10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000314132 MEVLRRSSVFAAEIM--------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000015296 MEVLRRSSVFAAEIM--------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000007481 MEVLRRSSVFAAEIM--------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000014939 MEVLRRSSVFAAEIM--------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000027499 MEVLRRSSVFAAEIM--------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000024693 MEVLRRSSVFAAEIM--------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000011478 MEVLRRSSVFAAEIM--------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000020066 MEVLRRSSVFAAEVM--------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000006267 MEVLRRSSVFAAEVM--------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000008963 MEVLRRSSVFAAEVM--------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000000851 MDVLRRSSVFAAEVM--------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000009257 MEVLRRSSVFAAEVM--------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000068408 MEMLRRSSVFAAEVM--------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000006084 MDMLRRSSVFAA------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005841 MEMLRRSSMFAA------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000030263 MEMLRRSSVFAA------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000002641 LESMRACGVARVNPA--------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000000132 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000018321 MEVLRRSSVFAAEVL--------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000018053 MEVLRRPSVMAAEVL--------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000090569 MNVFARSSVLAAEMM--------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000018728 MEVLRRSSVFAAEVL--------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000020538 MDVLRRSSVFAAEVL--------------------------------------------------------------------------------------------------------- A_aegypti_AAEL001515-PA MEMTSP---------------------------------------------------------------------------TLANNFANVWTNRR------------------------- A_gambiae_AGAP011552-PA MSSTAG--------------AFHQQHQPQQQSPRSPIVAAAVAAAAAIGAVSGG-----------------------------SAGGVVGWTNKR------------------------- A_aegypti_AAEL001521-PA MLSAEAPVSHNHHLL--------PDRLSAPALARRKFSFPANLHSTVLHGDPPGSINSGSLQPSSTASFARRRLSNVSDVVTRK------LSSTI------------------------- D_melanogaster_FBpp0085443 MAPTTSPPP-----KLAKFKSSSLDHEIYTANRRGTIATASSDWKALRGGVGGG-----AGGPGSVPNPSNGRSLHAGGPMTRAASTSSLASSTR------------------------- D_melanogaster_FBpp0087182 MPGTSYPTNNDNFSNGFPMATTQSERL-LQAQNRRKFSFPATLHSASLLEVGGG--------PKET---TRRRLSNVSDAVTRK------LSYTI------------------------- C_intestinalis_ENSCINP00000019812 MTSYTSDVNHNSIYETERKNKRTLLADNINSIMRDSVTFVTSSIADLTSSCVSLGD---------------------------------------------------------------- C_intestinalis_ENSCINP00000016140 MTSHESENASGFLKPEMESQRRHSWDGRFSTNKIDLGGESTVCRNDSKGRRRRELRRSHVVTEAPDVTLFEEQDQNNASTIPTKDDPTPVASENKNTNNRPWGLRRRITKTENHCEKIED D_rerio_ENSDARP00000089067 MADGKNGETTD-ENELKG------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000095258 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018700 MASH-------------------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000018978 MADGGREKQDDGDREPRG------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000014135 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005643 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000007577 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000012873 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000017160 MDGSGEQP---------------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000006866 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000052058 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000293288 MDGSGEQP---------------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000000549 MASGQGPGPPGQDCDEPDPSS--------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000021005 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013488 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011187 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000017513 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000032199 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000040259 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000014770 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000031936 RKKGNNGVKDRDWEEQHATGNIIFRGSPD------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000050759 MATHGAGGDYPGEDKEKNQGEGGAAGGPSLGAAG-------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000008572 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000017211 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000005209 MDGSGEQP---------------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000086454 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000019323 MDGSGEQP---------------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000007865 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000010478 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000365230 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000012163 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000022903 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000010059 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000053903 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000024313 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000017311 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000023687 MAAP-------------------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000002788 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000096467 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002775 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000017739 MDGSGEQP---------------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000013781 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000014671 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000003768 M----------------------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000017662 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000016202 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000022806 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000036334 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000021385 MASGQGPGPPGKECGEPAPSS--------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000005745 MASH-------------------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000005598 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000010122 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000028328 MDGSGDHL---------------------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000005553 MDGSGEQS---------------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000001415 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000019355 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000033093 MDGSGEQL---------------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000017228 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250405 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002204 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000026248 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000008404 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010457 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000002093 M----------------------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000077757 MASGQGPGPPKVGCDE--SPS--------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000020984 M----------------------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000056677 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000015983 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000000576 MASGQGPGPPKGDCDE--ALS--------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000023449 FKKNAVIGLNLYCGGAGMGAGGGASGPPSGGRLLASGKGPTVESTPPQRDGGEVETGTAGAGLIGGGIRASPPNPVSPGARGVARPAPIGAEAPDVTTDPMPSLFAPGRCSSAPAEVAD- E_caballus_ENSECAP00000017850 M----------------------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000108371 M----------------------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000039057 MEGNEGDPPGAHRRRDSHGRR--------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000056470 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000000102 M----------------------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000010113 MDGSGEQP---------------------------------------------------------------------------------------------------------------- 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000314132 ----------------------------------------------------------------------------------DAFDRS-PTDKELVAQAKALGREYVHARLLRAGLSWSA G_gorilla_ENSGGOP00000015296 ----------------------------------------------------------------------------------DAFDRS-PTDKELVAQAKALGREYVHARLLRAGLSWSA M_mulatta_ENSMMUP00000007481 ----------------------------------------------------------------------------------DAFDRS-PTDKELVAQAKALGREYVHARLLRAGLSWSA P_pygmaeus_ENSPPYP00000014939 ----------------------------------------------------------------------------------DAFDRS-PTDKELVAQAKALGREYVHARLLRAGLSWSA M_musculus_ENSMUSP00000027499 ----------------------------------------------------------------------------------DAFDRS-PTDKELVAQAKALGREYVHARLLRAGLSWSA R_norvegicus_ENSRNOP00000024693 ----------------------------------------------------------------------------------DAFDRS-PTDKELVAQAKALGREYVHARLLRAGLSWSA B_taurus_ENSBTAP00000011478 ----------------------------------------------------------------------------------DAFDRS-PTDKELVAQAKALGREFVHARLLRAGLSWSA M_domestica_ENSMODP00000020066 ----------------------------------------------------------------------------------EVFDRS-PTDKELVSQAKALGREYIHSRLIRAGLVWSK T_guttata_ENSTGUP00000006267 ----------------------------------------------------------------------------------EVFDRS-PTDKELVSQAKALCRDYINSRLIQAGVSWSK O_anatinus_ENSOANP00000008963 ----------------------------------------------------------------------------------EVFDRS-PTDKELVSQAKALCREYIHSRLIRASLVWSK A_carolinensis_ENSACAP00000000851 ----------------------------------------------------------------------------------EVFDRT-PTDKELVSQAKVLCRDFIHSRLIRAGIGWNK G_gallus_ENSGALP00000009257 ----------------------------------------------------------------------------------EVFDRS-PTDKELVSQAKALCRDYINSRLIRAGVSWSK D_rerio_ENSDARP00000068408 ----------------------------------------------------------------------------------EVFDRS-PTDKELVSQSKVLCRDYIHSRLHRAGIGWSK G_aculeatus_ENSGACP00000006084 ----------------------------------------------------------------------------------EVFDRS-PTDKELVSQAKALCRDYIHSRLNRAGMGWSK T_nigroviridis_ENSTNIP00000005841 ----------------------------------------------------------------------------------EVFDRS-PTDKELVSQAKALCRDYIHSRLNRAGIGWSK T_rubripes_ENSTRUP00000030263 ----------------------------------------------------------------------------------EVFDRS-PTDKELVSQAKALCRDYIHSRLNRAGVGWSK O_latipes_ENSORLP00000002641 ----------------------------------------------------------------------------------QAFSRSAPTDKELVSQAKALCREYIHSRLNRAGIGWSK E_caballus_ENSECAP00000000132 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000018321 ----------------------------------------------------------------------------------DVFDRS-LTEKELVSHSKALCRDYILSRLTQSGLGWSK G_aculeatus_ENSGACP00000018053 ----------------------------------------------------------------------------------DVFDRS-LTEKELVSQSKALCRDYILSRLHQNGQGWSK D_rerio_ENSDARP00000090569 ----------------------------------------------------------------------------------DVFDRT-HTEKELVFQSKELCRDFIHSRITREGLSWSK T_rubripes_ENSTRUP00000018728 ----------------------------------------------------------------------------------DVFDRS-LTEKELVSHSKALCRDYILSRLNQNGLGCSK O_latipes_ENSORLP00000020538 ----------------------------------------------------------------------------------DVFERS-LSEKELVTQSKALCRDYILSRLHQNGMGWSK A_aegypti_AAEL001515-PA ----------------------------------------------------------------------------------SPIHHL-TTTQDVINQGKCLCGEYIRARLRRSGLLNRK A_gambiae_AGAP011552-PA ----------------------------------------------------------------------------------SPIHHL-TTSQDVINQGKCLCGEYIRARLKRSGLLNRK A_aegypti_AAEL001521-PA ----------------------------------------------------------------------------------GWKQPV-LPSQDIITQGKCLCGQYIRCRLKKSGVFNRK D_melanogaster_FBpp0085443 ----------------------------------------------------------------------------------TMTNYQ-EYKMDIINQGKCLCGQYIRARLRRAGVLNRK D_melanogaster_FBpp0087182 ----------------------------------------------------------------------------------GWKAAQ-IPAQDIISQGRCLCGHYIKRRLRRSGLFNKK C_intestinalis_ENSCINP00000019812 ----------------------------------------------------------------------------------DSVFNS-TSYEEDVRLTTGICRDYICYRLKRDGFGER- C_intestinalis_ENSCINP00000016140 STPANQTGTPKRRSGIASFATGSSPRNLWQPQKPSVRFTDVNDSNINAATPPDMSSRSFRNRRATVHYSSTGRPSVMERRHPARIALE-AKEGKALEQTKDICKDYIVHRLQQRKLANR- D_rerio_ENSDARP00000089067 ----------------------------------------------------------------------------------ATGGED-VVDDAIIEQSAVLLRGYVIQQATI------- D_rerio_ENSDARP00000095258 ----------------------------------------------------------------------------------------------MSYYNRELVVFFIKYKLSQRNYPCNH G_aculeatus_ENSGACP00000018700 ----------------------------------------------------------------------------------PGGGDQGNNKDQILELGTVLLKDFIFERVKR------- G_aculeatus_ENSGACP00000018978 ----------------------------------------------------------------------------------AEGGED-VVDDPIMEQGAVVLRGYVVSRINA------- T_rubripes_ENSTRUP00000014135 ----------------------------------------------------------------------------------------------MS-QNRELVIFYIKYKLSQRNYPFNH G_aculeatus_ENSGACP00000005643 ----------------------------------------------------------------------------------------------MS-QNRELVVFYINYKLSQRNLPLNH T_nigroviridis_ENSTNIP00000007577 ------------------------------------------------------------------------------RSHPGAKSKG-ASTQRMS-LNRELVIFYIKYKLSQRNYPLSH T_rubripes_ENSTRUP00000012873 ------------------------------------------------------------------------------------------QVGMERECNRDIVENYICHKLSKRGFAWSF M_domestica_ENSMODP00000017160 ----------------------------------------------------------------------------------RGGAGA-TSSEQIMRTGAVLLQGFIQDRAGR------- T_guttata_ENSTGUP00000006866 ----------------------------------------------------------------------------------------------MYSSNRELVIDFVSYKLSQKGYSWSQ X_tropicalis_ENSXETP00000052058 ---------------------------------------------------------------------------------------M-AHPRRGGYDHRDIVVKYIHYKLSQKGYEWEE H_sapiens_ENSP00000293288 -----------------------------------------------------------------------------------RGGGP-TSSEQIMKTGALLLQGFIQDRAGR------- B_taurus_ENSBTAP00000000549 -----------------------------------------------------------------------------------------TSEEQVARDTEEVFRSYVFYRHQQ------- O_latipes_ENSORLP00000021005 ---------------------------------------------------------------------------------------------MANVSNRSIVEKYICHKLSKRGYVCGL G_aculeatus_ENSGACP00000013488 ----------------------------------------------------------------------------------------------MANINRELVEFFLSYKLSQKNHPTSL A_carolinensis_ENSACAP00000011187 ----------------------------------------------------------------------------------------------MSSSNRALVVDFLSYKLSQRGHSWHE O_latipes_ENSORLP00000017513 ------------------------------------------------------------------------------------------QAHTMSHCNRELVRFYLAYKMSCRDYPVSL T_rubripes_ENSTRUP00000032199 ----------------------------------------------------------------------------------------------MSYNNRELVEHFLRYKLSQRNYPTSL R_norvegicus_ENSRNOP00000040259 ----------------------------------------------------------------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQ E_caballus_ENSECAP00000014770 ----------------------------------------------------------------------------------------------MSQSNRELVVDFLSYKLSQKGYNWSQ X_tropicalis_ENSXETP00000031936 ----------------------------------------------------------------------------------KYLTEQ-GWMAQSELGSRALVEDFVRYKLCQRSLV--- X_tropicalis_ENSXETP00000050759 ----------------------------------------------------------------------------------DRSGTG-VSTEQILETGELLLNGFISDRLQNNP----- B_taurus_ENSBTAP00000008572 ----------------------------------------------------------------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQ T_nigroviridis_ENSTNIP00000017211 ---------------------------------------------------------------------------------------D-VVDDPILEQGAVVLRGYVIERIHV------- M_mulatta_ENSMMUP00000005209 -----------------------------------------------------------------------------------RGGGP-TSSEQIMKTGALLLQGFIQDRAGR------- M_musculus_ENSMUSP00000086454 ----------------------------------------------------------------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQ P_troglodytes_ENSPTRP00000019323 -----------------------------------------------------------------------------------RGGGP-TSSEQIMKTGALLLQGFIQDRAGR------- M_mulatta_ENSMMUP00000007865 ----------------------------------------------------------------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQ C_familiaris_ENSCAFP00000010478 ----------------------------------------------------------------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQ H_sapiens_ENSP00000365230 ----------------------------------------------------------------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQ P_pygmaeus_ENSPPYP00000012163 ----------------------------------------------------------------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQ P_troglodytes_ENSPTRP00000022903 ----------------------------------------------------------------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQ G_gallus_ENSGALP00000010059 ----------------------------------------------------------------------------------------------MSSSNRELVIDFVSYKLSQRGHCWSE X_tropicalis_ENSXETP00000053903 ----------------------------------------------------------------------------------------------MEGSSRDLVEKFVCKKLSQKGACGEF M_domestica_ENSMODP00000024313 ----------------------------------------------------------------------------------------------MSHSNRELVIDFLSYKLSQKGYNWSQ A_carolinensis_ENSACAP00000017311 ---------------------------------------------------------------------------------------M-AHPGIRGYDNREIVLRYIHYKLSQKGYDWVA D_rerio_ENSDARP00000023687 ----------------------------------------------------------------------------------SGGGDTGSGNDQILDLGAALLNNFVYERVRR------- T_nigroviridis_ENSTNIP00000002788 ---------------------------------------------------------------------------------------------MAREYNRDIVEKYIFHKLSKRGFVWRF D_rerio_ENSDARP00000096467 ------------------------------------------------------------------------------------------MANEISYDNRNIVEKYLKHKLSKRGYVWKC O_cuniculus_ENSOCUP00000002775 ----------------------------------------------------------------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQ B_taurus_ENSBTAP00000017739 -----------------------------------------------------------------------------------RGGGP-TSSEQIMKTGALLLQGFIQDRAGR------- T_nigroviridis_ENSTNIP00000013781 ----------------------------------------------------------------------------------------------MSHTNRELVEFYLNYKLSHSNFLTSL O_anatinus_ENSOANP00000014671 -----------------------------------------------------------------------------------AAPRMATPAPASVSDTRALVADFVGYKLRQKGF---- R_norvegicus_ENSRNOP00000003768 -----------------------------------------------------------------------------------------AQAGRTGYDNREIVMKYIHYKLSQRGYEWDT G_aculeatus_ENSGACP00000017662 ---------------------------------------------------------------------------------------------MSNECNRHIVEKYICHKLSKRGYAFGF A_carolinensis_ENSACAP00000016202 ------------------------------------------------------------------------------------------AEDQVAQETEEVFQSYAFYRYQQ------- M_musculus_ENSMUSP00000022806 -----------------------------------------------------------------------------------------MATPASTPDTRALVADFVGYKLRQKGYV--- T_rubripes_ENSTRUP00000036334 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000021385 -----------------------------------------------------------------------------------------TSEEQVARDTEEVFRSYVYYRHQQ------- O_latipes_ENSORLP00000005745 ----------------------------------------------------------------------------------PGGGDQ-EKSKELLDVGTKLLKNFICERVRR------- M_domestica_ENSMODP00000005598 -----------------------------------------------------------------------------------------MATPASAPDTRALVADFVGYKLRQKGYA--- T_nigroviridis_ENSTNIP00000010122 ----------------------------------------------------------------------------------------------MSYDNRELVEYFLGYKLAQRNYPSSL R_norvegicus_ENSRNOP00000028328 -----------------------------------------------------------------------------------GGGGP-TSSEQIMKTGAFLLQGFIQDRAER------- O_cuniculus_ENSOCUP00000005553 -----------------------------------------------------------------------------------RGGGP-TSSEQIMKTGALLLQGFIQDRASR------- G_gorilla_ENSGGOP00000001415 -----------------------------------------------------------------------------------------MATPASAPDTRALVADFVGYKLRQKGYV--- M_mulatta_ENSMMUP00000019355 -----------------------------------------------------------------------------------------MATPASAPDTRALVADFVGYKLRQKGYV--- M_musculus_ENSMUSP00000033093 -----------------------------------------------------------------------------------GSGGP-TSSEQIMKTGAFLLQGFIQDRAGR------- A_carolinensis_ENSACAP00000017228 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250405 -----------------------------------------------------------------------------------------MATPASAPDTRALVADFVGYKLRQKGYV--- O_cuniculus_ENSOCUP00000002204 --------------------------------------------------------------------------------------------QQVARDTEEVFRSYVFHRHRQ------- B_taurus_ENSBTAP00000026248 -----------------------------------------------------------------------------------------MATPASAPDTRALVADFVGYKLRQKGYV--- E_caballus_ENSECAP00000008404 -----------------------------------------------------------------------------------------MATPASAPDTRALVADFVGYKLRQKGYV--- P_troglodytes_ENSPTRP00000010457 -----------------------------------------------------------------------------------------MATPASAPDTRALVADFVGYKLRQKGYV--- T_guttata_ENSTGUP00000002093 -----------------------------------------------------------------------------------------AHPGRRGYDNREIVLKYIHYKLSQRGYDWAA M_musculus_ENSMUSP00000077757 -----------------------------------------------------------------------------------------PSEQQVAQDTEEVFRSYVFYLHQQ------- G_gallus_ENSGALP00000020984 -----------------------------------------------------------------------------------------AHPGRRGYDNREIVLKYIHYKLSQRGYDWAA X_tropicalis_ENSXETP00000056677 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000015983 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000000576 -----------------------------------------------------------------------------------------ASEQQVAQDTEEVFRSYVFYLHQQ------- M_domestica_ENSMODP00000023449 ---------------------------------GAADVPMCPEEELDGYEPEPPGKRPSRLAVLEIAREGGDSPNGSLPSTPPPAEED-EEEDELYGQSLELISRYLREQA--------- E_caballus_ENSECAP00000017850 -----------------------------------------------------------------------------------------AHAGRTGYDNREIVMKYIHYKLSQRGYEWDA M_musculus_ENSMUSP00000108371 -----------------------------------------------------------------------------------------AQAGRTGYDNREIVMKYIHYKLSQRGYEWDA G_gallus_ENSGALP00000039057 ------------------------------------------------------------------------------------PSREINAEDQVAQETEEVFRSYTFYRYQQ------- R_norvegicus_ENSRNOP00000056470 -------------------------------------------------------------------------------------------IPVSTPDTWALVADFVGYKL--------- C_familiaris_ENSCAFP00000000102 -----------------------------------------------------------------------------------------AHAGRTGYDNREIVMKYIHYKLSQRGYEWDA G_gorilla_ENSGGOP00000010113 -----------------------------------------------------------------------------------RGGGP-TSSEQIMKTGALLLXXXXXXXXXX------- 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000314132 PER--------------------------------------------------------AAPVP-GRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHISLQSE----PVVTDAFLAVA- G_gorilla_ENSGGOP00000015296 PER--------------------------------------------------------AAPVP-GRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHISLQSE----PVVTDAFLAVA- M_mulatta_ENSMMUP00000007481 PER--------------------------------------------------------AAPVP-GRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHISLQSE----PVVTDAFLAVA- P_pygmaeus_ENSPPYP00000014939 PER--------------------------------------------------------AAPVP-GRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHISLQSE----PVVTDAFLAVA- M_musculus_ENSMUSP00000027499 PER--------------------------------------------------------ASPAPGGRLAEVCTVLLRLGDELEQIRPSVYRNVARQLHIPLQSE----PVVTDAFLAVA- R_norvegicus_ENSRNOP00000024693 PER--------------------------------------------------------ASPAPGGRLAEVCTVLLRLGDELEQIRPSVYRNVARQLHIPLQSE----PVVTDAFLAVA- B_taurus_ENSBTAP00000011478 PER--------------------------------------------------------AAPVPGGRLAEVCAVLLRLADELELIRPSVYRNVARQLNLSLQSE----TVVTDAFLAVA- M_domestica_ENSMODP00000020066 PEA--------------------------------------------------------KTPTPGGKLAEVASILLRLGDELEYIRPNVYRNIARQLNISLQSE----SVVTDAFLAVA- T_guttata_ENSTGUP00000006267 PEY--------------------------------------------------------NAPVPGGKLAEVSTILLRLGDELEYIRPNVYRNIARQLNISLHSE----TVVSDAFLAVA- O_anatinus_ENSOANP00000008963 PDY--------------------------------------------------------NVPSPGGKLAEVSTILLRLGDELEYIRPNVYRNIARQLNISLHSE----TVVTDAFLAVA- A_carolinensis_ENSACAP00000000851 PEH--------------------------------------------------------SVPVPGGKLAEVSNILLRLGDELEYIRPNLYRNVARQLNISLHSE----TVVTDAFLAVA- G_gallus_ENSGALP00000009257 PEH--------------------------------------------------------NTPVPGGKLAEVSAILLCLGDELEYIRPNVYRNIARQLNISLHSE----TVVTDAFLAVA- D_rerio_ENSDARP00000068408 PEH--------------------------------------------------------G---SGGTLAEVSSVLLWLGDELEYLRPNVYRNVARQLNITIASE----NIVSDAFLAVA- G_aculeatus_ENSGACP00000006084 PES--------------------------------------------------------GRAAPGGGLGDVSSALLWLGDELEYLRPNVYRNVARQLNITVASE----SIVSDAFLAVA- T_nigroviridis_ENSTNIP00000005841 AEN--------------------------------------------------------GPPASGGTLGEASAVLLWLGDELEHLRPNVYCNVARQLNITVASE----SIMSDAFLAVA- T_rubripes_ENSTRUP00000030263 ADH--------------------------------------------------------GLAASGGTLGEVSSVLMWLGAELEYLRPNVYCNVARQLNITVASE----SIMSDAFLAVA- O_latipes_ENSORLP00000002641 PEH--------------------------------------------------------AQAGAGGALGEVSSVLLWLGEELEYLRPNVYRNVARQLNITVASE----SIVSDAFLAVA- E_caballus_ENSECAP00000000132 -------------------------------------------------------------------------------DELELIRPSVYRNVARQLNISLQSE----TVVTDAFLAVS- T_nigroviridis_ENSTNIP00000018321 SEL--------------------------------------------------------NLSPSSTALADASMVLLCLGDELESMQPSLYRNVARQLNISVAME----NMVSDAFIAVA- G_aculeatus_ENSGACP00000018053 TEL--------------------------------------------------------HLSPSSAALAEVSLVLLCLGDELESIRPSLYRNVARQLNISVAME----NMVSDAFIGVA- D_rerio_ENSDARP00000090569 VEL--------------------------------------------------------DLPEPRGVLVDVSVVLLKLGDELECMRPYVYRNIAKQLNISVSVE----AVVSDAFLSVA- T_rubripes_ENSTRUP00000018728 AEL--------------------------------------------------------NLSPSSAALADASMVLLCLGDELESMQPSLYRNVARQLNISVAME----NMVSDAFIGVA- O_latipes_ENSORLP00000020538 AEI--------------------------------------------------------NFSPSNAALSEVTMVLLCLGDELECIQPGLYRNVARQLNISVAME----NVVSDAFLGVA- A_aegypti_AAEL001515-PA ------------------------------------------I-LQRLRSTME--------VPNCVVVRETSPILNGMGEELERMHPRLYTNVSRQISVEPWGELTEPDSVCYLLHIVA- A_gambiae_AGAP011552-PA ------------------------------------------I-LQRLRNSMEHCMAGSGGLGGGAVVREALPILNGMGEELERMHPRLYSNVSRQISNEPWGELTEPDTVGYLLHVVA- A_aegypti_AAEL001521-PA ------------------------------------------LGLQRIRSIVG--------TPTIHVVREVFPALLSVGEELERMYPRVYNGVARQLSRIGRGELKTPETAPVLLSAIA- D_melanogaster_FBpp0085443 ------------------------------------------V-TQRLRNILD--------PGSSHVVYEVFPALNSMGEELERMHPRVYTNISRQLSRAPFGELEDSDMAPMLLNLVA- D_melanogaster_FBpp0087182 ------------------------------------------LGLQRIRSILG--------STSMGIVRDVFPAVQVLGDELERMHPRIYNGVARQICRNPGGEFHTPDAVSLLLGAVG- C_intestinalis_ENSCINP00000019812 ------------------------------------------VTVTEHAPAHN---------------HNLSNKILNLGSGFERMFPKSFRQISRQIGYVFSSE----ATVRRLYFRMG- C_intestinalis_ENSCINP00000016140 ------------------------------------------VKVTRQQSAS----------------RALSRDVIFIASELERMQKHLYSDVSKQIGITLRSE----DVLRKVFFELA- D_rerio_ENSDARP00000089067 --------------------------------------------DDPNIHVSHETLGGRPQDEEDPQIKEVVDQLLKIADDLNKNAE--LQHLISTVQS---------NCAQDVFMTVA- D_rerio_ENSDARP00000095258 IGL-TEDTN---RTDGA---EENG-EGAAGATTLVNGTMNRTNASSTGTPPQSPASSPQRQTNGSGGLDAVKEALRDSANEFELRYSRAFNDLSSQLHITP-------ATAYQSFESVM- G_aculeatus_ENSGACP00000018700 -------------------------------------------HGDSTETVTRTQLGGV--ELSDPNHKKLAMCLQQIGDELDGNVE--LQRMMNDSSL---------GPTKDVFLKVA- G_aculeatus_ENSGACP00000018978 --------------------------------------------EDPSRHVSPEQLGGRPNEHQDPQIKEVVKQLMKIADEMNRNAE--LQRLISQVPG---------NCAQDIFMKVA- T_rubripes_ENSTRUP00000014135 NGLILEPPS---RTDG------------QFVTTQFNGTF---NGASPGTPPATSL---------ATSLDTVKEALRDTGNEFELRYTCAFSDLHNQLHITP-------ATAYQSFENVM- G_aculeatus_ENSGACP00000005643 IGL-SEPPN---RTGGG---VEAGAAGGQRGATHSNGTF---NGTSPGTPPASPL--LQQRSPSTASLDAVKEALRDSANEFELRYARAFSDLHNQLHITP-------ATAYQSFEDVM- T_nigroviridis_ENSTNIP00000007577 I---VEPSS---RTEG------------QFGTTQSNGTF---NGASPGTPPAPSQ-----HQQSLTSLDAVKEALRDTGNEFELRYTCAFSDLHNQLHITP-------ATAYQSFENVM- T_rubripes_ENSTRUP00000012873 EDV-QDENA---ANNGS-----------VVAPAPTLVRRCHEAGTGPDRDRGSISHPCKEPP-ASDQHAAIHRVLREAGDELERLYQPDFTEMSRQLYLSS-------TTAQRRFAEVI- M_domestica_ENSMODP00000017160 -------------------------------------------VAGGAPELLLDSMGDSAPLPSDPRTKRLTECLRRIGDELDSNME--LQRMIAAVET---------DSPREVFFRVA- T_guttata_ENSTGUP00000006866 LEEEDENRT---DFAGE----------EDEMDGVLNGSPSWHAATSHIVNGATVHQNSL-EVHEIRRAADVRQALREAGDEFELRYRRAFSDLTSQLHITP-------STAYQSFEQVV- X_tropicalis_ENSXETP00000052058 GRQQVSAEH---PQASAAISNYSDDGEMPAASADS-------RGPPQSSLASAAASSDEETPTMQPVPPAVLQTLSRAGDEFSRLYQQDFRQISGLLHLTP-------STVRVRFATVV- H_sapiens_ENSP00000293288 -------------------------------------------MGGEAPELALDP------VPQDASTKKLSECLKRIGDELDSNME--LQRMIAAVDT---------DSPREVFFRVA- B_taurus_ENSBTAP00000000549 ------------------------------------------EQEAEGAAAPTDPEMVTLHPEPSSTMGQVGRQLAVIGDDINRRYDAEFQAMLQHLQPTA-------DNAYEYFTKIA- O_latipes_ENSORLP00000021005 NGG-QRENA---ANNGS-----------VGDHSPT----------------------------PADPLADIHRVLREAGDELERLYQRDFTEMSRQLYLTS-------TTAKTRFAEVI- G_aculeatus_ENSGACP00000013488 LRP-EDAGG---RTEGD-----------KANSASVPG-----RGSSAGQPGMSSP-----PPPPSGDTEAVKAALQDSANEFELLFTQAFSDLSLQLDVTP-------DTAYHSFKSVM- A_carolinensis_ENSACAP00000011187 IEM--ESGE---EAM----------EPANETGNTLNGSPSWHPSPSHVINGASEHPELLEEEEEENPRVDVSQTLREAGDEFELRYRRAFSDLTSQLHITL-------GTAYQSFEQVV- O_latipes_ENSORLP00000017513 LKP-TDDGG---ETEED------------------------HSDARNRRLVSSEDGRLRRSCPCCASMDAIKSTLKDSADEFERRFHQGFSDLSVQLHITP-------DTAYQNFKRVL- T_rubripes_ENSTRUP00000032199 LRP-EDTDG---RTEGE-----------KRSPGASNGLLVRSRNRGGA------------SPSAGAGIEAVNAALRDSAEEFEKLFAQAFSDLSSQLDITP-------DTAYQSFKNVM- R_norvegicus_ENSRNOP00000040259 FSDVEENRT---EAPEE-------TEPERETPSAINGNPSWHLADSPAVNGATGHSSSL-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQVV- E_caballus_ENSECAP00000014770 FSDVEENRT---EAPEG-------TESEMETPSAINGNPSWHLADSPTGNGATGHSSSL-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQVV- X_tropicalis_ENSXETP00000031936 ---------------------------------------------PEPAGAAS---------------CSLHSAMRAAGDEFEERFRQAFSEISTQIHVTP-------GTAYARFAEVA- X_tropicalis_ENSXETP00000050759 ------------------------------------------DVAGARALFPGST------QHSDPSIKRLSECLRKIGDELDANIE--LQRRIECVPC---------NSPKQVFFHVA- B_taurus_ENSBTAP00000008572 FSDVEENRT---EAPEG-------TESDMETPSAINGNASWHLADSPAVNGATGHSRSS-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQVV- T_nigroviridis_ENSTNIP00000017211 --------------------------------------------EQPSLHVSSEDLGGRSEEQRDPQTKEVVEQLLKIADDLNRNAE--FQHLVSQVQG---------NCAQDVFMQVA- M_mulatta_ENSMMUP00000005209 -------------------------------------------MGGETPELALDP------VPQDASTKRLSECLKRIGDELDSNME--LQRMIAAVDT---------DSPREVFFRVA- M_musculus_ENSMUSP00000086454 FSDVEENRT---EAPEE-------TEAERETPSAINGNPSWHLADSPAVNGATGHSSSL-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQVV- P_troglodytes_ENSPTRP00000019323 -------------------------------------------MRGEAPELALDP------VPQDASTKKLSECLKRIGDELDSNME--LQRMIAAVDT---------DSPREVFFRVA- M_mulatta_ENSMMUP00000007865 FSDVEENRT---EAPEG-------TESEMETPSAINGNPSWHLVDSPAVNGATGHSSSL-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQVV- C_familiaris_ENSCAFP00000010478 FSDVEENRT---EAPEG-------TESEMETPSAINGNPSWHLADSPAVNGATGHSSSL-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQVV- H_sapiens_ENSP00000365230 FSDVEENRT---EAPEG-------TESEMETPSAINGNPSWHLADSPAVNGATGHSSSL-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQVV- P_pygmaeus_ENSPPYP00000012163 FSDVEENRT---EAPEG-------TESEMETPSAINGNPSWHLADSPAVNGATGHSSSL-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQVV- P_troglodytes_ENSPTRP00000022903 FSDVEENRT---EAPEG-------TESEMETPSAINGNPSWHLADSPAVNGATGHSSSL-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQVV- G_gallus_ENSGALP00000010059 LEEEDENRT---DTAAE-----------AEMDSVLNGSPSWHPPAGHVVNGATVHRSSL-EVHEIVRASDVRQALRDAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQVV- X_tropicalis_ENSXETP00000053903 SSN-SQPKG---VSNGS---------------------------------------SEGPGATQGIVGEEVLQALLDASEEFELRYQRAFSDLTAQLHLTQ-------DTAQQSFQQVV- M_domestica_ENSMODP00000024313 FED--ENRT---EVLEG-----------AEIPSTVNGSPSWHPADSRAVSGATGHSSSL-DAHETIPVAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQVV- A_carolinensis_ENSACAP00000017311 SGDRGNLAA---AAAAA---AAT-----PSAPTVS-------ASLSPELLNSDPVSTNAPREEPDPVPQVVHTTLRQAGDEFSRRYRRDFAQMSGQLHLTP-------STARSRFVAVV- D_rerio_ENSDARP00000023687 -------------------------------------------HGDRDAEVTRSQLGGV--ELCDPSHKRLAQCLQQIGDELDGNAQ--LQSMLNNSNL---------QPTQDVFIRVA- T_nigroviridis_ENSTNIP00000002788 EEV-QDQNA---ANNGS-----------VVAPAPTLVRRCHEAGTGP--DRGSIPHLCKRTP-QSEQHAAIHRVLREAGDELERLYQPDFTEMSRQLYLTS-------TTAQRRFAEVI- D_rerio_ENSDARP00000096467 QSS-AEEDD---TFNKA-----------VEESSPNSDR----RLQAPSAGGGNNSECLIARVTRSDPHLRLYRVLRDAGDEIERIYQREFEEMSQQMVFNP-------NSAQRSFLTVA- O_cuniculus_ENSOCUP00000002775 FSDVEENRT---EAPEG-------TGPEMETPSAINGNPAWHPADSPAVNGATGHSSSL-DAREVIPMTAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQVV- B_taurus_ENSBTAP00000017739 -------------------------------------------MGGETPELGLEQ------VPQDASTKKLSECLKRIGDELDSNME--LQRMIAAVDT---------DSPREVFFRVA- T_nigroviridis_ENSTNIP00000013781 RAS-------------------------ADAWQSPRISRRDRSGASPSSDAGR---------------RAVKAVLRKATDDFEKKLTRACGDLSS--YLPS-------KISHQNFNNTM- O_anatinus_ENSOANP00000014671 ----------------------------------------------------A---------------QPLHRAMRAAGDEFESRFRRAFSDLASQLHVTP-------GSAQQRFTQVS- R_norvegicus_ENSRNOP00000003768 GDEDSAPLR---AAPTPGIFSFQ-----PESNRTPAVHRDTAARTSPLRPLVA---TAGPA--LSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTP-------FTARGRFATVV- G_aculeatus_ENSGACP00000017662 DDV-GEEDA---ASNGS-----------MVVPPPTAVRRCREAGP----DGESFPRLCKRLPQSDPTAAATHRVLREAGDELERLYQPDFTEMSRQLYLTS-------TTAQRRFAEVI- A_carolinensis_ENSACAP00000016202 ------------------------------------------EREQTEGDVPHDPEIAAIPHEPNSTNCQVGRRLATIGDDINARYDKEFSEMLKSLQPTK-------DNAYEYFIRIA- M_musculus_ENSMUSP00000022806 ------------------------------------------CGAGPGEGPAA---------------DPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTP-------GSAQQRFTQVS- T_rubripes_ENSTRUP00000036334 ---------------------------------------------------------------SDPNHKKLAQCLQKIGDELDGNME--LQRMINDSAL---------KPTKDMFMKVA- E_caballus_ENSECAP00000021385 ------------------------------------------EQEAEGAAAPADPEMDTLPLEPNSTMGQVGRQLAIIGDDINRRYDSEFQTMLKHLQPTA-------ENAYELFTKIA- O_latipes_ENSORLP00000005745 -------------------------------------------NLQDDSEVVRQQLGAE--ELVDPNHKRLAQCLQQIGDELDGNVE--LKRLIDDSSL---------SPSKEVFLKVA- M_domestica_ENSMODP00000005598 ------------------------------------------CGTGPGEGPTT---------------EPLHRAMRAAGDEFESRFRRTFSDLAAQLHVTP-------GSAQQRFTQVS- T_nigroviridis_ENSTNIP00000010122 LRP-QEPDG---WTEGD-----------KKSPAAVNGLLIRNRSRSGA------------SASTGAGVEAVHAALRDSAEEFEKLFAQAFSDLSSQLVITP-------DTAYQSFKNVM- R_norvegicus_ENSRNOP00000028328 -------------------------------------------MAGETPELTLEQ------PPQDASTKKLSECLRRIGDELDNNME--LQRMIADVDT---------DSPREVFFRVA- O_cuniculus_ENSOCUP00000005553 -------------------------------------------MGGQTPELAVAQ------GPQDESTKKLSECLKRIGDELDSNME--LQRMIAAVDT---------DSPREVFFRVA- G_gorilla_ENSGGOP00000001415 ------------------------------------------CGAGPGEGPAA---------------DPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTP-------GSAQQRFTQVS- M_mulatta_ENSMMUP00000019355 ------------------------------------------CGAGPGEGPAA---------------DPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTP-------GSAQQRFTQVS- M_musculus_ENSMUSP00000033093 -------------------------------------------MAGETPELTLEQ------PPQDASTKKLSECLRRIGDELDSNME--LQRMIADVDT---------DSPREVFFRVA- A_carolinensis_ENSACAP00000017228 ----------------------------------------------------------------DPKTKQLSECLRRIGDELDGNME--LQSMIEQVQV---------YPPKEVFFRVA- H_sapiens_ENSP00000250405 ------------------------------------------CGAGPGEGPAA---------------DPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTP-------GSAQQRFTQVS- O_cuniculus_ENSOCUP00000002204 ------------------------------------------EQEAEGAAAPADPEMISLHLEPNSTMGQVGRQLAIIGDDINQRYDSDFQNMLEKLQPTA-------ENAYELFTKIAL B_taurus_ENSBTAP00000026248 ------------------------------------------CGAGPGEGPAA---------------DPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTP-------GSAQQRFTQVS- E_caballus_ENSECAP00000008404 ------------------------------------------CGAGPGEGPAA---------------DPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTP-------GSAQQRFTQVS- P_troglodytes_ENSPTRP00000010457 ------------------------------------------CGAGPGEGPAA---------------DPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTP-------GSAQQRFTQVS- T_guttata_ENSTGUP00000002093 GEDRASLPPDHSASAAAAIAAAA-----IAAAGTSDHTGL--VSPHPEPPGSATASHTPPAEGLRPAPQAVHLVLRQAGDEFSRRYQRDFSQMSGQLHLTP-------FTARSRFVAVV- M_musculus_ENSMUSP00000077757 ------------------------------------------EQETQGAAAPANPEMDNLPLEPNSILGQVGRQLALIGDDINRRYDTEFQNLLEQLQPTA-------GNAYELFTKIA- G_gallus_ENSGALP00000020984 GEDRPPVPP----APAPAAAPAA-----VAAAGAS-------SHHRPEPPGSAAASEVPPAEGLRPAPPGVHLALRQAGDEFSRRYQRDFAQMSGQLHLTP-------FTAHGRFVAVV- X_tropicalis_ENSXETP00000056677 -----------------------------------------------------------------XNLISVGQQLAKIGDDINERYQEQFDDILKHLNPSL-------DNAYSYFKKIA- T_guttata_ENSTGUP00000015983 -----------------------------------------------------EP------QPSSPDTKRLSECLRRIGDELDSNME--LQRMIEQVGC---------DAPKKLFFRVA- R_norvegicus_ENSRNOP00000000576 ------------------------------------------EQETQGAAAPANPEMDNLSLEPNSVLGQVGRQLALIGDDINRRYDTEFQNLLEQLQPTA-------GNAYELFTKIA- M_domestica_ENSMODP00000023449 ------------------------------------------VGTKEAKPLRS---------------GKALETLRRVGDGVQRNHERAFQGMLRKLDIKN-------EEDIKAVSRVA- E_caballus_ENSECAP00000017850 GDAGAAPLG---ATPVPGIFSSQ-----PGRTPAP-------ARTSPLLPPAAPAGAAGPA--LSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTP-------FTARGRFATVV- M_musculus_ENSMUSP00000108371 GDADAAPLG---AAPTPGIFSFQ-----PESNPMPAVHRDMAARTSPLRPLVA---TAGPA--LSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTP-------FTARGRFATVV- G_gallus_ENSGALP00000039057 ------------------------------------------EREEGGAEVPMDPEIMEIQQELGSTGSQVGRRLAIIGDDINKRYDAEFRHMLKSLQPTK-------ENAYEYFTTIA- R_norvegicus_ENSRNOP00000056470 ------------------------------------------SGAGPGKGPAA---------------DLLHQAMHAAGDEFETRFRYTFSDLATQQHVTP-------GSAQQRFTQVS- C_familiaris_ENSCAFP00000000102 GEAGAAPPG---AAPAPGISAS-----------------------------------------XSPVPPVVHLTLRQAGDDFSRRYRR-FAEMSSQLHLTP-------FTARGRFATVV- G_gorilla_ENSGGOP00000010113 -------------------------------------------XXXXXXXXXXXX------XXXXXSTKKLSECLKRIGDELDSNME--LQRMIAAVDT---------DSPREVFFRVA- 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000314132 -GHIFSA------------G-------------------ITWGKVVSLYAVAAGLAVDCV-RQAQPAMVHALVDCLGEF-VRKTLATWLRRRGGW---------TDVLK----------- G_gorilla_ENSGGOP00000015296 -GHIFSA------------G-------------------ITWGKVVSLYAVAAGLAVDCV-RQAQPAMVHALVDCLGEF-VRKTLATWLRRRGGW---------TDVLK----------- M_mulatta_ENSMMUP00000007481 -GHIFSA------------G-------------------ITWGKVVSLYAVAAGLAVDCV-RQAQPAMVHALVDCLGEF-VRKTLATWLRRRGGW---------TDVLK----------- P_pygmaeus_ENSPPYP00000014939 -GHIFSA------------G-------------------ITWGKVVSLYAVAAGLAVDCV-RQAQPAMVHALVDCLGEF-VRKTLATWLRRRGGW---------TDVLK----------- M_musculus_ENSMUSP00000027499 -GHIFSA------------G-------------------ITWGKVVSLYSVAAGLAVDCV-RQAQPAMVHALVDCLGEF-VRKTLATWLRRRGGW---------TDVLK----------- R_norvegicus_ENSRNOP00000024693 -GHIFSA------------G-------------------ITWGKVVSLYSVAAGLAVDCV-RQAQPAMVHALVDCLGEF-VRKTLATWLRRRGGW---------TDVLK----------- B_taurus_ENSBTAP00000011478 -TQIFSA------------G-------------------ITWGKVVSLYSVAAGLAVDCV-RQAQPALVHALVDCLGEF-VRKTLATWLRRRGGW---------TDVLK----------- M_domestica_ENSMODP00000020066 -TQIFAA------------G-------------------ITWGKVVSLYAVAAGLAVDCV-KQAQPAMVHTIVDCLGEF-VRKTLVTWLKRRGGW---------ADIMK----------- T_guttata_ENSTGUP00000006267 -TQIFSA------------G-------------------ITWGKVVSLYAVAAGLAVDCV-RHAQPAMVHTIVDCLGEF-VRKTLVTWLKRRGGW---------ADITK----------- O_anatinus_ENSOANP00000008963 -TQIFSA------------G-------------------ITWGKVVSLYAVAAGLAVDCV-KQGQPAMVHTIVDCLGEF-VRKTLVTWLKRRGGW---------ADIMK----------- A_carolinensis_ENSACAP00000000851 -TQIFSS------------G-------------------ITWGKIVSLYAVAAGLAVDCV-RHAQPAMVHTIVDCLGEF-VRKTLVTWMKRRGGW---------SDITK----------- G_gallus_ENSGALP00000009257 -AQIFTA------------G-------------------ITWGKVVSLYAVAAGLAVDCV-RHAQPAMVHTIVDCLGEF-VRKTLVTWLKRRGGW---------ADITK----------- D_rerio_ENSDARP00000068408 -AEIFST-EYSRKGLEKHKG-------------------VTWGKIVSLYAVAGALAVDCV-RHGHPAMVHTIVDCMGEF-VRKSLASWLKKRGGW---------ADITK----------- G_aculeatus_ENSGACP00000006084 -ADIFST------------G-------------------VTWGKVVSLYAVAGALAVDCV-RHGHPAIVHTIVDCMGEF-VRKSLTTWLKRRGGW---------VDVTK----------- T_nigroviridis_ENSTNIP00000005841 -ADIFST------------G-------------------VTWGKVVSLYAVAGALAVDCV-RHGHPAMVHTIVDCMGEF-VRKSLTSWLKRRGGW---------VDVTR----------- T_rubripes_ENSTRUP00000030263 -ADIFST-EYILR--QRYEG-------------------VTWGKVVSLYAVAGALAVDCV-RHGHPAMIHTIVDCMGEF-VRKSLISWLKRRGGW---------VDVTK----------- O_latipes_ENSORLP00000002641 -ADIFSTGRISEKQNHCHKR-------------------ITWGKVVSLYAVAGALAVDCV-RHGHPAMVHTIVDCMGEF-ARKSLTVWLKKRGGW---------VDMTK----------- E_caballus_ENSECAP00000000132 -AQIF-A------------G-------------------ITWGKVVSLYLVAAGLAVDCV-RQAQPAMVHALVDCLGEF-VRKTLATWLRRRGGW---------TDVLK----------- T_nigroviridis_ENSTNIP00000018321 -TEILST------------G-------------------ITWGKVVSMYAVAGALAVDCV-RQGHPTTVHILVDSLGQF-VRRFLVPWLKRRGGW---------ADITR----------- G_aculeatus_ENSGACP00000018053 -TEIFST------------G-------------------ITWGKVVSMYAVAGALAVDCV-RQGHPATVHILVASLGQF-VRKFLVPWLKRRGGW---------AEMCK----------- D_rerio_ENSDARP00000090569 -TEVIAM-DYATNTVFDFKG-------------------ITWGKVVAIYAVAAGLAVDCV-RLGHPVMVHTIVDSLGEF-VRRSLVPWLKKRGGW---------VDILK----------- T_rubripes_ENSTRUP00000018728 -TEILST-GTNQRFLTKIQG-------------------ITWGKVVSMYAVAGALAVDCV-RQGHATTVHILVDSLGQF-VRKFLVPWLKRRGGW---------ADISR----------- O_latipes_ENSORLP00000020538 -TEIFSA-VFSAKTQQTDSI-------------------ITWGKVVSMYAVAGALAVDCV-RQGYLTTVHILVDSLGQF-VRKFLVHWLKRRGGW---------AEITK----------- A_aegypti_AAEL001515-PA -KDLFKT------------D-------------------ITWGKVISLFAIAGGLAVDCV-RQEHYDYLQQLIEGTTDV-IEEDLSLWLVEKGGW---------LGLHD----------- A_gambiae_AGAP011552-PA -KDLFKS------------G-------------------ITWGKVISLFAIAGGLAVDCV-RQDHADYLQQLIEGTADV-IEEDLSGWLVERGGW---------LGLQD----------- A_aegypti_AAEL001521-PA -RDLFRS------------D-------------------ITWGKVVSLFAIAGGLSVDCV-RQGHPDYLPKLIEGVADV-IEDELVTWISENGGW---------VGLAN----------- D_melanogaster_FBpp0085443 -KDLFRS------------S-------------------ITWGKIISIFAVCGGFAIDCV-RQGHFDYLQCLIDGLAEI-IEDDLVYWLIDNGGW---------LGLSR----------- D_melanogaster_FBpp0087182 -RELFRV------------E-------------------ITWSKVISLFAIAGGLSVDCV-RQGHPEYLPKLMESVSEV-IEDELVPWINENGGW---------SGINT----------- C_intestinalis_ENSCINP00000019812 -VHIMGV---------VECN-------------------YTWGRILSLLGLAGAMAVDCI-SQGHPELAESMIGISSDF-IQRNALDWIIKHGGW---------GGLVD----------- C_intestinalis_ENSCINP00000016140 -GEILTTEPVTIPKEATVNGETKKEKSRAFVSSGSRIIEITWGRICAVVAIAGGLSIDCV-NQGHSDLVNQLIEFCGEFASEEGVLRWIVSQGGW---------ETLRE----------- D_rerio_ENSDARP00000089067 -RSIFDD------------G-------------------INWGRVVALFHLAYRLIFQAL-TQNHLEIIKNIISWFLQF-MKKHISAWIRQQGGW---------EGIFR----------- D_rerio_ENSDARP00000095258 -DEVFRD------------G-------------------VNWGRIVGLFAFGGALCVECV-EKEMSPLVGRIAEWMTVY-LDNHIQPWIQSQGGW---------ERFAE----------- G_aculeatus_ENSGACP00000018700 -FEIFSD------------G------------------KFNWGRVVALFYFACRLVIKAL-VTKVPDIIRTIISWTMDY-LREHVINWIREQGGW---------EGIRS----------- G_aculeatus_ENSGACP00000018978 -KSIFDD------------G-------------------INWGRVVALFHLAYRLIYRAL-TTNHLENIRIIIGWVLRF-IRERLYPWLVQQGGW---------VGVIN----------- T_rubripes_ENSTRUP00000014135 -DEVFRD------------G-------------------VNWGRIVGLFAFGGALCVECV-EKEMSPLVGRIIEWMTVY-LDNHIQPWIQSQGGW---------VRFAE----------- G_aculeatus_ENSGACP00000005643 -DEVFRD------------G-------------------VNWGRIVGLFAFGGALCVECV-DKEMSPLVGRIVEWMTLY-LDNHIQPWIQNQGGW---------RSDI------------ T_nigroviridis_ENSTNIP00000007577 -DEVFRD------------G-------------------VNWGRIVGLFAFGGALCVECV-EKEMNPLVGRIIEWMTVY-LDNHIQPWIQSQGGW---------ERFAE----------- T_rubripes_ENSTRUP00000012873 -DELFRD------------G-------------------VNWGRIIAFFEFGGAVCAECAAKEEMSPQVDNIAEWMTEY-LNGSLNSWIQDNGGW---------QRALE----------- M_domestica_ENSMODP00000017160 -AEMFSD------------G------------------NFNWGRVVALFYFASKLVLKAL-CTKVPELIRTIVGWTLDF-LRERLLTWIQEQGGW---------V--------------- T_guttata_ENSTGUP00000006866 -NELFRD------------G-------------------VNWGRIVAFFSFGGALCVESV-VKEMRVLVKRIVSWMTTY-LTDHLDPWIQENGGW---------ERFVD----------- X_tropicalis_ENSXETP00000052058 -EELFHD------------G-------------------VNWGRIVAFFEFGGVMCVESV-NREMSPLVDSIVGWMTEY-LNSHLQNWIQEQGGW---------DAFVE----------- H_sapiens_ENSP00000293288 -ADMFSD------------G------------------NFNWGRVVALFYFASKLVLKAL-CTKVPELIRTIMGWTLDF-LRERLLGWIQDQGGW---------VRLLKPPHPHHRALTT B_taurus_ENSBTAP00000000549 -SSLFES------------G-------------------INWGRVVALLGFGYRLALHVY-QRGLTGFLGQVTRFVADFMLRRSIARWIAQRGGW---------VAALD----------- O_latipes_ENSORLP00000021005 -DELFRD------------G-------------------VNWGRIIAFFEFGGTVCVECASNEEMSTQVASIAEWMTEY-LNGPLNSWIEENGGW---------MCRLG----------- G_aculeatus_ENSGACP00000013488 -DEVFKD------------G-------------------VNWGRVVGLFAFGGVLCVECV-EKDMTELVSRIADWMTTY-LDEHISAWIQSQGGW---------DCFAD----------- A_carolinensis_ENSACAP00000011187 -NELFHD------------G-------------------VNWGRIVAFFSFGGALCVESV-DKEMQGLVVRIASWMTTY-LTEHLDPWIQENGGW---------ERFVD----------- O_latipes_ENSORLP00000017513 -DELFKD------------G-------------------INWGRVVGLFVFGGALCVECV-ERNMGELVSRIAEWMTQY-LDEQISPWIHSHGGW---------DCFAR----------- T_rubripes_ENSTRUP00000032199 -DEVFKD------------G-------------------VNWGRVVGLFAFGGVLCVECV-EKDASQLVCRIADWMTIY-LDEHINPWIQSQGGW---------DCFAK----------- R_norvegicus_ENSRNOP00000040259 -NELFRD------------G-------------------VNWGRIVAFFSFGGALCVESV-DKEMQVLVSRIASWMATY-LNDHLEPWIQENGGW---------VRTTP----------- E_caballus_ENSECAP00000014770 -NELFRD------------G-------------------VNWGRIVAFFSFGGALCVESV-DKEMQVLVSRIATWMATY-LNDHLEPWIQENGGW---------DTFVE----------- X_tropicalis_ENSXETP00000031936 -GSLFQG------------G-------------------VNWGRIVAFFVFGAALCAESV-NKEMSPLLPRIQDWMVTY-LETNLRDWIQSNGGW---------NGFLT----------- X_tropicalis_ENSXETP00000050759 -KELFAD------------G------------------VFNWGRVVALFYFACKLVVKAL-CTKVPEMIRTIINWTMEY-LREYVVQWIRDQGGW---------EGMLS----------- B_taurus_ENSBTAP00000008572 -NELFRD------------G-------------------VNWGRIVAFFSFGGALCVESV-DKEMQVLVSRIATWMATY-LNDHLEPWIQENGGW---------DTFVE----------- T_nigroviridis_ENSTNIP00000017211 -RSIFAD------------G-------------------INWGRVVALFHLAYRLILKAL-TTNHLENIRTVIGWVLQV-IREQLYSWLVQQGGW---------AGVIQ----------- M_mulatta_ENSMMUP00000005209 -ADMFSD------------G------------------NFNWGRVVALFYFASKLVLKAL-CTKVPELIRTIMGWTLDF-LRERLLGWIQDQGGW---------DGLLS----------- M_musculus_ENSMUSP00000086454 -NELFRD------------G-------------------VNWGRIVAFFSFGGALCVESV-DKEMQVLVSRIASWMATY-LNDHLEPWIQENGGWGVSGGTPLRSVFRR----------- P_troglodytes_ENSPTRP00000019323 -ADMFSD------------G------------------NFNWGRVVALFYFASKLVLKAL-CTKVPELIRTIMGWTLDF-LRERLLGWIQDQGGW---------DGLLS----------- M_mulatta_ENSMMUP00000007865 -NELFRD------------G-------------------VNWGRIVAFFSFGGALCVESV-DKEMQVLVSRIAAWMATY-LNDHLEPWIQENGGW---------DTFVE----------- C_familiaris_ENSCAFP00000010478 -NELFRD------------G-------------------VNWGRIVAFFSFGGALCVESV-DKEMQVLVSRIAAWMATY-LNDHLEPWIQENGGW---------DTFVE----------- H_sapiens_ENSP00000365230 -NELFRD------------G-------------------VNWGRIVAFFSFGGALCVESV-DKEMQVLVSRIAAWMATY-LNDHLEPWIQENGGW---------DTFVE----------- P_pygmaeus_ENSPPYP00000012163 -NELFRD------------G-------------------VNWGRIVAFFSFGGALCVESV-DKEMQVLVSRIAAWMATY-LNDHLEPWIQENGGW---------DTFVE----------- P_troglodytes_ENSPTRP00000022903 -NELFRD------------G-------------------VNWGRIVAFFSFGGALCVESV-DKEMQVLVSRIAAWMATY-LNDHLEPWIQENGGW---------DTFVE----------- G_gallus_ENSGALP00000010059 -NELFHD------------G-------------------VNWGRIVAFFSFGGALCVESV-DKEMRVLVGRIVSWMTTY-LTDHLDPWIQENGGW---------ERFVD----------- X_tropicalis_ENSXETP00000053903 -GELFRD------------G-------------------TNWGRIVAFFSFGRALCVESA-NKEMTELLPRIVQWMVQY-LEHTLQPWMLENGGW---------EAFVG----------- M_domestica_ENSMODP00000024313 -NELFRD------------G-------------------VNWGRIVAFFSFGGALCVESV-DKEMEVLVGRITSWMATY-LDDHLDPWIQENGGW---------DTFVE----------- A_carolinensis_ENSACAP00000017311 -EELFQD------------G-------------------VNWGRIVAFFEFGGMLCVESV-SREMSPLVDNIATWMTEY-LNQYLRNWIQENGGW------------------------- D_rerio_ENSDARP00000023687 -REIFSD------------G------------------KFNWGRVVALFYFACRLVIKAI-STRVPDIIRTIISWTMSY-IQEHVINWIREQGGW---------DGIRS----------- T_nigroviridis_ENSTNIP00000002788 -DELFRD------------G-------------------VNWGRIIAFFEFGAAVCAECAAKEEMSPQVDNIAEWMTEY-LSGSLNSWIQDNGGW---------RRFKK----------- D_rerio_ENSDARP00000096467 -EELFRD------------G-------------------VNWGRIIAFFEFGGTMCVESV-NREMASQVDNIAHWMTDY-LNGPLENWIEENGGW---------DAFVE----------- O_cuniculus_ENSOCUP00000002775 -NELFRD------------G-------------------VNWGRIVAFFSFGGALCVESV-DKEMEVLVSRIAAWMATY-LNDHLEPWIQENGGW------------------------- B_taurus_ENSBTAP00000017739 -AEMFSD------------G------------------NFNWGRVVALFYFASKLVLKAL-CTKVPELIRTIMGWTLDF-LRERLLGWIQDQGGW---------DGLLS----------- T_nigroviridis_ENSTNIP00000013781 -DQIFEG------------N-------------------VHWGVVIGLFVVGGAMCVQCV-RNNHEELVCHIADWMTAY-LDEHLEPWIQRQGGW---------EDFTR----------- O_anatinus_ENSOANP00000014671 -DELFQG------