEIVSALEYLHSLQIVYRDLKPENLLINRDGHLKITDFGF AKK-----------------------L--RD-RTWTLCGTPEYIAPEIIQSK-GHNKAVD WWALGVLIYE---MLVGYPPFYDEQP--FGIYEKILSG--KIEWERH-MDPIAKDLIKKL L-VNDRTKRLGNMKNGADDVKRHRWFKHLNWNDVYSKKLKPPILPDVHH---DGDTKNFD DYPEKDWKPAKAVDQRDLQY-------------FNDF----------------------- ------------------------------------------------------------ ----- >H_sapiens_ENSP00000262848 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MEAPGLAQAAAAESDSRKVAE------E-------------------- --------------------------------------------T----PDGAPAL---C PS----P---EALSPEP-PVY-SLQDFDTLATVGTGTFGRVHLVKEKTAKHF-FALKVMS -IPDVIRLKQEQHVHNEKSV-L---KEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFS YLRNRGRF---SSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGF AKK-----------------------L--VD-RTWTLCGTPEYLAPEVIQSK-GHGRAVD WWALGILIFE---MLSGFPPFFDDNP--FGIYQKILAG--KIDFPRH-LDFHVKDLIKKL L-VVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAG---DGDTSNFE TYPENDWDTAAPVPQKDLEI-------------FKNF----------------------- ------------------------------------------------------------ ----- >M_mulatta_ENSMMUP00000010893 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MEAPGLAEAAAAESDPRKVAE------E-------------------- --------------------------------------------T----PDGAPAL---C PS----P---EARSPEP-PAY-RLQDFDTLATVGTGTFGRVHLVKEKTAKHF-FALKVMS -IPDVIRLKQEQHVHNEKSV-L---KEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFS YLRNRGRF---SSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGF AKK-----------------------L--VD-RTWTLCGTPEYLAPEVIQSK-GHGRAVD WWALGILIFE---MLSGFPPFFDDNP--FGIYQKILAG--KIDFPRH-LDFHVKDLIKKL L-VVDRTRRLGNMKNGANDVKRHRWFHSVDWEAVPQRKLKPPIVPKIAG---DGDTSNFE TYPENDWDTAAPVPQKDLEI-------------FKNF----------------------- ------------------------------------------------------------ ----- >X_tropicalis_ENSXETP00000010923 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MEAAAAAVTVKARSGSRSAGKGSCDGGV-------------------- --------------------------------------------A----SPSSGCL---G LSGCGHT---SSPCPELQQQY-KLDDFDTVATVGTGTFGRVHLVKEKMGKQY-FALKVMS -IPDVIRLKQEQHVHNEKSV-L---KEVNHPFLVKLFWTSHDDRFLYMLMEYVPGGELFS YLRNMGRF---NNSTGLFYSTEIICAIEYLHSKEIVYRDLKPENILLDKEGHIKLTDFGF AKK-----------------------L--SD-RTWTLCGTPEYLAPEVIQSK-GHGRAVD WWALGILIFE---MLSGFPPFFDDNP--FGIYQKILAG--KIDFPRH-LDLYVKDLIKKL L-VVDRTRRLGNMKNGADDVKRHRWFRSIDWDTVPPRKLKPPIIPKVTH---EGDTSNFE AYPEDDWNKAPPVPPKDLEM-------------FNSF----------------------- ------------------------------------------------------------ ----- >A_aegypti_AAEL011837-PA MRHGLSIMLETFTD---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RSFVFLAFLITGTGTFGRVCLCRDKETDKY-WAMKILA -MADVIRLKQIEHVKNEKNI-L---REIDHPFVVNMRWHAKDDCCLYMLFEYVSGGELFS YLRNAGRF---DNATANFYACEIVLALEYLHALSIVYRDLKPENLLLDRDGHLKITDFGF AKK-----------------------L--KD-RTWTLCGTPEYLAPEIIQSK-GHNKAVD WWALGVLIYE---MVVGYPPFYDDNP--FGIYEKILSG--KIEWSRH-IEPIAKDLVKKL L-VQDRTKRLGNMKNGAEDIKRHRWFKHLDWDVVIRKQLKPPIVPKFVF---EGDTSNFD DYPETDWKSARSLDKVEMQL-------------FEDF----------------------- ------------------------------------------------------------ ----- >A_carolinensis_ENSACAP00000005623 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------AGY-RLEDLETLATVGTGTFGRVHLVKEKSAKTY-FALKVMS -IPDVIRLKQEQHVHNEKSV-L---KEVNHPFLIRLFWTYHDERFLYMLMEYVPGGELFS YLRNMGRF---NNSTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDKEGHIKLTDFGF AKK-----------------------L--VD-RTWTLCGTPEYLAPEVIQSK-GHGRAVD WWALGILIFE---MLSGFPPFFDDNP--FGIYQKILAG--KIDFPRH-LDLYVKDLIKKL L-VVDRTRRLGNMKNGADDVKRHRWFRSVDWDAVPQRKLKPPIVPKVSN---DGDTSNFE AYPEDDWNKTPPVPPKDLEI-------------FQNF----------------------- ------------------------------------------------------------ ----- >M_musculus_ENSMUSP00000045304 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------EPPAGAAATVKDP---DHDPVKTKVSAPAADP-------------------- --------------------------------------------K----PRTSSQK---- ------------------AGH-SLQDWDTIATVGTGTFGRVNLVKEKTGRQY-CALKIMS -IPDVIRLKQEQHVQNEKAV-L---KEINHPFLIKLLWTGHDNRFLYMLMEFVPGGELFT YLRNRGRF---SSVASVFYATEIVCAIEYLHSKEIVYRDLKPENILLDREGHIKLTDFGF AKK-----------------------L--VD-RTWTLCGTPEYLAPEVIQSK-GHGRAVD WWALGILIFE---MLSGFPPFFDDNP--FGIYQKILAC--KIDFPRQ-LDFTSKDLIKKL L-VVDRTRRLGNMKNGAEDIKRHRWFRGVEWESVPQRKLKPPIVPKLSG---DGDISNFE TYPESELDKTPSVSDKDLET-------------FKNF----------------------- ------------------------------------------------------------ ----- >T_guttata_ENSTGUP00000008885 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EP-AAY-KLEDLETLATVGTGTFGRVHLVKEKMSKHY-FALKVMS -IPDVIRLKQEQHVHNEKSV-L---KEVNHPFLIRLFWTNHDERFLYMLMEYVPGGELFS YLRNMGRF---NNSTGLFYSTEIICAIEYLHSKEIVYRDLKPENILLDKEGHIKLTDFGF AKK-----------------------L--VD-RTWTLCGTPEYLAPEVIQSK-GHGRAVD WWALGILIFE---MLSGFPPFFDDNP--FGIYQKILAG--KIDFPRH-LDLYVKDLIKKL L-VVDRTRRLGNMKNGADDVKRHRWFRSIDWDAVPQRRLKPPIVPKVSN---DGDTSNFE AYPEDDWNKTPPVPPKDLEI-------------FKNF----------------------- ------------------------------------------------------------ ----- >A_gambiae_AGAP011840-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TIGTGTFGRVCLCRDKITNKY-WAMKILA -MADVIRLKQIEHVKNEKNI-L---QEIDHPFIVNMRWNSKDDCCLYMLFEFVSGGELFS YLRNAGRF---DSATANFYACEIVLALEYLHSLSIVYRDLKPENLLLDREGHMKITDFGF AKK-----------------------L--KD-RTWTLCGTPEYLAPEIIQSK-GHNKAVD WWALGVLIYE---MIVGYPPFYDDNP--FGIYEKILSG--KIEWSRH-VDPIAKDLVKKL L-VLDRTKRLGNMKNGAEDVKRHRWFKHLDWNVVIRKQLKPPIVPTYVFSSKEDDTSNFD DYPETDWKSVRSLDKIEMQL-------------FEDF----------------------- ------------------------------------------------------------ ----- >C_familiaris_ENSCAFP00000016461 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TPGTGTFGRVQLVKDKAAKHF-FALKVMS -IPDVIRLKQEQHVHNEKSV-L---KEVSHPFLVKLFWTCHDERFLYMLMEFVPGGELFS YLRNRGRF---SSSTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDREGHIKLTDFGF AKK-----------------------L--VD-KTWTLCGTPEYLAPEVIQSK-GHGRAVD WWALGILIFE---MHSGFPPFFDDNP--FGIYQKILAG--KIDFPRH-LDFSVKDLIRKL L-VVDRTRRLGNMKNGADDVKRHRWFRTVDWEAVPQRKLKPPIVPKLCG---EGDTSNFE AYPENDWNTAPPVSPKDLEV-------------FKNF----------------------- ------------------------------------------------------------ ----- >P_troglodytes_ENSPTRP00000055043 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------ESNSREVAE------D-------------------- --------------------------------------------T----ADWAPAL---C PS----P---EARSPEA-PAY-RLQDFDALVTVGTGTFGRVHLVKEKTAKHF-FALKVMS -IPDVIRLKQEQHVHNEKSV-L---KEVSHPFLIRLFWTWHDEHFLYMLMEYVPGGELFS YLRNQGCF---SSTTGLFYSAEIICAMEYLHSKEIVYRDLEPENILLDRDGHIKLTDFGF AKK-----------------------L--VD-RTWTLCGTPEYLAPEVIQSK-GHGRAVD WWALGILIFE---MLSGFPPFFDENP--LGIYQKILAG--KLDFPRH-LDFRVKDLIKKL L-VVDRTRRLGNMKNGANDMKRHRWFRSVDWEAVPQRKLKPPIVPTTAG---DGDTSNFE TYPENDWDTAAPVPQKDLEI-------------FKNF----------------------- ------------------------------------------------------------ ----- >M_domestica_ENSMODP00000000005 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SSGSGDSEPA------------------------- -------------------------------------------------HSSSPAV---G PG----S---PAPSPEL-PAY-KLQDFDTLATVGTGTFGRVHLVKERTAKHY-FALKVMS -IPDVIRLKQEQHVHNEKSV-L---KEVSHPFLIRLYWTYHDERFLYMLMEYDPGEYLFS YVRDMGRF---NNSTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDKEGHIKLTDFGF AKK-----------------------L--LD-RTWTLCGTPEYLAPEVIQSK-GHGRAVD WWALGILIFE---MLSGFPPFFDDNP--FGIYQKILAG--KIDFPRH-LDLYVKDLIKKL L-VVDRTRRLGNMKNGADDVKKHRWFRSVDWDAVPQRKLKPPIVPKVSN---DGDTSNFE AYPEDDWNKMPPVPPKDLEI-------------FKNF----------------------- ------------------------------------------------------------ ----- >O_anatinus_ENSOANP00000006418 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------EQRPREVNVKF------------------------- -------------------------------------------------SKWMPCL---- ------DLCPLGICYSPHSTY-EKPNFSPLFFPGTGTFGRVHLVKERTAKHY-FALKVMS -IPDVIRLKQEQHVHNEKSV-L---KEVNHPFLIRLYWTYHDERFLYMLMEYVPGGELFS YLRNMGRF---NNSTGLFYSTEIICAIEYIHSKEIVYRDLKPENILLDKEGHIKLTDFGF AKK-----------------------L--VD-KTWTLCGTPEYLAPEVIQSK-GHGRAVD WWALGILIFE---MLSGFPPFFDDNP--FGIYQKILAG--KIDFPRH-LDLYVKDLIKKL L-VVDRTRRLGNMKNGADDVKRHRWFRSIDWEAVPQRKLKPPIVPKVSS---DGDTSNFE AYPEDDWNKTPPVPPKDMEI-------------FKNF----------------------- ------------------------------------------------------------ ----- >C_elegans_F47F2.1b M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VILSHHKRSPPLLMRLFRI CRFFRRLMSSSTSSVESVEDESCSNECSASFTFDTNNNSR-------------------- -------------------------------------------------GNNQVNE---L AEETHMK---LSIT-PTRESF-SLSQLERIITIGKGTFGRVELARDKITGAH-YALKVLN -IRRVVDMRQTQHVHNEKRV-L---LQLKHPFIVKMYASEKDSNHLYMIMEFVPGGEMFS YLRASRSF---SNSMARFYASEIVCALEYIHSLGIVYRDLKPENLMLSKEGHIKMADFGF AKE-----------------------L--RD-RTYTICGTPDYLAPESLART-GHNKGVD WWALGILIYE---MMVGKPPFRGKTT--SEIYDAIIEH--KLKFPRS-FNLAAKDLVKKL L-EVDRTQRIGCMKNGTQDVKDHKWFEKVNWDDTLHLRVEPPIVPTLYH---PGDTGNFD DYEEDTTG-GPLCSQRDRDL-------------FAEW----------------------- ------------------------------------------------------------ ----- >S_cerevisiae_YPL203W M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E FVAERAQPVGQTIQQQNVNT----YGQGVLQPHHDLQQRQ-------------------- --------------------------------------------Q----QQQQRQH---Q QLLTSQL---PQKSLVSKGKY-TLHDFQIMRTLGTGSFGRVHLVRSVHNGRY-YAIKVLK -KQQVVKMKQVEHTNDERRM-L---KLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFS LLRKSQRF---PNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGF AKE-----------------------V--QT-VTWTLCGTPDYIAPEVITTK-PYNKSVD WWSLGVLIYE---MLAGYTPFYDTTP--MKTYEKILQG--KVVYPPY-FHPDVVDLLSKL I-TADLTRRIGNLQSGSRDIKAHPWFSEVVWERLLAKDIETPYEPPITS--GIGDTSLFD QYPEEQLDYGIQGDDPYAEY-------------FQDF----------------------- ------------------------------------------------------------ ----- >R_norvegicus_ENSRNOP00000004920 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------EPPACAEAAVKDPAARDHDPVDAKISAPAADP-------------------- --------------------------------------------L----PRTSSQK---- ------------------EGH-SLQDWDTIATVGTGTFGRVNLVKEKTGRRY-CALKIMS -IPDVIRLKQEQHVQNEKAV-L---KEINHPFLIKLLWTDHDNRFLYMLMEFVPGGELFT YLRNRGRF---SSVAAIFYATEIVCAIEYLHSKEIVYRDLKPENILLDREGHIKLTDFGF AKK-----------------------L--VD-RTWTLCGTPEYLAPEVIQSK-GHGRAVD WWALGILIFE---MLSGFPPFFDDNP--FGIYQKILAC--KIDFPRQ-LDFTSKDLIKKL L-VVDRTRRLGNMKNGAEDIKRHRWFRGVEWESVPQRKLKPPIVPKLSS---DGDISNFE TYPEGELDKTPSVSDEDLET-------------FKNF----------------------- ------------------------------------------------------------ ----- >G_gallus_ENSGALP00000029643 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------TGTFGRVHLVKEKMGKHY-FALKVMS -IPDVIRLKQEQHVHNEKSV-L---KEVNHPFLIRLFWTYHDERFLYMLMEYVPGGELFS YLRNMGRF---NNSTGLFYSTEIICAIEYLHSKEIVYRDLKPENILLDKEGHIKLTDFGF AKK-----------------------L--VD-RTWTLCGTPEYLAPEVIQSK-GHGRAVD WWALGILIFE---MLSGFPPFFDDNP--FGIYQKILAG--KIDFPRH-LDLYVKDLIKKL L-VVDRTRRLGNMKNGADDVKRHRWFRSIDWDAVPQRRLKPPIVPKVSN---DGDTSNFE AYPEDDWNKMPPVPPKDLEI-------------FKNF----------------------- ------------------------------------------------------------ ----- >T_rubripes_ENSTRUP00000010892 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TLGTGTFGRVFLVKDKKTRTF-YALKQMK -IPDVIRLKQEQHVHNEKEV-L---TEVTHPFIIRLFWTHHDERFLYMLMDFVPGGELFS YLRSRGRF---SNATGLFYTSEIVCAIEYLHSKEIVYRDLKPENILLDSEGHIRLTDFGF AKK-----------------------L--SD-RTWTLCGTPEYLAPEVIQSK-GHGRAVD WWALGILIFE---MLAGYPPFFDDNP--FGIYQKILAG--KLEFPRH-LDFYVKDLIKKF L-VIDRARRLGNMKNGADDVKKHRWFKTIDWDAVPLRKLKPPIIPKVSH---EGDTSNFD VYPEEDWKKAPPVSHKDLEI-------------FENF----------------------- ------------------------------------------------------------ ----- >A_carolinensis_ENSACAP00000009669 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------YPQVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRFGNLKNGVNDIKNHKWFVTTDWIAIYQRKVEAPFIPKCKG---PGDTSNFD DYEEEEIRVS--ITEKCAKE-------------FAEF----------------------- ------------------------------------------------------------ ----- >B_taurus_ENSBTAP00000019102 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PHAGTGTFGRVQLVQEKTSKHF-FALKVMT -IPDIIRLKQEQHVHNEKSV-L---KEVNHPFLVKLFWTGHDDRFLYMLMEFVPGGELFS YLRNRGRF---SSNTGLFYAAEIVCAIEYLHSRDIVYRDLKPENILLDRDGHVKLTDFGF AKK-----------------------L--VD-KTWTLCGTPEYLAPEVIQSK-GHGRAVD WWALGILIFE---MLSGFPPFFDDNA--FGIYQKILAG--KIDFPRH-LEFSVKDLIRKL L-VTDRTRRLGNMKNGAEDVKQHRWFRVVDWGAVPERKLKPPIIPKLCS---EDDTSNFE AYPENDWTSAPPVSQKELDV-------------FKNF----------------------- ------------------------------------------------------------ ----- >O_latipes_ENSORLP00000025578 T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------GPEAMASSKAKAGVLGESGPLKEAKGAGGAPP-------------------- --------------------------------------------A----GEAAANS---- ------------------RSY-SLEELDTVATVGTGTFGRVFLVREQKSKAF-YALKQMK -IADVIRLKQEQHVHNEKEV-L---SEVNHPFLIRLLWTHHDERFLYMLMDFVAGGELFS YLRSRGRF---SNAAGLFYTSEIVCAIEYLHSKLIVYRDLKPENILLDAEGHIRLTDFGF AKK-----------------------L--SD-RTWTLCGTPEYLAPEVIQSK-GHGRAVD WWALGILVFE---MLAGYPPFFDDNP--FGIYQKILSG--KLDFPRH-LDFYVKDLIKKL L-VIDRARRLGNMKNGADDVKKHRWFKTVDWEAVPLRKLKPPINPKVSH---EGDTSNFD VYPEDDWKKDPAVPPKELEI-------------FKNF----------------------- ------------------------------------------------------------ ----- >D_rerio_ENSDARP00000080286 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------LGTGTFGRVFLVKDKKTRGF-FALKAMK -IPDVIRLKQEQHVHNEKEV-L---TEVNHPFLVRLFWTHHDDRFLYMLMEYVNGGELFS YLRSRGHF---SNSTGMFYSAEIVCAIEYLHSKEIVYRDLKPENILLDSEGHIRLTDFGF AKK-----------------------L--SE-RTWTLCGTPEYLAPEVIQSK-GHGRAVD WWALGVLIFE---MLAGYPPFFDDNP--FGIYQKILAG--KLEFPRH-LDLYVKDLIKKF L-VTDRERRLGNMKNGADDVKKHRWFKSVNWESVPCRKLKPPIVPKVSH---EGDTSNFD SYPDEEWKKDTPVPAKDLEI-------------FKNF----------------------- ------------------------------------------------------------ ----- >G_aculeatus_ENSGACP00000020058 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------GTGTFGRVFLVKDKKSRAF-YALKQMK -IPDVIRLKQEQHVHNEKEV-L---SEVNHPFLIRLFWTHHDERFLYMLMDYVAGGELFS FLRSRGRF---SNATGLFYTSEIVCAIEYLHSREVVYRDLKPENILLDSEGHIRLTDFGF AKK-----------------------L--SD-RTWTLCGTPEYLAPEVIQSK-GHGRAVD WWALGILVFE---MLAGYPPFFDDNP--FGIYQKILAG--KLEFPRH-LDFYVKDLIKKF L-VIDRARRLGNMKNGVDDVKKHRWFKTIDWDGVPLRKLKPPIVPKVSH---EGDTSNFD VYPEDDWKKDPPVPEKDLEI-------------FKNF----------------------- ------------------------------------------------------------ ----- >T_nigroviridis_ENSTNIP00000017513 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TSGTGTFGRV-LVKDKKTRTF-YALKQMK -IPDVIRLKQEQHVHNEKEV-L---TEVTHPFIIRLFWTHHDQRFLYMLMDFVPGGELFS YLRSRGRF---SNTTGLFYTSEIVCAIEYLHSKEIVYRDLKPENILLDSEGHIRLTDFGF AKK-----------------------L--SD-RTWTLCGTPEYLAPEVIQSK-GHGRAVD WWALGILIFE---MLAGYPPFFDDNP--FGIYQKILAG--KLEFPRH-LDFYVKDLIKKF L-VIDRARRLGNMKNGADDVKKHRWFKTVDWDAVPLRKLKPPIIPKVSH---EGDTSNFD VYPEDDWKKDPPVSPKDLEI-------------FENF----------------------- ------------------------------------------------------------ ----- >S_cerevisiae_YJL164C M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------STEEQNGGGQKSLD DRQGEESQKGETSERETTATESGNESKSVEKEGGETQEKP-------------------- --------------------------------------------K----QPHVTYY---N EEQYKQF---IAQARVTVGSI-VYKNFQILRTLGTGSFGRVHLIRSRHNGRY-YAMKVLK -KEIVVRLKQVEHTNDERLM-L---SIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFS LLRKSQRF---PNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGF AKY-----------------------V--PD-VTYTLCGTPDYIAPEVVSTK-PYNKSID WWSFGILIYE---MLAGYTPFYDSNT--MKTYEKILNA--ELRFPPF-FNEDVKDLLSRL I-TRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPPIQQ--GQGDTSQFD KYPEEDINYGVQGEDPYADL-------------FRDF----------------------- ------------------------------------------------------------ ----- >S_cerevisiae_YKL166C M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------YVDPMNNNEIRKLSITAKTETTPDNVGQ DIPVNAHSVHEECSSNTPVEINGRNSGKLKEEASAGICLV-------------------- --------------------------------------------K----KPMLQYR---- ---------------DTSGKY-SLSDFQILRTLGTGSFGRVHLIRSNHNGRF-YALKTLK -KHTIVKLKQVEHTNDERRM-L---SIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFS LLRKSQRF---PNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGF AKY-----------------------V--PD-VTYTLCGTPDYIAPEVVSTK-PYNKSVD WWSFGVLIYE---MLAGYTPFYNSNT--MKTYENILNA--ELKFPPF-FHPDAQDLLKKL I-TRDLSERLGNLQNGSEDVKNHPWFNEVIWEKLLARYIETPYEPPIQQ--GQGDTSQFD RYPEEEFNYGIQGEDPYMDL-------------MKEF----------------------- ------------------------------------------------------------ ----- >E_caballus_ENSECAP00000000007 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MS -IPDVIRLKQEQHVHNEKSV-L---KEVSHPFLVKLFWTYHDERFLYMLMEFVPGGELFS YLRNRGRF---ASNTGLFYSAEIVCAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGF AKK-----------------------L--VD-KTWTLCGTPEYLAPEVIQSK-GHGRAVD WWALGILIFE---MLSGFPPFFDDNP--FGIYQKILAG--KIDFPRH-LDFSVKDLVRKL L-VVDRTRRLGNMKNGADDVKRHRWFRTVDWEAVPQRKLKPPIVPKVCG---EGDTSNFE AYPENDWNTAPPVSPKDLEV-------------FKNF----------------------- ------------------------------------------------------------ ----- >D_melanogaster_FBpp0085090 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GPQPEQAQMHFSPKVD-------------------------------- -------------------------------------------------YILILDK---L REDFNKK---FATN-TPSPST-GLDDYEIKATLGSGSFGKVQLVRERESGVY-YASKQLS -KDQIVKTKQVSHVMSEKNV-L---RSMTFPNTVNLIASYKDFDSLYLVLPLIGGGELFT YHRKVRKF---TEKQARFYAAQVFLALEYLHHCSLLYRDLKPENIMMDKNGYLKVTDFGF AKK-----------------------V--ET-RTMTLCGTPEYLPPEIIQSK-PYGTSVD WWAFGVLVFE---FVAGHSPFSAHNRDVMSMYNKICEA--DYKMPSY-FSGALRHLVDHL L-QVDLSKRFGNLINGNRDIKEHEWFKDVEWIPLLNQTVNAPYVPNISN---PEDISNFD KVSDKPRPKA--KTMRHEEA-------------FADF----------------------- ------------------------------------------------------------ ----- >D_melanogaster_FBpp0085089 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SQHTSQYVFNSKED-------------------------------- -------------------------------------------------YNVILDN---M SREFEER---WNHQ-TQSPYT-NLENYITRAVLGNGSFGTVMLVREKSGKNY-YAAKMMS -KEDLVRLKQVAHVHNEKHV-L---NAARFPFLIYLVDSTKCFDYLYLILPLVNGGELFS YHRRVRKF---NEKHARFYAAQVALALEYMHKMHLMYRDLKPENILLDQRGYIKITDFGF TKR-----------------------V--DG-RTSTLCGTPEYLAPEIVQLR-PYNKSVD WWAFGILVYE---FVAGRSPFAIHNRDVILMYSKICIC--DYKMPSY-FTSQLRSLVESL M-QVDTSKRLGNSNDGSSDVKSHPWFQGVDWFGILNQEVTAPYQPTISG---AEDLSNFE NFEFKDRYKS--RINRHPEL-------------FANF----------------------- ------------------------------------------------------------ ----- >H_sapiens_ENSP00000264399 MGNGSVKPKHSKHPDGHSGNLTT--------------DALRNKVTELERELRRKDAEIQE REYHLKELREQLSKQTVAIAELTEELQNKCIQLNKLQDVVHMQGGSP--------LQASP DK-VPL--EVHRKTSGLVS-------LHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKAR V---RKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHI F-VLA--EGRLEVFQGEKLLSSIPMWTTFGELAILYNC-TRTASVKAITNVKTWALDREV FQNIMRRTAQAR-DEQYRNFLRS-VSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEE GSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKA--LIS--DDVRSANIIAEEN DVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHA--KRSMSNWKLSKA---L SLEMIQL---KEKVARFSSSS-PFQNLEIIATLGVGGFGRVELVKVKNENVA-FAMKCIR -KKHIVDTKQQEHVYSEKRI-L---EELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS ILRDRGSF---DEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGF AKK-----------------------IGSGQ-KTWTFCGTPEYVAPEVILNK-GHDFSVD FWSLGILVYE---LLTGNPPFSGVDQ--MMTYNLILKGIEKMDFPRK-ITRRPEDLIRRL C-RQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKG---PIDHSYFD KYPPEKGM-P---PDELSGW-------------DKDF----------------------- ------------------------------------------------------------ ----- >P_troglodytes_ENSPTRP00000027855 MGNGSVKPKHSKHPDGHSGNLTT--------------DALRNKVTELERELRRKDAEIQE REYHLKELREQLSKQTVAIAELTEELQNKCIQLNKLQDVVHMQGGSP--------LQASP DK-VPL--EVHRKTSGLVS-------LHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKAR V---RKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHI F-VLA--EGRLEVFQGEKLLSSIPMWTTFGELAILYNC-TRTASVKAITNVKTWALDREV FQNIMRRTAQAR-DEQYRNFLRS-VSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEE GSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKA--LIS--DDVRSANIIAEEN DVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHA--KRSMSNWKLSKA---L SLEMIQL---KEKVARFSSSS-PFQNLEIIATLGVGGFGRVELVKVKNENVA-FAMKCIR -KKHIVDTKQQEHVYSEKRI-L---EELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS ILRDRGSF---DEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGF AKK-----------------------IGSGQ-KTWTFCGTPEYVAPEVILNK-GHDFSVD FWSLGILVYE---LLTGNPPFSGVDQ--MMTYNLILKGIEKMDFPRK-ITRRPEDLIRRL C-RQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKG---PIDHSYFD KYPPEKGM-P---PDELSGW-------------DKDF----------------------- ------------------------------------------------------------ ----- >E_caballus_ENSECAP00000022043 MGNGSVKPKHSKHPDGHSGNLTT--------------DALQSKVTELERELRRKDAEIQE REYHLKELREQLSKQTVAIAELTEELQNKCIQLNKLQDVLHMQGGSP--------LQASP DK-VPL--EVHRKTSGLVS-------LHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKAR V---RKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHI F-VLA--EGQLEVFQGEKLLSSIPMWTTFGELAILYNC-TRTASVKAITNVKTWALDREV FQNIMRRTAQAR-DEQYRNFLRS-VSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEE GSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKA--LIS--EDVRSANIIAEEN DVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHA--KRSMSNWKLSKA---L SLEMIQL---KEKVARFSSSS-PFQNLEIIATLGVGGFGRVELVKVKNENVA-FAMKCIR -KKHIVDTKQQEHVYSEKRI-L---EELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS ILRDRGSF---DEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGF AKK-----------------------IGSGQ-KTWTFCGTPEYVAPEVILNK-GHDFSVD FWSLGILVYE---LLTGNPPFSGIDQ--MMTYNLILKGIEKMDFPRK-ITRRPEDLIRRL C-RQNPTERLGNLKNGINDIKRHRWLNGFNWEGLKARNLPSPLQRELSG---PTDHSYFD KYPPEKGV-P---PDELSGW-------------DKDF----------------------- ------------------------------------------------------------ ----- >O_anatinus_ENSOANP00000011192 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LVNVKLWAIDRQC FQTIMMRTGLIK-HTEYMEFLKS-VPTFQSLPEEILSKLADVLEELHRENGYFRLRKASL KGTSKMGSECSPSVSQNESILSFHVWTSSLEAHFKFSFLLCFLCR--EDVRTANVIAAE- AVTCLVIDRDSFKHLIGGLDD--------VSNKAYED----------------------- -AEAKAK---YEAEAAFFANL-KLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILK -KRHIVDTRQQEHIRSEKQI-M---QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWT ILRDRGSF---EDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGF AKK-----------------------IGFGK-KTWTFCGTPEYVAPEIILNK-GHDISAD YWSLGILMYE---LLTGSPPFSGPDP--MKTYNIILRGIDMIEFPKK-IAKNAANLIKKL C-RDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVAS---PTDTSNFD SFPEDNDEPP---PDDNSGW-------------DIDF----------------------- ------------------------------------------------------------ ----- >H_sapiens_ENSP00000363092 MGT----------------------------------------LRDLQYALQEKIEELRQ RDALIDELELELDQKDELIQKLQNELDKYRSVIRPATQ---QAQKQS------------- ----------------------ASTLQGEPRTKRQAISAEPTAFDIQDLSHVTLPFY--- ----PKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLV Y-VME--DGKVEVTKEGVKLCTMGPGKVFGELAILYNC-TRTATVKTLVNVKLWAIDRQC FQTIMMRTGLIK-HTEYMEFLKS-VPTFQSLPEEILSKLADVLEETHYENGEYIIRQGAR GDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKA--LQG--EDVRTANVIAAE- AVTCLVIDRDSFKHLIGGLDD--------VSNKAYED----------------------- -AEAKAK---YEAEAAFFANL-KLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILK -KRHIVDTRQQEHIRSEKQI-M---QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWT ILRDRGSF---EDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGF AKK-----------------------IGFGK-KTWTFCGTPEYVAPEIILNK-GHDISAD YWSLGILMYE---LLTGSPPFSGPDP--MKTYNIILRGIDMIEFPKK-IAKNAANLIKKL C-RDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVAS---PTDTSNFD SFPEDNDEPP---PDDNSGW-------------DIDF----------------------- ------------------------------------------------------------ ----- >M_musculus_ENSMUSP00000073268 MGT----------------------------------------LRDLQYALQEKIEELRQ RDALIDELELELDQKDELIQKLQNELDKYRSVIRPATQ---QAQKQS------------- ----------------------ASTLQGEPRTKRQAISAEPTAFDIQDLSHVTLPFY--- ----PKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLV Y-VME--DGKVEVTKEGVKLCTMGPGKVFGELAILYNC-TRTATVKTLVNVKLWAIDRQC FQTIMMRTGLIK-HTEYMEFLKS-VPTFQSLPDEILSKLADVLEETHYENGEYIIRQGAR GDTFFIISKGQVNVTREDSPSEDPVFLRTLGKGDWFGEKA--LQG--EDVRTANVIAAE- AVTCLVIDRDSFKHLIGGLDD--------VSNKAYED----------------------- -AEAKAK---YEAEAAFFANL-KLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILK -KRHIVDTRQQEHIRSEKQI-M---QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWT ILRDRGSF---EDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGF AKK-----------------------IGFGK-KTWTFCGTPEYVAPEIILNK-GHDISAD YWSLGILMYE---LLTGSPPFSGPDP--MKTYNIILRGIDMIEFPKK-IAKNAANLIKKL C-RDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVAS---PTDTSNFD SFPEDSDEPP---PDDNSGW-------------DIDF----------------------- ------------------------------------------------------------ ----- >P_troglodytes_ENSPTRP00000004326 MGT----------------------------------------LRDLQYALQEKIEELRQ RDALIDELELELDQKDELIQKLQNELDKYRSVIRPATQ---QAQKQS------------- ----------------------ASTLQGEPRTKRQAISAEPTAFDIQDLSHVTLPFY--- ----PKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLV Y-VME--DGKVEVTKEGVKLCTMGPGKVFGELAILYNC-TRTATVKTLVNVKLWAIDRQC FQTIMMRTGLIK-HTEYMEFLKS-VPTFQSLPEEILSKLADVLEETHYENGEYIIRQGAR GDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKA--LQG--EDVRTANVIAAE- AVTCLVIDRDSFKHLIGGLDD--------VSNKAYED----------------------- -AEAKAK---YEAEAAFFANL-KLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILK -KRHIVDTRQQEHIRSEKQI-M---QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWT ILRDRGSF---EDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGF AKK-----------------------IGFGK-KTWTFCGTPEYVAPEIILNK-GHDISAD YWSLGILMYE---LLTGSPPFSGPDP--MKTYNIILRGIDMIEFPKK-IAKNAANLIKKL C-RDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVAS---PTDTSNFD SFPEDNDEPP---PDDNSGW-------------DIDF----------------------- ------------------------------------------------------------ ----- >B_taurus_ENSBTAP00000024490 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LYR--EDVRTANVIAAE- AVTCLVIDRDSFKHLIGGLDD--------VSNKAYED----------------------- -AEAKAK---YEAEAAFFANL-KLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILK -KRHIVDTRQQEHIRSEKQI-M---QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWT ILRDRGSF---EDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGF AKK-----------------------IGFGK-KTWTFCGTPEYVAPEIILNK-GHDISAD YWSLGILMYE---LLTGSPPFSGPDP--MKTYNIILRGIDMIEFPKK-IAKNAANLIKKL C-RDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVAS---PTDTSNFD SFPEDNDEPP---PDDNSGW-------------DIDF----------------------- ------------------------------------------------------------ ----- >G_gallus_ENSGALP00000006027 LGT----------------------------------------LRDLQYALQEKIEELRQ RDALIDELELELDQKDDLIPKLQNKL-VYRSVIRPAAR---QAQQQS------------- ----------------------ARSLQGEQRTKRQAISAEPTAFDIQDLSHVTLPFY--- ----PKSPQSKELIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLV Y-VME--DGKVEVTKEGVKLCTMGPGKVFGELAILYNC-TRTATVKTLVNVKLWAIDRQC FQTIMMRTGLIK-HTEYMEFLKS-VPTFQSLPEEILSKLADVLEETHYESGEYIIRQGAR GDTFFIISKGKVNVTREDSPSEDPVFLRTLGKGDWFGEKA--LQW--EDVRTANVIAAE- AVTCLVIDRDSFKHLIGGLDD--------VSNKAYED----------------------- -AEAKAK---YEAEAAFFANL-KLSDFNIIDTLGVGGFGRVELVQLKSEETKTFAMKILK -KRHIVDTRQQEHIRSEKQI-M---QSAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWT ILRDRGSF---EDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGF AKK-----------------------IGFGK-KTWTFCGTPEYVAPEIILNK-GHDISAD YWSLGILMYE---LLTGSPPFSGPDP--MKTYNIILRGIDMIEFPKK-IAKNAANLIKKL C-RDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVAS---PTDTSNFD SFPEDNDEPP---PDDNSGW-------------DIDF----------------------- ------------------------------------------------------------ ----- >C_familiaris_ENSCAFP00000013072 MGNGSVKPKHPKHPDGHPGNLST--------------HALRSKVVELERELRRKEAEIQE REYHLKELREQLSRQTAAVAELTEELQNKCIQLNKLQDVVHLQGGSL--------PQASP DK-VPL--EVHRKASGLVS-------LHSRRGAKAGVSAEPTSRTYDLNKPPEFSFEKAR V---RKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHI F-VLAVIEGRLEVFQGEKLLSSIPLWTTFGELAILYNC-TRTASVKALTNVKTWALDREV FQNIMRRTAQAR-DEQYRNFLRS-VSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEE GSTFFILAKGKVKVTQSTEGHDQPQVIKTLQKGEYFGEKA--LIS--EDVRSANIIAEEN DVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHA--KRSMSNWKLSKA---L SLEMIQL---KEKVARFSSSS-PFQNLEIIATLGVGGFGRVELVKVKNENVA-FAMKCIR -KKHIVDTKQQEHVYSEKRI-L---EELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS ILRDRGSF---DEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDADGYLKLVDFGF AKK-----------------------IGSGQ-KTWTFCGTPEYVAPEVILNK-GHDFSVD FWSLGILVYE---LLTGNPPFSGIDQ--MMTYNLILKGIEKMDFPRK-ITRRPEDLIRRL C-RQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARNLPSPLQRELSG---PTDHSYFD KYPPEKGV-P---PDELSGW-------------DKDF----------------------- ------------------------------------------------------------ ----- >P_pygmaeus_ENSPPYP00000016617 MGNGSVKPKHSKHPDGHSGNLTT--------------DALRNKVTELERELRRKDAEIQE REYHLKELREQLSKQTVAIAELTEELQNKCIQLNKLQDVVHMQGGSL--------LQASP DK-VPL--EVHRKTSGLVS-------LHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKAR V---RKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHI F-VLA--EGRLEVFQGEKLLSSIPMWTTFGELAILYNC-TRTASVKAITNVKTWALDREV FQNIMRRTAQAR-DEQYRNFLRS-VSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEE GSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKA--LIS--DDVRSANIIAEEN DVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHA--KRSMSNWKLSKA---L SLEMIQL---KEKVARFSSSS-PFQNLEIIATLGVGGFGRVELVKVKNENVA-FAMKCIR -KKHIVDTKQQEHVYSEKRI-L---EELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS ILRDRGSF---DEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGF AKK-----------------------IGSGQ-KTWTFCGTPEYVAPEVILNK-GHDFSVD FWSLGILVYE---LLTGNPPFSGVDQ--MMTYNLILKGIEKMDFPRK-ITRRPEDLIRRL C-RQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELNG---PIDHSYFD KYPPEKGM-P---PDELSGW-------------DKDF----------------------- ------------------------------------------------------------ ----- >M_mulatta_ENSMMUP00000026112 MGNGSVKPKHSKHPDGHSGNLTT--------------DALRNKVTELERELRRKDAEIQE REYNLKELREQLSKQTVAIAELTEELQNKCIQLNKLQDVVHMQGGSP--------LQASP DK-VPL--EVHRKTSGLVS-------LHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKAR V---RKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHI F-VLA--EGRLEVFQGEKLLSSIPMWTTFGELAILYNC-TRTASVKAITNVKTWALDREV FQNIMRRTAQAR-DEQYRNFLRS-VSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEE GSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKA--LIS--DDVRSANIIAEEN DVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHA--KRSMSNWKLSKA---L SLEMIQL---KEKVARFSSSS-PFQNLEIIATLGVGGFGRVELVKVKNENVA-FAMKCIR -KKHIVDTKQQEHVYSEKRI-L---EELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS ILRDRGSF---DEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGF AKK-----------------------IGSGQ-KTWTFCGTPEYVAPEVILNK-GHDFSVD FWSLGILVYE---LLTGNPPFSGIDQ--MMTYNLILKGIEKMDFPRK-ITRRPEDLIRRL C-RQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELNG---PIDHSYFD KYPPEKGM-P---PDELSGW-------------DKDF----------------------- ------------------------------------------------------------ ----- >M_musculus_ENSMUSP00000031277 MGNGSVKPKHAKHPDGHSGNLSN--------------EALRSKVLELERELRRKDAELQE REYHLKELREQLAKQTVAIAELTEELQSKCIQLNKLQDVIHVQGGSP--------LQASP DK-VPL--DVHRKTSGLVS-------LHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKAR V---RKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYVIKQGEPGNHI F-VLA--EGRLEVFQGEKLLSSIPMWTTFGELAILYNC-TRTASVKAITNVKTWALDREV FQNIMRRTAQAR-DEEYRNFLRS-VSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEE GSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKA--LIS--DDVRSANIIAEEN DVACLVIDRETFNQTVGTFDELQKYLEGYVATLNRDDEKRHA--KRSMSSWKLSKA---L SLEMIQL---KEKVARFSSTS-PFQNLEIIATLGVGGFGRVELVKVKNENVA-FAMKCIR -KKHIVDTKQQEHVYSEKRI-L---EELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS ILRDRGSF---DEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDADGYLKLVDFGF AKK-----------------------IGSGQ-KTWTFCGTPEYVAPEVILNK-GHDFSVD FWSLGILVYE---LLTGNPPFSGIDQ--MMTYNLILKGIEKMDFPRK-ITRRPEDLIRRL C-RQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLRRELSG---PIDHSYFD KYPPEKGV-P---PDEMSGW-------------DKDF----------------------- ------------------------------------------------------------ ----- >R_norvegicus_ENSRNOP00000003237 MGNGSVKPKHSKHPDGQSGNLSN--------------EALRSKVAELEREVKRKDAELQE REYHLKELREQLAKQTVAIAELTEELQSKCIQLNKLQDVIHVQGGSP--------LQASP DK-VPL--DVHRKTSGLVS-------LHSRRGAKAGVSAEPTSRTYDLNKPPEFSFEKAR V---RKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIVKQGEPGNHI F-VLA--EGRLEVFQGEKLLSSIPMWTTFGELAILYNC-TRTASVKAITNVKTWALDREV FQNIMRRTAQAR-DEEYRNFLRS-VSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEE GSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKA--LIS--DDVRSANIIAEEN DVACLVIDRETFNQTVGTFDELQKYLEGYVATLNRDDEKRHA--KRSMSSWKLSKA---L SLEMIQL---KEKVARFSSTS-PFQNLEIIATLGVGGFGRVELVKVKNENIA-FAMKCIR -KKHIVDTKQQEHVYSEKRI-L---EELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS ILRDRGSF---DEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDADGYLKLVDFGF AKK-----------------------IGSGQ-KTWTFCGTPEYVAPEVILNK-GHDFSVD FWSLGILVYE---LLTGNPPFSGIDQ--MMTYNLILKGIEKMDFPRK-ITRRPEDLIRRL C-RQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLRRELSG---PIDHSYFD KYPPEKGV-P---PDEMSGW-------------DKDF----------------------- ------------------------------------------------------------ ----- >B_taurus_ENSBTAP00000003877 MGNGSVKPKHSKNPDGHPGNLTA--------------SALRSRVTELERELRRKDAEIQE REYHLKELREQLSKQTVAIAELTEELQNKCIQLNKLQDVVHLQGGSL--------PRASP DK-VPL--EVQRKTSGLVS-------LHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKAR V---RKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHI F-VLA--EGRLEVSQGEKLLSSIPMWTTFGELAILYNC-TRTASVKAITNVKTWALDREV FQNIMRRTAQAR-DEQYRNFLRS-VSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEE GSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKA--LIS--EDVRSANIIAEEN DVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHA--KRSMSSWKLSKA---L SLEMIQL---KEKVARFSSSS-PFQNLEIIATLGVGGFGRVELVKVKNENVA-FAMKCIR -KKHIVDTKQQEHVYSEKKI-L---EELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS ILRDRGSF---DEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGF AKK-----------------------IGSGQ-KTWTFCGTPEYVAPEVILNK-GHDFSVD FWSLGILVYE---LLTGNPPFSGIDQ--MMTYNLILKGIEKMDFPRK-ITRRPEDLIRRL C-RQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARNLPSPLQRELSG---PTDHSYFD KYPPERGV-P---PDELSGW-------------DKDF----------------------- ------------------------------------------------------------ ----- >T_guttata_ENSTGUP00000016783 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------QTHYENGEYIIRQGAR GDTFFIISKGKVNVTREDSPSEDPVFLRTLGKGDWFGEKA--LQG--EDVRTANVIAAE- AVTCLVIDRDSFKHLIGGLDD--------VSNKAYED----------------------- -AEAKAK---YEAEAAFFANL-KLSDFNIIDTLGVGGFGRVELVQLKSEEAKTFAMKILK -KRHIVDTRQQEHIRSEKQI-M---QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWT ILRDRGSF---EDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGF AKK-----------------------IGFGK-KTWTFCGTPEYVAPEIILNK-GHDISAD YWSLGILMYE---LLTGSPPFSGPDP--MKTYNIILRGIDMIEFPKK-IAKNAANLIKKL C-RDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVAS---PTDTSNFD SFPEDSDEPP---PDDNSGW-------------DIDF----------------------- ------------------------------------------------------------ ----- >O_latipes_ENSORLP00000022254 MGNASIRSKCCKSTEGSVSTSTK-----DQQAKQPTRDSLRVRVEELEREVKLKDEELGA REQHIKALQEQLAKQTQVLSELSEELHAKSITLNMLQDAMRSEPSTG--------LAFRP AS---V--RASGKSSPNLSVR-TKDTPNRRKGAKSGVSAEPT-----SSSLQKFSFEKAR V---PKDARNLALVSCALVQTKKLKKINSEMLKVNLEGLYGRIYTARFKILPGGGPGE-- --LLV--ERQLSVACGTARLEGLKECSVISQLANGFECREETDMIGAIGSFPSWRPSINE FQVILSQTASLETREKYKSFSKV-LKILPSLLSVEGVWLLTCSLLEYYDKGEYIIREGEE GSTFYIIAQGKVKVTQTTEAHKLPQIINALQKGDYFGEKA--LVS--DDVRSANIIADDN GVECLVIDRETFDQTVGNFNELQKHLQGYVASLDRDDKKRHL--K-KSVSRHQSQS---L SPGFMQL---KDMVSLFTSSR-PFHHLEVIATLGVGGFGRVELVKVKGEDVT-FALKAIK -KKHVVENKQEEHIHSERRI-L---AEARSPFIVRLYRTFKDSKYVYMLLEACLGGEVWS LLRDRGSF---DDPTAKFCIGCVTEAFEYLHRKGVLYRDLKPENLLLDMEGYVKLVDFGF AKK-----------------------IRSGQ-KTWTFCGTPEYVAPEIILNK-GHNFSVD FWALGILVFE---LLTGSPPFSGSDQ--MTIYTFILKGIEKMDFPKM-ISKRPEDLIRKL C-RRNPSERLGNLKNGITDIKKHRWFTGFNWEGLKARTLASPLKRELKG---PMDHSYFD SYPPDEDS-P---PDELSGW-------------DEDF----------------------- ------------------------------------------------------------ ----- >G_gallus_ENSGALP00000017721 MGNASMKHKHLRQPDRHVANLAL--------------GCASHRVLELEKELKRKDEELQE GQSLVAELQEQLSVQTKVIAELTKELQSKCIQLNKLQDVINTQGEHS--------LQPSP FR---------VTPKNQIS-------ADRRKGAKEGVSAEPTTQLYDSSKQARFSFEKSR V---RKDSSEKKLITDALNKNQFLKRLEPQQIREMVECMYERTFQQGSYVIRQGEPGNHI F-VLK--EGRLEVFQQNKLLSSIPVWTAFGELAILYNC-TRTASVKAITNVKTWALDREV FQNIMRVTAQTR-QEQYRNFLRS-VSLLKNLPEDKLTKIMDCLEVEYYNKGDYVIREGEE GNTFFIIAKGKVKVTQSTADHSQPQLIKNLHKGDYFGEKA--LIS--DDVRSANVIADEY DVECLVIDRDTFNQTVGTYEELQTYLEGYVANLARADEKRHA--KRRSFCGQSTKE---V SLEMIQL---KEKVAQF-PSS-PFQNLEVVTTLGVGGFGRVELVKVKNENVA-FAMKCIK -KKHVVDTKQQEHIYSEKKI-L---EQICSPFIVKLYRTFKDSKYVYMLLEACLGGELWS LLRDRGCF---DEPTTKFCVGCVTEALDYLHHIGIVYRDLKPENLILDAEGYIKLVDFGF AKK-----------------------IGSGQ-KTWTFCGTPEYVAPEVILSK-GHDFSVD FWSLGILVYE---LLTGSPPFSGADQ--MTTYNLILKGIEKLDFPRT-ITRRPEDLIRRL C-RQNPTERLGNLRNGINDIKKHRWLNGFNWDGLKLRKLASPLKRELSG---PTDYSYFD SYPPEEGM-P---PDELSGW-------------DKDF----------------------- ------------------------------------------------------------ ----- >T_guttata_ENSTGUP00000002960 MGNRLVKPKHLRQPNRHMANLAI------------GSDVLCSKVLELEKELKRKDQQLQE SQHHVAELQEQLAMQTKVIAELSNELQSKCIQLNKLQDVISTQGEHS--------LQPSP FK---------------VS-------ADRRRGAKEGVSAEPTTALCDLSRQTMFSLEKAT V---QKDSSEKKLITDALNRNQFLKRLEPHQTRDMVECMYERTFQQGSYVIRQGEPGNHI F-VLK--EGSLEVFQQNKLLSSIPVWTAFGELAILYNC-TRTASVKAITNVKTWALDREV FQNIMRVTAQTR-QEQYRKFLRS-VSLLKNLPEDKLTKIMDCLEVEYYDKGDYVIREGEE GNTFFIIAKGKVIVTQSTTDHSQPQVIKNLHKGDYFGEKA--LIS--DDTRSANVIADEY NVECLVIDRETFNQTVGTYEELQTYLEGYVANLAQADEKRHA--KGRSFCGQLTKE---V SLEMIEL---KEKVAQF-PPS-PFQNLEVVTTLGVGGFGRVELVKVKNENMA-FAMKCIK -KKHVVDTKQQEHIYSEKKI-L---EQICSPFVVKLYRTFKDNKYVYMLLEACLGGELWS LLRDRGSF---DEFTTKFCVGCVTEAFDYLHQIGIIYRDLKPENLILDAEGYIKLVDFGF AKK-----------------------IGSGQ-KTWTFCGTPEYVAPEVILSK-GHDFSVD FWSLGILVYE---LLTGSPPFSGADQ--MMTYNLILKGIEKLDFPKV-ITRRPEDLIRRL C-RQNPTERLGNLRNGINDIKKHRWLSGFNWDSLKVRKLTSPLKRELSG---PTDYSYFD SYPPEVGS-P---PDELSGW-------------DKDF----------------------- ------------------------------------------------------------ ----- >E_caballus_ENSECAP00000011730 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MEFLKS-VPTFQSLPEEILSKLADVLEETHYENGEYIIRQGAR GDTFFIISKGKVNVTREDSPSEDPVFLRTLGKGDWFGEKA--LQG--EDVRTANVIAAE- AVTCLVIDRDSFKHLIGGLDD--------VSNKAYED----------------------- -AEAKAK---YEAEAAFFANL-KLSDFNVIDTLGVGGFGRVELVQLKSEESKTFAMKILK -KYHIVNTRQQEHIRSEKQI-M---QGAHSDFIVRLYRTFKDSKYLYMLMEVCLGGELWT ILRDRGSF---EDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYTKLVDFGF AKK-----------------------IGFGK-KTWTFCGTPEYVAPEIILNK-GHDISAD YWSLGILMYE---LLTGSPPFSGPDP--MKTYNIILRGIDMIEFPKK-IAKNAANLIKKL C-RDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVAS---PTDTSNFD SFPEDNDEPP---PDDNSGW-------------DIDF----------------------- ------------------------------------------------------------ ----- >T_nigroviridis_ENSTNIP00000021534 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TVTPEHRRLTYAKMKRIVTYFSALLKEK-------------------- --KVGFSDFLHKF----------------LSGQQLFQHTLPAEMHA---CGFIQHS---D LKDLFTVNKPGTMSYRWFTRM-KPSDFDYLKVIGKGSFGKVLLAKHREQGRY-YAVKVLQ -KQTIVKRKEQKHVMVERSVLL---KGLQHPFLVGLHFSFQSANLLYFVLDYVNGGELFY HLQREGSF---PEPRAGFYAAEMALALGYLHSLAIVYRDLKPENILLDSQGHVVLADFGL CKEG----------------------VAVGG-VMHTFCGTPEYLAPEVLNGG-PYSPVVD WWGLGVVLYE---MLFGLPPFYSQSK--AQMFENILHG--SLRLHGR-ASPAAQSLLRGL L-ERCVSKRVGG-SRDLAELQEHSFFAPIDWDDLLARKLRPPFIPSVTG---PCDISYID PEFTLQPV-PDSVMETCPVG--------PASEAFPGFSFMNPAEYVAS------------ ------------------------------------------------------------ ----- >A_carolinensis_ENSACAP00000005444 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------S-VPTFQSLPEEILSKLADVLEETHYENGEYIIRQGAR GDTFFIISKGKVNVTREDLPGEEPIFLRTLGKGDWFGEKA--LQG--EDVRTANVIAAE- AVMCLVIDRDSFKHLIGGLDD--------VSNKAYED----------------------- -AEAKAK---YEAEAAFFANL-KLSDFNIIDTLGVGGFGRVELVQLKSDEAKTFAMKILK -KRHIVDTRQQEHIRSEKQI-M---QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWT ILRDRGSF---EDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGF AKK-----------------------IGFGK-KTWTFCGTPEYVAPEIILNK-GHDISAD YWSLGILMYE---LLTGSPPFSGPDP--MKTYNIILRGIDMIEFPKK-IAKNAANLIKKL C-RDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIVPSVAS---PTDTSNFD SFPEDNDEPP---PDDNSGW-------------DIDF----------------------- ------------------------------------------------------------ ----- >C_elegans_W10G6.2b M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GSMYYNESRMVRKDEVTCNVIIGDDKKTVVY ALRIGNGPIMQKTFEEYERFFTTEKDMIPATIFTAPKKKF-------------------- ------------LQADSKFYEKRRVWILVISQHLVDNNLRSED-VRRFFHLESPDD---D ENNVDLGPSER-------KTA-TANDFDYLTTIGKGSFGRVYQVRHKETKKI-YAMKILS -KEHIRKKNEVKHVMAERNVLI---NNFKHPFLVSLHFSFQNKEKLYFVLDHLNGGELFS HLQREKHF---SESRSRFYAAEIACALGYLHEKNIIYRDLKPENLLLDDKGYLVLTDFGL CKED----------------------MQGSK-TTSTFCGTPEYLAPEIILKK-PYDKTVD WWCLGSVLYE---MIFGLPPFYSKDH--NEMYDKIINQ--PLRLKHN-ISVPCSELITGL L-QKDRSKRLGH-RNDFRDIRDHPFFLPVDWDKLLNRELKAPFIPKVKN---AMDTSNIS KEFVEIQIDPSSLAPQQLAV-------THRDHDFENFTFVDTNRVLV------------- ------------------------------------------------------------ ----- >M_mulatta_ENSMMUP00000014212 MGT----------------------------------------LRDLQYALQEKIEELRQ RDALIDELELELDQKDELIQKLQNELDKYRSVIRPATQ---QAQKQS------------- ----------------------ASTLQGEPRTKRQAISAEPTAFDIQDLSHVTLPFY--- ----PKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLV Y-VME--DGKVEVTKEGVKLCTMGPGKVFGELAILYNC-TRTATVKTLVNVKLWAIDRQC FQTIMMRTGLIK-HTEYMEFLKS-VPTFQSLPEEILSKLADVLEETHYENGEYIIRQGAR GDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKA--LQG--EDVRTANVIAAE- AVTCLVIDRDSFKHLIGGLDD--------VSNKAYED----------------------- -AEAKAK---YEAEAAFFANL-KLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILK -KRHIVDTRQQEHIRSEKQI-M---QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWT ILRDRGSF---EDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGF AKK-----------------------IGFGK-KTWTFCGTPEYVAPEIILNK-GHDISAD YWSLGILMYE---LLTGSPPFSGPDP--MKTYNIILRGIDMIEFPKK-IAKNAANLIKKL C--DNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVAS---PTDTSNFD SFPEDNDEPP---PDDNSGW-------------DIDF----------------------- ------------------------------------------------------------ ----- >T_rubripes_ENSTRUP00000001539 MGNASMKSKRYKNADGSVTASNSWSHRDGRRLKNASLESLRVRVEELEREGKRRNEELQA KEQQIRSLQEQLARQTRVLAELSEELQTKCIQLSKLQDVMKSQGGAG--------TASRP TS---V--RKAGKSSPNLSVR-IKETLNRRKGAKAGVSAEPT-----SSSLPKFCFEKAR V---AKDNSVKKLLTDALNKNQYLRRLELQQIKDIVECMYERTYQRGEYVVKQGEPGNHL FVLAA--DGTLDVFQHNKLLTSITVWTTFGELAILYNC-TRTASVRAVNDVRTWALDREV FQNIMRRTAEMR-HEQYRNFLRS-VSLLANLPEDKLSKMVDCLEVEYYDKGEFIIREGEE GSTFYIIAQGKVKVTQTTEAHTFPQVINTLQKGDYFGEKA--LVS--DDVRSASILAEEN GVECLVIDRETFDQTVGTFSELQKHLQGYVATLDRDDRKRHA--RKKSVSRHQSQP---L SSDAICL---KEMVSTFSASR-PFDHLEVVATLGVGGFGRVELVKMQDKDVA-FALKIIK -KKHVVDNRQEEHIHSERKI-L---AEARSPFIVKLYRTFKDNKYVYMLLEACLGGEVWS LLRDRGNF---EEPTAKFCVGCVTEAFDYLHRKGILYRDLKPENLLLDAEGYIKLVDFGF AKK-----------------------IRCGQ-KTWTFCGTPEYVAPEIILNK-GHNFSVD FWSLGILVFE---LLTGSPPFSGSDQ--MMTYTFILKGIEKMDFPKK-ITKRPEDLIRKL C-RQNPAERLGNLKNGITDIKKHRWFNGFSWEGLKAKTLPSPLKRALTG---PTDHSYFD SYPPDEDS-P---PDELSGW-------------DVDF----------------------- ------------------------------------------------------------ ----- >O_latipes_ENSORLP00000007952 MGT----------------------------------------LRDLQYALQEKIEELRQ RDALIDELELELDQKDELIQRLQNELDKYRSVIKPATQ---QVHKQ-------------- -----------------------NELHEQQRTKRQAISAEPTAFDIQDLSHVTLPFY--- ----PKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLV Y-VME--DGKVEVTKENLKLCTMGPGKVFGELAILYNC-TRTATVKTLTNVKLWAIDRQC FQTIMMRTGLIK-HTEYMDFLKS-VPTFHDLQEDILSKLADVLEETHYAGGEYIIRQGAR GDTFFIISKGKVNVTREDLPNGEPVYLRSLGKGDWFGEKA--LQG--EDIRTASVIAAE- AVTCLVIDRDSFKHLIGGLED--------VSSKGHDD----------------------- -ADAKAK---YEAENAFFFSL-NLADFNIIDTLGVGGFGRVELVQLKSDENKTFAMKILK -KRHIVDTRQQEHIRSEKLI-M---QEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWT ILRDRGSF---EDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGF AKK-----------------------IGFGK-KTWTFCGTPEYVAPEIILNK-GHDISAD YWSLGILMFE---LLTGSPPFSGPDP--MKTYNIILRGIDMIEFPKK-ITKNAGNLIKKL C-RDNPCERLGNLKNGVKDIQKHKWFEGFNWEGLKKGTLTPPIIPNVTS---PVDTSNFD SFPEDNEDPP---PDDNSGW-------------DVDF----------------------- ------------------------------------------------------------ ----- >D_rerio_ENSDARP00000071397 MGNGSMKLNPLKQVSGSAKSKNN-------GESSLVPQVLRVRVEELETHLKKKDEDLNA KELQIKHLEEQLAQQKQTLSEISDTLRSKCLQLNKLQDALKSQGELG--------LLPSP LK---------EKVSQGLTGL-LRETLNRRKGAKAGVSAEPSSRTYDSSGIPKFYFESAR V---WKEQSVKKLLTDALNKNQYLRRLEVQQVKDMVECMYERTYQQGEYVIKQGEPGNHL F-VLA--DGKLDVYQHNKLLTSIAVWTTFGELAILYNC-TRTASVKAASNVKTWALDREV FHNIMRMTAEAR-HEQYRNFLRS-VSLLASLPGDKLTKIVDCLEVEYYNKGDYIIREGEE GNTFYIIANGKIKVTQSTQDHEEPQIINTLGKGDYFGEKA--LIS--DDVRSANIIAEED GVECLVIDRETFSQTVGTFDELKKYLQSYVDSLARDDKKRNA--KRSGSCTPPNTP---V SHDMIEL---KERESSFASTI-PFTCLEAIATLGVGGFGRVELVKLKNENVT-FALKCIK -KRHIVDNRQEEHIYSERRI-L---LETNCPFIVKMYRTYKDNKYVYMLLEACLGGEIWS LLRDRGSF---EEYTAKFCVGCVTEAFDYLHNNGIIYRDLKPENLMLDTDGYVKLVDFGF AKK-----------------------LKCGQ-RTWTFCGTPEYVAPEIILNK-GHGLSVD FWSLGILIFE---LLTGSPPFTGSDQ--MIIYTFILKGIEKMDFPKK-ITKRPGDLIRKL C-RQNPSERLGNLKNGITDIKKHRWFTGFSWSGLKARNLISPLKREVKG---PTDHSYFD SYPPEEEI-P---PDEMSGW-------------DTDF----------------------- ------------------------------------------------------------ ----- >M_domestica_ENSMODP00000025995 MGNGSVKPKQSKIPDGHAGKLSG------------TIDALRSKVTELERELKKKDDELQQ REYHLRELQEKLSKQTIALAEITEELQNKCIQLNKLQDVVNIQGGNS--------LLFSP YK-VPL--QVNRRTSGLVS-------LHSRRGAKEGVSAEPTTRTF-----AEFSFEKAR V---RKDSSDKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYPQGSYIIKQGEPGNHI F-VLA--EGRLEVFQGNKLLSSIPMWTTFGELAILYNC-TRTASVKAISNVKTWALDREV FQNIMRRTAQAR-DEQYRQFLRS-VCLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEE GSTFFILAKGVVKVTQSTEGYDQPQLIKTLKKGDYFGEKA--LIS--DDVRSANIIAEEN DVACLVIDRETFSQTVGTFEELQKYLEGYVANLNRDDEKRHA--KRSMSGWRQTKA---L SLEMIQL---KEKVAKFSSSS-PFQNLEIVTTLGVGGFGRVELVKVKNENVA-FAMKCIR -KKHIVDTKQQEHIYSEKKI-L---EEMCSPFIVKFYRTFKDRKYVYMLLEACLGGELWS ILRDRGSF---DEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGF AKK-----------------------IGSGQ-KTWTFCGTPEYVAPEVILNK-GHDFSVD FWSLGILVYE---LLTGNPPFSGIDQ--MMTYNLILKGIEKIDFPKK-ITRRPEDLIRRL C-RQNPTERLGNLKNGINDIKRHRWLNGFNWEGLKARSLPSPLKRELSG---PIDHSYFD NYPPEKGI-P---PDELSGW-------------DKDF----------------------- ------------------------------------------------------------ ----- >O_latipes_ENSORLP00000006529 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TEVTVVREGWLHKRGEYIKTWRPR YFILKSDGSFIGYKEKPDLGDSTSPPLNNFSVAECQIMKT--------ERPRPNTFVIRC LQWTTVIERTFHVESNVEREEWMQAIQSVANGLKMREQE-----EEPMDMFSSPCESSLE EMEVVMSKSRN-------KRK-TMNDFEYLKLLGKGTFGKVILVKEKSTGVH-YAMKILR -KMVIIAKDEVAHTVTESRV-L---QNTRHPFLTTLKYAFQTNDRLCFVMEYANGGELFF HLSRDRVF---TEDRARFYGAEIVSALEYLHSRDVVYRDLKLENLMLDKDGHIKITDFGL CKEG----------------------ITPDA-TMKTFCGTPEYLAPEVLEDN-DYGRAVD WWGLGVVMYE---MMCGRLPFYNQDH--ERLFELILME--EIRFPRN-LSPEAKSLLAGL L-KKDPKQRLGGGPNDAKEVMNHRFFININWQDVVQKKLTPPFKPQVTS---ETDTRYFD EEFTAQTI-TVTPPDKCLSDHALDCNDPIQEAHFPQFSYSASIRE--------------- ------------------------------------------------------------ ----- >D_rerio_ENSDARP00000043235 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------LVDFNIIDTLGVGGFGRVELVQLKSEETKTFAMKILK -KRHIVDTRQQEHIRSEKQI-M---QEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWT ILRDRGSF---EDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGF AKK-----------------------IGFGK-KTWTFCGTPEYVAPEIILNK-GHDISAD YWSLGILMYE---LLTGSPPFSGPDP--MKTYNIILRGIDMIEFPKK-ITKNAGNLIKKL C-RDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLIPPIIPDVAS---PTDTSNFD SFPED------------------------------------------------------- ------------------------------------------------------------ ----- >T_nigroviridis_ENSTNIP00000006171 MGT----------------------------------------LRDLQYALQLKIEELRQ RDTLIDELELELDQKDELIQRLQNELDKYRSVLRPATAQQVQAQQQS------------- ----------------------LVLQPDQHRSKRQAISAEPTACDISDLSHVTLPFY--- ----PKSPESKDMIREAILDNDFMKNLELSQIHEIVDCMYPVEYGKDACIIEEGDVGSLV Y-VME--EGKVEVTKEGMKLCTMGPGKVFGELAILYNC-TRTATVRTLVPVKLWAIDRQC FQTIMMRTGLIK-HAEYMDFLKS-VPTFKGLPEETLSKLADVMEETHYEDGDYIIRQGAR GDTFFIISNGKVNVTQEDSSNQEPVHLRELTRGDWFGERA--LQG--EDVRTANVIAAD- AVTCLVIDRDSFKHLIGGLEE--------VSNRGYED----------------------- -LEAKAK---YEAENAFFSSL-KLNDFNIVDTLGVGGFGRVELVQLKKEEAKTFAMKILK -KRHIVDTRQQEHIRSEKQI-M---SEAHCDFIVRLYRTFKDSKYLYMLMEACLGGELWT ILRDRGSF---DDSTTRFYTGCVVEAFAYLHAKGIIYRDLKPENLILDSYGYAKLVDFGF AKK-----------------------ISICK-KTWTFCGTPEYVAPEIILNK-GHDVSAD YWSLGILMYE---LLTGSPPFSGPDP--MKTYNIILRGIDMVEFPKK-VTKNASNLIKKL C-RDNPSERLGNQKNGVKDIQKHKWFEGFNWEGLRKGTLTPPITPDVSS---PTDTSNFD SFPEDTDEPP---PDDNSGW-------------DYDF----------------------- ------------------------------------------------------------ ----- >O_latipes_ENSORLP00000001301 MGNGSVKAPRAEENSCLPSIHAD--------APHLDSDILRVRITYLETELARRNQEFQT QELQLRRLQ--------------KELETKVSQIEKLQDAIHSHQTVG--------LSPTA LC---HHSCRHFSAINQGRFHKVAVEVHRRLRAKEGVSAEPPSADNFLWRYRPSSVSTAR TVHKNSDPSTKRLINEAILSNDFLKKLEPQHMREMVDCMYEKVYSEGQLVIQEGDAGNYL Y-VLA--EGLLEVIQNGKLLGEMHPGTAFGELAILYNC-KRTATVKAVLQSHIWTLERQT FQTIMMQTTQAR-HQEYFTFLRS-VSLLKQLPEEKLGRIVDCLEVEYFEKGEYIIREGEE GNTFFIIAKGQVTVTQSSEGFTQPQEIKTLGVGDYFGERA--LIS--EDVRSANIICNEN DTQCLVVDRDNFNQMVGTYEELQTYLKEYVGELSKSDERRHFLLSLRPHSQQSDSP---E AQELSRL---RERTARIPANQ-PFQELEVIATLGMGGFGRVELVKLKDEEST-FALKCIK -KKHVVDTRQQQHIYSEKKI-L---QQTNSSFIIRLFRTFRDNKYIYMLLEVCLGGELWT VLRDMSCF---EEQTARFCIGCVLEAFDYLHSMGIIYRDLKPENLLLDADGYVKMADFGF AKQ-----------------------IGIGR-KTWTFCGTPEYVAPEVIMNK-GHDFGAD CWSLGILVFE---LLTGNPPFSGSDP--IKIYTMVLHGIDRVDFPKR-IGKRPDDLIRRL C-KLNPVERIGNKKNGIMDIKKHKWFQGFNWEGLQGRKLPSPLKRELRG---PMDHSNFD MFPPNSEE-A---PDELSGW-------------DKDF----------------------- ------------------------------------------------------------ ----- >X_tropicalis_ENSXETP00000014175 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------SAKKLITGAIMSNDFVRQLEASHVRCMVDCMYERVYSKSQLVIQEGAAGNHL Y-VLA--DGLLDVIQNSRLLGQMHPGTAFGELAILYNC-KRTATVKAVTDSKIWVLDRQV FQNIMMSSAQAQ-HQEYFSFLRS-VSLLKDLPEEKLSKIVDCLEVDFYDKGDYIIREGEE GNTFFIIAKGKVRKYVMSNISQNFFLYKTKKVGKCFGAD---LFN--EDVRSANIIAEED DTQCLVIDRDTFNQMVGTYQELQTYLREYVFQLALNDHDRRN--ARRKSLHHSMSR---D NSEVNQL---RELVSKFSSTS-PFRYLDVITTLGTGGFGRVELVKLKDEDMT-FALKCIK -KKHIVDTHQQEHVYWEKNI-L---QQINCSFIIRLYRTFRDAKYVYMLLEVCLGGELWS ILRDTGPF---EEGTARFCTGCVLEAFDYLHNRGIVYRDLKPENLLLDSEGYIKMVDFGF AKK-----------------------IGPGK-KTWTFCGTPEYVAPEIIMNR-GHDFGAD YWSLGILIYE---LLTGSPPFSGTDP--IKIYNMVLKGIEKVDFPHR-IGRRSEDVIRRL C-RINPAERLGNRKNGISDIRKHKWFQGFNWEGLRNRKLLSPLKREIKG---ITDHSYFD NFLPESEE-P---PDELSGW-------------DKNF----------------------- ------------------------------------------------------------ ----- >D_rerio_ENSDARP00000090593 MGT----------------------------------------LRDLQYALQEKIEELRQ RDALIDELELELDQKDELIQKLQNELDKYRSVIRPATQ---QVQTR-------------- -----------------------SELPEHQRTKRQAISAEPA--NIQQLSHVTLPNV--- ----PKSAKSKDLIKSAILDNDFMKNLEMSQIQEIVDCMYPVDYDKNSCIIKEGDVGSLV Y-VME--DGKVEVTKEGLKLCTMGPGKVFGELAILYNC-TRTATVRTVSSVKLWAIDRQC FQTIMMRTGLIK-HAEYMELLKS-VLTFRGLPEEILSKLADVLEETHYEDGNYIIRQGAR GDTFFIISKGKVTMTREDCPGQEPVYLRSMGRGDSFGEKA--LQG--EDIRTANVIAAE- TVTCLVIDRDSYKHLIGGLED--------VSNKGCED----------------------- -AEAKAK---YEAENAFFSNL-NLSDFNIIDTLGVGGFGRVELVQLKSDEMKTFAMKILK -KRHIVDTRQQEHIRSEKLI-M---QEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWT ILRDRGNF---DDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGF AKK-----------------------IGFGK-KTWTFCGTPEYVAPEIILNK-GHDISAD YWSLGILMYE---LLTGSPPFSGPDP--MKTYNIILRGIDMIEFPKK-ITKNAANLIKKL C-RDTPSERLGNLKNGVKDIQKHKWFEGFNWDGLRKGTLMPPIIPNVTS---STDTSNFD SFPEDNEDPP---PDDNSGW-------------DIDF----------------------- ------------------------------------------------------------ ----- >T_rubripes_ENSTRUP00000026640 MSD----------------------------------------L-DEDFAKILLLKEERI RD-----LERRLADREDEIQELKRKLHKCQSVL-PSAQ---LIGPR-------------- ------------------------------TRRAQGISAEPQ--THQDLSRQTFRKY--- ----AKSDWSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLV Y-VME--DGKVEVTKESLKLCTMGPGKVFGELAILYNC-TRTATVKTLTNVKLWAIDRQC FQTIMMRTGLIK-QTEYMEFLKS-VPTFQGLQEDILSKLADVLEETHYEDGEYIIRQGAR GDTFFIISKGKVNVTREDSPSGEPVYLRSLGKGDWFGEKA--LQG--EDIRTANVIAAE- AVTCLVIDRDSFKHLIGGLEE--------VSSKGHED----------------------- -ADAKAK---YEAENAFFFNL-NLADFNIIDTLGVGGFGRVELVQLKSDENKTFAMKILK -KRHIVDTRQQEHIRSEKLI-M---QEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWT ILRDRGSF---EDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGF AKK-----------------------IGFGK-KTWTFCGTPEYVAPEIILNK-GHDISAD YWSLGILMFE---LLTGSPPFSGPDP--MKTYNIILRGIDMIEFPKK-ITKNAANLIKKL C-RDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLKKGTLTPPIIPTVTS---AVDISNFD NFPEDKEDPP---PDDNSGW-------------DVDF----------------------- ------------------------------------------------------------ ----- >T_guttata_ENSTGUP00000016175 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------QVTDFGF AKR-----------------------V--KG-RTWTLCGTPEYLAPEIILSK-GYNKAVD WWALGVLIYE---MAAGYPPFFADQP--IQIYEKIVSG--KVRFPSH-FSSDLKDLLRNL L-QVDLTKRYGNLKNGVNDIKNHKWFATTDWIAIYQRKV--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----- >S_cerevisiae_YKL126W MYSWKSKFKFGKSKEEKEAKHSGFFHSSKKEEQQNNQATAGEHDASITRSSLDRKGTINP SNSSVVPVRVSYD----------------------------------------------- ------------------------------------------------------------ ----ASSSTSTVRDSNGGNSENTNSSQNLDETANIGSTGTPNDATSSSGMMTIKVYNGDD FILPFPITSSEQILNKLLASGVPPPHKEISKEVDALIAQLSRVQIKNQGPADEDLISSES AAKFIPSTIMLPG-----------------------SSTLNPLLYFTIEFDNTVATIEAE YGTIAKPGFNKISTFDVTRKLPYLKIDVFARIPSILLPSKTWQQEMGLQDEKLQTIFDK- ------------INSNQDIHLDSFHLPINLSFDSAASIRLYN--HHWITLDNGLGK---I NISIDYKPSRN-------KPL-SIDDFDLLKVIGKGSFGKVMQVRKKDTQKV-YALKAIR -KSYIVSKSEVTHTLAERTV-L---ARVDCPFIVPLKFSFQSPEKLYFVLAFINGGELFY HLQKEGRF---DLSRARFYTAELLCALDNLHKLDVVYRDLKPENILLDYQGHIALCDFGL CKLN----------------------MKDDD-KTDTFCGTPEYLAPELLLGL-GYTKAVD WWTLGVLLYE---MLTGLPPYYDEDV--PKMYKKILQE--PLVFPDG-FDRDAKDLLIGL L-SRDPTRRLG--YNGADEIRNHPFFSQLSWKRLLMKGYIPPYKPAVSN---SMDTSNFD EEFTREKP-IDSVVDEYLSE--------SVQKQFGGWTYVGNEQLGSSMVQGRSIR---- ------------------------------------------------------------ ----- >G_aculeatus_ENSGACP00000013540 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RSKEMIKDAILDNDFMKNLELSQIQEVVDCMYPVDYGKDACIIKEGDVGSLV Y-VME--EGKVEVTKEGKKLCTMGPGKVFGELAILYNC-TRTATVMTLMHVKLWAIDRQC FQTIMMRTGLIK-HAEYMDFLKS-VPTFQGLPEETLTKLADVMEETHYEEGEFIIRQGAR GDTFFIISMGKVNVTQEDSANQEPAHLRVLSRGSWFGEKA--LQGHSEDVRTANVIAAE- AVSCLVIDRDSFNHLLGGLED--------VSVRGHED----------------------- -AEAKAR---YEAENTFFSSL-KLKDFNIIDTLGVGGFGRVELVQLKNEEAKTFAMKILK -KRHIVDTRQQEHIRSEKHI-M---TEAHSDFVVRLYRTFKDTKYLYMLMEACLGGELWT ILRDRGSF---EDSTTRFYTGCVVLAFAYLHAKGIIYRDLKPENLILDSRGYAKLVDFGF AKK-----------------------IGFCK-KTWTFCGTPEYVAPEIILNK-GHDVSAD YWSLGILMYE---LLTGSPPFSGPDP--MKTYNVILRGIDMIEFPKK-IPKNAASLIKKL CRRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLKKGTLTPPITPNVSS---PTDTGNFD NFPEDADEPP---PDDTSGW-------------DYDF----------------------- ------------------------------------------------------------ ----- >H_sapiens_ENSP00000372489 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MEAPGPAQAAAAESNSREVTE------D-------------------- --------------------------------------------A----ADWAPAL---C PS----P---EARSPEA-PAY-RLQDCDALVTMGTGTFGRVHLVKEKTAKHF-FALKVMS -IPDVIRRKQEQHVHNEKSV-L---KEVSHPFLIRLFWTWHEERFLYMLMEYVPGGELFS YLRNRGHF---SSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGF AKK-----------------------L--VD-RTWTLCGTPEYLAPEVIQSK-GHGRAVD WWALGILIFE---MLSGFPPFFDDNP--FGIYQKILAG--KLYFPRH-LDFHVK------ ---------TGRM----------------------------------------------- ------------------------------------M----------------------- ------------------------------------------------------------ ----- >X_tropicalis_ENSXETP00000000246 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------TVKTETAAGSNTLTYSKMRGMVALLIAFMKQR-------------------- --RMGLNDFIQKIATNSSYACKHSEVQSILNISPPQEPELLNE------NSSPPPS---P SQQINLGPSSN-------PHA-KPSDFQFLKIIGKGSFGKVLLARHNADEKF-YAVKVLQ -KKAILKKKEEKHIMSERNVLL---KNVKHPFLVGLHFSFQTTSRLYFILDYINGGELFY HLQRERCF---LEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIILTDFGL CKEN----------------------IEPNG-TTSTFCGTPEYLAPEVLHKQ-PYDRTVD WWCLGAVLYE---MLYGLPPFYSRNT--AEMYDNILNK--PLQLKPN-ITNSARNLLEGL L-QKDRTKRIGA-KNDFMEIKNHMFFSPINWDDLINKKITPPFNPNVSG---PSDLQHFD PEFTEEPV-PNSIGQSPDSI-LITASIKEAAEAFMGFSYAPPMESYL------------- ------------------------------------------------------------ ----- >T_nigroviridis_ENSTNIP00000011460 MGT----------------------------------------LRDLQYALQEKIEELRQ RDALIDELELELDQKDELIQRLQNELDKYRSVIKPATQ---QVHKQ-------------- -----------------------TELQEHQRTKRQAISAEPTAFDIQDLSHVTLPFY--- ----PKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLV Y-VME--DGKVEVTKESLKLCTMGPGKVFGELAILYNC-TRTATVKTLTNVKLWAIDRQC FQTIMMRTGLIK-HTEYMEFLKS-VPTFQGLQEDILSKLADVLEETHYEDGEYIIRQGAR GDTFFIISKGKVNVTREDSPNGEPVYLRSLGKGDWFGEKA--LQG--EDIRTANVIAAE- AVTCLVIDRDSFKHLIGGLED--------VSSKGHED----------------------- -ADAKAKRDRYEAENAFFFNL-NLADFNIINTLGVGGFGRVELVQLKSDENKTFAMKILK -KRHIVDTRQQEHIRSEKLI-M---QEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWT ILRDRGSF---EDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGF AKK-----------------------IGFGK-KTWTFCGTPEYVAPEIILNK-GHDISAD YWSLGILMFE---LLTGSPPFSGPDP--MKTYNIILRGIDMIEFPKK-ITKNAANLIKKL C-RDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLKKGTLTPPIIPNVTS---AIDTSNFD SFPEDNEDPP---LDDNSGW-------------DVDF----------------------- ------------------------------------------------------------ ----- >S_cerevisiae_YHR205W MMNFFTSKSSNQDTGFSSQHQHPNGQNNGNNNSSTAGNDNGYPCKLVSSGPCASSNNGAL FTNFTLQTATPTTAISQDLYAMGTTGITSENALFQ------------------------- ------------------------------------------------------------ ----MKSMNNGISSVNNNNSNTPTIITTSQEETNAGNVHGDTGGNSLQNSEDDNFSSSST TKCLLSSTSSLSINQREAAAAAYGPDTDIPRGKLEVTIIEARDLVTRSKDSQPYVVCTFE SSEFISNGPESLGAINNNNNNNNNNQHNQNQHINNNNENTNPDAASQHHNNNSGWNGSQL PSIKEHLKKKPLYTHRSSSQLDQLNSCSSVTDPSKRSSNSSSGSSNGPKNDSSHPIWHHK TTFDVLGSHSELDISVYDAAHDHMFLGQVRLYPMIHNLAHASQHQWHSLKPRVIDE--VV SGDILIK---WTYKQTKKRHY-GPQDFEVLRLLGKGTFGQVYQVKKKDTQRI-YAMKVLS -KKVIVKKNEIAHTIGERNI-LVTTASKSSPFIVGLKFSFQTPTDLYLVTDYMSGGELFW HLQKEGRF---SEDRAKFYIAELVLALEHLHDNDIVYRDLKPENILLDANGNIALCDFGL SKAD----------------------L--KD-RTNTFCGTTEYLAPELLLDETGYTKMVD FWSLGVLIFE---MCCGWSPFFAENN--QKMYQKIAFG--KVKFPRDVLSQEGRSFVKGL L-NRNPKHRLGAIDDG-RELRAHPFFADIDWEALKQKKIPPPFKPHLVS---ETDTSNFD PEFTTAST---SYMNKHQPMMTATPLSPAMQAKFAGFTFVDESAIDEHVNNNRKFLQNSY FMEPGSFIPGNPNLPPDEDVIDDDGDEDINDGFNQEKNMNNSHSQMDFDGDQHMDDEFVS GRFEI >A_carolinensis_ENSACAP00000010068 MGNGSVKHKYLKRQEGHAGNCPP-------------RYILRSKVWELERELKRQEEELHE RNYHILELQDQLAKQTRTIADLTEELKCKCIQLNKLQDVVDTQGTNP--------FLFSP LKEVP-------KVSPVPC-------SNRRKGAKEGVSAEPTSRTYDLTEQPRFSFEKAR V---RKASSEKKLITEALSRNQFLKRLDPQQIRDMVECMYGRTYQQGSYIIKQGEPGNHI F-VLA--EGKVEVFQQNKLLSSIPVWTAFGELAILYNC-TRTASVKAVTIVKTWALDREV FQNIMRRTAQAR-HDQYRNFLRS-VSLLKNLPEDKLSKIVDCLEVEYYDKGDYIIREGEE GNTFFVIAKGKVKVTQTTDGQPQTQLIKTLQKGDYFGERA--LIS--DDVRSANIIADEN DVECLVVDRETFNQTVGTFEELQAYLAGYVATLARDDEKRNA--Q-VSSLERLPSD---V SLEMIQL---KEKVAQFPSSC-PFQNLEIVATLGVGGFGRVELVKLKNESIA-FAMKCIK -KKHIVDTKQQEHIHSEKRI-L---EEACSPFIVRLYRTFKDNKYVYMLLEACLGGELWS ILRDRGSF---DETTTKFCVGCVTEAIEYLHCISVIYRDLKPENLILDAHGYIKLVDFGF AKK-----------------------IAIGQ-KTWTFCGTPEYVAPEVILNK-GHDFSVD FWSLGILVYE---LLTGNPPFSGADQ--MTTYNLILKGVERLDFPRI-VSKRPEDLIRRL C-RQNPTERLGNLKNGIHDIKRHRWLNGFNWEGLKARKLSSPLKRELSG---PMDYSYFD RYPPDQGI-P---PDELSGW-------------DKDF----------------------- ------------------------------------------------------------ ----- >G_aculeatus_ENSGACP00000012095 MGT----------------------------------------LRDLQYALQEKIEELRQ RDALIDELELELDQKDELIQRLQTELDKYRSVIKPATQ---VV-KQ-------------- -----------------------NDLHEQQRTKRQAISAEPTAFDIQDLSHVTLPFY--- ----PKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLV Y-VME--DGKVEVTKESLKLCTMGPGKVFGELAILYNC-TRTATVKTLTNVKLWAIDRQC FQTIMMRTGLIK-HTEYMEFLKS-VPTFHGLQEDILSKLADVLEETHYGDGEYIIRQGAR GDTFFIISKGKVNVTREDLPNIEPVYLRSLGKGDWFGEKA--LQG--EDIRTANVIAAE- AVTCLVIDRDSFKHLIGGLEE--------VSSKGHED----------------------- -ADAKAK---YEAENAFFFNL-NLADFNIIDTLGVGGFGRVELVQLKSDENKTFAMKILK -KRHIVDTRQQEHIRSEKLI-M---QEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWT ILRDRGSF---EDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGF AKK-----------------------IGFGK-KTWTFCGTPEYVAPEIILNK-GHDISAD YWSLGILMFE---LLTGSPPFSGPDP--MKTYNIILRGIDMIEFPKK-ITKNAGNLIKKL CSRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLKKGTLTPPIVPNVTS---AVDTSNFD SFPEDNEDPP---PDDNSGW-------------DVDF----------------------- ------------------------------------------------------------ ----- >C_familiaris_ENSCAFP00000013673 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------QGSLA--LGRRCADRGRCTGLGGGRECRCLKP-------------------- --FL-----PQQQLSR--------DWSPLCPYSSPDHCYRMDS-SRAGTPSPQPSR---A NGNINLGPSAN-------PNA-RPTDFDFLKVIGKGSYGKVLLAKRKSDGMF-YAVKVLQ -KKSILKKKEQNHIMAERSVLL---KNVQHPFLVGLRYSFQTPEKLYFVLDYVNGGELFF HLQRERRF---LEPRARFYAAEVASAIGYLHSLNVIYRDLKPENILLDCQGHVVLTDFGL CKEG----------------------VEPEE-TTSTFCGTPEYLAPEVLRKE-PYDRAVD WWCLGAVLYE---MLQGLPPFYSQDV--SQMYENILYQ--PLQIPGG-QTVAACDLLQGL L-HKDQRQRLGS-KSDFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVAG---PADLKHFD PEFTQEAV-SKSIGCTPDTV----AGSSGTSSAFLGFSYAPEDEAILDY----------- ------------------------------------------------------------ ----- >X_tropicalis_ENSXETP00000046551 MGNGSMKSKPLKQPDGQRVNFSI-----SSCNKLRNADTVKNKVWELEIELKKKDEKLKN KEQIFQELQEQIKKQNQVIEEMAEELQNKCVQLNKLQVVVQTQNGISTTPDLHKMLQPSP TKTLHALPTKSLKGSPLKTFSGLFSNSNKRKGAKEGVSAEPTSR-YDGGDHPRFSFEKAR V---RKNTSEKILISDALNKNQFMKRMDHHQIQDMVECMYERIYLQGEFIIRQGEPGSQI F-VLA--DGKAEVFQENKLLTSIPVWTTFGELAILYNC-TRTASVKAITGVRTWALDREV FQNIMRKTAQSK-HEEYLSFLRAIVPLLKELPEHKLMKIADCLELEFYEMDDYIIREGEE GSTFFIISKGKVKVTQSTEGYKEPQYIKFLEKGDYFGEKA--LIS--DDVRSANILAYGD RVECLVMDRETFNKTVGTYEELMKCLEGYVANLTLDDERRHA--K-SPVNERHLRA---V SMELNKM---KQTLARFPSAS-PFENLEIVTTLGVGGFGRVELVKVKNENLV-FALKCIK -KRHIVDNRQQEHIHSEKNI-L---EEACSPFIVKLYCTFKDNKYVYMLLEACLGGELWS ILRDRGSF---DEPTAKFCTGCVTEAFEYLHQKGVLYRDLKPENLLLDSEGYVKLVDFGF AKK-----------------------IFPGQ-KTWTFCGTPEYVAPEVILNK-GHSFSVD FWSLGILLYE---LLTGSPPFTGPDQ--MIIYNLILQGIEKIEFYKN-ITKRPEDLIRRL C-RENPAERLGNMKNGIADIKKHRWFNGFNWEGLNTRSLPSPLKPELEG---PTDHSYFD SYPPDEEI-P---PDEVSGW-------------DQDF----------------------- ------------------------------------------------------------ ----- >O_latipes_ENSORLP00000020683 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------TVITE--AEKPALTYSKTRGLVGLVSAFMKQR-------------------- --RMGLNDFIQRLATN-SYACKHPEVQSILNLSPPQDAELMNV------NPSPPSS---P SQQINLGPSSN-------PSA-KPSDFHFLKVIGKGSFGKVLLARHRTDDQF-YAVKVLQ -KKAILKKKEEKHIMSERNVLL---KNVKHPFLVGLHYSFQTADKLYFVLDYINGGELFY HLQRERCF---LEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIILTDFGL CKEN----------------------IEPNG-TTSTFCGTPEYLAPEVLHKQ-PYDRTVD WWCLGAVLYE---MLYGLPPFYSRNT--AEMYDNILNK--PLQLKPN-ISNSARNLLEGL L-QKDRTKRLGC-TNDFIEIKNHVFFSPINWDELNAKKITPPFNPNVTG---PNDLRHFD PEFTDEPV-SSSIGCSPDSA-LFTASIKEAAEAFVGFSYAPSMDSYL------------- ------------------------------------------------------------ ----- >O_latipes_ENSORLP00000011360 C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------IQKTATQERPMTYAKMKGIVTFFSVLLKGK-------------------- --KVAFSDFLHKVAHS-KFFCQHPETQKHLRRKRLSEHRLPTS-NP---NHSVPKS---Q VQQIEKKMKKE-------SRV-TPSDFEFLKVIGSGTFGKVLLARHRKQGGL-YAVKVLQ -KQMVIKRKEQRHVMVERSVLL---KGLGNPFLVGLHFSFQTPNALYFVLDYVNGGELFY HLQREGSF---PEPRAGFYAAELAGALGYLHSLQIVYRDLKPENILLDSEGHVMLTDFGL CKEG----------------------VSVGEIMNNTFCGTQQYLAPEVLQGQ-PYSSAVD WWGLGVVLFE---MLTGMPPFYSPRK--VEMFENILHA--PLQLPSG-VSGAAHSLLAGL L-DRDISKRLGE-KRDFEEIQEHNFFAFINWDDLLARKVIPPFIPNVTG---PGDVSYID PEFTLQPV-PASVTDRCQAV--------CASEAFPGFSFINSADCVA------------- ------------------------------------------------------------ ----- >T_rubripes_ENSTRUP00000002807 MGT----------------------------------------LRDLQYALQLKIEELRQ RDTLIDELELELDQKDELIQRLQNELDKYRSVLRPATAQQVQAQQQS------------- ----------------------LVLQPDQHRSKRQAISAEPTACDISDLSHVTLPFY--- ----PKSPQSKEMIREAILDNDFMKNLELSQIHEIVDCMYPVEYGKDACIIEEGDVGSLV Y-VME--EGKVEVTKEGMKLCTMGPGKVFGELAILYNC-TRTATVRTLVHVKLWAIDRQC YQTIMMRTGLIK-HAEYMDFLKS-VPTFKGLPEETLSKLADVMEETHYEDGDYIIRQGAR GDTFFIISNGKVNVTQEDPDNQGPVHLRELTRGDWFGERA--LQG--EDVRTANVMAAD- AVTCLVIDRDSFKHLIGGLEE--------VSNRGYED----------------------- -VEAKAK---YEAENAFFSGL-KLNDFNIVDTLGVGGFGRVELVQLKKEEAKTFAMKILK -KRYIVDTRQQEHIRSEKQI-M---SEAHCDFIVRLYRTFKDRKYLYMLLEACLGGELWT LLRDRGSF---DDTTTRFYTGCVVEAFAYLHAKGIIYRDLKPENLLLDSHGYAKLVDFGF AKK-----------------------IGLCK-KTWTFCGTPEYVAPEIILNK-GHDVSAD YWSLGILMYE---LLTGSPPFSGPDP--MKTYNIILRGIDMVEFPKK-VTKNATNLIKKL C-RDNPSERLGNQKSGVKDIQKHKWFEGFNWEGLRKGTLTPPIRPDVSS---PTDTSNFD SFPEDTDEPP---PDDNSGW-------------DYDF----------------------- ------------------------------------------------------------ ----- >D_rerio_ENSDARP00000085704 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TKKLINEALMKNDFLKKLEPQHTREMVDCMYEKIYGAEQLVIQEGEPGNFL Y-VLA--EGLLEVIQNGKFLGQMRPGTAFGELAILYNC-KRTATVKAVSQSHIWALDRQT FQTIMMRSTQAR-HEEYFSFLRS-VSLLKDLPEEKLAKIIDCLEIDYFDKGEYIIREGEE GNTFFIIAKGEVSVTQTTEGFTEPQEIKTLRVGDYFGEKA--LIS--EDVRSANIIAKEN DTQCLVVDRDNFNEMVGTYEEL-----------------------------QERSP---E AAELRRL---KEKATALSSTS-FLKELQVVATLGMGGFGRVELVKLKDSEDTAFALKCIK -KKHIVDTRQQEHIYSEKII-L---QQTNSNFIVRLFRTFRDDKFVYMLLEVCLGGELWS LLRDMSCF---DEPTARFCTGCVLEAFDYLHGKGIVYRDLKPENLLLDAEGYVKMADFGF AKK-----------------------IGLGK-KTWTFCGTPEYVAPEVIMNK-GHDFGAD CWSLGILIFE---LLIGSPPFTGSDP--IRIYTMVLHGIEKVDIPKR-ISKRPEDLIRRL C-KLNPAERLGNKKNGIIDIKKHKWFQGFNWEGLRRRKLMSPLRRELKG---PLDHSYFD MFPPELEE-P---PDEFSGW-------------DKDF----------------------- ------------------------------------------------------------ ----- >G_aculeatus_ENSGACP00000002402 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------EYYDKGEHVIREGEE GSTFYIIAQGKVKVTQTTEDHQLPQTINTLQKGDYFGEKA--LIS--DDVRSANIIAEEN GVECLVIDRETFNQTVGTFNELQKYLEGYVATLDRDDKKRHA--R-RSVSRHQSQP---L SADVIQL---KDRVSAFPPSR-PFEHLEVIATLGVGGFGRVELVKVQDEDVT-FALKVIK -KKHIVDNRQEEHIHSERKI-L---TEARSPFVVKLYRTFKDNKYVYMLLEACLGGEIWS LLRDRGSF---DEPTAKFCVGCVTEAFDYLHRKGVLYRDLKPENLMLDAEGYIKLVDFGF AKK-----------------------IRCGQ-KTWTFCGTPEYVAPEIILNK-GHNFSVD FWSLGILVFE---LLTGSPPFTGSDQ--MMTYTFILKGIEKMDFPKK-VTKRPEDLIRKL C-RRNPSERLGNLKNGITDIKKHRWFNGFNWEGLKAMTLPSPLKRELTG---PTDHSYFD SYPPDEDS-P---PDELSGW-------------DMDF----------------------- ------------------------------------------------------------ ----- >B_taurus_ENSBTAP00000028014 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MDS-SPAGTPSPQPLR---A NGNINLGPSAN-------PNA-RPTDFDFLKVIGKGNYGKVLLAKHKSDGMF-YAVKVLQ -KKSILKKKEQSHIMAERSVLL---KNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFF HLQRERRF---LEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL CKEG----------------------VEPEE-TTSTFCGTPEYLAPEVLRKE-PYDRAVD WWCLGAVLYE---MLHGLPPFYSQDV--SQMYENILHQ--PLRIPGG-RTVAACDLLQAL L-HKDQRQRLGS-KTDFLEIKSHVFFSPINWDDLYHKRLTPPFNPNVAG---PADLKHFD PEFTQEAV-SKSIGCTPDTM----ASSSGASSAFLGFSYAPDDDAILDC----------- ------------------------------------------------------------ ----- >D_rerio_ENSDARP00000021458 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------VKKAKSPVTYAKMKGIVSYFTALIKDK-------------------- --KLRSSHPIYH--------------------------------QMDFLRPEGSLS---D DDRATAVCYSNPVREEPQSQV-SAGDFDYLKVIGTGSFGKVFLATHRENGKY-YAVKVLQ -KHIILTRKEERNVMCEHRVLL---KTLNHPFLVKLHFSFQTKERLYLVLDYACGGELFY HLQREGVF---GEARARFYAAEMACALGYLHSLKIVYRDLKPENILLDSAGHVVLTDFGL CKEG----------------------MSGRG-TTRTFCGTPEYLAPEVLLQE-EYDRTVD WWGLGAVLHE---MLYGLPPFYNADR--LEMLRNIIYQ--PLALKAG-VSSAARDLLKRL L-NRDRAKRLGA-KRDLIELQSHAFFSPIQWDELVAKKIQPPYVPVLSG---PGDLTNID PRFTELPV-PHSLGACEDHG-----------ANFPGFTFINENILSLTRGH--------- ------------------------------------------------------------ ----- >H_sapiens_ENSP00000340608 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------QGLLT--SGRKPSGGGRCTGRGGWRGQWCLKP-------------------- --WMGGADPPTPTLSC--------LLLPV-PPELPDHCYRMNS-SPAGTPSPQPSR---A NGNINLGPSAN-------PNA-QPTDFDFLKVIGKGNYGKVLLAKRKSDGAF-YAVKVLQ -KKSILKKKEQSHIMAERSVLL---KNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFF HLQRERRF---LEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL CKEG----------------------VEPED-TTSTFCGTPEYLAPEVLRKE-PYDRAVD WWCLGAVLYE---MLHGLPPFYSQDV--SQMYENILHQ--PLQIPGG-RTVAACDLLQSL L-HKDQRQRLGS-KADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTG---PADLKHFD PEFTQEAV-SKSIGCTPDTV----ASSSGASSAFLGFSYAPEDDDILDC----------- ------------------------------------------------------------ ----- >P_troglodytes_ENSPTRP00000023198 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------QGLLT--SGRKPSGGGRCTGRGGWRGQWCLKP-------------------- --WMGGADPPTPTLSC--------LLLPV-PPELPDHCYRMNS-SPAGSPSPQPSR---A NGNINLGPSAN-------PNA-RPTDFDFLKVIGKGNYGKVLLAKRKSDGAF-YAVKVLQ -KKSILKKKEQSHIMAERSVLL---KNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFF HLQRERRF---LEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL CKEG----------------------VEPED-TTSTFCGTPEYLAPEVLRKE-PYDRAVD WWCLGAVLYE---MLHGLPPFYSQDV--SQMYENILHQ--PLQIPGG-RTVAACDLLQSL L-HKDQRQRLGS-KADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTG---PADLKHFD PEFTQEAV-SKSIGCTPDTV----ASSSGASSAFLGFSYAPEDGDILDC----------- ------------------------------------------------------------ ----- >D_rerio_ENSDARP00000031762 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------TIQTETSVSAPDLTYSKTRGLVANLSAFMKQR-------------------- --KMGLNDFIQKLSAN-SYACKHPEVQSILNLTPPQDVELMNS------NPSPPPS---P SQQINLGPSSN-------PTA-KPSDFDFLKVIGKGSFGKVLLARHRSDEKF-YAVKVLQ -KKAILKKKEEKHIMSERNVLL---KNVKHPFLVGLHYSFQTTDKLYFVLDYINGGELFY HLQRERCF---LEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIILTDFGL CKEN----------------------IEPNG-TTSTFCGTPEYLAPEVLHKQ-PYDRTVD WWCLGAVLYE---MLYGLPPFYSRNT--AEMYDNILNK--PLQLKPN-ISNAARHLLEGL L-QKDRTKRLGF-TDDFTEIKNHMFFSPINWDDLNAKKLTPPFNPNVTG---PNDLRHFD PEFTDEPV-PNSIGCSPDSA-LVTSSITEATEAFLGFSYAPAMDSYL------------- ------------------------------------------------------------ ----- >M_mulatta_ENSMMUP00000037955 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------QGLL---AGRKPSGGGRCTGRGGWRGQWCLKP-------------------- --WMGEAGPTTPALSC--------LLLPV-PPELPDHCYRMNS-NPAGTTSPQPSK---A NGNINLGPSAN-------PNA-RPTDFDFLKVIGKGNYGKVLLAKRKSDGTF-YAVKVLQ -KKSILKKKEQSHIMAERSVLL---KNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFF HLQRERRF---LEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL CKEG----------------------VEPEE-TTSTFCGTPEYLAPEVLRKE-PYDRAVD WWCLGAVLYE---MLHGLPPFYSQDV--SQMYENILHQ--PLQIPGG-RTVAACDLLQSL L-HKDQRQRLGS-KADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVAG---PADLKHFD PEFTQEAV-SKSIGCTPDTV----ASSSGASSAFLGFSYAPEDDDILDC----------- ------------------------------------------------------------ ----- >R_norvegicus_ENSRNOP00000040718 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MAS-SPVGVPSPQPSR---A NGNINLGPSAN-------PNA-RPTDFDFLKVIGKGNYGKVLLAKRKSDGAF-YAVKVLQ -KKSILKNKEQSHIMAERNVLL---KNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFF HLQREHRF---LEPRARFYTAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL CKEC----------------------VEPEE-TTSTFCGTPEYLAPEVLRKE-PYDRAVD WWCLGAVLYE---MLHGLPPFFNTDV--AQMYENILHQ--PLQIPGG-RTVAACDLLQGL L-HKDQRQRLGS-KEDFLDIKNHMFFSPINWDDLYHKRLTPPFNPNVEG---PADLKHFD PEFTQEAV-SKSIGCTPDTM----SSSSGASSAFLGFSYAQDDDDILDS----------- ------------------------------------------------------------ ----- >M_musculus_ENSMUSP00000018012 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MAS-SPVGVPSPQPSR---A NGNINLGPSAN-------PNA-RPTDFDFLKVIGKGNYGKVLLAKRKSDGAF-YAVKVLQ -KKSILKNKEQNHIMAERNVLL---KNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFF HLQRERRF---LEPRARFYTAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL CKEC----------------------VEPEE-TTSTFCGTPEYLAPEVLRKE-PYDRAVD WWCLGAVLYE---MLHGLPPFFNTDV--AQMYENILHQ--PLQIPGG-RTVAACDLLQGL L-HKDQRQRLGS-KEDFLDIKNHMFFSPINWDDLYHKRLTPPFNPNVEG---PADLKHFD PEFTQEAV-SKSIGCTPDTV----ASSSGASSAFLGFSYAQDDDDILDS----------- ------------------------------------------------------------ ----- >M_mulatta_ENSMMUP00000021684 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------LQNFDTLAIVGTGMFGRVDPVKKKTAKHF-FALKVMS -IHDVIRLKQEQHMHIER------------------------------FMEYLPGGELFS YPRNRGRF---SSAKGLFYSAEITCAIEYLHSKQIVYR-LKPENILLDRDGHIKLMDFGF AEK-----------------------L--VD-RTWTLCGTPEYLAPKVIQSE-GHGRAVD WWALGILIIRDALRVSSLCVCVCDNT--FGIYQKILAG--KIDFPRH-LNFCVKDLIKKL L-VVDRTRRLGNMKNRANDVKRHRWFRSVDWEAVPQRKLKPPIVPKIAR---DGDTSNFE TYPEND------------------------------------------------------ ------------------------------------------------------------ ----- >M_domestica_ENSMODP00000021847 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------TVKTE--ASGATLTYSKMRGMVAILIAFMKQR-------------------- --RMGLNDFIQKIASN-SYACKHPEVQSILKISQPQEPELMNA------NPSPPPS---P SQQINLGPSSN-------PHA-KPSDFHFLKVIGKGSFGKVLLARHKAEEQF-YAVKVLQ -KKAILKKKEEKHIMSERNVLL---KNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFY HLQRERCF---LEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGL CKEN----------------------IEHNG-TTSTFCGTPEYLAPEVLHKQ-PYDRTVD WWCLGAVLYE---MLYGLPPFYSRNT--AEMYDNILNK--PLQLKPN-ITNSARHLLEGL L-QKDRTKRLGA-KDDFMEIKNHIFFSLINWDDLINKKITPPFNPNVSG---PNDLRHFD PEFTEEPV-PNSIGKSPDSI-LITASVKEAAEAFLGFSYAPPMDSFL------------- ------------------------------------------------------------ -----