>H_sapiens_ENSP00000362994 ------------------------------------------------------------ -------MASSSGSSPRPAPDENEFPFGCPPTVCQDPKEPRALC---------------- -----------------------------CAGCLSENP-------RNGE--DQICPKCRG EDLQSISPGSRLRTQE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KAHPE--VAEA--GIGCPFAGVGCS---F-K-GSPQSV QEHEVTSQTSHLNLLL--GFMKQWKARLGCG--------------LESGPMALEQNLS-D LQLQAAVEVAGDLEVDCYRAPCSESQ----EELALQHFMKEKLLAELEGKLRVFEN---- IVAVLNKEVEASHLA----LATSIHQSQLD--------------RERILSLEQR------ --------------------VVEL-----QQTLAQKDQALGKLEQSL--R--LMEEASFD -G---------------TFLWKITNVTRRCHESACGRT--VSLFSPAFYTAKYGYKLCLR LYLNGDGTGK-RTHLSLFI--VIMRGEYDALLPWPFRNK---VTFMLLDQN----NR--- --EHAIDAFRPDL---SSA---SFQRP------------QSE-T--NVAS-GCPLFFPLS KLQSPKH-AYVKDDTMFL---KCIVE-TST------------------------------ ------------------------------------------------------------ --------------- >P_troglodytes_ENSPTRP00000036416 ------------------------------------------------------------ -------MASSSGSSPRPAPDENEFPFGCPPTVCQDPKEPRALC---------------- -----------------------------CAGCLSENP-------RNGE--DQICPKCRG EDLQSISPGSRLRTQE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KAHPE--VAEA--GVGCPFAGVGCS---F-K-GSPQSV QEHEVTSQTSHLNLLL--GFMKQWKARLGCG--------------LESGPMALEQNLS-D LQLQAAVEVAGDLEVDCYRAPCSESQ----EELALQHFMKEKLLAELEGKLRVFEN---- IVAVLNKEVEASHLA----LATSIHQSQLD--------------RERILSLEQR------ --------------------VVEL-----QQTLAQKDQALGKLEQSL--R--LMEEASFD -G---------------TFLWKITNVTRRCHESACGRT--ISLFSPAFYTAKYGYKLCLR LYLNGDGTGK-RTHLSLFI--VIMRGEYDALLPWPFRNK---VTFMLLDQN----NR--- --EHAIDAFRPDL---SSA---SFQRP------------QSE-T--NVAS-GCPLFLPLS KLQSPKH-AYVKDDTMFL---KCIVE-TST------------------------------ ------------------------------------------------------------ --------------- >P_pygmaeus_ENSPPYP00000021917 ------------------------------------------------------------ -------MASSSGSSPRPAPDENEFPFGCPPTVCQDPKEPRALC---------------- -----------------------------CTGCLSENP-------RNGE--DQICSKCRG EDLQSISPGSRLRTQE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KAHPE--VAEA--GVGCPFAGVGCS---F-K-GSPQSV QEHEVTSQTSHLNLLL--GFMKQWKARLGCG--------------LESGPMALEQNLS-D LQLQAAVEVAGDLEVDCYRAPCSESQ----EELALQHFMKEKLLAELEGKLRVFEN---- IVAVLNKEVEASHLA----LATSIHQSQLD--------------RERILSLEQR------ --------------------VVEL-----QQTLAQKDQALGKLEQSL--R--LMEEASFD -G---------------TFLWKITNVTRRCHESACGRT--VSLFSPAFYTAKYGYKLCLR LYLNGDGTGK-RTHLSLFI--VLMRGEYDALLPWPFRNK---VTFMLLDQN----NR--- --EHAIDAFRPDL---SSA---SFQRP------------QSE-T--NVAS-GCPLFFPLS KLQSPKH-AYVKDDTMFL---KCIVE-TST------------------------------ ------------------------------------------------------------ --------------- >M_mulatta_ENSMMUP00000026496 ------------------------------------------------------------ -------MASSSGSSPRPAPDENEFPFGCPPTVCRDPKEPRALC---------------- -----------------------------CTGCLSENL-------RNSE--DQICPKCRG EDLQSVSPGSRLRTLE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RAHPE--VAEA--GVGCPFAGVGCS---F-K-GSPQSV QEHEVTSQTSHLNLLL--GFMKQWKTRLGSG--------------LESGPMALEQNLS-D LQLQAAVEVAGDLEVDCYRAPCSESQ----EELALQHFMKEKLLAELEGKLRVFEN---- IVAVLNKEVEASHLA----LATSIHQSQLD--------------RERILSLEQR------ --------------------VVEL-----QQTLAQKDQALGKLEQSL--R--LMEEASFD -G---------------TFLWKITNVTRRCHESACGRT--VSLFSPAFYTAKYGYKLCLR LYLNGDGTGK-RTHLSLFI--VIMRGEYDALLPWPFRNK---VTFMLLDQN----NR--- --EHAIDAFRPDL---SSA---SFQRP------------QSE-T--NVAS-GCPLFFPLN KLQSPKH-AYVKDDTMFL---KCIVE-TST------------------------------ ------------------------------------------------------------ --------------- >E_caballus_ENSECAP00000009372 ------------------------------------------------------------ -------MASGSASSPRPAPDENEFPFGCPPTVCEDPSEPRALC---------------- -----------------------------CAACLSENS-------RNGE--DRVCLKCRG DDSQSVGPGS-LVSQE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KVHSD-AVAEA--GVGCPFAGVGCS---F-K-GSPKFM QEHEVASQATHLNLVL--GFMKQWKAQLGSG--------------LGSGPMALEQNLS-D LQLQAAVEVAGDLEVDCYRAPCSESQ----EELALQHFMKEKLLAELEGKLRVFEN---- IVAVLNKEVEASHLA----LAASIHQSQLD--------------REHILSLEQR------ --------------------VLEL-----QQTLAQKDQALGKLEQSL--R--LMEEASFD -G---------------TFLWKITNVTRRCHESACGRT--VSLFSPAFYTAKYGYKLCLR LYLNGDGTGK-RTHLSLFI--VIMRGEYDALLPWPFRNK---VTFMLIDQN----NR--- --EHAIDAFRPDL---NSA---SFQRP------------QSE-T--NVAS-GCPLFFPLS RLQSPKH-AYVKDDTMFL---KCIVE-TSA------------------------------ ------------------------------------------------------------ --------------- >B_taurus_ENSBTAP00000041215 ------------------------------------------------------------ -------MASGSASSPRPAPDENEFPFGCPPTACQDPPEPGPVC---------------- -----------------------------CAVCLSEKV-------RNDE--DRICPKCKG DDTPSESPGS-LLSQE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KDHPE--VAEA--GVGCPFAGVGCS---F-K-GSPKFM EEHEVTSQAAHLNLLL--GFMKQWKAQLGSG--------------LGYGPMALERNLS-D LQLQGAVEVAGDLEVDCYRAPCSESQ----DELALHHFMKEKLLNELEGKLCVFEN---- IVAVLNKEVEASHLA----LAASIHQSQLD--------------REHILSLEQR------ --------------------VLEL-----QQTLAQKDQALGKLEQSL--R--LVEEASYD -G---------------TFLWKITNVTRRCHESACGRT--VSLFSPAFYTAKYGYKLCLR LYLNGDGTGK-RTHLSLFI--VIMRGEYDALLPWPKKGE---VTFMLLDQN----NR--- --EHAIDAFRPDL---NSA---SFQRP------------QSE-T--NVAS-GCPLFFPLN KLQSPKH-AYVKDDTMFV---KCVVD-TNT------------------------------ ------------------------------------------------------------ --------------- >M_musculus_ENSMUSP00000028234 ------------------------------------------------------------ -------MASSS------APDENEFQFGCPPAPCQDPSEPRVLC---------------- -----------------------------CTACLSENL-------RDDE--DRICPKCRA DNLHPVSPGS-PLTQE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KVHSD--VAEA--EIMCPFAGVGCS---F-K-GSPQSM QEHEATSQSSHLYLLL--AVLKEWKSSPGSN--------------LGSAPMALERNLS-E LQLQAAVEATGDLEVDCYRAPCCESQ----EELALQHLVKEKLLAQLEEKLRVFAN---- IVAVLNKEVEASHLA----LAASIHQSQLD--------------REHILSLEQR------ --------------------VVEL-----QQTLAQKDQVLGKLEHSL--R--LMEEASFD -G---------------TFLWKITNVTKRCHESVCGRT--VSLFSPAFYTAKYGYKLCLR LYLNGDGSGK-KTHLSLFI--VIMRGEYDALLPWPFRNK---VTFMLLDQN----NR--- --EHAIDAFRPDL---SSA---SFQRP------------QSE-T--NVAS-GCPLFFPLS KLQSPKH-AYVKDDTMFL---KCIVD-TSA------------------------------ ------------------------------------------------------------ --------------- >O_cuniculus_ENSOCUP00000004916 ------------------------------------------------------------ -------MASSSASSPRPAPDENEFPFGCPPSAFQDPAEPRALC---------------- -----------------------------CTACLSE-L-------RNCE--DRICPACKG DNPTSVSPGS-LRTQE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KXXXX--XXXX--XXXXXXXXXXXX---X-X-GNAQSL QEHEATSQASHLNLLL--GFMKQWKAQLGSG--------------LGSGPMALERNLS-D LQLQAAVEVAGDLEVDCYRAPCSESQ----EELALQHLMKEKLLAELEGKLRVFEN---- IVAVLNKEVEASHLA----LAASIHQSQLD--------------RERILSLEQR------ --------------------VVEL-----QQTLAQKDQALGKLEQSL--R--LMEEASFD -G---------------TFLWKITNVTRRCLESACGRT--VSLFSPAFYTAKYGYKLCLR LYLNGDGTGK-RTHLSLFI--VIMRGEYDALLPWPFRNK---VTFMLLDQN----NR--- --EHAIDAFRPDL---SSA---SFQRP------------QSE-T--NVAS-GCPLFFPLN KLQSPKH-AYVKDDTMFL---KCIVE-TSA------------------------------ ------------------------------------------------------------ --------------- >C_familiaris_ENSCAFP00000031262 ------------------------------------------------------------ -------MASGSASSPRPAPDENEFPFGCPPDACQEPAEPRAVR---------------- -----------------------------CAACLPENV-------RSGE--DRICPKCQG DDPQSGSPGS-PLSQE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KDPPE--VAEA--EVGCPFAGVGCP---Y-K-GSPRLM QEHEVASQTTHLNLLL--GCVTPWMAPRGPG----------------GAALALERNLS-D LQLQAAVEVAGDLEVDCYRAPRSDSQ----DEHTLQRLTKEKPLAELQEKLRVFEN---- IVAVLNKEVEASHLA----LAASIHQSQLD--------------REHILSLEQQ------ --------------------VAKA-----LHLCAVKAQWSVLPLLSH--R--EQEDHSFV WA---------------RSWWKITNVTFRCHESACGRT--VSLFSPAFYTAKYGYKLCLR LYLNGDGTGK-RTHLSLFI--VIMRGEYDALLPWPFRNK---VTFMLLDQN----NR--- --EHAIDAFRPDL---SSA---SFQRP------------QSE-T--NVAS-GCPLFFPLS RLQSPKH-AYVKDDTMFL---KCIVE-TNA------------------------------ ------------------------------------------------------------ --------------- >G_gorilla_ENSGGOP00000002249 ------------------------------------------------------------ -------MASSSGSSPRPAPDENEFPFGCPPTVCQDPKEPRALC---------------- -----------------------------CAGCLSENP-------RNGE--DQICPKCRG EDLQSISPGSRLRTQE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KAHPE--VAEA--GVGCPFAGVGCS---F-K-XXXXXX XXXXXXXXXXXXXXXX--XXXXXXXXXXXXX--------------XXXXXXXXXXXXX-X XXXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXVFEN---- IVAVLNKEVEASHLA----LATSIHQSQLD--------------RERILSLEQR------ --------------------VVEL-----QQTLAQKDQALGKLEQSL--R--LMEEASFD -G---------------TFLWKITNVTRRCHESACGRT--VSLFSPAFYTAKYGYKLCLR LYLNGDGTGK-RTHLSLFI--VIMRGEYDALLPWPFRNK---VTFMLLDQN----NR--- --EHAIDAFRPDL---SSA---SFQRP------------QSE-T--NVAS-GCPLFFPLS KLQSPKH-AYVKDDTMFL---KCIVE-TST------------------------------ ------------------------------------------------------------ --------------- >M_domestica_ENSMODP00000024498 ------------------------------------------------------------ -------LTDTAPVGPHLIPDENEFPFGYPASICQGTPEPKYLCCGCHNVLKKAQQT-L- ------------------------CGHRYCAACLSWIL---------------------- ---SSPNDGT-LFFWG--FFQNSL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------VPAED--QDRCPFADIGCS---F-K-GGQERV KEHEASSLSDHLRRLL--ELVIRTKVQAGPS---RGRGASGRRQAAEPEPKAPERNLS-D LQLQGAVEVNGDLEADYFHAASSDSE----EELALQRFMKEKLLSELEEKLRVFEN---- IVTVLNKEVEASHLA----IAASVHQSGLT--------------QDLILSLEQR------ --------------------VVDL-----QQTLTQKDLALTKLEQTL--H--LLEEASYD -G---------------VYLWKITNFTRRCHESACGRT--VSLFSPAFYTARYGYKLCLR IYLNGDGMGK-GTHLSLFI--VVMKGKYDALLEWPFRNKAIPVTFMLLDQN----NR--- --EHVTDSFHPDL---TSG---SFQKP------------QGE-S--NIAS-GRPMFFPLN KLQSSKH-AYVKDDTLFL---KCVIE-TNS------------------------------ ------------------------------------------------------------ --------------- >O_anatinus_ENSOANP00000001757 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------AFSDAAINKEISELNVHCVTPG--CSWTGLMKNFE------- ------------------------------------------PQDH--Q-AECDCALIPC HA------GCGLMIMRKK----LPD----HLENGCAKSPTTCLKCKQTFCSMEY------ ------------------------------------------------------------ --------------------QFNSPGS-TASRI--QDGCPFSVIGCS---FMH-GSREKV KEHETSSMDMHLGLLL--QAVSQTKANQGDC----------------------------- -----------------------------EEELALQRFMREKLISDLEEKLHVFEN---- IVAVLNKEVESSNMA----IAASIHQSNLD--------------RDMILRLEQR------ --------------------VLDL-----HQTLAQKDLALARLKQSL--Q--FSELASYD -G---------------IYLWKITDFSRKCHESLCGRT--TSLFSPVFYTARYGYKVCLR VYLNGDGTGK-GTHISLFF--VIMKGEYDSLLQWPFRNK---VTFMLLDQN----NR--- --EHVIDAFRPDL---NSA---SFQKP------------QGE-M--NVAS-GCPMFFPLN KLQSPKH-AYVKDDTLFL---KCIIE-TNS------------------------------ ------------------------------------------------------------ --------------- >T_guttata_ENSTGUP00000006737 ------------------------------------------------------------ -----------------------------------DVPGHKFLCSNCNNILKKALQT-L- ------------------------CGHRYCSACLAWIL-------RNNK--NAICQKCKE EDPNTLGEESLLAEER--AFGDAAINKEISELRVHCVTLG--CSWSGIMKDFE------- --------------------------------------------EH--Q-SLCEYALIPC HT------GCGHVVMRRK----LAD----HLENGCVNNVTVCQQCQCSLATSEC-Q--VR ---------------------------------------------------------TFL SQ--IKA--FQLVLIISSTFFFSSH-S-TSSSN--KDGCCFSEVGCA---F-R-GSKEKI QEHQNSAVGAHMLLLL--QHMRQLQGTL-------------------------------- ------------------------C-----SKGFSPRPELNKVISELENKLHVFEN---- IVAVLNKEVESSNLE----IQAFRRQSELD--------------QNVIRGLELK------ --------------------IAEL-----HQCLTQKDAGLSSLHKSL--L--FSEQASYD -G---------------IFLWKITEVARKLQDSVTGRT--VSLYSPAFYTAKYGYKVCLR VYLNGDGTGK-GTHMSLFF--VVMKGDYDALLPWPFRHK---VTFMLLDQN----NR--- --EHIIDAFRPDL---TSA---SFQRP------------VND-M--NVAS-GCPMFLPLA KLQSPKH-GYVREDTLFL---KCIIE---------------------------------- ------------------------------------------------------------ --------------- >G_gallus_ENSGALP00000002401 ------------------------------------------------------------ PRAGPAGGPGADAAVLP----------GGSRRGVGDVPEQKYLCSNCNNVLKKALQT-L- ------------------------CGHRYCSACLSWIV-------RNNK--NPVCQKCKE EDPSTLSEGSLLAEER--AFGDAAINKEISELRVHCVTLG--CSWCGTMKNFE------- --------------------------------------------EH--Q-ILCEYALIPC HT------GCGHVVMRKK----LAD----HLENGCVNNVTVCHKCKQSLSSSEY-Q--PH ---------------------------------------------------------CPR KPKVCRS--EPAVILMTGTFMLSDHLR-ASSVS--MDGCRFSEVGCS---F-G-GSKEKI KEHEKAAVGTHMLLLL--QYIKQLKANLCTV----------------------------- --------------------------------SKAANGFISQTELNLENKLHVFEN---- IVAVLNKEVETSNLE----ITAFRRQSELD--------------QNVIRGLELK------ --------------------IAEL-----HHCLTQKDAGLSRLHKSL--V--FSEQTSYD -G---------------VFLWKITDVNQKLQDSVTGRV--VSLYSPAFYTAKYGYKVCLR IYLNGDGMGK-GTHVSLFF--VVMKGDYDALLPWPFRHK---VTFMLLDQN----NR--- --EHIIDAFRPDL---ASA---SFQRP------------VND-M--NVAS-GCPTFLPLT KLQSPKH-AYVKEDTLFL---KCIID-LTAV----------------------------- ------------------------------------------------------------ --------------- >D_rerio_ENSDARP00000091948 -------SGS-------------------------------------------------- ----ASDPSLNGVSSTP----------GFPQSICDEVPKDKYLCSNCNNVLNKARQT-V- ------------------------CGHRYCLACVNWLV-------RNNK--DLVCTKCKG EDSNVESDTSVLTPNQ--FFNDVAINKEILDLKVHCANQG--CPWRSTLKNFE------- -------------------------------------------QDH--Q-SQCEYALIPC NI------GCGIMVQRKT----LAT----HLESGCPNNKTACPSCTSVLTPREL-Q--V- --------------------------------------------------------LLKK EKHVCPS--SGDKKTAKTDKKQKNNQP-ANSKK--KEPCIFSDVGCP---F-K-GNPDKV KEHESCSHAGHLQLLL--DVTRALQRTLNSA---TERVYQDSPVFLEPGPNGSSLAPQ-A DGDIETDGGD-----------------------PGVELAAGQQLDALQQKVQVIEN---- IISALNREVEKTQIS----VVAMNRDHCNS--------------QQIIQHLEAT------ --------------------VAEL-----QQRLVRKDILISSLQQSI--S--AQQDVSYD -G---------------TFYWRVCDVSQKQREAANSQK--ISQYSPAFYTARYGFKVCLR LYLNGDGAGK-GSHISLFF--VIMKGEYDPILSWPFKHK---VTFFLLDQN----QR--- --EHVIDAFRPDL---SSM---SFHQP------------VSD-M--NVAS-GCPLFFPLK KLRSPKH-AYCKDDTIYI---KCVVD-TSS------------------------------ ------------------------------------------------------------ --------------- >T_nigroviridis_ENSTNIP00000011878 ------------------------------------------------------------ --MARISLDCS--PSLP----------GIPLSVLSVPMENKYKCQQCLQVLRKPVQA-Q- ------------------------CGHRFCVHCFRELT-------SSGP---KPCEACRQ EEIYEEPTSI-LNSNE--VFPDNAAGREIASLPARCLNQD--CSWTGSIKQYE------- -------------------------------------------AQH--E-GRCEFEQIKC DA-------CQAFVLRAE----KDR----HNERECEARTLNCKYCKFTFHFKDI-K--AH D------------------------------------------------------EICSK FPLQCKD--CGK--KKIPREKFNEHIK-SCAKS--KSACPFSEVGCK---S-V-VENGKL SEHENSSTMEHMRLLL--PIVLSLTQARAEV----------------------------- ---SDSGEWQEDSVLGLYRAPEEGVH-------VGAGAAASVH-VNLEKKVTALER---- IVCVLNREVERSTAM----LEAFAHQHALD--------------QEKIENLSTK------ --------------------LGQL-----ERVIAMRDLQLSETEQMV--R--ELQSCTYD -G---------------IFVWKISEFSRRRQEAVAGRT--PAMFSPAFYSSKYGYKMCLR LYLNGDGTGR-GTHLSLFF--VVMKGKCDALLKWPFSQK---VTLMLLDQN----NR--- --EHIIDAFRPDV---TSS---SFQRP------------ISE-M--NIAS-GCPLFCPLA KLAG-KS-PYLKDDTIFI---KAIVD-LTGL----------------------------- ------------------------------------------------------------ --------------- >T_rubripes_ENSTRUP00000015632 -------------------------------------------------TDAMA------ --TQEPSPPSSMESNKP----------GFPKKILGNKLEDKHLCNCCHNILRRPFQA-Q- ------------------------CGHRFCSYCFNRTV-------SNGP---QKCSACIK RILWFQ------------AFPDNAVRREVEHLPAACINEN--CTWKGTIKEYE------- -------------------------------------------LNH--E-GKCEFMIISC PS-------CKEHIRFNE----QER----HNERECPERTLNCKYCKEPFHFKNI-K--AH D------------------------------------------------------EICPK YPMICEG--CAK--KKIPREKYVDHIK-FCSKF--RTPCRFHVVGCD---M-S-VEKEKI HDHERAYAYEHLNLLL--HYIMGMKVSMEGL---QPQGLEVAGQKLVELQQSL-RELE-L SVS--TSFTPLPSSVGAALELQLHSE-------KTKVAELGRRCTELEVKANTFEN---- VVCVLNREVERFATT----MEASNRQHKLD--------------QDKIEALSNK------ --------------------VRQL-----ERTVGLKDLTVAEMEGRL--R--EMSATTFD -G---------------VFVWRISDFAKKRQDAIAGRA--PAMFSPAFYTSKYGYKMCLR IYLNGDGTGR-GSHLSLFF--VVMRGQSDALLKWPFNQK---VTLMLLDQS----NR--- --EHIIDAFRPDV---TSS---SFQRP------------VSE-M--NIAS-GCPLFCPLS KLDG-KN-SYIRDDTIFI---KAIVD-LTGL----------------------------- ------------------------------------------------------------ --------------- >D_rerio_ENSDARP00000069217 -------------------------------------------------MISAAGTLCKW KDMERPSLPSSLDSTLP----------GISREVLSVSMEPKYQCQQCKDILRKPFQA-Q- ------------------------CGHRFCVFCFKQLT-------SSGP---IPCEACRA EGIFEEETSV-LNIAV--AFPDNAARREIDSLPAKCPNEG--CSWSGTLKDFE------- -------------------------------------------NQH--E-GRCAFERVKC EA-------CQVLILLSE----KDR----HNERECEARTLNCKYCKVTFNFKEI-K--AH D------------------------------------------------------EICQK FPMQCKD--CGK--KKIPREKFQEHTK-SCAKS--KSACQFREIGCR---A-V-VDNCKQ QEHEQTSIMEHLRLML--ALLSSMRLRA-------------------------------- ---EGAGEWQEDVGLGLYRGPEDAPP-------AGAHNVGRGGGPGVQKKVTTLEN---- IVCVLNKEVERSALT----MEAISRQHRLD--------------QEKIENLSNK------ --------------------VRQL-----ERTLTTRDLQLAESEQSL--R--ELQFCTYD -G---------------VFIWKIAEFSRRRQDAVAGRA--PAMFSPAFYSSKYGYKMCLR LYLNGDGTGR-GSHLSLFF--VVMKGKYDALLKWPFSQK---VTLMLLDQN----NR--- --EHIIDAFRPDV---SST---SFQRP------------ISE-M--NIAS-GCPLFCPLA KLAG-KS-SYLRDDTIFI---KAIVD-LTGL----------------------------- ------------------------------------------------------------ --------------- >T_rubripes_ENSTRUP00000047803 ------------------------------------------------------------ --MARISMDCS--SSLP----------GIPLSVLSVPMENKYKCQQCLQVLRKPVQA-Q- ------------------------CGHRFCIHCFKELT-------SSGP---KPCEACRQ EEIYEEPISV-LNSNE--VFPDNAAGREIASLPARCLNQG--CSWTGSIKQYE------- -------------------------------------------AQH--E-GRCELEQIKC DA-------CQASVLRAE----IDR----HNERECEARTLNCKYCKLTFHFKDI-K--AH D------------------------------------------------------DICLK FPLPCKD--CGK--KKIPREKFNEHIR-SCAKS--KSACPFSEVGCK---S-V-VDNGKL REHEHSSTVEHLHLLL--PMVLSLTRTRAEV----------------------------- ---SESGEWQEDSGLGLYRAPEEGVN-------VGAGAAASVHAVDLEKKVTALEN---- IICVLNREVERSALK----VEAFAHQHCLD--------------QEKIENLVSK------ --------------------VGQL-----ERAIAMRDLQLSETEQMV--R--ELQSCTYD -G---------------IFVWKISEFSRRRQEAVAVRM--PTMFSPAFYSSKYGYKMCLR LYLNGDGTGR-GTHLSLFF--VVMRGKCDALLKWPFSQK---VTLMLLDQN----NR--- --EHIIDAFRPDV---TSS---SFQRP------------ISE-M--NIAS-GCPLFCPLA KLAG-KS-PYLKDDTIFI---KAIVD-LTGL----------------------------- ------------------------------------------------------------ --------------- >O_latipes_ENSORLP00000020860 ------------------------------------------------------------ --QQEPSPPSSLEGSKP----------GFPRKILANCLEDKHLCNSCEKILRRPLQA-Q- ------------------------CGHRFCCFCFNRTV-------SSGP---QKCSACIK EDLFEEPTSI-LKQGG--AFHDNAARREVEALAAVCPNEG--CTWTGTVKEYE------- -------------------------------------------ASH--E-GSCDFTIIMC PS-------CKELMRANE----QER----HNERECPERTLNCKYCKEPFLLKNI-K--AH D------------------------------------------------------EICPK YPMMCEG--CAK--KKIPREKYVDHIK-FCSKF--KAPCRFHVVGCD---T-S-VEKEKI HDHERQCSYEHLNLLL--HFIMGIKGVCAAT---LATS-------FTPLHSAMGAALE-- --------------------LQLQSE-------KTKVAELSRRCQELELKVSTFEN---- IVCILNRELERSCAT----MEAYNRQHRLD--------------QDKIEILSNK------ --------------------VRQL-----ERTVSLRDLSIVEMEGKM--K--DMSAATYD -G---------------IFIWKISDFTKKRQDAMAGRA--PAMFSPAFYTSKYGYKMCLR IYLNGDGTGR-GTHLSLFF--VVMRGHSDALLKWPFNQK---VTLMLLDQN----NR--- --EHIIDAFRPDI---SSS---SFQRP------------VSD-M--NIAS-GCPLFCPLS KLDS-KN-SYIRDETIFI---KAIVD-LSGL----------------------------- ------------------------------------------------------------ --------------- >T_rubripes_ENSTRUP00000011363 ------------------------------------------------------------ --SQEPSPPSSLEGNKP----------GFPKKILANNLENKHLCKSCQKVLRRPLQA-Q- ------------------------CGHRFCSFCFHKIV-------SAGP---QTCSACIS EDLFEEPASI-LKLGG--AFPDNAARREVEALAAVCPNEG--CIWTGTIKEFE------- -------------------------------------------ARH--E-DSCDFMIILC PS-------CKELMRVNE----QER----HNERECPERTLNCKYCKDPFQLKNI-K--AH D------------------------------------------------------EICPK YPMICEG--CSK--KKIPREKYVDHIK-YCSKF--KSPCRFHVVGCN---T-S-VEKEKI HDHERQCSYEHLNLLL--HFIMGIKISLESL---PPQSLDVASHKLLELHQSL-RDLE-- --------------------LKLQSE-------KTKVAELSRRCQDLELKVRTFEN---- IVCVLNREVERSCTT----MEAYNRQHRLD--------------QDKIEILNNK------ --------------------VRQL-----ERTVSLRDLSIVEIDEKM--R--ELSAATYD -G---------------VFVWKISDFTKKRQDAVAGRA--PAMFSSAFYTSKYGYKMCLR IYLNGDGTGR-GTHLSLFF--VVMRGHSDALLKWPFNQK---VTLMLLDQN----NR--- --EHIIDAFRPDI---SSS---SFQRP------------VSD-M--NIAS-GCPLFCPLP KLDC-KN-SYIRDDTIFI---KVIVD-LTGL----------------------------- ------------------------------------------------------------ --------------- >O_latipes_ENSORLP00000003220 ----------------------------------------------------MA------ --ALEPSPPSSMESNKP----------GFPKKILGNKLEDKHLCNCCHNILRRPIQA-Q- ------------------------CGHRFCSYCFNRTV-------SNGP---QKCNACIK EEIFEEPTSI-LKQGC--AFPDNAVRREVEGLSADCINEN--CPWKGTIKEYE------- -------------------------------------------LDH--E-GKCEFMIIPC PS-------CKERIRFSE----QER----HSERECPERTLNCKYCKEPFHFKNI-K--AH D------------------------------------------------------EICPK YPMICEG--CAK--KKIPREKYVDHIK-FCSKF--RTPCRFHVVGCD---M-S-VEKEKI HDHERAFAYEHLNLLL--HYIMGMKVSMEGL---QPQGLETAGHKLVELQKSL-RDLE-A RVSQLSTTSSGP---------------------PVQGAAASSSSSRLEVKSGTFEN---- VVCVLNREVERFTTT----MEASNRQHKLD--------------QDKIEALSNK------ --------------------VRQL-----ERTVGLKDLTVAEMEGRL--R--EMAATTFD -G---------------VFIWRISDFAKKRQDAVAGRA--PAMFSPAFYTSKYGYKMCLR IYLNGDGTGR-GTHLSLFF--VVMRGLSDALLKWPFNQK---VTLMLLDQS----NR--- --EHIIDAFRPDV---TSS---SFQRP------------VSE-M--NIAS-GCPLFCPLS KLDA-KN-SYIRDDTIFI---KAIVD-LTGL----------------------------- ------------------------------------------------------------ --------------- >G_gallus_ENSGALP00000014649 ----------------------------------------------------MA------ --AANSTPPGSLDLSQP----------GFAKEILGTKLEVKYLCSDCRNILRRPFQA-Q- ------------------------CGHRYCSYCLKKII-------SSGP---QKCASCIQ EGIYEEGISI-LETSS--AFPDNAARREVESLPAVCINEG--CTWKGTIKEYE------- -------------------------------------------SCH--E-GNCPFLLIEC QA-------CRGVIPLNE----KER----HSERECPERTLNCKYCKSLFYFPDI-K--AH D------------------------------------------------------EVCPK FPLTCDG--CGK--KKIPREKFQDHVK-NCGKC--KVPCRFKVVGCA---E-M-VENEKL PEHESKCLAEHLYMLL--SFVLSLKSGSGDL---KHLPAIPSSQSSSPLLAANSLCPE-- ------------------------SE-------LFKSLELLGRCDALEKKTVTFEN---- IVCVLNREVERVSLT----AEAYSRQHRLD--------------QEQIETLSNK------ --------------------VRQL-----ERSIGLKDLAMAEMEEKI--R--NMEASTYD -G---------------VFIWKITEFARKRQEAITGRS--PAIFSPAFYTSKYGYKMCLR VYLNGDGTGR-GTHLSLFF--VVMKGPNDALLRWPFNQK---VTLMLLDQN----NR--- --EHIIDAFRPDV---TSS---SFQRP------------VTE-M--NIAS-GCPLFCPVS VMEA-KN-SYVRDDAIFI---KAIVD-LSGL----------------------------- ------------------------------------------------------------ --------------- >C_familiaris_ENSCAFP00000028895 ----------------------------------------------------MA------ --AASVTPPGSLDLLQP----------GFSKTLLGTKPEDKYLCSACRNVLRRPFQA-Q- ------------------------CGHRYCSYCLSSIL-------SSGP---QNCAACVH EGIYEEGISI-LESSS--AFPDNAARREVESLPAVCPNNG--CTWKGTLKEYE------- -------------------------------------------SCH--E-GHCPFMLTEC PA-------CKGLVRLGE----KEH----HSEHECPERSLSCRHCRAPCCWADL-K--AH H------------------------------------------------------EVCPK FPLTCDG--CGK--KKISREKFQDHVR-ACGKC--RVPCRFHVVGCP---E-M-VESEKQ QQHEAHWLREHLAMLL--GSLLEAKHLSGAG----------------------------- ------------------------GP-------F-LGLKLQQRCEALERKTATFEN---- IVCVLNREVERVAMT----AEACGRQHQLD--------------QDRIEALSNK------ --------------------VQQL-----ERTIGLKDLAMAELEQKV--H--EMEASTFD -G---------------VFIWKISDFARKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLR IYLNGDGTGR-GTHLSLFF--VVMKGPNDALLRWPFNQK---VTLMLLDQN----NR--- --EHVIDAFRPDV---TSS---SFQRP------------VSD-M--NIAS-GCPLFCPVS KMEA-KN-SYVRDDAIFI---KAIVD-LTGL----------------------------- ------------------------------------------------------------ --------------- >M_domestica_ENSMODP00000021625 ----------------------------------------------------MA------ --TANSTPPGSLDLLQP----------GFSKDILGTKLEDKYLCSACKNILRRPFQA-Q- ------------------------CGHRYCSYCLTSII-------STGP---QNCAACIQ EGIYEEGISI-LESSS--AFPDNAARREVESLPAVCVNDG--CTWKGTIKEYE------- -------------------------------------------SCH--E-GHCSFMLIEC PA-------CKWMIKLGE----KEH----HSERECPKRSLNCRYCKALFYYPDI-K--AH D------------------------------------------------------EICPK FPLTCEG--CGK--KKILREKFQDHVK-ACGKC--KGPCKFHVVGCT---E-M-VENEKQ QDHENQKVAEHLCMLL--NFVLEARHFHGDI----------------------------- -------------------------E-------MSKSTELLERCETLERKTVTFEN---- IVCVLNREVERVSMT----AEACSRQHRLD--------------QEKIETLSSK------ --------------------VQQL-----ERSIGLKDLAMADMEQKI--L--EMEASTYD -G---------------IFIWKITDFARKRQEAMAGRS--PAIFSPAFYTSKYGYKMCLR IYLNGDGTGR-GTHLSLFF--VVMKGPNDALLRWPFNQK---VTLMLLDQN----NR--- --EHVIDAFRPDV---TSS---SFQRP------------VSD-M--NIAS-GCPLFCPVS KMES-KN-SYVRDDAIFI---KAIVD-LTGL----------------------------- ------------------------------------------------------------ --------------- >D_rerio_ENSDARP00000043465 ------------------------------------------------------------ --AQEPSPPSSLEGNKP----------GFPKKILANKLEDKHLCNICLKILRRPFQA-Q- ------------------------CGHRFCSYCFNKAV-------SKDK---KVCTTVV- --------IM-KKKKK--AFPDNAAKREVEALEAVCINEE--CSWTGTIKEYE------- -------------------------------------------ANH--E-GKCDFRILPC PS-------CKELLRANE----LER----HNERECPERTLNCKYCKEPFHFKNI-K--AH D------------------------------------------------------EICPK YPMICEG--CAK--KKIPREKYVDHIK-LCTKF--RTPCRFHVVGCD---M-T-VEKEKI HDHEQACSYEHLNLLL--HFIMGIKVNLESL---QPQSLELASHKIHELHQSL-RELE-- ----------------------------------------LKMGQELELKVNTFEN---- IVCVLNREMERSATT----MEAYNRQHRLD--------------QDKIEILNNKIESNQG IKCEADNSCFSPRNYWMFVQVRQL-----ERTVGLRDLSIVEMEAKM--R--EMSAATYD -G---------------VFVWKISDFSKKRQDAVAGRA--PAMFSPAFYTSKYGYKMCLR IYLNGDGTGR-GTHLSLFF--VVMRGHSDALLKWPFNQK---VTLMLLDQN----NR--- --EHIIDAFRPDI---SSS---SFQRP------------VSD-M--NIAS-GCPLFCPLS KLDS-KN-SYIRDDTIFI---KAIVD-LTGL----------------------------- ------------------------------------------------------------ --------------- >O_latipes_ENSORLP00000008989 ------------------------------------------------------------ --MARISWDSL--SSLP----------GIPLSVLSVPMEDKYKCQQCLQVLRKPVQA-Q- ------------------------CGHRFCVHCFRQLT-------SSGP---KPCQACRK EEIYEEPMSI-LNSSE--AFPDNAAGREIASLPARCLNQG--CDWTGSIKEYE------- -------------------------------------------AKH--E-GRCEFEQIQC EA-------CQALVLRKD----KDR----HNDRECEERTLNCKYCKVTFNFKDI-K--AH D------------------------------------------------------EICQK FPLQCKD--CGK--KKIPREKFNDHAK-SCAKS--KSACPFSEVGCK---S-V-VENGKI SEHEHSSTMEHLRLLL--PMVLSMTRTRLDT----------------------------- ---SPSGEWQEDSGLGLYRAPDD-----------GCGAAASVPSVDLDKKVSALEN---- IVCVLNREVERSSLT----LEAFSHQHRLD--------------QEKIENLSNK------ --------------------IRQL-----ERSLTVKDLQLSEAEQMV--R--ELQYCTYD -G---------------IFVWKITDFSHRRQEAVSGRA--PAMFSPAFYSSKYGYKMCLR LYLNGDGTGR-GTHLSLFF--VVMRSKYDALLKWPFSQK---RTIWAASKP----NR--- -EEHIIDAFRPDI---TST---SFQRP------------VSE-M--NIAS-GCPLFCPLA KLAG-KS-PYLRDDTIFI---KAIVD-LSGL----------------------------- ------------------------------------------------------------ --------------- >T_nigroviridis_ENSTNIP00000016461 ----------------------------------------------------MA------ --AQEPSPPSSMESNKP----------GFPKKILGNKLEDKHLCNCCHNILRRPFQA-Q- ------------------------CGHRFCSYCFTRTV-------SNGP---QKCSACIK EDIFEDPTSI-LKQGC--AFPDNAVRREVEHLPAVCINEN--CTWKGTIKEYE------- -------------------------------------------LSH--E-GKCEFMIISC PS-------CKEHIRFNE----QER----HNERECPERTLNCKYCKEPFHFKNI-K--AH D------------------------------------------------------EICPK YPMICEG--CAK--KKIPREKYVDHIK-FCSKF--RTPCRFHVVGCD---M-S-VEKEKI HDHERAFAYEHLNLLL--HYIMGMKASRAG------------------------------ -------------------------E-------KTKVAELGRRCTELEVKANTFEN---- VVCVLNREVERFATT----MEASNRQHKLD--------------QDKIEALSNK------ --------------------VRQL-----ERTVGLKDLTVAEMEGRL--R--EMSATTFD -G---------------VFVWRISDFAKKRQDAIAGRA--PAMFSPAFYTSKYGYKMCLR IYLNGDGTGR-GSHLSLFF--VVMRGQSDALLKWPFNQK---VTLMLLDQS----NR--- --EHIIDAFRPDV---TSS---SFQRP------------VSE-M--NIAS-GCPLFCPLS KLDG-KN-SYIRDDTIFI---KAIVD-LTGL----------------------------- ------------------------------------------------------------ --------------- >E_caballus_ENSECAP00000011150 ----------------------------------------------------MA------ --AASVTPPGSLDLLQP----------GFSKTLLGTKLEDKYLCSACKNVLRRPFQA-Q- ------------------------CGHRYCSYCLTSIL-------SSGP---QNCAACVH EGIYEEGISI-LESSS--AFPDNAARREVESLPAVCPSDG--CTWKGTLKEYE------- -------------------------------------------SCH--E-GHCPFMLTEC PA-------CKGLVRLGE----KEH----HLEHECPERSLSCRHCRAPCCWADM-K--AH H------------------------------------------------------DVCPK FPLTCDG--CGK--KKISREKFQDHVR-TCGKC--RVPCRFHAVGCP---E-M-VESEKQ QEHEAKWLQEHLAMLLDSSSFLGQSQVGNPG----------------------------- ------------------------AE-------VSKAAELLQRCEALERKTATFEN---- IVCVLNREVERVAMT----AEACGRQHRLD--------------QDRIEALSNK------ --------------------VQQL-----ERSIGLKDLAMADLEQKV--H--EMEASTFD -G---------------VFIWKISDFTRKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLR IYLNGDGTGR-GTHVSLFF--VVMKGPNDALLRWPFNQK---VTLMLLDQN----NR--- --EHVIDAFRPDV---TSS---SFQRP------------VSD-M--NIAS-GCPLFCPVS KMEA-KN-SYVRDDAIFI---KAIVD-LTGL----------------------------- ------------------------------------------------------------ --------------- >T_guttata_ENSTGUP00000002510 ----------------------------------------------------MA------ --AANSSPPGSLDLNQP----------GFAKEILGTKLEVKYLCSDCKNILRRPFQA-Q- ------------------------CGHRYCSYCLKKII-------SAGP---QKCASCIQ EGIYEEGISI-LETSS--AFPDNAARREVESLPAVCINSG--CNWKGTIKEYE------- -------------------------------------------VQA--K-ARLGTSASFF PL-------C-----LGK----AQRVVCAHVGESCQIPGLYCQLEKFP-NVVHM-V--LH C------------------------------------------------------EETPH CECSWRN--CEGIWKKHPGAAFRDHVK-TCGRS--KVPCRFEAVGCA---E-V-VENEKL PEHERKCLAEHLYMLM--SSVLSLKTGAGDL----------------------------- -----------------------------------KPLPLLGRCEALERKTVTFEN---- IVCVLNREVERVSLT----AEAYSRQHRLD--------------QEKIETLSNK------ --------------------VRQL-----ERSIGLKDLAMAEMEEKI--R--NMEASTYD -G---------------VFIWKITEFARKRQEAITGRS--PAIFSPAFYTSKYGYKMCLR VYLNGDGTGR-GTHLSLFF--VVMKGPNDALLRWPFNQK---VTLMLLDQN----NR--- --EHIIDAFRPDV---TSS---SFQRP------------VTE-M--NIAS-GCPLFCPVS VMEA-KN-SYVRDDAIFI---KAIVD-LTGL----------------------------- ------------------------------------------------------------ --------------- >G_aculeatus_ENSGACP00000022084 ------------------------------------------------------------ --MARISLDCP--VSLP----------GIPLSVLSVPMENKYKCQQCLLVLRKPVQA-Q- ------------------------CGHRFCVHCFRQLT-------SYGP---KPCDACRQ EEIYEEPISI-LNSNE--AFPDNAAGREIASLPAKCLNQG--CDWTGSIKEYE------- -------------------------------------------AQH--E-GRCELERMQC EA-------CKMSVLCTD----KDR----HNERECEERTLNCKYCKMTFNFKEI-K--AH D------------------------------------------------------EICLK FPLQCKD--CGK--KKIPREKFNDHSK-SCAKS--KSSCPFNDVGCK---Y-M-MENGKL GDHEHSSAVEHLRLLL--PLVLS-SVSLAGG----------------------------- ---DAAGELQEDSGLGLYRAPEEGVA-------TGAGAAASALSLDMEKKVNALEN---- IVCVLNREVGRNSVT----LEAFSHQHRLD--------------QEKIENLSNK------ --------------------LLQL-----ERTVSMKDLQLSATDQLL--K--ELQFCTYD -G---------------IFVWKISDFSRRRQDAVAGRT--PAMFSPAFYSSKYGYKMCLR LYLNGDGTGR-GTHLSLFF--VVMRGKCDALLKWPFSQK---VTLMLLDQN----NR--- --EHIIDAFRPDV---TST---SFQRP------------ISE-M--NIAS-GCPLFCPLA KLAG-KS-PYLRDDTIFI---KAIVD-LTGL----------------------------- ------------------------------------------------------------ --------------- >P_pygmaeus_ENSPPYP00000022191 ----------------------------------------------------MA------ --AASVTPPGSLELLQP----------GFSKTLLGTKLEAKYLCSACRNVLRRPFQA-Q- ------------------------CGHRYCSFCLASIL-------SSGP---QNCAACVH EGIYEEGISI-LESSS--AFPDNAARREVESLPAVCPSDG--CTWKGTLKEYE------- -------------------------------------------SCH--E-GRCPLMLTEC PA-------CKGLVRLGE----KER----HLEHECPERSLSCRHCRAPCCGADV-K--AH H------------------------------------------------------EVCPK FPLTCDG--CGK--KKIPREKFQDHVK-TCGKC--RVPCRFHAIGCL---E-T-VEGEKQ QEHEAQWLREHLAMLL--SSVLEAKPLSGDQ----------------------------- ---------------------------------SHAGSELLQRCESLENKTATFEN---- IVCVLNREVERVAMT----AEACSRQHRLD--------------QDKIEALSSK------ --------------------VQQL-----ERSIGLKDLAMADLEQKV--L--EMEASTYD -G---------------VFIWKISDFARKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLR IYLNGDGTGR-GTHLSLFF--VVMKGPNDALLRWPFNQK---VTLMLLDQN----NR--- --EHVIDAFRPDV---TSS---SFQRP------------VND-M--NIAS-GCPLFCPVS KMEA-KN-SYVRDDAIFI---KAIVD-LTGL----------------------------- ------------------------------------------------------------ --------------- >M_mulatta_ENSMMUP00000015132 ----------------------------------------------------MA------ --AASVTPPGSLELLQP----------GFSKTLLGTKLEAKYLCSACGNVLRRPFQA-Q- ------------------------CGHRYCSFCLASIL-------SSGP---QNCAACVH EGIYEEGISI-LESSS--AFPDNAARREVESLPAVCPIDG--CTWKGTLKEYEVKMPVCG TVTEPAVGSRPRSPSGRDLVLHVLTGAEACLMSVEEETELLLRSCH--E-GRCPLMLTEC PA-------CKGLVRLGE----KER----HLEHECPERSLSCRHCRAPCCGADG-K--AH H------------------------------------------------------EVCPK FPLTCDG--CGK--KKIPREKFQDHVK-TCGKC--RIPCRFHAIGCL---E-T-VEGEKQ QEHEAQWLREHLAMLL--SSVLEAKPLLGDQ----------------------------- ---------------------------------SHAGSELLQRCENLEKKTATFEN---- IVCVLNREVERVAMT----AEACSRQHRLD--------------QDKIEALSNK------ --------------------VQQL-----ERSIGLKDLAMADLEQKV--L--EMEASTYD -G---------------VFIWKISDFARKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLR IYLNGDGTGR-GTHLSLFF--VVMKGPNDALLRWPFNQK---VTLMLLDQN----NR--- --EHVIDAFRPDV---TSS---SFQRP------------VND-M--NIAS-GCPLFCPVS KMEA-KN-SYVRDDAIFI---KAIVD-LTGL----------------------------- ------------------------------------------------------------ --------------- >P_troglodytes_ENSPTRP00000036949 ----------------------------------------------------MA------ --AASVTPPGSLELLQP----------GFSKTLLGTKLEAKYLCSACRNVLRRPFQA-Q- ------------------------CGHRYCSFCLASIL-------SSGP---QNCAACVH EGIYEEGISI-LESSS--AFPDNAARREVESLPAVCPSDG--CTWKGTLKEYE------- -------------------------------------------SCH--E-GRCPLMLTEC PA-------CKGLVRLGE----KER----HLEHECPERSLSCRHCRAPCCGADV-K--AH H------------------------------------------------------EVCPK FPLTCDG--CGK--KKIPREKFQDHVK-TCGKC--RVPCRFHAIGCL---E-T-VEGEKQ QEHEAQWLREHLAMLL--SSVLEAKPLSGDQ----------------------------- ---------------------------------SHAGSELLQRCESLEKKTATFEN---- IVCVLNREVERVAMT----AEACSRQHRLD--------------QDKIEALSSK------ --------------------VQQL-----ERSIGLKDLAMADLEQKV--L--EMEASTYD -G---------------VFIWKISDFARKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLR IYLNGDGTGR-GTHLSLFF--VVMKGPNDALLRWPFNQK---VTLMLLDQN----NR--- --EHVIDAFRPDV---TSS---SFQRP------------VND-M--NIAS-GCPLFCPVS KMEA-KN-SYVRDDAIFI---KAIVD-LTGL----------------------------- ------------------------------------------------------------ --------------- >M_musculus_ENSMUSP00000109872 ----------------------------------------------------MA------ --AASVTSPGSLELLQP----------GFSKTLLGTRLEAKYLCSACKNILRRPFQA-Q- ------------------------CGHRYCSFCLTSILRCASILSSSGP---QNCAACVY EGLYEEGISI-LESSS--AFPDNAARREVESLPAVCPNDG--CTWKGTLKEYE------- -------------------------------------------SCH--E-GLCPFLLTEC PA-------CKGLVRLSE----KEH----HTEQECPKRSLSCQHCRAPCSHVDL-E--VH Y------------------------------------------------------EVCPK FPLTCDG--CGK--KKIPRETFQDHVR-ACSKC--RVLCRFHTVGCS---E-M-VETENL QDHELQRLREHLALLL--SSFLEAQASPGTL----------------------------- ---------------------------------NQVGPELLQRCQILEQKIATFEN---- IVCVLNREVERVAVT----AEACSRQHRLD--------------QDKIEALSNK------ --------------------VQQL-----ERSIGLKDLAMADLEQKV--S--ELEVSTYD -G---------------VFIWKISDFTRKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLR VYLNGDGTGR-GTHLSLFF--VVMKGPNDALLQWPFNQK---VTLMLLDHN----NR--- --EHVIDAFRPDV---TSS---SFQRP------------VSD-M--NIAS-GCPLFCPVS KMEA-KN-SYVRDDAIFI---KAIVD-LTGL----------------------------- ------------------------------------------------------------ --------------- >H_sapiens_ENSP00000247668 ----------------------------------------------------MA------ --AASVTPPGSLELLQP----------GFSKTLLGTKLEAKYLCSACRNVLRRPFQA-Q- ------------------------CGHRYCSFCLASIL-------SSGP---QNCAACVH EGIYEEGISI-LESSS--AFPDNAARREVESLPAVCPSDG--CTWKGTLKEYE------- -------------------------------------------SCH--E-GRCPLMLTEC PA-------CKGLVRLGE----KER----HLEHECPERSLSCRHCRAPCCGADV-K--AH H------------------------------------------------------EVCPK FPLTCDG--CGK--KKIPREKFQDHVK-TCGKC--RVPCRFHAIGCL---E-T-VEGEKQ QEHEVQWLREHLAMLL--SSVLEAKPLLGDQ----------------------------- ---------------------------------SHAGSELLQRCESLEKKTATFEN---- IVCVLNREVERVAMT----AEACSRQHRLD--------------QDKIEALSSK------ --------------------VQQL-----ERSIGLKDLAMADLEQKV--L--EMEASTYD -G---------------VFIWKISDFARKRQEAVAGRI--PAIFSPAFYTSRYGYKMCLR IYLNGDGTGR-GTHLSLFF--VVMKGPNDALLRWPFNQK---VTLMLLDQN----NR--- --EHVIDAFRPDV---TSS---SFQRP------------VND-M--NIAS-GCPLFCPVS KMEA-KN-SYVRDDAIFI---KAIVD-LTGL----------------------------- ------------------------------------------------------------ --------------- >G_aculeatus_ENSGACP00000006974 ----------------------------------------------------MA------ --AQEQSPPSSLEGNKP----------GFPKKILANSLEDKHLCNSCQKVLRRPLQA-Q- ------------------------CGHRFCSFCFNKIV-------SSGP---QKCSACIK EDLFEDPTSI-LKQGG--AFPDNAARREVEALAAVCPNEE--CTWTGTIKEFE------- -------------------------------------------ASH--E-DNCDFMIIMC PS-------CKELMRANE----QER----HNERECPERTLNCRYCKEPFLLKNI-K--AH D------------------------------------------------------EICPK YPMICEG--CAK--KKIPREKYVDHIK-FCSKC--KAPCRFHVVGCDASVM-E-VENEKL HDHERQCSYEHLNLLL--HFIMGIK----------------------------------- --------------------LQLQSE-------KAKVAELSRRCQELELKVGTFEN---- IACVLNREMERSCST----MEAYNRQHRLD--------------QDKIEILNNK------ --------------------VRQL-----ERTVSLRDLSIVEMEGKM--R--DMSAATYD -G---------------IFVWKISDFTKKRQDAVAGRA--PAMFSPAFYTSKYGYKMCLR IYLNGDGTGR-GTHLSLFF--VVMRGHSDALLKWPFNQK---VTLMLLDQN----SR--- --EHIIDAFRPDV---SSS---SFQRP------------VSD-M--NIAS-GCPLFCPLP KLDS-KN-SYIRDDTIFI---KAIVD-LTGL----------------------------- ------------------------------------------------------------ --------------- >T_nigroviridis_ENSTNIP00000013509 ----------------------------------------------------MA------ --SQEPSPPSSLEGNKP----------GFPRKILANNLESKHLCKSCQKVLRRPLQA-Q- ------------------------CGHRFCCFCFRKIV-------SAGP---QTCRACIS EDLFEEPASI-LKSGG--AFPDNAARREVEALAAVCPNEG--CTWTGTIKEFE------- -------------------------------------------ARH--E-DSCDFMIILC PS-------CKELMRANE----QER----HNERECPERTLNCKYCKEAFQLKSI-K--AH D------------------------------------------------------EICPK YPMMCEG--CSR--RKIPREKYVDHIK-YCSKF--KSPCRFHVVGCN---I-K-VEKEKI HEHERQCSYEHLNLLL--HFIMGIKSS--------------------------------- -----------------------RAK-------KTKVAELSRRCQELEVKVSTLEN---- IACVLNREVERSCTT----MDAYNRQHRLD--------------QDKIEILNNK------ --------------------VRQL-----ERTVSLRDLSIVEMDEKM--R--ELSAATYD -G---------------VFVWKIADFTKKRQDAVAGRA--PAMFSPAFYTSKYGYKMC-R IYLNGDGTGR-GSHLSLFF--VVMRGHSDALLKWPFNQK---VTLMLLDQN----NR--- --EHIIDAFRPDV---SSS---SFQRP------------VSD-M--NIAS-GCPLFCPLS KLDC-KN-SYIRDDTIFI---KVIVD-LSGL----------------------------- ------------------------------------------------------------ --------------- >B_taurus_ENSBTAP00000013869 ----------------------------------------------------MA------ --AASVTPPGSLDLLQP----------GFSKTLLGTKLEDKYLCSACKNVLRRPFQA-Q- ------------------------CGHRYCSFCLSSIL-------SSGP---QSCAACVH EGIYEEGVSI-LESSS--AFPDNAARREVESLPAVCPSEG--CSWKGTLKDYE------- -------------------------------------------SCH--E-GQCPFMLTEC PA-------CKGLVRLGE----KEH----HLEHQCPERSLSCRHCRAPCSPADM-K--AH H------------------------------------------------------QICPK FPLTCDG--CGK--KKIAREKFQDHVR-ACGRC--RVPCRFHAVGCP---E-M-VESEQQ PEHEAQRLQEHLALLL--GVLLEAGRPPGDS----------------------------- ------------------------RL-------LLRVAELLQRCEALERKTATFEN---- IVCVLNREVERVAVT----AEACGRQHRLD--------------QDRIEALSNK------ --------------------VQQL-----ERSIGLKDLAMADLEQKV--L--EMEASTFD -G---------------VFIWKISDFSRKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLR AYLNGDGTGR-GTHLSLFF--VLMRGPHDALLRWPFNQK---VTLMLLDQN----NR--- --EHVIDAFRPDV---TSS---SFQRP------------VGD-M--NIAS-GCPLFCPVS KMEA-KN-SYVRDDAIFI---KAIVD-LTGL----------------------------- ------------------------------------------------------------ --------------- >X_tropicalis_ENSXETP00000042386 -------A---------------------------------------------------- ----NLSSVPVENEFVF----------GYPTTICDVAPGEKYLCCSCNSVSLNRNHD-L- ------------------------------------------------------CPKCKA EDPT--------------TLSDDSLLKE-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------ERFAFNYTNAQLI-VCPEH-------------S---F-S-GSREKI KEHYRTSAAAHLSLVC--PLILRIKDNLTNT---EDSTDGPGQKNPF------------S LQAEDFKAGNGDLELDCGHAVGQPSD------------EVANRLSLLETRLQVFEN---- IISVLSKEIDSSQSQ----LAAIKEQKAEE--------------ERKVKALEHK------ --------------------VENL-----RCTLAMKDIVLNELEMRS--A--CLEQTSYD -G---------------VFLWKISDLTNKSHDAVTGRA--ISLYSPVSPSFK-GKSIPSL FPVSLSFKGK-STPHCFLFHPVSRRSQSPSLFPVSLSFK---VTFVLVDHN----NR--- --DSVFDAFRPDV---TSA---SFQRP------------IND-M--NVAS-GCPLFCPIA KLNSPKH-AYIRENTLYI---RCIID-TNS------------------------------ ------------------------------------------------------------ --------------- >X_tropicalis_ENSXETP00000008559 ------------------------------------------------------------ AAAVSGSPQGSLDLNQP----------GFKKEILGTKLEVKYLCSDCKNLLRRPLQA-Q- ------------------------CGHRYCSHCLNKII-------STGP---QKCSACIQ EGIWHQTVCI-VSDWG--GQPGNV--RGVGGGSSVILGGGMYCVLNPTHQSGR------- -------------------------------------------YCY--S-LGTCTALTHC VL-------CPGYPWNYS----GDL----HSERECPERKLNCRYCKLSFYFPDI-K--AH D------------------------------------------------------EICPK FPMTCEG--CGR--KKIPREKFPDHVK-ICGRC--KVPCRYAAVGCT---E-M-VENDKC LEHENKSLAEHLAKGS--PAPPANAPPNNSA----------------------------- -----------------------------------KVAEMLLKFDTLDKKNTTFEN---- IVSVLNREVERSSHA----AEELARQLRAA--------------QEKVEALTTK------ --------------------VRQL-----ERTLGQKELIVAELETRM--Q--ESELSTYD -G---------------VFIWKISEFGKKRQDAINGRC--PAMFSPPFYTNKYGYKMCLR IYLNGDGTGR-NTHLSLFF--VVMKGNNDALLRWPFNQK---VTLMLLDQN----NR--- --EHVIDAFRPDV---SSS---SFQRP------------ISE-M--NIAS-GCPLFCQVS KLEG-KN-SYVRDDTIFV---KVIVD-LTGL----------------------------- ------------------------------------------------------------ --------------- >G_aculeatus_ENSGACP00000020860 ----------------------------------------------------MA------ --TQEPSPPSSMESNKP----------GFPKKILGNQLEDKHLCNCCHNILRRPFQA-Q- ------------------------CGHRFCSYCFNRTV-------SNGP---QKCSACIK EDLFEDPTSI-LKPGC--AFPDNAVRREVENLSAVCIHEH--CSWKGSIKDYE------- -------------------------------------------LTH--E-GKCEFMIIPC PS-------CKERIRFNE----QER----HNERECPERTLNCKYCKEPFHFKNI-K--AH D------------------------------------------------------EICPK YPMICEG--CAK--KKIPREKYVDHIK-FCSKF--RTPCRFHVVGCD---M-S-VEKEKI HDHERAFAYEHLNLLL--HYIMGMKVSMEGL---QPQGLELAGHKLLELQQAL-RELE-A RVSQLSTTSSGP----------------------------PVQCTELEVKAGTFEN---- VVCVLNREVERFATA----MEASNRQHKLD--------------QDKIEALSNK------ --------------------VRQL-----ERTVGLKDLTVAEMEGRL--R--EMSATTFD -G---------------VFVWRISDFAKKRQDAIAGRA--PAMFSPAFYTSKYGYKMCLR IYLNGDGTGR-GSHLSLFF--VVMRGLSDALLKWPFNQK---VTLMLLDQS----NR--- --EHIIDAFRPDV---TSS---SFQRP------------LER---------PCSL----- --------CF-------------------------------------------------- ------------------------------------------------------------ --------------- >G_gorilla_ENSGGOP00000004192 -------MESSK----------------KM---DSPGALQTNPPLKLHT----------- ----DRSAGTPVFVPEQ----------GGYKEKXXXXXXXXXXXXXXXXXXXXXXXX-X- ------------------------XXXXXXXXXXXXXX-------X-XX--XXXXXXXXX S----------IVKDK--VFKDNCCKREILALQIYCRNESRGCAEQLTLGHLL------- --------------------------------------------XX--XXXXXXXXXXXX XXX-----XXXXXXXXXX----XXX----XXXXXXXXXXXXXXXXXXXXXXXXX-X--KH E-----------------------------------------------------DTDCPC VVVSCPH--KCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F-Q-GTNQQI KAHEASSAVQHVNLLK--EWSNSLEKKVSLL---QNESVEKNKSIQSLHNQICSFEIE-I ERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- N---WE---EADSMK----SSVESLQNRVT-ELESVDKSAGQV-ARNTGLLESQ------ --------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCAR VYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----SS--- -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQT VLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- ------------------------------------------------------------ --------------- >H_sapiens_ENSP00000376500 -------MESSK----------------KM---DSPGALQTNPPLKLHT----------- ----DRSAGTPVFVPEQ----------GGYKEKFVKTVEDKYKCEKCHLVLCSPKQT-E- ------------------------CGHRFCESCMAALL-------S-SS--SPKCTACQE S----------IVKDK--VFKDNCCKREILALQIYCRNESRGCAEQLMLGHLL------- --------------------------------------------VH--LKNDCHFEELPC VRP-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMIAL-Q--KH E-----------------------------------------------------DTDCPC VVVSCPH--KCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F-Q-GTNQQI KAHEASSAVQHVNLLK--EWSNSLEKKVSLL---QNESVEKNKSIQSLHNQICSFEIE-I ERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- N---WE---EADSMK----SSVESLQNRVT-ELESVDKSAGQV-ARNTGLLESQ------ --------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCAR VYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----SS--- -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQT VLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- ------------------------------------------------------------ --------------- >P_troglodytes_ENSPTRP00000011503 -------MESSK----------------KM---DSPGALQTNPPLKLHT----------- ----DRSAGTPVFVPEQ----------GGYKEKFVKTVEDKYKCEKCHLVLCSPKQT-E- ------------------------CGHRFCESCMAALL-------S-SS--SPKCTACQE S----------IVKDK--VFKDNCCKREILALQIYCRNESRGCAEQLTLGHLL------- --------------------------------------------VH--LKNDCHFEELPC VRP-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMIAL-Q--KH E-----------------------------------------------------DTDCPC VVVSCPH--KCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F-Q-GTNQQI KAHEASSAVQHVNLLK--EWSNSLEKKVSLL---QNESVEKNKSIQSLHNQICSFEIE-I ERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- N---WE---EADSMK----SSVESLQNRVT-ELESVDKSAGQV-ARNTGLLESQ------ --------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCAR VYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----SS--- -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQT VLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- ------------------------------------------------------------ --------------- >P_pygmaeus_ENSPPYP00000007003 -------MESSK----------------KM---DSPGALQTNPPLKLHT----------- ----DRSAGTPVFVPEQ----------GGYKEKFVKTVEDKYKCEKCRLVLCSPKQT-E- ------------------------CGHRFCESCMAALL-------S-SS--SPKCTACQE S----------IVKDK--VFKDNCCKREILALQIYCRNESRGCAEQLTLGHLL------- --------------------------------------------VH--LKNDCHFEELPC VRP-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMIAL-Q--KH E-----------------------------------------------------DTDCPC VVVSCPH--KCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F-Q-GTNQQI KAHEASSAVQHVNLLK--EWSNSLEKKVSLL---QNESVEKNKSIQSLHNQICSFEIE-I ERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- N---WE---EADSMK----SSVESLQNRVT-ELESVDKSAGQV-ARNTGLLESQ------ --------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCAR VYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----SS--- -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQT VLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- ------------------------------------------------------------ --------------- >G_gallus_ENSGALP00000036699 ---------------------------------------------RANP----------- ----DRSPSASIYVPEQ----------GGYKEKFVNAVEDKYKCEKCHFILCNPKQT-E- ------------------------CGHRFCETCMNALL-------S-TP--SPKCTACQE S----------IVKDK--VFKDNCCRRELLALQIYCRNENKGCKEQLSLGQLL------- --------------------------------------------MH--LKTDCQFEELPC PRA-----DCKEKILRKD----LPD----HVEKTCKYRETTCKYCKSQVPMIML-Q--KH E-----------------------------------------------------DTDCPC VMVSCPH--KCSV-KTLMRSELNAHLS-ECINA--PSTCSFKRYGCT---F-Q-GTNQQI KAHEASSAVQHVNLLK--EWSNALENKVALL---QNESLEKNKSIQTLHNQICSFEIE-I ERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- N---WE---EADSMK----SSVESLQNRVT-ELESVDKTAGQG-ARNTSMLETQ------ --------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCAR VYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----PS--- -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQT VLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- ------------------------------------------------------------ --------------- >R_norvegicus_ENSRNOP00000010906 -------MEPSK----------------KM---GAAGAAQPNPPLKLQP----------- ----DRG-AASVLVPEQ----------GGYKEKFAKTVEDKYKCEKCRLVLCNPKQT-E- ------------------------CGHRFCESCMAALL-------S-SS--SPKCTACQE S----------IIKDK--VFKDNCCKREILALQIYCRNEGRGCVEQLTLGHLL------- --------------------------------------------VH--LKNECQFEELPC LRA-----DCKEKVLRRD----LRD----HVEKACKYREATCAHCKSQVPMITL-Q--KH E-----------------------------------------------------DTDCPC VVVSCPH--KCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F-Q-GTNQQI KAHEASSAVQHVNLLK--EWSNSLEKKVSLL---QNESVEKNKSIQSLHNQICSFEIE-I ERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- N---WE---EADSMK----SSVESLQNRVT-ELESVDKSAGQA-ARNTGLLESQ------ --------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCAR VYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----SS--- -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQT VLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- ------------------------------------------------------------ --------------- >T_guttata_ENSTGUP00000013203 ---------------------------------------------RANP----------- ----DRSPSASIYVPEQ----------GGYKEKFVNAVEDKYKCEKCHLILCNPKQT-E- ------------------------CGHRFCETCMNALL-------R-SS--SPKCTACQE S----------IVKDK--VFKDNCCRRELLALQIYCRNENKGCKEQLSLGQLL------- --------------------------------------------MH--LRTDCQFEELPC PRA-----DCKEKILRKD----LPD----HVEKTCKYRETTCKYCKSQVPMIML-Q--KH E-----------------------------------------------------DTECPC VMVSCPH--KCSV-KTLMRSELNAHLS-ECINA--PSTCSFKRYGCT---F-Q-GTNQQI KAHEASSAVQHVNLLK--EWSNALENKVALL---QNESLEKNKSIQTLHNQICSFEIE-I ERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- N---WE---EADSMK----SSVESLQNRVT-ELESVDKTAGQG-ARNTSLLETQ------ --------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCAR VYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----PS--- -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQT VLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- ------------------------------------------------------------ --------------- >O_anatinus_ENSOANP00000023053 -------MDSSK----------------KM---DPS-LVQQNVPPKGNP----------- ----DRGPGASIYVPEQ----------GGYKERFVKTVEDKYKCEKCHLILCNPKQT-E- ------------------------CGHRFCETCMNMLL-------S-SS--SPKCSACQE N----------VIKDK--VFKDNCCKREILALQIYCRNENRGCTEQLTLGHLL------- --------------------------------------------VH--LKSDCQFEELSC PRA-----DCKEKVLRKD----LPD----HIEKSCKYREATCKYCTSQVPMITL-Q--KH E-----------------------------------------------------DTECPC VVVSCPH--KCSV-QTLLRSELNAHLS-ECINA--PSTCSFKRYGCT---F-Q-GTNQQI KAHEASSAVQHVNLLK--EWSNSLEKKVSLL---QNESVEKNKSIQSLHNQICSFEIE-I ERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- N---WE---EADSMK----SSVESLQNRVT-ELESVDKNAGQA-ARNTGMLETQ------ --------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCAR VYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----SS--- -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQT VLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- ------------------------------------------------------------ --------------- >B_taurus_ENSBTAP00000017918 -------MEPSK----------------KL---DAAGALPANPPLKLHP----------- ----ERGAGPAVLVPEQ----------GGYKERFVKAVEDKYKCEKCRLVLCSPKQT-E- ------------------------CGHRFCETCMGALL-------S-SS--SPKCTACQE V----------IIKDK--VFKDNCCKREILALQIFCRNEGRGCTEQLALGHLL------- --------------------------------------------VH--LKNDCQFEELPC VRA-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMVTL-Q--KH E-----------------------------------------------------DTECPC VAVSCPH--KCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F-Q-GTNQQI KAHEASSAVQHVNLLK--EWSNSLEKKVSLL---QNESVEKNKSIQSLHNQICSFEIE-I ERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- N---WE---EADSMK----SSVESLQNRVT-ELESVDKSAGQA-ARNTGLLESQ------ --------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCAR VYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----SS--- -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQT VLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- ------------------------------------------------------------ --------------- >C_familiaris_ENSCAFP00000026713 -------MESSK----------------KM---DSPGTLQTNPPLKLHP----------- ----DRSAGTSIFVPEQ----------GGYKERFVKTVEDKYKCEKCRLVLCNPKQT-E- ------------------------CGHRFCETCMAAVL-------S-SS--SPKCTACQE S----------IIKDK--VFKDNCCKREILALQIYCRNEGGGCTEQLTLGHLL------- --------------------------------------------VH--LKNDCQFEELSC VRA-----DCKEKVLRRD----LRD----HVEKACKYREATCPHCKSQVPMITL-Q--KH E-----------------------------------------------------DTECPC VVVSCPH--KCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F-Q-GTNQQI KAHEASSAVQHVNLLK--EWSNSLEKKVSLL---QNESVEKNKSIQSLHNQICSFEIE-I ERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- N---WE---EADSMK----SSVESLQNRVT-ELESVDKSAGQA-ARNTGLLESQ------ --------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCAR VYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----SS--- -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQT VLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- ------------------------------------------------------------ --------------- >E_caballus_ENSECAP00000011833 -------MESSK----------------KM---DSPGALQTNPPLKLHP----------- ----DRSTSTAVFVPEQ----------GGYKERFVKTVEDKYKCEKCRLVLCNPKQT-E- ------------------------CGHRFCETCMAALL-------S-SS--SPKCTACQE G----------IIKDK--VFKDNCCKREILALQIYCRNESRGCVEQLTLGHLL------- --------------------------------------------VH--LKNDCQFEELAC VRP-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMITL-Q--KH E-----------------------------------------------------DTECPC VVVSCPH--KCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCI---F-Q-GTNQQI KAHEASSAVQHVNLLK--EWSNSLEKKVSLL---QNESVEKNKSIQSLHNQICSFEIE-I ERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- N---WE---EADSMK----SSVESLQNRVT-ELESVDKSAGQA-ARNTGLLESQ------ --------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCAR VYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----SS--- -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQT VLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- ------------------------------------------------------------ --------------- >M_musculus_ENSMUSP00000021706 -------MESSK----------------KM---DAAGTLQPNPPLKLQP----------- ----DRG-AGSVLVPEQ----------GGYKEKFVKTVEDKYKCEKCRLVLCNPKQT-E- ------------------------CGHRFCESCMAALL-------S-SS--SPKCTACQE S----------IIKDK--VFKDNCCKREILALQVYCRNEGRGCAEQLTLGHLL------- --------------------------------------------VH--LKNECQFEELPC LRA-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMIKL-Q--KH E-----------------------------------------------------DTDCPC VVVSCPH--KCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F-Q-GTNQQI KAHEASSAVQHVNLLK--EWSNSLEKKVSLL---QNESVEKNKSIQSLHNQICSFEIE-I ERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- N---WE---EADSMK----SSVESLQNRVT-ELESVDKSAGQA-ARNTGLLESQ------ --------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCAR VYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----SS--- -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQT VLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- ------------------------------------------------------------ --------------- >X_tropicalis_ENSXETP00000027864 -------MDTGK----------------KT---DPSASV-----QKANP----------- ----DRSLATTIYVPEQ----------GGYKERFLKPVEEKYKCEKCRLVLCNPRQT-E- ------------------------CGHRFCETCMNAIL-------S-ST--SPQCMACED N----------ITKDK--VFKDNCCRREVLALQMFCRNETRGCKELITLGNLL------- --------------------------------------------IH--LKSDCQFEELSC PRA-----DCKEKVIRKD----LSD----HIEKTCKYRETPCKFCRNQVPLVEM-Q--KH E-----------------------------------------------------DVDCPS VVISCPH--MCSV-KSLLRSELNAHLL-ECVNA--PSTCSFKRYGCT---F-K-GTNQQI KAHEASSAVQHVNLMK--EWSNYLEAKVSML---QNESSEKNKSIQILHNQMCSFEIE-I ERHKEQLRNNEARIIQLQRVIEGQAD----------------KLKDLDKEIRNLRQ---- T---GD---EADGMK----SNYESLQNRLS-QLEVMAKNA--A-SWNPGVLETQ------ --------------------INRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCAR VYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VSLMLMDQG----PS--- -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQT VLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- ------------------------------------------------------------ --------------- >M_domestica_ENSMODP00000016701 -------MDSSK----------------KM---DPPNPLQTV-QQKANP----------- ----DRGAAVSIYVPEQ----------GGYKEKFVKPVEDKYKCEKCHLILCNPKQT-E- ------------------------CGHRFCETCMHVLL-------S-AP--SPKCTACQE N----------IIKDK--VFKDNCCKREILALQIYCRNESRGCTEQLTLGHLL------- --------------------------------------------VH--LKSECQFEELPC VRA-----DCKEKILRKD----LQD----HVEKSCKYREATCQYCKSQVPMITL-Q--KH E-----------------------------------------------------DTECPC VVVSCPH--KCSV-QTLLRSELNAHLS-ECINA--PSTCSFKRYGCT---F-Q-GTNQQI KTHEASSAVQHVNLLK--EWSNSLEKKVSLL---QNESVEKNKSIQSLHNQICSFEIE-I ERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- N---WE---EADSMK----SSVESLQNRVT-ELESVDKSAGQA-ARNTGLLETQ------ --------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCAR VYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----SS--- -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQT VLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- ------------------------------------------------------------ --------------- >A_carolinensis_ENSACAP00000000193 -------MDTSK----------------KT---DPPVSVETV-QQKANV----------- ----ERSPVPSVYIPEQ----------GGYKEKFVNAVEDKYKCEKCRLILCNPRQT-E- ------------------------CGHRYCETCMNALL-------S-CT--IPKCTACQE T----------IVKEK--IFKDNCCRRELLALQIFCRNENKGCREQLTLGQLL------- --------------------------------------------TH--LRNDCLFEELPC PRV-----DCKEKILRKD----LPD----HAEKTCKYRETTCKYCKSQVPIIMI-Q--KH E-----------------------------------------------------DADCPC VMVTCPH--KCSV-SALLRKELNAHLS-ECINA--PSTCSFKRYGCT---F-Q-GTNQQV KAHETSSAVQHVDLLK--EWSNCLENKVAML---QNESLEKNKSIQTLHNQICSFEIE-I ERQKEMLRSNESKIHHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- N---WE---EADSMK----SSVESLQNRVT-ELESVDKTAGQG-ARNAGLLESQ------ --------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN -G---------------ILIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCAR VYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----PS--- -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQT VLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- ------------------------------------------------------------ --------------- >T_rubripes_ENSTRUP00000013348 -------MSAGR----------------STDGREVQIPLQQAAPSLAMPLSVA------- -PLLTSHCVPAGFLPLH----------GGFRDHFVEALEAKYCCESCRLVLCQPRQT-E- ------------------------CGHRFCQSCINDIL-------S-HP--NPVCPADTE P----------LFKDK--VFRDVCCHREIMALKVYCRSEANGCQEQMRLQQIP------- --------------------------------------------DH--L-NTCPFFEVPC PLG-----KCKERMMRKE----IPE----HLSWKCKYRETSCEFCMTKMPLTEL-Q--KH K-----------------------------------------------------ETVCPA FPVSCPN--HCSL-SSLPRSELSSHQH-ECPKA--QVSCPFHGYGCT---F-K-GLNQVM RQHESSSAAEHLRMMA--KRNSALESKLDDV---KGELLERFKVLPVLSSRVAELESS-N DELREKNRQTEQKLGTMQKLMSSHSE----------------KLLELELELRSLRG---- L---RD---EVENLR----GTLESVRTRLN-ALEQGGRSGSGS-THTLASLEAQ------ --------------------MNRH-----DDMLSVHDIRLADMDLRF--Q--VLETASYN -G---------------TLIWKIRDYKRRKQEAVAAKT--LSLYSQPFYTGYFGYKMCAR IYLNGDGMGK-GTHLSLFF--VVMRGEYDALLPWPFKQK---VTLMLMDQG----PL--- -KKHLGDAFKPDP---NSS---SFRRP------------VVE-M--NIAS-GCPLFVSQS VLETG---SYIKDDTIFI---KVTVD-TSDLPEP-------------------------- ------------------------------------------------------------ --------------- >D_rerio_ENSDARP00000038596 -------MSAGR----------------NV---EQQIPLQQRPPSLAMP----------- -SMAQRPRPEPGFSPLH----------GGFRDHFVTTPEPKYCCETCRLVLCNPRQT-E- ------------------------CGHRFCESCINELL-------S-KP--NPVCPADLL P----------LFEDK--IFRDVCCNREIMALKVYCRSEKNGCKEQMCLQQVM------- --------------------------------------------EH--L-VICPYFEVPC PLG-----KCKEKMMRKD----MPE----HLSRKCKHREVTCEFCSLKMALTEL-Q--KH K-----------------------------------------------------ETVCPA FPVACPN--HCSF-SSILRSELSSHQH-DCPKA--QVTCSFIRYGCS---Y-K-GLNQEM REHESSFASEHLRMMA--VRNTTLEAKVEDV---KSELMERYKVLPSLSSRLAEVERQ-Y EEMREKNRQLEQKLVSMQMLMSSHSE----------------KLLEVEMELRELRP---- LRAMRE---EVETLR----GSVESMRSMVS-SLDSSCVNSASG-SHTLASLEQQ------ --------------------LTRH-----DDLMSVHDVRLAEMDLKL--Q--VLETASFN -G---------------TLIWKIRDYKRRKQEAVVSKT--LSLYSQPFYTGYFGYKMCAR VYLNGDGMGK-GTHLSLFF--VVMRGEYDALLQWPFKQK---VTLMLMDQG----PA--- -RKHLGDAFKPDP---SSS---SFRRP------------TGE-M--NIAS-GCPLFVAQT VLENG---TYIKDDTIFI---KVTVD-TSDLPDP-------------------------- ------------------------------------------------------------ --------------- >T_nigroviridis_ENSTNIP00000005138 -------PAGG------------------------------------------------- ---------PAGFQPLH----------GGFRDHFVEAPEAKYCCESCRLVLCQPRQT-E- ------------------------CGHRFCQSCITQLL-------G-HA--NPVCPADME P----------LFKDK--IFRDVCCHREIMALKVYCRSEANGCQEQMRLQQIP------- --------------------------------------------DH--L-NVCPFFEVPC PLG-----KCKERMMRKE----IPD----HLSWKCKFRESSCEFCMTKMPLTEL-Q--KH K-----------------------------------------------------ETVCPA FPVSCPN--HCSF-SSLPRSELSNHQH-ECPKA--QVSCQFHGYGCT---F-K-GLNQLM RQHESTSAAEHLRMMA--KRNSMLEGKLDDV---KGELLERLKHLPVVSSRVSELENA-S DELREKNRQMEQKLATMQKLMSSHSE----------------KLLEVELELRALRG---- L---RD---EVENLR----GSLEGFRTRLS-ALEQGGRGGSGS-THTLASLEAQ------ --------------------MNRH-----DDMLSVHDIRLADMDLRF--Q--VLETASYN -G---------------TLIWKIRDYKRRKQEAVAAKT--LSLYSQPFYTGYFGYKMCAR IYLNGDGMGK-GTHLSLFF--VVMRGEYDALLPWPFKQK---VTLMLMDQG----PL--- -KKHLGDAFKPDP---NSS---SFRRP------------VVE-M--NIAS-GCPLFVSQS VLETG---SYIKDDTIFI---KVTVD-TSDLPEP-------------------------- ------------------------------------------------------------ --------------- >G_aculeatus_ENSGACP00000005703 -------------------------------GGRCRFPLQQVAPSLTPALSVASPVHRQV NPWPPSDTTPQRFLPLH----------KGFRDHFALTPEAKYCCETCSLVLCQPRQT-E- ------------------------CGHRFCQSCINDIL-------S-HP--NPVCPADME P----------LFKDK--IFRDVCCHREIMALKVYCRSEANGCQEQMSLQQIP------- --------------------------------------------DH--L-NVCPFFEVPC PLG-----KCKERMMRKE----IPD----HLSWKCKHRETSCEFCMTKMPLTDL-Q--KH K-----------------------------------------------------ETVCPA FPVSCPN--HCSV-SSLPRSELSSHQN-DCPKA--QVCCQFQRYGCT---F-Q-GLNQDM RQHESTSAGEHLRMIA--NKNSVLENKVEDI---KGELLERYKVLPALSSRLSELENQ-S DELREKNRQVEQKLATMQKLMSSHSE----------------KLLEVELELRSLRV---- L---RD---EVENLR----GTLENVRTRLN-TLEQGGRSGTGSTTHTLATLENQ------ --------------------LKRH-----DEMLSVHEIRLADMDLRF--Q--VLETASYN -G---------------TLIWKIRDYKRRKQEAVGAKT--LSLYSQPFYTGYFGYKMCAR VYLNGDGMGK-GTHLSLFF--VVMRGEYDALLPWPFKQK---VTLMLMDQG----PL--- -RKHLGDAFKPDP---NSS---SFRRP------------AAE-M--NIAS-GCPLFVSQS VLETG---TYIKDDTIFI---KVTVD-TSDLPDP-------------------------- ------------------------------------------------------------ --------------- >C_intestinalis_ENSCINP00000003143 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------MAPENLSQM------ --------------------VDAF-----ERQLGMYDVRIADMDQRF--Q--VIETTSYS -G---------------VVIWKIRDFSRRKREAVSGRT--LSLYSQPFYTSRYGYKMCAR VYLNGDGMGK-GTHMSLFF--VVMKGEYDALLPWPFRQK---VTLMLLDQG----MD--- -RRHLSDTFRPDP---TSS---SFKKP------------TSD-M--NIAS-GCPLFVAHN VIEDS---SYVKEDTIFL---RIHVD-TSDLENF-------------------------- ------------------------------------------------------------ --------------- >B_taurus_ENSBTAP00000015940 -------MAYFE----------------EQG-GVPCGFT--------------------- ----RQNSGNSISLDFE----------PDAEYQFVERLEERYKCAFCHSVLHNPHQT-G- ------------------------CGHRFCHQCILALR-------ELDT--VPLCPVDKE V----------IKSQE--VFKDNCCKREVLNLYVFCKN-APRCNAKIILGRYQ------- --------------------------------------------DH--L-QHCLFQPVQC SNE-----NCREPVLRKD----LKE----HLSAYCQFREEKCLYCKKDVVVINL-Q--NH E-----------------------------------------------------ENLCPD YPVSCPN--KCL--QTIPRTEVDEHLA-VCPEA--EQDCAFKNYGCA---V-K-DKRGNL QEHERSALRDHMLLVL--EKNFQLEEQISDL---YKSLEQKESKIQQLAEMVKKFEKE-F KQFAQLFGKNGSFLSNMQ-VLASHID----------------KSAWLEVQVRQLLQ---- MANQQQSKFDLKPLV----EAIDTVKQKIT-LLETN--------DQRLVVLEGE------ --------------------TNKH-----DAHINIHKAQLNKNEERF--K--LLESACYN -G---------------KLIWKVTDYKLKKKEALDGHT--VSIFSQPFYTSRCGYRLCAR AYLNGDGSGK-GTHLSLYF--VVMRGEFDSLLQWPFRQR---VTLMLLDQS----GK--- -KNHIMETFKADP---NSS---SFKRP------------DGE-M--NIAS-GCPRFVAHS TLENAKN-TYIKDDTLFL---KVAVD-LTDLEDL-------------------------- ------------------------------------------------------------ --------------- >C_intestinalis_ENSCINP00000001432 -------M---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----YSHKILQRQLQ--EMKNAVE-----L---EMRKRESDRDGNVLRANITKLEQR-L TALQRMTAQQTDRSLALKKEVGDNDA----------------ANKRANTE---LTQ---- K---VE---EIGREI----AQIKEKQNELKRKLESTSSSR--E-QIAPENLSQM------ --------------------VDAF-----ELQLGMYDVRIADMDQRF--Q--VIETTSYS -G---------------FLIWKIRDFSRRKREAVSGRT--LSLYSQPFYTSRYGYKMCAR VYLNGDGMGK-GTHMSLFF--VVMKGEYDALLPWPFRQK---VTLMLLDQG----MD--- -RRHLSDTFRPDP---TSS---SFKKP------------TSD-M--NIAS-GCPLFVAHN VIEDS---SYVKEDTIFL---RIHVD-TSDLENF-------------------------- ------------------------------------------------------------ --------------- >M_mulatta_ENSMMUP00000015419 -------MESSK----------------KM---DSPGPLQTNPPLKLHT----------- ----DRSAGTPIFAPEQ----------GGYKEKFVKTVEDKYKCEKCRLVLCSPKQT-E- ------------------------CGHRFCESCMAALL-------S-SS--SPKCTACQE S----------VVRDK--VFKDNCCKREILALQIYCRNESRGCAEQLTLGHLL------- --------------------------------------------VH--LKNDCHFEELPC VRA-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMIAL-Q--KH E-----------------------------------------------------DTDCPC VVVSCPH--KCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F-Q-GTNQQI KAHEASSAVQHVNLLK--EWSNSLEKKVSLL---QNESVEKNKSIQSLHNQICSFEIE-I ERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- N---WE---EADSMK----SSVESLQNRVT-ELESVDKSAGQV-ARNTGLLESQ------ --------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCAR VYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----SS--- -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQT VLENG---TYIK------------------------------------------------ ------------------------------------------------------------ --------------- >M_mulatta_ENSMMUP00000038268 -------MAYSE----------------EHR-GMPCGFI--------------------- ----RQNSGNSISLDFE----------PNIEYQFVERLEERYKCAFCRSVLHNPHQT-G- ------------------------CGHRFCQHCILSLR-------ELNT--VPICPVDKE V----------IKSQE--VFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQ------- --------------------------------------------DH--L-QQCLFQAVQC SNE-----NCQEPVLRKD----LKE----HLSAYCQFREEKCLYCKKDVVVINL-Q--NH E-----------------------------------------------------ENLCPE YPVFCPN--NCA--KIILKTEVDEHLA-VCPEA--EQDCPFKHYGCA---V-T-DKRRNL QEHEHSALREHMRLVL--EKNVQLEEQISDL---HKSLEQKESKIQQLAETIKKLEKE-F KQFAQLFGKNGSFLPNIQ-VFASHID----------------KSAWLEAQVHQLLQ---- MVNQQQNKFDLRPLM----EAVDTVKQKIT-LLENN--------DQRLAVLEEE------ --------------------TNKH-----DTHINIHKAQLNKNEERF--K--LLEGTCYN -G---------------KLIWKVTDYKMKKREAVDGHT--VSIFSQSFYTGRCGYRLCAR AYLNGDGSGK-GTHLSLYF--VVMRGEFDSLLQWPFRQR---VTLMLLDQS----GK--- -KN-IMETFKPDP---NSS---SFKRP------------DGE-M--NIAS-GCPRFVAHS VLENAKN-AYIKDDTLFL---KVAVD-LTDLEDL-------------------------- ------------------------------------------------------------ --------------- >P_pygmaeus_ENSPPYP00000000253 -------MAYSE----------------EHK-GMPCGFI--------------------- ----RQNSGNSISLDFE----------PNIEYQFVERLEERYKCAFCHSVLHNPHQT-G- ------------------------CGHRFCQHCILSLR-------ELNT--VPICPVDKE V----------IKSQE--VFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQ------- --------------------------------------------DH--L-QQCLFQAVQC SNE-----KCREPVLRKD----LKE----HLSAYCQFREEKCLYCKKDVVVINL-Q--NH E-----------------------------------------------------ENLCPE YPVFCPN--NCA--KIILKTEVDEHLA-VCPEA--EQDCPFKHYGCA---V-T-DKRRNL QEHERSALREHMRLVL--EKNVQLEEQISDL---HKSLEQKESKIQQLAETIKKLEKE-F KQFAQLFGKNGSFLPNIQ-VFASHID----------------KSAWLEAQVHQLLQ---- MVNQQQNKFDLRPLM----EAVDTVKQKIT-LLENN--------DQRLAVLEEE------ --------------------TNKH-----DTHINIHKAQLSKNEERF--K--LLEGTCYN -G---------------KLIWKVTDYKMKKREAVDGHT--VSIFSQSFYTSRCGYRLCAR AYLNGDGSGK-GTHLSLYF--VVMRGEFDSLLQWPFRQR---VTLMLLDQS----GK--- -KN-IMETFKPDP---NSS---SFKRP------------DGE-M--NIAS-GCPRFVAHS VLENAKN-AYLKDDTLFL---KVAVD-LTDLEDL-------------------------- ------------------------------------------------------------ --------------- >P_troglodytes_ENSPTRP00000003288 -------MAYSE----------------EHK-GMPCGFI--------------------- ----RQNSGNSISLDFE----------PNIEYQFVERLEERYKCAFCHSVLHNPHQT-G- ------------------------CGHRFCQHCILSLR-------ELNT--VPICPVDKE V----------IKSQE--VFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQ------- --------------------------------------------DH--L-QQCLFQAVQC SNE-----KCREPVLRKD----LKE----HLSAYCQFREEKCLYCKKDVVVINL-Q--NH E-----------------------------------------------------ENLCPE YPVFCPN--NCA--KIILKTEVDEHLA-VCPEA--EQDCPFKHYGCA---V-T-DKRRNL QEHEHSALREHMRLVL--EKNVQLEEQISDL---HKSLEQKESKIQQLAETIKKLEKE-F KQFAQLFGKNGSFLPNIQ-VFASHID----------------KSAWLEAQVHQLLQ---- MVNQQQNKFDLRPLM----EAVDTVKQKIT-LLENN--------DQRLAVLEEE------ --------------------TNKH-----DTHINIHKAQLSKNEERF--K--LLEGTCYN -G---------------KLIWKVTDYKMKKREAVDGHT--VSIFSQSFYTSRCGYRLCAR AYLNGDGSGR-GTHLSLYF--VVMRGEFDSLLQWPFRQR---VTLMLLDQS----GK--- -KN-IMETFKPDP---NSS---SFKRP------------DGE-M--NIAS-GCPRFVAHS VLENAKN-AYIKDDTLFL---KVAVD-LTDLEDL-------------------------- ------------------------------------------------------------ --------------- >E_caballus_ENSECAP00000005414 -------MAYSE----------------EQG-GVPCGFI--------------------- ----RQNSSNSVSLDFE----------PNTEYRFVEQLEERYKCAFCHSVLHNPHQT-G- ------------------------CGHRFCQHCILSLR-------ELNA--VPLCPVDKE V----------IKSQE--VFKDNCCKREVLNLYVYCKN-APGCNAKIILGRYQ------- --------------------------------------------DH--L-QQCLFQAVQC SNE-----HCQESVLRKN----LKE----HLSAYCQFREEKCLYCKKDVVVINL-Q--NH E-----------------------------------------------------ENMCPE YPVSCPN--KCL--QIIPRTEVDEHLA-VCPEA--EQDCPFKQYGCP---V-K-DKRGNL QEHEHSALRDHMLLVL--EKNLQLEKQISDL---HRSLERKESKIQQLTETVNKFEKE-F KQFAQLFGKNGSFLSNIQ-LLASHLD----------------KSAWLEAQVRQLLQ---- MANQQETKFDLRALM----EAIDTVKQKIT-LLETH--------DQRIVVLEGE------ --------------------TNKH-----DVHINIHKAQLNKNEERF--K--LLEGACYN -G---------------KLIWKVTDYKMKKREALEGHT--VSIFSQPFYTSRCGYRLCAR AYLNGDGSGK-GTHLSLYF--VVMRGEFDSLLQWPFRQR---VTLMLLDQS----GK--- -KNHIMETFKADP---NSS---SFKRP------------DGE-M--NIAS-GCPRFVAHS TLENAKN-TYIKDDTIFL---KVAVD-LTDLEDL-------------------------- ------------------------------------------------------------ --------------- >C_intestinalis_ENSCINP00000027890 -------M---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ L-----------------------------------------------------STENVS -PSLQRS--S-------V---FNSWTS-KSPID--FSISEPSFNFNG---L-S-HPEVGI SDYCKSEHDALRSHLA--EISQTL---------------NNLKNSNDVSPEIRKLEVR-L KAIQRMTAQQTDRSLALKKEVGDNDA----------------ANKRANTD---LTQ---- K---VE---EIAREI----AQIKEKQNELERNIESTSGSR--E-QMAPENLSQM------ --------------------VDAF-----ERQLGMYDVRIADMDQRF--Q--VIETTSYS -G---------------VVIWKIRDFSRRKREAVSGRT--LSLYSQPFYTSRYGYKMCAR VYLNGDGMGK-GTHMSLFF--VVMKGEYDALLPWPFRQK---VTLMLLDQG----MD--- -RRHLSDTFRPDP---TSS---SFKKP------------TSD-M--NIAS-GCPLFVAHN VIEDS---SYVKEDTIFL---RIHVD-TSDLENF-------------------------- ------------------------------------------------------------ --------------- >C_familiaris_ENSCAFP00000017853 -------MAYSE----------------DQG-GVPCGFI--------------------- ----RQNSSNSISLDFE----------PHTEYRFVEPLEERYKCALCHSVLHNPHQT-G- ------------------------CGHRFCQHCILSLR-------ELNA--VPLCPVDKE V----------IKSQE--VFKDNCCKREVLNLYVYCKN-APGCNAKIILGRYQ------- --------------------------------------------QYIWL-QYSTPRAKVR VNRRSIGTSCKHTMCRGS----EGE----LLSHETALPGSSILLGKQEACILSLSQ--NH E-----------------------------------------------------ENLCPE YPVPCPN--KCS--QIIPRTEVDEHLT-VCPEA--EQDCPFKHYGCT---V-K-DKRGSL QEHEHSALRDHMLLVL--EKNLQLEEQISDL---YKSLEQKESKIQQLAETVKKFEKE-F KQFAQLFGKNGSFLSNIQ-VLANHID----------------KSAWLEAQVRQLLQ---- MANQQQNKFDLRPLV----EAIDTVKQKIT-LLETN--------DQRLVVLEGE------ --------------------TNKH-----DAHINIHKAQLNKNEERF--K--LLEGACYN -G---------------KLIWKVTDYKMKKREALDGHT--VSIFSQPFYTSRCGYRLCAR AYLNGDGSGK-GTHLSLYF--VVMRGEFDSLLQWPFRQR---VTLMLLDQS----GK--- -KNHIMETFKADP---SSS---SFKRP------------DGE-M--NIAS-GCPRFVAHS TLENAKN-TYIKDDTVFL---KVAVD-LTDLEDL-------------------------- ------------------------------------------------------------ --------------- >C_intestinalis_ENSCINP00000001022 -------MDTAD------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------S--RH Q-----------------------------------------------------SGENSS FASSQPE--S-------VDQIPQNHLN-ESPYV--LNNEALSLESSL---T-T-GDLNSV KAQCEYSHKILQRQLQ--EMKNAVE-----L---EMRKRESDRDGNVLRANITKLEQR-L TALQRMTAQQTDRSLALKKEVGDNDA----------------ANKRANTD---LTQ---- K---VE---EIAREI----AQIKEKQNELERKIESTSSSR--E-QMAPENLSQM------ --------------------VDAF-----ERQLGMYDVRIADMDQRF--Q--VLETTSYS -G---------------VVIWKIRDFSRRKREAVSGRT--LSLYSQPFYTSRYGYKMCAR VYLNGDGMGK-GTHMSLFF--VVMKGEYDALLPWPFRQK---VTLMLLDQG----MD--- -RRHLSDTFRPDP---TSS---SFKKP------------TSD-M--NIAS-GCPLFVAHN VIEGS---SYVKEDTIFL---RIHVD-TSDLENF-------------------------- ------------------------------------------------------------ --------------- >H_sapiens_ENSP00000336825 -------MAYSE----------------EHK-GMPCGFI--------------------- ----RQNSGNSISLDFE----------PSIEYQFVERLEERYKCAFCHSVLHNPHQT-G- ------------------------CGHRFCQHCILSLR-------ELNT--VPICPVDKE V----------IKSQE--VFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQ------- --------------------------------------------DH--L-QQCLFQPVQC SNE-----KCREPVLRKD----LKE----HLSASCQFRKEKCLYCKKDVVVINL-Q--NH E-----------------------------------------------------ENLCPE YPVFCPN--NCA--KIILKTEVDEHLA-VCPEA--EQDCPFKHYGCA---V-T-DKRRNL QQHEHSALREHMRLVL--EKNVQLEEQISDL---HKSLEQKESKIQQLAETIKKLEKE-F KQFAQLFGKNGSFLPNIQ-VFASHID----------------KSAWLEAQVHQLLQ---- MVNQQQNKFDLRPLM----EAVDTVKQKIT-LLENN--------DQRLAVLEEE------ --------------------TNKH-----DTHINIHKAQLSKNEERF--K--LLEGTCYN -G---------------KLIWKVTDYKMKKREAVDGHT--VSIFSQSFYTSRCGYRLCAR AYLNGDGSGR-GSHLSLYF--VVMRGEFDSLLQWPFRQR---VTLMLLDQS----GK--- -KN-IMETFKPDP---NSS---SFKRP------------DGE-M--NIAS-GCPRFVAHS VLENAKN-AYIKDDTLFL---KVAVD-LTDLEDL-------------------------- ------------------------------------------------------------ --------------- >O_cuniculus_ENSOCUP00000003184 ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------SS--SPKCTACQE S----------IVKDK--VFKDNCCKREILALQICCRNESRGCAEQLALGHLL------- --------------------------------------------VH--LKNDCQFEELAC VRA-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMITL-Q--XX X-----------------------------------------------------XXXXXX XXXXXXX--XXXX-XXXXXXXLSAHLS-ECVNA--PSTCSFKRYGCV---F-Q-GTNQQI KAHEASSAVQHVNLLK--EWSNSLEKKVSLL---QNESVEKNKSIQSLHNQICSFEIE-I ERQKEMLRNNESKILHLQXXXXXXXX----------------XXXXXXXXXXXXXX---- X---XX---XXXXXX----XXXXXXXXXXX-XXXXXXXXXXXX-XXXXXLLESQ------ --------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCAR VYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----SS--- -RRHLGDAFKPDP---NSS---SFRKP------------TGE-M--NIAS-GCPVFVAQT VLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- ------------------------------------------------------------ --------------- >R_norvegicus_ENSRNOP00000058607 ----------------------------------------------------MA------ --AASVTSPGSLELLQP----------GFSKTLLGTRLEAKYLCSACRNILRRPFQA-Q- ------------------------CGHRYCSFCLTSILRSQSAHSSSGP---QNCAACVH EGLYEEGISI-LESSS--AFPDNAARREVESLPAVCPNDG--CTWKGTLKEYE------- -------------------------------------------SCH--E-GLCPFLLTEC PA-------CKGLVRLSE----KKH----HTEQECPKRSLSCQHCRAPCSHADL-E--LH Y------------------------------------------------------EVCPK FPLTCDG--CG---KKISQEKLQDHVR-TCSKC--RVLCRFHAIGCS---E-L-VETEDL QDHELQRLREHLALLL--SSFLESQASQNQV----------------------------- ------------------------------------GPELLQRCQILEQKIATFEN---- IVCVLNREVERVAVT----AEACSRQHRLD--------------QDKIEALSNK------ --------------------VQQL-----ERSIGLKDLAMADLEQKV--S--ELEVSTYD -G---------------VFIWKISDFARKRQEAIAGRT--PAIFSPGAVCVLRMLLMLLN VYLQGRGTGR-QTHLSQLS--VCARAYWAVVLQWLLTEQ---VTLMLLDHN----NR--- --EHVIDAFRPDV---TSS---SFQRP------------VSD-M--NIAS-GCPLFCPVS KIEA-KN-SYVRDDAIFI---KAIVD-LTGL----------------------------- ------------------------------------------------------------ --------------- >M_musculus_ENSMUSP00000082710 -------MAHSE----------------EQA-AVPCAFI--------------------- ----RQNSGNSISLDFE----------PDTEYQFVEQLEERYKCAFCHSVLHNPHQT-G- ------------------------CGHRFCQQCIRSLR-------ELNS--VPICPVDKE V----------IKPQE--VFKDNCCKREVLNLHVYCKN-APGCNARIILGRFQ------- --------------------------------------------DH--L-QHCSFQAVPC PNE-----SCREAMLRKD----VKE----HLSAYCRFREEKCLYCKRDIVVTNL-Q--DH E-----------------------------------------------------ENSCPA YPVSCPN--RCV--QTIPRARVNEHLT-VCPEA--EQDCPFKHYGCT---V-K-GKRGNL LEHERAALQDHMLLVL--EKNYQLEQRVSRI---IEALSRKQTHSQRLPLTAPKKKKE-H PALRPICSVSGTLVSSGK-ALTSHTD----------------KSAWLEAQVRQLLQ---- IVNQQPSRLDLRSLV----DAVDSVKQRIT-QLEAS--------DQRLVLLEGE------ --------------------TSKH-----DAHINIHKAQLNKNEERF--K--QLEGACYS -G---------------KLIWKVTDYRVKKREAVEGHT--VSVFSQPFYTSRCGYRLCAR AYLNGDGSGK-GTHLSLYF--VVMRGEFDSLLQWPFRQR---VTLMLLDQS----GK--- -KNHIVETFKADP---NSS---SFKRP------------DGE-M--NIAS-GCPRFVSHS TLENSKN-TYIKDDTLFL---KVAVD-LTDLEDL-------------------------- ------------------------------------------------------------ --------------- >T_guttata_ENSTGUP00000003276 -------MA-CD----------------EPA-ALSGIFT--------------------- ----RQNSSSTSSLDFE----------PHADYRFVESLEERYKCAYCHLVLRNPHQT-G- ------------------------CGHRFCQQCILALR-------ELNA--VPTCPVDKE T----------IKMHE--VFKDNCCKREVLNLHVFCKN-FPDCSSKVILGRYQ------- --------------------------------------------EH--L-QQCLFECTQC TND-----GCRDRVLRKD----LKE----HLRQQCKFREERCQYCNTYVVFINI-E--NH E-----------------------------------------------------KNDCPD YPVPCLQ--NCS--QIILKKEIEKHHA-VCPEA--EVDCPYKQYGCH---V-K-VKRGKL AEHENSALREHMLQIL--DKNSRLEEQISDL---YKNLEYKEIKIQQLADAIKKCEKE-F RQYTQLFGNNSNLMVSTQ-ALASHLD----------------KSARLESQVKQLIQ---- MANQQQSKLDLQPLL----DTIENVKQKIA-LMETY--------DQRLVVLEDQ------ --------------------SSKH-----DLQINIHKAQLNKNEERF--K--LLEGTCYN -G---------------KLIWKITDYQKKKREAVEGRV--LSIASQPFYTSRCGYRLCAR AYLNGDGSGK-GTHISLYF--VVMRGEFDSLLLWPFKQK---VTLMLLDQS----GK--- -KNHIVDVFRADP---NSS---SFKRP------------DGE-M--NIAS-GCPRFVPHT VLESTKN-TYIRDDTLFL---KVVVD-LTDLEEL-------------------------- ------------------------------------------------------------ --------------- >G_gallus_ENSGALP00000016021 -------MA-CD----------------ELT-GVSGIFT--------------------- ----RQNSASAVSLDFE----------PDTDYKFVETLEDRYKCAYCHSVLHNPHQT-G- ------------------------CGHRFCQQCILTLR-------GLNA--VPTCPVDKE T----------IKMHE--VFKDNCCKREVLNLYVFCKN-LPDCNSKIILGRYQ------- --------------------------------------------EH--L-QQCLFESVQC TND-----GCCDQILRKD----LKD----HLSQHCKFREEMCQYCNKYVVLINI-K--NH E-----------------------------------------------------ENDCPD YPMPCLQ--NCS--QIILKKEIEKHHT-VCPET--EVDCPYKQYGCL---I-K-VKRGKL AEHENGALREHMLQIL--DKNSRLEEQISDL---YKSLECKEIKIQQLAEAVKKCEKE-F RQFTQLFGKNSNLMVSTQ-TLASHLD----------------KSARLESQVKQLIQ---- MANQQQSKLDLRPLF----DTIENVKQKIA-LMETY--------DQRLAVLESQ------ --------------------SSKH-----DLQINIHKAQLNKNEERF--K--LLEGTCYN -G---------------KLIWKITDYKMKKKEAVEGRV--LSIFSQPFYTSRCGYRLCAR AYLNGDGSGK-GTHVSLYF--VVMRGEFDSLLPWPFKQK---VTLMLLDQT----GK--- -KNHIVEVFRADP---NSS---SFKRP------------DGE-M--NIAS-GCPRFVPHT VLENTKN-TYVRDDTLFL---KVVVD-LTDLEEL-------------------------- ------------------------------------------------------------ --------------- >C_intestinalis_ENSCINP00000005981 -------M---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IPE---LNQ---- K---LK---EMIEEM----TRIRQKQNELERKL----STR--N-QENEQNFLAQ------ --------------------INGF-----EQQIGLYDVRIADMDQRF--Q--VLETTSYS -G---------------VALWKINNFQPRKREAESGRA--LSIYSQPFYTSRYGYKMCAR VYLNGDGMGK-GTHVSLFF--VLMKGEYDNLLPWPFRQK---VTLMLLDQG----LE--- -RRHLSDMFRPDP---TSS---SFTKP------------TSD-M--NIAS-GCPLFVAHN LIEGS---SYVKDDVIFI---RIHVD-TTDLETF-------------------------- ------------------------------------------------------------ --------------- >C_intestinalis_ENSCINP00000025605 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MDQRF--Q--VLETTSYS -G---------------VALWKINNFQRRKREAESGRA--LSIYSQPFYTSRYGYKMCAR VYLNGDGMGK-GTHVSLFF--VLMKGEYDNLLPWPFRQK---VTLMLLDQG----LE--- -RRHLSDMFRPDP---TSS---SFTKP------------TSD-M--NIAS-GCPLFVAHN LIEGS---SYVKDDVIFI---RIHVD-TTDLETF-------------------------- ------------------------------------------------------------ --------------- >A_carolinensis_ENSACAP00000017068 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------VEQQ-----DSLLAVKDVMISNLASRI--H--TLEQTTYD -G---------------CLLWKIPEVGLRSREARTGNR--PACYSPAFYTSRYGYKVCLK VFLNGEGTGT-GTHLSLFL--VLMKGEYDFQLKWPFRHK---VTFTLLDQD----NK--- --QHISTSFRPLE---SSS---SFQRP------------VNE-T--NVAS-GLPEFCPLN VLHSPRT-SYICNDTLAI---QAVID-M-------------------------------- ------------------------------------------------------------ --------------- >O_anatinus_ENSOANP00000013484 -------SMGSE----------------ELT-IGSRAFS--------------------- ----HQNSSSCISLDFE----------PDIQYQFVEQLEERYKCTFCHSVLHNPHQT-S- ------------------------CGHRFCQHCILSLR-------ELNN--FPTCPIDKK I----------IQLQE--VFKDNCCKREVLNLQVFCKN-APGCNSKMILGRYQ------- --------------------------------------------DH--L-QQCLFQPVQC SNE-----SCQEKVLRKD----MKD----HLGCHCKFREEKCQYCQKYVVAIDL-Q--NH E-----------------------------------------------------ENFCPD YPVSCPF--SCC--QIIPRTEVDEHIS-VCPEA--EQDCPYKQYGCL---I-K-DKRRNL REHENAALREHMLLVL--DKNSRLEEKISDL---HRSLEVKELKIQQLAEMVKKFEKE-F RQVMQLFSKNGNLLANTQ-ILANHID----------------KSTWLETQVRQLLH---- MANQQQSKFDLKSLM----ETIDTVKQKIA-LLETY--------DQRLVVLKDQ------ --------------------TRQH-----DAHINAHKAQLNKNEERF--K--LLEGTCYN -G---------------KLIWKVTDYKMKKREAMEGRS--VSIFSQPFYTSRCGYRLCAR AYLNGDGSGK-GTHLSLYF--VVMKGEFDSLLQWPFKQK---VTMMLLDQS----GK--- -KNHIVEIFKADP---NSS---SFKRP------------EGE-M--NIAS-GCPCFVDHS KLENVKN-TFIKEDTLFM---KVVVD-LTDLEEL-------------------------- ------------------------------------------------------------ --------------- >A_carolinensis_ENSACAP00000016112 -------MASED----------------LAC-QVPNFYI--------------------- ----RQNSTNAVSLDFE----------PDASYQFVEILEDRYKCTHCHLVLHNPHQT-G- ------------------------CGHRFCQRCIASLR-------ELSV--IPTCPVDKE I----------IKPHE--VFKDNCCKREVLNLQVYCRN-SPACNAKTSLGRYQ------- --------------------------------------------DH--L-QQCLFESVQC TNE-----GCCEKVLQKD----LKE----HLGLHCNYRKELCRYCNQPVTSINV-K--TH E-----------------------------------------------------RRDCPE YPLICPH--GCT--QTILMKEAEEHIL-VCPAV--EIDCPYKQYGCP---A-K-IKRGKV LEHENIYLREHMLQIL--DRNSKLEDQISEL---YKNLEHKEIKIQHLADMVKKCEKE-F RQFTQLYSKNNNLLASTQ-TLAIHID----------------KSACLETQVRQLVQ---- MANQQQSKFDLRPLL----ETVENIKQKVA-FLESY--------EQRLVVLEDL------ --------------------SSQH-----DIHLGLHKAQLNKNEERF--K--LLEGTSYN -G---------------KLIWKIVDYKTKKKEAVEGSC--LSIFSQPFYTSRCGYRLSTR AYLNGDGSGK-GTHVSLYF--VVMRGEFDSLLPWPFRQK---VTLMLLDQS----GK--- -KNHIVETFKADP---NSS---SFKRP------------EGE-M--NVAS-GCPRFVPHT LLENAKS-TYIKDDTIFL---KVVVD-LTDLEEL-------------------------- ------------------------------------------------------------ --------------- >M_domestica_ENSMODP00000003305 -------SLTSA----------------EYG-SASGDFL--------------------- ----PQNSSSYISLDFE----------PNIDYQFVEQLEERYKCASCHSVLHNPHQT-G- ------------------------CGHRFCENCILSLR-------ELNT--VSICPVDKE I----------IKPKE--VFKDNCCKREVLNLQVFCKN-APHCAAKMILGRYQ------- --------------------------------------------DH--L-LQCLFQSVQC SNE-----CCQERILRKD----LKN----HLELHCQFREEMCPFCNKDVVIIDL-Q--NH K-----------------------------------------------------EQFCPN YPVSCPN--NCL--QIITRTKVNEHIS-VCPEV--EQECAYKHYGCP---V-K-DKRSNL KKHENSALREHMLLVL--ERNSRLEEQIFDL---HKNLELKESKIQQLSETVKKFEKE-F RQFVQLFGKNGNLLASTQ-VLASHID----------------KSAWLETQVRELLE---- LANQQENKLDLKPLI----NTIDTIKQKIT-LLETY--------DQRLVTLEGQ------ --------------------TNRH-----DVHINVHKAQLNKNEERF--K--MLEGTCYN -G---------------KLIWKVTDYKMKKKEATEGRT--VSIFSQPFYTSRCGYRLCAR AYLNGDGSGK-GTHLSLYF--VVMKGEFDSLLQWPFKQR---VTMMLLDQS----GK--- -KNHITEIFKADP---NSS---SFKRP------------DGE-M--NIAS-GCPRFVAHS TLESTKN-TYIKEDTLFM---KVVVD-LSDLEDL-------------------------- ------------------------------------------------------------ --------------- >O_cuniculus_ENSOCUP00000007884 -------MAYSE----------------EPG-GIHLGFI--------------------- ----RQNSGSSISLDFE----------PNAEYRFVEQLEERYKCAFCHSVLHNPHQT-G- ------------------------CGHRFCQHCILSLR-------ELNT--VPICPVDKE V----------IRSQE--VFKDNCCKREVLNLHVYCKN-APGCNAKVILGRYQ------- --------------------------------------------EH--L-QQCLFQVVQC SHD-----SCQEPVLRRD----LNE----HLSAYCQFREEKCLYCKKDVVVMDL-Q--NH E-----------------------------------------------------ENLCPE YPVSCPN--KCL--QIIPRTEVNRHLA-VCPEA--EQDCPFKQYGCT---V-K-EKRGSL QEHEHSALREHMLLVL--EKNFRLEEQISDL---CKSLEQKESKIQQLAETVKKFEKE-F KQFAQLFGKNGSFLSNIQ-XXXXXXX----------------XXXXXXXXXXXXXX---- XXXXXXXXXXXXXXX----XXXXXXXXXXX-XXXXX--------XXXXXVLEGE------ --------------------TSKH-----DAHINIHKAQLNKNEERF--K--LLEGACYN -G---------------KLIWKVTDYKMKKKEAVDGHT--VSIFSQPFYTSRCGYRLCAR AYLNGDGSGK-GTHLSLYF--VVMRGEFDSLLQWPFRQR---VTLMLLDQS----GK--- -RNHIMETFKADP---NSS---SFKRP------------DGE-M--NIAS-GCPRFVAHS TLENAKN-TYIKEDTLFL---KVAVD-LTDLEDL-------------------------- ------------------------------------------------------------ --------------- >A_carolinensis_ENSACAP00000010321 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------LESKLRVFEG---- IASVLSKEMAVSRQK----SAAVRGQRGLD--------------QDMIRGLELK------ --------------------MADL-----QRCLVQKDAALCKLEERL--R--SSEEISYD -G---------------SFLWRITDVHRKCYEAVCGKM--RSFQSPAFYTSRYGHKLCMR IYLNGDGRSK-GSHASLFL--VLLRGEYDALLQWPFAHE---V----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------- >X_tropicalis_ENSXETP00000031605 -------IMACE----------------DLC-PLPVTLG--------------------- ----RQNSSAAVSLDFV----------PKQEYLFVEQLQDRYKCASCHLVLHNPHQT-G- ------------------------CGHRFCEKCISNLI-------ELSE--TPQCPIDME N----------IKSHE--IFKDNCCKREVLNLLVYCKN-SPACDVKVMLGRYQ------- --------------------------------------------EH--L-GQCLYEMTLC SND-----GCHDQMIRKE----LKG----HLESECKLRQEACIYCKQTMASINL-T--IH V-----------------------------------------------------GLYCQL YPVPCPN--ACP--VTCPRAELDKHLC-ECPEA--ELQCTFSNYGCN---V-M-VKRGKV KEHEDTFLRDHMLYVL--NRNMKLEEQVLGL---QQNLDLKEHQIQQLSDTVKWCEKE-C HQFGQFTGSNGNSLSSTK-TLASYID----------------KSMWLEEQV---IQ---- LVSKEHSRLDLRPIL----DTLESTKQRLS-TLEAY--------KDRIDNLDGQ------ --------------------FKKH-----DVLLSNHKMQMTSNEERF--R--LVEGTSYN -G---------------KLIWKITDYERKKREAMEGRA--VSIFSQHFYTSWCGYRLCAR AYLNGDGSGK-GSFLSLYF--VVMKGEFDSILLWPFKQK---VTLMLLDQS----GK--- -KNHITDVFRADP---NSS---SFKRP------------DSE-M--NIAS-GCPRFASHA QLENPKNGCYIK------------------------------------------------ ------------------------------------------------------------ --------------- >G_gorilla_ENSGGOP00000006994 ----------------------------------------------------MA------ --AASVTPPGSLELLQP----------GFSKTLLGTKLEAKYLCSACRNVLRRPFQA-Q- ------------------------CGHRYCSFCLASIL-------SSGP---QNCAACVH EGIYEEGISI-LESSS--XXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXX------- -------------------------------------------SCH--E-GRCPLMLTEC PA-------CKGLVRLGE----KER----HLEHECPERSLSCRHCRAPCCGADV-K--AH H------------------------------------------------------EVCPK FPLTCDG--CGK--KKIPREKFQDXVK-TCGKC--RVPCRFHAVGCL---E-T-VEGEKQ QEHEAQWLREHLAMLL--SSVLEAKPLSGDQ----------------------------- ---------------------------------SHAGSELLQRCESLEKKTATFEN---- IVCVLNREVERVAMT----AEACSRQHRLD--------------QDKIEALSSK------ --------------------VQQL-----ERSIGLKDLAMADLEQKV--L--EMEASTYD -G---------------VFIWKISDFARKRQEAVAGRT--PAIFSPXXXXXXXXXXXXXX XXXXXXXXXX-XXXXXXXX--XXXXXXXXXXXXXXXXXX---VTLMLLDQN----NR--- --EHVIDAFRPXV---TSS---SFQRP------------VND-M--NIAS-GCPLFCPVS KMEA-KN-SYVRDDAIFI---KAIVD-LTGL----------------------------- ------------------------------------------------------------ --------------- >O_latipes_ENSORLP00000001368 ------------------------------------------------------------ ---------LAGRLQTH----------GVVRNHFVMKLKEEFICPICKGVVLNPQQN-S- ------------------------CGHIYCFHCLQGLL-------ESSLLSGPVCPVEKA A----------ITPSE--VFQDNCCKREISSLEVYCTN-SPLCTSVLALNQLQ------- --------------------------------------------EH--L-KSCQYEQLLC SNP-----GCTELLQRRL----LQE----HLNATCPHRRESCPHCLQPFQLSVI-Q--DH V-----------------------------------------------------QSSCPK VKGGCPD--GCS--TLVPKNRLTEHGE-SCPEV--HTDCSFKMFGCS---V-K-GKRRKV KLHEEAAVCHHVLLVL--KSSAHLEQQVVFV---QKEALLRQQEVQTDTLLLSDLQEQ-L GSVLQQSRSQEHIVATAQACLDEHRA----------------DILEMENELLAAET---- ----------LREHIGNQTGNSRSVKLRSA-TLCTGVFLFYIKCHLMSATLEEN------ --------------------RKRH-----SGLLELHVAQLALNKQHL--Q--ELELTSYD -G---------------RLIWKIKDFQKRREAEATGQH--PCLSSVPFHTGRCGYKMAMK AYLNGDGEGR-GTHLSLYV--VLMPGDFDALLPWPFKQT---VSLSVLDQS----GA--- -RNHQSFNFRPDP---TNT---CFHQP------------AAE-SASNVAV-GFPCFISLD ALEAPGNAVYVKDDTLFV---KVKVD-TTGLE---------------------------- ------------------------------------------------------------ --------------- >G_aculeatus_ENSGACP00000025883 ------------------------------------------------------------ --------------------------------KFVSPLREEFVCPVCGGVVLNPQQN-S- ------------------------CGHIFCFLCLRALR-------ESSPASGPVCPVDGA A----------ITPAG--VFQDNCCKREISGLEVYCVN-FPACASVVTLRRLQ------- --------------------------------------------VE--P-THKQSDNLVS PE------DVQRFLLKNQQLCPLQE----HLADTCPLRGEPRPHRQPPQRLTFI-Q--DR V-----------------------------------------------------QSSC-- LQVDCPE--SCS--PKAPRHKLE-----SCPEQVEQVDCSYKKFGCS---V-Q-DTRGRV KLHEDAAVHRHMLLVL--RSNTHLEQQVEGL---REEALLMQQEVQTDGLLLAGLQKT-I RPLLQQKDGRELTVSAAQVNTYQDSY----------------ILGRFPAFLKVVLS---- LLSRGSFELEELRKS----VDAVIQEVSAAEAL-----------RRHLGTLEED------ --------------------LKQH-----SGLLDLHAAQLGGNERHL--R--ELGGASFD -G---------------RLIWKIDDFTNRREAEVRGRP--PCLSSVPFHAGTCGYKLASR VYLNGDGEGR-GTHLSLYV--VLMPGDFDALLPWPFRQT---VSLSLLDQS----GA--- -ANHRSLSFRPDP---SSK---SFGRP------------AAE-SAGNVAV-GFSCFLPLG ELEPRHNAEYVKDDALFV---KVKVD-TAGLDPL-------------------------- ------------------------------------------------------------ --------------- >D_rerio_ENSDARP00000014326 ------------------------------------------------------------ -------------------------------------LEQQFICPSCGGIVLNPHQT-G- ------------------------CGHIFCAQCVKAYT-------ENGG--SSKCPLDSI P----------IKPEE--IFQDNCCKRELLNLEVFCTN-APECTQRFSLCNLQ------- --------------------------------------------DH--L-KACPHERVRC SHS-----DCSDIVLRKN----LLE----HQRNACSYRLETCHYCRQNFPVSQMMQ--GH Q-----------------------------------------------------KSSCPD VEVPCSN--NCT--QMIKRHQLQAHAD-ECLEV--ETDCVYKNYGCT---V-R-DKRGKV QVHENTEFSAHVRLVL--EKLCEQTLCSLTM----------QSRVSTFSCDRRSVEEQ-- ----------------------------------------RVRICSVQRELRDLRV---- LGSELKEELPRL--------------------------------QASLDSLRQQ------ -----------------------------VAVTESLREHLVALKQHS--T--FLESSSYD -G---------------KLIWKVRDYWHRKESG-------AALSSSPFYTSRSGYKLSVR AYLGGDGSGR-GSHMSLYI--TIMRGDFDSFLPWPFRQN---ITLTLLDQS----GT--- -RNHMSHTFIPDV---NSD---SFHRP------------TSD-A--NVAT-GFTRFISHC DLENPRNAVFVRDETLFI---KVKV----------------------------------- ------------------------------------------------------------ --------------- >C_intestinalis_ENSCINP00000027041 ------------------------------------------------------------ -----------------------------------------------MPINTNPWMR--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------GSE---V-E-DEGEDT NRNESRSLSQPASLET-----------------PDINGQHSNEDIAILNNVPAVLHTD-- ---------------------------------------LTQKGEEFAREIAQIKE---- KQHVLERKNESISSS----RE-----------------------QMTPESLSQM------ --------------------VDAF-----ERQLGMYDVRIAEMDRRF--Q--ILETTSYS -G---------------SLIWKIRDFSRRKREAVSGRA--LSLYSQPFYTSRYGYKMCAR VYLNGDGMGK-GTHMSLFF--VVMKGEYDALLTWPFRQK---VSV--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------- >P_troglodytes_ENSPTRP00000015252 ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------L-------SEGV---FKCPEDQL P----------LDYAK--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ------- --------------------------------------------GH--L-NTCSFNVIPC PN------RCPMKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SH EGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPR LPVACPN--QCGV-GTVAREDLPGHLKDSCNTA--LVLCPFKDSGCK---H-R-CPKLAM ARHVEESVKPHLAMMC-------------------------------------------- ------------------------------------------------------------ -------------------------------------------------ALVSR------ -----------------------------------QRQELQELRREL--E--EL-SVGSD -G---------------VLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVS AFLNGNGSGE-GTHLSLYI--RVLPGAFDNLLEWPFARR---VTFSLLDQSDPGLAK--- -PQHVTETFHPDP---NWK---NFQKP-----GTWRGS-LDE-S--SLGF-GYPKFISHQ DIRKR---NYVRDDAVFI---RAAVELPRKILS--------------------------- ------------------------------------------------------------ --------------- >P_pygmaeus_ENSPPYP00000009119 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------EGV---FKCPEDQL P----------LDYAK--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ------- --------------------------------------------GH--L-NTCSFNVIPC PN------RCPMKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SH EGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCSKEFVFDTIQSHQYQCPR LPVACPN--QCGV-GTVAREDLPGHLKDSCNTA--LVLCPFKDSGCK---H-R-CPKLAM ARHVEESVKPHLAMMC-------------------------------------------- ------------------------------------------------------------ -------------------------------------------------ALVSR------ -----------------------------------QRQELQELRREL--E--EL-SVGSD -G---------------VLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVS AFLNGNGSGE-GTHLSLYI--RVLPGAFDNLLEWPFARR---VTFSLLDQSDPGLAK--- -PQHVTETFHPDP---NWK---NFQKP-----GTWRGS-LDE-S--SLGF-GYPKFISHQ DIRKR---NYVRDDAVFI---RAAVELPRKILS--------------------------- ------------------------------------------------------------ --------------- >M_mulatta_ENSMMUP00000028200 ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------SEGV---FKCPEDQL P----------LDYAK--IYPDPELEVQVLGLPIRCIHSEEGCRWNGPLRHLQ------- --------------------------------------------GH--L-NTCSFNVVPC PN------RCPMKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SH EGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPR LPVPCPN--QCGV-GTVAREDLPGHLKDSCSTA--LVLCPFKDSGCK---H-R-CPKLAM ARHVEESVKPHLAMMC-------------------------------------------- ------------------------------------------------------------ -------------------------------------------------ALVSR------ -----------------------------------QRQELQELRREL--E--EL-SVGSD -G---------------VLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVS AFLNGNGSGE-GTHLSLYI--RVLPGAFDNLLEWPFARR---VTFSLLDQSDPGLAK--- -PQHVTETFHPDP---NWK---NFQKP-----GTWRGS-LDE-S--SLGF-GYPKFISHQ DIRKR---NYVRDDAVFI---RAAVELPRKILS--------------------------- ------------------------------------------------------------ --------------- >B_taurus_ENSBTAP00000016271 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------Q--IYPDPELEVQVLGLSIRCIHSEEGCRWNGPLRHLQ------- --------------------------------------------GH--L-NTCSFNVVPC PN------RCPAKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAF-E--SH EGVCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPR LPVPCPN--QCGV-GTVAREDLPGHLKDSCSTA--LVLCPFKDSGCK---H-R-CPKLAM ARHVEESVKPHLAMMC-------------------------------------------- ------------------------------------------------------------ -------------------------------------------------ALVSR------ -----------------------------------QRQELQELRREL--E--EL-SVGSD -G---------------VLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVS AFLNGNGSGE-GTHLSLYI--RVLPGAFDNLLEWPFARR---VTFSLLDQSDPGLAK--- -PQHVTETFHPDP---NWK---NFQKP-----GTWRGS-LDE-S--SLGF-GYPKFISHQ DIRKR---NYVRDDAVFI---RASVELPRKILS--------------------------- ------------------------------------------------------------ --------------- >H_sapiens_ENSP00000262395 ------------------------------------------------------------ --------------------------MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVST- ------------------------CGHRFCDTCLQEFL-------SEGV---FKCPEDQL P----------LDYAK--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ------- --------------------------------------------GH--L-NTCSFNVIPC PN------RCPMKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SH EGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPR LPVACPN--QCGV-GTVAREDLPGHLKDSCNTA--LVLCPFKDSGCK---H-R-CPKLAM ARHVEESVKPHLAMMC-------------------------------------------- ------------------------------------------------------------ -------------------------------------------------ALVSR------ -----------------------------------QRQELQELRREL--E--EL-SVGSD -G---------------VLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVS AFLNGNGSGE-GTHLSLYI--RVLPGAFDNLLEWPFARR---VTFSLLDQSDPGLAK--- -PQHVTETFHPDP---NWK---NFQKP-----GTWRGS-LDE-S--SLGF-GYPKFISHQ DIRKR---NYVRDDAVFI---RAAVELPRKILS--------------------------- ------------------------------------------------------------ --------------- >T_nigroviridis_ENSTNIP00000019321 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------VKLTRRD----LPD----HLQHDCPKRKVKCEFCGSEFTGEAY-E--NH QGVCPQESVYCENKCGARMMRRLLSQHGMAECPKRTQPCKYCGKEFVFDTIQNHQYHCPR FPVQCPN--QCGT-PNIAREDLANHVKDNCGSA--LVLCPFKDAGCK---H-R-CPKLAI GRHLEDTTKSHLTMMC-------------------------------------------- ------------------------------------------------------------ -------------------------------------------------NLVGR------ -----------------------------------QRQEILELRREM--E--EL-SVSHD -G---------------ILIWKLNDYSRKLQEAKIRSN--HEFFSPPFYTHRYGYKLQVS AFLNGNGSGE-GSHLSVYI--RVLPGEYDNLLEWPFSYK---VTFSLLDQSDPSLSK--- -PQHITETFNPDP---NWK---NFQKP-----NSTRNS-LDE-S--TLGF-GYPKFISHE EIKKR---NYIRDNCIFI---KASIEIPQKIMA--------------------------- ------------------------------------------------------------ --------------- >G_gorilla_ENSGGOP00000016344 ------------------------------------------------------------ --------------------------MPGFDYKFLEKPKRRLLCPLCGKPMREPVXXPP- ------------------------CGHRFCDTCLQEFL-------SEGV---FKCPEDQL P----------LDYAK--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX------- --------------------------------------------XX--X-XXXXXXXXXX XX------RCPMKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SH EGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPR LPVACPN--QCGV-GTVAREDLPGHLKDSCNTA--LVLCPFKDSGCK---H-R-CPKLAM ARHVEESVKPHLAMMC-------------------------------------------- ------------------------------------------------------------ -------------------------------------------------ALVSR------ -----------------------------------QRQELQELRREL--E--EL-SVGSD -G---------------VLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVS AFLNGNGSGE-GTHLSLYI--RVLPGAFDNLLEWPFARR---VTFSLLDQSDPGLAK--- -PQHVTETFHPDP---NWK---NFQKP-----GTWRGS-LDE-S--SLGF-GYPKFISHQ DIRKR---NYVRDDAVFI---RAAVELPRKILS--------------------------- ------------------------------------------------------------ --------------- >E_caballus_ENSECAP00000009502 ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------SEGV---FKCPEDQL P----------LDYAK--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ------- --------------------------------------------GH--L-NTCSFNVVPC PN------RCPTKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAF-E--SH EGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCAKEFVFDTIQSHQYQCPR LPVPCPN--QCGV-GTVAREDLPGHLKDSCSTA--LVLCPFKDSGCK---H-R-CPKLAM ARHVEESVKPHLAMMC-------------------------------------------- ------------------------------------------------------------ -------------------------------------------------ALVSR------ -----------------------------------QRQELQELRREL--E--EL-SVGSD -G---------------VLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVS AFLNGNGSGE-GTHLSLYI--RVLPGAFDNLLEWPFARR---VTFSLLDQSDPGLAK--- -PQHVTETFHPDP---NWK---NFQKP-----GTWRGS-LDE-S--SLGF-GYPKFISHQ DIRKR---NYVRDDAVFI---RASVELPRKILS--------------------------- ------------------------------------------------------------ --------------- >D_rerio_ENSDARP00000013849 ------------------------------------------------------------ --------------------------MPGFDYKFLEKPKRRFQCPLCSKAMREPVQVST- ------------------------CGHRFCDTCLQEFL-------SEGV---FKCPEDQL P----------LDYAK--IYPDPELEQQILALPIRCIHSEEGCRWTGQMKQLQ------- --------------------------------------------SH--F-STCAFNVIPC PN------RCSVKLTRRD----LPE----HLQHDCPKRKVKCEFCGSEFTGEAY-E--NH QGICPQESVYCENKCGARMMRRLLSQHTMTECPKRTQPCKYCGKEFVYDTIQNHQYHCPR FPVQCPN--QCGT-PNIAREDLANHVKESCGSA--LVLCPFKEAGCK---H-R-CPKMAI GRHLEESTKSHLTMMC-------------------------------------------- ------------------------------------------------------------ -------------------------------------------------SLVGR------ -----------------------------------QRQEILELRREM--E--EL-SVSHD -G---------------VLIWKLTDYSRKLQEAKLRNN--HEFFSPPFYTHRYGYKLQVS AFLNGNGSGE-GSHLSIYI--RVLPGEYDNLLEWPFSYK---VTFSILDQSDPSLSK--- -PQHITETFNPDP---NWK---NFQKP-----CSSRNS-LDE-S--TLGF-GYPKFISHE EIKKR---NYIRDNSIFL---KASIEIPQKIMA--------------------------- ------------------------------------------------------------ --------------- >B_taurus_ENSBTAP00000050075 ------------------------------------------------------------ --------------------------MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVST- ------------------------CGHRFCDTCLQEFL-------SEGV---FKCPEDQL P----------LDYAK--IYPDPELEVQVLGLSIRCIHSEEGCRWNGPLRHLQ------- --------------------------------------------GH--L-NTCSFNVVPC PN------RCPAKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAF-E--SH EGVCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPR LPVPCPN--QCGV-GTVAREDLPGHLKDSCSTA--LVLCPFKDSGCK---H-R-CPKLAM ARHVEESVKPHLAMMC-------------------------------------------- ------------------------------------------------------------ -------------------------------------------------ALVSR------ -----------------------------------QRQELQELRREL--E--EL-SVGSD -G---------------VLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVS AFLNGNGSGE-GTHLSLYI--RVLPGAFDNLLEWPFARR---VTFSLLDQSDPGLAK--- -PQHVTETFHPDP---NWK---NFQKP-----GTWRGS-LDE-S--SLGF-GYPKFISHQ DIRKR---NYVRDDAVFI---RASVELPRKILS--------------------------- ------------------------------------------------------------ --------------- >M_musculus_ENSMUSP00000017530 ------------------------------------------------------------ --------------------------MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVST- ------------------------CGHRFCDTCLQEFL-------SEGV---FKCPEDQL P----------LDYAK--IYPDPELEVQVLGLAIRCIHSEEGCRWSGPLRHLQ------- --------------------------------------------GH--L-NTCSFNVVPC PN------RCPAKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SH EGVCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCAYCTKEFVYDTIQSHQYQCPR LPVPCPN--QCGV-GTVAREDLPTHLKDSCSTA--FVLCPFKESGCK---H-R-CPKLAM GRHVEESVKPHLAMMC-------------------------------------------- ------------------------------------------------------------ -------------------------------------------------ALVSR------ -----------------------------------QRQELQELRREL--E--EL-SIGSD -G---------------VLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVS AFLNGNGSGE-GTHLSIYI--RVLPGAFDNLLEWPFARR---VTFSLLDQSDPGLAK--- -PQHVTETFHPDP---NWK---NFQKP-----GTWRGS-LDE-S--SLGF-GYPKFISHQ DIRKR---NYVRDDAVFI---RASVELPRKILS--------------------------- ------------------------------------------------------------ --------------- >G_aculeatus_ENSGACP00000014759 ------------------------------------------------------------ --------------------------MPGFDYKFLEKPKRRFQCPLCSKAMREPVQVST- ------------------------CGHRFCDTCLQEFL-------SEGV---FKCPEDQL P----------LDYAK--IYPDPELEQQILALPIRCIHSEEGCRWTGQMKQLQ------- --------------------------------------------GH--F-STCAFNVIPC PN------RCSVKLTRRD----LPD----HLQHDCPKRKVKCEFCGSEFTGEAY-E--NH QGVCPQESVYCENKCGARMMRRLLSQHGLAECPKRTQPCKYCGKEFVFDTIQNHQYHCPR FPVQCPN--QCGT-PNIAREDLANHVKDNCGSA--LVLCPFKDAGCK---H-R-CPKLAI GRHLEDTTKSHLTMMC-------------------------------------------- ------------------------------------------------------------ -------------------------------------------------NLVGR------ -----------------------------------QRQEILELRREM--E--EL-SVSHD -G---------------VLIWKLSDYSRKLQEAKLRSN--HEFFSPPFYTHRYGYKLQVS AFLNGNGSGE-GSHLSVYI--RVLPGEYDSLLEWPFSYK---VTFSILDQSDPSLSK--- -PQHITETFNPDP---NWK---NFQKP-----SSSRNS-LDE-S--TLGF-GYPKFISHD EIKKR---NYIRDNCVFI---KASIEIPQKIMT--------------------------- ------------------------------------------------------------ --------------- >R_norvegicus_ENSRNOP00000018468 ------------------------------------------------------------ --------------------------MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVST- ------------------------CGHRFCDTCLQEFL-------SEGV---FKCPEDQL P----------LDYAK--IYPDPELEVQVLGLAIRCIHSEEGCRWSGPLRHLQ------- --------------------------------------------GH--L-NTCSFNVVPC PN------RCPAKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SH EGVCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCAYCTKEFVYDTIQSHQYQCPR LPVPCPN--QCGV-GTVAREDLPTHLKDSCSTA--FVLCPFKESGCK---H-R-CPKLAM GRHVEESVKPHLAMMC-------------------------------------------- ------------------------------------------------------------ -------------------------------------------------ALVSR------ -----------------------------------QRQELQELRREL--E--EL-SVGSD -G---------------VLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVS AFLNGNGSGE-GTHLSIYI--RVLPGAFDNLLEWPFARR---VTFSLLDQSDPGLAK--- -PQHVTETFHPDP---NWK---NFQKP-----GTWRGS-LDE-S--SLGF-GYPKFISHQ DIRKR---NYVRDDAVFI---RASVELPRKILS--------------------------- ------------------------------------------------------------ --------------- >T_rubripes_ENSTRUP00000012878 ------------------------------------------------------------ --------------------------MPGFDYKFLEKPKRRFQCPLCSKAMREPVQVST- ------------------------CGHRFCDTCLQEFL-------SEGV---FKCPEDQL P----------LDYAK--IYPDPELEQQILALAIRCIHSEEGCRWTGQMKQLQ------- --------------------------------------------GH--F-STCAFNVIPC PN------RCSVKLTRRD----LPD----HLQHDCPKRKVKCEFCGSEFTGEAY-E--NH QGVCPQESVYCENKCGARMMRRLLSQHGMAECPKRTQPCKYCSKEFVFDTIQNHQYHCPR FPVQCPN--QCGT-PNIAREDLANHVKDNCGSA--LVLCPFKDAGCK---H-R-CPKLAI GRHLEDTTKSHLTMMC-------------------------------------------- ------------------------------------------------------------ -------------------------------------------------NLVGR------ -----------------------------------QRQEILELRREM--E--EL-SVGHD -G---------------ILIWKLNDYSRKLQEAKIRSN--HEFFSPPFYTHRYGYKLQVS AFLNGNGSGE-GSHLSVYI--RVLPGEYDNLLEWPFSYK---VTFSLLDQSDPSLSK--- -PQHITETFNPDP---NWK---NFQKP-----SSTRNS-LDE-S--TLGF-GYPKFISHE EIKKR---NYVRDNCIFI---KASIEIPQKIMA--------------------------- ------------------------------------------------------------ --------------- >O_latipes_ENSORLP00000005579 ------------------------------------------------------------ --------------------------MPGFDYKFLEKPKRRFQCPLCSKAMREPVQVST- ------------------------CGHRFCDTCLQEFL-------SEGV---FKCPEDQL P----------LDYAK--IYPDPELEQQILSLPIRCIHSEEGCRWTGQMKQLQ------- --------------------------------------------GH--F-STCAFNVIPC PN------RCSVKLTRRD----LPD----HLQHDCPKRKVKCEFCGSEFTGEAF-E--NH QGVCPQESVYCENKCGARMMRRLLSQHGMAECPKRTQPCKYCGKEFVFDTIQNHQFHCPR FPVQCPN--QCGT-PNIAREDLANHVKDNCGSA--LVLCPFKDAGCK---H-R-CPKLAI GRHLEDTTKSHLTMMC-------------------------------------------- ------------------------------------------------------------ -------------------------------------------------NLVSR------ -----------------------------------QRQEILELRREM--E--EL-SVSHD -G---------------VLIWKLNDYSRKLQEAKLRSN--HEFFSPPFYTHRYGYKLQVS AFLNGNGSGE-GSHLSVYI--RVLPGEYDNLLEWPFSYK---VTFSILDQSDPSLSK--- -PQHITETFNPDP---NWK---NFQKP-----CSTRNS-LDE-S--TLGF-GYPKFISHE EIKKR---NYIRDNCIFI---KASIEIPQKIMG--------------------------- ------------------------------------------------------------ --------------- >M_domestica_ENSMODP00000024090 ------------------------------------------------------------ --------------------------MPGFDYKFLEKPKRRLLCPLCAKAMREPVQVST- ------------------------CGHRFCDTCLQEFL-------SEGV---FKCPEDQL P----------LDYAK--IYPDPELEAQVLSLPIRCIHSEEGCRWTGALRQLQ------- --------------------------------------------VH--L-SSCGYNVVAC PN------RCNGKLSRRD----LPS----HLQHECPKRRLKCDFCGIDFTGEAF-E--SH EGVCPQESVYCENKCGARMMRRLLGQHMMAECPKRTQPCAYCTKEFVYDTIQNHQHQCPR YPIPCPN--QCGM-GSIPREDLNSHLKENCSTV--PVLCPFKDAGCK---H-R-CPKLAM GRHMEESVKPHLAMMC-------------------------------------------- ------------------------------------------------------------ -------------------------------------------------ALVSR------ -----------------------------------QRQELQELRRDV--E--EL-SVGCD -G---------------VLIWKIGGYGRRLQEAKARAN--HECFSPAFYTHKYGYKLQVS AFLNGNGSGE-GTHLSLYI--RVLPGAFDNLLEWPFARR---VTFSLLDQSDPAVAK--- -PQHVTETFHPDP---HWK---NFQKP-----GTWRGS-MDE-S--ALGF-GYPKFISHQ DIRKR---NYVRDDAVFI---RASVELPKKILS--------------------------- ------------------------------------------------------------ --------------- >X_tropicalis_ENSXETP00000056667 ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------SEGV---FKCPEDQL P----------LDYAK--IYPDRDLETQVMGLSIRCIHSEEGCRWSGQLKQLQ------- --------------------------------------------PH--L-NICAFNVIPC PN------RCSTKLIRRD----LPE----HMQHDCPKRKVRCEFCGADFTGEAY-E--DH QGCCPQESVYCENKCGARMMRRVLSQHSLVECPKRTQPCPYCNKEFVFDTIQSHQYQCPR YPTPCPN--QCGI-ASIAREDLSNHLKDSCSSA--LVLCPFKDSGCK---H-R-GPKITI SRHLEENMRAHLSMMS-------------------------------------------- ------------------------------------------------------------ -------------------------------------------------SLVSR------ -----------------------------------QRQEILELRKQV--E--EL-SVSSE -G---------------VLIWKISDYSRKVQEAKVRGN--FESFSPPFYTHKYGYKLQVS AFLNGNGSGE-GSYLSVYI--RVLPGEYDNLLEWPFSYR---VTFSLLDQSDPSLSK--- -PQHITETFNPDP---NWK---NFQKP-----TGSRNS-LDE-S--TLGF-GYPKFISHE DIRKR---NYVRDNAIFL---RASVEIPQKIIA--------------------------- ------------------------------------------------------------ --------------- >A_gambiae_AGAP010017-PA -------M---------------------------------------------------- -------------------------------VRSLSQWTKTLSFPARISPNRNSKDC-NV NVLPITPPPAPPRNKST--S----TSSASTMSSSSSPS-------SSSS---SPTP---P PNVP-------ITEISQIIYPDPESEKAIMGSLVFCIHHKQGCKWSDELRKLK------- --------------------------------------------AH--L-NTCKHDAIQC PN------KCGSQIPRVM----MTD----HLAFTCILRRAICEFCNVEFTGIGL-E--EH AGTCSSEPIYCESKCGTRVLRGRMSIHRAKDCAKRLRRCPHCGREFCADTLAAHGATCPR SPIPCPQ--RCDA-GPFARADLDAHLRDECKAL--TVPCTFKEAGCR---F-K-GPRHLL EAHLEANTSAHLSLMV-------------------------------------------- ------------------------------------------------------------ -------------------------------------------------ALSGR------ -----------------------------------QGQQINMLKSAM--A--KL-STNYT -G---------------TLLWKITDWSVKMQEAKTKDG--LELVSPPFYTSQYGYKLQAS MFLNGNGPGE-GTHVSVYI--KVLPGEYDALLKWPFSHS---VTFTLFEQG--TLGSGGG GQGGVAESFVPDP---TWE---NFQRP----------S-TEP-D--ALGF-GFPRFVSHE LLNRR---PFVRDDTVFL---RVKVD-PSKIVAV-------------------------- ------------------------------------------------------------ --------------- >A_aegypti_AAEL006649-PA -------M---------------------------------------------------- -------------------------------VRSLSQWTKTLSFPARISPNRNSKEC-SV NVLPITPPPAPPRNKSTTST----TSSASSSTSALSHS-------SATS---SPSP---P PNVP-------ITEISQIIYPDPESEKAIMGSLVFCIHHKQGCKWSDELRKLK------- --------------------------------------------AH--L-NTCKHDAIQC PN------KCGSQIPRVM----MTD----HLAFTCILRRAICEFCNVEFTGIGL-E--EH AGTCSSEPIYCESKCGTRVVRGRMSIHRAKDCAKRLRRCPHCSREFSADTLSAHGATCPR SPVPCPQ--RCDA-GPFARADLEGHLRDECKAL--SVPCTFKEAGCR---F-K-GPRHLL EAHLESNTSSHLSLMV-------------------------------------------- ------------------------------------------------------------ -------------------------------------------------ALSGR------ -----------------------------------QGQQINMLKNAM--A--KL-STNYT -G---------------TLLWKITDWSAKMVEAKSKDG--LELVSPPFYTSQYGYKLQAS MFLNGNGPGE-GTHVSVYI--KVLPGEYDALLKWPFSHS---VTFTLFEQG--TLGS--- -QGGVAESFVPDP---SWE---NFQRP----------S-TEP-D--ALGF-GFPRFVSHE LLNRR---PFVREDTVFL---RVKVD-PSKIVAV-------------------------- ------------------------------------------------------------ --------------- >D_rerio_ENSDARP00000056877 ------------------------------------------------------------ --------------------------MPGLDLKFLERPRRKFYCPLCEKPMREPVQVST- ------------------------CGHRFCDTCLQEYL-------SEGV---FTCPEDQL P----------LDYAK--IFPDLELEQQILSLPIRCIHSEEGCRWTAQNKLLQ------- --------------------------------------------AH--L-SVCEFNVVSC PN------RCSVKLLRRE----LPE----HLQHDCAKRKLHCDHCGEQFTGEAY-E--NH QGVCPEESVYCENKCGARMVRRLLAQHSVSECLKRKLPCRYCKKEFLYDTIQNHQQQCPR FPMQCPN--RCGT-PGITRDTLMAHVKEGCSTA--MVLCPFKEAGCK---H-R-SPKTGV ARHLEEAAPTHLSLLC-------------------------------------------- ------------------------------------------------------------ -------------------------------------------------GLVNR------ -----------------------------------QRLELRDLRRRM--E--EL-SGSRD -G---------------TLLWKLTDFSQRLQEAKTRTSGCLELFSPAFYSHNYGYRLQVS AFLNGNGSGE-DTHMSVYL--RVLPGEYDGLLEWPFPYR---VSFSLLDQCDPALTK--- -PQHITETFSPDP---TWK---NFQRPRPGALGSIRGGCLDE-S--MLGF-GYPKFISHE EMKKR---NYIRDNAVFI---KASIDVVQKILN--------------------------- ------------------------------------------------------------ --------------- >D_melanogaster_FBpp0111838 -------MPAPPATVKPATGHTTKLNNGKSSNSNSNHTLSNSIAHLSDSRTNLTVNTPTT CQRLSEMFRRSIASSTQ----------SSSRENTYEEWTKTLSFPSRLSPNRNSKDC-ST LASPV-PPPTPPRNKTTSGSGNCATSRSSSSTVSSSHS-------SSHS---SPTPGNNN NNMP-------ITELEQIIYPGPDP-KHIMGSLVFCIHHKQGCKWSDELRKLK------- --------------------------------------------GH--L-NACKHDATQC PN------KCGAQIPRIM----MTD----HLQYTCTMRRTRCEFCQSEFSGAGL-E--EH NGSCGQEPVYCEAKCGQRILRGRMTLHKSKDCAKRLRRCAHCQREFSADTLPLHAAQCPR APLACPQ--RCDA-GPIPRGELEAHLRDECQSL--AVSCSFKEAGCR---F-K-GPRQML EAHLESNAAAHLSLMV-------------------------------------------- ------------------------------------------------------------ -------------------------------------------------ALSSR------ -----------------------------------QGQQIQMLKSAV--S--KL-SINYT -G---------------TLLWKITDWSAKMAEARGKDG--LELVSPPFYTSQYGYKLQAS MFLNGNGPGE-NTHVSVYI--KVLPGEYDALLKWPFSHS---ITFTLFEQG--AQSG--- -QGGVAESFVPDP---TWE---NFQRP----------S-NEP-D--QLGF-GFPRFISHE LLHSR---PFIKGDTVFL---RVKVD-PSKIVAV-------------------------- ------------------------------------------------------------ --------------- >O_anatinus_ENSOANP00000019424 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------PCPYCTKEFVFDTIQNHQYQCPR FPLPCPN--QCGT-GAVAREDLPGHLKENCNTA--PVLCPFKDAGCK---H-R-CPKLAM SRHLEDSVKLHLGLTW-------------------------------------------- ------------------------------------------------------------ -------------------------------------------------ALVSR------ -----------------------------------QRQELQELRRDV--E--EL-AAGSD -G---------------VLVWRIGGYGRRLQEARGRPN--HECLSRPFYTHKYGYRLQVS AFLNGNGSGE-GTHLSLYI--RVLPGDYDNLLEWPFALR---VTFSLLDQSDPSLSK--- -PQHVTETFHPDP---HWK---NFQKP-----GAWRGS-GSSGA--ALGF-GYPKFISHE DIRKR---DYVRDDAVFI---RAAVELPRRILA--------------------------- ------------------------------------------------------------ --------------- >M_domestica_ENSMODP00000024756 ----------------MSLLNCEDSCGTSHPESDCCAGV-ASACSTGTKDD--S---VNG ST--IPGNLPSSLREEI----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- ------------------------CGHRFCKACIVKSI-------RDAG---HKCPVDNA I----------LLETQ--LFPDNFAKREILSLTVKCPNEG--CLLKMELRHLE------- --------------------------------------------DH--Q-THCEFALAEC PQ-------CHLPFRKYL----LHN----HMVVECPRRQVSCVNCAAPMPFEEK-EAKFH D------------------------------------------------------QNCPL ATVFCEY---CS--TMLIREQMPNHYDIDCPVA--PIPCTFSTFGCR---E-K-MPRNHL ARHLQEDTLAHMRMMA--QAIENISIAAFNPK--LH---QREASSYDTS----------- -------PLPRTP----------------------------------YPGPQNFQE---- TIQQLESRLVIQDHQ--------------------------------IRELTAK------ --------------------METQ-----SACVGDLKRTIRTLEDRI--A--EMEAQQCN -G---------------IYIWKINNFGMHLKSQEEEKP--VVIHSPGFYTGKPGYKLCMR LHLQLPSAQRCANYISLFV--HTMQGEYDSHLPWPFQGT---IRLTILDQSEAP-VR--- --QNHEEIMDAKP---ELL---AFQRP------------TIP-R--NPKGFGYVTFMHLQ ALKQR---TFIKDDTLLV---RCEVLTRLDMNSL-------------------------- ---------------------------------RREG--FQPRSTDAGV----------- --------------- >C_intestinalis_ENSCINP00000003738 ------------------------------------------------------------ -------------------------------------------CVECKYTLEFPVALSN- ------------------------CEHHACSQCVSRLW-------KIS----RSCPLDGK V----------IDRNE--VTIDEKLQIELNNLNMVCPYKHCGCHWEGMFFDFK------- --------------------------------------------SH--Y-DECLYTEEVC SN------DCGFRCSKHL----MDN----HLQIECSKRLVVCEFCALHLKAENEIE---H L------------------------------------------------------KSCIR FPVTCPK--KCGT-KEIPREELNAHLELDCQLA--DKVCPYETVGCT---F-T-CSREKM ATHVDECFRKHVSLLC--DGFRK------------------------------------- ------------------------------------------------------------ --------------------------------------------QAELLGLQKK------ -------------------------------QLFEHKQILHDHGKMV--RNGIFSNIEFD -S---------------QLLWKISEWSSKKIEAEAGKR--TVLQSPLFYSARFQYKLAVL LLPNGDGKAK-GTHLSIYV--RLCKGEYDALLSWPYRLP---IEISLIDQSQDPRAR--- --INHTYSLRPNPCKENKP---FLGRP------------TSE-S--NPSF-GSQTFMPLD TLNTR---DYIRDDAIFI---RVSVLHDET------------------------------ ------------------------------------------------------------ --------------- >M_mulatta_ENSMMUP00000021907 MYILKERIRASDNQVTMSLLNCENSCGSSQSESDCCVAM-ASSCSAATKDD--S---VGG TA--STGNLSSSFMEDI----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- ------------------------CGHRFCKACIIKSI-------RDAG---HKCPVDNE I----------LLENQ--LFPDNFAKREILSLMVKCPNEG--CLHKMELRHLE------- --------------------------------------------DH--Q-AHCEFALVDC PQ-------CQRPFQKFH----INI----HILKDCPRRQVSCDNCAALVAFEDK-E--IH D------------------------------------------------------QNCPL ANVICEY---CN--TILIREQMPNHYDLDCPTA--PIPCTFSTFGCH---E-K-MQRNHL ARHLQENTQSHMRMLA--QAVHSLSL--------IP------------------------ ------------DSG-------------------------------YVSEVRNFQE---- TIHQLEGRLVRQDHQ--------------------------------IRELTAK------ --------------------METQ-----STYVSELKRTIRTLEDKV--A--EIEAQQCN -G---------------IYIWKIGNFGMHLKCQEEEKP--VVIHSPGFYTGKPGYKLCMR LHLQLPTAQRCANYISLFV--HTMQGEYDSHLPWPFQGT---IRLTILDQSEAP-VR--- --QNHEEIMDAKP---DLL---AFQRP------------TIP-R--NPKGFGYVTFMHLE ALRQR---TFIKDDTLLV---RCEVSTRFDMGSL-------------------------- ---------------------------------RREG--FQPRSTDSGV----------- --------------- >D_rerio_ENSDARP00000036715 --------------------MACNDVDKSSFDDVCCDSG-HSSCAAAMEKERESFLSPTE NP--STISVSSSMPPDQ----------QGYDVEFDPPLESKYECPICLMGLRSAVQT-P- ------------------------CGHRFCDSCIRKSI-------RDTG---QKCPVDNE V----------LLEEQ--LFPDNFAKREILSLTVKCSNFG--CSEKMELRQLE------- --------------------------------------------KH--L-SQCRFATAPC PQ-------CQESVPISH----LDE----HKSQHCLQRIMTCPDCAGSFVYAVK-Q--NH E------------------------------------------------------QFCPF ANTVCEY---CE--MELIRDQLALHCDTDCLKA--PVACTFSTFGCR---E-K-MTRNEL AQHMQEFTQMHMRYMA--EFLRSQTLNNCTM------PSAAAHLSSDDRG---------- -------ASARSPDSCQ-----------------------------CKQELLNLRE---- TVLELEGRLVRQDQQ--------------------------------IRELCIH------ --------------------NDTQ-----KNQVTELRRKLVSLEEST--R--ELEAQQYQ -G---------------IYVWRVENFSHHLRNQEAGQP--IVLHSPPFYTGRPGYKLCLR LHLQTPSAPRCSNFISLFV--HTMQGEFDSQLSWPLQGT---IRLAVLDQV----EG--- --QHHIEVMETKP---DLQ---AFQRP------------TVM-R--NPKGFGYVTFLHLQ ALRQR---GFVKEDVLLV---RCEVTPRFD-ASL-------------------------- ---------------------------------RREG--VQPRGPEPSI----------- --------------- >M_musculus_ENSMUSP00000004949 ----------------MSLLNCENSCGSSQSSSDCCAAM-AASCSAAVKDD--S---VSG SA--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- ------------------------CGHRFCKACIIKSI-------RDAG---HKCPVDNE I----------LLENQ--LFPDNFAKREILSLTVKCPNKG--CLQKMELRHLE------- --------------------------------------------DH--Q-VHCEFALVNC PQ-------CQRPFQKCQ----VNT----HIIEDCPRRQVSCVNCAVSMAYEEK-E--IH D------------------------------------------------------QSCPL ANIICEY---CG--TILIREQMPNHYDLDCPTA--PIPCTFSVFGCH---E-K-MQRNHL ARHLQENTQLHMRLLA--QAVHNVNL-ALRP---CD------------------------ --------AASPSRG-------------------------------CRPEDPNYEE---- TIKQLESRLVRQDHQ--------------------------------IRELTAK------ --------------------METQ-----SMYVGELKRTIRTLEDKV--A--EMEAQQCN -G---------------IYIWKIGNFGMHLKSQEEERP--VVIHSPGFYTGRPGYKLCMR LHLQLPTAQRCANYISLFV--HTMQGEYDSHLPWPFQGT---IRLTILDQSEAL-IR--- --QNHEEVMDAKP---ELL---AFQRP------------TIP-R--NPKGFGYVTFMHLE ALRQG---TFIKDDTLLV---RCEVSTRFDMGGL-------------------------- ---------------------------------RKEG--FQPRSTDAGV----------- --------------- >H_sapiens_ENSP00000316840 ----------------MSLLNCENSCGSSQSESDCCVAM-ASSCSAVTKDD--S---VGG TA--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- ------------------------CGHRFCKACIIKSI-------RDAG---HKCPVDNE I----------LLENQ--LFPDNFAKREILSLMVKCPNEG--CLHKMELRHLE------- --------------------------------------------DH--Q-AHCEFALMDC PQ-------CQRPFQKFH----INI----HILKDCPRRQVSCDNCAASMAFEDK-E--IH D------------------------------------------------------QNCPL ANVICEY---CN--TILIREQMPNHYDLDCPTA--PIPCTFSTFGCH---E-K-MQRNHL ARHLQENTQSHMRMLA--QAVHSLSV--------IP------------------------ ------------DSG-------------------------------YISEVRNFQE---- TIHQLEGRLVRQDHQ--------------------------------IRELTAK------ --------------------METQ-----SMYVSELKRTIRTLEDKV--A--EIEAQQCN -G---------------IYIWKIGNFGMHLKCQEEEKP--VVIHSPGFYTGKPGYKLCMR LHLQLPTAQRCANYISLFV--HTMQGEYDSHLPWPFQGT---IRLTILDQSEAP-VR--- --QNHEEIMDAKP---ELL---AFQRP------------TIP-R--NPKGFGYVTFMHLE ALRQR---TFIKDDTLLV---RCEVSTRFDMGSL-------------------------- ---------------------------------RREG--FQPRSTDAGV----------- --------------- >R_norvegicus_ENSRNOP00000006148 ----------------MSLLNCENSCASSQSSSDCCAAM-ANSCSAAMKDD--S---VSG CV--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- ------------------------CGHRFCKACITKSI-------RDAG---HKCPVDNE I----------LLENQ--LFPDNFAKREILSLTVKCPNKG--CVQKMELRHLE------- --------------------------------------------DH--Q-VHCEFALVIC PQ-------CQRFFQKCQ----INK----HIIEDCPRRQVSCVNCAVPMPYEEK-E--IH D------------------------------------------------------QSCPL ANIICEY---CG--TILIREQMPNHYDLDCPTA--PVPCTFSVFGCH---E-K-MQRNHL ARHLQENTQLHMRLLA--QAVHNVNL-SLRP---CD------------------------ --------ASSPSRG-------------------------------CRPEDPNYEE---- TVKQLEGRLVRQDHQ--------------------------------IRELTAK------ --------------------METQ-----SMHVSELKRTIRSLEDKV--A--EMEAQQCN -G---------------IYIWKIGNFGMHLKSQEEERP--VVIHSPGFYTGRPGYKLCMR LHLQLPTAQRCANYISLFV--HTMQGEYDSHLPWPFQGT---IRLTILDQSEAV-IR--- --QNHEEVMDAKP---ELL---AFQRP------------TIP-R--NPKGFGYVTFMHLE ALRQG---TFIKDDTLLV---RCEVSTRFDMGGL-------------------------- ---------------------------------RKEG--FQPRSTDAGV----------- --------------- >P_pygmaeus_ENSPPYP00000003845 ----------------MSLLNCENSCGSSQSESDCCVAM-ASSCSAATKDD--S---VGG TA--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- ------------------------CGHRFCKACIIKSI-------RDAG---HKCPVDNE I----------LLENQ--LFPDNFAKREILSLMVKCPNEG--CLHKMELRHLE------- --------------------------------------------DH--Q-AHCEFALMDC PQ-------CQRPFQKFH----INI----HILKDCPRRQVSCDNCAASMAFEDK-E--IH D------------------------------------------------------QNCPL ANVICEY---CN--TILIREQMPNHYDLDCPTA--PIPCTFSTFGCH---E-K-MQRNHL ARHLQENTQSHMRMLA--QAVHSLSL--------IP------------------------ ------------DSG-------------------------------YISEVRNFQE---- TIHQLEGRLVRQDHQ--------------------------------IRELTAK------ --------------------METQ-----SMYVSELKRTIRTLEDKV--A--EIEAQQCN -G---------------IYIWKIGNFGMHLKCQEEEKP--VVIHSPGFYTGKPGYKLCMR LHLQLPTAQRCANYISLFV--HTMQGEYDSHLPWPFQGT---IRLTILDQSEAP-VR--- --QNHEEIMDAKP---ELL---AFQRP------------TIP-R--NPKGFGYVTFMHLE ALRQR---TFIKDDTLLV---RCEVSTRFDMGSL-------------------------- ---------------------------------RREG--FQPRSTDAGV----------- --------------- >P_troglodytes_ENSPTRP00000006096 ----------------MSLLNCENSCGSSQSESDCCVAM-ASSCSAATKDD--S---VGG TA--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- ------------------------CGHRFCKACIIKSI-------RDAG---HKCPVDNE I----------LLENQ--LFPDNFAKREILSLMVKCPNEG--CLHKMELRHLE------- --------------------------------------------DH--Q-AHCEFALMDC PQ-------CQRPFQKFH----INI----HILKDCPRRQVSCDNCAASMAFEDK-E--IH D------------------------------------------------------QNCPL ANVICEY---CN--TILIREQMPNHYDLDCPTA--PIPCTFSTFGCH---E-K-MQRNHL ARHLQENTQSHMRMLA--QAVHSLSL--------IP------------------------ ------------DSG-------------------------------YISEVRNFQE---- TIHQLEGRLVRQDHQ--------------------------------IRELTAK------ --------------------METQ-----SMYVSELKRTIRTLEDKV--A--EIEAQQCN -G---------------IYIWKIGNFGMHLKCQEEEKP--VVIHSPGFYTGKPGYKLCMR LHLQLPTAQRCANYISLFV--HTMQGEYDSHLPWPFQGT---IRLTILDQSEAP-VR--- --QNHEEIMDAKP---ELL---AFQRP------------TIP-R--NPKGFGYVTFMHLE ALRQR---TFIKDDTLLV---RCEVSTRFDMGSL-------------------------- ---------------------------------RREG--FQPRSTDAGV----------- --------------- >O_anatinus_ENSOANP00000018657 ----------------MSLLNCENSCGASQSEGDCCAAM-ASACSAGAKDD--S---VSS SV--NTGNLHNSFMAET----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- ------------------------CGHRFCKACIVKSI-------RDAG---HKCPVDNE I----------LLENQ--LFPDNFAKREILSLMVRCPNEG--CLMKMELRQLE------- --------------------------------------------EH--Q-SLCDYALVEC PQ-------CHISFQKNI----LHD----HVVSECPRRQVSCVNCALSMAFEDK-E--YH D------------------------------------------------------QNCPL ASVFCEY---CS--TVLIREQMPTHYDMDCPTA--PIPCTFSSFGCR---E-K-MQRNQL ARHLQDDTQAHMRMMA--QALHSISITALTP---VP---QLDVLPFDPA----------- -------SLPRSSSGY---D--------------------------CHPEVQNFQE---- TIQQLEGRLVRQDHQ--------------------------------IRELIAK------ --------------------METQ-----SSHVVDLKRTIRTLEDKI--A--EMEAQQCN -G---------------IYIWKIGNFGMHLKSQEEEKP--VVIHSPGFYTGKPGYKLCMR LHLQLPNAQRCANYISLFV--HTMQGEYDSHLPWPFQGT---IRLTILDQSEAP-VR--- --QNHEEIMDTKP---ELL---AFQRP------------TIH-R--NPKGFGYVTFMHLQ ALRQR---AFIKDDTLLV---RCEVSTRFDMSSP-------------------------- ---------------------------------RREG--FQPRSTDPGV----------- --------------- >O_cuniculus_ENSOCUP00000010330 ----------------MSLLNCENSCGSGQSESDCCAAM-ASSCSAAAKDD--S---VSG TA--STGNLSGSFVEDI----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- ------------------------CGHRFCKACIIKSI-------RDAG---HKCPVDNE I----------LLENQ--LFPDNFAKREILSLTVKCPNEG--CLHKMELRHLE------- ------------------------------------------XXXX--X-XXXXXXXXXX XX-------XXXXXXXXX----XXX----XXXXXXXXXXXXXXXXXXXXXXXXX-X--IH D------------------------------------------------------QNCPL ANVICEY---CN--TMLIREQMPNHYDLDCPTA--PIPCTFSTFGCH---E-K-MQRNHL ARHLQEKTQLHMRMLA--QAVHSLNL-ALTP---IP------------------------ ------------DSG--------------------------------YPEGHNFQE---- TIQQLEGRLVRQDHQ--------------------------------IRELTAK------ --------------------METQ-----SMYVSELKRTIRTLEDKV--A--EIEAQQCN -G---------------IYIWKIGNFGMHLKSQEEEKP--VVIHSPGFYTGKPGYKLCMR LHLQLPTAQRCANYISLFV--HTMQGEYDSHLPWPFQGT---IRLTILDQSEAP-IR--- --QNHEEIMDAKP---ELL---AFQRP------------TIP-R--NPKGFGYVTFMHLE ALRQR---TFIKDDTLLV---RCEVSTRFDMGSL-------------------------- ---------------------------------RREG--FQPRSTDAGV----------- --------------- >G_gorilla_ENSGGOP00000005734 ----------------MSLLNCENSCGSSQSESDCCVAM-ASSCSAATKDD--S---VGG TA--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- ------------------------CGHRFCKACIIKSI-------RDAG---HKCPVDNE I----------LLENQ--LFPDNFAKREILSLMVKCPNEG--CLHKMELRHLE------- --------------------------------------------XX--X-XXXXXXXXXX XX-------XXXXXXXXX----XXX----XXXXXXXXXXXXXXXXXXXXXXXXX-X--XX X------------------------------------------------------XXXXX XXXXXXX---XX--XXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXX---X-X-MXRNHL ARHLQENTXSXMRMLA--QAVHSLSL--------IX------------------------ ------------XSG-------------------------------YISEVRNFQE---- XIHQLEGRLVRQXHQ--------------------------------IRELTXK------ --------------------METQ-----SMYVSELKRTIRTLEDKV--A--EXEAQQCN -G---------------IYIWKIGNFGMHLKCQEEEKP--VVIHSPGFYTGKPGYKLCMR LHLQLPTAQRCANYISLFV--HTMQGEYDSHLPWPFQGT---IRLTILDQSEAP-VR--- --QNHEEIMDAKP---ELL---AFQRP------------TIP-R--NPKGFGYVTFMHLE ALRQR---TFIKDDTLLV---RCEVSTRFDMGSL-------------------------- ---------------------------------RREG--FQPRSTDAGV----------- --------------- >A_carolinensis_ENSACAP00000005007 ----------------MSLLHSNTSFETNSQESGCCAAM-ASACSAAAKEE--SINASVS NE--TGGTLSNSFMEET----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- ------------------------CGHRFCKACIVKSI-------RDAG---HKCPIDNE I----------LLETQ--LFPDNFAKREILSLTVKCPNKG--CDQKMELRHLE------- --------------------------------------------DH--Q-QHCGFASEKC PQ-------CQGIFQKNR----LQE----HIKLECPRRQVSCPNCALLMPYEDK-E--VH D------------------------------------------------------GVCLL ANVCCEY---CN--TVLIREQLPNHYDNDCPTA--PVPCTYSDFGCP---E-K-MQRNEL ARHWQEFTQVHMRMMA--QTLRNVHVTNPAS---GN---F-------------------- -------HAMPPSCE-------------------------------CSPEVRNFKE---- TIQQLEGRLVRQDHQ--------------------------------IRELIAK------ --------------------METQ-----NSQVGDLKGTIKNLEEKI--T--ELEAQQCN -G---------------IFIWKIEHFSVYLKALEEERP--VVIHSPGFYTGKPGYKLCMR LHIQLPNVQRCANYISLFV--HIMQGEYDNYLPWPFQGT---IRLSVLDQSEGS-PR--- --QNHEEVMDTKP---ELL---AFQRP------------KTR-R--NPKGFGYVTFMQLQ TLRQR---TYIKEDTVLV---RCEVLTRLDVMSP-------------------------- ---------------------------------RREG--FQPRSTDGTV----------- --------------- >T_guttata_ENSTGUP00000010462 ----------------MSLLHSDSSCGGRDAESGCCAAM-ASACSAAAKEE--S---SSV GS--AVGTAPGSFGEET----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- ------------------------CGHRFCKGCIVKSI-------RDAG---HKCPVDNE I----------LLENQ--LFPDNFAKREILSLMVKCPNKG--CSMKMELRHLE------- --------------------------------------------DH--Q-LQCDFSTVEC LQ-------CQGTFPKNH----LKE----HMTQECPRRQVCCPNCATSMAYEDK-E--LH D------------------------------------------------------QTCPL ANIYCEY---CN--TVLIREQMPNHYDNDCPTA--PVPCFYSAFGCP---E-K-MQRNEL ARHMQEFTQVHMRMMA--QSFQNISVTAANP---VP---FINGLPFEPALFS-------- -------HVSHAAYN-------------------------------CNPEVENFKE---- TIQQLEGRLVRQDHQ--------------------------------IRELIAK------ --------------------METQ-----NTHMAELKRTIRNLEGKI--T--EMEAQQCN -G---------------IYIWKIENFSGLQRAQEEERP--VVLHSPGFYTGKPGYKLCLR LHIQLPNAQRCANFISLFV--HTMQGEYDSHLPWPFQGT---IRLSILDQSEGP-ER--- --QNHEEVMEAKP---ELL---AFQRP------------TIH-R--NPKGFGYVTFMHLE TLKQR---TFIKDDTLLV---RCEVLTRLDLSSV-------------------------- ---------------------------------RREG--FQPRSTDGAM----------- --------------- >C_familiaris_ENSCAFP00000010159 ----------------MSLLNCENSCGSSQSESDCCPAM-ASSCSAAVKDD--S---VSG TT--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- ------------------------CGHRFCKACIIKSI-------RDAG---HKCPVDNE I----------LLENQ--LFPDNFAKREILSLMVKCPNEG--CLHKMELRHLE------- --------------------------------------------DH--Q-LHCEFALMNC LQ-------CQRTFQKCQ----LNI----HILKECPRRQVSCMNCAALMAFEDK-E--IH D------------------------------------------------------QNCPL ANVICEY---CN--TMLIREQMPNHYDLDCPTA--PIPCTFSTFGCH---V-K-MQRNHL ARHLQENTQSHMRMLG--QAVQSLSL-ALAP---VP---QRDVPPYDSS----------- -------SVSRVSST-------------------------------CHPEVQNFQE---- TIQQLEGRLVRQDHQ--------------------------------IRELTAK------ --------------------METQ-----SMHVSELKRNIRTLEDKV--A--EIEAQQCN -G---------------IYIWKIGNFGMHLKSQEEEKP--VVIHSPGFYTGKPGYKLCMR LHLQLPTAQRCANYISLFV--HTMQGEYDSHLPWPFQGT---IRLAILDQSEAP-VR--- --QNHEEIMDAKP---ELL---AFQRP------------TIP-R--NPKGFGYVTFMHLE ALRQR---TFIKDDTLLV---RCEVSTRFDMGSP-------------------------- ---------------------------------RREG--FQPRSTDSGI----------- --------------- >X_tropicalis_ENSXETP00000016445 ----------------MSILNCRPSFDGVDTDDACCGAM-ASACCVNTKEDGES---PSA GS--PSGTPQSLVLEDV----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- ------------------------CGHRFCKACILKSI-------RDAG---HKCPVDNE S----------LMENQ--LFPDNFAKREILSLRVKCPSQG--CTETMELRHLE------- --------------------------------------------RH--L-VRCDFAGVEC SQ-------CQSSFPKYS----LQK----HMFEECPRRQIFCENCALAMALEDK-L--NH D------------------------------------------------------QTCPL AYVTCEY---CQ--TNLIREQMPAHYSMDCTMA--PIPCMYYEFGCT---E-K-MQRNDL ARHLQEFTQAHMRMMA--QTLRSFSS-SVTPTSHMPDISFCDPSQFEPAPPSVA------ -----TVHSSHTPSQN---D--------------------------CTQETRNLRE---- TIEQLEGRLVRQDHQ--------------------------------IRELIAK------ --------------------METQ-----CTYVNELKHTIRSLDNRL--G--EMESQQCS -G---------------IFIWRINNFNSLLKNQEEERP--VVIHSQGFYTGKPGYKLCLR LHLQLPSAQRCANYISLFV--HTMQGEYDSLLPWPLQGT---IRLSILDQSEGV-AM--- --QDQEEVMDTKP---ELL---AFQRP------------TVA-R--NPKGFGYVTFMHLQ ALKQR---QYVKNDTLLV---RCSVTTHLDLISP-------------------------- ---------------------------------RREG--FQPRSGDGAL----------- --------------- >B_taurus_ENSBTAP00000021630 ----------------MSLLHCENSCGSSQSESDCCAAMAASSCGTAAKDD--S---VSG TA--STVTLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- ------------------------CGHRFCKACIIKSI-------RDAG---HKCPVDNE I----------LLENQ--LFPDNFAKREILSLMVKCPNEG--CLHKMELRHLE------- --------------------------------------------EH--Q-AHCEFALMSC PQ-------CQRPFQKCH----LNI----HILKECPRRQVPCENCAVSMAFEDK-E--IH E------------------------------------------------------QNCPL ANVICEY---CN--TMLIREQMPNHYDLDCPTA--PVPCTFSAFGCH---E-K-MQRNHL ARHLQENTQSHMRMMA--QAVQTLSL-AVAP---VP---QCTMPLYDSV----------- -------PPTRPSSG-------------------------------RHSEVHNFQE---- TIQQLEGRLVRQDHQ--------------------------------IRELTAK------ --------------------METQ-----SMYVNELKRTIRTLEDKV--A--EIEAQQCN -G---------------IYIWKIGNFGMHLKSQEEEKP--VVIHSPGFYTGKPGYKLCMR LHLQLPSAQRCANYISLFV--HTMQGEYDSHLPWPFQGT---IRLTILDQSEAA-VR--- --QNHEEIMDAKP---ELL---AFQRP------------TIP-R--NPKGFGYVTFMHLE ALRQR---TFIKDDTLLV---RCEVSTRFDMGSL-------------------------- ---------------------------------RREG--FQPRSTDSGI----------- --------------- >E_caballus_ENSECAP00000018618 ----------------MSLLNCENSCGSSQTESDCCAAM-ASSCSAAAKDD--S---VSG TA--STGNLSSSFMEDI----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- ------------------------CGHRFCKACIIKSI-------RDAG---HKCPPD-E I----------LYHP-----ASSLTRRESL-LCPMCPHCM--CYPPSKLYHRS------- --------------------------------------------DH--Q-AHCEFALMNC PQ-------CQHPFQKCQ----LNI----HMLKECPRRQVSCVNCAVSMAFEDK-EASIH D------------------------------------------------------QNCPL ANVICEY---CN--TMLIREQMPNHYDLDCPTA--PIPCTFNTFGCH---E-K-MQRNHL ARHLQENTQSHMRMLA--QAVQSLSL-ALAP---VP---QRDMLPYDSA----------- -------PLSRVSSG-------------------------------CYPEVRNFQE---- TIQQLEGRLVRQDHQ--------------------------------IRELTAK------ --------------------METQ-----SIYVSELKRTIRTLEDKV--A--EIEAQQCN -G---------------IYIWKIGNFGMHLKSQEEEKP--VVIHSPGFYTGKPGYKLCMR LHLQLPTAQRCANYISLFV--HTMQGEYDSHLPWPFQGT---IRLTILDQSEAP-IR--- --QNHEEIMDAKP---ELL---AFQRP------------TIP-R--NPKGFGYVTFMHLE ALRQR---TFIKDDTLLV---RCEVSTRFDMGSL-------------------------- ---------------------------------RREG--FQPRSTDTGV----------- --------------- >G_gallus_ENSGALP00000012873 ----------------MSLLHSDSSCGGRDLDSGCCTAM-ASACSGGAKED--S---VSV GS--GTGNPPSSFTEET----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- ------------------------CGHRFCKGCIVKSI----RRCRDAG---HKCPVDNE I----------LLENQ--LFPDNFAKREILSLTVKCPNKG--CCLKMELRHLE------- --------------------------------------------EH--Q-LHCDFTTVEC PQ-------CQGAFQKNH----LKE----HMTQECPRRQVCCPNCATSMAYEDK-E--LH D------------------------------------------------------QTCPL ANVFCEY---CN--TMLIRQQMPNHYDNDCPTA--PVPCFYSAFGCP---E-K-MQRNEL ARHMQEFTQVHMRMMA--QSIQNISVTATNP---VP---FINGLPFEPALFS-------- -------HVSRAPYN-------------------------------CNPEVENFKE---- TIQQLEGRLVRQDHQ--------------------------------IRELIAK------ --------------------METQ-----NTHMAELKRTIRDLEGKI--T--EMEAQQCN -G---------------IYIWKIENFSGLQKAQEEERP--VVMHSPGFYTGKPGYKLCLR LHIQLPSAQRCANFISLFV--HTMQGEYDSHLPWPFQGT---IRLSILDQSEGP-ER--- --QNHEEVMEAKP---ELL---AFQRP------------TIH-R--NPKGFGYVTFMHLQ TLKQR---TFVKDDTLLV---RCEVLTRLDLNSL-------------------------- ---------------------------------RREG--FQARSTDGAA----------- --------------- >T_nigroviridis_ENSTNIP00000012472 -------MACFDSSSKGSLEEDSCDGAIGGELSGCALVM-MEKEQESLLSP--S---ESP GTYMSGASSSFHDGTHQ----------QGYDVEFDPPLESKYECPICLMALRNAIQT-P- ------------------------CGHRFCKNCIEKSI-------RDAG---QRCPVDNE M----------LSKEQ--LFPDNFAKREILSLIVRCSNPG--CTSKMELRHLE------- --------------------------------------------NH--L-ASCEFATVPC PH-------CQQSVKKTL----LEE----HTSVQCRRRPVSCPDCVEIFVYEEK-E--RH E------------------------------------------------------QQCPF ASVMCPH---CD--MDLTRDQMESHCDTDCPKA--PIACNFSLFGCK---E-R-MQRHDL ARHMQDFTQMHMHYMA--DFLRSLNLNGTIP---KDQGA----------AASAS------ -----SCSKGALSSNCTPCQ--------------------------PTEEMQRLR----- ---EMDRRLVKQDHQ--------------------------------LRELIIL------ --------------------KENQ-----TGQIAELRKRVSVLEESM--R--ELESQHCT -G---------------IYIWRLKDFSVLLRNQEAGLP--VVEHSPGFYTGRPGYKLCLR LHLQSPVAQRCSNFISLFV--HTMQGAYDGLLTWPFQGT---IRLAILDQ--GP-EG--- --QHHIEVMETKP---DLQ---AFQRP------------TII-R--NPKGFGYVTFLHLH HLKER---AYVKDDALLI---RCEVTPRFD-NML-------------------------- ---------------------------------HRDGVTVQPRGSEASI----------- --------------- >T_rubripes_ENSTRUP00000041697 -------MACFD-SSKESL-EDSFDGAAGGKLSGCALAM-SEKERESLLNP--S---ESP STYMSGASSSFQDATHQ----------QGYDVEFDPPLESKYECPICLMALRNAIQT-P- ------------------------CGHRFCKICIEKSI-------RDAG---QRCPVDNE M----------LSKEQ--LFPDNFAKREILSLTVRCSNPG--CTGKMELRHLE------- --------------------------------------------DH--L-AHCQFATVPC PH-------CQQSVRKTI----LEE----HMTAECRRRPVSCPDCIETFVYEER-E--RH E------------------------------------------------------QQCPF ASVMCPY---CD--MDLVRDQMESHCDTDCPIA--PIACTFSLFGCK---E-R-MQRHDL ARHMQDFTQMHMHYMA--DFLRGLNLNGTTP---KPLGAIGHSISFEDHGASAS------ -----SCDKGVSSSNCAPCQ--------------------------PNEETQRLR----- ---EMDRRLVKQDHQ--------------------------------LRELIIL------ --------------------KETQ-----AGQLAELGRRVSMLEETV--R--ELESQHCT -G---------------IFIWRLKDFSVLLRNQEAGLP--VVEHSPAFYTGRPGYKLCLR LHLQSPNAQRCSNFISLFV--HTMQGAFDGRLTWPFQGT---IRLAILDQ--GP-EG--- --QHHVEVMETKP---DLQ---AFQKP------------TII-R--NPKGFGYVTFLHLQ QLNQR---AYVKDDILLI---RCEVTPRFD-NMF-------------------------- ---------------------------------HRDGITVQPRGPEASM----------- --------------- >O_latipes_ENSORLP00000001290 --------------------------ASGGGLSECASAM-LEKERESLPSP--S---DNP TA--SMGSSSLQAAAPL----------QGYDVEFDPPLESKYECPICLMALRNAIQT-R- ------------------------CGHRFCKSCIEKSI-------RDTG---QRCPVDNE M----------LSEDQ--LFPDNFAKREILSLTVRCPNSD--CGEKMELRHLE------- --------------------------------------------KH--L-AQCQFATVPC SQ-------CQQPVRKSY----LEE----HATVECPRRPMSCPDCVAVFVYEER-E--MH E------------------------------------------------------QQCPF ASVMCQY---CE--MDLIRDQMESHCDTDCPKA--PIACTFSIFGCK---E-R-MQRHNL AQHMQEFTQMHMRYMD--IRMTTLTKKTKTT---KNALIVIYFFFPKICVFLVQLQHRLR GSSTRSAASQLILQSC---EFTLYSH----------------SKRLVKNCFYHLR----- NVAKLKPMLTRSDLELIIDSVKCFKAQGFPSLVKCQNILKTPKTQFSLEWVLRH------ --------------------KDRKSNHKLAGQLAELRRRVSVLEETV--K--ELEAQQYH -G---------------IFIWRLKAFSTHLRSQEAGIP--VVEHSPGFYTGRPGYKLCLR LHLQTPTAPRCSNFISLFV--HTMQGVFDSQLTWPFQGT---IRLAILDQ--GP-EG--- --QHHMEVMETKP---DLQ---AFQKP------------INQ-R--NPKGFGYVTFMHRS LLSQR---AYVKDDTLLI---RCEV----------------------------------- ------------------------------------------------------------ --------------- >M_mulatta_ENSMMUP00000022296 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CPNGLYCSV-GTVAQEDLP-HLKDSCSTA--LVLCSFKDSSCK---H-R-CPKWAM AWHVEESVKPHLVMMC-------------------------------------------- ------------------------------------------------------------ -------------------------------------------------ALLIW------ -----------------------------------QWQELQDLQQEL--E--DL-SVGSD -G---------------VLIWKTGSCGQWLQEAKAKPN--LECFSPAFYTQKCGYKLQVS AFLNDKGSGE-GTRLSLYI--DLLPGAFDNLLEWSFAPC---VTFCLLDQSDPGLAK--- -PQHITDTFHPGP---NWK---NFQKP-----GTWEGS-LDE-S--SLGF-GYLKFISHQ DIQKR---KSYSQNCVFVTWGKCFSILKKKFLS--------------------------- ------------------------------------------------------------ --------------- >M_mulatta_ENSMMUP00000021905 -------------------LNCENGCGSSQSESDYCVAM-ASSCSAATKDD--S---VGG TA--SMGNLSSSFMEEI----------QGYDVEFDPPLESRYECPICLTALREAVQT-P- ------------------------CGHRFRKGCIIKSI-------RDAG---HKCPVDDE I----------LLENK--LFPDSFAKREILSLMVNCPNEG--CLHKMELRHLG------- --------------------------------------------DH--Q-AHCEFALMDC PQ-------CQHPFQKFH----INI----HILKDCPRRQVSCDNCAASMAFIKR-S--V- D------------------------------------------------------QNCPL ANVICEY---CN--TILIREQ-ASYYDVDCPTA--PIPCTFRTFDCH---E-K-MQRNHL SHHLQE-TPCHTRMLT--QAVHSLSL--------IP------------------------ ------------DSG-------------------------------YISEARNFQE---- TSHQLEDRLVGQDNQ--------------------------------IQELTDE------ --------------------IETQ-----SIYVSE----IRTLEDKV--A--DIEAQQCN -G---------------IYIWKIGS---HLKCQEEEKP--VVIHSPGFYTGKPGYKLCMR LHLQLLTAQRCANYISLFV--HTMQGEYDSHLPWPF-GT---ICLTILDQSQAP-VR--- --QNHEEIMDAKP---ELL---AFQQP------------TYP----NPKGFGYVTFIHLE ALRQR---TFIKYDTLLV---RCEVSTCFDMGSL-------------------------- ---------------------------------RREG--FQPQSTDAGI----------- --------------- >G_aculeatus_ENSGACP00000022648 -------MASAE-SGKGSLQEDSYEGPVGGELSGCALAM-MEKERESLLSP--S---ESP GTFISGSSASLQAPAPL----------QGYDVEFDPPLESKYECPICLMALRNAIQT-P- ------------------------CGHRFCKNCIEKSI-------RDTG---QRCPVDNE R----------LLEDQ--LFPDNFAKREILSLTVRCPNSD--CADKMELRHLE------- --------------------------------------------NH--L-GRCQFATVPC SQ-------CQQAVRKSR----LEE----HQTAECQKRPVSCPDCVASFFYEER-K--LH Q------------------------------------------------------QRCPF AIVKCLF---CD--LELIRDQIESHCDTDCPKA--PIACNFSAFGCK---E-S-MQRHNL AQHMQEFTQMHMRYMA--EFLRGLSLNGTTP---KSLWAPAPSAYPEDQGATAALAAVCS GP--RGAPSSMSSNSCAPSQ--------------------------PAEGMQRLR----- ---EMDGRLVKQDHQ--------------------------------LRELIIL------ --------------------KETQ-----AGQLAELRRRVSLLEDTV--K--ELESQQCH -G---------------IFIWRLRGFSAHLRNQEAGQP--VVEHSPGFYTGRPGYKLCLR LHLQTPNAPRCSNFISLFV--HTMQGAFDGQLSWPFQGT---IRLAILDQ--GP-EA--- --QHHVEVMETKP---DLQ---AFQKP------------LIQ-R--NPKGFGYVTFLHLH QLTQR---AFVKDDTLLI---RCEVTPRFD-NVL-------------------------- ---------------------------------HRDGPTVQPRGPEASVSRD-------- --------------- >C_elegans_F45G2.6 ------------------------------------------------------------ --------------------------MTSQSVMFKGGLPADCTCPICEQALRDPIKL-N- ------------------------CDHHYCRQCFENEN-------RTPG-----CAACQT I----------IQPEL--CQHDRAKQKQILALPVVCTFESSGCPWDGQLGTLH------- --------------------------------------------DH--L-SECTFKSSLK CE------KCGRQFAKND----LEK----HRA-KCELNRAVCSFCNKTIRDSDR-E--RH P------------------------------------------------------KTCPQ VIISCPF--QCGL-TDRPRLEIEAHCP-SCPNV--DNVCPFVPYGCT---F-A-GGKESI QQHLSDEPVRHLMYLC-------------------------------------------- ------------------------------------------------------------ ---------------------------------------------DEITDLKGT------ --------------------YELM-----ERDMGSFNDRQTRILSAA-----ETCTEMFG -P---------------QLIWKIDKLQQRTNEAKSGAD--TTIFSVPFMSHRFGYKMMAC ACLFGDGSSA-GKSISLYV--LLLKGEFDPTLEWPFHRA---IKISLLDQNPRPEDR--V NITYVIDPRKLKA---NEK---FLARP------------RGE-R--NAAF-GSQSFCSLA ILQ-----NYVKDDKIYV---QIDVDRCETLPVQ-------------------------- ---------------------------------LKSRDAKERKQMLDAMRAKTPDVRLHQ VRPVTSQSSSAELRV >A_gambiae_AGAP000388-PA ------------------------------------------------------------ ----------------------------------------SYLCDIS------------- ------------------------------------------------------------ -----------IIPPS--VYPAQ------------------------------------- --------------------------------------------IH--L-RKCRRQQTVC PN------RCGAIVAKKD----LQL----HSN-TCPKSYG-MESSNEPSNEYDKMQHSLD I----------------------------------------------------------- --------------SGLREQLKVGSTQKKTRFQFFLAPNILTDFL---------SPSRQG TNEWRTDIVNRIDALEKTLFFVNQDRAAIEQEAAVSCLTKQAAALSMGP----------D DGQQPSTSKACQPLALSALN--------------------SAPYHTLPAGSCDSTS---- SSSSMEPVVEVKGPIKEILDDIHKYQVKLNYNQKDITIRLFEC-EERMVELENT------ --------------------LKKC-----RRETYHTKQRTEELQTNMLMANNRGTPASEN -G---------------HVMWRIDNFANRLQQSKELE---TMMKGPIFTNYPYGYMLQLE VSLYGIGTWR-GRNLIAGL--TILPGPYDELLEWPCRLS---ATICVRDQA----AN--- -PAEAVPIYKPIV---AKV---KGQRD------------KNQ----------HYVYVPHD QLYSR---GYVKKDTLFL---EVFVGEEGSDSSEL------------------------- ------------------------------------------------------------ --------------- >D_melanogaster_FBpp0074051 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MSLTKSSSRKDL---------------------- -----------TEQNQYQNQNENQNQPKSTTIVKYEKSSCLFCNEWFDAQTFT------- --------------------------------------------EH--L-IHCGQVLEEC PN------GCQAFIPRIR----MRS----HLK-ECPRNQHNLSNQQRMSVSMDRLDRQSD Q----------------------------------------------------------- --------------RLLVIEQDVGTIRSVLNEEIRQRLHLITDVG-------NIRKQNQV VEDWTRETEKAMDDLR----------RQMEEETNRKAFAIEQNQLDVQYCC---DITQSL KEQVESRLDEAQKLVNQLSAD------VTYHQNQLNDNILKLEELIFENERLNREKFFQI EEFLQQINEDIKTKLG-NSDYVTSKQATLDYEVKNVKNIVCET-EERCDKL--------- -----------------------------DRALHQTMQNISDLETQMAMQQRIASVQNIR -G---------------HLIWRIKDYSKKLEESKQYD---TILHSAMFSNKAFGYALRLD IYLNGKGTWK-GRNMIACL--NVLSGEYDPLLAWPCRLQ---AEIIIRDQC----TN--- -VADAEDYVKT-----------IFVRK------------KSD-D--FIQS-NQYFHIPHK VITSR---NYLRNDSMFI---EVRVLK--------------------------------- ------------------------------------------------------------ --------------- >A_gambiae_AGAP003004-PA ------------------------------------------------------------ -------------------------FLQSAAKADDGVLEARYECPICYCWLNEPILT-K- ------------------------CGHRFCRKCITDWL-------NEKN---SNCPLDNE P----------LDIKCD-IFPDNCTRREISQIKKPCPNSMRGCGEQLSPTDID------- --------------------------------------------TH--L-RQCPFAMSRQ SQ---------------------------------------------------------- ------------------------------------------------------------ -------------------------------------PCPFARVKCK---FVA-PDEAAM SAHIASDCQQHLQVAR--SPCVSALTVTKFEFSPFTICSYCSRRGSNDRYKFWDP----- -----------------------------------------------PAKNSVPEMSTNE LVRSM---------------------------------------YERIVILEQE------ --------------------VHIL-----GIKLSKQEIQLTKLNQ-------EVDPRYSG -G---------------VLLWKLDDFSNKIESMVANSN--CMFYSSEAYTSPHGYKFCAR INVS----PRTKDSIGLHV--HLMQSENDYHLEWPFKGR---IKITLLNVR----SP--- -ELSQHDTIMSKP---EIL---AFHRP------------NQD-I--SPRGFGFLEFAKIK DILA----KFADNNTVVI---KIQMNIV-------------------------------- ------------------------------------------------------------ --------------- >A_aegypti_AAEL011363-PA ------------------------------------------------------------ --------------------------------------------------M--------- ------------------------IFYSFRRNLLIQIP---------------------- -----------HIHNLHLRTTDKITNPILTRLLTPC-----------SFSTFQ------- --------------------------------------------SH--I-ADCGQVLSKC PN------GCGVYVALKD----MDR----HLN-RCPAGFGEAPHQDGD------------ ------------------------------------------------------------ --------------RIRELELEIVGLRSTLNEEIRQRLALITDIG-------QLKKRTQL GDEWTAKVGDVLNALK----------KCINEETDSRCVDVERCKLDINRLMREYERIEAW RLELTTRINRVGELAGRDEVDKPKDAKLVMIESRL--NYLQTEVETLREEQKDRKG---- DEKAQEGNELVKGKIG-VGDEQLDKQAKLDYELKGVLNTVNET-ED---SLEKY------ -----------------------------RRETYYTKQSLDDLQVHLQHQEKLVVIQNTE -G---------------HLIWRIDQFEKRFEESQQSE---FMLKSPLFSNRQFGYTLRME ASLNGIGTWR-GRNMIVGL--VVVNGFYDNLLEWPCVLS---GTITLRDQPE---VR--- -TKPRVDYRRSIV-----------ARR------------KHQ-S--NDK--NQNIHIPHQ VLRSE---HYIRDDAIFL---EVRIDQ--------------------------------- ------------------------------------------------------------ --------------- >D_melanogaster_FBpp0071136 MQRVQADQKPARMHQHAHTHSHAHSLQHAEEKEHNSNEMTTNLSSTGRIAASSSATPSAA AGGGASGAPTPPKSLALNQNHHYAPGSDTSGEQEEELLDSRYECAICIDWLNEPVLT-S- ------------------------CGHRFCRSCLTAWM-------QKNN---QCCPMDNK R----------LSAEHD-IFPDNYTRREIEQLKRDCPNSSLGCSVVASPIELH------- --------------------------------------------RH--L-PSCPYRRQQE PQ---------------------------------------------------------- ------------------------------------------------------------ -----------------------------------EEKCPFAKIKCD---FVGRPETNQL EEHLKADMPHHMQLML--QAFQQTAIATWQPHKPST--SGAAVENGHGQQQLPPP----- ----------------------------------------------PQYANGVDEQ---- IVQTM---------------------------------------YQRIVVLEQR------ --------------------TREQ-----ETRLENMQKQLRLARQQA-----PVDPRYSN -G---------------TIVWRIEQLGALVARLRANAN--NQVYSHECYTSPHGYKFCAR LNIQ----PRKPHVLSLHV--HLMQSENDYHLDWPFKGR---IKLCMVHPA----DA--- -TLSQHDTIMTKP---EIL---AFHKP------------REA-I--STRGFGFLEYANIS NIIQL---GFCADDRLLI---KIEINIV-------------------------------- ------------------------------------------------------------ --------------- >A_aegypti_AAEL015342-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MLYSFRRNLLIQVP---------------------- -----------HIHNLHLRTTDKITNPELTRLLTPC-----------SFPTFQ------- --------------------------------------------SH--I-ADCGQVLSKC PN------GCGVYVALKD----MDR----HLN-RCPAGFGEAPHQDGD------------ ------------------------------------------------------------ --------------RIRELELEIVGLRSTLNEEIRQRLALITDIG-------QLKKRTQL GDEWTAKVGDVLNALK----------KCINEETDSRCVDVERCKLDINRLMREYERIEAW RLELTTRINRVGELAGRDEVDKPKDAKLVMIESRL--NYLQTEVETLREEQKDRKG---- DEKAQEGNELVKGKIG-VGDEQLDKQAKLDYELKGVLNTVNET-EDK--SLEKY------ -----------------------------RRETYYTKQSLDDLQVHLQHQEKLVVIQNTE -G---------------HLIWRIDQFEKRFEESQQSE---FMLKSPLFSNRPFGYTLRME ASLNGIGTWR-GRNMIVGL--VVVNGFYDNLLEWPCVLS---GTITLRDQPQ---DR--- -AKPRVDYRRSIV-----------ARR------------KHQ-S--NDK--NQNIHIPHQ VLRSE---HYIRDDAIFL---EVRIDQ--------------------------------- ------------------------------------------------------------ --------------- >A_carolinensis_ENSACAP00000017602 ------------------------------------------------------------ -----DQDIFDINAALGLDLFEGDIRLDNGRPERNSIIGSQYRWPHTIPYVLEDSLG--- ------------------------MGMIFLKCLCLTKL---------------------- -----------RLPRFHKIEPWQLNTEHIWLTFIFFFSCW-------------------- --------------------------------------------SYVGN-RHTGRQELSI GN------NCDRIATIEHEF--LHALGFWHEQSRSDRDDYVTIMRDRIQAGKESNFNKYD D------------------------------------------------------KTSDF LNVPYDY-------TSVMHYSKTAFMNGTEPTIVTNIPAFIDVIGQR---M-DFSDSDVL KLSRLYNCSSSLSFMGTCSFELANVCGMIQSSNDNADWQRITEISSGPQMDHTYAGVCQE TGYFLHFDTRSGNQG---------------------------DQAILESRFLYPKRGFQC LQFFYYNSGSETDELNIGVKEYTDANPNGTYRL-----------IETIQGLPVN------ -----------------------------YWQLHHISLTMSSKSRVV--FEGIKGSTASN -GGLSIDDVNLSETRCPHHVWHIRNFTELLSSSPLGEA--GSLYSPPFYSPE-GYAFQIA LYVNGSSS---PFNLAIYV--HLISGENDNQLQWPCAWKQ--ITMVLLDQHPDIMQR--- --MSNLRSITTDPNKVESSGLYSWDRPDKVGTEATFPNGTKFMR--GPRS-GTNAFLTHE RLKSR---GFIKDDSIFI---LATVDDISHLISTQPNFTITNAPTTTTVADPCSAYGCKN NGTCIIEAGKPVCRCPVGKDWWYVGEKCDEKGTMQDTAVIAVASSLSVFGVMLIITIITT CCIKKKYKEKMQASR