>R_norvegicus_ENSRNOP00000011839 ------------------------------------------------------------ ---------------MERRGGFPPRAAGETVPSP----FLTPGPSLPYSLLPPLRLALPL PEELPSL-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-AST-LLRDEE-------------LEE-IK--------------------------KET ------------------G-FSHSQITRLYSRFTSLDKGEN------G-----TLSREDF QRI-----PELAINPLGDRIINAFFSEG--E---------DQVNFRGFMRTLAHFRPIED NEKS-KDVNGPEPLNSRSNKLHFAFRLY-DLDKDDKISRDELLQVLRM---MVGV----N --ISDEQLGSIADR----TIQEADQDGD--SA---------ISFTEFVKV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKV-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLH------------- >H_sapiens_ENSP00000335632 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-AST-LLRDEE-------------LEE-IK--------------------------KET ------------------G-FSHSQITRLYSRFTSLDKGEN------G-----TLSREDF QRI-----PELAINPLGDRIINAFFPEG--E---------DQVNFRGFMRTLAHFRPIED NEKS-KDVNGPEPLNSRSNKLHFAFRLY-DLDKDEKISRDELLQVLRM---MVGV----N --ISDEQLGSIADR----TIQEADQDGD--SA---------ISFTEFVKV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKV-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLH------------- >M_mulatta_ENSMMUP00000022485 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-AST-LLRDEE-------------LEE-IK--------------------------KET ------------------G-FSHSQITRLYSRFTSLDKGEN------G-----TLSREDF QRI-----PELAINPLGDRIINAFFPEG--E---------DQVNFRGFMRTLAHFRPIED NEKS-KDVNGPEPLNSRSNKLHFAFRLY-DLDKDEKISRDELLQVLRM---MVGV----N --ISDEQLGSIADR----TIQEADQDGD--SA---------ISFTEFVKV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKV-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLH------------- >P_troglodytes_ENSPTRP00000011844 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-AST-LLRDEE-------------LEE-IK--------------------------KET ------------------G-FSHSQITRLYSRFTSLDKGEN------G-----TLSREDF QRI-----PELAINPLGDRIINAFFPEG--E---------DQVNFRGFMRTLAHFRPIED NEKS-KDVNGPEPLNSRSNKLHFAFRLY-DLDKDEKISRDELLQVLRM---MVGV----N --ISDEQLGSIADR----TIQEADQDGD--SA---------ISFTEFVKV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKV-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLH------------- >B_taurus_ENSBTAP00000038767 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-AST-LLRDEE-------------LEE-IK--------------------------KET ------------------G-FSHSQITRLYSRFTSLDKGEN------G-----TLSREDF QRI-----PELAINPLGDRIINAFFPEG--E---------DQVNFRGFMRTLAHFRPIED NEKS-KDVNGPEPLNSRSNKLHFAFRLY-DLDKDDKISRDELLQVLRM---MVGV----N --ISDEQLGSIADR----TIQEADQDGD--SA---------ISFTEFVKV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKV-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLH------------- >C_familiaris_ENSCAFP00000014010 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-AST-LLRDEE-------------LEE-IK--------------------------KET ------------------G-FSHSQITRLYSRFTSLDKGEN------G-----TLSREDF QRI-----PELAINPLGDRIINAFFPEG--E---------DQVNFRGFMRTLAHFRPIED NEKS-KDVNGPEPLNSRSNKLHFAFRLY-DLDKDDKISRDELLQVLRM---MVGV----N --ISDEQLGSIADR----TIQEADQDGD--SA---------ISFTEFVKV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKV-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLH------------- >E_caballus_ENSECAP00000017232 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-AST-LLRDEE-------------LEE-IK--------------------------KET ------------------G-FSHSQITRLYSRFTSLDKGEN------G-----TLSREDF QRI-----PELAINPLGDRIINAFFPEG--E---------DQVNFRGFMRTLAHFRPIED NEKS-KDVNGPEPLNSRSNKLHFAFRLY-DLDKDDKISRDELLQVLRM---MVGV----N --ISDEQLGSIADR----TIQEADQDGD--SA---------ISFTEFVKV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKV-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLH------------- >M_domestica_ENSMODP00000000182 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-AST-LLRDEE-------------LEE-IK--------------------------KET ------------------G-FSHSQITRLYSRFTSLDKGEN------G-----TLSREDF QRI-----PELAINPLGDRIINAFFPEG--E---------DQVNFRGFMRTLAHFRPIED NEKS-KDVNGPEPLNSRSNKLHFAFRLY-DLDKDDKISRDELLQVLRM---MVGV----N --ISDEQLGSIADR----TIQEADQDGD--SA---------ISFTEFVKV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKV-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLH------------- >O_anatinus_ENSOANP00000007131 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-AST-LLRDEE-------------LEE-IK--------------------------KET ------------------G-FSHSQITRLYSRFTSLDKGEN------G-----TLSREDF QRI-----PELAINPLGDRIINAFFPEG--E---------DQVNFRGFMRTLAHFRPIED NEKS-KDVNGPEPLNSRSNKLHFAFRLY-DLDKDDKISRDELLQVLRM---MVGV----N --ISDEQLGSIADR----TIQEADQDGD--SA---------ISFTEFVKV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKV-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLH------------- >M_musculus_ENSMUSP00000014221 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-AST-LLRDEE-------------LEE-IK--------------------------KET ------------------G-FSHSQITRLYSRFTSLDKGEN------G-----TLSREDF QRI-----PELAINPLGDRIINAFFSEG--E---------DQVNFRGFMRTLAHFRPIED NEKS-KDVNGPEPLNSRSNKLHFAFRLY-DLDKDDKISRDELLQVLRM---MVGV----N --ISDEQLGSIADR----TIQEADQDGD--SA---------ISFTEFVKV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKV-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLH------------- >R_norvegicus_ENSRNOP00000023713 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-AST-LLRDEE-------------LEE-IK--------------------------KET ------------------G-FSHSQITRLYSRFTSLDKGEN------G-----TLSREDF QRI-----PELAINPLGDRIINAFFSEG--E---------DQVNFRGFMRTLAHFRPIED NEKS-KDVNGLEPLNSRSNKLHFAFRLY-DLDKDDKISRDELLQVLRM---MVGV----N --ISDEQLGSIADR----TIQEADQDGD--SA---------ISFTEFVKV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKV-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLH------------- >G_gallus_ENSGALP00000032005 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-AST-LLRDEE-------------IEE-IK--------------------------KET ------------------G-FSHSQITRLYSRFTSLDKGEN------G-----TLSREDF QRI-----PELAINPLGDRIINAFFSEG--E---------DQVNFRGFMRTLAHFRPIED NEKS-KDQNGPEPLNSRSNKLHFAFRLY-DLDKDDKISRDELLQVLRM---MVGV----N --ISDEQLGSIADR----TIQEADQDGD--CA---------ISFAEFVKV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKV-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLH------------- >A_carolinensis_ENSACAP00000003613 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-AST-LLRDEE-------------IEE-IK--------------------------KET ------------------G-FSHSQITRLYSRFTSLDKGEN------G-----TLSREDF QRI-----PELAINPLGDRIINAFFPEG--E---------DQVNFRGFMRTLAHFRPIED NEKN-KDQNGLEPLNSRSNKLHFAFRLY-DLDKDDKISRDELLQVLRM---MVGV----N --ISDEQLGSIADR----TIQEADQDGD--SA---------ISFAEFVKV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKV-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLH------------- >T_guttata_ENSTGUP00000011150 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-ASI-CCR-RE-------------IVE-IK--------------------------KRR ------------------A-VSHSQITRLYSRFTSLDKGEN------G-----TLSREDF QRI-----PELAINPLGDRIINAFFPEG--E---------DQVNFRGFMRTLAHFRPIED NEKS-KDQNGPEPLNSRSNKLHFAFRLY-DLDKDDKISRDELLQVLRM---MVGV----N --ISDEQLGSIADR----TIQEADQDGD--SA---------ISFAEFVKV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKV-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLH------------- >P_pygmaeus_ENSPPYP00000007213 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-AST-LLRDEE-------------LEE-IK--------------------------KET ------------------G-CEFGTNFVLFSFPHNLDKGYN------G-----TLSREDF QRI-----PELAINPLGDRIINAFFPEG--E---------DQVNFRGFMRTLAHFRPIED NEKS-KDVNGPEPLNSRSNKLHFAFRLY-DLDKDEKISRDELLQVLRM---MVGV----N --ISDEQLGSIADR----TIQEADQDGD--SA---------ISFTEFVKV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKV-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLH------------- >R_norvegicus_ENSRNOP00000006380 ------------------------------------------------------------ ------------------------------------------------------------ ------I-H--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------Y K-STF-GGQMPD-------------WDR-FL--------------------------NNT ------------------LFFSHSQITRLYSRFTSLDKGEN------G-----TLSREDF QRI-----PELAINPLGDRIINAFFSEG--E---------DQVNFRGFMRTLAHFRPIED NEKS-KDVNGPEPLNSRSNKLHFAFRLY-DLDKDDKISRDELLQVLRM---MVGV----N --ISDEQLGSIADR----TIQEADQDGD--SA---------ISFTEFVKV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKV-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLH------------- >O_latipes_ENSORLP00000011997 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-AST-LLREEE-------------IEE-IK--------------------------KET ------------------G-FSHSQITRLYSRFTSLDKGEN------G-----TLSREDF QRI-----PELAINPLGDRIINAFFPDG--E---------DQVNFRGFMRTLAHFRPVED NEKN-KNLSNTEPLNSRTNKLHFAFQLY-DLDRDDKISRDELLQVLRM---MVGV----N --ISDEQLGSIADR----TIQEADTNGD--GC---------ISFTEFIKV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKV-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLH------------- >T_rubripes_ENSTRUP00000030807 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-AST-LLREEE-------------IEE-IK--------------------------KET ------------------G-FSHSQITRLYSRFTSLDKGEN------G-----TLSREDF QRI-----PELAINPLGDRIINAFFPEG--E---------DQVNFRGFMRTLAHFRPIED NEKN-KNAATSEPLNSRTNKLLFAFRLY-DLDRDDKISRDELLQVLRM---MVGV----N --ISDDQLGSIADR----TIQEADTNGD--NS---------ISFTEFVKV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKV-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLH------------- >X_tropicalis_ENSXETP00000057366 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-AST-LLRDEE-------------IEE-IK--------------------------KET ------------------G-FSHSQITRLYSRFTSLDKGEN------G-----TLSREDF QRI-----PELAINPLGDRIINAFFTEG--E---------DQVNFRGFMRTLAHFRPIED N--S-KDANSQEPLNSRSNKLLFAFRLY-DLDKDDKISREELLQVLRM---MVGV----N --ISDDQLGSIADR----TIQEADQDGD--SA---------ISFTEFVKV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKV-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLH------------- >O_cuniculus_ENSOCUP00000011896 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-AST-LLRDEE-------------LEE-IK--------------------------KET ------------------G-FSHSPFTRLYSRFTSLDKGEN------G-----TLSREDF QRI-----PELAINPLGDRIINAFFPEG--E---------DQVNFRGFMRTLAHFRPIED NEKS-KDVNGPEPLNSRSNKLHXXXXXX-XXXXXXXXXXXXXXXVLRM---MVGV----N --ISDEQLGSIADR----TIQEADQDGD--SA---------ISFTEFVKV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKV-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLH------------- >D_rerio_ENSDARP00000069277 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-ASS-LLREED-------------IEE-IK--------------------------KET ------------------G-FSHSQITRLYSRFHSLDKGEN------G-----GLSREDF QRI-----PELAINPLGDRIINAFFPEG--E---------DQVNFRGFMRTLAHFRPVED NEKN-KDLTG-EPLNSRTNKLLFAFRLY-DLDRDDKISRDELLQVLRM---MVGV----N --ISDEQLGSIADR----TIQEADTNGD--MC---------ISFNEFTKV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKV-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLH------------- >T_nigroviridis_ENSTNIP00000022556 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-AST-LLREEE-------------IEE-IK--------------------------KET ------------------G-FSHSQITRLYSRFTSLDKGEN------G-----TLSREDF QRI-----PELAINPLGDRIINAFFPEG--E---------DQVNFRGFMRTLAHFRPIED NEKN-KN-PTVEPLNSRTNKLLFAFRLY-DLDRDDKISRDELLQVLRM---MVGV----N --ISDDQLGSIADR----TIQEADTNGD--NS---------ISFNEFIKV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKV-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLH------------- >G_aculeatus_ENSGACP00000016117 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S K-AST-LLREEE-------------IEE-IK--------------------------KET ------------------G-FSHSQITRLYSRFTSLDKGEN------G-----TLSREDF QRI-----PELAINPLGDRIINAFFPEG--E---------DQVNFRGFMRILAHFRPIED NEK--KSVAVSEPLNSRTNKLLFAFRLY-DLDRDDKISREELLQVLRM---MVGV----N --ISDDQLGSIADR----TIQEADTNGD--NS---------ISFNEFIKV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKV-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLH------------- >M_mulatta_ENSMMUP00000015123 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-SSH-AAVIPD-------------ADS-IR--------------------------RET ------------------G-FSQASLLRLHHRFRALDRNKK------G-----YLSRMDL QQI-----GALAVNPLGDRIIESFFPDG--S---------QQVDFPGFVRVLAHFRPVED EDTETQDPKKPEPLNSRRNKLHYAFQLY-DLDRDGKISRHEMLQVLRL---MVGV----Q --VTEEQLENIADR----TVQEADEDGD--GA---------VSFVEFTKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKM-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------ILK------------- >H_sapiens_ENSP00000300113 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-SSH-AAVIPD-------------GDS-IR--------------------------RET ------------------G-FSQASLLRLHHRFRALDRNKK------G-----YLSRMDL QQI-----GALAVNPLGDRIIESFFPDG--S---------QRVDFPGFVRVLAHFRPVED EDTETQDPKKPEPLNSRRNKLHYAFQLY-DLDRDGKISRHEMLQVLRL---MVGV----Q --VTEEQLENIADR----TVQEADEDGD--GA---------VSFVEFTKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKM-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------ILK------------- >G_gorilla_ENSGGOP00000004209 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-SSH-AAVIPD-------------GDS-IR--------------------------RET ------------------G-FSQASLLRLHHRFRALDRNKK------G-----YLSRMDL QQI-----GALAVNPLGDRIIESFFPDG--S---------QRVDFPGFVRVLAHFRPVED EDTETQDPKKPEPLNSRRNKLHYAFQLY-DLDRDGKISRHEMLQVLRL---MVGV----Q --VTEEQLENIADR----TVQEADEDGD--GA---------VSFVEFTKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKM-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------ILK------------- >P_pygmaeus_ENSPPYP00000008138 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-SSH-AAVIPD-------------GDS-IR--------------------------RET ------------------G-FSQASLLRLHHRFRALDRNKK------G-----YLSRMDL QQI-----GALAVNPLGDRIIESFFPDG--S---------QRVDFPGFVRVLAHFRPVED EDTETQDPKKPEPLNSRRNKLHYAFQLY-DLDRDGKISRHEMLQVLRL---MVGV----Q --VTEEQLENIADR----TVQEADEDGD--GA---------VSFVEFTKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKM-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------ILK------------- >P_troglodytes_ENSPTRP00000013478 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-SSH-AAVIPD-------------GDS-IR--------------------------RET ------------------G-FSQASLLRLHHRFRALDRNKK------G-----YLSRMDL QQI-----GALAVNPLGDRIIESFFPDG--S---------QRVDFPGFVRVLAHFRPVED EDTETQDPKKPEPLNSRRNKLHYAFQLY-DLDRDGKISRHEMLQVLRL---MVGV----Q --VTEEQLENIADR----TVQEADEDGD--GA---------VSFVEFTKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKM-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------ILK------------- >R_norvegicus_ENSRNOP00000025832 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-SSH-VALIPD-------------VDQ-IR--------------------------RET ------------------G-FSQASLLRLYHRFQALDREEK------G-----FLSRLDL QQI-----GALAVNPLGDRIIDSFFPNG--S---------QRVYFAGFARVLAYFRPIDE DDATLRDPKQPEPLNSRMNKLRFAFQLY-DLDRDGKISRNEMLQVLRL---MVGV----Q --VTDEQLESITDR----TVQEADEDGD--GA---------VSFLEFAKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKM-NIE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------ILK------------- >M_musculus_ENSMUSP00000033152 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-SSH-IALIPD-------------VEH-IR--------------------------RET ------------------G-FSQASLLRLYHRFQALDRDEK------G-----FLSRLDL QQI-----GALAVNPLGDRIIDSFFPNG--S---------QRLYFAGFARVLAYFRPIDE EDATLRDPKQPEPLNSRMNKLRFAFQLY-DLDRDGKISRNEMLQVLRL---MVGV----Q --VTDEQLESITDR----TVQEADEDGD--GA---------VSFLEFTKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKM-NIE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------ILK------------- >B_taurus_ENSBTAP00000016647 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S R-SSH-AARIPD-------------VDS-LR--------------------------QET ------------------G-FSQASLRRLYDRFNALDRTGK------G-----YLSRMDL QQI-----GALAVNPLGDRIIDSFFPDG--S---------LRLDFPGFVRVLAHFRPVDE EDDGNRDPKEPEPLNSRMNKLRFAFQLY-DLDRDGKISRHEMLQALRL---MVGV----Q --VTEEQLESIADR----TVQEADEDGD--GA---------VSFLEFAKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKM-NIE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------ILK------------- >G_gorilla_ENSGGOP00000007156 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------E---------DQVNFRGFMRTLAHFRPIED NEKS-KDVNGPEPLNSRSNKLHFAFRLY-DLDKDEKISRDELLQVLRM---MVGV----N --ISDEQLGSIADR----TIQEADQDGD--SA---------ISFTEFVKV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKV-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLH------------- >A_gambiae_AGAP001760-PA ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-SSL-LLREEE-------------IAQ-IH--------------------------EET ------------------G-FTPNQIERLYSRFTSLDRNDC------G-----TLSREDF LRI-----PELAINPLCERIVHSFFADS--N--------DDRVNFRQFTRVLAHFRPIKP --------NKENRLNSREEKLRFAFKMY-DLDDDETISRDELLNILQM---MVGA----N --ISQDQLNSIAER----TIVEADTVGV--GK---------ISFDDFCRA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LERT-EVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLN------------- >D_melanogaster_FBpp0078381 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-SSL-FLRNEE-------------IAQ-IQ--------------------------EET ------------------G-FTPNQIERLYSRFTSLDRNDC------G-----TLSREDL MRI-----PELAINPLCERIVHSFFAES--N--------DDRVNFRQFMNVLAHFRPLRD --------NKQSKLNSREEKLKFAFKMY-DLDDDGVISRDELLSILHM---MVGA----N --ISQDQLVSIAER----TILEADLCCQ--GK---------ISFEDFCKA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LDRT-DVD---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLN------------- >D_rerio_ENSDARP00000008534 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S S-SSTLLKKIPN-------------VDE-LM--------------------------QET ------------------G-FSPAHIIRLYERFEALDKERR------G-----HLCPQDF GAI-----KELAMNPIGDRIIDAFFSPG--K---------DTVDFHTFVKILAHFRPVDK DRP--KEPNSPEPINSRSNKLKFAFQLY-DQDKDGKISRDELLKVLRD---MLGL----Q --VTEEQLESIADR----TIQEADLDRD--DA---------ISFEEFRKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKV-NID---HKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLR------------- >A_aegypti_AAEL007494-PA ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-SSL-LLREEE-------------IAQ-IH--------------------------EET ------------------G-FTPNQIERLYSRFTSLDRSDC------G-----TLTREDF LRI-----PELAINPLCERIVHSFFADS--S--------DDRVNFRQFTQVLAHFRPIKP --------NKENKLNSREEKLRFAFKMY-DLDDDDNISRDELLSILQM---MVGA----N --ISQDQLNSIAER----TIVEADSMGQ--GK---------ITFEDFCRA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LERT-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLN------------- >C_familiaris_ENSCAFP00000026013 ------------------------------------------------------------ ------------------------------------------------------------ --------G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------E R-PRP-CHPPPP-----------------GP----------------------------- ------------------A-VSQASLLRLYHRFRALDRNKK------G-----YLSRMDL QQI-----GALAVNPLGDRIIDSFFPDG--N---------LRVDFPGFVRVLAHFRPVDD DDSSMRDPKEPEPLNSRMNKLRFAFQLY-DLDRDGKISRHEMLQVLRL---MVGV----Q --VTEEQLESIADR----TVQEADEDGD--GA---------VSFLEFTKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKM-DIE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------ILK------------- >A_carolinensis_ENSACAP00000000758 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------A Q-NSQ-PFTVPE-------------QEE-IM--------------------------AET ------------------G-FSQANVLRLYQRFQALDKDEK------G-----YLSKYDL ENI-----GTLAVNPIGDRIINAFFQDG--A---------VTTDFRTFARVLAHFRPVEG -------PGESGSINSRLNKLKFAFQLY-DQDKDGKISRAEMLQVLRM---MIGI----Q --VTDEQLECITDR----TIQEADKDGD--DA---------ISFEEFAKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VEKL-NIE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LR-------------------ILK------------- >E_caballus_ENSECAP00000015073 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------A-FSQAIFLRLYHRFRALDTNKK------D-----YLSRMDL QQI-----GALAVNPLGDRIIDSFFPDG--S---------LQVDFPDFVRVLAHFRPADD EDAGLRDPREPEPLNSRMNKLRFAFQLY-DLDRDGKISRHEMLQVLRL---MVGV----Q --VTEEQLESIAER----TVQEADEDGD--GA---------VSFLEFAKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKM-DIE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------ILK------------- >C_elegans_ZK856.8.1 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N S-SSL-MLRDEE-------------IEE-IM--------------------------SET ------------------E-FNRNQIVRLYSRFLSLDKKGQ------G-----FLSRDDF LNV-----PELAVNPLGDRIVDAFFTLA--S--SNGDNEEQQLNFRQFVRILAHFQPISR --------VKKNALNSRKDKLLFAFKMY-DLNKNDYITREEFKVILNS---MVGA----N --ITSDQLDKIADR----TIEEADADRD--GK---------ISFDEFCRA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------MEKT-DIE---EKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLN------------- >O_latipes_ENSORLP00000000503 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S G-SSS-LKHIPD-------------GQQ-LM--------------------------EET ------------------G-FSAAHLLRLHERFDFLDKDGR------G-----HLRPEDF EEI-----RELTENPIGGRIIAAFFPPE--K---------ERLDFPSFVRILAHFRPIGK NRS--RDRAQPEQANSRTGKLKFAFELY-DQDRDGKISREELLQVLRA---MLGL----Q --VTEEQLRSIAER----AVQEADIDGD--GA---------ISFDEFKKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEKV-DME---HKMN------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLK------------- >A_aegypti_AAEL015549-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------TPNQIERLYSRFTSLDRSDC------G-----TLTREDF LRI-----PELAINPLCERIVHSFFADS--S--------DDRVNFRQFTQVLAHFRPIKP --------NKENKLNSREEKLRFAFKMY-DLDDDDNISRDELLSILQM---MVGA----N --ISQDQLNSIAER----TIVEADSMGQ--GK---------ITFEDFCRA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LERT-DVE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLN------------- >C_elegans_F59D6.7 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N S-NSS-ILSDAE-------------MRE-IM--------------------------DET QCKVCVIIAKQFTPKNTIS-VNKHQILRLYTRFASLDKNGQ------G-----YLSRDDF LNV-----PELAVNPLGDRIIDAFFTLG--D--SDGDSKSGQLTFRQFVRILAHFQPISK --------VKDNALNSRKDKLRFAFKMY-DLNKNNYITREEFKVILNS---MVGA----N --ITSDQLDKIADK----TLEEADQDRD--GK---------ISFEDFCRA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------MEKT-DIE---EKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MR-------------------FLN------------- >C_elegans_Y71H2AL.1 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------Q N-SS--QIPEHE-------------LEH-LS--------------------------IES ------------------G-LSRGGILKLYGRFISLATHRD------KTTNEYFLTKGDF QSI-----AELKQNPLGDRIIDAFFADA--E-----VLERRKVYFKDFVKVLSHFRPINK --------NKPHPWNSREAKLRFAFTMY-DLNKSGTITKDEFQDILAM---MIGV----G --VPKDQVNSIADR----TMREADRDGD--GF---------ITFQEFCNA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------MEKT-DIE---QKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------FR-------------------FLT------------- >O_anatinus_ENSOANP00000011626 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SQANLSRLHHRFRALDKDSK------G-----YLSRQDL QSI-----GKLAVNPLGDRIVSSFFPAG--E---------ERVDFRGFVRVLAHFRPLED DGGP-QTLENPEPLNSRDNKLRFAFQLY-DQDRDGKISREEMLQVGER---DHKX----H --LCDKEALYWHHP----VPSLQEMTGN--GS---------SDFREQPQS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LETL-NVE---HRMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LR-------------------ILK------------- >O_cuniculus_ENSOCUP00000000687 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S S-GSH-ATVIPD-------------GDS-IR--------------------------RET ------------------G-FSQASLLRLYHRFRALDRNKK------G-----YLSRMDL QQI-----GALAVNPLGDRIIDSFFPDG--S---------QRVDFSGFVRVLAHFRPVDE EEAGIRDPKQPEPLNSRMNKLRFAFQLY-DLDRDGKISRHEMLQ---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >T_rubripes_ENSTRUP00000031162 ------------------------------------------------------------ ------------------------------------------------------------ ------Q-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-ASY------P-------------LEM-C-----------------------------S ------------------H-FDADEIKRLGKRFKKLDLDNS------G-----SLSVEEF MSL-----PELQQNPLVQRVIDIFDTDG--N---------GEVDFKEFIEGVSQFSVKGD ----------------KEQKLRFAFRIY-DMDKDGYISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TIINADKDGD--GR---------ISFEEFCAVSLSPGWVFWG LMPQVG--EETWPSPIVSFKSLCKYIAK----NN--PLVYTWMVISDCAL--VCKSL--H VQIFCQLS---IIKSKGQKSIHLLFSSNGSSASELQVRKIYSLTACSPVDVQHL-YSCSR SRTKGIYKGWRLVPQIHSKGCVLNVTSNISGIQSINTPVHWLKVNTKLPKLKLPQFPSFY MFLKRKRRGLSLLVVYQAATMS----TPLAKPQIITHIQKSLNYTVFDSKWIPCSARFIC LGNFPRGTGVMQIYEVQRGEVQLIKEVEKPKPLKCGTFGATSLQQRHIATGDFDGNLSIW NLEMPGTPVYTV-KAH---KEIVNCIDGAGGLGMADGAPEIVTGSRDGTVKVWDPRQKDT PVANMEPVEGETKRDCWTVAFGHAFNDEERCVCAGYDNGDIKLFDLRNMRLRWETNIKNG VCCVEFDRKNINMNKLVATSLEGKFHTFDLRTQHPTKGFASVSEKAHKSTIWQVRHLPQN RDIFMTTGGAGNLHLWKYEYPAQRRKKDSDGVDVGVAGSLNLLQNVTLSTQPLNSLDWSP DKQGLCVCSGFDQCVR-------------------VLIVTKLNQV------ >A_carolinensis_ENSACAP00000001097 ------------------------------------------------------------ ------------------------------------------------------------ --------G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-ASY------P-------------LEM-C-----------------------------S ------------------H-FDADEIKRLGKRFKKLDLDNS------G-----SLSVEEF MSL-----PELQQNPLVQRVIDIFDTDG--N---------GEVDFKEFIEGVSQFSVKGD ----------------KEQKLRFAFRIY-DMDKDGYISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TIINADKDGD--GR---------ISFEEFCA----------- -----------VPSPPPDRCSAHQ-GAV----AP--TLEIT--TKSKTKTR-LACRIGLA CPYCTSVK------AHERSNAQL--AKVSLSSAQLRYSNIWKLTVSGKLAGIS--ESCRP KHVGTHRLRTRPHPEGLSAQRREVGPLPGLG--SLARVHGALPRRQEKATRVLPCPRGVT AP-----------LACLQLAMSSPSGTSLEKPQIIAHAQQGLNYTVFECKWVPCSARLVC LGSFPRGTGVIQLYELAGGRLSLRREIEKPRPIKCGTFGAASLQQRYLATGDFGGNLNIW NLEAPETPVYSA-KGH---EEIINCIDGVGGLGVGEGAPEIVTGSRDGTVKVWDPRQKDI PVANMEPAQGESKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLKNMTLRWETNIKNG VCSVEFDRKDINMNKLVATSLEGKFHVFDMRTQHPTKGFASISEKAHKSTMWQVRHLPQN RDIFLTSGGAGSLHLWKYDYPAERSKKDSEGTAMGVAGSVSLLQNVTLSTQPISSLDWSP DKRGLCVCSAFDQTVR-------------------VLIVTKLNRV------ >P_troglodytes_ENSPTRP00000020605 -----------------------------------------------------------M YRQISSRKVGTEQMGLRVLHRGDSSPDGPCNSVV----DPSRYTDAQIPLTASRRTWIFP VFWCGIR-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-ASY------P-------------LEM-C-----------------------------S ------------------H-FDADEIKRLGKRFKKLDLDNS------G-----SLSVEEF MSL-----PELQQNPLVQRVIDIFDTDG--N---------GEVDFKEFIEGVSQFSVKGD ----------------KEQKLRFAFRIY-DMDKDGYISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TIINADKDGD--GR---------ISFEEFCARGGKTG-LFAG LASSVSMRPASPPSPAADSCSACRFFAR----RP--PLRVTW-VKPSSAPA-LCASI--S DSIPGNLK---ALPAETRAQLHH--AEASLSQPPLQLRPFPKTSQAGDLQDLGP-YVCVR KAVGKGDKQIRAVVKEHSVRSQERIWHYPGI--TTANMPGHLGQNTESGRDKLP-MFGVW LP-FLGALGVAVAVAEIGCTMS-----AFEKPQIIAHIQKGFNYTVFDCKWVPCSAKFVT MGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKCGTFGATSLQQRYLATGDFGGNLHIW NLEAPEMPVYSV-KGH---KEIINAIDGVGGLGIGEGAPEIVTGSRDGTVKVWDPRQKDD PVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRNMALRWETNIKNG VCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTKGFASVSEKAHKSTVWQVRHLPQN RELFLTAGGAGGLHLWKYEYPIQRSKKDSEGIEMGVAGSVSLLQNVTLSTQPISSLDWSP DKRGLCVCSSFDQTVR-------------------VLIVTKLNKI------ >P_pygmaeus_ENSPPYP00000013774 -----------------------------------------------------------M YRQISSRKVGTEQMGLRVLHRGDSSPDRPCNSVV----DPSRYMDAQIPLTACRRTWIFP VFWCGIR-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-ASY------P-------------LEM-C-----------------------------S ------------------H-FDADEIKRLGKRFKKLDLDNS------G-----SLSVEEF MSL-----PELQQNPLVQRVIDIFDTDG--N---------GEVDFKEFIEGVSQFSVKGD ----------------KEQKLRFAFRIY-DMDKDGYISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TIINADKDGD--GR---------ISFEEFCARGGKTG-LFAG LASSVSMRSASPLSPAADSCSACRFFAR----RP--PLRVTW-VKPSSAPA-LCASI--S DSIPGNLK---ALPPETRVQLHR--AGASLSQPPLQLRPFPKTSQAGDLHDLGP-YVCVR KAGGKGDKQISAVVKEHSVRSQERIWHYPEI--TTANMLGHLGQNTESGRDKLP-MFGIW LL-FLGALGVAVAVAEIRCTMS-----AFEKPQIIAHIQKGFNYTVFDCKWVPCSAKFVT MGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKCGTFGATSLQQRYLATGDFGGNLHIW NLEAPEMPVYSV-KGH---KEIINAIDGVGGLGIGEGAPEIVTGSRDGTVKVWDPRQKDD PVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRNMALRWETNIKNG VCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTKGFASVSEKAHKSTVWQVRHLPQN RELFLTAGGAGGLHLWKYEYPIQRSKKDSEGIEMGVAGSVSLLQNVTLSTQPISSLDWSP DKRGLCVCSSFDQTVR-------------------VLIVTKLNKI------ >M_mulatta_ENSMMUP00000022984 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------M-C-----------------------------S ------------------H-FDADEIKRLGKRFKKLDLDNS------G-----SLSVEEF MSL-----PELQQNPLVQRVIDIFDTDG--N---------GEVDFKEFIEGVSQFSVKGD ----------------KEQKLRFAFRIY-DMDKDGYISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TIINADKDGD--GR---------ISFEEFCARGGKTG-LFAG LASSVSIRPASPPSPAADSCSACRFFAR----RP--PLRVTW-VKPSSAPA-LCASI--S DSIPRNLK---ALPAETRALLHR--AGPSLRQLTPQLRPFPKTSQAGDLQDLGPGENGIS AAVGKGNKEICAVVKEHSVRSPERIWHYLEI--TTANFLGYLGQNTESGRDKLP-MFGVW FPVFWGASGVAVVRTEIGCTMS-----AFEKPQIIAHIQKGFNYTVFDCKWVPCSAKFVT MGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKCGTFGATSLQQRYLATGDFGGNLHIW NLEAPEMPVYSV-KGH---KEIINAIDGVGGLGIGEGAPEIVTGSRDGTVKVWDPRQKDD PVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRNMALRWETNIKNG VCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTKGFASVSEKAHKSTVWQVRHLPQN RELFLTAGGAGGLHLWKYEYPIQRSKKDSEGIEMGVAGSVSLLQNVTLSTQPISSLDWSP DKRGLCVCSSFDQTVR-------------------VLIVTKLHKI------ >O_cuniculus_ENSOCUP00000005274 ------------------------------------------------------------ --------------GLGSQHR-DNSPGAPCGSEG----GPRPHAHARILCSLSSR----- -FGSGVR-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-ASY------P-------------LEM-C-----------------------------S ------------------H-FDADEIKRLGKRFKKLDLDNS------G-----SLSVEEF MSL-----PELQQNPLVQRVIDIFDTDG--N---------GEVDFKEFIEGVSQFSVKGD ----------------KEQKLRFAFRIY-DMDKDGYISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TIINADKDGD--GR---------ISFEEFCARGGKTG-LLAG RASSVSMRPASPPSPDADSCSACRFFAR----RP--PLRVT--VKPSSDPA-PCVSI--S PSISGNLRAGSALPLRTRARLHR--AGAGLRQSSIGLRPFPK-SHAGDLNHP---YVCVN TAF-KGYNQILAFVKKRLMQSQHRIRH-SEI--TKSKLLER-GPSTASGRDKLF-VFGVW LV-------FAVAGGEIGWTMS-----AFEKPQVIAHIQKSLNYTVFDCKWVPCSAKFVT VGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKCGTFGAASLQQRHLATGDFGGNLHIW NLEAPEVPVYSV-KGH---KEIINTIDGVGGLGVGEGAPEIVTGSRDGTVKVWDPRQKDD PVANMEPVQGEHKRDCWTVAFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX VCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTKGFASVSEKAHKSTVWQVRHLPQN RELFLTAGGAGSLHLWKYEYPVRRSKKDSEGVDMGVAGSVSLLQNVTLSTQPISSLDWSP DKRGLCVCSSFDQVVR-------------------VLIVTKLHTL------ >H_sapiens_ENSP00000387216 ------------------------------------------------------------ -----------------------------------------------MQPQCPLRRESCG MELCGKK-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-ASY------P-------------LEM-C-----------------------------S ------------------H-FDADEIKRLGKRFKKLDLDNS------G-----SLSVEEF MSL-----PELQQNPLVQRVIDIFDTDG--N---------GEVDFKEFIEGVSQFSVKGD ----------------KEQKLRFAFRIY-DMDKDGYISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TIINADKDGD--GR---------ISFEEFCAV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VGGL-DIH---KKMV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VD-------------------V--------------- >O_latipes_ENSORLP00000002909 ------------------------------------------------------------ ------------------------------------------------------------ --------G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-ASY------P-------------LEM-C-----------------------------S ------------------H-FDADEIKRLGKRFKKLDLDNS------G-----SLSVEEF MSL-----PELQQNPLVQRVIDIFDTDG--N---------GEVDFKEFIEGVSQFSVKGD ----------------KEQKLRFAFRIY-DMDKDGYISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TIINADKDGD--GR---------ISFEEFCA--AETG-LLVC GTLDISVKYKAAPSEFSSCCSTNQSFIK----KTNNPLVYTWMVKPDLKLQ-VLHDG--S EDLQPVLL-QRRVPMSRDGNLPH--LIRTLEHTKKNSRRFIKKSEAEQMHICGQ-LIVVA VATGKGVRNV-NVLNRQAQSGQEEVKHEPGG--PTADQRTTEAQHSIESRMIFL-SSGIT DQ------FFNALGVDFKFSASVNMSSSLSKPQIIAHAHTGLNFTVFDCKWIPCSAKFVC LGNFPRGTGVIQIHELQHGEVQLVKELEKPKPIKCGTFGASSLQTRHIATGDFDGNLNIW NLEAADVPVYSV-KAH---KEIVNSIDGVGGLGIGEGAPEIVTGSRDGTVKVWDPRQRDW PVANMEPLEGETRRDCWTVAFGHAFNQEDRCVCAGYDNGDVKLFDLRNMSLRWETNIKNG VCCVEFDRKDINMNKLVATSLEGRFHVFDMRTQHHTKGFASVSEKAHKSTIWQVRHLPQS RDVFMTTGGSGNLHLWKYEYPAQRSEKDCEGVAGGVAGSLSLLQNVTLSTQPITSLDWSP DKQGLCVCSAFDQSVR-------------------VLIVTKLNTV------ >G_aculeatus_ENSGACP00000015927 ------------------------------------------------------------ ------------------------------------------------------------ --------G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-ASF------P-------------LEM-C-----------------------------S ------------------H-FDADEIKRLGKRFKKLDLDNS------G-----SLSVEEF MSL-----PELQQNPLVQRVIEIFDTDG--N---------GEVDFKEFIEGVSQFSVKGD ----------------KEQKLRFAFRIY-DMDKDGYISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TIINADRDGD--GR---------VSFHEFCYHDAGLCDVFDG ELGLSSL-PCDPADGSGQVVSLQRFHCRHGNKRK--QLKHT--QKPDAEPRSLRLTVCDV EAFQEELVYGVSGARISATECWLVSKGKGLKSQSKTLKP----------------YICPL TSTWNPRTNALTKSDALSISTQGVLTRNLSL--DIAGNCGRLGAPGPSVSMSAPPASRFR FW------LFLDLTVVKDPASSGPSAAATGRPQIIAHIQKSLNYTVFDSKWIPCSARFVC LGNFARGTGVMQIYEVEHGEARLIKEVEKPKPIKCGTFGATSLQQRHMATGDFDGNLNIW NLEAPDVSVYSV-KAH---KEIVNCIDGVGGLGIGDGAPEIVTGSRDGTVKVWDPRQKDS PVANMEPVEGETKRDCWTVAFGHAFNDQDRCVCAGYDNGDIKLFDLRNMSLRWETNIKNG VCCVEFDRKDINMNKLVATSLEGKFHVFDLRTQHPTKGFASVSEKAHKSTIWQVKHLPQN RDIFMTTGGAGNLHLWKYEYPAQRSRTDSDQTEVGVAGSVNLLQNATLSTQPIASLDWSP DKQGLCVCSGFDQSVR-------------------VLIVTKLHAA------ >C_familiaris_ENSCAFP00000004829 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DADEIKRLGKRFKKLDLDNS------G-----SLSVEEF MSL-----PELQQNPLVQRVIDIFDTDG--N---------GEVDFKEFIEGVSQFSVKGD ----------------KEQKLRFAFRIY-DMDKDGYISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TIINADKDGD--GR---------ISFEEFCAARGGNTGLFAG RASSVSMRPASAPSPAADSCSARRFFAR----RA--PLRATG-VKPSPAAA-LWASISVS ASIPAELRRQHVLPAPTRAPLHC--AGARRGGAPPWLRRPQPGPWASQ-------RGCAR EAAGEDGSRVRAVGEETSPRLEQRVRHGRGR-----------LHRTASGRGKLSLLFGVW FP----------------GAMS-----AFEKPQIIAHIQKGLNYTVFDCKWVPCSAKFVT MGNFARGTGVVQLYEIQHGDLKLLREIEKAKPIKCGTFGATSLQQRYLATGDFAGNLHIW NLEAPEIPVYSV-KGH---KEIINTIDGVGGLGIGEGAPEIVTGSRDGTVKVWDPRQKDD PVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRNMSLRWETNIKNG VCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTKGFASVSEKAHKSTVWQVRHLPQN RELFLTAGGTGSLHLWKYEYPIQRSKKDSEGVEMGVAGSVSLLQNVTLSTQPISSLDWSP DKRGLCICSSFDQMVR-------------------VLIVTKLHKI------ >O_anatinus_ENSOANP00000013326 ------------------------------------------------------------ --------------------------------------------MEKI------------ --------W--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N W-NSF------P-------------PHM-T-----------------------------G ------------------L-IDADEIKRLGKRFKKLDLDNS------G-----SLSVEEF MSL-----PELQQNPLVQRVIDIFDTDG--N---------GEVDFKEFIEGVSQFSVKGD ----------------KEQKLRFAFRIY-DMDKDGYISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TIINADKDGD--GR---------ISFEEFCAV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VGGL-DIH---KKMV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VD-------------------V--------------- >B_taurus_ENSBTAP00000014038 ------------------------------------------------------------ -----------------------------------------------M------------ --------G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-ASY------P-------------LEM-C-----------------------------S ------------------H-FDADEIKRLGKRFKKLDLDNS------G-----SLSVEEF MSL-----PELQQNPLVQRVIDIFDTDG--N---------GEVDFKEFIEGVSQFSVKGD ----------------KEQKLRFAFRIY-DMDKDGYISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TIINADKDGD--GR---------ISFEEFCAV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VGGL-DIH---KKMV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VD-------------------V--------------- >D_rerio_ENSDARP00000091642 ------------------------------------------------------------ -----------------------------------------------M------------ --------G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-ASY------P-------------LEM-C-----------------------------S ------------------H-FDADEIKRLGKRFKKLDLDNS------G-----SLSVEEF MSL-----PELQQNPLVQRVIDIFDTDG--N---------GEVDFKEFIEGVSQFSVKGD ----------------KEQKLRFAFRIY-DMDKDGYISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TIINADKDGD--GR---------ISFEEFCAV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VGGL-DIH---KKMV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VD-------------------V--------------- >G_aculeatus_ENSGACP00000025992 ------------------------------------------------------------ -----------------------------------------------M------------ --------G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-ASY------A-------------LDM-C-----------------------------S ------------------H-FDADEIKRLGKRFKKLDLDNS------G-----SLSVEEF MSL-----PELQQNPLVQRVIDIFDTDG--N---------GEVDFKEFIEGVSQFSVKGD ----------------KEQKLRFAFRIY-DMDKDGYISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TIINADKDGD--GR---------ISFEEFCAV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VGGL-DIH---KKMV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VD-------------------V--------------- >G_gallus_ENSGALP00000014233 ------------------------------------------------------------ -----------------------------------------------M------------ --------G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-ASY------P-------------LEM-C-----------------------------S ------------------H-FDADEIKRLGKRFKKLDLDNS------G-----SLSVEEF MSL-----PELQQNPLVQRVIDIFDTDG--N---------GEVDFKEFIEGVSQFSVKGD ----------------KEQKLRFAFRIY-DMDKDGYISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TIINADKDGD--GR---------ISFEEFCAV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VGGL-DIH---KKMV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VD-------------------V--------------- >M_musculus_ENSMUSP00000099944 ------------------------------------------------------------ -----------------------------------------------M------------ --------G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-ASY------P-------------LEM-C-----------------------------S ------------------H-FDADEIKRLGKRFKKLDLDNS------G-----SLSVEEF MSL-----PELQQNPLVQRVIDIFDTDG--N---------GEVDFKEFIEGVSQFSVKGD ----------------KEQKLRFAFRIY-DMDKDGYISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TIINADKDGD--GR---------ISFEEFCAV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VGGL-DIH---KKMV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VD-------------------V--------------- >T_nigroviridis_ENSTNIP00000012713 ------------------------------------------------------------ -----------------------------------------------M------------ --------G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-ASY------P-------------LEM-C-----------------------------S ------------------H-FDADEIKRLGKRFKKLDLDNS------G-----SLSVEEF MSL-----PELQQNPLVQRVIDIFDTDG--N---------GEVDFKEFIEGVSQFSVKGD ----------------KEQKLRFAFRIY-DMDKDGYISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TIINADKDGD--GR---------ISFEEFCAV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VGGL-DIH---KKMV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VD-------------------V--------------- >T_rubripes_ENSTRUP00000002123 ------------------------------------------------------------ -----------------------------------------------M------------ --------G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-ASY------A-------------LDM-C-----------------------------S ------------------H-FDADEIKRLGKRFKKLDLDNS------G-----SLSVEEF MSL-----PELQQNPLVQRVIDIFDTDG--N---------GEVDFKEFIEGVSQFSVKGD ----------------KEQKLRFAFRIY-DMDKDGYISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TIINADKDGD--GR---------ISFEEFCAV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VGGL-DIH---KKMV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VD-------------------V--------------- >X_tropicalis_ENSXETP00000037793 ------------------------------------------------------------ ------------------------------------------------------------ --------G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-ASY------P-------------LEM-C-----------------------------S ------------------H-FDADEIKRLGKRFKKLDLDNS------G-----SLSVEEF MSL-----PELQQNPLVQRVIDIFDTDG--N---------GEVDFKEFIEGVSQFSVKGD ----------------KEQKLRFAFRIY-DMDKDGYISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TIINADKDGD--GR---------ISFEEFCAV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VGGL-DIH---KKMV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VD-------------------V--------------- >M_domestica_ENSMODP00000004413 ------------------------------------------------------------ --------------------------------------------FKFQ------------ --------G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-ASY------P-------------LEM-C-----------------------------S ------------------H-FDADEIKRLGKRFKKLDLDNS------G-----SLSVEEF MSL-----PELQQNPLVQRVIDIFDTDG--N---------GEVDFKEFIEGVSQFSVKGD ----------------KEQKLRFAFRIY-DMDKDGYISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TIINADKDGD--GR---------ISFEEFCAV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VGGL-DIH---KKMV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VD-------------------V--------------- >T_nigroviridis_ENSTNIP00000007154 ------------------------------------------------------------ -----------------------------------------------Q------------ --------G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-ASY------A-------------LDM-C-----------------------------S ------------------H-FDADEIKRLGKRFKKLDLDNS------G-----SLSVEEF MSL-----PELQQNPLVQRVIDIFDTDG--N---------GEVDFKEFIEGVSQFSVKGD ----------------KEQKLRFAFRIY-DMDKDGYISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TIINADKDGD--GR---------ISFEEFCAV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VGGL-DIH---KKMV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VD-------------------V--------------- >E_caballus_ENSECAP00000007559 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------M-C-----------------------------S ------------------H-FDADEIKRLGKRFKKLDLDNS------G-----SLSVEEF MSL-----PELQQNPLVQRVIDIFDTDG--N---------GEVDFKEFIEGVSQFSVKGD ----------------KEQKLRFAFRIY-DMDKDGYISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TIINADKDGD--GR---------ISFEEFCAV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VGGL-DIH---KKMV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VD-------------------V--------------- >D_rerio_ENSDARP00000022350 ------------------------------------------------------------ ------------------------------------------------------------ --------G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-ASY------P-------------LEM-C-----------------------------S ------------------H-FDADEIKRLGKRFKKLDLDNS------G-----SLSVEEF MSL-----PELQQNPLVQRVIDIFDTDG--N---------GEVDFKEFIEGVSQFSVKGD ----------------KEMKLRFAFRIY-DMDKDGYISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TIINADKDGD--GR---------ISFEEFCAV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VGGL-DIH---KKMV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VD-------------------V--------------- >C_elegans_F55C10.1 ------------------------------------------------------------ -----------------------------------------------M------------ --------G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------A D-ASL------P-------------MEM-C-----------------------------S ------------------N-FDAYELRRLTRRFKKLDVDGS------G-----SLSVEEF MSL-----PELQQNPLVQRVIDIFDEDG--N---------GEVDFREFIQGISQFSVKGD ----------------KNTKLKFAFRIY-DMDRDGFISNGELFQVLKM---MVGN----N --LKDSQLQQIVDK----TILFHDKDGD--GK---------ISFQEFCDV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VEHT-EVH---KKMV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LE------------------NI--------------- >D_melanogaster_FBpp0088004 ------------------------------------------------------------ -----------------------------------------------M------------ --------G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-TSL------P-------------MEM-C-----------------------------S ------------------N-FDADEIRRLGKRFRKLDLDNS------G-----ALSVDEF MSL-----PELQQNPLVQRVIDIFDADG--N---------GEVDFKEFIQGVSQFSVKGD ----------------KLSKLRFAFRIY-DMDNDGYISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TIGFADKDED--GK---------ISFDEFCSV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VGNT-DIH---KKMV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VD-------------------V--------------- >D_melanogaster_FBpp0070731 ------------------------------------------------------------ -----------------------------------------------M------------ --------G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-TSL------P-------------MDM-C-----------------------------S ------------------N-FDADEIRRLGKRFRKLDLDNS------G-----ALSIDEF MSL-----PELQQNPLVQRVIDIFDADG--N---------GEVDFKEFIQGVSQFSVRGD ----------------KLSKLRFAFRIY-DMDNDGYISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TICFADKDED--GK---------ISFDEFCSV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VGNT-DIH---KKMV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VD-------------------V--------------- >O_cuniculus_ENSOCUP00000014388 ------------------------------------------------------------ ----------------------------------------------TM------------ --------G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-ASY------P-------------AEM-C-----------------------------S ------------------H-FDHDEIRRLGKRFRKLDLDKS------G-----TLSVEEF MSL-----PELQQNPLVKRVIDIFDMDG--N---------GEVDFKEFILGTSQFSVKGN ----------------EEQKLRFAFSIY-DMDKDGYISNGELFQVLKM---MVGN----N --LRDWQLQELVDK----TIIILDKDGD--GK---------ISFEEFSTV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VRGL-EFH---KKLV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VI-------------------V--------------- >G_gorilla_ENSGGOP00000016332 ------------------------------------------------------------ --------------------------------------------MSTM------------ --------G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-ASY------P-------------AEM-C-----------------------------S ------------------H-FDNDEIKRLGRRFKKLDLDKS------G-----SLSVEEF MSL-----PELRHNPLVRRVIDVFDTDG--D---------GEVDFKEFILGTSQFSVKGD ----------------XEQKLRFAFSIY-DMDKDGYISNGELFQVLKM---MVGN----N --LTDWQLQQLVDK----TIIILDKDGD--GK---------ISFEEFSAV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VRDL-EIH---KKLV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LI-------------------V--------------- >H_sapiens_ENSP00000363939 ------------------------------------------------------------ --------------------------------------------MSTM------------ --------G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-ASY------P-------------AEM-C-----------------------------S ------------------H-FDNDEIKRLGRRFKKLDLDKS------G-----SLSVEEF MSL-----PELRHNPLVRRVIDVFDTDG--D---------GEVDFKEFILGTSQFSVKGD ----------------EEQKLRFAFSIY-DMDKDGYISNGELFQVLKM---MVGN----N --LTDWQLQQLVDK----TIIILDKDGD--GK---------ISFEEFSAV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VRDL-EIH---KKLV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LI-------------------V--------------- >A_aegypti_AAEL010470-PA ------------------------------------------------------------ -----------------------------------------------M------------ --------G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-TSL------P-------------MEL-C-----------------------------S ------------------N-FDADEIRRLGKRFKKLDLDNS------G-----ALSIDEF MSL-----PELQQNPLVQRVIDIFDADG--N---------GEVDFKEFIQGVSQFSVKGD ----------------KLSKLKFAFRIY-DMDNDGFISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TIVFADKDED--GK---------ISFDEFCSV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VGNT-DIH---KKMV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VD-------------------V--------------- >R_norvegicus_ENSRNOP00000007290 ------------------------------------------------------------ -----------------------------------------------M------------ --------G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-ASY------H-------------SEM-G-----------------------------T ------------------H-FDHDEIKRLGRSFKKMDLDKS------G-----SLSVDEF MSL-----PELQQNPLVGRVIDIFDTDG--N---------GEVDFREFIVGTSQFSVKGD ----------------EEQKLRFAFRIY-DMDNDGFISNGELFQVLKM---MVGN----N --LKDWQLQQLVDK----SILVLDKDGD--GR---------ISFEEFRDV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VRTM-EIH---KKLV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VF-------------------VDHGQED--------- >M_musculus_ENSMUSP00000029991 ------------------------------------------------------------ -----------------------------------------------M------------ --------G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N E-ASY------Q-------------TEL-C-----------------------------N ------------------H-FDQEEIRRLGKSFRKLDLDKS------G-----SLSIEEF MRL-----PELQQNPLVGRVIDIFDTDG--N---------GEVDFHEFIVGTSQFSVKGD ----------------EEQKLRFAFRIY-DMDNDGFISNGELFQVLKM---MVGN----N --LKDWQLQQLVDK----SILVLDKDGD--GR---------ISFEEFSDV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VKTM-EIH---KKLV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VF-------------------VEHGQEDLKA------ >S_cerevisiae_YKL190W ------------------------------------------------------------ -----------------------------------------------M------------ --------G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------A A-PSK------I-------------VDG-LL--------------------------EDT ------------------N-FDRDEIERLRKRFMKLDRDSS------G-----SIDKNEF MSI-----PGVSSNPLAGRIMEVFDADN--S---------GDVDFQEFITGLSIFSGRGS ----------------KDEKLRFAFKIY-DIDKDGFISNGELFIVLKI---MVGS----N --LDDEQLQQIVDR----TIVENDSDGD--GR---------LSFEEFKNA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------IETT-EVA---KSLT------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LQ-------------------YDV------------- >M_domestica_ENSMODP00000019214 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S A-HS----MSEE-------------VRE-LV--------------------------SKT ------------------G-FSSEQIEQLHRRFKQLSGGQP------------TIRKENF NNI-----PDLELNPIRSKIIHAFFDNR--NLRKAPNGLADEINFEDFLIIMSYFRPIEP ------NMDEEQLERCRKEKLRFLFHMY-DSDSDGRITLEEYRNVVEE---LLSG----N PHIGKESARSIADG----AMMEAASICV--GQMQPDQVYEGITFDDFLKM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------WQGI-DIE---TKMH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VR-------------------FLNMDAIAL-CH---- >H_sapiens_ENSP00000376328 ------------------------------------------------------------ ---------MRPRSGPTRNPRLRAFAGVPTRGRT----RGQSRRCAAEASAGPERDARPG APAAGTM-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------A A-HS----ASEE-------------VRE-LE--------------------------GKT ------------------G-FSSDQIEQLHRRFKQLSGDQP------------TIRKENF NNV-----PDLELNPIRSKIVRAFFDNR--NLRKGPSGLADEINFEDFLTIMSYFRPIDT ------TMDEEQVELSRKEKLRFLFHMY-DSDSDGRITLEEYRNVVEE---LLSG----N PHIEKESARSIADG----AMMEAASVCM--GQMEPDQVYEGITFEDFLKI---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------WQGI-DIE---TKMH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VR-------------------FLNMETMAL-CH---- >P_pygmaeus_ENSPPYP00000005704 ------------------------------------------------------------ ---------MRPRSGPTRNPRLRAFAG-PTRGRTRGQPRGQSRRCAAEASAGPERDARPG APAAGTM-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------A A-HS----ASEE-------------VRE-LE--------------------------GKT ------------------G-FSSDQIEQLHRRFKQLSGDQP------------TIRKENF NNV-----PDLELNPIRSKIVRAFFDNR--NLRKGPSGLADEINFEDFLTIMSYFRPIDT ------TMDEEQVELSRKEKLRFLFHMY-DSDSDGRITLEEYRNVVEE---LLSG----N PHIEKESARSIADG----AMMEAASVCM--GQMEPDQVYEGITFEDFLKI---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------WQGI-DIE---TKMH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VR-------------------FLNMETMAL-CH---- >A_gambiae_AGAP004298-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KKLDLDNS------G-----ALSIDEF MSL-----PELQQNPLVQRVIDIFDADG--N---------GEVDFKEFIQGVSQFSVKGD ----------------KLSKLKFAFRIY-DMDNDGYISNGELFQVLKM---MVGN----N --LKDTQLQQIVDK----TIVFADKDED--GK---------ISFDEFCSV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VGNT-DIH---KKMV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VD-------------------V--------------- >A_carolinensis_ENSACAP00000016199 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S S-HS----MSEE-------------IRE-LA--------------------------DKT ------------------G-FTTDQIENLHRRFKQLSGDQP------------TIRKENF DRI-----PDLEFNPIRSKIVHAFFDRR--NLQEASVGQVDEINFEDFLTIMSNFRPIEM ------NMDEEQLDRFRKQKLKFLFHMY-DADSDGKITLQEYRNVVQE---MLSG----N PHLDKESVRSIADG----AMMEAATICV--GQMEPDQVYEGITFEDFLKI---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------WQGI-DLE---TKMH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VR-------------------FLTMEPIAM-CY---- >M_musculus_ENSMUSP00000031304 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------A A-HS----ASEE-------------VRE-LE--------------------------GKT ------------------G-FSSDQIEQLHRRFKQLSGDQP------------TIRKENF NNV-----PDLELNPIRSKIVRAFFDNR--NLRKGSSGLADEINFEDFLTIMSYFRPIDT ------TLGEEQVELSRKEKLKFLFHMY-DSDSDGRITLEEYRNVVEE---LLSG----N PHIEKESARSIADG----AMMEAASVCV--GQMEPDQVYEGITFEDFLKI---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------WQGI-DIE---TKMH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLNMETIAL-CH---- >R_norvegicus_ENSRNOP00000001490 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------A A-HS----ASEE-------------VRE-LE--------------------------GKT ------------------G-FSSDQIEQLHRRFKQLSGDQP------------TIRKENF NNV-----PDLELNPIRSKIVRAFFDNR--NLRKGSSGLADEINFEDFLTIMSYFRPIDT ------TLGEEQVELSRKEKLKFLFHMY-DSDSDGRITLEEYRNVVEE---LLSG----N PHIEKESARSIADG----AMMEAASVCV--GQMEPDQVYEGITFEDFLKI---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------WQGI-DIE---TKMH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLNMETIAL-CH---- >M_mulatta_ENSMMUP00000023001 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------A A-HS----ASEE-------------VRE-LE--------------------------GKT ------------------G-FSSDQIEQLHRRFKQLSGDQP------------TIRKENF NNV-----PDLELNPIRSKIVRAFFDNR--NLRKGSSGLADEINFEDFLTIMSYFRPIDT ------TMDEEQVELSRKEKLRFLFHMY-DSDSDGRITLEEYRNVVEE---LLSG----N PHIEKESARSIADG----AMMEAASVCM--GQMEPDQVYEGITFEDFLKI---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------WQGI-DIE---TKMH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VR-------------------FLNMETMAL-CH---- >C_familiaris_ENSCAFP00000013672 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K L-YC----QGDR-------------INN-LR--------------------------GAS ------------------S-VSSDQIEQLHRRFKQLSGDQP------------TIRKENF NNV-----PDLELNPIRSKIVRAFFDNR--NLRKGSSGLADEINFEDFLTIMSYFRPIDT ------TMDEEQVQLCRKEKLRFLFHMY-DSDSDGRITLEEYRNVVEE---LLSG----N PHIEKESARSIADG----AMMEAASVCV--GQMEPDQVYEGITFDDFLKI---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------WQGI-DIE---TKMH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VR-------------------FLNMETIAL-CH---- >E_caballus_ENSECAP00000009132 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SSDQIEQLHRRFKQLSGDQP------------TIRKENF NNV-----PDLDLNPIRSKIIRAFFDNR--NLRKGPSGVADEINFEDFLTIMSYFRPIDI ------TMDEEQVQLCRKEKLRFLFHMY-DSDSDGRITLEEYRNVVEE---LLSG----N PHIEKESARSIADG----AMMEAASVCV--GQMEPDQVYEGITFDDFLKI---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------WQGI-DIE---TKMH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VR-------------------FLNVEAMAL-CH---- >T_nigroviridis_ENSTNIP00000011927 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------A L-QS--SPAPRD-------------QAD-LA--------------------------EKT ------------------G-FSLEQIAVLHKRFKQLSHNEE------------TLRREHF KAI-----PDLACNPIRSQIIQAFFDRR--NFHQNDDGTVEEISFEEFLVVMSHFRPPSQ ------HMSEEQRESVRKEKLRFLFNMH-DTDNDGMITLEEYRHVVEE---LLSR----S GALGKETAKSIADA----AMLEVASISM--GHMEPDEFYEGITFEHFLKL---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LGSF-EIE---SKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLNMDASTL-CA---- >O_latipes_ENSORLP00000001124 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------A A-TT---RIGQQ-------------DPE-LV--------------------------DRT ------------------G-FSPEQINNLHKRFLQLSGNKD------------TISRENL NDI-----PALTYNPIKSQIIEAFFDKR--NQHDSEVGSLEEITFEQFLMVMSHFRPPTL ------EMTAEEKQAMRKEKLRFLFNMH-DTDGDGKITLEEYRKVVEE---LLS-----S GSIEQESAKEITDA----AMLEVASTNV--PHMGPEDFYEGITFEHFEQI---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LKGL-EME---SRMH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLD--TATVHCGKS-- >T_rubripes_ENSTRUP00000041977 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------A S-QT---RSDHK-------------YQN-LV--------------------------EKT ------------------G-FSLEQIKNLHKRFQQLSGNEE------------TISKENL NSI-----PALANNPIRKQIVDAFFDKR--NQHQNEVGSFHEISFEQFLMVMSHFRPPTL ------KTTEEEKEALRKEKLRFLFNMH-DTDNDGTITLEEYRKVVEE---LLSK----S GAIGQEAAKTIADA----AMLEVASTNV--PHMAPDDFYEGITFEHFEQI---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LKGL-EME---SRMH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLDVDTTTMRCGK--- >P_troglodytes_ENSPTRP00000009339 ------------------------------------------------------------ ---------MRPRSGPTRNPRLRAFAGVPTRGRT----RGQSRRCAAEASAGPERDARPG APAAGTM-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------A A-HS----ASEE-------------VRE-LE--------------------------GKT ------------------G-FSSDQIEQLHRRFKQLSGDQP------------TIRKENF NNV-----PDLELNPIRSKIVRAFFDNR--NLRKGPSGLADEINFEDFLTIMSYFRPIDT ------TMDEEQVELSRKEKLRFLFHMY-DSDSDGRITLEEYRNV--------------- ----KWSRSCCRET----LTSRRSPLAP--SPTGP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >O_latipes_ENSORLP00000010227 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S L-QS--SPSHQD-------------YVD-LA--------------------------EKT ------------------G-FSFEQISILHKRFKQLSHNED------------KLRREHF GQI-----TDLHANPIREQIVEAFFDRR--NFYQEIEEPVSEISFENFLVVMSNFRPPSD ------NMSQEKLVKVRKEKLRFLFNMH-DTDKDGTITLEEYRHVVEE---LLSY----Y EALETETARGIADA----AMLEVASITR--GHMEPDEFYEGITFEHFLKL---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LEGF-DIE---SRMN------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FMNMDTTTL-CKL--- >C_elegans_F30A10.1 MYSQLICVSNFYVSSFSLYGGPHLPFLLSHRPGPSVPSSCSFCIFFFAFSPRGLPSNVTP FSDSKPPQFVYYFLVCLPPQTHSHFLLDFRGARG----LTEQNFIFNNRQSGDQMGNNAS SLSELNL-F--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S K-GG--VFTREQ-------------LDE-YQ--------------------------DCT ------------------F-FTRKDIIRLYKRFYALNPHKVPTNMQGNRPAITTLTFEEV EKM-----PELKENPFKRRICEVFSEDG--R---------GNLSFDDFLDMFSVFSEMAP ----------------LQLKLKYAFRIY-DYDGDELLGHDDLSKMIRS---LTRD----E --LSDVEVEFIIER----IIEEADLDGD--SS---------INFAEFEHV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VSRSPDFI---RTFH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------I---------------- >T_nigroviridis_ENSTNIP00000018679 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------A S-QT---RSEHK-------------YQS-LV--------------------------EKT ------------------G-FSLEQIKNLHKRFQQLSRNEE------------TISREDL NSI-----PALANNPIRKQIVDAFFDKR--NQHQNEVGSLQEISFEQFLMVMSHFRPPTL ------KTTEEEKEALRKEKLRFLFNMH-DTDHDGTITLEEYRKVVEE---LLSK----S GAIGQEAAQAIADA----AMLEVASTNV--PHMDPDDFYEGITFEHFEQI---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LKGL-EME---SRMH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLDVDTTTMRCGKSSS >M_musculus_ENSMUSP00000064132 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------A S-LS----SKEEWERESRTDLWWAHIQE-VL--------------------------NKC ------------------D-FSWEQIKQLHQRFRLLSGDQP------------TLQPESF DNI-----LDLEFNPIRSRIVRAFFDNR--NLGKGTSGLAEEITFQDFLTIISYFRPLRP ------SLNKEEAEQNRKDKMRFLFNMY-DQDGDGIITLQEYRRVVES---LLSA----H PQVERDTVRSVANAIAQGALKEAARASD--QPLMAGQQYEGITFEDFVKT---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------WKSL-ELE---VKMQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VS-------------------FLNLEATVL-CQ---- >G_aculeatus_ENSGACP00000018615 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------A S-QT---RPEHR-------------HQD-LA--------------------------DRT ------------------G-FSLEQIKNLHKRFQQLSGDED------------TISKENL ESI-----PTLANNPIRKQIIGAFFDKR--NQHRGEAGSCDQIGFEQFLMVMSHFRPPTL ------KMTAEEKEAMRREKLRFLFNMH-DTDNDGTITLVEYRKVVEE---LLSK----S GSIGQEAAEAIADA----AMLEVASTNV--PTMGPDDFYEGITFEHFEQI---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LKGL-EME---SRMH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLDVDTTTMRCGKSTS >D_rerio_ENSDARP00000035258 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------A A-QS--GGQAQK-------------YQD-LA--------------------------DKT ------------------G-FSTEQIRKLHSRFQYLTQDED------------TLRREHL ENL-----TNLALNPIKRQIIEAFFDKR--NLGQNEKGCLQEIGFEEFVTVLSVFRPTKP ------RTAEDKKKTIKEEKLRFLFNMH-DTDNDGVITLDEYRRVVEE---LLSS----Y ETIEAETAKAISDA----AMLEVASVTV--GRMSPDEFYEGITFEQFMQI---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LKDI-EIE---TKMN------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VH-------------------FWNLDTRTMHCGK--- >R_norvegicus_ENSRNOP00000026268 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------V S-HS----SREEWERESRTDLWWAHIQEAFM--------------------------KKC ------------------D-FSWDQIKQLHQRFRLLSGDQP------------TLRPENF DNV-----LDLEFNPIRSRIVRAFFDNR--NLGKGTSGLAEEITFQDFLTIISYFRPLEP ------RPNKEEAEQYRKEKMQFLFNMY-DQDGDGIITLQEYRRVVED---LLSA----N PQAETATVRSVANSIARVALMEASRASD--QPLNEDEPYEGITFEDFFKT---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------WQSL-ELE---VKMQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VS-------------------FLNLQAMAF-CQ---- >D_rerio_ENSDARP00000041503 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S F-QS--LPDDHQ-------------YRT-LS--------------------------QKT ------------------G-FSLEQIGILHNRFKQLSQNED------------TLRRDDL KTI-----QDLESNPIRSQIIEAFFDKR--NFQKDATGSVQEIGFEEFLTVMSYFRAPAH ------QITEEQREEIRRAKLRFLFNMH-DTDNDGTITLEEYRHVVEE---LLSR----S GALGRETAKGIADA----AMLEVASITV--GPMAPDEFYEGITFEQFLKI---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LKGV-EIE---TRMH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLNMDTTVL-CKK--- >T_rubripes_ENSTRUP00000031474 ------------------------------------------------------------ ------------------------------------------------------------ ------YKG--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G L-NNR-SDCKRS-------------KRR-WW--------------------------QQE --------MGLFYCSSVFS-VSIEQIAVLHKRFRQLSHNDE------------KLRREHF MAI-----PDLACNPIRSQIIQAFFDRR--NFHQKDDGTVEEISFEQFLVVMSHFRPPSP ------HMTEEQRESVRRDKLRFLFNMH-DTDNDGMITLEEYRHVVEE---LLSR----S GALGKETAKSIADA----AMLEVASISM--GHMEPDEFYEGITFEHFLKL---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LGSF-EIE---SKMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR-------------------FLNMDTFTL-CK---- >G_gallus_ENSGALP00000013348 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S A-QS----VPPE-------------MRA-LA--------------------------ERT ------------------G-FTSEQIEQLHRRFKQLSHNRK------------TIRKEDF DTI-----PDLEINPIRAR-----------------------------XTIMSYFRPIEM ------DMDEERLESFRKEKLKFLFHMY-DADYDGIITLQEYKNVLDE---LMSG----N PHLEKESLRAIAEG----AMLEAASACM--ARTGPDEVYEGITFEDFLKV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------WKGI-DIE---TKMH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VR-------------------FLTMEAIAH-CY---- >D_melanogaster_FBpp0070199 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S V-GSR-QLNPVQ-------------LCD-HQ--------------------------QAT ------------------G-LSAEQLEQLHTRFRSLDRHQR------G-----YLTPTDL LRI-----PQLSLNPLHRQIIDGFFPSRDPS---------ARIGFKQFVDTCSTILVPQF ------GRGSVRRRDGRVQKLQLLSKMF-DTRRSGCITRSDFRQIMRS---IVNLAWSQQ --QDQERQEGLSEN----RLPEVEAELQLLEHQAFGFCCDHISYGEFEKR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LFSV-DVD---RRLS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IAKWLEDDDEADAE------MVLPVGSGP-------- >A_aegypti_AAEL002221-PA ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------Q V-KS--QFSEEE-------------LQD-YE--------------------------DLT ------------------Y-FTKKEILFAHKKFKALAPEKV------GHNKNARLAMTKI LQY-----PELRVNPFGDRICKVFSSSN--N---------GEISFEDFLDMMSVFSDAAP ----------------KSVKAEHAFRIF-DFDGDDMIGKNDLKQVIQR---LTGY----N NALNESDIDQLITN----ILEEADLDDD--GA---------LSFAEFEHI---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------IDKSSDFT---NSFR------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------L---------------- >A_gambiae_AGAP008474-PA ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------Q A-NS--QFSEDE-------------LQD-YE--------------------------DLT ------------------Y-FTKKEILYAHKKFKNLAPEKV------GHNKNAKLSMSKV LEY-----PELKANPFGDRICKVFSSSN--D---------GDITFEDFLDMMSVFSDAAP ----------------KAVKAEHAFRIY-DFDGDDMIGRNDLKQVIQR---LVDY----N SDLGHNDIDQLINN----ILEEADLDDD--GA---------LSFAEFEHI---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------IDKSSDFI---NSFR------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------L---------------- >D_melanogaster_FBpp0071445 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-VV--TFTEQE-------------LDD-YQVSDQSDEVHFHTANFSSCIAGPQIGKDCT ------------------F-FTRKEILRVHKRFRELRPDLVPRQMTEGQASSVKVPCECI EKM-----PELRENPFRRRICEAFSRDG--Q---------GNLSFEDFLDALSVFSEQAP ----------------RDIKVFYAFKIY-DFDQDGFIGHADLMSCLTT---MTKN----E --LSPEEHQQIADK----VIEEADVDGD--GK---------LSILEFEHV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ILRAPDFL---STFH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------I---------------- >G_aculeatus_ENSGACP00000023145 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-QT--TFTDEQ-------------LEA-FQ--------------------------DCT ------------------F-FTRKEILRLHGRYRELAPHLVPLDY--TNNPDIRVPPTLI VTM-----PEFKENPFRDRIVETFSEDG--N---------GNLSFNDFVDMFSALCETSP ----------------RELKTIYAFKIY-DFNRDNFICKEDLKKTLNK---LTKG----E --LTPEEVTLVCNK----SMEEADLDGD--SK---------LSFSDFENM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------VSKAPDFL---SNFH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VR------------------I---------------- >G_gallus_ENSGALP00000005238 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-QT--IFTDEQ-------------LDA-YQ--------------------------DCT ------------------F-FTRKEILRLHGRYHEMAPNVVPMDY--TKDPDVKLPMQLI INM-----PELKENPFKERIVESFSEDG--E---------GSLSFNDFVDMFSVLSEMAP ----------------RELKAIYAFKIY-DFNTDNFICKADLEKTLNK---LTRE----E --LTAEEITLVCEK----VIEEADMDGD--GK---------LGFADFENM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ISKAPDFL---STFH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------I---------------- >T_guttata_ENSTGUP00000003345 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-QT--IFTDEQ-------------LDA-YQ--------------------------DCT ------------------F-FTRKEILRLHGRYHEMAPNVVPMDY--TKDPDVKLPMQLI INM-----PELKENPFKERIVESFSEDG--E---------GSLSFNDFVDMFSVLSEMAP ----------------RELKAIYAFKIY-DFNTDNFICKADLEKTLNK---LTRE----E --LTAEEITLVCEK----VIEEADMDGD--GK---------LGFADFENM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ISKAPDFL---STFH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------I---------------- >O_latipes_ENSORLP00000023695 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-QT--TFTEEQ-------------LEA-YQ--------------------------DCT ------------------Y-FTRKEILRLHGRFRELAPHLVPLDY--TNNPDVKVPLTLI VTM-----PELKENPFRERIVETFSEDG--Q---------GNLSFNDFVDMFSALCEASP ----------------RELKTIYAFKIY-DFNRDNFICKEDMDKTLNK---LTKG----E --LTAEEVALVCNK----AIEEADLDGD--SK---------LSFADFENM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ISKAPDFLRINKNLQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GRKELKKSSGLKSEHELLWER---------------- >H_sapiens_ENSP00000258930 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-QT--IFTEEQ-------------LDN-YQ--------------------------DCT ------------------F-FNKKDILKLHSRFYELAPNLVPMDY--RKSPIVHVPMSLI IQM-----PELRENPFKERIVAAFSEDG--E---------GNLTFNDFVDMFSVLCESAP ----------------RELKANYAFKIY-DFNTDNFICKEDLELTLAR---LTKS----E --LDEEEVVLVCDK----VIEEADLDGD--GK---------LGFADFEDM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------IAKAPDFL---STFH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------I---------------- >M_mulatta_ENSMMUP00000012968 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-QT--IFTEEQ-------------LDN-YQ--------------------------DCT ------------------F-FNKKDILKLHSRFYELAPNLVPMDY--RKSPIVHVPMSLI IQM-----PELRENPFKERIVAAFSEDG--E---------GNLTFNDFVDMFSVLCESAP ----------------RELKANYAFKIY-DFNTDNFICKEDLELTLAR---LTKS----E --LDEEEVVLVCDK----VIEEADLDGD--GK---------LGFADFEDM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------IAKAPDFL---STFH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------I---------------- >P_troglodytes_ENSPTRP00000012541 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-QT--IFTEEQ-------------LDN-YQ--------------------------DCT ------------------F-FNKKDILKLHSRFYELAPNLVPMDY--RKSPIVHVPMSLI IQM-----PELRENPFKERIVAAFSEDG--E---------GNLTFNDFVDMFSVLCESAP ----------------RELKANYAFKIY-DFNTDNFICKEDLELTLAR---LTKS----E --LDEEEVVLVCDK----VIEEADLDGD--GK---------LGFADFEDM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------IAKAPDFL---STFH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------I---------------- >T_rubripes_ENSTRUP00000032101 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-QT--IFTDEQ-------------LDA-YQ--------------------------DCT ------------------F-FTRKEILRLHGRYHELAPHLVPMDY--TNDPDCKLPLALI VNM-----PELKENPFRNRIVEAFSEDG--M---------GNLSFNEFVDMFSVLSETAP ----------------RELKAIYAFKIY-DFNVDNFLCKEDLEKTLNK---LTKE----E --LTPEEVDLVCEK----TIEEADLDGD--NK---------LSFADFENM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ISRAPDFL---STFH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------I---------------- >A_carolinensis_ENSACAP00000008237 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-QT--IFTDEQ-------------LDA-YQ--------------------------DCS ------------------F-FTRKEILRLHERYHELAPHIVPMDY--TRNPDVKVPKQLI INM-----PELMENPFKERIVHSFSEDE--E---------GSLSFNDFVDMFSALSETAP ----------------RELKAVYAFKVY-DFNTDNFICKSDLEQTLNK---LTKE----D --LTEEEITLVCEK----VIEEADMDAD--GK---------LGFADFENM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ISKAPDFL-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >O_latipes_ENSORLP00000009324 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-QT--IFTDEQ-------------LDA-YQ--------------------------DCT ------------------F-FTRKEILRLHGRYHELAPHLVPMDY--TNEPDCKIPLALI VNM-----PELKENPFRDRIVESFSEDG--M---------GNLSFNEFVDMFSVLSEMAP ----------------RELKAIYAFKIY-DFNVDNYLCKEDLEKTLNK---LTKE----E --LTPEEVELVCEK----TIVEADLDGD--SK---------LSYADFENM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ITRAPDFL---STFH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------I---------------- >C_familiaris_ENSCAFP00000021614 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-QT--IFTEEQ-------------LDN-YQ--------------------------DCT ------------------F-FNKKDILKLHARFYELAPNLVPMDY--RKSPIVHVPMSLI IQM-----PELRENPFKERIVEAFSEDG--E---------GNLTFNDFVDMFSVLCESAP ----------------RELKANYAFKIY-DFNTDNFICKEDLERTLAR---LTKS----E --LDEDEVVLVCDK----VIEEADLDGD--GK---------LGFADFEDM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------IAKAPDFL---STFH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------I---------------- >E_caballus_ENSECAP00000008481 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-QT--IFTEEQ-------------LDN-YQ--------------------------DCT ------------------F-FNKKDILKLHARFYELAPNLVPMDY--RKSPIVHVPMSLI IQM-----PELRENPFKERIVEAFSEDG--E---------GNLTFNDFVDMFSVLCESAP ----------------RELKANYAFKIY-DFNTDNFICKEDLERTLAR---LTKS----E --LDEDEVVLVCDK----VIEEADLDGD--GK---------LGFADFEDM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------IAKAPDFL---STFH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------I---------------- >M_musculus_ENSMUSP00000038527 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-QT--IFTEEQ-------------LDN-YQ--------------------------DCT ------------------F-FNKKDILKLHARFYELAPNLVPMDY--RKSPIVHVPMSLI IQM-----PELRENPFKERIVEAFSEDG--E---------GNLTFNDFVDMFSVLCESAP ----------------RELKANYAFKIY-DFNTDNFICKEDLEMTLAR---LTKS----E --LEEDEVVLVCDK----VIEEADLDGD--GK---------LGFADFEDM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------IAKAPDFL---STFH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------I---------------- >B_taurus_ENSBTAP00000053746 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------R--NLRKGTSGLADEINFEDFLTIMSYFRPIDT ------TMDEEQVQLCRKEKLRFLFHMY-DSDSDGRITLEEYRNVVEE---LLSG----N PHIEKESARSIADG----AMMEAASVCV--GQMEPDQVYEGITFDDFLKI---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------WQGI-DIE---TKMH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VR-------------------FLNMETIAL-CH---- >R_norvegicus_ENSRNOP00000013623 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-QT--IFTEEQ-------------LDN-YQ--------------------------DCT ------------------F-FNKKDILKLHARFYELAPNLVPMDY--RKSPIVHVPMSLI IQM-----PELRENPFKERIVEAFSEDG--E---------GNLTFNDFVDMFSVLCESAP ----------------RELKANYAFKIY-DFNTDNFICKEDLELTLAR---LTKS----E --LDEDEVVLVCDK----VIEEADLDGD--GK---------LGFADFEDM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------IAKAPDFL---STFH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------I---------------- >G_aculeatus_ENSGACP00000013519 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-QT--IFTDEQ-------------LDA-YQ--------------------------DCT ------------------F-FTRKEILRLHARYHELAPHLVPMDY--TNDPDCKLPLALI VNM-----PELKENPFCSRIVESFSEDG--M---------GNLSFNEFVDMFSVLSEMAP ----------------RELKAIYAFKIY-DYNVDNFLCKEDLEKTLNK---LTKE----E --LTPEEVQLVCEK----AIEEADLDGD--HK---------LSFADFENM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ITRAPDFL---STFH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------I---------------- >T_nigroviridis_ENSTNIP00000011239 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-QT--IFTDEQ-------------LDA-YQ--------------------------DCT ------------------F-FTRKEILRLHGRYHELAPHLVPMDY--TNDPDCKLPLALI VNM-----PELKENPFRNRIVEAFSEDG--M---------GNLSFNEFVDMFSVLSETAP ----------------RELKAIYAFKIYADFNVDNFLCKEDLEKTLNK---LTKE----E --LTPEEVDLVCEK----TIEEADLDGD--NK---------LSFADFENM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ISRAPDFL---STFH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------I---------------- >G_gorilla_ENSGGOP00000010676 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------DCT ------------------F-FNKKDILKLHSRFYELAPNLVPMDY--RKSPIVHVPMSLI IQM-----PELRENPFKERIVAAFSEDG--E---------GNLTFNDFVDMFSVLCESAP ----------------RELKANYAFKIY-DFNTDNFICKEDLELTLAR---LTKS----E --LDEEEVVLVCDK----VIEEADLDGD--GK---------LGFADFEDM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------IAKAPDFL---STFH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------I---------------- >T_guttata_ENSTGUP00000000726 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-QT--IFTQEQ-------------LDA-YQ--------------------------DCT ------------------F-FTRKEILRLFHRYRDLAPQLVPLDY--SDRPAVTLPYELI GSM-----PELKDNPFRQRIAEVFSEHG--D---------GNMTLDDFLDMFSVLSEMAP ----------------RDLKAYYAFKIY-DFNNDDYICKSDLEKTVNK---LTRN----E --LTPEEVSLVCDK----VIYEADVDND--GK---------LSLADFQHM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------IVRAPDFL---STFH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------I---------------- >D_rerio_ENSDARP00000047008 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------H K-KA--IHHKES-------------RKC-YQ--------------------------DCT ------------------F-FTRKEILRLHGRYHELAPHLVPMDY--TNDPDVKVPLALI VNM-----PELKENPFRNRIVESFSEDG--Q---------GNLSFNDFVDMFSVLSEMAP ----------------RELKAIYAFKIY-DFNVDNYICKEDLEKTLNK---LTKE----E --LTPEEVNLVCEK----AIEEADLDGD--NK---------LSFADFENM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ISRAPDFL---STFH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------I---------------- >E_caballus_ENSECAP00000015921 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------S S-GS--RLSKEL-------------LAE-YQ--------------------------DLT ------------------F-LTKQEILLAHRRFCELLPQEH---RSVEESLQIRVSLEQI LSL-----PELKANPFKERICRVFSTSPTRD----------SLSFEDFLDLLSVFSDTAT ----------------PDIKSHYAFRIF-DFDDDGTLNRDDLSQLVNC---LTGEGEDTR --LSASEMKQLIDN----ILEESDIDRD--GT---------INLSEFQHV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ISRSPDFA---SSFK------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IV------------------L---------------- >B_taurus_ENSBTAP00000014575 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------Q--------------------------DCT ------------------F-FNKKDILKLHARFYELAPNLVPMDY--RKSPIVHVPMSLI IQM-----PELRENPFKERIVEAFSEDG--E---------GNLTFNDFVDMFSVLCESAP ----------------RELKASYAFKIY-DFNTDNFICKEDLQLTLAR---LTKS----E --LDEDEVVLVCDK----VIEEADLDGD--GK---------LGFADFEDM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------IAKAPDFL---RCGS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KG------------------L---------------- >G_aculeatus_ENSGACP00000022008 ------------------MPPPPQRVFALPRQQSLLLPAVINPFIQDTHLTKAAIIKCVL LGIILVPIRAVLMSLVLMVTWPVAVLITLNHPLK----GAVEPMTGWRRVMCRRVLAALG RTYYFCM-GFRVVVKGKQVDSTVAPILAVAPHSTFFDGIVCLVAGLPSTVSRVENLATPI FGRFVRCLQPVLVSRKDPDSRKNTIQEIESRAKSKGRWPQVLIFPEGTCTNRSCLITFKQ GAFVPGVPVQPVIMRYPNKLDTVTWTWQGFGSKMLLLLTLSQLYTTVEIEFLPTQIPTEE EKKSPPLFASRVRQTMAQTLAVPVTDHT-YEDCRLMISAGELTLPMEAGLVEFTKISRKL ------------------N-LKWDNVKKDLEGFAAIAGSCK----------GGRITIEEF AKF-----LKLPVNPALEELFALFDRNG--D---------GTIDFREYVIGVTILCRPAN ----------------TEDVLRMAFQLF-DIDKDEKITREEFSALLRS---ALG------ --VSNVNMAK--------LFKEIDADHS--GF---------ITFTEFHNF---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------AMVHPEYA---KLFSTYLELQRYQAIQEATPGDLE----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LT-------------------GSAEKQEESTSDKKDD >C_familiaris_ENSCAFP00000017815 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G S-GS--RLSKEL-------------LAE-YQ--------------------------ELT ------------------F-LTKQEILLAHRRFCELLPQEH---RSVEESLQIRVSLEQI LSL-----PELKANPFKERICRVFSTSPARD----------SLSFEDFLDLLSVFSDTAT ----------------PDIKSHYAFRIF-DFDDDGTLNREDLSQLVNC---LTGQGEDTR --LSASEMKQLIDN----ILEESDIDRD--GT---------INLSEFQHV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ISRSPDFA---SSFK------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IV------------------L---------------- >R_norvegicus_ENSRNOP00000013123 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------Q CLRY--QMQWED-------------LEE-YQ--------------------------ALT ------------------F-LTRNEILCIHDTFLKLCPPGK-------HYKEATLTMDQV SSL-----PALRVNPFRDRICRVFSHD-------------DVFSFEDVLGMASVFSEQAC ----------------PSLKIEYAFRIY-DFNENGFIDEEDLQKIVLR---LLKS---DD --VSEDLLQDVTHH----VLSESDLDND--NM---------LSFSEFEHA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------MAKSPDFM---NSFR------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IH------------------FWGC------------- >B_taurus_ENSBTAP00000028350 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G S-GS--RLSKEL-------------LAE-YQ--------------------------DLT ------------------F-LTKQEILLAHRRFCELLPQEH---RSVEESLQARVSLEQI LSL-----PELKANPFKERICKVFSTSPSRD----------SLSFEDFLDLLSVFSDTAT ----------------PDIKSHYAFRIF-DFDDDGTLNREDLSQLVNC---LTGESEDTR --LSASEMKQLIDN----ILEESDIDRD--GT---------INLSEFQHV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ISRSPDFA---SSFK------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IV------------------L---------------- >G_aculeatus_ENSGACP00000022250 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-QT--IFTAEQ-------------LDA-YQ--------------------------DCT ------------------Y-FTRKEILRLFDRYRDLAPQLVPLDY--TGQPDVKLPYELI GSM-----PELKDNPFRQRIAEVFSEDG--E---------GNMTLDDFLDMFSVLSEMAP ----------------RDLKAYYAFKIY-DFNNDDFICQSDLVKTLNK---LTRN----E --LTEDEVRMVCEK----VIDEADLDND--GR---------LSLEDFQHM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------IVRAPDFL---STFH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------I---------------- >M_domestica_ENSMODP00000019675 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------Q CLRH--PMSWEE-------------LEE-YQ--------------------------ALT ------------------F-LTRNEILCIHETFCKLCPRGK-------YYKEATLTMDQI SSL-----PALRVNPFRDRICRVFSHD-------------EVFSFEDILGMASVFSAQAC ----------------PSLKIEYAFRIY-DINENGFIDEDDLQNIIKR---LLNT---TD --VGDELLKNLIQH----VWYDADLDND--HM---------LSFAEFEHA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------MSKSPDFM---KSFR------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VH------------------F---------------- >M_musculus_ENSMUSP00000070901 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G S-GS--RLSKEL-------------LAE-YQ--------------------------DLT ------------------F-LTKQEILLAHRRFCELLPPEQ---RTVEESLHTRVSFEQI LSL-----PELKANPFKERICMVFSTSPTRD----------SLSFEDFLDLLSVFSDTAT ----------------PDIKSHYAFRIF-DFDDDGTLDREDLSQLVNC---LTGEGEDTR --LSASEMKQLIDN----ILEESDIDRD--GT---------INLSEFQHV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ISRSPDFA---SSFK------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IV------------------L---------------- >R_norvegicus_ENSRNOP00000019578 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-QT--VFSHEQ-------------LEE-YQ--------------------------DCT ------------------F-FTRKEIMRLFYRYQDLAPQLVPLDY--TTSPEVKVPYELI GSM-----PELKDNPFRQRIAQVFSQDG--D---------GHMTLENFLDMFSVMSEMAP ----------------RDLKAYYAFKIY-DFNNDNYICTWDLEQTVTR---LTRG----E --LSVEEVTLVCEK----VLDEADSDHD--GR---------LSLEDFQNM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ILRAPDFL---STFH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------I---------------- >G_gallus_ENSGALP00000034335 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-QT--IFTPEQ-------------LDA-YQ--------------------------DCT ------------------F-FTRKEILRLFYKYRDLAPQLVPLDY--TDKPNVTLPYELI GSM-----PELKDNPFRQRIAEVFSESG--D---------GNMTLDDFLDMFSVLSEMAP ----------------RDLKAYYAFKIY-DFNNDDYICKSDLEKTVNK---LTRN----E --LTPEEVSLACEK----VIYEADLDND--GK---------LSLEDFQHM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------IIRAPDFL---STFH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------I---------------- >O_latipes_ENSORLP00000014731 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------T T-AS--QLDKGM-------------LSE-YQ--------------------------ELT ------------------F-LTKQEILLAYKRFSELLPKEE------TNGISYRIPMNAI LEL-----PELKTNPFNERICKVFSTSDSHD---------GSLNFDDFLDLLSAFSDSAT ----------------LEIKSHYAFRIF-DFDDDGTLGRQDLEKLVNC---LTGGTGDTS --LTPDEMKQLIDN----ILEESDIDKD--GT---------VNLSEFQHV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ISRSPDFV---SSFK------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IV------------------L---------------- >P_pygmaeus_ENSPPYP00000014043 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------Q CLRY--QMHWED-------------LEE-YQ--------------------------ALT ------------------F-LTRNEILCIHDTFLKLCPPGK-------YYKEATLTMDQV SSL-----PALRVNPFRDRICRVFSHK-------------GVFSFEDVLGMASVFSEQAC ----------------PSLKIEYAFRIY-DFNENGFIDEEDLQKIILR---LLNS---DD --MSEDMLMDLTNH----VLSESDLDND--NM---------LSFSEFEHA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------MAKSPDFM---NSFR------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IH------------------FWGC------------- >H_sapiens_ENSP00000269878 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-QT--VFTHEQ-------------LEA-YQ--------------------------DCT ------------------F-FTRKEIMRLFYRYQDLAPQLVPLDY--TTCPDVKVPYELI GSM-----PELKDNPFRQRIAQVFSEDG--D---------GHMTLDNFLDMFSVMSEMAP ----------------RDLKAYYAFKIY-DFNNDDYICAWDLEQTVTK---LTRG----G --LSAEEVSLVCEK----VLDEADGDHD--GR---------LSLEDFQNM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ILRAPDFL---STFH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------I---------------- >C_intestinalis_ENSCINP00000018684 ------------------------------------------------------------ ----------MSLAILTMVTERENVWETEKIGIA----IMCAGVVMVVFNRIHKYLPFLK CWTKADADG--------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------AE IERQTLRYMPES-------------IER-LM--------------------------ALT ------------------N-FDRRELKTLYRNFKNECPNG-------------VVNEETF KSIYCQFFPNGDADMYAHYVFRAFDHSE--E---------GHVNFEEFAIGLSSLLRGS- ----------------LIDRLHWTFRLY-DINHDGYITREEMLSIIKSVYQLLGSHVTPS --LSDDNYMEHTDR----IFNKLDLNGD--GL---------VTMEEFCET---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------CTKDESIV---RSMS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IF-------------------------------DHAL >R_norvegicus_ENSRNOP00000047025 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G S-GS--RLSKEL-------------LAE-YQ--------------------------DLT ------------------F-LTKQEILLAHRRFCELLPPEH---RTVEESLHTRVSFEQI LSL-----PELKANPFKERICMVFSTSPTRD----------SLSFEDFLDLLSVFSDTAT ----------------PDIKSHYAFRIF-DFDDDGTLDREDLSRLVNC---LTGEGEDTR --LSASEMKQLIDN----ILEESDIDRD--GT---------INLSEFQHV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ISRSPDFA---SSFK------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IV------------------L---------------- >M_domestica_ENSMODP00000018631 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-QT--VFTPEQ-------------LDA-YQ--------------------------DCT ------------------F-FTRKEILKLFYRFQDLAPQLVPFDY--TGKPDVKLPYEVI CGM-----PELKDNPFRERIAQVFSQDG--D---------GNMTLDDFLDMFSVMSEMAP ----------------RDLKAYYAFKIY-DFNNDDYICPLDLEKTVTK---LTRG----E --LTPEEVGLVCEK----VINEADVDND--GK---------LSLDDFQNM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ILHAPDFL---STFH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------I---------------- >X_tropicalis_ENSXETP00000028400 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N S-SS--HLSKQL-------------INE-YQ--------------------------ELT ------------------Y-LTKQEIILAYKRFSEVAQKDN-----RSNIESLRIPKERF LNL-----PELKANPFNDRICTVFSTSEQED---------GSMSFEDFLDMLSAFSESAT ----------------LEVKSHYAFRIF-DFDGDGALNESDLEHLVNK---LTGDKDDTK --LSNSEMRQLIAN----ILEESDIDKD--GT---------INHSEFQHV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ISRSPDFI---SVFN------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------FM------------------I---------------- >C_familiaris_ENSCAFP00000006660 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------Q CLRH--QMHCED-------------LEE-YQ--------------------------ALT ------------------F-LTRNEILCIHDTFLKLCPPGK-------YYKEATLTTDQV SSL-----PALRVNPFRDRICKVFSHN-------------NVFSFEDVLSMASVFSEQAC ----------------PSLKIEYAFRIY-DFNENGFIDEEDLQRIVLR---LLNS---DD --VSEDLLTDLTNH----VLNESDLDND--NM---------LSFSEFEHA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------MAKSPDFM---NSFR------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IH------------------FWGF------------- >P_troglodytes_ENSPTRP00000018164 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-QT--VFTHEQ-------------LEA-YQ--------------------------DCT ------------------F-FTRKEIMRLFYRYQDLAPQLVPLDY--TTCPDVKVPYELI GSM-----PELKDNPFRQRIAQVFSEDG--D---------GHMTLDNFLDMFSVMSEMAP ----------------RDLKAYYAFKIY-DFNNDDYICAWDLEQTVTK---LTRG----E --LSAEEVSLVCEK----VLDEADGDHD--GR---------LSLEDFQNM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ILRAPDFL---STFH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------I---------------- >B_taurus_ENSBTAP00000021537 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-QT--VFTHEQ-------------LEA-YQ--------------------------DCT ------------------F-FTRKEIMRLFYRYQDLAPQLVPLDY--TSCPDVKVPYELI GSM-----PELKDNPFRQRIAQVFSEDG--D---------GHMTLDNFLDMFSVMSEMAP ----------------RDLKAYYAFKIY-DFNNDDYICAWDLEQTVTK---LTRG----E --LSTEEVSLICEK----VLDEADGDHD--GR---------LSLEDFQNM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ILRAPDFLR--ENQH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SR------------------E---------------- >E_caballus_ENSECAP00000017545 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------Q CLRY--QMHWED-------------LEE-YQ--------------------------ALT ------------------F-LTRNEILCIHDTFLKLCPPGK-------YYKEATLTMDQV SSL-----PALRVNPFRDRICRVFAHN-------------GVFSFEDVLGMASVFSEQAC ----------------PSLKIEYAFRIY-DFNENGFIDEEDLQEIILR---LLNS---DD --MSEDLLTDLTSH----VLSESDLDND--NM---------LSFSEFEHA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------MAKSPDFM---NSFR------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IH------------------FWGC------------- >C_familiaris_ENSCAFP00000023200 ------------------------------------------------------------ ------------------------------------------------------------ ------M-G--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N K-QT--VFTHEQ-------------LEA-YQ--------------------------DCT ------------------F-FTRKEIMRLFYRYQDLAPQLVPLDY--TSCPDVKVPYELI SSM-----PELKDNPFRQRIAQVFSEDG--D---------GHMTLDNFLDMFSVMSEMAP ----------------RDLKAYYAFKIY-DFNNDGYICAWDLEQTVTK---LTRG----E --LSAEEVSLVCEK----VLDEADGDHD--GR---------LSLEDFQNM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ILRAPDFL---STFH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IR------------------I----------------