10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000346921 ---------MAPSVP-A-----A------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000001820 ---------MAPSVP-A-----A------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000000068 ---------MAPSVP-A-----A------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000001575 ---------MAPSVP-A-----G------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000008266 ---------MAPSVP-A-----A------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000000870 ---------MAPSVP-A-----A------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000030583 ---------MAPNVL-A-----S------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000000134 ---------MAPNAL-A-----P------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000015279 ---------MAPNVP-A-----A------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000023406 ---------MAPNVP-A-----A------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000021331 ---------MAPNAP-A-----A------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000003389 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000021674 ---------MAPSVPVA-----P------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000038260 ---------MAPNAL-A-----P------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000057918 ---------MAPREA-A-----P------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000009354 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000010686 ---------MAPSTQ-E-----D------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000001375 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000002871 ---------MAPSTQ-L-----K------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000014271 ---------MAPSTQ-L-----K------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000002632 ---------MAPSAQ-L-----K------------------------------------------------------------------------------------------------- D_melanogaster_FBpp0072072 ---------MAPNAAVP-----V------------------------------------------------------------------------------------------------- A_aegypti_AAEL012731-PA ---------MAPNAAAV-----A------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000009260 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP007722-PA ---------MAPNAAEL-----K------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000005680 ----QSVAAMAPNAQ-AGGGRGQ------------------------------------------------------------------------------------------------- C_elegans_C29E4.8.1 MGVPKTQQSAQPATQ-S-----A------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000008001 ------------------------------------------------------------------------------------------------------------------------ S_cerevisiae_YDR226W ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000019202 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000013053 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000026774 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000020255 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000000191 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000021553 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000371230 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000022330 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000022789 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000013419 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000001303 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000025696 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000009832 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005329 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000035487 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000020744 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000075506 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023085 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000018438 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000003520 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000000302 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000016009 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000040941 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000012532 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001480 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000294419 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000001438 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000047505 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008631 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000001457 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0081807 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000001428 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000027460 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL000629-PA ------------------------------------------------------------------------------------------------------------------------ S_cerevisiae_YER170W MKADA------------------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000044000 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000016198 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000021273 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000009498 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000030252 SPARPARQRRRRPAGSGLSLAALLSTEVCVSPAARDGGGPLQLQAAATVGGSDSHREAPGELLPLCPRAGTGRGFPELRAWTGQQGRTRGWQASP------------------------- D_rerio_ENSDARP00000024387 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000015601 SPARPAGQRRRRPAGSGLSL-SLLSAEVCVSPAAWGGGGPLQLWAAATL-GMDSHREAAGELLPLCPRVGTGTGFPESHAWTGLQGRTRGWQASP------------------------- O_anatinus_ENSOANP00000002404 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000003062 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000009813 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000009214 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000023284 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000027683 ---------------------------------------------------------------PRCPKAGLWGGLKEGRRMEGREGGSKGERRGGGESP--------------------- T_guttata_ENSTGUP00000010324 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000008621 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK673.2.1 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000001087 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009660-PA ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000017952 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000068479 MG--CCVSSEPQEEGGR------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000014348 ------------------------------------------------------------------------------------------------------------------------ C_elegans_F38B2.4 MAPTVERKNINL------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000016776 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000029626 LLHAPSQLLISLKIKSTVPLFPLLCLFP-------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000022004 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000021914 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000008421 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000036580 MG--CCSSSDPRREDDL------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000021915 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000003665 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000017476 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000021101 CSSPPRQLHVCGRWRWFMLGSLLGNVS-------------RGAQSLL------------------------------------------------------------------------- M_mulatta_ENSMMUP00000018395 MG--CCSSSDPRREDDL------------------------------------------------------------------------------------------------------- C_elegans_F40F8.1.1 MH---------------------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000223836 MG--CCSSSDPRREDDL------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000029795 MG--ACCSRNHRNVEDS------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000050234 MG-ACCSGTDPRIMEDS------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000047632 MGSGCSRRSNSKTGPAK------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000005718 -----------------MFGRWVADVS-------------RKVPSLL------------------------------------------------------------------------- D_rerio_ENSDARP00000013777 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000010653 -----------------MVSRLVANVC-------------QKVPSLF------------------------------------------------------------------------- D_melanogaster_FBpp0075750 MLFMCHQRVMKKEAEEKLKAEEL------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000008856 MDATKKPLRIPPSFGVYAEEHGIFDMYKRLLCQLIIDKPVEPLQYLIDWLKRDNSNISKIAVIGPPASGKSGISKVMSKTINSVHITSDVLLDDELSDAANEAK--------KLISSSQA C_intestinalis_ENSCINP00000014265 MSLTPQQGQDYLIKHDIPQLIESIMIGLLHNRPNEPLNFISSCIESAKECGTKD-ISWHSFIPPPQLALEPILIPEKTGILSKNVFKTETPSRMLAEKKQPPPKLPPISSKKPTYEVEQ- E_caballus_ENSECAP00000006212 ---ACCSVTNPRDQEDS------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000008412 -----------------MIVGLLHRLS-------------EKLPRVL------------------------------------------------------------------------- D_rerio_ENSDARP00000043095 MDSAERPLRIPPEMVIYAEKHDIFHLIQTLVRNLMVDKPDDPIQYLINFLERDNVDVPRIILLGPPASGKRTVAKKLCEHTQAIHITFSDILKDD-SDLTRAAQ--------SYYDKKQN A_carolinensis_ENSACAP00000005788 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000360939 MLS------RCRSG---LLHVLGLSFLL------------QTRRPIL------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000001599 MLS------RYHSR---LLHVLGLSFLL------------QSRRPIL------------------------------------------------------------------------- M_mulatta_ENSMMUP00000022868 MLS------RCRSR---LLHVLGLSFLL------------QTRRPIL------------------------------------------------------------------------- E_caballus_ENSECAP00000014366 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000034708 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000010318 MLS------SCRRW---LLHVLVPSFP-------------PLTRGLR------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000001232 MLS------RCRSR---LLHVLGLSFLL------------QTRRPIL------------------------------------------------------------------------- A_aegypti_AAEL008131-PA MNSLNLFRRTLTTSIGGISRSSSSSSSPVSLIREFCPRRHLKAVPSNVKVDSSFGSAFGARTSSSWASVSSRSSAPSINRRILPVAIIGK------------------------------ G_gallus_ENSGALP00000017049 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000030491 MLS------SCRRL---LPHVLVPSCP-------------PLTRTLR------------------------------------------------------------------------- M_mulatta_ENSMMUP00000000192 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000008823 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000026582 MLN------RCGRR---LLHVLGLSFPL------------LTGRPLF------------------------------------------------------------------------- O_anatinus_ENSOANP00000008020 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000004772 AFTPLNYVRIC--QPWFMISRLVGNVS-------------QKLPNLF------------------------------------------------------------------------- M_musculus_ENSMUSP00000042785 MN--TNDAKEYLARRDIPQLFESLLNGLMCSKPEDPIEYLETCLQKVKELGGCDKVKWDTFVSQEKKTLPPLNGGQSRRSFLRNVMPENSNFPYRRYDRLPPIHQFSIESDTDLSETAEL O_latipes_ENSORLP00000020802 MDETVKPLRIPPQMRNYAEKHELTHLAQGLVSNLLIDQPDDPISYLIDLLQGSSLDTPRVMVLGPPAVGKYTLCKRLSAELQAVHVTTESLLQGQ-SELSALSE------KIKSSNANQD D_melanogaster_FBpp0084349 MWRALARTTLRAVANDCGSPGVGLAPSALTQHQLRHSKASNRFITTTSTAPPHN------------------------------------------------------------------ M_mulatta_ENSMMUP00000026618 MN--TNDAKEYLARREIPQLFESLLNGLMCSKPEDPVEYLESCLQKVKELGGCDKVKWDTFVSQEKKTLPPLNGGQSRRSFLRNVMPENSNFPYRRYDRLPPIHQFSIESDTDLSETAEL M_domestica_ENSMODP00000001785 MLS------CCLRL---RVSVPGLALPLPFLLPPSRAPGPRVRRLLLPTFDFS------------------------------------------------------------------- C_familiaris_ENSCAFP00000029454 MDATTAPHHIPPEMPQYGEERHVFELMQNMLEQLLIYQPKDPIPFMITHLQQDNDNVPKIVILGPPASGKTTIAMWLCKHLSSNLLTMDNLMAQKFSSLAAVAR--------EHYQKMKK C_elegans_C29F7.3 MY---------------------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000035667 HLSRLPAFCSLHLC---MVYRLLRTLP-------------RISAASF------------------------------------------------------------------------- M_mulatta_ENSMMUP00000009367 MLS------RCRSR---LLHVLGLSFLL------------QTRRPIL------------------------------------------------------------------------- E_caballus_ENSECAP00000004502 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000027551 MGLCKSKLPEVGRPLRP------------------------------------------------------------------------------------------------------- A_gambiae_AGAP009317-PA ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000008568 MLAIQTHLLNRSVCRLLV------------------------------------------------------------------------------------------------------ A_aegypti_AAEL009337-PA HESKQKEQAVSASAPQTPTC---------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000044291 MN--TNDAKEYLARREIPQLFESLLNGLMCSKPEDPVEYLESCLQKVKELGGCDKVKWDTFVSQEKKTLPPLNGGQSRRSFLRNVMPENSNFPYRRYDRLPPIHQFSIESDTDLSETAEL P_pygmaeus_ENSPPYP00000001422 MN--TNDAKEYLARREIPQLFEILLNGLMCSKPEDPVEYLESCLQKVKELGGCDKVKWDTFVSQEKKTLPPLNGGQSRRSFLRNVMPENSNFPYRRYDRLPPIHQFSIESDTDLSETAEL H_sapiens_ENSP00000346577 MN--TNDAKEYLARREIPQLFESLLNGLMCSKPEDPVEYLESCLQKVKELGGCDKVKWDTFVSQEKKTLPPLNGGQSRRSFLRNVMPENSNFPYRRYDRLPPIHQFSIESDTDLSETAEL M_mulatta_ENSMMUP00000031895 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010890 X---PNDAKDYLARR-IPQLFESLLNGLMCSKPEDPVEYLESCLQKVKELGGCDKVKWDTFVSQEKKTLPPLNGGQSRRSFLRNVMPENSNFPYRRYDRLPPIHQFSIESDTDLSETAEL A_gambiae_AGAP003968-PA VRNGSVPVCPFG------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000002369 MGRCQSKLPQVGKSLRP------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000034811 MDETDRPLRIPPQTFIYADKHNIFQLLQSLLSCLLIDQPDDPIDYLIRVLQRNPSGVSKVVLLGPPAVGKRTLARKLSADLQAAHVTCENLLESQ-PEQNIQTQTHTHTHTHTHTHTHKE A_carolinensis_ENSACAP00000002386 MDATSRPHRIPPAMGVYAEKHKVFQMMQNMTEALLIYRPKDPIEFMIEHLMKDNDEVPAVLVLGPPAAGKTTIARWLCKHLSATYLSPQQLLRNKLLRQSREAL--------ARQQLQGS 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000346921 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001820 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000000068 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001575 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000008266 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000000870 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000030583 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000000134 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000015279 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000023406 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000021331 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000003389 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000021674 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000038260 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000057918 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000009354 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000010686 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000001375 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000002871 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000014271 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000002632 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0072072 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL012731-PA ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000009260 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP007722-PA ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000005680 ------------------------------------------------------------------------------------------------------------------------ C_elegans_C29E4.8.1 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000008001 ------------------------------------------------------------------------------------------------------------------------ S_cerevisiae_YDR226W ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000019202 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000013053 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000026774 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000020255 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000000191 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000021553 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000371230 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000022330 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000022789 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000013419 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000001303 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000025696 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000009832 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005329 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000035487 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000020744 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000075506 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023085 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000018438 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000003520 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000000302 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000016009 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000040941 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000012532 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001480 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000294419 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000001438 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000047505 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008631 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000001457 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0081807 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000001428 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000027460 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL000629-PA ------------------------------------------------------------------------------------------------------------------------ S_cerevisiae_YER170W ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000044000 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000016198 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000021273 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000009498 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000030252 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000024387 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000015601 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002404 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000003062 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000009813 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000009214 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000023284 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000027683 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000010324 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000008621 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK673.2.1 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000001087 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009660-PA ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000017952 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000068479 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000014348 ------------------------------------------------------------------------------------------------------------------------ C_elegans_F38B2.4 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000016776 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000029626 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000022004 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000021914 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000008421 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000036580 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000021915 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000003665 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000017476 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000021101 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000018395 ------------------------------------------------------------------------------------------------------------------------ C_elegans_F40F8.1.1 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000223836 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000029795 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000050234 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000047632 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000005718 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000013777 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000010653 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0075750 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000008856 VTDKLWVQMIEERLKRKDC--LRRGFVLEGFPQNREQAIMLQANGLMLKHLVVLDAPNTVLVERQAGKRIDPTT-GDVYHTTFDWPQDSTVQARLLVPEG-ISETETRDRLNEYSRNIDG C_intestinalis_ENSCINP00000014265 ----------------------------------------------------------------------QPMMINKSEVQTEQH----------------------------------- E_caballus_ENSECAP00000006212 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008412 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000043095 VPKDLWIQLIQQHLSKPDC--VQRGWVLEAIPKTQDEALCLQEAGITPDHVVMLEAPDVVLIERSSGKRIDPVT-GDVYHVTFMWPESEEVARRLETPRTLMPVQVMSQKLQKYHTEAHA A_carolinensis_ENSACAP00000005788 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000360939 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001599 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000022868 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000014366 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000034708 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000010318 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000001232 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL008131-PA ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000017049 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000030491 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000000192 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000008823 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000026582 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008020 -PQTLLLPLISRKPKEAEA--VQKGWIVDGFPETREQAILLQIIGIFPRHVVILHAPDTVLIERNLGKRIDPYS-GEVYHTTFDWPAEPEIQERLVMAEG-ISEEETSRKLLEYHRNISR T_rubripes_ENSTRUP00000004772 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000042785 IEEYEVFDPTRPRPKIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSASSNRKWSLIAKIITNGELAPQETTITEIKQKLMQIPDEEGIVIDGFPRDVAQALSFEDQICTPD O_latipes_ENSORLP00000020802 LPSELLVRILQQRLKEVDCLFVWQGWVLQGIPKTRLQALNLQQVGVLPKHVVMLEAPDDVLQERNQGRMVDPQTKADTYHQILNWPSDDTIAGRLQKGRS-LSNEQLSEELQHHSCEVSG D_melanogaster_FBpp0084349 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000026618 IEEYEVFDPTRPRPKIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKWSLIAKIITTGELAPQETTITEIKQKLMQIPDEEGIVIDGFPRDVAQALSFEDQICTPD M_domestica_ENSMODP00000001785 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000029454 LSNTLLVRLIQERLREEDC--IRRGWILDGIPATREQALMIQTIGITPRHVIALSAPDTVLIERNLGKRIDPQT-GEIYHTTFDWPPESEIQNRLVVPGG-ISELETAQKLLEYHRNIIR C_elegans_C29F7.3 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035667 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000009367 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000004502 ------------------------GWILDGIPETREQALMIQTVGITPRHVIVLSAPDTVLIERNLGKRIDPQT-GEIYHTTFDWPSESEIQDRLIVPVG-ISELETAGKLLEYHRNIVR C_familiaris_ENSCAFP00000027551 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009317-PA ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000008568 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL009337-PA ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000044291 IEEYEVFDPTRPRPKIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKWSLIAKIITTGELAPQETTITEIKQKLMQIPDEEGIVIDGFPRDVAQALSFEDQICTPD P_pygmaeus_ENSPPYP00000001422 IEEYEVFDPTRPRPKIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKWSLIAKIITTGELAPQETTITEIKQKLMQIPDEEGIVIDGFPRDVAQALSFEDQICTPD H_sapiens_ENSP00000346577 IEEYEVFDPTRPRPKIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKWSLIAKIITTGELAPQETTITEIKQKLMQIPDEEGIVIDGFPRDVAQALSFEDQICTPD M_mulatta_ENSMMUP00000031895 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010890 IEEYEVFDPTRPRPKIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSASSNRKWSLIAKIITTGELAPQETTITEIKQKLMQIPDEEGIVIDGFPRDVAQALSFEDQICTPD A_gambiae_AGAP003968-PA ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000002369 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000034811 LPVELLVKRIQQRLNDCN---ITQGWLLEGFPQTRLQALCLQEAGIIPEHVVVLEAPDDVLLQRSRGKMVDPLT-GEVYHQTFLWPDDHTVAQRL-RHEE-LSDKQHVAELQRYRCEGQG A_carolinensis_ENSACAP00000002386 VPDELWAGLLEERLADVDC--VKLGWVLDGFPETRAQARLLQALGVAPRHVVVLEAPEMVLVERNLGKRVDPLT-QEVYHTTFDWPIDFTVQKRLVKPEG-TSVQDTAKRLLESHRNIPG 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000346921 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001820 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000000068 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001575 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000008266 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000000870 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000030583 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000000134 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000015279 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000023406 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000021331 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000003389 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000021674 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000038260 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000057918 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000009354 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000010686 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000001375 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000002871 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000014271 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000002632 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0072072 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL012731-PA ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000009260 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP007722-PA ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000005680 ------------------------------------------------------------------------------------------------------------------------ C_elegans_C29E4.8.1 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000008001 ------------------------------------------------------------------------------------------------------------------------ S_cerevisiae_YDR226W ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000019202 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000013053 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000026774 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000020255 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000000191 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000021553 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000371230 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000022330 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000022789 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000013419 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000001303 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000025696 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000009832 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005329 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000035487 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000020744 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000075506 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023085 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000018438 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000003520 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000000302 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000016009 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000040941 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000012532 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001480 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000294419 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000001438 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000047505 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008631 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000001457 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0081807 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000001428 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000027460 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL000629-PA ------------------------------------------------------------------------------------------------------------------------ S_cerevisiae_YER170W ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000044000 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000016198 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000021273 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000009498 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000030252 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000024387 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000015601 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002404 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000003062 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000009813 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000009214 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000023284 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000027683 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000010324 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000008621 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK673.2.1 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000001087 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009660-PA ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000017952 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000068479 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000014348 ------------------------------------------------------------------------------------------------------------------------ C_elegans_F38B2.4 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000016776 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000029626 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000022004 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000021914 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000008421 ----------------------------