>H_sapiens_ENSP00000361075 -----------------------------------------MYNTVWSMD-R--DD---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------ADWREVMM--------------------------- ------------------------------------------------------------ --------PYS---TELIFYI--------------------------------------- ------------------------------------------------------------ ----------------------------EMD-PP----ALPPKPPK----PMT------- ------------------------------------------------------------ --------------SA-------VPNGMK--DSSVSLQDAEWYWG---DISREEVNDKLR DMP-DGTFLVRDASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFN--- -SVVELINH-YHHESLAQY----------NPKLDVKL---MYPVSRY-QQ---------- --DQ----L-VKE--DNIDAVG-KKLQEYHSQYQEKSKEYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--HTQEQHSKEYIE--- RFRRE---------------GNEKE------IE-RIMMNYDKLKSRLGEIHDSKM----R LE------QDLKNQALDNREIDKKMNSIKP-----DL--IQLRKIRDQHL------VWLN H-KGVRQKRLNVWLGIK-NEDADE--------N-YFINE--E---DENLP-HYDEKTWFV E----------------------------------------------DINRVQAEDLLYG KPDGAFLIRES-SKKGC------------------------------------------- -----------YACSVVADGE-VKH-CV-IYSTARGYGFAEPYNLYS---SLKELVLHYQ QTSLVQHNDSL-----------------------NVRLAYPVH----------------- -----------AQMPSLCR----------------------------------------- -- >P_pygmaeus_ENSPPYP00000001627 -----------------------------------------MYNTVWSMD-R--DD---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------ADWREVMM--------------------------- ------------------------------------------------------------ --------PYS---TELIFYI--------------------------------------- ------------------------------------------------------------ ----------------------------EMD-PP----ALPPKPPK----PMT------- ------------------------------------------------------------ --------------SA-------VPNGMK--DSSVSLQDAEWYWG---DISREEVNDKLR DMP-DGTFLVRDASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFN--- -SVVELINH-YHHESLAQY----------NPKLDVKL---MYPVSRY-QQ---------- --DQ----L-VKE--DNIDAVG-KKLQEYHSQYQEKSKEYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--HTQEQHSKEYIE--- RFRRE---------------GNEKE------IE-RIMMNYDKLKSRLGEIHDSKM----R LE------QDLKKQALDNREIDKKMNSIKP-----DL--IQLRKIRDQHL------VWLN H-KGVRQKRLNVWLGIK-NEDADE--------N-YFINE--E---DENLP-HYDEKTWFV E----------------------------------------------DINRVQAEDLLYG KPDGAFLIRES-SKKGC------------------------------------------- -----------YACSVVADGE-VKH-CV-IYSTARGYGFAEPYNLYS---SLKELVLHYQ QTSLVQHNDSL-----------------------NVRLAYPVH----------------- -----------AQMPSLCR----------------------------------------- -- >P_troglodytes_ENSPTRP00000001190 -----------------------------------------MYNTVWSMD-R--DD---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------ADWREVMM--------------------------- ------------------------------------------------------------ --------PYS---TELIFYI--------------------------------------- ------------------------------------------------------------ ----------------------------EMD-PP----ALPPKPPK----PMT------- ------------------------------------------------------------ --------------SA-------VPNGMK--DSSVSLQDAEWYWG---DISREEVNDKLR DMP-DGTFLVRDASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFN--- -SVVELINH-YHHESLAQY----------NPKLDVKL---MYPVSRY-QQ---------- --DQ----L-VKE--DNIDAVG-KKLQEYHSQYQEKSKEYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--HTQEQHSKEYIE--- RFRRE---------------GNEKE------IE-RIMMNYDKLKSRLGEIHDSKM----R LE------QDLKKQALDNREIDKKMNSIKP-----DL--IQLRKIRDQHL------VWLN H-KGVRQKRLNVWLGIK-NEDADE--------N-YFINE--E---DENLP-HYDEKTWFV E----------------------------------------------DINRVQAEDLLYG KPDGAFLIRES-SKKGC------------------------------------------- -----------YACSVVADGE-VKH-CV-IYSTARGYGFAEPYNLYS---SLKELVLHYQ QTSLVQHNDSL-----------------------NVRLAYPVH----------------- -----------AQMPSLCR----------------------------------------- -- >M_mulatta_ENSMMUP00000040267 -----------------------------------------MYNTVWSMD-R--DD---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------ADWREVMM--------------------------- ------------------------------------------------------------ --------PYS---TELIFYI--------------------------------------- ------------------------------------------------------------ ----------------------------EMD-PP----ALPPKPPK----PMT------- ------------------------------------------------------------ --------------SA-------VTNGMK--DSSVSLQDAEWYWG---DISREEVNDKLR DMP-DGTFLVRDASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFN--- -SVVELINH-YHHESLAQY----------NPKLDVKL---MYPVSRY-QQ---------- --DQ----L-VKE--DNIDAVG-KKLQEYHSQYQEKSKEYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--HTQEQHSKEYIE--- RFRRE---------------GNEKE------IE-RIMMNYDKLKSRLGEIHDSKM----R LE------QDLKKQALDNREIDKKMNSIKP-----DL--IQLRKIRDQHL------VWLN H-KGVRQKRLNAWLGIK-NEDADE--------N-YFINE--E---DENLP-HYDEKTWFV E----------------------------------------------DINRVQAEDLLYG KPDGAFLIRES-SKKGC------------------------------------------- -----------YACSVVADGE-VKH-CV-IYSTARGYGFAEPYNLYS---SLKELVLHYQ QTSLVQHNDSL-----------------------NVRLAYPVH----------------- -----------AQMPSLCR----------------------------------------- -- >C_familiaris_ENSCAFP00000006438 -----------------------------------------MYNTVWSMD-R--DD---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------ADWREVMM--------------------------- ------------------------------------------------------------ --------PYS---TELIFYI--------------------------------------- ------------------------------------------------------------ ----------------------------EMD-PP----ALPPKPPK----PMT------- ------------------------------------------------------------ --------------SA-------ITNGMK--DSSISLQDAEWYWG---DISREEVNDKLR DMP-DGTFLVRDASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFN--- -SVVELINH-YHHESLAQY----------NPKLDVKL---MYPVSRY-QQ---------- --DQ----L-VKE--DNIDAVG-KKLQEYHSQYQEKSKEYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--HTQEQHSKEYIE--- RFRRE---------------GNEKE------IE-RIMMNYDKLKSRLGEIHDSKM----R LE------QDLKKQALDNREIDKKMNSIKP-----DL--IQLRKIRDQHL------VWLN H-KGVRQKRLNAWLGIK-NEDADE--------T-YFINE--E---DENLP-HYDEKTWFV E----------------------------------------------DINRVQAEDLLYG KPDGAFLIRES-SKKGC------------------------------------------- -----------YACSVVADGE-VKH-CV-IYSTARGYGFAEPYNLYS---SLKELVLHYQ QTSLVQHNDSL-----------------------NVRLAYPVH----------------- -----------AQMPSLCR----------------------------------------- -- >B_taurus_ENSBTAP00000003878 -----------------------------------------MYNTVWSMD-R--DD---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------ADWREVMM--------------------------- ------------------------------------------------------------ --------PYS---TELIFYI--------------------------------------- ------------------------------------------------------------ ----------------------------EMD-PP----ALPPKPPK----PMT------- ------------------------------------------------------------ --------------SA-------ITNGIK--DSSVSLQDAEWYWG---DISREEVNDKLR DMP-DGTFLVRDASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFN--- -SVVELISH-YHHESLAQY----------NPKLDVKL---MYPVSRY-QQ---------- --DQ----L-VKE--DNIDAVG-KKLQEYHSQYQEKSKEYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--HTQEQHSKEYIE--- RFRKE---------------GNEKE------IE-RIMMNYDKLKSRLGEIHDSKM----R LE------QDLKKQALDNREIDKKMNSIKP-----DL--IQLRKIRDQHL------VWLN H-KGVRQKRLNAWLGIK-NEDADE--------T-YFINE--E---DENLP-HYDEKTWFV E----------------------------------------------DINRVQAEDLLYG KPDGAFLIRES-SKKGC------------------------------------------- -----------YACSVVADGE-VKH-CV-IYSTARGYGFAEPYNLYG---SLKELVLHYQ RTSLVQHNDSL-----------------------NVRLAYPVH----------------- -----------AQMPSLCR----------------------------------------- -- >R_norvegicus_ENSRNOP00000000157 -----------------------------------------MYNTVWSMD-R--DD---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------ADWREVMM--------------------------- ------------------------------------------------------------ --------PYS---TELIFYI--------------------------------------- ------------------------------------------------------------ ----------------------------EMD-PP----ALPPKPPK----PVT------- ------------------------------------------------------------ --------------SA-------VTNGMK--DCFVSLQDAEWYWG---DISREEVNDKLR DMP-DGTFLVRDASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SEPLTFN--- -SVVELINH-YHHESLAQY----------NPKLDVKL---MYPVSRY-QQ---------- --DQ----L-VKE--DNIDAVG-KNLQEFHSQYQEKSKEYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--HTQEQHSKDYIE--- RFRRE---------------GNEKE------IE-RIMMNYDKLKSRLGEIHDSKV----R LE------QDLKKQALDNREIDKKMNSIKP-----DL--IQLRKIRDQHL------VWLN H-RGVRQRRLNAWLGIK-SEDTDG--------G-YFINE--D---DESLP-HYDEKTWFV E----------------------------------------------DVNRVQAEDLLYG KPDGAFLIRES-SKKGC------------------------------------------- -----------YACSVVADGE-VKH-CV-IYSTARGYGFAEPYNLYG---SLKELVLHYQ QTSLVQHNDSL-----------------------NVTLAYPVH----------------- -----------AQMPSLCR----------------------------------------- -- >M_musculus_ENSMUSP00000030464 -----------------------------------------MYNTVWSMD-R--DD---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------ADWREVMM--------------------------- ------------------------------------------------------------ --------PYS---TELIFYI--------------------------------------- ------------------------------------------------------------ ----------------------------EMD-PP----ALPPKPPK----PMT------- ------------------------------------------------------------ --------------PA-------VTNGMK--DSFISLQDAEWYWG---DISREEVNDKLR DMP-DGTFLVRDASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SEPLTFT--- -SVVELINH-YHHESLAQY----------NPKLDVKL---TYPVSRF-QQ---------- --DQ----L-VKE--DNIDAVG-KNLQEFHSQYQEKSKEYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--HTQEQHSKDYIE--- RFRRE---------------GNEKE------IE-RIMMNYDKLKSRLGEIHDSKL----R LE------QDLKKQALDNREIDKKMNSIKP-----DL--IQLRKIRDQHL------VWLN H-RGVRQRRLNAWLGIK-NEDSDE--------S-YFINE--E---DENLP-HYDEKTWFV E----------------------------------------------DINRVQAEDLLYG KPDGAFLIRES-SKKGC------------------------------------------- -----------YACSVVADGE-VKH-CV-IYSTARGYGFAEPYNLYS---SLKELVLHYQ QTSLVQHNDSL-----------------------NVRLAYPVH----------------- -----------AQMPTLCR----------------------------------------- -- >A_carolinensis_ENSACAP00000015633 -----------------------------------------MYNTVWDMD-R--DD---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TDWREVMM--------------------------- ------------------------------------------------------------ --------PYS---TELIFYI--------------------------------------- ------------------------------------------------------------ ----------------------------EMD-PP----ALPPKPSK----PIT------- ------------------------------------------------------------ --------------PI-------NTNGLKE-NCILSLQDAEWYWG---DISREEVNDKLR DMP-DGTFLVRDASTKKQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFN--- -SVVELINH-YHHESLAQY----------NPKLDVKL---MYPISRY-QQ---------- --DQ----L-VKE--DNIDAVG-KKLQEYHTQYQEKSKEYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--HTQEQYSKEYIE--- RFRRE---------------GNEKE------IE-RIMMNYEKLKSRLGEIHDSKL----R LE------QDLKKQALDNREIDKKMNSIKP-----DL--IQLRKIRDQYL------VWLN H-KGVRQKRINDWLGIK-NENIDD--------T-YFTNE--E---DENLP-HYDEKTWFV G----------------------------------------------DLNRIQAEDLLCG KPDGAFLIRES-SKKGC------------------------------------------- -----------YACSVVADGE-VKH-CV-IYSTPRGYGFAEPYNLYS---TLKELVLHYQ HTSLVQHNDSL-----------------------NVRLAYPVY----------------- -----------AQMSSLCR----------------------------------------- -- >X_tropicalis_ENSXETP00000007065 -----------------------------------------MYNTVWNMD-Q--DD---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------ADWREVMM--------------------------- ------------------------------------------------------------ --------PYS---TELIFYI--------------------------------------- ------------------------------------------------------------ ----------------------------EMD-PP----VLPPKPPK----SMT------- ------------------------------------------------------------ --------------SL-------STDGSK--ENSVSLQDAEWYWG---DISREEVNDKLR DMP-DGTFLVRDASTKVQGDYTLTLR-KG---GNNKLIKIYHQDGKYGF-SDPLTFN--- -SVVELINH-YRNESLAQY----------NPKLDVKL---LYPVSRY-QQ---------- --DQ----L-VKE--DNIDAVG-RKLQEYHGQFQDKSKEYDKLY--EEYTKTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--HTQERYSKEYME--- RFNRE---------------GNEKE------ME-RIIMNYEKLKSRLGEIHDSKL----R LE------QDLKKQALDNREIDKKMNSIKP-----DL--IQLRKIRDQYL------VWLN H-KGVRQKRINDWLGIK-NENIDD--------T-YFVSE--E---DDNLP-HYDEKTWFV G----------------------------------------------DLNRIQAEELLSG KPDGAFLIRES-SKKGC------------------------------------------- -----------YACSVVADGD-VKH-CV-IYSTSRGYGFAEPYNLYS---TLKELVLHYQ HTSLVQHNDSL-----------------------NVRLAYPVY----------------- -----------AQMPSLCR----------------------------------------- -- >T_guttata_ENSTGUP00000008408 ------------------------------------SSDGLQYRALYEYQ-KDREEDLAL ------------------------------------------------------------ -----CPGDVLTVSRAGLLGSPNYKDGDERNPQ--GWLHGVNERTKERGDFPGTYVEYLG PTRIAAAATKARPRPLPLPP--AGTPTPWGLS--G------------------------- ---------------------------QAELTEHPALPEQALQTVARLIEALEKQG-TET H-----GPGCTRSHQLCPVPCVSLPADASAVDMDLYEAQT-LADALKWYLQELPTPLIPP A---LYSDLVHMAQ--E-TPGLEEC--GQR--------------------------ARAL LAPPALPQPQALLLRQLARHFCHLCQ--GSPRSRLSPRLLGELFGELLLRP------VTA ------------------------------------------------------------ -----RTDSHTQYVQG-CEAGIASDPDFEAASPS----TLPPKPSK----PMT------- ------------------------------------------------------------ --------------PV-------NTNGIKD-NSNFSLQEAEWYWG---DISREEVNDKLR DMP-DGTFLVRDASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFN--- -SVVELINH-YRNESLAQY----------NPKLDVKL---MYPVSRY-QQ---------- --DQ----L-VKE--DNIDAVG-KKLQEYHAQYQEKSKEYDKLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--HSQERYSKEYIE--- RFRRE---------------GNDKE------IE-RDMMNYEKLKSRLGEIHDSKM----R LE------QDLKKQALDNRETDKKMNSIKP-----DL--IQLRKIRDQYL------VWLN H-KGVRQKRINDWLGIK-NENIDD--------T-YFVNE--E---DENLP-HHDEKTWFV G----------------------------------------------DLNRVQAEDLLCG KPDGAFLIRES-SKKGC------------------------------------------- -----------YACSVVADGE-VKH-CV-IYSTPRGYGFAEPYNLYS---TLKDLVLHYQ QTSLVQHNDSL-----------------------NVRLAYPVY----------------- -----------AQMPP-------------------------------------------- -- >D_rerio_ENSDARP00000040333 -----------------------------------------MYNTVWNTE-K--ED---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DDWRDVMM--------------------------- ------------------------------------------------------------ --------PYS---TELIFYI--------------------------------------- ------------------------------------------------------------ ----------------------------EMDQPP----ALPPKPTK----PMT------- ------------------------------------------------------------ --------------PV-------NGNGVKE-AASGSLQEAEWYWG---DISREEVNDKLR DMP-DGTFLVRDASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFN--- -SVVELISH-YRHESLAQY----------NTKLDVKL---MYPVSRY-QQ---------- --DQ----L-VKE--DNIDAVG-RKLQEYHNQYQEKSKEYDRLY--EEHTKTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--HTQERYSKEYIE--- RFRRE---------------GNDKE------IE-RIMMNYEKLKSRLGEIHDSKT----R LE------QDLKTQALDNRETDKKMNSLKP-----DL--IQLRKIRDQYL------VWLN H-KGVRQKRINDWLGLK-NETTDD--------A-YFVSE--E---DENLP-HYDEKSWFV G----------------------------------------------DLNRTQSEDLLHG KPDGAFLIRES-SKKGC------------------------------------------- -----------YACSVVVEGE-VKH-CV-IYSTPRGFGFAEPYNLYS---TLKDLVLHYH QTSLVQHNDSL-----------------------NVRLAYPVY----------------- -----------AQMPSGPRR---------------------------------------- -- >G_gallus_ENSGALP00000037576 M----------------------------------ASSEGLQYRALYEYQ-KDRDEDLAL ------------------------------------------------------------ -----SPGDVLTVSRAALLSAPNYKDGDERSPQ--GWLHGLNERTKERGHFPGTYVEYLG P--VCITSTKAKTRPLPPPP--AGTPVPTGQP--WGECG-GLGEQH-------------- ------------------------GHLVAEHAEQPALPEKALLTVARLIEALEKQG-LDS ELLYRSDPGVLGDAELKE----ALLADASDVDMELYDAQT-LAETLKWYLQELPAPLVPP T---LCADLLCIAQ--E-TLSVEEC--GQR--------------------------AQAL LAPPALPQPHTLLLQELIRHFGHLCQ--AACKNRLSAQLLGELFGELLLRP------APS ------------------------------------------------------------ -----STEASPELCARIIESLIVASEAAEVPAAP----ALPPKPSK----PMT------- ------------------------------------------------------------ --------------PV-------NTNGIKD-NSSFSLQEAEWYWG---DISREEVNDKLR DMP-DGTFLVRDASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFN--- -SVVELINH-YRNESLAQY----------NPKLDVKL---MYPVSRY-QQ---------- --DQ----L-VKE--DNIDAVG-KKLQEYHAQYQEKSKEYDKLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--HSQERYSKEYIE--- RFRRE---------------GNEKE------IE-RIMMNYEKLKSRLGEIHDSKM----R LE------QDLKKQALDNRETDKKMNSIKP-----DL--IQLRKIRDQYL------VWLN H-KGVRQKRINDWLGIK-NENIDD--------T-YFVNE--E---EENLP-HHDEKTWFV G----------------------------------------------DLNRIQAEDLLCG KPDGAFLIRES-SKKGC------------------------------------------- -----------YACSVVADGE-VKH-CV-IYSTPRGYGFAEPYNLYS---TLKDLVLHYQ QTSLVQHNDSL-----------------------NVRLAYPVY----------------- -----------AQMPP-------------------------------------------- -- >O_anatinus_ENSOANP00000009424 -----------------------------------------MYNTVWNMD-R--DD---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------ADWREVMM--------------------------- ------------------------------------------------------------ --------PYS---TELIFYI--------------------------------------- ------------------------------------------------------------ ----------------------------EMD-PP----ALPPKPPK----PMT------- ------------------------------------------------------------ --------------PS-------STNEVKD-SSGVALQDAEWYWG---DISREEVNDKLR DMP-DGTFLVRDASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFN--- -SVVELINH-YRHESLAQY----------NPKLDVKL---MYPVSRY-QQ---------- --DQ----L-VKE--DSIDAVG-KKLQEYHAQYQEKSKEYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--HTQERYSKEYIE--- RFRRE---------------GNEKE------IE-RIMMNYEKLKSRLGEIHESKM----R LE------QDLKKQALDNREIDKKMNSIKP-----DL--IQLRKIRDQYL------VWEK K-MGRPQRRERRGLASS-WDGNDP--------T-YFVNE--E---DENLP-HYDEKTWFV G----------------------------------------------DLNRTQAEDLLRG KPDGAFLIRES-SKKGC------------------------------------------- -----------YACSVVADGE-VKH-CV-IYSTPRGYGFAEPYNLYG---TLKELVLHYQ QTSLVQHNDSL-----------------------NVRLAYPVY----------------- -----------AQMPALGR----------------------------------------- -- >G_aculeatus_ENSGACP00000006864 -----------------------------------------MYNTVWTTE-QTGEE---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GDWRDVVM--------------------------- ------------------------------------------------------------ --------PYS---TELIFYL--------------------------------------- ------------------------------------------------------------ ----------------------------EMDQPP----ALPPKPAK----PQQ------- ------------------------------------------------------------ --------------PCSVGTGGGSGNGTKDGGAGGSLQEAEWYWG---DISREEVNDKLR DMP-DGTFLVRDASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFS--- -SVVELINH-YRHESLAQY----------NTKLDVKL---VYPISRF-QQ---------- --DQ----L-VKE--DNIDAVG-KKLQEYHNQYQEKNKEYDRLY--EEYTKTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--HTQERYSKDYIE--- RFRRE---------------GNDKE------IE-RIMMNYEKLKSRLGEIHDSKV----R LE------QDLKTQAMDNRETDKKMNSLKP-----DL--IQLRKIRDQYL------VWLN H-KGVRQKRINDWLGIK-NENTDE--------G-YFVSE--E---DENLP-HYDEKSWFV G----------------------------------------------DLNRTEAEDLLTG KPDGAFLIRES-SKKGC------------------------------------------- -----------YACSVIVEGE-VKH-CV-IYSTPRGFGFAEPYNLYS---SLKDLVLHYR QASLVQHNDSL-----------------------NVRLAYPVY----------------- -----------AQMPSGRR----------------------------------------- -- >O_cuniculus_ENSOCUP00000012307 -----------------------------------------MYNTVWSMD-R--DD---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------ADWREVMM--------------------------- ------------------------------------------------------------ --------PYS---TELIFYI--------------------------------------- ------------------------------------------------------------ ----------------------------EMD-PP----XXXXXXXX----XXX------- ------------------------------------------------------------ --------------XX-------XXXXXX--XXXXXXXXXXXXXX---XXXXXXXXXXXX XXX-XXXXXXXXXXXXXXXXXXXXXX-KG---GNNKLIKIYHRDGKYGF-SDPLTFN--- -SVVELINH-YHHESLAQY----------NPKLDVKL---MYPVSRY-QQ---------- --DQ----L-VKE--DNIDAVG-KKLQEYHSQYQEKSKEYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--HTQEQHSKEYIE--- RFRRE---------------GNEKE------IE-RIMMNYDKLKSRLGEIHDSKM----R LE------QDLKKQALDNREIDKKMNSIKP-----DL--IQLRKIRDQHL------VWLN H-KGVRQKRLNAWLGIK-NEDADE--------T-YFINE--E---DENLP-HYDEKTWFV E----------------------------------------------DINRVQAEDLLYG KPDGAFLIRES-SKKGC------------------------------------------- -----------YACSVVADGE-VKH-CV-IYSTARGYGFAEPYNLYS---SLKELVLHYQ HTSLVQHNDSL-----------------------NVRLAYPVH----------------- -----------AQMPSLCR----------------------------------------- -- >O_latipes_ENSORLP00000016725 G----------------------------------FSQTKAMYNTVLTTE-KADEE---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GDWRDMTM--------------------------- ------------------------------------------------------------ --------PYS---TELIFYL--------------------------------------- ------------------------------------------------------------ ----------------------------EMDQPP----ALPPKPAK----SQQ------- ------------------------------------------------------------ --------------SSSVGV---GGGSTTT-KDGGALQEAEWYWG---DISREEVNDKLR DMP-DGTFLVRDASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SEPLTFN--- -SVVDLISH-YRHESLAQY----------NTKLDVKL---MYPVSRF-QQ---------- --DQ----L-VKE--DNIDAVG-KKLQEYHNQYQDKSKDYDRLY--EDYTKTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--HTQERYSKDYIE--- RFHRE---------------GNDKE------IE-RIMMNYEKLKSRLGEIHDSKV----R LE------QDLKTQAMDNRETDKKMNSLKP-----DL--IQLRKIRDQYL------VWLN H-KGVRQKRINDWLGLK-NENTDE--------S-SFVSE--E---EENLP-HYDEKSWFV G----------------------------------------------NLNRMEAEELLIG KSDGVFLIRES-SKKGC------------------------------------------- -----------YACSVVVDGE-VKH-CV-IYSTPRGFGFAEPYNLYS---SLKDLVLHYQ QTSLVQHNDSL-----------------------NVRLAYPVY----------------- -----------TQMPSGRR----------------------------------------- -- >G_gorilla_ENSGGOP00000009961 -----------------------------------------MYNTVWSMD-R--DD---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------ADWREVMM--------------------------- ------------------------------------------------------------ --------PYS---TELIFYI--------------------------------------- ------------------------------------------------------------ ----------------------------EMD-PP----ALPPKPPK----PMT------- ------------------------------------------------------------ --------------SA-------VPNGMK--DSSVSLQDAEWYWG---DISREEVNDKLR DMP-DGTFLVRDASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFN--- -SVVELINH-YHHESLAQY----------NPKLDVKL---MYPVSRY-QQ---------- --DQ----L-VKE--DNIDAVG-KKLQXXXXXXXXXXXXXXXXX--XXXXXXX------- -----XEIQMKR------------TAI--EAFNETIKIFEEQC--HTQEQHSKEYIE--- RFRRE---------------GNEKE------IE-RXXXXXXXXXXXXXXXXXXXX----X XX------XXXXXXXXXXXXXXXXXXXXXX-----XX--XXXXXXXXXXX------XWLN H-KGVRQKRLNVWLGIK-NEDADE--------N-YFINE--E---DENLP-HYDEKTWFV E----------------------------------------------DINRVQAEDLLYG KPDGAFLIRES-SKKGC------------------------------------------- -----------YACSVVADGE-VKH-CV-IYSTARGYGFAEPYNLYS---SLKELVLHYQ QTSLVQHNDSL-----------------------NVRLAYPVH----------------- -----------AQMPSLCR----------------------------------------- -- >T_rubripes_ENSTRUP00000000305 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------FCF--------------------------------------- ------------------------------------------------------------ ----------------------------SFS-RP----ALPPKPMR----PQQ------- ------------------------------------------------------------ --------------PSSEG----VGGGTK--DGAGSLQEAEWYWG---DISREEVNDKLR DTP-DGTFLVRDASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFS--- -SVVELIGH-YRHESLAQY----------NTKLDVKL---MFPISRF-QQ---------- --DQ----L-VKE--DNIDAVG-KKLQEYHCQYQDRNKEYDRLY--EEYTKTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--HTQERYSKDHIE--- RFCRE---------------CNDKE------ME-RILVNYEKLKSRLSEIHDSKV----R LE------QDLKTQAMDIRETDKKMNSLKP-----DL--IQLRKIRDQHL------VWLN H-KGVRQKRINDWLGIK-NENPDE--------G-SCLSQ--E----ENLP-HHDEKSWFV G----------------------------------------------DLNRTQAEELLQG KPDGAFLIRES-SKKSC------------------------------------------- -----------YACSVVVEGE-VKH-CV-VLSTPRGFGFAEPFNLYS---SLKELVLHYQ QASLVQHNDSL-----------------------NVRLSYPVY----------------- -----------AQMPPGRR----------------------------------------- -- >T_rubripes_ENSTRUP00000027602 A----------------------------------MSSEGFQYRALYDYK-KEREEDIDL ------------------------------------------------------------ -----HVGDVLLVSRGALLALG-CSSGAEERPSEIGWLPGFNETTQEKGDFPGTYVEFIG RKRMSPPTPKPR----PPRP------PS-ASA--RADSE-SD------------------ ------------------------GFVLPDLAEQFGPPDTAPPLLTRLMEAIENKG-LDA PVC---------CDVSLLLNT----GVFVFSDLEQLDLLS-LCCGVLRFLQDLPGPILPS I---LQADMIRAVQ--E-VRDVEDC--AQV--------------------------LRCI ASSSSCPAQYGLTLLSVVRHLARVCL--HGSRNQLSPRTLAESFSPVLFRL------SAG SFPQPYRSES-------------------------------------------------- ---------SLDPLVQVLEILITSELNMNQ-AAPVFSPALPPKPVK----CST------- ------------------------------------------------------------ --------------PA-------PPSSFN---NSISLQDAEWYWG---DISREEVNEKLR DTA-DGTFLVRDASTKMHGDYTLTLR-KG---GNNKLIKIFHREGKYGF-SDPLTFS--- -SVVELINH-YRHESLAQY----------NPKLDVKL---LYPVSKH-QQ---------- --DQ----V-VKE--DSIEAVG-KKLHEYHLQYQEKNREYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--QTQERFSKEYID--- KFRRE---------------GNDKE------IQ-RIMENYDKLKSRISEIVDSKR----H LE------VDLKKQAADYREIDKKMNSIKP-----DL--IQLRKTRDQYL------MWLT Q-KGVRQRKLNEWLGLK-NETTED--------E-YSMVE--D---EEDLP-HHDERLWRL G----------------------------------------------NINRTQAESLLRG KRDGTFLVRDS-SKAGC------------------------------------------- -----------YACSVVVDGE-VKH-CV-INKTSTGFGFAEPYNLYA---SLKELVLHYQ HTSLFQHNDSL-----------------------NVTLAFPVY----------------- -----------RSGPGPQSGPK-------------------------------------- -- >T_nigroviridis_ENSTNIP00000022063 -----------------------------------MSSEGFQYRALYDYK-KEREEDIDL ------------------------------------------------------------ -----HVGDVLLVSRGALLALG-CSSGAEERPSEIGWLPGFNETTQEKGDFPGTYVEFIG RKRMSPPTPKPR----PPRP------PS-ASA--RADSE-SE------------------ ------------------------GSLLPDLAEQFGPPDTAPPLLTRLMEAIENRG-LEA PGVYQGLSAGG-LDVRQLADAVRSRWDASLTDLEQLDVPS-LCCGVVRFLQDLPGPILPS V---LQADMIRAVQ--E-VRDLEDC--AQV--------------------------LRCV ASSSSCPAQHGLTLLSLVRHLARLCL--HGSRNQLSPRSLAESFSPVLFRH------SSG -------SES-------------------------------------------------- ---------SLDLLVQVLEVLITSELNMNQ-AAP-FPSALPPKPVK----CST------- ------------------------------------------------------------ --------------PA-------PPSSFN---NSISLQDAEWYWG---DISREEVNEKLR DTA-DGTFLVRDASTKMHGDYTLTLRWKG---GNNKLIKIFHREGKYGF-SDPLTFS--- -SVVELINH-YRHESLAQY----------NPKLDVKL---LYPVSKH-QQ---------- --DQ----V-V-E--DSIEAVG-KKLHEYHLQYQEKNREYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--QTQERFSKEYID--- KFRRE---------------GNDKE------IQ-RIMENYDKLKSRISEIVDSKR----H LE------VDLKKQAADYREIDKKMNSIKP-----DL--IQLRKTRDQYL------MWLT Q-KGVRQRKLNEWLGLK-NETTED--------E-YSMVE--D---EEDLP-HHDERLWRL G----------------------------------------------NINRTQAESLLRG KRDGTFLVRDS-SKAGC------------------------------------------- -----------YACSVVVDGE-VKH-CV-INKTSTGFGFAEPYNLYA---SLKELVLHYQ HTSLVQHNDSL-----------------------NVTLAFPVY----------------- -----------SPQRR-------------------------------------------- -- >T_rubripes_ENSTRUP00000018794 ----------------------------------RMSAEGYQYRALYEYK-KEREEDIDL ------------------------------------------------------------ -----HVGDILLVSKAALVALG-YGDGMELRPEGIGWLPGFNETTQEKGDFPGTYVEFVG KKWLSPPTPKPR----PLRP--LPLAPADSLLSYPP------------------------ ------------------------GFSLPDLTEQFSLPETSPPMLARLLEAIERKG-LDN PTLYRTFTASGGLE------------DAPSADLDQLELPV-LCDGLHRYLQDLPLPIIPP A---VYPQMVHTAK--E-VVSPEEC--AQL--------------------------LRHI ASTPSLPPQYWLTIHCLIRHFSRVCQ--NCTKNLLSARAVGEIFSPMVFRQ------QSA -------SSS-------------------------------------------------- -VPVHSCEPSLDCHIKIIEVLVTSEMSENQ-AAP--VAALPPKPPK----PTP------- ------------------------------------------------------------ --------------V--------TNNGMN---NNMALQDAEWYWG---DISREEVNEKLR DTA-DGTFLVRDASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFS--- -SVVELINH-YRNESLAQY----------NPKLDVKL---LYPVSKH-QQ---------- --DQ----V-VKE--DNIEAVG-RKLCEYHQQYQEKNKEYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--QTQERYSKEYIE--- KFRRE---------------GNEKE------IQ-RIMGNYEKLKSRISEIVDSKR----R LE------EDLKKQAADYREIDKRMNSIKP-----DL--IQLRKTRDQYL------LWLT Q-KGVRQKKLNEWLGIK-NENTED--------Q-YSMVE--D---DEDLP-HQDERSWKL G----------------------------------------------KINRLQAEALLQG KRGGTFLVRDS-SKAGC------------------------------------------- -----------YACSVVVDGE-VKH-CV-INKTPSGYGFAEPYNLYS---SLKELVLHYQ HTSLVQHNDSL-----------------------NVTLAHPVY----------------- -----------AQQKRPPPPAE-------------------------------------- -- >D_rerio_ENSDARP00000056212 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDL ------------------------------------------------------------ -----HVGDILTVNKGALLALG-YMEGMEERPDEVGWLPGFNETTQEKGDFPGTYVEFIG KKKISPPTPKPR----PPRP--LPVAPGPTRQ--DSDSE-QS------------------ ------------------------LSTLLDLTEQFAPPEVAPSMLLKLLEAIEKKG-LDN PTLYRNFTAGGGLDVRQCFD-----SDPASVDLEQMDLQM-LCDGLRRYLQDLPQPVIPP V---IYNEMIRIAQ--E-VQGTDEC--AQH--------------------------LRLV ASSTALPPQYWLTLQSLLRHFSHVCQ--SSAVNLLSARALAEIFSPALFRH------QPT ------------------------------------------------------------ -----SCEPSPEAHIRIIEVLVTSEWSDSQ-AAP----ALPPKPPK----PTS------- ------------------------------------------------------------ --------------V--------ANNGMN---NNMALQDAEWYWG---DISREEVNEKLR DTA-DGTFLVRDASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFN--- -SVVELINH-YRTESLAQY----------NPKLDVKL---LYPVSKH-QQ---------- --DQ----V-VKE--DNIEAVG-KKLHEYHQQFQEKNREYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--QTQERYSKEYIE--- KFRRE---------------GNEKE------IQ-RIMVNYEKLKSRISEIVDSKR----R LE------EDLKKQAADYREIDKRMNSIKP-----DL--IQLRKTRDQYL------MWLT Q-KGVRQKKLNEWLGIK-NENQDD--------Q-YSMVE--D---DEDLP-HHDERSWKL G----------------------------------------------NINRIQAEALLRG KRDGTFLVRDS-SKAGC------------------------------------------- -----------YACSVVVDGE-VKH-CV-INKTPTGYGFAEPYNLYN---SLKELVLHYQ HTSLVQHNDSL-----------------------NVTLAYPVY----------------- -----------GHQRR-------------------------------------------- -- >O_latipes_ENSORLP00000021829 -----------------------------------MSSEGFQYRALYDYK-KEREEDIDL ------------------------------------------------------------ -----HVGDMLLVSKGALLALG-CSNGAEERPSEIGWLPGFNETTQEKGDFPGTYVEFVG RKRISPPTPKPR----PPRP------PSAAST--RTDSE-SE------------------ ------------------------SFVLPDLPEQFGPPDTAPPLLSRLMEAVEARG-SER KPLFVTFSVCGEGEGKTA--GLRLTDVRLFSDLEQLEVPS-LCDGVIRFLLDLPGPVLPP Q---LQGEMVHAVQ--EAVKTSCPT--AQV--------------------------LRAV ASSAACPAQYGLTLLSVVRHLARLCL--HATRNQLSPRMLGELFSPLLFRL------AAG -------SES-------------------------------------------------- ---------GPDPLVQVLEVLITSELNMNQ-AAP----ALPPKPPK----TPT------- ------------------------------------------------------------ --------------PA-------ASSSFN---NSMALQDAEWYWG---DISREEVNEKLR DTA-DGTFLVRDASTKMHGDYTLTLR-KG---GNNKLIKIFHREGKYGF-SDPLTFS--- -SVVELINH-YRHESLAQY----------NPKLDVKL---LYPVSKH-QQ---------- --DQ----V-VKE--DSIEDVG-KKLHEYHLQYQEKNREYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--QTQERFSKEYIE--- KFRRE---------------GNEKE------IQ-RIMENYDKLKSRISDIVDSKR----H LE------ADLKKQAADYREIDKKMNSIKP-----DL--IQLRKTRDQYL------MWLT Q-KGVRQRKLNEWLGLK-NETTED--------E-YSMVE--D---EEDLP-HHDERLWRL G----------------------------------------------NINRGQAEALLRG KRDGTFLVRDS-SKPGC------------------------------------------- -----------YACSVVVEGE-VKH-CV-INKTSTGFGFAEPYNLYG---SLKELVLHYQ HTSLVQHNDSL-----------------------NVTLAFPVY----------------- -----------SQQRR-------------------------------------------- -- >M_mulatta_ENSMMUP00000015140 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDL ------------------------------------------------------------ -----HLGDILTVNKGSLVALG-FSDGQEARPEEIGWLNGYNETTGERGDFPGTYVEYIG RKKISPPTPKPR----PPRP--LPVAPGSSKT--EADVE-QQ------------------ ------------------------ALTLPDLAEQFAPPDVAPPLLIKLVEAIEKKG-LEC STLYRTQSSGNLAELRQLLD-----CDTASVDLEMIDVHI-LADAFKRYLLDLPNPVIPA A---VYSEMISLAQ--E-VQSSEEY--IQL--------------------------LKKL IRSPSIPHQYWLTLQYLLKHFFKLSQ--TSSKNLLNARVLSEIFSPMLFRF------SAA -------SSD-------------------------------------------------- ---------NTENLIKVIEILISTEWNERQ-PAP----ALPPKPPK----PTT------- ------------------------------------------------------------ --------------V--------ANNGMN---NNMSLQDAEWYWG---DISREEVNEKLR DTA-DGTFLVRDASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFN--- -SVVELINH-YRNESLAQY----------NPKLDVKL---LYPVSKY-QQ---------- --DQ----V-VKE--DNIEAVG-KKLHEYNTQFQEKSREYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--QTQERYSKEYIE--- KFKRE---------------GNEKE------IQ-RIMHNYDKLKSRISEIIDSRR----R LE------EDLKKQAAEYREIDKRMNSIKP-----DL--IQLRKTRDQYL------MWLT Q-KGVRQKKLNEWLG---NENTED--------Q-YSLVE--D---DEDLP-HHDEKTWNV G----------------------------------------------SSNRNKAENLLRG KRDGTFLVRES-SKQGC------------------------------------------- -----------YACSVVVDGE-VKH-CV-INKTATGYGFAEPYNLYS---SLKELVLHYQ HTSLVQHNDSL-----------------------NVTLAYPVY----------------- -----------AQQRR-------------------------------------------- -- >R_norvegicus_ENSRNOP00000026210 M----------------------------------AGAEGFQYRAVYPFR-RERPEDLEL ------------------------------------------------------------ -----LPGDLLVVSRVALQALG-VADGGERCPHNVGWMPGFNERTRQRGDFPGTYVEFLG PVALARPGPRPR----GPRP--LPARPLDGPS--ES------------------------ ------------------------GHTLASLAEQFSPPEPAPPILVKLIEAIEQAE-LDS ECYSRPELP----APR---------TDWSLSDLEQWDRTT-LYDAVKGFLLALPAAVVTP E---AASEAYRAMRE---VTGP----------------------------------VGLV LEPPTLPLHQALTLQFLLQHLGRVAR--RAPSPATAVHALASAFGPLLLRA------PPP -------GGE-------------------------------------------------- ---GDGSEPAPDFPVLLLERLVQEHVDEQDTAPP----ALPPKPSK----VKP------- ------------------------------------------------------------ --------------A--------PTALANG-GSTPSLQDAEWYWG---DISREEVNERLR DTP-DGTFLVRDASSKIQGEYTLTLR-KG---GNNKLIKVFHRDGHYGF-SEPLTFC--- -SVVELISH-YRHESLAQY----------NAKLDTRL---LYPVSKY-QQ---------- --DQ----V-VKE--DSVEAVG-AQLKVYHQQYQDKSREYDQLY--EEYTRTS------- -----QELQMKR------------TAI--EAFNETIKIFEEQG--QTQEKCSKEYLE--- RFRRE---------------GNEKE------MQ-RILLNSERLKSRIAEIHESRT----K LE------QDLRAQASDNREIDKRMNSLKP-----DL--MQLRKIRDQYL------VWLT Q-KGARQRKINEWLGIK-NE-TED--------Q-YSLME--D---EDALP-HHEERTWYV G----------------------------------------------KINRTQAEEMLSG KRDGTFLIRES-SQRGC------------------------------------------- -----------YACSVVVDGD-TKH-CV-IYRTATGFGFAEPYNLYG---SLKELVLHYQ HASLVQHNDAL-----------------------TVTLAHPVR----------------- -----------APGPGPPPAAR-------------------------------------- -- >G_aculeatus_ENSGACP00000020881 -----------------------------------MSAEGYQYRALYDYK-KEREEDISL ------------------------------------------------------------ -----HVGDILLVSKGELVALG-YTDGLEQRPDEIGWLPGFNETTLEKGDFPGTYVEFIG RKRISPPTPKPR----PLRP--LPEAPGGFRADTDSDSEQ-------------------- ------------------------GFCLLDLTEQFSPPETSPPMMARLLEAIEKKG-LDN PTLYRTFTAGGGLEVRQFYD-----CDPASPDLDQVELPV-LCDGLRRYLQDLPQPVIPA A---LHPQMVHTAK--E-VGNPEEC--AQL--------------------------LRRV GSTPSLPPQYWLTLHCLLRHFSRVCL--NSSKNLLSARALGEIFSAVLFRQ------QAS -------RWV-------------------------------------------------- ---------QTDRHIKIIEVLVMSECSESQ-AAP----ALPPKPPKPAPAPAP------- ------------------------------------------------------------ --------------A--------TNNGMN---NNMALQDAEWYWG---DISREEVNEKLR DTA-DGTFLVRDASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFS--- -SVVELINH-YRNESLAQY----------NPKLDVKL---QFPVSKH-QQ---------- --DQ----V-VKE--DNIEAVG-RKLCEYHQQFQEKNKEYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--QTQERYSKEYIE--- KFRRE---------------GNDKE------IQ-RIMGNYEKLKSRISEIVDSKR----R LE------EDLKKQAADYREIDKRMNSIKP-----DL--IQLRKTRDQYL------TWLT Q-KGVRQKKLNEWLGIK-NENTED--------Q-YSMVD--D---DEDLP-HHDERSWKL G----------------------------------------------NINRPQAEALLQG KRDGTFLVRDS-SKAGC------------------------------------------- -----------YACSVVVEGE-VKH-CV-INKTSSGLGFAEPYNLYG---SLKELVLHYQ HTSLVQHNDSL-----------------------NVTLAYPVY----------------- -----------TQQRR-------------------------------------------- -- >G_aculeatus_ENSGACP00000001371 -----------------------------------MSSEGFQYRALYDYK-KEREEDIDL ------------------------------------------------------------ -----RVGDMLLVSRGALLALG-CVGGAEERPSEIGWLPGVNETTQEKGDFPGTYVEFIG RKRMSPPTPKPR----PQRP------GSAASV--RMDSE-SE------------------ ------------------------GFTMPDLPEQFAPPDSAPPLLTRLMEAIEAKGSLEN LDVYRGVTGGG-LDTRELADA-EYVGVRLFSDLEQLEVSS-LCDGVIRFLQDLPGPVLPS S---LQTDMIHAVQ--E-VRDLEEC--AQL--------------------------LRSV ASSPSFPAQYGLTLLSVVRHLARLCL--YGSRTQLSPRSLAETFSPFLFRP------PAG -------FEP-------------------------------------------------- ---------SLDPLVQVLEVLITSELNMVQ-AAP----ALPPKPIK----SSS------- ------------------------------------------------------------ --------------PA-------ASCSFN---NSISLQDAEWYWG---DISREEVNEKLR DTA-DGTFLVRDASTKMHGDYTLTLR-KG---GNNKLIKIFHREGKYGF-SDPLTFS--- -SVVELINH-YRHESLAQY----------NPKLDVKL---LYPVSKHQQQ---------- --DQ----V-VKE--DSIEAVG-KKLHEYHLQFQEKNREYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--QTQERFSKEYIE--- KFRRE---------------GNDKE------IQ-RIIENYDKLKSRISEIVDSKR----H LE------VDLKKQAADYREIDKKMNSIKP-----DL--IQLRKTRDQYL------MWLT Q-KGVRQRKLNEWLGLK-NETVEE--------QRVQHGE--D---EEDLP-HHDERLWRL G----------------------------------------------S-TRLQAESLLRG KRDGSFLVRDS-SKPGC------------------------------------------- -----------YACSVVVDGE-VKH-CV-INKTSTGFGFAEPYNLYG---SLKELVLHYQ HTSLVQHNDSL-----------------------NVTLAFPVY----------------- -----------SQPRR-------------------------------------------- -- >O_cuniculus_ENSOCUP00000004433 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------STLPDLAEQFAPPDVAPPLLIKLLEAIEKKG-LEC STLYRTRSSSNPAELRQLL-------CAASVDLEAMDVQV-LADAFKRYLLDLPNPVIPV A---VYSEMLSLAQ--E-IQSAEEY--TQV--------------------------LKKL IRSPNIPHQYWLTLQYLLKHFFRLSQ--ASSKSLLTARALAEIFSPMLFRF------PAA -------SPD-------------------------------------------------- ---------YREHLVKVIEXXXXXXXXXXX-XXX----XLPPKPPK----PTT------- ------------------------------------------------------------ --------------V--------ANNGTN---NNMSLQDAEWYWG---DISREEVNEKLR DTA-DGTFLVRDASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFN--- -SVVELINH-YRNESLAQY----------NPKLDVKL---LYPVSKY-QQ---------- --DQ----V-VKE--DNIEAVG-KKLHEYNTQFQEKSREYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--QTQERYSKEYIE--- KFKRE---------------GNEKE------IQ-RIMHNYDKLKSRISEIIDSRR----R LE------EDLKKQAAEYREIDKRMNSIKP-----DL--IQLRKTRDQYL------MWLT Q-KGVRQKKLNEWLG---NENTED--------Q-YSLVE--D---DEDLP-HHDEKTWNV G----------------------------------------------SSNRNKAETLLRG KRDGTFLVRES-SKQGC------------------------------------------- -----------YACSVVVDGE-VKH-CV-INKTATGYGFAEPYNLYS---SLKELVLHYQ HTSLVQHNDSL-----------------------NVTLAYPVY----------------- -----------AQQRR-------------------------------------------- -- >P_troglodytes_ENSPTRP00000029009 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDL ------------------------------------------------------------ -----HLGDILTVNKGSLVALG-FSDGQEARPEEIGWLNGYNETTGERGDFPGTYVEYIG RKKISPPTPKPR----PPRP--LPVAPGSSKT--EADVE-QQ------------------ ------------------------ALTLPDLAEQFAPPDIAPPLLIKLVEAIEKKG-LEC STLYRTQSSSNLAELRQLLD-----CDTPSVDLEMIDVHV-LADAFKRYLLDLPNPVIPA A---VYSEMISLAP--E-VQSSEEY--IQL--------------------------LKKL IRSPSIPHQYWLTLQYLLKHFFKLSQ--TSSKNLLNARVLSEIFSPMLFRF------SAA -------SSD-------------------------------------------------- ---------NTENLIKVIEILISTEWNERQ-PAP----ALPPKPPK----PTT------- ------------------------------------------------------------ --------------V--------ANNGMN---NNMSLQDAEWYWG---DISREEVNEKLR DTA-DGTFLVRDASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFN--- -SVVELINH-YRNESLAQY----------NPKLDVKL---LYPVSKY-QQ---------- --DQ----V-VKE--DNIEAVG-KKLHEYNTQFQEKSREYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--QTQERYSKEYIE--- KFKRE---------------GNEKE------IQ-RIMHNYDKLKSRISEIIDSRR----R LE------EDLKKQAAEYREIDKRMNSIKP-----DL--IQLRKTRDQYL------MWLT Q-KGVRQKKLNEWLG---NENTEENFLSCLPSQ-YSLVE--D---DEDLP-HHDEKTWNV G----------------------------------------------SSNRNKAENLLRG KRDGTFLVRES-SKQGC------------------------------------------- -----------YACSVVVDGE-VKH-CV-INKTATGYGFAEPYNLYS---SLKELVLHYQ HTSLVQHNDSL-----------------------NVTLAYPVY----------------- -----------AQQRR-------------------------------------------- -- >E_caballus_ENSECAP00000017836 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDL ------------------------------------------------------------ -----HLGDILTVNKGSLVALG-FCDGQEARPEEIGWLNGYNETTGERGDFPGTYVEYIG RKKISPPTPKPR----PPRP--LPVAPGSSKT--EADSE-QQ------------------ ------------------------ALTLPDLAEQFAPPDIAPPLLIKLVEAIEKKG-LEC PTLYRTQSSSNLAELRQLLD-----CDAASLDLEMIDVQV-LADAFKRYLLDLPNPVIPV A---VYSEMISLAP--E-VQSSEEY--IQL--------------------------LKKL IRSPNIPHQYWLTLQYLLKHFFKLTQ--TSSKNLLNARVLSELFSPLLFRF------PAA -------SSE-------------------------------------------------- ---------NSEHLIKVIEILISTEWNERQ-PAP----ALPPKPPK----PTT------- ------------------------------------------------------------ --------------V--------ANNGMN---NNMSLQDAEWYWG---DISREEVNEKLR DTA-DGTFLVRDASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFN--- -SVVELINH-YRNESLAQY----------NPKLDVKL---LYPVSKY-QQ---------- --DQ----V-VKE--DNIEAVG-KKLHEYNTQFQEKSREYDRLY--EDYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--QTQERYSKEYIE--- KFKRE---------------GNEKE------IQ-RIMHNYEKLKSRISEIVDSRR----R LE------EDLKKQAAEYREIDKRMNSIKP-----DL--IQLRKTRDQYL------MWLT Q-KGVRQKKLNEWLG---NENTED--------Q-YSLVE--D---DEDLP-HHDEKTWNV G----------------------------------------------SSNRNKAENLLRG KRDGTFLVRES-SKQGC------------------------------------------- -----------YACSVVVDGE-VKH-CV-INKTATGYGFAEPYNLYS---SLKELVLHYQ HTSLVQHNDSL-----------------------NVTLAYPVY----------------- -----------AQQRR-------------------------------------------- -- >H_sapiens_ENSP00000379855 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDL ------------------------------------------------------------ -----HLGDILTVNKGSLVALG-FSDGQEARPEEIGWLNGYNETTGERGDFPGTYVEYIG RKKISPPTPKPR----PPRP--LPVAPGSSKT--EADVE-QQ------------------ ------------------------ALTLPDLAEQFAPPDIAPPLLIKLVEAIEKKG-LEC STLYRTQSSSNLAELRQLLD-----CDTPSVDLEMIDVHV-LADAFKRYLLDLPNPVIPA A---VYSEMISLAP--E-VQSSEEY--IQL--------------------------LKKL IRSPSIPHQYWLTLQYLLKHFFKLSQ--TSSKNLLNARVLSEIFSPMLFRF------SAA -------SSD-------------------------------------------------- ---------NTENLIKVIEILISTEWNERQ-PAP----ALPPKPPK----PTT------- ------------------------------------------------------------ --------------V--------ANNGMN---NNMSLQDAEWYWG---DISREEVNEKLR DTA-DGTFLVRDASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFS--- -SVVELINH-YRNESLAQY----------NPKLDVKL---LYPVSKY-QQ---------- --DQ----V-VKE--DNIEAVG-KKLHEYNTQFQEKSREYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--QTQERYSKEYIE--- KFKRE---------------GNEKE------IQ-RIMHNYDKLKSRISEIIDSRR----R LE------EDLKKQAAEYREIDKRMNSIKP-----DL--IQLRKTRDQYL------MWLT Q-KGVRQKKLNEWLG---NENTEENFLSCLPSQ-YSLVE--D---DEDLP-HHDEKTWNV G----------------------------------------------SSNRNKAENLLRG KRDGTFLVRES-SKQGC------------------------------------------- -----------YACSVVVDGE-VKH-CV-INKTATGYGFAEPYNLYS---SLKELVLHYQ HTSLVQHNDSL-----------------------NVTLAYPVY----------------- -----------AQQRR-------------------------------------------- -- >C_familiaris_ENSCAFP00000011322 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDL ------------------------------------------------------------ -----HLGDVLTVNKGSLVALG-FSDGQEARPEEIGWLNGYNETTGERGDFPGTYVEYIG RKKISPPTPKPR----PPRP--LPVAPGSSKA--EADCEQQQ------------------ ------------------------ALALPDLAEQFAPPDIAPPLLVKLLEAIEKKG-LEC STLYRTPSSSNPAELRQLLD-----CDAASTDLEMIDVQV-LGDAFKRYLMDLPNPVIPV A---VYNEMIYLAQ--E-VQSSEEY--IQL--------------------------LKKL IRAPTIPHQYWLTLQYLLKHFFKLSQ--TSSKNLLSARVLSELFSPLLFRF------PAA -------SSE-------------------------------------------------- ---------NTEHLIKVIEILISTEWNERQ-PAP----ALPPKPPK----PTT------- ------------------------------------------------------------ --------------V--------ANNGMN---NNMSLQDAEWYWG---DISREEVNEKLR DTA-DGTFLVRDASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFN--- -SVVELINH-YRNESLAQY----------NPKLDVKL---LYPVSKY-QQ---------- --DQ----V-VKE--DNIEAVG-KKLHEYNTQFQEKSREYDRLY--EDYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--QSQERYSKEYIE--- KFKRE---------------GNEKE------IQ-RIMHNYEKLKSRISEIVDSRR----R LE------EDLKKQAAEYREIDKRMNSIKP-----DL--IQLRKTRDQYL------MWLT Q-KGVRQKKLNEWLG---NENTED--------Q-YSLVE--D---DEDLP-HHDEKTWNV G----------------------------------------------SSNRNKAENLLRG KRDGTFLVRES-SKQGC------------------------------------------- -----------YACSVVVDGE-VKH-CV-INKTATGYGFAEPYNLYS---SLKELVLHYQ HTSLVQHNDSL-----------------------NVTLAYPVY----------------- -----------AQQRR-------------------------------------------- -- >B_taurus_ENSBTAP00000014594 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDL ------------------------------------------------------------ -----HLGDILTVNKGSLVALG-FSDGQEAKPEEIGWLNGYNETTGERGDF-GTYVEYM- REKISPPTPKPR----PPRP--LPVAPGPSKT--EADSE-QQ------------------ ------------------------ASTLPDLAEQFAPPDVAPPLLIKLVEAIEKKG-LEC STLYRTQSSSNPAELRQLLD-----CDTASLDLEMFDVHV-LADAFKRYLLDLPNPVIPV A---VSSELISLAP--E-VQSSEEY--IQL--------------------------LKKL IRSPSIPHQYWLTLQYLLKHFFKLSQ--TSSKNLLNARVLSELFSPLLFRF------PAA -------SSE-------------------------------------------------- ---------NTEHLIKIIEILISTEWNERQ-PAP----ALPPKPPK----PTT------- ------------------------------------------------------------ --------------V--------ANNGMN---NNMSLQDAEWYWG---DISREEVNEKLR DTA-DGTFLVRDASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFN--- -SVVELINH-YRNESLAQY----------NPKLDVKL---LYPVSKY-QQ---------- --DQ----V-VKE--DNIEAVG-KKLHEYNTQFQEKSREYDRLY--EDYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--QTQERYSKEYIE--- KFKRE---------------GNETE------IQ-RIMHNYEKLKSRISEIVDSRR----R LE------EDLKKQAAEYREIDKRMNSIKP-----DL--IQLRKTRDQYL------MWLT Q-KGVRQKKLNEWLG---NENTED--------Q-YSLVE--D---DEDLP-HHDEKTWNV G----------------------------------------------SSNRNKAENLLRG KRDGTFLVRES-SKQGC------------------------------------------- -----------YACSVVVDGE-VKH-CV-INKTATGYGFAEPYNLYS---SLKELVLHYQ HTSLVQHNDSL-----------------------NVTLAYPVY----------------- -----------AQQRR-------------------------------------------- -- >M_musculus_ENSMUSP00000056774 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDL ------------------------------------------------------------ -----HLGDILTVNKGSLVALG-FSDGQEARPEDIGWLNGYNETTGERGDFPGTYVEYIG RKRISPPTPKPR----PPRP--LPVAPGSSKT--EADTE-QQ------------------ ------------------------ALPLPDLAEQFAPPDVAPPLLIKLLEAIEKKG-LEC STLYRTQSSSNPAELRQLLD-----CDAASVDLEMIDVHV-LADAFKRYLADLPNPVIPV A---VYNEMMSLAQ--E-LQSPEDC--IQL--------------------------LKKL IRLPNIPHQCWLTLQYLLKHFFKLSQ--ASSKNLLNARVLSEIFSPVLFRF------PAA -------SSD-------------------------------------------------- ---------NTEHLIKAIEILISTEWNERQ-PAP----ALPPKPPK----PTT------- ------------------------------------------------------------ --------------V--------ANNSMN---NNMSLQDAEWYWG---DISREEVNEKLR DTA-DGTFLVRDASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFN--- -SVVELINH-YRNESLAQY----------NPKLDVKL---LYPVSKY-QQ---------- --DQ----V-VKE--DNIEAVG-KKLHEYNTQFQEKSREYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--QTQERYSKEYIE--- KFKRE---------------GNEKE------IQ-RIMHNHDKLKSRISEIIDSRR----R LE------EDLKKQAAEYREIDKRMNSIKP-----DL--IQLRKTRDQYL------MWLT Q-KGVRQKKLNEWLG---NENTED--------Q-YSLVE--D---DEDLP-HHDEKTWNV G----------------------------------------------SSNRNKAENLLRG KRDGTFLVRES-SKQGC------------------------------------------- -----------YACSVVVDGE-VKH-CV-INKTATGYGFAEPYNLYS---SLKELVLHYQ HTSLVQHNDSL-----------------------NVTLAYPVY----------------- -----------AQQRR-------------------------------------------- -- >P_pygmaeus_ENSPPYP00000017341 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDL ------------------------------------------------------------ -----HLGDILTVNKGSLVALG-FSDGQEARPEEIGWLNGYNETTGERGDFPGTYVEYIG RKKISPPTPKPR----PPRP--LPVAPGSSKT--EADVE-QQ------------------ ------------------------ALTLPDLAEQFAPPDIAPPLLIKLVEAIEKKG-LEC STLYRTQSSSNLAELRQLLD-----CDTASVDLEMIDVHV-LADAFKRYLLDLPNPVIPA A---VYSEMISLAQ--E-VQSSEEY--IQL--------------------------LKKL IRSPSIPHQYWLTLQYLLKHFFKLSQ--TSSKNLLNARVLSEIFSPMLFRF------SAA -------SSD-------------------------------------------------- ---------NTENLIKVIEILISTEWNERQ-PAP----ALPPKPPK----PTT------- ------------------------------------------------------------ --------------V--------ANNGMN---NNMSLQDAEWYWG---DISREEVNEKLR DTA-DGTFLVRDASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFN--- -SVVELINH-YRNESLAQY----------NPKLDVKL---LYPVSKY-QQ---------- --DQ------VKE--DNIEAVG-KKLHEYNTQFQEKSREYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--QTQERYSKEYIE--- KFKRE---------------GNEKE------IQ-RIMHNYDKLKSRISEIIDSRR----R LE------EDLKKQAAEYREIDKRMNSIKP-----DL--IQLRKTRDQYL------MWLT Q-KGVRQKKLNEWLG---NENTED--------Q-YSLVE--D---DEDLP-HHDEKTWNV G----------------------------------------------SSNRNKAENLLRG KRDGTFLVRES-SKQGC------------------------------------------- -----------YACSVVVDGE-VKH-CV-INKTATGYGFAEPYNLYS---SLKELVLHYQ HTSLVQHNDSL-----------------------NVTLAYPVY----------------- -----------AQQRR-------------------------------------------- -- >G_gallus_ENSGALP00000023822 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDL ------------------------------------------------------------ -----HLGDILTVNKGTLLALG-FNEGEEAKPEEIGWLNGFNETTGERGDFPGTYVEYIG RKKISPPTPKPR----PPRP--LPVAPSPSKA--DAESE-QQ------------------ ------------------------AFSLPDLTEQFSPPDVAPPILIKIIETIEKKG-LEC STLYVTQSSSSSAELRQILE-----CDASSLDLETFDVHT-LSDALKRYLLDLPNPIIPA T---VYSDIISVAQ--D-VQSSEEY--AQL--------------------------LKKL IRSPNIPHQYWLTLQYLLKHFLRLCQ--ASSKNLLNARSLAEIFSPLLFKF------QIA -------SSD-------------------------------------------------- ---------NAEHHIRILEILITSEWNERQ-PVP----ALPPKPPK----PNT------- ------------------------------------------------------------ --------------V--------TNNGMN---NNMSLQDAEWYWG---DISREEVNEKLR DTA-DGTFLVRDASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFN--- -SVVELINH-YRNESLAQY----------NPKLDVKL---LYPVSKY-QQ---------- --DQ----V-VKE--DSIEAVG-KKLHEYNTQFQEKSREYDRLY--EDYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--QTQERYSKEYIE--- KFKRE---------------GNEKE------IQ-RIMHNYEKLKSRISEIVDSRR----R LE------EDLKKQAAEYREIDKRMNSIKP-----DL--IQLRKTRDQYL------MWLT Q-KGVRQKKLNEWLG---NENTED--------Q-YSMVD--D---DEDLP-HHDERTWNV G----------------------------------------------NINRSQAENLLRG KRDGTFLVRES-SKQGC------------------------------------------- -----------YACSVVVDGE-VKH-CV-INKTPTGYGFAEPYNLYN---SLKELVLHYQ HTSLVQHNDSL-----------------------NVTLAYPVY----------------- -----------AQQRR-------------------------------------------- -- >A_carolinensis_ENSACAP00000016070 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDL ------------------------------------------------------------ -----RLGDILTVNKGTLVALG-FSDGEEAKPEEIGWLNGYNETTGERGDFPGTYVEYIG RKKISPPTPKPR----PVRP--LPVAPSPSRV--GTDSD-QS------------------ ------------------------GFALPDLSEQFSSPDNAPPILIKLVEAIERKG-LEC STLYRSQGSSSTNELRQITE-----CDVSTVDFDSVDIQI-LSDALKRYFLDLPNPVIPA S---VYNEMTSIAQ--E-VQNSEEY--AQV--------------------------LKRL IRSPNIPQQYWLTLQYLLKHFSRLCQ--SSNKNLLNARSLAEIFSLLLFRC------PVA -------SSD-------------------------------------------------- ---------NTEHHIKILEVLITSEWNERQ-PAP----ALPPKPPK----PNT------- ------------------------------------------------------------ --------------V--------TNNGMN---NNMSLQDAEWYWG---DISREEVNEKLR DTA-DGTFLVRDASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFN--- -SVVELINH-YRNESLAQY----------NPKLDVKL---LYPVSKY-QQ---------- --DQ----V-VKE--DSIEAVG-KKLHEYNIQFQEKNREYDRLY--EDYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--QTQERYSKEYIE--- KFKRE---------------GNEKE------IQ-RIMHNYEKLKSRISEIVDSRH----R LE------EDLKKQAAEYREIDKRMNSIKP-----DL--IQLRKTRDQYL------MWLT Q-KGVRQKKLNEWLG---NENTED--------Q-YSMVE--D---DEDLP-HHDERTWNV G----------------------------------------------NINRSQAENLLRG KRDGTFLVRES-SKPGC------------------------------------------- -----------YACSVVVDGE-VKH-CV-INKTPTGYGFAEPYNLYN---SLKELVLHYQ HTSLVQHNDSL-----------------------NVTLAYPVY----------------- -----------AQQRR-------------------------------------------- -- >T_guttata_ENSTGUP00000003114 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDL ------------------------------------------------------------ -----HLGDILTVNKGTLLALG-FSEGEEAKPEEIGWLNGFNETTGERGDFPGTYVEYIG RKKISPPTPKPR----PPRP--LPVAPSPAKA--ESESE-QQ------------------ ------------------------AFSLPDLTEQFTPPDVAPPILVKIVETIEKKG-LEY STLYGAQGSSSAVELRQIFE-----CDTSSLDLETFDVHT-LSDALKRYILDLPNPIIPA A---VYSDMISLAQ--E-VQSSEEY--AQL--------------------------LKKL IRSPNIPPQYWLTLQYLLKHFLRVCQ--ASSKNLLNARSLAEIFSPLLFKF------QIA -------SSD-------------------------------------------------- ---------NTEHHIKILEVLITSEWNERQ-PVP----ALPPKPPK----PNT------- ------------------------------------------------------------ --------------V--------TNNSMN---NNMSLQDAEWYWG---DISREEVNEKLR DTA-DGTFLVRDASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFN--- -SVVELINH-YRNESLAQY----------NPKLDVKL---LYPVSKY-QQ---------- --DQ----V-VKE--DSIEAVG-KKLHEYNTQFQEKSREYDRLY--EDYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--QTQERYSKEYIE--- KFKRE---------------GNEKE------IQ-RIMHNYEKLKSRISEIVDSRR----R LE------EDLKKQAAEYREIDKRMNSIKP-----DL--IQLRKTRDQYL------MWLT Q-KGVRQKKLNEWLG---NENAED--------Q-YSMVE--D---DEDLP-HHDERTWNV G----------------------------------------------NINRSQAENLLRG KRDGTFLVRES-SKQGC------------------------------------------- -----------YACSVVVDGE-VKH-CV-INKTPTGYGFAEPYNLYN---SLKELVLHYQ HTSLVQHNDSL-----------------------NVTLAYPVY----------------- -----------AQQRR-------------------------------------------- -- >M_domestica_ENSMODP00000024566 -----------------------------------MSAEGYQYRALYEYK-KEREEDIDL ------------------------------------------------------------ -----HVGDVLTVNKGSLVALG-FSEGEEAKPDEIGWLNGYNETTGERGDFPGTYVEYIG RKRISPPTPKPR----PPRP--LPVAPGSSKL--ETDNE-QQ------------------ ------------------------GFTLLDLTEQFSSPAVAPPILIKLVEAIEKKG-LEC PTLYRTQSSSSLAELRQLLD-----CDASSVDLDVIDVQV-LSDAFKRYLLDLPNPVIPG T---IYSEMISVAQ--E-LQNSEEN--VQM--------------------------LKKL MRTPHIPHQHGLTLQYLLKHFFKLCQ--ASSKNLLNARSLSEIFSPVLFRF------PNT -------GSD-------------------------------------------------- ---------NAEHLIKTIELLISSEWNERQ-PAP----ALPPKPPK----PTT------- ------------------------------------------------------------ --------------VT-------ANNGMN---NNMSLQDAEWYWG---DISREEVNEKLR DTA-DGTFLVRDASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFN--- -SVVELINH-YRNESLAQY----------NPKLDVKL---LYPVSKY-QQ---------- --DQ----V-VKE--DSIEAVG-KKLHEYNTQFQEKSREYDRLY--EDYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--QTQERYSKEYIE--- KFKRE---------------GNEKE------IQ-RIMHNYEKLKSRISEIVDSRR----R LE------EDLKKQAAEYREIDKRMNSIKP-----DL--IQLRKTRDQYL------MWLT Q-KGVRQKKLNEWLG---NENTED--------Q-YSMVE--D---DEDLP-HHDERTWNV G----------------------------------------------SSNRSKAENLLRG KRDGTFLVRES-SKQGC------------------------------------------- -----------FACSVVVDGE-VKH-CV-INKTPTGYGFAEPYNLYN---SLKELVLHYQ HTSLVQHNDSL-----------------------NVTLAYPVN----------------- -----------AQQRR-------------------------------------------- -- >G_gallus_ENSGALP00000005414 M----------------------------------GSTDGFQYRALYPYR-KEREEDIDL ------------------------------------------------------------ -----VPGDILVVSKGALQALG-FKDGDEQNPNQIGWILGVNERTKQKGDFPGTYVEYVG PVKISVPSHRPR----VQRP--LPATPGASG----CRLQ-EALEQ--------------- ------------------------GSPLPDLQEQFSPPEVAPPLLVKLVEAIEKKG-LDS EMLYRTSGSELRQALR---------TDWSLGDLEPFDVHS-LSEALRGYLQDLPSPVVPV S---VHGDILRILQ--E-IPQPENC--RKQ--------------------------LLLA LESPAIPLQNTLTLQFLLRHLGKVSQ--QAESNSLHPQALGEIFGPLLLRL------P-- ------------------------------------------------------------ ---GASPELSPDFSVLFLEMLLQTKELEPEQLPP----ALPPKPPK----PKP------- ------------------------------------------------------------ --------------S--------AASLAN--GNSVPLQDAEWYWG---DISREEVNEKLR DTP-DGTFLVRDASSKIQGEYTLTLR-KG---GNNKLIKIFHREGKYGF-SEPLTFG--- -SVVELITH-YRHESLAQY----------NAKLDTRL---LYPISKY-QQ---------- --DQ----V-VKE--DSVEAVG-EQLKVYHQQYQDKSWEYDLLY--EEYTRTS------- -----QELQMKR------------TAI--EAFNETIKIFEEQC--QTQEKCSKEYIE--- RFRRE---------------GNEKE------VQ-RILMNSEKLKSRITEIHDSKM----K LE------QDLKKQASENREIDKRMNSLKP-----DL--MQLRKLRDQYL------VWLT Q-KGARQKKINEWLGIK-NE-TED--------Q-YSMMD--D---EEELP-HHEERTWYV G----------------------------------------------KINRLQAEEMLCG KRDGTFLIRES-SQKGC------------------------------------------- -----------YACSVVVDGD-TKH-CV-IYKTATGYGFAEPYNLYA---SLKDLVLHYK HTSLVQHNDSL-----------------------NVTLAHPVL----------------- -----------SQPPAR------------------------------------------- -- >M_musculus_ENSMUSP00000034296 M----------------------------------AGAEGFQYRAVYPFR-RERPEDLEL ------------------------------------------------------------ -----LPGDLLVVSRVALQALG-VADGGERCPHNVGWMPGFNERTRQRGDFPGTYVEFLG PVALARPGPRPR----GPRP--LPARPLDGSS--ES------------------------ ------------------------GHILPDLAEQFSPPDPAPPILVKLVEAIEQAE-LDS ECYSKPELP----ATR---------TDWSLSDLEQWDRTA-LYDAVKGFLLALPAAVVTP E---AAAEAYRALRE---VAGP----------------------------------VGLV LEPPTLPLHQALTLRFLLQHLGRVAR--RAPSPDTAVHALASAFGPLLLRI------PPS -------GGE-------------------------------------------------- ---GDGSEPVPDFPVLLLERLVQEHVEEQDAAPP----ALPPKPSK----AKP------- ------------------------------------------------------------ --------------A--------PTALANG-GSPPSLQDAEWYWG---DISREEVNERLR DTP-DGTFLVRDASSKIQGEYTLTLR-KG---GNNKLIKVFHRDGHYGF-SEPLTFC--- -SVVELISH-YRHESLAQY----------NAKLDTRL---LYPVSKY-QQ---------- --DQ----V-VKE--DSIEAVG-AQLKVYHQQYQDKSREYDQLY--EEYTRTS------- -----QELQMKR------------TAI--EAFNETIKIFEEQG--QTQEKCSKEYLE--- RFRRE---------------GNEKE------MQ-RILLNSERLKSRIAEIHESRT----K LE------QDLRAQASDNREIDKRMNSLKP-----DL--MQLRKIRDQYL------VWLT Q-KGARQRKINEWLGIK-NE-TED--------Q-YSLME--D---EDALP-HHEERTWYV G----------------------------------------------KINRTQAEEMLSG KRDGTFLIRES-SQRGC------------------------------------------- -----------YACSVVVDGD-TKH-CV-IYRTATGFGFAEPYNLYG---SLKELVLHYQ HASLVQHNDAL-----------------------TVTLAHPVR----------------- -----------APGPGPPSAAR-------------------------------------- -- >X_tropicalis_ENSXETP00000046442 -----------------------------------MSAEGYQYRALYPYK-KEREEDIDL ------------------------------------------------------------ -----RVGDTLTVSRATLLALGCLAEGMEARPEQIGWLNGCNENTGQRGDFPGTYVEYIG RKRISPPTPKPR----PPRP--LPVAPGAVRG--EAE---AQ------------------ ------------------------AFTLPDLTEQFSPPDTAPPVLIKLIEAIEKKG-LES ATLYRSQSSSSLTELRQILE-----CDAASVDFEQFDISI-LSDALKRYLLDLPNPVIPA L---MYSEMLSAAR--E-SISSDEY--VQL--------------------------LRKT IRCANVPQQYWLTLQYLLKHFLQLCQ--SSSKNLLSAKSLAEIFSPLLFRI------QVS -------SSD-------------------------------------------------- ---------SSEFSTQILEVLIASEWNEKQ-AAP----ALPPKPPK----STA------- ------------------------------------------------------------ --------------V--------TNNGTN---HIMSLQDAEWYWG---DISREEVNEKLR DTT-DGTFLVRDASTIMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFN--- -SVVELITH-YRNESLAQY----------NPKLDVKL---LYPVSKF-QQ---------- --DQ----L-VKE--DSIEAVG-KKLREYNVQFEEKNQEYDRLY--EDYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--QTQEKYSKEYIE--- KFRRE---------------GNEKE------IQ-RILHNHEKLKSRISEIVDSKR----R LE------EDLKKQTAEYREIDKRMNSIKP-----DL--IQLRKTRDQYL------MWLT Q-KGVRQKKLNEWLG---SENTED--------Q-YSVVE------DEDLP-HQDERTWNV G----------------------------------------------NINRNQAENLLRG KRDGTFLVRES-SKAGC------------------------------------------- -----------YACSVVADGE-VKH-CV-INKTLTGYGFAEPYNLYS---SLKELVLHYQ HTSLVQHNDSL-----------------------NVTLANPVY----------------- -----------AQQRR-------------------------------------------- -- >M_mulatta_ENSMMUP00000004228 M----------------------------------AGPEGFQYRALYPFR-RERPEDLEL ------------------------------------------------------------ -----LPGDVLVVSRAALQALG-VAEGGERCPQNVGWMPGLNERTRQRGDFPGTYVEFLG PVALARPGPRPR----GPRP--LPARPRDGAP--EP------------------------ ------------------------GLTLPDLPEQFSPPDVAPPLLVKLVEAIERTG-LDS ESHYRPELP----TPR---------TDWTLSDVDQWDVTA-LADGIKSFLLALPAPLVTP E---ASAEARRALRE---AAGP----------------------------------VGPA LEPPTLPLHRALTLRFLLQHLGRVAR--RAPALGPAVRALGATFGPLLLRA-PPPSSPPP -------GGA-------------------------------------------------- ---PDGSEPSPDFPALLVEKLLQEHLEEQEVAPP----ALPPKPPK----AKL------- ------------------------------------------------------------ --------------A--------PAGLANG-GSPPSLQDAEWYWG---DISREEVNEKLR DTP-DGTFLVRDASSKIQGEYTLTLR-KG---GNNKLIKVFHRDGHYGF-SEPLTFC--- -SVVDLINH-YRHESLAQY----------NAKLDTRL---LYPVSKY-QQ---------- --DQ----I-VKE--DSVEAVG-AQLKVYHQQYQDKSREYDQLY--EEYTRTS------- -----QELQMKR------------TAI--EAFNETIKIFEEQG--QTQEKCSKEYLE--- RFRRE---------------GNEKE------MQ-RILLNSERLKSRIAEIHESRT----K LE------QQLRAQASDNREIDKRMNSLKP-----DL--MQLRKIRDQYL------VWLT Q-KGARQKKINEWLGIK-NE-TED--------Q-YALME--D---EDDLP-HHEERTWYV G----------------------------------------------KINRTQAEEMLSG KRDGTFLIRES-SQRGC------------------------------------------- -----------YACSVVVDGD-TKH-CV-IYRTATGFGFAEPYNLYG---SLKELVLHYQ HASLVQHNDAL-----------------------TVTLAHPVR----------------- -----------APGPGPPPAAR-------------------------------------- -- >H_sapiens_ENSP00000222254 M----------------------------------AGPEGFQYRALYPFR-RERPEDLEL ------------------------------------------------------------ -----LPGDVLVVSRAALQALG-VAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLG PVALARPGPRPR----GPRP--LPARPRDGAP--EP------------------------ ------------------------GLTLPDLPEQFSPPDVAPPLLVKLVEAIERTG-LDS ESHYRPELP----APR---------TDWSLSDVDQWDTAA-LADGIKSFLLALPAPLVTP E---ASAEARRALRE---AAGP----------------------------------VGPA LEPPTLPLHRALTLRFLLQHLGRVAS--RAPALGPAVRALGATFGPLLLRAPPPPSSPPP -------GGA-------------------------------------------------- ---PDGSEPSPDFPALLVEKLLQEHLEEQEVAPP----ALPPKPPK----AKP------- ------------------------------------------------------------ --------------A--------STVLANG-GSPPSLQDAEWYWG---DISREEVNEKLR DTP-DGTFLVRDASSKIQGEYTLTLR-KG---GNNKLIKVFHRDGHYGF-SEPLTFC--- -SVVDLINH-YRHESLAQY----------NAKLDTRL---LYPVSKY-QQ---------- --DQ----I-VKE--DSVEAVG-AQLKVYHQQYQDKSREYDQLY--EEYTRTS------- -----QELQMKR------------TAI--EAFNETIKIFEEQG--QTQEKCSKEYLE--- RFRRE---------------GNEKE------MQ-RILLNSERLKSRIAEIHESRT----K LE------QQLRAQASDNREIDKRMNSLKP-----DL--MQLRKIRDQYL------VWLT Q-KGARQKKINEWLGIK-NE-TED--------Q-YALME--D---EDDLP-HHEERTWYV G----------------------------------------------KINRTQAEEMLSG KRDGTFLIRES-SQRGC------------------------------------------- -----------YACSVVVDGD-TKH-CV-IYRTATGFGFAEPYNLYG---SLKELVLHYQ HASLVQHNDAL-----------------------TVTLAHPVR----------------- -----------APGPGPPPAAR-------------------------------------- -- >P_troglodytes_ENSPTRP00000018245 M----------------------------------AGPEGFQYRALYPFR-RERPEDLEL ------------------------------------------------------------ -----LPGDVLVVSRAALQALG-VAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLG PVALARPGPRPR----GPRP--LPARPRDGAP--EP------------------------ ------------------------GLTLPDLPEQFSPPDVAPPLLVKLVEAIERTG-LDS ESHYRPELP----APR---------TDWSLSDVDQWDTAA-LADGIKSFLLALPAPLVTP E---ASAEARRALRE---AAGP----------------------------------VGPA LEPPTLPLHRALTLRFLLQHLGRVAR--RAPALGPAVRALGATFGPLLLRAPPPPSSPPP -------GGA-------------------------------------------------- ---PDGSEPSPDFPALLVEKLLQEHLEEQEVAPP----ALPPKPPK----AKP------- ------------------------------------------------------------ --------------A--------PTVLANG-GSPPSLQDAEWYWG---DISREEVNEKLR DTP-DGTFLVRDASSKIQGEYTLTLR-KG---GNNKLIKVFHRDGHYGF-SEPLTFC--- -SVVDLINH-YRHESLAQY----------NAKLDTRL---LYPVSKY-QQ---------- --DQ----I-VKE--DSVEAVG-AQLKVYHQQYQDKSREYDQLY--EEYTRTS------- -----QELQMKR------------TAI--EAFNETIKIFEEQG--QTQEKCSKEYLE--- RFRRE---------------GNEKE------MQ-RILLNSERLKSRIAEIHESRT----K LE------QQLRAQASDNREIDKRMNSLKP-----DL--MQLRKIRDQYL------VWLT Q-KGARQKKINEWLGIK-NE-TED--------Q-YALME--D---EDDLP-HHEERTWYV G----------------------------------------------KINRTQAEEMLSG KRDGTFLIRES-SQRGC------------------------------------------- -----------YACSVVVDGD-TKH-CV-IYRTATGFGFAEPYNLYG---SLKELVLHYQ HASLVQHNDAL-----------------------TVTLAHPVR----------------- -----------APGPGPPPAAR-------------------------------------- -- >B_taurus_ENSBTAP00000003033 M----------------------------------AGPEGFQYRALYPFR-RERPEDLEL ------------------------------------------------------------ -----LPGDVLVVSRAALQALG-VAEGNERCPQSVGWMPGLNERTRQRGDFPGTYVEFLG PVALARPGPRPR----GPRP--LPARPRDGPP--EP------------------------ ------------------------GLTLPDLPEQFSPPDVAPPILVKLVEAIERTG-LDS ---YRPEPP----AVR---------TDWSLSDVEQWDAAA-LSDGVKGFLLALPAPLVTP E---AAAEAHRALRE---AAGP----------------------------------VGPA LEPPTLPLHHALTLRFLLQHLGRVAG--RAPAPGPAVRALGATFGPLLLRA-PPPPSPPP -------GGA-------------------------------------------------- ---PDGTEPTPDFPALLVEKLLQEHLEEQEVAPP----ALPPKPPK----TKP------- ------------------------------------------------------------ --------------A--------PTGLANG-GSPPSLQDAEWYWG---DISREEVNEKLR DTP-DGTFLVRDASSKIQGEYTLTLR-KG---GNNKLIKVFHRDGHYGF-SEPLTFC--- -SVVDLITH-YRHESLAQY----------NAKLDTRL---LYPVSKY-QQ---------- --DQ----I-VKE--DSVEAVG-AQLKVYHQQYQDKSREYDQLY--EEYTRTS------- -----QELQMKR------------TAI--EAFNETIKIFEEQG--QTQEKCSKEYLE--- RFRRE---------------GNEKE------MQ-RILLNSERLKSRIAEIHESRT----K LE------QELRAQASDNREIDKRMNSLKP-----DL--MQLRKIRDQYL------VWLT Q-KGARQKKINEWLGIK-NE-TED--------Q-YSLME--D---EDDLP-HHEERTWYV G----------------------------------------------KINRTQAEEMLSG KRDGTFLIRES-SQRGC------------------------------------------- -----------YACSVVVDGD-TKH-CV-IYRTATGFGFAEPYNLYG---SLKELVLHYQ HASLVQHNDAL-----------------------TVTLAHPVR----------------- -----------APGPGPPPAAR-------------------------------------- -- >C_familiaris_ENSCAFP00000022072 M----------------------------------AGAEGFQYRALYPFR-RERPEDLEL ------------------------------------------------------------ -----LPGDVLVVSRAALQVLG-VAEGNERCPQSVGWMPGLNERTRQRGDFPGTYVEFLG PVALARPGPRPR----GPRP--LPARPRDGPP--EP------------------------ ------------------------GLTLPDLPEQFSPPDVAPPLLVKLVEAIERTG-LDS ESLYRPELP----APR---------TDWSLSDVEQWDAAA-LTDGVKSFLLALPAPLVTP E---AAAEARRALRE---AAGP----------------------------------VGPA LEPPTLPLHRALTLRFLLQHLGRVAR--RAPAPGPAVRALGATFGPLLLRA--PPPSPPP -------GGA-------------------------------------------------- ---PDGTEPSPDFPVLLVEKLLQEHLEEQEVTPP----ALPPKPPK----AKP------- ------------------------------------------------------------ --------------A--------PAGLANG-GSPPSLQDAEWYWG---DISREEVNEKLR DTP-DGTFLVRDASSKIQGEYTLTLR-KG---GNNKLIKVFHRDGHYGF-SEPLTFC--- -SVVDLITH-YRHESLAQY----------NAKLDTRL---LYPVSKY-QQ---------- --DQ----I-VKE--DSVEAVG-AQLKVYHQQYQDKSREYDQLY--EEYTRTS------- -----QELQMKR------------TAI--EAFNETIKIFEEQG--QTQEKCSKEYLE--- RFRRE---------------GNEKE------MQ-RILLNSERLKSRIAEIHESRT----K LE------QELRAQASDNREIDKRMNSLKP-----DL--MQLRKIRDQYL------VWLT Q-KGARQKKINEWLGIK-NE-TED--------Q-YALME--D---EDDLP-HHEERTWYV G----------------------------------------------KINRTQAEEMLSG KRDGTFLIRES-SQRGC------------------------------------------- -----------YACSVVVDGD-TKH-CV-IYRTATGFGFAEPYNLYG---SLKELVLHYQ HASLVQHNDAL-----------------------TVTLAHPVR----------------- -----------APGPGPPPATR-------------------------------------- -- >O_anatinus_ENSOANP00000002082 M----------------------------------ASTEGFQYRALYQYH-KEREEDIDL ------------------------------------------------------------ -----LPGDILVVSKGALQALG-FRDGDEQNPYQIGWIPGVNEHTNQKGGFPGTYVEYVG PVKIALPSHRPW----GQRP--LPATPGAGT----CHPQ-ESLEPA-------------- ------------------------GTLLPDVSEQFAPPEVAPPILLKLVEAIERKG-LDG EMLYRASAS----GLR---------ADWTLGDIEQWDVLT-LSETLKSYLQALPGPLVPP S---AHGDLLHALQE---APQPETC--RKQ--------------------------LLAL LEPPGVPLQNSLALHFLLRHLGKVAQ--QADRNGLSPRVLGEIFGPLLLRL------PIS -------GSPPAPPPPPQPR---------------------------------------- ---GSKAESTTDFSVLLLETLLQDQDEEQEPAPP----ALPPKPSK----PKA------- ------------------------------------------------------------ --------------S--------ANNMPT--GNGPTLQESEWYWG---DISREEVNEKLR DTP-DGTFLVRDASSKIQGEYTLTLR-KG---GNNKLIKIFHRDGQYGF-SEPLTFG--- -SVVDLITY-YRHESLAQY----------NAKLDTRL---LYPVSKH-QQ---------- --DQ----V-VKE--DSVEAVG-EQLKVYHQQYQDKSREYDLLY--EEYTRTS------- -----QELQMKR------------TAI--EAFNETIKIFEEQG--QTQEKCSKEYLE--- QFRRE---------------GNEKE------IQ-RILINSEKLKSRIAEIHNSKI----K LE------HDLRVQSADNREIDKRMNSLKP-----DL--MQLRKIRDQYL------VWLT Q-KGTRQKKINEWLGIK-NE-NED--------Q-YSMME--D---EEDLP-HHEEQTWYV G----------------------------------------------KINRGQAEEMLCG KRDGTFLIRES-SQRGC------------------------------------------- -----------YACSVVVDGD-IKH-CV-IYKTVTGYGFAEPYNLYA---SLKDLVLHYK HTSLVQHNDSL-----------------------NVTLAHPVL----------------- -----------SPPPAHPPALR-------------------------------------- -- >T_rubripes_ENSTRUP00000026404 K----------------------------------MAVEGFQYVALHSFT-KDQEEDLDL ------------------------------------------------------------ -----QPGDLLTVSKASLLSMDNYSEGCEEQPEHLGWLLGYNERTKQRGDFPGTYVKFVG SMKMALPSIQPR----SQRP--LPAAPRPDS------SQ------P-------------- ------------------------TVSMPDLSEQFTPPETAPLALVSLIQAIEKRG---- -----TSLSPEGKL-VS--------SGCSESDLGQKDVGF-LSECVLRYLKDIPSPLIPA C---IYPQLQTAVTLKQQALNQAAG----M--------------------------SKCA FNATTVPLHHRLTLQYLLTHLAKVTQ--AQASNSLDAQTLGQIFGPLLIRT------SAS -------THWCRKIY-SSNI---------------------------------------- ---PNETSLDEDFAGLVVEKLLKERTTERDITPP----VLPAKPAK----SKV------- ------------------------------------------------------------ --------------A--------PSAMTD---TSSLLTDAEWYWG---EISREEVNEKLR DTP-DGTFLVRDASSKLEGEYTLTLR-KG---GNNKLIKIYHREARYGF-SEPLTFL--- -TVVELINH-YRHESLAQY----------NAKLDTKL---LYPVSKY-QQ---T------ --AQ----L-VKE--NSIEEVG-EQLKVYHEQYQEKSREYDCLY--EEYTRTS------- -----QELQMKR------------TAI--EAFNETIKIFEEQC--ETQERYSRESLE--- RFQRE---------------GNEKE------IQ-KIQSNSERLKSRVKEIHDSKR----K LE------QDLRQQVSDNREIDKKMNSLKP-----DL--MQLRKIREQYL------IWLT Q-KGTRQKKINEWLGIK-NE-ADD--------S-YSL-E--E---DEGSP-HHDESTWYV G----------------------------------------------DIKRSHAEELLRG KCDGTFLIRESQTQKGS------------------------------------------- -----------YACSVVVDGD-AKH-CV-VYKTVTGYGFAEPYNLYS---SLKDLVLHYK NVSLVQHNDHL-----------------------NVTLAHPVL----------------- -----------ARSQNQNQ-HPR------------------------------------- -- >T_nigroviridis_ENSTNIP00000014006 -----------------------------------MAVEGFQYVALHAFT-KDQEEDLDL ------------------------------------------------------------ -----QPGDLLTVSKASLVSLDSYSEGCEEQPEHLGWLLGYNERTKQRGDFPGTYVRYVG PMKMAPPSSQPR----SQRP--LPAAPRPDP------SQ-GDVERQ-------------- ------------------------AVSMPDLSEQFTPPETAPPTLVSLIQAVEKRG-LES EALYRSTDSPVPDVPVY--------SLCSESDLGQKDVAY-LSECVLRYLKALPSPLIPA C---IYPQLQTAVGLTQQALNQAAGQDREV--------------------------SLVI EKATTVPLHHRLTLQFLLTHLAKVTQ--AQASNGLDAQTLGQIFGPLLVWS------STS -------AHW-------------------------------------------------- ------TPLDEGFAETVVEKLLTERTTEQDVTPP----VLPAKPAK----SKV------- ------------------------------------------------------------ --------------A--------PSAMTD---TSSLLNDAEWYWG---EISREEVNEKLR DTP-DGTFLVRDASSKLEGEYTLTLR-KG---GNNKLIKIYHREGRYGF-SEPLTFL--- -SVVELINH-YRHESLAQY----------NAKLDTKL---LYPVSKY-QQ---------- --SQ----L-VKE--NSIEEVG-EQLKVYHDQYQEKSREYDCLY--EEYTRTS------- -----QELQMKR------------TAI--EAFNETIKIFEEQC--ETQERYSRESLE--- RFQRE---------------GNEKE------IQ-KIQSNSERLKSRVKEIHDSKR----K LE------QDLRQQASDNREIDKKMNSLKP-----DL--M-LRKIREQYL------IWLI Q-KGTRQKKINEWLGIK-NE-ADD--------S-YSL-E--E---DESSP-HHDESTWYV G----------------------------------------------DIKRSQAEEMLRG TCDGTFLIRESQTQKGS------------------------------------------- -----------YACSVVVDGD-TKH-CV-VYKTVTGYGFAEPYNLYS---SLKDLVLHYK NVSLVQHNDHL-----------------------NVTLAHPVL----------------- -----------ARSQN-------------------------------------------- -- >G_gorilla_ENSGGOP00000015802 M----------------------------------AGPEGFQYRALYPFR-RERPEDLEL ------------------------------------------------------------ -----LPGDVLVVSRAALQALG-VAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLG PVALARPGPRPR----GPRP--LPARPRDGAP--EP------------------------ ------------------------GLTLPDLPEQFSPPDVAPPLLVKLVEAIERTG-LDX XXXXXXXXX----XXX---------XXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXX X---XXXXXXXXXXX---XXXX----------------------------------XXXX XXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX -------XXX-------------------------------------------------- ---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----XLPPKPPK----AKP------- ------------------------------------------------------------ --------------A--------PTVLANG-GSPPSLQDAEWYWG---DISREEVNEKLR DTP-DGTFLVRDASSKIQGEYTLTLR-KG---GNNKLIKVFHRDGHYGF-SEPLTFC--- -SVVDLINH-YRHESLAQY----------NAKLDTRL---LYPVSKY-QQ---------- --DQ----I-VKE--DSVEAVG-AQLKVYHQQYQDKSREYDQLY--EEYTRTS------- -----QELQMKR------------TAI--EAFNETIKIFEEQG--QTQEKCSKEYLE--- RFRRE---------------GNEKE------MQ-RILLNSERLKSRIAEIHESRT----K LE------QQLRAQASDNREIDKRMNSLKP-----DL--MQLRKIRDQYL------VXXX X-XGARQKKINEWLGIK-NE-TED--------Q-YALME--D---EDDLP-HHEERTWYV G----------------------------------------------KINRTQAEEMLSG KRDGTFLIRES-SQRGC------------------------------------------- -----------YACSVVVDGD-TKH-CV-IYRTATGFGFAEPYNLYG---SLKELVLHYQ HASLVQHNDAL-----------------------TVTLAHPVR----------------- -----------APGPGPPPAAR-------------------------------------- -- >G_aculeatus_ENSGACP00000020473 -----------------------------------MATEGFQYVALHAFT-KDQEEDLDL ------------------------------------------------------------ -----QPGDLLTVSEASLLSMENYQEGCEQQPELLGWLLGYNERTKQRGDFPGTYVEYVG PVKMALPASQPR----SQRP--LPVAPRPES------LQ--------------------- ------------------------AVSALELSEQFTPPETAPPALAGLIQALEKRV---- -----TAANHHSRK-KC--------GQTSSSKAGQNFFLWNFSSGIL-----LPFKLLSH CSSRSYSSRQSSLSSFGTDGAVAGSHGREV--------------------------SLVL ESSPSVPLHHRLTLQYLLTHLAKVTH--LQASNGLDTHTLGKIFGPLLIRT------GPS -------TPW-------------------------------------------------- ------LSGDDELPALVVERLLIERTTEQDLAPP----VLPAKPVK----SQL------- ------------------------------------------------------------ --------------A--------PLAMAD---TSSLNDAAEWYWG---EISREEVNEKLR DTP-DGTFLVRDASSRLEGEYTLTLR-KG---GNNKLIKIYYRDGRYGF-SEPLTFL--- -SVVELIDH-YRHESLAQY----------NGKLDTKL---LFPVSKY-QQLVAC------ --TQ----L-VKE--NSIEEVG-EQLKVYHEQYQEKSREYDSLY--EEYTRTS------- -----QELQMKR------------TAI--EAFNETIKIFEEQC--ETQERYSRESLE--- KFQRE---------------GNEKE------IQ-KIQSNSERLKSRVKEIHDSKR----K LE------QDLRQQVSDNREIDKKMNSLKP-----DL--MQLRKIRDQYF------IWLT Q-KGTGQKKINEWLGIK-ND-ADD--------S-FSL-E--E---DEGSP-HHDESTWYV G----------------------------------------------DIKRTQAEEMLRG KCDGTFLIRESQSQKGS------------------------------------------- -----------YACSVVVEGD-AKH-CV-IYKTATGYGFAEPYNLYS---SLKDLVLHYK NVSLVQHNDHL-----------------------NVNLAYPVM----------------- -----------APSQN-------------------------------------------- -- >M_domestica_ENSMODP00000002600 -----------------------------------------MYTPPWGMEREDGGE---- ------------------------------------------------------------ -------------------GEGEGGEGGES------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------EDWRDVTMPYS------------------------ ------------------------------------------------------------ --------------TELIFYI--------------------------------------- ------------------------------------------------------------ -----------------------------EMDPP----ALPPKPPK----SLT------- ------------------------------------------------------------ --------------QA-------GANGAKD-SSGFSLPDAEWYWG---DISREEVNDKLR DMP-DGTFLVRDASTKVQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFS--- -SVVELINH-YRHESLAQY----------NPKLDTGLGGSSASPSCA-RQ---------- --DQ----L-VKE--DNIDAVG-TKLQEYHSQYQDKSREYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--QTQERQSKDYIE--- RFRRE---------------GNEKE------IE-RLQG---------WRLHEAPP----G TI------ETLPALGIDQWEGEGGASAQQPTGHLGSL--LQGPKV-GRCG------VGLA L-LGPSRVQHTPGLL---APDTAP--------T-YFMKE--E---EENRP-HKDEKTWFV G----------------------------------------------DLNRLQAEDLLHG KPDGAFLIRES-SKKGC------------------------------------------- -----------YACSVVADGD-VKH-CV-IYSTARGYGFAEPYNLYG---TLKELVLHYQ HTSLVQHNDSL-----------------------NVRLAHPVY----------------- -----------AQLPSHCR----------------------------------------- -- >D_rerio_ENSDARP00000090206 -----------------------------------MAADGFQYRSIYSYR-KDWEHDIDL ------------------------------------------------------------ -----EPGDILTVDKGSLLSLG-IKEGDEQHPECIGWILGFNERTKQRGDFPGTYVQYVG PVKLSAPYCQPR----SQRP--LPAVPRPEP-----TAS-LQGQKS-------------- ------------------------SKTDLDLTKQFMHPETAPPNLIKLIEAVERSG-LDC RTLYRTSASDNQRPSLSDINCDM--AELQDLDVGQWDIHA-LSEAVIRYLQDLPAPIIPP C---VYTDLQAAVQL-ESGTDVPSVRRREL--------------------------LQQV LDKPEVPLQNLLTLHYLLQHLDKVCQ--SAEQNGLDIYTLGQIFGPLLFRG------PVS ------------------------------------------------------------ -----GSEEDEAFPAAAVERLLLERIWEQEPTPP----ALPPKPPK----AKA------- ------------------------------------------------------------ --------------M--------ASSVTN--GSDSLLSEAEWYWG---DISREEVNEKMR DTP-DGTFLVRDASSKVHGEYTLTLR-KG---GNNKLIKIFHRGGKYGF-SEPLTFL--- -SVVELINH-YRHESLAQY----------NAKLDSHL---LFPVSKY-QQ---------- --DQ----V-VKE--DSIEAVG-EQLKVYHEQYQEKSREYDVLY--EEYTRSS------- -----QELQMKR------------TAI--EAFNETIKIFEEQC--ETQERLSRDSIE--- KFRRE---------------GNDKE------IE-RIQSNSEKLKSRVTEIHDSKR----K LE------LDLKRQATDNREIDKLMNSLKP-----DL--IQLRKLRDQYL------VWLT Q-KGTRQRKINEWLGIK-NE-SED--------F-YSLLD--D---DDDQA-HHDECSWYV G----------------------------------------------DIKRSYAEDLLRG KRDGTFLIRESQTQKGS------------------------------------------- -----------FACSVVVEGE-IKH-CV-VYKTATGFGFAEPYNLYG---SLKDLVLHYK HTSLVQHNDSL-----------------------NVTLAYPVL----------------- -----------AQQPR-------------------------------------------- -- >M_domestica_ENSMODP00000002126 M----------------------------------ASAEGFQYRALYQYH-KEREEDLDL ------------------------------------------------------------ -----LPGDILVVSKGTLEALG-YQDGDEQSPQHIGWILGVNERTKQKGDFPGTYVEYLG PVKIALPSHRPR----GHRP--LPATPG--------RPR-DSPEPA-------------- ------------------------GALLPDLPEQFVPPEVAPPILQKLVEAIERKG-LDS DALYRPSSEPR--PPK---------IDWTLSDVDQWDVTA-LSEALKGYLQALPRPLVPP G---AHGDILHALQ--G-ESPPS-----QQ--------------------------LQVA LEPPVVPLHNALTLRFLLQHLGRVAQRARAQGSGLGPQALGEIFGPLLLRL------PAT -------GSGGPPPP--------------------------------------------- -----RTEQSPDFSALFLEMLLQDQEEEQEPPPP----ALPPKPPK----PKV------- ------------------------------------------------------------ --------------Q--------AGSLSN--GSSAPLQEAEWYWG---DISREEVNEKLR DTP-DGTFLVRDASSKIQGEYTLTLR-KG---GNNKLIKVFHRDGQYGF-SEPLTFS--- -SVVELITH-YRHESLAQY----------NAKLDTRL---LYPVSKH-QQ---------- --DQ----V-VKE--DSVEAVG--QLKVYHQQYQDQSREYDLLY--EEYTRTS------- -----QELQMKR------------TAI--EAFNETIKIFEEQG--QTQEKCSKDYLE--- RFRRE---------------GNEKE------IQ-RILMNSEKLKSRIAEIHDSKM----K LE------QDLRAQAADNREIDKRMNSLKP-----DL--MQLRKIRDQYL------VMDE RLRGGTERRPGRALRLP-PSLTHS--------Q-YSMVD--E---EEDLP-HHEERTWYV G----------------------------------------------KINRGRAEEMLSG KRDGTFLIRES-SQRGC------------------------------------------- -----------YACSVVVDGD-TKH-CV-IYKTVTGYGFAEPYNLYA---SLKDLVLHYK HTSLVQHNDSL-----------------------NVTLAHPVL----------------- -----------SPPPAR------------------------------------------- -- >P_pygmaeus_ENSPPYP00000010903 M----------------------------------AGPEGFQYRALYPFR-RERPEDLEL ------------------------------------------------------------ -----LPGDVLVVSRAALQALG-VAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLG PVALARPGPRPR----GPRP--LPARPRDGAP--EP------------------------ ------------------------GLTLPDLPEQFSPPDVAPPLLVKLVEAIERTG-LDS ESHYRPELP----APR---------TDWSLSDVDQWDAAA-LADGIKSFLLALPAPLVTP E---ASAEARRALRE---AA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------SEPSPDFPALLVEKLLQEHLEEQEVAPP----ALPPKPPK----AKP------- ------------------------------------------------------------ --------------A--------PTGLANG-GSPPSLQDAEWYWG---DISREEVNEKLR DTP-DGTFLVRDASSKIQGEYTLTLR-KG---GNNKLIKVFHRDGHYGF-SEPLTFC--- -SVVDLINH-YRHESLAQY----------NAKLDTRL---LYPVSKY-QQ---------- --DQ----I-VKE--DSVEAVG-AQLKVYHQQYQDKSREYDQLY--EEYTRTS------- -----QELQMKR------------TAI--EAFNETIKIFEEQG--QTQEKCSKEYLE--- RFRRE---------------GNEKE------MQ-RILLNSERLKSRIAEIHESRT----K LE------QQLRAQASDNREIDKRMNSLKP-----DL--MQLRKIRDQYL------VWLT Q-KGARQKKINEWLGIK-NE-TED--------Q-YALME--D---EDDLP-HHEERTWYV G----------------------------------------------KINRTQAEEMLSG KRDGTFLIRES-SQRGC------------------------------------------- -----------YACSV--------------------FGFAEPYNLYG---SLKELVLHYQ HASLVQHNDSL-----------------------TVTQAHPVR----------------- -----------APGPGPPPAAR-------------------------------------- -- >T_guttata_ENSTGUP00000000409 M----------------------------------GSTDGFQYRALYPYR-KEREEDIDL ------------------------------------------------------------ -----LPGDILVVSKGALQALG-FKDGDEQTPNQIGWILGVNERTKQKGDFPGTYVEYVG PVKIAVPSHRPR----GPSP--ELQEPCPGWS--ST------------------------ ------------------------RSPLPDLQEQFSPPEIAPPLLVKLVEAIEKKG-LDS EIYACPEFL----AEV---------VDWTLGDLEPLDVHS-LGEALRGYLQDLPSPVVPV S---VHGDILRILQV---VPAV----------------------------------PALS LVRLAVPLQNTLTLQFLLRHLGKVSH--QAESNSLHPRALGELFGPLLLRL------PGA -------R---------------------------------------------------- ---GRGSSDIPDFSVLFLETLLQTKELEPEQLPP----ALPPKPPK----PKP------- ------------------------------------------------------------ --------------S--------AASLAN--GNNAPLQDAEWYWG---DISREEVNEKLR DTP-DGTFLVRDASSKIQGEYTLTLR-KG---GNNKLIKIFHREGKYGF-SEPLTFG--- -SVVELITH-YRHESLAQY----------NAKLDTRL---LYPISKY-QQ---------- --DQ----V-VKE--DSVEAVG-EQLKVYHQQYQDKSWEYDLLY--EEYTRTS------- -----QVWTPRR------------TGF--EEGDILPAARRELLWGNPREKCSKGVHE--- RFRRE---------------GKE-E------VQ-RILMNSEKLKSRITEIHDSKM----K LE------QDLKKQASENREIDKRMNSLKP-----DL--MQLRKLRDQYL------VWLT Q-KGARQKKINEWLGIK-NE-TED--------Q-YSMMD--D---EEELP-HHEERTWYV G----------------------------------------------KINRVQAEEMLCG KRDGTFLIRES-SQKGC------------------------------------------- -----------YACSVVVDGD-TKH-CV-IYKTATGYGFAEPYNLYA---SLKDLVLHYK HTSLVQHNDSL-----------------------NVTLAHPV------------------ ------------------------------------------------------------ -- >O_latipes_ENSORLP00000003326 -----------------------------------MSAEAYQYRALYDYK-KEREEDIDL ------------------------------------------------------------ -----HEGDVLLVSKGALVALG-YTDGLEQQPNKIGWLPGFNETTQEKGDFPGTYVEYIG RKWISPPTPKPR----PVRP--LPVAPSPVKTDEESDSE-QG------------------ ------------------------GSCLPDLTEQFSLPDTAPPMLTRLLEAIEKKG-LEN PTLYRTFTAGAGLEVRQYFE-----SDPPSADLDQLDLPV-LCDGLRRYLLDLPQPVVHP A---LQVQMVHTAK--AEVANPEEC--AQL--------------------------LRRV ASTPSLPHQYWLALHCLLRHFARVCQ--SGSKNLLSPRTLGEIFSPVFFRQ------QSV ------------------------------------------------------------ -----GCEPSLDAYIKIIEVLVTTEWSESR-AAPEFLFSPPPTPP-----PST------- ------------------------------------------------------------ --------------A--------RSACAA---SSGRSHDTRWEGGAEQESSSAEEEERKR EEG-DASGFRLRSCERCR---TXAFR-KG---GNNKLIKIFHRDGKYGF-SDPLTFS--- -SVVELINH-YRNESLAQY----------NPKLDVKL---LYPVSKQ-QQ---------- --DQ----V-VKE--DNIEAVG-RKLCEYHQQYQEKNKEYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--QTQERYSKDYIE--- RFRKE---------------GNEKE------IQSRIMGNYEKLKSRISEIVDSKR----R LE------EDLRKQAADYREIDKRMNSIKP-----DL--IQLRKTRDQYL------TWLT Q-KGVRQKKLNEWLGIK-NENTED--------Q-YSMVE--D---DEDLP-HHDERTWKL E----------------------------------------------KIDRLEAEGLLQG KRDGTFLVRES-SKPGC------------------------------------------- -----------YACSVMVDGE-VKH-CV-INKTPSGYGFAEPYNLYS---SLKELVLHYQ HTSLVQHNDSL-----------------------NVTLAYPVF----------------- -----------THQRR-------------------------------------------- -- >R_norvegicus_ENSRNOP00000025687 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDL ------------------------------------------------------------ -----HLGDILTVNKGSLVALG-FSDGQEARPEDIGWLNGYNETTGERGDFPGTYVEYIG RKRISPPTPKPR----PPRP--LPVAPGSSKT--EADTE-QP------------------ ------------------------VLTLPDLAEQFAPPDVAPPLLIKLLEAIEKKG-LEC STLYRTQSSSNPAELRQLLD-----CDAASVDLDVFDVHV-LADAFKRYLADLPNPVIPV A---VYNEMMSLAQ--E-VPSSEDY--IQL--------------------------LKKL IRSPNIPHQYWLTLQYLLKHFFKLSQ--ASSKNLLNARALSEIFSHVLFRF------PAA -------SSD-------------------------------------------------- ---------NTEHLIKAVELLISTEWSERQ-PAP----G---KGLQ----HLT------- ------------------------------------------------------------ --------------F--------TSGSAF---LDLEM----WFLS---SLESTQVSGV-- TAV-DSNMLIYGSWKNNGGGWRYL---KG---GNNKLIKIFHRDGKYGF-SDPLTFN--- -SVVELINH-YRNESLAQY----------NPKLDVKL---LYPVSKY-QQ---------- --DQ----V-VKE--DNIEAVG-KKLHEYNTQFQEKSREYDRLY--EEYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--QTQERYSKEYIE--- KFKRE---------------GNEKE------IQ-RIMHNHDKLKSRISEIIDSRR----R LE------EDLKKQAAEYREIDKRMNSIKP-----DL--IQLRKTRDQYL------MWLT Q-KGVRQKKLNEWLG---NENTED--------Q-YSLVE--D---DEDLP-HHDEKTWNV G----------------------------------------------SSNRNKAENLLRG KRDGTFLVRES-SKQGC------------------------------------------- -----------YACSVVVDGE-VKH-CV-INKTATGYGFAEPYNLYS---SLKELVLHYQ HTSLVQHNDSL-----------------------NVTLAYPVY----------------- -----------AQQRR-------------------------------------------- -- >T_rubripes_ENSTRUP00000030226 ----------------------------------------------------D------- ------------------------------------------------------------ ----------YYFDSGMV--------------------------------YPSEGLFYI- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EMDQAPP----ALPPRSNK----QVS------- ------------------------------------------------------------ --------------PT-------TNNNCHL-PPPYSLQDAEWYWG---DISRDEVNEKLR DKP-DGSFMVRDASTKLQGDFTLTLR-KD---GHNKLIKIYHRDGKYGF-SDPLTFT--- -SVVELIWY-YQHHSLVEY----------NAMLDLML---IYPVSRF-QK---------- --KC----Q-VKG--DSVDVAG-RKLKEVHSQYQEKTKEFDRLY--EAFTKTS------- -----QEIQMKR------------TAI--EAFNETMLIFEEQC--REQERYGEEIDR--- NNCSE---------------ADDKD------LE-SFLINYEKLKCRLGEIYDSKI----H LE------EDLRTQVEDYRETDRKMNSLRP-----DL--IQLRNIRDQYL------NWLN H-KGVRQKRINDWLGTQ-GDSLDD--------T-YVLKG--D---EKNLP-HQDETYWFV G----------------------------------------------EMSRTQAEEMLQG KDPGTFLIRES-SKQGS------------------------------------------- -----------YACSVVVNEE-VKH-CM-IYRTPHGYGFAEPYDVHC---SLKDLVLHYR LHSLAQHNDAL-----------------------DVRLSHPVH----------------- -----------AKSPATPP-Q--------------------------------------- -- >G_aculeatus_ENSGACP00000021319 ----------------------------------------------------RQDDVTNS ------------------------------------------------------------ -----PLKSLYFRDEGMV--------------------------------YPSEGLFYI- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EMDQAPP----ALPPRSTK----PAS------- ------------------------------------------------------------ --------------ST-------TNNNCLS-PPTHSLQDAKWYWG---DITRDEVNEKLR DTP-DGSFMVRDASTKLQGDFTLTLR-KD---GHNKLIKIYHCDGKYGF-SDPLTFT--- -SVVELIWH-YQHHPLVEY----------NATLDLML---THPVSRF-QQ---------- --ES----DTVKE--DSVDVAG-RKLKEVHCHYQERSKEFDRLY--EAFTKTS------- -----QEIQMKR------------TAI--EAFNETMLIFEEQC--REQERYGEKFEM--- NNHSE---------------GADKD------LE-SFLINYEKLKCRLGEIYESKI----H LE------DDLRTQVEDYRETDRKINSLRP-----DI--IQLRNIRDLYL------NWLN H-KGVRQKRINDWLGIL-SDSLDD--------T-YVLKG--D---EKNLP-HQEEANWFV G----------------------------------------------ELSRTQAEEMLQD KAPGTFLIRES-SKQGC------------------------------------------- -----------YACSVVVNEE-VKH-CM-IYSTPQGYGFAEPYDAHC---SLKDLVLHYR LHSLAQHNDAL-----------------------DVRLSHPVH----------------- -----------AEPAAVTP-SQ-------------------------------------- -- >T_nigroviridis_ENSTNIP00000009742 ----------------------------------------------------D------- ------------------------------------------------------------ ----------YYFDTGMV--------------------------------YPPEGLFYI- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EMDQAPP----ALPPRSNK----QGS------- ------------------------------------------------------------ -----------SAMSN-------NNNNCLL-PPAYSLQDAEWYWG---DISRDEVNEKLR DKP-DGSFMVRDASTKLQGDFTLTLR-SDEGHGHNKLIKIYHREGKYGF-SDPLTFT--- -SVVELIWY-YQHHSLVEY----------NAMLDLML---TYPVSRF-QT---------- --KF----Q-VKG--DSVDVAG-RKLKEVHSQYQEKTKEFDRLY--EAFTKTS------- -----QEIQMKR------------TAI--EAFNETMLIFEEQC--REQERYGEEIDR--- NNCSE---------------GADTD------LE-SFLINYEKLKCRLGEIYDSKI----H LE------EDLRTQVEDYRETDRKMNSLRP-----DL--IQLRNIRDQYL------NWLN H-KGVRQKRINDWLGAQ-NDSLDD--------T-YVLKG--D---EKNLP-HQDETYWFV G----------------------------------------------EMSRTQAEEMLQG KDPGTFLIRES-SKQGS------------------------------------------- -----------YACSVVVNQE-VKH-CM-IYRTPHGYGFAEPYDVHC---SLKDLVLHYR LHSLAQHNDAL-----------------------DVRLSHPVH----------------- -----------AKSPATPT-R--------------------------------------- -- >O_latipes_ENSORLP00000013359 -----------------------------------------TVNLIFNRK-KRQTATWTS ------------------------------------------------------------ -----YVKQEW--XXXXV--------------------------------YPSEGLFYI- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EMDQAPP----A-SSRSSK----PVM------- ------------------------------------------------------------ --------------SG-------MNNNCLS-LPVHSLLDAEWYWG---DITRDEVNEKLR DTP-DGSFLVRDASTKLQGDFTLTLR-KD---GHNKLIKIYHCDGKYGF-SDPLTFT--- -SVVELIWY-YQHHSLVEY----------NATLDLML---TNPVSRF-QQ---------- --VS----V-VKE--DNVDVAG-RKLKELHNQYQVKSKEFDQLY--EAFTKTS------- -----QEIQMKR------------TAI--EAFNETMMIFEEQC--REQERYGEEIER--- N--SE---------------GTDND------LE-SFLINYEKLKCRLGEIYDSKI----H LE------EDLRIQVEDYRDTDRKINSLRP-----DL--IQLRNIRDQYL------NWLN H-KGVRQKRINDWLGIH-NDSFDD--------T-YVLKG--D---EKNLP-HNDEASWFV G----------------------------------------------ELSRTQAEEMLQD KAAGTFLIRES-SKQGC------------------------------------------- -----------YACSVVVNQE-VKH-CK-IYSTPHGYGFAEPYDIHC---SLKDLVLHYR LHSLAQHNDAL-----------------------DVRLSHPVN----------------- -----------AKDATAAA-S--------------------------------------- -- >X_tropicalis_ENSXETP00000028313 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GTPLPELVDQFSPPDVAPPVLARLLEAIEKRGGTKS SKNNICLCLPH--------------IDLSSVELEATDVHS-LAEAVMVFLQELPSPVIPV Q---VHQEIIQALLEQK----------RMQ--------------------------ISLI IQPPVVPLHHVLTFQHILRHIVNMCS----ESSGLTHKMAAEIFGPLLLRP------VIT --------------GKPAYI---------------------------------------- ---QHKAEALPDFPVLLLELLLQDRGLQNDQPPP----ALPPKPTK----PKP------- ------------------------------------------------------------ --------------P--------MVTASG---GGGTLQEAEWYWG---DISREEVNDKLR DTP-DGTFLVRDASSKIRGEYTLTLR-KG---GNNRLIKIFHRDDMYGF-SEPLTFT--- -SVVALINH-YRHESLAQY----------NAKLDTRL---LYPMSKY-QQLLYI------ --NY----LPVSP--DSLQISS-VILAVY---------SYPKFFRPEKRSENS------- -----SGTPCRS------------NLC--SGLHQEIEKYEHFS--HSSKKIFCTNFSLPI RFLRK---------------XNNKE------IE-RIMMNSEKLKSRVTEIHDSKM----K LE------QDLKKQASENREIDKKMNSLKP-----DL--MQLRKLRDQYL------LWLL E-KGARQKDVSEWLDMK-NE-PED--------P-YSMM---D---DEDLP-HHEEHTWYM G----------------------------------------------KMKREQAEEMLAG KPDGTFLIRVS-RQKGC------------------------------------------- -----------YACSVVVDSD-TKH-CM-IYKAATGYGFAEPYNLYS---SLKELVLHYQ HTSLVQHNDAL-----------------------NVTLSYPVL----------------- -----------APPPRFQSPSPTRV----------------------------------- -- >T_rubripes_ENSTRUP00000017331 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------NLSDVEWYWG---SISREEVNSMMR NTP-DGTFLVRDASSKVKGEYTLTLR-KD---GSNRLIKIFNKQGRVGF-TEPLAFP--- -SVVHLIQY-YQNRSLAQY----------NAKLDTRL---LYPVSRH-QQ---------- ---Q----V-VME--INIEAVG-QQLRMLQDQYKEKSKEYDRLY--EKFNQTS------- -----QDLQSNR------------TAI--EAFGEIIRIFEEEC--ETQERYSKEYID--- MFLTL---------------DNGAE------TD-KIQSGSDELQSRVEEIHSSKK----K LE------EELRSKALAHMEMDKKINSLRP-----DL--MQLRKLRDQYL------LWLT Q-QGFRQSQINDWLGIR-NE-EES------SSP-YTLAD--D-------T-HQEERSWYV G----------------------------------------------NMKRKEAEELLKG RRDGTFLIRDSQTQRGS------------------------------------------- -----------FACSVVVNGD-VKH-CM-IYRTSTGYGFAEPYNLYS---SLRDLVLHYR HTSLIQHNQQL-----------------------NVTLAWPAL----------------- -----------SQQPRYCR----------------------------------------- -- >G_aculeatus_ENSGACP00000010853 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------LSDAEWYWG---STSREEVNEMMR NTP-DGTFLVRDASSKVKGEYTLTLR-KD---GYNRLIKIFHRGGKYGF-SEPVGFA--- -SVVNLIQF-YQNKSLAQY----------NSKLDTKL---LYPITRY-QQ---------- --QQ----I-A----VDIDAVG-EQLRIFQDQYKEKSKEYDRLF--EKFNQTS------- -----QELQSKR------------TAI--EAFSEIIRIFEEEC--ETQERYSKEYID--- MFMTL---------------DSITQ------TD-KIQNNSDELQSRVEEIHNSKK----K LE------EELRRKAVAHMEVDKKMDSLKP-----DL--VQLRKIRDQYL------LWLT Q-QGTRQSQINDWLGIK-NE-EED--------P-YTLAE--D-------P-DQEERSWYV G----------------------------------------------GMRRREAEELLRG RKDGTFLIRDSQTQRGS------------------------------------------- -----------FACSVVVDGG-VKH-CV-IHRTSTGYGFAEPFNQHP---TLRELVLHYR HTSLIQHNQQL-----------------------NVTLAWPAL----------------- -----------SQQPRLTK----------------------------------------- -- >E_caballus_ENSECAP00000007453 M----------------------------------AGAEGFQYRALYRFR-R-RPEDLEL ------------------------------------------------------------ -----LPGDVLVVSRAALQALG-VAEGSERCPQSVGWMPGFNERTRQRGDFPGTYVEFLG PVALARPGPRPR----GPRP--LPARPRDGP------------PEP-------------- ------------------------GRGLGGGSGGGVPSDPRFPLLCMLMHCPSSWG-LQT GSPEEPPFFQ---------------KEGSHPKLKRWELQA-TARGAKGHLPPLPGLRWPP G---------------QALPSKSARALCHQ--------------------------LGPA LARPQFPHLEHLETGRVLLCLQALPLR-APETSRRAAAASATSLGPDPVSP------GPL -----------------PGC---------------------------------------- ---APRRRSPLSEPQFLVCKMGPPELSFRTAAPH----QPEPRPP-----PLS------- ------------------------------------------------------------ --------------PAGPGL---PLPCAR---ASLPGARAHPRWR---GEAAERLNTKSP DDA-IGHFLRRVLSSQQQ--QFLLSR-PG---GQEPQVQVRRRERLGSF-QEPCQ-C--- -AVPSCQAS-HSPTCLSKG----------HARSGTAL---MALVC---PQ---------- --DQ----I-VKE--DSVEAVG-AQLRVYHQQYQDKSREYDQLY--EEYTRTS------- -----QELQMKR------------TAI--EAFNETIKIFEEQG--QTQEKCSKEYLE--- RFRRE---------------GNEKE------MQ-RILLNSERLKSRIAEIHESRT----K LE------QELRAQASDNREIDKRMNSLKP-----DL--MQLRKIRDQYL------VWLT Q-KGARQKKINEWLGIK-NE-TED--------Q-YALME--D---EEDLP-HHEERTWYV G----------------------------------------------KINRTQAEEMLSG KRDGTFLIRES-SQRGC------------------------------------------- -----------YACSVVVDGD-TKH-CV-IYRTATGFGFAEPYNLYG---SLRELVLHYQ HTSLLQHNDAL-----------------------AVTLAHPVR----------------- -----------APAPAP------------------------------------------- -- >T_nigroviridis_ENSTNIP00000013096 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------ASDSSS---EDDCLSDAEWYWG---SLSREEVNNMMR NTP-DGTFLVRDASSKVEGEYTLTLR-KD---GSNRLIKIFNKGGRAGF-TEPLAFT--- -SVVHLIRF-YQNRSLAQY----------NAKLDTRL---LYPVSRH-Q----------- ---Q----V-VME--IDIDAVG-QQLRMLQDQYKEKSKEYDLLY--EKFNQTS------- -----QDLQSKR------------TAI--EAFGEIIRIFEEEC--ETQERYSKEYID--- MFLAL---------------DTGAE------SD-KIQSSSDELQSRVEEIHSSKK----Q LE------EELRSKALAHMEMDKKIHSLRP-----DL--MQLRKLRDQYL------LWLA Q-QGIRQSQINHWLGIS-SQ-EED--------P-YTLAD--D-------S-HQKESSWYG G----------------------------------------------SMKRKEAEELLKG RRDGTFLIRDSQTQRGS------------------------------------------- -----------FACSVVVNGD-VKH-CV-IYRTPAGYGFAEPYNLHA---SLRDLVLHYR HTSLVQHNQQL-----------------------NVTLAWPAL----------------- -----------SQQPSLCV----------------------------------------- -- >T_nigroviridis_ENSTNIP00000006602 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R STT-TGSFLTPDGSFLVQGDYTLTPG-KG---GSNKLIRILHGDGRFGF-SEPLTFD--- -SVVELIGH-HQHQSLAQY----------NSKLDVRL---LFPVSRF-QQ---------- --DQ----L-LKE--VTLEEVG-RRLQEYHSQFQEQSRQYDRLQ--EDYARTS------- -----QEIQMKR------------TAI--EAFNETISIFEEQC--HTQERQRQD------ ---QA---------------GPEAG------PE-RVLLTYERLKERLSEIHLSRQ----R LE------EELRSQDQELRQAQQQMSGLRP-----HL--LRLRRLRDQHL------LWLN R-RGVRQRRISDWLGMR-SPEEER--------S-SCL----------SLP-HHDERSWFV G----------------------------------------------DLKRGEAEELLLG RPDGSFLVRES-SRKGC------------------------------------------- -----------YACSVVVEGV-VTA-LRGAADADGGFGFAEPFDRHA---SLKELVLHYR RASLAQHNRAL-----------------------DVRLAFPVH----------------- -----------AHTPSGRGVRPRPR----------------------------------- -- >O_anatinus_ENSOANP00000007081 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LFVL--------- ------------------------------------------------------------ ----------------------------MSVSPP----PLPPKPPK----SPA------- ------------------------------------------------------------ --------------V--------ANSTAN---SGMSLQDAEWYWG---EISREEVNEKLR DTA-DGTFLVRDASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFS--- -SVVELVDH-YRNESLAQY----------NPKLDVKL---LFPVSKF-QQ---------- --DQ----V-VKE--GSIEAAG-KKLHEYNVQFQEKSREYDRLY--EDYTRTS------- -----QEIQMKR------------TAI--EAFNETIKIFEEQC--QTQERYSKEYIE--- KFKRE---------------GNEKE------IQ-RCV----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -- >A_carolinensis_ENSACAP00000012532 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LTLRFLLRHLATVAT--HAQSNGLCPRTLGEIFGPLLLRG------APS -------ARWV------------------------------------------------- ---RGPAESVADFPAVFLQTLLQNKDPETDLPAP----ALPPKPPK----PKP------- ------------------------------------------------------------ --------------V--------AGPLPNG-GNGTPLQDAEWYWG---DISREEVNEKLR DTP-DGTFLVRDASSKIQGEYTLTLR-KG---GNNKLIKIFHREGKYGF-SEPLTFG--- -SVVELINH-YRHESLAQY----------NAKLDTRL---LYPISKF-QQ---------- --DQ----V-VKE--DSVEAVG-EQLKAYHQQYQDKSREYDLLY--EEYTRTS------- -----QELQMKR------------TAI--EAFNETIKIFEEQC--QTQEKCSQDYME--- RFRRE---------------GNDKE------LQ-R------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -- >D_rerio_ENSDARP00000089169 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------LQDAEWYWA---DISREEVNEILH GMP-DGAFLVRDASCKVQGEYTLTVR-NN---GTNKLIRILHQEGKFGF-SEPLTFS--- -SVPELISF-YRHRSLVHY----------NTSLDVTL---AYPVTHC-NT---------- --DL----P-VKE--EFLSATR-EKLQECFRVFQ-KTAEYDQLY--DTCTSLL------- -----KEIQ-RR------------KAF--EDISMT-EISKPQC--YSQENFQNTLQK--- EYFTE---------------VNIEI------CS-RRSLNLANFEERIKCL-DVHL----N YD------IDYCLWILHFKKTSRNVNSLQC-----SL--KYLQKLKKAIN------LKLN K-FSVAQKLINKKMEFR-SKYPEI--------I-YFESG--C---EELL----REESWFV G----------------------------------------------DLARGPAEELLLG KPNGAFLIRNS-SSKDC------------------------------------------- -----------YACSVVVNSQ-VRH-CV-IRHTERGYGFVEPFDLHK---SLKDLVLHYS QTSLAQHNQAL-----------------------DVRLAYPVH----------------- -----------MSSVPTV------------------------------------------ -- >C_intestinalis_ENSCINP00000004274 -------------------------MSDQQPIYPHQSVPGIEYRMVADYEPQDKDRCIRC ------------------------------------------------------------ -----RANDTVIVKLPLNFAFTGTDKHPE------GWLYCTNLQTDETGYIPAEYVEYV- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QTVVPRPAPRERPLLPPVPEVVDEAEVPP----VIPPRCGSDSRPQVNSNYVPVP ------------------------------------------------------------ --------------INVNVSNGSNSPRPHRPSLSQSLQDQEWYWG---SVTREEVNAQLS DEQ-DGTFLVRNSANS-DREYTLTLR-KG---GSNKLIRIMSRNGMYGF-AEPLIFN--- -SVIQLVNH-YRNEPLTRY----------NPDLDITL---RYPAPKQ-QA---------- --TT----E-LSD--ESKEALF-RALLEDDKTFIKISDDYQDIF--ATFNARQ------- -----QDIQNMK------------TAI--SAYEETISMFKEQC--STLTTYMDQAQ---- --------------------GSHEE-------H-RLKENFRRMQTRLLFIVNQCE----D LR------TQLGQEIQENRERDRRLNSIKA-----DM--YQLKKLRDSRI------SHLK A-MRISEEVINNQLRID-EEDENE--------GVYHLPD--SVNLREKYPDHCVETNWFF P----------------------------------------------RYGRREADEVLRG TPNGTFLIRER-NGPPP------------------------------------------- -----------YACSLVANGK-VHH-CL-IEQTDDGYGFAEPFNLHL---TLSDLVLHYA HNSLIPHNETL-----------------------DTKLSIPVG----------------- -----------CVHRR-------------------------------------------- -- >A_aegypti_AAEL013596-PA ------------------------------------------------------------ ------------------------------------------------------------ -----MVSWLISFFELYFDLIVGLTIVYDGIDYTNNWTN--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---KTQIVYNTENHLRIMELLFYKLDWNEKLPEFASAPAVPPRKISRSTASLQQQQQPQS SQQQPFLQPIPGSSTSAAAYQSSSSSSGSLRKQPTITSPAAVIPSTLMVGPIYDTGSSGY GSCGSGSTAGDARGTA-------MFRMVGDADTPADLRAAEWYWG---NINRDEVKEKMT DVP-DGSFLVRDASSG-NGEYTLTLK-KD---GADRVIKIFHTQDKYGF-TRDGSHN--- -SVVDLINF-YRNVSLKEY----------NTILDIKL---MYPISRF-ED---------- --DT----Y-ISSTGDDTPRLA-QKFIEISQMLNDKLHERERLQ--EDLNMSK------- -----NQVDLKK------------QAQ--EAFIEAEKLFQDQL--AIQA----------- KFVSE---------------AQPHE------KQ-GISTNNKLIRDRMQELNQCRD----Q LQ------EDMKIEKTRIWQLERDINKLNP-----NI--MSLSKEKTSYI------EELK R-QGISESQIKQMET--------D--------GYFSHSH--G---SQEMP-HNDESTWLV P----------------------------------------------TFNRTDAEKELAS KPNGTFVIRPG--SGGP------------------------------------------- -----------YALSIKCNDT-VNH-CI-IQQTDRGYGFAEPYNIYD---SLKSLVLHYA TNSLEEHNDTL-----------------------QTTLKYPLL----------------- -----------APTRQQST----------------------------------------- -- >A_gambiae_AGAP005583-PA MTAVNMYDHVEVFKTKAIKGCDLPKLDRDKLEQMGIKNDFHQQSILTTITQLLMSAEMTA ------------------------------------------------------------ -----AAAAELPIVPAPVNLPVGTDQQQQQQQYNGHNLVNGSFSKQQKCDMCKNYLLGLV HQGLFCTQCNMVVHRQCSVMGLRPCSAAGTQQ--QQQSQ-QQSQQQSQQQSQQQQPTQQV GSTTGGYMLGGAYRQEHQHMFGKSLCLLFDVQQQAAPQIVVDLCTSLEKKAVMDKG-LDL YVVYRTTPLRYDEVNKLRDALN---ENLLNIDLNGYTPEC-VATVLKKFFHELPDPLIPV A---WYQSFIDASLLDDQ---------QAV--------------------------ERMK GIIQEMAPHHNKTLQYFMRHLIRICRLQFMRGNKQQPTMLLQNWCHILMRP------AWE -------------------R---------------------------------------- ---IVHFVANIKNHLRVLELLMYKIDWNEALPEFLSIPAVPPRKTSRTGSGAGTG----- ----------PGST-----------------KKSIIASPEGGSIGGPLLESDYSTTTTGS GS--SGNTLGRSAAQQYPNGGGMLMSLITDPNTPQELRDAEWYWG---KISRDVAKEKMM DAP-DGSFLVRDAIND-AGEFTLVLK-KD---GTDRPIKIYHKNGKYGF-TQECTFE--- -SLVGMINE-FRTTTLKEY----------NTILDISL---LYPISRF-ED---------- --ES----L-YPAAG-DIHQLA-ASFYETVQKLTDLQNMRESTL--EAFNVCQ------- -----SHMELRR------------QAQ--EAFIEADKLFNDQL--LTQA----------- RYEKE---------------AQPHE------QR-SLAQNRTLIESRLEELRKCKK----N LD------EDMERERERMRELQREAMKLKP-----EI--MNLSKQKDQYL------EALK R-QSITDAQIKQILK--------D--------GYLSTANPDG---TQELP-HLDETTWLR E----------------------------------------------RYSRQDAEKKLAN KPTGTFLIRAR--NAGH------------------------------------------- -----------YALSIACDGR-VNH-CI-IHQTERGYGFAEPYYIYD---SLKSLVVHYA TNSLEEHNDLL-----------------------QTTLKYPAF----------------- -----------APNMPSGSGSGSGSGSGSGSGQTSGGGGGGGGGSSSSRQQGSAPWSTSF AA >T_nigroviridis_ENSTNIP00000016459 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LE------EDLKKQAADYREIDKRMNSIKP-----DL--IQLRKTRDQYL------LWLT Q-KGVRQKKLNEWLGIK-NENTED--------Q-YSMVE--D---DEDLP-HQDEHSWKL G----------------------------------------------KINRLQAEALLQG KRGGTFLVRDS-SKAGC------------------------------------------- -----------YACSVV---------------PPHGYYFAEPYNLYS---SLKELVLHYQ HTSLVQHNDSL-----------------------NVTLAYPVY----------------- -----------AQQKR-------------------------------------------- -- >D_melanogaster_FBpp0077791 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MQPS----PLHYSTMR----PQA------- ------------------------------------------------------------ -----------------------PGSLVD--PNEDELRMAPWYWG---RISREEAKSILH GKP-DGSFLVRDALS-MKGEYTLTLM-KD---GCEKLIKICHMDRKYGF-IETDLFN--- -SVVEMINY-YKENSLSMY----------NKTLDITL---SNPIVRA-RE---------- --DE----E-SQPH-GDLCLLS-NEFIRTCQLLQNLEQNLENKR--NSFNAIR------- -----EELQEKK------------LHQ--SVFGNTEKIFRNQI--KLNESFMKAPAD--- APSTEAGGAGDGANAAASAAANANA------RR-SLQEHKQTLLNLLDALQAKGQ----V LN------HYMENKKKEELLLERQINALKP-----EL--QILQLRKDKYI------ERLK G-FNLKDDDLKMILQMGF-----D--------KWQQLYE--T---VSNQP-HSNEALWLL K----------------------------------------------DAKRRNAEEMLKG APSGTFLIRAR--DAGH------------------------------------------- -----------YALSIACKNI-VQH-CL-IYETSTGFGFAAPYNIYA---TLKSLVEHYA NNSLEEHNDTL-----------------------TTTLRWPVLYWKN----NPLQVQMIQ LQEEMDLEYEQAATLRPPPMMGSSAPIPTSRSREHDVVDGTGSLEAEAAPASISPSNFST SQ >O_anatinus_ENSOANP00000026019 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LE------EDLRAQAAEYREIDKRMNSIKP-----DL--IQLRKTRDQYLVGPRVGVGRA T-EGNRPTSLSPFVGLRWRHNQRS--------P-YSAVE--E---DEDLP-HQDERTWNV G----------------------------------------------SSNRGKAEALLRG KRDGTFLVRES-SKQGC------------------------------------------- -----------YACSVV---------------TPTGYGFAEPYNLYG---SLKELVLHYQ HTSLVQHNDSL-----------------------NVTLAYPVH----------------- -----------AQQRR-------------------------------------------- -- >C_elegans_Y110A7A.10 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------MSTTPGTPHGVTHSLMEQGWYWA---DADRSAVSKALS DQP-DGSFIVRNAST--PGDYTLSVK-FA---AQVKLLRIVVKDGKCGFNTDSLTHD--- -SVVRLIEF-HRNISLNIF----------NDALDVRL---LYPVSVR-RNSQNGKPFFKK GQLQQRMILSAKNDHDWRERLEMENLRAVHLAFERGAKLYDSAH--QEMERAESLYHALN QSVRDNEIKLGKLNNLLEAETDVVTQI--QGSQTTSEMLKGAF--ANNKTFVEESIR--- RINTELTS------------SKDKKKTLSGILD-EIAMKRSNSKTRLCKLMELRSAVYDK ME------PALCSRMAAMLDAGAEMINSEPTKVTQLLVDMELKWTPAQYL------MCGT SKENAANALIHARYRIA------------------------------------------- -------------------------------------------------QLDKAVGLKRE PQDGIFLIRGSSSHGDK------------------------------------------- -----------LVLSVLHGER-VSH-CL-IEQNEEGWGFEHSNVYLT---TISDFVRYYS HFSLETHADAI-----------------------KTPLRTPAFDAVTSDTSKPLRNGPGQ VFTALPISRKYMEKALLTDDPTKPPESPEPRPDSWDSPSPDTPSSSDSRLVHPTTLPKSI PE >A_aegypti_AAEL006949-PA ------------------------------------------------------------ ------------------------------------------------------------ -------------MRRLLHISISAPLTTRSRTLTISCPCFRSSRSVPTHSFPPNPIYARN HIQTIAAEKDYT------------------------------------------------ ------------------------KKNEFNLKRRQGPVLQEANNRKQVINKKTQSSYAAE HERDQKRRTI-------------------------------------------------- --------------------------------------------------------SSKV SECNSKKNNFSFNLKQKLCNIFRISKHQQYLRGKKSFLD--------------------- ------------------------------------------------------------ ---GHAKQNVCGTKSKSIDDYYKKSSVSTR--------KLPPLPMSAEKATVP------- ------------------------------------------------------------ ----NGISLEEAKDSNETHKQDEAAHIMDFTASIDKVKDCGWYWG---PISSEGAEKILS NEP-DGSFLVRDSSDD-HYIFSLTFK-LN---GSVRHVRIDQDQGTFSF-GSCAKFKSR- -TIMEFIENAVEHSRSGRYLFFLHRR-PEHGPLRVQL---TKPVSRF-KHVQSLQHLCRF VIHK----TIIRK--DLIQTLP---LPRRLLDYL------------NYKNCLS------- -----ERVEVDM------------TSH--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------FG QCVGDF------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -- >G_gallus_ENSGALP00000008738 -----------------------------------MPRKSVDYGELPEYEKSQIKRTLEL GTVMTVFSIKKSSLERRTIQVIMETRQVAWSKTADKIEGFLDLMEIKEIRPGKNSKDFER CKAKHREEHCFTIFYGTQFVLNTLSLAADSKGDADKWLCGLNILYQEVMRAPTPAITESW LRKQIYSVDQTRRNSISLRE-LKAVLPQVNFK--VSSMK-FLKDKFAEIGAHKEELSFEQ FHLFYKKIMFEQQKSILDEFKKDSSVFILGNTDRPDASAVHLHDFQRFLLHEQQESWAQD LSKVRERMTEFVDDTMRETAEPFLFVDEFLTYLFAKENSIWDEKYDTIDVQDMNNPLSHY WISSSHNTYLTGDQLRSESSTEAYIRCLRMGCRCIELDCWDGPDGKPIIYHGWTRTTKIK FDDVVQAIKDHAFVTSEYPVILSIEEHCSVEQQRHMAKVFKEVFGDQLLMK------PVE -------ASADQLPSPTQLKEKIIIKHKKLGPKGDIDVNLEDKKEEKKQQGELYMWDAIE QQWTRHYCAIADGKLSFSDVIEQNADEDSSKEVKRTELHLKEKWFH---GKMKEGRTTAE KLLQEYCAEMGGKDGTFLVRESEAFPNDCTLSFWRSGRVQHCRIRSSSDGDTVKYYLTDN VTFDSIYDLIQHYKEVHLRCAEFDLRLTDAVPNPSPHENKDWYYS---NLSRGEAEDMLM RIPRDGAFLIRKRDE--PDSFAMTFR-AE---GKVKHFRIQQEGRHFVL-GTSAYFE--- -SLVELVTY-YEKHPLYRK---------------MKL---RYPVTEE-LL---------- --ER----YSTEKDINSLYDVK-MYVEPSEITPTVPQRTVKALY--DYRAKRS------- -----DELSFSR------------GALIHNVTKETGGWWKGDYGEKVQHYFPSNYVE--- DLSSDNSAELESQIIEDNPLGSLCHGILVLNTYNVVKMPQGKHKKPFVFILEPKNPEDPC VEFATDKVEELFEWYQSVREITWKTAEEENRRKYWEKNQLIAIELSDLVIYCKPTSKTKD NLENPDFKEIRSFVETKAESIVKQKPVELLKYNLKGLTRVYPKGQRVDSSNYDPFRLWLC GSQMVALNFQTPDKYMQLNHALFSLNGHTGYVLQPESMRNEEYDPMPNESKRKLQMIMTV RVLGARHLPKLGRSIACPFVEVEICGAEYDNNKFKTTVVNDNGLNPVWAPCPEQVKFEIY DPNLAFLRFVVYEEDMFSDPNFLAHATFPIKGIKSGFRSVPLKNGYSEDIELASLLIHCE MQQVLEYEEELYSSCRQLRKRQEELNNQLFLYDTHMNLRNPNRDALL----REFNVNEHK LQMCQETCNRRLREKKVSNSKFYS------------------------------------ -- >T_guttata_ENSTGUP00000003436 ------------------------------------------------------------ ------------------------------------------------------------ -----RKHRLTRTQSAFSPLGFPSPFPGETVSLVDVDISQRGLSSPQPPTPPPPPRRSLS LLD--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------DFSGTLPPAVLLGPVGSSLQSFPLPP------PPPPHAADAFPRP------- ------------------------------------------------------------ ----APLRPPEAPGPPPLPCPLARPDPGSFAASLRELEKCGWYWG---PMNWEDAEMKLK GKP-DGSFLVRDSSDP-RYILSLSFR-SQ---GITHHTRMEHYRGTFSL-WCHPKFEDRC QSVVEFIKRAIMHSKNGKFLYFLRSRVPGLPPTPVQL---LYPVSRF-SNVKSLQHLCRF RIRQ----L-VRI--DHIPELP---LPKPLISYIRKFYYYDPQE--EQYLSLK------- -----EAQLISR------------QKQ--EPESST------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --