>H_sapiens_ENSP00000353059 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MDAKARNCLLQHREALEKDIKTSYIMDH MISDGFLTISEEEK---------------------------------------------V RNEPT-------------------------------QQQRAAMLIKMILKKDN------- ---------D---SY--VSFYNALLHEGYKDLAALLHDGIPV--VSSSS-GKDSVSGITS Y-------------VRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGM AGCGKSVLAAEAVRDHSLLE-GCFPGGVHW-VSVGKQDKSGLLMKLQNLCTRLDQ--DES FSQRLP-LNIEEAKDRLRILMLRKH-P--RSLLILDDVWDSWVLKAFDSQCQILLTTRDK SVTDSVM-GPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSL IGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDL SILQKDVKVPTKVLCILWDMETEEVEDILQE----------------------------- ----------FVNKSLLFCDRNGKSFRYYLHDLQV---------DFLTEKNCSQLQDLHK KIITQFQRYHQPHTLSPDQED----------------------CMYWYNFLAYHMASAKM HKELCAL-MFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKD----CAVSENFQEFLSLN GHLLGRQPFPNIVQL-----------GLCEPETSEVYQQ-AKLQAKQEVDNGMLYLEWIN KKNITNLSRL-----VVRP-----HTDAVYHACFSEDGQRIASCGAD---KTLQVFKAE- TGEKLLEIKA-HEDEVLCCAFS--TDDRFIATCSVDKKVKIWNSMTGELVHTYDE-HSEQ VNCCHFTN-SSH-HLLLATGSSDCF--LK----LWDLNQKECRNTMFGHTNSVN--HCRF ------SPDDKLLASCSADGTLKLWDATS--ANE-------------------------- -----------------RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK I----------------------------------------------------------- -------------FLFDIHTSGLLGEI-HTGHHSTIQYCDFSPQNHLAVVALSQYCVELW NTDSRS---------K------------VAD----------------------------- --CRGHLSWVHGVMFSPDGSSFLTSS-DDQTIRLWE-TKKVCKNSAVMLKQEVDVVFQEN EVMVLAVDHIRRL-QLINGRTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILE LVNN----RIFQSRFQHKKTVWHIQF----TADEKTL-ISSSDDAEIQV-WNW----QLD KCIFLRGHQETVKDFRLLKNS----RLLSWSFD---GTV-KVWNIIT--GNKEKDFVCHQ G-TVLSCDIS----HDAT-----KFSSTSADK----TAKIWSFD---LLLPLH-ELRGHN GCVRCSAFSVD-STLLATGDDN-GEIRIWNVSNGELLHLCAPLS-EEGAATHGGWVTDLC FSPDGKMLISAG--GYIK--WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGI LYI--------------------LQTLE-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >P_troglodytes_ENSPTRP00000042795 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MDAKARNCLLQHREALEKDIKTSYIMDH MISDGFLTISEEEK---------------------------------------------V RNEPT-------------------------------QQQRAAMLIKMILKKDN------- ---------D---SY--VSFYNALLHEGYKDLAALLHDGIPV--VSSSS-GKDSVSGITS Y-------------VRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGM AGCGKSVLAAEAVRDHSLLE-GCFPGGVHW-VSVGKQDKSGLLMKLQNLCTRLDQ--DES FSQRLP-LNIEEAKDRLRILMLRKH-P--RSLLILDDVWDSWVLKAFDNQCQILLTTRDK SVTDSVM-GPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSL IGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDL SILQKDVKVPTKVLCILWDMETEEVEDILQE----------------------------- ----------FVNKSLLFCDRNGKSFRYYLHDLQV---------DFLTEKNCSQLQDLHK KIITQFQRYHQPHTLSPDQED----------------------CMYWYNFLAYHMASAKM HKELCAL-MFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKD----CAVSENFQEFLSLN GHLLGRQPFPNIVQL-----------GLCEPETSEVYQQ-AKLQAKQEVDNGMLYLEWIN KKNITNLSRL-----VVRP-----HTDAVYHACFSEDGQRIASCGAD---KTLQVFKAE- TGEKLLEIKA-HEDEVLCCAFS--TDDRFIATCSVDKKVKIWNSMTGELVHTYDE-HSEQ VNCCHFTN-SSH-HLLLATGSSDCF--LK----LWDLNQKECRNTMFGHTNSVN--HCRF ------SPDDKLLASCSADGTLKLWDATS--ANE-------------------------- -----------------RKSINVKQFFLNSEDPQEDMEVIVKCCSWSADGARIIVAAKNK I----------------------------------------------------------- -------------FLFDIHTSGLLGEI-HTGHHSTIRYCDFSPQNHLAVVALSQYCVELW NIDSRS---------K------------VAD----------------------------- --CRGHLSWVHGVMFSPDGSSFLTSS-DDQTIRLWE-TKKVCKNSAVMLKQEVDVVFQEN EVMVLAVDHIRRL-QLINGRTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILE LVNN----RIFQSRFQHRKTVWHIQF----TADEKTL-ISSSDDSEIQV-WNW----QLD KCIFLRGHQETVKDFRLLKNS----RLLSWSFD---GTV-KVWNIIT--GNKEKDFVCHQ G-TVLSCDIS----HDAT-----KFSSTSADK----TAKIWSFD---LLLPLH-ELRGHN GCVRCSAFSVD-STLLATGDDN-GEIRIWNVSNGELLHLCAPLS-EEGAATHGGWVTDLC FSPDGKMLISAG--GYIK--WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGI LYI--------------------LQTLE-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >P_pygmaeus_ENSPPYP00000005543 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MDAKARNCLLQHREALEKDIKTSYIMDH MISDGFLTISEEEK---------------------------------------------V RNEPT-------------------------------QQQRAAMLIKMILKKDN------- ---------D---SY--ISFYNALLHEGYKDLAALLHDGIPV--VSSSS-GKDSVSGITS Y-------------VRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGM AGCGKSVLAAEAVRDHSLLE-GCFPGGVHW-VSVGKQDKSGLLMKLQNLCTRLDQ--DES FSQRLP-LNIEEAKDRLRILMLRKH-P--RSLLILDDVWDSWVLKAFDNQCQILLTTRDK SVTDSVM-GPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSL IGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDL SILQKDVKVPTKVLCILWDMETEEVEDILQE----------------------------- ----------FVNKSLLFCDRNGKSFRYYLHDLQV---------DFLTEKNCSQLQDLHK KIITQFQRYHQSHTLSPDQED----------------------CMYWYNFLAYHMASAKM HKELCAL-MFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKD----CAVSENFQEFLSLN GHLLGRQPFPNIVQL-----------GLCEPETSEVYQQ-AKLQAKQEVDNGMLYLEWIN KKNITNLSRL-----VVRP-----HTDAVYHACFSEDGQRIASCGAD---KTLQVFKAE- TGEKLLEIKA-HEDEVLCCAFS--TDDRFIATCSVDKKVKIWNSMTGELVHTYDE-HSEQ VNCCHFTN-SSH-HLLLATGSSDCF--LK----LWDLNQKECRNTMFGHTNSVN--HCRF ------SPDDKLLASCSADGTLKLWDVTS--ANE-------------------------- -----------------RKSINVKQFFLNSEDPQEDMEVIVKCCSWSADGARIMVAAKNK I----------------------------------------------------------- -------------FLFDIHTSGLLGEI-HTGHHSTIQYCDFSPQNHLAVVALSQYCVELW NIDSRS---------K------------VAD----------------------------- --CRGHLSWVHGVMFSPDGSSFLTSS-DDQTIRLWE-TKKVCKNSAVMLKQEVDVVFQEN EVMVLAVDHIKRL-QLINGKTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILE LVNN----RIFQSRFQHKKTVWHIQF----TADEKTL-ISSSDDSEIQV-WNW----QLD KYIFLRGHQETVKDFRLLKNS----RLLSWSFD---GTV-KVWNIIT--GNTEKDFVCHQ G-TVLSCDIS----HDAT-----KFSSTSADK----TAKIWSFD---HLLPLH-ELRGHN GCVRCSAFSVD-STLLATGDDN-GEIRIWNVSNGELLHLCAPLS-EEGAATHGGWVTDLC FSPDGKMLISAG--GYIK--WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGI LYI--------------------LQTLE-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >M_mulatta_ENSMMUP00000038848 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MDAKARNCLLQHREALEKDIKTSYIMNH MIRDGFLTISEKEK---------------------------------------------V KNEPT-------------------------------HHQRAAMLIKMILKKDN------- ---------D---SY--ISFYNALLHEGYKDLAALLHDGIPV--VSSSS-GKDSVSGITS Y-------------VRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGM AGCGKSVLAAEAVRDHSLLE-DCFPGGVHW-VSVGKQDKSGLLMKLQNLCTRLDQ--DES FSQRLP-LNIEEAKDRLRILMLRKH-P--RSLLILDDVWDSWVLKAFDNQCQILLTTRDK SVTDSVM-GPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSL IGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKYYYTDL SILQKDVKVPTKVLCILWDMETEEVEDILQE----------------------------- ----------FVNKSLLFCDRNGKSFRYYLHDLQV---------DFLTEKNCSQLQDLHK KIITQFQRYHQPHTLSPDQED----------------------CMYWYNFLAYHMASAKM HKELCAL-MFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKD----CAVSENFQEFLSLN GHLLERQPFPNIVQL-----------GLCEPETSEVYQQ-AKLQAKQEVDNGMLYLEWIN KKNITNLSRL-----VVRP-----HTDAVYHACFSEDGQRIASCGAD---KTLQVFKAE- TGEKLLEIKA-HEDEVLCCAFS--TDDRFIATCSVDKKVKIWNSVTGELVHTYDE-HSEQ VNCCHFTN-SSH-HLLLATGSSDCF--LK----LWDLNQKECRNTMFGHTNSVN--HCRF ------SPDDKLLASCSADGTLKLWDVTS--ANE-------------------------- -----------------RKSFNVKQFFLNSEDPQEDMEVIVKCCSWFADGARIMVAAKNK I----------------------------------------------------------- -------------FLFDIHTSGLLGEI-HTGHHSTIQYCDFSPQNHLAVVALSQYCVELW NIDSCS---------K------------VAD----------------------------- --CRGHLSWVHGVKFSPDGSSFLTSS-DDQTIRLWE-TKKVCKNSAIMLKQEVDVVFQEN EVMVLAVDHIRRL-QLINGKTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGTIEILE LVNN----RIFQSRIRHKKTVWHIQF----TADEKTL-ISSSDDSAIQV-WNW----QLE EYVFLQAHQETVKDFRLLKNS----RLLSWSFD---GTV-KVWNIIT--GKIEKDFVCHQ G-TVLSCDIS----HDAT-----KFSSTSADK----TAKIWSFD---LLLPLH-ELRGHN GCVRCSAFSVD-STLLATGDDN-GEIRIWNVSNGELLHLCAPLS-EEGAATHGGWVTDLC FSPDGKMLISAG--GYIK--WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGI LYI--------------------LQTLE-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >E_caballus_ENSECAP00000022364 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------RMDAKARNCLLQHREALEKDIKTSYIMDY MISDGVLTVSEEEK---------------------------------------------V KNEPT-------------------------------RQQKAAMLIKMILKKDN------- ---------Y---CY--ISFYKALLQEGYKDLAALLHGGIPV--LSSSN-GKDSLVGVTS Y-------------VKTVLCEGGVPQRPVVFVTRKKLVHAIRQKLLKLDGEPGWVTIYGM AGCGKSVLAAEAVRDHTLLE-GCFPGGVHW-LSVGKQDKSGLLMKLQNLCTRLDQ--DES FSQRLP-LNIEEAKDRLRILMLRKH-P--RSLLILDDVWDPWVLKAFDNQCQILLTTRDR SVTDSVM-GPKYVIPVESGLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSL IGALLRDFPNRWEYYLRQLQNKQFKRIRKCSSYDYEALDEAMSISVEMLREDIKDYYTDL SILQKDVKVPTKVLCILWDMETEEVEDILQE----------------------------- ----------FVNKSLLFCDRNGKSFRYYLHDLQV---------DFLTEKNRSQLQDLHR KIITQFQRHHRLHTLSPDQED----------------------CMYWYNFLAYHMASANM HKELCAL-MFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKD----CSVCENFQEFLSLN GHLLGRQPFPNIVQL-----------GLCEPETSEVYQQ-AKLQAKQEVDNGMLYLEWIN KKNIKNLSRL-----VVRP-----HTDAVYHACFSGDGQRIASCGAD---KTLQVFKAE- TGEKLLEIKA-HEDEVLCCAFS--TDDRFIATCSVDKKVKIWNSMTGELVHTYDE-HSEQ VNCCHFTN-NSH-HLLLATGSSDSF--LK----LWDLNEKDCRNTMFGHTNSVN--HCRF ------SPDDKLLASCSADGSLKLWDVKS--ANE-------------------------- -----------------RKSINVKQFFISSEEPQEDMEVIVKCCSWSSDGARIMVAAKNK I----------------------------------------------------------- -------------FLVDVHTCGLLAEI-HTGHHSTIQYCDFSPSNHLAVVALSQYCVELW NMDSCL---------K------------VAD----------------------------- --CRGHLSWVHSVMFSPDGSSFLTSS-DDETIRLWE-TKKVCKNSGIVLKQEIDVLFQEN EVMILAVDNMRRL-QLINGKTGQIDYLTEAQ---VSSCCLSPHLQYVALGGEDGAIKILE LLNN----RIFQSKIGHKSAVRHVQF----TTDGKTL-ISSSDDSVIQV-WNW----QSE EYVFLQAHQEAVKDFRLLRNS----RLLSWSFD---GTV-KVWNIIT--GRIEKDFVCHQ D-TVLSCDIS----PDAT-----KFSSTSADK----TAKIWSFE---LLSPLH-ELRGHK GCVRCSVFSGD-STLLATGDDN-GEIRIWSVSNGELLHLCAPISVEEGAATHGGWVTDLC FSPDSKMLVSAE--GSLK--WWNAVTGESAQTFYTNGTNLKKIHVSPDFKTYVTVDNLGI LYI--------------------LQVLE-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >B_taurus_ENSBTAP00000028867 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------GKMDAKARNCLLQHREALERDIKTSYIMDH MISNGVLTVSEEEK---------------------------------------------V KNEPT-------------------------------QRQRAAMLIKMILKKDN------- ---------H---SY--ISFYNALLHEGYKDLAALLHGGIPV--ISSSD-GKDSVSGITS Y-------------VRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLNGEPGWVTIYGM AGCGKSVLAAEAVRDHSFLE-DCFPGGVHW-VSVGKQDKSGLLMKLQNLCARLDQ--DES FSQRLP-LNIEEAKDRLRILMLRKH-P--RSLLILDDIWDPWVLKAFDNQCQILLTTRDK SVTDSVM-GPKYVVPVESGLGKEKGLEILSLFVNMKKADLPEQAHSIIQECKGSPLVVSL IGALLRDFPNRWEYYLRQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDL SILQKDVKVPTKVLCILWDLETEEVEDILQE----------------------------- ----------FVNKSLLFCDRNGKSFLYYLHDLQV---------DFLAEKNRSQLQDLHK KMVTQFQRHHQLYSLSPDQED----------------------CMYWYSFLAYHMASANM HKELCAL-MFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKD----GIDCENFQEFLSLN GHLLGRQPFPNIVQL-----------GLCELETSEVYRQ-AKLQAKQEVDNGMLYLEWVN KKNMKNLSRL-----VVRP-----HTDAVYHACFSEDGQRIASCGAD---KTLQVFKAE- TGEKLLEIKA-HEDEVLCCAFS--ADDKFIATCSVDKKVKIWNSMTGELVRIYDE-HSEQ VNCCHFTN-NSN-HLLLATGSNDYF--LK----LWDLNQEECRNTMFGH-NSVS--HCRF ------SPDDQVLASCSADGTLKLWDVKS--ANE-------------------------- -----------------RKSINVKQFFLNSEEPQEDLEVIVKCCSWSADGAKIMVAAKNK V----------------------------------------------------------- -------------FLFDIHSSGLLAEM-HMGHHSAVQYCDFSPHNHLAVVALSQYCVELW SMDSGL---------K------------VAD----------------------------- --CRGHLSWVHCVMFSPDGSSFLTSS-DDQTIRLWE-TKKVCKNSATVLKQEIDVVFQEN EVTVLAVDNIRRL-QLINGNTGQIDYLTEAQ---VSCCCLSPHLQYLAFGGEDGAIQILE LLNN----RIFQSRNGHKTTVRHIQF----TADGKTL-ISSSDDSAVQI-WNW----QSE DPFFLQAHQETVKDFRLLKNS----RLLSWSFD---GTV-KVWNIIT--RRIEKDFVCHQ D-TVLSCDIS----SDAT-----KFSSTSADK----TAKIWSFE---LLSPLH-ELRGHK GCVRCSSFSVN-NTLLATGDDN-GEIRIWNVSNGELLHLCAPISVEEGAATHGGWVTDLC FSPDTKMLVSAG--GYLK--WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGI LYI--------------------LKILE-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >C_familiaris_ENSCAFP00000009806 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------GRMDAKARNCLLQYREALEKDIKTSYIMDR MINDGVLTISEEEK---------------------------------------------V KNEPT-------------------------------QQQRAALLIKTILKKDN------- ---------Y---SY--ISFYNALIHEGYKDLAALLHSGIPV--ISSSNGGKDSVGGITS H-------------VKTVLCEGGVPQRPVVFVTRKKLVNAIRQNLFKLSDEPGWVVIYGM AGCGKSVLAAEAVRDHFFLDVGCFPGGVHW-VSVGKQDKAGLLMKLQNLCTRLDQ--DEN FSQRPP-LNIEEAKDRLRLLMLRKH-PRIRSLLILDDIWDSWILKAFDNQCQILLTTRDK SVTDSVM-GPKYIVAVESDLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSL IGALLRDFPNRWDYYLRQLQNKQFKRIRKSSFYDYEALDEAMSISVEMLREDIKDYYTDL SILQKDVKVPTKVLCILWDMETEEVEDILQE----------------------------- ----------FVNKSLLFCDRNGKSFRYYLHDLQV---------DFLIEKNRNQLQDLHK KIVTQFQKHYQPHTLSPDQED----------------------CMYWYNFLAYHMASASM HKELCAL-MFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKD----CAVCENFQEFLSLN GHLLGRQPFPNIVQL-----------GLCEPETSEVYQQ-AKLQAKQEVDHGMLYLEWIN KKNIKNLSRL-----VVRP-----HTDAVYHACFSEDGQRIASCGVD---KTLQVFKAE- TGEKLLEIKA-HEDEVLCCAFS--TDDRFIATCSVDKKVKIWNSMTGGLVHVYDE-HSEQ VNCCHFTN-NSH-YLLLATASSDCF--LK----LWDLNQKECRNTMFGHTNSVN--HCRF ------SPDDKLLASCSADGTLKLWDVKS--ANE-------------------------- -----------------RKSINVKQFFLNSEEPQEDMEVIVKCCSWSADGTRIMVAAKNK I----------------------------------------------------------- -------------FLFDIHTGGLLAEI-HTGHHSTIQYCDFSPQNHLAVVALSQCCVELW NMDSCL---------K------------VAD----------------------------- --CRGHLSWVHCVMFSPDGSSFLTSS-DDQTIRLWE-TKKVCKNSAIVLKQEIDVVFQEN EVMVLAVDNIKRL-QLINGKTGQIDYLIEAQ---VSCCCLSPHLQYIAFGGEDGAVEILE LLNN----RIFQSRIGHKKTVRHIQF----TDDGKTL-ISSSDDSSIQV-WNW----QSE EYVFLQAHQETVKDFKLLKNS----KLLSWSFD---GTVKKIWSIIT--GRIEKDFVCHQ D-TVLSCDIS----PDAT-----KFSSTSADK----TAKIWSFE---LLSPLH-ELRGHK GCVRCSVFSVD-STLLATGDDN-GEIRIWNVSNGELLHLCAPILVEEGAATHGGWVTDLC FSPDSKMLVSAG--GYLK--WWNVVTGESSQTFYTNGTCLKKIHVSSDFKTYVTVDNLGI LYI--------------------LQMLE-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >M_musculus_ENSMUSP00000020157 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MDAKARNCLLQHREALEKDIKTSYIMDH MISNGVLSVIEEEK---------------------------------------------V KSQAT-------------------------------QYQRAAALIKMILNKDN------- ---------C---AY--ISFYNALLHEGYKDLAALLQSGLPL--VSSSS-GKDTDGGITS F-------------VRTVLCEGGVPQRPVIFVTRKKLVHAIQQKLWKLNGEPGWVTIYGM AGCGKSVLAAEAVRDHSLLE-GCFSGGVHW-VSIGKQDKSGLLMKLQNLCMRLDQ--EES FSQRLP-LNIEEAKDRLRVLMLRKH-P--RSLLILDDVWDPWVLKAFDNQCQILLTTRDK SVTDSVM-GPKHVVPVESGLGREKGLEILSLFVNMKKEDLPAEAHSIIKECKGSPLVVSL IGALLRDFPNRWAYYLRQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDL SILQKDVKVPTKVLCVLWDLETEEVEDILQE----------------------------- ----------FVNKSLLFCNRNGKSFCYYLHDLQV---------DFLTEKNRSQLQDLHR KMVTQFQRYYQPHTLSPDQED----------------------CMYWYNFLAYHMASANM HKELCAL-MFSLDWIKAKTELVGPAHLIHEFVAYRHILDEKD----CAVCENFQEFLSLN GHLLGRQPFPNIVQL-----------GLCEPETSEVYRQ-AKLQAKQEGDTGRLYLEWIN KKTIKNLSRL-----VVRP-----HTDAVYHACFSQDGQRIASCGAD---KTLQVFKAE- TGEKLLDIKA-HEDEVLCCAFS--SDDSYIATCSADKKVKIWDSATGKLVHTYDE-HSEQ VNCCHFTN-KSN-HLLLATGSNDFF--LK----LWDLNQKECRNTMFGHTNSVN--HCRF ------SPDDELLASCSADGTLRLWDVRS--ANE-------------------------- -----------------RKSINVKRFFLSSEDPPEDVEVIVKCCSWSADGDKIIVAAKNK V----------------------------------------------------------- -------------LLFDIHTSGLLAEI-HTGHHSTIQYCDFSPYDHLAVIALSQYCVELW NIDSRL---------K------------VAD----------------------------- --CRGHLSWVHGVMFSPDGSSFLTAS-DDQTIRVWE-TKKVCKNSAIVLKQEIDVVFQEN ETMVLAVDNIRGL-QLIAGKTGQIDYLPEAQ---VSCCCLSPHLEYVAFGDEDGAIKIIE LPNN----RVFSSGVGHKKAVRHIQF----TADGKTL-ISSSEDSVIQV-WNW----QTG DYVFLQAHQETVKDFRLLQDS----RLLSWSFD---GTV-KVWNVIT--GRIERDFTCHQ G-TVLSCAIS----SDAT-----KFSSTSADK----TAKIWSFD---LLSPLH-ELKGHN GCVRCSAFSLD-GILLATGDDN-GEIRIWNVSDGQLLHSCAPISVEEGTATHGGWVTDVC FSPDSKTLVSAG--GYLK--WWNVATGDSSQTFYTNGTNLKKIHVSPDFRTYVTVDNLGI LYI--------------------LQVLE-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >O_anatinus_ENSOANP00000008896 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------GRMDARARNCLLKHMEALEKDIKTSYIMDH MISDRTLTLSEEEK---------------------------------------------V RNQGT-------------------------------QEERAAMLIKLILEKDN------- ---------F---SY--ISFYNALLHEGYRDLAALLQDGIPF--TASPK-GNDSLDGVTS Y-------------VRTVLCEGGVPQRPVVFVTRKKLVNEIQQKLYRLNDEPGWVTVYGM AGCGKSVLAAEALRDHRLLV-DCFPGGVHW-ISIGKQDKAGLLMKLQNLCMRFDQ--GSN FSQRPP-LNIEEAKDRLRVLMLRKY-P--RSLLILDDVWDSWVLKAFDIQCQVLLTSRDK SVTDSVMVGQKYVVPVESGLGKEKGLEILSLFVNMKKTDLPEQAHSIVQECKGSPLVVSL IGALLRDFPNRWEYYLRQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLTEEFKDYYKDL SVLQKDVKVPTKVICILWEMETEEVEDILQE----------------------------- ----------FVNKSLLFCDRNGKTFHYYLHDLQV---------DFLTEKNRSQLQELHK KIVNQYQKYYQLRTLSPDQDD----------------------CMYWYNFLAYHMASANM HKELCAL-MFSLDWIKSKTELVGPAHLIHEFAEYSHILDEKD----CTVCENFQEFLSLN GHLLGRQPFPNIVQL-----------GLCEPETSEVYRQ-AKLRAKQEVDKGMLYLEWIN KKNIKNLSRL-----VVRP-----HTDAVYHACFSEDGQRIASCGAD---KTVQVFKAE- TGEKLLEIKA-HEDEVLCCAFS--PDDKFVATCSTDKKVKVWNSQTGKLVHTYEE-HTEQ VNFCQFSN-TSS-HPLLATCSNDQF--LK----LWDLNQKGCRNTMFGHSDSVN--HCKF ------SPDDKYLASCSADGTLKLWEVAS--ANE-------------------------- -----------------WKSIDVSKFFQTSEH-EEDVEVLVKCCSWTTDGATIMVTAKNM I----------------------------------------------------------- -------------FLFDVKTSGLSAEI-QTSHHSTIQYCDFYPCSHLAVVALSHYCVELW NTDSCL---------K------------VAD----------------------------- --CRGHLSWVHCVTFSPDGSSFLTSS-DDQTIRVWD-TSKVCKNSAVMLKQEIDVVFRDN EVMVLAVDSLRHL-QLINGKTGQTDYLTEAQESLICCCCLSPTLISLAFGEEDGTVKILE LPNG----RMFKSKIKHKKPVQHCRF----TSDGKTV-ISSSDDPVIQV-WIW----QTE EYVFLQAHQESVKDFRLLQNS----RLFSWSFD---GTI-KVWNILT--GKVEKDFFCHQ G-AVLSCNIS----PDAT-----KFSSTSADK----TAKIWSFE---NSSLLH-ELSGHE GCVRCSAFSDD-SSLLATGDDN-GEIRIWDVSKGEILHLCAPGPVGE-ASTHGGWVTDLC FSPDSKILVSAG--GFLK--WWNMDTGESLQTFYTNGTNLKTIFVSPSFKSYVTVDNLGI LYV--------------------LQMLE-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >M_domestica_ENSMODP00000009538 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------RMDAKARNCLLQHKEALERDIKTSYLMDH MISDQVLSLSEEEK---------------------------------------------I RNEPT-------------------------------QKKRAALLITVLLGKDN------- ---------N---SY--ISFYNALLHEGYKDLAFLLQKGLPL---SSYN-GKDPVDGVTS Y-------------VKTVLCEGGVPQRPVVFVTRKKLVKSIQEKLYKLNDEPGWVTVYGM AGCGKSVLAAEAVRDHNLLK-TCFPEGVHW-VSVGQQDKSGLLMKLQNLCTRLDQ--DGA FSQRLP-LNLEEAKDRLRFLMLRKY-P--RSLLILDDIWDSWVLKAFDSHHQILLTSRDK SVTDAMM-GPKYAVPVESGLRKEKGLEILALFVNMKKTDLPEQAHSIVKECKGSPLVVSL IGALLHDFPNRWGYYLRQLQNKQFKRIRKSSSYDYEALDEAMSISVERLSEDLQKYYKDL SILQKDVRVPTKVLCILWDMETEEVEDILQE----------------------------- ----------FINKSLLFYDRNGKSFRYYLHDLQV---------DFLMEKNRDQLKELHR KVVTQFQRYCQAHSLPSDQED----------------------SMYWYNFLAYHMASADM RQELCNL-MFSLDWIKAKTELVGPAHLIHEFMRYRHLLDKKD----CTICENFQEFLSLN GHLLGRQPFPNIVQL-----------GLCEPETSEVYRQ-AKLRAKQEVDKGKLYLEWIN KKTIKKLSRL-----VVRP-----HTDAVYHACFSKDGQRIASCGAD---KTLQVLQAE- TGERLLEVEA-HEDEVLCCAFS--KDGLFIATCSADRKVKIWNSRTGELVHTYDE-HTEQ VNCCHFTN-MEH-HLLLATGSSDCF--LK----LWDLNKQECRNTLFGHMNSVN--HCQF ------SPDDTHLASCSADGTLKLWDVSS--ANE-------------------------- -----------------CSSIDVKQHFLTGDGRQDDVDVVVKCCSWSNDGARLMAAAANR L----------------------------------------------------------- -------------LVFDVQSRNLLGEI-HTSHSSTIRFCDFFPKSHLAAVALSHYCVELW NTDTGL---------K------------VAD----------------------------- --CRGHLSWVHCVAFSPDGSSFLTSS-DDQTIRLWE-TRKVCKNSAIMLKQEVDVAFRDD EVMVLAIDNIRRL-QLINGKTGHTDYLTEAHKSRISCCCLSPGLRFVAFGEEDGSIKILE LPNG----REFRSRIGHEKAVRRVQF----TPDGRTL-ISSSDDSTVQV-WNW----QSE EFVFLKAHQEPVKDFRLLQNS----RLLTWSFD---GTV-KVWNILT--GKVEKDFTCHQ G-TVLSCDVS----PNAT-----KFSSTSADK----TAKIWNFE---SSFPLH-ELRGHE GCVRCSVFSGD-NALLATGDDN-GEIRIWSVSSGGLLHSCLPLTVEEGEATYGGWVTDLH FSPDGRMLVSAG--GYLK--WWDVDTGESLQTFYTNGTNLKTIHVSPSFRAYVTVDNLGI LYI--------------------LQALE-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >R_norvegicus_ENSRNOP00000010869 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MDAKARNCLLQHKEALEKDIKTSYIMDH MISNGVLTVVEEEK---------------------------------------------V KSQAT-------------------------------QYQRAAALIKMILNKDN------- ---------Y---AY--ISFYNALLHEGYKDLAGLLHSGLPL--VSSSS-GKDTDGGNTS F-------------VRTVLCEGGVPQRPVIFVTRKKLVSAIQQKLWKLNGEPGWVTIYGM AGCGKSVLAAEAVRDHALLE-GCFSGGVHW-VSIGKQDKSGLLMKLQNLCTRLGQ--EES FSQRLP-LNIEEAKDRLRVLMLRKH-P--RSLLILDDVWDPWVLKAFDNQCQILLTTRDK SVTDSVM-GPKYVIPVESGLGKEKGLEILSLFVNMKKEDLPVEAHSIIKECKGSPLVVSL VGALLRDFPNRWAYYLRQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDL SILQKDVKVPTKVLCVLWDLETEEVEDILQE----------------------------- ----------FVNKSLLFCNRNGKSFCYYLHDLQV---------DFLTEKNRSQLQDLHR KMVTQFQRYHQPHTLSPGQED----------------------CMYWYNFLAYHMASAGM HKELCAL-MFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKD----CAVCENFQEFLSLN GHLLGRQPFPNIVQL-----------GLCEPETSEVYQQ-AKLQAKQEVDTGRLYLEWIN KKTIKNLSRL-----VVRP-----HTDAVYHACFSQDGQRIASCGAD---KTLQVFKAE- TGEKLLDIKA-HEDEVLCCAFS--SDDSYIATCSVDKKVKIWDSGTGKLVHTYEE-HSEQ VNCCHFTN-KSN-HLLLATGSNDSF--LK----LWDLNQKECRNTMFGHTNSVT--HCRF ------SPDDELLASCSADGTLKLWDVRS--ANE-------------------------- -----------------KKSINVKRFFLSSEDPPEDVEVIVKCCSWSADGDRIIVAAKNK V----------------------------------------------------------- -------------LVMETQSSGKSSHC-FSLLRRPLRIYFLNPFDNLMLIDSSKFAVQLL HHTIRL---------S------------FNG----------------------------- --CEPGLSSLMSQLFWMTDSTQLFLV-PLSLTQVWE-TRKVCKNSAIVLKQEIDVVFQEN EMMVLAVDNIRGL-QLIAGKTGQIDYLPEAQ---VSCCCLSPHLEYVAFGDEEGAIKVLS STNS----RVQSAKNFHLKAFLHYRF----TRICKER-IESCENCSVFG-VEW----QTE EYVFLQAHQETVKDFRLLRDS----RCFPGSFD---GTV-KVWNVIT--GRIERDFTCHQ G-TVLSCAIS----SDAT-----KFSSTSADK----TAKIWSFE---LPSPLH-ELKGHN SCVRCSAFSLD-GILLATGDDN-GEIRIWNVSDGQLLHLCAPISIEEGTATHGGWVTDVC FSPDRKMLVSAG--GYLK--WWNVVTGESSQTFYTNGTNLKKIHVSPDFRTYVTVDNLGI LYI--------------------LQVLE-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >T_guttata_ENSTGUP00000009081 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------NMDVKSRNYLLMNRQALENDIKTSYIMDR MISDEVLTLQEEER---------------------------------------------V KQQNT-------------------------------QKERAAMLINIILTKDN------- ---------N---SY--RSFYNALLHEGYRDLAALLQDGIPA--VSSGN-RKSSMDGMTS Y-------------VKTILCEGGVPQRPVVFVTRPKLVDAIKKKLYCLGSDPGWVTVYGM AGCGKTVLTAEALRDPQLLE-DYFPGGVHW-ISVGKQDKAGLLIKLQNLCSRLEH--DST LSQRPP-LNIEEAKDRLRLLMLRKY-P--RSLLVLDDIWDSWVLKAFDNQCQVLITSRDR SVTDAVA-GNKYEVHVESGLAHEKGLEILSLFVNMKISELPEQANSLVRECKGSPLVISL IGALLRDFPSRWEYYLRQLQNKQFKRIRKSSSYDYEALDEAMSISVEQLDDNYKDYYKDL SILPKDVKVPTKVLCILWDMETEEVEDILQE----------------------------- ----------FVNKSLLFCDRNGKSFHYYLHDLQL---------DFLTEKNRNQLQELHK NIVNQYKKYYKLNTPVLSQED----------------------CMYWYNFLAYHMAGAKM QQELRDL-MFSLDWIKAKTELVGPAHLIHEYVEYSSVLDQKD----STVRENFQEFLSLN GHLLGRQPFPDIIQL-----------GLCQPETSEVYQQ-AKLHAQRE--TGTFYLEWIN KKSLKNLYRL-----VVRP-----HRDAVYHACFSKDKQRIASCGAD---KTLQVFKAE- SGERLLEINA-HDDEILCCTFS--ADGEFVATCSSDKKVKVWNSRTGQCRCVYEE-HSEQ VNCCQFNN-KSG-QYLLATCSNDTF--IK----IWDLNKKYCRNTMIGHENSVN--HCRF ------SPNDEYVASCSTDGTVKLWESRS--GNE-------------------------- -----------------LKSIEIKDFFKNADEQPDDVEVLVKCCSWSRNGDKILVVAKNK L----------------------------------------------------------- -------------LLFDINTCGLLTQV-IVSHHSTIQYCDFCPGDELVAVALSHCSVELW NIKSLS---------K------------VAY----------------------------- --CRGHMSWVHCVTFSPDGSLFLTSS-DDQTIRIWE-TKKVCKSSDAVLKSELDVVFHNG EVMILAIYNQKNL-QLINGNTDNVIMQTAAQESPISCCCLSEDLKFAAFGQESGTIKVLQ LSDG----KVLKSWEAYRTSVQHCRF----TPDCQTL-ISSAHDPVIQV-WNW----QLS ECVFLRGHNEAIKDFRLLENS----KILSWSFD---GTV-KVWNITT--GNPERDFACHR D-AVLSCAVS----PDGS-----KFSSASADK----TAKIWSFE---SSSVLH-ELKDHE ACVRCCTFSPN-NKLLATGDDK-GEIRIWDVLTGTLLHFCSPVTVDEGEPTHGGWVTDLS FSPDSKMLVSSG--GYLK--WWNVTTGESLQTFYTNGTNLKSIHVSPNFKVYVTVDNLGI LYV--------------------LQ----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >G_gallus_ENSGALP00000037436 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MDENSRMCLITNRQALEKDIKTSYIMDH MVADQVLTLQEEEK---------------------------------------------V KQQNT-------------------------------QKERAAMLINTLLTKDN------- ---------N---AY--RSFYNALLHEGYRDLAALLQDGIPA--FSSKN-GKNAMDERTS Y-------------VKTALCEGGVPQRPVVFVSRPKLVDDIKQKLRSLGSDPGWVTVYGM AGCGKTVLTAEALRDHQLLR-GCFPGGVHW-ISVGKQDKAGLLIKLQNLCSRLEH--DST LPQRPP-LNIEEAKDRLRLLMLRKYQS--RSLLVLDDIWDSWVLKAFDNQCQVLITSRDR SVTDAVS-GNKYEIHVESGLTHEKGLEVLALFVNMKISELPEQASCIVTECKGSPLVISL IGALLRDFPSRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEQLSNDLKEYYKDL SILPKDVKVPTKVLCILWDMETEEVEDILQE----------------------------- ----------FVNKSLLFCDRNGNSFHYYLHDLQL---------DFLTEKNCNQLQELHK NIVNQYKRYYKLHVPVLSQED----------------------CMYWYNFLAYHMAGANM QKELRDL-MFSLDWIKAKTELVGPAHLIHEYVEYSSVLDEKD----SIIRENFQEFLSLN GHLLGRQPFPDITQL-----------GLCQPETSEVYQQ-AKLRAQRE--TGTFYLEWIN KKSLKNLSRL-----VVRP-----HRDAVYHACFSRDRQRIASCGAD---KTLQVFKAE- SGERLLEISA-HDDEILCCTFS--ADDKYVATCSADKKVKIWNSRTGKCLYVYEE-HTEQ VNCCQFNN-RRG-QYLLATCSDDTY--IKNTVQLWDLKDKYCRNTMFGHVNAVS--HCRF ------SPNDDYIASCSTDGTVKLWNVHS--ANE-------------------------- -----------------LRTIEIKDFFRNADEQQDDVEVLVKCCSWSRSSDTILVVAKNK L----------------------------------------------------------- -------------LLFDVTTSNLLTQV-IISHHSTIQYCDFCAGDELVAVALSHCSIELW NIKSLS---------K------------VAD----------------------------- --CRGHTSWVHCVTFSSDGSLFLTSS-EDQTIRIWE-TNKVCKSSDAVLKSELDVVFHNG EVMILAIYNQKHI-QLINGNTDSIIMQTEPQESLICCCCLSEDLKFAAFGQENGAIKVLR LLDG----RVLTSREAYRTSVQHCRF----TTDCQTL-ISSAHDAVIQV-WNW----QLN ECVFLKGHKEAIKDFAFLENS----KLLSWSFD---GTV-KVWNITT--GKTEKDFACHR G-AVLSCAVS----PDGS-----RFSSTSADK----TAKIWSFE---SSSVLH-ELKGHE ACVRCSAFSPS-NKLLATGDDK-GDIRIWDILTGELLHFCSSVTVDEEEPTHGGWVTDLS FSPDSKMLVSSG--GYLK--WWDVTTGESLQTFYTNGTNLKSIHVSPNFDVYVTVDNLGI LYV--------------------LRKL--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >A_carolinensis_ENSACAP00000012965 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TMDLTARSHLLQNREALERDIKTSYVIDH MIADGALTPQEEAE---------------------------------------------V KAVTT-------------------------------QRDRAAKLIKTILKKDD------- ---------H---AY--ISFYNALVHEGYKDLAALLQDGIPI--ISPRN-GNKSTDGVTS Y-------------VKTILCEGGVPQRPVVFATRPELTKRIQRKLYKLKSDPGWVVIYGM AGCGKTVLAADALRDHNLLK-DCFPGGVHW-VSIGKQDKSGLLIKLQNLCLRLDQ--DVT YLQRPP-LNIEEAKDRLRVLLFRKY-P--RSLLVLDDIWDSWVLKAFDSHFQILLTSRDR SVTDSVT-GKKYEVPVESGLSHEKALEILSLFVNMEITELPEKADWIVKECKGSPLVVSL IGALLRDFPNRWEYYLRQLQNKQFRRIKKSSSYDYEALDEAMSISVEMLPENSKDYYRDL SVLQKDVKVPSKVFCVLWDIETEEAEDILQG----------------------------- ----------FVNKSLLFCDRNGKSFHYYLHDLQL---------DFLTEKNRDQLQALHK KVVHQYKNHYAQYMPNSTQED----------------------WMYWYNFLAYHMSSASM HDELCAL-MFSLEWIKTKTELVGPAHLIHEYVEYSEILNEKD----PIARENFQEFLSLN GHLLGRQPSLDIVQL-----------GLCQPESSKVYQQ-AKLQAQQGLDKGSFYVEWMN KQSIKNTYRL-----VVRP-----HTDAVYHACFSQDRHRIASCGAD---KTLQIFKAE- SGEKLLEVKA-HDDEVLCCSFS--ADDRFVATCSADKKVKVWNSRTGQPVCIFEE-HTEQ VNCCQFSN-TNHNQFLLATCSNDSF--IK----LWDLNKKYCRNTLFDHSSSVT--HCRF ------SPNDKYIASCSADGTLMLWYAQS--ANK-------------------------- -----------------RKTVDIRGNFRNVDEYQDDMEVLVKCCSWSSDSTTIVVAAKNK L----------------------------------------------------------- -------------FRTDTKISTSLPEV-LINHHYTIQYCDFCPNSQMVAVALSNYSVEIW NIESCS---------K------------IAD----------------------------- --CRGHMSWVHSVTFSFDGSLFLTSS-DDQTIRIWE-TSKVCNFSAIVLNREIDVLFLDS DVIILAIDSSKRL-QLISGYTGNTIYLTKEQDSLICCCCLSHDRKVAAFGENNGTVKVLS LQNG----NTLNSRTGHREAVQHCQF----TSDGKTL-ISSSDDSTIQV-WNW----QSE ECILLKGHNERVKKFLLLKDS----RLLSWSFD---GTV-KLWNIVT--GEIEKDVICHE N-AILSCAIS----PDAT-----MFSTTSSDK----TAKIWSFE---TSSMLH-KLNSHE SCVRCCAFSLN-NELLATGDDN-REIRVWDVSRGELLHLCSRASIDEGESAHEGWVTDLC FSPDNKILVSSA--GYIK--WWNVDTGQPLQTFYTNGTDLKSLHVSPDFKVCVTVDNLGI LYV--------------------LRIME-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >G_gorilla_ENSGGOP00000008216 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MDAKARNCLLQHREALEKDIKTSYIMDH MISDGFLTISEEEK---------------------------------------------V RNEPT-------------------------------QQQRAAMLIKMILKKDN------- ---------D---SY--VSFYNALLHEGYKDLAALLHDGIPV--VSSSS-GKDSVSGITS Y-------------VRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGM AGCGKSVLAAEAVRDHSLLE-XXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXX--XXX XXXXXX-XXXXXXXXXXXXXXXXXX-X--XSLLILDDVWDSWVLKAFDNQCQILLTTRDK SVTDSVM-GPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----------------------------- ----------XXXXXXXXXXXXXXXXXXXXXXXXX---------XXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXQED----------------------CMYWYNFLAYHMASAKM HKELCAL-MFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKD----CAVSENFQEFLSLN GHLLGRQPFPNIVQL-----------GLCEPETSEVYQQ-AKLQAKQEVDNGMLYLEWXX XXXXXXXXXX-----XXXX-----XXXXXXXXXXSEDGQRIASCGAD---KTLQVFKAE- TGEKLLEIKA-HEDEVLCCAFS--TDDRFIATCSVDKKVKIWNSMTGELVHTYDE-HSEQ VNCCHFTN-SSH-HLLLATGSSDCF--LK----LWDLNQKECRNTMFGHTNSVN--HCRF ------SPDDKLLASCSADGTLKLWDVTS--ANE-------------------------- -----------------RKSINVKQFFLNSEDPQEDMEVIVKCCSWSADGARIMVAAKNK I----------------------------------------------------------- -------------FLFDIHTSGLLGEI-HTGHHSTIQYCDFSPQNHLAVVALSQYCVELW NIDSRS---------K------------VAD----------------------------- --CRGHLSWVHGVMFSPDGSSFLTSS-DDQTIRLWE-TKKVCKNSAVMLKQEVDVVFQEN EVMVLAVDHIRRL-QLINGKTGQIDYLTEAQ---VSCXXXXXXXXXXXXXXXXXXXXXXX XXXX----XXXXXXXXXXXXXXXXXX----XXXXXXX-XXXXXXXXXXV-WNW----QLD KCIFLRGHQETVKDFRLLKNS----RLLSWSFD---GTV-KVWNIIT--GNKEKDFVCHQ G-TVLSCDIS----HDAT-----KFSSTSADK----TAKIWSFD---LLLPLH-ELRGHN GCVRCSAFSVD-STLLATGDDN-GEIRIWNXXXXXXXXXXXXXX-XXXXXXXXXXXXXXX XXXXXXXXXXXX--XXXX--WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGI LYI--------------------LQTLE-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >X_tropicalis_ENSXETP00000014654 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MDEKARSLLLQNRTALVRDIRTAYIMDH MISDQVITPEEEAQ---------------------------------------------V KSQRT-------------------------------QMDKANFLINLILGKSN------- ---------Q---AY--VSFYNALLHEGYKDLAVLLKEAANA--ELSDS-TKSSSNGITS Y-------------VKTVLCEGAVPQRPVVFVTRLKLVSKIQQSLYKLSVESGWVTVYGM AGCGKTVLAAEALRDHKILN-ECFPGGVHW-VSVGRQDKAGLLMKLQNLCTRLDQ--EAK YSQRPP-LNAEEARERLRLMVNRMY-P--RCLIVLDDVWDSWVLKAFDIQCRVLITSRDK SVTDSLP-GFKEAVHVDSELEHSKGLEILSRFLNIKAEALPSQAHNIIKVSKGSPLVVSL IGALLREFPTRWDFYLTQLKRKQFKRIRKSSSYDYEALDEAMSISVDNLKEDFKEYYNDF SIIEKDVKVPTQVLCILWDMEREDVEDMMQE----------------------------- ----------FVNKSLVYCDRNGKSYSYYLHDLQL---------DYLTERNRDRLTVLHS KLVDQYKKHYSSKSPAVDQED----------------------SVYWYHYLAYHMAKANM HQDLCSL-LFSLNWLKAKTELFGTAHLIHEFVQYRNILDNQN----AKAREHFQEFIAVN GHLLGSNPDVSIVQL-----------GLGQAEDSEVYKQ-AILQAKEELQSGALYVNWIN KQSIKNLPTL-----VVRP-----HKDAVFHACFSSDGQRIASCGAD---KTLQVFKSE- TGEKLLEIEA-HDDEVLCCAFS--ADEKLLATCSADRKVKIWNAKTGKPLRVYEE-HIEQ VNCCQFTN-SLS-APLLATCSNDCL--IK----LWNSEKNYCHNTLIGHIESVY--HCRY ------SPDDRYLASSSMDGSLKIWDVES--ANE-------------------------- -----------------EKSIEVAKLFENEDEAQP--EVLLKCCAWSNDGSRIMVTARNF L----------------------------------------------------------- -------------CIYDAERCNLLSQL-KACHQ--ILYCDFCTTNQIAALALSHYVVQLW DIDSST---------K------------IAD----------------------------- --FNAHLSWVHCVKFSPKSSSFLTSS-DDQTVKLWE-TSNVSKPAATNLKREFDVTFSGE RTLVLATSKDDCI-LLINGMTGETLSQIRAQDNCVTCCCLSTDYQLAAIGHRDGKVKILD LSGG----EILHKLDGHRDTVQHCQF----TADGKLL-VSSSDDCTVRV-WNL----VSG KNLELCGHKEPVKFFKILQES----KVFSWSFD---GTV-KVWNLLT--GQLIKEFICHS A-TVLACDIS----PDST-----KFSSASTDK----SAKIWNLD---NCALLH-ELNKHQ SCVRCCRFSWD-NQYLATGDDS-GKIMIWSVQNGELLRECCDVSVNNENSLHDGWVTDLH FSPDNKLIVSSG--ANIK--WWEVDTGACKQTFYTIGTNLKSIHVCSIFRTFVTIDNLGI LYV--------------------LQLIE-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >O_cuniculus_ENSOCUP00000010200 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------EE---------------------------------------------V -NECT-------------------------------QRQRAAMLIKMILKKDN------- ---------N---SY--ISFYNALLYEGYKDLAALLHGGIPV--VSGSS-GKDSVGGITS Y-------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXX-XCFPGGVHW-VSVGQQDKAKLLMKLQNLCSRLDQ--DES FFQRLP-LNIEEAKDRLRILMLHKH-P--RSLLILDDVWDPWVLKAFDNQCQILLTTRDK SVTDSVM-GPKYVVPVESSLGKEKGLEILSLFVNMKKTDLPEQAHSIIKECKGSPLVVSL IGALLRDFPNRWEYYLRQLQNKQFKRIRKSSSYDYEALDEAMSISVDVLREDIRDYYTDL SIFQKDVKVPTKVLCILWDMETEEVEDILQE----------------------------- ----------FVNKSLLFCDRNGKSFSYYLHDLQV---------DFLTEKNRSQLQXXXX XXXXXXXXXXXXXXXXXXXXX----------------------XXXXXXXXXXXXXXXXX XXELCAL-MFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKD----CTVCENFQEFLSLN GHLLGRQPFPNIIQL-----------GLCEPETSEVYQQ-AKLQAKQEVDNGMLYLEWI- KKNIKNLSRL-----LVRP-----HTDAVHHASVSA-AHRIASCGAD---XXXXVFKAE- TGEKLLEIKA-HEDEVLCCTFS--TDENFIATCSVDRKVKIWNSVTGELVRTYDE-HSEQ VNCCCFTN-QSQ-YLLLATGSSDFF--LK----LWDLNQNVCRNTMFGHTNSVN--HCRF ------SPDDKLLSSCSADGTLKLWDVKS--ANE-------------------------- -----------------VKSINVKKFFLTSEDPQEDMEVIVKCCSWSADGARIMVAAKNK I----------------------------------------------------------- -------------LXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLW NMDSRL---------K------------VAD----------------------------- --CRGHLSWVHGVMFSPDGSSFLTSS-DDQTIRVWE-TKKVCKNSAIVLKQEVDVVFQEN EVMVLAVDDVRCL-QLINGKTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDEDGTIEILE LLNS----RIFQSRIGHKKTVRHIQF----TADGKTL-ISSSDDSAIQ------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >D_rerio_ENSDARP00000008347 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MEERARSRLLRSKATLEQDIKASYLMDH MISDGVLTNDEEAK---------------------------------------------V LSKAT-------------------------------RKEQAVALLETLLRKDN------- ---------R---AY--ISFYNALIRESYGDLASLLHSDLPL--LSPEG-EKSFADGVSP S-------------VQAILSVGGVPQRPVVFVSRPPLLNLIREMLYRLRDTPGWVTVFGM AGSGKSVMAAEVVRDRSLIK-ECFPDGVHW-LSVGQCERADLLVRMQSLCFRLEQCQSSD TSQRPP-STVEEAKERLRFLMLRRF-P--RSLLILDDVWDSSSLRSFDIQCRVLLTTRNR ALTDSVS-GVRYEVPVENGLDEEKALEILALYVNGKMHKLPEQARSIVSECKGSPLVVSL IGALLREFPDRWSYYLRQLQQKQFKRIRKSSSYDYEALDQAMDASLQVLEAEHQELYRDL SVMQKDIKVPAKVLSVLWGLELEEVEDVLQE----------------------------- ----------FVNKSLLFRDCNQRPYRYYLHDLQL---------DFLAEQNRDQIAELHK KMVRQYQRFYSKRPPDSADKD----------------------SLYWYQFIPYHMAKAGL SKELYSL-MFSLDWVKEKARIMGSAHLINDYVEYGEILDKEN----SEVRVQFQEFLSLN GHHLEQRPFPDVVQL-----------ALSQPDRSEVYRQ-ALMQAQKRASRGQIYLNWVN KNIEEGLSRL-----VMHP-----HQGAVYYACFSKDGSKIASCGAS---KALRVFKST- SGEKLLELQA-HEEDVLCCAFS--PDDRHIATCASDKKVKLWNVERGVLIREFEVEHEEQ INHCQFTN-TGR-RVLLATCSNDKFTNTK----LWNPNKKTSQNTMFGHMEPVN--HCCF ------SPNDLYLATSSSDGSLKLFEVSS--ANE-------------------------- -----------------WKSIDVDSFFPESDE---EIKAMVKCSTWSADGSQIICAARNT V----------------------------------------------------------- -------------FVFDVETSDLLLEL-KTSRLSTIQFCHACPNSSLLAVALSHYTVELW NFESSK---------K------------KAE----------------------------- --CSGHLSWVHCVQFSPDGSLLLSSS-DDQTIRLWE-TDRVHTSSAVALKRDTDVLFSHS DATIIAPDSSNRL-QVLSGSTGAVVLESEELSSRIRCSCISRNAAFVALGSEDGTVQVIE VPSS----KASVKLSGHTKTVHHCQF----TDDCEIL-ITSSEDSTIRV-WKW----RTG ECMVLQGHMEPVRKFHLLSSS-SSPRLFSWSFD---GTV-KVWDLTR--GQMLQDLVCHE G-AVLSCDVS----SDGR-----LFATTSANR----TAKVWSSA---SWKMIF-LLEGHK DCVRSCRFSWD-NKRLATGDDN-GEIRLWSMLDGALLKICSRDTKDSMDSYHGGWVTDLH FSPDNRVLVSTG--GYIK--WWSVESGEALQTFYTMGGNLKKIHVSPDFSTFITVDSIGI LYI--------------------LKRLEGEGT---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >T_rubripes_ENSTRUP00000033561 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------LEEGARSSLLRFRHQLEQDIKPSYLMDH MISDGVLSVDEEEK---------------------------------------------I RTLAT-------------------------------RKDQAVALLDLLLRKDN------- ---------R---TY--ISFYNSLVKETYDDLATLLHEYLPR--LSPGA-TKNASDGCTP Y-------------VQTVLSEGGVPQRPVVFVSRPELVNQIREKLYRLQKEPGWVTVFGM AGSGKSVLAAEAVRHHSLIE-ECFPGGIHW-LSIGQLDKPDLLVKIQALCFRLEQGLDSQ SLHRPP-NSLDEAKERLRYLMLRRH-P--RSLLILDDVWDSMVLKTFDIHARILLTTRNR SLTDSVG-GAKYEVEVESGLDEKKGLEILALYTDNKPHGLPEEARSIVRECKGSPLVMSL IGALLKEKPNRWCYYLRQLQQKQFKRIRKSSSYDYDALDQAMAASIEVLPPEHQELYKDL TVLEKDIKIPAKVLSVLWVLEPEEVEDILEE----------------------------- ----------FVNKSLLYVDINHKPYLYYLHDLQL---------DFLVEQNQAQLERLHT KVVQQYQLHYKGDPPLSGDEE----------------------CLYWIRFLTLHMAKAGL SQELYSL-MFSLDWVSIKARIMGPAHLISDYVEYGHILDKKN----SDVRSQFQEFLSLN GHHLEQRPFPDVVQL-----------ALSQPHASDVYRQ-ALQEAQEQASTGKLYFDWLN KNSMESLSHL-----VIHP-----HQGSVYSACFSRDGTKIASSGAC---KTLKVFKST- TGEKLTEIMA-HDDEVLCCAFS--PDDRLLATCSSDRKVKVWNVEQARLLRVFEEEHEEQ VNHCQFTN-TMR-RLLLVTCSNDACMNVK----LWNLNKPSSQNTMFGHFEPVN--HCCF ------SPDDAIVSTSSNDGTVKLFRASS--ANE-------------------------- -----------------WKTISVRDQVAENDE-----EVLVKCSTWTADGKRIICAARNA V----------------------------------------------------------- -------------LVFDVETSDMLLEI-KTSRLSMVQYCHACPTSNLLAIAFSNYAVELW DLEANK---------K------------MAD----------------------------- --CSGHLSWVQRVQFSPDGSQLLSCS-DDHTVRLWE-TTKVHTSSAVCLKRDSDVLFDQE EIIISAADNCNRL-QVRNGRTGSVLFQSEEKSSRIRCTCLCRQPPAVVIGQEDGTVQVLE LPTG----KVLATLLGHTKTVFCCQF----SQDGQTL-ITSSEDTTIRV-WRW----LSG ECKVLQGHREQVRCFTLLSSSPSKMRLLSWSFD---GTV-KMWDTES--GEKLQDVEAHQ G-AILSCHVS----PDGC-----LFATTSADR----TAKLWHCE---SWQCVH-ALKGHQ ECVRSCRFSWD-SRRVATGDDN-GEIRLWSVSDGSLLKICSRDSKDGMDSLHGGWVTDLH FSRDDSLLVSTG--GYIK--WWDVAQGEALQTFHPTGSALKRIHVSADFSTFVTIDNIGI LYV--------------------LQRVIASGC---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >T_nigroviridis_ENSTNIP00000013938 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------LEERARSCLLRFRHQLEQDIKPSYLMDH MVSDGVLSIDEEDR---------------------------------------------I RTLPT-------------------------------RRDQAVALLELLLKKDN------- ---------R---AY--ISFYNSLVKVAYNDLATLLFEALPR----------SASDGCTP YGNRLITSFAVCPTVQTVLSEGGVPQRPVVFVGRPELVNQIREKLYRLQKGSGWVTVFGM AGSGKSVLAAEAVRHHSLIE-ECFPGGINW-LSIGQLDKPDLLVKIQSLCFRLEQS-DSQ SLHRPP-NSLDEAKERLRHLMLRRY-P--RSLLILDDVWDITVLKTFDIHCRILLTTRNR SLTDSVG-GNKYEVEVESGLDENKGLEILALYTDNKPHGLPEEACSIVRECKGSPLVVSL IGALLKEKPNRWSYYLRQLQQKQFKRIRKSSSYDYDALDQAMAASIEVLPDEHQELYKDL TVFEKDIKIPAKVLSVLWDLEPEDVEDILEE----------------------------- ----------FVNKSLLFVDSNHRPYLYYLHDLQL---------DFLVEQNRTQLERLHT KVVQQYQLHYKDGPPLSGDEE----------------------CLYWVRFMTYHMAKAKL SQELYSL-MFSLDWVSIKAQIMGPAHLISDYVEYGHILDKEN----SDVRSQFQEFLSLN GHQLEQRPFPDVVQL-----------ALSQPHASEVYRQ-ALQQAQERASTGKLYFDWLN KNSVESLSRL-----VIHP-----HQGSIYSACFSHDGTKIAASGAY---KTLKVFKST- TGEKLTEIQA-HDDEVLCCAFS--PDDRLLATCSSDRKVKVWNAERAMLLRVFEEEHEEQ VNHCQFTN-TMR-RLLLVTCSNDEFMNVK----LWNLNKPSSQNTMFGHTEPVN--HCCF ------SPDDTYVSTASNDGTVKLFQVSH--ANE-------------------------- -----------------WKTINVRKRLTENDE-----EVLVKCSTWTADGKQLICAARNA V----------------------------------------------------------- -------------LVFDVETSDLLSEI-KTSRLSTVQYCHACPTNNLLAIAFSNYAVELW DLEANK---------K------------MAD----------------------------- --CSGHLSWVQLVQFSTDGSQLLSCS-DDQTIRLWE-TTKVHTSSAICLKRDSDVLFDQE EIIISAADNCNRL-QVRSGKTGSVLFQSEEKSSRIRSTCLCRNPSAVVIGQENGTVQVLE LPTG----KVLATLLGHTKTVFWCQF----SQCGETL-FTSSEDTTIRV-WRW----RSG ECKTLLGHREQVRHFSLLSSSPSDTRLLSWSFD---GTV-KMWDTES--GEKLQDMEAHQ G-AILSCHVS----PDGC-----FFATTSADR----TAKLWHCE---SWQCVH-TLKGHQ ECVRSCRFSWD-SRRVATGDDN-GEIRLWSAKDGSLLKICSREGKDGMDSLHGGWVTDLH FSRDNTLLVSTG--GYIKKYWGSIPSLQSAHFF--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >G_aculeatus_ENSGACP00000026214 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------LEEGARSCLMRFRHRLEDDIKPPYLMDH MVTDGVLTGDEEER---------------------------------------------I KNQPS-------------------------------RKDQAAALLALLLMKDN------- ---------R---AY--ISFYNAMVQEGYNDLANLLHRDLPL--GLPEG-LKRSTDCCTP Y-------------VQTVLSEGGVPQRPVVFVSRPELVNRVREKLYRLQKEPGWVTVFGM AGSGKSVLAAEAARHHGLIE-DCFPGGIHW-LSIGQLDKPDLLVKIQSLCFRLEQSLDSH PLHRPP-NSLDEAKERLRFLMLRRH-P--RSLLILDDIWDSTVLKAFDLHCRILFTTRNR SLADSVS-GSRYEVEVESGLDENKGLEILALYTKTKLKGLPEEARSIVRECKGSPLVVSL IGALLREKPNRWRYYLGQLQQKQFKRIRKSSSYDYDALDQAMAASIEVLPDEHREFYKDL TVLEKDTKVPAKVLAVLWDLETEEVEDILEE----------------------------- ----------FVNKSLLFVDSHNKPFLYYLHDLQL---------DFLVEQNRTQLESLHS KVVHQYQQHYKDAHSTSGDEE----------------------CLYWIRFLTYHMAKANL FQELYSL-MFSLDWVSTKAQLMGPAYLINDYVEYGPILDKEN----SETRSQFQEFLSLN GHHLEQRPFPDVVQL-----------ALSQPRTSEVYKQ-ALLQARDRATTGKLYFEWLN KGSVESLSRL-----VIHP-----HQGSIYSACFSQDGAKIASSGAS---KMLKVFKST- SGEKLMEIQA-HDDEVLCCAFS--PDDRLLATCSSDRKVKVWNVERAMLLRVFEEEHEEQ VNHCQFTNSTTP-RLLLATCSNDKVLNTK----LWNLNKPSSQNTIFGHFEPVN--HCCF ------SPSDTYLSTSSNDGTVKLFHTSS--ANE-------------------------- -----------------WKTINVRDAFAESDE-----EVLVKCSTWTADGKRIICAARNA A----------------------------------------------------------- -------------LVFDVETSDMLLEI-RTNRLSTVQYCHACPTSNLLAIAFSNYAVELW DLEANK---------K------------MAD----------------------------- --CSGHLSWVQRVQFSRDGSQLLSCS-DDQTVRLWE-TNKVHTTSAVCLKRDSDVLFNDE EIIVSAADNCNRLQQVRDGRTGSVLFQSEEKPSRIRCTSMCRQPSAVALGQEDGTVQVLQ VPSG----NLLATLLGHTKTVLHCRF----SQSGKTL-LTSSEDTTIRKNWFL----RPF QKGKAVLSFSPFLSFEINNPTTGG------------GAF-CWLGGGV--SSRMRAWGFHE G-RLRQIRVG----GGGGGGKERMERNRKTNE----GPKLWHCE---TWKCVH-TLSGHR DCVRSCRFSWD-GRRLATGDDN-GEIRLWSVMEGTLLRICSRDGKDCMDSLHGGWVTDLH FSPDNGLLVSTG--GYIK--WWDVETGEALQTFFTTGTALKRIHVSSDFSTFVTIDSIGI LYV--------------------LQRVVIDRGYGA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >O_latipes_ENSORLP00000019346 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------LDERARACLLKSRHKLEEIMKPAYLMDH MISDEAITVEEEDM---------------------------------------------I ANQNT-------------------------------KREQAAALVDLLLKKDN------- ---------Y---SF--RSFYNALLKEEYDELANLLKEDLPLTQFTSSS-QCPGEKCLGA V-------------VQTVLSEGGVPPRPEAFVHRPKEENEIREKLYKLQKQPGWVTVFGM AGSGKSVLASEAVRHKELIE-ECFPEGIHW-VSIGRLDKPDLLAKIQTLCFRLEQNLDSQ QFHRPP-STLDEAKERLRFLMIRKY-T--RTLLILDDVWDSTVLKAVDIHCRILLTTRNR SLADVVN-GSKHEVEVNSGLDEDKALEILSQLSKIEMYRLPEEALSIVKKCQGSPLAVSM IGSLLRENPDRWGYYLRQLEKKQFRRIRKSSSYNYEALDQAIAAGIEDLSDDYRDLYNLL TVLHKDVKVTAKMMSVLWGQDQVDTEDTLSE----------------------------- ----------FVNRAMLFVDSQSQPNVFYLHDLQL---------DFLLEQNKNQLKVLHK KMVERYQHRYKDRPLTSRDEE----------------------SLYWIRYLAYHMANANL FQELHSL-LFSLDWISVKGQIMGPAHLINDYLEYGSILDKEN----NEMCSEFQEFLSLS GHYLEQRPFPDIVQL-----------ALSQPHTSEVYRQ-ARLLAQERAKDGKLYFDLIN ETSVDSLSRL-----VIHP-----HQGSLY-ACFSNDGTKIASCGAT---KNLKVFKST- SGEKLSEFEL--RDEVVCCAFS--PDDSLLAVCSSGRTIQVWNVHQVKLLRTFQEEHKEQ INHCVFTN-TTR-RLLLATCSNDQMGNAK----LWNLNKPTCQNTIFGHFEPVN--HCCF ------SPDDNYVSTSSNDGTVKLFEATS--GNI-------------------------- -----------------WKSIDVRGMFKDPDN---DDEVAVRCSSWTADGKRILCAARNA A----------------------------------------------------------- -------------LMFDVETSDLLLEI-RPSFLSTVLHCDVCPTSNLLAMALSNYAVELW DIEENA---------K------------KAD----------------------------- --CSGHLSWVERVQFSRDGSQMLSCS-DDETIRLWE-TKKLHMTSAVFLKRNTDVLFNDD NIFVSAPDHCNRL-QV---RTGDTLLQSEKKPSRIRCTCLLRDLSVVALGQEDGTVQVLA VPSA----KPLATLLGHTKTVLHCQF----THYGQTL-ITSSEDCTIRV-WNL----PSG ECKVLQGHKEQVRCFALLSPSSNDSRLLSWSFD---GTV-KVWNTES--GQKLQDIDAHG G-AILSCHVS----PDGR-----LFATSSADR----TAKLWHCE---AWQCTF-TLTGHQ ECVRSCRFSWD-SECLATGDDN-GEIRLWNVNDGSLLRICSREVKDSMDSFHGGWVTDLH FSPDNSLLVSAG--GYIK------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >C_elegans_Y45F10B.10 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------MFRGKGQQQVSSTDNI KAMMTAAIGNKLEKRLPLVSTIFVVGNDEEEFNIERRTLWQDVLPDLQNLAFQSNFDLEF CDVPLENGELTNSVAEHVLQMWKD-----------NPRSWIVLLLGNRYGNVSVPTSLRK EEYESIRSSIFEENGNVRVFEKAYTINRNGAVEEYRLVPSAIKDKKQLAEIIKALQAGAK AAHEEGSINQVHEQRQNRFFSSPLETFVRSILQVSPCRCLFLLRKFDQLVADPNSPNAFL ETNDQ-------------------------------NSRKIEDLKNEITLKMNDRVMTHV LRPESTDINYFFNSRDGDKYREKIARQFNEKLKNHLADINPPVRPEPPKSPMVLA----- --------------ANEARTHQEFLENQLALGNLKRDYDKRLDELASVKVNRGVFLIQGT DLCGKTQALCRLYHKIS----DKDAYKVIF-FTNLTYSSNFAHEAWRTICLNICSISNID PKEVLEHFKLGGILKSLEELVQKADKP------VCIFIDDVHLLKFGHLLSQI--GRRTE TAPDNLS----LFMTSSNVAPVNAVFAVTQTVNVDVISENEVVGMVQKMAEKVDKKLTNE QISAIRPLMAAKDGILIAKSFTHEILFNGNSSMKGGMDGRMTRIEKEFGKLAVGNAVKFI AASSHGLTRLEIHDAI--SADREVLEEMNMSIVYSLLTLDGIIEALGPILRKVIIDDRQI IGIAHSGLISWLRNRYLTSSQDIRSAHLQLSDLFA---------DLLIDNEQSPRHEIAY QSFSQGIKRDNGSP-----------------------------NFRRLRLLWYHCLHSGN LDRLKELSLCHFEYVDYVTRYFGISHLLSLYEECATQILHHD------LQVISEQVLVPA LVTMARDSEQLAAEVIGRLRFTRH--ENSHFLNSLVDQAMSWVDLYNRQPLLVPLTCWIS PPATKVCRSF-----TLKD-----WKPGNTVLTLSANHQYILISGNQSDPGVIYAYHIA- SEQLIGTFKG-HTAAVTCLCSS--NDSSLFVSTSFDKTVNVWVFSQSTPTMSLTH-HTAK VTCAILTS-D---DQYLITASADSS--AK----MIKLETGEVMRSFNDHTGSVV--SLQL ------TSNNQFLITGSGDFVVQMWDVTN--GKC-------------------------- ------------------------------ISRMGGLMAPVSTLAITSNDAFVVVACEDE TLKVFSTVGGQELHELMGHEG---------------------KVNSLVCAQDDCQLFAAT KSKV---------FCYDIHNGQMIDVLDTAQPFPICSLKI--SSDNYFLISPCGPKVTIW NVTKRN--------------------------------------------------HDAH DVHADKEGFLTAVALSNDDKYAACGT-NNGIVALWD-LEVCQCVFTT------------- ---------------------------IQNKGDPITCIRYSVDSQYCISGNQAGCILILD AQNG----GVVRELFMHSSEVLSIM-----SLVHNKM-ISCDIQGKMVI-WELFGDDDTP EMVATGVKPPIFVPPTGRIM-----VGHCSLSNKEM----KIWAFPEEGPPVTRAKLSHS D-EITCFATS----PKGGN----FIATGSRDM----SLKIWQID---KGFLTQ-VLVGHE NVVTCCCISFD-ERLVVSGARD-EKIIVWNVQSGDMVCTV----------NTTAAITSLS MTGDSTVVFSTTEDGWVE--TWSTTKGRLLSTFNAHRPIKKLINSYESHRMLLLLENCAQ LPILCLHNTPAVGVEATRRRSARAQSVSSASNEPVASTSAGEIKKDPILS---------- -------SNNGGNAQSAPRATAPKPTFDMLERSKSRTSLIEKDRTTTLTQSNAPPPQKSN MCTLL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >C_intestinalis_ENSCINP00000010464 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MGITKQYLRYLSVAQF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GVLGSARCNVEYLSMR------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NTQ GRYVAAAACENVCVWDMRTLQLVL------------------------------------ ------------------------------------------------------------ ---------------LLQG-----DNQEVTCIKSSPNSQHLAVGYVD---GTIRIFSLV- TAESDVTFSG-HRTAISCLAFD--KAGMKLASGSHDTEVVVWDLVNESGLYRLKG-HKGI ITDCYFVK-Q---RNMLITSSKDTY--VK----WWDLDTQHCFKTMVGHRSEVW--SFCL ------TPDERRIITGSGDSELRIWSVEF--IAN--KDSMEA--PLVKLQKT-KLDDVTS NDVTSDDVISDDV-MQGIEERLVSCIKVGSVMRKGR--DRVVTLKVSKDGRLLTCHGNDK MVEFFRIFDEAEVALRIKK-----------------------KLKRAKKKQK------NE GQEENDI----TIERSIEDEISHVGSFTCAGKLSSLDLTAPTPNTYNTVALLRNNQIETV STISLL---------SQP----EYSSLKRLS----------------------------- --QLGHRTDTKSMCFTMDGMALLTTS--SESAKLWN-RSSHQCIRTL------------- ------------------------------KCSHPKCCLFVPGDRQVILGTQEGALELHD VASG----TLLETIQAHEGAVSCVAL----FPNKRGI-VSGGPDKKIKF-WEF----DLI SDENYSVS-S------------------------------KRVSL------THTRTFELD D-QILDVEFT----PNNR-----FIAASLLDC----SVKIFYVD---SLKFFL-SLYGHS LPPSCVSISSD-STLIVSGSPD-RNVKIWGLDFGDCHRSL---------FAHDNDVTGLK FVPDTHLFFSCGKDGLVK--QWDADNFTLIQVLQGHLGPVWSLCVSPDGDHVATCGNDRS LRL--------------------WNRSMEVVIPDEEREHEREKEEEKLLAKNQDTTVSGK SRSCTFYNFLRKKRTTVESVRGAEKIMEAIELFNEEKVKEEEFKFINK--NKDVFYKSDH ---------------PILRAYGNITVS--VMFFYFRLRDIELEESLLVLPFSYVPDLLQL LGTFVARGR--------------------------------------------------- ----------------------------EVELACRCIFFLLRIHHGRITTNQTLVNVLDD LRHNTETKIDQLRNTIGFNLAALGHIRRQFESKNDVTFFSDATQRANDKKKRRKRTTQRA VLTT-------------------------------------------------------- ----------------------------- >O_latipes_ENSORLP00000010395 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MGLTKQYLRYAPSAVF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GVIGSQKANIAYVTLRG------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GER GRYVAVAACEHVFVWDVRKGEKVL------------------------------------ ------------------------------------------------------------ ---------------ILQG-----QKHEVSFLCPSPDGVHVAVGYED---GAVRIFSLL- NGESSVAFNG-HKTAVTVMNYD--ALGARLVTGSKDTDVIVWDIINECGLYRLRG-HKDA ITQALFLK-N---KNLMVTSSKDSF--VK----WWDLDTQHCFKTMVGHRSEVW--ALAL ------LKQEKRLLTGSADSELRAWDIAA--LEE--IEDKTEGGPKVKKGKT---LLEED ED--DEEE---KE-DESLDERILSCKKAGSILREAR--DRVVSMTTDSRARVVACHGNDS VLELFTVLTEEEVQRKMTK-----------------------KMKKARKKAAKTSALEEA GGAAAEP----VVERTLKDEIVRLTNIKASAKIRWADCLSGAGGELKVALLLQNNTVETY SLKTSD---------ENP----SANKTARLT----------------------------- --LGGHRTDVRTLAFSSDNLAVLSAS--GDTVKVWN-RSTLQVIRTM------------- ------------------------------TCEYALCSLFVPGDRQIILGTKSGKLQIFE LASG----SLLETSDAHDGAVWSLCL----APDQRGI-VTGGADKTVKF-WEF----ELI KDQSSA-Q--------------------------------KRLAV------KHVRTLQLE D-DVLCVRFS----PDHR-----LLAASLLDC----TVKIFHSD---TLKFFL-SLYGHK LPVLCLDISHD-STLIATGSAD-RNVKIWGLDFGDCHRSL---------FAHDDSVMFLQ FVPKTHLFFTAGKDRKIK--QWDADKFELVQTLEGHHREVWCLAISPNGDHLVSASHDKS LRL--------------------WERTREPIILEEEREMEREAEFEESVAKGDAPVVPGE VEG----EAAPAAKKTVETVKAAERIMEALELHREELRKMEEHKYACEGAGKQLPPPKPN ---------------PVLVAFGNVSPARYVLDVIKAVRSSELEVSLLVLPFPYVPELLQL FSSYIHQGL--------------------------------------------------- ----------------------------EVELVCRCLFFLLKIHFGQITSNQMLLSVIDD LHSVTVSKVCEIRDVMGFNSAALQFLQRQIESQENVTFFAEATGRQTMNNREQKITQRST INRS-------------------------------------------------------- ----------------------------- >T_nigroviridis_ENSTNIP00000007980 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MGLTKQYLRYVASAVF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GVIGSQKANVAYVTLRG------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GEK GRYVAAAACEHVFIWDVRKGEKVM------------------------------------ ------------------------------------------------------------ ---------------ILEG-----QKHEVTFLCPSPDGVHVAVGYED---GAVRIFSLL- NGESNVSFNG-HKSAVSVMRYD--GLGARLVTGSKDTDVIVWDIINECGLYRLRG-HKDL ITQALFLR-D---RNLLVTSSKDSF--VK----WWDLDTQHCFKTIVGHRSEVQCGGMVL ------LDQDNRLLTGSADSELRAWDITY--LQE--IDESPE--EVQKPLSS----VLSR LL--AHPL---SL-PPPSLQRILSCHKAGSILREAR--DRVVSLTTDARSAVIACHANES VLELFRVLPEVEVQQKMKK-----------------------KEKKAKKKAAQAP--EDA AEDAGTP----AVTRTLKDEIVRLTNIKASAKIRWAECVWCSGGELKVALLLQNNTVETY SLRTAD---------KTP----AGTKTARLT----------------------------- --LGGHRTDVRTLAFSSDNLAVLSAS--GDTVKVWN-RATLQVIRTM------------- ------------------------------ACEYALCSLFVPGDRQIVLGSESGKLQIFE LASA----ALLESVDAHAGAVWALCL----APDQRGL-VTGSADKTVKF-WDF----ELV KDQDAG-H--------------------------------KRLTV------KHTRTLQLE E-DVLCVKLS----PDHR-----LLAVSLLDC----TVKLFYAD---TLKFFL-SLYGHK LPVLCLDICHD-STLIATGSAD-RNVKIWGLDFGDCHRSM---------FAHDDSVMFLQ FVPKTHLFFTAGKDKKIK--QWDADKFEHVQTLEGHHREVWCLAISPNGDHLVTASHDKS LRL--------------------WERTREPVILEEEREMEREAEFEESMAKGDVPVVPGE TPG----EAAPAGKKTVETVKAAERIMEALELFREERRKLEDHEYACRAAGRQLPAPKPN ---------------PILVAYGNVTPSRYVLDVIKKVRSSELEVSLLVLPFSYVPELLKL FNAYIQQGL--------------------------------------------------- ----------------------------EVELVCRCLFFLLRIHFGQISSNQMLLTVMDQ LRTNTLARVGQIRDVMGFNSAALQFLQRELESKEEVTFFAEATGKLKKVKLKGRRVEPRV SDLN-------------------------------------------------------- ----------------------------- >T_guttata_ENSTGUP00000006840 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------FPSSYAATRKIEPF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------YKGGRIQI--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SRD GKFMFCPCGSKVNVVDVETGALLHS----------------------------------- ------------------------------------------------------------ ---------------LQQE-----EEEDVTAFVLSPDDEVLVTGSRA---LLLRRWHWR- EPSCERTWRAVHTAPVATMAFD--PTATLLATGGCDSTIKIWDMTKHYCTHNLKG-SSGV VHLVEFHP-DLS-RLQLFSSCIDYK--IR----IWDLSSSKCLAVLEGHFSAVT--SLAF -------ADGNSLLSSGRDKICMVWDLET--RQS-------------------------- -----------------KRTIPVYETVEAAVLLPEK--GDFSQLGVKKQGLHFVTAGSKG VLRVWDVATAACVHSQAVPFT------------LREEPSEH-SLSQC-----QNEILTVS MEHNI--------VFYDAHSLQLRKQL-TGYNEEVLDVKFLGPGDSHIVVATNSPQLKVF ELATSH-----------------------------------------------------C QILYGHTETILALDVFRKGLMFVTCA-KDRSMRVWR------------------------ ---------------------------MG-QAGRVTC----------------------- ----------VAHAQSRFPALGGLIP----LRLKESFVVTSSQDCTIKI-WNI----PES LTSKAKAALI-S----------------------------SPEPL-----HARVTERGHD K-DINSVAVS----PNDK-----LLATGSQDR----LAKLWSCS---DCSLLG-VFSGHK RGIWCVQFSPV-DQVLATSSAD-GTLKLWGLRDFSCLKTF---------EGHDASVLKII FVSRGAQLLSSGSDGLLK--LWTIKTNECVKTLDGHEDKIWGLHSNKKDDMVVTASSDSC ITL--------------------WQDVTEIEEKEAQAKQEEQIMKEQEL----------- -------SNLLHEKRYLKALCLAISLDRPHTVLTVVKAILREPEGR-------------- ---------------------------------------RHLEENIVRLRKDQKEAVLAF LVTWNTNSR--------------------------------------------------- -----------------------------------------NCHEAQAVMETLLKHEAPD SLLQFSGIKSAVESLLPYTERHFQRLSRLLQASTFIEFMWQNMRLA-------------- ------------------------------------------------------------ ----------------------------- >T_nigroviridis_ENSTNIP00000004057 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------NMASSHLHFKTNYAVSSKIEPF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------YKGGRVQI--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SKD ENYIFCTCGSRVNVLEISTGKIVHS----------------------------------- ------------------------------------------------------------ ---------------VEHD-----DQEDITCFALSSDDELLVTASRA---LLLKQWDWR- QAQCTRSWRAIHTAPVASMTFD--STSTLLATGGCDGTIKLWDVVKQYCTHNLRG-SSGV IQLVQFHP-DID-RLQLFSSSMDCS--IR----IWDLSSSQCVCVLQSHYSAVT--SLSF ------SLDGDTMVSSGRDKICTVWDLKQ--QKA-------------------------- -----------------KRTIPIYEAVEGAVILPEN--QDFSQIGVKKPKLHFITAGSKG ILRVWDPNTARCVFSQTLTGVSAA-------------DNPR-SLTHLLLLPASLRLATVT AEHNI--------MLYQLPGLTTLQQF-VGYSDEVLDVKFLGKDDSHIVVATNSCQLNVF ELASNS-----------------------------------------------------C QILYGHTDTILSLDVFRKGLLFASCG-KDKLVCVWH------------------------ ---------------------------M--AGGSVRC----------------------- ----------VARGYSHTNAVGAVSC----SRMKASFVVSGSLDCTVKV-WDL----PAD LTAAE------D----------------------------NIHQL-----TPRATEKAHD K-DVNSVTVS----PNDK-----LLASASQDR----TAKLWSLAGEGSLGLLG-VCRGHR RGVWAVCFSPV-DQVLATSSAD-GTTKLWSLQDFSCLKTF---------EGHDASVLKVI FVSRGTQLLTSGSDGLVK--LWTIKTNECVKTLDAHQDKVWGLHGSRRDDKMVTGSADSN ITV--------------------WEDVTEIEMAEEQAKQEEHILKQQEL----------- -------SNLLQEKKYLKALGLAISLDQPHTVLTVIKAIRQTEDNS-------------- ---------------------------------------ELLEKTVLKLRVDQKEALLRF CVAWNTNAK--------------------------------------------------- -----------------------------------------NCQDAQVVLQVLLTHVPPE ELLQYQGARTHLEALVPYTERHMQRIGRLLQASMFLNYMWQKMRVVGEPSS-DASVTRRV SARIQA-----KEGN-RANSQQH------------------------------------- ----------------------------- >M_domestica_ENSMODP00000008927 ------------------------------------------------------------ ----------------------------IETMKSKGLEPSGQPGVLSLKNPILTQSTDLQ STVSASHLLQPFQPSPLIEASLKGMDTSNHLLLEPAARKAQDFTLGHFTKWPKRTLKAKL AKRKSVRGSWMAQWIEEEEEE----EEQVEEAIPLYNLSLR-KEKE-SEELMLELVSRDS DAQPENTDQVLQDKKMLLITKLCCALSSRANLLEAKDPTRNFLLQLCTDLALLEPEFILK ASLYARQQLNIRDMAIMVLAIAAYLPACRPYLRRYFCAIVQLPSDWMQVAQYFQNLAESP DKKLVPMPACLRAAMTEKFTQFDEYQLAKYNLREHRAKKRRRRYRRPVSDFFPVS-SHRS NPLYL-GTKRAKQNRKFMRAYHEEPVKKKPSDFTLKKLIKRLHIRDPVQNVKALLGCRYP SDLQSFSRSRLPGPWDSSRAGTRMKLPQPETWERVLSQQGNTASVWEGLIDSGKLPYMAM LRNLCSLLRVGISAKHHERILQLLERKESVIRSRQLPFRFLSAHTSISDLERQLKNSG-P VPCNVVIMRQLLERLEKKKKLPKPERKL---TNWDLRFAMMVPVLYEHFKREKQRLIQIS HWKRDWEMMKRYQQALETAMNLSVQHNLPPLPGRTLIICSPYESQDKKKVKKNQN--PLT HVLLLVAMLMARAEQAELLLCKRGTLKKAVTNPEEGILKTATELETQIQAF--HGEISES GHHPFVTYLLDMVTRRVLMDTVIFVGNTMKDFEFMTAKQFFWQRVNPKCLFVGVDLMGMD SCSL--STNPNDVILTGCTDGILKFISERGMSRLLEHVGQMDKIFKIPPPRGEAQTLPDR PLEEREPSPLTPAPQHSWRSVRIFISSTFRDMHGERDLLLRSVLPALQAQAAPHHISVRG IDLRWGVTEEEIQKDRQLELCLGE----------VENSQLFVGILGSRYGYVPPNSNLPD HPHFHW----------------VKDYPPGRSVTEMEVMQFLNRGSHQQGVSPALIYLRDS SFLSSVPDGWKIDF---------------------------------------------A SESDE-------------------------------AAERISDLKSYLDKQEGVTCHRYS CAWGGVAAGR---PY--VKGLEEFGQMVLQHVWELLQRLYVQPESSLEKTESAQNDDT-- --------------VQSAFQQLQHPPSPARPSLLKDIVQQLQQR------SGSLCLVTGE PGQGKTAFLSSLVSALQAPFGATRSSQVFFHFAGARPDQSYILTLLRRLCTYLRHQLQHS -KPFPT-TYRGLVWELHT-LLPKSAQTLRSGQTLVLVIDGADQL--GDQTGRLISDWIPK SLPQKVH----LVMSMSTSTGLADILQCRRDAHVVALRSLEPTARAQLVRQELALYGKRL EETPFNN-------------QMRLLLVKRGAALPLYLRLATDHLRLFTLFEQMSEQLRTL PAT-----VPLLLQHVLGVLEQEHEPDILPLALAALQVTRSGLTV--DRLHGVISTWRAL S-SETVDWAEAMAARNKGDPYPMGPFTYLIQSLRRLLGE-----G-SLELPGARLRLPPG PLSSAVELRYRKRPGLKTKAHVLIAVQLWKMCDPEALGTFHNCHPEALNDLPYHLVQSGN HSLLASL-LTNLNVTATYLELGLLSQLGEAHALYASSVPMSEPVSSETDVIAFHTFLKQQ SRLLTQYP-ALLTQQ-----------ATNQPSNSPIYQQVPKL---AQRWSSQPILRWLN KPQTMGSQQS---SSLSLV-----PSSMPTAVSLSPNGQWAVVATAS---GIVHLLDTR- TWQEEKSIVS-GCDGISSCLCP---SNSTVFLAASDGLLELWDLQGGWRVFQTKA-HQLQ ITDCCLSP-D---HRLLATVSLDRH--LK----LWDTVHGKLASQHL-SQKPLN--CVAF ------HPEEQVITTGNWAGCLSVLRLDS--LTV-------------------------- ----------------------------TMFIGLKGSESSVRAVTFAPSGTVLAASHLDG TVELWAWQKGAQLASFPAHLG---------------------YVASALFLQSGRQMLTAG EDGKV--------QMWSGSLGRPKGTL-DSLPLSPALSVAISPDRAFVAVGHHSDGIRIY RTSSGT---------EEGQCPVSDAAVSALAWLNPKVLVSGGEDGNLQCWMLAYVTPHRL WLLPAHQKAVLGLATSQE--LLASASAEDFTVRLWS-LQFLTQPNLA------------- -------------------KKLHPGRELRGHTGPVTCCSFSPDGGILATGSRDQSLLCWD VRMPEAPVVMHSLPACHRDWVTGCSW----TKD--AMLLSCSNDGSVRL-WDP----VSG QQLGQFLGHQSAVSTVVAVEE----HVVSVDRDGVL----KVWNL-R--GVELTSIPAHS G-PISHCVAIQEPRTAGQPGSELLVITVGLDG----ATRLWHPL---LVFQTH-TLLGHS GPIISAAASET-LGLLLTASKD-GSVRLWHVPKE-DDTGA---------GERPTAITAVA WAPDGSLAVSGSQAGELI--LWQDAK--AVARAQVPGR-VSALCWISPQTFFALISDKNL IKW--------------------QVK-KEGLLLDIFSLGHDLQLNQQD------------ -------SHNLLSGMDLAPDRCSLILAKPLLGML-LKVDSTPSEFWHKLSLHSLTLFSTH ---------------EEHGVFSLDTLR-NVLSIHQQTESSVLEHIKDFDLQLENPRGTPL WITQAKPESGFNSALGMADSAFLCASSEGVLWNMAECTPEGDWVTDNIWQDTEEEFD--- --------------------------FPKLKTQYSKKIHSGSVTALHVLPKVLLTASEDR DVKLWEKPNLQLRGLFRCEGAVSCVEPRPGPGPTLQLAVGDAQGHVYFLSWE-------- ------------------------------------------------------------ ----------------------------- >D_rerio_ENSDARP00000023281 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MGLTKQYLRYVASAVF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GVIGSQKANIAFVTLRG------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GEK GRYVAVGACEHVFIWDVRKAEKVL------------------------------------ ------------------------------------------------------------ ---------------ILEG-----KKHEVTYLCPSPDGVHIAVGYED---GGVRIFSLL- NGESNVSFSG-HKSAVSVIKYD--ALGARLVTGSRDTDVIVWDVINECGLYRLKG-HKDA ITQVLFLE-S---KNLLITSSKDSF--VK----WWDLDTQHCFKTMVGHRSEVW--GMVL ------LNQENRLLTGSADSELRAWDIQD--IEE--VKELGE--PQEKKVRT----LLED EE--EDEE---GP-DEEPEERILSCKKAGSILREAR--DRVVSLVTDAKAKVLACHGLDA TLEVFTVLSEEEIQRKMDR-----------------------KLKKAKKKAKS----QEG GEEASEP----VVERKLKDEIMKLANIRASSKIRSMDCLLVPNGEMKVVLLLQNNTVETY TLKTTE---------KNP----TGNKTSRLT----------------------------- --LGGHRSDVRTVAFSSDNIAILSAS--GDTVKVWN-RSTLQVIRTM------------- ------------------------------GCEYALCSIFVPGDRQIILGTKSGKIQIFD LASG----SLLETTDAHEGALWSMCL----SPDQRGI-VTGGADKTVKF-WDF----ELI KDEDSMIN--------------------------------KRLTV------KHTRTLQLD E-DVLCVRFS----PDQR-----LLAVSLLDC----TVKIFYTD---TLKFFL-SLYGHK LPVLCLDISHD-SALIATGSAD-RNVKIWGLDFGDCHRSM---------FAHDDSVMFLQ FVPKTHLFFTAGKDKKIK--QWDADKFEHIQTLEGHHREVWCLAISPNGDHIVSSSHDKS LRL--------------------WERTREPIILEEEKEMEREAEFEESLAKGDDPVVPGE TKG----EAEPAGRKTVETVKAAERIMEAIELYREESKNLEEHKAACEAAGKKLPPLKMN ---------------PILMAFGNISPSRYVLEVMKKVRSSELEVSLLVLPFPYVPDLLKL FNAYVKEGL--------------------------------------------------- ----------------------------EVELVCRCLFFLLRVHFGQITSNQMLLSVIDE LRANTISKVREIRDVLGFNSAGLQFLQREIESREDVTFFADATDRFEEKRRKRRKRERVI LTIT-------------------------------------------------------- ----------------------------- >G_gallus_ENSGALP00000008904 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MAATAAGSVVRFKSNYAVSRRIEPF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------YKGGRVQV--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SRD GKFMFCPCGTKLNVIDVETGALLHS----------------------------------- ------------------------------------------------------------ ---------------LEQD-----DQEDITSFVLSPDDEVLVTGSRA---LLLKQWNWR- ENRCVRTWKAVHIAPVATMVFD--STSTLLATGGCDSTIKIWDMIKQYCTHNLKG-SSGV VHLVEFHP-DIS-RLQLFSSSMDYK--IR----IWDLNSSKCVAVLDGHFSAVT--SLAF ------TADGNTLISSGRDKICMVWNLKT--RES-------------------------- -----------------IRTIPIYESVEAAVLLPEQ--GDFSQLGVKKQGLHFLTAGSKG VLKVWEVATAACVYSQPVPFEPVE---------SEEEASEH-SLTHCMLVPERNEIVTVS VEHNI--------VFYDAQTLQLRKQL-AGYNDEVLDVKFLGPGDSHIVVATNSPQLKVF ELSTSH-----------------------------------------------------C QILYGHTETILALDVFRKGLMFVSCA-KDKSIRVWR------------------------ ---------------------------MN-KDGRVVC----------------------- ----------VAQGLGHAHGVGAVSC----SRLKESFVVTSSQDCTIKV-WNI----PES LTSKAKAALI-S----------------------------GPETL-----HAQMTERGHD K-DINSVAVS----PNDK-----LIATGSQDR----LAKLWSCP---DCSLLG-VFTGHK RGIWCVQFSPV-DQILATSSAD-GTLKLWGLQDFSCLKTF---------EGHDASVLKII FVSRGTQLLSGGSDGLLK--LWTIKTNECVKTLDGHEDKIWGLHTNKQDDMVVTASSDSS ITL--------------------WKDVTEIEQEEAQAKREEQIMKEQEL----------- -------SNLLHEKRYLKALGLAISLDRPHTVLTVIKAILKESDGR-------------- ---------------------------------------KRLEENIARLRKDQKEAVLTF LVTWNTNSR--------------------------------------------------- -----------------------------------------NCHEAQAVIETLLKHEAPD NLLQYSGIKSAVESLLPYTERHFQRLSRLLQASMFIDFMWQNMKLSDVSQQEDMIL---- ------------------------------------------------------------ ----------------------------- >G_aculeatus_ENSGACP00000015863 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MANTNLQFKTNYAVESKIEPF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------YKGGKVQI--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SKD EKYIFCTCESRVNVLEISTGKIVHS----------------------------------- ------------------------------------------------------------ ---------------VQHD-----DQEDITSFALSFDDEMLVTASRA---LLLKQWDWR- EAQCTRSWRAIHTVPVASMTFD--STSTLLATGGCDGTIKLWDVLKQYCTHNLKG-SSGV VHLVQFHP-DIS-KLQLFSSSLDCG--IR----LWDLRSSQCVCVLQSHYSAVT--SLSF ------TPDGDTMVSSGRDKICTVWDLKT--RKA-------------------------- -----------------TRTVPVYETVEGVVLLPDD--EDLSDIGVTSKNLHFITAGSKG VLRVWEASTARCVYAQTLNSTLAAVSE---KEEEKDDDNDHCSLTYLLLLPASSRLATVT ADHNI--------VLYQLPALTTQQQF-VGYNDEVLDVKFLGKGDSHIVVATNSCQLKVF ELLTNS-----------------------------------------------------C QILYGHTDTVLSLDVFKKGFVFASCA-KDRSVRVWQ------------------------ ---------------------------MDSDSGRVHC----------------------- ----------VAHGSNHANAVGSITC----SRMKASFVVSGSQDCTLKV-WDL----PAD LSTTG------G----------------------------DLHHL-----TPRATEKAHD K-DVNSVAVS----PNDK-----LLASGSQDR----TAKLWSLEAAGRVGMLG-VFRGHR RGVWAVCFSPI-DQVLATSSAD-GAAKLWGLQDFSCLKTF---------EGHDASVLKVI FVSRGTQLLTSGSDGLVK--LWTIKTNECVKTLDAHQDKVWGLHGSRKDDKMVTGSADSN ITL--------------------WMDVTEVELAEEQAKQEDQILKQQEL----------- -------SNLLHEKKYLKALGLAISLDQPRTVLTVIKAIRQVQDSH-------------- ---------------------------------------KLLEKTVLKLRVDQKESLLRY CAVWNTNAR--------------------------------------------------- -----------------------------------------NCQDAQAVLQVLLTHLPPE ELLQYQGARTHLEGLIPYTERHMQRIGNLLQASMFLNYMWQKMRVAGAPSSMNRDEEMDT TPLAQPFLMIDKDEDPNDAVKEDEDDEEVSASNKASTNTGSVENGASPQTDGNHHCESEQ SSEEEDPEEVNVMKCLPVPTALKCQTFAS >A_aegypti_AAEL004526-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MKKNEYEVQNQYKAF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------YTGGTVQW--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------TSD GSEMLCQNAGAINLVSVTDDTVEPVIF--------------------------------- ------------------------------------------------------------ ---------------GDAD-----ESDAVYTFALSKDSHNVVSAHRS---GLMKLWDKN- SRQVSKMWRGLHQGPITKLVFS--DDDTLIASGGTDTTVRVWDPKEQVCKGTLRG-CQGV INLLVFHP-DVE-SKILLAAGDDVK--IN----AWNYETRELVKSFAGHFSKVT--GVSF ------TSDHKFLVSSGRDKILIMWNYET--QQA-------------------------- -----------------VKTIPVYESLESVIVLPKG--VHLPGLKLKSDKVYAACAGEEG LIKVWEMTETKIVFKQKNSLVT-----------KSAEEGGL-AITDLLFNKQSSKLAIVS ADHNI--------IIHDLETFECSKQL-SGFSDEILDLILFGKKDHFLGMATNSNDFKIY DTTNMN-----------------------------------------------------C QLVKGHTDIVLSLSANQN--YILSSS-KDNSIRLWR------------------------ ---------------------------YDTAKFTVQC----------------------- ----------VAIGLKHTNAVGSIAI----SKVSGKFCASVSQDKCLKV-WKI----PKE FNETTDEK--------------------------------ELTRL-----NCTLTELAHE K-DINCVCIS----PNDR-----LIATGSQDK----TAKLWDAS---NLSLVG-VFRGHR RGIWAVRFSPV-DQILLTNAAD-CSIKLWSLTDMTCLKSL---------EGHESSVLRVE FLSHGMQLLSAGADGLLK--LWSIKTSECLQTLDKHESRIWALCVTEDESVFYSGGSDSQ LIK--------------------WKDVTDEKREREMNERKEVLLQEQEL----------- -------NNLLQDKKLLKALRLALNLDRPLMTLKIITSVIKSQE---------------- ---------------------------------------QGLPDTIQKLRNDHKETLLKH AIEWNTNSK--------------------------------------------------- -----------------------------------------NCRPAQLVLNILLQQMLSG EF-QVSELNKHLEAALPYTERHFKRMTEYAKDLKFIEYTLHCMQPHATTREANKTDKV-- ------------------------------------------------------------ ----------------------------- >M_musculus_ENSMUSP00000060613 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MGLTKQYLRYVASAVF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GLIGSQKGNIVFVTLR------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GEK GRYVAVPACEHVFIWDLRKGEKIL------------------------------------ ------------------------------------------------------------ ---------------ILQG-----NKQEVTCLCPSPDGLHLAVGYED---GAIRIFSLL- SGEGNITFNG-HKAAVTSLKYD--QLGGRLASGSKDTDVIIWDVINESGLYRLKG-HKDA VTQALFLR-E---RNLLVTSGKDTM--VK----WWDLDNQHCFKTMVGHRTEVW--GLVL ------VSEEKRLITGAADSELRAWDIDY--LQE--IDDPEE--PEPKKIKE--CPGIQD TP--ESEDSTLEADDEKSEDRILSCSKAGSIMREGR--DRVVNLAVDKTGRILACHGTDS VLEVFCILSKAEVQKKMDK-----------------------KLKKARKKARLNS--AN- EEEDPET----SVSMTLQDEILRVAKIKTSAKIKSFDLIHSPQGELKAVFLLQNNLVELY SLNASL---------PAP----QPVRTSRIT----------------------------- --IGGHRSDVRTLSFSSDNIAVLSAA--ADSIKIWN-RSTLQCIRTM------------- ------------------------------PCEYALCSFFVPGDRQVVIGTKTGNLQLYD LASG----TLLETIAAHDGALWSMSL----SPDQRGF-VTGGADKAVKF-WDF----ELV TDKNST-Q--------------------------------KRLSV------KQTRTLQLD E-DVLCVSYS----PNQK-----LLAVSLLDC----TVKVFYVD---TLKFFL-SLYGHK LPVLCMDISHD-GALIATGSAD-RNVKIWGLDFGDCHRSL---------FAHDDSVMYLR FVPKSHLFFTAGKDHKIK--QWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSASHDKS LRL--------------------WERTREPLILEEEREMQREAEYEESVAKEDQPAVPGE TQG----DNYFTGKKTIETVKAAERIMEAIELHREETAKMKEHRAICKAAGKEVPLP-VN ---------------PILMAHGNISPSAYVLETFKGIRSSELEEALLVLPFSYVPDVLTL FNEFIQTGL--------------------------------------------------- ----------------------------DVELLCRCLFFLLRIHFGQITSNQMLVPVIEK LKETTISKVRQVQDAIGFNMAGLDYLKRECEAKSEVMFFAEATSHLEEKKKKRKNRKRMI LTLT-------------------------------------------------------- ----------------------------- >H_sapiens_ENSP00000262715 -MEKLHGHVSAHPDILSLENRCLAMLPDLQPLEKLHQHVSTHSDILSLKNQCLATLPDLK TMEKPHGYVSAHPDILSLENQCLATLSDLKTMEKPHGHVSAHPDILSLENRCLATLSSLK STVSASPLFQSLQISHMTQADLYRVNNSNCLLSEPPSWRAQHFSKGLDLSTCPIALKS-I SATETAQEATLGRWFDSEEKK------GAETQMPSYSLSLG-EEEE-VEDLAVKLTSGDS ESHPEPTDHVLQEKKMALLSLLCSTLVSEVNMNNTSDPTLAAIFEICRELALLEPEFILK ASLYARQQLNVRNVANNILAIAAFLPACRPHLRRYFCAIVQLPSDWIQVAELYQSLAEGD KNKLVPLPACLRTAMTDKFAQFDEYQLAKYNPRKHRAKRHPRRPPRSPGMEPPFS--HRC FPRYI-GFLREEQ-RKFEKAGDTVSEKKNPPRFTLKKLVQRLHIHKPAQHVQALLGYRYP SNLQLFSRSRLPGPWDSSRAGKRMKLSRPETWERELSLRGNKASVWEELIENGKLPFMAM LRNLCNLLRVGISSRHHELILQRLQHAKSVIHSRQFPFRFLNAHDAIDALEAQLRNQALP FPSNITLMRRILTRNEKNRPRRRF---LCHLSRQQLRMAMRIPVLYEQLKREKLRVHKAR QWKYDGEMLNRYRQALETAVNLSVKHSLPLLPGRTVLVYLTDANADRLCPKSNPQGPPLN YALLLIGMMITRAEQVDVVLCGGDTLKTAVLKAEEGILKTAIKLQAQVQEF--DEN-DGW SLNTFGKYLLSLAGQRVPVDRVILLGQSMDDGMINVAKQLYWQRVNSKCLFVGILLRRVQ YLST--DLNPNDVTLSGCTDAILKFIAEHGASHLLEHVGQMDKIFKIPPPPGKTGVQSLR PLEEDTPSPLAPVSQQGWRSIRLFISSTFRDMHGERDLLLRSVLPALQARAAPHRISLHG IDLRWGVTEEETRRNRQLEVCLGE----------VENAQLFVGILGSRYGYIPPSYNLPD HPHFHW----------------AQQYPSGRSVTEMEVMQFLNRNQRLQPSAQALIYFRDS SFLSSVPDAWKSDF---------------------------------------------V SESEE-------------------------------AARRISELKSYLSRQKGITCRRYP CEWGGVAAGR---PY--VGGLEEFGQLVLQDVWNMIQKLYLQPGALLEQPVSIPDDDL-- --------------VQATFQQLQKPPSPARPRLLQDTVQRLMLP------HGRLSLVTGQ SGQGKTAFLASLVSALQAPDGAKVASLVFFHFSGARPDQGLALTLLRRLCTYLRGQLKEP -GALPS-TYRSLVWELQQRLLPKSAESLHPGQTQVLIIDGADRL--VDQNGQLISDWIPK KLPRCVH----LVLSVSSDAGLGETLEQSQGAHVLALGPLEASARARLVREELALYGKRL EESPFNN-------------QMRLLLVKRESGRPLYLRLVTDHLRLFTLYEQVSERLRTL PAT-----VPLLLQHILSTLEKEHGPDVLPQALTALEVTRSGLTV--DQLHGVLSVWRTL P-KGTKSWEEAVAAGNSGDPYPMGPFACLVQSLRSLLGE-----G-PLERPGARLCLPDG PLRTAAKRCYGKRPGLEDTAHILIAAQLWKTCDADASGTFRSCPPEALGDLPYHLLQSGN RGLLSKF-LTNLHVVAAHLELGLVSRLLEAHALYASSVPKEEQKLPEADVAVFRTFLRQQ ASILSQYP-RLLPQQ-----------AANQPLDSPLCHQASLL---SRRWHLQHTLRWLN KPRTMKNQQS---SSLSLA-----VSSSPTAVAFSTNGQRAAVGTAN---GTVYLLDLR- TWQEEKSVVS-GCDGISACLFL---SDDTLFLTAFDGLLELWDLQHGCRVLQTKA-HQYQ ITGCCLSP-D---CRLLATVCLGGC--LK----LWDTVRGQLAFQHT-YPKSLN--CVAF ------HPEGQVIATGSWAGSISFFQVDG--LKV-------------------------- ----------------------------TKDLGAPG--ASIRTLAFNVPGGVVAVGRLDS MVELWAWREGARLAAFPAHHG---------------------FVAAALFLHAGCQLLTAG EDGKV--------QVWSGSLGRPRGHL-GSLSLSPALSVALSPDGDRVAVGYRADGIRIY KISSGS---------QGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECSLQSL WLLSRFQKPVLGLATSQE--LLASAS-EDFTVQLWP-RQLLTRPHKA------------- -------------------EDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWD VRTPKTPVLIHSFPACHRDWVTGCAW----TKD--NLLISCSSDGSVGL-WDP----ESG QRLGQFLGHQSAVSAVAAVEE----HVVSVSRDGTL----KVWDH-Q--GVELTSIPAHS G-PISHCAAAMEPRAAGQPGSELLVVTVGLDG----ATRLWHPL---LVCQTH-TLLGHS GPVRAAAVSET-SGLMLTASED-GSVRLWQVPKEADDTCI---------PRSSAAVTAVA WAPDGSMAVSGNQAGELI--LWQEAK--AVATAQAPGH-IGALIWSSAHTFFVLSADEKI SEW--------------------QVKLRKGSAPGNLSLHLNRIL--QE------------ -------DLGVLTSLDWAPDGHFLILAKADLKLLCMKPGDAPSEIWSSYTENPMIL-STH ---------------KEYGIFVLQPKDPGVLSFLRQKESGEFEERLNFDINLENPSRTLI SITQAKPES---------ESSFLCASSDGILWNLAKCSPEGEWTTGNMWQKKANTPETQT PGTDPSTCRESDASMDSDASMDSEP-TPHLKTRQRRKIHSGSVTALHVLPELLVTASKDR DVKLWERPSMQLLGLFRCEGSVSCLEPWLGANSTLQLAVGDVQGNVYFLNWE-------- ------------------------------------------------------------ ----------------------------- >T_rubripes_ENSTRUP00000017221 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MANPHLHFKTNYAVSSKIEPF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------YKGGKVQI--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SKD ENYIFCTCGSRINVLEISTGKIVHS----------------------------------- ------------------------------------------------------------ ---------------VEHD-----DQEDITSFALSSDDELLVTASRA---LLLKQWDWR- QAQCTRSWRAIHTAPVASMDFD--STSTLLATGGCDGTIKIWDVVKQYCTHNLRG-SSGV VHLVQFHP-DIS-RLKLFSSSMDCS--IW----MWDLSTSLCVCMLQSHYSAVT--SLSF ------SPDGDTMISSGRDKICTVWDLKQ--QNA-------------------------- -----------------KRAIPVYEAVEGVIFLPEN--QDFSQIGVKNPKLHFVTAGSKG ILRVWDPNTARCVFSQTLGTVSVKKDDEEGEEEEKKDDNPR-SLTHLLLLPASSRLATVT AEHNI--------TLYQLAGLTTLQQF-VGYNDEVLDVKFLGKDDSHIVVATNSCQLKVF ELLTNS-----------------------------------------------------C QILYGHTDTVLSLDVFRKGSLFASCA-KDRSVCVWQ------------------------ ---------------------------M--DSGHVRC----------------------- ----------VARGTSHTNAVGCISC----SRMKASFVASGSLDCTVKV-WDL----PAD LTAAE------E----------------------------SIQQL-----TLRTTEKAHD K-DVNSVAVS----PNDK-----LLASASQDR----TAKLWSLAGEGNLGLLG-VFRGHR RGVWTVCFSPV-DQVLATSSAD-GTTKLWSLQDFSCLKTF---------EGHDASVLKVI FVSRGTQLLTSGSDGLVK--LWTIKTNECVKTLDAHQDKVWGLHGNRRDNRMVTGSADSN ITV--------------------WEDVTEMEVAEEQAKQEEQILKQQEL----------- -------SNLLQEKKYLKALGLAISLDQPHTVLTVIKAIRQTEDSS-------------- ---------------------------------------ELLEKTVLKLRVDQKEALLRY CGVWNTNAK--------------------------------------------------- -----------------------------------------NCQDAQVVLQVLLTHVPPE ELLQYQGARTHLEGLVPYTERHMQRIGRLLQASMFLNYMWQKMRVVGEPSSMDQDEEMDT SPLVQPFFTIDKDSE-ESSEEEDMDEEEEEAGKAAKRL---------------------- ----------------------------- >C_intestinalis_ENSCINP00000019387 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------LQLRTKYDLIKKWEPF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------FTGGRVEV--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SNS ENYLLCVCGDKIKIVNVDSGLVEKE----------------------------------- ------------------------------------------------------------ ---------------LSHD-----G-DDVTCLAVSPDDSMIVTSTKS---LLLKQWEWKM EVKCVRTWRAIHMFPVVSMDFD--PTSTLLATGGSDGTIKVWDMIRQYCTHNFRG-SPGI VNCVAFHP-N---NLTLYSAADDYN--IR----VWDLNSSKLVKVLNSHVSSVT--CLKF ------S-NVDCLVSAGRDNVVCLWNVKEGGNEP-------------------------- -----------------YKVIPVFESVEACFNFERK--EN-------ETGFLIITAGSKG QLRVWESSNGKCVFTNP----------------DNDSNVAS-GYIHAKLIPDTNKMVAVT FDHCI--------DCLDMNGLVVNKQM-VGYNDEIVDLKLLGKNDSHIIVVTNSPHIKVF NMKTSA-----------------------------------------------------C QVLKKHSDTVLCVDVFKNRTHFVSSS-KDNTVCLWR------------------------ ---------------------------MEENTYAVTC----------------------- ----------LVVGAGHTHDVGAVTC----CNNKMEFLVSGSQDQTLKI-WTI----NET F------------------------------------------QL-----RVKHTVMAHS K-NINSIVVS----PNDK-----LIASGSQDK----LAKLWKVS---DGSVVG-TFKGHK RGIWCVQFSPM-DQVLATSSAD-GSIKLWSLSDFTCLKTL---------EGHDCSVLKVI FIAKGTQMVSCGSDGLLK--LWTIKLSECIQTVEAHDEKAWALCSDVEDTMIISGGADSI ISF--------------------WKDVTDEQRREDIEAKQKTMLHHQEL----------- -------QNLLQEKKYEKALHFAIKLSQPFTALNVIKELMWETDGY-------------- ---------------------------------------DFLNKYLSILRLDQKSELLKF VVSWNTNSR--------------------------------------------------- -----------------------------------------NCHEAHAVLKALLSNTAPE DFEQIENYQSVIESLLPYTERHFHRMNKISQQATFVDYTWQLIKMK-------------- ------------------------------------------------------------ ----------------------------- >G_gallus_ENSGALP00000023833 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MGLTRQYLRYAPAALF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GLVGSARGNPAFVTLR------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GER GRCVAVPACEHVFVWDARKGEKVL------------------------------------ ------------------------------------------------------------ ---------------ILKG-----SKHE-SCLRPSPDGLHLAVGYED---GSIRIFSLL- SGEASVAFNG-HKAAVTALQYD--QLGGRLVSGSKDTDVIVWDVINESGLYRLKG-HKDA VTQVLFLK-E---KNLLVTSGKDTL--VK----WWDLDTQHCFKTLVGHRTEVW--GMAL ------VSEEKRLITGTADSELRVWDITY--IQE--LEDPDE--PESKKSKG-SSPGAEK D---NEEDETLEL-DESPEERLLKCSKAGSIMREGR--DRVVTLATDRMGKILACHGTDA VLEVFSVLSEEEIKKKLDK-----------------------KMKKAKKKAKKKS----- EEDEHKG----NVELSLQEEIQRVTNIRASAKIKSFDMILSPKEELKIVLLLQNNIIELY TLNLSA---------QVP----QAVRASRIT----------------------------- --IGGHRSDVRTLAFSSDNIAVLSGA--AESVKIWN-RSTLQCIRTM------------- ------------------------------DCEYALCSLFVPGDRQVIVGTKTGKLQLYD LASG----TLMETLNAHDGAVWSIAL----SPDQRGF-VTGGADKCVKF-WDF----ELV KDESSI-Q--------------------------------KRLSM------KQVRILQLD E-DVLCVRYS----PNQK-----LLAVSLLDC----TVKVFYTD---TLKFFL-SLYGHK LPVLCMDISYD-GALIATGSAD-RNVKIWGLDFGDCHRSL---------FAHDDSVMYLQ FVAKSHLFFTAGKDNKIK--QWDADKFEHIQTLEGHHQEVWCLALSPNGDYVVSASHDKS LRL--------------------WERTREPLILEEEREMQREAEYEESVAKEEQPVVAGE TQG----ETGLAGKKTIETIKAAERIMEAIELYREEMAKLKEHKAICKAAGKEVPFP-AN ---------------PILRAYGNITPSEYVLEVFKKVKSSELEESLLVLPFSYVPDLLRL FNEYIQLGA--------------------------------------------------- ----------------------------EIELLCRALLFLLKIHFGQITGNQMLVTVIEN LKKTTISRVSEARDVLGFNMAGLQYLKREIEAKDEVMFFADATDRFEEKKRKRKKKEKMI LAVV-------------------------------------------------------- ----------------------------- >P_troglodytes_ENSPTRP00000010340 -MEKLHGHVSAHPDILSLENRCLAMLPDLQPLEKLHQHVSTHSDILSLKNQCLATLPDLK TMEKPHGYVSAHPDILSLENRCLATLSDLKTMEKPHGHVSAHPDILSLENRCLATLPSLK STVSASPLFQSLQISHMTQADLYRVNNSNCLLSQPPSWRAQHFSKGLDLSTCPIALKS-I SATETAQEATLGRWFDSEEKK------GAETQMPSYSLSLG-EEEE-VEDLAVKLTSGDS ESHPEPTDRVLQEKKMALLSLLCSTLVSEVNVNNTSDPTLAAIFEICRELALLEPEFILK ASLYARQQLNVRNVANKILAIAAFLPACRPHLRRYFCAIVQLPSDWIQVAELYQSLAEGD KNKLVPLPACLRTAMTDKFAQFDEYQLAKYNPRKHRAKRHPHRPPRSPRMEPPFS--HRR FPRHI-GFLREEQ-RKFEKAGDTVSEKKNPPRFTLKKLVQRLHIHKPAQHVQALLGYRYP SNLQLFSRSRLPGPWDSSRAGKRMKLSRPETWERELSLRGNKASVWEELIENGKLPFMAM LRNLCNLLRVGISSRHHELILQRLQHAKSVIHSRQFPFRFLNAHDAIDALEAQLRNHALP FPSNITLMRRILTRNEKNRPRRRF---LYHLSRQQLRMAMRIPVLYEQLKREKLRVHKAR QWKYDGEMLNRYRQALETAMNLSVKHSLPLLPGRTVLVYLIDANADRLCPKSNPQGPPLN YALLLIGMMITRAEQVDVVLCGGDTLKTAVLKAEEGILKTAIKLQAQVQEF--DEN-DGW SLNTFGKYLLSLAGQRVPVDRVILLGQSMDDGMINVAKQLYWQRVNSKCLFVGILLRRVQ YLST--DLNPNDVTLSGCTDAILKFIAEHGASHLLEHVGQMDKIFKIPPPPGKTGVQSLR PLEEDTPSPLASISQQGWRSIRLFISSTFRDMHGERDLLLRSVLPALQARAAPHRISLHG IDLRWGVTEEETRRNRQLEVCLGE----------VENAQLFVGILGSRYGYVPPSYNLPD HPHFHW----------------AQQYPSGRSVTEMEVMQFLNRNQCLQPSAQALIYFRDS SFLSSVPDAWKSDF---------------------------------------------V SESEE-------------------------------AACRISELKSYLSRQKGITCRRYP CEWGGVAAGR---PY--VGGLEEFGQLVLQDVWNMIQKLYLQPGALLEQPVSIPDDDL-- --------------VQATFQQLQKPPSPARPRLLQDTVQQLMLH------HGRLSLVTGQ SGQGKTAFLASLVSALQAPDGAKVAPLVFFHFSGARPDQGLALTLLRRLCTYLRGQLKEP -GALPS-TYQSLVWELQQRLLPKSAESLHPGQTQVLIIDGADRL--VDQNGQLISDWIPK KLPRCVH----LVLSVSSDAGLGETLEQSQGAHVLALGPLEASARARLVREELALYGKRL EESPFNN-------------QMRLLLVKRESGRPLYLRLVTDHLRLFTLYEQVSERLRTL PAT-----VPLLLQHILSTLEKEHGPDVLPQALTALEVTRSGLTV--DQLHGVLSVWRTL P-KGTKSWEEAVAAGNSGDPYPMGPFAYLVQSLRSLL-E-----G-PLERPGARLCLPDG PLRTAAKRRYGKRPGLEDTAHILIAAQLWKTCDADASGTFRSCPPEALGDLPYHLLQSGN RGLLSKF-LTNLHVVAAHLELGLVSRLLEAHALYASSVPKEEQKLPEADVAVFHTFLRQQ ASILSQYP-RLLPQQ-----------AANQPLDSPLCHQAPLL---SQRWHLQHTLRWLN KPQTMKNQQS---SSLSLA-----VSSSPTAVAFSTNGQRAAVGTAN---GTVYLLDLR- TWQEEKSVVS-GCDGISACLFL---SDDTLFLTAFDGLLELWDLQHGCRVLQTKA-HQYQ ITGCCLSP-D---CRLLATVCLGGC--LK----LWDTVRGQLAFQHT-YPKSLN--CVAF ------HPEGQVIATGSWAGSISFFQVDG--LKV-------------------------- ----------------------------TKDLGAPG--ASIRTLAFNVPGGVVAVGRLDS MVELWAWREGARLAAFPAHHG---------------------FVAAALFLHAGCQLLTAG EDGKV--------QVWSGSLGRPRGHL-GSLSLSPALSVALSPDGDRVAVGYRADGIRIY KISSGS---------QGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECSLQSL WLLSRFQKPVLGLATSQE--LLASAS-EDFTVQLWP-RQLLMRPHKA------------- -------------------EDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWD VRTPKTPVLIHSFPACHRDWVTGCAW----TKD--NLLISCSSDGSVGL-WDP----ESG QRLGQFLGHQSAVSAVAAVEE----HVVSVSRDGTL----KVWDH-Q--GVELTSIPAHS G-PISHCAAAMEPRAAGQPGSELLVVTIGLDG----ATRLWHPL---LVCQTH-TLLGHS GPVRAAAVSET-SGLMLTASED-GSVRLWQVPKEADDTCI---------PRSSAAVTAVA WAPDGSMAVSGNQAGELI--LWQEAK--AVATAQAPGH-IGALIWSSAHTFFVLSADEKI SEW--------------------QVKLRKGSAPGNLSLHLNRIL--QE------------ -------DLGVLTSLDWAPDGHFLILAKADLKLLCMKPGDAPSEIWSNYTENPMIL-STH ---------------KEYGIFVLQPKDPGVLSFLRQKESGEFEERLNFDINLENPSRTLI SITQAKPES---------ESSFLCASSDGMLWNLAKCSPEGEWTTGNIWQKKANTPETQT PGTDPSTCWESDASMDSHASMDSEP-TPHLKTRQRRKIHSGSVTALHVLPELLVTASKDR DVKLWERPSMQLLGLFRCEGSVSCLEPWLGANSTLQLAVGDVQGNVYFLNWE-------- ------------------------------------------------------------ ----------------------------- >T_guttata_ENSTGUP00000013749 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MGLTRQYLRYEPAALF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GLVASARAGVAFVALR------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GER GRYVAVPACEHVFVWDTRKGEKVL------------------------------------ ------------------------------------------------------------ ---------------ILKG-----LKQQVSCLCPSPDGLHLAVGYED---GAIRVFNLL- SGESTITFNG-HRAAVTALQYD--HLGGRLVSGSKDTEVIVWDVINESGLYRLRG-HKDV ITQVLFLK-E---KNLLITCAKDTL--VK----WWDLDTQHCFKTLVGHRAEVW--GMAL ------LSKEKRLITGSADSELRVWDLTY--IQE--VKDHDE--PESKKSKGSSSPGAEE N---NEEDETLEV-DEHPEERIVKCSKVGSIMREGR--DRVVTLGTDRMGKFLAVHGTDT VLEVFSVLSEEEIQKKLGK-----------------------KLKKARKKAKQNS----- -EEEPER----SVELSLQEEIQRVTNVKASSKIKSFDLILSPKGELKMVLLLQNNIIELY NLDLSA---------QVT----QAVRVSRIT----------------------------- --IGGHRSDVRTLAFSSDNIAILSAA--AESVKIWN-RSTLQCIRTM------------- ------------------------------ECEYALCSLFVPGDRQVIIGTKTGKLQLYD XXXX----XXXETLDAHDGAVWSIAL----SPDQHGF-VTGGADKCVKF-WEF----ELV KDESSV-Q--------------------------------KRLSM------KHVRVLQLD E-DVLCVRYS----PNQK-----LLAVSLLDC----TVKVFYVD---TLKFFL-SLYGHK LPVLCMDICYD-GTLIATGSAD-RNVKIWGLDFGDCHRSL---------FAHDDSVMYLQ FVPKSHLFFTAGKDSKIK--QWDADKFEHIQTLEGHHQEVWCLALSPNGDYVVSASHDKS LRL--------------------WERTREPLILEEEREMQREAEYEESVAKEEQPVVPGE RQG----ETGLAGKKTIETIKAAERIMEAIELYREETAKLKEHNAICKAAGKEVPFP-VN ---------------PILRAYGNITPSAYVLEVFKKVKSSELEESLLVLPFSYVPDLLRL FNEYIQQGS--------------------------------------------------- ----------------------------DVELLCRALLFLLKIHFGQITGNQMLVTVIEN LKKTAISRVSEARDVLGFNMAGLQFLKREIEAKEEVTFFADATERFEEKKRKRKKKEKMV LAVL-------------------------------------------------------- ----------------------------- >T_rubripes_ENSTRUP00000006345 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MGLTKQYLRYVASAVF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GVIGSQKANIAYVTLRG------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GEK GRYIAAAACEHVFIWDVRKGEKVM------------------------------------ ------------------------------------------------------------ ---------------ILEG-----QKHEVTFLRPSPDGVSIAVGYED---GAVRIFSLL- NGESNVSFNG-HKSAVSIICYD--ELGARLVTGSKDTDVIVWDIINECGLYRLRG-HKGL ITQALFLK-D---KNLLVTSSKDSF--VK----WWDLDTQHCFKTIVGHRSEVW--GMVL ------LDRESRLLTGSADSELRAWDITY--LQE--VKAEGE--PEEKRGKI---ELVED EDEGDQED---EA-DEGPEERILSCKKVGSILREAR--DRVVSLAADARTGVIACHGNDS ILEVFRVLPEAEVQQKMKK-----------------------KEKRARKKAARAQ--EET GEDAGEL----TVKRTLKDEITRLTHIKASAKIRWAECLSCPGGELKVALLLQNNTIETY SLKAAS---------TTP----TSNKTARLT----------------------------- --LGGHRTDVRTLAFSSDNLAVLSAS--GDTIKVWN-RATLQVIRTM------------- ------------------------------ACEYALCSLFVPGDRQIILGTKSGKLQIFE LASG----SLLETVDAHDGALWSLCL----APDQRGL-VTGSADKTVKF-WEF----ELI KDGEMS-H--------------------------------KRLTV------KHKRTLQLE E-DVLCVKFS----PDHR-----LLAVSLLDC----TVKLFYTD---TLKFFL-SLYGHK LPVLCLDICHD-STLIATGSAD-RNVKIWGLDFGDCHRSM---------FAHDDSVMFLQ FLPKTHLFFTAGKDKKIK--QWDADKFEHIQTLEGHHREVWCLAVSPSGDHLVSASHDKS LRL--------------------WERTREPVILEEEREMEREAEFEESMSKGDIPVVPGE APG----EAAPAGKKTIETVKAAERIMEALELFKDENRKMEEHKYVCEAAGKQLPPPNPN ---------------PILVAFGNISPSRYVLDVIRKVRSSELEVSLLVLPFSYVPELLKL FNGYIQQGL--------------------------------------------------- ----------------------------EVELVCRCLFFLLRIHFGQISSNQMLLTVMDQ LRTNTVAQVRQIRDVMGFNSAALQFLQREIESREEVTFFAEATGKLKERKRRRTKRERVV LTIA-------------------------------------------------------- ----------------------------- >H_sapiens_ENSP00000308179 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MGLTKQYLRYVASAVF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GVIGSQKGNIVFVTLR------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GEK GRYVAVPACEHVFIWDLRKGEKIL------------------------------------ ------------------------------------------------------------ ---------------ILQG-----LKQEVTCLCPSPDGLHLAVGYED---GSIRIFSLL- SGEGNVTFNG-HKAAITTLKYD--QLGGRLASGSKDTDIIVWDVINESGLYRLKG-HKDA ITQALFLR-E---KNLLVTSGKDTM--VK----WWDLDTQHCFKTMVGHRTEVW--GLVL ------LSEEKRLITGASDSELRVWDIAY--LQE--IEDPEE--PDPKKIKG-SSPGIQD TL--EAEDGAFET-DEAPEDRILSCRKAGSIMREGR--DRVVNLAVDKTGRILACHGTDS VLELFCILSKKEIQKKMDK-----------------------KMKKARKKAKLHS--SKG EEEDPEV----NVEMSLQDEIQRVTNIKTSAKIKSFDLIHSPHGELKAVFLLQNNLVELY SLNPSL---------PTP----QPVRTSRIT----------------------------- --IGGHRSDVRTLSFSSDNIAVLSAA--ADSIKIWN-RSTLQCIRTM------------- ------------------------------TCEYALCSFFVPGDRQVVIGTKTGKLQLYD LASG----NLLETIDAHDGALWSMSL----SPDQRGF-VTGGADKSVKF-WDF----ELV KDENST-Q--------------------------------KRLSV------KQTRTLQLD E-DVLCVSYS----PNQK-----LLAVSLLDC----TVKIFYVD---TLKFFL-SLYGHK LPVICMDISHD-GALIATGSAD-RNVKIWGLDFGDCHKSL---------FAHDDSVMYLQ FVPKSHLFFTAGKDHKIK--QWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKS LRL--------------------WERTREPLILEEEREMEREAEYEESVAKEDQPAVPGE TQG----DSYFTGKKTIETVKAAERIMEAIELYREETAKMKEHKAICKAAGKEVPLP-SN ---------------PILMAYGSISPSAYVLEIFKGIKSSELEESLLVLPFSYVPDILKL FNEFIQLGS--------------------------------------------------- ----------------------------DVELICRCLFFLLRIHFGQITSNQMLVPVIEK LRETTISKVSQVRDVIGFNMAGLDYLKRECEAKSEVMFFADATSHLEEKKRKRKKREKLI LTLT-------------------------------------------------------- ----------------------------- >R_norvegicus_ENSRNOP00000012235 -MEKLCGYVPVHPDILSLKNRCLTMLSDIQPLEKIHGQRSVNPDILSLENRCLTLLPDLQ PMEKIHGQRSVHPDILSSENRCLTLLPDLQSLEKLCGHMSSHPDVLSLENRCLATLPTVK RTVSSGPLLQCLHRSHTAQADLRDPNFRNCLFPEPPTIEAPCFLKELDLPTGPRALKS-M SATARVQEVALGQRCVSEGKELQEEKESAEVPMPLYSLSLGGEEEEVVGAPVLKLTSGDS DSHPETTDQILQEKKMALLTLLCSAMASSVNVKDASDPTRASIHEVCSALAPLEPEFILK ASLYARQQLNLRDIANIVLAVAALLPACRPHVRRYYSAIVHLPSDWIQVAEFYQSLAEGD EKKLVPLPACLRAAMTDKFAQFDEYQLAKYNPRKHRSKTRSRQPPRPQRTKPPFSESGKC FPKSV-WPLKNEQ-ISFEAAYNAVSEKKRLPRFTLKKLVEQLHIHEPAQHVQALLGYRYP STLELFSRSHLPGPWDSSRAGQRMKLQRPETWERELSLRGNRASVWEELIDNGKLPFMAM LRNLCNLLRTGISAHHHELVLQRLQHEKSVIHSRQFPFRFLNAHDSLDRLEAQLRSKASP FPSNTTLMKRIMIRNSKKIKRPANPRYLCTLTQRQLRAAMAIPVMYEHLKREKLRLHKAR QWTCDLELLERYRQALETAVNISVKHNLPPLPGRTLLVYLTDANANRLCPKSHLQGPPLN YVLLLIGMMMARAEQTTVWLCGTGTVKTPVLTADEGILKTAIKLQAQVQEL--EEN-DEW PLETFEKYLLSLAVRRTPIDRVILFGQRMDTELLNVAKQIIWQHVNSKCLFVSVLLRKMQ YIDPYFLSAPAKVSIGSCSCMSLLFIAEHGASRLLEHVGQLDKIFKIPPPPGKTKVSPLR PLEENNPGPFVPISQHGWRNIRLFISSTFRDMHGERDLLMRSVLPALQARAFPHRISLHA IDLRWGITEEETRRNRQLEVCLGE----------VENSQLFVGILGSRYGYTPPSYDLPD HPHFHW----------------TQRYPSGRSVTEMEVMQFLNRGQRSEPSDQALIYFRDP GFLSSVPDVWKPDF---------------------------------------------I SESEE-------------------------------AAHRVSELKRFLQEQKEVTCRRYS CEWGGVAAGR---PY--TGGLEEFGQLVLQDVWSVIQKRYLQPGAQLEQPGSISEEDL-- --------------IQASFQQLKSPPSPARPRLLQDTVQQLMLP------HGRLSLVIGQ AGQGKTAFLASLVSALKVPDQPNVAPFVFFHFSAARPDQCLAFNLLRRLCTHLHQKLGEP -SALPS-TYRCLVWELQQKLLLKSAQWLQPGQTLVLIIDGADKL--VDHNGQLISDWIPK SLPRRVH----LVLSVSSDSGLGETLQQSQSAYVVALGSLVPSSRAQLVREELALYGKRL EESPFNN-------------QMRLLLAKQGSSLPLYLHLVTDYLRLFTLYEQVSERLRTL PAT-----LPLLLQHILSTLEQEHGHNVLPQALTALEVTHSGLTV--DQLHAVLSTWLTL P-KETKSWEEAVAASHSGNLYPLAPFAYLVQSLRSLLGE-----G-PVERPGARLCLSDG PLRTAVKRRYGKRLGLEKTAHVLIAAHLWKMCDPDASGTFRSCPPEALKDLPYHLLQSGN HGLLAKF-LTNLHVVAAYLEVGLVPDLLEAYELYASSKPEVNQKLPEADVAVFHNFLKQQ ASLLTQYP-LLLLQQ-----------AASQPEESPVCCQAPLL---TQRWHNQCILKWIN KPQTLKGQQ-----SLSLP-----ISSSPTAVAFSPNGQRAAVGTAG---GTIYLLNLR- TWQEEKALVS-GCDGISSFAFL---SDTALFLTTFDGLLELWDLQHGCWVFQTKA-HQYQ ITGCCLSP-D---RRLLATVCLGGY--VK----LWDTVQGQLAFQYT-HPKSLN--CITF ------HPEGQVVATGNWSGIVTFFQADG--LKV-------------------------- ----------------------------TKELGGPG--PSVRTLAFSAPGKVVALGRIDG TVELWAWQEGTRLAAFPAQCG---------------------GVSTVLFLHAGGRFLTAG EDGKA--------QLWSGFLGRPRGCL-GSLYLSPALSVALNPDGDQVAVGYRGDGIKIY RISSGP---------QEAQCQELNVAVSALVWLSPSVLVSGAEDGSLHGWMLRRNSLQSL WLSSVCQKPVLGLAASQE--FLASAS-EDFTVRLWP-RQLLTQPHAV------------- -------------------EELPCAAELRGHEGPVCCCSFSPDGRILATAGRDRNLLCWD VKVAQAPLLIHTFSSCHRDWITGCTW----TKD--NILISCSSDGSVGL-WNP----EAG QQLGQFPGHQSAVSAVVAVEE----HIVSVSRDGTL----KVWDR-Q--GVELTSIPAHS G-PISQCAAALEPRPAGQPGSELLVVTVGLDG----ATKLWHPL---LVCQIH-TLQGHS GPVTAAAASEA-SGLLLT-SDN-SSVRLWQIPKEADDTCK---------PRSSAVITAVA WAPDGSLVVSGNEAGELT--LWQKAQ--AVATARAPGR-VSDLIWCSANAFFVLSANENV SEW--------------------QVELRKGSTCTNFRLYLKRVL--QE------------ -------DLGVLTGMALAPDGQSLILMKEDVELLQMKPGSTPSSICRRYAVHSSIL-CTS ---------------KDYGLFYLQQGNSGSLSILEQEESGKFEKTLDFNLNLNNPNGSPV SITQAEPES---------GSSLLCATSDGMLWNLSECTPEGEWVVDNIWQKKSRNPKSRT PGTDSSPGL---------FCMDSWVEPTHLKARQCKKIHLGSVTALHVLPGLLVTASEDR DVKLWERPSMQLLGLFRCEGPVSCLEPWMEPSSPLQLAVGDAQGNLYFLSWE-------- ------------------------------------------------------------ ----------------------------- >D_melanogaster_FBpp0085899 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------MAAPIDES VLNALRGVTSAHTRLPKPLLIKIYVASLKQEFNQERRMLLELVGPELQSLYDDRQIELEF VDMHFGTGDLEVHQLERDPYLIHDYLHEIDTCHAHTKSVFFMVLVGDGIGRQLLPTKIDE DIFSAVLADQQTSADHEAMLVKWYERDASQTQRQLKQDYRLMNVDAWLAESQRMQSFLEQ AFQSLLQGSGASGRS---------------------PDFMERVQLLRRTQIEREVSQAMA LTSEKILAVFRERAAQCSKGDVEAAE----------RLRKIKDELTMNLSTDNHTTLVVP GSAASEAIDPDNEDH--ESYLSKFKNKVTDKLRLLIEAHITNDPDVIKGRKKTVQEIFHE H------------ATHLRILREHTDSDALVESRVPQQLRQNLMANFRNGSRHAPYFLCGA DGSGKSAILCHLYGQVGSWFGSTRVHRVIR-FAKATPRSAYNLELLRVICQQISIIFNIP EGYLPKDASFDPLYINTWFQNLLRRVEDMGNDVLFLFIDDLHLLNPLDCDIVTALSWLPT SLPWNVQ----IICSSTTPVEQLKFTPMQRDRFKSIEYQFDLNMGDYATKLKI------- ---PPQC-------------------IPGDVSFALYVEQQFDQLERHYGRQAVGDLASYI TCSEYGLSETELLELLMPTDDPESLIETKNGHFSFATFKKIHREMDLLLLLHDKIMSGKV LIQWRHNYCASVAKRRYMDVQRTRSLHCELANLFFPQDEDESTLENESNRSESKSVISLK DRDREKDSLSAVSAVSAGRKSSSTHHNDDTSTFYNPIAADVSYSMRHVEESWHHLMRSDD TTRFKQIAVCNFDFLLAAVQTVSISYLRCLIEHVRCYILDRD-------IELIYYTIRKS SDVLTRDPMQLGSQLISWLRPISEHDDDDNSLLSMTVRSATAWCDGYAVPLLVPLTGWLP APLPSQIRT------MTVS-----GTGCIRAVWLAPSKQHLILATSS---GDVQQWHIM- SNSLDHIFKG-HTAAVTCLLVAPQSDSELLLTGSEDATVLVWHVGLRERRAHIKNAHTAP ITGVAAGA-N---NTLIISSSEDAS--IA----ITDLASGKLRHRITHHRGPVS--GIVV ------AGACDVLISGGLDRTICVWDLDN--FTL-------------------------- -----------------LNTMQMT--------------SAVLRIDISWNSVFLLALCEDN ALYVRTLATGKELHTLKGHKS---------------------KIRSISIGKDSQRCVVGC DDTRA--------LIYDMHAGKLVRSL-PPNPGPVTAVHAMDNDDFLVTVG--GNKITFY SFRNEELYVNPYSRHPRRKRSLKRHAQAQRS----------------------------- --PSTTLPPITCFDLSRDSQQMAIAS--GRHVHLMR------------------------ ------------------INTPEYQCTLEGHTAGVSCLKFAPNGEFLATGSEDRLVHIWN LALG----EICNSFKGHTAPVVKVVV----LMDSLRV-ISTDRDSMLLV-WMA----HSG NLLQTIQGPYKSLSVTNNMR-----FAVSTNGDNTL----KIWSLTQ---EDEKYSVSHS D-EITCFEIS----ADSV-----HIISGSRDM----SLKVWQAT---GGKLSQ-VLVGHS DAVTCVAVSVTNKTQVLSGSKD-MNLILWDLLTGEEVHTL---------AGHLGPVIGVK VSADGSTAVSGSDDKTLI--VWETKRGLALTSLQMHVPFTHFDISLEVSRVLVQLVDSYN LPVICLHNTPAQYVKLP-TYSGPSKDVEDLRPQGPKRQMKRLLKKEVSL----------- -------DTYTWQKKY-GHLTSSVMMAQVDERLKRRFSVSASMEEISKIAETKTGASQAN LGPEQAALAQSQHFDQLEALWNKRSPPRRRHNAGLSRQTSLVEDRLESSDDDEYQDERAG MLSASYDNIHHLARLPGLRSLHDAWKTNSLRVPSRSARTKFYVSTPPPQNSQNSSSLRLD SHVPGQFTDGVVAPDLVRDLLSVPPTVESPQR--------------ISLRQLLHWPSLKS RIWRRQRNC---QSLQPNIRLNPPERLRPTPIIVVENYDVRRVQQLRTDLILHPQTSRAS VGHIEVAGSEHLLAKKANYWQRRWHLLRHKAASTTTTTTSRSESSHPHRDSMNSHSNNST PDPTANCNDCVAQ---------------- >P_troglodytes_ENSPTRP00000001997 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MGLTKQYLRYVASAVF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GVIGSQKGNIVFVTLR------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GEK GRYVAVPACEHVFIWDLRKGEKIL------------------------------------ ------------------------------------------------------------ ---------------ILQG-----LKQEVTCLCPSPDGLHLAVGYED---GSIRIFSLL- SGEGNVTFNG-HKAAITTLKYD--QLGGRLASGSKDTDIIVWDVINESGLYRLKG-HKDA ITQALFLR-E---KNLLVTSGKDTM--VK----WWDLDTQHCFKTMVGHRTEVW--GLVL ------LSEEKRLITGASDSELRVWDIAY--LQE--IEDPEE--PDPKKIKG-SSPGIQD TL--EAEDGAFET-DEAPEDRILSCRKAGSIMREGR--DRVVNLGVDKTGRILACHGTDS VLELFCILSKKEIQKKMDK-----------------------KMKKARKKAKLHS--CKG EEEDPEV----NVEMSLQDEIQRVTNIKTSAKIKSFDLIHSPQGELKAVFLLQNNLVELY SLNPSL---------PTP----QPVRTSRIT----------------------------- --IGGHRSDVRTLSFSSDNIAVLSAA--ADSVKIWN-RSTLQCIRTM------------- ------------------------------TCEYALCSFFVPGDRQVVIGTKTGKLQLYD LASG----NLLETIDAHDGALWSMSL----SPDQRGF-VTGGADKSVKF-WDF----ELV KDENST-Q--------------------------------KRLSV------KQTRTLQLD E-DVLCVSYS----PNQK-----LLAVSLLDC----TVKIFYVD---TLKFFL-SLYGHK LPVICMDISHD-GALIATGSAD-RNVKIWGLDFGDCHKSL---------FAHDDSVMDLQ FVPKSHLFFTAGKDHKIK--QWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKS LRL--------------------WERTREPLILEEEREMEREAEYEESVAKEDQPAVPGE TQG----DSYFTGKKTIETVKAAERIMEAIELYREETAKMKEHKAICKAAGKEVPLP-SN ---------------PILMAYGSISPSAYVLEIFKGIKSSELEESLLVLPFSYVPDILKL FNEFIQLGS--------------------------------------------------- ----------------------------DVELICRCLFFLLRIHFGQITSNQMLVPVIEK LRETTISKVSQVRDVIGFNMAGLDYLKRECEAKSEVMFFADATSHLEEKKRKRKKREKLI LTLT-------------------------------------------------------- ----------------------------- >M_mulatta_ENSMMUP00000011166 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MGLTKQYLRYVASAVF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GVIGSQKGNIVFVTLR------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GEK GRYVAVPACEHVFIWDLRKGEKIL------------------------------------ ------------------------------------------------------------ ---------------ILQG-----LKQEVTCLCPSPDGLHLAVGYED---GSIRIFSLL- SGEGNVTFNG-HKAAITTLKYD--QLGGRLASGSKDTDVIVWDVINESGLYRLKG-HKDA ITQALFLR-E---KNLLVTSGKDTM--VK----WWDLDTQHCFKTMVGHRTEVW--GLVL ------VSEEKRLITGASDSELRVWDIAY--LQE--IEDLEE--PDPKKIKG-SSPGVQD TL--EAEDGTFEM-DEAPEDRILSCRKAGSIMREGR--DRVVNLAVEKTGRILACHGTDS VLELFCILSKEEIKKKMDK-----------------------KMKKARKKAKLHS--CKG EEEDPEV----NVEMSLQDEIQRVTNIKTSAKIKSFDLIHSPQGELKAVFLLQNNLVELY SLNPSL---------PTP----QPVRTSRIT----------------------------- --IGGHRSDVRTLSFSSDNIAVLSAA--ADSIKIWN-RSTLQCIRTM------------- ------------------------------TCEYALCSFFVPGDRQVVIGTKTGKLQLYD LASG----NLLETIDAHDGALWSMSL----SPDQRGF-VTGGADKSVKF-WDF----ELV KDENST-Q--------------------------------KRLSV------KQTRTLQLD E-DVLCVSYS----PNQK-----LLAVSLLDC----TVKIFYVD---TLKFFL-SLYGHK LPVICMDISYD-GALIATGSAD-RNVKIWGLDFGDCHKSL---------FAHDDSVMYLQ FVPKSHLFFTAGKDHKIK--QWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKS LRL--------------------WERTREPLILEEEREMEREAEYEESVAKEDQPAVPGE TQG----DSYFTGKKTIETVKAAERIMEAIELYREETAKMKEHTAICKAAGKEVPLP-TN ---------------PILMAYGSISPSAYVLEIFKGIRSSELEESLLVLPFSYVPDILKL FNEFIQLGS--------------------------------------------------- ----------------------------DVELICRCLFFLLRIHFGQITSNQMLVPVIEK LRETTISKVSQVRDVIGFNMAGLDYLKRECEAKSEVMFFADATSHLEEKKRKRKKREKLI LTLT-------------------------------------------------------- ----------------------------- >M_domestica_ENSMODP00000006461 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MGLTKQYLRYVASAVF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GLIGSQKGNIVFVTLR------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GEK GRYVAVPACEHVFIWDIRKGEKIL------------------------------------ ------------------------------------------------------------ ---------------ILQG-----LKHEVTCLCPSPDGLHLSVGYED---GSIRIFSLL- SGEGNVTFNG-HKAAVTALSYD--QLGGRLVSGSKDTDVIVWDVINESGLYRLKG-HKDA ITQVLFLR-E---KNLLITSGKDTV--VK----WWDLDTQHCFKTMVGHRTEVW--GMVL ------VSEEKRLITGSADSELRAWDITY--IEE--LKDLGE--PNSKKSRG-SSLGTQE NH--ETETGDPGV-DEDPEDRILSCNKAGSIMREGR--DRVVNLAIDRTGRILACHGTDS ILEVFCILSKEEIQKKMDK-----------------------KIKKARKKAKLSS--GEG EQEDSGV----SVVMSLQDEIQRVANIKASAKIKSFDLIHSPHGGLKAVFLLQNNLVEVY TLNPST---------PAP----QPIRTARIT----------------------------- --IGGHRSDVRTLSFSSDNIAILSAA--ADSVKIWN-RSTLQCIRTM------------- ------------------------------ACEYALCSLFVPGDRQVIIGTKTGKLQLYD LASG----NLLETVEAHDGALWSISL----SPDQHGF-VTGGADQSVKF-WDF----ELV KDENCA-Q--------------------------------KRLSV------KQTRILQLD E-EVLSVRYS----PNQK-----LLAVSLLDC----TVKIFYVD---TLKFFL-SLYGHK LPVLCMDISSD-GALIATGSAD-RNVKIWGLDFGDCHRSL---------FAHEDSVMYLQ FVPKSHLFFTAGKDHKIK--QWDADRFEHIQTLEGHHQEVWCLAVSPNGDYIVSSSHDKS LRL--------------------WERTKEPLILEEEQEMQREAEYEDSVAKEDQPVVPGE AQG----DSYFPGKKTVETVKAAERIMEAIELYREETAKMKEHEAICKAAGKEVPLP-VN ---------------PILMAYGNILPSAYVLEVFKGIKSSELEEALLVLPFSYVPDILKL FDEFFQLGS--------------------------------------------------- ----------------------------NIELLCRCLFFLLRIHFGQISSNQMLVPVIEK LKKTTISKVSEVRDIIGFNMAGLEFLKRECEAKSEVEFFSDATNSFEEKKRKRKKREKLI MTLA-------------------------------------------------------- ----------------------------- >P_pygmaeus_ENSPPYP00000001131 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MGLTKQYLRYVASAVF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GVIGSQKGNIVFVTLR------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GEK GRYVAVPACEHVFIWDLRKGEKIL------------------------------------ ------------------------------------------------------------ ---------------ILQG-----LKQEVTCLCPSPDGLHLAVGYED---GSIRIFSLL- SGEGNVTFNG-HKAAITTLKYD--QLGGRLASGSKDTDIIVWDVINESGLYRLKG-HKDA ITQALFLR-E---KNLLVTSGKDTM--VK----WWDLDTQHCFKTMVGHRTEVW--GLVL ------VSEEKRLITGASDSELRVWDIAY--LQE--IEDPEE--PDPKKIKG--SPGIQD TL--EAEDGAFET-DEAPEDRILSCTKAGSIMREGR--DRVVNLAVDKTGRILACHGTDS VLELFCILSKEEIQKKMDK-----------------------KMKKARKKAKLHS--CKG EEEDPEV----NVEMSLQDEIQRVTNIKTSAKIKSFDLIHSPQGELKAVFLLQNNLVELY SLNPSL---------PTP----QPVRTSRIT----------------------------- --IGGHRSDVRTLSFSSDNIAVLSAA--ADSIKIWN-RSTLQCIRTM------------- ------------------------------TCEYALCSFFVPGDRQVVIGTKTGKLQLYD LASG----NLLETIDAHDGALWSMSL----SPDQRGF-VTGGADKSVKF-WDF----ELV KDENST-Q--------------------------------KRLSV------KQTRTLQLD --DVLCVSYS----PNQK-----LLAVSLLDC----TVKIFYVD---TLKFFL-SLYGHK LPVICMDISYD-GALIATGSAD-RNVKIWGLDFGDCHKSL---------FAHDDSVMYLQ FVPKSHLFFTAGKDHKIK--QWDADKFEHIQTLEGHHQEVWCLAVSPSGDYVVSSSHDKS LRL--------------------WERTREPLILEEEREMEREAEYEESVAKEDQPAVPGE TQG----DSYFTGKKTIETVKAAERIMEAIELYREETAKMKEHKAICKAAGKEVPLP-SN ---------------PILMAYGSISPSAYVLEIFKGIKSSELEESLLVLPFSYVPDILKL FNEFIQLGS--------------------------------------------------- ----------------------------DVELICRCLFFLLRIHFGQITSNQMLVPVIEK LRETTISKVSQVRDVIGFNMAGLDYLKRECEAKSEVMFFADATSHLEEKKRKRKKREKLI LTLT-------------------------------------------------------- ----------------------------- >M_mulatta_ENSMMUP00000021364 --KKPHGHVSAHPDILSLEKRCLAMLPDLQPMKKLHQHISAHSDILSLKNQCLATLPDLK TVEKPHGYVSAHPDILSLENRCLATLSDLKTMEKPHGHVSAHPDILSLENRCLATLPSLK STVSASRLFQSLQISHMTQADLYCVNNSNCLLSEPPSWSAQHFSKGLDLSTCPTALKS-L SATGTVQEATLGRWFDSEEKK------GAETQMPSYSLSLGEEEEE-VEDLALKLTSGDS ESHPEPTDQVLQEKKMALLSLLCSTLVSEVNMKDASDPTLAAIFENCRELAPLEPEFILK ASLYARQQLNVRNVANKILAIAAFLPACRPHLRRYFCAIVQLPSDWIQVAELYQSLAEGD ENKLVPLPACLRAAMTDKFAQFDEYQLAKYNPRKHRAKRHPRRPPRSPRMEPPFS--RRP FPRYI-VFLRDEQ-KKFEKAYDTVSEKKNPPRFTLKKLVQRLHIHEPAQHVQALLGYRYP SNLQLFSRSRLPGPWDSSRAGKRMKLSRPETWERELSLRGNKASVWEELIENGKLPFMAM LRNLCNLLRVGISARHHELILQRLQHAKSVIHSRQFPFRFLNAHDSIDALEAQLRNQALP FPSNTTLMRRILTRSDKNRPRRRF---LCHLSCQQLRTVMRVPVMYEKLKREKLRVHKAR QWKYDGEMLNRYRQALETAVNLSVKHSLPLLPGRTILVYLTDANADRLCPKSNPQGPPLN YALLLIGMMITRAEQVDVMLCGGDTLKTAVLKAEEGILKTAIRLQAQVQEF--DEN-GEW SLNTFGKYLLSLAGQRVPADRVILFGQSMDEGMINVAKQLYWQHVNSKCLFVGVLLRRVQ YLSP--DLNPNDVTLSGCTDGILKFIAEHGASHLLEHVGQMDKIFKIPPPPGKTGVQSLR PLEEDTPSPLAPISQQGWRSIRLFISSTFRDMHGERDLLLRSVLPALQARAAPHRISLHG IDLRWGVTEEETRRNRQLEVCLGE----------VENAQLFVGILGSRYGYIPPSYNLPD HPHFHW----------------AQQYPSGRSVTEMEVMQFLNRSQRLQPSAQALIYFRDS SFLSSVPDAWKSDF---------------------------------------------V SESEE-------------------------------AACRISELKSCLSRQKGITCRRYP CEWGGVAAGR---PY--VGGLEEFGQLVLQDVWNTIQKLYLQPGALLEQPVSIPDDDL-- --------------VQATFQQLQKPPSTARPRLLQDTVQQLMLH------HGRLSLVTGQ SGQGKTAFLASLVSALQAPDGAKVAPLVFFHFSGARPDQGLALTLLRRLCTYLRGQLKEP -GALPN-TYRSLVWELQQRLLPKSAESLHPGQTLVLIIDGADRL--VDQNGQLISDWIPK KLPRCVH----LVLSVSRDAGLGETLEQSQGAHVVALGPLEASARARLVREELALYGKRL EESPFNN-------------QVGKLWFLIMSPSPLPLALPVSMSRSVLLTFQVSERLRTL PAT-----VPLLLQHILSTLEQEHGPDVLPQALTALEVTRSGLTV--DQLHGVLSVWRTL P-KGTKSWEEAVAAGNSGDPYPMGPFAYLVQSLRSLLGE-----G-PLERPGARLCLPDG PLRTAAKRRYGKRPGQEDTAHILIAAQLWKTCDADASGTFRSCPPEALVDLPYHLLQSGN RGLLSKF-LTNIHVVAAHLELGLVSRLLETHALYASSVPKEEQKLPEADVTVFRTFLRQQ ASILSQYP-QLLPQQ-----------AANQPLDSPLCQQAPLL---SQRWHLQHTLRWLN KPQTMKNQQS---SSLSLA-----VSSSPTAVAFSTNGQRAAVGTAN---GTVYLLDLR- TWQEEKSLVS-GCDGISACLFL---SDDTLFLTAFDGLLELWDLQHGCRVLQTKA-HQYQ ITGCCLSP-D---RRLLATVCLGGC--LK----LWDTVRGQLAFQHT-YPKPLN--CVAF ------HPEGQVIATGSWAGSISFFQVDG--LKV-------------------------- ----------------------------TKDLGAPG--ASVRTLAFNVPGGVVAVGRLDS MVELWAWREGARLAAFPAHHG---------------------FVAAALFLHAGCQLLTAG EDGKV--------HVWSGSLGRPRGDL-GSLPLSPALSVALSPDGDRVAVGYRADGIRIY KISSGS---------QGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECSLQSL WLLSRFQKPVLGLATSQE--LLASAS-EDFTVRLWP-RQLLTLPHKA------------- -------------------EDFPGGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWD VRTPKAPILIHSFPACHRDWVTGCAW----TKD--NLLISCSSDGSVGL-WDP----ESG QRLGQFLGHQSAVSAVAAVEE----HVVSVGRDGTL----KVWDH-Q--GVELTSIPAHS G-PISHCAAAMEPRAAGQPGSELLVVTIGLDG----ATRLWHPL---LVSQTH-TFLGHS GPVRAAAVSET-SGLLLTASED-GSVRLWQVPKEADDTCI---------PRSSAAITAMA WAPDGSMAVSGNQAGELI--LWQEAK--AVATAQAPGH-IGALIWSSARTFFVLSADEKI SEW--------------------QVKLRKGSAPGNFSLHLNRIL--QE------------ -------DLGVLTSLGWAPDGHFLILAKADLKLLCMKPGDAPSEIWSSYTENPMIL-STH ---------------KEYGVFVLQPKDPGVLSFLRQKESGEFEERLNFDINLENPSRTLI SITQAKPES---------ESSFLCASSDGMLWNLAKCSPEGEWTTGNIWQKKANIPETQT PGADPSTCRESD------ASMDSEP-TSQLKTRQRRKIHSGSVTALHVLPELLVTASKDR DVKLWERPSMQLLGLFRCEGSVSCLEPWLGANSTLQLAVGDVQGNVYFLNWE-------- ------------------------------------------------------------ ----------------------------- >B_taurus_ENSBTAP00000026561 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MGLTKQYLRYVASAVF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GLIGSQKGNIVFVTLR------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GEK GRYVAVPACEHVFIWDLRKGEKIL------------------------------------ ------------------------------------------------------------ ---------------ILQG-----LKHEVTCLCPSPDGLHLAVGYED---GSIRIFSLL- SGEGNVTFNG-HKAAITSLKYD--QLGGRLASGSKDTDIIVWDVINESGLYRLKG-HKDA ITQALFLR-E---KNLLVTSGKDTM--VK----WWDLDTQHCFKTMVGHRTEVW--GLVL ------VSEEKRLITGASDSELRAWDISY--LQEKQIEDPEE--PEPKKIKE-SSPGIQD SH--EAEDGTLEM-DETPEDRILTCRKAGSIMREGR--DRVVNLAVDKTGRILACHGTDS VLEVFCILSKEEIQKKMDK-----------------------KMKKAKKKAKLNS--CNE EEEDLEV----NVKMTLQDEIQRVANIKTSAKIKSFDLIHTPQGELKAVFLLQNNLVELY SLNAST---------PGP----QPVRTNRIT----------------------------- --IGGHRSDVRTLSFSSDNIAILSAA--ADSIKIWN-RSTLQCIRTM------------- ------------------------------ACEYALCSFFVPGDRQVVIGTKTGKLQLYD LASG----NLLETIDAHDGALWSLSL----SPDQRGF-VTGGADKSVKF-WDF----ELV KDENST-Q--------------------------------KRLSV------KQTRTLQLD E-EVLCVSYS----PNQK-----LLAVSLLDC----TVKIFYVD---TLKFFL-SLYGHK LPVICMDISYD-GALIATGSAD-RNVKIWGLDFGDCHKSL---------FAHDDSVMYLR FVPKSHLFFTAGKDRKIK--QWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKS LRL--------------------WERTREPLILEEEKEMQREAEYEESVAKEDQPAVPGE TQG----DNYFTGKKTIETVKAAERIMEAIELYREETAKLREHKAICKAAGKEVPLP-IN ---------------PILMAYGNISPSAYVLEIFKGIKSSELEESLLVLPFSYVPDILRL FNEFIQQGS--------------------------------------------------- ----------------------------DIELLCRCLFFLLRIHFGQITSNQMLVPVIEK LKETTISKVSQVRDVIGFNMAGLDYLKRECEAKSEVMFFADATSHLEEKKRKRKKREKLI LTVT-------------------------------------------------------- ----------------------------- >R_norvegicus_ENSRNOP00000026726 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MGLTKQYLRYVASAVF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GLIGSQKGNIVFVTLR------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GEK GRYVAVPACEHVFIWDLRKGEKIL------------------------------------ ------------------------------------------------------------ ---------------ILQG-----LKQEVTCLCPSPDGLHLAVGYED---GAIRVFSLL- SGEGNITFNG-HRAAVTSLKYD--QLGGRLASGSKDTDVIIWDVINESGLYRLKG-HKDA VTQALFLR-E---RNLLVTSGKDTM--VK----WWDLDNQHCFKTMVGHRTEVW--GLVL ------VSEETRLITGAADSELRAWDIAY--LQE--IDDPEE--PEPKKIKE--CPGIQD TP--EAEDRTLEADDEKSEDRILSCRKAGSLMREGR--DRVVNLAVDKTGRILACHGTDS VLEVFCILSKAEVQKKMDK-----------------------KLKKARKKARLNS--AN- EEEDPET----SVSMTLQDEILRVTKIKTSAKIKSFDLIHSPQGELKAVFLLQNNLVELY SLSTSL---------PNP----QPVRTSRIT----------------------------- --IGGHRSDVRTLSFSSDNIAVLSAA--AESVKIWN-RSTLQCIRTM------------- ------------------------------PCEYALCSFFVPGDRQVVIGTKTGNMQLYD LASG----NLLETIAAHDGALWSMSL----SPDQRGF-VTGGADKAVKF-WDF----ELV TDKNST-Q--------------------------------KRLSV------KQTRILQLD E-DVLYVCYS----PDQR-----LLAVSLLDC----TVKIFYVD---TLKFFL-SLYGHK LPVICMDISHD-GALIATGSAD-RNVKIWGLDFGDCHRSL---------FAHDDSVMHLR FVPKSHLFFTAGKDHKIK--QWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSASHDKS LRL--------------------WERTREPLILEEERELQREAEYEESVAKEEQPAVPGE TQG----DNYFTGKKTIETVKAAERIMEAIELYREETAKMKEHRAICRAAGKEVPLP-VN ---------------PILMAHGNISPSAYVLETFKGIRSSELEEALLVLPFSYVPDILTL FNGFIQTGS--------------------------------------------------- ----------------------------DVELLCRCLFFLLRIHFGQITSNQMLVPVIEK LKETTISKVRQVQDVIGFNMAGLNYLKRECEAKSEVMFFAEATSHLEEKKRKRKNRRKMI LTLT-------------------------------------------------------- ----------------------------- >A_gambiae_AGAP009615-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SPLICGSRRYEVKQQYKAF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------YTGGTIVW--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPD AQQFLCLNNGTISIVSV-DNLHEPVAL--------------------------------- ------------------------------------------------------------ ---------------GEQETDGEIAEDVIYTFAVSNTGNSIVSGHRS---GLLKLWDGE- KHTVQKMWKTVHQGPISRLVFS--PTDSVIASGGSDSTIRLWDPTEQVCLGTLRG-AEGL INVIVFHP-DAD-SKIVVAVGDDTK--IR----AWDYESRKQVKTFEGHFSRVT--GVSF ------SEDRTHLVSAGRDKILILWNFES--QQA-------------------------- -----------------VKTIPVYETLESVVVLP---------------------AGLRG LIKVWEMTGAKIIFKQSNSLVA-----------KAAEEGGL-AITHLFYSEPHGRMAVVS ADHNI--------LVHDCESFDYVHQL-SGFSDEILDLILFGKRDQHIAMATNSSDFKVY DVSTMN-----------------------------------------------------C RLVKGHTDIVLSLCANDR--YLLSSS-KDNSIRLWS------------------------ ---------------------------FTEEPFTISC----------------------- ----------VAIGLKHTNTVGCVTL----SRQGGNFCASVSQDRCLKT-WKI----PKK FT-TEEDG--------------------------------ELPRL-----QCSLTALAHE K-DINCVTIS----PNDR-----LIATASQDK----TAKLWDAS---DLSVVG-VFRGHT RGIWAVRFSPV-DQILLTNAAD-CTIKLWSLEDMTCLKTL---------EGHDSSVLRVE FLTNGMQLLSAGADGLVK--LWSIKTSDCVQTLDKHDNRVWALCVTRDESMFYSGGSDSQ LIQ--------------------WQDVTESKRQQELDQRKDTLLQEQEL----------- -------SNLLSERKLLKALRLSLNLDRPLSTLKIVNEVIRTKE---------------- ---------------------------------------QGLEDTVRKLSNDHKERLLRH AIEWNTNSK--------------------------------------------------- -----------------------------------------NCRPAQLALNVLLQETLAG RF-QVSELNKHLEASLPYTERHFKRLTEYVKDLKFVEYSLRCMQPHAARMD--------- ------------------------------------------------------------ ----------------------------- >B_taurus_ENSBTAP00000027147 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------GDAISASPRCGMAPGSPSRGGTGDMAEVAAGVGRFKSNYAVERKIEPF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------YKGGKVQL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------DQT GQHLFCVCGTRVNILDVASGAVLRS----------------------------------- ------------------------------------------------------------ ---------------LEQE-----DQEDITAFDLSPDDKVLVTASRA---LLLAQWAWQ- EGSVTRLWKAIHTAPVATMAFD--PTSTLLATGGCDGAVRVWDVVRCYGTHHFRG-SPGV VHLVAFHP-DPA-RLLLFSSAADTS--IR----VWSLQERSCLAVLTAHYSAVT--SLTF ------SADGHTMLSSGRDKICVIWDLRS--LQA-------------------------- -----------------TRTVPVFESVEAAVLLPEE---PAPELGVKSAGLHFLTAGDQG ALRVWEAASGRCVHAQ-----------------QRLRGPGR-ELTHCTLAHAAGLLLSVT ADHNL--------LLYDAHSLRLRKQF-AGYSEEVLDVRFLGPEDSHVVVASNSPCLKVF DLQTSA-----------------------------------------------------C QILHGHTDIVLALDVFRKGRLFASCA-KDQSIRVWR------------------------ ---------------------------MN-KSGEVAC----------------------- ----------VAQGSGHTHSVGTICC----SRLKETFLVTGSQDCTVKL-WPL----PEA LLSKGTGHE--G----------------------------GPVFL-----QAQATQRCHD K-DINSVAVA----PNDK-----LLATGSQDR----TAKLWALP---RCQLLG-TFSGHR RGLWCVQFSPM-DQVLATASAD-GTIKLWALQDFSCLKTF---------EGHDASVLKVA FVSRGTQLLSSGSDGLLK--LWTIKNNECVRTLDAHEDKVWGLHCSRLDDRALTGASDSR VVL--------------------WKDVTEAEQAEEQAKREEQVVKQQEL----------- -------DNLLHEKRYLRALGLAISLDRPHTVLTVIQAIRRDPESC-------------- ---------------------------------------EKLETTVLQLRRDQKEALLRF CVTWNTNSR--------------------------------------------------- -----------------------------------------HCHEAQAVLGVLLRHEAPD ELLTYDGVRASLEGLLPYTERHFQRLSRMLQAATFLDFLWHNMKLPALPTAPAAL----- ------------------------------------------------------------ ----------------------------- >X_tropicalis_ENSXETP00000035244 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------HILQ---MELVSAVCCSLVRGPKFSDSCDETRVKLLALCEELSNLDPEFILK VALYTRQELNIRSTANFMLAVSAFLPACRPHLRRYFCASVQLPADWMEIPRLYQSLA-GQ GEKLAPLPSCLRRVLTVKFQKFTEYQLAKYNTRRQRGKHSIRKPKLSRFLNFLFF---HI FPLVVDKGLKLLQ-KKFSTP--PTPKMKTKDRFSMKSLIQRLHISKPTHHVMGILGCKYP KDLYSFSKSGLEGPWQSDLSGQKMKLKQPQTWDRELSLKGNTGLVWEKLLDSDQVPFMAL LRNLRNMIRAGISRQHHNQVTSRLSSERAVIKSRMFPFRFLSAYKVIQDLENQCHVSGKP FPVNVRLIKNIVTSEAASI----PELKRYTWSRRQLRGCLAVPAIRQLLKRKKEALRKLR ACKMDQAILQKYKKALESAVKISARYNITPLPGRTVILFYVSESMDKPCHGAK----DLK VGLLLSGMVRDTSESAQVVLFNDQTYILAEFNS-SSLLHNVSHLKKQAEDLKSQGRYSSR NKNVAKKYLMELLANRTKVDTLLLFRLSPPSAEFKSVLKQYRREVNTDCLCVTVVPENLQ REES--FDQCNDVVLHGFTEQVLRYVSERGTVRLLDHVAKVNERFQVPEDPDSVK-RSHD FGHEVIPSPIT----QRWRSIRIFISSTFRDMHSERNLIIGQVIPELRSRAACHYLSVEE VDLRWGITEEETRKDRQLHLCLSE----------VCRSQIFIGILGERYGHVPKTYSLPL LSEYEW----------------EGTLASNEDEEELAQEGFQERQTSLSCARRYLLYL--- -LFSSIPSKWVSDF---------------------------------------------G AESAE-------------------------------AEMKMSSLKSRLTEHSSAATYRYS CQWGGELQGK---PH--LTRLQNFGIRVLEDIWQAIERDYIKEGTLASNE---DEEEL-- --------------AQEGFQERQTSLSCARSKLVLSTCSQIQERTHASPTNGRLFLVCGD RSQGKTIFMADLVKQLR----SSASTTVIYHFMGATPGAHEVEKMLTRICKQLSQGLNRE -CCNFT-SYRALLSEFHD-LLRLTSHSLRRNNTLTLLIDGADLL--CGRAGETTSEWIPE HLPQRIN----LVLSVTEGSSLGYSLARQKDTVSISLTSLQPSDRAELVRHWLAVYGKKL EESAFNN-------------QMRLLLIKKGTKHPLYLTMACEELRATAVFERLSDDIEKL PAT-----LPALIQRRLESLEQEHGVTTVSIALAVICLSRKGLPE--RDLLRILSSLQAL NCVFTAKWNAMLAAFAGAQNLPMATFALLLRGVRSVLGL-----WLPALTSDHRLHLPSC LLRDAVEKRYLMKRDVTKAAHLLMAAHFWTVCSPEDPDSVPVINAECLSELSHHLLCSEQ LHTLGWL-LTHLPFLRVHAALGLLPHLCQVYSMYDCTIHELDRQVSKLPVDVFREFIHNS LPVLSKNP-SLFYQQ-----------ALNEPDCSPVCFQARVIIDNRKECTSHLTMLWNN KPAYMSICRSLFPDSKSLE-----IPSLLGCVSLSPSGRMAAVGASS---GALHLINTD- SGEEVRILHS-GCDGVSACNFI---SDDLLCVGSYDGILEIWKISDGCRMHRAEA-HRRQ ITGCCVSP-D---QRQLITCSLDYQ--LK----LWETSRGSLLGSIS-FPYPLA--CTTF ------HPRGHVVAVGSWDGKITVLRLEN--WEK-------------------------- ----------------------------TAVL-CGS--SSVRTVSFSQDGKWLISGSLDG WVSLWAWEAQVQLSHFKAHSG---------------------STLTCSFLQQGKYLLTGG EDSKV--------QVWSGGLGRLLGRVDGEIKNSSAISLAVSPSRQLLAVGYHTGTVSVY SVDLGD---------LVAQTSIEDVTILCVAWLSEEVLVTGTSDSLVRVWKISSGQFTCQ LMLKEHQRFVQALAVSSK--LLASAS-GDVSVCLW---SLNSLLNSV------------- -------------------SPPSPASVLQGHSAAVTCCSFSRNGKLLATGSQDRSVLCWD VSLI-PPSVVHALPSCHRDWVTACSW----TDA--DMLVSCSGDGSVCL-WDI----QRE ERLLDFAGHQSAVSSAICMGE----RVITTSRDGCL----KVWNL-A--GLEVANISAHQ E-QINQSAAFWMP-VDRQDDANLVVYVACSDG----SVLKWSPL---QMDQIQ-TLYGHG GPVISSSSSSSNCKVIATASLD-GSVRLWEEPSRDGHVME---------TRHVGRVSAIA YSPDSELVASGGENGDVI--LWSQQR--VLLSLQVNKMCISHLLFTSQRTFCVISNDLKV SRW--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >A_aegypti_AAEL004364-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MGLTKQYLAFKPVANF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------NIIASGRANVAFVSVG------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GVD GRFVAVAGAEQVLVWNTRLGEKVL------------------------------------ ------------------------------------------------------------ ---------------EFAR-----DKQEVTFLRPSPDRKHLAVGYTD---GVIEMFSFE- SKQSVCTFSA-HRSAVSAMNFD--LIGLKLVSGGLDNDLVVSDVVAQSGKCRLVG-HNGA ITEACFMERY---HDVVVSSSKDTQ--IK----FWNIETQSCFKTIVDHRTEVW--GIAL ------MRNDDFLVAGSGDTQLAVYKIAE--NTS-------------------------- NAVEEPTGDLGDLLLESEATSPFRCTQIGNIQRSGF--GRTINLVVENNGQILGCHGTDK KIELFYFYSVDEALVRLTK-----------------------RLKKLDAKSKADD----T NANANLA----ERQLSLVDEIKRLPAISVPEKVKSFDLLLGSNDELRICVTFVKNFIQVF TLNVAE---------KHA----EASAIHTIR----------------------------- --QQGHPSEVRSVAFSSDSLAIASGS--GESLKLWS-RASQSSLRTV------------- ------------------------------DTGYVVSTCFVPGDRHVLVGLKTGQLLIVD IVTG----EIIERIAAHEKELWSIVL----TPDMRGC-VTGGGDTTVKF-WSF----ELI ADPTKDAKSEV-----------------------------KVLSL------LHKNVLKLE E-TVLCVRIS----RNSK-----YIAVALLDS----TVKIFFLD---TLKFYL-SLYGHK LPVLCMDISYD-STIIVTGSAD-RSIKIWGMDFGDCHRSL---------IAHDNSVMGLQ FIPKTHLFFSCGKDGKLK--QWDADSFEKIITFQGHVGEAHSLAVSPNGKFVVTCGSDRT LRL--------------------YERTEEPLVLQDVQEEEREELENNTLATGEESTVPGL P------GLKLPSKKTIGAEKAAENILECLEVSK--KFEEEDTKNIIP------------ ---------------PLMYAYEATNTDDFLLAVLTRIRASDLEEALLLLPFSAVCELLER IPKLTETRQ--------------------------------------------------- ---------------------------DQTETICKVVLFLFRIHQKPIVNNQMLLPVIQE IIGKLQGAIVGLRDMIGVNFHGMQMLQREVEANQGVELFRDATKTRRQKDMRRKRKEAAA KRAFVQIST--------------------------------------------------- ----------------------------- >O_anatinus_ENSOANP00000004860 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MGLTRQYLRYVAGAVF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GLVGSQKGNAVFVTLR------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GEK GRYVAVPACEHVFIWDPRKGEKIL------------------------------------ ------------------------------------------------------------ ---------------ILQG-----LKQEVSRLCPSPDGLHLAVGYED---GTVRIFSLL- SGENTVTFNG-HKAAVTALKYD--HLGGRLVSGSKDTDVIVWDVINESGLFRLKG-HKDA VTEALFLR-E---RDLLVTSGKDTM--VK----WWDLDTQHCFKTMVGHRTEVW--GLAL ------VSDDRRLITGAADSELRAWDITW--AQGAQPRDPAE--PDAKRARG-PPPATPG EP--QEEE------DEAPEERILSCTKAGSIMREGR--DRVVGLAADRTGTVLACHGSDS VLELFRVLSEEEIQKKIDK-----------------------RMKLARKKAKRVE--RAG RRRPPQRSFPAVSPVTLQDQIRRMVNVKASAKIKSFDLIRGPRGEVKAALLLQNNQVELV SVTPAQ---------PVP----QVVRGAQIS----------------------------- --TGGHRTDVRTLSFSSDNIAVLSAS--AESVKIWNSRSTLQCIRTL------------- ------------------------------ACEYALCSLFVPGDRQVIVGTKKGKLQLYD LASA----SLLETVEAHAGAVWSISL----SPDQRGF-VTGGADKTVRF-WDF----HLV KDADGP-Q--------------------------------KRLSV------GEARTLQLD E-EVLCVRYG----PDRK-----LLAVSLLDC----TVKLFYVD---TLKFFL-SLYGHK LPVLCMDISSD-GQLLATGSAD-RNVKIWGLDFGDCHRSL---------FAHADSVMFLQ FVPKTHLFFTAGKDNKIK--QWDADKFEHVQTLEGHHHEVWCLAVSPSGDHLVSASHDKS LRL--------------------WERTREPLVLEEEREMQREAEYEDSVAKEDQPVVPGE AQG----EASLAGKKTIQTVKAAECIMEAVELFREETAKRAEHAAVCKAAGKEVPLP-PN ---------------PLLQALGNISPSDYVLEVLKKVKSSELEESLLVLPFSYVPDLLLL FNQFIQLGQ--------------------------------------------------- ----------------------------DVELLCRCLLFLLRVHFGQITNNQMLVPAIEK LKETTVSKVGHVRDNIGFNIAGLEFLKREIEAREDVTFFADATDRVAERRRKRKKREKLV LAMT-------------------------------------------------------- ----------------------------- >E_caballus_ENSECAP00000005446 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MGLTKQYLRYVASAVF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GLIGSQKGNIVFVTLR------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GEK GRYVAVPACEHVFIWDLRKGEKIL------------------------------------ ------------------------------------------------------------ ---------------ILQG-----LKQEVTCLCPSPDGLHLAVGYED---GSIRIFSLL- SGEGNVTFSG-HKAAITSLKYD--QLGGRLASGSKDTDVIVWDVINESGLYRLKG-HKDA ITQALFLR-G---KNLLVTSGKDTM--VK----WWDLDTQHCFKTMVGHRTEVW--GLVL ------VSEEKRLVTGTSDSELRAWDIAY--LEE--IEDPEE--PEPKKIKG-PSSGIQD TH--EAEDGALET-SEAPEDRILTCRKAGSIMREGR--DRVVNLAVDRTGRILACHGTDS VLEVFCILSGEEIQKKKDK-----------------------KMKKARKKAKLSS--CKG EEEDLEV----SVEMTLQDEIQRVTNIKTSAKIKSFDLIHSSQGELKAVFLLQNNLVELY SLSPSA---------LTT----QPVRASRIA----------------------------- --IGGHRSDVRTLSFSSDNIAVLSAS--ADSIKIWN-RSTLQCIRTM------------- ------------------------------TCEYALCSFFVPGDRQVVIGTKTGKLQLYD LASG----NLLETIDAHDGALWSLSL----SPDQRGF-VTGGADKSVRF-WDF----ELV KDENST-Q--------------------------------KRLSV------KQTRTLQLD E-DVLCVSYS----PNQK-----LLAVSLLDC----TVKIFYVD---TLKFFL-SLYGHK LPVICMDISYD-GALIATGSAD-RNVKIWGLDFGDCHKSL---------FAHDDSVMYLQ FVPKSHLFFTAGKDRKIK--QWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKS LRL--------------------WERTREPLILEEEREMQREAEYEESVAKEDQPAVPGE TQG----DNYFTGKKTIETVKAAERIMEAVELYREETAKMKEHKAICKAAGKEVPLP-IN ---------------PILMAYGSISPSAYVLEIFKGIKSSELEESLLVLPFSYVPDLLTL FNELIQLGS--------------------------------------------------- ----------------------------DVELLCRCLFFLLRIHFGQITSNQMLVPVIEK LKETTISKVRQVRDVIGFNMAGLDYLKRECEAKSEVMFFADATSHLEEKKRKRKKREKLI LTLT-------------------------------------------------------- ----------------------------- >S_cerevisiae_YLR222C ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MDLKTSY-KGISLNPI--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------YAGSSAVATV------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SEN GKILATPVLDEINIIDLTPGSRKILHK--------------------------------- ------------------------------------------------------------ ---------------ISNE-----DEQEITALKLTPDGQYLTYVSQA---QLLKIFHLK- TGKVVRSMKI--SSPSYILDAD--STSTLLAVGGTDGSIIVVDIENGYITHSFKG-HGGT ISSLKFYG-QLN-SKIWLLASGDTNGMVK----VWDLVKRKCLHTLQEHTSAVR--GLDI IEVPDNDEPSLNLLSGGRDDIINLWDFNM--KKK-------------------------- --------------CKLLKTLPVNQQVESCGFLKDG-----------DGKRIIYTAGGDA IFQLIDSESGSVLKRTNKPIEEL-------------------FIIGVLPILSNSQMFLVL SDQTLQLINVEEDLKNDEDTIQVTSSI-AGNHGIIADMRYVGPELNKLALATNSPSLRII PVPDLS--------------------------------------------GPEASLPLDV EIYEGHEDLLNSLDATEDGLWIATAS-KDNTAIVWR------------------------ ---------------------------YNENSCKFDI----------------------- ----------YAKYIGHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKK-WII----PKP TASMDV----------------------------------QIIKV------SEYTRHAHE K-DINALSVS----PNDS-----IFATASYDK----TCKIWNLE---NGELEA-TLANHK RGLWDVSFCQY-DKLLATSSGD-KTVKIWSLDTFSVMKTL---------EGHTNAVQRCS FINKQKQLISCGADGLIK--IWDCSSGECLKTLDGHNNRLWALSTMNDGDMIVSADADGV FQF--------------------WKDCTEQEIEEEQEKAKLQVEQEQSL----------- -------QNYMSKGDWTNAFLLAMTLDHPMRLFNVLKRALGESRSRQDTEEGKIEVIF-- --------------------------------------NEELDQAISILNDEQLILLMKR CRDWNTNAK--------------------------------------------------- -----------------------------------------THTIAQRTIRCILMHHNIA KLSEIPGMVKIVDAIIPYTQRHFTRVDNLVEQSYILDYALVEMDKLF------------- ------------------------------------------------------------ ----------------------------- >E_caballus_ENSECAP00000009299 -------------------------LPDLKTMEKPHGHVSAHPNILSLENRCLSTLPDLK TVEKPHGHVSSHPNVLSLENRCLATLPDLKTVEKPHGHVSAHPNVLSLENRCLATLPILK STVSASALLQRLQTFHPVQADLCSLNTSNHLLSEPPTWRAQYLSEGLGLLTFPGALQS-I SATETVQEAAVGHWSSSEEKR-PGAEEWAEAPMPFYSLSLG-EEEE-VEELALKLTSGES ESCPEPTDRALQEKKMTLMSLLCSTRASNVNMKDAADPTAASLFEICSELAPLEPEFILK ASLYTRQQLNVRDVANRVLAIAAFLPVCRPYLRRYFCAIVQLPSDWIQVAEFYQSLAEGE ENKLVPLPSCLRAAMTDKFAQFDEYQLAKYNPRKHRAKSRPRRRPHPPKTEHPFSERQRY LPKCL-APLMDEQ-KKFEASYNVVPEKKKQPRFTLKKLVQRLHIKEPAQHVQALLGYRYP SNLQAFSRSRLPGPWDSSRAGKRMKLSQPETWERELSLRGNKASVWEELIDNGKLPFMAM LRNLCNLLRVGISPRHHELVLQRLQHAKSVIHSRQFPFRFLNAHDSINDLEAQLKSKALP FPSNTKLMRQIMIRNSKNIKRHAYQKKLCNPSRRELRAAMMVPLMYEQLKREKLKIHKSR QCKYDSETLARYRQALETAVNLSVKHSLPPLPGRTLLVYMTDAEADKLCPKNNPQGPPLN YVLLLIGMMIARAEHADLLLCGSGTLKTAVLKAEEGILKTAIELHAQVQEL--DGNYYEF SRDTFGKYLLSLAAQRVPVDRVILFGHIMNGSLINEAKQLFWQHVNSKCLFVGVCLRRIC YTFS--DSNPNDVTLLGCTDGILKFIAERGASRLLEHVGQMDKIFKIPPPPGKTGAPSLR PLEENTPSPLASISQSRWRKIRLFISSTFRDMHGERDLLLRSVLPALQARAAPHRISLHA IDLRWGVTEEETRRNRQLEVCLGE----------VENSELFVGILGSRYGYIPPNYNLPD HPHFRW----------------AQQYPSGRSVTEMEVMQFLDRSLRLQPSAQALIYFRDS SFLRSVPDAWKSDF---------------------------------------------T SESEE-------------------------------AAHRISELKSSLNRQKGITCRRYA CEWGGVAAGR---PY--VGGLEEFGQLVLQDVWNMIQKLYLQPEAQLEQPVSVPDDDL-- --------------VQATFQQLRKPLSSARPRLLQDMVQQLMLH------RGRLSLVTGQ SGQGKTAFLASLVSALQAPDGVKVAPLVFFHFSGARPDQGLALTLLRRLCAYLHSQLQEP -SALPS-TYRGLVWHLQQRLLPKSAQSLQSGQTLVLIVDGADRL--VDQHGELISDWIPK TLPRWVH----LVLSMSTDAGLGESLEQSQGAHVVALGPLEPSARARLVREELALYGKRL EESPFNN-------------QMRLLLVKRGSALPLYLRLVTDHLRLFTLYEQVSERLRTL PAT-----VPLLLQHILGTLEQEHGPSVLPQALATLEVTRSGLTV--DQLHGVLSAWRIL P-MGTKTWEEAVAAGDSGDPYPMGPFAFLVQSLRSLLGE-----G-PLERPGARLCLRDG PLRTAAKSRYGRRPGLEKTAHILIAAQLWKACDPDASGTFRSCPPEALGDLPYHLLQSEN YGLLTKF-LTNLHVMAAHLELGLISRLLEAHALYASSIPEEGQKLPEADVAVFHTFLRQQ APVLSQYP-LLLPQQ-----------AANQPLDSPLCLQAPQL---SQRWHLQRMLRWLN KPQTTRGQQT---TSLSLA-----VSSSPTAVAFSPSGQRAAVGTAS---GTVYLLDLR- TWQEEKSVVS-GCDGVSSCSFL---SDNALFLTAFDGLLELWDLQHGCRVLQTNA-HQYQ ITSCCLSP-D---NRLLATVCLGGC--LK----LWDTVRGQLAFQHT-CPKPLN--CVAF ------HPEGQVVAIGSWSGSFSFFQVDG--LKV-------------------------- ----------------------------TKELGAPG--ASVRTLAFNVPGQVVAVGRLDR MVELWAWKEGARLAAFPAHHG---------------------FVAAALFLRAGCQLLTAG EDGKV--------QVWSGSLGRPRGCL-GSLSLSPALSVALSPDGDRVAVGYRADGIRIY KISSGS---------QGAQCQALDVAVSALAWLGPKVLVSGAEDGSLQGWALKESSLQSL WLLSRYQRPMLGLATSQE--LLASAS-EDFTVRLWP-RQLLTLPQKA------------- -------------------EDFPCATELRGHEGPVSCCSFSTDGGSLATGGRDRNLLCWD VRTPKAPVLICSFSACHRDWVTGCAW----TKD--NLLVSCSSDGSVGL-WDP----ESG QQLGQFLGHQSAVSAVVAVEE----HVVSVGRDGTL----KVWDH-Q--GVELTSIPAHS G-PISQCAAALEPRAAGQPGSELLVVTAGLDG----TTQLWHPL---LVFQTH-TLLGHS GPVSAAAVSET-SGLLLTTSED-GSVRLWQVPKEADDTYI---------PRSPTAITAVA WAPDGSLAVSGNQAGELT--LWQEAK--AVATAQAPGR-ISSLVWYSAHTLIVLSADEKV SEW--------------------QVEWQKDSTPGNFSLHLKQVL--QE------------ -------DLGFLTGMALAPDGHSLILAKADLHLLRMKPGDAPSEIWTSFGEHPIML-STH ---------------QDYGVFILQPTASGALSVLRQKESGEFEETLDFCVNLENPGGTLT LVTQAKPES---------ESSFLCASSDGMLWNLAKCTLEGQWTTDNIWQKEAKMPETQT PGTDPSID----------TDVDSWPRTTDLKTQQRRKIHSGSVTALHVLPELLVTASKDR DVKLWERPSMQLLGLFRCEGAVSCLEPWLGPDSTLQLAVGDMQGNVYFLSWE-------- ------------------------------------------------------------ ----------------------------- >X_tropicalis_ENSXETP00000021860 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MGLTKQYLRYAASAVF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GLIANQKANVAFITLR------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GER GRYVAVGACEHVFIWDTRRGEKVL------------------------------------ ------------------------------------------------------------ ---------------ILQG-----QKQEVTRLCPSPDGLSLAVGYED---GSIRIFSLL- SGESGITFNG-HKAAVTALNYD--HLGGRLVSGSKDTDVIVWDVINESGLYRLRG-HKDA ITQALFLR-E---KNLLISSGKDTL--VK----WWDLDTQHCFQTMVGHRTEVW--GLTL ------LSEESRVLTGSADSELRAWNISY--MKE--TEDTDG--PQSKKSKG---PLGEA Q---EEEE---DV-EESTEGRILSCQRFGSIMREGR--DRVVSLGTDRTRRFLACHGADS VLEVFCALNEEEIAKKMEK-----------------------KLKRAKKKAKQKS---ED AEEEEEL----KVERCLQDEIQRLGNIKASSKIKSFDLFAGAKGELKAVLLLQNNSLECY SL-PAE---------PTPAGKAECTRTSRLT----------------------------- --LGGHRSDVRTLAFSSDNIAVLSAS--AETVKIWN-RSTLQCIRTM------------- ------------------------------PCEYALCSLFVPGDRHVIIGTKSGNLQLFD LASG----NLLETVNAHDGAVWSICP----SPDLRGF-ASGGADKTVRF-WDF----ELV NEETEE-QSS------------------------------RRLSV------KQTRVLQLD E-DVLCVRYS----PNGR-----ILAVSLLDC----TVKVFYTD---TLKFFL-SLYGHK LPVLCMDICHD-NGLFVPGFAD-RNVKIWGLDLGDCHRSL---------FAHEDSVMFLQ FVPKTHLFFSAGKDRKVK--QWDADHFQQVQTLEGHHGEVWCLAVSPNGDHVVSSSHDKS LRL--------------------WERTREPLILEEEKEMQREAEYEESVAKGQQPVVAGE REG----EVGLAGKKTIETVKATERIMEAIELHREETAKLEEHRALCKAAGKELPHR-TH ---------------PILQAYGNISPSDYVLDVFKKVKSSELEESLLVLPFSYVSDALAL FRDYIRQGR--------------------------------------------------- ----------------------------DVELICRCLFFLLRIHFGQITSNQMLLGVIED LKNCTISRVAEVRDMMGVNMAALQFLKREVGAREEVQFFADATERFEEKKRKRKKNEKLL LAVV-------------------------------------------------------- ----------------------------- >A_gambiae_AGAP004827-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------MATAIEEA VFNALRGHHNEHTKLPSPRIIKIYIASLKDDFKEERRLLLEIIGPDLQALYDDRQLEIEI VDIHFGTGSDGLTIVDLDPYVLDDHLEEIETCHCVSKSVFLIVLLGSRLGNFLLPTKLDS SIFTAI--SKLSTDDEVQCLRKWYSTTCPKTNIHQTEDTQTLDRAEWVTEAQQLRELLER KIDEVLRAAETKETSAGDG--------------LDGEQFCDNLKRLKTRAIAREIEKGLA CSSGRILTLFRHWKNQPENDSTELEEDGHLGSNTGTEVKQVETNLIEALPASNHQTLTVD --WAENGIDPELECH--DLYLTSFKNKIFEMMKASIDQDLAKDPNGGKGRKKTVQEIFHE H------------STHLMYLNEHLSANKYISSKVPERIKQNVQMNFRSGSRHPPYFIHGG HGSGKSTLLSRIYTELTGWFEHTKVHRVIR-YASATPRSAYNLELLRVICQQLAIILNIP EGYLPKDASFDPLYINNWFQNLLKHCEDLHNEILFLFIDDLHRLNPLDCDIVAALSWLPI SLPWNVF----LVVSTTVPIESLRLTPMQKERFKCADYFFDLSLEQNETKIKHWGVVPSC TEAPPDE-------------------LP---TFAQLVNGLFDAMEQQFGVKGFSRLAIYI TCSEYGLTETELLELLMPTQDADLVIKSNEGDFNFSTFRTIRNQMK--LILREKLMSGKL LIVWRHSICAEITRVRYMTPDITRSIHSELVNLFFPPDGDDSE-DMSTEQHSRKSMHCFT N-EKETKNTALLTAISETERDHCRHRIDDNVTQVLNLGPDISYSIRHVEEAWHHLIKSED TKKLKEIAVCNFDFLLAAVQTVSISYLRCLIEHVRCYILDRD-------IELVYYTIRKS SDVLTRDPMQLGAQLISWLKSVSAH-EGPQALLSVTVQSATAWCDGYTVPLLVPLTGWLP VPLPSQIRC------ITVP-----GPGPVRCIEVSPSKQHLILSPKV---GDPQLWHIM- SNSLVHTFKG-HSGPITYMKVL----SQYLVTASEDTSVIVWDMKTLAMKLRLRE-HIAP ALCATLAL-D---NKYVISGSDDSS--II----VSLLETGKLVTKFDHHRGPVS--ALHM ------SYPSEVLVSSSHDATVCLWSLEN--FTL-------------------------- -----------------LNCIQMS--------------QPILNMQISCDSTFLLAHCADN GLYLRSLTTGTELHALKGHKS---------------------KVRALCIAMDSQRAIVGG EDTRA--------LIFDMHSGRVIRSL-PPNPGAVTAVYVMEKDDYLITAG--GNKITFY SFRNEDSIVNFY---PKKKKTLKKFHRNRLA----------------------------- --LQSTSSPVICFDVSRDSTMAAVAS--SRCVQIWQ------------------------ ------------------LNSPELTSILEGHSATVTCVSFAPNCELVASGSEDKTVNVWS LGLG----TVTATFKGHCTSISSVTF----MMDARRI-ISADRDGLLYV-WIS----DSG MILQSVQGPHKCLSVTNNMK-----FAVCTNGDSSL----RIWSLTR---EDEKYTVSHS D-EITCFIIT----ADSL-----YVITGSRDM----SLKVWQAT---GGKLAQ-VLVGHT DAVTCVAVSVTNKSQVISGSKD-SNLIIWDIHTGEEIHTL---------AGHLGPVTCVK VSADGTTAVSGSDDKTLI--VWETKRGLALTSLQLHVQFTRFDISLECSRIVVQLVDNSC LPIICLHNSPASYIKLP-TYSAPARDVEDLRPAGPKRPARRLLKKEVSL----------- -------DTYTWQKKY-AHLTSSVMMAQVDERLKRRFSVSASMEEISKLAEAKNVESQAT LGPEQAALAQSQHFDQLEALWNKRSPPRRRLNASLSRQSSLVEDRIDSSDEDEFQEERAG M--SKKLALFHASRPLSLSV--DAWNCSSLYSSTSSTNTQY---NQPNHHQQHHYYQHHH RH----------QPDLLREVLLLKKQHSVPTG-------GTSGYSGDPFGGQLKLSSTET DLQALFRHC-TFGTLSCHSRRR--QSSPENEQYHVRRRMSRSIDNLNHEVAVFNQQCRRN -------------------------------------PMSRS------------------ ---------CLMQ---------------- >M_domestica_ENSMODP00000027702 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ADLDQADRGILSGWGWSHGQGPGDGAGTVEQGAEVGWASNVYAVQRRIEPF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------YKGGKVQA--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SQD GQLLFCVCGSGVNVVDATSGNLVRT----------------------------------- ------------------------------------------------------------ ---------------FQQD-----DQEIITAFDLSPNNEILVTGSRA---LLLTQWAWR- EGNATRVWKAVHTAPVASMAFD--PTSTLLATGGCDGAVRVWDLERRYGTHHLRG-SPGV VHLLAFHP-DPE-QLLLFSSAMDCT--IR----VWGLQAGTCLAMLSSHYSTVT--SLAF ------SDDGHTMVSSGRDKICTVWDLKT--RTS-------------------------- -----------------VKTVPVFESVESVVLLPKG--GD-PELGVNTPGLHLLTAGDRG VLRIWEVESGSCVYTQKPV--------------AGEGGPGR-EITHCALVPAAGLIMAVT AEHNI--------LLYDAHNLRLHKQF-AGYNEDVLDVRFLGPEDSHIVVATNSPRLKVF ELETSD-----------------------------------------------------C QILCGHTDIVLALDVFRKGRLFTSCA-KDQSVRIWR------------------------ ---------------------------MN-ATGKVHC----------------------- ----------IAHGSGHTHSIGTISC----SRLKETFLVTGSQDCTIKL-WPL----PEP ITSKKMTKNPNC----------------------------DPFPL-----QAQATQRAHD K-DINSVAVS----PNDK-----LLASGSQDR----TAKLWSLP---DFSLLG-VFSGHR RGVWCVQFSPM-DQVLATASAD-GSLKLWGLQDFSCLKTF---------EGHDASVLRVT FVSRGTQLLSSGSDGLLK--LWTIKTNECVRTLDGHEDKVWGLHCNRQDEAVVTGASDAR ILL--------------------WKDVTETEQAEEQARQEEQILKQQEL----------- -------SNLLQEKQYLRALGLAISLDRPHTVLTVIKAILKEVEGP-------------- ---------------------------------------KKLEEKVLKLRKDQKEALLRF LVTWNTNSR--------------------------------------------------- -----------------------------------------HCHEAQAVLGVLLQHESPE ELLTYEGIQASLEALLPYTERHFQRIGRTLQAAMFLDFLWQTMKLPETSAIPT------- ------------------------------------------------------------ ----------------------------- >X_tropicalis_ENSXETP00000015707 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------YPDPCFG--LFAFSSYAVTRKIEAF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------YKGGKVQI--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NSD GTYILCTCGNKLNILDIATGAVTYT----------------------------------- ------------------------------------------------------------ ---------------IEQD-----DQEDITSFALSPDDEILVTGSRA---LLLKQWDWK- QGTCSRTWKAIHTAPVATMTFD--PTSTLLATGGCDSTIKIWDVIKQYCTHNLKG-SSGV VHLVQFHP-DMS-RLQLFSSSMDYK--IR----LWDLKTSKCLCVMETHFSAVT--SLCF ------SPDGNTMISSGRDKICTVWDLET--KSP-------------------------- -----------------KRTVPVYESVEAVVLFPDS--SDIICQENDSQSLLFLTAGSKG ILRVWDAATAVCVYGQTLPHIAEGNS-------TEEEANEH-SLTHCLLIPGQHQVATVT AEHNI--------LMYDLQNLQLKKQF-AGYNDEVLDVKFLGPSDSHIVVATNSPQLKVF DLETSN-----------------------------------------------------C QILYGHTETVLALDVFKKGLLFASCA-KDRTIRVWR------------------------ ---------------------------MKKATGKVTC----------------------- ----------VAQGSGHTNGVGTISC----SRMKEAFLVSGSQDYTIKL-WKL----PES LANKQSKGNS-G----------------------------DLETL-----LACATEKAHD KRDTIKLWQH----RDSP-----VLSTIQQEQPPKDTIKLWQHR---DSPVLSTILQEQP PKFAHSLYREI-PQNYSSIEIPLDTIKIWHHRDSPVLSTI---------QQEQPPNFAPV PSLLLYPSPLSGSDGLLK--LWTIKTNECVKTLDTHEDKVWGLHCNREDDALVTGSADSA IIL--------------------WKDVTETELAEEQAKEDEAILKQQEL----------- -------SNLLHEKRFLKALGLAISLDQPHTVLTVVKAILQEPHGK-------------- ---------------------------------------DDLEKNIERLRQDQKESILRY CCVWNTNSR--------------------------------------------------- -----------------------------------------NCHEAQSVLSIILTHEPPE SLLQFSGIRGSLESLIPYTERHMQRMGRLLQASMFVDFMWQHMRLTDLPEEDKAPGSI-- ------------------------------------------------------------ ----------------------------- >M_mulatta_ENSMMUP00000010429 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MAETAAGVGRFKANYAVERKIEPF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------YKGGKAQL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------DQT GQHLFCICGTRVNILEVASGVVLRS----------------------------------- ------------------------------------------------------------ ---------------LEQE-----DQENITAFDLSPDDEVLVTASRA---LLLAQWAWR- EGSVTRLWKAIHTAPVATMAFD--PTSTLLATGGCDGAVRIWDIVRHYGTHHFRG-SPGV VHLVAFHP-DPT-RLLLFSSAADAA--IR----VWSLQDRSCLAVLTAHYSAVT--SLTF ------SADGHTMLSSGRDKICVIWDLQS--CQA-------------------------- -----------------TKTVPVFESVEAAVLLPEE---PVSQLGVKSSGLYFLTAGDQG ILRVWEAASGQCVYTQ-----------------ARPPGPGR-ELTHCTLARTAGLLLSAT ADHNL--------LLYEARSLRLQKQF-AGYSEEVLDVRFLGPEDSHVIVASNSPCLKVF ELQTSA-----------------------------------------------------C QILHGHTDIVLALDVFRKGWLFASCA-KDQSVRIWR------------------------ ---------------------------MN-KAGQVIC----------------------- ----------VAQGSGHTHSVGTVCC----SRLKESFLVTGSQDCTVKL-WPL----PKA LLSKNTAPD--N----------------------------GPILL-----QAQTTQRCHD K-DINSVAIA----PNDK-----LLATGSQDR----TAKLWALP---QCQLLG-VFSGHR RGLWCVQFSPM-DQVLATASAD-GTIKLWALQDFSCLKTF---------EGHDASVLKVA FVSRGTQLLSSGSDGLVK--LWTIKNNECVRTLDAHEDKVWGLHCSRLDDRALTGASDSR VIL--------------------WK---VAEQAEEQARQEEQVVRQQEL----------- -------DNLLHEKRYLRALGLAISLDRPHTVLTVIQAIRRDPEAC-------------- ---------------------------------------EKLEATMLRLRRDQKEALLRF CVTWNTNSR--------------------------------------------------- -----------------------------------------HCHEAQAVLGVLLRREAPE ELLAYEGVWAALEALLPYTERHFQRLSRTLQAAAFLDFLWHNMKLPVLAATPTPWETHKE ALP--------------------------------------------------------- ----------------------------- >B_taurus_ENSBTAP00000001564 MLEKPPGHVSTHSDILSLENRCLATLPDLKTLEKPPGHMSAHSDILSSENRCLATLPDLK TLEKPPGHVSAHSDILSLENRCLATLPDLKTLEKPPGHVSAHSDILSLENRCLATLTILK STVSISPLLQNLQISHLAQADLCSLNSSNHLLSEHPASRVQYLSEGRGLLTCPRVSKT-I SAPERVQEAVLGRWSSSGEKK-PEEKEWAEAQMPFYRLSLG-EEEE-VEELALKLTPGDS ESHPEPTEQVLQEVKMVLMSFLCSSLVANVNRNDAAYSTQAFLLKVCSEVARFEPEFVLK ASLYTRQQLNVRDVANKVLAIAAFLPLCRPYLRRYFCAIVQLPSDWIQVARFYELLCREQ EDCLAPLPACLRAAMRDKFSQFDEYQLAKYNPRKHRAKRRPRRPPRPPK-EHTFSETQTY LPRFI-WHIRGEQ-RMFETTYGSVSEKKTEQRFTLKKLVRRLHIHEPAQLVQALLGCRYP SNLQAFSRSRLPGPWDSSRAGKRMKLARPETWERELSLRGNKATVWEELIDSGKLPFMAM LRNLRNLLRVGISARHHELVLQRLQHAKTVIHSRQFPFRFLNAHDSINDLEAQLEKKELP FPSNTQLIKQIIIKNTKYGKKHAYSWQFRQPSRRELRTAMMIPVIYEQLKRKKMKIHKAR QWKCDREMLARYRQALETAVNLSVKHSLPPLPGRTLLVYLTDASADRILPKSNPQGPPLN YVLLLIAMMMVRTEQVELLLCGGGIVKTAVIKAEEGILKTATELQAQVQKS--DES-CEQ SLTTLGKHLLSLATQRVPVDRVIVFGQTTNEKLINAAKQLFWQHVNPKCLFVGVLL-RAS YLCT--DLNPNDVTLSGCTDGILKFIAERGASRLLEHVGQMDKIFKIPPPPGKTGVQSLR PLEENTPSPLAPVSQLGWRSIRLFISSTFRDMHGERDLLLRSLLPALQARVAPYRISLHA IDLRWGITEEETRQNRQLEVCLGE----------VENSQLFVGILGSRYGYVPPNYSLPD HPHFCW----------------AQQYPAGRSVTEMEVMQFLNRGLRLQPSAQPLLYFRDS SFLSSVPDAWKSDF---------------------------------------------I SESEE-------------------------------AAHRISELKSYLSRQEGITCRRYR CEWGGVAAGR---PY--VGGLEEFGQLVLQDVWSMIQKLYLQPGAQPEQPVPIPDDDL-- --------------VQATFQQLKKPRSPARPRLLQDTVRQLMQH------QGRLSLVTGQ SGQGKTAFLASLVSALQAPDGATVAPLVFFHFSGARPDHSLALTLLRRLCAYLHSQLEEP -SALPS-TYRGLVWELQQRLLPKSAQSLRTGQPLVLIVDGADRL--VDQRGQLISDWIPK ILPRWVH----LVLSVSSDSGLGETLEQRQGAHVVALGPLEPSARAQLVREELALYGKRL EESPFNN-------------QMRLLLVKRGSVLPLYLRLVTDHLRLFTLYEQVSERLQTL PAT-----VPLLLQHVLGTLEQEHGPDVLPQALATLEATRSGLTV--DQLHGVLSAWRIL P-RGSKSWEEAVAAGNSGDPYPMGQFAYLVQSLRSLLGE-----G-PLERPGARLCLQDG PLRTAARCRYGKRPELEKTAHLLTAAQLWKTCDPDASGTFRRCPPEALADLPYHLLQSGN RGLLAKF-LTSLHVVAAHLELGLTSQLLEAHALYASSVPGEEQKLPEADVAAFHTFLRQQ APILSRYP-LLLHQQ-----------VANQPLDSPLCRQAPRL---SQRQHLQCMLHWLN KPQTLKHQQS---SSLSLA-----VSSSPTAVAFSPNGQRAAVGTAN---GTVYLLDLR- TWQDERSMVS-GGDGVSSCSFL---SDNALFLTAFDGLLELWDLQHGCRVLQIQA-HQYQ ITGCCLSP-D---RRLLATVCLGGG--LK----LWDVVRGQLASQHT-CPKPLN--CVAF ------HPEGQVIAVGGWAGSFSFFHVDG--LRV-------------------------- ----------------------------TKELGAPG--ASVRTLAFGVPGRVVAVGRLDR MVELWAWQEGARLAAFPAHQG---------------------FVATALFLRSGCQLLTAG EDGKV--------QVWSGSLGRPRGCL-GSPHLSPALSVALSPDGDQVAVGYRADGIRIC RISSAS---------QGAQGQALDVAVSALTWLSPKVLVSGAEDGALQGWLLQGGTLQSL WLLSRHRKPVLGLATSQE--LLAIAS-EDFTVRLWP-RQLLMLPQKT------------- -------------------EDFPRSTELRGHEGPVSCCSFSTDGCRLATGGRDRSLLCWD VRTPKAPVLICSFSACHRDWVTGCAW----TKD--SLLVSCSSDGSVAL-WDP----ESR QQLGHFLGHQHAVSAVVAVEE----HVVSVGRDGTL----KVWDH-Q--GVEMTSIPAHS G-PISHCVAALEPRAAGQPGSELLVVTVGLDG----ATRLWHPL---LVFQTH-TLLGHS GPVSAAAVSET-SGLLLTTSED-GSLRLWQVPKEADDTYR---------PRSPAAITAVA WAPDGSAAVSGNQAGELT--LWQEAK--AVVTVQAPGC-ISALLWYSAHTLIVVSANEKV SEW--------------------QVELQKGSTPRNVSLRLNRVL--QE------------ -------DLGFLTSVGLAPDAHSLILAKADLQLLHMKPGDEPSVIWQSYSEDPMML-STH ---------------QDYGVFVLQSMKLQVLPFSGQKELGEFEECLEFDLNLENPSNTLI SVTQAKPGS---------ESSFLCASSDGMLWNLARCTDEGEWITDNIWQKKAEMPSTQS SETESCIC----------TNTYSWSTVTELKTQQRRKIHSGPVTALHVLPELLVTASKDR DVKLWERPSMRLLGLFQCEGAVSCLEPWLGPDSTLQLAVGDTQGNVYFLSWE-------- ------------------------------------------------------------ ----------------------------- >A_aegypti_AAEL001276-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------MAAIIEEA VFNALRGHHNEKTKLPSPRIIKIYVASLKEDFKEERRLLLEVIGPDLQSVYDDRQIEVEI VDIHFGTGS-GCTVVDLDPYVLEDHLYEIETCHRVSKSVFLIVLLGSRLGNFLLPTKLDS EIFTAI--NKRSTADECECLRKWYQEDAAAGCYVLRTQFRTKERQEWITESRQLSDILEN KINEILKTFPDGGEEGGGGGGSEEVVGAGGISLIDRKRFCDNLKRLKIRALELEIQKGLA CSKENMLAIFRQWDAENGN-----------GPSNESRVEQIKSSLQESLPAENLETLTAP --WTEGGIDPELDSH--ESYLNDFKELMYDKLKNAIDQSLAKDPNGGKGRKKTVQEIFYE H------------STHLMYLNEHLNASKYISSKIPDRIRQNVQQNYRSGSRHPPYFIYGG HGSGKSTLLSHIYTELTGWFEHIKVHRVIR-YASATPRSAYNLELLRVICQQLAIILNIP EGYLPKDASFDPLYINNWFQNLLKHCEDLHNEILFLFIDDLHRLNPLDCDIVAALSWLPI SLPWNVF----LVVSTTVPIDSLKLTPMQKERFKYSDYFFDLSLEQNETIVRK------- ----VDS-------------------SQ---SFEEYVNNIFNAMEKRFGRKGFSKLAIYI TCSEYGLTETEFLELLMPTQDSDALIDTNEGGFNFSTFRTARNEMR--ALLREKLMSGKL LIVWRHSICSEITKVRYMTPDISRSVHSEIVNLFFPPDSEESD-EISSAQNSRKSSHYKK RVLREGDSLGVISMCRKGGKIRIQTQHDDNVTQIITLGPDISYSIRHVEESWHHLIKSDD TKKLKEIAVCNFDFLLAAVQTVSISYLRCLIEHVRCYILDRD-------IELVYYTIRKS SDVLTRDPMQLGAQLISWLKSVAAH-EGPQALLSVTVQSATAWCDGYTVPLLVPLTGWLP VPLPSQIRC------MTVP-----GPGPVRCIEVSPSKQHLILSPKV---GDPQLWHIM- SNSLVHTFKG-HSGPVTYMKVQ----WQYLLTASEDTSVIVWDMQTLALKLRLCE-HIAP VTCCTLAL-D---NKYLITSSEDSS--II----VALFESGKVITKIDHHRGPVT--AIHV ------AMPSEVLVSSSHDGTVCLWSLDN--FTL-------------------------- -----------------LNCIQLP--------------HPVLNFQISCDSIFLLAYCEDN GLYLRALATGTELHALKGHKS---------------------KVRALCIAMDSQRAIVGG EDTRA--------LIYDMHSGRIIRSL-PPNPGPVTAVYIMAKDDYLITAG--GNKITFY SFRNEDSIVNFF---PKKKKTMKKIAKSRVA----------------------------- --LAATSSPVICFDISRDSTTAAVAS--SRCIQIWQ------------------------ ------------------LNTPELTAILEGHTGTVTCVSFAPNCEFVASGSEDKTVNVWS LALG----TIVTTFKGHNTFVTSVTF----LMDSRRI-ISADRESCLFV-WMA----DSG TILQSVQGPFKCLAVTNNMK-----FAVCTNGDTSL----RIWSLTR---EDEKFLVSHS G-EITCFIIT----ADSL-----YLISGSKDM----SLKVWQAS---GGKLAQ-VLVGHT DAVTCVAVSVTNKSQVISGSKD-SNLIIWDIHTGEEIHTL---------AGHLGPVTCVK VSADGTTAVSGSDDKTLI--VWEIKRGLALTSLQLHVQFTRFDISLECSRIVVQLVDSSC LPIICLHNSPASYIKLP-TYSAPARDVEDLRPAGPKRPARRLLKKEVSL----------- -------DTYTWQKKY-AHLTSSVMMAQVDERLKRRFSVSASMEEISKLAESKTMESQQN LGPEQAALAQSQHFDQLEALWNKRSPPRRRVNASLSRQSSLVEDRIESSDEDEFLEERAG T--SKRHK-FISMRPVSLPV--DAWHYSSFFHSS------F---THHHHHNQNQSHQH-- -------------PDLLREVLLLKKQHSTPAPTLPHDDIGLTGSSVES-RRKLKMSSTET DLQSFFGNCTTFGSLYCNARRKHAQQSPECESRAYMRRQSRSIENLR-----YGDEARLR -------------------------------------RKYRS------------------ ---------CLMQ----------------