>H_sapiens_ENSP00000339151 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------W-----------SPS-------------LTTQT--CGAWEMKERLGTGG FGNVIRWHNQ--ETGEQIAIKQC-----RQ-ELSP-RNR-----ERWCLEIQIM-RRLTH PNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--YLNQFENCCGL REGAILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-EQRLIHKIIDLGYAK ELDQG----SLCT-SFVGTLQYL-----------------------APELLE-------- QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHS---KVR----QKS EVDIV--VSEDLNGTVKFSSSLPYPNNL----NSVLAERLEKWLQLMLMWHPRQRG---- ---------------TDPTYGPN----GCFKALDDILNLKLV--------HILNMVTGTI HTYPVTEDES--LQSLKARIQQDTGIPE--EDQ-------ELLQEAGLA---LIPDKPAT QCISDGKLNEG-HTLDM----------DLVFLFD---NSKITYETQISPR---------- PQPESVSCILQE------------------------------------------------ ------------PK-RNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQ-------------- GQRAAMMNLL-------------RNNSCLSKMKNSMASMSQ---QLKAKLDF--FKTSIQ IDLEKYSEQTEFGITSDKLLLAWREMEQAV----------------EL-CGR----ENEV KLLVERMM--A--------LQTDIVDLQRSP----MGR---KQG-GTLDDLEEQARE-LY ------------RRLREK---PRDQRTEGDSQEMVRLLLQAIQSFEKK------------ ------------------------------------------------------------ ---VRV--IYTQLSKTVVCKQKALELL------------PKVE---EVVSLMNE------ ----------------------DEKTVVRL-QEKRQKELWNLLK--------IAC---SK VRGPVSGSP--DS----------------------------------------------- ------------------------------------------------------------ ----MNASR----LSQPGQL-MSQPSTASNSLP-----EPA--KKSEELVAEAHNLCTLL ENAIQDTVRE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QDQ----SFTAL-DWSWLQTEEEE-HSCLEQA-S------ >M_mulatta_ENSMMUP00000010949 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------W-----------SPS-------------LTTQT--CGAWEMKERLGTGG FGNVIRWHNQ--ETGEQIAIKQC-----RQ-ELSP-RNR-----ERWCLEIQIM-RRLTH PNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--YLNQFENCCGL REGAILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-EQRLIHKIIDLGYAK ELDQG----SLCT-SFVGTLQYL-----------------------APELLE-------- QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHS---KVR----QKS EVDIV--VSEDLNGTVKFSSSLPYPNNL----NSVLAERLEKWLQLMLMWHPRQRG---- ---------------TDPKYGPN----GCFKALDDILNLKLV--------HILNMVTGTI HTYPVTEDES--LQSLKARIQQDTGIPE--EDQ-------ELLQEAGLA---LIPDKPAT QCISDGKLNEG-RTLDM----------DLVFLFD---NSKITYETQISPR---------- PQPESVSCILQE------------------------------------------------ ------------PK-RNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQ-------------- GQRAAMMNLL-------------RNNSCLSKMKNSMASMSQ---QLKAKLDF--FKTSIQ IDLEKYSEQTEFGITSDKLLLAWREMEQAV----------------EL-CGR----ENEV KLLVERMM--A--------LQTDIVDLQRSP----MGR---KQG-GTLDDLEEQARE-LY ------------RRLREK---PRDQRTEGDSQEMVRLLLQAIQSFEKK------------ ------------------------------------------------------------ ---VRV--IYTQLSKTVVCKQKALELL------------PKVE---EVVSLMNE------ ----------------------DEKTVVRL-QEKRQKELWNLLK--------IAC---SK VRGPVSGSP--DS----------------------------------------------- ------------------------------------------------------------ ----MNASR----LSQPGQL-MSQPSTASNSLP-----EPA--KKSEELVAEAHNLCTLL ENAIQDTVRE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QDQ----SFTAL-DWSWLQTEEEE-HSCLEQA-S------ >P_troglodytes_ENSPTRP00000034602 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------W-----------SPS-------------LTTQT--CGAWEMKERLGTGG FGNVIRWHNQ--ETGEQIAIKQC-----RQ-ELSP-RNR-----ERWCLEIQIM-RRLTH PNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--YLNQFENCCGL REGAILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-EQRLIHKIIDLGYAK ELDQG----SLCT-SFVGTLQYL-----------------------APELLE-------- QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHS---KVR----QKS EVDIV--VSEDLNGTVKFSSSLPYPNNL----NSVLAERLEKWLQLMLMWHPRQRG---- ---------------TDPTYGPN----GCFKALDDILNLKLV--------HILNMVTGTI HTYPVTEDES--LQSLKARIQQDTGIPE--EDQ-------ELLQEAGLA---LIPDKPAT QCISDGKLNEG-HTLDM----------DLVFLFD---NSKITYETQISPR---------- PQPESVSCILQE------------------------------------------------ ------------PK-RNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQ-------------- GQRAAMMNLL-------------RNNSCLSKMKNSMASMSQ---QLKAKLDF--FKTSIQ IDLEKYSEQTEFGITSDKLLLAWREMEQAV----------------EL-CGR----ENEV KLLVERMM--A--------LQTDIV--------------------------EEQARE-LY ------------RRLREK---PRDQRTEGDSQEMVRLLLQAIQSFEKK------------ ------------------------------------------------------------ ---VRV--IYTQLSKTVICKQKALELL------------PKVE---EVVSLMNE------ ----------------------DEKTVVRL-QEKRQKELWNLLK--------IAC---SK VRGPVSGSP--DS----------------------------------------------- ------------------------------------------------------------ ----MNASR----LSQPGQL-MSQPSTASNSLP-----EPA--KKSEELVAEAHNLCTLL ENAIQDTVRE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QDQ----SFTAL-DWSWLQMEEEE-HSCLEQA-S------ >C_familiaris_ENSCAFP00000008270 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------W-----------SPS-------------LPTQT--CGAWEMKERLGTGG FGNVIRWHNQ--ETGEQIAIKQC-----RQ-ELSP-RNR-----ERWCLEIQIM-RRLNH PNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--YLNQFENCCGL REGAILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-EQRLIHKIIDLGYAK ELDQG----SLCT-SFVGTLQYL-----------------------APELLE-------- QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHS---KVR----QKS EMDIV--VSEDLNGAVKFSSSLPYPNNL----NSILAQRLEKWLQLMLMWHPRQRG---- ---------------TDPVYGPN----GCFKALDDILNLKLV--------HILNMVTGII HTYPVTEDES--LQNLKARIQHDTGIPE--KDQ-------ELLQEAGLA---LIPDKPAA QCISDGKLNEG-RTLDM----------DLVFLFD---NSKIAYETQISPR---------- PQPESVSCILQE------------------------------------------------ ------------PK-RNLSFFQLRKVWGQVWHSIQTLKEDCNRLQQ-------------- GQRAAMMNLL-------------RNNSCLSKMKNSMASMSQ---QLKAKLDF--FKTSIQ IDLEKYSEQTEFGITSDKLLLAWREMEQAV----------------EL-CGR----ENEV KHLVERMM--A--------LQTDIVDLQRSP----MGR---KQG-GTLDDLEEQARE-LY ------------RRLREK---PRDQRTDGDSQEMVRLLLQAIQGFEKK------------ ------------------------------------------------------------ ---VRV--IYTQLSKTVVCKQKALELL------------PKVE---EVVSLMNE------ ----------------------DEKTVVRL-QEKRQKELWNLLK--------IAC---SK VRGPVSGSP--DS----------------------------------------------- ------------------------------------------------------------ ----MNASR----LSHSGQL-LAQPSPAPSSLP-----EAI--KKSEELVAEAHTLCTQL ENAMQDTIKE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QDQ----SLRSL-DWSWLQTEEEQ-NS-LEQA-S------ >M_musculus_ENSMUSP00000033939 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------W-----------SPS-------------LPTQT--CGAWEMKERLGTGG FGNVIRWHNQ--ATGEQIAIKQC-----RQ-ELSP-KNR-----DRWCLEIQIM-RRLNH PNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRR--YLNQFENCCGL REGAVLTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-EKRLIHKIIDLGYAK ELDQG----SLCT-SFVGTLQYL-----------------------APELLE-------- QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHS---KVR----QKS EVDIV--VSEDLNGAVKFSSSLPFPNNL----NSVLAERLEKWLQLMLMWHPRQRG---- ---------------TDPQYGPN----GCFRALDDILNLKLV--------HVLNMVTGTV HTYPVTEDES--LQSLKTRIQEDTGILE--TDQ-------ELLQEAGLV---LLPDKPAT QCISDSKTNEG-LTLDM----------DLVFLFD---NSKINYETQITPR---------- PQPESVSCILQE------------------------------------------------ ------------PK-RNLSFFQLRKVWGQVWHSIQTLKEDCNRLQQ-------------- GQRAAMMSLL-------------RNNSCLSKMKNAMASTAQ---QLKAKLDF--FKTSIQ IDLEKYKEQTEFGITSDKLLLAWREMEQAV----------------EQ-CGR----ENDV KHLVERMM--A--------LQTDIVDLQRSP----MGR---KQG-GTLDDLEEQARE-LY ------------RRLREK---PRDQRTEGDSQEMVRLLLQAIQSFEKK------------ ------------------------------------------------------------ ---VRV--IYTQLSKTVVCKQKALELL------------PKVE---EVVSLMNE------ ----------------------DERTVVRL-QEKRQKELWNLLK--------IAC---SK VRGPVSGSP--DS----------------------------------------------- ------------------------------------------------------------ ----MNVSR----LSHPGQL-MSQPSSACDSLP-----ESD--KKSEELVAEAHALCSRL ESALQDTVKE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QDR----SFTTL-DWSWLQMEDEE-RCSLEQACD------ >R_norvegicus_ENSRNOP00000025851 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------W-----------SPS-------------LPTQT--CGAWEMKERLGTGG FGNVIRWHNQ--VTGEQIAIKQC-----RQ-ELSP-KNR-----DRWCLEIQIM-RRLNH PNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRR--YLNQFENCCGL REGAILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-EKRLIHKIIDLGYAK ELDQG----SLCT-SFVGTLQYL-----------------------APELLE-------- QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHS---KVR----QKS EVDIV--VSEDLNGTVKFSSSLPFPNNL----NSVLAERLEKWLQLMLTWQPRQRG---- ---------------VDPQYGPN----GCFRALDDILNLKLV--------HILNMVTGTI HTYPVMEDES--LQSLKTRIREDTGILE--TDQ-------ELLQEAGLV---LLPDKPAT QCISDSKTNEG-LTLDM----------DLVFLFD---NSKMSYETQITPR---------- PQPESVSCVLQE------------------------------------------------ ------------PK-RNLSFFQMRKVWGQVWHSIQTLKEDCNRLQQ-------------- GQRAAMMNLL-------------RNNSCLSKMKNAMASTAQ---QLKAKLDF--FKTSIQ IDLEKYREQTEFGITSDKLLLAWREMEQAV----------------EQ-CGR----ENDV KVLVERMM--A--------LQTDIVDLQRSP----MGR---KQG-GTLDDLEEQARE-LY ------------RRLREK---PRDQRTEGDSQDMVRLLLQAIQSFEKK------------ ------------------------------------------------------------ ---VRV--IYSQLSKTVVCKQKALELL------------PKVE---EVVRLMNE------ ----------------------DEKTVVRL-QEKRQKELWNLLK--------IAC---SK VRGPVSGSP--DS----------------------------------------------- ------------------------------------------------------------ ----MNVSR----LSHPGHL-MSQPSSACDSLP-----DSD--KKSEELVAEAHALCSRL ESALQDTVKQ-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QDR----SFTTL-DWSWLQMEDEE-RCGLEQACD------ >B_taurus_ENSBTAP00000049055 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------W-----------SPS-------------LPTQT--CGAWEMKERLGTGG FGNVIRWHNQ--ETGEQIAIKQC-----RQ-ELSP-RNR-----ERWCLEIQIM-RRLNH PNVVAAR----DVP-----EGMQSL-APN-DLPLLAMEYCQGGDLRK--YLNQFENCCGL REGAILTLLSDI--ASALRYLHEN-NHIVNHPKMQESDNLSEVG-EFKLIHKIIDLGYAK ELDQG----SLCT-SFVGTLQYL-----------------------APELLE-------- QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHS---KVR----QKS EMDIV--VSEDLNGAVKFSSSLPHPNNL----NSVLAQRLEKWLQLMLMWHPRQRG---- ---------------TDPVYGPN----GCFKALDDILNLKLL--------HVLNMVTGTL HTYPVTEDES--LQSLKARIRQDTGILE--EDQ-------ELLQEAGLA---LIPDKPAA QCLSDGKLNEG-RTLDM----------DLVFLFD---NSRVTYESQVSPQ---------- PQPESVSCILQE------------------------------------------------ ------------PK-RNLPFFQLRKVWGQVWHSIQALKEDCSRLQQ-------------- GQRAAMMNLL-------------RNNSCLSKMKNSMASMSQ---QLKAKLDF--FKTSIQ IDLEKYREQTEFGITSDKLLLAWREMEQAV----------------EL-CGR----ENEV KHLVERMM--A--------LQTDIVDLQRSP----MGR---KQG-GTLDDLEEQARE-LY ------------RRLREK---PRDQRTDGDSQEMVRLLLQAIQGFEKK------------ ------------------------------------------------------------ ---VRV--IYTQLSKTVVCKQKALELL------------PKVE---EVVSLMSE------ ----------------------DEKMVVRL-QEKRQKELWNLLK--------IAC---SK VRGPVSGSP--DS----------------------------------------------- ------------------------------------------------------------ ----MNASR----LSHPCQL-MSQPCTAPDSLP-----EAA--EKSEDLVAEAHTLCTQL ENALQDTMKE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QDQ----SLRSL-DWSWLQSEEEE-QQSLERA-S------ >P_pygmaeus_ENSPPYP00000020804 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------SVFLL-PRLTH PNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--YLNQFENCCGL REGAILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-EQRLIHKIIDLGYAK ELDQG----SLCT-SFVGTLQYL-----------------------APELLE-------- QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHS---KVR----QKS EVDIV--VSEDLNGTVKFSSSLPYPNNL----NSVLAERLEKWLQLMLMWHPRQRG---- ---------------TDPTYGPN----GCFKALDDILNLKLV--------HILNMVTGTI HTYPVTEDES--LQSLKARIQQDTGIPE--EDQ-------ELLQEAGLA---LIPDKPAT QCVSDGKLNEG-RTLDM----------DLVFLFD---NSKITYETQISPR---------- PQPESVSCILQE------------------------------------------------ ------------PK-RNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQ-------------- GQRAAMMNLL-------------RNNSCLSKMKNSMASMSQ---QLKAKLDF--FKTSIQ IDLEKYSEQTEFGITSDKLLLAWREMEQAV----------------EL-CGR----ENEV KLLVERMM--A--------LQTDIVDLQRSP----MGR---KQG-GTLDDLEEQARE-LY ------------RRLREK---PRDQRTEGDSQEMVRLLLQAIQSFEKK------------ ------------------------------------------------------------ ---VRV--IYTQLSKTVVCKQKALELL------------PKVE---ELVSLMNE------ ----------------------DEKTVVRL-QEKRQKELWNLLK--------IAC---SK VRGPVSGSP--DS----------------------------------------------- ------------------------------------------------------------ ----MNASR----LSQPGQL-MSQPSTASNSLP-----EPA--KKSEELVAEAHNLCTLL ENAIQDTVRE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QHQ----SFTAL-DWSWLQTEEEE-HSCLEQA-S------ >O_anatinus_ENSOANP00000001111 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------W-----------PPS-------------LQTQT--CGVWEMKERLGTGG FGNVIRWHNK--ETGEQIAIKQC-----RQ-ELST-RNR-----ERWCLEIQIM-RRLNH PNVVAAR----EVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--FLNQFENCCGL REGAILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-QQRLIHKIIDLGYAK ELDQS----SLCT-SFVGTLQYL-----------------------APELLE-------- QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHS---TVR----QKS ELDIV--VSEDLTGEVKFSSRLPYPNNL----NRVLALRLEKWLQLMLMWQPRQRG---- ---------------TDHIYGPN----GCFKALDDILNLKLI--------HVLNMVTGTM HTYPVTEEES--LQSMKARIQADTKIPE--EDQ-------ELLQEAGLA---LFSDKPDT QGITDGKLNDG-RIWDM----------DLLFLFD---NSKVTYETQISPR---------- SHPESVSCILQE------------------------------------------------ ------------PK-KNLAFFQLRKVWGQVWHTIRTLKEDCNRLQQ-------------- GQRAAMMNLL-------------RYNSSLSKMKNSMASMSQ---QLKAKLDF--FKTSVQ IDLEKYSEQTEFGITSDKLLLAWREMEQAV----------------EL-CGR----EAEV EQLVGRMM--A--------LQTDIVDLQRSP----MGR---KQG-GNLDDLEEQARE-LY ------------RKLREK---PRDQRTSGDSQEMVRLLLQAIQSFEKK------------ ------------------------------------------------------------ ---VRV--IYNQLSKTVVCKQKALELF------------PKVE---EVMSLMNE------ ----------------------DEKTVVQL-QEKRQKELWNLLK--------IAC---SK VRGPVSGSP--DS----------------------------------------------- ------------------------------------------------------------ ----MNTSR----LSNSNQL-LSQPPAVPCSLP-----EPI--RKSEDLVVEAQNLCTQL ENAMQDTMKE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QDR----SFMAL-DWSWLQIDDEE-RNSLEQTQI------ >E_caballus_ENSECAP00000003662 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------W-----------SPS-------------LPTQT--CGAWEMKERLGTGG FGNVIRWHNQD-QNGSSVASVQC-----RQADISI-RSF-----QPWTFDSRAL-VLLNH PNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--YLNQFENCCGL REGAILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-EQRLIHKIIDLGYAK ELDQG----SLCT-SFVGTLQYL-----------------------APELLE-------- QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHS---KVR----QKS EVDIV--VSEDLNGTVKFSSSLPYPNNL----NSRMGSRLCVGLECM---NCGTRA---- ---------------AFPKLGPC----FLWLGINIWVVLQLV--------HILNMVTGTI HTYPVTEDES--LQSLKARIQQDTGIPE--EDQ-------ELLQEAGLA---LIPDKPAT QCISDGKLNEG-RTLDM----------DLVFLFD---NSKIAYETQISPR---------- PQPESVSCILQE------------------------------------------------ ------------PK-RSLSFFQLRKVWGQVWHSIQTLKEDCSRLQQ-------------- GQRAAMMNLL-------------RNNSCLSKMKNSMASMSQ---QLKAKLDF--FKTSIQ IDLEKYSEQTEFGITSDKLLLAWREMEQAV----------------EL-CGR----ENEV RHLVERMM--A--------LQTDIVDLQRSP----MGR---KQG-GTLDDLEEQARE-LY ------------RRLREK---PRDQRTDGDSQEMVRLLLQAIQGFEKK------------ ------------------------------------------------------------ ---VRV--IYTQLSKTVVCKQKALELL------------PKVE---EVVSLMNE------ ----------------------DEKTVVRL-QEKRQKELWNLLK--------IAC---SK VRGPVSGSP--DS----------------------------------------------- ------------------------------------------------------------ ----MNASR----LSHSGQL-VSQPSTTPDSLP-----ESA--KKSEELVAEAHSLCTQL ENAIQDTMKD-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QDQ----SLRSL-DWSWLQTEDNE-QHSLEQA-S------ >M_domestica_ENSMODP00000012792 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------Q--ETGEQIAIKQC-----RQ-ELSL-RNR-----ERWCLEIQIM-RRLNH PNVVAAR----DVP-----EGMQKL-APN-DLPLLAMEYCQGGDLRK--YLNQFENCCGL REEAILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-EKRLIHKIIDLGYAK ELDQG----SLCT-SFVGTLQYL-----------------------APELLE-------- QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHS---KVR----QKS ELDIV--VSEDLSGGVKFSSCLPYPNNL----NSILAQRLEKWLQLMLMWQARQRG---- ---------------TDPTYGPN----GCFKALDDILNLKLV--------HILNMVTGTV HTYPIMEKES--LQSLKARIQADTGIPE--EDQ-------ELLQEAGLA---LFSDKPAT QCIVDSKLNDD-RILDM----------DLIFLFD---NRKITYETQISPR---------- PPPESVSCILQE------------------------------------------------ ------------PK-RNLPFFQLRKVWGQVWHTIRTLKEDCSQLQQ-------------- GQRAAMMNLL-------------RNNSSLSKMKNLMASMSQ---QLKAKLDF--FKTSIQ IDLEKYSEQTEFGITSDKLLLAWREMEQAV----------------EL-CGR----ESDV KLLVEQMM--A--------LQTDIVDLQRSP----MSR---KQG-GTLDDLEEQARE-LY ------------RRLREK---PRDQRTDGDSQEMVRLLLQAIQSFEKK------------ ------------------------------------------------------------ ---VRA--IYMQLSKTMVCKQKALELL------------PQVE---EVVSLMNE------ ----------------------DEKTVVQL-QEKRQKELWNLLK--------IAC---SK VRGPVSGSP--DS----------------------------------------------- ------------------------------------------------------------ ----MNASR----LSNPSQL-LSQPPTAPYSLP-----DSI--KKSEELVTETQSLCTQL QSMMEDAMKK-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QDQ----SFMTL-DWSWLHSEDGE-DEGVEQTQI------ >G_gallus_ENSGALP00000005924 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------R-----------PPA-------------LQAQT--CGPWEMKERLGTGG FGNVIRWHNK--ETGEQVAIKQC-----RQ-ELSP-RNR-----DRWALEIQIM-KRLNH PNVVAAR----DVP-----EGMQKL-APN-DLPLLAMEYCQGGDLRK--YLNQLENCCGL REEAILILLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-EQRLIHKIIDLGYAK ELDQG----SLCT-SFVGTLQYL-----------------------APELLE-------- QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHT---KVR----QKS ELDIV--VSEDLSGEVKFSSSLPCPNNL----NSVLAGKLEKWLQLMLMWHPRQRG---- ---------------TDPVYGPN----GCFKALDDILNLKLL--------HVLNMVTGTV HTYPVTEEET--LQTVKARIQSDTGIPE--QDQ-------ELLQEAGLA---LFTQKHT- ---ADSKVNDA-VVADT----------DLLFLFD---NQKVAYEAQVALR---------- PHPESVDYILQD------------------------------------------------ ------------PK-KNLHFFQLRKVWGQIWHTIRMLKEDCNRLQQ-------------- GQRAAMMNLL-------------RYNSTLSKMKNSMASLSQ---QLKAKLDF--FKTSIQ IDLEKYKEQIEFGITSEKLLFAWKEMEQAV----------------EL-CGR----EDDV DQLVKRMM--A--------LQTDIVDLQRSP----LGR---KQG-GTLEDLEEQARE-LY ------------RRLREK---PRDQRTSGDSQEIVRLLLQAIQTFEKK------------ ------------------------------------------------------------ ---VRV--IYAQLSKTVVCKQKALELF------------PRVE---KVMNLMNE------ ----------------------DEETVVRL-QEKRQKELWNLLK--------IAC---SK VRGPVSGSP--ES----------------------------------------------- ------------------------------------------------------------ ----MNMSR----LNSPGQL-LLQVPSGTYALS-----ESV--RKSEELLLESQKLCSQL ENVMHDTMKD-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QEQ----SFMAL-DWSWLQLHVEE-RSSPEQTHM------ >G_gorilla_ENSGGOP00000006628 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------W-----------SPS-------------LTTQT--CGAWEMKERLGTGG FGNVIRWHNQ--ETGEQIAIKQC-----RQ-ELSP-RNR-----ERWCLEIQIM-RRLTH PNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--YLNQFENCCGL REGAILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-EQRLIHKIIDLGYAK ELDQG----SLCT-SFVGTLQYL-----------------------APELLE-------- QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHS---KVR----QKS EVDIV--VSEDLNGTVKFSSSLPYPNNL----NSVLAERLEKWLQLMLMWHPRQRG---- ---------------TDPTYGPN----GCFKALDDILNLKLV--------HILNMVTGTI HTYPVTEDES--LQSLXXXXXXXXXXXX--XXX-------XXXXXXXXX---XXXXXXXX XXXXXXXLNEG-RTLDM----------DLVFLFD---NSKITYETQISPR---------- PQPESVSCIXXX------------------------------------------------ ------------XX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-------------- XXXXXXMNLL-------------RNNSCLSKMKNSMASMSQ---QLKAKLDF--FKTSIQ IDLEKYSEQTEFGITSDKLLLAWREMEQAV----------------EL-CGR----ENEV KLLVERMM--A--------LQTDIVDLQRSP----MGR---KQG-GTLDDLEEQARE-LY ------------RRLREK---PRDQRTEGDSQEMVRLLLQAIQSFEKK------------ ------------------------------------------------------------ ---VRV--IYTQLSKTVVCKQKALELL------------PKVE---EVVSLMNE------ ----------------------DEKTVVRL-QEKRQKELWNLLK--------IAC---SK VRGPVSGSP--DS----------------------------------------------- ------------------------------------------------------------ ----MNASR----LSQPGQL-MSQPSTASNSLP-----EPA--KKXXXXXXXXXXXXXXX XXXXXXXXXX-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------XXX----XXXAL-DWSWLQTEEEE-HSCLEQA-S------ >A_carolinensis_ENSACAP00000012680 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------A------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------P-----------PPL-------------QPLAS--CGAWEMRERLGTGG FGNVIRWQHR--ETGEQIAIKQC-----RQ-ELSL-RNR-----ERWCLEIQIM-KRLNH PNVVAAR----DVP-----EGMQSL-ALN-DLPLLAMEYCQGGDLRR--HLNQLENCCGV RERAILILLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-EERLIHKIIDLGYAK ELDQG----SLCT-SFVGTLQYL-----------------------APELLE-------- QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHT---KVR----QKS ELDIV--VYEDLNGEVKFSSKLPHPNNL----NSVLADRLEKWLQLMLKWHPRQRG---- ---------------TDPTYGTN----GCFKALDDILNLKLV--------HILNMVTGIV HVYPLAEEET--LQSIKAKVEAETGIPE--QDQ-------ELLQEGGLA---LFPEKPDI QYTADIKLNDA-TAADI----------GLLFLFD---NRKVTYESQISPR---------- PHPDSINCILQD------------------------------------------------ ------------PK-KTLAFFQLRKVWGQVWHSIRRLNEDFNQLQN-------------- GQRAAMRNLL-------------RHNSTLSKMKNNMASLSQ---QLKAKLDF--FKASIQ IDLEKYNEQIQFGITSEKLLLAWKEMEQAI----------------EL-RGR----EEDV DQLVKKTM--A--------LQTDIVDLQRIP----QGR---KQG-SSLDDLEEQARD-LY ------------RKLREK---PRDQRTSGDSQEVVRLLLQAIQTFEKK------------ ------------------------------------------------------------ ---VRL--LYVQLSNTVVCKQKALELF------------PKVD---EVMSLMKE------ ----------------------DEKTVVGL-QEKRQKELWNLLK--------IAC---NK VRGPVSGSP--DS----------------------------------------------- ------------------------------------------------------------ ----MNPSR----LSSPGQL-PLQVTAPQSNAG-----DAG--IKSEELLTESQTLCSQL ENVMLDTMKD-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QEH----SFMAL-DWSWLKLRAEE-KENLEQT-Q------ >O_cuniculus_ENSOCUP00000006175 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ETGEQIAIKQC-----RQ-ELSP-RNR-----ERWCLEIQIM-RRLNH PNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--XXXXXXXXXXX XXXXXXXXXXXX--XSALRYLHEN-RII--HRDLKPENIVLQQG-EQRXXXXXXXXXXXX XXXXX----XXXX-XXXXXXXXX-----------------------APELLE-------- QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHS---KVR----QKS EMDIV--VSEDLNGAVKFSSSLPYPNNL----NSILAQRLEKWLQLMLMWHPRQRG---- ---------------TDPTYGPN----GCFKALDDILNLKLV--------HILNMVTGTV HSYPVSEDES--LQSLKARIQSDTGISE--QDQ-------ELLQEAGLA---LIPDKPAT QCISDGKLNEG-RTLDM----------DLVFLFD---NSKVAYETQISPR---------- PQPESVSCILQE------------------------------------------------ ------------PK-RNLPFFQLRKVWGQVWHSIQTLKEDCNRLQQ-------------- GQRAAMMNLL-------------RNNSCLSKMKNSMASISQ---QLKAKLDF--FKTSIQ IDLEKYSEQTEFGITSDKLLLAWREMEQAV----------------EL-CGR----EDEV KHLVERMM--A--------LQTDIVDLQRSP----MGR---KQG-GTLDDLEEQARE-LY ------------RRLREK---PRDQRTDGDSQEMVRLLLQAIQGFEKK------------ ------------------------------------------------------------ ---VRV--IYTQLSKTVVCKQKALELL------------PKVE---EVVSLMNE------ ----------------------DEKTVVRL-QEKRQKELWNLLK--------IAC---XX XXXXXXXXX--XX----------------------------------------------- ------------------------------------------------------------ ----XXXXX----XXXXXXX-XXXXXXXXXXXX-----XXX--XXXEDLVAEAHSLCTQL ESAMQDTVKE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QDQ----SFMTL-DWSWLQPEEEE-EQA------------ >X_tropicalis_ENSXETP00000036619 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MT------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------HQDASPGRAGWAPPP-------------SHTQI--CGPWEMKERLGTGG FGYVLRWIHQ--DTGEQVAIKQC-----RQ-ELSP-KNR-----ERWCLEIQIM-KKLNH PNVVSAR----EVP-----DGLQKL-APN-DLPLLAMEYCEGGDLRK--YLNQFENCCGL KEGPILTLLSDI--SSALRYLHEN-RII--HRDLKPENIVLQPG-PQRLIHKIIDLGYAK ELDQG----SLCT-SFVGTLQYL-----------------------APELLE-------- QKK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHG---KVR----EKS NEHIV--VYEDLMGAVKFSSVLPTPNHL----NSKLAGKLEHWLQCMLMWHQRQRG---- ---------------TDPQNPNV----GCFQALDSILSLKLL--------SVLNMVSGKV HTYPVSENEN--LQNLKSRLEQDTGIPE--EEQ-------ELLQASGLA---LNPAQPLT QFVVDCTVNDG-RQGEG----------DLIFLFD---NRKTVYEPQISLP---------- AHPESVTVILQD------------------------------------------------ ------------PK-RPLTYTHLRRVWGQTWQTIRAMKEDCARLLH-------------- GQRTFMVNLL-------------RYNTELSKKKNLMTSEFE---QLKAKLDF--FRNSIQ IDLEKYSEQMEFGITSEKLLSAWRETEQTV----------------EL-CGR----EREV QALVDKMM--A--------LQTDSVDLQRNP----LGR---KHR-GTLDDLEEQAKD-LY ------------RRLRER---PRDQRTAGDSNEMVRLLIQAIQSFEKR------------ ------------------------------------------------------------ ---VIL--IYDQLSKTVACKHKALELS------------PKVK---EVMNLMRE------ ----------------------DEKMVVKR-QEKRQQELWNLLK--------IAC---SK VRGPVSGSP--DS----------------------------------------------- ------------------------------------------------------------ ----LGTSR----MPGPSQL-LSQPPALSASLA----QEYV--KKSEDLLSESLKLCRQM ETSMMGFMKE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QDS----SLMSL-DWSWLSQQEEA-SGTSPITTT------ >O_latipes_ENSORLP00000003067 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MN------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------R-----------VPL-------------QQPQT--CGPWELKERLGTGG FGNVTRWQNK--DTEEQIAIKQC-----RQ-ELSE-RNK-----ERWKLEIQIM-KRLNH VNVVAAR----DVP-----AGMQKLVTAN-DLPLLAMEYCQGGDLRK--YLNVLDNCCGM REGSVLILLRDI--SSALTYLHNK-RII--HRDLKPENIVLQQG-EKRLIHKIIDLGYAK ELDQS----SLCT-SFVGTLQYL-----------------------APELIE-------- RMQ---Y-TVTVDYWSFGTLVFECITGFRPFLPTWQ--P---VPWHN---KVR----LKE NDHIV--VYEDLSGEVQFSKHLPQPNNL----NSLLLEKMERWLQLMLMWSPQNRG---- ---------------KDPNATPT----DCFSQLELILKLKLV--------HILNMMSAKI LTYSVADDET--VADLQLRIEKDTGITA--ASQ-------ELLLEAGLA---LEPHVPAS QCAVDYSEVDG-RRRDL----------PLVFLFD---RSSCTYQPQFAPR---------- TLPENIRFVQMD------------------------------------------------ ------------PK-HVLPYSPLRRTCGQAWHTIRSLKEDWQRLQQ-------------- GQKAAIMSLL-------------RHNSSLSKQKNEMVSMHQ---RLTAKLEF--FTTSLH IDMDKYQEQTATGIASEKLMSVWREMEQTA----------------VSQCGH----QAKV SELEDEMM--Q--------LQPDIVDVQRQP----W-----RCG-EALDTLEGKAME-LF ------------RKLREK---PRDQRCAGDGQEVMRLVLQAVQVYERK------------ ------------------------------------------------------------ ---LKD--FYTHLSKTAVCRQRVMELL------------PKVE---GVVQKMAE------ ----------------------SEQILMSL-QERRQKELWNLLK--------VAC---SK VRSPVSGSP--DG----------------------------------------------- ------------------------------------------------------------ ----LRTPSSVPPLLTPRDS-LQQIINPSSD------------KSDESLLEESRTFESRL QSLLHTTIQE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------SES----SMEMLREWTWLSGEESDFRCSFSHKID------ >T_nigroviridis_ENSTNIP00000019003 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MN------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------R-----------VPL-----------QQQQQQC--CGLWELRERLGNGG FGNVTRWQNK--ETEEQIAIKQC-----RQ-ELSE-RNK-----ERWCLEIEII-KRLDH VNVVAAR----EVP-----EGMQKLMAIN-DLPLLAMEYCQGGDLRK--YLNLLENCCGM REGSVLILLCDI--SSALSYLHKK-RII--HRDLKPENIVLQQG-EKRLIHKIIDLGYAK QLDHS----SLCV-SFVGTLQYL-----------------------APELIE-------- RQK---Y-TVTVDYWSFGTLVFECITGFRPFLPSWQ--P---VPWHH---KVR----LKG NNDIV--VYEDLTGEVHYCKHLPQPNNL----NSLLSGKLERWLQLMLKWSPQERG---- ---------------KDPEAAPN----DCFSQLRLILQLKLV--------HVLNMMSAKI LSYSVSEDET--VADLQLRIEADTNIPV--AKQ-------ELLLEAGLA---LEPQAPAT QCAINYSEIDG-RRTDS----------PLVFLFV---RPPCSYEPQFAPR---------- VLPENIRFVQSD------------------------------------------------ ------------PK-HVLAYSPLRRTCGQAWHTIRSLKEDWQRLQQ-------------- GQKAAIMSLL-------------RHNSSLSKQKNDMVSMYQ---RLMAKLDF--FTTSLH IDMDKYQEQTSTGIVSEKFLGTWRSMEQTA----------------VS-CS-----QAKV KELDEEMM--Q--------LQPEIVDVQRQP----W-----RSG-EALDTLEGKAME-LF ------------RKLREK---PRDQRCSGDSQEVVRLVVQAVQFYEKK------------ ------------------------------------------------------------ ---LRD--FYTHLSKTAACRQRVMELL------------PKVE---GVVQKMAE------ ----------------------SEQVLMHL-QEKRQRELWNLLK--------VAC---SK VRSPVSGSS--D------------------------------------------------ ------------------------------------------------------------ ----------VSPLLTPTHS-LQQLALITFNNG------FGCVCSDESLVEESRTFESRL QSLLHDTIQE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------STS----SMEMLSEWTWLR--------------------- >G_aculeatus_ENSGACP00000005440 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MN------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------R-----------VTL--------------QQQS--CGSWELKERLGTGG FGNVTRWQNK--DTEEQISIKQC-----RQ-ELSE-RNK-----ERWVLEIQIM-KRLDH INVVAAR----EVP-----EGMQEMITTN-DLPLLAMEYCQGGDLRK--HLNLLENCCGM REGSVLILLRDI--SSALTYLHKK-RII--HRDLKPENIVLQHG-EKRLIHKIIDLGYAK ELDQS----SLCT-SFVGTLQYL-----------------------APELIE-------- REK---Y-TVTVDYWSFGTLVFECITGFRPFLPTWQ--P---IPWHN---KLR----TKQ KDDIV--VYEDLTGEVHFSKHLPQPNDL----NSLLSERLERWLQLMLKWCPQERG---- ---------------KDPNATPS----DCFSQLEVILQLKLV--------HVLNMISAKI LTYSVSEEET--VADLQLRIEKDSNIPA--TNQ-------ELLLEAGLA---LEPHGLAT QCAVDYTEIDG-RRTDS----------PLVFLFD---RSSCSYEPQFAPR---------- TLPENIRFIQTC------------------------------------------------ ------------HK-PILAYSPLRRTCGQAWHTIRSLKDDWQRLQQ-------------- GQKAAIMSLL-------------RYNSSLSKQKNEMVSMHQ---RLMAKLDF--FTTSLH IDVDKYQEQTATGIASEKLMGVWREMEQTA----------------VS-CG-----QAKV SELEEEMM--Q--------LQPDIVDVQRQP----W-----RSG-EALDTLEGKAME-LF ------------RKLREK---PRDQRLPGDSQEVVRLVLQAVQFYERK------------ ------------------------------------------------------------ ---LRD--FYTHLSKTAVCRQRVMELL------------PKVE---GMVQSMVE------ ----------------------SEQVLMSL-QERRQRELWNLLK--------VAC---SK VRSPVSGSP--DG----------------------------------------------- ------------------------------------------------------------ ----LPTPSSVPPLLTPRHS-LQQF--------------------DESLVEESRTFEGRL QSLLHDTIQD-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------SQS----SMEVLREWTWLHSSQN-----FSSDLS------ >T_rubripes_ENSTRUP00000041917 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MN------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------R-----------VPL-------------QQQQS--CGLWELKERLGTGG FGNVTRWQNK--ETEEQIAIKQC-----RQ-ELSE-RNK-----ERWCLEIQII-KRLDH VNVVAAR----EVP-----EGMQKLMVTN-DLPLLAMEYCQGGDLRK--YLNLLENCCGM REGSVLILLCDI--SSALTYLHKK-RII--HRDLKPENIVLQQG-EKRLIHKIIDLGYAK QLDQS----SLCT-SFVGTLQYL-----------------------APELIE-------- RQM---Y-TVTVDYWSFGTLVFECITGFRPFLPSWQ--P---VPWHN---KVM----LKG DNDIV--VYENLTREVHFSKHLPQPNNL----NSLLSLKLERWLQLMLKWSPQERG---- ---------------KDPGATPS----DCFSQLEVILQLKLV--------HVLNMMSAKI LSYSVSDDET--VADLQLRIEKDTEIPV--VDQ-------ELLLEAGLA---LEPQALAM QCAIDYSQIDG-RRTDL----------PLVFLFV---RSTCSYEPQFAPR---------- TLPENISYVQSD------------------------------------------------ ------------PK-IVLAYRPLRRTCGQAWHTIRSLKEDWQRLQQ-------------- GQKAAIMSLL-------------RHNSSLSKQKNDMVSMYQ---RLMAKLDF--FTTSLH IDMDKYQEQTSTGIVYEKFLGMWRSMEQTA----------------VT-CS-----QARV SELEEEMM--Q--------LQPDIVDVQRQP----W-----RSG-EALDTLEGKAME-LF ------------RKLREK---PRDQRCSGDSQEVVRLVVQAVHFYERK------------ ------------------------------------------------------------ ---LRD--FYTHLSKTALCRQRVMELL------------PKVE---GVVQKMAE------ ----------------------SEQVLIRL-QEKRQRELWNLLK--------VAC---SK VRSPVSGSS--D------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >G_gallus_ENSGALP00000005196 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MERGAERGPPPAPGGV------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------A-----------LRG-------------QPAGG--CGPWEMRDRLGTGG FGNVCLYQHQ--DTGARVAIKSC-----RL-ELSV-KNK-----DRWCHEIDIM-KKLNH PNVVRAC----EVP-----EEMNFL--VN-DVPLLAMEYCSGGDLRK--LLNKPENCCGL KESQILSLLSDI--GSGIQYLHEN-RII--HRDLKPENIVLQDE-GGKIIHKIIDLGYAK DLDQG----SLCT-SFVGTLQYL-----------------------APELFE-------- NKS---Y-SVTVDYWSFGTMVFECIAGFRPFLHNLQ--P---FTWHE---KIK----KKD PKHIF--ASEEMNGEVRFSTHLPQPHSI----CSLIVEPMESWLQLMLNWDPEQRGG--- --------------GLDPETNSP----KCFLLMDHILNLKIV--------HILNMTSAKI VSFLLHPEES--LHFLQNRIESETGIST--GNQ-------ELLLETGIC---LDPRKPAS QCVIDGV-----RGWDS----------YMVYLFD---KSKTVYDGPFASR---------- SLSECVNYIVQD------------------------------------------------ ------------SK-IQLPIPQLRKVWAEAVHYVIGLKEDYSRLFQ-------------- GQRAAMLSLL-------------RYNANLIKMKNNMVSASQ---QLKAKLEF--FHQSIR LDLERYSDQMAYGISSEKMLKAWKEMEEKA----------------SH-CAQ----AEDI GYLDEQIM--A--------LHTEIVELQKSP----YAR---RQG-EVMESLEQRAID-LY ------------KQLKTR----PPDHAYSDSTDMVKIIVQTVQSQDRV------------ ------------------------------------------------------------ ---LKE--LFGHLSKLLGCKQKIIDLL------------PKIE---VALNNIKE------ ----------------------ADNSVMQM-QGKRQREIWHLLK--------IAC-TQSS SRSLVSSSL--EG----------------------------------------------- ------------------------------------------------------------ ----TASTPAATWVPQS-SS-EYAPHPLSSMAT----PGDG--ENFVDVIEENLNYLDRF SSMLQEAREE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QNN----SLTNF-DWSWL-K-------------------- >T_rubripes_ENSTRUP00000022821 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------ME------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------K-----------PPF-------------RQNQN--CGDWELKERLGMGG FAHVYLYQHR--ETNEKLAVKMC-----RL-ELTP-RNK-----DRWSREIQIM-KKLNH INVVTAR----DVP-----EEVTHI-SLN-DLPLLAMEYCSRGDLRK--MLSKPENCCGL KESEVLSLINDV--GSGIQYLHKN-KII--HRDLKPENIVLQDI-SGKLVHKIIDLGYAK DLDQG----SLCT-SFVGTLQYL-----------------------APELFE-------- NKP---Y-TVTVDYWSFGTMLFECSCGFRPFLHNLQ--P---VQWAS---KVR----NKG PKDIM--AVEELNGEVKFSTQLPYPNNL----SRTLLKPMEALLQLMLNWDPVQRGG--- --------------RVSPESKKP----LCFEVLEQILSMKVV--------HILNMTTAQV HSFQLTADEN--LHSLQKRIEAETKIDV--ANQ-------ELLQETGVS---LDPRKPAA QCVLDGVLNEH-RGWDS----------YIVYLFD---KSITTYSGPFSAR---------- QLSDKVHTIVQD------------------------------------------------ ------------AK-KQLPLVVLKKIWGEAVSYICGLKEDYSRLFQ-------------- GQRAAMLSLL-------------RYNTNLTRCKNNMFGFSQ---QLKAKLDF--FKSSIQ YDLEKYSDQMHYGISSEKMLKAWQENEERA----------------AA-FAQ----VAEV NHLDDEIL--A--------LHSEIVELQRSP----YAR---RQG-DKMEQLEEKAIE-LY ------------KQLKMKCKTPETDMS-TDSTEMVKAIIQTVQNQDKV------------ ------------------------------------------------------------ ---LKD--LYTHLSKILISKQKIIDLF------------PRIE---KTLENIKD------ ----------------------ADTTVMQM-QIKRQREFWHLLK--------IAC-AQNS SRSSMAASP--ES----------------------------------------------- ------------------------------------------------------------ ----STMLQVSQWSQSAQPV--SSPHPLTSLPG----PNDS--DAAPRLLQENQRYLSQL TSLMQEAADE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QSK----SIVDQ-DWSWTKYETLTDKLKKRNA-------- >R_norvegicus_ENSRNOP00000034134 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------ME------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------R-----------PPG-------------LRPGA--GGPWEMRERLGTGG FGNVSLYQHR--ELDLKIAIKSC-----RL-ELST-KNR-----ERWCHEIQIM-KKLNH ANVVKAC----DVP-----EELNFL--IN-DVPLLAMEYCSGGDLRK--LLNKPENCCGL KESQILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV-GGKIMHKIIDLGYAK DVDQG----SLCT-SFVGTLQYL-----------------------APELFE-------- NKP---Y-TATVDYWSFGTMVFECIAGYRPFLHHLQ--P---FTWHE---KIK----KKD PKCIF--ACEEMTGEVRFSSHLPQPNNL----CSLIVEPMESWLQLMLNWDPQQRGG--- --------------PIDPPLKQP----KCFVLMDNILNLKIV--------HILNMTSAKI ISFLLPYDES--LHSLQSRIERETGINT--GSQ-------ELLSETGIS---LDPRKPAS QCVLDGV-----RGCDS----------YMVYLFD---KSKTVYEGPFASR---------- SLSDCVNYIVQD------------------------------------------------ ------------SK-IQLPVTQLRKVWAEAVHYVSGLKEDYSRLFQ-------------- GQRAAMLSLL-------------RYNANLTKMKNTLISASQ---QLKAKLEF--FRKSIQ LDLERYSEQMTYGISSEKMLKAWKEMEEKA----------------IH-YSE----VGVI GYLEDQIM--S--------LHTEIMELQKSP----YGR---RQG-DLMESLEQRAID-LY ------------KQLKHR----PTDHSYSDSTEMVKIIVHTVQSQDRV------------ ------------------------------------------------------------ ---LKE--LFGHLSKLLGCKQKIIDLL------------PKVE---VALSNIKE------ ----------------------ADNTVMFM-QGKRQKEIWHLLK--------IAC-TQSS ARSLVGSSL--EG----------------------------------------------- ------------------------------------------------------------ ----TVTPPVSAWLPPT-LA--DREHPLTCVVT----PQDG--ETLAQMIEENLNCLGHL STIIREANED-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QSS----SMMSL-DWSWLAE-------------------- >P_troglodytes_ENSPTRP00000055512 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------ME------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------R-----------PPG-------------LRPGA--GGPWEMRERLGTGG FGNVCLYQHR--ELDLKIAIKSC-----RL-ELST-KNR-----ERWCHEIQIM-KKLNH ANVVKAC----DVP-----EELNIL--IH-DVPLLAMEYCSGGDLRK--LLNKPENCCGL KESQILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV-GGKIIHKIIDLGYAK DVDQG----SLCT-SFVGTLQYL-----------------------APELFE-------- NKP---Y-TATVDYWSFGTMVFECIAGYRPFLHHLQ--P---FTWHE---KIK----KKD PKCIF--ACEEMSGEVRFSSHLPQPNSL----CSLIVEPMENWLQLMLNWDPQQRGG--- --------------PVDFTLKQP----RCFVLMDHILNLKIV--------HILNMTSAKI ISFLLPPDES--LHSLQSRIERETGINT--GSQ-------ELLSETGIS---LDPRKPAS QCVLDGV-----RGCDS----------YMVYLFD---KSKTVYEGPFASR---------- SLSDCVNYIVQD------------------------------------------------ ------------SK-IQLPIIQLRKVWAEAVHYVSGLKEDYSRLFQ-------------- GQRAAMLSLL-------------RYNANLTKMKNTLISASQ---QLKAKLEF--FHKSIQ LDLERYSEQMTYGISSEKMLKAWKEMEEKA----------------IH-YAE----VGVI GYLEDQIM--S--------LHAEIMELQKSP----YGR---RQG-DLMESLEQRAID-LY ------------KQLKHR----PSDHSYSDSTEMVKIIVHTVQSQDRV------------ ------------------------------------------------------------ ---LKE--LFGHLSKLLGCKQKIIDLL------------PKVE---VALSNIKE------ ----------------------ADNTVMFM-QGKRQKEIWHLLK--------IAC-TQSS ARSLVGSSL--EG----------------------------------------------- ------------------------------------------------------------ ----AVTPQTSAWLPPT-SA--EHDHSLSCVVT----PQDG--ETSAQMIEENLNCLGHL STIIHEANEE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QGS----SMMNL-DWSWLTE-------------------- >H_sapiens_ENSP00000359424 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------ME------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------R-----------PPG-------------LRPGA--GGPWEMRERLGTGG FGNVCLYQHR--ELDLKIAIKSC-----RL-ELST-KNR-----ERWCHEIQIM-KKLNH ANVVKAC----DVP-----EELNIL--IH-DVPLLAMEYCSGGDLRK--LLNKPENCCGL KESQILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV-GGKIIHKIIDLGYAK DVDQG----SLCT-SFVGTLQYL-----------------------APELFE-------- NKP---Y-TATVDYWSFGTMVFECIAGYRPFLHHLQ--P---FTWHE---KIK----KKD PKCIF--ACEEMSGEVRFSSHLPQPNSL----CSLVVEPMENWLQLMLNWDPQQRGG--- --------------PVDLTLKQP----RCFVLMDHILNLKIV--------HILNMTSAKI ISFLLPPDES--LHSLQSRIERETGINT--GSQ-------ELLSETGIS---LDPRKPAS QCVLDGV-----RGCDS----------YMVYLFD---KSKTVYEGPFASR---------- SLSDCVNYIVQD------------------------------------------------ ------------SK-IQLPIIQLRKVWAEAVHYVSGLKEDYSRLFQ-------------- GQRAAMLSLL-------------RYNANLTKMKNTLISASQ---QLKAKLEF--FHKSIQ LDLERYSEQMTYGISSEKMLKAWKEMEEKA----------------IH-YAE----VGVI GYLEDQIM--S--------LHAEIMELQKSP----YGR---RQG-DLMESLEQRAID-LY ------------KQLKHR----PSDHSYSDSTEMVKIIVHTVQSQDRV------------ ------------------------------------------------------------ ---LKE--LFGHLSKLLGCKQKIIDLL------------PKVE---VALSNIKE------ ----------------------ADNTVMFM-QGKRQKEIWHLLK--------IAC-TQSS ARSLVGSSL--EG----------------------------------------------- ------------------------------------------------------------ ----AVTPQTSAWLPPT-SA--EHDHSLSCVVT----PQDG--ETSAQMIEENLNCLGHL STIIHEANEE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QGN----SMMNL-DWSWLTE-------------------- >M_mulatta_ENSMMUP00000024306 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------ME------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------R-----------PPG-------------LRPGA--GGPWEMRERLGTGG FGNVCLYQHR--ELDLKIAIKSC-----RL-ELST-KNR-----ERWCHEIQIM-KKLNH ANVVKAC----DVP-----EELNIL--IH-DVPLLAMEYCSGGDLRK--LLNKPENCCGL KESQILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV-GGKIIHKIIDLGYAK DVDQG----SLCT-SFVGTLQYL-----------------------APELFE-------- NKP---Y-TATVDYWSFGTMVFECIAGYRPFLHHLQ--P---FTWHE---KIK----KKD PKCIF--ACEEMSGEVRFSSHLPQPNSL----CSLIVEPMENWLQLMLNWDPQQRGG--- --------------PVDLTLKQP----RCFVLMDHILNLKIV--------HILNMTSAKI ISFLLPPDES--LHSLQSRIERETGINT--GSQ-------ELLSETGIS---LDPRKPAS QCVLDGV-----RGCDS----------YMVYLFD---KSKTVYEGPFASR---------- SLSDCVNYIVQD------------------------------------------------ ------------SK-IQLPIVQLRKVWAEAVHYVSGLKEDYSRLFQ-------------- GQRAAMLSLL-------------RYNANLTKMKNTLISASQ---QLKAKLEF--FHKSIQ LDLERYSEQMTYGISSEKMLKAWKEMEEKA----------------IH-YAE----VGVI GYLEDQIM--S--------LHAEIMELQKSP----YGR---RQG-DLMESLEQRAID-LY ------------KQLKHR----PSDHSYSDSTEMVKIIVHTVQSQDRV------------ ------------------------------------------------------------ ---LKE--LFGHLSKLLGCKQKIIDLL------------PKVE---VALSNIKE------ ----------------------ADNTVMFM-QGKRQKEIWHLLK--------IAC-TQSS ARSLVGSSL--EG----------------------------------------------- ------------------------------------------------------------ ----AVTPQTSVWLPPT-SA--EHDHSLSCVVT----PQDG--DTSAQMIEENLNCLGHL STIIHEANEE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QGN----SMMNL-DWSWLTE-------------------- >D_rerio_ENSDARP00000013115 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------ME------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------K-----------PPF-------------RQNQV--CGSWVMKERLGTGG FGHVYLYQNQ--ETSEKIAVKLC-----RL-ELNS-KNK-----DRWSREIQIM-KKLKH LNVVTAK----DVP-----EEMMHI-ALN-DLPLLAMEYCSKGDLRK--LLSKPENCCGL KESEVLSLLNDI--GSGIQYLHEN-KII--HRDLKPENIVLQEI-NGKLVHKIIDLGYAK DLDQG----SLCT-SFVGTLQYL-----------------------APELFE-------- GKS---Y-TVTVDFWSFGTMIFECCCGFRPFLHNLQ--P---VQWTS---KVR----NKG PKDIM--AVEDMNGEVRFSTHLPYPNNL----SRTLLEPLEGLLQLMLKWDPVQRGL--- --------------GLNTDSKQP----QCFVLLDQILSMKVV--------HILNMTTTQV HSFLLSPDEG--LHSLQQRIENETKIEL--LNQ-------DLLQETGVM---LDPRKPAA QCVLDGV-----RGWDS----------YIVYLFD---KSLTKYMGPLTAR---------- TLPESVNFIVRE------------------------------------------------ ------------TK-TQLPLSTLKKVWGEAVSYICGLREDYSRLFQ-------------- GQRAAMLSLL-------------RFNTNLTRYKNMMFSFSQ---QLKAKLDF--FKTSIQ YDLEKYSDQMQYGISSEKMLKAWHENEERA----------------AA-FAQ----VAEI GHLDEEIM--A--------LHSEIVELQRSP----YAR---RQG-DVMEQLQEKAIE-LY ------------KQLKAKCKMPDPQHGYSDSSEMVKVIVQTVQNQDRV------------ ------------------------------------------------------------ ---LRD--LYAHLSKILLSKQKIIDLF------------PKIE---RTLECIKE------ ----------------------ADTTVMQM-QIKRQREFWHLLK--------IAC-AQNT TRSSVSQSG--EM----------------------------------------------- ------------------------------------------------------------ ----PSSL--STWNQTQAQC--SSRLPM-SLQV----PHEG--DSVNHLLEENQRYLTQL TSLLQETTEE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KSE----SIMAQ-DWSWTKYESLVAKSPRL---------- >C_familiaris_ENSCAFP00000014093 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------ME------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------R-----------PPG-------------LRPGA--GGPWEMRERLGTGG FGNVCLYQHR--ELDVKIAIKSC-----RL-ELST-KNR-----ERWCHEIQIM-KKLNH ANVVKAC----DVP-----EELNFL--IN-DVPLLAMEYCSGGDLRK--LLNKPENCCGL KESQILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV-GGKIMHKIIDLGYAK DVDQG----SLCT-SFVGTLQYL-----------------------APELFE-------- NKP---Y-TATVDYWSFGTMVFECIAGYRPFLHHLQ--P---FTWHE---KIK----KKD PKCIF--ACEEMTGEVRFSSHLPQPNSL----CSLIVEPMENWLQLMLNWDPQQRGG--- --------------PVDLTLKQP----RCFVLMDHILNLKIV--------HILNMTSAKI ISFLLPPDES--LHSLQSRIERETGINT--GSQ-------ELLSETGIS---LDPRKPAS QCVLDGV-----RGCDS----------YMVYLFD---KSKTVYEGPFASR---------- SLSDCVNYIVRD------------------------------------------------ ------------SK-IQLPIIQLRKVWAEAVHYVSGLKEDYSRLFQ-------------- GQRAAMLSLL-------------RYNANLTKMKNTLISASQ---QLKAKLEF--FHKSIQ LDLERYSEQMTYGISSEKMLKAWKEMEEKA----------------IH-YAE----VGVI GYLEDQIM--S--------LHTEIMELQKSP----YGR---RQG-DLMESLEQRAID-LY ------------KQLKHR----PSDHSYSDSTEMVKIIVHTVQSQDRV------------ ------------------------------------------------------------ ---LKE--LFGHLSKLLGCKQKIIDLL------------PKVE---MALSNIKE------ ----------------------ADNTVMFM-QGKRQKEIWHLLK--------IAC-TQSS ARSLVGSSL--EG----------------------------------------------- ------------------------------------------------------------ ----AVTPQASAWLPPN-SA--EREHPLSCVVT----PQDG--ETIVQMIEENLNCLGHL STIIHEANEE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QGS----RMMNL-DWSWLTE-------------------- >B_taurus_ENSBTAP00000009985 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------RNSGGASGRSPSRPME------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------R-----------PPG-------------LRPGA--GGPWEMRERLGTGG FGNVCLYQHR--ELDLKIAIKSC-----RL-ELST-KNR-----ERWCHEIQIM-KKLNH ANVVKAC----DVP-----EELNFL--IN-DVPLLAMEYCSGGDLRK--LLNKPENCCGL KESQILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV-GGKIMHKIIDLGYAK DVDQG----SLCT-SFVGTLQYL-----------------------APELFE-------- NKP---Y-TATVDYWSFGTMVFECIAGYRPFLHHLQ--P---FTWHE---KIK----KKD PKCIF--ACEEMTGEVRFSSHLPQPNSL----CSLIVEPMENWLQLMLNWDPQQRGG--- --------------PVDLTLKQP----RCFVLMDHILNLKIV--------HILNMTSAKI ISFLLPPDES--LHSLQSRIERETGINT--GSQ-------ELLSEMGIS---LDPRKPAS QCVLDGV-----RGCDS----------YMVYLFD---KSKTVYEGPFASR---------- SLSDCVNYIVQD------------------------------------------------ ------------SK-IQLPIIQLRKVWAEAVHYVSGLKEDYSRLFQ-------------- GQRAAMLSLL-------------RYNTNLTKMKNTLISASQ---QLKAKLEF--FHKSIQ LDLERYSEQMTYGISSEKMLKAWKEMEEKA----------------IH-YAE----VGVI GYLEDQIM--S--------LHTEIMELQKSP----YGR---RQG-DLMESLEQRAID-LY ------------KQLKHR----PSDHSYSDSTEMVKIIVHTVQSQDRV------------ ------------------------------------------------------------ ---LKE--LFGHLSKLLGCKQKIIDLL------------PKVE---MALSNIKE------ ----------------------ADSTVMFM-QGKRQKEIWHLLK--------IAC-TQSS ARSLVGSSL--EG----------------------------------------------- ------------------------------------------------------------ -----VTPQ----LPPT-SA--EREHPLSCVVT----PQDG--ETLAQMIEENLNCLGHL STIIHEANEK-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QGN----NMMSL-DWSWLTE-------------------- >M_musculus_ENSMUSP00000026217 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------ME------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------R-----------PPG-------------LRPGA--GGPWEMRERLGTGG FGNVSLYQHR--ELDLKIAIKSC-----RL-ELSS-KNR-----ERWCHEIQIM-KKLDH ANVVKAC----DVP-----EELNFL--IN-DVPLLAMEYCSGGDLRK--LLNKPENCCGL KESQILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV-GGKTIHKIIDLGYAK DVDQG----SLCT-SFVGTLQYL-----------------------APELFE-------- NKP---Y-TATVDYWSFGTMVFECIAGYRPFLHHLQ--P---FTWHE---KIK----KKD PKCIF--ACEEMTGEVRFSSHLPQPNSL----CSLIVEPMESWLQLMLNWDPQQRGG--- --------------PIDLTLKQP----RCFALMDHILNLKIV--------HILNMTSAKI ISFLLPCDES--LHSLQSRIERETGINT--GSQ-------ELLSETGIS---LDPRKPAS QCVLDGV-----RGCDS----------YMVYLFD---KSKTVYEGPFASR---------- SLSDCVNYIVQD------------------------------------------------ ------------SK-IQLPIIQLRKVWAEAVHYVSGLKEDYSRLFQ-------------- GQRAAMLSLL-------------RYNANLTKMKNTLISASQ---QLKAKLEF--FRKSIQ LDLERYSEQMTYGISSEKMLKAWKEMEEKA----------------IH-YSE----VGVI GYLEDQIM--S--------LHTEIMELQKSP----YGR---RQG-DLMESLEQRAID-LY ------------KQLKHR----PPDHLYSDSTEMVKIIVHTVQSQDRV------------ ------------------------------------------------------------ ---LKE--LFGHLSKLLGCKQKIIDLL------------PKVE---VALSNIKE------ ----------------------ADNTVMFM-QGKRQKEIWHLLK--------IAC-TQSS ARSLVGYSL--EG----------------------------------------------- ------------------------------------------------------------ ----TVTPPVSAWLPPT-LA--DREHPLTCVVT----PQDG--ETLAQMIEENLNCLGHL STIIREANED-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QSS----SLMSL-DWSWLAE-------------------- >M_domestica_ENSMODP00000013213 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------WEMRERLGTGG FGNVCLYQHR--ELGNKIAIKSC-----RL-ELSA-KNK-----DRWCHEIQIM-KKLNH PSVVKAC----DVP-----EEMNFL--IN-DVPLLAMEYCSGGDLRK--LLNKPENCCGL KESQILSLLSDI--GSGIQYLHEN-RII--HRDLKPENIVLQDV-GGKVIHKIIDLGYAK DLDQG----SLCT-SFVGTLQYL-----------------------APELFE-------- NKP---Y-TATVDYWSFGTMVFECIVGYRPFLHHLQ--P---FTWHE---KIK----KKD PKHIF--AFEEMTGEVRFSSHLPQPNSL----SSFIVQPMEQWLQLMLTWDPQQRGG--- --------------SLDLPHKQP----ACFGQMEQILNLKIA--------HILNMTSAKI ISFLLFPEES--LHSLQSRIEHETGINT--ASQ-------ELLLEMGIS---LDPRKPAS QCVLDGV-----RGCDS----------YMVYLFD---KSKIVYEGPFASR---------- SLSECVNYIVKD------------------------------------------------ ------------SK-IQLPVMQLRRVWAEAVHYVSGLKEDYSRLFQ-------------- GQRAAMLSLL-------------RYNANLTKMKNTMISASQ---QLKAKLQF--FHQSIQ LDLDRYSDQMTYGISSEKMLKAWKEMEEKA----------------IQ-CAQ----AGDI GYLDEQIM--S--------LHTEIVELQRSP----SAR---RQE-DVMESLEQKAID-LY ------------KQLKPR----SPDHSYSDSSEMVKIIVLTVQNQDRV------------ ------------------------------------------------------------ ---LKE--LFGHLSKLLGCKQKIIDLL------------PKIE---VALNSIKE------ ----------------------ADNMVMLM-QGKRQREIWHLLK--------IAC-TQSS ARSLVGTSL--EG----------------------------------------------- ------------------------------------------------------------ ----AATSPPSAGLPSALTA--PMPRSLSCVLS----AQDG--ETFTQIVEENLNYLGCL STVIREATEE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QGK----NLMSL-DWSWLK--------------------- >T_guttata_ENSTGUP00000004836 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------GPWEMRDRLGTGG FGNVCLYQHQ--DSGDRVAIKSC-----RL-ELSV-KNK-----DRWCHEIDIM-KKLNH PNVVRAC----EVP-----EEMNFL--VN-DVPLLAMEYCSGGDLRK--LLNKPENCCGL KESQILSLLSDI--GSGIQYLHEN-RII--HRDLKPENIVLQDE-GGKIVHKIIDLGYAK DLDQG----SLCT-SFVGTLQYL-----------------------APELFE-------- NKS---Y-SVTVDYWSFGTMVFECIAGFRPFLHNLQ--P---FAWHE---KIK----KKD PKHIF--ASEEMNGEVRFSTHLPQPHSL----CGLIVEPMENWLQLMLNWDPQQRGG--- --------------GSDAETGRP----RCFLMMDHILNLKIV--------HILNMTSAKI VSFLLHPEES--LHSLQNRIEFETGIST--GNQ-------ELLLETGIC---LDPRKPAS QCVIDGV-----RGWDS----------YMVYLFD---KSKTVYDGPFASR---------- SLSDCVNYIVQD------------------------------------------------ ------------SK-IQLPIPQLRKVWAEAVHYVIGLKEDYSRLFQ-------------- GQRAAMLSLL-------------RYNANLIKMKNNMVSASQ---QLKAKLEF--FHQSIR LDLERYSDQMAYGISSEKMLKAWKEMEEKA----------------SQ-CAQ----AEDI GYLDEQIM--A--------LHTEIVELQKSP----YAR---RQG-EVMESLEQRAID-LY ------------KQLKAR----PPDHAYSDSTDMVKIIVQTVQSQDRV------------ ------------------------------------------------------------ ---LKE--LFGHLSKLLGCKQKIIDLL------------PEIE---VALNNIKE------ ----------------------ADNSVMQM-QGKRQREIWHLLK--------IAC-TQSS SRSLVSSSL--EG----------------------------------------------- ------------------------------------------------------------ ----TASSPAATWLPQS-SS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >O_latipes_ENSORLP00000016017 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------ME------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------K-----------PPF-------------RQNVN--CGDWEMKERLGMGG FAHVYLYQHC--ATNEKLAVKMC-----RL-ELTP-RNR-----DRWSREIQIM-KKLNH INVVTAQ----DVP-----EEMKRI-ALN-DLPLLAMEYCSRGDLRK--VLSKPENCCGL KESEVLSLLSDV--GSGIQYLHEN-KII--HRDLKPENIVLQ------LVHKIIDLGYAK DLDQG----SLCT-SFVGTLQYL-----------------------APELFE-------- NKP---Y-TVTVDYWSFGTMIFECSCGFRPFLHNLQ--P---VQWAS---KVK----NKG PKDIM--AVEELNGEVRFSTHLPYPNNL----SRTLLEPMETLLQLMLKWDPVQRGG--- --------------RVNSDTKKP----MCFEVLEQILSMRVV--------HILNMTTAQV HSFQLSPDES--LHSLQKRIEGETKIEV--VNQ-------ELLHETGVS---LDPRKPAA QCALDGVKKSLKRGWDS----------YVVYLFD---KSLTKYSGPFSAR---------- RLPEKVNTIVQE------------------------------------------------ ------------PK-TQLPLVVLKKVWGEAVSYICGLKEDYCRLFQ-------------- GQRAAMLSLL-------------RYNTNLTRCKNSMFGFSQ---QLKAKLDF--FKSSIQ YDLEKYSDQMHYGISSEKMLKAWQENEERA----------------AA-FAQ----VAEV SHLDDEIM--A--------LHSEIVELQRSP----YAR---RQG-DKMEQLEEKAIE-LY ------------RQLKMKCKIPDSDVS-SDSSEMVKAIIQTVQNQDKV------------ ------------------------------------------------------------ ---LKD--LYTHLSKILISKQKIIDLF------------PRIE---KTLENIKD------ ----------------------ADNTVMQM-QIKRQREFWHLLK--------IAC-AQNS SRNSIAVSP--ES----------------------------------------------- ------------------------------------------------------------ ----SNLLQVSQWSQSAQPV--SSPHPLVSLPG----PNDS--DAAPRLLQENQKYLSQL TSLMQEAADD-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QAK----SIVDQ-DWSWTKYESLSTKLKKQNA-------- >G_aculeatus_ENSGACP00000005520 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------ME------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------K-----------PPF-------------RQNQN--CGDWELKERLGMGG FGHVYLYQHH--KTNEKLAVKMC-----RL-ELTP-RNK-----DRWSREIQIM-KKLNH INVVSAQ----DVP-----EEMRHI-ALN-DLPLLAMEYCSRGDLRK--ILSKPENCCGL KESEVLSLLNDV--GSGIQYLHEN-KII--HRDLKPENIVLQDI-NGKLVHKIIDLGYAK DLDQD----SLCT-SFVGTLQYL-----------------------APELFE-------- NHP---Y-TVTVDYWSFGTMMFECICGFRPFLHNLQ--P---VQWAT---KVK----NKG PRDIT--AVEEPNGEVTFSTHLPYPNNL----SSTMLGPIEKLLQLMLRWDPFHRGG--- --------------PVNRETKRP----SCFEQLELILSMKVV--------HILNMTTAQV HSFQLDPEES--LHSLQKRIEAETRIEV--VNQ-------ELLQETGVS---LDPRKPAA QCVLDGV-----RGWDS----------YIVYLFD---KSINKYSGPLSAR---------- KLPDKVNMIVQE------------------------------------------------ ------------AK-TELPLVALKMVWGEAVSYICGLKDDYSRLFQ-------------- GQRAAMVSLP-------------RYNTNLNRCKNSMFGFSQ---QLKAKLDF--FKSSLP YDLEKYSDQMHYGISSEKMLKAWQENEERA----------------AA-FAQ----VAEV SHLDDEIM--A--------LHSEIVELQRSP----YAR---RQG-DKMEQLEEKAIE-LY ------------KQMKMKCKTPEPDVS-SDSSQMVMAIIQTVQNQDKV------------ ------------------------------------------------------------ ---LKD--LYTHLSKILISKQKIIDLF------------PRIE---KTLESIKD------ ----------------------ADNTVMQM-QIKRQREFWHLLK--------IAC-AQNL TRNSIAASP--ES----------------------------------------------- ------------------------------------------------------------ ----SNLLQVSQWSQSAQPV--SSPHPLTSLPG----PNDS--DAAPRLLQENERYLCQL TSLMQEATDE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QTK----SIVEQ-DWSWTKYETLTTKLKKRNP-------- >P_pygmaeus_ENSPPYP00000002975 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------ME------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------R-----------PPG-------------LRPGA--GGPWEMRERLGTGG FGNVCLYQHR--ELDLKIAIKSC-----RL-ELST-KNR-----ERWCHEIQIM-KKLNH ANVVKAC----DVP-----EELNIL--IH-DVPLLAMEYCSGGDLRK--LLNKPENCCGL KESQILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV-GGKIIHKIIDLGYAK DVDQG----SLCT-SFVGTLQYL-----------------------APELFE-------- NKP---Y-TATVDYWSFGTMVFECIAGYRPFLHHLQ--P---FTWHE---KIK----KKD PKCIF--ACEEMSGEVRFSSHLPQPNSL----CSLIVEPMENWLQLMLNWDPQQRGG--- --------------PVDLTLKQP----RCFVLMDHILNLKIV--------HILNMTSAKI ISFLLPPDES--LHSLQSRIERETGINT--GSQ-------ELLSETGIS---LDPRKPAS QCVLDGV-----RGCDS----------YMVYLFD---KSKTVYEGPFASR---------- SLSDCVNYIVQD------------------------------------------------ ------------RQNTSFQLYRLRKVWAEAVHYVSGTKKNYSRLFQ-------------- GQKGLGLSLL-------------RYNANLTKMKNTLISASQ---QLKAKLEF--FHKSIQ LDLERYSEQMTYGICQKKMLKAWKEMEEKA----------------IH-YAE----VGVI GYLEDQIM--S--------LHAEIMELQKEP----LWK---RQG-DLMESLEQRAID-LY ------------KQLKHR----PSDHSYSDSTEMVKIIVHTVQSQDRV------------ ------------------------------------------------------------ ---LKE--LFGHLSKLLGCKQKIIDLL------------PKVE---VALSNIKE------ ----------------------ADNTVMFM-QGKRQKEIWHLLK--------IAC-TQSS ARSLVGSSL--EG----------------------------------------------- ------------------------------------------------------------ ----AVTPQASAWLPPT-SA--EHDHSLSCVVT----PQDG--ETSAQMIAENLNCLGHL STIIHEANEE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QGS----SMMNL-DWSWLTE-------------------- >X_tropicalis_ENSXETP00000038296 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------ME------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------K-----------PPV-------------QHGAV--CGPWDMKDRLGTGG FGNVCLYQNR--ETGELKAIKSC-----RL-ELSM-KNK-----ERWCQEIQIM-KRLNH PNVVKAC----EVP-----PEMDFL--VN-DVPHLAMEYCAGGDLRK--LLNKPENCCGL KESQVLNLMSDI--GSGIQYLHEK-RII--HRDLKPENIVLQEC-NGKTVHKIIDLGYAK DLDQG----SLCT-SFVGTLQYL-----------------------APELFE-------- NKP---Y-SVTVDYWSFGTMVFECIAGFRPFLHNMQ--P---FTWHE---KIK----KKD HKHIY--AYEEMSGEIRFSSYLPQPNNL----CSIIVDKIETWLQLLLNWDPIQRGG--- --------------GMD--CGRP----QCFVLMDQILNLKIV--------HILNMTSAKI HSFHL-QEES--LHTLQSRIETETGIST--CNQ-------ELLLEMGVS---LDPRKPAS QCVIDGV-----KGWDS----------YMVYLFD---KSKTVYEGPFQSR---------- SLSECLNYIVQD------------------------------------------------ ------------SK-VQLPIPQLRKVWAEAVHYVSGLKEDYSRLFQ-------------- GQRAAMLSLL-------------RFNTNLTKMKNTMVSASQ---QLGAKLQF--FKRSIE IDLERYSDQMAYGISSEKMLRAWKEMEDKA----------------VC-FGK----AGKI HFLDETIM--G--------LHTEIVELQKSP----CAR---RQG-DVMEHLEQRAME-LY ------------KQLKPR----SPDKAYSDSTEMVKILVQTVQGQDRV------------ ------------------------------------------------------------ ---LKE--LFGHLSKLLGCKQKIIDLL------------PQIE---MTVNNIKE------ ----------------------ADSSLMQM-QAKRQREIWHLLK--------IAC-TQSS ARSLGPASV--ET----------------------------------------------- ------------------------------------------------------------ ----PITPRTSAWPDQS-SS-----QALFSMLT----TKDKSREILRHTIDKNSDYQKLL SSLILQTQTT-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------MEQN----SLMSL-DFSWLNK-------------------- >T_nigroviridis_ENSTNIP00000014802 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------ME------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------K-----------PPF-------------RQNQN--CGDWELKERLGMGG FGHVYLYQHR--ETNEKLAVKMC-----RL-DLTP-KNK-----DRWSREIQIM-KKLNH INVVTAR----DVP-----EEMKHI-SLN-DLPLLAMEYCSRGDLRK--MLSKPENCCGL KESEVLSLLNDV--GSGIQYLHKN-KII--HRDLKPENIVLQDI-SGKLVHKIIDLGYAK DLDQG----SLCT-SFVGTVQYL-----------------------APELFE-------- NKP---Y-TVTVDYWSFGTMLFECSCGFRPFLHNLQTSA---VLRAS---KVR----NKG PKDIM--AVEELNGEVKFSTQLPYPNNL----SRTLLKPMEALLQLMLNWDPVQRGG--- --------------RVNPETKKP----LCFEVLEQILSMKVV--------HILNMTTAQV HSFQLAADEN--LHSLQKRIEAETKIEV--ANQ-------ELLQETGVS---LDPRKPAA QCVLDGV-----RGWDS----------YIVYLFD---KSITTYSGPFSAR---------- QLSDKVHTIVQE------------------------------------------------ ------------AK-KQLPLEVLKKIWGEAVSYICGLKEDYSRLFQ-------------- GQRAAMLSLL-------------RYNTNLTRCKNNMFGFSQ---QLKAKLDF--FKSSIQ YDLEKYSDQMHYGISSEKMLKAWQENEERA----------------AA-FAQ----VAEV NHLDDEIL--A--------LHSEIVELQRSP----YAR---RQG-DKMEQLEEKAIE-LY ------------KQLKMRCKTPETDTS-TDSTEMVKAIIQTVQNQDKV------------ ------------------------------------------------------------ ---LKD--LYTHLSKILISKQKIIDLF------------PRIE---KALENIKD------ ----------------------ADTTVMQM-QTKRQREFWHLLK--------IAC-AQNS SRSSIAASP--ES----------------------------------------------- ------------------------------------------------------------ ----STMLQVSQWSQSAQPV--SSPHPLTSLPG----PNDS--DAAPRLLQENQRYLSQL TSLMQEGCGR-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------TVQKGVSSFKDQ-DWSWTKYETLSTKLKKR---------- >A_carolinensis_ENSACAP00000011973 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------KLAIKSC-----RL-ELSV-KNK-----DRWCHEIQIM-KKLNH PNIVKAC----DVP-----EEMNFL--VN-DVPLLAMEYCSKGDLRK--LLNLPENCCGL KESQILNLLSDI--GSGIQYLHEN-RII--HRDLKPENIVLQDE-GGKIIHKIIDLGYAK DLDQG----SLCT-SFVGTLQYL-----------------------APELFD-------- NKP---Y-TASVDFWSFGTVVFECITGFRPFLHNQQ--P---FTWHD---KIK----KKD PKCIF--AWEEMTGEVRFSAHLPNPNSL----CSIIVELMESWLQLMLNWDPQQRGG--- --------------GRDPETGNF----RCFQLMDHLLNLKIV--------HILNMTSAKI LSFSLHPEES--LHSLQSRIESETGIST--GNQ-------DLLLEMGIC---LDPRKPAS QCVIDGI-----RGWDS----------YMVYLFD---KSKTIYEGPFASR---------- SLSDCVNYIVQD------------------------------------------------ ------------SK-IQLPILQLRKIWAEAVYYVIGLKEDYSRLFQ-------------- GQRAAMLSLL-------------RYNANLTKMKNNMVSASQ---QLRAKLKF--FQQSIH LDLERYSDQMTYGISSEKMLKAWKEMEEKA----------------LL-CEQ----AGDI GYLDEQIM--A--------LHTEIVELQRSP----HAR---RQG-DLMENLEQRAIE-LY ------------KQLKRR----PPDHSYSDSTEMVKIIVQTVQSQDWV------------ ------------------------------------------------------------ ---LKE--LFRHLSKLLDCKQKIIDLL------------PKIE---VALNNIKE------ ----------------------ADNSVMQM-QGKRQKEIWHLLK--------IAC-TQSS AKSPVSSN----G----------------------------------------------- ------------------------------------------------------------ ----EVTSSVPACLSQT-PS-GNVLQPLSSMET----SRNL--VPFAHLIEENLSYLHSF STVIQEATHG-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QSS----SLKSL-DWSWL---------------------- >E_caballus_ENSECAP00000005937 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ELDLKIAIKSC-----RL-ELST-KNR-----ERWCHEIQIM-KKLNH ANVVKAC----DVP-----EELNFL--IN-DVPLLAMEYCSGGDLRK--LLNKPENCCGL KESQILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV-GGKIMHKIIDLGYAK DVDQG----SLCT-SFVGTLQYL-----------------------APELFE-------- NKP---Y-TATVDYWSFGTMVFECIAGYRPFLHHLQ--P---FTWHE---KIK----KKD PKCIF--ACEEMTGEVRFSSHLPQPNSL----CSLIVEPMEHWLQLMLNWDPQQRGG--- --------------PVDLTLKQP----RCFVLMDHILNLKIV--------HILNMTSAKI ISFLLPPDES--LHSLQSRIERETGINT--GSQ-------ELLSETGIS---LDPRKPAS QCVLDGV-----RGCDS----------YMVYLFD---KSKTVYEGPFASR---------- SLSDCVNYIVQD------------------------------------------------ ------------SK-IQLPIIQLRKVWAEAVHYVSGLKEDYSRLFQ-------------- GQRAAMLSLL-------------RYNANLTKMKNTLISASQ---QLKAKLEF--FHKSIQ LDLERYSEQMTYGISSEKMLKAWKEMEEKA----------------IH-YAE----VGVI GNLEEQIM--S--------LHTEIMELQKSP----YGR---RQG-DLMESLEQRAID-LY ------------KQLKHR----PSDHSYSDSTEMVKIIVHTVQSQDRV------------ ------------------------------------------------------------ ---LKE--LFGHLSKLLGCKQKIIDLL------------PKVE---MALSNIRE------ ----------------------ADNTVMFM-QGKRQKEIWHLLK--------IAC-TQSS ARSLVGSSL--EG----------------------------------------------- ------------------------------------------------------------ ----AVTPQASAWLPPT-SA--EREHPLSCVVT----PQDG--ETLAQMIEENLNCLGHL GTIIREANEE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QGS----RMMNL-DWSWLTE-------------------- >G_aculeatus_ENSGACP00000008884 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------ME------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------R-----------TPL-------------RHNQM--CGSWEMKERLGTGG FGHVYLYQHL--ESGEKIAVKLC-----RL-ELNS-KNK-----DRWGREIQIM-KKLNH GNVVQAR----EIP-----EELHSI-ALN-DLPLLAMEYCSRGDLRK--VLNKPENCCGL KESEVLSLLSDIDAGSGIQYLHEN-KII--HRDLKPENIVLQEI-GGKLIHKIIDLGYAK DLDQG----SLCT-SFVGTLQYL-----------------------APELFE-------- SKP---Y-TVTVDYWSFGTVIFECTCGFRPFLHHMQ--P---VQWTS---KVK----NKG PKDIV--AVEDMNGEVRFSTHLPYPNNV----SRPLLEPVESLLQMLLLWDAAARGG--- --------------GLDPDTNKP----HCYTALQNILSLKVI--------HVLDMTSAQL HSLILGAEES--LHSLQLRLETHTQTHVSPLSQ-------ELLLETGIS---LDPRRPPA HCLPEGL-----RGWDS----------SLVFLFD---KSLTKYSGPLTAR---------- PLPDSVNFIVRE------------------------------------------------ ------------TK-TQLPLSALRKVWGEAVSYICGLKEDYIRLYQ-------------- GQRAAMLSLL-------------RYNTNLTRYKNLLFSQSQ---QLRAKLAI--FKTSIQ NDLEQYTRQRHVGISSEKMLRTWQENEEKA----------------DG-FSK----VAEV GYLDEEIV--A--------LHSEIVELQRSP----FAR---RQG-DVMEQLEEKAIE-LY ------------KQLKG----PDPPHGYSDSSDMVRMILQTVQNQDRV------------ ------------------------------------------------------------ ---LKD--LYTHLSTILVCKQRIVDLF------------PKLE---RAVENIKT------ ----------------------AEAAVMQM-QMKRQKEFWYLLK--------IAC-NNTP TQSLMQQPT--YC----------------------------------------------- ------------------------------------------------------------ ----AYSRPEIVW-RLNTYA--NTKRPYTVHTG----ACGI--ETVSQLLDENQRYLSQL TSLVQDATQE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------MEH----SIMDQ-DWGWTKYGAAKAKPNNL---------- >T_rubripes_ENSTRUP00000036336 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------ME------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------R-----------FAL-------------KQSQL--CGSWEMKERLGMGG FGHVYLYQHLDQESGEKMAVKLC-----RL-ELNS-KNK-----ERWSREIQIM-KKLKH GNVVQAR----EVP-----EELTSI-SLN-DLPLLAMEYCSRGDLRK--LLNKPENCCGL KESEVFSLLSDI--GSGVQYLHDN-KII--HRDIKPENIVLQEV-DGKLVHKLIDLGYAK DLDQG----SLCT-SFVGTIQYL-----------------------APELFE-------- NKP---Y-TVTVDYWSFGTVIFECICGFRPFLHHMQ--P---VQWTS---KVK----NKG PKDIM--ATEDMNGEVRFSAHLHYPNNL----SRPLLEPVESLLQMLLLWDPAARGG--- --------------TVDADTNKP----YCNTALQNILNLKVI--------HVLDMTSAQL HSLILGAEEN--LQSLHLRLEAQTQSHIPPLSQ-------ELLLETGVS---LDPRRPPS QCLPDGL-----QGCDS----------CIVFLFD---KSLNKYSGPLTAR---------- PLPDSVNFIVRE------------------------------------------------ ------------TK-TQLPLTALRKVWGEAVSYICGLKEDYIRLYR-------------- GQRAAILSLL-------------RYNTNLTRYKNLLFSHSQ---QLQAKLAF--FKTSIQ QDLEQYSKQRQTGISSEKLLKTWQENQEKA----------------DE-FMK-VGLVADV AHLDEEIV--A--------VHFEIVELQRSP----FAR---RQV-DVMEQLEEKAIE-LY ------------KQLKAKC--PDPPHGYSDSSDMLKVILQMVQNQDRV------------ ------------------------------------------------------------ ---VKD--LYTHLSTILVCKRRIVDLF------------PKLE---TAVTDIKN------ ----------------------AEAGVVQM-QMKRQKEFWFLLK--------IAC-TVKM TRALVKRVA--NT----------------------------------------------- ------------------------------------------------------------ ----A---TICVF-RLIPVL--RHSHSHNNHVT----G-----ESVHQLLEENENYLSQL TSLLQETTRD-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------PEY----SIMEQ-DWSWTQC-------------------- >O_anatinus_ENSOANP00000003934 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------Q--DLGDKIAIKAC-----RQ-ELSA-KNK-----DRWCHEIQIM-KKLQS DSLVKACIRTSNIS-----EEQFSI--VSFKHPQLSREYCSGGLIERLILLNKTENCCGL KESQILSLLSDI--GSGIQYLHEN-RII--HRDLKPENIVLQNV-DGKVIHKIIDLGYAK DLDQG----SLCT-SFVGTLQYL-----------------------APELFE-------- NKP---Y-TATVDYWSFGTMVFEGIVGYRPFLHHLQ--P---FMWHE---KIK----KKD PKHIF--ASEEMSGEVRFSSHLPQPNSL----CRLIVEPMENWLQLMLNWDPQQRGG--- --------------GIDSSTKQP----RCFLLMDQILHLKIV--------HILNMTSAKI ISFLLLPDES--LHSLQSRIEQETGIST--GTQ-------ELLLEMGIS---LDPRKPAS QCVIDGV-----RGWDS----------YMVYLFD---KSKIVYEGPFASR---------- SLSDCVNYIVQD------------------------------------------------ ------------SK-IQLPITQLRKVWAEAVHYVSGLKEDYSRLFQ-------------- GQRAAMLSLL-------------RYNANLTKMKNTMISASQ---QLKAKLQF--FHQSIQ LDLDKYSDQMAYGISSEKMLKAWKEMEEKA----------------IH-CAQ----AGDI GYLDEQIM--T--------LHTEIVELQRSP----YAR---RQG-DVMETLEQKAID-LY ------------KQLKHR----SPDHSYSDSTEMVKIIVQTVQSQDRV------------ ------------------------------------------------------------ ---LKE--LFGHLSKLLGCKQKIIDLL------------PKVE---VALNNIKE------ ----------------------ADNTVMLM-QGKRQREIWHLLK--------IAC-TQSS ARSLVGSSL--EG----------------------------------------------- ------------------------------------------------------------ ----AVPPPTPAWLPAS-AT-ETVPHPFSSLVT----PKDG--ENFTQMIEENLNYLGCF STIIREAKEE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QGN----SMMSL-DWSWLNQ-------------------- >O_latipes_ENSORLP00000011761 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------ME------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------R-----------SAL-------------KQGQL--FGSWETKERLGMGG FGHVYLYQHV--ETGVKIAVKHC-----RL-DLSA-KNK-----ERWSREIQIM-SKLNH LNVVQAR----EVP-----EELHAI-ALN-DLPLLAMEYCSRGDLRK--VLHKPENCCGL KESEVLSLLKDI--GSGIQYLHEN-KII--HRDLKPENIVLQEI-DGKLVHKIIDLGYAK DLDQG----SLCT-SFVGTLQYL-----------------------APELFE-------- SKP---Y-TVSVDYWSLGTVLFECICGFRPFLHHMQ--P---VQWTS---KVK----NKG PKDIM--AVEDMNGEVRFSAHLPYPNNL----SSPLLEPIESLLQMLLLWDPSTRGG--- --------------GLDPETNKP----YFYSVLHNILSMKVI--------HVLDMTSAQL HSLDLGTDES--LLSLQLRLEAQTQAHISPQSQ-------ELLLETGNS---LDPRRPPI QFLPEGL-----RGWDN----------SIVFLFH---TSLNKYSGPLTAR---------- PLPESVNFIVRE------------------------------------------------ ------------TK-TQLPLSTLRKVWAEAVSYVCGLKEDYFRLYQ-------------- GQRTAMLSLL-------------RYNTTLTKYKNELFSESH---KLQAKLAF--FKTSIQ YDLEQYANQMKNGISSEKMWKTWQESREKV----------------DLLTKK----AADV GFLDKEIL--G--------LHNEIVELQRSP----YAR---RQG-DVMEQLEKKAIE-LY ------------RQLKAKCKSPDPPHGYSDSSDMVKTILQTVQNQDRV------------ ------------------------------------------------------------ ---LKD--LYTHLSTILVCKQHIVDLF------------PHLE---KALGDIKA------ ----------------------TENTVIQM-QKRRQKEFWYLLK--------VAC-VSNT ICGCVFRN---------------------------------------------------- ------------------------------------------------------------ ----RTTLQCRHNIPLIGKI--SSKR-----------------ETVGQLLNENQRYLSHL TSLMQDAAQS-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------MEH----SVMDQ-DWSWTQSGAVKVQSQKP---------- >T_nigroviridis_ENSTNIP00000019642 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------ME------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------R-----------FAL-------------KQSQL--CGSWEMKERLGMGG FGHVYLYQHL--ESGEKMAVKLC-----RL-ELNS-KNR-----ERWSREIQIM-KKLKH TNVVQAR----EVP-----EELTSI-SIN-DLPLLAMEYCSRGDLRK--ILNKPENCCGL KESEVLSLLSDI--GSGVQYLHDN-KII--HRDIKPENIVLQEN-DGKLVHKLIDLGYAK DLDQG----SLCT-SFVGTLQYL-----------------------APELFE-------- NKP---Y-TVTVDYWSFGTVIFECICGFRPFLHHMQ--P---VQWTS---KVK----NKG PKDIM--ATEDMNGDVRFSAHLHYPNNL----SRPLLEPLESLLQMLLLWDPVARGG--- --------------MLDTDTNKP----HCNTALQNILNMKVI--------HVLDMTSAQL HSLVLGAEEN--LQKKRWSL----------LFS-------PLL----------------- -----TL-----RGCDS----------STVFLFD---KSLNKYSGPLTAR---------- PLPDSVNFIVRE------------------------------------------------ ------------TK-TQLPLTALRKVWGEAVSYICGLKEDYIRLYS-------------- GQRAAILSLL-------------RYNTNLTRYKNLLFSCSQ---QLRAKLAF--FKTSIQ QDLEQYSKQSQSGISSEKLLRTWQENQEKV----------------DE-FMK----VADV VHLDEEIV--A--------VHFEIVELQRSP----FAR---KQV-DVMEQLEEKAIE-LY ------------KQLKG----PDPPHGYSDSSDMLKIILQMVQNQDRV------------ ------------------------------------------------------------ ---VKD--LYTHLSTILVCKRRIVDLF------------PKLE---TAVTDIKS------ ----------------------AETGVMQM-QMKRQKEFWFLLK--------IAC-VSTQ KCLVGNAVS--HT----------------------------------------------- ------------------------------------------------------------ ----P---NI---------------HSDGSEMTFFFFS-----MSVHQLLEENENYLSQL TSMLQETTKE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------TEH----TVVEQ-DWSWTQY-------------------- >T_guttata_ENSTGUP00000005662 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------R-----------PPA-------------LQALT--CGPWEMRERLGTGG FGNVIRWHNK--ETGEQVAIKQC-----RQ-ELSP-RNR-----DRWALEIQIM-KRLNH PNVVAAR----DVP-----EGMQKL-APN-DLPLLAMEYCQGGDLRK--YLNQLENCCGL REEAILILLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-EQRLIHKIIDLGYAK ELDQG----SLCT-SFVGTLQYL-----------------------APELLE-------- QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHT---KVR----QKS ELDIV--VSEDLSGEVKFSSCLPCPNNL----NSVLSGRLEKWLQLMLMWHPRQRG---- ---------------TDPTYGPN----GCFKALDDILNLKV------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >G_gorilla_ENSGGOP00000008804 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------ME------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------R-----------PPG-------------LRPGA--GGPWEMRERLGTGG FGNVCLYQHR--ELDLKIAIKSC-----RL-ELST-KNR-----ERWCHEIQIM-KKLNH ANVVKAC----DVP-----EELNIL--IH-DVPLLAMEYCSGGDLRK--LLNKPENCCGL KESQILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV-GGKIIHKIIDLGYAK DVDQG----SLCT-SFVGTLQYL-----------------------APELFE-------- NKP---Y-TATVDYWSFGTMVFECIAGYRPFLHHLQ--P---FTWHE---KIK----KKD PKCIF--ACEEMSGEVRFSSHLPQPNSL----CXXXXXXXXXXXXXXXXXXXXXXXX--- --------------XXXXXXXXX----XXXXXXXXXXXXXIV--------HILNMTSAKI ISFLLPPDES--LHSLQSRIERETGINT--GSQ-------ELLSETGIS---LDPRKPAS QCVLDGV-----XXXXX----------XXXXXXX---XXXXXXXXXXXXX---------- XXXXXXXXXXXX------------------------------------------------ ------------XX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-------------- XXXXXXXXXX-------------XXXXXXXXXXXXXXXXXX---XXXXXXXX--XXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----------------XX-XXX----XXXX XXXXXXXX--X--------XXXXXXXXXXXX----XGR---RQG-DLMESLEQRAID-LY ------------KQLKHR----PSDHSYSDSTEMVKIIVHTVQSQDRV------------ ------------------------------------------------------------ ---LKE--LFGHLSKLLGCKQKIIDLL------------PKVE---VALSNIKE------ ----------------------ADNTVMFM-QGKRQKEIWHLLK--------IAC-XXXX XXXXXXXXX--XX----------------------------------------------- ------------------------------------------------------------ ----XXXXXXXXXXXXX-XX--XXXXXXXXXXX----XXXX--ETSAQMIEENLNCLGHL STIIHEANEE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QGS----SMM------------------------------ >T_guttata_ENSTGUP00000016868 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------VLFLQIV--------HILNMTSAKI VSFLLHPEES--LHSLQNRIEFETGIST--GNQ-------EMLLETGIC---LDPRKPAS QCVIDGV-----RGWDS----------YMVYLFD---KSKTVYDGPFASR---------- SLSDCVNYIVQD------------------------------------------------ ------------SK-IQLPIPQLRKVWAEAVHYVIGLKEDYSRLFQ-------------- GQRAAMLSLL-------------RYNANVIKMKNNMVSASQ---QLKAKLEF--FHQSIR LDLERYSDQMAYGISSEKMLKAWKEMEEKA----------------SQ-CAQ----AEDI GYLDEQIM--A--------LHTEIVELQKSP----YAR---RQG-EVMESLEQRAID-LY ------------KQLKAR----PPDHAYSDSTDMVKIIVQTVQSQDRV------------ ------------------------------------------------------------ ---LKE--LFGHLSKLLGCKQKIIDLL------------PEIE---VALNNIKE------ ----------------------ADNSVMQM-QGKRQREIWHLLK--------IAC-TQSS SRSLVSSSL--EG----------------------------------------------- ------------------------------------------------------------ ----TASSPAATWLPQS-SSGNAAPHPLSSLAA----PEDG--ENFADMIQENVNYLELF SSILQEVRQE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QNS----MMVS----------------------------- >O_cuniculus_ENSOCUP00000011297 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ELDLKIAIKSC-----RL-ELSS-KNR-----ERWCHEIQIM-KKLNH ANVVKAC----DVP-----EELNFL--IN-DVPLLAMEYCSGGDLRK--LLNKPENCCGL KESQILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV-GGKXXXXXXXXXXXX XXXXX----XXXX-XXXXXXXXX-----------------------XXXXXX-------- XXX---X-XXXXXXXXXXXXXXXXXXXXXXXXXXXX--X---XXXHE---KIK----KKD PKCIF--ACEEMTGEVRFSSHLPQPNSL----CSLIVEPMENWLQLMLNWDPQQRGG--- --------------PVDLTLKQP----KCFILMDHILNLKXX--------XXXXXXXXXX XXXXXXXXXX--XXXXXXXXXXXXXXXX--XXX-------XXXXXXXXX---XXXXXXXX XXXXXXX-----RGCDS----------YMVYLFD---KSKTVYEGPFASR---------- SLSDCVNYISED------------------------------------------------ -------------------------------HYVWGLKEDYRKLFL-------------- GLRAAMLSLL-------------RYNANLTKMKNTLISASQ---QLKAKLEF--FHKSIQ LDLERYSEQMTYGIXXXXXXXXXXXXXXXX----------------XX-XXX----XXXX XXXXXXXX--X--------XXXXXXXXXXXX----XXX---XXX-XXXXXXXXXXXX-XX ------------XXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXXX------------ ------------------------------------------------------------ ---XXX--XXXXXXXXXXXXXXXXXXX------------XXXX---XXXXXXXX------ ----------------------XXXXXXXX-XXXXXXXXXXXXX--------XXX-TQSS ARSLVGSSL--EG----------------------------------------------- ------------------------------------------------------------ ----TVTPQASAWLPPT-SA--QREHPLSCVVT----PQDG--DTFAQMIEENLNCLGHL STIIREANEE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QGN----SMMNL-DWSWLTG-------------------- >A_aegypti_AAEL003245-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MM------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------A------------QS-------------EDPPF--IGDWHREKRLGSGG FGFVTLWKNH--KTNEMVAIKKCHILLDKS-EMTD-KNC-----ERWCNEVSLMMNKVRN ENIVRTV----RVQPETFLQELIKH-STN-KLPILCMEYCEGGDLRR--VLNRVSSCSGL KELEVREILRSL--RNAISYLHNL-RIT--HRDIKPENIVLKQM-GDRMVYKLTDLGYAK ALDKQ----SLNA-SLVGTVEYI-----------------------APDLIY-------- CDR---Y-NCSVDYWSMGIIAFEIICGIRPFSPHSI--V---AKWMM---LVQ----QKK SSHIA--ITEDNRENYTYHSELFSENHI----SSVLKTYLEKWLTLALEWNPKQRGHV-F QIGDKEVTEQQLKSAKEPSNGQPVQVLKIFSMLDSILSKKIL--------TMFCLYDFRF LSIEIDETTD--LKTLCSAITSQTGIVR--EAI-------EFVLPLDQK---LDRVTATT ------------KPIDL----------YLDGFHD----KPMLFIIKQG---AIIQADLKP QIPKSVTDVFQN------------------------------------------------ ------------IK-VKLKPHMLRQFVSNAWYFVTNEQRIYGTALD-------------- GIKNYGLML----------------NDQIVKGRDDVSKLNKVSYGISGGLEY--HKLSLI QAKEMAKVNQ---LPPGTIQQCFSVLEERC----------------TRMEAT----IGKL AEVADKIT--T--------RYESVLKRSREA----VAHQLLRGY-DQHDPFNLKSLDNRY ------------EIARVQ--ILEKNTHEKSHIDMLQAVYECLKKRDIL------------ ------------------------------------------------------------ ---LRDYSFKELQQQLIDIRREMQEIR------------KALD---KAQEHAEK------ ----------------------FKKDLAKM-IVEHNNSVWSLLN--------QGS-TSN- -TSNPAVSTYNGN----------------------------------------------- ------------------------------------------------------------ ----AAIIPDIDRIMGSSSG-----------------------TANGDLPGAPKFVVGGT VTTLQNSLGG-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------EPISKSLLCYGEGPDVESLLTANQSLIMTYGSRIDSAKDVE >A_gambiae_AGAP009166-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MI------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------K------------PF-------------EDPPQ--IGEWCREKRLGNGG FGVVTLWRNK--QTQQAVAIKKFHILQDRS-EITD-KHC-----ERWRNEVKLMTETVQN DHIVRTV----DVQPRAFIEELLRS-SAN-GLPVLCMEYCEGGDLRR--VLNRVENCSGL REQDVRDVLRSL--RSAIAYLHSL-KIT--HRDIKPENLVLKQH-GDRFIYKLTDLGYAK ALDKQ----SLNA-SLVGTVEYI-----------------------APDLIY-------- CDR---Y-NCSVDYWSMGVIGFEIVTGVRPFIPHAP--I---TRWMM---HVQ----QKK SADIA--ITEDNRENYTYHTEIFAENHI----STCLRKQLERWLMLALEWNPKQRGYVPY SATVAEGTPPKSVTFAEDSRPGGSTVLKIFSLLDQILEKRIL--------VLFSLHDCRW IDLEVTPDTS--MAAVREHVYQLTGIPV--DEI-------EFILPLEQK---QPRVGSDT ------------RPYDL----------YLPELQS---GKPMVYVAHRASRESIVQRDLKP RIPKSITDVFQN------------------------------------------------ ------------IK-VKLKPHMLRQFIANAYYFIANEQRLYVLLLD-------------- GVRNYGLTL----------------NDAIARRKEEIGRMNKVVYGIVGGVEY--HKLTVS HTRDALNAGKR--IPSASFETASHQWEEKC----------------SRVETN----VRKL AEMADKIS--K--------RYESVLKRSRDA----LRHALLQEY-EQQDYFGLKTVEGRY ------------EQTRAR--ILEKITNEKSHMDMSQAVYECLKRRDVL------------ ------------------------------------------------------------ ---LRDAGFLELQRQLLDVRHEMQEIE------------KVLE---KVVELTEK------ ----------------------YKRELARL-TLEHQDEVWKMLSS--VDANGQAV-TTNG TLSNGGGTPHGPC----------------------------------------------- ------------------------------------------------------------ ----IADIDDMVPVFASAKT-----------------------RSIASSNGTPKFLLGGP MTPLPSTVTN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSIEGHHR-EEEGPNVDELIAANETLIMT------------ >A_aegypti_AAEL010548-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------M------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------A------------QS-------------EDPPF--IGDWHREKRLGSGG FGFVTLWKNH--KTNEM-----CHILLDKS-EMTD-KNC-----ERWCNEVSLMMNKVRN ENIVRTV----RVQPETFLQELIKH-STN-KLPILCMEYCEGGDLRR--VLNRVSSCSGL KELEVREILRSL--RNAISYLHNL-RIT--HRDIKPENIVLKQM-GDRMVYKLTDLGYAK ALDKQ----SLNA-SLVGTVEYI-----------------------APDLIY-------- CDR---Y-NCSVDYWSMGIIAFEIICGIRPFSPHSI--V---AKWMM---LVQ----QKK SNHIA--SLKITGR--IYHSELFPENHI----SSVLKTYLEKWLTLALEWNPKQRGH--- -----------------PSNGQPVQVLKIFSMLDSILSKKIL--------TMFCLYDFRF LSIEIDETTD--LETLCSAITSQTGI---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >D_melanogaster_FBpp0082690 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MI------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TVVFCFSDCHGGIQILGRMSSVNKIKLNENNKMHSFGNWERCRNLGEGG FGLVIHWRNR--TTGREIATKHI-----KE-MGALSADQQVKLSERWNKELNWSRQFKNF PHIVAGV----DIEDPDFLEYLNGMFSA--KLPVIVLEYCNGGDVRK--RLQSPENANGL TEFEVRQILGAL--RKALHFLHSQCGIC--HRDLKPDNIVIQRGVDGKKIYKLTDFGLAR GTPDQ----TMVQ-SVVGTRHYY-----------------------APEVVE-------- NGF---Y-NSTVDLWSFGVIAYELVTGELPFIPHQT-----LKNIIL---NLI----KKP AKCIAITEDPEDNTRFVNQFELPQTHHL----SRPWAAQFTKWLASPLNSNYKERGQ--- --------------------LAANNVPVVFADLDKILNMNVL--------TIFAVNNCER LEYAVSAEMT--MKDLIALIVLDTGMDE--KEL-------YFVLPTSHPHKTITPKSTPL QLYVEEWSDTSKDSRKWTKRSN-----PPVMLYIFQVKKECDY----------------- KIPEPILSILSRKF---------------------------------------------- ----------IANKFKTKERWLQKRVVLDMLYVLTKEQARYEMLVS-------------- GINERALSLEDEMMENSFIDSIDKQRIIISFAYDQLTSLLK---EAQAKIPS--RQLISS AQWEKLNRNYNFIIQSAKSIRSFLEACLRE--------------------------AKDM VKTTNQLRKEV--------CEKDLFDCARFY----------------------------- ------------KKYLCNGAIISPSELNNDAEEFAKSRFKLYNEGEAR------------ ------------------------------------------------------------ ----------------------------------------------HLPKSIDH------ ---------------------------MHYLYFKTKESIPVLLQQ--FCDIKKEIFQINL QMLMSASSTPPPK----------------------------------------------- ------------------------------------------------------------ ----LELSAAMDRLAISSGSPSSDPFDSLRTINAIEEAERINNILVNEMKIDHY------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >T_rubripes_ENSTRUP00000005087 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MASTP--NYLWSLQDVLGQGA TASVYKARNK--KSGELVAVKVF-----NT-MSYN-RPH-----DVQMREFEML-RKLNH SNIVRLY----AVE-----ELPS-------KQKILVMEYCSGGSLLT--VLEEPENAFGL PETEFLTVLQCV--VRGMNHLREN-GVV--HRDIKPGNIMRQAGEDGKSVYKLTDFGAAR ELEDD----EKFI-SIYGTEEYL-----------------------HPDMYERAVLRKPH QKS---Y-GVSVDLWSIGVTFYHAATGSLPFIPYGG--PRKNKLTMF---KIT----TEK PTGAISGLQRVADGSIEWSYSLPHSCQL----SQGLKVLLVPVLAGIMEADQEKCWG--- ---------------FD----------QFFTATTDILKRQPV--------HLFSLQQAMA HCIYIHHYDT--VATFFEEVASQTGIGV--EQQ-------HLLYLGHALP--LEGSMKAV NLPHTS---PT----------------QPLTLLS--YGFEPNPSLPFRE-P------ETP VIPPKFDVLADYNF---------------------------------------------- ------------TK-------VIVGAVHQYLMVTQLLRTHRELLLQ-------------- GFYSYMMKL-----------------------QKECGEVMHSIAMITIRLQS--CLNLDH RIH---------------TLFRGHYASGNQ----SPADNSQKLK--SVHEHL-PIYAACI QEFQSRLD--H--------LQIEQAKLAEVL-------ASDKSC-QKMQVLLQKITA-IH ------------QHYRKD---RLNGKLAYNDEQIHKFEKIHLSNHIKR------------ ------------------------------------------------------------ ---VKSLFREDSVLRYKELLASTQIWSRSEPVPSLTPGTCSLV---GCKSKFKN------ ---------------------------ADP-AAGVQLFLHRLVG---------------R LGDEILYSLQSNQ----------------------------------------------- ------------------------------------------------------------ ----------------------------------EPQQPGLEPTDKQHMVLRMHHLKEEM EILVRELKCN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NSIIERHRLMTCPPHL------------------------- >D_rerio_ENSDARP00000014302 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MTSTA--NYLWSQEDILGQGA TANVYKARNK--KTGELVAVKVF-----NL-VSYN-RPY-----EVQMREFEVL-QLLNH VNIVKLF----AVE-----EIISNP-----KQKILVMEYCSGGSLLN--MLEQPEHAFGL PESEFLIVLHCV--AHGMNHLREN-SVV--HRDIKPGNIMRQVGEDGRSVYKLADFGAAR ELEDD----EKFV-SIYGTEEYL-----------------------HPHMYERAVLRIPQ QKA---Y-GVSVDLWSIGVTIYHMATGSLPFRPFGG--PRKNKQMMH---KIT----TEK PAGTIAGVQKEEDGPIEWRDKLPLSCQL----SEGLKTQLVPVLANILLADDEKCWK--- ---------------FP----------QFFSATNDILNRITI--------YIFSLQQATT YSIYIQFHNT--VSIFFEDVQAQTGIEP--AAQ-------QYLFQGHPLI--LDPSMKVV NIPHTS---SD----------------KPMILIS--RRLERIIGYPFEE-P------ESP PMPGKFDVVADFVF---------------------------------------------- ------------TK-------TIVKVIHQYLRIAYSLQEYRQFILQ-------------- GFNSYIEQT-----------------------SSEVIDVTHRISKVKMKLH---SSISTE KTL---------------HVFTQTFAHEFP----DFIDSKKKFP--LIEAELQQMCGRGI REFQNILQ--Y--------LRVTLSKHSETL-------ANDKSI-QKMEVLLSQIVD-VH ------------FQYFRD---RQTRKLGYNDEQIHKFEKLNLSSYLKK------------ ------------------------------------------------------------ ---FKSLFKDDCFQKYLDVLNTTDRCS------------RALY---DMQTHLDK------ ----------------------FRDTLLQR-IQDLKAHEILQNK---------------V L-ERVVHRAVQQP----------------------------------------------- ------------------------------------------------------------ ----------------------------------VKAEVVDGKKKEEHMILKMTRLKSEM EAVAWELQKN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NNMIESLSVVTPTMPVEKKNPQTNRP--------------- >D_rerio_ENSDARP00000074566 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MTSTA--NYLWSQEDILGQGA TANVYKARNK--KTGELVAVKVF-----NL-VSYN-RPY-----EVQMREFEVL-QLLNH VNIVKLF----AVE-----EIISNP-----KQKILVMEYCSGGSLLN--MLEQPEHAFGL PESEFLIVLHCV--AHGMNHLREN-SVV--HRDIKPGNIMRQVGEDGRSVYKLADFGAAR ELEDD----EKFV-SIYGTEEYL-----------------------HPHMYERAVLRSPQ QKA---Y-GVSVDLWSIGVTIYHMATGSLPFRPFGG--PRKNKQMMH---KIT----TEK PAGTIAGVQKEEDGPIEWRDKLPLSCQL----SEGLKTQLVPVLANILLADDEKCWK--- ---------------FP----------QFFSATNDILNRITI--------YIFSLQQATT YSIYIQFHNT--VSIFFEDVQAQTGIEP--AAQ-------QYLFQGHPLI--LDPSMKVV NIPHTS---SD----------------KPMILIS--RRLERIIGYPFEE-P------ESP PMPGKFDVVADFVF---------------------------------------------- ------------TK-------TIVKVIHQYLRIAYSLQEYRQFILQ-------------- GFNSYIEQT-----------------------SSEVIDVTHRISKVKMKLH---SSISTE KTL---------------HVFTQTFAHEFP----DFIDSKKKFP--LIEAELQQMCGRGI REFQNILQ--Y--------LRVTLSKHSETL-------ANDKSI-QKMEVLLSQIVD-VH ------------FQYFRD---RQTRKLGYNDEQIHKFEKLNLSSYLKK------------ ------------------------------------------------------------ ---FKSLFKDDCFQKYLDVLNTTDTCS------------RALY---DMQTHLDK------ ----------------------FRDTLLQR-IQDLKAHEILQNK---------------V L-ERVVHRAVQQP----------------------------------------------- ------------------------------------------------------------ ----------------------------------VKAEVVDGKKKEEHMILKMTRLKSEM EAVAWELQKN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NNMIESLSVVTPTMPVEKKNPQTNRP--------------- >T_nigroviridis_ENSTNIP00000010090 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MVASTP--NYLWSLQDVLGQGA TANVYKARNK--KSGELVAVKVF-----NT-VSYN-RPH-----DVQMREFEML-RKLNH SNIVRLY----AVE-----ELPS-------KQKVLVMEYCSGGSLLM--LLEEPENAFGL PETEFLTVLQCV--VRGMNHLREN-GVV--HRDIKPGNIMRQTGEDGKSVYKLTDFGAAR ELEDD----EKFI-SIYGTEEYL-----------------------HPDMYKCAVLRKPH QKS---Y-GVSVDLWSIGVTFYHAATGSLPFVPFGG--PRKNKLTMF---KIT----TEK PTGAISGTQHVVDGSIEWGYNLPHSCQL----SQGLKAQLVPVLAGIMEADQEKCWG--- ---------------FD----------QFFTATTDILQRQPV--------HLFSLQQAMA HCIYIHHYDT--VATFFEEVASQTGIAA--EQQ-------HLLYLGHELL--LEGSMKVV TLPHTS---PA----------------QPLLLLS--YSFEANHSLPFRELA------DTP VIPPKFDVLADYNF---------------------------------------------- ------------TK-------VMVGAVHQYLMSTQVLRSHRELLLQ-------------- GFYSYMMKL-----------------------RTECGEAMHSIAMVTIRLQS--CLSLEH RIR---------------LL--SHCPSGDQ----SPSESSQTLK--AVHEHL-PIYASCI QEFQSRLE--H--------LQIEQAKLAEAL-------ASDKSC-QRMQVLLQKITA-IH ------------QHYRKD---RLNGKLAYNDEQIHKFEKIHLSTHIKR------------ ------------------------------------------------------------ ---VKSLFREECVHRYKELLAT-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >B_taurus_ENSBTAP00000046540 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTV--NYLWHTDDLLGQGA TASVYKARNK--KSGELVAVKVF-----NT-ASYL-RPR-----EVQVREFEVL-RKLNH QNIIKLF----AVE-----ETGAG------RQKVLVMEYCSSGSLLS--VLESPENAFGL PEDEFLVVLRCV--AAGMNHLREN-GIV--HRDIKPGNIMRLLGEEGQSIYKLTDFGAAR ELDDD----EKFV-SVYGTEEYL-----------------------HPDMYERAVLRKPQ QKA---F-GVTVDLWSIGVTLYHAATGSLPFVPFGG--PRRNKEIMY---RIT----TEK PAGAIAGTQRRENGPLEWSYTLPITCQL----SMGLQSQLVPILANILEVEQAKCWG--- ---------------FD----------QFFAETSDILQRGVI--------HVFSLPQAVL HR-YVHAHNT--IAIFLEAVYEQTGVAP--QHQ-------EYLFEGHLCV--LEPGLSAQ HIAHTT---AS----------------SPLTLFS--TASEPPKGLAFRD-P----ALDVP KFVPKVDLQADYST---------------------------------------------- ------------AK-------GILGAGYQACGWHR-LCCGAGADGS-------------- GLHWFVEML-----------------------QATCRRTLELARMALLFLS---SSLGPE RFS---------------GLAGVPELQDLK----RTAELRSRLR--NLAEVL-SRCSHNI TETQKTLS--D--------LCSELVKNRDQV------HED-RSI-QQIQCCLDKMYL-TY ------------KQFKKS---RMRPGLGYNEEQIHKLDKAPAEREAVL------------ ------------------------------------------------------------ ---EEQKPQQSCVQKPPLWGLRWGHVA------------WLVD---ETRSHLRL------ ----------------------VGCSVAAC-NTEAQGAQESLSK---------------I L-DRLSHQLLQER----------------------------------------------- ------------------------------------------------------------ ----T--QGAQASPPL------------------TAPYPSSVL---KDLVLHMQELHGEM KVLASDLQDN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRIIEGLSRIPLAPDI------------------------- >P_pygmaeus_ENSPPYP00000000308 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTA--NYLWHTDDLLGQGA TASVYKARNK--KSGELVAVKVF-----NT-TSYL-RPR-----EVQVREFEVL-RKLNH QNIVKLF----AVE-----ETGGS------RQKVLVMEYCSSGSLLS--VLESPENAFGL PEDEFLVVLRCV--VAGMNHLREN-GIV--HRDIKPGNIMRLVGEEGQSIYKLTDFGAAR ELDDD----EKFV-SVYGTEEYL-----------------------HPDMYERAVLRKPQ QKA---F-GVTVDLWSIGVTLYHAATGSLPFIPFGG--PRRNKEIMH---RIT----TEK PAGAIAGAQRRENGPLEWSYTLPITCQL----SLGLQSQLVPILANILEVEQAKCWG--- ---------------FD----------QFFAETSDILQRVVV--------HVFSLSQAVL HHIYIHAHNT--IAIFQEAVHKQTSVAP--RHQ-------EYLFEGHLCV--LEPSVSAQ HIAHTT---AS----------------SPLTLFS--TA--IPKGLAFRD-P----ALDIP KFVPKVDLQADYNT---------------------------------------------- ------------AK-------GVLGAGYQALRLARALLDGQELMLR-------------- GLHWVMEVL-----------------------QATCRRTLEVARTSLLYLS---SSLGTE RFS---------------SVAGTPEIQELK----AAAELRSRLR--TLAEVL-SRCSQNI TETQESLS--S--------LSRELVKSRDQV------HED-RSI-QQIQCCLDKMNF-IY ------------KQFKKS---RMRPGLGYNEEQIHKLDKVNFSHLAKR------------ ------------------------------------------------------------ ---LLQVFQEECVQKYQASLVTHGKRM------------RVVH---ETRNHLRL------ ----------------------VGCSVAAC-NTEAQGVQESLSK---------------L L-EELSHQLLQDR----------------------------------------------- ------------------------------------------------------------ ----A--KGAQASPPP------------------IAPYPSPTR---KDLLLHMQELCEGM KLLASDLLDN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRIIERLNTVPAPPDV------------------------- >E_caballus_ENSECAP00000000587 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTV--NYLWHTDDLLGQGA TASVYKARNK--KSGELVAVKVF-----NT-ASYM-RPR-----EVQVREFEVL-RKLNH QNIVKLF----AVE-----ETGGS------RQKVLVMEYCSSGSLLS--VLESPENAFGL PEDEFLVVLRCV--VAGMNHLREN-GIV--HRDIKPGNIMRLLGEEGQSIYKLTDFGAAR ELDDD----EKFI-SVYGTEEYL-----------------------HPDMYERAVLRKPQ QKA---F-GVAVDLWSIGVTLYHAATGSLPFVPFGG--PRRNKEIMY---RIT----TEK PAGAIAGTQRRENGPLEWSYSLPITCRL----SSGLQSQLVPILANILEVEQAKCWG--- ---------------FD----------QFFAETSDILQRVIV--------HVFSLSEAVL HHVYIHGHNT--IAIFLEAVYEQTNVAP--QHQ-------EYLFEGHLCV--LEPNLSAQ HIAHTT---AS----------------SPLTLFS--MASETPKGLAFRD-P----ALDIP KFVPKVDLQADYNT---------------------------------------------- ------------AK-------GVLGAGYQALRLAQALLAGQELMLR-------------- GLHWFVEIL-----------------------QATCRRTLEVTRMALLFLS---SSLGTD RFS---------------NGAGTPEIQELK----RATELRSQLR--TLAGVL-SRCSHNI TETQMSLS--S--------LSSELVKNRDQV------HED-RST-QKIQCCLDKMYL-IY ------------KQFKKS---RVRPGLGYNEEQIHKLDKVNFSHLAKR------------ ------------------------------------------------------------ ---LLQVFQEECVQKYQTSLVTHGKHM------------RVVH---ETRNHLRL------ ----------------------VGCSVAAC-NTEAQGAQESLSK---------------L L-DRLSQQLLQDR----------------------------------------------- ------------------------------------------------------------ ----A--KGAQASPPP------------------TAPYPSPAL---KDLVLHMQELYEEM KLLAFDLQDN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRIIEGLSRVPSTPGV------------------------- >H_sapiens_ENSP00000356087 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTA--NYLWHTDDLLGQGA TASVYKARNK--KSGELVAVKVF-----NT-TSYL-RPR-----EVQVREFEVL-RKLNH QNIVKLF----AVE-----ETGGS------RQKVLVMEYCSSGSLLS--VLESPENAFGL PEDEFLVVLRCV--VAGMNHLREN-GIV--HRDIKPGNIMRLVGEEGQSIYKLTDFGAAR ELDDD----EKFV-SVYGTEEYL-----------------------HPDMYERAVLRKPQ QKA---F-GVTVDLWSIGVTLYHAATGSLPFIPFGG--PRRNKEIMY---RIT----TEK PAGAIAGAQRRENGPLEWSYTLPITCQL----SLGLQSQLVPILANILEVEQAKCWG--- ---------------FD----------QFFAETSDILQRVVV--------HVFSLSQAVL HHIYIHAHNT--IAIFQEAVHKQTSVAP--RHQ-------EYLFEGHLCV--LEPSVSAQ HIAHTT---AS----------------SPLTLFS--TA--IPKGLAFRD-P----ALDVP KFVPKVDLQADYNT---------------------------------------------- ------------AK-------GVLGAGYQALRLARALLDGQELMFR-------------- GLHWVMEVL-----------------------QATCRRTLEVARTSLLYLS---SSLGTE RFS---------------SVAGTPEIQELK----AAAELRSRLR--TLAEVL-SRCSQNI TETQESLS--S--------LNRELVKSRDQV------HED-RSI-QQIQCCLDKMNF-IY ------------KQFKKS---RMRPGLGYNEEQIHKLDKVNFSHLAKR------------ ------------------------------------------------------------ ---LLQVFQEECVQKYQASLVTHGKRM------------RVVH---ETRNHLRL------ ----------------------VGCSVAAC-NTEAQGVQESLSK---------------L L-EELSHQLLQDR----------------------------------------------- ------------------------------------------------------------ ----A--KGAQASPPP------------------IAPYPSPTR---KDLLLHMQELCEGM KLLASDLLDN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRIIERLNRVPAPPDV------------------------- >X_tropicalis_ENSXETP00000015947 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTA--NHLWLLSDILGQGA TANVYRGRNK--KTGDLYAVKVF-----NN-LSFL-RPA-----DVQMREFEVL-KKLNH KNIVKLF----AIE-----EEMSS------RHKVLVMEFCPCASLYS--VLEEPANAYGL PESEFLIVSRDV--VAGMNHLREN-GII--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR ELDDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKEH QKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----AGK PSGAISGVQRAENGPIEWSGELPVTCNL----SMGLQTLFTPVLANILEADQEKCWG--- ---------------FE----------QFFAVTNDVFNRIVI--------HVFSLQQMTP HKIYINTYDK--VPDFHDLVYKQTKIPA--QNQ-------ELLFEGRRLV--LEQGRLAQ HFPITT---EE----------------NPIFVLT--REMVSVIGLRFDE-I----VI--P KLHSHYDLDVDANM---------------------------------------------- ------------AK-------AVTGVACYYCRIAASLLLVLELMRK-------------- GIRWLSEIL-----------------------KEEYNENVHRNTEVSLKLSF--CNRTIE KDL------KT-YEQ---LIQTSVEP--------EVYVIHGKLL--NLSSTQ-ESLKSSL QEIKNKLTPGG--------VLMDSWINAEGT------HSADRNV-EKLQVLLSLITE-IY ------------CQFKKD---KAQRRLLYNEEQIHKFDKQKMCIHSTK------------ ------------------------------------------------------------ ---AYSLFKDECVGKYEGFRSKALDWM------------RKMI---HVRKQLFS------ ----------------------LKSQCFEI-EEEVSKCQHYINQ---------------Y Q-EKMSPKMFA-A----------------------------------------------- ------------------------------------------------------------ ----P--GGIKSAVNP------------------IYSSPNTLV----EMTLGMRKLKEDM EGVVKELEEN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NHILERFGALTIDGGFRNVD----CI--------------- >A_carolinensis_ENSACAP00000012863 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTL--NYLWKTDDVLGQGA TASVYKARNK--ISGELVAVKVF-----NS-VSYL-RPQ-----EVQIREFEVL-RKLNH QNIVKLF----SVE-----EIEIS------KQKVLVMEYCSGGSLLS--LLEEPENAFGL SESEFLIVLHCV--VSGMNHLREN-GIV--HRDIKPGNIMRLTSEDRQSIYKLSDFGAAR ELDDD----EKFE-SVYGTEEYL-----------------------HPDIYKRAVLKKPQ QKA---Y-GVTVDLWSIGVTFYHAATGSLPFIPFGG--PRRNKEIMY---KIT----TEK PTGAIAGVQEQENGAIIWTDELPISCQL----SLGLKRPLVPILANILEADQEECWS--- ---------------FD----------QFFAEANDILHRTII--------HVFSLSQAVM LHVYIHPYNT--AIKFLEEVFRQTSTAP--CHQ-------EYLFEGHSYE--LEPNLQVC HFPKTT---ET----------------CPFILMS--TDPEDPVGLRYRD-P----TLEFP RFLPKVDVIADCST---------------------------------------------- ------------AK-------GVLSATHQTLRISQSFLKDQELILR-------------- GLYWLRYVL----------------------------QVCNKISLIPVSFTFPDSLFTTS FVS---------------AFEKWLTVYSIN----GLLWTLSVLA--QISEEI-SRCSHSI SEQQAALQ--G--------ILSEVGKKQNQM-------KEDRSI-QKMEACLDKMQL-IY ------------AQFKKA---RKCPRLGYNEQQIHKLDKLNLGHSAKK------------ ------------------------------------------------------------ ---VILVFQDNSEHQYRAALSGHGTRM------------R-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >M_mulatta_ENSMMUP00000038190 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTA--NYLWHTDDLLGQGA TASVYKARNK--KSGELVAVKVF-----NT-TSYL-RPR-----EVQVREFEVL-RKLNH QNIIKLF----AVE-----ETGGS------RQKVLVMEYCSSGSLLS--VLESPENAFGL PEDEFLVVLRCV--VAGMNHLREN-GIV--HRDIKPGNIMRLVGEEGQSIYKLTDFGAAR ELDDD----EKFV-SVYGTEEYL-----------------------HPDMYERAVLRKPQ QKA---F-GVTVDLWSIGVTLYHAATGSLPFIPFGG--PRRNKEIMY---RIT----TEK PAGAIAGAQRRENGPLEWSYTLPITCQL----SLGLQSQLVPILANILEVEQAKCWG--- ---------------FD----------QFFAETSDILQRVVI--------HVFSLSQSVL HHVYIHAHNT--IAIFQEAVHKQTSVAP--RHQ-------EYLFEGHLCV--LEPSISAQ HIAHTT---AS----------------SPLTLFS--TA--IPKGLAFRD-P----ALDVP KFVPKVDLQADYNT---------------------------------------------- ------------AK-------GVLGAGYQALRLSRVLLDGQELMLR-------------- GLHWVMEVL-----------------------QATCRQTLEVARTSLLYLS---SSLGTE RWV---------------SVAGMPEIQELK----VAAELRSRLR--TLAEVL-SRCSQNI TETQESLS--S--------LSQELVKSRDQV------HED-RSI-QQIQCCLDKMNF-IY ------------KQFKKS---RMRPGLGYNEEQIHKLDKMNFSHLAKR------------ ------------------------------------------------------------ ---LLQVFQEECVQKYQASLVTHGKRM------------RVVH---ETRNHLRL------ ----------------------VSCSVAAC-NTEAQGVQESLSK---------------I L-EELSHQLLQDR----------------------------------------------- ------------------------------------------------------------ ----A--KGAQASPPP------------------IAPYPSPTP---KDLLLHMQELCEGM KLLASDLLDN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRIIERLNRVPAAPDV------------------------- >G_aculeatus_ENSGACP00000000783 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTT--NYLWLISDLLGQGA TANVYRGRHK--KTGDLYAVKVF-----NN-LSFL-RPL-----DVQMREFEVL-KKLNH KNIVKLF----AVE-----EESNT------RHKVLVMEYCPCGSLYT--VLEESSNAYGL PEDEFLLVLHDV--VAGMNHLREY-GIV--HRDIKPGNIMRVIGEDGRSVYKLTDFGAAR ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDH QKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TEK PSGTISGHQKCENGKIEWSTEMPVSCSL----SKGLQSLLTPVLANILEADQEKCWG--- ---------------FD----------QFFAETNDILHRTVV--------YVFSLQQATL HHIYIHEYNT--AALFQELLSRRTSIPL--HNQ-------ELLYEGRRLV--LDPNRQAK MFPKSS---RD----------------NPIMLVS--RESVATVGLIFED-P----SP--P KVQPRYDLDLDASY---------------------------------------------- ------------AK-------TFAGDVGHLWKTSESLLVYQELVRK-------------- GVRGLIELM-----------------------KEDYSEILHKKSEVFHLCNF--CTQILE KTE------QL-FEA---LMQANVMSSEYD----EICDMHKKVL--RISGSL-EPIERTT QDIKSKFTSGG--------LLTDGWTQQVGT------HPEDRNV-EKIKVLLDAITA-IY ------------QQFKKD---KAERRLPYNEEQIHKFDKQKLVLHATK------------ ------------------------------------------------------------ ---ARSLFTEECAMKYRLFISKSEEWL------------KKVH---HVKKQLLG------ ----------------------LSGQLISI-EKEVTMLMERAIK---------------L Q-EHLPQKVLPLV----------------------------------------------- ------------------------------------------------------------ ----S--SGMK---PQ------------------AYLSQNTLV----EMTLGMKKLKEEM DEVSKELAEN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NHFLERFGSLTLDGGLR------------------------ >C_familiaris_ENSCAFP00000035372 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTI--NYLWHTDDLLGQGA TASVYKARNK--KSGELVAVKVF-----NT-ASYL-RPR-----EVQVREFEVL-RKLNH QNIVKLF----AVE-----ETGGS------RQKVLVMEYCSSGSLLS--VLESPENAFGL PEDEFLVVLRCV--VAGMNHLREN-GIV--HRDIKPGNIMRLMGEEGQSIYKLTDFGAAR ELDDD----EKFV-SVYGTEEYL-----------------------HPDMYERAVLRKPQ QKT---F-GVTVDLWSIGVTLYHAATGSLPFVPFGG--PRRNKEMMY---RIT----TEK PAGAIAGTQRRENGPLEWSYGLPITCRL----SPGLQSQLVPILANILEVEQAKCWG--- ---------------FD----------QFFAETSDILQRVVV--------HVFSLSQAVL HHIYIHAHNT--IAIFLEAVYEQTSVAP--QHQ-------EYFFEGHLCV--LEPSLSAQ HITHTT---AS----------------SPLTLFS--KASETPKGLAFRD-P----AQDIS KFFPKVDLQADYTT---------------------------------------------- ------------AK-------SILGAGYQALWLARTLLAGQEMMLR-------------- GLHWFVETL-----------------------QATCRRTLEVTRMALLFLS---SSLGTE RFS---------------SVAGMPEMQELK----RVTELRSRLR--ALVEAL-SRCSHNI TETQVSLS--N--------LSSELVKNRDQV------HAD-RSVIQQIQCCLDKMNL-IY ------------KQFKKS---RMRPGLGYNEEQIHKLDKVNFSHLAKR------------ ------------------------------------------------------------ ---LLQVFQEKCVQKYQTSLVTHGKWM------------REVH---ETRNHLRM------ ----------------------VSCSVAAY-NTEAQGVQESLSK---------------I L-DWLSHQHLQDR----------------------------------------------- ------------------------------------------------------------ ----T--KEAQASPPP------------------TAPYPSPAL---TDLVLHMQELCEEM KLLAFDLQDN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRIIEGLSRPPSAPDS------------------------- >M_domestica_ENSMODP00000002458 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTA--NYLWHTDDLLGQGA TASVYRARNK--KSGELVAVKVF-----NN-ASYL-RPR-----EVQVREFEVL-RKLKH ENIVKLF----AVE-----ETGSN------KQKVLVMEYCSSGSLLS--VLESPENAFGL SEAEFLVVLRCV--VAGMNHLREN-GIV--HRDIKPGNIMRLLGEDGQSIYKLTDFGAAR ELEDD----EKFV-SVYGTEEYL-----------------------HPDVYERAVLRKPQ QKA---F-GVTVDLWSIGVTLYHAATGSLPFVPFGG--PRRNKEIMYARDQGG----KER LAAVCPGTQKRENGPLEWSYKLPITCRL----SLGLQAQLVPILASILEVDQEKCWG--- ---------------FD----------QFFAETSDILQRIVV--------HVFSLPQAVL HHVYVHAHNT--IGIFLEAVYKQTSVEP--SHQ-------EYLFEGHPCL--LEPSLPAQ FLAQTT---ED----------------SPLTLLN--EDSDNPTGLAFRN-P----SLDVP KFVPKVDLQADYNT---------------------------------------------- ------------AK-------GVLSMGHQVLRISRALQDGQEMMLR-------------- GLHWVVEVL-----------------------KATCGRTLETTRTALLFLS---PSLGTD GFA---------------SMTGESEVPELK----EAGELRSKLQ--TINEVL-SRCSQNI VETQTSLI--S--------LSSELVKTWDQV------HED-RST-QQIQCCLDKMNL-IY ------------KQFKKA---RMRPGLGYNEEQIHKLDKVNFGHLAKR------------ ------------------------------------------------------------ ---LLVLFQEDCVQKYQAALLTHGKRM------------RTVH---ETRKHLRL------ ----------------------VSSSVTAC-KAEAQEAQGQLSK--------KRISSSQA L-DRLSRRLWQGR----------------------------------------------- ------------------------------------------------------------ ----M--KAAQDSSLP------------------LAAYSRSMP---KDLVLHIQELREEM KLLAFDLQHN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NQIIERLSGVPAAPRS------------------------- >T_nigroviridis_ENSTNIP00000005945 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTT--NYLWLISDLLGQGA TANVYRGRHK--KTGDLYAVKVF-----NN-LSFL-RPL-----DVQMREFEVL-KKLNH KNIVKLF----AVE-----EESNT------RHKVLVMEYCPCGSLYT--VLEESSNAYGL PEDEFLIVLHDV--VAGMNHLREY-GIV--HRDIKPGNIMRVIGEDGRSVYKLTDFGAAR ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDH QKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TEK PPGTISGHQKCENGKIEWSSEMPVSCSL----SKGLQSLLTPVLANILEADQEKCWG--- ---------------FD----------QFFAETNDILHRTVV--------YVFSLQQATL HHVYIQEYNT--AVLFQELLSRRTSIPP--HNQ-------ELLYEGRRLS--LDSNRQAK TFPQTS---RD----------------NPIMLVS--RESVTTVGLIFED-P----SP--P KVQPRYDLDLDASY---------------------------------------------- ------------AK-------TFAGDVGHLWKTSESLLVYQKLVRK-------------- GVRGLIELI-----------------------KEDYSEILQKKSEVFHLCNY--CTQILE RTE------QLWLEV---LMQANTMSSEYD----EISDMHKKIV--RISSSL-EPLERTS QDIKTKFLPGG--------LLTDSWTQQVGT------HPEDRNV-EKIKVLLDAITA-IY ------------QQFKKD---KAERRLPYNEEQIHKFDKQKLVLHASK------------ ------------------------------------------------------------ ---ARSLFTEECAMKYRLFISKSEEWL------------RKVH---HVRKQLLT------ ----------------------LSAQLIGI-EKEVAMLMERGIK---------------L Q-EQLPQKVLPLV----------------------------------------------- ------------------------------------------------------------ ----S--SGMK---SQ------------------AYLSQNTLV----EMTLGMKKLKEEM EGVVKELAEN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NHFLERFGTLTLDGGLR------------------------ >M_musculus_ENSMUSP00000054126 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTT--NYLWHTDDLLGQGA TASVYKARNK--KSGEVVAVKVF-----NS-ASYR-RPP-----EVQVREFEVL-RRLNH QNIVKLF----AVE-----ETGGS------RQKVLIMEYCSSGSLLS--VLEDPENTFGL SEEEFLVVLRCV--VAGMNHLREN-GIV--HRDIKPGNIMRLVGEEGQSIYKLSDFGAAR KLDDD----EKFV-SVYGTEEYL-----------------------HPDMYERAVLRKPQ QKA---F-GVTVDLWSIGVTLYHAATGSLPFIPFGG--PRRNKEIMY---RIT----TEK PAGAISGTQKQENGPLEWSYSLPITCRL----SMGLQNQLVPILANILEVEEDKCWG--- ---------------FD----------QFFAETSDILQRTVI--------HVFSLPQAVL HHVYIHAHNT--IAIFLEAVYEQTNVTP--KHQ-------EYLFEGHPCV--LEPSLSAQ HIAHTA---AS----------------SPLTLFS--MSSDTPKGLAFRD-P----ALDVP KFVPKVDLQADYST---------------------------------------------- ------------AK-------GVLGAGYQALWLARVLLDGQALMLR-------------- GLHWVLEVL-----------------------QDTCQQTLEVTRTALLYLS---SSLGTE RFS---------------SGAGMPDVQERK----EATELRTRLQ--TLSEIL-SKCSHNV TETQRSLS--C--------LGEELLKNRDQI------HEDNKSI-QKIQCCLDKMHF-IY ------------KQFKKS---RMRPGLSYNEEQIHKLDKVNFSHLAKR------------ ------------------------------------------------------------ ---LLQVFQEECVQTYQVSLVTHGKRM------------RQVQ---RAQNHLHL------ ----------------------IGHSVATC-NSEARGAQESLNK---------------I F-D----QLLLDR----------------------------------------------- ------------------------------------------------------------ ----ASEQGAEVSPQP------------------MAPHPGPDP---KDLVFHMQELCNDM KLLAFDLQDN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRLIERLHRVPSAPDV------------------------- >T_guttata_ENSTGUP00000006693 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTS--NYLWLLSDILGQGA TANVFRGRQK--KTGDLYAVKVF-----NS-ISFL-RPV-----DVQMREFEVL-KKLNH KNIVKLF----AIE-----EETTT------RHKVLVMEFCPCGSLYT--VLEEPSNAFGL PESEFLIVLRDV--VAGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKEH QKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TGK PSGAISGIQKAENGPIEWSWEMPVSCSL----SKGLQVLLTPVLANILEADQEKCWG--- ---------------FD----------QFFAETSDILHRIII--------HIFSLQQMTL HKVYIHNYNT--AAIFHELVYKQTKIPS--QNQ-------ELIYEGRRLI--LEPGRLAQ HFPRTT---EE----------------NPIFVVS--REAVNIVGLIYEE-V----LL--P KVHQRYDLDGDASM---------------------------------------------- ------------AK-------AVTGIVCYACRVASSLLLYQELMRK-------------- GIRWLIEII-----------------------KDDYNEIVHKKAEIVIRLDF--CSRNIE KAE------KI-YEN---LMQINLEASEVD----EISEIHTKLL--RLSSSQ-GTIETSL QDIKTKLSPGG--------LLTDTWANQEGM------HPKDRNP-ERLQALLSSITD-IY ------------YQFKKD---KAERRLPYNEEQIHKFDKQKLYLHATK------------ ------------------------------------------------------------ ---AIALFKDECVSKYDAFLDKAEDWT------------RQAIDFFNIWKQLLA------ ----------------------LTNQCFGI-EEEVSKYQDYINE---------------L Q-DALPQKMFA-A----------------------------------------------- ------------------------------------------------------------ ----S--NGMKHTMNT------------------VYPSSNTLV----EMTLGMKKLKEEM EGVVKELAEN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NHILERFGALTMDGGLRNVD----CM--------------- >A_carolinensis_ENSACAP00000003243 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTS--NYLWLLSDILGQGA TANVFRGRHK--KTGDLYAVKVF-----NN-FSFL-RPV-----DVQMREFEVL-KKLNH KNIVKLF----AIE-----EETTS------RHKVLVMEFCPCGSLYT--VLEEPSNAYGL PETEFLIVLKDV--VAGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR ELDDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKEH QKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TGK PSGAISGVQKAENGPIEWSREMPVSCSL----SKGLQVLLTPVLANILEADQEKCWG--- ---------------FD----------QFFAESSDILHRIII--------HVFSLQQMTL HKIYIHMHND--AVMFHELVYKQTMIPA--NNQ-------ELIYEGRRLV--IEPSRLAQ AFPRTT---ED----------------NPIIVVS--REAMDIIGLLYEE-I----LL--P KVHQRYDLDSDASM---------------------------------------------- ------------AK-------TVTGVVCYACRVARALLLYQELMRK-------------- GIRWLIEII-----------------------KEDYTETLHKKTEVVLKLEF--CNRSIE KAV------EI-YQN---MLQNNLAPSEVD----EISDIHSKVL--RLSSSR-VTIETSL QEIKNKLSPSG--------LLSDSWTNQEGT------HSKDRNP-ERLQVLLGSITD-IY ------------HQFKKD---KAERRLLYNEEQIHKFDKQKLFLHATK------------ ------------------------------------------------------------ ---AMTLFKEECVSKYEAFLDKAEDWT------------RQDPFMHHLRKQLMT------ ----------------------LRKLCFDI-EKEVSKYQDYVDK---------------L Q-ENLPHKMLA-A----------------------------------------------- ------------------------------------------------------------ ----S--GGIKHAVNP------------------VYPSSNTLV----EMTLGMKKLKEEM EGVVKELAEN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NHLLERFGALTMDGGPRNVD----CI--------------- >R_norvegicus_ENSRNOP00000030127 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTT--NYLWHTDDLLGQGA TANVYKARNK--KSGEVVAVKVF-----NS-ASYR-RPP-----EVQVREFEVL-RRLDH ENIVKLF----AVE-----ETGGS------RQKVLVMEYCSSGSLLS--VLEDPENTFGL PEEEFLVVLRCV--VAGMNHLREN-GIV--HRDIKPGNIMRLVGKEGQSIYKLSDFGAAR KLDDD----EKFV-SVYGTEEYL-----------------------HPDMYERAVLRKPQ QKA---F-GVTVDLWSIGVTLYHAATGSLPFIPFGG--PRRNKEIMY---RIT----TEK PAGAISGTQKQENGPLEWSYSLPITCRL----SVGLQSQLVPILANILEAEQAKCWG--- ---------------FD----------QFFAETSDILQRTVI--------HVFSLPQAVL HHIYIHAHNT--IAIFLEAVYEQTNVAP--KHQ-------EYFFEGHPCV--LEPSLSAQ HIAHTA---AS----------------SPLTLFS--MASDTPKGLAFRD-P----ALDVP KFVPKVDLQADYST---------------------------------------------- ------------AK-------GVLGAGYQALWLARVLLDGQALMLR-------------- GLHWVLVVL-----------------------QNTCQQTLEITRTALLFLS---SSLGTE RLS---------------SGAGMLDIQELK----EATELRSRLQ--TFSEVL-SKCSHNV TETQRSLS--C--------LVGELLKSRDQI------HEDNRSI-QKIQCCLDKMHF-IY ------------KQFKKS---RMRPGLSYNEEQIHKLDKVNFSHLAKR------------ ------------------------------------------------------------ ---LLQVFQEECAQTYQVSLVTHGKRM------------RQVQ---KAQNHLHL------ ----------------------IGHSVATC-NSEARGAQESLAK---------------M F-D----QLLLDR----------------------------------------------- ------------------------------------------------------------ ----ASKQGAEVSPQP------------------MATHPGPDP---KDLVFHMQELCNDM KLLAFDLQDN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRLIERLHRVPPTPEV------------------------- >O_cuniculus_ENSOCUP00000010441 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTS--NHLWLLSDILGQGA TANVFRGRHK--KTGDLFAIKVF-----NN-ISFL-RPV-----DVQMREFEVL-KKLNH KNIVKLF----AIE-----EETTT------RHKVLIMEFCPCGSLYT--VLEEPSNAYGL PESEFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDH QKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TGK PSGAISGVQKAENGPIDWSADMPVSCSL----SRGLQVLLTPVLANILEADQEKCWG--- ---------------FD----------QFFAETSDILHRMII--------HVFSLQQMTA HKIYIHSYNT--ATVFHELVYKQTKIIS--SNQ-------ELIYEGRRLV--LEPGRLAQ HFPKTT---EE----------------NPIFVVS--REPLSTIGLIYEK-IHISVSL--P KVHPRYDLDGDASM---------------------------------------------- ------------AK-------TITGVVCYACRIAGTLLLYQELMRK-------------- GIRWLXXXX-----------------------XXXXXXXXXXXXXXXXXXXX--XXXXXX XXX------XX-YEK---LMKINLEAAELG----EISDIHTKLL--RXXXXX-XXXXXXX XXXXXXXXXXX--------XXXXXXXXXXXX------XXXXXXX-XXXXXXXXXXXX-XX ------------XXXXXX---XXXXXLAYNEEQIHKFDKQKLYYHATK------------ ------------------------------------------------------------ ---AMTHFSDECVKKYEAFLDKSEEWM------------RKML---HLRKQLLS------ ----------------------LTNQCFDI-EEEVSKYQDYTN----------------L Q-ETL-QKMFA-A----------------------------------------------- ------------------------------------------------------------ -------SGIKHTMT--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >E_caballus_ENSECAP00000018587 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTS--NHLWLLSDILGQGA TANVFRGRHK--KTGDLFAIKVF-----NN-ISFL-RPV-----DVQMREFEVL-KKLNH KNIVKLF----AIE-----EETTT------RHKVLVMEFCPCGSLYT--VLEEPSNAYGL PESEFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDH QKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KIL----TGK PSGAISGVQKAENGPIDWSGDMPVSCSL----SRGLQVLLTPVLANILEADQEKCWG--- ---------------FD----------QFFAETSDILHRMII--------HVFSLQQMTA HKIYIHSYNT--AAVFHELVYKQTKIIS--SNQ-------ELIYEGRRLV--LEPGRLAQ HLPKTT---ED----------------NPIFVVS--QEPLSAVGLIYEK-I----SL--P KVHPRYDLDGDASM---------------------------------------------- ------------AK-------AITGVVCYACRVTSTLLLYQELMRK-------------- GIRWLIELV-----------------------KDDYNETVHKKTEVVITLDF--CIRNIE KTM------KV-YEK---LIEINLEAAELG----EISDIHTKLL--RLSSSQ-GTIETSL QDIESKLSPSG--------LLTDAWAHQEGT------HPKDRHV-EKLQVLLSCITE-IY ------------YQFKKD---KAERRLAYNEEQIHKFDKQKLYYHATK------------ ------------------------------------------------------------ ---AMTHFTDECVKKYEVFLDKSEEWM------------RKML---HLRKQLLA------ ----------------------LTNQCFDI-EEEVSKYQDYTSE---------------L Q-ETLPQKMFA-A----------------------------------------------- ------------------------------------------------------------ ----S--SGMKHAMTP------------------VYPCSNTLV----EMTLGMKKLKEEM EGVVKELAEN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NHILERFGALTMDGGLRNVD----CL--------------- >M_mulatta_ENSMMUP00000010063 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTS--NHLWLLSDILGQGA TANVFRGRHK--KTGDLFAIKVF-----NN-ISFL-RPV-----DVQMREFEVL-KKLNH KNIVKLF----AIE-----EETTT------RHKVLIMEFCPCGSLYT--VLEEPSNAYGL PESEFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDH QKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TGK PSGAISGVQKAENGPIDWSGDMPVSCSL----SRGLQVLLTPVLANILEADQEKCWG--- ---------------FD----------QFFAETSDILHRMII--------HVFSLQQMTA HKIYVHSYNT--ATIFHELVYKQTKILS--SNQ-------ELIYEGRRLV--LEPGRLAQ HFPKTT---EE----------------NPIFVVS--REPLNTIGLIYEK-I----SL--P KVHPRYDLDGDASM---------------------------------------------- ------------AK-------AITGVVCYACRIASTLLLYQELMRK-------------- GIRWLIELI-----------------------KDDYNETVHKKTEVVITLDF--CIRNIE KTV------KV-YEK---LMKINLEAAELG----EISDIHTKLL--RLSSSQ-GTIETSL QDIDSRLSPGG--------SLADAWAHQEGT------HPKDRNV-EKLQVLLNCMTE-IY ------------YQFKKD---KAERRLAYNEEQIHKFDKQKLYYHATK------------ ------------------------------------------------------------ ---AMTHFTDECVKKYEAFLSKSEEWM------------RKML---HLRKQLLS------ ----------------------LTNQCFDI-EEEVSKYQDYTNE---------------L Q-ETLPQKMFA-A----------------------------------------------- ------------------------------------------------------------ ----S--SGIKHTMTP------------------IYPSSNTLV----EMTLGMKKLKEEM EGVVKELAEN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NHILERFGSLTMDGGLRNVD----CL--------------- >P_troglodytes_ENSPTRP00000008798 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTS--NHLWLLSDILGQGA TANVFRGRHK--KTGDLFAIKVF-----NN-ISFL-RPV-----DVQMREFEVL-KKLNH KNIVKLF----AIE-----EETTT------RHKVLIMEFCPCGSLYT--VLEEPSNAYGL PESEFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDH QKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TGK PSGAISGVQKAENGPIDWSGDMPVSCSL----SRGLQVLLTPVLANILEADQEKCWG--- ---------------FD----------QFFAETSDILHRMVI--------HIFSLQQMTA HKIYIHSYNT--ATIFHELVYKQTKIIS--SNQ-------ELIYEGRRLV--LEPGRLAQ HFPKTT---EE----------------NPIFVVS--REPLNTIGLIYEK-I----SL--P KVHPRYDLDGDASM---------------------------------------------- ------------AK-------AITGVVCYACRIASTLLLYQELMRK-------------- GIRWLIELI-----------------------KDDYNETVHKKTEVVITLDF--CIRNIE KTV------KV-YEK---LMKINLEAAELG----EISDIHTKLL--RLSSSQ-GTIETSL QDIDSRLSPGG--------SLADGWAHQEGT------HPKDRNV-EKLQVLLNCMTE-IY ------------YQFKKD---KAERRLAYNEEQIHKFDKQKLYYHATK------------ ------------------------------------------------------------ ---AMTHFTDECVKKYEAFLNKSEEWI------------RKML---HLRKQLLS------ ----------------------LTNQCFDI-EEEVSKYQEYTNE---------------L Q-ETLPQKMFT-A----------------------------------------------- ------------------------------------------------------------ ----S--SGIKHTMTP------------------IYPSSNTLV----EMTLGMKKLKEEM EGVVKELAEN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NHILERFGSLTVDGGLRNVD----CL--------------- >P_pygmaeus_ENSPPYP00000005386 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTS--NHLWLLSDILGQGA TANVFRGRHK--KTGDLFAIKVF-----NN-ISFL-RPV-----DVQMREFEVL-KKLNH KNIVKLF----AIE-----EETTT------RHKVLIMEFCPCGSLYT--VLEEPSNAYGL PESEFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDH QKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TGK PSGAISGVQKAENGPIDWSGDMPVSCSL----SRGLQVLLTPVLANILEADQEKCWG--- ---------------FD----------QFFAETSDILHRMII--------HVFSLQQMTA HKIYIHSYNT--ATVFHELVYKQTKIIS--SNQ-------ELIYEGRRLV--LEPGRLAQ HFPKTT---EE----------------NPIFVVS--REPLNTIGLIYEK-I----SL--P KVHPRYDLDGDASM---------------------------------------------- ------------AK-------AITGVVCYACRIASTLLLYQELMRK-------------- GIRWLIELI-----------------------KDDYNETVHKKTEVVITLDF--CVRNIE KTV------KV-YEK---LMKINLEAAELG----EISDIHTKLL--RLSSSQ-GTIETSL QDIDSRLSPGG--------SLADAWAHQEGT------HPKDRNV-EKLQVLLNCMTE-IY ------------YQFKKD---KAERRLAYNEEQIHKFDKQKLYYHATK------------ ------------------------------------------------------------ ---AMTHFTDECVKKYEAFLNKSEEWI------------RKML---HLRKQLLS------ ----------------------LTNQCFDI-EEEVSKYQEYTNE---------------L Q-ETLPQKMFT-A----------------------------------------------- ------------------------------------------------------------ ----S--SGIKHTMTP------------------IYPSSNTLV----EMTLGMKKLKEEM EGVVKELAEN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NHILERFGSLTMDGGLRNVD----CL--------------- >H_sapiens_ENSP00000329967 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTS--NHLWLLSDILGQGA TANVFRGRHK--KTGDLFAIKVF-----NN-ISFL-RPV-----DVQMREFEVL-KKLNH KNIVKLF----AIE-----EETTT------RHKVLIMEFCPCGSLYT--VLEEPSNAYGL PESEFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDH QKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TGK PSGAISGVQKAENGPIDWSGDMPVSCSL----SRGLQVLLTPVLANILEADQEKCWG--- ---------------FD----------QFFAETSDILHRMVI--------HVFSLQQMTA HKIYIHSYNT--ATIFHELVYKQTKIIS--SNQ-------ELIYEGRRLV--LEPGRLAQ HFPKTT---EE----------------NPIFVVS--REPLNTIGLIYEK-I----SL--P KVHPRYDLDGDASM---------------------------------------------- ------------AK-------AITGVVCYACRIASTLLLYQELMRK-------------- GIRWLIELI-----------------------KDDYNETVHKKTEVVITLDF--CIRNIE KTV------KV-YEK---LMKINLEAAELG----EISDIHTKLL--RLSSSQ-GTIETSL QDIDSRLSPGG--------SLADAWAHQEGT------HPKDRNV-EKLQVLLNCMTE-IY ------------YQFKKD---KAERRLAYNEEQIHKFDKQKLYYHATK------------ ------------------------------------------------------------ ---AMTHFTDECVKKYEAFLNKSEEWI------------RKML---HLRKQLLS------ ----------------------LTNQCFDI-EEEVSKYQEYTNE---------------L Q-ETLPQKMFT-A----------------------------------------------- ------------------------------------------------------------ ----S--SGIKHTMTP------------------IYPSSNTLV----EMTLGMKKLKEEM EGVVKELAEN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NHILERFGSLTMDGGLRNVD----CL--------------- >C_familiaris_ENSCAFP00000000505 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTS--NHLWLLSDILGQGA TANVFRGRHK--KTGDLFAIKVF-----NN-ISFL-RPV-----DVQMREFEVL-KKLNH KNIVKLF----AIE-----EETTT------RHKVLIMEFCPCGSLYT--VLEEPSNAYGL PESEFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDH QKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TGK PSGAISGVQKAENGPIDWSRDMPVSCSL----SRGLQVLLTPVLANILEADQEKCWG--- ---------------FD----------QFFAETSDILHRMII--------HVFSLQQMTA HKIYIHGYNT--ATVFHELVYKQTKIIS--SNQ-------ELIYEGRRLI--IEPGRLAQ HFPKTT---EE----------------NPIFVVS--QEPLSTIGLIYEK-I----SL--P KVHPRYDLDGDASM---------------------------------------------- ------------AK-------AITGVVCYACKIASTLQLYQELMRK-------------- GIRWLIELV-----------------------KDDYNETVHKKTEVVITLDF--CIRNIE KTV------KV-YEK---LMKINLEAAELG----EISDIHTKLL--RLSSSQ-GTIETSL QDIESKLSPGG--------LLSDTWAHQEGT------HPKDRHV-EKLQVLLNCITE-IY ------------YQFKKD---KAERRLAYNEEQIHKFDKQKLYYHATK------------ ------------------------------------------------------------ ---AMTHFTDECVKKYETFLDKSEEWM------------RKML---HLRKQLLS------ ----------------------LTNQCFDI-EEEVSKYQDYTNE---------------L Q-ETLPQKMFA-A----------------------------------------------- ------------------------------------------------------------ ----S--SGIKHTMTP------------------IYPCSNTLV----EMTLGMKKLKEEM EGVVKELAEN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NHILERFGSLTMDGGLRNVD----CL--------------- >O_anatinus_ENSOANP00000008566 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTA--NYLWHTDDILGQGA TASVYKARNK--KSGELVAVKVF-----NN-ASYH-RPP-----EVQVREFEVL-RKLKH QNIIKLF----AVE-----ETGNS------KQKVLVMEYCARGSLLT--VLEEPENAFGL PEEEFLVVLQCV--VAGINHLREN-GIV--HRDIKPGNIMRLVGEAGQSIYKLTDFGAAR ELADD----EKFV-SVYGTEEYL-----------------------HPDVYERAVLKKPQ QKA---F-GVTVDLWSIGVTFYHAATGSLPFVPFGG--PRRNKEIMF---RMT----SEK PAGAIAGVQKRESGPLEWSYDLPTTCQL----SGGLRAQLVPILANVLEVDQEKCWG--- ---------------FN----------QFFAETSDTLHRVVV--------HVFSLPQAVL HHVYVHAHNT--TAVFLESVFKQTNIAP--DHQ-------EYLFEGHPCL--LEPSLPAQ HLVKTS---AS----------------SPLTLLS--VEPKSPLGLTFRD-P----ALDIP KFVPKVDLLADYNT---------------------------------------------- ------------AK-------GGLGPGGGSLIWGGGGTRRWELMLR-------------- GLTWLVEML-----------------------KSSCGHSLEKTRMALLFLNH--SGQGQD RPQ---------------LTSGSCEEPERR----VVGELRARLQ--TISEIL-SGWPQSI QDTWSRLG--S--------MAAELAKSREQV------HEDRSSI-QQIECCLDKMQL-IY ------------KQFKKA---RMRPGLGYNEEQIHKLDKVNFVHLAKR------------ ------------------------------------------------------------ ---LLRIFQDDCVHKYQEALTMHGQRM------------REVH---EIRKHLQL------ ----------------------VNSTVAAC-SSEAQGTQECLRE---------------V M-SFWGCSRCPGS----------------------------------------------- ------------------------------------------------------------ ----T--EGKAARPPR------------------PSPLFKYCY---QENSMDMRELQEEM KSVTFDLQHN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NSIIESLGRVPPFPFF------------------------- >G_gallus_ENSGALP00000015982 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTS--NYLWLLSDILGQGA TANVFRGRHK--KTGDLYAVKVF-----NS-ISFL-RPV-----DVQMREFEVL-TKLNH KNIVKLF----AIE-----EETTT------RHKVLVMEFCPCGSLYT--VLEEPSNAFGL PESEFLIVLRDVVKVAGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKEH QKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TGK PSGAISGIQKAANGPIEWSWEMPISCSL----SKGLQVLLTPVLANILEADQEKCWG--- ---------------FD----------QFFAETSDILHRIII--------HIFSLQQMTL HKVYIHSYNT--AAIFHELVYKQTKIPS--QNQ-------ELIYEGRRLI--LEPGRLAQ HFPRTT---EE----------------NPIFVVS--REAVNIVGLVYEE-V----LL--P KVHQRYDLDGDASM---------------------------------------------- ------------AK-------EVTRIVCYACRVANSLLLYQELMRR-------------- GIRWLIEII-----------------------KDDYNEMVHKKTEVVIRLDF--CSRNIE KAE------KI-YEN---LMQINLESSEVD----EISEINTKLL--RLSSSQ-GTIETSL QDIKTKLSPGG--------LLADTWANQEGT------HPRDRNS-ERLQTLLSAITD-IY ------------YQFKKD---KQERRLAYNEEQIHKFDKQKLYLHATK------------ ------------------------------------------------------------ ---AIALFKDECVSKYDAFLDKAEDWT------------RKML---HTRKQLLA------ ----------------------LTNQCFDI-EEEVSKYQDYINE---------------L Q-DALPQKMFA-A----------------------------------------------- ------------------------------------------------------------ ----S--TGMKHTMNT------------------VYPSSNTLV----EMTLGMKKLKEEM EGVVKELAEN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NHILERFGALTADGGLRNVD----CI--------------- >M_musculus_ENSMUSP00000020316 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTS--NHLWLLSDILGQGA TANVFRGRHK--KTGDLYAVKVF-----NN-ISFL-RPV-----DVQMREFEVL-KKLNH KNIVKLF----AIE-----EETTT------RHKVLIMEFCPCGSLYT--VLEEPSNAYGL PESEFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDH QKK---Y-GATVDLWSVGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TGK PSGAISGVQKAENGPIDWSGDMPLSCSL----SQGLQALLTPVLANILEADQEKCWG--- ---------------FD----------QFFAETSDVLHRMVI--------HVFSLQHMTA HKIYIHSYNT--AAVFHELVYKQTKIVS--SNQ-------ELIYEGRRLV--LELGRLAQ HFPKTT---EE----------------NPIFVTS--REQLNTVGLRYEK-I----SL--P KIHPRYDLDGDASM---------------------------------------------- ------------AK-------AVTGVVCYACRTASTLLLYQELMRK-------------- GVRWLVELV-----------------------KDDYNETVHKKTEVVITLDF--CIRNIE KTV------KV-YEK---LMKVNLEAAELG----EISDIHTKLL--RLSSSQ-GTIESSL QDISSRLSPGG--------LLADTWAHQEGT------HPRDRNV-EKLQVLLNCITE-IY ------------YQFKKD---KAERRLAYNEEQIHKFDKQKLYYHATK------------ ------------------------------------------------------------ ---AMSHFSEECVRKYEAFKDKSEEWM------------RKML---HLRKQLLS------ ----------------------LTNQCFDI-EEEVSKYQDYTNE---------------L Q-ETLPQKMLA-A----------------------------------------------- ------------------------------------------------------------ ----S--GGVKHAMAP------------------IYPSSNTLV----EMTLGMKKLKEEM EGVVKELAEN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NHILERFGSLTMDGGLRNVD----CL--------------- >G_aculeatus_ENSGACP00000000485 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MTASTA--NYLWSLQDVLGQGA TASVYKARNK--RLGELVAVKVF-----NS-VSYN-RPH-----EVQMREFEML-RRLKH SNIVRLY----AVE-----ELPS-------KQNVLVMEYCSGGSLLS--LLEESENAFGL PETEFLIVLQCV--VQGMNHLREN-GVV--HRDIKPGNIMRQVGEDGKSVYKLTDFGAAR VLEDD----EKFM-SIYGTEEYL-----------------------HPDMYERAVLRKPH QKS---Y-GVSVDLWSIGVTFYHAATGSLPFAPFGG--PRKNKPTMY---KIT----TEK PMGAIAGIQRVEGGQIEWSYHLPHSCQL----SQGLAMHLVPILAGILEADQERCWG--- ---------------FD----------QFFKATTDVLQRQPV--------HLFSLHQAMA HCVYIHHYNT--VLMFLEEVASQTGIAV--QLQ-------HLLYLGHKLP--LEGNMKVA NLPHTS---HD----------------RPLILLS---GPDTNGSFPFRE-P------DTP VIPSRFDVIADYNF---------------------------------------------- ------------SK-------VIVGVVHQYLRLVQSLHTHSGLLLQ-------------- GYYSYMMMF-----------------------RGECEEAVHTIAMITIRLQC--CLTTEQ RTH---------------TL--ACYDAENK----GSTESRQRLH--LVREHL-PIYSAGI HEFHSRLN--H--------LQIEQAKLAETL-------ANDQSC-QKMEMLKQRITT-IH ------------QHYRKD---RQTGKLAYNDEQIHKFEKIHLSSHIKR------------ ------------------------------------------------------------ ---VKSLLREDCVLRYKELLATTKKWS------------SVLL---EMKTRLQD------ ----------------------FSSFSTDL-LAEVEMNEHHLNK---------------A L-DRILCTLQSKQ----------------------------------------------- ------------------------------------------------------------ ----------------------------------TGQQPEI----KDQMVSRMHHLKEEM EMLVRELQCN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NSIIESLGTVSPAEALEPNLARPSTL--------------- >D_melanogaster_FBpp0080920 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MSFLRGSV--SYVWCTTSVLGKGA TGSVFQGVNK--ITGESVAVKTF-----NP-YSHM-RPA-----DVQMREFEAL-KKVNH ENIVKLL----AIE-----EDQEG------RGKVIVMELCTGGSLFN--ILDDPENSYGL PEHEFLLVLEHL--CAGMKHLRDN-KLV--HRDLKPGNIMKFISEDGQTIYKLTDFGAAR ELEDN----QPFA-SLYGTEEYL-----------------------HPDLYERAVLRKSI QRS---F-TANVDLWSIGVTLYHVATGNLPFRPFGG---RKNRETMH---QIT----TKK ASGVISGTQLSENGPIEWSTTLPPHAHL----SQGLKTLVTPLLAGLLEENREKTWS--- ---------------FD----------RFFHEVTLILRKRVI--------HVFFTNRTSS VEVFLEPDEQ--IDNFRERIFLQTEVPL--EKQ-------ILLFNNEHLEKKVTPRTIAK AFPATT---TD----------------QPIFLYS--NDDNNVQLPQQLDLP------KFP VFPPNVSVENDASL---------------------------------------------- ------------AK-------SACSVGHECKRRVDIFTSMDILIKK-------------- GVEHFIEML-----------------------VTTITLLLKKTESFDNLLST--VIDYAD VVH----------------SMARVTKGDQE-----IKTLLTALE--NVKSDF-DGAADVI SQMHKHFVIDD--------ELNDQWTSSMHG---KKCPCKTRAS-AQAKYLVERLRD-SW ------------QHLLRD---RATRTLTYNDEQFHALEKIKVDHNGKR------------ ------------------------------------------------------------ ---IKALLLDNVNPTVAQIAECLADWY------------KLAQ---TVYLKTQI------ ----------------------LEKDVRDC-ERKLNGIRDELYH---------------- VKSELKLDVDTKT----------------------------------------------- ------------------------------------------------------------ -------------------------------------INNNNQLAKIEERNRLRVMQQQQ QEVMAVMRTN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------SDIISLLSKLGITNGSLESS--------------------- >O_latipes_ENSORLP00000019746 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------RSGELVAVKVF-----NV-LSYN-RPH-----DVQMREFEML-RKLNH SNIVRLL----AVE-----ELPS-------RHKVLVMEFCSGGSLLN--LLEEPENAFGL PETEFLTVLQCI--VQGMNHLREN-GVV--HRDIKPGNILRQVGEDGKSIYKLTDFGAAR ELEDD----EKFV-SIYGTEEYL-----------------------HPDMYERAVLRKHH QKT---Y-GVSVDLWSIGVTLYHSATGSLPFTPFEG--PRKNKPVMH---KIT----REK PIHAIAGVQRVEGGPIEWSYHLPHSCQL----SRGLKVLLVPVLAGIMEADQERCWV--- ---------------FD----------QFFTATTDILQRQPV--------HVFSLQQATA HSIYMHHYKT--VMVFFEEVASQTGISI--QQQ-------HLMYLGHDLP--LEGNMKVV NLPCTS---PS----------------QPLILLS--NSAEASTGLFFRE-P------ESP IIPSKFDVLADYNF---------------------------------------------- ------------SR-------IIVGVVHQYLRIVHLLHTHRQLLLQ-------------- GYYTYMMKL-----------------------RADCSEALHSLSLITLRFQS--CFNAHN RIH---------------KLTRLFFVSPRL---PSFQPSSQLSP--QVRERL-PLYTAGI KDCQNQME--H--------LLIEQAKLTETL-------ASDKSC-QKMEMLLQKIVA-IH ------------QQYRKD---RLIGKLAYNDEQIHKFEKLHLLSHIKR------------ ------------------------------------------------------------ ---VKSVFREECVQRYKELLGSTKTWS------------RALQ---EMENRLLG------ ----------------------FGSLSTGL-LTDLEMDEMHYNK---------------- IMDNILSTPPHQR----------------------------------------------- ------------------------------------------------------------ ----------------------------------GEQQQGITPSEKDQMVSRMHHLREEM ELLVRELQCN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NTIIERLCSLGVVDSAAAREASPARP--------------- >G_gallus_ENSGALP00000021757 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTP--NYLWSTDDLLGQGA TACVYKARSK--KSGELVAVKVF-----NK-ASYL-RPQ-----EVQMREFEML-RKLNH KNIVKLF----AVE-----ETGSS------KQKVLVMEYCSSGSLLS--ILEDPANAFGL AEPEFLVVLQCV--VAGMNHLREN-GVV--HRDIKPGNIMRLVGEDGQSIYKLTDFGAAR ELEDD----EKFV-SVYGTEEYL-----------------------HPDMYERAVLRKPQ QKA---Y-GVTVDLWSIGVTFYHAATGRLPFVPFGG--PRRNKETMY---KIT----TEK PPGAIAGVQRQENGSIEWSYELPLTCQL----SVGLKDQLVPILANILEVDQEKCWG--- ---------------FD----------QFLAETNDILHRIVV--------DVFSLQQASS HRIYIHSYNT--TSKFLDAVFKQTDIVP--HHQ-------EYFFEGHPYE--LDPNLQAH NFCRTA---RH----------------NPLTLLSCAEQPEDVVGVRYRD-P----ALDFP KFVPKVDVVADCSA---------------------------------------------- ------------AK-------SAVGAVHQALRIAQELRQCQELTVR-------------- GLHWVMIYT---------------------ALAASPARDDHSCSSLDIQDG---SHLASH RYE---------------AIPGGSALPALK----DVAAVRIRLQ--RVAEEL-SQCSHSI FDFQGALD--G--------MVSELVQYGQQA------HEDK------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >A_aegypti_AAEL005359-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------MNSFLRGST--NYVWCTTSVLGKGA TGAVFQGVNK--HNGEPVAVKTF-----NQ-LSHM-RPP-----DVQMREFEVL-RKVKH DNIVKLL----DIE-----DDQEG------RGKVIVMELCTGGSLFN--ILDDPENTYGL PQREFLLVLEHL--SAGMKHLRDN-NLV--HRDLKPGNIMKYISEDGKTIYKLTDFGAAR ELEEN----QQFV-SLYGTEEYL-----------------------HPDMYERAVLRKSI NRS---F-TANVDLWSIGVTLYHVATGNLPFRPFGG---RKNKETMH---HIT----TKK APGVISGTQTSENGPIEWSRHLPPHCQL----KAGLKFLVTPLLAGLLEESQKRMWS--- ---------------FD----------RFFYEVQHILNKKVL--------HIFYTNQATS IEVYMDPEES--FFNLKEHVMVQTKVPH--VAQ-------LLLLDSERFEQKVGVNSSGM YTSLKNIMRNT----------------NPVMLFN--IENNNVTLPGELELP------KFP SFPSGVSVENDASL---------------------------------------------- ------------AQ--------ACSVGHECKRRVENFSMLDTLMNK-------------- AVEQFAGLL-----------------------KNQLAKLCERVKHQEDIGSS--TREISD LVQ----------------IAVMN--SYQD----KASTIHTEMN--SLKAAF-QLVSDPV QQLHNRFVMEE--------SLSREWITAYRE---LRSPNKNRVN-EKAKYLVDRLRD-SW ------------QHLLRD---RATRSLTHNDEQFHALEKIKITETGKR------------ ------------------------------------------------------------ ---VKTLLNDDVRPAVEQEAESLADWY------------KKAQ---TIFLQTKF------ ----------------------LFKDVGSH-EDTLYDIRVRLVQ---------------- IKEDLKEDI--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >B_taurus_ENSBTAP00000023134 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTS--NHLWLLSDILGQGA TANVFRGRHK--KTGDLFAIKVF-----NN-ISFL-RPV-----DVQMREFEVL-KKLNH KNIVKLF----AIE-----EETTT------RHKVLIMEFCPCGSLYT--VLEEPSNAYGL PESEFLIVLRDV-EVGGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDH QKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TGK PSGAISGVQKAENGPIDWSGDMPVSCSL----SRGLQVLLTPVLANILEADQEKCWG--- ---------------FD----------QFFAETSDILHRMIV--------HVFSLQQMTA HKVYIHGYNT--ATVFHELVYKQTKIIS--SNQ-------ELIYEGRRLV--LEPGRLAQ HFPKTS---EE----------------NPIFVVS--REPLSTIGLIYEK-I----SL--P KVHPRYDLDGDASM---------------------------------------------- ------------AK-------AMTGVVCYACRIASTLLLYQELVRK-------------- GIRWLIELV-----------------------KDDYNETVHKKTEVVITLDF--CIRNIE KTV------KV-YEK---LMKINLEAAELG----EISDIHTKLL--RLSSSQ-GTIETSL QDIESKLSPGG--------LLADTWTHQEGT------HPKDRHV-EKLQVLLNCITE-IY ------------YQFKKD---KAERRLAYNEEQIHKFDKQKLYYHATK------------ ------------------------------------------------------------ ---AMTHFTDECVKKYEAFLDKSEEWM------------RKML---HLRKQLLS------ ----------------------LTNQCFDI-EEEVSKYQEYTNE---------------L Q-ETLPQKMFA-A----------------------------------------------- ------------------------------------------------------------ ----S--SGIKHTMTP------------------IYPCSNTLV----EMTLGMKKLKEEM EGVVKELAEN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NHILERFGSLTMDGGLRNVD----CL--------------- >T_guttata_ENSTGUP00000001142 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --CLFLLFSQ--KSGELVAVKVF-----NN-ASYL-RPQ-----EVQMREFEML-RKLNH KNIVKLF----AVE-----ETGSS------KQKVLVMEYCSSGSLLN--VLEDPANAFGL AESEFLIVLQCV--VAGMNHLREN-GVV--HRDIKPGNIMRLVGEDGQSIYKLTDFGAAR ELEDD----EKFV-SVYGTEEYL-----------------------HPDVYERAVLRKPQ QKA---F-GVTVDLWSIGVTFYHAATGSLPFVPFGG--PRRNKEIMY---KIT----TEK PPGAIAGIQRQENGTIEWSYELPITCRL----STGLKDQLIPILASILEVDQEKCWG--- ---------------FD----------QFFAGTNDILHRIVV--------DVFSLQQASS HRIYIHSYNT--TTKFLDAVYKQTNIVP--HHQ-------EYFFEGHLYE--LDPNLQAH NFCKTT---ES----------------SPLTLLSTSEQPEDVVGVRYRD-P----VLEFP KLVPRVDVVADCSA---------------------------------------------- ------------AK-------VGV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >A_gambiae_AGAP009565-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------MNSFLRGSM--NYVWCTTSVLGKGS TGAVFQGVNK--HNGEPVAVKTF-----NQ-LSHM-RPQ-----DVQMREFEVL-RKVNH NNIVKLL----DIE-----DDQEG------RGKVIVMELCTGGSLFN--ILDDPENTYGL PQKEFLLVLEHL--SAGMKHLRDN-NLV--HRDLKPGNIMKYISEDGQTVYKLTDFGAAR ELGEN----QQFA-SLYGTEEYL-----------------------HPDMYERAVLRKSI NRS---F-TANVDLWSIGVTLYHVATGNLPFRPYGG---RKNKETMY---HIT----TKK APGVISGTQTSENGPIEWSKHLPAHCQL----KEGLKQLVTPLMAGLLEESQGRMWS--- ---------------FD----------KFFLEVQNILNKTVL--------HIFYVNRATS IEVYLEPEQT--LVHLLEHILAQTDVPQ--ASQ-------LLLLDNELFATKVDANTSAR GYPPTD---PS----------------NPVMLFN--IENYNVILPTEWDLP------KFP TFPNGISVENDASL---------------------------------------------- ------------AK-------VACSVGHECKRRVESLSLLDTLMNK-------------- SVHQFSGFL-----------------------AGFLVKLLKRTRHLEDIEGL--ISELTK MFE----------------VAASNHETYQK----LGATILASYE--TQKSDF-QRVSEPI QQLYARFVKEE--------SLVREWNSGYRA---LRTPNKNRDS-EKAKSLVDRLRD-SW ------------QHMLRD---RATRSLTYNDEQFHVLEKVKIAETGKR------------ ------------------------------------------------------------ ---LKTLLNDGVRQAVEQEAECLADWY------------KKAQ---TIFLQTQF------ ----------------------LTKDVGAY-VDALYELREQLKQ---------------- HREDLKEEIST------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >R_norvegicus_ENSRNOP00000009260 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQSTS--NHLWLLSDILGQGA TANVFRGRHK--KTGDLYAVKVF-----NN-ISFL-RPV-----DVQMREFEVL-KKLNH KNIVKLF----AIE-----EETTT------RHKVLIMEFCPCGSLYT--VLEEPSNAYGL PESEFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDH QKK---Y-GATVDLWSVGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TGK PSGAISGVQKAENGPIDWSGDMPLSCSL----SQGLQALLTPVLANILEADQEKCWG--- ---------------FD----------QFFAETSDVLHRMVI--------HVFSLQHMTA LKIYIHSYNT--AAVFHELVYKQTKIIS--SNQ-------ELIYEGRRLV--LELGRLAQ HFPKTT---EE----------------NPIFVTS--REQLNSIGLRYEK-I----SL--P KIHPRYDLDGDASM---------------------------------------------- ------------AK-------AVTGVVCYACRTAGTLLLYQELMRK-------------- GVRWLIELV-----------------------KDDYNETVHKKTEVVITLDF--CIRNIE KTV------KV-YEK---LMKVSLDAAELG----EISDIHTKLL--RLSSSQ-GTIESSL QDINSRLSPGG--------SLADTWAHQEGT------HPRDRNV-EKLQVLLNCITE-IY ------------YQFKKD---KAERRLAYNEEQIHKFDKQKLYYHATK------------ ------------------------------------------------------------ ---AMTHFTDECVRKYEAFKDTSEEWM------------RKML---HLRKQLLS------ ----------------------LTNQCFDI-EEEVSKYQDYTNE---------------L Q-ETLPQKMLA-A----------------------------------------------- ------------------------------------------------------------ ----S--SGIKHTVAP------------------IYPSSNTLV----EMTLGMKKLKEEM EGVVKELAEN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NHILERFGSLTMDGGLRNVD----CL--------------- >C_intestinalis_ENSCINP00000011687 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MTRFGHDVNNNFGTMNPHPAHNSSPIRSTL--NYVWSTTEILGQGA TGFVFKGREK--KTGQEYAIKVF-----NS-LNYMARSL-----EARRREFEVL-RKVDH KNVVRLF----SVE-----EELTT------KHDVIIMELCPNGSLYS--MLDDPENLYGL PESEFHRVLSHI--TAGMKHLHDK-GIV--HRDLKPGNIMRSLDDDGTAVYKLTDFGAAR ELGDD----EQFM-SLYGTEEYL-----------------------HPDIYERAVLRKHA GKM---F-SATVDLWSLGVTLYHVATGMLPFRPYGG--ARRNKDVMY---RIT----TEK PSGVISGVQHSERGSIEWSRELPKTCRL----SHGFKKIFTVVLSGILECNPHKIWT--- ---------------FD----------RYFAEVEDILSKKVI--------NVFSVPNAML HKVYISPEKT--LVSFQEAVAELTEVRS--SKQ-------LLLFDGEQFE--MEQFVPVK SYPHTT---PE----------------HPLILFS--SDINDFQAITIPHTC------KPP KVKPSLSLDNDSSL---------------------------------------------- ------------AK-------VCSSTLFDIRKSVSYLLLVQILIRL-------------- SVKWFVCYL-----------------------KSRVVKLKLLRSNLQCKVDC--LRTALE IFEEHYQRETSLLTVITNLVTSPPEVNELKLYFTQITEKAKILR--QIRTEF-DQLNEST NQFDKLIIQEE--------IPSSIFVDEGSQ-------TNDRLE-ERMKVASEKSRE-IS ------------RLFKTH---KKIRRLSHSDDQLHKFEKQRLAEVCEA------------ ------------------------------------------------------------ ---SVTLFTDKSVPGCKRLHKESINWF------------SNMN---EYQKKLWN------ ----------------------CETRIMRL-SDRCQEQEESIRT----------LQRVYR DKLSLVESILKEN----------------------------------------------- ------------------------------------------------------------ ----AKPLSAASLPGPNLNVVQPSIAVPSSWPNSIDNPRSSRQRQLKQLRQGLIEAKNSL NEVRCEVQTG-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------SEILKKLSSLTANRNCASPETPSRPCVPMRTND-------- >D_rerio_ENSDARP00000087779 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------Q--KTGDLYAVKVF-----NN-LSFL-RPL-----DVQMREFEVL-KKLNH KNIVKLF----AVE-----EESNT------RHKVLVMEYCPCGSLYT--VLEEPTNAYGL PEDEFLIVLQDV--VAGMNHLREY-GIV--HRDIKPGNIMRVIGDDGFSVYKLTDFGAAR ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDH QKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TEK PPGAISGHQKFENGKIEWSSEMPISCSLVCAYSRGLQSLLTPVLANILEADQEKCWG--- ---------------FD----------QFFAETSDILHRIVV--------YVFSLQQATL HHVYIHTYNT--ANLFQELLFRRTNITP--SHQ-------ELLYEGRRLV--LDPNRQAQ TFPKTS---RD----------------NPIMLLC--RDPVNTVGLLFED-P----SP--P KVQPRYDLDLDASY---------------------------------------------- ------------AK-------TFAGDVGYLWKTSDSLLLYQELVRK-------------- GVRGLNELI-----------------------RDEYSETMHKKTEVFHLCSH--CSQTLE RSH------PA-IHP---YVQSFICSSVHP----SIHPSFHLFICSFIHPSI-HLFIHSS VHSSIHSFICS--------FIHPSICSFIHSFIYLFIHSSVHSF-IHSSIHLLIYLF-IH ------------SSVHPS---IHPSVQSFICSSVHP------SIHPSI------------ ------------------------------------------------------------ ---HPSFHLFICSFI-------------------------------HPSIHLFI------ ----------------------HSSVHSSI-HSFICSFIHLIYL---------------F I-HSFIHLLIHSF----------------------------------------------- ------------------------------------------------------------ ----A--SGII---NK---------------------SQNRMLYFMNMMIFAMKKLKEEM EGVVKELAEN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NLFLERFGSLTVDGGMRTVE----RM--------------- >O_anatinus_ENSOANP00000015719 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KTGDLFAVKVF-----NS-ISFL-RPM-----DVQMREFEVL-KKLNH KNIVKLF----AIE-----EETTT------RHKVLVMEFCPYGSLYT--VLEEPSNAYGL PESEFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDH QKK---Y-GATVDLWSIGVTFYHAATGALPFRPFEG--PRRNKEVMY---KII----TGK PSGAVSGVQKAENGPIDYSGDMPISCNL----SRGLQALLTPVLANILEADQEKCWG--- ---------------FD----------QFFAETSDILHRIII--------HVFSLQQMTA HKIYIHSYNT--AAVFHELVYKQTKILS--PNQ-------ELIFEGRRLV--LEPGRLAQ HFPKTS---EE----------------NPIIIVS--RDPMSTVGLIYEK-I----SI--P KVHPRYDLDSDASV---------------------------------------------- ------------AK-------AVTGVVCYACRVASSLLLYQELMRK-------------- GVRWLIELI-----------------------REDYNETVHKKTEVVITLDF--CIRNIE KTR------KV-YEK---LMHINLESAELG----EISDIHTKLL--RLSSSR-GTIETSL QDIKSKLSPGG--------LLADTWANQEGS------HPKDRNI-ERLQVLLNCIME-IY ------------HQFKKD---KAERRLAYNEEQIHKFDKQKLYYHATK------------ ------------------------------------------------------------ ---AMSQFTDECIEKYEVFLDKAEEWM------------RKML---HLRKQLLT------ ----------------------LTNQCFDI-EEEVSKYQDYTNE---------------L Q-ETLPQKMFA-A----------------------------------------------- ------------------------------------------------------------ ----S--SGIKHTMNP------------------IYPSSNTLV----EMTLGMKKLKEEM EGVVKELAEN-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NHILERFGALTMDGGLRNVD----CL--------------- >P_pygmaeus_ENSPPYP00000021585 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MGNAPAKKDT------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EQEKSATEFLVKARGDFLYRWGNPAQNTAS--SDQFERLRTLGTGS FGRVMLVRHR--ETGGHYAMKIL-----HK-QKLV-KLKQV---EHTLNEKRIL-QAIDF PFLVKLQ----FSF-----KDN--------SYLYLVMEYVPGGEMFS--HLRRVGSF--- SEPHACFYAAQV--VLAFQYLHSL-DLI--HRDLKPENLLID----QQGYLRVTDFGFAK RVKGR----TW---TLCGTPQYL-----------------------APEIIL-------- SKG---Y-NKAVDWWALGVLIYEMTVGFPPFY------ADEPIQIYE---KIV----SGR ---------------------VRFPSKL--------SSDLKDLLRSLLQVDLTKRFG--- ---------------------------NLRNGVGDIKNHKWF--------ATTSWI--AI YEKKVEAPFI-------PKYTGPGDASNFDDYE-------EEELRISINEKCAKEFSEF- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >T_rubripes_ENSTRUP00000005140 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------Q--KTGDLYAVKVF-----NN-LSFL-RPL-----DVQMREFEVL-KKLNH KNIVKLF----AVE-----EESNT------RHKVLVMEYCPCGSLYT--VLEESSNAYGL PEDEFLIVLHDV--VAGMNHLREY-GIV--HRDIKPGNIMRVIGEDGRSVYKLTDFGAAR ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDH QKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TEK PPGTISGHQKCENGKIEWSNEMPVSCSL----SKGLQSLLTPVLANILEADQEKCWG--- ---------------FD----------QFFAETNDILHRT-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >C_elegans_T25E12.4a MDANDYPRLYYTSMPSSSTSMVTTTRFSTSFSPSIPCHRQENFRRHSTSALAKRNGSESE KSAEIRENPDEIEVSRVSGRDSSLAFYTTAHETSSMLSRDSRDETLTPNEHIHQASSRRV SANDSVFEDGYVDFVDEPREHGSRRKSFEKFTDRNGEEKEGRVFELSTPQPTREAAPGAH QFQLPTLLVTSTPTTVFDHSDDEVWTPYRPPPNREYSSSSEPMMGDLTFRLQSGIHKKSI AVEGTEIALRDLRNEALQFIKEIYPEKGCSSLEDYILLYKHDLRSINILQLITTSSDVTD GTLVEVVIGSCPQNERIVVHPHTLFVHSYKVPTFCDFCGELLFGLVKQGLKCFGCGLNYH KRCASKIPNNCNGSKQRRPSAIPLSPSNSNILNLNERRHSRRESCLEALDAARPSSTLGG AATPNIFITSDDCGDAVGGNYLQMPRKDRSCSWSGRPLWMEIAEATRVKLQVPHTFQVHS YKLPTVCQHCKKLLKGLIRQGMQCRDCKYNCHKKCSEHVAKDCSGNTKASQFFLGSQADD GASEDRDDDLSLRSGSGAHKKAQNTPSAPLQGSEGSGSPGPVVSFAANALSNMPDDDVIS SESANIPLMRVVMSKKQTKRKNNKLLKEGWIVHYTDQQNMRKKHYWRLDTKGITMYQDEN TTRYYKEIPLNEILNVSMSPPDKTADYLFEIRTGVCVYFISGSPSDEKGSSLDAQSWTTA IQSALMPVTPQSSVVGGKRIDKLKVPTEGETGHLGAKIQTEHEFSQLYQIFAEEVLGSGQ FGTVYGGIHR--RNGQHVAVKLI-----DK-LKFPPNKE-----DLLRAEVQIL-EKVDH PGVVHFM----QML-----ETT--------DRIFVVMEKLKGDMLEM--ILSSEKGR--L SERTTQFLVAQI--LEALRYLHHL-NIV--HCDLKPENILLNSNS-DFPQVKLCDFGFAR IIGEK----SFRR-SVVGTPAYL-----------------------APEVLR-------- NKG---F-NRSLDMWSVGVIVYVSLSGTFPFN--------EDEDIND---QIQ----NAE ---------------------FMYPPTP----WKEISENAIEFINGLLQVKMSKRYT--- --------------------------------VTKAQSQIWMQ-------NYTLWSDLRV LEKAVGQRFV--------------------THE-------SDDVRWQAYEKEHNVTPVYV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >H_sapiens_ENSP00000366488 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MGNAPAKKDT------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EQEESVNEFLAKARGDFLYRWGNPAQNTAS--SDQFERLRTLGMGS FGRVMLVRHQ--ETGGHYAMKIL-----NK-QKVV-KMKQV---EHILNEKRIL-QAIDF PFLVKLQ----FSF-----KDN--------SYLYLVMEYVPGGEMFS--RLQRVGRF--- SEPHACFYAAQV--VLAVQYLHSL-DLI--HRDLKPENLLID----QQGYLQVTDFGFAK RVKGR----TW---TLCGTPEYL-----------------------APEIIL-------- SKG---Y-NKAVDWWALGVLIYEMAVGFPPFY------ADQPIQIYE---KIV----SGR ---------------------VRFPSKL--------SSDLKHLLRSLLQVDLTKRFG--- ---------------------------NLRNGVGDIKNHKWF--------ATTSWI--AI YEKKVEAPFI-------PKYTGPGDASNFDDYE-------EEELRISINEKCAKEFSEF- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >P_troglodytes_ENSPTRP00000035898 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MGNAPAKKDT------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EQEESVNEFLAKARGDFLYRWGNPAQNTAS--SDQFERLRTLGMGS FGRVMLVRHR--ETGGHYAMKIL-----NK-QKVV-KMKQV---EHILNEKRIL-QAIDF PFLVKLQ----FSF-----KDN--------SYLYLVMEYVPGGEMFS--RLQRVGRF--- SEPHACFYAAQV--VLAFQYLHSL-DLI--HRDLKPENLLID----QQGYLQVTDFGFAK RVKGR----TW---TLCGTPEYL-----------------------APEIIL-------- SKG---Y-NKAVDWWALGVLIYEMAVGFSPFY------ADQPIQIYE---KIV----SGR ---------------------VRFPSKL--------SSDLKDLLRSLLQVDLTKRFG--- ---------------------------NLRNGVGDIKNHKWF--------ATTSWI--AI YEKKVEAPFI-------PKYTGPGDASNFDDYE-------EEELRISINEKCAKEFSEF- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >A_carolinensis_ENSACAP00000002909 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MEQYHVLEMIGEGS FGRVYKGRRK--YTTKIVALKFI-----PK-VGRSQKEL-----KNLQREIEIM-RGLHH PNIVQML----DSF-----ETD--------KEVVVVTDYAE-GELFQ--ILEDDGN---L PEEQVQIIASQL--VSALYYLHSH-RIL--HRDMKPQNILLG----KGGVIKLCDFGFAR AMSIH----TMVLTSIKGTPLYM-----------------------SPELVE-------- EKP---Y-DHTADLWSVGCILYELYVGTPPFY------TNSIFQLVS---LII----KDP ---------------------VKWPKNM--------SLHFKSFLQGLLMKNPHERLS--- --------------------------------WPELLYHPFIA-------GKVTVIDDTV DQGIVNPFTSKLPPDLQALKEQQAHSLTPPSGQ-------SKILRKARQKMAQEARRKEM GKPKASLKGEVSKESETYSRKACLAQTDSSRQHQKLPGMEEHLALGEKETEWEQKEPSSK LQENWITQDYEREFQEMKPESRRSIDTVDLETEEMDSDEEWQHFIDATNSTHVHLSAPLS LLGDPAFVQRIRVRLKDSGQQVLEGMLEGASHLRPALHVISNLLGTCCDSDLLCSFCNDI GLPQFLMQLVESILKSFNIKQQPWHITLLTDLMAVMTV------FFASDFNR--EKDGKK QSLQAFQSSANHFLTLLPALLAQPTDQEGRLREQSLVCFTHLCQSMDNACPSISIPFYTS LLENHCPLLDT--------LCHGVSCEQIIQEVPPKEARSKQ---HWNELMGAAFAKALA ASCVIPGRHTVCQKAKKKISQYIAEKLTEKENRLLASLILAVNHPASSLHGLKVLYACGH VSQTLCHHL-ATPEMLNSLICHLQGKVFIHSYLCYKENCLVLFSLLMLQLQFLPSQTYLI RN-LGTACTHSIPNRRVSAAALLLTYFIQHGAAVKLRWEEALTAIATAFTESAEPCLPPP MGVGFYDGLLILLLHVLSEVCGDVAMVREFAASELWGIVWHLFAM--VLHMTTQEPMLEG ETSGAGQHAPEPDWDLISPQGTPFFLSLTLFVFTCEPHQCLLQMAQPNGLIMAVLNKLLD PDFLEQL-HEDGDLELVTTTVLQVCQVFCFAFAMDMDPEILEQILTNMKGSEIPAQLLQV CIHHLPCTKTELPLSLLCRLVLSDEEIIEQVVGA-ATSQDAIDFLSSIFLSDQVHLLADL LTLLTHIARA-SPSHLPFLEKLLSGSTSQ--ALSHLLGHSECLVRARTCSLVGNLLRHGQ EFPHILQGQVGLLKSLLERLSDEDRHVRRSASFAVGNAAYQAGPFMQDLRKAVPCVVRLL GDPQAKTRCNAASALGNLGWQSVELGDSLIQNKAPNILLDVACHDSQPAVQKAALIALRS MSHQPRIRQVLVSLRACEKLEALTLDQ--FQNSAYSHPWPSSTQHCKKLIQLLQPSQSA >M_mulatta_ENSMMUP00000026815 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MGNAAAKKD-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------TEQETVNEFLAKARGDFLYRWGNPAQNTAS--SDQFERLKTLGTGS YGRVMLVRHR--ETGNHYAMKIL-----DK-QKVV-RLKQV---EHTLNEKRIL-QAINF PFLVKLQ----FSF-----KDN--------SNLYLVMEYVPGGEMFS--HLRRVGRF--- SEPQACFYAAQV--VLAFQYLHSL-DLI--HRDLKPENLLID----QQGYLQVTDFGFAK RVKGR----TW---TLCGTPEYL-----------------------APEIIL-------- SKG---Y-NKAVDWWALGVLIYEMTAGFPPFY------ADQPIQIYE---KIV----SGK ---------------------VRFPSQL--------SPDLKDLLRSLLQVDLTKRFG--- ---------------------------NLKNGVGDIKNHKWF--------ATTNWI--AL FEKKVEAPFI-------PKYTGPGDASNFDSYE-------EEEIRISVNEKCASKFAEF- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >A_carolinensis_ENSACAP00000008611 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MNRYTTIKQLGDGT YGSVILGRSN--ESGELIAIKRM-----KR-KFYS-WEE-----CMNLREVKSL-KKLSH ANVVKLK----EVI-----REN--------DNLYFVFEYMKE-NLYQ--LMKERNKL--F PESTVRNIMYQI--LQGLAFIHKH-GFF--HRDLKPENLLCM----GPELVKIADFGLAR EIRSR----PPYT-DYVSTRWYR-----------------------APEVLLR------- STN---Y-SSPIDIWAVGCIMAEVYT-LRPLFP-----GASEIDTIF---KICQVLGTPK KNDWSEGYQLAGTMNFRWPQCVPNNLKT---LIPNASSEAIQLMRDMLQWDPKKRPT--- --------------------------------ASQALRYPYFQVGQALG-PSRCIQEGGK -QRDVPEKTQ----IHIKPIPP--------AQP-------PPKAQVRLSFRPFQQNQPSH SVIYPYKTGSSLSD---NLREDKPSQMALPNIRS-------------------------- KMPQHKIDVATEKT---------------------------------------------- ----------------------------------NGELKPKNRRRW-------------- G-----------------------------------------------------HIDGTL KSSEDWEDLGGCEVAKN----DFKNKG-QG------------------------------ ----DEAFCRQ----------EVILDLKPSVCLGTGNSAP---SYLRQDTPTLQVSTAKQ ------------HYLKHS---RYLPGISTRNNVMSSSSKDSIPSNLWP------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PSSLPIKTSGVAGGIARL---NSSKKCHTGSNG LTAAYIPSFLKKE----------------------------------------------- ------------------------------------------------------------ ----VGSAGQRVHLAPIIDPSSLDPSSAYTSLKSVGPHIGRTSFNIPVKST--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SALLPHPPPVQPVHGRTDWSLKYGAHR >O_latipes_ENSORLP00000008832 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------AAIFTHN------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MFLFAVKEFLAKAKEDFLKKWENPAQQTAA--LDHFERLKTLGTGS FGRVMLVKHK--ETGQHFAMKIL-----DK-QKVV-KLKQI---EHTLNEKRIL-QAVSF PFLVQLE----HSF-----KDT--------SNLYMVMEYVPGGEMFS--HLRRIGRF--- SEPHARFYAAQI--VLTFEYLHSL-DLI--YRDLKPENLLID----QQGYIQVTDFGFAK RVKGR----TW---TLCGTPEYL-----------------------APEIIL-------- SKG---Y-NKAVDWWALGVLIYEMAAGYPPFF------ADQPIQIYE---KIV----SGK ---------------------VRFPSHF--------SSDLKDLLRNLLQVDLTKRFG--- ---------------------------NLRNGVNDIKGHKWF--------ATTDWI--AI YQRKVEAPFI-------PKCKGPGDTSNFDDYE-------EEEIRVSFSEKCAKEFAEF- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >G_aculeatus_ENSGACP00000024909 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MGNAPTARKG------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SEMESVKEFLAKAKEDFLKKWESPAQNTAG--LEQFERLKTLGTGS FGRVMLVKHR--ETGQHYAMKIL-----NK-QKVV-KLKQI---EHTLNEKRIL-QAVSF PFLVRLE----YSF-----KDN--------TNLYMVMEYVPGGEMFS--HLRRIGRFSVH SEPHARFYAAQI--VLTFEYLHAL-DLI--YRDLKPENLLID----QQGYIQVTDFGFAK RVKGR----TW---TLCGTPEYL-----------------------APEIIL-------- SKG---Y-NKAVDWWALGVLVYEMAAGYPPFF------ADQPIQIYE---KIV----SGK ---------------------VRFPSHF--------SSDLKDLLRNLLQVDLTKRFG--- ---------------------------NLKNGVNDIKGHKWF--------ATTDWI--AI YQKKVEAPFV-------PKFKGPGDTSNFDDYE-------EEEIRVSFNEKCGKEFAEF- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >P_pygmaeus_ENSPPYP00000023332 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MLLLKKHTEDI--SSVYEIRERLGSGA FSEVVLAQER--GSAHLVALKCI-----PK-KALR-GKE-----ALVENEIAVL-RRISH PNIVALE----DVH-----ESP--------SHLYLAMELVTGGELFD--RIMERGS---Y TEKDASHLVGQV--LGAVSYLHSL-GIV--HRDLKPENLLYATPF-EDSKIMVSDFGLSK IQAGN-----MLG-TACGTPGYAEPVTLSGMAACVPVRASVCLWPPAPELLE-------- QKP---Y-GKAVDVWALGVISYILLCGYPPFY------DESDPELFS---QIL----RAS ---------------------YEFDSPF----WDDISESAKDFIRHLLERDPQKRFT--- --------------------------------CQQALQHLWISGD-----TAFDRDILGS VSEQIQKNFA------RTHWKRAFNATSFLRHIRKLGQSPEGEGASEQGMARHSHSGLRA GQPPKW------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >D_melanogaster_FBpp0081883 ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MSVDNSLGILDLS SGKESEKTAMTAANKENDPDSHFTGTIVTTGATAQPATPTTSNATALP------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------ATPTVAAGQDLGDGACSSKNTDSKFQSYVNGNG--NGVYKIIKTLGKGN FAKVKLAIHV--PTGREVAIKVI-----DK-TQLNTSAR-----QKLYREVKIM-KLLNH PNIVRLF----QVI-----ESE--------RTLYLVMEYASRGELFD--HLVKNGRM--- RERDARVIFRQL--VSAIQYCHSK-FVV--HRDLKAENLLLD----QHMNIKIADFGFGN TFDPN----AQLE-TFCGSPPYA-----------------------APELFM-------- GRK---YAGPEVDAWSLGVVLYTLVSGSLPFD------GGTLKELRE---RVL----RGK ---------------------YRVPYYI--------SMDCENLMRKFLVLNPAKRTS--- --------------------------------LSAVMSDKWINLG-----HDESDRLRPF REKPMELQDAARFDLLMSMGHKRRDVEQSVKGQLFDDIYCTYMLLGVAKPRSSNRSTKPE AIPTVDLTTPAVSSPLPNITTPTVTIAHVTLALDKNPPIHSSSASGRPIAPRLANAPNTP TSTPPTGPPAKPT----------------------------------------------- ------------------------------------------------------------ --------------------------------RRTPARTPARKATNHTSGQGRPEPSSLP HTPQSKRASANMDVKPTLLSAQRQLAQTQKLANTPPRFQYPVAQTPNQAQGSSRRPTTLY EKAEPAVTPLL--------VPKSPAMGARLLERIPGGGAVEKTSDKPFTRQNVARATFHF GQARSGKRGGGSGNGAGGEEDSYQTPPLSADDTKPASRVGFFSKLTAR------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------FGRRVIHLNEKDVTEQRKNLTK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >M_domestica_ENSMODP00000019211 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------LISSSSSRLRDPGALMMEKYHVLEMIGEGS FGRVYKGRKK--YSAQVVALKFI-----PK-LGRSDKEL-----RNLHREIEIM-RGLRH PNIIQML----DSF-----ETD--------KEVVVVTDYAE-GELFQ--ILEDDGK---L PEDQVQAIAAQL--VSALYYLHSH-RIL--HRDMKPQNILLA----KGGGIKLCDFGFAR AMSTN----TMVLTSIKGTPLYM-----------------------SPELVE-------- ERP---Y-DHTADLWSVGCILYELAVGTPPFY------TTSIFQLVS---LIL----KDP ---------------------VRWPPTI--------SQCFKSFLQGLLTKDPRQRLS--- --------------------------------WPELLYHPFIA-------GRVTMTSETV TSDLGTPFTSRLPLELQALKEEQTNWLTPKGGQ-------SRILRQARKRMAEDTRQKTH LNPGTSLE-QVEKASKAVPVAALLPRLGATSQDLDFLSRTPSPEDKKDWAEWEASEPPQP TREPQVTQEYDQEFPELKQEAEES-SVGTLEPEEPDSDSEWQHLLEPTAPSDIQLKAPLT LLCNPDFCQRVQNQLHGAGGQVLEGILDGASRLLPTLRVVKSLLTTCSDSALLYAFCREA GLPGLLLNLLRHSQSSVNIQQQPWCGTFLRDLVATIQA------YFAGNFNL--EKSQTS DSLHVFQEAANLFLNLLGKLLAQPDDAEQTLRRDSLMCFTDLCKTMDGSNLAISKSFYCS FLTTHKPVLDG--------LLHGMALPQLPLHTPPGAPQVSQPLREQDEDLPRAFATALA AICTLPVGLPGCWEAKEQVSKHLADQLTDDSSQLRPYLFSSLQHPSLSLHLLKVLYACCH VNENLCRRLDQEPLALESLLLLVQGKVDVIDPEETAEATLHLLSLLVLRLQVLPPGVKKI GNELAVLFVHSPVVSLVSAAAGLLSQLSQQGVAFNLQPKEWIAAAAHALSAPAE--LPP- -GCFLFQ--------------GGAEIVQDVANSELWTILWHRFFM--TLRLSEEVPTSED KMSLPSQSVPEPEWTLISPQGITALLNVALAVFTQEPHLCLPYLIQHNSILMSTLKHLLS PIFLQQLGQTQHGSELLPAVVLPVCQLLCFPFAMDVDVDVLLNILADLRDSEVPAHLLQV CCRYLLLPQAELPVSLLARLALTDSTTLNQFVASVAASPNTITFLSAALLGDQPLLTSDI LSLLAHAARAWPPTHLPFLQDLLAGPDESYWPLRCLLGHPENPVRARAYGLLGHLLHQST ALRGALQSQAGLLSLLLAGLRDKDPAVRRSASFAVGNAAYQAGPLAPALVPAVPRVTQLL GDPQTGTRRNAASALGNLGPEG--LGEELLRCQVPHRLLETACGDPQPTVREAALIALRS LRQEPSIHQVLVSLDASEKLASLSSASPLPPHSSSGSPRPSSARHCKKLIHLLRPAHST >O_cuniculus_ENSOCUP00000002072 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MLLLKKQTADI--SSVYELREKLGSGA FSEVVLAQER--GSAHLVALKCI-----PK-NALR-GKE-----ALVENEIAVL-RRVNH PNIVALE----DVH-----ESP--------SHLYLAMELVTGGELFD--RIMERGS---Y TEKDASHLVAQV--LGAVSYLHSL-GIV--HRDLKPENLLYATPF-EDSKIMVSDFGLSK IQAGN-----MLG-TACGTPGYAESATRSTHA-----RACVRLWPPAPELLE-------- QKP---Y-GKAVDVWALGVISYILLCGYPPFY------DESDPELFS---QIL----RAS ---------------------YEFDSPF----WDDISESAKDFIRHLLERDPQKRFT--- --------------------------------CQQALQHLWISGD-----AASDRDILGS VSEQIQKNFA------RTHWKRAFNATSFLRHIRKLGQSPEGEQASQQTPACHSHPGLLT GQPPKW------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >D_rerio_ENSDARP00000013244 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------YAHNHTLSLS------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LSLCTVKEFLAKAKEDFLKKWENPAQNTAS--LDHFERLKTLGTGS FGRVMLVKHK--ESGQHFAMKIL-----DK-QKVV-KLKQI---EHTLNEKRIL-QAVSF PFLVRLE----HSF-----KDN--------TNLYMVMEYVPGGEMFS--HLRRIGRF--- SEPHARFYAAQI--VLTFEYLHSL-DLI--YRDLKPENLLID----QQGYIQVTDFGFAK RVKGR----TW---TLCGTPEYL-----------------------APEIIL-------- SKG---Y-NKAVDWWALGVLIYEMAAGYPPFF------ADQPIQIYE---KIV----SGK ---------------------VRFPSHF--------SSDLKDLLRNLLQVDLTKRFG--- ---------------------------NLKNGVNDIKGHKWF--------ATTDWI--AI YQKKVEAPFI-------PKCKGPGDTSNFDDYD-------EEEIRVSITEKCGKEFAEF- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >T_guttata_ENSTGUP00000006427 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------IVSEGDP--KTKYTEFVHIGQGG FGTVYKAINP--ATGDVVALKKM-----PL-RKRS-RN------ELVVNEIQVM-KENRH PNIVNYI----DSY-----LVN--------EDLWLVMEYVDGGTLTS--VLVQVF----M EERIIAAISREC--LKALDFLHSK-NVI--HRDVKSDNILLG----MDGSVKLTDFGLCA QLTQE---RSTRC-TVLGTPYWV-----------------------APEILK-------- RKE---Y-NTQVDVWALGIVAIEMLEGEPPYF------KESPIQAQR---LIA----RNR HPP------------------LKMSSKM--------SYLFHAFLHSCLDSDPSTRWT--- --------------------------------ARELLQHPFLQ-------TAVSLSVL-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >O_latipes_ENSORLP00000018527 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------NAAQQPSN------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SVRDKVKEFLAKAKEDFLKKWENPSQNTAN--LEQFERLKTLGTGS FGRVMLVKHR--ETGQHYAMKIL-----NK-QKVV-KLKQI---EHTLNEKRIL-QAVSF PFLVRLE----FSF-----KDN--------TNLYMVMEYVPGGEMFS--HLRKIGRF--- SEPHARFYATQI--VLTFEYLHAL-DLI--YRDLKPENLLID----QQGYIQVTDFGFAK RVKGR----TW---TLCGTPEYL-----------------------APEIIL-------- SKG---Y-NKAVDWWALGVLVYEMAAGYPPFF------ADQPIQIYE---KIV----SGK ---------------------VRFPSHF--------SSDLKDLLRNLLQVDLTKRYG--- ---------------------------NLKNGVNDIKGHKWF--------AATDWI--AI FQKKVEAPFV-------PKFKGPGDTSNFDDYE-------EEEIRVSFSEKCAKEFAEF- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >M_domestica_ENSMODP00000023457 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MHRYTTIKQLGDGT YGSVLLGRSI--ESGELIAIKKM-----KR-KFYS-WEE-----CMNLREVKSL-KKLNH ANVVKLK----EVI-----REN--------DHLYFVFEYMKE-NLYQ--LMKERNKL--F PESAIRNIMYQI--LQGLAFIHKH-GFF--HRDLKPENLLCM----GPELVKIADFGLAR EIRSR----PPYT-DYVSTRWYR-----------------------APEVLLR------- STN---Y-SSPIDIWAVGCIMAEVYT-LRPLFP-----GASEIDTIF---KICQVLGTPK KNDWPEGYQLSSSMNFRWPQCIPNNLKS---LIPNASSEAIQLMRDMLQWDPKKRPT--- --------------------------------ASQALRYPYFQVGHPLGSTPHSLQEPGK PQKEFHEKMG--PPPHMKPVPP--------AHP-------PAKPQPRISSRAHQPSQPPQ HLIYPYKTEASPADPESQLPGDQPHPVHFPALHN-------------------------- KIPQTKILAGMEHP---------------------------------------------- ----------------------------------NGEIKPKSRRRW-------------- G-----------------------------------------------------PVSRST KDSDDWDDLDDFDFNPSLTRTDLKNKKRQS------------------------------ ----DETLCR-----------QSVLDLKPSEPIGTGNSAPTHTSYQRQDTPTLR-SVAKQ ------------HYLKHS---RYLPGIPIRNGILPNPGKDFLPPNSWS------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GSSLSGKSSGSISEISRM---NSVVSGYLGSSR LTSGYFPSFLKKE----------------------------------------------- ------------------------------------------------------------ ----VGSAGQRVHLAPI-----SDPPPGYASLKSVRPHHNRPLFHTQPRST--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PGLLPRPPAAQPVHGRTDWVSKYASRR >A_carolinensis_ENSACAP00000009974 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ADV--EKCYKIGRTIGDGN FAVVMECHNC--NTNQNYAMKII-----DK-SKLK-GKE-----DMLDNEILII-KSLSH PNIVSLI----EVF-----ETD--------AEIYLVLEYIPGGDLFD--AIIESVK---F TECDAALMITDL--CEALVYIHSK-NIV--HRDLKPENLLVQRNPDKTTTLKLADFGLAK KVTKP------IF-TVCGTPTYV-----------------------APEILA-------- ENG---Y-GLEVDMWATGVILYILLCGFPPFRSH----ERDQEELFQ---IIQ----LGH ---------------------YEFLSPY----WDNISPAAKDLINRLLVVDPKKRYT--- --------------------------------AQQVLQHLWI--------DTAGKNNSRN LQKEVTINL-------------------------------ERHFRSQRK----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >D_rerio_ENSDARP00000002825 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MGNTPAAKRG------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------NEMESVKEFLAFAKEDFLRKWENPAQNTAC--LEDFDRLKTLGTGS FGRVMLVRHR--ETGQHYAMKIL-----NK-QKVV-KLKQI---EHTLNEKRIL-QAVSF PFLVRLE----YSF-----KDN--------TNLYMVMQYVQGGEMFS--HLRRIGRF--- SEPHARFYASQI--VLTFEYLHAL-DLI--YRDLKPENLLID----QQGYIQVTDFGFAK RVKGR----TW---TLCGTPEYL-----------------------APEIIL-------- SKG---Y-NKAVDWWALGVLMYEMAAGYPPFF------ADQPIQIYE---KIV----SGK ---------------------VRFPSHF--------SSDLKDLLRNLLQVDLTKRYG--- ---------------------------NLKNGVNDIKGHKWF--------STTDWI--AI YQRRVEAPFV-------PKCRGPGDTSNFDDYE-------EEEIRVSFTEKCAKEFAEF- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >A_aegypti_AAEL004761-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MNRYLTLSQLGDGT YGTVVLGQRK--DTGEKVAIKRM-----KR-KYYS-WEE-----AMNLREVKSL-KKLSH ANVVKLK----EVI-----REN--------DVLYFVFEYMQE-NLYQ--LIKDRENH--F PEATIRLILQQI--LTGLAFMHRH-GFF--HRDLKPENVLCC----GPELVKIADFGLAR EIRSR----PPYT-DYVSTRWYR-----------------------APEVLLH------- STR---Y-GSAIDLWAVGCIMAELYT-FRPLFP-----GSSEVDQLF---KICSVLGTPD KNDWPDGHKLAVTIQFRFPECPKIPLES---LVTRASSSGIQLLEDFLKWEPEKRPT--- --------------------------------AQQSLKYPYFASVKQRT-SATIVGNGNV QLPQIQQNGNGIPNARISIVDA------------------AQVENSGITSR-FSVNPNTV SVNNGNINGSIYKSISNSDLNDINSLLSLSRLSQ------------------------NP SMPEKRSSLDNGKL---------------------------------------------- ----------------------------------NDSAKSNGKYQS-------------- GINYSVL------------------NEMLNNYNLGINGGLSHGNQHQGRLN---RNSSIT KSITDRSDSGVNDNGSSVTSYSIIKPAIVK---------------IEEKPTEVYVAGRKG EKVNDIYVTRNSGNGGRVGAIRAAVDSDDSSYFNSGFYLHKQTSNSKSDLFNE------- ------------SFLNDS---KVYNAFSKQPVLLARKTDDDIKVNITK------------ ------------------------------------------------------------ ----NPLLNRGLQSNFSRSWEPVNGNS--------------------------------- ----------------------FDDDLEDILGSRIKSTKKSNAEFKLEDLFGTVSFGKDT KISKYPNTVPFAK----------------------------------------------- ------------------------------------------------------------ -----GAMKKGDELTDIFDN--SDAKPSHSSANIVPRRKNQQVFVSNGSFAAGNEFNGVN ASFKLFPWED-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------APRNVPDKKQWVPDSGVLTYVGPSGDGKGRPDWAAKYLSK- >M_mulatta_ENSMMUP00000018568 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MGNAAAAKKG------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SEQESVKEFLAKAKEDFLKKWESPAQNTAH--LDQFERIKTLGTGS FGRVMLVKHK--ETGNHYAMKIL-----DK-QKVV-KLKQI---EHTLNEKRIL-QAVNF PFLVKLE----FSF-----KDN--------SNLYMVMEYVPGGEMFS--HLRRIGRF--- SEPHARFYAAQI--VLTFEYLHSL-DLI--YRDLKPENLLID----QQGYIQVTDFGFAK RVKGR----TW---TLCGTPEYL-----------------------APEIIL-------- SKG---Y-NKAVDWWALGVLIYEMAAGYPPFF------ADQPIQIYE---KIV----SGK ---------------------VRFPSHF--------SSDLKDLLRNLLQVDLTKRFG--- ---------------------------NLKNGVNDIKNHKWF--------ATTDWI--AI YQRKVGLPSI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >T_rubripes_ENSTRUP00000013710 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MGNAPTARKG------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SEMESVKEFLAKAKEDFLKKWENPAQNTAC--LEQFERLKTLGTGS FGRVMLVKHR--ETGQHYAMKIL-----NK-QKVV-KLKQI---EHTLNEKRIL-QAVSF PFLVRLE----YSF-----KDN--------TNLYMVMEYVPGGEMFS--HLRRIGRF--- SEPHARFYAAQI--VLTFEYLHAL-DLI--YRDLKPENLLID----QQGYIQVTDFGFAK RVKGR----TW---TLCGTPEYL-----------------------APEIIL-------- SKG---Y-NKAVDWWALGVLVYEMAAGYPPFF------ADQPIQIYE---KIV----SGK ---------------------VRFPSHF--------SSDLKDLLRNLLQVDLTKRYG--- ---------------------------NLKNGVNDIKGHKWF--------ATTDWI--AI YQKKVEAPFI-------PKFKGPGDTSNFDDYE-------EEEIRVSFTEKCAKEFAEF- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >P_troglodytes_ENSPTRP00000018062 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------M--------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SNSSDVKEFLAKAKEDFLKKWESPAQNTAH--LDQFERIKTLGTGS FGRVMLVKHK--ETGNHYAMKIL-----DK-QKVV-KLKQI---EHTLNEKRIL-QAVNF PFLVKLE----FSF-----KDN--------SNLYMVMEYVPGGEMFS--HLRRIGRF--- SEPHARFYAAQI--VLTFEYLHSL-DLI--YRDLKPENLLID----QQGYIQVTDFGFAK RVKGR----TW---TLCGTPEYL-----------------------APEIIL-------- SKG---Y-NKAVDWWALGVLIYEMAAGYPPFF------ADQPIQIYE---KIV----SGK ---------------------VRFPSHF--------SSDLKDLLRNLLQVDLTKRFG--- ---------------------------NLKNGVNDIKNHKWF--------ATTDWI--AI YQRKVEAPFI-------PKFKGPGDTSNFDDYE-------EEEIRVSINEKCGKEFSEF- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >H_sapiens_ENSP00000309591 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MGNAAAAKKG------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SEQESVKEFLAKAKEDFLKKWESPAQNTAH--LDQFERIKTLGTGS FGRVMLVKHK--ETGNHYAMKIL-----DK-QKVV-KLKQI---EHTLNEKRIL-QAVNF PFLVKLE----FSF-----KDN--------SNLYMVMEYVPGGEMFS--HLRRIGRF--- SEPHARFYAAQI--VLTFEYLHSL-DLI--YRDLKPENLLID----QQGYIQVTDFGFAK RVKGR----TW---TLCGTPEYL-----------------------APEIIL-------- SKG---Y-NKAVDWWALGVLIYEMAAGYPPFF------ADQPIQIYE---KIV----SGK ---------------------VRFPSHF--------SSDLKDLLRNLLQVDLTKRFG--- ---------------------------NLKNGVNDIKNHKWF--------ATTDWI--AI YQRKVEAPFI-------PKFKGPGDTSNFDDYE-------EEEIRVSINEKCGKEFSEF- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >T_nigroviridis_ENSTNIP00000013350 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MGNTPTTKKG------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------NEMESVKEFLAKAKEDFLKKWENPAQQTAA--LDHFDRLKTLGTGS FGRVMLVKHK--ETGQHFAMKIL-----DK-QKVV-KLKQI---EHTLNEKRIL-QAVNF PFLVCLE----HSF-----KDN--------SNLYMVMEYVPGGEMFS--HLRRIGRF--- SEPHARFYAAQI--VLTFEYLHSL-DLI--YRDLKPENLLID----QQGYIQVTDFGFAK RVKGR----TW---TLCGTPEYL-----------------------APEIIL-------- SKG---Y-NKAVDWWALGVLIYEMAAGYPPFF------ADQPIQIYE---KIV----SGK ---------------------VRFPSHF--------SSDLKDLLRNLLQVDLTKRFG--- ---------------------------NLRNGVNDIKGHKWF--------ATTDWI--AI YQRKVEAPFI-------PKCKGPGDTSNFDDYD-------EEEIRVSFTEKCAKEFAEF- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >T_rubripes_ENSTRUP00000032222 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MCDRKSSRRHA------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------VCFSSECLVKEFLAKAKEDFLKKWENPAQQTAA--LDHFERLKTLGTGS FGRVMLVKHK--ESGQHFAMKIL-----DK-QKVV-KLKQI---EHTLNEKRIL-QAVNF PFLVCLE----HSF-----KDN--------SNLYMVMEYVPGGEMFS--HLRRIGRF--- SEPHARFYAAQI--VLTFEYLHSL-DLI--YRDLKPENLLID----QQGYIQVTDFGFAK RVKGR----TW---TLCGTPEYL-----------------------APEIIL-------- SKG---Y-NKAVDWWALGVLIYEMAAGYPPFF------ADQPIQIYE---KIV----SGK ---------------------VRFPSHF--------SSDLKDLLRNLLQVDLTKRFG--- ---------------------------NLRNGVNDIKGHKWF--------ATTDWI--AI YQRKVEAPFI-------PKCKGPGDTSNFDDYE-------EEEIRVSITEKCAKEFAEF- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >O_anatinus_ENSOANP00000000884 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------QVPVCFRRISREEAKTFPHTKQ--VGAYLVGKMINKGS FAKVMEGLHL--LTGEKVAIKVI-----DK-RKAQ-EDGYIL--ENMRREPRIQ-QMIKH PNIVQLY----ETL-----ETE--------NSYYMVMELCLGGDLLD--RIYNKQK---L EEEEVKKFTRQI--VSAVEHLHRH-GIV--HRDLKIENFLLD----ENSNIKIIDFGLSN ILKLEGLSQELLN-TQCGSPAYA-----------------------APELLA-------- HKK---Y-GPKVDVWSIGVSMFAMLTGTLPFTVD----PFNIKQLHQ---KMI----NGE V--------------------SSVPPGI--------SSGAVHFMHSLLEPDPGKRPA--- --------------------------------IKEAMKDKWLN-------EGFNRKPLSS ITYKNRFHPEDLNPLVLNYMADTMELSH------------TEIISVLISNRPSSIMASYS LLLKKLAKYHKEQ----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >M_mulatta_ENSMMUP00000025345 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MGANTSSKPPVFDENEDVNFDHFEILRAIGKGS FGKVCIVQKN--DTKKMYAMKYM-----NK-QKCVERNEV----RNVFKELQIM-QGLEH PFLVNLW----YSF-----QDE--------EDMFMVVDLLLGGDLRY--HLQQNVR---F KEETVKLFICEL--VMALDYLQSQ-RII--HRDMKPDNILLD----EHGHVHITDFNIAA MLPRE----TQIT-TMAGTKPYM-----------------------APEMFS-------- SRKGAGY-SFAVDWWSLGVTAYELLRGRRPYHIRS---STSSKEIVR---MFE----TTV ---------------------VTYPSAW--------SQEMASLLKKLLELNPDQRFS--- -------------------------------QLSDVQNFPYM--------NDINWD--AV FQKRLIPGFI--PNKGRLNCDPTFELEEMILESKPLHKKKKRLAKKEKDMRKCDSSQVNR SPPNSGSRVSP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >E_caballus_ENSECAP00000019558 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MNRYTTIKQLGDGT YGSVLLGRSI--ESGELIAIKKM-----KR-KFYS-WEE-----CMNLREVKSL-KKLNH ANVVKLK----EVI-----REN--------DHLYFIFEYMKE-NLYQ--LIKERNKL--F PESAIRNIMYQI--LQGLAFIHKH-GFF--HRDLKPENLLCM----GPELVKIADFGLAR EIRSR----PPYT-DYVSTRWYR-----------------------APEVLLR------- STN---Y-SSPIDIWAVGCIMAEVYT-LRPLFP-----GASEIDTIF---KICQVLGTPK KTDWPEGYQLSSAMNFRWPQCVPNNLKT---LIPNASSEAIQLLRDMLQWDPKKRPT--- --------------------------------ASQALRYPYFQIGHPLGSTTQSLQDSGK PQKEVLEKAG--PPPYMKPVPP--------AQP-------PNKPHTRISSRQHQASQPLQ HVLYPYKVEASRTDHA-HLPEDKPSPLLFPSLHT-------------------------- KNPQAKILTGLEHK---------------------------------------------- ----------------------------------NGEIKPKSRRRW-------------- G-----------------------------------------------------LVSRST KDSDDWADLDDLDFSPSLTRIDLKNKKRQS------------------------------ ----DETLCRQ--------VFESVLDLKPSEPVGTGNSAPTQTSYQRRDTPTLR-SAAKQ ------------LYLKHS---RYLPGINMRNGVLPNPGKDFIPSNPWS------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SSGVSGKSSGTVSVISKI---NSVGSGSASSRG LTGNYIPSFLKKE----------------------------------------------- ------------------------------------------------------------ ----IGSAMQRVHLAPI-----PDPSPGYSSLKAVRPHPGRPFFHTQPRST--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PGLMPRPPAAQPVHGRTDWAAKYASRR >A_aegypti_AAEL007931-PA MAGREQYQVKDRDDTMGLTIVFDSGIICHPYPGQYPGSLQGHPQHGTGPPPLHSKPNFSS SPLGQGPSTVPPSHTNHVHHQGMHGPSVTGQSGMATPQLDLGPSNPVPHHHHHHPNHMGG APGAASSHQHQPQQQQHLPPHNQQQHAMPPGSNGPMNGPGQFPGHHQPTIHHKMPSPASI TGSTAEPNVNSMNNNNPSTKANSRASSSSGGNISVAHSTTSSVQTGGA------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------SQQGGSGSTKAEQRLTHEQFRAALQMVVSAGDP--RENLENFTKIGEGS TGTVCIATDK--STGRQVAVKKM-----DL-RKQQ-RR------ELLFNEVVIM-RDYHH PNIVETY----SSF-----LVN--------DELWVVMEYLEGGALTD--IVTHSR----M DEEQIATVCKQC--LKALSYLHSQ-GVI--HRDIKSDSILLA----SDGRVKLSDFGFCA QVSQE---LPKRK-SLVGTPYWM-----------------------SPEVIS-------- RLP---Y-GPEVDIWSLGIMVIEMIDGEPPFF------NEPPLQAMR---RIR----DMP PPK------------------LKNSHKV--------SSRLQNFLDRMLVRDPVQRAT--- --------------------------------AAELLAHPFLR-------QAGPPSLLVP LMRGARHSNC-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >C_familiaris_ENSCAFP00000024262 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------SVKEFLAKAKEDFLKKWENPAQNTAH--LDQFERIKTLGTGS FGRVMLVKHK--ETGNHFAMKIL-----DK-QKVV-KLKQI---EHTLNEKRIL-QAVNF PFLVKLE----FSF-----KDN--------SNLYMVMEYVPGGEMFS--HLRRIGRF--- SEPHARFYAAQI--VLTFEYLHSL-DLI--YRDLKPENLLID----QQGYIQVTDFGFAK RVKGR----TW---TLCGTPEYL-----------------------APEIIL-------- SKG---Y-NKAVDWWALGVLIYEMAAGYPPFF------ADQPIQIYE---KIV----SGK ---------------------VRFPSHF--------SSDLKDLLRNLLQVDLTKRFG--- ---------------------------NLKNGVNDIKNHKWF--------ATTDWI--AI YQRKVEAPFI-------PKFKGPGDTSNFDDYE-------EEEIRVSINEKCGKEFTEF- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >G_aculeatus_ENSGACP00000013822 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MGNTPTAKKG------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------NEMESVKEFLAKAKEDFLKKWENPAQQTAA--LDHFERLKTLGTGS FGRVMLVKHK--ESGQHFAMKIL-----DK-QKVV-KLKQI---EHTLNEKRIL-QAVSF PFLVRLE----HSF-----KDN--------SNLYMIMEYVPGGEMFS--HLRRIGRF--- SEPHARFYAAQI--VLTFEYLHSL-DLI--YRDLKPENLLID----QQGYIQVTDFGFAK RVKGR----TW---TLCGTPEYL-----------------------APEIIL-------- SKG---Y-NKAVDWWALGVLIYEMAAGYPPFF------ADQPIQIYE---KIV----SGK ---------------------VRFPSHF--------SSDLKDLLRNLLQVDLTKRFG--- ---------------------------NLRNGVNDIKGHKWF--------ATTDWI--AI YQRKVEAPFI-------PKCKGPGDTSNFDDYE-------EEEIRVSFTEKCAKEFAEF- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------- >B_taurus_ENSBTAP00000020711 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MNRYTTIKQLGDGT YGSVLLGRSI--ESGELIAIKKM-----KR-KFYS-WEE-----CMNLREVKSL-KKLNH ANVVKLK----EVI-----REN--------DHLYFIFEYMKE-NLYQ--LIKERNKL--F PESAIRNIMYQI--LQGLAFIHKH-GFF--HRDLKPENLLCM----GPELVKIADFGLAR EIRSR----PPYT-DYVSTRWYR-----------------------APEVLLR------- STS---Y-SSPIDIWAVGCIMAEVYT-LRPLFP-----GASEIDTIF---KICQVLGTPK KTDWPEGYQLSNAMNFRWPQCVPNNLKT---LIPNASSEAVQLLRDMLQWDPKKRPT--- --------------------------------ASQALRYPYFQVGHPLGSTAHSLQESGK SQKDVLEKAA--APPHVKPVPP--------AQP-------PAKPHTRISSRQHQAGQPPQ HLMYPYKAEAPRTD---HLPEDKPSPLLLPSLHP-------------------------- KHPQAKILTGLEHK---------------------------------------------- ----------------------------------NGEIKPKSRRRW-------------- G-----------------------------------------------------LVSRST KDSDDWADLDDSDFSPSFTRIDLKN-KRQS------------------------------ ----DETLCR----------FESILDLKPSEPVGTGNSAPTQTSYPRRDTPTLR-SAAKQ ------------HYLKHS---RYLPGINIRNGVLPNPGKDFIPPNPWS------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SSGLSGKSSGTVSVISKI---TSVGSSSTSSSG LAGNYIPSFLKKE----------------------------------------------- ------------------------------------------------------------ ----ISSALQRVHLAPI-----PDPSPGYSSLKAVRPHPGRPFFHTQPRST--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PGLLPRPPAAQPVHGRTDWIAKYASRR >C_familiaris_ENSCAFP00000003279 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MNRYTTIKQLGDGT YGSVLLGRSI--ESGELIAIKKM-----KR-KFYS-WEE-----CMNLREVKSL-KKLNH ANVVKLK----EVI-----REN--------DHLYFIFEYMKE-NLYQ--LIKERNKL--F PESAIRNIMYQI--LQGLAFIHKH-GFF--HRDLKPENLLCM----GPELVKIADFGLAR EIRSR----PPYT-DYVSTRWYR-----------------------APEVLLR------- STN---Y-SSPIDIWAVGCIMAEVYT-LRPLFP-----GASEIDTIF---KICQLLGTPK KTDWPEGYQLSSAMNFRWPQCVPNNLKT---LIPNASSEAIQLLRDMLQWDPKKRPT--- --------------------------------ASQALRYPYFQIGHPLGSTTQSLQDSGK AQKDVLEKAG--PPPHIKPVPP--------AQP-------PTKPHPRISSRQHQGSQAPQ HLIYPYKAEASRTDHPNHLPEDKPSPLLFPSLHT-------------------------- KKPQSKMLAGLEPK---------------------------------------------- ----------------------------------NGEIKPKSRRRW-------------- G-----------------------------------------------------LVSRST KDSDDWADLDDLDFSPSLTRIDLKNKKRQS------------------------------ ----EETLCR----------FESVLDLKPSEPVGTGNSAPTQTSYQRRDTPTLR-SAAKQ ------------HYLKHS---RYLPGINIRNGILPNPGKDFIPSNPWS------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SSGLSGKSSGTVSCVTSFCFCESVGSGSTSSSG LTGNYIPSFLKKE----------------------------------------------- ------------------------------------------------------------ ----VGSAMQRVHLAPI-----PDPSPGYSSLKAVRPHPGRPFFHTQPRST--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PGLMPRPPAAQPVHGGTDWASKYASRR