>H_sapiens_ENSP00000355834 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MAGIAA------------KLAKDRE- -----AAEGLGSHDRAIKYLN-QDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYS SKTRGIEWKRPTEICADPQFIIGGATRTDICQ--GAL--GDCWLLAAIASLTLNEEILAR VVPLNQSFQE-NYAGIFHFQFWQYGEWVEVVVDDRLPTKD-GELLFVHSAEGSEFWSALL EK---AYAKINGCYEALSGGATTEGFEDFTGGIAEWYELK-K---PPPNLFKIIQKALQK GSLLGCSID--------------------------------------------------- IT-------SAA------------------------------------------------ -D--SEAITFQKLVKGHAYSVTGAE-----E-------VES----NG---SLQKLIRIRN PWG-EVEWTGRWNDN-----------CPSWNTIDPEERE-RLTRR-HEDGEFWMSFSDF- LRHYSRLEICN--LTPDTLTS-DT------YK-KWKLTKMDGNWRRGST-------AGGC RNY-P-----------NTFWMNPQYLIKLEEEDE---DEE----DGE------------- ---------SGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYE---V-----P--E----E --LSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGD- -FCIRVFSEKKA------DYQ--A---VDDEIEANLE----------------------- -------------------------------EF---DI---SE-DDIDD-GFRR---LFA QLA-GE---------------------------------------------DAEISAFEL QTI-------------LRRVL-AK------------------------------------ -------------R---------------------------QDI------KSDGFS-IET CKIMVDML-D---SDGSGKLGLKEFYILWTKIQKYQ--------------------KIYR EIDVDRSGTMNSYEMRKALE---------------------------------------- ------EA----GFKMPCQLHQVIVARFADD-QLIIDFDNFVRCLVRLETLFKIFKQLDP ENT--GTIELDLI--S-WLC-FS--VL- >M_mulatta_ENSMMUP00000014584 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MAGIAA------------KLVKDRE- -----AAEGLGSHERAIKYLN-QDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYS SKTRGIEWKRPTEICADPQFIIGGATRTDICQ--GAL--GDCWLLAAIASLTLNEEILAR VVPLNQSFQE-NYAGIFHFQFWQYGEWVEVVVDDRLPTKD-GELLFVHSAEGSEFWSALL EK---AYAKINGCYEALSGGATTEGFEDFTGGIAEWYELK-K---PPPNLFKIIQKALQK GSLLGCSID--------------------------------------------------- IT-------SAA------------------------------------------------ -D--SEAITYQKLVKGHAYSVTGAE-----E-------VES----SG---SLQKLIRIRN PWG-EVEWTGRWNDN-----------CPSWNTIDPEERE-RLTRR-HEDGEFWMSFSDF- LRHYSRLEICN--LTPDTLTS-DT------YK-KWKLTKMDGNWRRGST-------AGGC RNY-P-----------NTFWMNPQYLIKLEEEDE---DEE----DGE------------- ---------SGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIY------------------E --LSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGD- -FCIRVFSEKKA------DYQ--A---VDDEIEANLE----------------------- -------------------------------EF---DI---SE-DDIDD-GFRR---LFA QLA-GE---------------------------------------------DAEISAFEL QTI-------------LRRVL-AK------------------------------------ -------------R---------------------------QDI------KSDGFS-IET CKIMVDML-D---SDGSGKLGLKEFYILWTKIQKYQ--------------------KIYR EIDVDRSGTMNSYEMRKALE---------------------------------------- ------EA----GFKMPCQLHQVIVARFADD-QLIIDFDNFVRCLVRLETLFKIFKQLDP ENT--GTIELDLI--S-WLC-FS--VL- >M_musculus_ENSMUSP00000068895 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MAGIAI------------KLAKDRE- -----AAEGLGSHERAIKYLN-QDYETLRNECLEAGALFQDPSFPALPSSLGYKELGPYS SKTRGIEWKRPTEICADPQFIIGGATRTDICQ--GAL--GDCWLLAAIASLTLNEEILAR VVPPDQSFQE-NYAGIFHFQFWQYGEWVEVVVDDRLPTKD-GELLFVHSAEGSEFWSALL EK---AYAKINGCYEALSGGATTEGFEDFTGGIAEWYELR-K---PPPNLFKIIQKALEK GSLLGCSID--------------------------------------------------- IT-------SAA------------------------------------------------ -D--SEAVTYQKLVKGHAYSVTGAE-----E-------VES----SG---SLQKLIRIRN PWG-QVEWTGKWNDN-----------CPSWNTVDPEVRA-NLTER-QEDGEFWMSFSDF- LRHYSRLEICN--LTPDTLTC-DS------YK-KWKLTKMDGNWRRGST-------AGGC RNY-P-----------NTFWMNPQYLIKLEEEDE---DEE----DGE------------- ---------RGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYE---V-----P--E----E --LTGQTNIHLGKNFFLTTRARERSDTFINLREVLNRFKLPPGEYVLVPSTFEPHKDGD- -FCIRVFSEKKA------DYQ--A---VDDEIEANIE----------------------- -------------------------------EI---DA---NE-EDIDD-GFRR---LFV QLA-GE---------------------------------------------DAEISAFEL QTI-------------LRRVL-AK------------------------------------ -------------R---------------------------QDI------KSDGFS-IET CKIMVDML-D---EDGSGKLGLKEFYILWTKIQKYQ--------------------KIYR EIDVDRSGTMNSYEMRKALE---------------------------------------- ------EA----GFKLPCQLHQVIVARFADD-ELIIDFDNFVRCLVRLETLFKIFKQLDP ENT--GTIQLNLA--S-WLS-FS--VL- >B_taurus_ENSBTAP00000044733 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MAGIAA------------KLAKDRE- -----AAEGLGSHERAVKYLN-QDYAALRDECLEAGALFQDPSFPALPSSLGFKELGPYS SKTRGIEWKRPTEICDNPQFITGGATRTDICQ--GAL--GDCWLLAAIASLTLNEEILAR VVPLDQSFQE-NYAGIFHFQFWQYGEWVEVVVDDRLPTKD-GELLFVHSAEGSEFWSALL EK---AYAKINGCYEALSGGATTEGFEDFTGGIAEWYELR-K---APPNLFRIIQKALQK GSLLGCSID--------------------------------------------------- IT-------SAA------------------------------------------------ -D--SEAITFQKLVKGHAYSVTGAE-----E-------VES----RG---SLQKLIRIRN PWG-EVEWTGQWNDN-----------CPNWNTVDPEVRE-TLTRQ-HEDGEFWMSFNDF- LRHYSRLEICN--LTPDTLTS-DS------YK-KWKLTKMDGNWRRGST-------AGGC RNY-P-----------NTFWMNPQYLIKLEEEDE---DQE----DGE------------- ---------SGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYE---V-----P--E----E --LTGQTNIHLSKKFFLTTRARERSDTFINLREVLNRFKLPPGEYIVVPSTFEPNKDGD- -FCIRVFSEKKA------DYQ--V---VDDEIEANID----------------------- -------------------------------EI---DI---SE-DDIDD-GFRR---LFA QLA-GE---------------------------------------------DAEISAFEL QTI-------------LRRVL-AK------------------------------------ -------------R---------------------------QDI------KSDGFS-IET CKIMVDML-D---SDGSGKLGLKEFYILWTKIQKYQ--------------------KIYR EIDVDRSGTMNSYEMRKALE---------------------------------------- ------EA----GFKMPCQLHQVIVARFADD-DLIIDFDNFVRCLIRLETLFRIFKQLDP ENT--GMIQLDLI--S-WLS-FS--VL- >P_troglodytes_ENSPTRP00000003379 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MAGIAA------------KLAKDRE- -----AAEGLGSHERAIKYLN-QDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYS SKTRGIEWKRPTEICADPQFIIGGATRTDICQ--GAL--GDCWLLAAIASLTLNEEILAR VVPLNQSFQE-NYAGIFHFQFWQNSEWVDV------------------------------ ---------INGCYEALSGGATTEGFEDFTGGIAEWYELK-K---PPPNLFKIIQKALQK GSLLGCSID--------------------------------------------------- IT-------SAA------------------------------------------------ -D--SEAITFQKLVKGHAYSVTGAE-----E-------VES----NG---SLQKLIRIRN PWG-EVEWTGRWNDN-----------CPSWNTIDPEERE-RLTRR-HEDGEFWMSFSDF- LRHYSRLEICN--LTPDTLTS-DT------YK-KWKLTKMDGNWRRGST-------AGGC RNY-P-----------NTFWMNPQYLIKLEEEDE---DEE----DGE------------- ---------SGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYE---V-----P--E----E --LSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGD- -FCIRVFSEKKA------DYQ--A---VDDEIEANLE----------------------- -------------------------------EF---DI---SE-DDIDD-GFRR---LFA QLA-GE---------------------------------------------DAEISAFEL QTI-------------LRRVL-AK------------------------------------ -------------R---------------------------QDI------KSDGFS-IET CKIMVDML-D---SDGSGKLGLKEFYILWTKIQKYQ--------------------KIYR EIDVDRSGTMNSYEMRKALE---------------------------------------- ------EA----GFKMPCQLHQVIVARFADD-QLIIDFDNFVRCLVRLETLFKIFKQLDP ENT--GTIELDLI--S-WLC-FS--VL- >P_pygmaeus_ENSPPYP00000000189 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MAGIAA------------KLAKDRE- -----AAEGLGSHERAIKYLN-QDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYS SKTRGIEWKRPTEICADPQFIIGGATRTDICQ--GAL--GDCWLLAAIASLTLNEEILAR VVPLNQSFQE-NYAGIFHFQ---------------------------------------- ---------INGCYEALSGGATTEGFEDFTGGIAEWYELK-K---PPPNLFKIIQKALQK GSLLGCSID--------------------------------------------------- IT-------SAA------------------------------------------------ -D--SEAITFQKLVKGHAYSVTGAE-----E-------VES----NG---SLQKLIRIRN PWG-EVEWTGRWNDN-----------CPSWNTIDPEERE-RLTRR-HEDGEFWMSFSDF- LRHYSRLEICN--LTPDTLTS-DT------YK-KWKLTKMDGNWRRGST-------AGGC RNY-P-----------NTFWMNPQYLIKLEEEDE---DEE----DGE------------- ---------SGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYE---N-----P--D----E --LSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGD- -FCIRVFSEKKA------DYQ--A---VDDEIEANLE----------------------- -------------------------------EF---DI---SE-DDIDD-GFRR---LFA QLA-GE---------------------------------------------DAEISAFEL QTI-------------LRRVL-AK------------------------------------ -------------R---------------------------QDI------KSDGFS-IET CKIMVDML-D---SDGSGKLGLKEFYILWTKIQKYQ--------------------KIYR EIDVDRSGTMNSYEMRKALE---------------------------------------- ------EA----GFKMPCQLHQVIVARFADD-QLIIDFDNFVRCLVRLETLFKIFKQLDP ENT--GTIELDLI--S-WLC-FS--VL- >R_norvegicus_ENSRNOP00000046509 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MAGIAM------------KLAKDRE- -----AAEGLGSHERAIKYLN-QDYETLRNECLEAGALFQDPSFPALPSSLGFKELGPYS SKTRGIEWKRPTEICADPQFIIGGATRTDICQ--GAL--GDCWLLAAIASLTLNEEILAR VVPLDQSFQE-NYAGIFHFQFWQYGEWVEVVVDDRLPTKD-GELLFVHSAEGSEFWSALL EK---AYAKINGCYEALSGGATTEGFEDFTGGIAEWYELR-K---PPPNLFKIIQKALEK GSLLGCSID--------------------------------------------------- IT-------SAA------------------------------------------------ -D--SEAVTYQKLVKGHAYSVTGAE-----E-------VES----SG---SLQKLIRIRN PWG-QVEWTGKWNDN-----------CPSWNTVDPEVRA-NLTER-QEDGEFWMSFSDF- LRHYSRLEICN--LTPDTLTC-DS------YK-KWKLTKMDGNWRRGST-------AGGC RNY-P-----------NTFWMNPQYLIKLEEEDE---DDE----DGE------------- ---------RGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYE---V-----W--A----E DGLTGQTNIHLSKNFFLTTRARERSDTFINLREVLNRFKLPPGEYVLVPSTFEPHKNGD- -FCIRVFSEKKA------DYQ--T---VDDEIEANIE----------------------- -------------------------------EI---EA---NE-EDIGD-GFRR---LFA QLA-GE---------------------------------------------DAEISAFEL QTI-------------LRRVL-AK------------------------------------ -------------R---------------------------EDI------KSDGFS-IET CKIMVDML-D---EDGSGKLGLKEFYILWTKIQKYQ--------------------KIYR EIDVDRSGTMNSYEMRKALE---------------------------------------- ------EA----GFKLPCQLHQVIVARFADD-ELIIDFDNFVRCLVRLEILFKIFKQLDP ENT--GTIQLDLI--S------------ >O_anatinus_ENSOANP00000002306 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MSGIAA------------KVAKDRE- -----AAQGLGTHQKAIKYLN-QDYESLKSDCLQSGKLFQDPSFPAITSSLGFKELGPNS SKTQGIVWKRPAEICSNPQFIVGGATRTDICQ--GAL--GDCWLLAAIASLTLNEEVLSR VVPENQSFQD-NYAGIFHFQFWQYGEWVEVVVDDRLPTKN-GELLFVHSAEGSEFWSALL EK---AYAKVNGCYEALSGGATTEGFEDFTGGIAEWYELK-K---APDNLFKIIQKALQK GSLLGCSID--------------------------------------------------- IT-------SAS------------------------------------------------ -E--TEAVTFQKLVKGHAYSVTGAE-----E-------VSC----RG---SMEKLIRIRN PWG-EVEWTGKWNDN-----------CPNWNSINPEVKE-RLTRR-HEDGEFWMSFRDF- LRHYSRLEICN--LTPDTLTS-ET------FK-KWSLSKLDGNWRRGST-------AGGC RNY-P-----------NTFWMNPQYLIKLEEEDE---DPE----DVE------------- ---------KGCTFLVGLIQKHRRRQRKMGQDMHTIGFSIYE---V-----P--K----Q --FSGQTNIHLNKNFFLTNKARERSDTFINLREVLNRFKLPPGEYIIVPSTFEPNKDGD- -FCLRVFSEKNA------NSQ--I---VDDEIEANLE----------------------- -------------------------------EPHPNDV---DE-DSIDA-GFKR---LFG QLA-GE---------------------------------------------DAEISAFEL QTI-------------LKKVL-AK------------------------------------ -------------R---------------------------QDI------KSNGFS-IET CKIMVDLL-D---TDGSGKLGLKEFFILWTKIQNYQ--------------------KIYR EIDADNSGTMNAYEMRKALE---------------------------------------- ------EA----GYKLPRQLHQVIIARFADD-QLIIDFDNFVRCLVRLETLFKVFKQLDT QKT--GTIELNLI--T-WLC-FS--VL- >M_domestica_ENSMODP00000035211 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------AMSGIAA------------KVVRDRE- -----AAAGLGTHEQAVKYLN-QDYETLLSECLEEGKLFQDPHFPAIGSSLGFKELGPYS SKTQGIVWKRPTEICSDPQFIVEGATRTDICQ--GAL--GDCWLLAAIASLTLNEEILAR VVPKNQSFQD-NYAGIFHFQFWQYGEWVDVVVDDRLPTKN-DELLFVHSAEGSEFWSALL EK---AYAKVNGCYEALSGGATTEGFEDFTGGIAEWYELK-K---APDNLFIIIQKALQK GSLLGCSID--------------------------------------------------- IT-------SAA------------------------------------------------ -D--SEAVTFQKLVKGHAYSVTGAE-----E-------VDF----RG---SLQKLIRIRN PWG-EVEWTGKWSDS-----------CPNWNSIDPDERE-RLARR-SEDGEFWMSFSDF- LRHYSRLEICN--LTPDTLIS-DD------YK-KWRLTKMDGTWRRGST-------AGGC RNY-P-----------NTFWMNPQYMIKLEEEDE---DDD----GSE------------- ---------PGCTFLVGLIQKHRRRQRKMGEDMHTIGFSIYE---V-----R--RESFLE --FSGRTNLHLNKNFFLTTRARERSDTFINLREVLNRFKLPAGEYVIVPSTFEPHKNGD- -FCLRVFSETKT------DSQ--V---VDDEIEATLE----------------------- -------------------------------EN---DV---DE-DGIED-SFRR---LFA QLA-GE---------------------------------------------DAEISAFEL QTI-------------LRRVL-AK------------------------------------ -------------R---------------------------PDI------KSDGFS-IET CKIMVDML-D---FDGSGKLGLKEFYLLWSKIQKYQ--------------------KIYK EMDVDRSGTMNAYEMRKALE---------------------------------------- ------EA----GFKLPYQLHQVIVARFADD-ELIIDFDNFVRCLVRLETLFKVFKQLDP ENT--GTIELDLT--R-WLC-FS--VL- >C_familiaris_ENSCAFP00000020459 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------EICDDPQFIVGGATRTDICQ--GAL--GDCWLLAAIASLTLNEEVLAR VVPPNQSFQE-NYAGIFHFQFWQYGEWVEVVVDDRLPTKN-GELLFVHSAEGSEFWSALL EK---AYAKINGCYEALSGGATTEGFEDFTGGIAEWYELR-K---APPDLFRIIQKALQK GSLLGCSID--------------------------------------------------- IT-------SMA------------------------------------------------ -D--SEAITFQKLVKGHAYSVTGAE-----E-------VES----GG---SLQKLIRIRN PWG-EVEWTGKWNDN-----------CPNWNTVDPEVRE-RLTRR-HEDGEFWMSFSDF- LRHYSRVEICN--LTPDTLTS-ES------YK-KWKLTKMDGSWRRGST-------AGGC RNY-P-----------NTFWMNPQYVIKLEEEDE---DQE----DGE------------- ---------RGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYE---F-----I--H----Q --MTGQTNIHLSRNFFLTHRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGD- -FCVRVFSEKKA------DYQ--V---VDDEIEADLE----------------------- -------------------------------EI---DA---SE-DDIDD-GFRR---LFA QLA-GE---------------------------------------------DAEISAFEL QTI-------------LRRVL-AK------------------------------------ -------------R---------------------------QDI------KSDGFS-IET CKIMVDML-D---SDGSGKLGLKEFYVLWTKIQKYQ--------------------KIYR EIDVDRSGTMNSYEMRKALE---------------------------------------- ------EA----GFKLPCQLHQVIVARFADD-ELIIDFDNFVRCLVRLETLFRIFKQLDP EGS--GTIELDLI--S-WLC-FS--VL- >A_carolinensis_ENSACAP00000003532 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LRIMSGIAA------------KVAKERE- -----VAQGLGSNQKAVKYLQ-QDFGALRAECLEAGGLFQDPCFPAAAPALGFKELGPHA AKTKGIVWKRPTELCSNPQFIVGGATRTDICQ--GAL--GDCWLLAAIASLTLNEEILAR VVPSDQSFQD-RYAGIFHFQFWQYGEWTDVVVDDRLPTKN-GELLFVHSAEGTEFWSALL EK---AYAKVNGSYEALSGGSTTEGFEDFTGGIAEWYELR-K---APPNLFRIIQKALQK GSLLGCSID--------------------------------------------------- IT-------SAA------------------------------------------------ -E--TEAVTTQKLVKGHAYSVTGAE-----E-------VSF----RG---SLQKLIRIRN PWG-EVEWTGKWNDN-----------CPSWSNVDPEVRD-RLTKK-HEDGEFWMSFDDF- LRHYSRLEICN--LTPDTLTN-DN------YK-KWSLSLMDGNWRKGST-------AGGC RNY-P-----------DSFWMNPQYLIKLEEEDE---DPD----DPE------------- ---------KGCTFLIGLIQKHRRKQRKMGEDMHTIGFAIYE---A-----S--F----P --FSGQTNVHLSKNFFLTNRAKERSNTFINLREVLNRFKLPSGEYIIVPSTFEPNKNGD- -FCLRVFSEKSA------DSQ--Y---VSDSSPLQLTV---------------------- -------------------------------KK---EV---TE-DEIEP-SFKK---LFG QLA-GG---------------------------------------------DAEISAFEL CGI-------------LKKVM-AK------------------------------------ -------------R---------------------------QDI------KSDGFS-IET CKIMVDLL-D---TDGSGKLGLKEFHILWTKIQKYQ--------------------KIYR EMDVDSSGTMNAYEMRKALE---------------------------------------- ------QA----GFKLDCQLHQVIVARFADE-QLIIDFDNFVRCLIRLETLFKIFKKLDT EKT--GTVQMNL---------------- >G_gallus_ENSGALP00000015225 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------AMAGMAA------------ALAKERA- -----AAAGAGRHGQAVPYVG-QDFGALRRECLQGGRLFHDPSFPAGPAALGYRELGPNS YKTKGVVWCRPTELCSCPRFIAGGATRTDICQ--GAL--GDCWLLAAIASLTLNEEILAR VVPRDQSFQD-EYAGIFHFQFWQYGEWVDVVVDDRLPTKN-GELLFVHSAEGSEFWSALL EK---AYAKLNGSYEALSGGTTTEGFEDFTGGIAEWYELQ-K---APPNLFKIIQKALQK GSLLGCSID--------------------------------------------------- IT-------SAA------------------------------------------------ -E--TEAVTSQKLVKGHAYSVTGAE-----E-------VNF----RG---SIQKLIRIRN PWG-EVEWTGKWNDN-----------CPNWSGVDPEVRE-RLTRR-HEDGEFWMAFNDF- LRHYSRLEICN--LTPDTLAS-DR------YK-KWSLLKLDGNWRRGAT-------AGGC RNY-P-----------NTFWTNPQYLIKLEEEDE---DPD----DPE------------- ---------GGCTFLIGLIQKHRRKQRKMGEDMHTIGFAIYE---V-----P--P----E --FSGQTNIHLSKNFFLTNKAREKSNTFINLREVLNRFKLPAGEYIIVPSTFEPNLNGD- -FCLRVFSEKNA------NST--V---IDDEIEANFE----------------------- -------------------------------ET---EI---DE-DDIEP-SFKK---LFG QLA-GS---------------------------------------------DAEISAFEL RNI-------------LNKIL-AK------------------------------------ -------------R---------------------------QDI------KSDGFS-IET CKIMVDLL-D---NDGSGKLGLKEFHTLWTKIQKYQ--------------------KIYR EIDVDRSGTMNSYEMRRALE---------------------------------------- ------AA----GFKLNCQLHQIIVARFADE-DLIIDFDNFVRCLIRLETLFKMFRKLDT EKT--GTIELNLI--N-WLF-FT--VI- >G_gorilla_ENSGGOP00000007856 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MAGIAA------------KLAKDRE- -----AAEGLGSHERAIKYLN-QDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYS SKTRGIEWKRPTXXXXXXXXXXXXXXXXXXXX--XXX--XDCWLLAAIASLTLNEEILAR VVPLNQSFQE-NYAGIFHFQXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXX XX---XXXXINGCYEALSGGATTEGFEDFTGGIAEWYELK-K---PPPNLFKIIQKALQK GSLLGCSID--------------------------------------------------- XX-------XXX------------------------------------------------ -X--XXXXXXXXXXXXXXXXXXXXX-----X-------VES----NG---SLQKLIRIRN PWG-EVEWTGRWNDN-----------CPSWNTIDPEERE-RLTRR-HEDGEFWMSFSDF- LRHYSRLEICN--LTPDTLTS-DT------YK-KWKLTKMDGNWRRGST-------AGGC RNY-P-----------NTFWMNPQYLIKLEEEDE---DEE----DGE------------- ---------SGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYE---V-----P--E----E --LSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGD- -FCIRVFSEKKA------XXX--A---VDDEIEANLE----------------------- -------------------------------EF---DI---SE-DDIDX-GFRR---LFA QLA-GE---------------------------------------------XXXXXXXXX XXX-------------XXXXX-XX------------------------------------ -------------X---------------------------QDI------KSDGFS-IET CKIMVDML-D---SDGSGKLGLKEFYILWTKIQKYQ--------------------KIYR EIDIDRSGTMNSYEMRKALE---------------------------------------- ------EA----GFKMPCQLHQVIVARFADD-QLIIXFDNFVRCLVRLETLFKIFKQLDP ENT--GTIELDLI--S-WLC-FS--VL- >E_caballus_ENSECAP00000010724 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------DCWLLAAIASLTLNEEILAR VVPLNQSFQE-NYAGIFHFQFWQYGEWVEVVVDDRLPTKD-GELLFVHSAEGSEFWSALL EK---AYAKINGCYEALSGGATTEGFEDFTGGIAEWYELR-K---APSNLFKIIQKALQK GSLLGCSID--------------------------------------------------- IT-------SAA------------------------------------------------ -D--SEAITFQKLVKGHAYSVTGAE-----E-------VES----SG---SLQKLIRIRN PWG-EVEWTGRWNDN-----------CPNWNTVDPEVRE-RLTRR-HEDGEFWMSFSDF- LRHYSRLEICN--LTPDTLTS-DS------YK-KWKLSKMDGNWRRGST-------AGGC RNY-P-----------NTFWMNPQYVIKLEEEDE---DQD----DGE------------- ---------SGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYE---V-----P--E----E --LLGQTNIHLSKNFFLTHRARERSDTFINLREVLNRFKLPPGEYIIVPSTFEPNKDGD- -FCIRVFSEKKA------DYH-------RDFCNVSFH----------------------- -------------------------------PH---LP---SR-RDTTP-QRREVCSLLS QDL-GG---------------------------------------------DAEISAFEL QTI-------------LRRIL-AK------------------------------------ -------------R---------------------------QDI------KSDGFS-IET CKIMVDML-D---LDGTGKLGLKEFYILWTKIQKYQ--------------------KIYR EIDADRSGTMNSYEMRKALE---------------------------------------- ------EA----GFKLPCQLHQVIVARFADD-QLIIDFDNFVRCLVRLETLFKIFKELDP ENT--GTIQLDL---------------- >T_guttata_ENSTGUP00000011275 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------AMAGMAE------------ALAKERA- -----AAAGAGRHDRAVPYLG-QRFGALRQECLQEGRLFQDPSFPAGPTALGYRELGPRS HKTQGVVWRRPTELCPNPQFIAGGATRTDICQ--GAL--GDCWLLAAVASLTQNEEIPAC VIPKDQSFQD-KYAGIFHFQVSSVALYVSIQTEKRRHLK---RVAFCHQGLGSSISCALC TSEGLAGASASVCKEHQSIPTTTEGFEDFTGGIAEWYELQ-K---PSPNLFKVIQKAAQR GSLLGCSIA--------------------------------------------------- IT-------SAA------------------------------------------------ -E--TEAVTSQKLVKGHAYSVTGAE-----E-------VNF----RG---TVQKLIRIRN PWG-EVEWTGKWNDN-----------CPNWSGVDPEVRE-RLTRR-HEDGEFWMAFNDF- LRHYSRLEICN--LTPDTLAS-DR------YK-KWSLQKLDGNWRRGAT-------AGGC RNY-P-----------DTFWTNPQYLIKLEEEDE---DPD----DPE------------- ---------GGCTFLIGLIQKHRRKQRKMGEDMHTIGFAIYEARKA-----D--R----S --FSGQTSIHLSKNFFLTNKAREKSNTFINLREVLNRFKLPAGEYIIVPSTFEPNKNGD- -FCLRVFSEKNA------NST--V---IDDEIEGNFD----------------------- -------------------------------ET---ET---SE-DDIEP-SFKK---LFG QLA-GN---------------------------------------------DAEISAFEL RSI-------------LNKIL-AK------------------------------------ -------------R---------------------------QDI------KSDGFS-IET CKIMVDLL-D---NDGSGKLGLKEFHTLWTKIQKYQ--------------------KIYR EIDVDRSGTMNSYEMRRALE---------------------------------------- ------TA----GFKLNCQLHQVIVARFADE-DLVIDFDNFVRCLIRLETLFKMFRKLDT EKS--GTIELNLV--N-WLC-FT--VI- >O_cuniculus_ENSOCUP00000003984 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ELSPEPQFIVGGATRTDICQ--GAL--GDCWLLAAIASLTLNEEVLAR VVPLDQSFQE-NYAGIFRFQFWQYGEWVEVVVDDRLPTKD-GELLFVHSAEGSEFCSALL EK---AYAKINGCYEALSGGATTEGFEDFTGGIAEWYELK-K---APPDLFRIIQKALQK GSLLGCSID--------------------------------------------------- IT-------SAA------------------------------------------------ -D--SEAITLQKLVKGHAYSVTGAE-----E-------VES----AG---SLQKLIRIRN PWG-EVEWTGRWNDN-----------CPNWNTVDPEVRE-RLAER-HEDGEFWMSFSDF- LRHYSRLEICN--LTPDTLTS-DT------YK-KWKLTKMDGNWRRGST-------AGGC RNY-P-----------NTFWMNPQYVIKLEEEDE---DQE----DGE------------- ---------SGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYE---V-----P--E----E --LGGQTNIHLGKNFFLTTRARERSDTFINLREVLNRFKLPLGEYILXXXXXXXXXXXX- -XXXXXXXXXXX------XXX--A---VDDEIEADLE----------------------- -------------------------------EA---DV---SE-DDIDD-GFRR---LFA QLA-GE---------------------------------------------DAEISAFEL QNI-------------LRRVL-AK------------------------------------ -------------R---------------------------QDI------KTDGFS-IET CKIMVDML-D---SDGTGKLGLKEFYVLWTKIQKYQ--------------------KIYR EIDVDRSGTMNSYEMRKALE---------------------------------------- ------EA----XXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXIFMQLNP DNT--GMIQLDLI--S-WLC-FS--VL- >D_rerio_ENSDARP00000028094 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MSGIAT------------KLQKNRA- -----RAAGIGTNAQAAKFLN-QDYEALKRECLESGRLFQDGMFEANVSALGFKELGPNS SKVRGVEWLRPKQLTSNPTFISGGATRTDICQ--GAL--GDCWLLAAIASLTLNQDVFAR VVPAGQSFDG-DYAGIFHFQFWQFGEWVDVVIDDRLPARK-GELLFVHSAEGSEFWSALL EK---AYAKLNGCYEALSGGTTTEGFEDFTGGIAEVHELP-K---AGPNLFKTIQKALSW GSLLGCSID--------------------------------------------------- IT-------SSS------------------------------------------------ -D--SEAITSQKLVKGHAYSVTGAE-----E-------VEY----RG---DLTKLIRIRN PWG-QVEWTGPWSDG-----------SSEWRQISDSDRE-RLSSK-AEDGEFWMSFSDF- MRHYSRVEICN--LTPDALTD-ES------VN-KWALSKFDGNWRNGST-------AGGC RNY-P-----------NSFWMNPQFLIKLEEQDD---DPT----DNE------------- ---------AGCSFVVGLIQKNRRKMRKVGEDMNTIGFAIYE---V-----P--D----E --FVGQRNVHLDRNFFVRHASAARSETFINLREVCSRFCLPPGEYLIVPSTFEPNKDGD- -FCVRVFSEKQA------EFQ--E---LDDPVESKVA----------------------- -------------------------------E--I-EI---KE-GDIDS-RFRN---LFK QLA-GA---------------------------------------------DSEISAFEL QKI-------------LNNVI-AK------------------------------------ -------------R---------------------------KDI------KTDGFS-LET CRNMVNLL-D---KDGTGKLGLLEFKILWTKIELFV--------------------DVYS KNDKDQSGTMSSMEMREAVE---------------------------------------- ------KA----GFSLNNALHQILVARYSEP-NLTIDFDNFVACLIRLECMFKAFKVLDK DKN--GTVELNMM--E-WLV-LT--SFL >T_rubripes_ENSTRUP00000018376 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EAQRGTSLTADSSSTFSGLHHLTMSGIAA------------KLRHNRD- -----RAQGIGTNDHAQKYLN-QDFESLRDDCLERGVLFEDDYFEALPSSLGYDELGPSS YKVRGIAWKRPTELCSNPQFIVENASRTDICQ--GAL--GDCWLLAAIASLTLNKQVLSR VVPHDQSFED-NYAGIFHFEFWQFGEWVDVVVDDRLPTKD-GKLLFVHSAEGSEFWSALL EK---AYAKVNGCYEALSGGSTTEGFEDFTGGISERHDLG-N---ADPHLFHIIKKALER GSLLGCSID--------------------------------------------------- IT-------NAS------------------------------------------------ -D--SEAVTYRKLVKGHAYSVTGAD-----Q-------VEY----GG---EAVHLIRIRN PWG-QVEWNGAWSDD-----------SSEWRYVSSDDRA-RLTNR-SDDGEFWMSFSDF- LRQYSRLEICN--LTPDALTG-DD------YK-KWAETEFEDTWRRGSS-------AGGC RNY-P-----------NSFWMNPQFVIKLEEVDD---DPD----EGQ------------- ---------EGCTFIVGLMQKNRRRMRKMGEDMETIGFAIYE---L-----P--E----E --CSGLRNVHLKRDFFLRNASAARSETFINLREVCNHFCLPPGEYLIIPSTFEPNKNAD- -FYLRVFSEKNA------DFQ--E---IDDAVESHVE----------------------- -------------------------------Q--I-DI---DE-DDISS-HFKS---LFG QLA-GD---------------------------------------------DVEICAFEL QKI-------------LSRVV-TR------------------------------------ -------------R---------------------------SDI------KTDGFT-LTT CRTMVNLL-D---KDGSGKLGLVEFRILWAKIEKFL--------------------EIYK DRDMDQSGCMSAPEMRMAVE---------------------------------------- ------AA----GFSLNNPLHQIIVARYSQ--DLHIDFDNFVCCLIRLELLFNTFKALDE DGD--GMISLSFF--E-WLD-MA--ML- >T_nigroviridis_ENSTNIP00000003975 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------QETPTSTTQESSHRQQRPTLCSLQHLNMSGIAA------------KLQHHRD- -----RAQGFGTASQAQKYLN-QDFESLRESCLERGELFQDEYFEALPSSLGYNELGPGS YKVRGITWRRPTELCSKPQFIVENASRTDICQ--GAL--GDCWLLAAIASLTLNKQVLSR VVPHDQSFEE-NYAGIFHFQFWQFGEWVDVVVDDRLPTRD-GELLFVHSAEGSEFWSALL EK---AYAKVNGCYEALSGGSTTEGFEDFTGGIAERHDLS-S---ADPHLFHIIKKALER GSLLGCSID--------------------------------------------------- IT-------SAS------------------------------------------------ -D--SEAITYRKLVKGHAYSVTGAD-----Q-------VEY----RG---EAVQLVRIRN PWG-QVEWNGAWSDD-----------SSEWRYVSSDDRE-RLTNR-SEDGEFWMSFSDF- LRQYSRLEICN--LTPDALTG-DE------YK-KWAETEFEDTWRRGST-------AGGC RNY-P-----------NSFWLNPQFVIKLEEVDD---DPG----EDQ------------- ---------EGCTFIVGLMQKNRRRLRKMGEDMETIGFAIYE---L-----P--E----E --YSGLKNVHLKKNFFLSSYATARSETFINLREVCSRFCLPPGEYLIVPSTFEPNKNAD- -FYLRVFSEKNA------DFQ--E---IDDSVKCHVE----------------------- -------------------------------Q--I-DI---DE-DDISN-HFKS---LFG KLA-GQ---------------------------------------------DVEISAFEL QRI-------------LSRVV-MK------------------------------------ -------------R---------------------------SDI------KSDGFT-LST CRTMVNLL-D---KDGSGKLGLVEFRILWAKIDKFL--------------------NIYK ERDTDQSGCMSAPEMRMAVE---------------------------------------- ------AA----GFSLNNPLHQLIVARYSQ--DLHIDFDNFVCCLIRLELLFNTFKALDV DGD--GVISLGFY--Q-ATL-CA--DYL >D_rerio_ENSDARP00000069095 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MSGVAS------------TLAKKRA- -----LAAGFGTNSNAVKYLN-QSFETLRSECLSRGELFCDPAFPAAPEALGFNELGPRS SKTRGVEWKRPGQLTSSPEFIVGGATRTDICQ--GALA-GDCWLLAAIASLTLNEDVLAR VVPSDQGFGQ-DYAGIFHFQFWQFGEWVDVVVDDRLPTRD-GELLFVHSVTGSEFWSALL EK---AYAKVNGCYEALSGGSTTEGFEDFTGGIAEMYELK-S---APTNLFQIIKKALDS GALLGCSID--------------------------------------------------- IT-------SAA------------------------------------------------ -D--SEAVTYQKLVKGHAYSLTGAT-----E-------VNY----RS---RKEKLVRVRN PWG-QVEWTGAWSDN-----------SSEWNAVDPSERE-N--VK-SEDGEFWMSFSDF- VRQYSRLEICT--LTPDTLTS-DS------LK-QWSVCKFDGTWRKGST-------AGGC RNH-P-----------YTFWMNPQFKIKLEEEDD---DPD----DNE------------- ---------VGCSVVIGLIQKNRRKMRKAGEDMHTIGYAIYE---V-----P--S----Q --FHGQKEVHLDKNYFLTHAQKARSETFINLREVSTRFKLPPGEYLIVPSTFDPHKNGD- -FCVRVFSEKQS------EMQ--Q---CDDPIEANVDD---------------------- -------------------------------E----MV---SE-EEVDS-GFRG---LFT KLA-GD---------------------------------------------DMEISASEL RTI-------------FNKIV-AK------------------------------------ -------------R---------------------------TDI------KTDGFS-LDT CRVMVNLM-D---ESGNGKLGLTEFATLWKKIQKYL--------------------GIYK KNDMDGSGCMSTPEMRMALK---------------------------------------- ------EA----GFSLNDCIHQSLAARYGDA-DMTIDFDNFVSCVMRLEMMFKVFKRMDI DHS--GFIELDFF--Q-WLS-FA--MI- >D_rerio_ENSDARP00000043450 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MSGVAS------------TLAKKRA- -----LAAGFGTNSNAVKYLN-QNFETLRSECLSRGELFCDPAFPAAPEALGFNELGPRS SKTRGVEWKRPGQLNSSPEFIVGGATRTDICQ--GALA-GDCWLLAAIASLTLNEDVLAR VVPSDQGFGQ-DYAGIFHFQFWQFGEWVDVVVDDRLPTRD-GELLFVHSVTGSEFWSALL EK---AYAKVNGCYEALSGGSTTEGFEDFTGGIAEMYELK-S---APTNLFQIIKKALDS GALLGCSID--------------------------------------------------- IT-------SAA------------------------------------------------ -D--SEAVTYQKLVKGHAYSLTGAT-----E-------VNY----RS---RKEKLVRVRN PWG-QVEWTGAWSDN-----------SSEWNAVDPSERE-N--VK-SEDGEFWMSFSDF- VRQYSRLEICT--LTPDTLTS-DS------LK-HWSVCKFDGTWRKGST-------AGGC RNH-P-----------YTFWMNPQFKIKLEEEDD---DPD----DNE------------- ---------VGCSVVIGLIQKNRRKMRKAGEDMHTIGYAIYE---V-----P--S----Q --FHGQKEVHLDKNYFLTHAQKARSETFINLREVSTRFKLPPGEYLIVPSTFDPHKNGD- -FCVRVFSEKQS------EMQ--Q---CDDPIEANVDD---------------------- -------------------------------E----MV---SE-EEVDS-GFRG---LFT KLA-GD---------------------------------------------DMEISASEL RTI-------------FNKIV-AK------------------------------------ -------------R---------------------------TDI------KTDGFS-LDT CRVMVNLM-D---ESGNGKLGLTEFATLWKKIQKYL--------------------GIYK KNDMDGSGCMSTPEMRMALK---------------------------------------- ------EA----GFSLNDCIHQSLAARYGDA-DMTIDFDNFVSCVMRLEMMFKVFKRMDI DHS--GFIELDFF--Q-WLS-FA--MI- >A_carolinensis_ENSACAP00000001318 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------MMPFGGMAA------------RLERDRL- -----RAEGVGSHQNAVKYLG-QDYETLKQECLESGRLFEDPQFPAIPSVLGFKELGPNS GKTQGVRWKRPSEIVDDPQFIVGGATRTDICQ--GAL--GDCWLLAAIGSLTLNEDLLHR VVPHGQSFQE-DYAGIFHFQIWQFGEWVDVVVDDRLPTKD-GELVFVHSAECQEFWSALL EK---AYAKLNGSYEALSGGSTTEGFEDFTGGVAEMYDLK-K---PPRNIAQIICKALER GSLLGCSID--------------------------------------------------- IT-------SAF------------------------------------------------ -D--MEAVTFKKLVKGHAYSVTGFK-----N-------VDY----RG---QQESLIRIRN PWG-QVEWTGAWSDS-----------SSEWNEVDPDQRE-ELHLK-MEDGEFWMSFREF- MRQFSRLEICN--LTPDALDK-DG------LS-RWHTTLFEGTWRRGST-------AGGC RNH-P-----------ATFWINPQFKIKLLEEDD---DPE----DDE------------- ---------VACTFLVALMQKHRRKARRVGEDMHTIGFAVYE---V-----P--E----E --AQGCQNVHLKKDFFLRNQSQARSETFINLREVSNHIRLPPGEYIIVPSTFEPNKEAD- -FVLRVFTEKQS------DAE--E---LDEEISADLPD---------------------- -------------------------------E--E-EI---SE-DDVDE-NFKN---MFR QLA-GE---------------------------------------------DMEISVFEL RTV-------------LNRVI-AR------------------------------------ -------------H---------------------------KDL------KTDGFS-MDS CRNMVNLM-D---KDGSARLGLVEFQILWNKIRSWL--------------------NIFR QHDLDKSGTMSAYEMRLALE---------------------------------------- ------TA----GFKLDNKLHQVLVARYADD-SLGVDFDNFVSCLVKLETMFRFFQSMDP EGT--GSAVMNLG--E-WLT-FT--MCG >T_guttata_ENSTGUP00000008345 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------MMPFGGMAA------------RVERDRL- -----RAEGLGEHNNAIKYLN-QDYEALKQQCIESGTLFRDPQFPAGPSALGFKELGPHS SKTRGVEWKRPSELVDDPQFIVGGATRTDICQ--GAL--GDCWLLAAIGSLTLNEELLHR VVPHGQSFQE-DYAGIFHFQIWQFGEWVDVVVDDQLPTKD-GELLFVHSAECTEFWSAVL EK---AYAKLNGCYESLSGGSTTEGFEDFTGGVAEMYDLK-R---PPRNMGHIIRKALER GSLLGCSID--------------------------------------------------- IT-------SAF------------------------------------------------ -D--MEAVTFKKLVKGHAYSVTAFR-----D-------VNY----RG---QQEQLIRIRN PWG-QVEWTGAWSDG-----------SAEWNNIDPDERE-ELQLK-MEDGEFWMSFRDF- MREFSRLEICN--LTPDALTK-DE------LS-RWHTQVFEGTWRRGST-------AGGC RNH-P-----------ATFWINPQFKIKLLEEDD---DPG----DDE------------- ---------VACSFLVALMQKHRRRERRVGGDMHTIGFAVYE---V-----P--E----E --AQGMQNVHLKKDFFLRNQSRARSETFINLREVSNQIRLPPGEYIIVPSTFEPHKEAD- -FVLRREREKQA------RGG--C---LKEQRRASFPV---------------------- -------------------------------G--E-EI---TE-DDIED-SFKN---MFQ QLA-GE---------------------------------------------DMEISVFEL RTI-------------LNRVI-SR------------------------------------ -------------H---------------------------KDL------KTDGFS-LDS CRNMVNLM-D---KDGSARLGLVEFQILWNKIRSWL--------------------TIFR QYDLDKSGTMSSYEMRMALE---------------------------------------- ------SA----GFKLNNKLHQVVVARYADN-DMGVDFDNFVCCLLKLETMFRFFRSMDP EGT--GTAVMNLS--E-WLL-LT--MCG >G_aculeatus_ENSGACP00000026409 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------MRLLLNGKIIK------------STKHRRD- -----KDRGIGSFGRALKYLN-QDYEVLRRRCSESGRLFQDETFPAHGSSLGFRELGPGS PKTRGVSWERPTELTSDPEFIVSGASRTDICQ--GAL--GDCWLLAAIASLTLNEEVLAR VVPHGQSFRKGEYAGIFHFQFWQFGEWVDVVIDDRLPVKD-GELMFVHSAEGREFWSALL EK---AYAKMNGCYEALSGGSTTEGFEDFTGGIAEVHDLN-R---PDPHLFHIIHMGQNR GSLMGCSID--------------------------------------------------- IT-------SSS------------------------------------------------ -D--SEAVTSQKLVKGHAYSVTGTA-----Q-------VEY----RG---NMEKLIRIRN PWG-QVEWTGAWSDDSI---------SAQWRQISDEDRE-RLSHR-SEDGEFWMSFNDF- LRHYSRLEICN--LTPDALSD-DS------VS-RWALSKFDGSWRRGST-------AGGC RNF-P-----------NTFWTNPQFVIRLDEEDD---DPD----DGE------------- ---------SGCSFVVGLIQKNRRSMRKMGEDMHTVGFAIYE---V-----P--E----E --FCGQRNVHLNRNFFLSNASAARSETFINLREVCSRFCLPPGEYLIVPSTFEANKDGD- -FCVRVFSEKQVLCKSILNSQ--E---LDDPIESRVE----------------------- -------------------------------K--I-EI---DE-GDVDD-RFRS---LFG QLA-GE---------------------------------------------DCEISTHEL QRI-------------LNKVV-TR------------------------------------ -------------R---------------------------SDI------ETDGFS-IST CRNMINML-D---KDGSGKLGLLEFKVLWTKIENYL--------------------KIYR QKDVDNSGTMSSSEMRTAVE---------------------------------------- ------EA----GFSLNNPLHQVLVARYSDP-DLTIDFDNFVSCLVRLETMFNTFNVLDK DNS--GTVEFNMM--E-WLN-AS--LL- >G_gallus_ENSGALP00000016538 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------MMPFGGIAA------------RLQRDRL- -----RAEGVGEHNNAVKYLN-QDYEALKQECIESGTLFRDPQFPAGPTALGFKELGPYS SKTRGVEWKRPSELVDDPQFIVGGATRTDICQ--GAL--GDCWLLAAIGSLTLNEELLHR VVPHGQSFQE-DYAGIFHFQIWQFGEWVDVVVDDLLPTKD-GELLFVHSAECTEFWSALL EK---AYAKLNGCYESLSGGSTTEGFEDFTGGVAEMYDLK-R---APRNMGHIIRKALER GSLLGCSID--------------------------------------------------- IT-------SAF------------------------------------------------ -D--MEAVTFKKLVKGHAYSVTAFK-----D-------VNY----RG---QQEQLIRIRN PWG-QVEWTGAWSDG-----------SSEWDNIDPSDRE-ELQLK-MEDGEFWMSFRDF- MREFSRLEICN--LTPDALTK-DE------LS-RWHTQVFEGTWRRGST-------AGGC RNN-P-----------ATFWINPQFKIKLLEEDD---DPG----DDE------------- ---------VACSFLVALMQKHRRRERRVGGDMHTIGFAVYE---V-----P--E----E --AQGSQNVHLKKDFFLRNQSRARSETFINLREVSNQIRLPPGEYIVVPSTFEPHKEAD- -FILRVFTEKQS------DTA--E---LDEEISADLAD---------------------- -------------------------------E--E-EI---TE-DDIED-GFKN---MFQ QLA-GE---------------------------------------------DMEISVFEL KTI-------------LNRVI-AR------------------------------------ -------------H---------------------------KDL------KTDGFS-LDS CRNMVNLM-D---KDGSARLGLVEFQILWNKIRSWL--------------------TIFR QYDLDKSGTMSSYEMRMALE---------------------------------------- ------SA----GFKLNNKLHQVVVARYADA-ETGVDFDNFVCCLVKLETMFRFFHSMDR DGT--GTAVMNLA--E-WLL-LT--MCG >G_aculeatus_ENSGACP00000006306 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------EVKMTSTAE------------RLARQKE- -----RAEGIGTNQQAVKFSQ-QDYETLRQECLKRGRLFEDDCFPAEPKSLGFNELGPYS SKTRGVVWKRPTDLCSEPQFIKDGATTTDICQ--GAL--GDCWLLAAIASLTLDQRILAR VVPPGQSFSD-DYAGIFHFQFWQFGEWVDVVVDDRLPTKD-GELLFVHSAEGSEFWSALL EK---AYAKINGCYEALSGGSTTEGFEDFTGGIAERHELK-N---ADPRLFKIIKKALER GSLLGCSID--------------------------------------------------- IT-------SAS------------------------------------------------ -D--SEAVTYRKLVKGHAYSVTGAE-----Q-------VDY----RG---DQVQLIRIRN PWG-QVEWNGAWSDR-----------SSEWRYVSDGDRK-RLTNR-CEDGEFWMSFSDF- LRQYSRLEICN--LTPDALTG-DE------FK-KWAESEFEETWRRGVS-------AGGC RNF-P-----------DSFWMNPQFVIKLEEVDD---DPE----DGE------------- ---------EGCTFIVGLMQKNRRRMRKMGQDMETIGFAIYE---L-----P--D----E --YSGQRQVHLKRNFFVRNCSAARSETFINLREVSNHFCLPPGEYLIVPSTFEPNKNGD- -FYVRVFSEKQT------AFQ--E---IDDPVACHVE----------------------- -------------------------------K--I-DI---DE-DDISD-RFKR---LFG QLA-GH---------------------------------------------DVEISAFEL QKI-------------LNRVV-VK------------------------------------ -------------R---------------------------EDI------KTSGFS-LTT CHHMVNLL-D---KDGSGKLGLVEFKILWTKIEKFL--------------------DVYK EKDANQSGCMNSSEMRMAVE---------------------------------------- ------EI----GFSLNTALHQIILARYSEE-DLTIDFDSFVCSMIRLESLFNIFNTLEK NGS--GEIELGFM--E-QPF-PP--LCG >G_gallus_ENSGALP00000015272 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PAPYTSSSPTDRGSMAGLAA------------RLCQERA- -----AAEGLGSYRKAISYLG-QDYEALRQRCLQTGTLFKDEEFPACPSALGYQDLGPYS FKTQGVVWKRPTELCDNPQFIVGGATRTDVCQ--GEL--GDCWLLAAIASLTLNPDVLHQ VVPKAQSFQE-NYAGIFHFQFWQYGEWVDVVVDDRLPTKN-GELLFVHSEEGNEFWSALL EK---AYAKLNGSYEALAGGSTIEGFEDFTGGISESYDLR-R---APANLFQIVQKALRA GSLLGCSID--------------------------------------------------- IT-------RAS------------------------------------------------ -E--TEAITSLKLVKGHAYSVTGAE-----E-------VYY----RG---RPEKLVRLRN PWG-EIEWTGAWSDN-----------APEWNYIDPKQKQ-ALDKQ-VDDGEFWMAFSDF- QRQFTRLEICN--LTPDTLTS-NQ------VN-KWDLTMFNGQWIRGST-------AGGC QNY-P-----------ATYWINPQFKIRLDEPDD---DHEGS--LNE------------- ---------PCCTILVGLMQKNRRRQKRMGEGLLSIGYSLYQ---I-----P--Q----E --LENNKDIHLNRAFFTRNQPVARSETYINLREVSSRIKLPKGEYLIVPSTFEPYKNGE- -FCLRVFSEKKV------KTQ--M---IGDTVAAKPY----------------------- -------------------------------E--P-HV---DN-KDIDE-EFKT---LFQ KLS-GE---------------------------------------------DCEVTATEL QTI-------------LNRVL-VK------------------------------------ -------------R---------------------------KDI------RSDGFN-INT CREMISLL-D---TNGTGTLGLIEFKTLWMKIQMYL--------------------AIYR KVDRDYSGTIDSHEMRNALS---------------------------------------- ------EA----GFVLNNQVQQSIAIRYACS-KMTIDFDGFVACMIRLETLFKVFHLLDK EKS--GVVRLSLA--E-WLC-CT--LV- >T_rubripes_ENSTRUP00000032319 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------FYFIIMSGVAS------------TLAKKRA- -----LAAGFGTNANAVPYLN-QNFAALRAECLSARKLFCDPAFPAAPEALGFKELGRSS YKVRGVTWKRPAELVSNPEFIMGGATRTDICQ--GAL--GDCWLLAAIASLTLNEYVMAR VVPSDQGFGD-DYAGIFHFQFWQFGEWVDVVIDDRLPVKD-NELMFVHSAEGREFWSALL EK---AYAKVNGCYEALSGGSTTEGFEDFTGGIAENYDLR-Q---PPSNLFQIVKKALEA GALLGCSID--------------------------------------------------- IT-------SAA------------------------------------------------ -D--SEAVTRQKLVKGHAYSLTGAV-----E-------VNY----RG---RQEKLVRMRN PWG-QVEWTGAWSDG-----------SSEWNYMQGDCPH----AN-AEDGEFWMSFSDF- LRHYSRIEVCT--LTPDTILD-DS------VK-HWSVSKFDGTWRKGST-------AGGC RNH-P-----------YTFWMNPQFVINLQEEDD---DPD----DGE------------- ---------EGCSFVVGLIQKNRRKLRKQGEDMHTIGFAIYE---V-----P--E----Q --FKGQREVHLDKNFFLSHAQTARSETFINLREVCSRFKLPPGEYLIVPSTFEPHQNGD- -FCIRVFSEKQT------DTQ--P---CDDPINADLDDVTVQ------------------ -------------------------------E----TV---SD-EDVDA-GFRG---LFT KLA-GNVMTQWRS--------------------------------------DMEISAVEL QTI-------------MNKIV-GK------------------------------------ -------------R---------------------------SDI------KTNGFS-MET CRVMVNLM-D---DSGNGKLGLGEFATLWKKIQRYL--------------------SIYK KNDIDNSGTMSTPEMRVAFK---------------------------------------- ------DA----GFTLNNTIYQLLVARYSDP-NMTIDFDNFVGCLMRLEMMFRIFKKLDV QNS--GLIELNFQ--Q-WVN-FS--MV- >T_nigroviridis_ENSTNIP00000007724 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------APGAAEPPADAAAEAQTPPSGGWRPERCMSGVAS------------TLAKKRA- -----LAAGFGTNANAVPYLN-QNFAALRAQCLSAGRLFCDPAFPAAPESLGFQELGRSS YKVRGVTWKRPSELVSKPEFIVGGATRTDICQ--GAL--GDCWLLAAIASLTLNEFVLAR VVPGDQGFGE-DYAGIFHFQFWQFGEWVDVVIDDRLPVKD-DELMFVHSAEGREFWSALL EK---AYAKVNGCYEALSGGSTTEGFEDFTGGIAENYDLR-K---PPSNLFQILKKALEA GALLGCSID--------------------------------------------------- IT-------SAA------------------------------------------------ -D--SEAVTGQKLVKGHAYSLTGAV-----E-------VTY----LG---RQEKLVRMRN PWG-QVEWTGAWSDG-----------SSEWDNVQGDCPH----AN-AEDGEFWMSFNDF- CRHYSRIEVCT--LTPDTILD-DS------VK-HWSVSKFDGTWRRGST-------AGGC RNH-P-----------YTFWTNPQFVISLQE--D---EED----DGE------------- ---------DGCSFVVGLIQKNRRKLRKQGEDMHTIGFAIYE---V-----P--E----Q --FKGQREVHLDKNFFLSHAQKARSETFINLREVCSRFKLPPGEYLIIPSTFEPHLNGD- -FCIRVFSEKQA------DTQ--P---CDDPVSANLED---------------------- -------------------------------E----TV---AD-QDVDP-GFRG---LFS KLA-GP---------------------------------------------DMEISAPEL QKI-------------LNKIV-GK------------------------------------ -------------R---------------------------SDI------KTDGFS-MDT CRVMVNLM-D---DSGNGKLGLGEFATLWKKIQRYL--------------------SIYK KNDTDGSGTMSTPEMRVAFK---------------------------------------- ------DA----GFTLNNSIYQLLVARYSEP-DMTIDF-NFVGCLMRLEMMFKIFKKLDV EDS--GSIELNFQ--Q-WLE-FS--MI- >D_rerio_ENSDARP00000069135 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------MFSYGGISA------------HISANRL- -----KADGAGSFEQALHFQN-QDYEALRQECLEGGYLFEDPCFPAEPPSLGFKELAPHS SKTRDVEWMRPTELCDDPQFIVGGATRTDICQ--GAL--GDCWLLAAIGSLTLNERLLHR VVPHGQSFQD-DYAGIFHFQFWQFGEWVDVVIDDRLPVKD-GELMFVHSAEGNEFWSALV EK---AYAKLNGSYEALSGGSTTEGFEDFTGGVSEMYELR-K---APRDLYRIISKALDR GSLLGCSID--------------------------------------------------- IT-------SAF------------------------------------------------ -D--MESVTFKKLVKGHAYSVTALK-----Q-------VEY----RG---RMERLIRIRN PWG-QVEWTGAWSDN-----------SPEWDEIDPSEKD-DLHLQ-MEDGEFWMSFGEF- LRQFSRLEICN--LTPDALSD-DD------MS-HWNTIKFHGAWRRGST-------AGGC RNH-P-----------NTFWINPQYKITLLEEDD---DPE----DEE------------- ---------VACSFLVALMQKDRRRYRRHGQDMHTIGFAIYE---V-----P--E----E --YTGCQNVHLKKDFFLSNSSAARSETFINLREVSTRLRLPPGEYIIVPSTFEPSKEAD- -FVLRVFTEKQS------ETE--E---LDDEISADLED---------------------- -------------------------------E--E-EI---TE-DDIDD-SFKS---LFA QLA-GE---------------------------------------------DMEISVHEL KTI-------------LNRVV-SK------------------------------------ -------------H---------------------------KDV------KTDGFS-MDS CRTMVNLL-D---KDGSARLGLVEFQILWNKIRKLL--------------------GIFR EFDIDKSGTMSSYEMRLAVE---------------------------------------- ------SA----GFKLNNRLNQILVARYAEN-EA-IDFDNFVCCLIKLEAMFRSFQQLDR EET--GTAEMNLS--E-WLF-MT--MCG >G_aculeatus_ENSGACP00000026396 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MSGVAS------------TLAKRRA- -----VAAGFGTNANASRYLN-QDFASLRAQCRSAGKLFCDVTFPAEPEALGFKELGRGS SKVRGVTWKRPTELVSNPEFILGGATRTDICQ--GAL--GDCWLLAAIASLTLNEYVMAR VVPTDQGFGD-NYAGIFHFQFWQFGEWVDVVIDDRLPVKD-GELLFVHSAEGREFWSALL EK---AYAKVNGCYEALSGGSTTEGFEDFTGGIAENFDLQ-R---PPPNLFYIIKKALEA GALLGCSID--------------------------------------------------- IT-------SAA------------------------------------------------ -D--SEAVTRQKLVKGHAYSLTGAV-----E-------VNY----RG---RQEKLVRVRN PWG-QVEWTGAWSDG-----------SSEWNYVEGDCPH----AK-AEDGEFWMSFSEF- SRNYNRVEVCT--LTPDAIDD-DS------VK-HWSVSKFDGTWRRGST-------AGGC RNH-P-----------YTFWTNPQFVVRLEEEDD---DPD----DGD------------- ---------VGCSFVVGLIQKNRRKLRQQGEDMHTVGFAIYE---V-----P--K----Q --FYGQREVHLDKNFFLTHAQTAKSETFINLREVSTRFKLPPGEYLVVPSTFEPHLNGD- -FCIRVFSEKQT------ETL--P---CDDPVSAELED---------------------- -------------------------------E----TV---SD-EGVDA-GFRG---LFT KLA-GD---------------------------------------------DMEISAGEL RTI-------------LNKIV-AK------------------------------------ ----------PLRR---------------------------TDI------KTDGFS-MET SRIMVNLM-D---DSGNGKLGLGEFATLWKKVQRYL--------------------TIYK KNDADNSGTMSTPEMRVAFK---------------------------------------- ------DA----GFTLNNNIYQLLVARYSDP-DMTIDFDNFVGCLMRLEMMFKIFKRLDP HDS--GSIELDFN--SDYIC-IH--IL- >D_rerio_ENSDARP00000095871 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------YSMFSIGGVST------------RIYKERL- -----QAEGMGANDLAIKFLN-QDYEELRRECVESGRLFEDPCFPAVPQSLGFKELAPNS SKTRGVKWIRPTELSENPQFIVGGATRTDICQ--GAL--GDCWLLAAIASLTLNDKLLHR VVPHGQSFTN-EYAGIFHFQFWQFGEWVDIVIDDRLPVKD-KELMFVHSAEGNEFWSALL EK---AYAKLNGSYEALSGGSTTEGFEDFTGGVAEMYELR-S---APKDLHRIIAKALER GSLLGCSID--------------------------------------------------- IT-------SAF------------------------------------------------ -D--MEAVTFKKLVKGHAYSVTALR-----E-------VNF----RG---NRERLIRIRN PWG-QVEWTGAWSDN-----------SSEWNGIDPSERE-ELNNH-MEDGEFWMSFQEF- KRQFSRLEICN--LTPDALSD-DS------QH-FWNTIQFNGTWRKGST-------AGGC RNN-P-----------NTFWINPQYKITLLEEDD---DPE----DNE------------- ---------VACTFMVALMQKDRRRFRKQGQDMHTIGFALYE---V-----P--D----E --FLGSQNVHLKKDFFLRHSSCARSETFINLREVSTRLRLPPGEYLIVPSTFEPGKEAD- -FVLRVFTEKQS------ETQ--E---MDDEISFNLED---------------------- -------------------------------E--E-AV---SE-ENIDA-SFKK---MFA QLS-GE---------------------------------------------DMEISVHEL RTI-------------LNRVM-TK------------------------------------ -------------H---------------------------RDL------KTDGFS-LES CRCMINLM-D---KDGSARLGIVEFQILWNKIRKWL--------------------GVFR QFDLDKSGTMSSYEMRLAVE---------------------------------------- ------SA----GFKLNNKLHQILVARYSDG-DV-IDFDNFVCCLVKLEAMFKSFKELEK EGS--GVAELNIS--E-WLY-LT--MCG >O_latipes_ENSORLP00000014711 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------FLSCTSMYPAGGISA------------AIYNDRL- -----RSEGMGSKDHAVLFAN-QDFESLKRDCLESGCLFEDPCFPAEPPSLGFKELAPHS SKTRGVEWIRPTELTSEPQFIVGGATRTDICQ--GALATGDCWLLAAIASLTLNERLLHR VVPHGQSFQE-DYAGIFHFQFWQFGEWVDVVIDDRLPVKD-GELMFVHSAEGNEFWSALM EK---AYAKLNGSYEALSGGSTTEGFEDFTGGVSEMYELR-K---APRDLHRIISKALER GSLLGCSID--------------------------------------------------- IT-------SAF------------------------------------------------ -D--MEAVTFKKLVKGHAYSVTGLK-----E-------VDY----RG---NMVRLIRIRN PWG-QVEWTGAWSDN-----------SHEWNDVDPSDRE-DLHLK-MEDGEFWMSFSDF- LRQFSRLEICN--LTPDALSE-DA------LS-HWNTMKFYGTWRRGST-------AGGC RNH-P-----------NTFWINPQYKITLLEEDD---DPE----DDE------------- ---------VACSFLVALMQKDRRRYRRHGQDMHTIGFALYE---I-----P--E----E --YRGCHNVHLKKNFFLSHSSCARSETFINLREVSARLRLPPGEYLVVPSTFEPSKEAD- -FVLRVFTEKQS------ETE--E---LDDEISADFGD---------------------- -------------------------------EKQD-EI---TE-DDIDD-SFRS---MFA QLA-GE---------------------------------------------DMEISIREL KTI-------------LNRVI-SR------------------------------------ -------------H---------------------------KDL------KTDGFS-SES CRTMVNLM-D---KDGSARLGLLEFQILWNKIRKWL--------------------GIFR EFDLDKSGAMSSYEMRLAVE---------------------------------------- ------GA----GFKLNNQLNQILVARYADN-EM-VDFDNFICCLVKLEAMFKYFQELDK DGS--GVVEMNLT--E-WLY-LT--MCG >T_guttata_ENSTGUP00000002717 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------GSMSRVTA------------RLCQERA- -----AADGLGSNRNAIKYLK-QDYEALKQQCLQNGTLFKDEEFPACPSALGYQDLGPYS FKTRGIIWKRPTELCANPQFIIGGATRTDVCQ--GEL--GDCWLLAAIASLTLNPDILFR VVPKAQSFQE-DYAGIFHFQFWQYGEWVDVVVDDRLPTKN-GKLLFVHSEEGNEFWSALL EK---AYAKLNGSYEALAGGSTVEGFEDFTGGISESYELR-R---APSNLYQIIQKALRA GSLLGCSID--------------------------------------------------- IT-------AAA------------------------------------------------ -E--IEAITSLKLVKGHAYSITGAE-----E-------VYY----RG---RPEKLVRLRN PWG-EVEWTGSWSDN-----------APEWNYVDPKQKQ-ALDKQ-VDDGEFWMAFSDF- QRQFSRLEICN--LTPDTLTS-NK------VH-KWDLTLFNGQWRRGSS-------AGGC QNY-Q-----------ATYWTNPQFKIQLDEPDD---DHEGS--LNE------------- ---------PCCTILVGLMQKNRRRQKRMGEGLLSIGYSLYQ---I-----P--Q----E --LESSPDVHAGRAFFAKHQPAARTDSYVNLREVSSRMTLPRGQYLIVPSTFEPYKNGE- -FCLRVFAEKQA------KSQ--M---TGDEVSAKPY----------------------- -------------------------------E--P-HV---DN-KDIDD-EFKT---LFQ KLS-GE---------------------------------------------DCEVTATEL QRI-------------LNRVL-AK------------------------------------ -------------R---------------------------KDV------KSDGFN-INT CREMISLL-D---TDGTGTLGLVEFKTLWMKIQKYL--------------------AIYK KVDSDYSGTIDSHEMRNALR---------------------------------------- ------EA----GECAAQGLQHSIVTRYACSTRLTIDFDGFVACMIRLETLFKVFQLLDK DKN--GVIQISLP--E-WLC-CT--LV- >A_carolinensis_ENSACAP00000003082 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MTSLAI------------KLAKERE- -----VLEGLGSNGKAIKYLK-QDFEELRRQCLKSGTLFKDEEFPACPSALGYRDLGPYS PKTQGIIWKRPSELVPNPQFIVGGATRTDIRQ--GAL--GDCWLLAAIASLTLDQEILDR VVPKDQSFQK-DYAGIFHFQIWQYGEWVDVVVDDRLPTKN-GQLLFLHSEEGNEFWSALL EK---AYAKLNGSYEALTGGSTIEGFEDFTGGIAESYDLR-K---APSNLYQIIQKALRS GSLLGCSID--------------------------------------------------- IA-------SAA------------------------------------------------ -E--TEAITRLKLVKGHAYSVTGAE-----E-------VNY----RG---QPVKLLRIRN PWG-EVEWTGAWSDN-----------APEWNYIDPKEKN-ALDKQ-ADDGEFWMSLADF- QRQFTRLEICN--LTPDTLTS-NH------LH-KWGMTLFNGHWRRGCT-------AGGC QNY-P-----------ATYWTNPQFKISLDEPDD---DHEGS--ASE------------- ---------PSCTVLIGLMQKNRRRQKRMGEALLSIGYSIYQ---V-----Y--D----F --LENQTDVHLNRDFFSTNRSVARSDTYVNLREVSNRFHLPRGEYLVVPSTFEPFKDGE- -FCLRVFSEKKA------KAQ--Y---VSSTKNSSFH----------------------- -------------------------------G--V-SA---TC-KDVDN-EFKN---LFE KLS-GE---------------------------------------------DCEMTANEL QTI-------------LNRVI-TK------------------------------------ -------------R---------------------------TDI------KSDGFN-LNT CREMISLL-D---NHGTGSLGVAEFKILWMKIQRYL--------------------EIYK KVDTDHSGTIDAHEMRDALK---------------------------------------- ------EA----GFTLNNKVQHTIAARYACS-KLTIDFDGFLACMIRLETLFKMFQMLDK EKR--GTVQLSLA--------------- >G_aculeatus_ENSGACP00000006578 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------LHRALIITMYPTGGISS------------AIQANRL- -----RADGMGSKEQAVLFSN-QDYETLKQECLESGCLFEDSCFPAEPPSLGFKELAPYS SKTKDVVWMRPSELNDDPQFIVGGATRTDICQ--GAL--GDCWLLAAIGSLTLNERLLHR VVPHGQSFQD-DYAGIFHFQFWQFGDWVDVVIDDRLPVKD-GELMFVHSAEGNEYWSALL EK---AYAKLSGSYEALSGGSTTEGFEDFTGGVSEMYELR-S---APRDLHRIIGKALER DSLLGCSID--------------------------------------------------- IT-------SAF------------------------------------------------ -D--MEAVTFKKLVKGHAYSVTGMK-----E-------VHF----RG---NMERLIRIRN PWG-QVEWTGAWSDN-----------SPEWNEIDPSERE-DLHLK-MEDGEFWMSFSEF- KRQFSRLEICN--LTPDTLSE-DS------LG-KWHTMKFYGAWRRGST-------AGGC RNS-P-----------NTFWINPQYKITLLEEDD---DPE----DDE------------- ---------VACSFLVALMQKDRRRYRRHGQDMHTIGFALYE---I-----P--E----E --YRGCQNVHLKKNFFLSHSSCARSETFINLREVSTRLRLPPGEYLIVPSTFEPSQEAD- -FVLRVFTEKQS------ETE--E---LDDEISADLGD---------------------- -------------------------------D--D-VI---TE-DDIDD-SFKS---MFA QLA-GE---------------------------------------------DMEISVREL RTI-------------LNRVV-CR------------------------------------ -------------H---------------------------KDL------KTDGFS-VES CRTMVNLM-D---KDGSARLGLVEFQILWNKIRKWL--------------------VIFR DFDLDKSGAMSSYEMRLAVE---------------------------------------- ------AA----GFKLNNRLNQILVARYAEN-EM-VDFDNFICCLVKLEAMFRSFQQFDK EGS--GEAEMNVT--E-WLY-LT--MCG >X_tropicalis_ENSXETP00000040260 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GDCWLLAAIASLTLNEQILSR VVPKDQSFQE-NYAGIFHFQFWQYGEWVDVVIDDRLPTKD-GKLLFVHSAEGSEFWSALM EK---AYAKLNGSYEALSGGTTTEGFEDFTGGLAEWYELR-K---APPNLFKIIQKALRT GSLLGCSID--------------------------------------------------- IT-------SAA------------------------------------------------ -E--TEAITFQKLVKGHAYSVTAAE-----E-------VQY----RG---NLEKLIRIRN PWG-EVEWTGAWSDN-----------SSEWNSVDPDVRE-KLIKR-CDDGEFWMSFNDF- LRNYSRLEICN--LTPDTLAS-DK------YS-KWSLTKMDGTWRRGST-------AGGC RNF-P-----------ETFWMNPQYVIKLEEADD---DPD----DNE------------- ---------EGCTFIVGLIQKNRRKQRKMGEDMHTIGFAIYE---V-----P--P----Q --LTGQKDIRLSRDYILRNKIREKSDTYINLREVLNRFRLPPGEYVILPSTFEPHKVGD- -FCLRVFSEKNA------ESK--V---PDDEIKADID----------------------- -------------------------------E----DV---NE-DAIDP-NFKR---MFL ALA-GD---------------------------------------------DKEISPHEL FNI-------------LQKVI-SK------------------------------------ -------------R---------------------------EDI------KSDGFS-IET CRTIVDLL-D---SDGTGKLGLKEFKILWTKILKYQ--------------------KIYS SVDRDHSGTINSYEMRGALE---------------------------------------- ------AA----GIKVNSTINELLVARFADE-DHTIDFDNFVRCLLRLEIMFKIFNQMDT EKT--GVVTLKMD--T-WLS-LT--VI- >P_pygmaeus_ENSPPYP00000003556 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------MSEEIITPV-YCTGVSA------------QVQKQRA- -----RELGLGRHENAIKYLG-QDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNS SKTYGIKWKRPTELLSNPQFIVDGATRTDICQ--GAL--GDCWLLAAIASLTLNDTLLHR VVPHGQSFQN-GYAGIFHFQLWQFGEWVDVVVDDLLPIKD-GKLVFVHSAEGNEFWSALL EK---AYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELR-K---APSDLYQIILKALER GSLLGCSID--------------------------------------------------- IS-------SVL------------------------------------------------ -D--MEAITFKKLVKGHAYSVTGAK-----Q-------VNY----RG---QMVSLIRMRN PWG-EVEWTGAWSDS-----------SSEWNNVDPYERD-QLRVK-MEDGEFWMSFRDF- MREFTRLEICN--LTPDALKS-RT------IR-KWNTTLYEGTWRRGST-------AGGC RNY-P-----------ATFWVNPQFKIRLDETDD---PDDYG--DRE------------- ---------SGCSFVLALMQKHRRRERRFGRDMETIGFAVYE---V-----S--H----Q --LAGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGD- -FVLRFFSEKSA------GTA--E---LDDQIQANLPD---------------------- -------------------------------E--Q-VL---SE-EEIDE-NFKA---LFR QLA-GE---------------------------------------------DMEISVKEL RTI-------------LNRII-SK------------------------------------ -------------H---------------------------KDL------RTKGFS-LES CRSMVNLM-D---RDGNGKLGLVEFNILWNRIRNYL--------------------SIFR KFDLDKSGSMSAYEMRMAIE---------------------------------------- ------SA----GFKLNKKLYELIITRYSEP-DLAVDFDNFVCCLVRLETMFRFFKTLDT DLD--GVVTFDLF--K-WLQ-LT--MFA >P_troglodytes_ENSPTRP00000006670 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------MSEEIITPV-YCTGVSA------------QVQKQRA- -----RELGLGRHENAIKYLG-QDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNS SKTYGIKWKRPTELLSNPQFIVDGATRTDICQ--GAL--GDCWLLAAIASLTLNDTLLHR VVPHGQSFQN-GYAGIFHFQLWQFGEWVDVVVDDLLPIKD-GKLVFVHSAEGNEFWSALL EK---AYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELR-K---APSDLYQIILKALER GSLLGCSID--------------------------------------------------- IS-------SVL------------------------------------------------ -D--MEAITFKKLVKGHAYSVTGAK-----Q-------VNY----RG---QMVSLIRMRN PWG-EVEWTGAWSDS-----------SSEWNNVDPYERD-QLRVK-MEDGEFWMSFRDF- MREFTRLEICN--LTPDALKS-RT------IR-KWNTTLYEGTWRRGST-------AGGC RNY-P-----------ATFWVNPQFKIRLDETDD---PDDYG--DRE------------- ---------SGCSFVLALMQKHRRRERRFGRDMETIGFAVYE---V-----S--H----Q --LVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGD- -FVLRFFSEKSA------GTA--E---LDDQIQANLPD---------------------- -------------------------------E--Q-VL---SE-EEIDE-NFKA---LFR QLA-GE---------------------------------------------DMEISVKEL RTI-------------LNRII-SK------------------------------------ -------------H---------------------------KDL------RTKGFS-LES CRSMVNLM-D---RDGNGKLGLVEFNILWNRIRNYL--------------------SIFR KFDLDKSGSMSAYEMRMAIE---------------------------------------- ------SA----GFKLNKKLYELIITRYSEP-DLAVDFDNFVCCLVRLETMFRFFKTLDT DLD--GVVTFDLF--K-WLQ-LT--MFA >H_sapiens_ENSP00000279247 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------MSEEIITPV-YCTGVSA------------QVQKQRA- -----RELGLGRHENAIKYLG-QDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNS SKTYGIKWKRPTELLSNPQFIVDGATRTDICQ--GAL--GDCWLLAAIASLTLNDTLLHR VVPHGQSFQN-GYAGIFHFQLWQFGEWVDVVVDDLLPIKD-GKLVFVHSAEGNEFWSALL EK---AYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELR-K---APSDLYQIILKALER GSLLGCSID--------------------------------------------------- IS-------SVL------------------------------------------------ -D--MEAITFKKLVKGHAYSVTGAK-----Q-------VNY----RG---QVVSLIRMRN PWG-EVEWTGAWSDS-----------SSEWNNVDPYERD-QLRVK-MEDGEFWMSFRDF- MREFTRLEICN--LTPDALKS-RT------IR-KWNTTLYEGTWRRGST-------AGGC RNY-P-----------ATFWVNPQFKIRLDETDD---PDDYG--DRE------------- ---------SGCSFVLALMQKHRRRERRFGRDMETIGFAVYE---V-----S--H----Q --LVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGD- -FVLRFFSEKSA------GTV--E---LDDQIQANLPD---------------------- -------------------------------E--Q-VL---SE-EEIDE-NFKA---LFR QLA-GE---------------------------------------------DMEISVKEL RTI-------------LNRII-SK------------------------------------ -------------H---------------------------KDL------RTKGFS-LES CRSMVNLM-D---RDGNGKLGLVEFNILWNRIRNYL--------------------SIFR KFDLDKSGSMSAYEMRMAIE---------------------------------------- ------SA----GFKLNKKLYELIITRYSEP-DLAVDFDNFVCCLVRLETMFRFFKTLDT DLD--GVVTFDLF--K-WLQ-LT--MFA >D_rerio_ENSDARP00000072574 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MSNIAK------------VLSRRQD- -----RGEGLGTNEKAIPYNK-QDYQSLKQECLAKRALFCDPTFPAESDSLGYNELGRYS FKTKGVQWKRPKELCSNPEFIMDGANRTDICQ--GAL--GDCWLLAAIASLTLDKEILER VVPSGQSFTE-DYAGIFHFQFWQYGEWVDVVIDDRLPTRD-GKLLFVHSAEGSEFWSALL EK---AYAKVNGSYEALTGGSTTEGFEDFTGGITENYELS-K---APPNLFKLVQKALAL GSLLGCSID--------------------------------------------------- IT-------NSY------------------------------------------------ -E--TEAVTSLKLVKGHAYSVTAAE-----E-------VHF----RG---SLVQLVRIRN PWG-EVEWTGAWSDN-----------SKEWDSVRPEEKA-KLDYS-AEDGEFWMAYSDF- IQQFSKLEICN--LTPDTLSS-EE------VN-RWSYSQFEGNWRVGST-------AGGC RNN-P-----------ATFCSNPQFMIKLEEIDD---DPH----DGV------------- ---------NGCTFLVGLIQKDGRKDKRFGRDLNTIGFAIYK---V-----P--D----E --LKGRSNIHLGPDVLLRQRSVAGSNTFINLREVSERFKLPPGEYIIIPSTFEPHRKGS- -FILRVFAEKEA------DAS--Q---IGTEISADVK----------------------- -------------------------------K--H-FI---SE-KDIDP-HFKR---LFS QVA-GS---------------------------------------------DSEVSVLEL QQI-------------LNTVV-SK------------------------------------ ------------RR---------------------------SNV------KTDGFS-LET CRHIISLL-D---KDGSGKLGLLEFHTLWMKIQKYL--------------------EIFK HRDTDNSGTMSSLEMRDAVK---------------------------------------- ------EA----GFQLNNDVLEVLIARYANQ-EYAIDFDSFVSCLIRLELLFKMFQLFDK KNT--GKIELDIL--Q-WLC-LA--LS- >T_rubripes_ENSTRUP00000021242 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------MYSVGGISA------------SIYANRL- -----RAEGMGSNDRAVPFWN-QDYEALKQQCVESGCLFEDPCFPAEPPSLGFKELAPHS SKTQGVEWQRPTELTDDPQFIVGGATRTDICQ--GAL--GDCWLLAGIASLNLNERLLHR VVPHGQSFQD-DYAGIFHFQFWQFGEWVDVVIDDRLPVKD-GEVMFVHSAEGNEFWSALL EK---AYAKLNGSYEALSGGSTTEGFEDFTGGVSEMYELR-S---APRDLPKIISKALDR GSLLGCSIDKSYTCIQVGKIPNHFYLISLMTQHSIFISKQ-------------------- IT-------SAF------------------------------------------------ -D--MEAVTFKKLVKGHAYSVTGLK-----E-------VNF----RG---RMERLIRVRN PWG-QVEWTGAWSDN-----------SSEWNEIDPSERE-DLHLK-MEDGEFWMSFNEF- KKQFSRIEICN--LTPDALSE-DA------LS-HWNTMTYSGMWRRGST-------AGGC RNH-P-----------NTFWINPQFKITLLEEDD---DPE----DDE------------- ---------VACTFLVALMQKDRRRYRRQGQDMHTIGFAVYE---I-----P--E----E --FKGCQNVHLKKNFFLNHSSCARSETFINLREVSTRLRLPPGEYLIVPSTFEPHKEAD- -FVLRVFTEKQS------ETE--E---MDDQISADLGD---------------------- -------------------------------E--D-EI---SE-EDIDD-SFKS---MFA QLA-GE---------------------------------------------DMEISVHEL KTI-------------LNRVV-TR------------------------------------ -------------H---------------------------KDL------KTDGFS-TVS CRTMVNLM-D---KDGTAHLGLVEFQILWNKIRKWL--------------------VIFR QFDLDKSGAMSSYEMRLAVE---------------------------------------- ------AA----GFKLNNKLNQILVARYAEN-DM-INFDNFICCLVKLEAMFRHFQQLDK EGS--GVAEINIT--E-WLY-VT--MCG >D_rerio_ENSDARP00000090559 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------SSMFSYGGISA------------HISANRL- -----KADGAGSFEQALHFQN-QDYEALRQECLEGGYLFEDPCFPAEPPSLGFKELAPHS SKTRDVEWMRPTELCDDPQFIVGGATRTDICQ--GAL--GDCWLLAAIGSLTLNERLLHR VVPHGQSFQD-DYAGIFHFQFWQFGEWVDVVIDDRLPVKD-GELMFVHSAEGNEFWSALV EK---AYAKLNGSYEALSGGSTTEGFEDFTGGVSEMYELR-K---APRDLYRIISKALDR GSLLGCSID--------------------------------------------------- IT-------SAF------------------------------------------------ -D--MESVTFKKLVKGHAYSVTALKQCKTAQ-------VEY----RG---RMERLIRIRN PWG-QVEWTGAWSDN-----------SPEWDEIDPSEKD-DLHLQ-MEDGEFWMSFGEF- LRQFSRLEICN--LTPDALSD-DD------MS-HWNTIKFHGAWRRGST-------AGGC RNH-P-----------NTFWINPQYKITLLEEDD---DPE----DEE------------- ---------VACSFLVALMQKDRRRYRRHGQDMHTIGFAIYE---V-----P--E----E --YTGCQNVHLKKDFFLSNSSAARSETFINLREVSTRLRLPPGEYIIVPSTFEPSKEAD- -FVLRVFTEKQS------ETE--E---LDDEISADLED---------------------- -------------------------------E--E-EI---TE-DDIDD-SFKS---LFA QLA-GEVNIYLYSFYFTK---------------------------------DMEISVHEL KTI-------------LNRVV-SK------------------------------------ -------------H---------------------------KDV------KTDGFS-MDS CRTMVNLL-D---KDGSARLGLVEFQILWNKIRKLL--------------------GIFR EFDIDKSGTMSSYEMRLAVE---------------------------------------- ------SA----GFKLNNRLNQILVARYAEN-EA-IDFDNFVCCLIKLEAMFRSFQQLDR EET--GTAEMNLS--E-VLW-LD--FFI >B_taurus_ENSBTAP00000013509 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------MAEEFITPV-YCTGVSA------------QVQKQRA- -----KELGLGRHENAIKYLG-QDYEQLRVHCLQRGALFRDEAFPPVPQSLGFKELGPNS SKTYGIKWKRPTELFSNPQFIVDGATRTDICQ--GAL--GDCWLLAAIASLTLNDTLLHR VVPHGQSFQD-GYAGIFHFQLWQFGEWVDVVVDDLLPTKD-GKLVFVHSAQGNEFWSALL EK---AYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELR-K---APSDLYNIILKALER GSLLGCSID--------------------------------------------------- IS-------SIL------------------------------------------------ -D--MEAVTFKKLVKGHAYSVTGAK-----Q-------VNY----QG---QMVNLIRMRN PWG-EVEWTGAWSDG-----------SSEWNAVDPYMRE-QLRVK-MEDGEFWMSFRDF- MREFTRLEICN--LTPDALKS-QR------FR-NWNTTLYEGTWRRGST-------AGGC RNY-P-----------ATFWVNPQFKIRLEETDD-PDPDDYG--GRE------------- ---------SGCSFLLALMQKHRRRERRFGRDMETIGFAVYE---V-----P--P----E --LMGQPAVHLKRDFFLSNASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGD- -FVLRFFSEKSA------GTQ--E---LDDQVQANLPD---------------------- -------------------------------E--Q-VL---SE-EEIDE-NFKS---LFR QLA-GE---------------------------------------------DMEISVKEL RTI-------------LNRII-SK------------------------------------ -------------H---------------------------KDL------RTTGFS-LES CRSMVNLM-D---RDGNGKLGLVEFNILWNRIRNYL--------------------SIFR KFDLDKSGSMSAYEMRMAIE---------------------------------------- ------FA----GFKLNKKLYELIITRYSEP-DLAVDFDNFVCCLVRLETMFRFFKTLDT DLD--GVVTFDLF--K-WLQ-LT--MFA >T_nigroviridis_ENSTNIP00000019733 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------FLSPSSMQPVGGISA------------RIYAERL- -----RAEGMGSNQQAVPFCS-QDYEALKQQCVESGCLFEDPLFLAQPASLGFKELAPHS SKTRGVEWQRPTELTGDPQFIVGGATRTDICQ--GAL--GDCWLLAAIASLTLNERLLHR VVPHGQSFQD-DYAGIFHFQFWQFGEWVDVVIDDRLPVKD-GELMFVHSAEGNEFWSALL EK---AYAKLNGSYEALSGGSTTEGFEDFTGGVSEMYELR-S---APRDLAKIISKALDR GSLLGCSID--------------------------------------------------- IT-------SAF------------------------------------------------ -D--MEAVTFKKLVKGHAYSVTGLK-----E-------VNF----RG---RMERLIRVRN PWG-QVEWTGAWSDN-----------SPEWNEIDPSERE-DLHLK-MEDGEFWMSFNEF- KKQFSRIEICN--LTPDALSE-EA------LS-HWNTMTYYGMWRRGST-------AGGC RNH-P-----------NTFWINPQFKITLLEEDD---DPE----DDE------------- ---------VACSFLVALMQKDRRRYRRQGQDMHTIGFAVYE---I-----P--E----E --FRGCQNVHLKKNFFLSHSSCARSETFINLREVSTRLRLPPGEYLVVPSTFEPNKEAD- -FVLRVFTEKQS------ETE--E---MDDQISADLGE---------------------- -------------------------------E--D-EI---TE-EDIDD-SFKS---MFA QLA-GE---------------------------------------------DMEISVHEL KTI-------------LNRVV-TR------------------------------------ -------------H---------------------------KDL------KTDGFS-TES CRTMVNLM-D---KDGSAHLGLVEFQILWNKIRKWL--------------------VVFR QFDLDKSGSMSSYEMRLAVE---------------------------------------- ------AA----GFKLNNKLNQILVARYAEN-DM-INFDNFICCLVKLEAMFRHFQQLDE DGS--GVVEMNIT--Q-WLY-LT--MCG >M_musculus_ENSMUSP00000025891 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------MTEELITPV-YCTGVSA------------QVQKKRD- -----KELGLGRHENAIKYLG-QDYETLRARCLQSGVLFQDEAFPPVSHSLGFKELGPHS SKTYGIKWKRPTELMSNPQFIVDGATRTDICQ--GAL--GDCWLLAAIASLTLNETILHR VVPYGQSFQD-GYAGIFHFQLWQFGEWVDVVIDDLLPTKD-GKLVFVHSAQGNEFWSALL EK---AYAKVNGSYEALSGGCTSEAFEDFTGGVTEWYDLQ-K---APSDLYQIILKALER GSLLGCSIN--------------------------------------------------- IS-------DIR------------------------------------------------ -D--LEAITFKNLVRGHAYSVTGAK-----Q-------VTY----QG---QRVNLIRMRN PWG-EVEWKGPWSDS-----------SYEWNKVDPYERE-QLRVK-MEDGEFWMSFRDF- IREFTKLEICN--LTPDALKS-RT------LR-NWNTTFYEGTWRRGST-------AGGC RNY-P-----------ATFWVNPQFKIRLEEVDD---ADDYD--NRE------------- ---------SGCSFLLALMQKHRRRERRFGRDMETIGFAVYQ---V-----P--R----E --LAGQP-VHLKRDFFLANASRAQSEHFINLREVSNRIRLPPGEYIVVPSTFEPNKEGD- -FLLRFFSEKKA------GTQ--E---LDDQIQANLPD---------------------- -------------------------------E--K-VL---SE-EEIDD-NFKT---LFS KLA-GD---------------------------------------------DMEISVKEL QTI-------------LNRII-SK------------------------------------ -------------H---------------------------KDL------RTNGFS-LES CRSMVNLM-D---RDGNGKLGLVEFNILWNRIRNYL--------------------TIFR KFDLDKSGSMSAYEMRMAIE---------------------------------------- ------AA----GFKLNKKLHELIITRYSEP-DLAVDFDNFVCCLVRLETMFRFFKLLDT DLD--GVVTFDLF--K-WLQ-LT--MFA >M_mulatta_ENSMMUP00000017716 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------MAEEIITPV-YCTGVSA------------QVQKQRA- -----KELGLGRHENAIKYLG-QDYEQLRARCLQSGTLFRDEAFPPVPQSLGFKDLGPNS SKTYGIKWKRPTELLSNPQFIVDGATRTDICQ--GAL--GDCWLLAAIASLTLNDTLLHR VVPHGQSFQN-GYAGIFHFQLWQFGEWVDVVVDDLLPIKD-GKLVFVHSAEGNEFWSALL EK---AYAKVNGSYESLSGGSTSEGFEDFTGGVTEWYELR-K---APSDLYQIILKALER GSLLGCSID--------------------------------------------------- IS-------SVL------------------------------------------------ -D--MEAITFKKLVKGHAYSVTGAK-----Q-------VNY----RG---QMVNLIRMRN PWG-EVEWTGAWSDS-----------SSEWNSVDPYERE-QLRVK-MEDGEFWMSFRDF- MREFTRLEICN--LTPDALKS-RT------IR-KWNTTLYEGTWRRGST-------AGGC RNY-P-----------ATFWVNPQFKIRLDETDD---PDDYG--DRE------------- ---------SGCSFVLALMQKHRRRERRFGRDMETIGFAVYE---D-----K--E----P -GLVGQPALHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGD- -FVLRFFSEKSA------GTA--E---LDDQIQANLPD---------------------- -------------------------------E--Q-VL---SE-EEIDE-NFKA---LFR QLA-GE---------------------------------------------DMEISVKEL RTI-------------LNRII-SK------------------------------------ -------------H---------------------------KDL------RTKGFS-LES CRSMVNLM-D---RDGNGKLGLVEFNILWNRIRNYL--------------------SIFR KFDLDKSGSMSAYEMRMAIE---------------------------------------- ------SA----GFKLNKKLYELIITRYSEP-DLAVDFDNFVCCLVRLETMFRFFKTLDT DLD--GVVTFDLF--K-WLQ-LT--MFA >C_familiaris_ENSCAFP00000020396 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------MAEEIITPV-YCTGVSA------------QVQKQRA- -----KELGLGRHENAIKYMG-QDFEQLRAHCLQSGALFRDEAFPPVPQSLGYKDLGPNS SKTYGIKWKRPTELLSNPQFIVDGATRTDICQ--GAL--GDCWLLAAIASLTLNDTLLHR VVPHGQSFQN-GYAGIFHFQLWQFGEWVDVVVDDLLPIKD-GKLVFVHSAQGNEFWSALL EK---AYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELR-K---APSDLYQIILKALER GSLLGCSID--------------------------------------------------- IS-------SVL------------------------------------------------ -D--MEAITFKKLVKGHAYSVTGAK-----Q-------VNY----QG---QMVSLIRMRN PWG-EVEWTGAWSDG-----------MLRGNNVDPSERE-QLRVK-MEDGEFWMSFRDF- MREFTRLEICN--LTPDALKS-RS------IR-KWNTTLYEGTWRRGST-------AGGC RNYHP-----------ATFWVNPQFKIRLEETDD-V-DDDYG--GRE------------- ---------SGCSFVLALMQKHRRRERRFGRDMETIGFAVYE---A-----S--H----Q --LVGQPAVHLKRDFFLANSSRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGD- -FVLRFFSEKSA------GTE--E---LDDQIQANLPD---------------------- -------------------------------E--Q-VL---SE-EEIDE-NFKA---LFR QLA-GE---------------------------------------------DMEISVKEL QTI-------------LNRII-SK------------------------------------ -------------H---------------------------KDL------RTKGFS-LES CRSMVNLM-D---RDGNGKLGLVEFNILWNRIRNYL--------------------SIFR KFDLDKSGSMSAYEMRMAIE---------------------------------------- ------SA----GFKLNKKLYELIITRYSEP-DLAVDFDNFVCCLVRLETMFRFFKTLDT DLD--GVVTFDLF--K-WLQ-LT--MFA >D_rerio_ENSDARP00000013018 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------MEPI-CATGMAA------------RLRSQWD- -----RDAGLGQNHNAVKFLG-QDYETLRAQSQQSRRLFEDPMFTASSSSLGFNELGPRS SKTQGVRWMRPKEMCARPQFIVDGATRTDICQ--GAL--GDCWLLAAIASLTLNDNLLHR VVPHGQDFDS-RYAGIFHFQFWQFGEWVDVVIDDRLPTKD-GKLLFVHSAEGGEFWSALL EK---AYAKLNGCYEALSGGSTCEGFEDFTGGVTEMYELK-K---APADLFSIIGRAIER GSLLGCSID--------------------------------------------------- IT-------SKF------------------------------------------------ -D--MEAVTFKKLVKGHAYSVTGAE-----E-------VVY----RG---NMTKLVRIRN PWG-EVEWTGAWSDN-----------SREWDNVDRSVRG-RLQNR-SEDGEFWMSFSDF- LREFTRLEICN--LTADALQA-SQ------VK-KWSTANYNGEWRRGST-------AGGC RNY-P-----------ATFWINPQFKVALKHPDS----------PGQ------------- ---------SECSFLVALMQKDRRKKRREGQDMETIGFAIYE---V-----P--R----E --FLGQSGVHLKRDFFLTHASSARSELFINLREVSSRFRLPAGEYIIVPSTFEPNKEAD- -FVLRVFSEKPA------NSE--E---MDDKVMAEIPE---------------------- -------------------------------E--Q-RL---DE-SQIDA-GFKS---LFR QLA-GA---------------------------------------------DMEISVTEL QTI-------------LNRII-AK------------------------------------ -------------H---------------------------KDL------KTDGFG-KES CRSMINLM-D---TDGSGKLGLVEFHVLWEKIKRYL--------------------QIFR DHDVDKSGTMSSYEMRKALE---------------------------------------- ------TA----GFKLNNHLFQLIILRYTEE-DLSVDFDNFVSCLVRLETMFKTFKSLDT DAD--GVISLTFF--Q-WIT-LT--MFA >B_taurus_ENSBTAP00000011676 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MAALAA------------RVTRQRA- -----ATEGLGSSQKAVRYLG-QDFETLRQQCLDSGLLFKDPEFPACPSALGYKDLGPCS PRTQGVVWKRPMELCPSPQFIVGGATRTDICQ--GAL--GDCWLLAAIASLTLNRELLYR VVPRDQSFQE-NYAGIFRFQFWQYGEWVEVVVDDRLPTKN-GKLLFLHSEEGSEFWSALL EK---AYAKLNGSYEALTGGSTVEGFEDFTGGISEFYNLK-K---PPASLFQIIQKALRS GSLLACSID--------------------------------------------------- IS-------SAA------------------------------------------------ -E--TEAITSQKLVKGHAYSVTGVE-----E-------VDF----RG---CPERLIRLRN PWG-EVEWKGAWSDD-----------APEWNYIDPRQKE-QLGKK-AEDGEFWMSFSDF- LRQFSRLEICN--LSLDSLSS-EE------AH-KWSLVLFNGRWTRGST-------AGGC QNY-P-----------ATYWTNPQFKIHLDEVDD---HQEEG--VSE------------- ---------PCCTVLLGLMQKNRRRQKRMGQGMLSIGYAVYK---I-----P--K----E --LESHTDAHLGRDFFLGRPPAARSSTYVNLREVSARVQLPPGEYVVVPATFEPFQDGD- -FCLRVFSEKKA------KAL--E---IGDVVVGNPH----------------------- -------------------------------E--P-RP---SE-VEQEDGQLRS---LFE KFA-GK---------------------------------------------DSEIRANEL RTA-------------LNEVF-SK------------------------------------ -------------R---------------------------TDI------KFDGFD-INT CREMISLM-D---SNGTGSLELVEFKTLWLKIRKYL--------------------DIFR ETDHNHSGTIDAHEMRTALK---------------------------------------- ------KA----GFTLSDQVQQTIAMRYACS-KLTMDFDSFIACMIRLETLFKLFRLLDK DQN--GIVQLSLA--E-WLC-CV--LV- >X_tropicalis_ENSXETP00000050337 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------MAEEVIVPV-YASGISA------------QLQKQRD- -----QELGVGKHENAVKFLG-QDYDRILHECLQNRTLFKDDTFPPSAYSLGFKELGPNS SKTYGVKWVRPSQLVSNPQFIVDGATRTDICQ--GAL--GDCWLLAAIASLTLNDTILHR VVPHGQSFQD-NYAGVFHFQLWQFGEWVDVVIDDYLPVKD-GKLVFVHSASGNEFWSALL EK---AYAKANGCYEALSGGSTSEGFEDFTGGVTEWYEMK-K---APKDLFSIIMKAVER GSLMGCSID--------------------------------------------------- IT-------SAT------------------------------------------------ -D--MEAVTFKKLVKGHAYSVTGAK-----E-------INF----RG---RSQKLIRMRN PWG-EVEWTGAWSDN-----------SSEWNSVDAADSQ-DLRIK-MEDGEFWMAFEDF- LREFSRLEICN--LTPDALTA-RK------YR-KWNTTVFNGNWRKGST-------AGGC RNF-P-----------ATFWINPQFKIKLDEEDD---DDDF---GSE------------- ---------KGCTFLLALMQKDKRKERRFGKDMETIGFAVYE---V-----P--S----Q --FHGQSGVHLKRDFFLQNASRARSEQFINLREVSTRHKLPPGEYIVVPSTFEPNVEGD- -FVVRFFSENKH------GSV--E---MDDPLSADLPP---------------------- -------------------------------E--E-VL---SE-AEIDQ-GFKN---LFK QLA-GA---------------------------------------------DNEISATEL QSI-------------LNKIM-SK------------------------------------ -------------H---------------------------KDL------RTSGFS-LES CRSMVNLM-D---KDGNGKLGLVEFNVLWNKIKNYL--------------------TVFR KFDMDKSGSMSAYEMRLAVE---------------------------------------- ------SA----GFKLTNSLHQLIITRYSEP-DMAVNFDSFTCCLIRLETMFRFFQGMDT EKK--GVIHFDIF--K-WLQ-MT--MFA >R_norvegicus_ENSRNOP00000028431 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------MAEELITPV-YCTGVSA------------QVQKQRD- -----KELGLGRHENAIKYLG-QDYENLRARCLQNGVLFQDDAFPPVSHSLGFKELGPNS SKTYGIKWKRPTELLSNPQFIVDGATRTDICQ--GAL--GDCWLLAAIASLTLNETILHR VVPYGQSFQE-GYAGIFHFQLWQFGEWVDVVVDDLLPTKD-GKLVFVHSAQGNEFWSALL EK---AYAKVNGSYEALSGGCTSEAFEDFTGGVTEWYDLQ-K---APSDLYQIILKALER GSLLGCSIN--------------------------------------------------- IS-------DIR------------------------------------------------ -D--LEAITFKNLVRGHAYSVTDAK-----Q-------VTY----QG---QRVNLIRMRN PWG-EVEWKGPWSDN-----------SYEWNKVDPYERE-QLRVK-MEDGEFWMSFRDF- IREFTKLEICN--LTPDALKS-RT------LR-NWNTTFYEGTWRRGST-------AGGC RNY-P-----------ATFWVNPQFKIRLEEVDD---ADDYD--SRE------------- ---------SGCSFLLALMQKHRRRERRFGRDMETIGFAVYQ---V-----S--Q----G --LAGQP-VHLKRDFFLANASRAQSEHFINLREVSNRIRLPPGEYIVVPSTFEPNKEGD- -FLLRFFSEKKA------GTQ--E---LDDQIQANLPD---------------------- -------------------------------E--K-VL---SE-EEIDD-NFKT---LFS KLA-GD---------------------------------------------DMEISVKEL QTI-------------LNRII-SK------------------------------------ -------------H---------------------------KDL------RTNGFS-LES CRSMVNLM-D---RDGNGKLGLVEFNILWNRIRNYL--------------------TIFR KFDLDKSGSMSAYEMRMAIE---------------------------------------- ------AA----GFKLNKKLHELIITHYSEP-DLAVDFDNFVCCLVRLETMFRFFKILDT DLD--GVVTFDLF--K-WLQ-LT--MFA >R_norvegicus_ENSRNOP00000004727 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MAALAA------------GVSKQRA- -----VAEGLGSNQNAVKYLG-QDFETLRKQCLNSGVLFKDPEFPACPSALGYKDLGPGS PDTQGIVWKRPTELCPNPQFIVGGATRTDIRQ--GGL--GDCWLLAAIASLTLNEKLLYR VLPRDQSFQK-DYAGIFHFQFWQYGEWVEVVIDDRLPTKN-GQLLFLHSEEGNEFWSALL EK---AYAKLNGSYEALVGGSTIEGFEDFTGGISEFYDLK-K---PPENLYYIIQKALRK GSLLGCSID--------------------------------------------------- VS-------TAA------------------------------------------------ -E--AEATTRQKLVKGHAYSVTGVE-----E-------VNF----HG---RPEKLIRLRN PWG-EVEWSGAWSDN-----------APEWNYIDPRRKE-ELDKK-AEDGEFWMSFSDF- LKQYSRLEICN--LSPDSLSS-EE------IH-KWNLVLFNGRWTRGST-------AGGC LNY-P-----------GTYWTNPQFKIHLDEVDE---DQEEG--TSE------------- ---------PCCTVLLGLMQKNRRRQKRIGQGMLSIGYAVYQ---I-----P--K----E --LESHTDAHLGRDFFLGRQPSTCSSTYMNLREVSSRVRLPPGQYLVVPSTFEPFKDGD- -FCLRVFSEKKA------KAL--E---IGDTVSGHPH----------------------- -------------------------------E--P-HP---RD-MDEEDEHVRS---LFE EFV-GK---------------------------------------------DSEISANQL KRV-------------LNEVL-SK------------------------------------ -------------R---------------------------TDM------KFDGFN-INT CREMISLL-D---SDGTGSLGPMEFKTLWLKIRTYL--------------------EIFQ EMDHNHVGTIEAHEMRTALK---------------------------------------- ------KA----GFTLNNQVQQTIAMRYACS-KLGVDFNGFVACMIRLETLFKLFRLLDK DQN--GIVQLSLA--E-WLC-CV--LV- >G_aculeatus_ENSGACP00000025130 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MAESI-CATGMAA------------KLRSQWD- -----RNEGLGQNHMAVKYLG-QDYEGLKAQSLQSGRAFEDHLFPCCASSLGFNELGPRS AKTSGVRWMRPAEICKRPEFIVDGATRTDICQ--GAL--GDCWLLAAIASLTLNDNLLHR VVPHGQGFQQ-GYAGIFHFQFWQFGEWVEVVIDDRLPVKD-GKLLFVHSAEGTEFWSALL EK---AYAKLNGSYEALSGGSTSEGFEDFTGGVTEMFELN-K---APPDLFSIISRAIER GSLLGCSIE--------------------------------------------------- TT-------SSS------------------------------------------------ -D--REAVTFKKLVKGHAYSVTGVE-----E-------VVY----RG---NTTKLVRIRN PWG-EVEWTGAWSDD-----------SREWDNVDRSVRA-RLQNR-SEDGEFWMSYADF- LREFSRLELCN--LTADTLQS-SQ------PK-KWSSSLYQGEWRRGST-------AGGC RNF-P-----------ATFWLNPQFKIVLQHPDA----------PGQ------------- ---------SECSFLVGLMQKDRRKKRREGQDMETIGFALYE---V-----P--N----E --FVGRSGVHLKKDFFLTHASSARSELFINLREVSSRLRLPPGEYVIVPSTFEPHKEGD- -FVLRVFSEKPA------DSE--E---LDDDVAAELPT---------------------- -------------------------------E--T-QL---DE-SQIDP-AFKN---LFR QLA-GP---------------------------------------------DMEISLTEL QTI-------------LNRIM-SK------------------------------------ -------------H---------------------------KDL------KTDGFT-KES CRSMISLM-D---TDGSGKLGLSEFHVLWEKIKRYL--------------------TIFR QFDLDKSGTMSSYEMRMALD---------------------------------------- ------SA----GFKLTNQLFQLIILRYTEA-DMSVDFDNFVTCLVRLETMFKTFHTMDT DKD--GFMSLNFN--Q-WIT-LT--MFA >D_rerio_ENSDARP00000072123 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------MEPI-CAMGVAA------------RLRSEWD- -----RNEGFGQNHMALKFLG-QDFESLRTRCLQSGHLFEDDIFPAQQSSLGFKELGPNS SKTRGVRWMRPTEFCSDPHFIVDGATRTDICQ--GAL--GDCWLLAAIACLTLNEPLLRR VVPHGQSFHQ-QYAGIFHFQFWQFGDWVDVVIDDRLPVRD-GKLLFVHSAEGSEFWSALV EK---AYAKLNGCYEALSGGSTSEGFEDFTGGVTEMYELK-N---APPNLFSIITRAVER GSLMGCSID--------------------------------------------------- IT-------SFF------------------------------------------------ -D--MEAITFKKLVKGHAYSITGVD-----E-------VEY----RR---SQTKLLRIRN PWG-EVEWTGPWSDE-----------SKEWREIDASVRS-RLHNC-QEDGEFWMAFSDF- KREFSRLEICN--LTADALQS-RE------VK-KWNSSLYPGEWRRGST-------AGGC RNY-P-----------ATFWINPQFKIVLKEPDT----------DNQ------------- ---------EGCTFLVALMQKNRRQLRREGKDMETIGFAIYE---V-----P--K----E --YLGRVGVHLKRDFFLKHTSSARSELFINLREVSSRFSLPAGEYIIVPSTFEPQKEGD- -FVLRVFSEKAT------DSQ--E---LDDEISADVPE---------------------- -------------------------------E--P-VL---QE-SDIDE-GFKA---LFA KLA-GP---------------------------------------------EMEINVAKL EMI-------------LNRVV-SK------------------------------------ -------------H---------------------------KDI------KTDGFG-KET CRGMINLM-D---TTGTGKLGLTDFHVLWEKFKRYL--------------------AVFR EFDIDKSGTMSSYEMRLALE---------------------------------------- ------SA----GFKLTNNLFQLIILRYAKS-DLNVDFDNFVACLIRLETMFKTFKTLDA DED--GLVSFSFAQ-Q-WIT-LT--MFT >O_anatinus_ENSOANP00000002295 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MAASAA------------RVSKQHA- -----ESEGLGSIWNAVKYLN-QDFEALRKQCLKSGTLFKDVEFPACPSALGFKDLGPYS PHTRGIVWKRPTELCPNPQFIVGGATRTDIRQ--GDL--GDCWLLAAIASLTLNEELLYR VVPRNQSFQK-DYAGIFHFQFWQYGEWVDVVIDDRLPTRN-GNLLFLHSEEGSEFWSALL EK---AYAKLNGSYEALTGGSTVEGFEDFTGGISEFYELK-K---APSNLYQIIQKALRS GSLLGCSID--------------------------------------------------- VS-------SAA------------------------------------------------ -E--TEAVTSLKLVKGHAYSVTGAE-----E----KLQVRH----HG---RPEKLIRLRN PWG-EVEWTGAWSDK-----------APEWNFIDPKQKE-ELDKQ-MEDGEFWMSFTDF- QRQFSRLEICN--LSPDSLSC-EE------VH-KWGLTLFNGRWIRGST-------AGGC QNY-P-----------ATYWTNPQFKICLDEADD---DHRGS--VGD------------- ---------HCCTVLLGLMQKNRRRQKRKGQGLLRIGYSIYQ---V-----P--D----S --LENHSDRHLGQDFFLGRRPSASSDSYVNLREVSGRVQLPQGEYLVVPSTLEPFKDGE- -FCLRVFSEKKA------KSL--E---IGDVVVGNPH----------------------- -------------------------------E--P-HP---HY-ADKEEEKFKS---LFE KLA-GE---------------------------------------------DSRIQVHEL RDI-------------LNETF-SK------------------------------------ -------------R---------------------------ADL------KFDGFS-LNT CREMISLL-D--QSDGLGDLGLLEFKTLWLKILKYQ--------------------EIFL EVDTNHSGTIRAHEMRTALK---------------------------------------- ------EA----GFTLSNKVQEVITVRYACS-DLSMDFDSFVACLICLETLFKMFKLLDK DQR--GVIQLSLA--E-WLF-CA--LV- >M_musculus_ENSMUSP00000047164 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MAALAA------------GISKQRA- -----AAQGLGSNQNAVKYLG-QDFETLRKQCLNSGVLFKDPEFPACPSALGYRDLGPGS AETQGIIWKRPTELCSNPQFIVGGATRTDIRQ--GGL--GDCWLLAAIASLTLNEKLLYR VVPRDQSFQK-NYAGIFHFQFWQYGEWVEVVIDDRLPTKN-GQLLFLHSEEGNEFWSALL EK---AYAKLNGSYEALAGGSTIEGFEDFTGGISEFYDLR-K---PPGNLYYTIQKALRK GSLLGCSID--------------------------------------------------- VS-------NAA------------------------------------------------ -E--AEATTRQKLVKGHAYSVTGVE-----E-------VDF----RG---LPEKLIRLRN PWG-EVEWTGAWSDS-----------APEWNYIDPQKKG-ELDKR-AEDGEFWMSFSDF- LKQFSRLEICN--LSPDSLSS-EE------IH-KWNLVLFNGRWTRGST-------AGGC QNY-P-----------ATYWTNPQFKIHLDEVDE---DQEEG--TSE------------- ---------PCCTVLLGLMQKNRRRQRRIGQGMLSIGYAVYQ---I-----P--K----E --LENHTDEHLGRDFFQGRQPSTCSSTYMNLREVSSRVQLPPGQYLVVPSTFEPFKDGD- -FCLRVFSEKKA------QAL--E---IGDAVAGDPH----------------------- -------------------------------E--P-HP---RD-MDGEDEHFWS---LSE EFA-DK---------------------------------------------DSEISAHQL KRV-------------LNGLL-SK------------------------------------ -------------R---------------------------TDM------KFDGFN-INT CREMISLL-D---GDGTGSLRPVEFKTLWLKICKYL--------------------EIYQ EMDHSRAGTIDAHEMRTALK---------------------------------------- ------KA----GFTLNNQVQQTIATRYACS-KLGVDFDGFVACMIRLEILFKLFRLLDK DQN--GIVQLSLA--E-WLC-CA--LV- >X_tropicalis_ENSXETP00000040289 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MSNIAA------------RLAKSRAA -----AADGLGTNKNPVQYLN-QDFEKLRAQCLASGTLFKDEEFPACPSALGFNELGPGS PKTQGVIWKRPSEICPNPQFIVDGATRGDIRQ--GAL--GDCWLLAAIASLTLDADLVAQ VVPENQSFQK-DYAGIFHFRFWQYGEWVDVVVDDRLPTKN-GNLVFVHSAEGDEFWSALL EK---AYAKLNGSYEALSGGSTIEGFEDFTGGIAEVYELR-K---APSDLFQIIQKALRA ESLLGCSID--------------------------------------------------- IT-------NAY------------------------------------------------ -D--TEAITSRKLVKGHAYSVTGAE-----E-------VLY----RG---RQEKLIRVRN PWG-EVEWTGPWSDT-----------APEWNYIDPKVKA-ALDKQ-SDDGEFWMAFSDF- LREYSRLEICN--LSPDTLTN-TE------QH-KWNITLYNGSWARGST-------AGGC QNY-P-----------ATFWTNPQFRIKLDEPDH---EHQGS--NQE------------- ---------PCCTVIVGLMQKNRRRKKKMGEDLLSIGYSLFK---V-----S--I----S --LSSIVLLYI----YMRTPTAARSDTYINVREVSNR-HLPVGDYLIVPSTFEPFKNGD- -FCLRVFSEKEA------KSL--E---VGDVVIAKPY----------------------- -------------------------------E--P-KI---SN-KDVTD-EFKN---IFD KLA-GD---------------------------------------------KEEIDAKEL QTI-------------LNKLI-SK------------------------------------ -------------R---------------------------PDL------RSNGFT-VNT CREMISLQ-D---MDGTATLSLLEFRILWLKIQKYL--------------------AIYL KADSDRSGTMDAHELRAALQ---------------------------------------- ------EA----GFTLNNKIQQSIVLRYASD-ELTINFDGFIACMMRLETLFKMFQMLEK SKK--GVVELSLQ--E-WLC-AT--LV- >T_nigroviridis_ENSTNIP00000010246 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------VTPTMVEQIYHATGMAY------------KLRSQWD- -----RDEGLGQNHKAVKFLG-QDYELLKSQSLQSGRLFEDNLFPCSASSLGFNELGPRS SKTSGVRWMRPPEICKRPEFIVDGATRTDICQ--GAL--GDCWLLAAIASLTLNDNLLHR VVPHGQSFAH-GYIGIFHFQFWQFGEWLDVVIDDRLPVKD-GKLLFVHSAEGTEFWSALL EK---AYAKLNGCYEALSGGSTSEGFEDFTGGVTEMYELQ-K---APSDLYSIICRALER GSLLGCSIN--------------------------------------------------- IT-------SKF------------------------------------------------ -D--MEAVTFKKLVKGHAYSVTAAD-----E-------VAY----RG---TPTKLVRIRN PWG-EVEWTGPWSDN-----------SREWDSVDRSVRG-RLQNC-SEDGEFWMSLQRLP LREFTTLEICN--LTPDALQN-AQ------LK-KWSTSLYQGEWRRGST-------AGGC RNY-P-----------ATFWLNPQFKLMLKNPDM----------PGQ------------- ---------ADCSFLVGLMQKDRRKKRREGQDMETIGFAIYE---V-----P--Q----E --MAGRSGVHLKRDFFLTHASSARSEVFINLREVSSRLRLPAGEYIIVPSTFEPHKEAD- -FVLRVFSEKPA------QSE--E---LDDEIKADIPK---------------------- -------------------------------E--E-RL---DE-SQIDA-GFKS---LFR QLA-GP---------------------------------------------DMEISITEL QTI-------------LNRII-SK------------------------------------ -------------H---------------------------KDL------KTDGFS-KES CRSMINLM-D---LDGSGKLGLTEFHVLWEKIKRYL--------------------TIFR TFDMDKSGTMSSYEMRMALE---------------------------------------- ------SA----GFKLTNNLFQLIILRYTEA-DMSVDFDNFVTCLVRLETMYKTFDSLDT DKD--KVISLNFFQ-Q-WIS-LT--MFA >O_latipes_ENSORLP00000014855 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SWESAHTQVRMTSFAK------------RVAHQQN- -----RAEGVGTIENAVKFCQ-QDFETLRQECLSSGRLFEDGCFPAQSKSLGYKELGPYS SKTKGIVWKRPTELCSNPKFIDDGATRTDICQ--GSL--GDCWLLAAIASLTLDQQILAQ VVPPGQSFSE-DYAGIFHFQFWQYGEWVDVVIDDRLPTRD-GKLLFVHSEEGSEFWSALL EK---AYAKVNGCYEALSGGNTIEGFEDFTGGIGEIFSLN-K---APPQLFKIIQKALCL GSLIGCSIA--------------------------------------------------- VT-------SSY------------------------------------------------ -E--TEAVTTLKLVKGHAYSVTAAE-----E-------VNV----RG---QQVQLVRIRN PWG-QVEWTGAWSDG-----------SREWNHISQEEKS-KLNKV-AEDGEFWMSYSDF- IRNFSDLEICN--LTPDLLTD-DT------KS-CWNNYQFEGTWRVGST-------AGGC LNH-S-----------ATFPSNPQFLVHLEDVDD---DPL----DGK------------- ---------DGCTFLVGLMQKDGRRKRVLQQDLETIGFAIYK---V-----P--D----E --YKGRSNVRLGPDVLLRQRPVAMSSTFINRREVCGRFTLPPGDYAIIPSTFQPHKNGS- -FVLRVFSEKKV------DTS--R---LDVKLAAKIV----------------------- -------------------------------E--E-KI---SE-KDVDP-QFKE---MFK SAA-GG---------------------------------------------HMEVSAIEL QRI-------------LNKIF-SI------------------------------------ -------------Q---------------------------TDV------KTDGFS-LET CRLIVSLM-D---KDESGKLGPMEFRLLLTKIPKYL--------------------EIFK SLDTDNSGTMSSHEMRNAAF---------------------------------------- ------KAA--TGFQINGSVLQAIVNRYADA-QYAIDFDSFVSCLVKLEMLFKMFKALDR GGS--GKIELNMQ--Q-WLC-LA--IY- >G_aculeatus_ENSGACP00000026345 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------FVIPALVPVYSMFGGISG------------RIQKDRQ- -----RAGGLGTVQQAVPYLN-QNFQDLKEDCQQNGFLFQDPVFPAEPASLGFKELGPFT AKTRGVEWKRPTELTENPQFIVGGATRTDICQ--GAL--GDCWLLAAIGSLTLNERLLHR VVPHGQNFSQ-EYAGIFHFQFWQFGEWVDVVIDDRLPVKD-GELMFVHSAEGSEYWSALL EK---AYAKLNGSYEALSGGSTTEGFEDFTGGVSEMYELR-K---APRDLHRIISKALER GSLLGCSID--------------------------------------------------- IT-------SSL------------------------------------------------ -D--MEAVTFKKLVKGHAYSVTALR-----Q-------VEY----HG---NMEKLIRIRN PWG-QVEWTGAWSDS-----------SSEWTSVDPAEKD-ELLCQ-MEDGEFWMSFQDF- LRQFSRLEICN--MTPDALSQ-DS------SS-FWTTTMFEGGWRRGST-------AGGC RNH-P-----------NTFWINPQYKVSLLEEDD---DPT----DEE------------- ---------PACSLLVALMQKDRRRYRRHGQDVHTIGFAIYE---V-----P--E----E --YRGRASVHMKKDFFLRHSSCARSETFINLREVSARLRLPPGAVNGGAVNLRPSKEMN- -FDLL----------------------------AILPC---------------------- -------------------------------K--E-EV---LV-NDVDE-SFRS---MFA QLS-GD---------------------------------------------DMEISVQEL RTV-------------LNRVM-SK------------------------------------ -------------H---------------------------GDL------QTDGFS-MES CRAMVSLM-D---KDGSARLGLLEFQVLWNKIRKWL--------------------GIFR EFDLDKSRCMNAYEMRLALG---------------------------------------- ------EG----GFKLNNKLYQMLVARYADN-EI-IDFDNFTCCLVKLEAMFKAFQELDR DGT--GRVELNIS--E-WLY-VT--MCG >M_domestica_ENSMODP00000006154 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MAAMAG------------RLSKQQLF -----VSEGLGSSQNAVKYLD-QDFETLRKQCLESGTLFKDPEFPACPSALGYKDLGPYS PQTQGIIWKRPTELCPDPQFIIGGATRTDVRQ--GAL--GDCWLLAAIASLTLNEELLYR VVPKDQSFQK-NYAGIFHFQFWQYGEWVDVVIDDRLPTRN-GNLLFLHSEEGREFWSALM EK---AYAKLNGSYEALTGGSTVEGFEDFTGGISEFYDLK-K---PPSNLYQIIRKALRS GSLLGCSID--------------------------------------------------- IT-------NAS------------------------------------------------ -E--SQEITSLKLVKGHAYSVTGVE-----E-------VNY----RG---CLEKLIRLRN PWG-GTEWTGAWSDS-----------APEWNYIDPRQKK-ELDKK-AEDGEFWMSFSDF- LRQFSRLEICN--LSPDSLTS-EE------IH-KWNMTLFNGRWIRGST-------AGGC QNY-P-----------ATYWTNPQFKIRLDEADD---HHEGN--PSE------------- ---------PCCTVLLGLMQKNSRRKKRMGQGMLSIGYSLYQ---V-----L--H---IW --LENHTEVHLSQDFFLGHQPAAKTPAYINRREVSTRIHLPVGEYLVVPSTFEPFKDGE- -FFLRIFSEKEA------KSL--Y-----ELLHSDEV----------------------- -------------------------------S--N-RA---SV-GRSRKIQIYK---MTT DNR-SR---------------------------------------------DSEISANGL QTI-------------LNDFF-SK------------------------------------ -------------R---------------------------TDV------KSDGFN-INT CREMIGLL-D---NNGTGTLGLAELKILWLKIQKYL--------------------EIYQ EVDINHSGTINAHEMRMAFK---------------------------------------- ------KA----GFTLNNQVQQAIAVRYGGS-SLNIHFDSFIACMMRLESLFKIFSLLDK DHS--GTVHLSLA--E-VNG-IR--LA- >A_carolinensis_ENSACAP00000016369 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------MSEEVIVPV-YCTGVSA------------QVQKQRA- -----KDLGLGKHENAVKYLG-QDYERLRNECLQSGGLFRDETFPASAASLGFKELGPNS SKTYGVKWKRPTELCRNPLFIIDGATRTDVCQ--GAL--GDCWLLAAIASLTLNDPLLHR VVPHGQSFQN-GYAGIFHFQIWQFGEWVDVVVDDLLPTKD-GKLVFVHSAEGNEFWSALL EK---AYAKLNGCYEALSGGSTSEGFEDFTGGVTEWYDLR-K---PPSDLFQIILKALER GSLMGCSID--------------------------------------------------- IT-------SAF------------------------------------------------ -D--MEAVTFKKLVKGHAYSVTGGE-----Q-------ITY----RG---QRVSLIRIRN PWG-EVEWTGAWSDN-----------SAEWNTVDPSVGQ-QLRIK-MEDGEFWMSFQDF- LREFSRLEICN--LTPDALKS-RK------FR-KWNTTLYDGTWRRGST-------AGGC RNY-P-----------ATFWINPQFKVRLEEVDH---DDEED--SRE------------- ---------PGCSFVMALMQKHRRRERRLGKDMETIGFAVYE---V-----P--P----E --YVGQPSVHLKRDFFLSNSSRARSEQFINLREVSTRFKLPPGEYIVVPSTFDPNKEGD- -FVLRVFSENKA------GTV--E---MDDDIQANLPD---------------------- -------------------------------E--K-VL---SE-GEIDE-GFKQ---LFR QLA-GA---------------------------------------------DMEISVTEL QTI-------------LNRII-GK------------------------------------ -------------H---------------------------KDL------RTKGFS-LES CRSMVNLM-D---RDGNGKLGLVEFNILWTKIRGYL------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------- >T_rubripes_ENSTRUP00000020397 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------LGQNHKAVKFLG-QDYERLKTQSLQSGRLFEDNLFPCSASSLGFNELGPRS SKTSGVRWIRPTEICKRPEFIVDGATRTDICQ--GAL--GDCWLLAAIASLTLNDNLLHR VVPHGQSFAH-GYIGIFHFQFWQFGEWVDVVIDDRLPVKD-GKLLFVHSAEGTEFWSALL EK---AYAKLNGCYEALSGGSTSEGFEDFTGGVTEMYELR-K---APSDLYSIISRALER GSLLGCSIN--------------------------------------------------- VS-------LTTVIRLRQRRSPSLGILGSGIAEDLDGDKVSETETFFTSRNVHPTDAILW PL--MEAVTFKKLVKGHAYSVTAAD-----E-------VVY----RG---SPTKLVRIRN PWG-EVEWTGPWSDN-----------SREWDNVDRSVRS-RLQNR-SEDGEFWMGFNDF- LREFTTLEICN--LTPDALQN-AQ------LK-KWSTSLYQGEWRRGST-------AGGC RNY-P-----------ATFWLNPQFKLVLKNPDV----------PGQ------------- ---------SECSFLVGLMQKDRRKKRRDGEDMETIGFAIYE---V-----P--R----E --MAGRSGIHLKRDFFLTHASSARSELFINLREVSSRLQLPAGEYVIVPSTFEPHKEAN- -FVLRVFSEKPA------QSEYSE---GGETVKHDRPSIKKTNAEF-------------- -----------------------------VFQ--E-RL---DE-SQIDA-GFKS---LFR QLA-GP---------------------------------------------DMEISITEL QTI-------------LNRII-SK------------------------------------ -------------H---------------------------KDL------KTDGFS-KEA CRSMINLM-D---EDGSGKLGLTEFHVLWEKIKRYL--------------------TIFR TFDLDKSGTMSSYEMRMALE---------------------------------------- ------SA----GFKLNNNLFQLIILRYTEA-DMSVDFDNFVTCLVRLETMYKTFNSLDT DKD--KVISLNFF--Q-WIT-LT--MFA >O_latipes_ENSORLP00000025870 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------SSSRTMSGVAS------------TLAKKRA- -----LAAGFGTNANAVPYLN-QNFEALRAQSLSSGQLFCDPAFPAAPESLGFNELGRSS AKTRGVTWKRPKELVSNPEFILGGATRTDICQ--GAL--GDCWLLAAIASLTLNEFVMAR VVPMDQGFGK-DYAGIFHFQLWILGVLKLLVVFKLDVKKL-KEPVGPVPNRGPEQLVK-L SN---GPELVNGCYEALSGGSTTEGFEDFTGGIAENFDLR-E---PPSNLFQILKKALEA GALLGCSID--------------------------------------------------- IT-------SAA------------------------------------------------ -D--SEAVTRQKLVKGHAYSLTGAT-----E-------VTY----RG---RQEKLVRMRN PWG-QVEWTGAWSDG-----------SSEWNDVQGDCPH----AN-AEDGEFWMSFNEF- LRNYSRVEVCT--LTPDTIDD-ES------IK-HWSVSKFDGTWRRGST-------AGGC RNH-P-----------YTFWTNPQFVIKLDEEDD---DPD----DGE------------- ---------VGCSFVVGLIQKNRRNLRKQGEDMHTIGFAIYE---L-----P--E----Q --YHGQREVHLDKNFFLTHAQKARSETFINLREVSTRFKLPPGEYLIVPSTFDPHLNAD- -FCIRVFSEKQA------ETL--P---CDDPVSAELSNPSYI------------------ -------------------------------Q--D-AV---SD-AEVDS-GFRN---LFM KLA-GN---------------------------------------------DMEISAVEL KTI-------------MNKIV-SK------------------------------------ -------------R---------------------------TDI------KTDGFS-MET CRIMVNLM-D--QDSGNGKLGLGEFATLWKKVQNYL--------------------NIYK KSDLDNTGTMSTPEMRLAFK---------------------------------------- ------DA----GFTLNNTIYQLLVARYSDP-DMTIDFDNFVACLMKLEMMFRVFKKLDS KGS--GSIELDLF--Q-VRT-MM--MML >E_caballus_ENSECAP00000016851 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MAALAA------------GVSRRRA- -----AAEGLGSNQKAMKYLD-QDFETLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGS PETQGIVWRRPTELCSSPQFIVGGATRTDICQ--GGL--GDCWLLAAIASLTLNEELLYR VVPRDQNFQK-NYAGIFHFQFWQYGEWVEVVVDDRLPTRN-GKLLFLHSEEGNEFWSALL EK---AYAKLNGSYEALAGGSTVEGFEDFTGGISEFYDLK-K---PPPSLYHIIRKALRS SSLLACSID--------------------------------------------------- VS-------SVA------------------------------------------------ -E--TEAITRQKLVKGHAYSVTGVE-----E-------VDF----QG---HPEKLIRLRN PWG-EVEWTGAWSDD-----------APEWSYIDPRQKE-KLDKK-AEDGEFWMSFADF- LRQFSRLEICN--LSPDSLSS-EE------VH-RWNLVLFNGRWTRGST-------AGGC QNY-P-----------ATYWTNPQFKIHLDEVDD---HQEES--EGE------------- ---------PCCTVLLGLMQKNRRRQKRMGQGMLSIGYAVYK---Q-----P--T----R --FFACRDKNLRRHFRTHVPSTCVSEHSRCSLLGKARGYYPPGAHLLGEVRHTPLTAGQD PFCPHLLSAVSA------VLR--E---MGNVVAGDLH----------------------- -------------------------------E--P-HP---SE-VDQEDGQFES---LFE RLA-GK---------------------------------------------DSEIGANEL KKV-------------LNEVF-SK------------------------------------ -------------R---------------------------TDI------KFDGFD-INT CREMISLM-D---NNGTGTLGPVEFKTLWLKIRKYL--------------------EIYQ ETDYNHLGTIDAHEMRTALK---------------------------------------- ------KA----GFTLNNQVQQTIALRYACS-KLGIDFDGFVACMIRLETLFKLFRLLDK DQS--GIVQLSLA--E-WLC-CV--LV- >C_familiaris_ENSCAFP00000024188 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SQPSGRCQVSKGSSRSACLSPVSPAEPTDMSALAA------------RIAKQQA- -----AAGGLGSHQKAVKYLG-QDFEKLRQQCLDAGVLFKDPEFPACPSALGHKDLGPQS PQTQGIVWKRPPELCANPQFIVGGATRTDICQ--GSL--GDCWLLAALASLTLNQELLHR VVPRGQDFQQ-NYAGIFHFQFWQYGEWVEVVVDDRLPSKD-GELLFLHSETGNEFWGALL EK---GLGGLNGSYEALTGGSTVEGFEDLTGGISEYYDLK-K---PPARLFQIIQKALRA GSLLACSIH--------------------------------------------------- VS-------SAA------------------------------------------------ -EAGAEVTTRHKLVKSHAYSVTGVI-----E-------VDF----RG---RPEKLIRLRN PWG-EVEWTGAWSDD-----------APEWNDIDPRQKE-ELDRR-AEDGEFWMSFLDF- LGQFSRLEICN--LSPDSLSS-EE------LH-KWNLVLFNGRWTRGSS-------AGGC ANF-P-----------ATYWTNPQFKIHLDEVDD---SQEGC--VSK------------- ---------PHCTVLLGLMQKNCRRQKSTGQGMLSIGYAVYK---I-----D--G----P --LESPADTPLGQNFFLGRQPFARSSAHANLREVSSRLLLPPGEYLLVPSTFEPFQDGD- -FCLRVFSQKKA------KAL--E---LGDGVAGNPH----------------------- -------------------------------E--P-HP---SE-VDQEDSRFGS---LLG TLA-GK---------------------------------------------DSEIGANEL RTI-------------LNEVF-SK------------------------------------ -------------V---------------------------SAL-----CSSPGFC-WEG CSGYIHFL-K---NSGTGLLGLAELRTLWLKLRKYL--------------------EIYR ETNDNHSGSIDTHEMRTALR---------------------------------------- ------NA----GFMLSTQVQQTVALRYADS-RLSIDFDDFVACVARLESLFKLFRLLDK DQR--GTVRLSLA--E-WLC-CV--LV- >T_guttata_ENSTGUP00000014935 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------MAEPPVVPV-FCTGVSA------------QVRRQRA- -----KELGLGRHDNAVRYLG-QDFGQLAEECRRSGTLFQDPSFPPAATSLGFRELGPGS SKTRGVQWKRPTELCPRPQFIVDGATRTDICQ--GAL--GDCWLLAAIASLTLNETFLHR VVPHGQSFQQ-GYAGIFHFQIWQFGEWLDVVVDDFLPTKD-GKLLFVHSAEGSEFWSALL EK---AYAKVNGCYEALSGGSTSEGFEDFTGGVTEWFDLR-R---PPADLYQIILKALER GSLLGCSID--------------------------------------------------- IT-------SAF------------------------------------------------ -D--MEAVTFKKLVKGHAYSVTGAK-----Q-------IPY----RG---QALELIRMRN PWG-EVEWTGAWSDG-----------SAEWHAVEPALRQ-QLMVK-MEDGEFWMSFRDF- LREFTRLEICN--LTPDALQS-RK------FR-KWNTRLYDGTWRRGST-------AGGC RNY-P-----------ATFWINPQFKIQLEEVDD---ERDEDG-GRE------------- ---------PGCSFLLALMQKHRRRERRYGKDMETIGFAVYE---V-----P--P----E --YVGRSGVHLKREFFLANASRARSEQFINLREVSTRFRLPPGEYIVVPSTFEPNKEGD- -FVLRVFSEKRA------GTE--E---MDDKIQATLPD---------------------- -------------------------------E--K-VL---GE-SEIDE-NFKQ---LFR QLA-GP---------------------------------------------RLLMSVIGC DII-------------CCDII-GK------------------------------------ -------------N---------------------------GNR------GNLGICVLDN GRHPAKLL-Q---KDGNGKLGLVEFNVLWNRIRNYL--------------------SIFR KFDLDKSGS--------------------------------------------------- ------------------------------------------------------------ ---------------------------- >O_latipes_ENSORLP00000010389 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------PEFIVDGATRTDICQ--GAL--GDCWLLAAIASLTLNDNLLHR VVPHGQCFKQ-GYAGIFHFQFWQFGEWVDVVIDDRLPAKD-GKLLFVHSVEGTEFWSALL EK---AYAKLNGCYEALSGGSTSEGFEDFTGGVTEMYDLI-K---PPPDLFGIISRAVER GSLLGCSID--------------------------------------------------- IT-------SST------------------------------------------------ -D--REAVTFKKLVKGHAYSLTGVD-----E-------INV----MG---QETQLGRLEN FFG-KTPWGGLKPLS-----------SKEWSYVDSSVRD-RLQNR-SEDGEFWMAFSDF- LREFSRVEICN--LTADALDN-TQ------MK-KWSSSLFQGEWRRGST-------AGGC RNY-P-----------ATFWLNPQFKISLQHPDV----------SGK------------- ---------PDCSFLVGLMQKDRRKKRQEGKDMETIGFALYE---V-----P--D----E --FKGSSNVHLKRDFFLTHASSARSELFINLREVSSRLRLPAGEYIVVPSTFEPNKEAD- -FVLRVFSEKPA------DSE--E---LDDDVVADLPK---------------------- -------------------------------E--KILL---DE-SQIDA-GFKS---LFK QLA-GP---------------------------------------------DMEISVTEL QNI-------------LNKII-SK------------------------------------ -------------H---------------------------KDL------KTDGFT-PEA CRSMINLM-D---TDGSGKLGLKEFHVLWEKIKRYLYEYKHKQSAVCYFSHTLTCQTIFR QFDLDKSGTMSSYEMRIALE---------------------------------------- ------SA----GFKLTNHLFQLIILRYTEE-DMSVDFDNFVTCLVRLETMFKTFKTLDT DAD--GQISLNFF--Q-WIT-LT--MFA >E_caballus_ENSECAP00000004727 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------EAVLSKGMAA------------HISQSRL- -----KAKGVGRYNNAQSYSN-QIFEELRAVCLRKGELFEDPLFPAEHSSLGFKDLGPDS KNAQNIRWQRPTQITSNPQFIVDGVGPTDICQ--GVL--GDCWLLAAIGSLTTYPKLLNR VVPKGQSFKK-NYAGIFHFQIWQFGQWVDVVVDDRLPTKN-GKLVFVHSPERTEFWSALL EK---AYAKLNGSYEALSGGNTVEGFEDFTGGVTQSLQLQ-R---PPRNLLRMLRKAIER SSLLGCSIE--------------------------------------------------- IT-------SNS------------------------------------------------ -D--LESLTQKMLVRGHAYSVTGLQ-----D-------VLY----QG---KMETLIRVRN PWG-RIEWNGSWSDN-----------AREWEEVDLDIQK-QLLHK-KEDGEFWMSYQDF- LNNFTLLEICN--LMPDTLSG-DC------KS-SWHATFYEGSWRRGST-------AGGC RNY-L-----------DTFWTNPQFKISLPEEDD---DPE----NNE------------- ---------VVCTCLVALMQKNWRQARPQGAQLQTIGFVIYT---V-----P--K----E --FQNIQDIHLKKDFFMKYQDHGFSEIFSNAREVSSHLRLPPGDYIIIPSTFEPHKDAD- -FLLRVFTEKHS------ESW--E---LDEANYAEMLQ---------------------- -------------------------------E--E-NI---SE-DKVNQ-DFTR---LFE TVAGGE---------------------------------------------GKEIGMYGL QKL-------------LNKVV-SK------------------------------------ -------------F---------------------------THF------KTQGFG-LDV CRCMVNLM-D---KDDSGKLGFLEFQILWKKIKKWT--------------------DIFR ECDEDNSGALNSYEMRLAIE---------------------------------------- ------KA----GIKLNNKVMQVLVARYANK-NMMVDFDSFIYCFLKLKAMFRYFLTMDP RNT--GYIHLNLN--E-WLQ-IT--MWG >B_taurus_ENSBTAP00000004690 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------AETVFDRGIAA------------RISQNRL- -----KAKGMGQHHNAQNYNN-QSFEELRALCLRRGELFEDPFFPAEPTSLGFKELAPNS KHVQNISWQRPSQITSNPQFIVNGVSPTDICQ--GVL--GDCWLLAAIGSLTAYPKLLSR VVPKGQSFKK-NYAGIFHFQIWQFGEWMDVVVDDRLPTKN-GKLVFVHSAERTEFWSALL EK---AYAKLNGSYEALSGGNTVEGFEDFTGGVTQSFQLQ-N---PPRNLQRILRKAVER SSLALCVLQ--------------------------------------------------- VT-------HEH------------------------------------------------ -E--LESLTQGMLVRGHAYSVTGLQ-----D-------VSY----QG---RTETLIRVRN PWG-RIEWNGAWSDN-----------AKEWEEVAPDVQR-QLLHR-KEDGEFWMSYQDF- LGNFTLLEICN--VIPDTLSG-DY------KS-CWHTTFYEGSWRRGST-------AGGC RSY-L-----------DTFWTNPQFKICLPEKDD---DIE----DDE------------- ---------AVCTCLVALMQKNWRRTRPHGAQLETIGFVIYS---I-----P--K----E --FQNLQDVHLKKDFFVKYQDLGFSEIFTNSREVSSQFQLPPGEYIIIPSTFEPHKDAD- -FLLRVFTEKHS------ESW--E---LDEANYAELLQ---------------------- -------------------------------E--E-SI---SE-TDIDQ-DFVR---LFH IVAGGE---------------------------------------------GKEIGMYEL QKL-------------LNKVV-SR------------------------------------ -------------F---------------------------KNF------KTKGFS-LDV CRCMVNLL-D---KDGSGKLGLREFQVLWRKIKKWT--------------------DIFR ECDQDQSGTLNSYEMRLAVE---------------------------------------- ------KA----GIKLNNKVTQVLVARYAND-SLIMEFDSFISCFLRLKAMFTYFLTMDP ENT--GQISLDLN--Q-WLQ-IT--MWG >T_nigroviridis_ENSTNIP00000013441 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------MPYTPSGFFCD------------RLIRERE- -----RRDGEGSLNKPIRFNS-QDYSVLRQECVHRKSLFEDDTFPATVESLGYKELGHKS NKVKNIVWKRPKEICDNPQFIVGGASRTDICQ--GDL--GDCWLLAAIACLTLNEKLLYR VVPPEQSFSE-SYAGIFHFQFWRYGDWVDVVIDDRIPTFN-NQLVFTKSAERNEFWSALL EK---AYAKLHGSYEALKGGNTTEAMEDFTGGVTEFYEMK-E---APKELYKIMKKALDR GSLMGCSID--------------------------------------------------- SL-------VPA------------------------------------------------ -R--FETRTATGLVKGHAYSVTAVE-----E----CKPSQH----KE---SKVRLVRLRN PWG-QVEWNGPWSDN-----------SKEWSTLSKAEKE-KLHHQSAEDGEFWMSFEDF- KKNYTKIEICN--LTPDALED-DK------IH-KWTVSVNEGRWVRGCS-------AGGC RNY-P-----------DTFWTNPQYRLRLLEEDD---DPE----ENE------------- ---------VGCTFVVALMQKNRRKERKMGANLFTIGFAIYE---V-----P--K----E --MHGN-KQHMQKDFFLYSSSKARCKSYINLREVTQRFRLSPGEYVIVPSTYEPHQEGE- -FILRVFSEKKN------TSE--E---IENRIEADHPE---------------------- ------------------------------PAPAS-AG---EE-SEEDQ-QFRT---IFQ EIA-GD---------------------------------------------DMEITANEL KNV-------------LNRVI-IK------------------------------------ -------------H---------------------------KDM------KTEGFS-LES CRSMIALM-D---MDGTGRLNLQEFRHLWTKIKQWQ--------------------GIFK HYNADQSGFINSYEMRNAVN---------------------------------------- ------DA----GFRLNNQLYDIITMRYANE-NMNIDFDSFISCLVRLEAMFRAFQAFDQ EGD--GTIRLSVL--E-WLQ-LT--MYA >G_aculeatus_ENSGACP00000006949 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------MPYTPSGFFCD------------RLIRERE- -----RRDGEGSLNKPLRFNG-QDFNALRQECLQRKSPFEDDSFPATVESLGFKELGHKS NKVKNIVWKRPKEICENPQFIVGGASRTDICQ--GDL--GDCWLLAAIACLTLNEKLLYR VVPQEQSFSE-GYGGIFHFQFWRYGDWVDVVIDDRIPTFN-NQLVFTKSAERNEFWSALL EK---AYAKLHGSYEALKGGNTTEAMEDFTGGVTEFYELK-E---APKELYKIMKKALLR GSLMGCSID--------------------------------------------------- SL-------VPA------------------------------------------------ -R--FETRTATGLVKGHAYSVTAVD-----E----CKPSQQ----KD---SKVRLVRLRN PWG-QVEWNGPWSDN-----------SKEWANLSAAEKE-KLQHQSAEDGEFWMSFEDF- KKNYTKIEICN--LTPDALED-DK------IH-KWTVSVNEGRWVKGCS-------AGGC RNY-P-----------DTFWTNPQYRLRLLEEDD---DPE----DNE------------- ---------VGCTFVVALMQKNRRKERKMGANLFTIGFAIYE---V-----P--K----E --MHGN-KQHMQKDFFVFSSSKARCKSYINLREVTQRFRLSPGEYVIVPSTYEPHQEGE- -FILRVFSEKKN------TSE--E---IENRIEADHPV---------------------- ------------------------------PAPAS-VG---EE-SEEDQ-QFRT---IFQ EIA-GD---------------------------------------------DMEITANEL KNV-------------LNRVI-TK------------------------------------ -------------H---------------------------KEL------NTKGFS-LES CRSMIALM-D---MDGTGRLNLQEFRHLWNKIKQWQ--------------------GIFK HYNADQSGSINSYEMRNAVN---------------------------------------- ------DA----GFRLNNQLYDIITMRYANE-GMNIDFDSFISCLVRLEAMFRAFQAFDQ DGD--GTIRLSVL--E-WLQ-LT--MYA >T_rubripes_ENSTRUP00000016935 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------MPYTPSGFFCD------------RLIRERE- -----RRDGEGSLNKPIRFNN-QDYSVLRQECVHRKSLFEDDTFPATVESLGYKELGHKS NKVKNIVWKRPKEICENPQFIVGGASRTDICQ--GDL--GDCWLLAAIACLTLNEKLLYR VVPSEQSFSE-GYVGVFHFQFWRYGDWVDVVIDDRIPTFN-NQLVFTKSAERNEFWSALL EK---AYAKLHGSYEALKGGNTTEAMEDFTGGVTEFYEMK-E---APKELYKIMKKALDR GSLMGCSID--------------VSHTQ-------------RGVLGGELG-RDASVVSLQ SL-------VPA------------------------------------------------ -R--FETRTATGLVKGHAYSVTAVE-----E----V---AH----KD---AKVRLVRLRN PWG-QVEWNGPWSDN-----------SKEWSTISKAEKE-KLHHQSAEDGEFWMSFEDF- KKNYTKIEICN--LTPDALED-DK------IH-KWTVSVNEGRWVRGCS-------AGGC RNY-P-----------DTFWTNPQYRLRLLEEDD---DPE----ENE------------- ---------VGCTFVVALMQKNRRKERKMGANLFTIGFAIYE---V-----P--K----E --MHGN-KQHMQKDFFLFSSSKARCKSYINLREVTQRFRLSPGEYVIVPSTYEPHQEGE- -FILRVFSEKKN------TSE--E---IENRIEADHPE---------------------- ------------------------------PAPAS-AG---EE-SEEDQ-QFRT---IFQ EIA-GD---------------------------------------------DMEITANEL KNV-------------LNRVI-IK------------------------------------ -------------R--ELFPSIPAGTAHSGGSDSCPRLPADKDM------NTEGFS-LES CRSMIALM-D---MDGTGRLNLQEFRHLWNKLKQWQ--------------------GTFK HYDADQSGFINSYEMRNAVN---------------------------------------- ------DA----GFRLNNQLYDIITMRYANE-NMNIDFDSFISCLVRLEAMFRAFQAFDQ DGD--GTIRLSVL--E-WLQ-LT--MYA >H_sapiens_ENSP00000381758 MLYSPGPSLP-----------------ESAESL--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------DGSQEDKPR-GSCAEPTFTDTGMVA------------HINNSRL- -----KAKGVGQHDNAQNFGN-QSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNS KNVQNISWQRPKDIINNPLFIMDGISPTDICQ--GIL--GDCWLLAAIGSLTTCPKLLYR VVPRGQSFKK-NYAGIFHFQIWQFGQWVNVVVDDRLPTKN-DKLVFVHSTERSEFWSALL EK---AYAKLSGSYEALSGGSTMEGLEDFTGGVAQSFQLQ-R---PPQNLLRLLRKAVER SSLMGCSIE--------------------------------------------------- VT-------SDS------------------------------------------------ -E--LESMTDKMLVRGHAYSVTGLQ-----D-------VHY----RG---KMETLIRVRN PWG-RIEWNGAWSDS-----------AREWEEVASDIQM-QLLHK-TEDGEFWMSYQDF- LNNFTLLEICN--LTPDTLSG-DY------KS-YWHTTFYEGSWRRGSS-------AGGC RNH-P-----------GTFWTNPQFKISLPEGDDPEDDAE----GNV------------- ---------VVCTCLVALMQKNWRHARQQGAQLQTIGFVLYA---V-----P--K----E --FQNIQDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDAD- -FLLRVFTEKHS------ESW--E---LDEVNYAEQLQ---------------------- -------------------------------E--E-KV---SE-DDMDQ-DFLH---LFK IVA-GE---------------------------------------------GKEIGVYEL QRL-------------LNRMA-IK------------------------------------ -------------F---------------------------KSF------KTKGFG-LDA CRCMINLM-D---KDGSGKLGLLEFKILWKKLKKWM--------------------DIFR ECDQDHSGTLNSYEMRLVIE---------------------------------------- ------KA----GIKLNNKVMQVLVARYADD-DLIIDFDSFISCFLRLKTMFTFFLTMDP KNT--GHICLSLE--Q-WLQ-MT--MWG >M_musculus_ENSMUSP00000113132 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MLNYSDISWAEKGMVA------------TINHSRL- -----KDKGVGQHQNAYNYKN-QNYEDLRAECLRKGELFEDPFFPAEPRSIGVKNLGPNS EHMQNIYWQRPKDIIHNPQFITNDFSPTDICQ--GIL--GDCWLLAAIGSLTTCPKLLYR VVPRNQSFKK-NYAGIFHFQLWQFGHWLNVVVDDRLPTRN-NKLVFVHASHRQDFWSALL EK---AYAKLIGSYGALSGGSTLEGLEDFTGGVAQCIPLQ-K---PPGNMLRLLKKALEK SSLMGCSIE--------------------------------------------------- VT-------DNS------------------------------------------------ -E--VETMTHNMLVRGHAYAVTGLE-----D-------VYY----RD---KLETLIRIQN PWG-RVEWNGAWSDK-----------ATEWEEVSPDVRV-QLLHK-KDDGDFWMSYEDF- MSNFTLLEICN--LTPDALNTWDY------KS-RWHSTFYEGSWRRGST-------AGGC RNH-P-----------ETFWSNPQFKISLPEVDDPEDDSE----KNE------------- ---------MVCTCLVALMQKNWRHAR-EGPQLLTIGFVIFS---V-----P--K----E --FQNLRDIHLKKDFFLKYRDHGFSEIFINSREVNSHLRLPPGEYVIIPSTYEPHKDAD- -FLLRVFTEKHS------ETW--L---LDDANRFEHLQ---------------------- -------------------------------E--E-TV---TD-KDLDK-DSLQ---LFK IMA-NE---------------------------------------------DGEVDMYAL HKL-------------LNRMT-AK------------------------------------ -------------L---------------------------RNF------KTKGFS-LEV CRRMINLL-D---KDGSGKLELHEFQVLWKKIKKWT--------------------EIFK ECDEDRSGNLNSYEMRLAIE---------------------------------------- ------KA----GIKMNNRVTEVVVARYSD--NMIVDFDSFLNCFLRLKAMFAFFLSMDT KKT--GSICLDIN--Q-WLQ-IT--MWG >O_anatinus_ENSOANP00000015579 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GDCWLLAAIGSLTLNEELLHR VVPHGQSFQE-EYAGIFHFQIWQFGEWVDVVIDDRLPTKD-GELVFVHSAEGSEFWSALL EK---AYAKLNGSYEALSGGSTTEGFEDFTGGVAEMYELR-R---PPRNLLHIIRKALDR GSLLGCSID--------------------------------------------------- IT-------GLF------------------------------------------------ -D--MEAVTFKKLVKGHAYSVTGLR-----E-------VNY----QN---RQEPLIRIRN PWG-QVEWTGAWSDN-----------SNEWNEIDPDERD-QLQLK-MEDGEFWMSYQSL- IDALELVDIVSYLISFYLLKQ-QL------NA-SYFYVGTDPPRRHPRT-------SPSV PVP-A-----------ATFWINPQFRLRLLEEDD---DPG----DDE------------- ---------VACSCLVALMQKHRRRERRVGGDMHTIGFAIYE---V-----P--E----E --LQGSTGVHLKKEFFLRNQSRARSETFINLREVSAHVRLPPGEYVVVPSTFEPHQEAD- -FVLRVFTEKQS------DTQ--E---LDEEISADLPD---------------------- -------------------------------E--E-NL---SE-DDVDE-SFRS---MFE QLA-GE---------------------------------------------DLEISVFEL RKI-------------LNRVV-TR------------------------------------ -------------H---------------------------KDL------KTDGFS-MES CRNMVNLM-D---KDGSARLGLVEFQILWNKIRKWL--------------------TIFR QHDLDKSGTMSSYEMRLAVE---------------------------------------- ------SA----GFKLNNKLQQVLVARYADD-NMGIDFDNFVSCLVKLEAMFRFFYGLDP EGS--GTAVMDLG--Q-WLI-LT--MCG >P_pygmaeus_ENSPPYP00000000190 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MAAQAA------------GVSRQRA- -----ATQGLGSNQNALKYLG-QDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGS PQTQGIIWKRPTELCPSPQFIIGGATRTDICQ--GGL--GDCWLLAAIASLTLNEELLYR VVPRDQDFQE-NYAGIFHFQFWQYGEWVEVVIDDRLPTKN-GQLLFLHSEQGNEFWSALL EK---AYAKLNGCYEALAGGSTVEGFEDFTGGISEFYDLK-K---PPANLYQIIRKALRA GSLLGCSID--------------------------------------------------- VS-------SAA------------------------------------------------ -E--AEAITSQKLVKSHAYSVTGVE-----E-------VNF----QG---HPEKLIRLRN PWG-EVEWSGAWSDD-----------TSP--IISPSAEGCRVKHT-IMRSMSQMSLSDF- LRQFSRLEICN--LSPDSLSS-EE------VH-KWNLVLFNGRWTRGST-------AGGC QNY-P-----------ATYWTNPQFKIHLDEVDE---DQEES--VGE------------- ---------PCCTVLLGLMQKNRRRRKRIGQGMLSIGYAVYE---V-----L-------- --LCWYTLDVLGLNILASH----GSTSFLLLEEVSLLLYIP------LPVALLRIRDSF- -LW-KSRRLRHI------CPQ--A---CHDALPFWQRL---------------------- -------------------------------SPAP-HS---WM-VSLEV--------FYS ----GG-------------------------------------------------SFPRL QMI--------------FPLP-FS------------------------------------ -------------R---------------------------TDI------KFDGFN-INT CREMISLL-D---SNGTGTLGAVEFKMLWL-IQKYL--------------------EIYQ EIDYNHSGTIDAHEMRTALR---------------------------------------- ------KA----GFTLNSQVQQTIALRYACS-KLGINFDSFVACMIRLETLFKLFSLLDK DKD--GMVQLSLA--E-WLC-CV--LV- >P_troglodytes_ENSPTRP00000051120 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MAAQAA------------GVSRQRA- -----ATQGLGSNQNALKYLG-QDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGS PQTQGIIWKRPTELCPSPQFIIGGATRTDICQ--GGL--GDCWLLAAIASLTLNEELLYR VVPRDQDFQE-NYAGIFHFQFWQYGEWVEVVIDDRLPTKN-GQLLFLHSEQGNEFWSALL EK---AYAKLNGCYEALAGGSTVEGFEDFTGGISEFYDLK-K---PPANLYQIIRKALRA GSLLGCSID--------------------------------------------------- VS-------SAA------------------------------------------------ -E--AEAITSQKLVKSHAYSVTGVE-----E-------VNF----QG---HPEKLIRLRN PWG-EVEWSGAWSDD-----------ASP--VISPSAEGCRVKHT-IMRSMSQMSLSDF- VRQFSRLEICN--LSPDSLSS-EE------VH-KWNLVLFNGRWTRGST-------AGGC QNY-P-----------ATYWTNPQFKIRLDEVDE---DQEES--IGE------------- ---------PCCTVLLGLMQKNRRRRKRIGQGMLSIGYAVYQ---V-----L-------- --LCWYTLDVLGLNILASH----CSTSFLLLEEASLLLYIP------LPVALLRFRDSF- -LWLKSRRLRRI------CPQ--A---CHDALPFWQRP---------------------- -------------------------------SSVP-HP---WM-VSLEV--------FYR ----GG-------------------------------------------------SFPHL QMT-------------RFPLP-FS------------------------------------ -------------R---------------------------TDI------KFDGFN-INT CREMISLL-D---SNGTGTLGAVEFKTLWLKIQKYL--------------------EIYW ETDYNHSGTIDAHEMRTALR---------------------------------------- ------KA----GFTLNSQVQQTIALRYACS-KLGINFDSFVACMIRLETLFKLFSLLDK DKD--GMVQLSLA--E-WLC-CV--LV- >H_sapiens_ENSP00000355837 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MAAQAA------------GVSRQRA- -----ATQGLGSNQNALKYLG-QDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGS PQTQGIIWKRPTELCPSPQFIVGGATRTDICQ--GGL--GDCWLLAAIASLTLNEELLYR VVPRDQDFQE-NYAGIFHFQFWQYGEWVEVVIDDRLPTKN-GQLLFLHSEQGNEFWSALL EK---AYAKLNGCYEALAGGSTVEGFEDFTGGISEFYDLK-K---PPANLYQIIRKALCA GSLLGCSID--------------------------------------------------- VS-------SAA------------------------------------------------ -E--AEAITSQKLVKSHAYSVTGVE-----E-------VNF----QG---HPEKLIRLRN PWG-EVEWSGAWSDD-----------ASP--VISPSAEGCRVKHT-TMRSMSQMSLSDF- VRQFSRLEICN--LSPDSLSS-EE------VH-KWNLVLFNGHWTRGST-------AGGC QNY-P-----------ATYWTNPQFKIRLDEVDE---DQEES--IGE------------- ---------PCCTVLLGLMQKNRRWRKRIGQGMLSIGYAVYQ---V-----L-------- --LCWYTLDVLGLNILASH----CSTSFLLLEEASLLLYIP------LPVALLRFRDSF- -LWLKSRRLRRI------CPQ--A---CHDALPFWQRP---------------------- -------------------------------SSVP-HP---WM-VSLEV--------FYR ----GG-------------------------------------------------SFPHL QMI-------------RFPLP-FS------------------------------------ -------------R---------------------------TDI------KFDGFN-INT CREMISLL-D---SNGTGTLGAVEFKTLWLKIQKYL--------------------EIYW ETDYNHSGTIDAHEMRTALR---------------------------------------- ------KA----GFTLNSQVQQTIALRYACS-KLGINFDSFVACMIRLETLFKLFSLLDE DKD--GMVQLSLA--E-WLC-CV--LV- >R_norvegicus_ENSRNOP00000037477 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------DISYAERGMVA------------TINSNRL- -----KDKGVGQYQNAYNYKN-QNFEDLRASCLKMGELFEDPFFPAEPQSIGFKELGPKS QEVHNVYWQRPKDIIHNPQFITNDFSPTDICQ--GIL--GDCWLLAAIGSLTTSPKLLFR VVPRSQSFKK-NYAGIFHFQLWQFGHWLNVVVDDRLPTKN-NKLVFVHASHRQEFWGALL EK---AYAKLNGSYEALTGGSTMEGLEDFTGGMAQCIRLQ-N---PPHNLLRLLRKALEK SSLMGCSIE--------------------------------------------------- AT-------NSD------------------------------------------------ -D--VEKMAHNMLVKGHAYAITGLQ-----D-------VYY----RD---KLETLIRIQN PWG-RIEWNGAWSDK-----------AKEWEEVMPEVQM-QLLHK-KEDGEFWMSYEDF- MSNFTLLEICN--LTPDALSSWDY------KS-CWHTTFFEGSWRRGST-------AGGC RNY-P-----------ETFWSNPQFRISLPETDDPEDSSD----KSE------------- ---------MVCTCLVALMQKNWRHAR-EGPQLLTIGFVVFS---V-----P--K----E --FQNLQDIHLKKDFFMKYRDHGFSEIFTNTREVNSHLRLPPGEYVIIPSTFEPHKDAD- -FLLRVFTEKHS------ETW--L---LDEVNMLEQLQ---------------------- -------------------------------E--E-TI---TD-ADLDQ-NSVE---LFE TLA-NR---------------------------------------------DSQVDMYDL QKL-------------LNKMS-SK------------------------------------ -------------F---------------------------KSF------KSKGFS-LDV CRRMVNLM-D---KDDSGKLGLHEFHILWKKIKKWM--------------------EIFK ECDQDRSGNLNSYEMRLAIE---------------------------------------- ------KA----GIRMNNRVTEVVVARYADA-NMIVDFDNFINCFLRLKAMFAFFLSMDT KKT--GSICLNIN--Q-WLH-IT--MWG >O_latipes_ENSORLP00000022710 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------MPYSPPGFFCD------------RLIRERE- -----RRDGEGSVTKPLHFNG-QDFSTLRQECLQRKGLFEDDSFPATVESLGFKELGHKS NKVKNIVWKRPKEICDNPQFIVGGASRTDICQ--GDL--GDCWLLAAIACLTLNEKLLFR VVPQEQSFSE-SYAGIFHFQFWRYGDWVDVVVDDRIPTLN-NQLVFTKSAERNEFWSALL EK---AYAKLHGSYEALKGGNTTEAMEDFTGGVTEFYEMK-E---APKELYKTMKKALER GSLMGCSIDDGFCFRSGTVALKSKSHQQITRCKNDDKQRLFKAMDCGPYI-RQSKY--LQ SL-------VPA------------------------------------------------ -R--FETRTTTGLVKGHAYSVTAVD-----E---------Q----KE---SKVRLVRLRN PWG-QVEWNGPWSDN-----------SKEWATLSKAEKE-KLQHQSAEDGEFWMSFEDF- KKNYTKIEICN--LTPDTLED-DK------IH-KWTVSVNEGRWLRGCS-------AGGC RNY-P-----------DTFWTNPQYRLRLLEEDD---DPD----DNE------------- ---------VACTFVVSLMQKNRRRERKMGANLFTIGFSIYE---V-----P--K----E --MHGN-KQHLQKDFFLLNSSKARSKSYINLREVTQRFRLSPGEYVIVPSTYEPHQEGE- -FILRVFSEKRN------TSE--E---IENRIEADHPV---------------------- ------------------------------PAPAS-VG---EE-SEEDH-HFRT---IFQ EIA-GE---------------------------------------------DMEITANKL KNV-------------LNRVI-TE------------------------------------ -------------R--EFLSPPHPPSLEDVCGFCPPSTPPGKDL------NTVGFS-LES CRSMIALM-D---MDGTGRLNLQEFRHLWNKIKQWE--------------------GIFK HYNADQSGIINSYEMRNAVN---------------------------------------- ------DA----GFRLNNQLYHIITLRYANE-NMNIDFDSFISCLVRLEAMFRAFQAFDQ DGD--GTIRLSVL--E-WLQ-LT--MYA >T_guttata_ENSTGUP00000010268 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MPY------------LYQDSKP- -----RPAAHPAGARGTHSSG-KGYEQLKQECLRRGVLFEDPDFPACNSSLFFSE----- NPPIPFVWKRPGDIVKDPKFILGGATRTDICQ--GDL--GDCWLLAAIASLTLNEKTLAR VVPLDQNFGP-DYAGIFHFQFWQHNEWLDVVIDDRLPTFK-GRLVFLHSAELNEFWSALL EK---AYAKLNGSYESLKGGSTIEAMEDFTGGIGEMYDVK-A---APDNFYEILEKALKR CSMVGCSID--------------------------------------------------- TS-------SAA------------------------------------------------ -E--SEARTPFGLVKGHAYSVTGIE-----E-------VSY----RG---RQVQLIRIRN PWG-EVEWNGPWSDN-----------SAEWRSVSPSEQR-RLSQAARDDGEFWMKFEDF- KVHFDKVEICN--LTPDALED-ST------AH-KWEVTIHQGSWVRGAT-------AGGC RNF-L-----------ETFWTNPQIKLHLTEKDD---GQD-------------------- ----------DCTFIAALMQKDRRKLKKLGAEMLTIGYSIYE---S-----P--G----R -------DGHLGKDFFRYHPSKARSKTYINLREVSHRFKLPPGDYILIPTTFEPHQEAD- -FCLRIFSEKKA------ITE--D---LDESVAIDLPE---------------------- -----------------------------PLHPTP-SP---QE-TEEEK-QFRA---LFE QIS-GK---------------------------------------------DMEISAEEL EYV-------------LNAVL-KK------------------------------------ -------------T---------------------------KNI------KFKNLS-LIS CRNIISLM-D---TSGNGKLEFSEFKVFWEKLKKWI--------------------SIFL QFDFDKSGCMSSYELRGALK---------------------------------------- ------AA----GYQLNNYLLQLIVLRYSDE-QFQIEFDDFLNCLIRLENASRVFQALSV KNK--EFINLNIG--E-FIN-LA--MNI >D_rerio_ENSDARP00000094244 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------MPYTPSGFFCD------------RLIRERE- -----RRDGEGSLSKPIRFSG-QDYTLLKQEYLQKKTLFEDETFPATVDSLGYKELGHKS NKVKNIVWKRPKEICDNPQFIVGGASRTDICQ--GDL--GDCWLLAAIACLTLNDKLLYR VIPQEQSFSE-QYAGIFHFQFWRYGDWVDVVVDDRIPTFN-NQLVFTKSAERNEFWSALL EK---AYAKLHGSYEALKGGNTAEGMEDFTGGVTEFYEMK-E---APKELYKIMQKALER GSLMGCSID--------------------------------------------------- SL-------VPA------------------------------------------------ -R--FETRTATGLVKGHAYSVTAVE-----E----CKQSQQ----KE---SRVRLVRLRN PWG-QVEWNGPWSDN-----------SKEWESLSKAEKE-KLQQQNAEDGEFWMSFEDF- KKNYTKIEICN--LTPDALED-DK------LH-KWTVSVNEGRWVRGCS-------AGGC RNY-P-----------DTFWTNPQYRLRLLEEDD---DPE----DDE------------- ---------VACTFVVALMQKNRRKERKLGANLLTIGFSIYE---V-----P--K----E --MHGN-KQHMQKEFFMSTTAKARSRAYINLREVTQRFRLSPGEYVIIPSSYEPHQEGE- -FILRVFSEKRN------TSE--E---IENRIEADHPV---------------------- ------------------------------PSPAS-TG---EE-SEEDQ-QFLS---IFQ HIA-GDVSTGEAVSAWGS---------------------------------NMEVSANEL KDV-------------LNKVV-SK------------------------------------ -------------H---------------------------KDI------HTESFS-REC CRSMIALM-D---MDGTGRLNLQEFRQLWNKIKQWQ--------------------EIFK RYDFDHNDTISSYEMRNAIN---------------------------------------- ------DA----GFRLNNQLYDIITMRYANE-SMNVDFESFISCLVRLEGMFRAFQAFDQ CGD--GSIRLSVL--E-LIL-LY--IYI >G_gallus_ENSGALP00000018130 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MPY------------LLHDSKP- -----RPPPLPKEARVTHSSG-KGYQELKQECLRSGCLFEDPDFPANNASLFFSE----- KPPIPFLWKRPGDIVKDPKFILEGATRTDICQ--GDL--GDCWLLAAIASLTLNEKTLAR VVPLDQNFGP-GYAGIFHFQFWQHNEWLDVVIDDRLPTFK-DRLVFVHSAEHNEFWSALL EK---AYAKLNGSYEALKGGSTIEAMEDFTGGVGEMYEVK-K---APDNFYEILEKALKR SSMVGCSID--------------------------------------------------- TS-------SAA------------------------------------------------ -E--SEARTPFGLIKGHAYSVTGID-----E-------VSY----QG---QKVQLIRIRN PWG-QVEWNGPWSDN-----------SLEWRLVSPSEQK-RLAQTALDDGEFWMKFEDF- KVHFDKVEICN--LTPDSLED-NT------TQ-KWEVTIHEGSWVRGST-------AGGC RNF-L-----------DTFWTNPQIKLHLTEKDD---GQD-------------------- ----------DCTFIAALMQKDRRKLRKLGAEMLSIGYSIYE---S-----P--G----G -------DEHLSKDFFRYHASKARSKTYINLREVSDRFKLPPGDYILIPTTFEPHQEAD- -FCLRIFSEKKA------ITE--D---LDENVAIDLPE---------------------- -----------------------------PPNPTP-SP---QE-SEEEK-QFRA---LFE QIS-GK---------------------------------------------DMEVAAEEL EYV-------------LNAVL-KN------------------------------------ -------------T---------------------------KDI------KFKKLS-LIS CRNIISLM-D---TSGNGKLEFSEFKVFWEKLKKWI--------------------NIFL RFDFDKSGSMSSYELRSALK---------------------------------------- ------AA----GYQLNNYLLQLIVLRYSDE-QFQIDFDDFLNCLIRLENASRVFQALSV KNK--DFINLNIG--E-FIN-LA--MNI >O_latipes_ENSORLP00000024513 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AESTQWDG-KTFEQLRQECLQKGVLFEDPDFPAVDSSLFYSQ----- TVPVQIQWKRPKEICENPKFIVGGADRTDICQ--GQL--GDCWLLAAIASLTLKKDAMAR VVPPDQDFDH-NYAGIFHFQFWQHNKWLDVVVDDRLPTVR-NRLIMLHSASNDEFWSALL EK---AYAKLNGSYESLKGGSTMEAMEDFTGGVGEMYETK-S---APENLFSIMKKALDR GSMMGCSID--------------------------------------------------- IT-------SSA------------------------------------------------ -E--SEAKTSTGLVKGHAYSITGME-----E-------LQF----RG---QTVKLIRVRN PWG-QVEWNGAWSDN-----------SREWNYIDKKEKD-RILQNSLEDGEFWMEFEDF- KKNYDKVEICN--MTPDALDD-DT------KR-HWAVNVFEGNWIRGST-------AGGC RNY-I-----------DTFWTNPQFRLQLEDADD---DDD-------------------- ---------DVCSVVIALMQKNRRKLRKEGLDLETIGFAVYE---A-----P--D----D -------ESQVEKDFFRYHPSKARSRTYINMREVSERFTLPPGKYLLVPTTYQPHQEAD- -FIIRIFSEKKA------DAI--E---A-----ALFLQ---------------------- -----------------------------PPMPTP-PE---EE-TDEEK-SLRR---LFD QLA-GD---------------------------------------------DKAISVREL QQM-------------LNGVL-SR------------------------------------ -------------R---------------------------KEI------KFDGLS-LST CHSIINLM-D---VDNTGMIEFQEFKVFWEKMKNWI--------------------MLFL AFDTDRSGKMSSYELRSALK---------------------------------------- ------AA----GMQLNNQLLQLVGLRFGDD-TFNIDFDDYLTCIVRLENMFRVFQAMDK FKR--GRVKMNMM--Q-FLM-LS--MNV >D_rerio_ENSDARP00000091468 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MPY------------SVTLP--- -----GSSGQTAVVESTQADG-KTYEQLRRECLEKGKLFEDPDFPAVDGSLFYSQ----- RVPVNFEWKRPGEACANSTFFLKNTGQNNMCQWYGHA--GDCWLLAAIASLTLKEETLNR VVPNDQTFDR-GYAGIFHFQFWQHNKWMDVVVDDRLPCVR-DKLVFLHSADNNEFWSALL EK---AYAKLNGSYEALKGGSTMEAMEDFTGGVGEMYETK-N---GPNNLFLILKKAIER GSMLGCSID--------------------------------------------------- IT-------SSA------------------------------------------------ -E--SEAQTSTGLVKGHAYSVTGVE-----E-------VNY----RG---AKVQLIRVRN PWG-QVEWNGPWSDN-----------SREWTVIDSSEKK-RLLQNSLDDGEFWMEFGDF- KSNYDKVEICN--LSPDALSD-DV------SK-QWAVNLFEGSWIRGST-------AGGC RNY-I-----------DTFWTNPQFKLHLENPDD---GD--------------------- ---------KLCSVIVALMQKNRRRLRKEGLDLETIGFAIYE---A-----P--D----D -------QDHQGKDFFRYNPSKARSRTYINVREVSERFRLPPGNYLLVPTTFQPHKEAD- -FLIRLFSEKKA------GAI--E---VGNKIEADLPE---------------------- -----------------------------PPKPNP-PE---EE-TDEEK-GLRK---LFE QVA-GP---------------------------------------------DNVISAREL QHV-------------LNNVL-GR------------------------------------ -------------R---------------------------KEV------KFDGLS-LNT CISIINLM-D---VDGSGMMEFSEFKVFWDKLKKWI--------------------MLFL SYDVDRSGTMSSYELRSALN---------------------------------------- ------AA----GMKLNNRILQLLGLRFADE-KLEIDFDDYLTCIVRLENMFRIFQALDA QKK--GEVSLNMH--QEFIL-VY--MDV >T_nigroviridis_ENSTNIP00000001768 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------ELRDKYVKKKVIFEDPLFPANDSSLFYSQ----- KLPMKIEWKRPSEICENPQFIIDGANRTDICQ--GEL--GDCWLLAAIACLTVNEKLLYR VIPPDQSFTE-NYAGIFHFQFWRYGEWMDVLVDDRLPTCR-NQLVFTKSFRKNEFWSALL EK---AYAKLHGSYEALKGGNTLEAMEDFTGGVTEFFELS-E---PPKELYSIMRKALER GSLMGCSID--------------------------------------------------- IL-------SVS------------------------------------------------ -E--LETRTEQGLVKGHAYSITGLA-----E----CDEAGK----KS---SKVRLIRLRN PWG-IVLWKGPWSPN-----------STEWSTVSIADKE-NLKKQTVESSEFWMSFSDF- QRNFTKLEMCN--LTPDTLQG-DE------RH-SWTVSVNQGRWVRGSS-------AGGC RNY-P-----------DTFWTNPQYRLKLYEEDD---DSE----GGQ------------- ---------RTCTIVVALMQKGRRMQRQQGPRFLTVGFSIYK---V-----P--Q----E --MCGQ-TQHLQKDFFLYTASTAKIKSYINLREVTERFHLPPGEYVIIPTTFEPHQEGE- -FILRVFSEKQS------TSE--Q---VEDMEIQSATG---------------------- -----------------------------QRKLLE-PE---EE-TEEEK-QFRA---IFK KIS-GE---------------------------------------------DMQVCANEL KAI-------------MKNVL-DK------------------------------------ -------------H---------------------------SEI------KSEGFS-LET CRSMIALM-D---TDGTGKLNLQEFKHLWRKIQAWQ--------------------LIFK RYSKDKTCSISSFEMRNAVN---------------------------------------- ------DA----GFHLNNQLYDIIAMRYADE-RLNISFDSYICCFVRLEGMFRAFNAFDK DGD--GIIKLNVL--E-WLQ-LT--MYS >T_nigroviridis_ENSTNIP00000009062 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MPL------------QSTLSGG- -----SSGS--SKAEITQSDG-KSFEQLRQECLQKGVLFEDPDFPATDSSLFFSQ----- RVPVAIEWKRPTEICTDPRFIVGDADRTDICQ--GQL--GDCWLLAAIASLTLKKDALAQ VIPRDQEFDR-RYAGIFHFQFWQHNKWLDVVVDDRLPTVR-NNLIMLHSASNNEFWSALL EK---AYAKLHGSYESLKGGSTLEAMEDFTGGVGELYETK-K---APGDLFSIMKKALDR GSMMGCSID--------------------------------------------------- IT-------SSA------------------------------------------------ -E--SEAKLNNGLVKGHAYSITGME-----E-------VNY----RG---GTVQLIRIRN PWG-QVEWNGPWSDN-----------SREWNYVDAAEKR-RILQNSTEDGEFWMEFEDF- KANYDRVEICN--MTPDALTE-ST------KR-HWEVNLFEGSWIRGST-------AGGC RNY-I-----------DTFWTNPQFKLKLEDADD---DDD-------------------- ---------DVCSVVIALMQKNRRKLRKEGLDMETIGFAVYE---A-----P--E----H -------EDQASKDFFRYHASKARSRTYINTREVSERFTLPPGEYLLVPTTFQPHHEAD- -FLVRMFSEKKA------GAV--E---MGSTVDADLPE---------------------- -----------------------------PPPPSL-PE---EE-SDEEK-GLRR---LFD QLA-GE---------------------------------------------DKAISVREL QQM-------------LNGVL-SR------------------------------------ -------------R---------------------------KEI------KFDGLT-LST CHSIINLM-D---VDNTGMMEFQEFKVFWEKMKKWI--------------------MLFL SYDTDRSGKMSSYELRTALK---------------------------------------- ------AA----GMQLNNSLLQLIGLRFADA-NFDIDFDDYLTCIVRLENMFRIFKAMDT NKR--GRVRMNIM--Q-FLM-LS--MNV >M_domestica_ENSMODP00000011537 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MPY------------IYQGPGP- -----RAHTVPKDSRTIHSSG-KTYEELRQECLQRGILFEDRDFPANDSSLFFSD----- RPSIPFVWKRPGEIVKNPEFILGGATRTDICQ--GDL--GDCWLLAAIASLTLNEKTLAR VVPPDQNFGP-GYAGIFHFQIWQHGEWLDVVIDDRLPTFR-DRLVFLHSADHNEFWSALL EK---AYAKLSGSYEALKGGSTIEAMEDFTGGVAETFIIK-A---APKNLYEILEKAVKR GSLVGCFIE--------------------------------------------------- VK-------DSS------------------------------------------------ -E--TEAKTPFGLIKGHAYTVTGIN-----Q-------VNY----KG---QKVELIRVRN PWG-QVEWNGPWSDN-----------SPEWNFVNSSEQK-RLCHSALDDGEFWMTFKDF- KVHFDKVEICN--LTPDALEE-DT------LH-KWEVTIYQGSWVRGST-------AGGC RNY-I-----------DTFWTNPQIKLSLTEKDD---GQE-------------------- ----------ECTFIVALMQKDRRKLKKFGANLLTIGYAIYQ---ACSIQSP--A----E -------NEHLNKDFFKFHSSQARSKEYINLREVSNRFKLPPGEYILIPSTFEPHEEAN- -FCLRIFSEKKT------KYQ--D---MDETVDIALPE---------------------- -----------------------------PSKPTS-PS---QE-TKEDK-ELRS---LFE QVS-GE---------------------------------------------DMEVTAEEL RHV-------------LNTML-QK------------------------------------ -------------E---------------------------KNI------KFKKLS-LIS CKNIISLM-D---TNGSGKMEFNEFKMFWIRLKQWI--------------------NIFL QFDADKSGTMSSYELRLALK---------------------------------------- ------AA----GFQLGNYLLQLIVLRYADE-LYQLDFDDFLNCMIRLENATRVFQVLKA KDK--ECIHLNIN--E-FIC-LA--MNI >R_norvegicus_ENSRNOP00000025357 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MPY------------LHRSLRP- -----QPQPVPRDARTVHSSG-HSFEQLRQSCLQSGTLFEDADFPASNSSLFYSE----- RPQVPFVWKRPGEIVENPEFILGGATRTDICQ--GEL--GDCWLLAAIASLTLNQKALAR VVPQDQGFGS-GYAGIFHFQFWQHSEWLDVVIDDRLPTFR-DRLVFLHSADHNEFWSALL EK---AYAKLNGSYEALKGGSAIEAMEDFTGGVAENFQIR-E---APEDFYEILEKALRR GSLLGCSID--------------------------------------------------- TL-------NAS------------------------------------------------ -E--SEARTPLGLIKGHAYTVTGLD-----Q-------VNF----HG---QRIKLIRVRN PWG-QVEWNGPWSDS-----------SPEWRSMSLEEQK-RLGHTALDDGEFWMAFEDF- KTHFDKVEICN--LTPDALED-NT------LH-KWEVTIHQGSWVRGST-------AGGC RNF-L-----------DTFWTNPQIKLSLTERDE---GQE-------------------- ----------GCTFLAALMQKDRRRLKRFGANMLTIGYAIYQ---C-----P--D----K -------DGHLNRDFFRYHASLARSKTFINLREVSGRFQLPPGDYILIPSTFEPHQEAD- -FCLRIFSEKKA------VTQ--D---LDENIDIDLPE---------------------- -----------------------------LPKPTP-QE---EE-TEEER-QFRA---LFR RIA-GE---------------------------------------------DMEVSAEEL EYV-------------LNAVL-QK------------------------------------ -------------K---------------------------TAL------KFKRLS-LLS CRNIISLM-D---TSGNGKMEFEEFRVFWDKLRYWM--------------------DLFL QFDVDKSGTMSSYELRTALK---------------------------------------- ------AA----GFQLGSHLLQLIVLRYADE-NLQLDFDDYLNCLVRLENASRVFQCLSV KNK--DFIHLNIN--E-FIN-LT--MNI >H_sapiens_ENSP00000271971 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MPY------------LYRAPGP- -----QAHPVPKDARITHSSG-QSFEQMRQECLQRGTLFEDADFPASNSSLFYSE----- RPQIPFVWKRPGEIVKNPEFILGGATRTDICQ--GEL--GDCWLLAAIASLTLNQKALAR VIPQDQSFGP-GYAGIFHFQFWQHSEWLDVVIDDRLPTFR-DRLVFLHSADHNEFWSALL EK---AYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTK-E---APENFYEILEKALKR GSLLGCFID--------------------------------------------------- TR-------SAA------------------------------------------------ -E--SEARTPFGLIKGHAYSVTGID-----Q-------VSF----RG---QRIELIRIRN PWG-QVEWNGSWSDS-----------SPEWRSVGPAEQK-RLCHTALDDGEFWMAFKDF- KAHFDKVEICN--LTPDALEE-DA------IH-KWEVTVHQGSWVRGST-------AGGC RNF-L-----------DTFWTNPQIKLSLTEKDE---GQE-------------------- ----------ECSFLVALMQKDRRKLKRFGANVLTIGYAIYE---C-----P--D----K -------DEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEAD- -FCLRIFSEKKA------ITR--D---MDGNVDIDLPE---------------------- -----------------------------PPKPTP-PD---QE-TEEEQ-RFRA---LFE QVA-GE---------------------------------------------DMEVTAEEL EYV-------------LNAVL-QK------------------------------------ -------------K---------------------------KDI------KFKKLS-LIS CKNIISLM-D---TSGNGKLEFDEFKVFWDKLKQWI--------------------NLFL RFDADKSGTMSTYELRTALK---------------------------------------- ------AA----GFQLSSHLLQLIVLRYADE-ELQLDFDDFLNCLVRLENASRVFQALST KNK--EFIHLNIN--E-FIH-LT--MNI >E_caballus_ENSECAP00000013499 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MPY------------LHPAPGP- -----QEHPTPKDARITHSSG-QSFEQLRQESLQKGTLFEDADFPANSSSLFYSE----- RPQIPFVWKRPGEIVENPEFILGGATRTDICQ--GEL--GDCWLLAAIASLTLNEKALAR VVPQDQGFGP-GYAGIFHFQFWQHSEWLDVVIDDRLPTFR-DRLIFLHSADHNEFWSALL EK---AYAKLNGSYEALKGGNAIEAMEDFTGGVAETFETK-E---APENFYEILEKALKR SSLVGCSID--------------------------------------------------- IR-------NAA------------------------------------------------ -E--SEARTPFGLIKGHAYTVTGID-----Q-------VNC----RG---QKIELIRVRN PWG-HVEWNGSWSDS-----------SSEWHSVSPAEQR-RLCHTALDDGEFWMAFRDF- KAHFDKVEICN--LTPDALEE-GA------LH-KWEVMVHQGSWVRGST-------AGGC RNF-L-----------DTFWTNPQIKLSLTETDE---GQE-------------------- ----------ECTFLVALMQKDRRKLKRFGANVLTIGYAIYK---C-----P--G----K -------DEHLSKDFFRYHASQARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEAD- -FCLRIFSEKKA------ITQ--D---VDGNVDIELPE---------------------- -----------------------------PPKPML-PG---QE-TEEEQ-QFRA---LFE QVA-GE---------------------------------------------DMEVTAEKL EYV-------------LNAVL-QK------------------------------------ -------------R---------------------------KDI------KFKKLS-LIS CKNIISLM-D---TSGNGMLEFSAFKVFWDKLKKWT--------------------NLFL QFDADKSGTMSSYELRTALR---------------------------------------- ------AA----GFQLSSHLLQLIVLRYADE-ELQLGFDDFLNCMVRLENASRVFQALST KNK--EFIHLNIN--E-FII-LT--MNI >M_musculus_ENSMUSP00000090717 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MPY------------LHRSLRP- -----QPQPVPGDARTIHSSG-QSFEQLRQGCLQSGTLFEDADFPASNVSLFYSE----- RPQVPFVWKRPGEIVEKPEFILGGATRTDICQ--GEL--GDCWLLAAIASLTLNQKALTR VVPQDQGFGS-GYAGIFHFQFWQHSEWLDVVIDDRLPTFK-DRLVFLHSADHNEFWSALL EK---AYAKLNGSYEALKGGSAIEAMEDFTGGVAENFQIR-E---APEDFFEILEKALKR GSLLGCSID--------------------------------------------------- TL-------NAS------------------------------------------------ -E--SEARTSLGLIKGHAYTVTGLD-----Q-------VNF----HG---QRIKLIRVRN PWG-QVEWNGPWSDS-----------SPEWRSVDLEEQK-RLGHTALDDGEFWMAFKDF- KIHFDKVEICN--LTPDALED-SA------LH-RWEVTIHQGSWVRGST-------AGGC RNF-L-----------DTFWTNPQIKLSLTERDE---GQE-------------------- ----------GCTFLAALMQKDRRRLKRFGANMLTIGYAIYQ---C-----P--D----K -------DGHLSRDFFRYHASLARSKTFINLREVSERFQLPPGDYILIPSTFEPHQEAD- -FCLRIFSEKRA------VTR--D---LDENIDIDLPE---------------------- -----------------------------LPKPTP-QE---EE-TEEEQ-QFRA---LFQ RVA-GE---------------------------------------------DMEVSAEEL EYV-------------LNAVL-QK------------------------------------ -------------K---------------------------TAL------KFKRLS-LLS CRNIISLM-D---TSGNGKLEFEEFRVFWDKLKHWM--------------------DLFL QFDVDKSGTMSSYELRTALK---------------------------------------- ------AA----GFQLGGHLLQLIVLRYADE-DLQLDFDDYLNCLVRLENASRVFQSLSV KNK--DFIHLNIN--E-FIS-LT--MNI >T_rubripes_ENSTRUP00000006125 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------YLLFDLQFLVDRAQRESERASR- -----GSGS--SKAENTQSDG-KSFEQLRQECLQKGILFEDPDFPATDSSLYFSQ----- SVPVAIEWKRPTEICSNPKFILDDADRTDICQ--GQL--GDCWLLAAIASLTLKKDALTR VLPHDQEFDH-RYAGIFHFQFWQHNKWLDIVVDDRLPTVR-NKLIMLHSASNNEFWSALL EK---AYAKLHGSYESLKGGSTLEAMEDFTGGVGELYETK-K---SPDNLFSIMKKALDR GSMMGCSID--------------------------------------------------- IT-------SSA------------------------------------------------ -E--SEAKLNNGLVKGHAYSITGLE-----E-------VNY----RG---RTVQLIRIRN PWG-QVEWNGPWSDN-----------SREWSYIDAAEKR-RILQNSTEDGEFWMEFDDF- KANYDRVELCN--MTPDALTE-NT------KR-HWEVNTFEGSWIRGST-------AGGC RNF-I-----------DTFWTNPQFKLRLEDADD---DDD-------------------- ---------DVCSVVIALMQKNRRKLRKEGLDMETIGFAVYE---A-----P--E----S -------EEQASKDFFRYHASKARSRTYINTREVSERFTLPPGEYLLVPTTFQPHHEAD- -FLVRMFSEKKA------GAL--E---MGSTVDADLPE---------------------- -----------------------------PPPPSL-PE---EE-TDEEK-GLRR---LFE QLA-GE---------------------------------------------DQAISVREL QQM-------------LNGVL-SR------------------------------------ -------------R---------------------------KEI------KFDGLT-LST CHSIINLM-D---VDNTGMLEFQEFKVFWEKMKKWI--------------------MLFL SFDTDRSGKMSSYELRIALK---------------------------------------- ------AA----GMQLNNSLLQLIGLRFADA-NYDIDFDDYLTCIVRLENMFRIFKAMDT NKR--GRVRMNIM--Q-FLM-LS--MNV >G_gallus_ENSGALP00000031999 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPSAINAAVAQQTAAGS------VPSTTSTTTEG------------TGGGTGGI -----YSAIISRNQPIIKVKE-KTYEELHKKCLEENILYEDPDFPPNETSLFYSQ----- KVPIKFEWKRPREICENPRFIIGGANRTDICQ--GEL--GDCWFLAAIACLTLNKKLLCR VIPHDQSFIQ-NYAGIFHFQFWRYGDWVDVIIDDCLPTYN-NQLVFTKSSQRNEFWSALL EK---AYAKLHGSYEALKGGNTTEAMEDFTGGVTEFYEIK-D---APKDIYKIMKHAIAR GSLMASSIDDNLGFSYGAAPRS-DIGELIARMVKNLENAQMTYSTVDYQG-TDERPAW-- TI-------MPM------------------------------------------------ -Q--YETRMSCGLVKGHAYSVTAVE-----E-------TTY----KG---EKMRLVRLRN PWG-QVEWNGPWSDK-----------SEEWNFIDEEEKT-RLQHKIAEDGEFWISFEDF- MRHFTKLEICN--LTPDTLEA-DK------LQ-TWTVSVNEGRWVRGCS-------AGGC RNY-P-----------DTFWTNPQYRLKLLEEDD---DPE----DEE------------- ---------VICSFLVALMQKNRRKERKLGANLYTIGFAIYE---V-----PVLD----L --MHGT-KHHLQKDFFLYNASKARSKTYINMREISERFRLPPSEYVIIPSTYEPHQEGE- -FILRVFSEKRS------LSE--E---VENMIEADRPSV--STILSPIIFVSDRANSNKE LTTDEDAGKDGEKTHVDEKK----------RSSAK-AR---EK-SEEET-QFRN---IFR QIA-GD---------------------------------------------DMEINAEEL RNV-------------LNNVV-KK------------------------------------ -------------H---------------------------KDL------KTEGFE-LES CRSMIALM-D---TDGSGKINFDEFRHLWDKIKSWQ--------------------KIFK HYDADHSGTINSYEMRNAVK---------------------------------------- ------DA----GFRLNNQLYDIITMRYADK-NMNIDFDSFICCFVRLDAMFRAFHAFDK DGD--GIIKLNVL--E-WLQ-LT--MYA >C_familiaris_ENSCAFP00000017757 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MPY------------LYRAPGP- -----QKHPVPKDARITHSSG-QSFEQLRQECVQKGILFEDPDFPANSSSLFYSE----- RPQIPFVWKRPGEIVKNPEFILGGATRTDICQ--GEL--GDCWLLAAIASLTLNEKALAR VVPQDQSFGP-GYAGIFHFQFWQHSEWLDVVIDDRLPTFR-DRLIFLHSADHSEFWSALL EK---AYAKLNGSYEALKGGSTIEAMEDFTGGVAETFATK-E---APENFYEILEKALKR GSLVGCSID--------------------------------------------------- TR-------NAA------------------------------------------------ -E--SEARTPFGLIKGHAYSVTGID-----Q-------VNF----RG---QKMELIRVRN PWG-QVEWNGSWSDS-----------SSEWRSVGPAEQK-RLCHTALDDGEFWMAFRDF- KAHFDKVEICN--LTPDALEE-DA------LH-KWEVTVHQGSWVRGST-------AGGC RNF-L-----------DTFWTNPQIKLSLTEKDE---GQE-------------------- ----------DCTFLVALMQKDRRKLKRFGADMLTIGYAIYQ---S-----P--S----K -------DEHLNKDFFRYHASQARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEAD- -FCLRIFSEKKA------ITR--D---MDGDVDIDLPE---------------------- -----------------------------VSLPSH-VT---LEVTASYR-TLRF---REW LIC-NQ---------------------------------------------DMEVTAEEL EYI-------------LNAVL-QK------------------------------------ -------------K---------------------------KDF------KFKKLS-LIS CKNIISLM-D---TSGNGKLEFKEFKVFWDKLKKWT--------------------NLFH QFDTDKSGTMSSYELRTALK---------------------------------------- ------AT----GFQLGCHLLQLIVLRYADE-GLQLTFDDFLNCLVRLENASRVFQALST KDKDEEFIHLNIN--E-FIN-LT--MNI >P_troglodytes_ENSPTRP00000003544 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MPY------------LYRAPGP- -----QAHPVPKDARITHSSG-QSFEQMRQECLQRGTLFEDADFPASNSSLFYSE----- RPQIPFVWKRPGEIVKNPEFILGGATRTDICQ--GEL--GDCWLLAAIASLTLNQKALAR VIPQDQSFGP-GYAGIFHFQFWQHSEWLDVVIDDRLPTFR-DRLVFLHSADHNEFWSALL EK---AYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTR-E---APENFYEILEKALKR GSLLGCFID--------------------------------------------------- TR-------SAA------------------------------------------------ -E--SEARTPFGLIKGHAYSVTGID-----Q-------VSF----RG---QRIELIRIRN PWG-QVEWNGSWSDS-----------SSEWRSVGPAEQK-RLCHTALDDGEFWMAFKDF- KAHFDKVEICN--LTPDALEE-DA------IH-KWEVTVHQGSWVRGST-------AGGC RNF-L-----------DTFWTNPQIKLSLTEKDE---GQE-------------------- ----------ECSFLVALMQKDRRKLKRFGANVLTIGYAIYE---C-----P--D----K -------DEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEAD- -FCLRIFSEKKA------ITR--D---MDGNVDIDLPE---------------------- -----------------------------PPKPTP-PD---QE-TEEEQ-RFRA---LFE QVA-GE---------------------------------------------DMEVTAEEL EYV-------------LNAVL-QK------------------------------------ -------------K---------------------------KDI------KFKKLS-LIS CKNIISLM-D---TSGNGKLEFDEFKVFWDKLKQWI--------------------NLFL RFDADKSGTMSTYELRTALK---------------------------------------- ------AA----GFQLSSHLLQLIVLRYADE-ELQLDFDDFLNCLVRLENASRVFQALST KNK--EFIHLNIN--E-FIH-LT--MNI >T_rubripes_ENSTRUP00000046250 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MGEERAKVPVVEETSVRVLCLSEASYESDDKSDY------------PPAGTNSI -----YSAILSRNEAVKDAKRLKTFLELRDKYVKKKVIFEDPLFPANDSSLFYSH----- KPPMKIEWKRPSEICENPQFIIDGANRTDICQ--GEL--GDCWLLAAIACLTVNEKLLYR VIPPDQSFTQ-NYAGIFHFQFWRYGEWVDVLVDDRLPTCR-GQLVFTKSFRKNEFWSALL EK---AYAKLHGSYEALKGGNTLEAMEDFTGGVTEFFELS-E---PPRELYSIMRKALER GSLMGCSID--------------------------------------------------- VS-------SVS------------------------------------------------ -E--LETRTEQGLVKGHAYSIIGLT-----EVRKVCDEVA-----NK---AKVRLIRLRN PWG-IVLWKGPWCPN-----------SKEWSTISIADQE-NLKKQTVESSEFWMSFDDF- QRNFTKLEMCN--LTPDALQG-EE------RR-SWTVSVNQGRWVRGSS-------AGGC RNY-P-----------DTFWTNPQYRMKLYEEDD---DSE----GSQ------------- ---------ETCTVVVALMQKGRRMQRQQGNRFFTIGFSIYK---V-----P--L----E --MCGQ-TQHLQKDFFLYTASTAKCKTYINLREVTERFHLPPGEYVIIPTTFEPHQEGE- -FILRVFSEKQS------TSD-KQ---RSEGRFSSFVP---------------------- -----------------------------QRKLLE-PE---EE-TEEEK-QFRV---IFK KIS-GE---------------------------------------------DMQICANEL KGI-------------MKNVL-DK------------------------------------ -------------H---------------------------SEI------KTEGFS-LET CRSMIALM-D---TDGTGKLNLQEFKHMWRKIKAWQ--------------------LIFR RYTKDKTCSISSFEMRNAVN---------------------------------------- ------DA----GFHLNNQLYDIIAMRYADE-HLNINFDGYICCFVRLEGMFRAFNAFDK DGD--GIIKLNVL--E-WLQ-LT--MYS >A_carolinensis_ENSACAP00000001987 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------G-QTYKELKLECLQKGILFEDCDFPPNDASLFFSE----- KPPVPFVWKRPGEIVKDPQFIIGGATRTDICQ--GDL--GDCWLLAAIASLTLNEKTLAR VVPQDQDFGP-GYAGIFHFQFWQHNEWLDVVIDDQLPTFK-DRLVFLHSADHNEFWSALL EK---AYAKLNGSYEALKGGSTIEAMEDFTGGVAEMYEVK-K---APENFYEILEKALNR GSMVGCSID--------------------------------------------------- VS-------QIS------------------------------------------------ -E--TEARTPYGLIKGHAYSVTGIN-----E-------VNY----QG---RKVKLIRIRN PWG-QVEWNGPWSDN-----------SPEWNSISQSEKK-RLYQTALDDGEFWMKFEDF- QTHFDK-EICN--LTPDALED-NI------AH-KWAVTVHQGSWVRGAT-------AGGC RNF-I-----------ETFWTNPQFKIQLTEKDD---GKD-------------------- ----------GCTFLAALMQKDRRKLKKLGAEMLTIGYAIYE---V-FLTIP--D----E -------DEQVTKDFFRYHASKARSKTYINLREVSDRFTLPPGNYIIVPTTFEPHQEAD- -FCLRIFSENKA------LTK--E---MDGKVDINLPE---------------------- ------------------------------------VG---EE-TEEEK-QFRT---LFT QIS-GE---------------------------------------------DMEISPEEL EYV-------------LNAVL-KK------------------------------------ -------------T---------------------------NNI------KFKKIS-LLS CKNIISLM-D---SSGNGKLDFSEFKIFWDKLKKWI--------------------GIYL HFDADHSGTMSAYELRLALK---------------------------------------- ------AA----GFQLNNYLLQLIVLRYADD-QYQIEFDDFLNCLIRLE----------- ---------------------------- >M_mulatta_ENSMMUP00000016912 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MVA------------HINYSRL- -----KASGVGQHHNAHNFGN-QSFEELRAVCLRKGELFEDPLFPAEPSSLGFKDLGPNS KNVQNICWQRPKDIISNPLFIMDGISPTDVCQ--GIL--GDCWLLAAIGSLTTCPKLLYR VVPRGQSFKK-NYAGIFHFQIWQFGQWVNVVVDDRLPTKN-DKLVFVHSTERSEFWSALL EK---AYAKLSGSYEALSGGSTIEGFEDFTGGVAQSFQLQ-R---PPQNLLRLLRKAVER SSLMGCSIE--------------------------------------------------- VT-------SDS------------------------------------------------ -D--LESMTNKMLVRGHAYSVTGLQ-----D-------VHY----RG---KMETLIRVRN PWG-RIEWNGAWSDS-----------PLERKEGTEDASV--LLMG-STPTHHRMSYQDF- LNNFTLLEICN--LTPDALSG-DY------KS-YWHTTFYEGSWRRGSS-------AGGC RNH-P-----------GTFWTNPQFKISLPEGDDPEDDTE----NDA------------- ---------VVCTCLVALMQKNWRHARQQGTQLQTIGFVLYS---V-----G--A---WL --FQNIQDVPLKKEFFVKYQDHGFSEIFANSREVSSQLRLPPGEYIIIPSTFEPHRDAD- -FLLRVFTEKHS------ESW--E---LDEVNYAEQLQ---------------------- -------------------------------E--E-KV---FE-DDMDQ-DFLH---LFK IVA-GE---------------------------------------------GKEIGAHEL QRL-------------LNRMA-IK------------------------------------ -------------F---------------------------KSF------KTKGFG-LDA CRCMINLM-D---KDDSGKLGLLEFKILWKKLKKWT--------------------DIFR ECDQDHSGTLNSYEMRLAIE---------------------------------------- ------KA----GIKLNNKVTQVLVARYADD-DLIVDFDSFISCFLRLKTMFS------- ---------------------------- >P_troglodytes_ENSPTRP00000055452 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEA------------GGGNPSGI -----YSAIISRNFPIIGVKE-KTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQ----- KFPIQFVWKRPPEICENPRFIIDGANRTDICQ--GEL--GDCWFLAAIACLTLNQHLLFR VIPHDQSFIE-NYAGIFHFQFWRYGEWVDVVIDDCLPTYN-NQLVFTKSNHRNEFWSALL EK---AYAKLHGSYEALKGGNTTEAMEDFTGGVTEFFEIR-D---APSDMYKIMKKAIER GSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRG-SDERPTR-- TI-------IPV------------------------------------------------ -Q--YETRMACGLVRGHAYSVTGLD-----E-------VLF----KG---EKVKLVRLRN PWG-QVEWNGSWSDR-----------WKDWSFVDKDEKA-RLQHQVTEDGEFWMSYEDF- IYHFTKLEICN--LTADALQS-DK------LQ-TWTVSVNEGRWVRGCS-------AGGC RNF-P-----------DTFWTNPQYRLKLLEEDD---DPD----DSE------------- ---------VICSFLVALMQKNRRKDRKLGASLFTIGFAIYE---V-----P--K----E --MHGN-KQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGE- -FILRVFSEKRN------LS--------------------------PIIFVSDRANSNKE LGVDQESEEGKGKTSPDKQK--QSP----QPQPGS-SD---QE-SEEQQ-QFRN---IFK QIA-GD---------------------------------------------DMEICADEL KKV-------------LNTVV-NK------------------------------------ -------------H---------------------------KDL------KTHGFT-LES CRSMIALM-D---TDGSGKLNLQEFHHLWNKIKAWQ--------------------KIFK HYDTDQSGTINSYEMRNAVN---------------------------------------- ------DA----GFHLNNQLYDIITMRYADK-HMNIDFDSFICCFVRLEGMFRAFHAFDK DGD--GIIKLNVL--E-WLQ-LT--MYA >B_taurus_ENSBTAP00000011677 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPTVISASVAPRTGAEPMSPGPIAQAAQDKGTEA------------GGGNPSGI -----YSAIISRNFPIIGVKE-KTFEQLHKKCLEKKVLFVDPEFPPDETSLFYSQ----- KFPIQFVWKRPPEICENPRFIVGGANRTDICQ--GDL--GDCWFLAAIACLTLNKRLLFR VIPHDQSFTE-NYAGIFHFQFWRYGDWVDVVIDDCLPTYN-NQLVFTKSNHRNEFWSALL EK---AYAKLHGSYEALKGGNTTEAMEDFTGGVTEFFEIK-D---APRDMYKIMKKAIER GSLMGCSIDDGTNMTYGTSPSGLKMGELIERMVRNMDNSRLRDSDLIPEGCSDDRPTR-- MI-------VPV------------------------------------------------ -Q--FETRMACGLVKGHAYSVTGLE-----E-------ALY----KG---EKVKLVRLRN PWG-QVEWNGSWSDS-----------WKDWSYVDKDEKA-RLQHQVTEDGEFWMSYDDF- IYHFTKLEICN--LTADALES-DK------LQ-TWTVSVNEGRWVRGCS-------AGGC RNF-P-----------DTFWTNPQYRLKLLEEDD---DPD----DSE------------- ---------VICSFLVALMQKNRRKDRKLGANLFTIGFAIYE---V-----P--K----E --MHGN-KQHLQKDFFLYNASKARSRTYINMREVSERFRLPPSEYVIVPSTYEPHQEGE- -FILRVFSEKRN------LSE--E---VENTISVDRPVK--KKKNKPIIFVSDRANSNKE LGVDQETEEGKDNTSPDKQA--KSP----QLEPGN-TD---QE-SEEQR-QFRN---IFR QIA-GD---------------------------------------------DMEICADEL KNV-------------LNRVV-NK------------------------------------ -------------H---------------------------KDL------KTQGFT-LES CRSMIALM-D---TDGSGRLNLQEFHHLWKKIKTWQ--------------------KIFK HYDTDQSGTINSYEMRNAVK---------------------------------------- ------DA----GFHLNNQLYDIITMRYADK-YMNIDFDSFICCFVRLEGMFRAFNAFDK DGD--GIIKLNVL--E-WLQ-LT--MYA >M_musculus_ENSMUSP00000028749 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPTVISPTVAPRTGAEPRSPGPVPHPAQGKTTEA------------GGGHPSGI -----YSAIISRNFPIIGVKE-KTFEQLRRKCLEKKVLYLDPEFPPDETSLFYSQ----- KFPIQFVWKRPPEICENPRFIIGGANRTDICQ--GDL--GDCWFLAAIACLTLNERLLFR VIPHDQSFTE-NYAGIFHFQFWRYGDWVDVVIDDCLPTYN-NQLVFTKSNHRNEFWSALL EK---AYAKLHGSYEALKGGNTTEAMEDFTGGVTEFFEIK-D---APSDMYKIMRKAIER GSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLRDSDLDPRG-SDDRPSR-- TI-------VPV------------------------------------------------ -Q--YETRMACGLVKGHAYSVTGLE-----E-------ALF----KG---EKVKLVRLRN PWG-QVEWNGSWSDG-----------WKDWSFVDKDEKA-RLQHQVTEDGEFWMSYDDF- VYHFTKLEICN--LTADALES-DK------LQ-TWTVSVNEGRWVRGCS-------AGGC RNF-P-----------DTFWTNPQYRLKLLEEDD---DPE----DSE------------- ---------VICSFLVALMQKNRRKDRKLGANLFTIGFAIYE---V-----P--K----E --MHGN-KQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGE- -FILRVFSEKRN------LSE--E---AENTISVDRPVK--KKKNKPIIFVSDRANSNKE LGVDQEAEEGKDKAGPEKRG--ETP----QPRPGH-TD---QE-SEEQQ-QFRN---IFR QIA-GD---------------------------------------------DMEICADEL KNV-------------LNTVV-NK------------------------------------ -------------H---------------------------KDL------KTQGFT-LES CRSMIALM-D---TDGSGRLNLQEFHHLWKKIKAWQ--------------------KIFK HYDTDHSGTINSYEMRNAVN---------------------------------------- ------DA----GFHLNSQLYDIITMRYADK-HMNIDFDSFICCFVRLEGMFRAFNAFDK DGD--GIIKLNVL--E-WLQ-LT--MYA >P_pygmaeus_ENSPPYP00000000120 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MPY------------LYRAPGP- -----QAHPVPKDARTTHSSG-QSFEQMRQECLQRGTLFEDADFPASNSSLFYSE----- RPQIPFVWKRPGEIVKNPEFILGGATRTDICQ--GEL--GDCWLLAAFA-LTL-QKALAR VIPQDQSFGP-GYAGIFHFQFWQHSEWLDVVIDDRLPTFR-DRLVFLHSADHNEFWSALL EK---AYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTK-E---APENFYEILEKALKR GSLLGCFID--------------------------------------------------- TR-------SAA------------------------------------------------ -E--SEARTPFGLIKGHAYSVTGID-----Q-------VNF----RG---QRIELIRVRN PWG-QVEWNGSWSDS-----------SPEWRSVGPAEQK-RLCHTALDDGEFWMAFKDF- KAHFDKVEICN--LTPDALEE-DA------IH-KWEVTVHQGSWVRGST-------AGGC RNF-L-----------DTFWTNPQIKLSLTEKDE---GQE-------------------- ----------ECSFLVALMQKDRRKLKRFGANVLTIGYAIYE---C-----P--D----K -------DEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEAD- -FCLRIFSEKKA------ITR--D---MDGNVDIDLPE---------------------- -----------------------------PPKPTP-PD---QE-TEEEQ-QFRA---LFK QVA-GE---------------------------------------------DMEVTAEEL EYV-------------LNAVL-QK------------------------------------ -------------K---------------------------KDI------KFKKLS-LIS CKNIVSLM-D---TSGNGKLEFDEFKVFWDKLKQWI--------------------NLFL RFDADKSGTMSTYELRTALK---------------------------------------- ------AA----GFQLSSHLLQLIVLRYADE-ELQLDFDDFLNCLVRLENASRVFQALST KSK--EFIHLNIN--E------------ >H_sapiens_ENSP00000326281 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEA------------GGGNPSGI -----YSAIISRNFPIIGVKE-KTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQ----- KFPIQFVWKRPPEICENPRFIIDGANRTDICQ--GEL--GDCWFLAAIACLTLNQHLLFR VIPHDQSFIE-NYAGIFHFQFWRYGEWVDVVIDDCLPTYN-NQLVFTKSNHRNEFWSALL EK---AYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIR-D---APSDMYKIMKKAIER GSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRG-SDERPTR-- TI-------IPV------------------------------------------------ -Q--YETRMACGLVRGHAYSVTGLD-----E-------VPF----KG---EKVKLVRLRN PWG-QVEWNGSWSDR-----------WKDWSFVDKDEKA-RLQHQVTEDGEFWMSYEDF- IYHFTKLEICN--LTADALQS-DK------LQ-TWTVSVNEGRWVRGCS-------AGGC RNF-P-----------DTFWTNPQYRLKLLEEDD---DPD----DSE------------- ---------VICSFLVALMQKNRRKDRKLGASLFTIGFAIYE---V-----P--K----E --MHGN-KQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGE- -FILRVFSEKRN------LSE--E---VENTISVDRPVR--KETYKPIIFVSDRANSNKE LGVDQESEEGKGKTSPDKQK--QSP----QPQPGS-SD---QE-SEEQQ-QFRN---IFK QIA-GD---------------------------------------------DMEICADEL KKV-------------LNTVV-NK------------------------------------ -------------H---------------------------KDL------KTHGFT-LES CRSMIALM-D---TDGSGKLNLQEFHHLWNKIKAWQ--------------------KIFK HYDTDQSGTINSYEMRNAVN---------------------------------------- ------DA----GFHLNNQLYDIITMRYADK-HMNIDFDSFICCFVRLEGMFRAFHAFDK DGD--GIIKLNVL--E-WLQ-LT--MYA >R_norvegicus_ENSRNOP00000046272 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPTVISPTVAPRTGAEPRSPGPVPHPAQGKTTEA------------GGGHPGGI -----YSAIISRNFPIIGVKE-KTFEQLHKKCLEKKVLYLDPEFPPDETSLFYSQ----- KFPIQFVWKRPPEICENPRFIIGGANRTDICQ--GDL--GDCWFLAAIACLTLNERLLFR VIPHDQSFTE-NYAGIFHFQFWRYGDWVDVVIDDCLPTYN-NQLVFTKSNHRNEFWSALL EK---AYAKLHGSYEALKGGNTTEAMEDFTGGVTEFFEIK-D---APSDMYKIMRKAIER GSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLRDSDLDPRA-SDDRPSR-- TI-------VPV------------------------------------------------ -Q--YETRMACGLVKGHAYSVTGLE-----E-------ALF----KG---EKVKLVRLRN PWG-QVEWNGSWSDG-----------WKDWSFVDKDEKA-RLQHQVTEDGEFWMSYDDF- VYHFTKLEICN--LTADALES-DK------LQ-TWTVSVNEGRWVRGCS-------AGGC RNF-P-----------DTFWTNPQYRLKLLEEDD---DPD----DSE------------- ---------VICSFLVALMQKNRRKDRKLGANLFTIGFAIYE---V-----P--K----E --MHGN-KQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGE- -FILRVFSEKRN------LSE--E---AENTISVDRPVV--SERTEPIIFVSDRANSNKE LGVDQEAEEGKDKTGPDKQG--ESP----QPRPGH-TD---QE-SEEQQ-QFRN---IFR QIA-GD---------------------------------------------DMEICADEL KNV-------------LNTVV-NK------------------------------------ -------------H---------------------------KDL------KTQGFT-LES CRSMIALM-D---TDGSGRLNLQEFHHLWKKIKAWQ--------------------KIFK HYDTDHSGTINSYEMRNAVN---------------------------------------- ------DA----GFHLNSQLYDIITMRYADK-HMNIDFDSFICCFVRLEGMFRAFHAFDK DGD--GIIKLNVL--E-WLQ-LT--MYA >M_mulatta_ENSMMUP00000002049 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEA------------GGGNASGI -----YSAIISRNFPIIGVKE-KTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQ----- KFPIQFIWKRPPEICENPRFIIDGANRTDICQ--GDL--GDCWFLAAIACLTLNQRLLFR VIPHDQSFIE-NYAGIFHFQFWRYGEWVDVVIDDCLPTYN-NQLVFTKSNHRNEFWSALL EK---AYAKLHGSYEALKGGNTTEAMEDFTGGVTEFFEIR-D---APSDMHKIMKKAIER GSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLFRDSDLDPRA-SVERPTR-- TI-------VPV------------------------------------------------ -Q--YETRMACGLVRGHAYSVTGLD-----E-------VLF----KG---EKVKLVRLRN PWG-QVEWNGSWSDG-----------WKDWSFVDKDEKA-RLQHQVTEDGEFWMSYEDF- IYHFTKLEICN--LTADALQS-DK------LQ-TWTVSVNEGRWVRGCS-------AGGC RNF-P-----------DTFWTNPQYRLKLLEEDD---DPD----DSE------------- ---------VICSFLVALMQKNRRKDRKLGANLFTIGFAIYE---V-----P--K----E --MHGN-RQHLQKDFFLYNASRARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGE- -FILRVFSEKRN------LSE--E---VENTISVDRPVV--SEAASPIIFVSDRANSNKE LGVDQESEEGKGKTSPDKQE--QSP----QPQPGS-SD---QE-SEEQQ-QFRN---IFK QIA-GD---------------------------------------------DMEICADEL KKV-------------LNTVV-NK------------------------------------ -------------H---------------------------KDL------KTHGFT-LES CRSMIALM-D---TDGSGKLNLQEFHHLWNKIKAWQ--------------------KIFK HYDTDQSGTINSYEMRNAVN---------------------------------------- ------DA----GFHLNNQLYDIITMRYADK-HMNIDFDSFICCFVRLEGMFRAFHAFDK DGD--GIIKLNVL--E-WLQ-LT--MYA >X_tropicalis_ENSXETP00000050369 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MPY------------IYQDPSL- -----KESIAQQTPRSIHSSG-KTYEQLKNDCLRKGVLFEDVDFPANDSSLFYSE----- KPSVPFVWKRPKEMVADPEFILGGASRTDVCQ--GDL--GDCWLLAAIASLTLNDKILYR VVPPDQSFST-GYAGIFHFQFWQHNEWLDVVIDDRLPTFR-NRLVFVHSADLNEFWSALL EK---AYAKLNGSYEALKGGSTLEAMEDFTGGVTETYEIR-S---APANLFDILDKAIKK GSMLGCSID--------------------------------------------------- IT-------SSA------------------------------------------------ -E--TEAKTPQGLVKGHAYSITGAD-----V-------VNF----KG---QKVKLIRIRN PWG-QVEWNGAWSDN-----------SSEWNIIGAAEKN-RLSQASLDDGEFWMDFEDF- KRHFDKLEICN--LTPDSLDD-DA------KH-KWEVTVHEGSWIRGST-------AGGC RNF-L-----------ETFWSNPQIKLSLTEQDD---GQK-------------------- ----------ECTFIAALMQKNRRKLRKTGADLLTIGYTIYQ---C-----P--G----S -------ESILSKDFFKFNPSKARSKTYVNLREISQRFKLPPGDYMFIPTTFEPHQEAD- -FCLRIFSEKKA------DIK--E---MDGEVNIDLPD---------------------- -----------------------------PPAPTP-PH---KE-TEEER-QFRT---LFE QIS-GQ---------------------------------------------DLEVSAEEL QYV-------------LNAVL-RR------------------------------------ -------------T---------------------------KNI------KFKEMS-LLS CNNIISLM-D---ASGNGKLGFDEFKIFWDKLKTWI--------------------GIFM QYDLDKSGTMSSYELRLALK---------------------------------------- ------SA----GFHLNNIVLQLI------------------------------------ ---------------------------- >T_guttata_ENSTGUP00000011447 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPTAINAVVAQQTAAGS------VPSTAAGTTEG------------AGGGTGGI -----YSAIISRNQPIIHVKE-KTYEELHKKCLEKNILYEDPDFPPNESSLFYSQ----- KSPVKFEWKRPREICENPRFIIGGANRTDICQ--GEL--GNCWFLAAIACLTLNKKLLCR VIPHDQSFIQ-NYAGIFHFQFWRYGNWVDVVIDDCLPTYN-NQLVFTKSSQRNEFWSALL EK---AYAKLHGSYEALKGGNTTEAMEDFTGGVTEFYEIK-D---APKDIYKIMKHAIDR GSLMASSIDDDLGFSYGSAPRS-NIGELIARMVKNQENAQMTQSSVDYQG-MEERPAW-- TI-------VPM------------------------------------------------ -Q--YETRMSCGLVKGHAYSVTAVE-----E-------VLF----KG---EKIRLVRLRN PWG-QVEWNGAWSDK-----------SEEWDSVNEAEKI-RLQHKVVEDGEFWISFQDF- MRHFTKLEICN--LTPDTLEV-DK------FQ-TWTVSVNEGRWVRGCS-------AGGC RNF-P-----------DTFWTNPQYRLKLLEEDD---DPE----DEE------------- ---------VICSFLVALMQKNRRKERKLGANLYTIGFAIYE---V-----T--D----S --MHGT-KHHLQKDFFLYNASKARSKTYINMREISERFRLPPSEYVIIPSTYDPHQEGE- -FILRVFSEKRS------LSE--E---EENRVANSEVIH--SRHVAPIIFVSDRANSNKE LTPDENAGKDGEKTQTDEKK--TVP----SRSSTK-AH---EE-TEEQK-QFRN---IFR QIA-GD---------------------------------------------DMEINAEEL RNV-------------LNNVV-KK------------------------------------ -------------H---------------------------KDL------RSEGFE-LES CRSMIALM-D---TDGSGKINFDEFRHLWDKIKSWQ--------------------KIFK RYDTDHSGTINSYEMRNAVK---------------------------------------- ------DA----GFRLNNQLYDIITMRYADK-NMNIDFDSFICCFVRLDAMFRAFHAFDK DGD--GIIKLNVL--E-WLQ-LT--LYA >E_caballus_ENSECAP00000010182 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPTVISASVASRTGAEPMSPGPVAHPAQGSTTES------------GGGNPSGN -----YSAIISRNFPIIGVKE-KTFEKLHKKCLEKNVLYVDPEFPPDETSLFYSQ----- KFPIQFVWKRPPEICKNPRFIIGGANRTDICQ--GDL--GDCWFLAAIACLTLNERLLFR VIPHDQSFTE-NYAGIFHFQFWRYGDWVDVVIDDCLPTYN-NQLVFTKSNHRNEFWSALL EK---AYAKLHGSYEALKGGNTTEAMEDFTGGVTEFFEIK-E---APRDMYKIMKKAIER GSLMGCSIDDGTNMTYGTSPSGLKMGDLIARMVRNMDNSRLRDSDLIPRD-SDDRPTR-- TI-------VPV------------------------------------------------ -Q--YETRMACGLVRGHAYSVIGLE-----E-------AWF----KN---EKVKLVRLRN PWG-QVEWNGSWSDG-----------WKDWSFVDKEEKA-RLQHQVTEDGEFWMSYDDF- IYHFTKLEICN--LTADALES-DK------LQ-TWTVSVNEGRWVRGCS-------AGGC RNF-P-----------DTFWTNPQYRLKLLEEDD---DPE----DSE------------- ---------VICSFLVALMQKNRRKNRKLGANLFTIGFAIYE---V-----P--K----E --MHGN-RQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGE- -FILRVFSEKRN------LSE--E---VENTISVDRPVK--KKKTKPIIFVSDRANSNKE LGVDQESEEGKDKTSPDKQE--RSP----QPQPGI-TD---QE-SEEQQ-QFYN---IFR QIA-GD---------------------------------------------DMEISADEL KNI-------------LNTVV-NR------------------------------------ -------------H---------------------------KDL------KTQGFT-LES CRSMIALM-D---TDGSGRLNLQEFHHLWNKIKTWQ--------------------KIFK HYDTDQSGTINSYEMRNAVN---------------------------------------- ------DA----GFHLNRQLYDIITMRYADK-HMNIDFDSFICCFVRLEGMFRAFHAFDK DGD--GIIKLNVL--E-WLQ-LT--MYA >C_familiaris_ENSCAFP00000015829 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPTVISASVAPRTRAEPRSPGPIPHPDQGRTTEA------------GGANPSGI -----YSAIISRNFPIIGVKE-KTFEQLRKKCLDKKVLYLDPEFPPDETSLFYSQ----- KFPIQFIWKRPPEICENPRFIIGGANRTDICQ--GDL--GDCWFLAAIACLTLNERLLFR VIPHDQSFTE-NYAGIFHFQFWRYGDWVDVVIDDCLPTYN-NQLVFTKSNHRNEFWSALL EK---AYAKLHGSYEALKGGNTTEAMEDFTGGVTEFFEIK-D---APRDMYKIMKKAIER GSLMGCSIDDGTNMTYGTSPSGLKMGELIARMVRNMDNSQLRDSDLVPRG-SDDRPTR-- TI-------VPV------------------------------------------------ -Q--YETRMACGLVKGHAYSVTGLE-----E-------ALF----KG---EKVKLVRLRN PWG-QVEWNGSWSDG-----------WKDWSFVDKAEKA-RLQHQVTEDGEFWMSYDDF- IYHFTKLEICN--LTADALES-DK------LQ-SWTVSVNEGRWVRGCS-------AGGC RNF-PGGT--------DTFWTNPQYRLKLLEEDD---DPD----DSE------------- ---------VICSFLVALMQKNRRKDRKLGANLFTIGFAIYE---V-----P--K----E --MHGN-KQHLQKDFFLYNASKARSKTYINIREVSERFRLPPSEYVIVPSTYEPHQEGE- -FILRVFSEKRN------LSE--E---VENTISVDRPVK--KKKAKPIIFVSDRANSNKE LGVDQESEEGKDKTSPDKPE--KSP----QPRPGN-TD---QE-SEEQL-QFRN---IFR QIA-GD---------------------------------------------DMEVCADEL KNI-------------LNMVV-NK------------------------------------ -------------N---------------------------KDL------KTQGFT-LES CRSMIALL-D---TDGSGRLNLQEFHHLWKKIKAWQ--------------------KIFK HYDTDQSGTINSYEMRNAVN---------------------------------------- ------DA----GFHLNSQLYDIITMRYADK-HMNIDFDSFICCFVRLEGMFRAFNAFDK DGD--GIIKLNVL--E-WLQ-LT--MYA >P_pygmaeus_ENSPPYP00000007244 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEA------------GGGNSSGI -----YSAIISRNFPIIGVKE-KTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQ----- KFPIQFVWKRPPEICKNPRFIIDGANRTDICQ--GEL--GDCWFLAAIACLTLNQHLLFR VIPHDQSFIE-NYAGIFHFQFWRYGEWVDVVIDDCLPTYN-NQLVFTKSNHRNEFWSALL EK---AYAKLHGSYEALKGGNTTEAMEDFTGGVTEFFEIR-D---APSDMYKIMKKAIER GSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRG-SDERPTR-- TI-------IPF------------------------------------------------ -Q--YETRMACGLVRGHAYSVTGLD-----E-------VLF----KG---EKVKLVRLRN PWG-QVEWNGSWSDR-----------WKDWSFVDKDEKA-RLQHQVTEDGEFWMSYEDF- IYHFTKLEICN--LTADALQS-DK------LQ-TWTVSVNEGRWVRGCS-------AGGC RNF-P-----------DTFWTNPQYRLKLLEEDD---DPD----DSE------------- ---------VICSFLVALMQKNRRKDRKLGASLFTIGFAIYE---V-----P--K----E --MHGN-KQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGE- -FILRVFSEKRN------LSE--E---VENTISVDRPVR--KETYKPIIFVSDRANSNKE LGVDQESEEGKGKTSPDKQK--QSP----QPQPGS-SD---QE-SEEQQ-QFWN---IFK QIA-GD---------------------------------------------DMEICADEL KKV-------------LNTVV-NK------------------------------------ -------------H---------------------------KDL------KTHGFT-LES CRSMIALM-D---TDGSGKLNLQEFHHLWNKIKAWQ--------------------KIFK HYDTDQSGTINSYEMRNAVN---------------------------------------- ------DA----GFHLNNQLYDIITMRYADK-HMNIDFDSFICCFVRLEGMFRAFHAFDK DGD--GIIKLNVL--E-WLQ-LT--MYA >A_carolinensis_ENSACAP00000015362 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------TAE------------TGGGAGGI -----YSAILSRNQPIIGAKE-KTFHELHKKCLEKKILYEDPDFPANESSLFYSQ----- KLPVKFEWKRPPEICENPRFIIGGANRTDICQ--GEL--GDCWFLAAIACLTLNEKLLFR VIPHDQTFIK-DYAGIFHFQFWRYGSWVEVIIDDRLPTYG-KQLVFTKSSQQNEFWSALL EK---AYAKLHGSYEALKGGNTTEAMEDFTGGVTEFYEIK-D---APKDIYKIMKHAIER GSLMASSIEDDAGIIYGT-PTT-NIGLLINRMLNNMNFKTENDST---PP-VEEKISQ-- AI-------APV------------------------------------------------ -V--FERRMANGLVLSHAYSVTGVE-----E-------ITF----KR---EKLKLIRLRN PWG-QVEWNGAWSDS-----------SDEWNVIDGAEKT-RLQHKVSEDGEFWISLQDF- LRYFTKLEICN--ITPDALEG-DK------LQ-TWTVSVTEGRWVRGCT-------AGGC RNY-P-----------DTFWTNPQYRLRLLEEDD---DPE----DSE------------- ---------VVCSFLVALMQKNRRKERRLGANLLTIGFAIYE---V-----T--E----R --MQGN-NMHLQRDFFLYNASKVKCKMYINMREVAERFRLPPNEYVIIPSTFEPHQEGE- -FLLRVFSEKIS------LSE--E---VENKIAVGQISV--TMRQSPIIFVSDRANKNKD PKGGEGHKKDKEKTITDKKK--KAD----EPSQRD-SN---KE-TEEDK-QFRN---IFR QIA-GD---------------------------------------------DMEISADEL RNV-------------LNNVL-KK------------------------------------ -------------H---------------------------KEL------KTEGFA-LES CRSMIALM-D---TDGSGKINLEEFQHLWDKIKSWQ--------------------KIFK HYDTDHSGTINSYEMRNAVK---------------------------------------- ------DA----GFQLNNQLYDIITMRYADR-NMNIEFDSFICCFVRLEGMFRAFNAFDK DGD--GIIKLNVL--E-WLQ-LT--MYA >G_gorilla_ENSGGOP00000007591 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------MSEEIITPV-YCTGVSA------------QVQKQRA- -----RELGLGRHENAIKYLG-QDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNS SKTYGIKWKRPTELLSNPQFIVDGATRTDICQ--GAL--GDCWLLAAIASLTLNDTLLHR VVPHGQSFQN-GYAGIFHFQLWQFGEWVDVVVDDLLPIKD-GKLVFVHSAEGNEFWSALL EK---AYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELR-K---APSDLYQIILKALER GSLLGCSID--------------------------------------------------- XX-------XXX------------------------------------------------ -X--XXXXXXXXXXXXXXXXXXXXX-----X-------XXX----XX---XXXXXXXXXX XXX-XXXXXXXXXXX-----------XXXXXXXXXXXXX-XXXXX-XXXXXXXXXXXXX- XXXXXXXXXXX--XXXXXXXX-XX------XX-XXXXXXXXXXXXXXXX-------XXXX XXX-X-----------XTFWVNPQFKIRLDETDD---PDDYG--DRE------------- ---------SGCSFVLALMQKHRRRERRFGRDMETIGFAVYE---V-----S--H----Q --LVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGD- -FVLRFFSEKSA------GTA--E---LDDQIQANLPD---------------------- -------------------------------E--Q-VL---SE-EEIDE-NFKA---LFR QLA-GE---------------------------------------------DMEISVKEL RTI-------------LNRII-SK------------------------------------ -------------H---------------------------KDL------RTKGFS-LES CRSMVNLM-D---RDGNGKLGLVEFNILWNRIRNYL--------------------SIFR KFDLDKSGSMSAYEMRMAIE---------------------------------------- ------SA----GFKLNKKLYELIITRYSEP-DLAVDFDNFVCCLVRLETMFRFFKTLDT DLD--GVVTFDLF--K-WLQ-LT--MFA >G_aculeatus_ENSGACP00000012988 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------AEEKADY------------PSAGTNSI -----YSAILSRNEAVKDAKRLKTFLELRDKYVKKNVVFEDPLFPANDSSLFYSH----- KPAMKFEWKRPSEICENPQFIIDGAKRTDICQ--GEL--GDCWLLAAIACLTVNEKLLYR VIPPDQSFTD-NYAGIFHFQFWRYGEWIDVIVDDRIPTCN-NHLVFTKSFRKNEFWSALL EK---AYAKLHGSYEALKGGNTLEAMEDFTGGVTEFFDLP-E---APKELYSIMRKALER GSLMGCSIDVGVDGSAQKTESFSIFLGRIRKTVFNCRIQ------------NNNLCSIRQ AL-------SAT------------------------------------------------ -E--QETRTDQGLVRGHAYSIIGLA-----E----CDGVE-----KD---TTIRLIRLRN PWG-WVLWKGPWSAN-----------STEWSTISIADKD-NLIKQTVQESEFWMSFADF- TRNFTKLEMCN--LTPDALGC-DE------RQ-SWTVSVNEGRWVRGSS-------AGGC RNF-P-----------QTFWTNPQYRLQLYEDDD---DPE----DGQ------------- ---------AACTVVVALMQKGRRMQRHQGAKFLTIGFSIYE---V-----P--K----E --MCGQ-NQHLQKDFFLYTASKAKCKTYINLREVTERVHLPQGEYAIIPTTFEPHQDGE- -FILRVFSEKKS------TSE--E---VEDTIGSEKTQQDRKKKEKPIVFVSDRARANKE IEHDGIEGEKKTKKKP-------------KRKLLQ-PE---EE-TEEEK-HFRA---IYQ KVA-GE---------------------------------------------DMQICANEL RTI-------------MRNVL-AK------------------------------------ -------------H---------------------------NEM------KTEGFS-LET CRSMIALM-D---TDGTGKLNLQEFKHLWKKIKEWQ--------------------LIFR RYDENKTGCVSSFEMRNAVN---------------------------------------- ------DAAPHEGFHLNKQLYDIIAMRYADE-HLNIDFDSYICCFVRLEGMFRAFNAFDK DGD--GIIKLNVL--E-WLQ-LT--VYS >O_anatinus_ENSOANP00000021667 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MPP-----------PLGQTPGP- -----REPHLGQV--SPGPPG-RTFEELRDRCLRRGVLFEDPDFPADDSSLFFSE----- MPPIPFAWKRPGEIARNPEFVSDGATRTDICQ--GEL--GDCWLLAAIASLTLNPRVLAR VVPPQQSFGP-DYAGIFHFQLWQHGQWLDVVIDDRLPTFK-DRLVFLHSADHNEFWSALL EK---AYVKLNGSYEALKGGSTIEAMEDFTGGVAETLDVK-A---ISQGLSEILRKALDR GSLVACSIE--------------------------------------------------- AR-------NAS------------------------------------------------ -D--SEARTPFGLVKGHAYSVTGTD-----Q-------VTF----RG---RRVELVRVRN PWG-QVEWNGPWSDD-----------SSEWRSVDPSEKK-RLYHTALDDGEFWMPFADF- EAHFDKVEICN--LTPDALEG-GT------LL-QWEVAVHHGSWVKGAT-------AGGC RNF-L-----------DTFWTNPQIKLSLSKEDG---GKE-------------------- ----------DCTLVVALMQKNRRKLKKFGANMLTIGYAIYQ---C-----P--G----Q -------DGHLGRDFFRCHASQARSKTYVNLREVSGRFKLPPGEYVLVPSTFEPHQEAD- -FCLRIFSEKAA------VTQ--D---LDGQVNVELPE---------------------- -----------------------------PLKPTS-RQ---QE-TEEER-QFRI---LFE KVA-DK---------------------------------------------DLQISAEEL QEI-------------LNAVL-RN------------------------------------ -------------T---------------------------KNI------QFKKLS-LVS CRNIISLM-D---TNGSGKLELDEFKAFWARLKAWT--------------------NIFF QFDGDKSGTMSSYELRGALK---------------------------------------- ------AA----GFQLNNNLLQLLVLRYADE-RLQVDFDDFLNCLVRLENTSRVFQALKA TDS--EFLSLSVG--E-FIL-LA--MNI >D_rerio_ENSDARP00000032267 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KDFQELRDKYVRKKVLFEDPLFPAQDSSLFYSE----- KFPLKLEWKRPMEICKNPQFILGGANRTDICQ--GDL--GDCWLLAAIACLTLNDVILKR VVPHDQSFTE-NYAGIFHFQFWRYGEWVDVVIDDRLPTYK-NKLVFTRSGQNNEFWSALM EK---AYAKLHGSYEALKGGNSLEAMEDFTGGVTEFYEIT-E---APKELYNIMRKALKR GSLMGCAID--------------------------------------------------- TL-------VPT------------------------------------------------ -A--QRTKTASGLVRGHAYSVTGVE-----Q-------GKR----KDGKDLMIRLVRVRD PWG-VAP---PPACK-----------SNDWVELAKTEQD-KQRLQPGEQGEFWMCFEEF- QKNFTKLEICN--LTPDTLED-DQ------MF-KWNVTVHEGRWVKGCS-------AGGC RNF-P-----------DTYWTNPQFRLVLLEAD-----------AKE------------- ---------KTCTVVVALMQKGRRVERCSGATLHNIGFAIYE---V-----P--K----E --MKGNQQQQLSKDFFLYNASTARSKSYVNIREVTERFCLKPGEYVIIPSTFDPHKESE- -FLLRVFSENRS------TSK--V---IDAEIEAEPMPF--------------------- ------------------------------------EE---EE-TEEEK-QFRA---IFQ QIA-GDVSANMKFILNLSH--------------------------------DMEINANEL RTV-------------LNRVV-AK------------------------------------ -------------H---------------------------KEL------KTEGFS-LES CRSMIALL-D---TDGTGHLNLQEFKHLWNKIKQWK--------------------LVFT RFDTDKSSTISSFEMRNALT---------------------------------------- ------EA----GFQLNNQLYDIICMRYANE-HMELDFDSYISCLVRLEGMFRAFRAFDK DGD--GLIKLNVF--E-WLQ-LT--MYA >O_latipes_ENSORLP00000015525 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------I -----YSAILSRNEAVKDAKRLKTFLELRDKYVKKKVLFEDPLFPANDSSLFYSH----- KPSMKIEWKRPTEICENPQFIIDGANRTDICQ--GEL--GDCWLLAAIACLTLSEKLLYR VIPPEQSFTE-NYAGIFHFQFWRYGEWIDIVVDDRIPTCN-NLLVFTKSFRENEFWSALL EK---AYAKLHGSYEALKGGNTLDAMEDFTGGVTELFELS-E---APKGLFIIMKKALER GSLMGCSIDVSGQEKCPGKSNNASNDEMWQQRHNNIENKMLSC-----------LCIVHQ VT-------TAN------------------------------------------------ -D--IESRTNQGLVRGHAYSIIALE-----E----CDQVS-----ED---GKIRLIRLRN PWG-WVLWKGPWSVN-----------SKEWSTVSTADRD-NLKKQTLEMSEFWMSFDDF- KKNFTKLEMCN--LTPDALTG-DE------RQ-SWTVSINEGRWVRGSS-------AGGC RNF-P-----------DTFWTNPQYRLRLYEED----DPE----EEQ------------- ---------VLCTVVVALMQKGRRMQRHAGAKFLTIGFSIYE---V-----P--K----E --LQGQ-NQHLQKDFFLYNASKAKCKAYINLREVTERFRLPPGEYVILPTTFKAHEEGE- -FLLRVFSENKS------TSE--E---AETSIDKIEVPYPNHPTHQPIVFVSDRARTNKE IEHEGIRGEKKKKPKKTLTR--IMG----KRKPLQ-AV---EE-TEEEK-QFRV---IYQ KIA-GE---------------------------------------------DMEICASEL MAI-------------MKNVL-SK------------------------------------ -------------H---------------------------SEI------KSDGFS-LET CRSMIALM-D---TDGSGKLNLQEFKHLWKKIKEWQ--------------------LIFK RYDKDGKCSISSFEMRNAVN---------------------------------------- ------DA----GFNLNKQLYDIIAMRYADK-HLNIDFDSYICCFVRLEGMFRAFNAFDK DGD--GIIKLNVL--E-WLQ-LT--MYS >M_domestica_ENSMODP00000022330 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPTVIKASVAQPTRAGPLSPGLIPPPVRTPTTET------------GGLNTGGI -----YSAIISRNFPIIGVKE-KTFEQLHKKCLEKKVLYLDPDFPPDETSLFYSQ----- KFPIQFVWKRPPEICENPRFIIGGANRTDICQ--GDL--GDCWFLAAIACLTLNERLLFR VIPHDQTFTE-NYAGIFHFQFWRYGDWVDVVIDDCLPTYN-NQLVFTKSNHRNEFWSALL EK---AYAKLHGSYEALKGGNTTEAMEDFTGGVTEFFEIR-D---APRDMYKIMKKAIER GSLMGCSIDDGTNMTYGTSP-GCSMRELIDRMVKNLDRSHLRDSDLDPRG-TDDRPTR-- YL-------APF------------------------------------------------ -G--H-------FINNCSSIDCFLS-----K-------TTF----KG---EKVKLVRLRN PWG-QVEWNGSWSDG-----------WKDWVLIDKEEKS-RLQHQVTEDGEFWMSYEDF- MYNFTKLEICN--LTADALES-DK------LQ-TWTVSVNEGRWVRGCS-------AGGC RNF-P-----------DTFWTNPQYRLKLLEEDD---DPE----DNE------------- ---------VVCSFLVALMQKNRRKDRKLGANLFTIGFAIYE---V-----P--K----E --MHGN-KQHLQKDFFLYNASKARSKTYINMREVSERFRLPPSEYVIVPSTYDPHQEGE- -FILRVFSEKRN------LSE--D---VENTIAVDHPVK--KKKNKPIIFVSDRANSNKE LGVDHESQEGKDKPEKPTQRCLTSPLVPLQPTSGN-TD---RE-TEEQV-QFKN---IFR QIA-GD---------------------------------------------DMEICADEL KNV-------------LNTVV-NK------------------------------------ -------------H---------------------------KDL------KIEGFT-LES CRSMIALM-D---TDGSGRLNLQEFHHLWKKIKSWQ--------------------KIFK HYDTDHSGTINSYEMRNAVN---------------------------------------- ------DA----GFHLNSQLYDIITMRYADK-HMNINFDSFICCFVRLEGMFRAFQAFDK DGD--GIIKLNVL--E-WLQ-LT--MYA >P_troglodytes_ENSPTRP00000058028 MLYSPGPSLL-----------------ESAESL--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------DGSQEDKPR-GSCAEPTFTDTGMVA------------HINHSRL- -----KAKGVGQHDNAQNFGN-QSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNS KNVQNISWQRPKDIISNPLFIMDGISPTDICQ--GIL--GDCWLLAAIGSLTTCPKLLYR VVPR-QSFKK-NYAGIFHFQIWQFGQWVNVVVDDRLPTKN-DKLVFVHSTERSEFWSALL EK---AYAKLSGSYEALSGGSTMEGLEDFTGGVAQSFQLQ-R---PPQNLLRLLRKAVER SSLMGCSIE--------------------------------------------------- VT-------SDS------------------------------------------------ -E--LESMTDKMLVRGHAYSVTGLQ-----D-------VHY----RG---KMETLIRIRN PWG-RIEWNGAWSDS-----------AREWEEVASDIQM-QLLHK-TEDGEF-MSYQD-- LNNFTLLEICN--LTPDTLSG-DY------KS-YWHTTFYEGSWRRGSS-------AGGC RNH-P-----------GTFWTNPQFKISLPEGDDPEDDAE----GNV------------- ---------VVCTCLVALMQKNWRHARQQGAQLQTIGFVLYS---V-----P--K----E --FQNIQDVHLKKEFFTKYQDHGFSEIFANSREVSSQLRLPPGEYIIIPSTFEPHRDAD- -FLLRVFTEKHS------ESC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------KLGLLEFKILWKKLKKWM--------------------DIFR ECDQDHSGTLNSYEMRLAIE---------------------------------------- ------KA----GIKLNNKVMQVLVARYADD-DLIIDFDSFISCFLRLKTMFTFFLTMDP KNT--GHICLNLE--Q-WLQ-MT--MWG >X_tropicalis_ENSXETP00000006057 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------YLG-QDYHKLVQECLQQGRLFEDPHFPADAKSLGYNELGPWS AVTRGIQWRRPQEICQSPKFITENMKWTDVCQ--GQL--GNCWFLAAAASLTQYPLLMAR VVPPQQGFKD-RYVGIFHFQFWQYGEWVDVVVDDRLPVKN-GQLVFVSSAQKSEFWAALL EK---AYAKLNGSYEALNGGFMNEAFVDFTGGLDETVDLK-V---PPPNLYHLIEKAVKK RSLMGASIQ--------------------------------------------------- IQ-------SQY------------------------------------------------ -E--RELTTPEGLVKGHAYSIIATW-----K-------MEQ----NG---RTIHLLRLRN PWG-KVEWNGRWSDN-----------SPLWSQVTFELRE-KMQVR-GEDGEFWMQMEDF- LRFFDILEVCN--LTPESMKD-KC------AH-LWNTNTFSGRWMMGHN-------AGGC RNY-R-----------ATFWTNPQYIVTLTEEDE---DSS-------------------- ---------DGCTLLVSLMQKNRRQYRSRGQDFLVVGFEIYQ---V-----P--K----E --VTQHISQTLKKLSLTQINSVLQSIPFVAKRDVTERYQLPPGRYLLIPSTFQPHQESD- -FILRVFTEKQH------TLI--C---ISHIGICGPVEN--------------------- ------------------------------------QI---FS-KMQME-DFLR---FFD ILE-FK---------------------------------------------DQEISPEEL QRI-------------LIQIT-SK------------------------------------ -------------N---------------------------THL------KTNGFS-LDI CRKLVKMV-D---LNCNGKLQLEEFRKLWSKIKEWE--------------------KIFT NYDKDRSGTMDVQELCLALE---------------------------------------- ------AA----GFTLNNQLVESLCQKYGNN-VRQVYFDSFLSCLAYLVCVFGKIT---- -----WTINQSLQNMQ-PLWCFH--MLV >C_familiaris_ENSCAFP00000002900 NLQLSSTTLATNMLYSPACLSGPSSPEQSGKCL--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------DSSHTAAPTGLCLTQTTSLDQGMAA------------HISHSRL- -----KAKGLGQHHNAQNYNN-QNFEDLQAACLRKGELFEDSFFPAEPSSLGFKDLGPNS RNVQNICWQRPGQITSSPHFIVNGFSPTDICQ--GVL--GDCWLLAAIGSLTTCPKLLHR VVPKGQSFRK-NYAGIFHFQFWQFGQWVDVVVDDRLPTKN-GKLVFVHSAERTEFWSALL EK---AYAKLNGSYEALSGGSTVEGFEDFTGGVTYTIQLQ-K---PPRNLLRMLRKAVER SSLMGCSIE--------------------------------------------------- IV-------SES------------------------------------------------ -E--LETMTQKMLVRGHAYSVTDLQ-----E-------VWY----QG---RTETLIRVRN PWG-RVEWNGAWSDN-----------ASEWDKVDVDTIE-QQLNE-KEDGALWSVHARF- LLHHTPHR--A--LTPAARGN-PW------QH-FQNCVLQNATNSRGAP-------T-AC RPQ-A-----------RLHWFGTSYERSMENGHI---PEN----ETS------------- ---------GLLILMLELLAIRALAPPHPHQCPSALNIPQHT---V-----P--K----E --FQNVQDIHFKKDFFLKYQDHGFSEIFTNSREVSSHLQLPPGEYVIIPSTFEPHKDAD- -FLLRVFTEKHS------ESW--E---LDEANYAELLQ---------------------- -------------------------------E--E-HF---SE-NDVDQ-DFIH---LFE IVAGGE---------------------------------------------GKEIGMYEL QKL-------------LNKVV-TK------------------------------------ -------------L---------------------------RNF------RTQGFG-LDV CRCMVNLM-D---KDGSGKLGLPEFQILWKKIKKWT--------------------DIFR ECDEDHSGSLNSYEMRLAIE---------------------------------------- ------KA----GIKLSNKVTQVLVARYSNE-DMIVDFDSFISCFLRLKAMFTYFLSMDP KNT--GYIHLNLN--Q-WLQ-TI--MWG >M_domestica_ENSMODP00000032871 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------MTEEIITPV-YCTGVSA------------QVKKQRA- -----KDLGLGSHENSIKYLG-QDYDQLRSQYLQAGVLFQDETFPPSPHSLGFKELGPNS SKIYGVKWKRPTELLSNPQFIVDGATRTDICQ--GAL--GDCWLLAAIASITLNEPILHR VVPHGQSFQD-GYAGIFHFQLWQFGEWVDVVVDDLLPTKD-GKLVFVHSAQGNEFWSALL EK---AYAKVNGSYEALSGGSTSEGFEDFTGGVTEWFNLR-K---PPQDLYQIILKALER GSLLGCSID--------------------------------------------------- VSLLPLAPPSFQ------------------------------------------------ -P--HFCCPFYFIFQRSMYFPSQPP-----P-------IEK----KN---K----TRATN GHR-TVPLSHAPSPP-----------PPLCPGESPAFLR-----------EFWGPPS--- LSYPPVLLWVL--LTPFWISS-YKSRVSSLFA-AQSPSFLSGRAPSSPP-------KREA QKH-F-----------TTFWVNPQFKIKLEEVDD---QPDGHFGGHD------------- ---------SGCSILLALMQKHRRRERRYGRDMETIGFAVYD---V-----P--R----E --LVGKPSVHLKREFFLSHSSRARSEEFINLREVSSRLCLPPGEYIVVPSTFEPNKEGD- -FVLRFFSEKKA------GTE--E---LDDKIEAHLPD---------------------- -------------------------------E--R-VL---SE-EEIDD-TFKN---LFK QLA-GA---------------------------------------------DMEISVKEL QTI-------------LNKIV-GK------------------------------------ -------------H---------------------------KDL------RTDGFS-KES CRSMVNLM-D---RDGNGKLGLVEFNILWNRIKNYL--------------------TIFR KYDVDKSGSMSSYEMRMALE---------------------------------------- ------AA----G----------------------------------------------- ---------------------------- >G_aculeatus_ENSGACP00000026120 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MPL------------QSTLSGR- -----GSGAGPERAEDTQSDG-KSFEELRHECLQKGVLFEDQDFPAADSSLYFSE----- SVPVNIEWKRPKEICKDPKFIVGGADRTDICQ--GQL--GDCWLLAAIASLTLKKEALAR VVPPDQDFDR-RYAGIFHFQFWSHNRWLDVVVDDRLPVVR-NKLIMLHSASNDEFWSALL EK---AYAKLHGSYESLKGGSTMEAMEDFTGGVGENYETK-N---CPDNLFSIMKKALDR GSMMGCSID--------------------------------------------------- IT-------SSA------------------------------------------------ -E--SEAKTTTGLVKGHAYSITSLE-----EFHLSTFQVNF----RG---KTVQLIRVRN PWG-QVEWNGPWSDG-----------SREWNYVDSGDKN-RLLQL-SDDGEFWMEFSDF- KKNYDKVEICN--MTPDDLTD-DS------KR-QWAVSMFEGNWIRGST-------AGGC RNF-I-----------DTFWTNPQFKLKLEDADD---D---------------------- ---------DVCSVVIALMQKNRRKLRKEGMDMETIGFAVYE---A-----P--E----D -------EDQLGKDFFRYNASKARSRTYINVREISERFTLPPGSYLLVPTTFQPHHEAD- -FIVRVFSEKKA------EAL--E---MGSNVDADLPD---------------------- -----------------------------PPPPSA-PE---DE-SDEEK-GLRR---LFE QLA-GDSSFLFYWSKNRPMKEERRRPVRVVFTLFLRTVFSVWCSRPQRNPNDSRVSVCKI IEIRCHEMKKPQTFVPLNKKK-HR------------------------------------ -------------R-------------SLFKNCSKSVSLSGKEI------KFDGLS-LST CHSIINLM-DEHQVDNTGQLEFQEFKVFWEKMKKWI--------------------MLFL AFDTDRSGKMSSYELRSALK---------------------------------------- ------AA----GMQLNNRLLQLIGLRFADD-KYDIDFDDYLTCIVRLENMFIIYFQSKI TKK--SSVIFSKV--L-WMV-LL--IQS >O_cuniculus_ENSOCUP00000000421 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MPY------------LHRDSGP- -----QAQPTPKDARITHSSG-QSFEQLRQGCLRKGALFEDPDFSANNSSLFYSE----- RPPVPFEWKRPGXXXXXXXXXXXXXXXXXXCQ--GEL--GDCWLLAAIASLTLNEKALAR VVPQEQSFGP-GYAGIFHFQFWQHSEWLDVVIDDRLPTFR-GRLVFLHSAEHREFWGALL EK---AYAKLNGSYEALKGGSTIEAMEDFTGGVAENFLTK-E---APENFYEILEKALKR GSLMGCSID--------------------------------------------------- TR-------NAT------------------------------------------------ -E--SEARTPFGLIKGHAYTITGID-----Q-------VNF----RG---QKVELIRVRN PWG-HVEWNGSWSDS-----------SPEWRSVDLDEQK-RLCHMTLDDGEFWMAFKDF- KVHFDKVEICN--LTPDALEE-DA------LH-KWEVIVHQGSWVRGST-------AGGC RNF-L-----------DTFWTNPQIRLSLTETDE---GQE-------------------- ----------ECTFLVALMQKDRRKLKRLGADVLTIGYAIYQ---S-----P--G----R -------EGHLDKDFFKYHASQARSKTFINLREVSGRFRLPPGDYILIPSTFEPHQEAD- -FCLRIFSEKKA------ITR--X---XXXXXXXXXXX---------------------- -----------------------------PPKPTP-PG---QE-TEEEQ-QFRA---LFE KVA-GE---------------------------------------------DMEVTAEEL EYV-------------LNAVL-EK------------------------------------ -------------K---------------------------KDI------KVKKLS-LIS CKNIISLM-D---SSGNGKLEFNEFKVFWNKLKQWI--------------------DXXX XXXXXXXXXXXXXXXXXXXX---------------------------------------- ------XX----XFQLGSHVLQLVVLRYADE-ELQLDFDDFLNCLVRLENASRVFQALST KNK--EFIHLNIN--E-FIN-LT--MNI >X_tropicalis_ENSXETP00000026925 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------EICENPQFILGGANRTDICQ--GDL--GDCWFLAAIACLTLNEKVLFR VIPPDQNFTD-NYAGIFHFQFWRYGDWVDVIIDDYLPTYN-NELVFTKSSQRNEFWSALL EK---AYAKLHGSYEALKGGNTTEAMEDFTGGVTEFYELK-E---APKDMYNIMKKAFER GSLIGCSID--------------------------------------------------- TL-------VPV------------------------------------------------ -Q--LETRMANGLVKGHAYSVTGVE-----E-------TKL----KG---KPIKLVRLRN PWG-QVEWNGAWGDN-----------AKEWTMVDKSEKT-RLQHQVQEDGEFWFFFKHT- EK---------------TLEH-NK---------KETSFYNEDELGQRCYSRGGLPFANAC DTA-P-----------YTYWTNPQYRLKLLEEDD---DPA----DNE------------- ---------VVCSFVVALMQKNRRKDRKAGANLFTIGFAIYE-QVI-----R--H----K --MHGN-NQHLQKDFFLYNASKAKCKSYINMREVCQRFRLPPSEYVIIPSTYEPHQEGE- -FILRVFSEKRN------ISD--QSLFVDAGVSEYPETV--------------------- ------------------------------------QY---TE-TEEEK-QFRN---IFQ QIA-GD---------------------------------------------DMEISADEL QSV-------------LNNVV-NK------------------------------------ -------------H---------------------------KTL------KSSGFT-LES CRSMIALM-D---TDGCGRLNLQEFYHLWQKIKQWQ--------------------KIFL RFDSDQSGTISSFEMRNAIN---------------------------------------- ------EA----GFHLNNQLYDIITMRYANK-RMDLDFDSFICCFVRLEGMFNFKYVCSM RVQ--LLTECFILSFQ-WLQ-LT--MYA >M_mulatta_ENSMMUP00000007740 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MPY------------LYRAPGP- -----QAHPVPKDARTTHSSG-QNFEQLRQECLQRGTLFEDADFPASNSSLFYSE----- RPQVPFVWKRPGEIVKNPEFILGGATRTDICQ--GEL--GDCWLLAAIASLTLNQKALAR VIPQDQSFGP-GYAGIFHFQFWQHSEWLDVVIDDRLPTFR-DRLVFLHSADHNEFWSALL EK---AYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQMK-E---APENFYEILEKALKR GSLLGCFID--------------------------------------------------- TG-------SAA------------------------------------------------ -E--SEARTPFGLIKGHAYSVTGID-----Q-------VNF----RG---QRIELIRVRN PWG-QVEWNGSWSDS-----------SPEWRSVGPAEQK-RLCHTALDDGEFWMAFKDF- KAHFDKVEICN--LTPDALEE-DA------VH-KWEVTVHQGSWVRGST-------AGGC RNF-L-----------ELFGETPLFYHLGYFPSN---GKH-------------------- ----------DSCHRVGFRHSSIRALIPFACNSLIHAGAVIE---I----NP--T----Q -------TAHYQRGYFAFSLGIIRSSVGGLIEQGEERIGLPPGEYILIPSTFEPHQETD- -FCLRIFSQKKA------ITR--D---MDGNVDIDLPE---------------------- -----------------------------PPKPTP-PD---QE-TEEEL-RFRA---LFE QVA-GE---------------------------------------------DMEVTAEEL EYV-------------LNAVL-RK------------------------------------ -------------K---------------------------KDI------KFKKLS-LIS CKNIISLM-D---TSGNGKLEFDEFKVFWDKLKQWI--------------------NLFL RFDADKSGTMSTYELRTALK---------------------------------------- ------AA----GFQLSSHLLQLIVLRYADE-ELQMDFDDFLNCLVRLENASRVFQALST KNK--EFIHLTIN--E-FIH-LT--MNI >D_melanogaster_FBpp0076072 MYGIDNYPKNYHASGIGLVNLAALGYSKNEVSGGNEGGGAPKPKAGLYPSLPYPSSESVG GMPYVVKQTSHAQNASYAGPTMGMGMPVPEAPSAPAPYPSATPYPGSGLYPSLPSANVSS LPYPTAPMAPYPTGMPYPTGMPQPNLPYPAAPLAPYPSAMPGLPGMPMPYAPMPTSPAPQ HNIGFPALPYPTAPPPESAPTQEEEPSVGVAELSFTSVKV------------PENQNMF- -----WMGRKATSARQNSVSK-GDFQSLRDSCLANGTMFEDPDFPATNASLMYSR----- RPDRYYEWLRPGDIADDPQFFVEGYSRFDVQQ--GEL--GDCWLLAAAANLTQDSTLFFR VIPPDQDFQE-NYAGIFHFKFWQYGKWVEVVIDDRLPTYN-GELIYMHSTEKNEFWSALL EK---AYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIK-E---APPNLFSIMMKAAER GSMMGCSLE--------------------------------------------------- -P-------DPH------------------------------------------------ -V--LEAETPQGLIRGHAYSITKVC-----L-------MDISTPNRQ---GKLPMIRMRN PWGNDAEWSGPWSDS-----------SPEWRFIPEHTKE-EIGLNFDRDGEFWMSFQDF- LNHFDRVEICN--LSPDSLTE-DQ--QHSSRR-KWEMSMFEGEWTSGVT-------AGGC RNF-L-----------ETFWHNPQYIISLEDPDD---E------DDD------------- ---------GKCTAIVALMQKNRRSKRNVGIDCLTIGFAIYH---L-----T--D----- ---RDMQVKPQGLNFFKYRASVARSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGE- -FIIRVFSETRN------NME--E---NDDEVGFGETDDRI------------------- -----------------------------APSLPP-PTPKEED-DPQRI-ALRR---LFD SVA-GS---------------------------------------------DEEVDWQEL KRI-------------LDHSM-RD------------------------------------ -----------------------------------------VMV------GSDGFS-KDA VRSMVAML-D---KDRSGRLGFEEFEALLTDIAKWR--------------------AVFK LYDTRRTGSIDGFHLRGALN---------------------------------------- ------SA----GYHLNNRLLNALAHRYGSR-EGQIPFDDFLMCAIKVRTFIEMFRERDT DNS--DTAFFNLD--D-WLE-RT--IYS >A_aegypti_AAEL003952-PA ----------------MTTNSSVVESLVQRVVERN------------------------- ------------------------------------------------------------ -----LVY-----VSPQVFDRGG----------RESVEFSGGGVVYQYGMYDRSYGRYCQ ENPMES-------YYYDSYEYQCPVHARYLPQIPLKKYYT------------PDGEYIY- -----R-LGEKGSGFRTRTDV-QDYYVLRSQCLESGSLFEDPEFQAVSSSLMFSR----- RPDRHYEWLRPHEICENPEFFVEGFSRFDVQQ--GEL--GDCWLLAACANLTQDQKMFLR VVPEDNSFED-DYAGIFHFRFWQYGRWVDVVIDDRLPTYR-GELIYMRSSEKNEFWSALL EK---AYAKLHGSYEALKGGTTCEAMEDFTGGVTEMYDLKDQ---TPPNLFAIIEKGFQR NSMFACSIE--------------------------------------------------- -P-------DPH------------------------------------------------ -V--TEAETREGLIRGHAYSITKIQ-----L-------VDIVTPGTS---GKIPLIRLRN PWGNEAEWNGAWSDQ-----------SAEWRYIPDEQKE-ELGLNFDCDGEFWMSYRDF- TRYFDRIEICN--LSPDSLSE-EQ--VNRGKL-RWEMSTFEGEWAIGST-------AGGC RNY-L-----------QTFWHNPQYVVHLDDPDE---D------DDE------------- ---------GKCTVIIALMQKNRRSRRNMGVDCLTIGFAVYR---V-----T--E----- ---RDLAQKPLKMNFFKYNASVARSPAFINLREVSCRFKLPPGEYLIVPSTFEPNEEGE- -FLIRVFSECKN------SME--E---NDEEVGVGEIDDRI------------------- -----------------------------APDVPV-PS---QP-SPARQ-AMER---LFL DVA-GA---------------------------------------------DGEVDWVEL KRI-------------LDHSF-RD------------------------------------ -----------------------------------------VDQ------GSSGFS-KDV CRSMVAML-D---TDQSGKLGFEEFQSLLTDISKWK--------------------AVFK LYDQDQTGRLSAFELREALH---------------------------------------- ------SA----GYHLNNRILNGLVHRYGSR-DGSIAFDDFIMCAVKIKTMIDIFRERDT EGT--NMATFSMD--E-WVE-KT--LYS >A_gambiae_AGAP012068-PA PAAFAQSPPASQWPTVPTPGSSGYSSLNPSISGQS------------------------- ------------------------------------------------------------ -----LSYGFNPNVMPALPDSGAGYPPAGNQLPYPTMGFAGFGSPMDYTMPN-------- ---LPP-------PVPDALLRGAEPAAATCEEIPFQSISI------------PIAEGMF- -----SPLGDRNAGQRSSFDV-QDFYQIRQQCLDNGTLFEDPEFPASASSLMYSK----- RPDRHYEWLRPHEICDGPEFFVEGFSRFDVQQ--GEL--GDCWLLAACANLTQDHKMFLR VVPEDNSFED-GYAGVFHFRFWQYGKWVDVVIDDRLPTYR-GQLIYMRSSEQNEFWSALL EK---AYAKLHGSYESLRGGTTCEAMEDFTGGVAEMYDLKDQ---TPPNLFEIIEKGFKR NSMFGCSIE--------------------------------------------------- -A-------DPH------------------------------------------------ -V--LEAETPEGLIRGHAYSITKIQ-----L-------VDIETPGRS---GKIPLIRLRN PWGNEAEWNGPWSDK-----------SPEWRYIPDEQKQ-ELGLNFDHDGEFWMSYRDF- TRYFDRMEICN--LSPDSLSD-DE--MTRGKI-SWEMSMFEGEWAVGTT-------AGGC RNY-L-----------DTFWHNPQYVIRLDDPDE---D------DEE------------- ---------GNCTVIIALLQKNRRSRRNMGVECLTIGFAVYR---V-----T--E----- ---RDLAQKPLKMNFFKYNASAARSPAFINLREVSCRFKLPPGTYVIVPSTFEPNEEGE- -FIIRVFSETAN------SMM--E---NDDNVGVGDLDDRI------------------- -----------------------------APDVPG-YV---QP-SPQRQ-AMER---LFL DVA-GA---------------------------------------------DGEVDWVEL KRI-------------LDHSF-RD------------------------------------ -----------------------------------------DNI------SSEGFS-KDV CRAMVAML-D---VDHTGKLGFEEFQQLLTDIAKWK--------------------AVFK LYDTEGSGRLSPFQLREALN---------------------------------------- ------SA----GYHLNNRILNALVHRYGSR-SGTIPFDDFIMCAVKIKTMIEIFRERDT DGT--NQATFSMD--E-WVE-KT--LYS >D_melanogaster_FBpp0085714 MDDLRGFLRQAGQEFLNAAGEAAMGAAKDVV----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GSVINEIFIKKEADTKRVL------------PSIKNM-- -----RVLGEKSSSLGPYSEV-QDYETILNSCLASGSLFEDPLFPASNESLQFSR----- RPDRHIEWLRPHEIAENPQFFVEGYSRFDVQQ--GEL--GDCWLLAATANLTQESNLFFR VIPAEQSFEE-NYAGIFHFRFWQYGKWVDVIIDDRLPTYN-GELMYMHSTEKNEFWSALL EK---AYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLK-E---APGNLFTILQKAAER NSMMGCSIE--------------------------------------------------- -P-------DPN------------------------------------------------ -V--TEAETPQGLIRGHAYSITKVC-----L-------IDIVTPNRQ---GKIPMIRMRN PWGNEAEWNGPWSDS-----------SPEWRYIPEEQKA-EIGLTFDRDGEFWMSFQDF- LNHFDRVEICN--LSPDSLTE-DQ--QNSGKR-KWEMSMYEGEWTPGVT-------AGGC RNF-L-----------DTFWHNPQYIITLVDPDE---E------DEE------------- ---------GQCTVIVALMQKNRRSKRNMGMECLTIGFAIYS---L-----N--D----- ---RELENRPQGLNFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGE- -FIIRVFSETQN------NME--E---NDDHVGYGGKADTI------------------- -----------------------------TPGFPT-PK---PI-DPQKE-GLRR---LFD SIA-GK---------------------------------------------DMEVDWMEL KRI-------------LDHSM-RDDLPKPVVFNRFSNNMAFETQAAGPGDDGAGACGLLS LICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPVTANAIVD------ETHGFS-KDV CRSMVAML-D---ADKSGKLGFEEFETLLSEIAKWK--------------------AIFK VYDVENTGRVSGFQLREALN---------------------------------------- ------SA----GYHLNNRVLNVLGHRYGSR-DGKIAFDDFIMCAVKIKTYIDIFKERDT EKN--ETATFTLE--E-WIE-RT--IYS >C_intestinalis_ENSCINP00000015499 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------NPQIDIQN-KTVSEVKEELVRKKILYEDPEFPADGNALFYSP--PHQ RPRMDVEWKRPHDISNDPQLFVGGASRFDIMQ--GEL--GDCWLLAAIASLSLNDDLLYR IIPPDQSFSQ-DYCGMFHFQFWQYGEWIDVMVDDLLPTVR-GKLVYLHSAQNNEFWSALL EK---AYAKLNGSYEALKGGSTTEAMEDFTGGVTEVIDLK-E---APNNLYSVMHKSLKK GALMGCAVE--------------------------------------------------- VI-------CKS------------------------------------------------ -Q--REAKLSNGLLMGHAYSITGLD-----I-------CTV----QAYLRNGVKLVRVRN PWG-QVEWNGAWSDGFIPFFVIFFKFSSSWNRVP-DEKQ-RLDVEFGEDGEFWMSYEDF- CRCFTKLEICN--LGPDAVED-DD------VSTQWITSLHEGRWTRGCT-------AGGC RNF-PVGNTLLFIPKSYTFWVNPQFRLILEEEDD---DPD----DDV------------- ---------VGCSFILSLMQKNRRKQKVKGQGLLTIGFALYK---L-----K--E----S --VAP--NQTLKKDFFLYNQSVARSKNFINLRENSQRFKLPPGEYCIVPSTFQPNEEAD- -FVLRIYTEKRA------ETG--E---LDEETKQTVPVAPEPHFPFYNNFVNPFHQNCFH SVALA------------------------SQYPQK-NN---DE-NENDK-KFKK---LFD QLT-GEVFNSSKLIPHFFLHSEAFFFHYMLL-------------------QDGEIDAFEL RDI-------------INSVM-KK------------------------------------ -------------S---------------------------DAG------KFEGFG-LEA CRSMVALM-D---VTNSGKLDYDEFKALWVRVRKWI--------------------NIFK KFDIDGSGNFDSYELREALSHAGKKSSVENMLDTECCTCFYLHGSAALGQNYSFLLKSHE FLPVIFRA----GYSLSSRLYQMLCVRYASK-DLTINMDDFVLLSVRLETMFNSFNEFKG SGKE-AKISLEAV--S-KLG-TF--IYS >G_gorilla_ENSGGOP00000013652 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KDLGPGS PQTQGIIWKRPTELCPSPQFIIGGATRTDICQ--GGL--GDCWLLAAIASLTLNEELLYR VVPRDQDFQE-NYAGIFHFQFWQYGEWVEVVIDDRLPTKN-GQLLFLHSEQGNEFWSALL EK---AYAKLNGCYEALAGGSTVEGFEDFTGGISEFYDLK-K---PPANLYQIIRKALRA GSLLGCSID--------------------------------------------------- VS-------SAA------------------------------------------------ -E--AEAITSQKLVKSHAXSVTGVE-----E-------VNF----QG---HPEKLIRLRN PWG-EVEWSGAWSDD-----------ASP--IISPSAEGCRVKHT-IMRSMSQMSLSDF- VRQFSRLEICN--LSPDSLSX-EE------VH-KWNLVLFNGRWTRGST-------AGGC QNY-P------------------------------------------------------- -----------------------------------------D---V-----L-------- --LCWYTLDVLGLNILASH----CSTSFLLLEEASLLLYIP------LPVALLRIRDSF- -LWLKSRRLRRI------CPQ--A---CHDALPFWQRP---------------------- -------------------------------SSVP-HP---WM-VSLEV--------FYR ----GG-------------------------------------------------SFPHL QMI-------------RFPLP-FS------------------------------------ -------------R---------------------------TDI------KFDGFN-INT CREMISLL-D---SNGTGXLGAVEFKTLWLKIQKYL--------------------EIYR ETDYNHLGTIDAHEMRTALR---------------------------------------- ------KA----GFTLNSQVQQTIALRYACS-KLGINFDSFVACMIRLETLFKLFSLLDK DKD--GMVQLSLA--E-WLC-CV--LV- >O_cuniculus_ENSOCUP00000015069 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DITSNPQFIANGISPTDICQ--GIL--GDCWLLAAIGSLTTCPKLLYR VVPRGQSFRK-NYAGIFHFQLWQFGQWMDVVVDDRLPTKN-NKLVFVHSVQNSEFWSALL EK---AYAKLSGSYEALAGGSTMEGLEDFTGGVAQSFQLQ-R---PPPDLLRLLRKAVER SSLMGCSIE--------------------------------------------------- VN-------SDS------------------------------------------------ -D--LESVTHRMLVRGHAYAVTGLQ-----D-------VLF----RG---KAETLIRVQN PWG-RIEWNGAWSDN-----------AREWEEVSPDMQI-ELLHK-KEDGEFWMSYQDF- LKNFTLLEICT--FTPDTLSR-EY------KS-YWDTTFYXXXXXXXXX-------XXXX XXX-X-----------XXXXXXXXXXXXXXXXDDPDEDSE----DNT------------- ---------IVCTCLVALMQKNWRHGRPQGSQLHTIGFVIFS---V-------------- --FQNIQDVHLKKDFFTKYQDHGFSEIFTNSREVSSQLRLPPGDYIIIPSTFEPHRDAD- -FLLRVFTEKHS------ESW--E---LDEVNYLEQLQ---------------------- -------------------------------E--E-NV---SE-EALDQ-NFIR---LFE IVA-GE---------------------------------------------XXXXXXXXX XXX-------------XXXXX-XX------------------------------------ -------------X---------------------------XXX------XXXXXX-XXX XXXXXXXX-X---KDGSGKLGLLEFQILWKKIKKWT--------------------DIFQ ECDQDNSGTLNSYEMRLAIE---------------------------------------- ------KA----GIKLNNKVMQVVVARYADD-NMIVDFNSFISCFLKLKAMFTFFLTMDP QNT--GCIHVNLQ--Q-WLQ-AI--MWG >P_pygmaeus_ENSPPYP00000018628 MLSSPGPSLP-----------------ESAESL--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------DGSQEDKPR-GSCAEPTFTDTGMVA------------HINNSRL- -----KAKGVGQHDNAQNFGN-QSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNS KNVQNISWQRPKDIISNPLFIMDGISPTDICQ--GIL--GDCWLLAAIGSLTTCPKLLYR VVPRGQSFKK-NYAGIFHFQIWQFGQWVNVVVDDRLPTKN-DKLVFVHSTERSEFWSALL EK---AYAKLSGSYEALSGGSTMEGLEDFTGGVAQSFQLQ-R---PPQNLLRILRKAVER SSLMGCSIE--------------------------------------------------- VT-------SDS------------------------------------------------ -E--LESMTDKMLVRGHAYSVTGLQ-----D-------VHY----RG---KMETLIRVRN PWG-RIEWNGAWSDR--------------------------------------MSYQDF- -NNFTILEICN--LT-DALLG-DY------KS-YWHTTFYEGSWRRGSS-------AGGC RNH-P-----------GTFWTNPQFKISLPEGDDPEDDAE----GNV------------- ---------VVCTCLVALMQKNWRHARQQGAQLQTIGFVLYS---V-----P--K----E --FQNIQDVHLKKEFFMKYQDHGFSEIFANSREVSSQLRLPPGEYIIIPSTFEPHRDAD- -FLLRVFTEKHS------ES---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------- >P_pygmaeus_ENSPPYP00000011129 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MASSSG------------RVTIQLV- -----DEEAGVGAGGLQLFRG-QSYEAIRAACLDSGILFRDPSFPAGPDALGYDQLGPDS EKAKGVKWMRPHEFCAEPKFICEDMSRTDVCQ--GSL--GNCWFLAAAASLTLYPRLLRR VVPPGQDFQH-GYAGVFHFQLWQFGRWMDVVVDDRLPVRE-GKLMFVRSEQRNEFWAPLL EK---AYAKLHGSYEVMRGGHMNEAFVDFTGGVGEVLYLR-Q---NSMGLFSALRHALAK ESLVGATA---------------------------------------------------- ---------LSD------------------------------------------------ -R--GEYRTEEGLVKGHAYSVTGTH-----K-------VFL----GF---TKVRLLRLRN PWG-RVEWTGAWSDS-----------CPRWDTLPTECRD-ALLVK-KEDGEFWMELRDF- LLHFDTVQICS--LSPEVLGPSPE------GG-GWHVHTFQGRWVRGFN-------SGGS QPN-A-----------ETFWTNPQFRLTLLEPDE---E-D----EDE-EGPWGGWGAAGA RGPVQGGRTPKCTVLLSLIQRNRRRLRAKGLTYLTVGFHVFQ---I-----P--E----E --LLGLWDSPRSRTLLPRLLRADRS-PLSARRDVTRRCRLRPGHYLVVPSAAHAGDEAD- -FTLRVFSERRH------TAV--E---IDDVISANLQFL--------------------- ------------------------------------QG---AY-LPLEL-GLEQ---LFQ ELA-GE---------------------------------------------EEELNAFQL QAL-------------LSIAL-EP------------------------------------ -----------------------------------------ARA-HTRTRTPREIG-LRT CEQLLQCF-G-----HGQSLALHHFQQLWGHLLEWQ--------------------AIFD KFDEDASGTMNSYELRLALN---------------------------------------- ------AA----GFHLNNQLTQALTSRYRDS-RLRVDFERFVSCVAQLTCIFCHCSQHQD GGE--GVICLTHR--Q-WME-VA--TFS >G_gorilla_ENSGGOP00000003031 MLYSPGPSLP-----------------ESAESL--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------DGSQEDKPR-GSCAXXXXXXXXXXX------------XXXXXXX- -----XXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXDIISDPLFIMDGISPTDICQ--GIL--GDCWLLAAIGSLTTCPKLLYR VVPRGQSFKK-NYAGIFHFQIWQFGQWVNVVVDDRLPTKN-DKLVFVHSTXRSEFWSALL EK---AYAKLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-X---XXXXXXXXXXXXXXX XXXXXXXXX--------------------------------------------------- VT-------SDS------------------------------------------------ -E--LESMTDKMLVRGHAYSVTGLQ-----D-------VHY----RG---KMETLLRVRN PWG-WIGWNGAWSDS-----------AREWEEVASDIQM-QLLHK-TEDREFWMSYQDF- LNNFTLLEICN--LTPDTLSG-DY------KS-YWHTTFYEGSWRRGSS-------AGGC RNH-P-----------GTFRTNPQFKISLPEGDDPEDDAE----GNV------------- ---------VVCTCLVALMQKNWWHARQQGAQLQXXXXXXXX---V-----P--K----E --FQNIQDVHLKKEFFTKYQDHGFSEIFANSREVSSQLRLPPGEYIIIPSTFEPHRDAD- -FLLRVFTEKHS------ESW--E---LDEVNYAEQLQ---------------------- -------------------------------E--E-KV---SE-DDMDQ-DFLH---LFK IVA-GE---------------------------------------------GKEIGVYEL QRL-------------LNRMA-IK------------------------------------ -------------F---------------------------KSF------KTKGFG-LDA CRCMINLM-D---KDGSGKLGLLEFKILWKKLKKWM--------------------DIFR ECDQDHSGTLNSYEMRLAIE---------------------------------------- ------KA----GIKLNNKVMQVLVARYADD-DLIIDFDSFISCFLRLKTMF-------- ---------------------------- >H_sapiens_ENSP00000331636 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MASSSG------------RVTIQLV- -----DEEAGVGAGRLQLFRG-QSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDS EKAKGVKWMRPHEFCAEPKFICEDMSRTDVCQ--GSL--GNCWFLAAAASLTLYPRLLRR VVPPGQDFQH-GYAGVFHFQLWQFGRWMDVVVDDRLPVRE-GKLMFVRSEQRNEFWAPLL EK---AYAKLHGSYEVMRGGHMNEAFVDFTGGVGEVLYLR-Q---NSMGLFSALRHALAK ESLVGATA---------------------------------------------------- ---------LSD------------------------------------------------ -R--GEYRTEEGLVKGHAYSITGTH-----K-------VFL----GF---TKVRLLRLRN PWG-CVEWTGAWSDS-----------CPRWDTLPTECRD-ALLVK-KEDGEFWMELRDF- LLHFDTVQICS--LSPEVLGPSPE------GG-GWHVHTFQGRWVRGFN-------SGGS QPN-A-----------ETFWTNPQFRLTLLEPDE---EDD----EDE-EGPWGGWGAAGA RGPARGGRTPKCTVLLSLIQRNRRRLRAKGLTYLTVGFHVFQ---I-----P--E----E --LLGLWDSPRSHALLPRLLRADRS-PLSARRDVTRRCCLRPGHYLVVPSTAHAGDEAD- -FTLRVFSERRH------TAV--E---IDDVISADLQSL--------------------- ------------------------------------QG---PY-LPLEL-GLEQ---LFQ ELA-GE---------------------------------------------EEELNASQL QAL-------------LSIAL-EP------------------------------------ -----------------------------------------ARA-H--TSTPREIG-LRT CEQLLQCF-G-----HGQSLALHHFQQLWGYLLEWQ--------------------AIFN KFDEDTSGTMNSYELRLALN---------------------------------------- ------AA----GFHLNNQLTQTLTSRYRDS-RLRVDFERFVSCVAHLTCIFCHCSQHLD GGE--GVICLTHR--Q-WME-VA--TFS >M_mulatta_ENSMMUP00000008472 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MACSSG------------RVTIQLV- -----EEEAGVGAGGLQLFRG-QSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDS EKAKDVKWMRPHEFCAEPKFICEDMSRTDVCQ--GSL--GNCWFLAAAASLTLYPRLLRR VVPPGQDFQH-GYAGVFHFQLWQFGRWVDVVVDDRLPVRE-GKLMFVHSEQRNEFWAPLL EK---AYAKLHGSYEVMRGGHMNEAFVDFTGGVGEVLYLR-Q---NSMGLFSALRHALAK ESLVGATA---------------------------------------------------- ---------LSD------------------------------------------------ -R--GEYRTEEGLVKGHAYSVTGTH-----K-------VFL----GF---TKVRLLRLRN PWG-RVEWTGAWSDS-----------CPRWDALPTECRD-ALLVK-KEDGEFWMELRDF- LLHFDTVQICS--LSPEVLGPSPE------GG-GWHVHTFQGRWVRGFN-------SGGS QPS-A-----------ETFWTNPQFRLTLLEPDE---EED----EDE-EGPWGGWG-SGA WGPARGGRTPKCTVLLSLTQRNRRRLRAKGLTYLTVGFHVFQ---I-----P--E----E --LLGLWDSPRSRALLPRLLRADRS-PLSARRDVSRRCRLRPGHYLVVPSTAHAGDEAD- -FTLRVFSERRH------TAV--E---IDDVISADLQAL--------------------- ------------------------------------QG---PY-LPLEL-DLEQ---LFK ELA-GE---------------------------------------------EEELNAWQL QAL-------------LSIAL-EP------------------------------------ -----------------------------------------ARV-H--TRTPREIG-LRT CEQLLQCF-G-----HGQSLALHHFQRLWGHLLEWQ--------------------AIFH KFDEDASGTMNSFELRLALN---------------------------------------- ------AA----GFHLNNQLTQALTSRYRDS-RLRVDFERFVSCVAQLTCIFCHCSQHLD GGE--GVICLTHR--Q-WME-AA--TFS >B_taurus_ENSBTAP00000042182 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SR------------RVTIQLV- -----NEETGPETKGPKLFRG-QNYKAIRAACLDEGILFQDPYFPAGPDALGYDQLGPHS EKAKGVEWKRPHEFCTEPQFICEDMSRTDVCQ--GRL--GNCWFLAAAASLTLYPRLLSR VVPPGQGFQH-GYAGVFHFQLWQFGHWVDVVVDDRLPVCK-GKLMFVCSDQRNEFWAPLL EK---AYAKLHGSYEVMRGGHMNEAFVDFTGGVGEVLYLK-KDTPNPPGIFSILRHALAK ESLVGATA---------------------------------------------------- ---------LSD------------------------------------------------ -R--GEYRTEDGLVKGHAYSVTGTH-----K-------VSL----GF---TRVRLLRLRN PWG-RVEWNGAWSDS-----------CPRWDALPTEWRD-ALLVK-KEDGEFWMELLDF- FRHFDTIQICS--LSPEVLGPSPA------GG-GWHIHTFQGRWVRGFN-------SGGS QPG-A-----------ETFWTNPQFRLTLLEPDE---EDE----EED------------- ------GSLGCCTVLLSLIQRNQRRLRAQGLRYLTVGFHVFQ---I-----P--E----E --LLGLWDSPRSRAHLSGLLRADRS-PFCARRDVSRRCRLRPGHYLVVPSAARAGDEAD- -FTLRVFSERRH------TAA--E---VDDVISADLHAL--------------------- ------------------------------------MV---PY-IPLEL-ELQQ---LFQ ELA-GE---------------------------------------------EEELGAPQL QIL-------------LSIAL-EP------------------------------------ -----------------------------------------GELG---TKSGSPEP-PYT HPN--QML-P---PQHGGSLDLYHFQQLWGHLLEWQ--------------------ATFD KFDEDASGTMNSYELRLALN---------------------------------------- ------AA----GFHLNNQLTQALTSRYRDS-RLRVDFERFVSCMAQLICVFR------- ---------------------------- >A_aegypti_AAEL003965-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------MPDPTRIDSLVKEFNDSPHGPKKL------------HQSRTRFM PIVFGRDGKAQPKPGPRSAEA-QDFYALRKRCLRSGTLFEDPEFPANNSSLTFSG----- ESRSNLKWLRPSQISPDPRFFEASYSRFDVNQ--GEL--GDCWLLAAAANLTQDPQLFTR VVPEDNSFKQ-DYAGIFHFRFWRFGQWCDVVIDDRLPTVN-GKLVYMRSTEDNEFWSALL EK---AYAKLFGSYEALRGGSASEAMVDFTGGIAESYEMK-D---VPKDLFQIIEKGFRS HAMFACSLE--------------------------------------------------- -P-------DPY------------------------------------------------ -K--PEAETPQGLIRGHAYSLTMAK-----M-------VDIQTPNVK---GKIPLLRLRN PWGNANEWNGAWSDK-----------SPEWKYIPEETKR-EIGLIFELDGEFWMSYQDF- VKYFDRIEMCN--MSPDCPII-RQ----SGNY-PWKQSSFEGEWVIGST-------AGGC RNY-P-----------DTFWHNPQYVVHLKEPDK---D------DAE------------- ---------GKATAIIALLQKNRRSKRNKGMDCLTVGLIIYR---V-----T--E----- ---RDLIRKPLPKEFFLRNASIARS-TFVNLREVTCRFRMDPGTYVVVPSTFEPNVEGE- -FMIRVFSECPD------CMT--E---NEDCVGECDLDPRI------------------- -----------------------------KMKVPD-PT---KP-DPQRQ-AMEK---LFL DVA-GV---------------------------------------------DGEVDWMEL KLV-------------LDHCF-RDDIAIAAKGVSRSYHVAPVESKKSLTPQGEVVCCGLL AMLQDWY--V---NMAGGDNRPERSTSGDFVVAKERAPLMTAES------SAVGFS-KDA CRSMVAML-D---EDQSGKLGFLEFQKLLTEIARWK--------------------AVFK LYDTDRSGHLNPFELRAALQ---------------------------------------- ------SA----GYHLNSKILNSLMHRYGSR-EGEIWFDDFITCAVKIKTMIDIFRAKDV N----GIASFNMD--E-WIQ-KT--IYC >T_nigroviridis_ENSTNIP00000019735 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---MGCSID--------------------------------------------------- IT-------SAY------------------------------------------------ -E--TEAVTALKLVKGHAYSVTGAE-----E-------VSY----RG---EQVQLIRVRN PWG-QVEWTGAWSDG-----------SKEWNYVSRDEKA-KLNHV-AEDGEFWMSFSDF- TRQFSQLEICN--LTPDTLES-DD------VG-HWNHYQYEGAWRVGST-------AGGC LNY-A-----------ATFTSNPQFLVHLEDVDD---DPL----DGE------------- ---------DGCTFLLGLMQKDGRQQKRLDRNLETIGFAIYK---V----SP--N----N --LRGRGNVHLGPDVLLRQRAVAMSSAFINTREVCDRFTLPPGEYAIVPSTFQPHKNGS- -FILRVFSEKQA------KTS--P---LEEDIGAQIE----------------------- -------------------------------E--E-TI---SE-SDIDP-NFKR---IFQ RIA-GN---------------------------------------------DMEVSVFEL VQI-------------LNNIV-SK------------------------------------ -------------R---------------------------CDI------KTDGFS-LET GHLIISLL-D---KDGSGKLGLMEFHLLWSKIQKYL--------------------EIFK NHDTDNSGTMSSHEMRGAAN---------------------------------------- ------AA----GFHINSAVLQTIVSRHADA-QYAIDFDSFVGCLIKLEMLFKMFTSLEK DGS--GKIELDLQ--Q-VRS-RTKNPAG >M_domestica_ENSMODP00000016738 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MAAQ------------RVTIQLV- -----EDGEGESVQGPASFRG-QCYHAIQDCCLQAGTLFLDPCFPAGPSALGYDQLGPGS EKAKGVEWLRPHEFCENPQFICENMDRTDVCQ--GSL--GNCWFLAAAASLTLYPRLLHR VVPPGQSFQW-GYAGVFHFQLWQFGHWVDVVVDDRLPVRD-GKLLFVRSAQRAEFWASLL EK---AYAKLHGSYEVMRGGHMNEAFVDFTGGVGEVLYLQ-P---NTPGLFSALRHALAK ESLVGATA---------------------------------------------------- ---------LSD------------------------------------------------ -R--GEYRTEDGLVRGHAYSVTGTH-----K-------ITL----GF---AKVRLLRLRN PWG-HVEWSGAWSDS-----------CPRWAALPEAWRE-ALLVK-KEDGEFWMGLEDF- LQHFNTVQICS--LSPEVLGPQPK------GG-GWHVHTFQGRWVRGFN-------AGGG QPG-N-----------ETFWTNPQFQLTLQDPDE---EER----EDDEGGPWGGWGAGGA R-PGMGGRRSKCTVLLSLIQRNRRRLRARGVTYLTVGFHVFR---I-----P--E----E --LLGLQDSPRRRELLAGLLRADRS-PFSIRRDVSRRCRLAPGHYLIVPSTAHVGEESD- -FTFRIYTECQH------TAR--E---IDNAVSADLQVL--------------------- ------------------------------------TT---PS-APLDF-DLEQ---LFH ELA-GE---------------------------------------------EEAISTAQL QAL-------------LSLAL-EP------------------------------------ -----------------------------------------GDWGSSWTHPPGEIG-FRT CEQLIHCF-G----QRGHCLTLPEFQQLWYRLQGWQ--------------------ATFN KFDADKSGTMNSHELRLALN---------------------------------------- ------TA----GFQLNNQLTQLLTSRYRDS-RLRVDLDRFVSCVTQLTCLFRHCSQCLG EGE--GLVYMTKR--Q-WME-LA--TFS >O_latipes_ENSORLP00000023708 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PPGVCL------------NIMEARH- -----KQDGYGSLKTPYRVFD-QDFQQLAKYCLSQRVKFLDETFPPERSSIGEGVLSP-- SDLAKVEWLRPAKIAANPSFVLRGVSRFDFGQ--GTV--GNCWFLASIGALTFQKEIFNQ VVPLEQTFDQ-NYCGLFHFRFWRFGKWVDVVIDDKLPTLN-GRLIFVRSQSQNEFWPALL EK---AYAKVCGSYTDMTAGTPSEAMMDFTGGVHIYIQLS-E---PPQNLWELMCRAGKS GVLMCCGTDQGI------------------------------------------------ ---------KET------------------------------------------------ -S--SNTLSPNGLVLGHAYTVTGVI-----Q-------LVS----RG---KPVNLVRLWN PWR-TGEWRGDWCDR-----------SPLWQTVSPKDRE-KCHAV-DDDGEFWMTLEDF- CKLYSDLDICG--MDPNFLD--ET------PC-QWKTSVHEGRWVPGTT-------AGGC MNN-K-----------ETFWTNPQFRVQISGEFS----------EKV------------- ---------DGKNTFVSLIQKPDKRKRHLVKNQ-HIGFSIFE---S-----F--E----M --FLKSFSTYANTSFFSTQRPVAQTKTFMNAREVMEFIRLKPGEYLIVPSTFKPNESAS- -FLLTIHSKIET------HGL----------YAHTFNPP-ETRVFYLQTE---------- ------------------------------------RV---KN-PEEDE-KKKR---FFR QHS-NK---------------------------------------------YEEVDAEQL QKI-------------LNDQI-LK------------------------------------ -------------A---------------------------GDL------KSGGFS-IDA CRSMVALM-D---SSITGSLNSKEFVRLWNKVIAFK--------------------DIFF QTDVSRTGTLSLSELRNAII---------------------------------------- ------AS----GIKVNDELLNLMALRYSAS-SGHVTLESFISLILRLECMCKIFKQLSD GKT----MTLQESEFQ-WMY-VS--MY- >R_norvegicus_ENSRNOP00000027645 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MASGNR------------KVTIQLV- -----DDGAAAGAGGPQLFKG-QNYEAIRAACLDSGILFRDPCFPAGPDALGYDKLGPDS EKAKGVEWKRPHEFCAEPQFICEDMSRTDVCQ--GSL--GNCWLLAAAASLTLYPRLLYR VVPPGQGFQD-GYAGVFHFQLWQFGRWVDVVVDDKLPVRD-GKLLFVRSEQRNEFWAPLL EK---AYAKLHGSYEVMRGGHMNEAFVDFTGGVGEVLYLR-Q---NTPGVFAALRHALAK ESLVGATA---------------------------------------------------- ---------LSD------------------------------------------------ -R--GEIRTDEGLVKGHAYSVTGTH-----K-------MSL----GF---TKVRLLRLRN PWG-RVEWSGPWSDS-----------CPRWDMLPSEWRD-ALLVK-KEDGEFWMELQDF- LTHFNTVQICS--LSPEVLGPSPA------GG-GWHIHTFQGRWVRGFN-------SGGS QPS-A-----------ENFWTNPQFRLTLLEPDE---EED----EDDEEGPWGGWGAAGA R-PARGGRVPKCTVLLSLIQRNRRCLRAKGLTYLTVGFHVFQ---I-----P--E----E --LLGLWDSPRSRALLPGLLRADRS-VFCARRDVSRRCRLPPGHYLVVPSASRVGDEAD- -FTLRIFSERSH------TAV--E---IDDVISADLDAL--------------------- ------------------------------------QA---PY-KPLEL-ELAQ---LFL ELA-GE---------------------------------------------EEELNALQL QTL-------------ISIAL-EP------------------------------------ -----------------------------------------ARN-N--TRTSGEIG-LRT CEQLVQCF-G-----RGQRLALYHFQELWGHLLSWQ--------------------ATFD KFDEDASGTMNSCELRLALT---------------------------------------- ------AA----GFHLNNQLTQALTSRYRNS-RLRVDFEHFVCCAARLTCIFRHCCQHLD GGE--GVVCLTHK--Q-WSE-VA--TFS >M_musculus_ENSMUSP00000069055 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MASGNR------------KVTIQLV- -----DDGAGTGAGGPQLFKG-QNYEAIRRACLDSGILFRDPCFPAGPDALGYDKLGPDS EKAKGVEWKRPHEFCAEPQFICEDMSRTDVCQ--GSL--GNCWLLAAAASLTLYPRLLYR VVPPGQGFQD-GYAGVFHFQLWQFGRWVDVVVDDKLPVRE-GKLMFVRSEQRNEFWAPLL EK---AYAKLHGSYEVMRGGHMNEAFVDFTGGVGEVLYLR-Q---NTPGVFAALRHALAK ESLVGATA---------------------------------------------------- ---------LSD------------------------------------------------ -R--GEIRTDEGLVKGHAYSVTGTH-----K-------MSL----GF---TKVRLLRLRN PWG-RVEWSGPWSDS-----------CPRWDMLPSEWRD-ALLVK-KEDGEFWMELQDF- LTHFNTVQICS--LSPEVLGPSPA------GG-GWHIHIFQGRWVRGFN-------SGGS QPS-A-----------ENFWTNPQFRLTLLEPDE---EED----DDDEEGPWGGWGAAGA RGPARGGRVPKCTVLLSLIQRNRRCLRAKGLTYLTVGFHVFQ---I-----P--E----E --LLDLWDSPRSRALLPGLLRADRS-VFCARRDVSRRCRLPPGHYLVVPSASRVGDEAD- -FTLRIFSERSH------TAV--E---IDDVISADLDAL--------------------- ------------------------------------QA---PY-KPLEL-ELAQ---LFL ELA-GE---------------------------------------------EEELNALQL QTL-------------ISIAL-EP------------------------------------ -----------------------------------------ARA-N--TRTPGEIG-LRT CEQLVQCF-G-----RGQRLSLHHFQELWGHLMSWQ--------------------ATFD KFDEDASGTMNSCELRLALT---------------------------------------- ------AA----GFHLNNQLTQSLTSRYRDS-RLRVDFERFVCCAARLTCIFRHCCQHLD GGE--GVVCLTHK--Q-WSE-VA--TFS >M_mulatta_ENSMMUP00000036637 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------QDFEALLAECLRNGCLFEDTSFPATLSSIGSGSLLE-- KLPPRLQWKRPPELHSNPQFYFAKTKRLDLCQ--GMV--GDCWFLAALQALTLHQDILSR VVPLNQSFTE-KYAGIFRFWFWHYGKWVPVVIDDRLPVNEAGQLLFVSSTYKNLFWGALL EK---AYAKLSGSYEDLQSGQVSEALVDFTGGVTMTINLA-E---AHGNLWDILTKATYN RTLIGCQ----------------------------------------------------- ---------THS------------------------------------------------ -G--KEKILENGLVEGHAYTVTGIR-----K-------VTC----KH---RPEYLVKLRN PWG-QVEWKGDWSDS-----------SSKWELLSPKEKI-LLLRK-DNDGEFWMTLQDF- KTHFVLLVICK--LTPGLLSQ-EA------AQ-KWTYTMREGRWEKGST-------AGGR RQLLQ-----------GTFWKNPQFLLSVWRPEE---GR-----RSL------------- ---------RPCSVLVSLLQKPRHRCRKRKPHL-AIGFYLYR---E-----P--DSLPNE --ISWQAQGHSSHHLVLRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCTSEANQKSE- -FILRVFSRKHI------FYA--P---SDKMLSFSLQEI--------------------- ------------------------------------ED---QN-EGQDE-FFTK---FFE KVA-GE---------------------------------------------YPEINAVQL QSI-------------LNQMTWSR------------------------------------ -------------S---------------------------QDF------KSRQIT-VLA IEVPLDLMKD---LNASGTMSIQEFRDLWKQLKLYQ--------------------KVFH KQD-NGSGYLNWEQLRAAMK---------------------------------------- ------EA----GIVLSDDVCQLMLVRYGCP-RLQMGFVSFVHLMLRVENMEDVFQNLTQ DGK--G-IYLQKP--E-FLL-FH--IT- >T_nigroviridis_ENSTNIP00000002316 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------VTRMSAPGTCM------------NILNARS- -----NTKDVGTVTNPERFLD-QDFQTLKRYCQHHRLRYIDDMFPPDRRSIGSGILDP-- SDMARVVWLRPTKLHSNPCFIADGASRFDFGQ--GAL--GNCWFLASIGALTFQKSIFAQ VVPLEQSFDE-ENCGLFHFRFWRFGRWIDVVIDDKLPTID-GRLFFVHSKTREEFWPALL EK---AYAKVCGSYADMNAGSPSEALVDFTGGVHICVQLS-D---PPLNLWELMYRAGNA GSLMGCGTQ--------------------------------------------------- ---------GET------------------------------------------------ -S--TNTVLPNGLVQGHAYTVTGVK-----Q-------VSS----QG---RPVNLVRLWN PWG-QGEWNGDWSDR-----------SPLWSTVSTEDRE-MCLRV-QDNGEFWMKLEDF- RQFYNDLDICC--LCPDFLDD-DA------SC-HWKSYCYEGRWVAGIS-------AGGC LNN-I-----------DSFWINPQYRVKVDELLS---ECSS---GSS------------- ---------DEKTMLVSLMQKPDKRNRRLVHNL-HIGFSVFE---V-----T--D----E SQYKSH-TGKFPDTFFRRNYPVAQSKTYVNAREVMELLALRPGEYLIVPSTFQPNETAS- -YLLTVLSKAET------HIH--E---NSDRHGHDYSEE-ESN----------------- ------------------------------------IP---DD-SEIDKSNETS---VFY EYS-DE---------------------------------------------DDKLDAEQL QKL-------------LNDKV-LK------------------------------------ -----------VQT---------------------------RNL------TTGGFS-TDA CRSMVALM-D---TSVTGNLGQREFSRLWRKIYQYK--------------------DIFF RTDATQTGTLSLNELRNAVT---------------------------------------- ------AA----GKTMSEDMLNLMAVRYGSS-SGVVTLENFVALMLRFDSMNQIFRQLSD GPS----MTVQKY--Q-WMY-LY--MYS >G_aculeatus_ENSGACP00000007505 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MALPGVCM------------SILNARN- -----TKNGYGTFAKPEPFLN-QDYEQLKQYCLIQGVRFIDKMFPPDQRSIGGDVLKP-- ADLSRVEWLRPAKLVPKPSFEVDGISRFDFGQ--GIV--GNCWFLASIGSLTFQQQIFQQ VVPLEQRFDE-KYCGLFHFRFWRFGKWVDVVIDDKLPTIN-GQLIFVQSSDPTEFWPALL EK---AYAKVCGSYSDMNSGTPDEALVDFTGGVHMCIELQ-D---PPGDLWELMCRAGQS KSLMGCGTPQ-------------------------------------------------- ---------GDT------------------------------------------------ -A--GNAVLPNGLVQGHAYAVTGVK-----Q-------MMS----NG---TPVQLVRLWN PWG-ATEWNGAWSDE-----------SSLWQTVSPQNRE-MCLSK-GDDGEFWMNLKDF- CKFYSSLDICS--LCPDFLDG-NS------SC-HWKTAFYEGRWVAGTT-------AGGS MNN-F-----------DSFWTNPQYCFKIDELLS---KCS----TEQ------------- ---------GEKNMLVSLMQKPDKRNRRLVQNL-HIGFSVFE---V-----T--G----E --FKAQ-RGKFPAAFFRRNRPVAQSKSYKNAREVMAFFALKPGEYLIVPSTFSPNETAS- -FILTIVSKGET------HVQ--E---NSGGHGDVQHDIQEPN----------------- ------------------------------------PI---KN-GEEDE-KKRT---MFR QYS-DM---------------------------------------------YEEVDAEKL QRL-------------LNEHV-LK------------------------------------ -----------------------------------------GDM------KSGGFS-IDA CRSMVALM-D---TSITGKLNDEEFVHLWNKVVGYK--------------------DVFF RSDVSQTGTLSLIELRNAIT---------------------------------------- ------AS----GNTINDEILNLMALRYGAS-SGHITLESFISLILRFDRVNQIFRHLSN GKD----MTLREP--E-WLY-LS--MYT