10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000362994 -------------------------------------------------------------------MASSSGSSPRPAPDENEFPFGCPPTVCQDPKEPRALC---------------- P_troglodytes_ENSPTRP00000036416 -------------------------------------------------------------------MASSSGSSPRPAPDENEFPFGCPPTVCQDPKEPRALC---------------- P_pygmaeus_ENSPPYP00000021917 -------------------------------------------------------------------MASSSGSSPRPAPDENEFPFGCPPTVCQDPKEPRALC---------------- M_mulatta_ENSMMUP00000026496 -------------------------------------------------------------------MASSSGSSPRPAPDENEFPFGCPPTVCRDPKEPRALC---------------- E_caballus_ENSECAP00000009372 -------------------------------------------------------------------MASGSASSPRPAPDENEFPFGCPPTVCEDPSEPRALC---------------- B_taurus_ENSBTAP00000041215 -------------------------------------------------------------------MASGSASSPRPAPDENEFPFGCPPTACQDPPEPGPVC---------------- M_musculus_ENSMUSP00000028234 -------------------------------------------------------------------MASSS------APDENEFQFGCPPAPCQDPSEPRVLC---------------- O_cuniculus_ENSOCUP00000004916 -------------------------------------------------------------------MASSSASSPRPAPDENEFPFGCPPSAFQDPAEPRALC---------------- C_familiaris_ENSCAFP00000031262 -------------------------------------------------------------------MASGSASSPRPAPDENEFPFGCPPDACQEPAEPRAVR---------------- G_gorilla_ENSGGOP00000002249 -------------------------------------------------------------------MASSSGSSPRPAPDENEFPFGCPPTVCQDPKEPRALC---------------- M_domestica_ENSMODP00000024498 -------------------------------------------------------------------LTDTAPVGPHLIPDENEFPFGYPASICQGTPEPKYLCCGCHNVLKKAQQT-L- O_anatinus_ENSOANP00000001757 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006737 -----------------------------------------------------------------------------------------------DVPGHKFLCSNCNNILKKALQT-L- G_gallus_ENSGALP00000002401 ------------------------------------------------------------PRAGPAGGPGADAAVLP----------GGSRRGVGDVPEQKYLCSNCNNVLKKALQT-L- D_rerio_ENSDARP00000091948 -------SGS------------------------------------------------------ASDPSLNGVSSTP----------GFPQSICDEVPKDKYLCSNCNNVLNKARQT-V- T_nigroviridis_ENSTNIP00000011878 --------------------------------------------------------------MARISLDCS--PSLP----------GIPLSVLSVPMENKYKCQQCLQVLRKPVQA-Q- T_rubripes_ENSTRUP00000015632 -------------------------------------------------TDAMA--------TQEPSPPSSMESNKP----------GFPKKILGNKLEDKHLCNCCHNILRRPFQA-Q- D_rerio_ENSDARP00000069217 -------------------------------------------------MISAAGTLCKWKDMERPSLPSSLDSTLP----------GISREVLSVSMEPKYQCQQCKDILRKPFQA-Q- T_rubripes_ENSTRUP00000047803 --------------------------------------------------------------MARISMDCS--SSLP----------GIPLSVLSVPMENKYKCQQCLQVLRKPVQA-Q- O_latipes_ENSORLP00000020860 --------------------------------------------------------------QQEPSPPSSLEGSKP----------GFPRKILANCLEDKHLCNSCEKILRRPLQA-Q- T_rubripes_ENSTRUP00000011363 --------------------------------------------------------------SQEPSPPSSLEGNKP----------GFPKKILANNLENKHLCKSCQKVLRRPLQA-Q- O_latipes_ENSORLP00000003220 ----------------------------------------------------MA--------ALEPSPPSSMESNKP----------GFPKKILGNKLEDKHLCNCCHNILRRPIQA-Q- G_gallus_ENSGALP00000014649 ----------------------------------------------------MA--------AANSTPPGSLDLSQP----------GFAKEILGTKLEVKYLCSDCRNILRRPFQA-Q- C_familiaris_ENSCAFP00000028895 ----------------------------------------------------MA--------AASVTPPGSLDLLQP----------GFSKTLLGTKPEDKYLCSACRNVLRRPFQA-Q- M_domestica_ENSMODP00000021625 ----------------------------------------------------MA--------TANSTPPGSLDLLQP----------GFSKDILGTKLEDKYLCSACKNILRRPFQA-Q- D_rerio_ENSDARP00000043465 --------------------------------------------------------------AQEPSPPSSLEGNKP----------GFPKKILANKLEDKHLCNICLKILRRPFQA-Q- O_latipes_ENSORLP00000008989 --------------------------------------------------------------MARISWDSL--SSLP----------GIPLSVLSVPMEDKYKCQQCLQVLRKPVQA-Q- T_nigroviridis_ENSTNIP00000016461 ----------------------------------------------------MA--------AQEPSPPSSMESNKP----------GFPKKILGNKLEDKHLCNCCHNILRRPFQA-Q- E_caballus_ENSECAP00000011150 ----------------------------------------------------MA--------AASVTPPGSLDLLQP----------GFSKTLLGTKLEDKYLCSACKNVLRRPFQA-Q- T_guttata_ENSTGUP00000002510 ----------------------------------------------------MA--------AANSSPPGSLDLNQP----------GFAKEILGTKLEVKYLCSDCKNILRRPFQA-Q- G_aculeatus_ENSGACP00000022084 --------------------------------------------------------------MARISLDCP--VSLP----------GIPLSVLSVPMENKYKCQQCLLVLRKPVQA-Q- P_pygmaeus_ENSPPYP00000022191 ----------------------------------------------------MA--------AASVTPPGSLELLQP----------GFSKTLLGTKLEAKYLCSACRNVLRRPFQA-Q- M_mulatta_ENSMMUP00000015132 ----------------------------------------------------MA--------AASVTPPGSLELLQP----------GFSKTLLGTKLEAKYLCSACGNVLRRPFQA-Q- P_troglodytes_ENSPTRP00000036949 ----------------------------------------------------MA--------AASVTPPGSLELLQP----------GFSKTLLGTKLEAKYLCSACRNVLRRPFQA-Q- M_musculus_ENSMUSP00000109872 ----------------------------------------------------MA--------AASVTSPGSLELLQP----------GFSKTLLGTRLEAKYLCSACKNILRRPFQA-Q- H_sapiens_ENSP00000247668 ----------------------------------------------------MA--------AASVTPPGSLELLQP----------GFSKTLLGTKLEAKYLCSACRNVLRRPFQA-Q- G_aculeatus_ENSGACP00000006974 ----------------------------------------------------MA--------AQEQSPPSSLEGNKP----------GFPKKILANSLEDKHLCNSCQKVLRRPLQA-Q- T_nigroviridis_ENSTNIP00000013509 ----------------------------------------------------MA--------SQEPSPPSSLEGNKP----------GFPRKILANNLESKHLCKSCQKVLRRPLQA-Q- B_taurus_ENSBTAP00000013869 ----------------------------------------------------MA--------AASVTPPGSLDLLQP----------GFSKTLLGTKLEDKYLCSACKNVLRRPFQA-Q- X_tropicalis_ENSXETP00000042386 -------A--------------------------------------------------------NLSSVPVENEFVF----------GYPTTICDVAPGEKYLCCSCNSVSLNRNHD-L- X_tropicalis_ENSXETP00000008559 ------------------------------------------------------------AAAVSGSPQGSLDLNQP----------GFKKEILGTKLEVKYLCSDCKNLLRRPLQA-Q- G_aculeatus_ENSGACP00000020860 ----------------------------------------------------MA--------TQEPSPPSSMESNKP----------GFPKKILGNQLEDKHLCNCCHNILRRPFQA-Q- G_gorilla_ENSGGOP00000004192 -------MESSK----------------KM---DSPGALQTNPPLKLHT---------------DRSAGTPVFVPEQ----------GGYKEKXXXXXXXXXXXXXXXXXXXXXXXX-X- H_sapiens_ENSP00000376500 -------MESSK----------------KM---DSPGALQTNPPLKLHT---------------DRSAGTPVFVPEQ----------GGYKEKFVKTVEDKYKCEKCHLVLCSPKQT-E- P_troglodytes_ENSPTRP00000011503 -------MESSK----------------KM---DSPGALQTNPPLKLHT---------------DRSAGTPVFVPEQ----------GGYKEKFVKTVEDKYKCEKCHLVLCSPKQT-E- P_pygmaeus_ENSPPYP00000007003 -------MESSK----------------KM---DSPGALQTNPPLKLHT---------------DRSAGTPVFVPEQ----------GGYKEKFVKTVEDKYKCEKCRLVLCSPKQT-E- G_gallus_ENSGALP00000036699 ---------------------------------------------RANP---------------DRSPSASIYVPEQ----------GGYKEKFVNAVEDKYKCEKCHFILCNPKQT-E- R_norvegicus_ENSRNOP00000010906 -------MEPSK----------------KM---GAAGAAQPNPPLKLQP---------------DRG-AASVLVPEQ----------GGYKEKFAKTVEDKYKCEKCRLVLCNPKQT-E- T_guttata_ENSTGUP00000013203 ---------------------------------------------RANP---------------DRSPSASIYVPEQ----------GGYKEKFVNAVEDKYKCEKCHLILCNPKQT-E- O_anatinus_ENSOANP00000023053 -------MDSSK----------------KM---DPS-LVQQNVPPKGNP---------------DRGPGASIYVPEQ----------GGYKERFVKTVEDKYKCEKCHLILCNPKQT-E- B_taurus_ENSBTAP00000017918 -------MEPSK----------------KL---DAAGALPANPPLKLHP---------------ERGAGPAVLVPEQ----------GGYKERFVKAVEDKYKCEKCRLVLCSPKQT-E- C_familiaris_ENSCAFP00000026713 -------MESSK----------------KM---DSPGTLQTNPPLKLHP---------------DRSAGTSIFVPEQ----------GGYKERFVKTVEDKYKCEKCRLVLCNPKQT-E- E_caballus_ENSECAP00000011833 -------MESSK----------------KM---DSPGALQTNPPLKLHP---------------DRSTSTAVFVPEQ----------GGYKERFVKTVEDKYKCEKCRLVLCNPKQT-E- M_musculus_ENSMUSP00000021706 -------MESSK----------------KM---DAAGTLQPNPPLKLQP---------------DRG-AGSVLVPEQ----------GGYKEKFVKTVEDKYKCEKCRLVLCNPKQT-E- X_tropicalis_ENSXETP00000027864 -------MDTGK----------------KT---DPSASV-----QKANP---------------DRSLATTIYVPEQ----------GGYKERFLKPVEEKYKCEKCRLVLCNPRQT-E- M_domestica_ENSMODP00000016701 -------MDSSK----------------KM---DPPNPLQTV-QQKANP---------------DRGAAVSIYVPEQ----------GGYKEKFVKPVEDKYKCEKCHLILCNPKQT-E- A_carolinensis_ENSACAP00000000193 -------MDTSK----------------KT---DPPVSVETV-QQKANV---------------ERSPVPSVYIPEQ----------GGYKEKFVNAVEDKYKCEKCRLILCNPRQT-E- T_rubripes_ENSTRUP00000013348 -------MSAGR----------------STDGREVQIPLQQAAPSLAMPLSVA--------PLLTSHCVPAGFLPLH----------GGFRDHFVEALEAKYCCESCRLVLCQPRQT-E- D_rerio_ENSDARP00000038596 -------MSAGR----------------NV---EQQIPLQQRPPSLAMP------------SMAQRPRPEPGFSPLH----------GGFRDHFVTTPEPKYCCETCRLVLCNPRQT-E- T_nigroviridis_ENSTNIP00000005138 -------PAGG----------------------------------------------------------PAGFQPLH----------GGFRDHFVEAPEAKYCCESCRLVLCQPRQT-E- G_aculeatus_ENSGACP00000005703 -------------------------------GGRCRFPLQQVAPSLTPALSVASPVHRQVNPWPPSDTTPQRFLPLH----------KGFRDHFALTPEAKYCCETCSLVLCQPRQT-E- C_intestinalis_ENSCINP00000003143 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000015940 -------MAYFE----------------EQG-GVPCGFT-------------------------RQNSGNSISLDFE----------PDAEYQFVERLEERYKCAFCHSVLHNPHQT-G- C_intestinalis_ENSCINP00000001432 -------M---------------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000015419 -------MESSK----------------KM---DSPGPLQTNPPLKLHT---------------DRSAGTPIFAPEQ----------GGYKEKFVKTVEDKYKCEKCRLVLCSPKQT-E- M_mulatta_ENSMMUP00000038268 -------MAYSE----------------EHR-GMPCGFI-------------------------RQNSGNSISLDFE----------PNIEYQFVERLEERYKCAFCRSVLHNPHQT-G- P_pygmaeus_ENSPPYP00000000253 -------MAYSE----------------EHK-GMPCGFI-------------------------RQNSGNSISLDFE----------PNIEYQFVERLEERYKCAFCHSVLHNPHQT-G- P_troglodytes_ENSPTRP00000003288 -------MAYSE----------------EHK-GMPCGFI-------------------------RQNSGNSISLDFE----------PNIEYQFVERLEERYKCAFCHSVLHNPHQT-G- E_caballus_ENSECAP00000005414 -------MAYSE----------------EQG-GVPCGFI-------------------------RQNSSNSVSLDFE----------PNTEYRFVEQLEERYKCAFCHSVLHNPHQT-G- C_intestinalis_ENSCINP00000027890 -------M---------------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000017853 -------MAYSE----------------DQG-GVPCGFI-------------------------RQNSSNSISLDFE----------PHTEYRFVEPLEERYKCALCHSVLHNPHQT-G- C_intestinalis_ENSCINP00000001022 -------MDTAD------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000336825 -------MAYSE----------------EHK-GMPCGFI-------------------------RQNSGNSISLDFE----------PSIEYQFVERLEERYKCAFCHSVLHNPHQT-G- O_cuniculus_ENSOCUP00000003184 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000058607 ----------------------------------------------------MA--------AASVTSPGSLELLQP----------GFSKTLLGTRLEAKYLCSACRNILRRPFQA-Q- M_musculus_ENSMUSP00000082710 -------MAHSE----------------EQA-AVPCAFI-------------------------RQNSGNSISLDFE----------PDTEYQFVEQLEERYKCAFCHSVLHNPHQT-G- T_guttata_ENSTGUP00000003276 -------MA-CD----------------EPA-ALSGIFT-------------------------RQNSSSTSSLDFE----------PHADYRFVESLEERYKCAYCHLVLRNPHQT-G- G_gallus_ENSGALP00000016021 -------MA-CD----------------ELT-GVSGIFT-------------------------RQNSASAVSLDFE----------PDTDYKFVETLEDRYKCAYCHSVLHNPHQT-G- C_intestinalis_ENSCINP00000005981 -------M---------------------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000025605 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000017068 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000013484 -------SMGSE----------------ELT-IGSRAFS-------------------------HQNSSSCISLDFE----------PDIQYQFVEQLEERYKCTFCHSVLHNPHQT-S- A_carolinensis_ENSACAP00000016112 -------MASED----------------LAC-QVPNFYI-------------------------RQNSTNAVSLDFE----------PDASYQFVEILEDRYKCTHCHLVLHNPHQT-G- M_domestica_ENSMODP00000003305 -------SLTSA----------------EYG-SASGDFL-------------------------PQNSSSYISLDFE----------PNIDYQFVEQLEERYKCASCHSVLHNPHQT-G- O_cuniculus_ENSOCUP00000007884 -------MAYSE----------------EPG-GIHLGFI-------------------------RQNSGSSISLDFE----------PNAEYRFVEQLEERYKCAFCHSVLHNPHQT-G- A_carolinensis_ENSACAP00000010321 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000031605 -------IMACE----------------DLC-PLPVTLG-------------------------RQNSSAAVSLDFV----------PKQEYLFVEQLQDRYKCASCHLVLHNPHQT-G- G_gorilla_ENSGGOP00000006994 ----------------------------------------------------MA--------AASVTPPGSLELLQP----------GFSKTLLGTKLEAKYLCSACRNVLRRPFQA-Q- O_latipes_ENSORLP00000001368 ---------------------------------------------------------------------LAGRLQTH----------GVVRNHFVMKLKEEFICPICKGVVLNPQQN-S- G_aculeatus_ENSGACP00000025883 --------------------------------------------------------------------------------------------KFVSPLREEFVCPVCGGVVLNPQQN-S- D_rerio_ENSDARP00000014326 -------------------------------------------------------------------------------------------------LEQQFICPSCGGIVLNPHQT-G- C_intestinalis_ENSCINP00000027041 -----------------------------------------------------------------------------------------------------------MPINTNPWMR--- P_troglodytes_ENSPTRP00000015252 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000009119 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000028200 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000016271 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000262395 --------------------------------------------------------------------------------------MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVST- T_nigroviridis_ENSTNIP00000019321 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000016344 --------------------------------------------------------------------------------------MPGFDYKFLEKPKRRLLCPLCGKPMREPVXXPP- E_caballus_ENSECAP00000009502 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000013849 --------------------------------------------------------------------------------------MPGFDYKFLEKPKRRFQCPLCSKAMREPVQVST- B_taurus_ENSBTAP00000050075 --------------------------------------------------------------------------------------MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVST- M_musculus_ENSMUSP00000017530 --------------------------------------------------------------------------------------MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVST- G_aculeatus_ENSGACP00000014759 --------------------------------------------------------------------------------------MPGFDYKFLEKPKRRFQCPLCSKAMREPVQVST- R_norvegicus_ENSRNOP00000018468 --------------------------------------------------------------------------------------MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVST- T_rubripes_ENSTRUP00000012878 --------------------------------------------------------------------------------------MPGFDYKFLEKPKRRFQCPLCSKAMREPVQVST- O_latipes_ENSORLP00000005579 --------------------------------------------------------------------------------------MPGFDYKFLEKPKRRFQCPLCSKAMREPVQVST- M_domestica_ENSMODP00000024090 --------------------------------------------------------------------------------------MPGFDYKFLEKPKRRLLCPLCAKAMREPVQVST- X_tropicalis_ENSXETP00000056667 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010017-PA -------M-----------------------------------------------------------------------------------VRSLSQWTKTLSFPARISPNRNSKDC-NV A_aegypti_AAEL006649-PA -------M-----------------------------------------------------------------------------------VRSLSQWTKTLSFPARISPNRNSKEC-SV D_rerio_ENSDARP00000056877 --------------------------------------------------------------------------------------MPGLDLKFLERPRRKFYCPLCEKPMREPVQVST- D_melanogaster_FBpp0111838 -------MPAPPATVKPATGHTTKLNNGKSSNSNSNHTLSNSIAHLSDSRTNLTVNTPTTCQRLSEMFRRSIASSTQ----------SSSRENTYEEWTKTLSFPSRLSPNRNSKDC-ST O_anatinus_ENSOANP00000019424 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000024756 ----------------MSLLNCEDSCGTSHPESDCCAGV-ASACSTGTKDD--S---VNGST--IPGNLPSSLREEI----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- C_intestinalis_ENSCINP00000003738 -------------------------------------------------------------------------------------------------------CVECKYTLEFPVALSN- M_mulatta_ENSMMUP00000021907 MYILKERIRASDNQVTMSLLNCENSCGSSQSESDCCVAM-ASSCSAATKDD--S---VGGTA--STGNLSSSFMEDI----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- D_rerio_ENSDARP00000036715 --------------------MACNDVDKSSFDDVCCDSG-HSSCAAAMEKERESFLSPTENP--STISVSSSMPPDQ----------QGYDVEFDPPLESKYECPICLMGLRSAVQT-P- M_musculus_ENSMUSP00000004949 ----------------MSLLNCENSCGSSQSSSDCCAAM-AASCSAAVKDD--S---VSGSA--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- H_sapiens_ENSP00000316840 ----------------MSLLNCENSCGSSQSESDCCVAM-ASSCSAVTKDD--S---VGGTA--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- R_norvegicus_ENSRNOP00000006148 ----------------MSLLNCENSCASSQSSSDCCAAM-ANSCSAAMKDD--S---VSGCV--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- P_pygmaeus_ENSPPYP00000003845 ----------------MSLLNCENSCGSSQSESDCCVAM-ASSCSAATKDD--S---VGGTA--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- P_troglodytes_ENSPTRP00000006096 ----------------MSLLNCENSCGSSQSESDCCVAM-ASSCSAATKDD--S---VGGTA--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- O_anatinus_ENSOANP00000018657 ----------------MSLLNCENSCGASQSEGDCCAAM-ASACSAGAKDD--S---VSSSV--NTGNLHNSFMAET----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- O_cuniculus_ENSOCUP00000010330 ----------------MSLLNCENSCGSGQSESDCCAAM-ASSCSAAAKDD--S---VSGTA--STGNLSGSFVEDI----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- G_gorilla_ENSGGOP00000005734 ----------------MSLLNCENSCGSSQSESDCCVAM-ASSCSAATKDD--S---VGGTA--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- A_carolinensis_ENSACAP00000005007 ----------------MSLLHSNTSFETNSQESGCCAAM-ASACSAAAKEE--SINASVSNE--TGGTLSNSFMEET----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- T_guttata_ENSTGUP00000010462 ----------------MSLLHSDSSCGGRDAESGCCAAM-ASACSAAAKEE--S---SSVGS--AVGTAPGSFGEET----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- C_familiaris_ENSCAFP00000010159 ----------------MSLLNCENSCGSSQSESDCCPAM-ASSCSAAVKDD--S---VSGTT--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- X_tropicalis_ENSXETP00000016445 ----------------MSILNCRPSFDGVDTDDACCGAM-ASACCVNTKEDGES---PSAGS--PSGTPQSLVLEDV----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- B_taurus_ENSBTAP00000021630 ----------------MSLLHCENSCGSSQSESDCCAAMAASSCGTAAKDD--S---VSGTA--STVTLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- E_caballus_ENSECAP00000018618 ----------------MSLLNCENSCGSSQTESDCCAAM-ASSCSAAAKDD--S---VSGTA--STGNLSSSFMEDI----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- G_gallus_ENSGALP00000012873 ----------------MSLLHSDSSCGGRDLDSGCCTAM-ASACSGGAKED--S---VSVGS--GTGNPPSSFTEET----------QGYDVEFDPPLESKYECPICLMALREAVQT-P- T_nigroviridis_ENSTNIP00000012472 -------MACFDSSSKGSLEEDSCDGAIGGELSGCALVM-MEKEQESLLSP--S---ESPGTYMSGASSSFHDGTHQ----------QGYDVEFDPPLESKYECPICLMALRNAIQT-P- T_rubripes_ENSTRUP00000041697 -------MACFD-SSKESL-EDSFDGAAGGKLSGCALAM-SEKERESLLNP--S---ESPSTYMSGASSSFQDATHQ----------QGYDVEFDPPLESKYECPICLMALRNAIQT-P- O_latipes_ENSORLP00000001290 --------------------------ASGGGLSECASAM-LEKERESLPSP--S---DNPTA--SMGSSSLQAAAPL----------QGYDVEFDPPLESKYECPICLMALRNAIQT-R- M_mulatta_ENSMMUP00000022296 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021905 -------------------LNCENGCGSSQSESDYCVAM-ASSCSAATKDD--S---VGGTA--SMGNLSSSFMEEI----------QGYDVEFDPPLESRYECPICLTALREAVQT-P- G_aculeatus_ENSGACP00000022648 -------MASAE-SGKGSLQEDSYEGPVGGELSGCALAM-MEKERESLLSP--S---ESPGTFISGSSASLQAPAPL----------QGYDVEFDPPLESKYECPICLMALRNAIQT-P- C_elegans_F45G2.6 --------------------------------------------------------------------------------------MTSQSVMFKGGLPADCTCPICEQALRDPIKL-N- A_gambiae_AGAP000388-PA ----------------------------------------------------------------------------------------------------SYLCDIS------------- D_melanogaster_FBpp0074051 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP003004-PA -------------------------------------------------------------------------------------FLQSAAKADDGVLEARYECPICYCWLNEPILT-K- A_aegypti_AAEL011363-PA --------------------------------------------------------------------------------------------------------------M--------- D_melanogaster_FBpp0071136 MQRVQADQKPARMHQHAHTHSHAHSLQHAEEKEHNSNEMTTNLSSTGRIAASSSATPSAAAGGGASGAPTPPKSLALNQNHHYAPGSDTSGEQEEELLDSRYECAICIDWLNEPVLT-S- A_aegypti_AAEL015342-PA ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000017602 -----------------------------------------------------------------DQDIFDINAALGLDLFEGDIRLDNGRPERNSIIGSQYRWPHTIPYVLEDSLG--- 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000362994 -----------------------------CAGCLSENP-------RNGE--DQICPKCRGEDLQSISPGSRLRTQE-------------------------------------------- P_troglodytes_ENSPTRP00000036416 -----------------------------CAGCLSENP-------RNGE--DQICPKCRGEDLQSISPGSRLRTQE-------------------------------------------- P_pygmaeus_ENSPPYP00000021917 -----------------------------CTGCLSENP-------RNGE--DQICSKCRGEDLQSISPGSRLRTQE-------------------------------------------- M_mulatta_ENSMMUP00000026496 -----------------------------CTGCLSENL-------RNSE--DQICPKCRGEDLQSVSPGSRLRTLE-------------------------------------------- E_caballus_ENSECAP00000009372 -----------------------------CAACLSENS-------RNGE--DRVCLKCRGDDSQSVGPGS-LVSQE-------------------------------------------- B_taurus_ENSBTAP00000041215 -----------------------------CAVCLSEKV-------RNDE--DRICPKCKGDDTPSESPGS-LLSQE-------------------------------------------- M_musculus_ENSMUSP00000028234 -----------------------------CTACLSENL-------RDDE--DRICPKCRADNLHPVSPGS-PLTQE-------------------------------------------- O_cuniculus_ENSOCUP00000004916 -----------------------------CTACLSE-L-------RNCE--DRICPACKGDNPTSVSPGS-LRTQE-------------------------------------------- C_familiaris_ENSCAFP00000031262 -----------------------------CAACLPENV-------RSGE--DRICPKCQGDDPQSGSPGS-PLSQE-------------------------------------------- G_gorilla_ENSGGOP00000002249 -----------------------------CAGCLSENP-------RNGE--DQICPKCRGEDLQSISPGSRLRTQE-------------------------------------------- M_domestica_ENSMODP00000024498 ------------------------CGHRYCAACLSWIL-------------------------SSPNDGT-LFFWG--FFQNSL------------------------------------ O_anatinus_ENSOANP00000001757 ------------------------------------------------------------------------------AFSDAAINKEISELNVHCVTPG--CSWTGLMKNFE------- T_guttata_ENSTGUP00000006737 ------------------------CGHRYCSACLAWIL-------RNNK--NAICQKCKEEDPNTLGEESLLAEER--AFGDAAINKEISELRVHCVTLG--CSWSGIMKDFE------- G_gallus_ENSGALP00000002401 ------------------------CGHRYCSACLSWIV-------RNNK--NPVCQKCKEEDPSTLSEGSLLAEER--AFGDAAINKEISELRVHCVTLG--CSWCGTMKNFE------- D_rerio_ENSDARP00000091948 ------------------------CGHRYCLACVNWLV-------RNNK--DLVCTKCKGEDSNVESDTSVLTPNQ--FFNDVAINKEILDLKVHCANQG--CPWRSTLKNFE------- T_nigroviridis_ENSTNIP00000011878 ------------------------CGHRFCVHCFRELT-------SSGP---KPCEACRQEEIYEEPTSI-LNSNE--VFPDNAAGREIASLPARCLNQD--CSWTGSIKQYE------- T_rubripes_ENSTRUP00000015632 ------------------------CGHRFCSYCFNRTV-------SNGP---QKCSACIKRILWFQ------------AFPDNAVRREVEHLPAACINEN--CTWKGTIKEYE------- D_rerio_ENSDARP00000069217 ------------------------CGHRFCVFCFKQLT-------SSGP---IPCEACRAEGIFEEETSV-LNIAV--AFPDNAARREIDSLPAKCPNEG--CSWSGTLKDFE------- T_rubripes_ENSTRUP00000047803 ------------------------CGHRFCIHCFKELT-------SSGP---KPCEACRQEEIYEEPISV-LNSNE--VFPDNAAGREIASLPARCLNQG--CSWTGSIKQYE------- O_latipes_ENSORLP00000020860 ------------------------CGHRFCCFCFNRTV-------SSGP---QKCSACIKEDLFEEPTSI-LKQGG--AFHDNAARREVEALAAVCPNEG--CTWTGTVKEYE------- T_rubripes_ENSTRUP00000011363 ------------------------CGHRFCSFCFHKIV-------SAGP---QTCSACISEDLFEEPASI-LKLGG--AFPDNAARREVEALAAVCPNEG--CIWTGTIKEFE------- O_latipes_ENSORLP00000003220 ------------------------CGHRFCSYCFNRTV-------SNGP---QKCNACIKEEIFEEPTSI-LKQGC--AFPDNAVRREVEGLSADCINEN--CPWKGTIKEYE------- G_gallus_ENSGALP00000014649 ------------------------CGHRYCSYCLKKII-------SSGP---QKCASCIQEGIYEEGISI-LETSS--AFPDNAARREVESLPAVCINEG--CTWKGTIKEYE------- C_familiaris_ENSCAFP00000028895 ------------------------CGHRYCSYCLSSIL-------SSGP---QNCAACVHEGIYEEGISI-LESSS--AFPDNAARREVESLPAVCPNNG--CTWKGTLKEYE------- M_domestica_ENSMODP00000021625 ------------------------CGHRYCSYCLTSII-------STGP---QNCAACIQEGIYEEGISI-LESSS--AFPDNAARREVESLPAVCVNDG--CTWKGTIKEYE------- D_rerio_ENSDARP00000043465 ------------------------CGHRFCSYCFNKAV-------SKDK---KVCTTVV---------IM-KKKKK--AFPDNAAKREVEALEAVCINEE--CSWTGTIKEYE------- O_latipes_ENSORLP00000008989 ------------------------CGHRFCVHCFRQLT-------SSGP---KPCQACRKEEIYEEPMSI-LNSSE--AFPDNAAGREIASLPARCLNQG--CDWTGSIKEYE------- T_nigroviridis_ENSTNIP00000016461 ------------------------CGHRFCSYCFTRTV-------SNGP---QKCSACIKEDIFEDPTSI-LKQGC--AFPDNAVRREVEHLPAVCINEN--CTWKGTIKEYE------- E_caballus_ENSECAP00000011150 ------------------------CGHRYCSYCLTSIL-------SSGP---QNCAACVHEGIYEEGISI-LESSS--AFPDNAARREVESLPAVCPSDG--CTWKGTLKEYE------- T_guttata_ENSTGUP00000002510 ------------------------CGHRYCSYCLKKII-------SAGP---QKCASCIQEGIYEEGISI-LETSS--AFPDNAARREVESLPAVCINSG--CNWKGTIKEYE------- G_aculeatus_ENSGACP00000022084 ------------------------CGHRFCVHCFRQLT-------SYGP---KPCDACRQEEIYEEPISI-LNSNE--AFPDNAAGREIASLPAKCLNQG--CDWTGSIKEYE------- P_pygmaeus_ENSPPYP00000022191 ------------------------CGHRYCSFCLASIL-------SSGP---QNCAACVHEGIYEEGISI-LESSS--AFPDNAARREVESLPAVCPSDG--CTWKGTLKEYE------- M_mulatta_ENSMMUP00000015132 ------------------------CGHRYCSFCLASIL-------SSGP---QNCAACVHEGIYEEGISI-LESSS--AFPDNAARREVESLPAVCPIDG--CTWKGTLKEYEVKMPVCG P_troglodytes_ENSPTRP00000036949 ------------------------CGHRYCSFCLASIL-------SSGP---QNCAACVHEGIYEEGISI-LESSS--AFPDNAARREVESLPAVCPSDG--CTWKGTLKEYE------- M_musculus_ENSMUSP00000109872 ------------------------CGHRYCSFCLTSILRCASILSSSGP---QNCAACVYEGLYEEGISI-LESSS--AFPDNAARREVESLPAVCPNDG--CTWKGTLKEYE------- H_sapiens_ENSP00000247668 ------------------------CGHRYCSFCLASIL-------SSGP---QNCAACVHEGIYEEGISI-LESSS--AFPDNAARREVESLPAVCPSDG--CTWKGTLKEYE------- G_aculeatus_ENSGACP00000006974 ------------------------CGHRFCSFCFNKIV-------SSGP---QKCSACIKEDLFEDPTSI-LKQGG--AFPDNAARREVEALAAVCPNEE--CTWTGTIKEFE------- T_nigroviridis_ENSTNIP00000013509 ------------------------CGHRFCCFCFRKIV-------SAGP---QTCRACISEDLFEEPASI-LKSGG--AFPDNAARREVEALAAVCPNEG--CTWTGTIKEFE------- B_taurus_ENSBTAP00000013869 ------------------------CGHRYCSFCLSSIL-------SSGP---QSCAACVHEGIYEEGVSI-LESSS--AFPDNAARREVESLPAVCPSEG--CSWKGTLKDYE------- X_tropicalis_ENSXETP00000042386 ------------------------------------------------------CPKCKAEDPT--------------TLSDDSLLKE-------------------------------- X_tropicalis_ENSXETP00000008559 ------------------------CGHRYCSHCLNKII-------STGP---QKCSACIQEGIWHQTVCI-VSDWG--GQPGNV--RGVGGGSSVILGGGMYCVLNPTHQSGR------- G_aculeatus_ENSGACP00000020860 ------------------------CGHRFCSYCFNRTV-------SNGP---QKCSACIKEDLFEDPTSI-LKPGC--AFPDNAVRREVENLSAVCIHEH--CSWKGSIKDYE------- G_gorilla_ENSGGOP00000004192 ------------------------XXXXXXXXXXXXXX-------X-XX--XXXXXXXXXS----------IVKDK--VFKDNCCKREILALQIYCRNESRGCAEQLTLGHLL------- H_sapiens_ENSP00000376500 ------------------------CGHRFCESCMAALL-------S-SS--SPKCTACQES----------IVKDK--VFKDNCCKREILALQIYCRNESRGCAEQLMLGHLL------- P_troglodytes_ENSPTRP00000011503 ------------------------CGHRFCESCMAALL-------S-SS--SPKCTACQES----------IVKDK--VFKDNCCKREILALQIYCRNESRGCAEQLTLGHLL------- P_pygmaeus_ENSPPYP00000007003 ------------------------CGHRFCESCMAALL-------S-SS--SPKCTACQES----------IVKDK--VFKDNCCKREILALQIYCRNESRGCAEQLTLGHLL------- G_gallus_ENSGALP00000036699 ------------------------CGHRFCETCMNALL-------S-TP--SPKCTACQES----------IVKDK--VFKDNCCRRELLALQIYCRNENKGCKEQLSLGQLL------- R_norvegicus_ENSRNOP00000010906 ------------------------CGHRFCESCMAALL-------S-SS--SPKCTACQES----------IIKDK--VFKDNCCKREILALQIYCRNEGRGCVEQLTLGHLL------- T_guttata_ENSTGUP00000013203 ------------------------CGHRFCETCMNALL-------R-SS--SPKCTACQES----------IVKDK--VFKDNCCRRELLALQIYCRNENKGCKEQLSLGQLL------- O_anatinus_ENSOANP00000023053 ------------------------CGHRFCETCMNMLL-------S-SS--SPKCSACQEN----------VIKDK--VFKDNCCKREILALQIYCRNENRGCTEQLTLGHLL------- B_taurus_ENSBTAP00000017918 ------------------------CGHRFCETCMGALL-------S-SS--SPKCTACQEV----------IIKDK--VFKDNCCKREILALQIFCRNEGRGCTEQLALGHLL------- C_familiaris_ENSCAFP00000026713 ------------------------CGHRFCETCMAAVL-------S-SS--SPKCTACQES----------IIKDK--VFKDNCCKREILALQIYCRNEGGGCTEQLTLGHLL------- E_caballus_ENSECAP00000011833 ------------------------CGHRFCETCMAALL-------S-SS--SPKCTACQEG----------IIKDK--VFKDNCCKREILALQIYCRNESRGCVEQLTLGHLL------- M_musculus_ENSMUSP00000021706 ------------------------CGHRFCESCMAALL-------S-SS--SPKCTACQES----------IIKDK--VFKDNCCKREILALQVYCRNEGRGCAEQLTLGHLL------- X_tropicalis_ENSXETP00000027864 ------------------------CGHRFCETCMNAIL-------S-ST--SPQCMACEDN----------ITKDK--VFKDNCCRREVLALQMFCRNETRGCKELITLGNLL------- M_domestica_ENSMODP00000016701 ------------------------CGHRFCETCMHVLL-------S-AP--SPKCTACQEN----------IIKDK--VFKDNCCKREILALQIYCRNESRGCTEQLTLGHLL------- A_carolinensis_ENSACAP00000000193 ------------------------CGHRYCETCMNALL-------S-CT--IPKCTACQET----------IVKEK--IFKDNCCRRELLALQIFCRNENKGCREQLTLGQLL------- T_rubripes_ENSTRUP00000013348 ------------------------CGHRFCQSCINDIL-------S-HP--NPVCPADTEP----------LFKDK--VFRDVCCHREIMALKVYCRSEANGCQEQMRLQQIP------- D_rerio_ENSDARP00000038596 ------------------------CGHRFCESCINELL-------S-KP--NPVCPADLLP----------LFEDK--IFRDVCCNREIMALKVYCRSEKNGCKEQMCLQQVM------- T_nigroviridis_ENSTNIP00000005138 ------------------------CGHRFCQSCITQLL-------G-HA--NPVCPADMEP----------LFKDK--IFRDVCCHREIMALKVYCRSEANGCQEQMRLQQIP------- G_aculeatus_ENSGACP00000005703 ------------------------CGHRFCQSCINDIL-------S-HP--NPVCPADMEP----------LFKDK--IFRDVCCHREIMALKVYCRSEANGCQEQMSLQQIP------- C_intestinalis_ENSCINP00000003143 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000015940 ------------------------CGHRFCHQCILALR-------ELDT--VPLCPVDKEV----------IKSQE--VFKDNCCKREVLNLYVFCKN-APRCNAKIILGRYQ------- C_intestinalis_ENSCINP00000001432 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000015419 ------------------------CGHRFCESCMAALL-------S-SS--SPKCTACQES----------VVRDK--VFKDNCCKREILALQIYCRNESRGCAEQLTLGHLL------- M_mulatta_ENSMMUP00000038268 ------------------------CGHRFCQHCILSLR-------ELNT--VPICPVDKEV----------IKSQE--VFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQ------- P_pygmaeus_ENSPPYP00000000253 ------------------------CGHRFCQHCILSLR-------ELNT--VPICPVDKEV----------IKSQE--VFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQ------- P_troglodytes_ENSPTRP00000003288 ------------------------CGHRFCQHCILSLR-------ELNT--VPICPVDKEV----------IKSQE--VFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQ------- E_caballus_ENSECAP00000005414 ------------------------CGHRFCQHCILSLR-------ELNA--VPLCPVDKEV----------IKSQE--VFKDNCCKREVLNLYVYCKN-APGCNAKIILGRYQ------- C_intestinalis_ENSCINP00000027890 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000017853 ------------------------CGHRFCQHCILSLR-------ELNA--VPLCPVDKEV----------IKSQE--VFKDNCCKREVLNLYVYCKN-APGCNAKIILGRYQ------- C_intestinalis_ENSCINP00000001022 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000336825 ------------------------CGHRFCQHCILSLR-------ELNT--VPICPVDKEV----------IKSQE--VFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQ------- O_cuniculus_ENSOCUP00000003184 -----------------------------------------------SS--SPKCTACQES----------IVKDK--VFKDNCCKREILALQICCRNESRGCAEQLALGHLL------- R_norvegicus_ENSRNOP00000058607 ------------------------CGHRYCSFCLTSILRSQSAHSSSGP---QNCAACVHEGLYEEGISI-LESSS--AFPDNAARREVESLPAVCPNDG--CTWKGTLKEYE------- M_musculus_ENSMUSP00000082710 ------------------------CGHRFCQQCIRSLR-------ELNS--VPICPVDKEV----------IKPQE--VFKDNCCKREVLNLHVYCKN-APGCNARIILGRFQ------- T_guttata_ENSTGUP00000003276 ------------------------CGHRFCQQCILALR-------ELNA--VPTCPVDKET----------IKMHE--VFKDNCCKREVLNLHVFCKN-FPDCSSKVILGRYQ------- G_gallus_ENSGALP00000016021 ------------------------CGHRFCQQCILTLR-------GLNA--VPTCPVDKET----------IKMHE--VFKDNCCKREVLNLYVFCKN-LPDCNSKIILGRYQ------- C_intestinalis_ENSCINP00000005981 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000025605 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000017068 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000013484 ------------------------CGHRFCQHCILSLR-------ELNN--FPTCPIDKKI----------IQLQE--VFKDNCCKREVLNLQVFCKN-APGCNSKMILGRYQ------- A_carolinensis_ENSACAP00000016112 ------------------------CGHRFCQRCIASLR-------ELSV--IPTCPVDKEI----------IKPHE--VFKDNCCKREVLNLQVYCRN-SPACNAKTSLGRYQ------- M_domestica_ENSMODP00000003305 ------------------------CGHRFCENCILSLR-------ELNT--VSICPVDKEI----------IKPKE--VFKDNCCKREVLNLQVFCKN-APHCAAKMILGRYQ------- O_cuniculus_ENSOCUP00000007884 ------------------------CGHRFCQHCILSLR-------ELNT--VPICPVDKEV----------IRSQE--VFKDNCCKREVLNLHVYCKN-APGCNAKVILGRYQ------- A_carolinensis_ENSACAP00000010321 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000031605 ------------------------CGHRFCEKCISNLI-------ELSE--TPQCPIDMEN----------IKSHE--IFKDNCCKREVLNLLVYCKN-SPACDVKVMLGRYQ------- G_gorilla_ENSGGOP00000006994 ------------------------CGHRYCSFCLASIL-------SSGP---QNCAACVHEGIYEEGISI-LESSS--XXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXX------- O_latipes_ENSORLP00000001368 ------------------------CGHIYCFHCLQGLL-------ESSLLSGPVCPVEKAA----------ITPSE--VFQDNCCKREISSLEVYCTN-SPLCTSVLALNQLQ------- G_aculeatus_ENSGACP00000025883 ------------------------CGHIFCFLCLRALR-------ESSPASGPVCPVDGAA----------ITPAG--VFQDNCCKREISGLEVYCVN-FPACASVVTLRRLQ------- D_rerio_ENSDARP00000014326 ------------------------CGHIFCAQCVKAYT-------ENGG--SSKCPLDSIP----------IKPEE--IFQDNCCKRELLNLEVFCTN-APECTQRFSLCNLQ------- C_intestinalis_ENSCINP00000027041 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000015252 -------------------------------------L-------SEGV---FKCPEDQLP----------LDYAK--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ------- P_pygmaeus_ENSPPYP00000009119 ----------------------------------------------EGV---FKCPEDQLP----------LDYAK--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ------- M_mulatta_ENSMMUP00000028200 ---------------------------------------------SEGV---FKCPEDQLP----------LDYAK--IYPDPELEVQVLGLPIRCIHSEEGCRWNGPLRHLQ------- B_taurus_ENSBTAP00000016271 ---------------------------------------------------------------------------Q--IYPDPELEVQVLGLSIRCIHSEEGCRWNGPLRHLQ------- H_sapiens_ENSP00000262395 ------------------------CGHRFCDTCLQEFL-------SEGV---FKCPEDQLP----------LDYAK--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ------- T_nigroviridis_ENSTNIP00000019321 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000016344 ------------------------CGHRFCDTCLQEFL-------SEGV---FKCPEDQLP----------LDYAK--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX------- E_caballus_ENSECAP00000009502 ---------------------------------------------SEGV---FKCPEDQLP----------LDYAK--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ------- D_rerio_ENSDARP00000013849 ------------------------CGHRFCDTCLQEFL-------SEGV---FKCPEDQLP----------LDYAK--IYPDPELEQQILALPIRCIHSEEGCRWTGQMKQLQ------- B_taurus_ENSBTAP00000050075 ------------------------CGHRFCDTCLQEFL-------SEGV---FKCPEDQLP----------LDYAK--IYPDPELEVQVLGLSIRCIHSEEGCRWNGPLRHLQ------- M_musculus_ENSMUSP00000017530 ------------------------CGHRFCDTCLQEFL-------SEGV---FKCPEDQLP----------LDYAK--IYPDPELEVQVLGLAIRCIHSEEGCRWSGPLRHLQ------- G_aculeatus_ENSGACP00000014759 ------------------------CGHRFCDTCLQEFL-------SEGV---FKCPEDQLP----------LDYAK--IYPDPELEQQILALPIRCIHSEEGCRWTGQMKQLQ------- R_norvegicus_ENSRNOP00000018468 ------------------------CGHRFCDTCLQEFL-------SEGV---FKCPEDQLP----------LDYAK--IYPDPELEVQVLGLAIRCIHSEEGCRWSGPLRHLQ------- T_rubripes_ENSTRUP00000012878 ------------------------CGHRFCDTCLQEFL-------SEGV---FKCPEDQLP----------LDYAK--IYPDPELEQQILALAIRCIHSEEGCRWTGQMKQLQ------- O_latipes_ENSORLP00000005579 ------------------------CGHRFCDTCLQEFL-------SEGV---FKCPEDQLP----------LDYAK--IYPDPELEQQILSLPIRCIHSEEGCRWTGQMKQLQ------- M_domestica_ENSMODP00000024090 ------------------------CGHRFCDTCLQEFL-------SEGV---FKCPEDQLP----------LDYAK--IYPDPELEAQVLSLPIRCIHSEEGCRWTGALRQLQ------- X_tropicalis_ENSXETP00000056667 ---------------------------------------------SEGV---FKCPEDQLP----------LDYAK--IYPDRDLETQVMGLSIRCIHSEEGCRWSGQLKQLQ------- A_gambiae_AGAP010017-PA NVLPITPPPAPPRNKST--S----TSSASTMSSSSSPS-------SSSS---SPTP---PPNVP-------ITEISQIIYPDPESEKAIMGSLVFCIHHKQGCKWSDELRKLK------- A_aegypti_AAEL006649-PA NVLPITPPPAPPRNKSTTST----TSSASSSTSALSHS-------SATS---SPSP---PPNVP-------ITEISQIIYPDPESEKAIMGSLVFCIHHKQGCKWSDELRKLK------- D_rerio_ENSDARP00000056877 ------------------------CGHRFCDTCLQEYL-------SEGV---FTCPEDQLP----------LDYAK--IFPDLELEQQILSLPIRCIHSEEGCRWTAQNKLLQ------- D_melanogaster_FBpp0111838 LASPV-PPPTPPRNKTTSGSGNCATSRSSSSTVSSSHS-------SSHS---SPTPGNNNNNMP-------ITELEQIIYPGPDP-KHIMGSLVFCIHHKQGCKWSDELRKLK------- O_anatinus_ENSOANP00000019424 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000024756 ------------------------CGHRFCKACIVKSI-------RDAG---HKCPVDNAI----------LLETQ--LFPDNFAKREILSLTVKCPNEG--CLLKMELRHLE------- C_intestinalis_ENSCINP00000003738 ------------------------CEHHACSQCVSRLW-------KIS----RSCPLDGKV----------IDRNE--VTIDEKLQIELNNLNMVCPYKHCGCHWEGMFFDFK------- M_mulatta_ENSMMUP00000021907 ------------------------CGHRFCKACIIKSI-------RDAG---HKCPVDNEI----------LLENQ--LFPDNFAKREILSLMVKCPNEG--CLHKMELRHLE------- D_rerio_ENSDARP00000036715 ------------------------CGHRFCDSCIRKSI-------RDTG---QKCPVDNEV----------LLEEQ--LFPDNFAKREILSLTVKCSNFG--CSEKMELRQLE------- M_musculus_ENSMUSP00000004949 ------------------------CGHRFCKACIIKSI-------RDAG---HKCPVDNEI----------LLENQ--LFPDNFAKREILSLTVKCPNKG--CLQKMELRHLE------- H_sapiens_ENSP00000316840 ------------------------CGHRFCKACIIKSI-------RDAG---HKCPVDNEI----------LLENQ--LFPDNFAKREILSLMVKCPNEG--CLHKMELRHLE------- R_norvegicus_ENSRNOP00000006148 ------------------------CGHRFCKACITKSI-------RDAG---HKCPVDNEI----------LLENQ--LFPDNFAKREILSLTVKCPNKG--CVQKMELRHLE------- P_pygmaeus_ENSPPYP00000003845 ------------------------CGHRFCKACIIKSI-------RDAG---HKCPVDNEI----------LLENQ--LFPDNFAKREILSLMVKCPNEG--CLHKMELRHLE------- P_troglodytes_ENSPTRP00000006096 ------------------------CGHRFCKACIIKSI-------RDAG---HKCPVDNEI----------LLENQ--LFPDNFAKREILSLMVKCPNEG--CLHKMELRHLE------- O_anatinus_ENSOANP00000018657 ------------------------CGHRFCKACIVKSI-------RDAG---HKCPVDNEI----------LLENQ--LFPDNFAKREILSLMVRCPNEG--CLMKMELRQLE------- O_cuniculus_ENSOCUP00000010330 ------------------------CGHRFCKACIIKSI-------RDAG---HKCPVDNEI----------LLENQ--LFPDNFAKREILSLTVKCPNEG--CLHKMELRHLE------- G_gorilla_ENSGGOP00000005734 ------------------------CGHRFCKACIIKSI-------RDAG---HKCPVDNEI----------LLENQ--LFPDNFAKREILSLMVKCPNEG--CLHKMELRHLE------- A_carolinensis_ENSACAP00000005007 ------------------------CGHRFCKACIVKSI-------RDAG---HKCPIDNEI----------LLETQ--LFPDNFAKREILSLTVKCPNKG--CDQKMELRHLE------- T_guttata_ENSTGUP00000010462 ------------------------CGHRFCKGCIVKSI-------RDAG---HKCPVDNEI----------LLENQ--LFPDNFAKREILSLMVKCPNKG--CSMKMELRHLE------- C_familiaris_ENSCAFP00000010159 ------------------------CGHRFCKACIIKSI-------RDAG---HKCPVDNEI----------LLENQ--LFPDNFAKREILSLMVKCPNEG--CLHKMELRHLE------- X_tropicalis_ENSXETP00000016445 ------------------------CGHRFCKACILKSI-------RDAG---HKCPVDNES----------LMENQ--LFPDNFAKREILSLRVKCPSQG--CTETMELRHLE------- B_taurus_ENSBTAP00000021630 ------------------------CGHRFCKACIIKSI-------RDAG---HKCPVDNEI----------LLENQ--LFPDNFAKREILSLMVKCPNEG--CLHKMELRHLE------- E_caballus_ENSECAP00000018618 ------------------------CGHRFCKACIIKSI-------RDAG---HKCPPD-EI----------LYHP-----ASSLTRRESL-LCPMCPHCM--CYPPSKLYHRS------- G_gallus_ENSGALP00000012873 ------------------------CGHRFCKGCIVKSI----RRCRDAG---HKCPVDNEI----------LLENQ--LFPDNFAKREILSLTVKCPNKG--CCLKMELRHLE------- T_nigroviridis_ENSTNIP00000012472 ------------------------CGHRFCKNCIEKSI-------RDAG---QRCPVDNEM----------LSKEQ--LFPDNFAKREILSLIVRCSNPG--CTSKMELRHLE------- T_rubripes_ENSTRUP00000041697 ------------------------CGHRFCKICIEKSI-------RDAG---QRCPVDNEM----------LSKEQ--LFPDNFAKREILSLTVRCSNPG--CTGKMELRHLE------- O_latipes_ENSORLP00000001290 ------------------------CGHRFCKSCIEKSI-------RDTG---QRCPVDNEM----------LSEDQ--LFPDNFAKREILSLTVRCPNSD--CGEKMELRHLE------- M_mulatta_ENSMMUP00000022296 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021905 ------------------------CGHRFRKGCIIKSI-------RDAG---HKCPVDDEI----------LLENK--LFPDSFAKREILSLMVNCPNEG--CLHKMELRHLG------- G_aculeatus_ENSGACP00000022648 ------------------------CGHRFCKNCIEKSI-------RDTG---QRCPVDNER----------LLEDQ--LFPDNFAKREILSLTVRCPNSD--CADKMELRHLE------- C_elegans_F45G2.6 ------------------------CDHHYCRQCFENEN-------RTPG-----CAACQTI----------IQPEL--CQHDRAKQKQILALPVVCTFESSGCPWDGQLGTLH------- A_gambiae_AGAP000388-PA -----------------------------------------------------------------------IIPPS--VYPAQ------------------------------------- D_melanogaster_FBpp0074051 --------------------------MSLTKSSSRKDL---------------------------------TEQNQYQNQNENQNQPKSTTIVKYEKSSCLFCNEWFDAQTFT------- A_gambiae_AGAP003004-PA ------------------------CGHRFCRKCITDWL-------NEKN---SNCPLDNEP----------LDIKCD-IFPDNCTRREISQIKKPCPNSMRGCGEQLSPTDID------- A_aegypti_AAEL011363-PA ------------------------IFYSFRRNLLIQIP---------------------------------HIHNLHLRTTDKITNPILTRLLTPC-----------SFSTFQ------- D_melanogaster_FBpp0071136 ------------------------CGHRFCRSCLTAWM-------QKNN---QCCPMDNKR----------LSAEHD-IFPDNYTRREIEQLKRDCPNSSLGCSVVASPIELH------- A_aegypti_AAEL015342-PA ------------------------MLYSFRRNLLIQVP---------------------------------HIHNLHLRTTDKITNPELTRLLTPC-----------SFPTFQ------- A_carolinensis_ENSACAP00000017602 ------------------------MGMIFLKCLCLTKL---------------------------------RLPRFHKIEPWQLNTEHIWLTFIFFFSCW-------------------- 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000362994 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000036416 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000021917 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000026496 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000009372 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000041215 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000028234 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000004916 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000031262 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000002249 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000024498 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000001757 ------------------------------------------PQDH--Q-AECDCALIPCHA------GCGLMIMRKK----LPD----HLENGCAKSPTTCLKCKQTFCSMEY------ T_guttata_ENSTGUP00000006737 --------------------------------------------EH--Q-SLCEYALIPCHT------GCGHVVMRRK----LAD----HLENGCVNNVTVCQQCQCSLATSEC-Q--VR G_gallus_ENSGALP00000002401 --------------------------------------------EH--Q-ILCEYALIPCHT------GCGHVVMRKK----LAD----HLENGCVNNVTVCHKCKQSLSSSEY-Q--PH D_rerio_ENSDARP00000091948 -------------------------------------------QDH--Q-SQCEYALIPCNI------GCGIMVQRKT----LAT----HLESGCPNNKTACPSCTSVLTPREL-Q--V- T_nigroviridis_ENSTNIP00000011878 -------------------------------------------AQH--E-GRCEFEQIKCDA-------CQAFVLRAE----KDR----HNERECEARTLNCKYCKFTFHFKDI-K--AH T_rubripes_ENSTRUP00000015632 -------------------------------------------LNH--E-GKCEFMIISCPS-------CKEHIRFNE----QER----HNERECPERTLNCKYCKEPFHFKNI-K--AH D_rerio_ENSDARP00000069217 -------------------------------------------NQH--E-GRCAFERVKCEA-------CQVLILLSE----KDR----HNERECEARTLNCKYCKVTFNFKEI-K--AH T_rubripes_ENSTRUP00000047803 -------------------------------------------AQH--E-GRCELEQIKCDA-------CQASVLRAE----IDR----HNERECEARTLNCKYCKLTFHFKDI-K--AH O_latipes_ENSORLP00000020860 -------------------------------------------ASH--E-GSCDFTIIMCPS-------CKELMRANE----QER----HNERECPERTLNCKYCKEPFLLKNI-K--AH T_rubripes_ENSTRUP00000011363 -------------------------------------------ARH--E-DSCDFMIILCPS-------CKELMRVNE----QER----HNERECPERTLNCKYCKDPFQLKNI-K--AH O_latipes_ENSORLP00000003220 -------------------------------------------LDH--E-GKCEFMIIPCPS-------CKERIRFSE----QER----HSERECPERTLNCKYCKEPFHFKNI-K--AH G_gallus_ENSGALP00000014649 -------------------------------------------SCH--E-GNCPFLLIECQA-------CRGVIPLNE----KER----HSERECPERTLNCKYCKSLFYFPDI-K--AH C_familiaris_ENSCAFP00000028895 -------------------------------------------SCH--E-GHCPFMLTECPA-------CKGLVRLGE----KEH----HSEHECPERSLSCRHCRAPCCWADL-K--AH M_domestica_ENSMODP00000021625 -------------------------------------------SCH--E-GHCSFMLIECPA-------CKWMIKLGE----KEH----HSERECPKRSLNCRYCKALFYYPDI-K--AH D_rerio_ENSDARP00000043465 -------------------------------------------ANH--E-GKCDFRILPCPS-------CKELLRANE----LER----HNERECPERTLNCKYCKEPFHFKNI-K--AH O_latipes_ENSORLP00000008989 -------------------------------------------AKH--E-GRCEFEQIQCEA-------CQALVLRKD----KDR----HNDRECEERTLNCKYCKVTFNFKDI-K--AH T_nigroviridis_ENSTNIP00000016461 -------------------------------------------LSH--E-GKCEFMIISCPS-------CKEHIRFNE----QER----HNERECPERTLNCKYCKEPFHFKNI-K--AH E_caballus_ENSECAP00000011150 -------------------------------------------SCH--E-GHCPFMLTECPA-------CKGLVRLGE----KEH----HLEHECPERSLSCRHCRAPCCWADM-K--AH T_guttata_ENSTGUP00000002510 -------------------------------------------VQA--K-ARLGTSASFFPL-------C-----LGK----AQRVVCAHVGESCQIPGLYCQLEKFP-NVVHM-V--LH G_aculeatus_ENSGACP00000022084 -------------------------------------------AQH--E-GRCELERMQCEA-------CKMSVLCTD----KDR----HNERECEERTLNCKYCKMTFNFKEI-K--AH P_pygmaeus_ENSPPYP00000022191 -------------------------------------------SCH--E-GRCPLMLTECPA-------CKGLVRLGE----KER----HLEHECPERSLSCRHCRAPCCGADV-K--AH M_mulatta_ENSMMUP00000015132 TVTEPAVGSRPRSPSGRDLVLHVLTGAEACLMSVEEETELLLRSCH--E-GRCPLMLTECPA-------CKGLVRLGE----KER----HLEHECPERSLSCRHCRAPCCGADG-K--AH P_troglodytes_ENSPTRP00000036949 -------------------------------------------SCH--E-GRCPLMLTECPA-------CKGLVRLGE----KER----HLEHECPERSLSCRHCRAPCCGADV-K--AH M_musculus_ENSMUSP00000109872 -------------------------------------------SCH--E-GLCPFLLTECPA-------CKGLVRLSE----KEH----HTEQECPKRSLSCQHCRAPCSHVDL-E--VH H_sapiens_ENSP00000247668 -------------------------------------------SCH--E-GRCPLMLTECPA-------CKGLVRLGE----KER----HLEHECPERSLSCRHCRAPCCGADV-K--AH G_aculeatus_ENSGACP00000006974 -------------------------------------------ASH--E-DNCDFMIIMCPS-------CKELMRANE----QER----HNERECPERTLNCRYCKEPFLLKNI-K--AH T_nigroviridis_ENSTNIP00000013509 -------------------------------------------ARH--E-DSCDFMIILCPS-------CKELMRANE----QER----HNERECPERTLNCKYCKEAFQLKSI-K--AH B_taurus_ENSBTAP00000013869 -------------------------------------------SCH--E-GQCPFMLTECPA-------CKGLVRLGE----KEH----HLEHQCPERSLSCRHCRAPCSPADM-K--AH X_tropicalis_ENSXETP00000042386 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000008559 -------------------------------------------YCY--S-LGTCTALTHCVL-------CPGYPWNYS----GDL----HSERECPERKLNCRYCKLSFYFPDI-K--AH G_aculeatus_ENSGACP00000020860 -------------------------------------------LTH--E-GKCEFMIIPCPS-------CKERIRFNE----QER----HNERECPERTLNCKYCKEPFHFKNI-K--AH G_gorilla_ENSGGOP00000004192 --------------------------------------------XX--XXXXXXXXXXXXXXX-----XXXXXXXXXX----XXX----XXXXXXXXXXXXXXXXXXXXXXXXX-X--KH H_sapiens_ENSP00000376500 --------------------------------------------VH--LKNDCHFEELPCVRP-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMIAL-Q--KH P_troglodytes_ENSPTRP00000011503 --------------------------------------------VH--LKNDCHFEELPCVRP-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMIAL-Q--KH P_pygmaeus_ENSPPYP00000007003 --------------------------------------------VH--LKNDCHFEELPCVRP-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMIAL-Q--KH G_gallus_ENSGALP00000036699 --------------------------------------------MH--LKTDCQFEELPCPRA-----DCKEKILRKD----LPD----HVEKTCKYRETTCKYCKSQVPMIML-Q--KH R_norvegicus_ENSRNOP00000010906 --------------------------------------------VH--LKNECQFEELPCLRA-----DCKEKVLRRD----LRD----HVEKACKYREATCAHCKSQVPMITL-Q--KH T_guttata_ENSTGUP00000013203 --------------------------------------------MH--LRTDCQFEELPCPRA-----DCKEKILRKD----LPD----HVEKTCKYRETTCKYCKSQVPMIML-Q--KH O_anatinus_ENSOANP00000023053 --------------------------------------------VH--LKSDCQFEELSCPRA-----DCKEKVLRKD----LPD----HIEKSCKYREATCKYCTSQVPMITL-Q--KH B_taurus_ENSBTAP00000017918 --------------------------------------------VH--LKNDCQFEELPCVRA-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMVTL-Q--KH C_familiaris_ENSCAFP00000026713 --------------------------------------------VH--LKNDCQFEELSCVRA-----DCKEKVLRRD----LRD----HVEKACKYREATCPHCKSQVPMITL-Q--KH E_caballus_ENSECAP00000011833 --------------------------------------------VH--LKNDCQFEELACVRP-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMITL-Q--KH M_musculus_ENSMUSP00000021706 --------------------------------------------VH--LKNECQFEELPCLRA-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMIKL-Q--KH X_tropicalis_ENSXETP00000027864 --------------------------------------------IH--LKSDCQFEELSCPRA-----DCKEKVIRKD----LSD----HIEKTCKYRETPCKFCRNQVPLVEM-Q--KH M_domestica_ENSMODP00000016701 --------------------------------------------VH--LKSECQFEELPCVRA-----DCKEKILRKD----LQD----HVEKSCKYREATCQYCKSQVPMITL-Q--KH A_carolinensis_ENSACAP00000000193 --------------------------------------------TH--LRNDCLFEELPCPRV-----DCKEKILRKD----LPD----HAEKTCKYRETTCKYCKSQVPIIMI-Q--KH T_rubripes_ENSTRUP00000013348 --------------------------------------------DH--L-NTCPFFEVPCPLG-----KCKERMMRKE----IPE----HLSWKCKYRETSCEFCMTKMPLTEL-Q--KH D_rerio_ENSDARP00000038596 --------------------------------------------EH--L-VICPYFEVPCPLG-----KCKEKMMRKD----MPE----HLSRKCKHREVTCEFCSLKMALTEL-Q--KH T_nigroviridis_ENSTNIP00000005138 --------------------------------------------DH--L-NVCPFFEVPCPLG-----KCKERMMRKE----IPD----HLSWKCKFRESSCEFCMTKMPLTEL-Q--KH G_aculeatus_ENSGACP00000005703 --------------------------------------------DH--L-NVCPFFEVPCPLG-----KCKERMMRKE----IPD----HLSWKCKHRETSCEFCMTKMPLTDL-Q--KH C_intestinalis_ENSCINP00000003143 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000015940 --------------------------------------------DH--L-QHCLFQPVQCSNE-----NCREPVLRKD----LKE----HLSAYCQFREEKCLYCKKDVVVINL-Q--NH C_intestinalis_ENSCINP00000001432 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000015419 --------------------------------------------VH--LKNDCHFEELPCVRA-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMIAL-Q--KH M_mulatta_ENSMMUP00000038268 --------------------------------------------DH--L-QQCLFQAVQCSNE-----NCQEPVLRKD----LKE----HLSAYCQFREEKCLYCKKDVVVINL-Q--NH P_pygmaeus_ENSPPYP00000000253 --------------------------------------------DH--L-QQCLFQAVQCSNE-----KCREPVLRKD----LKE----HLSAYCQFREEKCLYCKKDVVVINL-Q--NH P_troglodytes_ENSPTRP00000003288 --------------------------------------------DH--L-QQCLFQAVQCSNE-----KCREPVLRKD----LKE----HLSAYCQFREEKCLYCKKDVVVINL-Q--NH E_caballus_ENSECAP00000005414 --------------------------------------------DH--L-QQCLFQAVQCSNE-----HCQESVLRKN----LKE----HLSAYCQFREEKCLYCKKDVVVINL-Q--NH C_intestinalis_ENSCINP00000027890 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000017853 --------------------------------------------QYIWL-QYSTPRAKVRVNRRSIGTSCKHTMCRGS----EGE----LLSHETALPGSSILLGKQEACILSLSQ--NH C_intestinalis_ENSCINP00000001022 -------------------------------------------------------------------------------------------------------------------S--RH H_sapiens_ENSP00000336825 --------------------------------------------DH--L-QQCLFQPVQCSNE-----KCREPVLRKD----LKE----HLSASCQFRKEKCLYCKKDVVVINL-Q--NH O_cuniculus_ENSOCUP00000003184 --------------------------------------------VH--LKNDCQFEELACVRA-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMITL-Q--XX R_norvegicus_ENSRNOP00000058607 -------------------------------------------SCH--E-GLCPFLLTECPA-------CKGLVRLSE----KKH----HTEQECPKRSLSCQHCRAPCSHADL-E--LH M_musculus_ENSMUSP00000082710 --------------------------------------------DH--L-QHCSFQAVPCPNE-----SCREAMLRKD----VKE----HLSAYCRFREEKCLYCKRDIVVTNL-Q--DH T_guttata_ENSTGUP00000003276 --------------------------------------------EH--L-QQCLFECTQCTND-----GCRDRVLRKD----LKE----HLRQQCKFREERCQYCNTYVVFINI-E--NH G_gallus_ENSGALP00000016021 --------------------------------------------EH--L-QQCLFESVQCTND-----GCCDQILRKD----LKD----HLSQHCKFREEMCQYCNKYVVLINI-K--NH C_intestinalis_ENSCINP00000005981 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000025605 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000017068 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000013484 --------------------------------------------DH--L-QQCLFQPVQCSNE-----SCQEKVLRKD----MKD----HLGCHCKFREEKCQYCQKYVVAIDL-Q--NH A_carolinensis_ENSACAP00000016112 --------------------------------------------DH--L-QQCLFESVQCTNE-----GCCEKVLQKD----LKE----HLGLHCNYRKELCRYCNQPVTSINV-K--TH M_domestica_ENSMODP00000003305 --------------------------------------------DH--L-LQCLFQSVQCSNE-----CCQERILRKD----LKN----HLELHCQFREEMCPFCNKDVVIIDL-Q--NH O_cuniculus_ENSOCUP00000007884 --------------------------------------------EH--L-QQCLFQVVQCSHD-----SCQEPVLRRD----LNE----HLSAYCQFREEKCLYCKKDVVVMDL-Q--NH A_carolinensis_ENSACAP00000010321 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000031605 --------------------------------------------EH--L-GQCLYEMTLCSND-----GCHDQMIRKE----LKG----HLESECKLRQEACIYCKQTMASINL-T--IH G_gorilla_ENSGGOP00000006994 -------------------------------------------SCH--E-GRCPLMLTECPA-------CKGLVRLGE----KER----HLEHECPERSLSCRHCRAPCCGADV-K--AH O_latipes_ENSORLP00000001368 --------------------------------------------EH--L-KSCQYEQLLCSNP-----GCTELLQRRL----LQE----HLNATCPHRRESCPHCLQPFQLSVI-Q--DH G_aculeatus_ENSGACP00000025883 --------------------------------------------VE--P-THKQSDNLVSPE------DVQRFLLKNQQLCPLQE----HLADTCPLRGEPRPHRQPPQRLTFI-Q--DR D_rerio_ENSDARP00000014326 --------------------------------------------DH--L-KACPHERVRCSHS-----DCSDIVLRKN----LLE----HQRNACSYRLETCHYCRQNFPVSQMMQ--GH C_intestinalis_ENSCINP00000027041 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000015252 --------------------------------------------GH--L-NTCSFNVIPCPN------RCPMKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SH P_pygmaeus_ENSPPYP00000009119 --------------------------------------------GH--L-NTCSFNVIPCPN------RCPMKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SH M_mulatta_ENSMMUP00000028200 --------------------------------------------GH--L-NTCSFNVVPCPN------RCPMKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SH B_taurus_ENSBTAP00000016271 --------------------------------------------GH--L-NTCSFNVVPCPN------RCPAKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAF-E--SH H_sapiens_ENSP00000262395 --------------------------------------------GH--L-NTCSFNVIPCPN------RCPMKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SH T_nigroviridis_ENSTNIP00000019321 -----------------------------------------------------------------------VKLTRRD----LPD----HLQHDCPKRKVKCEFCGSEFTGEAY-E--NH G_gorilla_ENSGGOP00000016344 --------------------------------------------XX--X-XXXXXXXXXXXX------RCPMKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SH E_caballus_ENSECAP00000009502 --------------------------------------------GH--L-NTCSFNVVPCPN------RCPTKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAF-E--SH D_rerio_ENSDARP00000013849 --------------------------------------------SH--F-STCAFNVIPCPN------RCSVKLTRRD----LPE----HLQHDCPKRKVKCEFCGSEFTGEAY-E--NH B_taurus_ENSBTAP00000050075 --------------------------------------------GH--L-NTCSFNVVPCPN------RCPAKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAF-E--SH M_musculus_ENSMUSP00000017530 --------------------------------------------GH--L-NTCSFNVVPCPN------RCPAKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SH G_aculeatus_ENSGACP00000014759 --------------------------------------------GH--F-STCAFNVIPCPN------RCSVKLTRRD----LPD----HLQHDCPKRKVKCEFCGSEFTGEAY-E--NH R_norvegicus_ENSRNOP00000018468 --------------------------------------------GH--L-NTCSFNVVPCPN------RCPAKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SH T_rubripes_ENSTRUP00000012878 --------------------------------------------GH--F-STCAFNVIPCPN------RCSVKLTRRD----LPD----HLQHDCPKRKVKCEFCGSEFTGEAY-E--NH O_latipes_ENSORLP00000005579 --------------------------------------------GH--F-STCAFNVIPCPN------RCSVKLTRRD----LPD----HLQHDCPKRKVKCEFCGSEFTGEAF-E--NH M_domestica_ENSMODP00000024090 --------------------------------------------VH--L-SSCGYNVVACPN------RCNGKLSRRD----LPS----HLQHECPKRRLKCDFCGIDFTGEAF-E--SH X_tropicalis_ENSXETP00000056667 --------------------------------------------PH--L-NICAFNVIPCPN------RCSTKLIRRD----LPE----HMQHDCPKRKVRCEFCGADFTGEAY-E--DH A_gambiae_AGAP010017-PA --------------------------------------------AH--L-NTCKHDAIQCPN------KCGSQIPRVM----MTD----HLAFTCILRRAICEFCNVEFTGIGL-E--EH A_aegypti_AAEL006649-PA --------------------------------------------AH--L-NTCKHDAIQCPN------KCGSQIPRVM----MTD----HLAFTCILRRAICEFCNVEFTGIGL-E--EH D_rerio_ENSDARP00000056877 --------------------------------------------AH--L-SVCEFNVVSCPN------RCSVKLLRRE----LPE----HLQHDCAKRKLHCDHCGEQFTGEAY-E--NH D_melanogaster_FBpp0111838 --------------------------------------------GH--L-NACKHDATQCPN------KCGAQIPRIM----MTD----HLQYTCTMRRTRCEFCQSEFSGAGL-E--EH O_anatinus_ENSOANP00000019424 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000024756 --------------------------------------------DH--Q-THCEFALAECPQ-------CHLPFRKYL----LHN----HMVVECPRRQVSCVNCAAPMPFEEK-EAKFH C_intestinalis_ENSCINP00000003738 --------------------------------------------SH--Y-DECLYTEEVCSN------DCGFRCSKHL----MDN----HLQIECSKRLVVCEFCALHLKAENEIE---H M_mulatta_ENSMMUP00000021907 --------------------------------------------DH--Q-AHCEFALVDCPQ-------CQRPFQKFH----INI----HILKDCPRRQVSCDNCAALVAFEDK-E--IH D_rerio_ENSDARP00000036715 --------------------------------------------KH--L-SQCRFATAPCPQ-------CQESVPISH----LDE----HKSQHCLQRIMTCPDCAGSFVYAVK-Q--NH M_musculus_ENSMUSP00000004949 --------------------------------------------DH--Q-VHCEFALVNCPQ-------CQRPFQKCQ----VNT----HIIEDCPRRQVSCVNCAVSMAYEEK-E--IH H_sapiens_ENSP00000316840 --------------------------------------------DH--Q-AHCEFALMDCPQ-------CQRPFQKFH----INI----HILKDCPRRQVSCDNCAASMAFEDK-E--IH R_norvegicus_ENSRNOP00000006148 --------------------------------------------DH--Q-VHCEFALVICPQ-------CQRFFQKCQ----INK----HIIEDCPRRQVSCVNCAVPMPYEEK-E--IH P_pygmaeus_ENSPPYP00000003845 --------------------------------------------DH--Q-AHCEFALMDCPQ-------CQRPFQKFH----INI----HILKDCPRRQVSCDNCAASMAFEDK-E--IH P_troglodytes_ENSPTRP00000006096 --------------------------------------------DH--Q-AHCEFALMDCPQ-------CQRPFQKFH----INI----HILKDCPRRQVSCDNCAASMAFEDK-E--IH O_anatinus_ENSOANP00000018657 --------------------------------------------EH--Q-SLCDYALVECPQ-------CHISFQKNI----LHD----HVVSECPRRQVSCVNCALSMAFEDK-E--YH O_cuniculus_ENSOCUP00000010330 ------------------------------------------XXXX--X-XXXXXXXXXXXX-------XXXXXXXXX----XXX----XXXXXXXXXXXXXXXXXXXXXXXXX-X--IH G_gorilla_ENSGGOP00000005734 --------------------------------------------XX--X-XXXXXXXXXXXX-------XXXXXXXXX----XXX----XXXXXXXXXXXXXXXXXXXXXXXXX-X--XX A_carolinensis_ENSACAP00000005007 --------------------------------------------DH--Q-QHCGFASEKCPQ-------CQGIFQKNR----LQE----HIKLECPRRQVSCPNCALLMPYEDK-E--VH T_guttata_ENSTGUP00000010462 --------------------------------------------DH--Q-LQCDFSTVECLQ-------CQGTFPKNH----LKE----HMTQECPRRQVCCPNCATSMAYEDK-E--LH C_familiaris_ENSCAFP00000010159 --------------------------------------------DH--Q-LHCEFALMNCLQ-------CQRTFQKCQ----LNI----HILKECPRRQVSCMNCAALMAFEDK-E--IH X_tropicalis_ENSXETP00000016445 --------------------------------------------RH--L-VRCDFAGVECSQ-------CQSSFPKYS----LQK----HMFEECPRRQIFCENCALAMALEDK-L--NH B_taurus_ENSBTAP00000021630 --------------------------------------------EH--Q-AHCEFALMSCPQ-------CQRPFQKCH----LNI----HILKECPRRQVPCENCAVSMAFEDK-E--IH E_caballus_ENSECAP00000018618 --------------------------------------------DH--Q-AHCEFALMNCPQ-------CQHPFQKCQ----LNI----HMLKECPRRQVSCVNCAVSMAFEDK-EASIH G_gallus_ENSGALP00000012873 --------------------------------------------EH--Q-LHCDFTTVECPQ-------CQGAFQKNH----LKE----HMTQECPRRQVCCPNCATSMAYEDK-E--LH T_nigroviridis_ENSTNIP00000012472 --------------------------------------------NH--L-ASCEFATVPCPH-------CQQSVKKTL----LEE----HTSVQCRRRPVSCPDCVEIFVYEEK-E--RH T_rubripes_ENSTRUP00000041697 --------------------------------------------DH--L-AHCQFATVPCPH-------CQQSVRKTI----LEE----HMTAECRRRPVSCPDCIETFVYEER-E--RH O_latipes_ENSORLP00000001290 --------------------------------------------KH--L-AQCQFATVPCSQ-------CQQPVRKSY----LEE----HATVECPRRPMSCPDCVAVFVYEER-E--MH M_mulatta_ENSMMUP00000022296 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021905 --------------------------------------------DH--Q-AHCEFALMDCPQ-------CQHPFQKFH----INI----HILKDCPRRQVSCDNCAASMAFIKR-S--V- G_aculeatus_ENSGACP00000022648 --------------------------------------------NH--L-GRCQFATVPCSQ-------CQQAVRKSR----LEE----HQTAECQKRPVSCPDCVASFFYEER-K--LH C_elegans_F45G2.6 --------------------------------------------DH--L-SECTFKSSLKCE------KCGRQFAKND----LEK----HRA-KCELNRAVCSFCNKTIRDSDR-E--RH A_gambiae_AGAP000388-PA --------------------------------------------IH--L-RKCRRQQTVCPN------RCGAIVAKKD----LQL----HSN-TCPKSYG-MESSNEPSNEYDKMQHSLD D_melanogaster_FBpp0074051 --------------------------------------------EH--L-IHCGQVLEECPN------GCQAFIPRIR----MRS----HLK-ECPRNQHNLSNQQRMSVSMDRLDRQSD A_gambiae_AGAP003004-PA --------------------------------------------TH--L-RQCPFAMSRQSQ---------------------------------------------------------- A_aegypti_AAEL011363-PA --------------------------------------------SH--I-ADCGQVLSKCPN------GCGVYVALKD----MDR----HLN-RCPAGFGEAPHQDGD------------ D_melanogaster_FBpp0071136 --------------------------------------------RH--L-PSCPYRRQQEPQ---------------------------------------------------------- A_aegypti_AAEL015342-PA --------------------------------------------SH--I-ADCGQVLSKCPN------GCGVYVALKD----MDR----HLN-RCPAGFGEAPHQDGD------------ A_carolinensis_ENSACAP00000017602 --------------------------------------------SYVGN-RHTGRQELSIGN------NCDRIATIEHEF--LHALGFWHEQSRSDRDDYVTIMRDRIQAGKESNFNKYD 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000362994 ----------------------------------------------------------------------------------KAHPE--VAEA--GIGCPFAGVGCS---F-K-GSPQSV P_troglodytes_ENSPTRP00000036416 ----------------------------------------------------------------------------------KAHPE--VAEA--GVGCPFAGVGCS---F-K-GSPQSV P_pygmaeus_ENSPPYP00000021917 ----------------------------------------------------------------------------------KAHPE--VAEA--GVGCPFAGVGCS---F-K-GSPQSV M_mulatta_ENSMMUP00000026496 ----------------------------------------------------------------------------------RAHPE--VAEA--GVGCPFAGVGCS---F-K-GSPQSV E_caballus_ENSECAP00000009372 ----------------------------------------------------------------------------------KVHSD-AVAEA--GVGCPFAGVGCS---F-K-GSPKFM B_taurus_ENSBTAP00000041215 ----------------------------------------------------------------------------------KDHPE--VAEA--GVGCPFAGVGCS---F-K-GSPKFM M_musculus_ENSMUSP00000028234 ----------------------------------------------------------------------------------KVHSD--VAEA--EIMCPFAGVGCS---F-K-GSPQSM O_cuniculus_ENSOCUP00000004916 ----------------------------------------------------------------------------------KXXXX--XXXX--XXXXXXXXXXXX---X-X-GNAQSL C_familiaris_ENSCAFP00000031262 ----------------------------------------------------------------------------------KDPPE--VAEA--EVGCPFAGVGCP---Y-K-GSPRLM G_gorilla_ENSGGOP00000002249 ----------------------------------------------------------------------------------KAHPE--VAEA--GVGCPFAGVGCS---F-K-XXXXXX M_domestica_ENSMODP00000024498 ----------------------------------------------------------------------------------------VPAED--QDRCPFADIGCS---F-K-GGQERV O_anatinus_ENSOANP00000001757 --------------------------------------------------------------------------------QFNSPGS-TASRI--QDGCPFSVIGCS---FMH-GSREKV T_guttata_ENSTGUP00000006737 ---------------------------------------------------------TFLSQ--IKA--FQLVLIISSTFFFSSH-S-TSSSN--KDGCCFSEVGCA---F-R-GSKEKI G_gallus_ENSGALP00000002401 ---------------------------------------------------------CPRKPKVCRS--EPAVILMTGTFMLSDHLR-ASSVS--MDGCRFSEVGCS---F-G-GSKEKI D_rerio_ENSDARP00000091948 --------------------------------------------------------LLKKEKHVCPS--SGDKKTAKTDKKQKNNQP-ANSKK--KEPCIFSDVGCP---F-K-GNPDKV T_nigroviridis_ENSTNIP00000011878 D------------------------------------------------------EICSKFPLQCKD--CGK--KKIPREKFNEHIK-SCAKS--KSACPFSEVGCK---S-V-VENGKL T_rubripes_ENSTRUP00000015632 D------------------------------------------------------EICPKYPMICEG--CAK--KKIPREKYVDHIK-FCSKF--RTPCRFHVVGCD---M-S-VEKEKI D_rerio_ENSDARP00000069217 D------------------------------------------------------EICQKFPMQCKD--CGK--KKIPREKFQEHTK-SCAKS--KSACQFREIGCR---A-V-VDNCKQ T_rubripes_ENSTRUP00000047803 D------------------------------------------------------DICLKFPLPCKD--CGK--KKIPREKFNEHIR-SCAKS--KSACPFSEVGCK---S-V-VDNGKL O_latipes_ENSORLP00000020860 D------------------------------------------------------EICPKYPMMCEG--CAK--KKIPREKYVDHIK-FCSKF--KAPCRFHVVGCD---T-S-VEKEKI T_rubripes_ENSTRUP00000011363 D------------------------------------------------------EICPKYPMICEG--CSK--KKIPREKYVDHIK-YCSKF--KSPCRFHVVGCN---T-S-VEKEKI O_latipes_ENSORLP00000003220 D------------------------------------------------------EICPKYPMICEG--CAK--KKIPREKYVDHIK-FCSKF--RTPCRFHVVGCD---M-S-VEKEKI G_gallus_ENSGALP00000014649 D------------------------------------------------------EVCPKFPLTCDG--CGK--KKIPREKFQDHVK-NCGKC--KVPCRFKVVGCA---E-M-VENEKL C_familiaris_ENSCAFP00000028895 H------------------------------------------------------EVCPKFPLTCDG--CGK--KKISREKFQDHVR-ACGKC--RVPCRFHVVGCP---E-M-VESEKQ M_domestica_ENSMODP00000021625 D------------------------------------------------------EICPKFPLTCEG--CGK--KKILREKFQDHVK-ACGKC--KGPCKFHVVGCT---E-M-VENEKQ D_rerio_ENSDARP00000043465 D------------------------------------------------------EICPKYPMICEG--CAK--KKIPREKYVDHIK-LCTKF--RTPCRFHVVGCD---M-T-VEKEKI O_latipes_ENSORLP00000008989 D------------------------------------------------------EICQKFPLQCKD--CGK--KKIPREKFNDHAK-SCAKS--KSACPFSEVGCK---S-V-VENGKI T_nigroviridis_ENSTNIP00000016461 D------------------------------------------------------EICPKYPMICEG--CAK--KKIPREKYVDHIK-FCSKF--RTPCRFHVVGCD---M-S-VEKEKI E_caballus_ENSECAP00000011150 H------------------------------------------------------DVCPKFPLTCDG--CGK--KKISREKFQDHVR-TCGKC--RVPCRFHAVGCP---E-M-VESEKQ T_guttata_ENSTGUP00000002510 C------------------------------------------------------EETPHCECSWRN--CEGIWKKHPGAAFRDHVK-TCGRS--KVPCRFEAVGCA---E-V-VENEKL G_aculeatus_ENSGACP00000022084 D------------------------------------------------------EICLKFPLQCKD--CGK--KKIPREKFNDHSK-SCAKS--KSSCPFNDVGCK---Y-M-MENGKL P_pygmaeus_ENSPPYP00000022191 H------------------------------------------------------EVCPKFPLTCDG--CGK--KKIPREKFQDHVK-TCGKC--RVPCRFHAIGCL---E-T-VEGEKQ M_mulatta_ENSMMUP00000015132 H------------------------------------------------------EVCPKFPLTCDG--CGK--KKIPREKFQDHVK-TCGKC--RIPCRFHAIGCL---E-T-VEGEKQ P_troglodytes_ENSPTRP00000036949 H------------------------------------------------------EVCPKFPLTCDG--CGK--KKIPREKFQDHVK-TCGKC--RVPCRFHAIGCL---E-T-VEGEKQ M_musculus_ENSMUSP00000109872 Y------------------------------------------------------EVCPKFPLTCDG--CGK--KKIPRETFQDHVR-ACSKC--RVLCRFHTVGCS---E-M-VETENL H_sapiens_ENSP00000247668 H------------------------------------------------------EVCPKFPLTCDG--CGK--KKIPREKFQDHVK-TCGKC--RVPCRFHAIGCL---E-T-VEGEKQ G_aculeatus_ENSGACP00000006974 D------------------------------------------------------EICPKYPMICEG--CAK--KKIPREKYVDHIK-FCSKC--KAPCRFHVVGCDASVM-E-VENEKL T_nigroviridis_ENSTNIP00000013509 D------------------------------------------------------EICPKYPMMCEG--CSR--RKIPREKYVDHIK-YCSKF--KSPCRFHVVGCN---I-K-VEKEKI B_taurus_ENSBTAP00000013869 H------------------------------------------------------QICPKFPLTCDG--CGK--KKIAREKFQDHVR-ACGRC--RVPCRFHAVGCP---E-M-VESEQQ X_tropicalis_ENSXETP00000042386 --------------------------------------------------------------------------ERFAFNYTNAQLI-VCPEH-------------S---F-S-GSREKI X_tropicalis_ENSXETP00000008559 D------------------------------------------------------EICPKFPMTCEG--CGR--KKIPREKFPDHVK-ICGRC--KVPCRYAAVGCT---E-M-VENDKC G_aculeatus_ENSGACP00000020860 D------------------------------------------------------EICPKYPMICEG--CAK--KKIPREKYVDHIK-FCSKF--RTPCRFHVVGCD---M-S-VEKEKI G_gorilla_ENSGGOP00000004192 E-----------------------------------------------------DTDCPCVVVSCPH--KCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F-Q-GTNQQI H_sapiens_ENSP00000376500 E-----------------------------------------------------DTDCPCVVVSCPH--KCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F-Q-GTNQQI P_troglodytes_ENSPTRP00000011503 E-----------------------------------------------------DTDCPCVVVSCPH--KCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F-Q-GTNQQI P_pygmaeus_ENSPPYP00000007003 E-----------------------------------------------------DTDCPCVVVSCPH--KCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F-Q-GTNQQI G_gallus_ENSGALP00000036699 E-----------------------------------------------------DTDCPCVMVSCPH--KCSV-KTLMRSELNAHLS-ECINA--PSTCSFKRYGCT---F-Q-GTNQQI R_norvegicus_ENSRNOP00000010906 E-----------------------------------------------------DTDCPCVVVSCPH--KCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F-Q-GTNQQI T_guttata_ENSTGUP00000013203 E-----------------------------------------------------DTECPCVMVSCPH--KCSV-KTLMRSELNAHLS-ECINA--PSTCSFKRYGCT---F-Q-GTNQQI O_anatinus_ENSOANP00000023053 E-----------------------------------------------------DTECPCVVVSCPH--KCSV-QTLLRSELNAHLS-ECINA--PSTCSFKRYGCT---F-Q-GTNQQI B_taurus_ENSBTAP00000017918 E-----------------------------------------------------DTECPCVAVSCPH--KCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F-Q-GTNQQI C_familiaris_ENSCAFP00000026713 E-----------------------------------------------------DTECPCVVVSCPH--KCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F-Q-GTNQQI E_caballus_ENSECAP00000011833 E-----------------------------------------------------DTECPCVVVSCPH--KCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCI---F-Q-GTNQQI M_musculus_ENSMUSP00000021706 E-----------------------------------------------------DTDCPCVVVSCPH--KCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F-Q-GTNQQI X_tropicalis_ENSXETP00000027864 E-----------------------------------------------------DVDCPSVVISCPH--MCSV-KSLLRSELNAHLL-ECVNA--PSTCSFKRYGCT---F-K-GTNQQI M_domestica_ENSMODP00000016701 E-----------------------------------------------------DTECPCVVVSCPH--KCSV-QTLLRSELNAHLS-ECINA--PSTCSFKRYGCT---F-Q-GTNQQI A_carolinensis_ENSACAP00000000193 E-----------------------------------------------------DADCPCVMVTCPH--KCSV-SALLRKELNAHLS-ECINA--PSTCSFKRYGCT---F-Q-GTNQQV T_rubripes_ENSTRUP00000013348 K-----------------------------------------------------ETVCPAFPVSCPN--HCSL-SSLPRSELSSHQH-ECPKA--QVSCPFHGYGCT---F-K-GLNQVM D_rerio_ENSDARP00000038596 K-----------------------------------------------------ETVCPAFPVACPN--HCSF-SSILRSELSSHQH-DCPKA--QVTCSFIRYGCS---Y-K-GLNQEM T_nigroviridis_ENSTNIP00000005138 K-----------------------------------------------------ETVCPAFPVSCPN--HCSF-SSLPRSELSNHQH-ECPKA--QVSCQFHGYGCT---F-K-GLNQLM G_aculeatus_ENSGACP00000005703 K-----------------------------------------------------ETVCPAFPVSCPN--HCSV-SSLPRSELSSHQN-DCPKA--QVCCQFQRYGCT---F-Q-GLNQDM C_intestinalis_ENSCINP00000003143 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000015940 E-----------------------------------------------------ENLCPDYPVSCPN--KCL--QTIPRTEVDEHLA-VCPEA--EQDCAFKNYGCA---V-K-DKRGNL C_intestinalis_ENSCINP00000001432 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000015419 E-----------------------------------------------------DTDCPCVVVSCPH--KCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F-Q-GTNQQI M_mulatta_ENSMMUP00000038268 E-----------------------------------------------------ENLCPEYPVFCPN--NCA--KIILKTEVDEHLA-VCPEA--EQDCPFKHYGCA---V-T-DKRRNL P_pygmaeus_ENSPPYP00000000253 E-----------------------------------------------------ENLCPEYPVFCPN--NCA--KIILKTEVDEHLA-VCPEA--EQDCPFKHYGCA---V-T-DKRRNL P_troglodytes_ENSPTRP00000003288 E-----------------------------------------------------ENLCPEYPVFCPN--NCA--KIILKTEVDEHLA-VCPEA--EQDCPFKHYGCA---V-T-DKRRNL E_caballus_ENSECAP00000005414 E-----------------------------------------------------ENMCPEYPVSCPN--KCL--QIIPRTEVDEHLA-VCPEA--EQDCPFKQYGCP---V-K-DKRGNL C_intestinalis_ENSCINP00000027890 L-----------------------------------------------------STENVS-PSLQRS--S-------V---FNSWTS-KSPID--FSISEPSFNFNG---L-S-HPEVGI C_familiaris_ENSCAFP00000017853 E-----------------------------------------------------ENLCPEYPVPCPN--KCS--QIIPRTEVDEHLT-VCPEA--EQDCPFKHYGCT---V-K-DKRGSL C_intestinalis_ENSCINP00000001022 Q-----------------------------------------------------SGENSSFASSQPE--S-------VDQIPQNHLN-ESPYV--LNNEALSLESSL---T-T-GDLNSV H_sapiens_ENSP00000336825 E-----------------------------------------------------ENLCPEYPVFCPN--NCA--KIILKTEVDEHLA-VCPEA--EQDCPFKHYGCA---V-T-DKRRNL O_cuniculus_ENSOCUP00000003184 X-----------------------------------------------------XXXXXXXXXXXXX--XXXX-XXXXXXXLSAHLS-ECVNA--PSTCSFKRYGCV---F-Q-GTNQQI R_norvegicus_ENSRNOP00000058607 Y------------------------------------------------------EVCPKFPLTCDG--CG---KKISQEKLQDHVR-TCSKC--RVLCRFHAIGCS---E-L-VETEDL M_musculus_ENSMUSP00000082710 E-----------------------------------------------------ENSCPAYPVSCPN--RCV--QTIPRARVNEHLT-VCPEA--EQDCPFKHYGCT---V-K-GKRGNL T_guttata_ENSTGUP00000003276 E-----------------------------------------------------KNDCPDYPVPCLQ--NCS--QIILKKEIEKHHA-VCPEA--EVDCPYKQYGCH---V-K-VKRGKL G_gallus_ENSGALP00000016021 E-----------------------------------------------------ENDCPDYPMPCLQ--NCS--QIILKKEIEKHHT-VCPET--EVDCPYKQYGCL---I-K-VKRGKL C_intestinalis_ENSCINP00000005981 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000025605 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000017068 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000013484 E-----------------------------------------------------ENFCPDYPVSCPF--SCC--QIIPRTEVDEHIS-VCPEA--EQDCPYKQYGCL---I-K-DKRRNL A_carolinensis_ENSACAP00000016112 E-----------------------------------------------------RRDCPEYPLICPH--GCT--QTILMKEAEEHIL-VCPAV--EIDCPYKQYGCP---A-K-IKRGKV M_domestica_ENSMODP00000003305 K-----------------------------------------------------EQFCPNYPVSCPN--NCL--QIITRTKVNEHIS-VCPEV--EQECAYKHYGCP---V-K-DKRSNL O_cuniculus_ENSOCUP00000007884 E-----------------------------------------------------ENLCPEYPVSCPN--KCL--QIIPRTEVNRHLA-VCPEA--EQDCPFKQYGCT---V-K-EKRGSL A_carolinensis_ENSACAP00000010321 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000031605 V-----------------------------------------------------GLYCQLYPVPCPN--ACP--VTCPRAELDKHLC-ECPEA--ELQCTFSNYGCN---V-M-VKRGKV G_gorilla_ENSGGOP00000006994 H------------------------------------------------------EVCPKFPLTCDG--CGK--KKIPREKFQDXVK-TCGKC--RVPCRFHAVGCL---E-T-VEGEKQ O_latipes_ENSORLP00000001368 V-----------------------------------------------------QSSCPKVKGGCPD--GCS--TLVPKNRLTEHGE-SCPEV--HTDCSFKMFGCS---V-K-GKRRKV G_aculeatus_ENSGACP00000025883 V-----------------------------------------------------QSSC--LQVDCPE--SCS--PKAPRHKLE-----SCPEQVEQVDCSYKKFGCS---V-Q-DTRGRV D_rerio_ENSDARP00000014326 Q-----------------------------------------------------KSSCPDVEVPCSN--NCT--QMIKRHQLQAHAD-ECLEV--ETDCVYKNYGCT---V-R-DKRGKV C_intestinalis_ENSCINP00000027041 --------------------------------------------------------------------------------------------------------GSE---V-E-DEGEDT P_troglodytes_ENSPTRP00000015252 EGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPN--QCGV-GTVAREDLPGHLKDSCNTA--LVLCPFKDSGCK---H-R-CPKLAM P_pygmaeus_ENSPPYP00000009119 EGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCSKEFVFDTIQSHQYQCPRLPVACPN--QCGV-GTVAREDLPGHLKDSCNTA--LVLCPFKDSGCK---H-R-CPKLAM M_mulatta_ENSMMUP00000028200 EGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVPCPN--QCGV-GTVAREDLPGHLKDSCSTA--LVLCPFKDSGCK---H-R-CPKLAM B_taurus_ENSBTAP00000016271 EGVCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVPCPN--QCGV-GTVAREDLPGHLKDSCSTA--LVLCPFKDSGCK---H-R-CPKLAM H_sapiens_ENSP00000262395 EGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPN--QCGV-GTVAREDLPGHLKDSCNTA--LVLCPFKDSGCK---H-R-CPKLAM T_nigroviridis_ENSTNIP00000019321 QGVCPQESVYCENKCGARMMRRLLSQHGMAECPKRTQPCKYCGKEFVFDTIQNHQYHCPRFPVQCPN--QCGT-PNIAREDLANHVKDNCGSA--LVLCPFKDAGCK---H-R-CPKLAI G_gorilla_ENSGGOP00000016344 EGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPN--QCGV-GTVAREDLPGHLKDSCNTA--LVLCPFKDSGCK---H-R-CPKLAM E_caballus_ENSECAP00000009502 EGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCAKEFVFDTIQSHQYQCPRLPVPCPN--QCGV-GTVAREDLPGHLKDSCSTA--LVLCPFKDSGCK---H-R-CPKLAM D_rerio_ENSDARP00000013849 QGICPQESVYCENKCGARMMRRLLSQHTMTECPKRTQPCKYCGKEFVYDTIQNHQYHCPRFPVQCPN--QCGT-PNIAREDLANHVKESCGSA--LVLCPFKEAGCK---H-R-CPKMAI B_taurus_ENSBTAP00000050075 EGVCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVPCPN--QCGV-GTVAREDLPGHLKDSCSTA--LVLCPFKDSGCK---H-R-CPKLAM M_musculus_ENSMUSP00000017530 EGVCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCAYCTKEFVYDTIQSHQYQCPRLPVPCPN--QCGV-GTVAREDLPTHLKDSCSTA--FVLCPFKESGCK---H-R-CPKLAM G_aculeatus_ENSGACP00000014759 QGVCPQESVYCENKCGARMMRRLLSQHGLAECPKRTQPCKYCGKEFVFDTIQNHQYHCPRFPVQCPN--QCGT-PNIAREDLANHVKDNCGSA--LVLCPFKDAGCK---H-R-CPKLAI R_norvegicus_ENSRNOP00000018468 EGVCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCAYCTKEFVYDTIQSHQYQCPRLPVPCPN--QCGV-GTVAREDLPTHLKDSCSTA--FVLCPFKESGCK---H-R-CPKLAM T_rubripes_ENSTRUP00000012878 QGVCPQESVYCENKCGARMMRRLLSQHGMAECPKRTQPCKYCSKEFVFDTIQNHQYHCPRFPVQCPN--QCGT-PNIAREDLANHVKDNCGSA--LVLCPFKDAGCK---H-R-CPKLAI O_latipes_ENSORLP00000005579 QGVCPQESVYCENKCGARMMRRLLSQHGMAECPKRTQPCKYCGKEFVFDTIQNHQFHCPRFPVQCPN--QCGT-PNIAREDLANHVKDNCGSA--LVLCPFKDAGCK---H-R-CPKLAI M_domestica_ENSMODP00000024090 EGVCPQESVYCENKCGARMMRRLLGQHMMAECPKRTQPCAYCTKEFVYDTIQNHQHQCPRYPIPCPN--QCGM-GSIPREDLNSHLKENCSTV--PVLCPFKDAGCK---H-R-CPKLAM X_tropicalis_ENSXETP00000056667 QGCCPQESVYCENKCGARMMRRVLSQHSLVECPKRTQPCPYCNKEFVFDTIQSHQYQCPRYPTPCPN--QCGI-ASIAREDLSNHLKDSCSSA--LVLCPFKDSGCK---H-R-GPKITI A_gambiae_AGAP010017-PA AGTCSSEPIYCESKCGTRVLRGRMSIHRAKDCAKRLRRCPHCGREFCADTLAAHGATCPRSPIPCPQ--RCDA-GPFARADLDAHLRDECKAL--TVPCTFKEAGCR---F-K-GPRHLL A_aegypti_AAEL006649-PA AGTCSSEPIYCESKCGTRVVRGRMSIHRAKDCAKRLRRCPHCSREFSADTLSAHGATCPRSPVPCPQ--RCDA-GPFARADLEGHLRDECKAL--SVPCTFKEAGCR---F-K-GPRHLL D_rerio_ENSDARP00000056877 QGVCPEESVYCENKCGARMVRRLLAQHSVSECLKRKLPCRYCKKEFLYDTIQNHQQQCPRFPMQCPN--RCGT-PGITRDTLMAHVKEGCSTA--MVLCPFKEAGCK---H-R-SPKTGV D_melanogaster_FBpp0111838 NGSCGQEPVYCEAKCGQRILRGRMTLHKSKDCAKRLRRCAHCQREFSADTLPLHAAQCPRAPLACPQ--RCDA-GPIPRGELEAHLRDECQSL--AVSCSFKEAGCR---F-K-GPRQML O_anatinus_ENSOANP00000019424 -------------------------------------PCPYCTKEFVFDTIQNHQYQCPRFPLPCPN--QCGT-GAVAREDLPGHLKENCNTA--PVLCPFKDAGCK---H-R-CPKLAM M_domestica_ENSMODP00000024756 D------------------------------------------------------QNCPLATVFCEY---CS--TMLIREQMPNHYDIDCPVA--PIPCTFSTFGCR---E-K-MPRNHL C_intestinalis_ENSCINP00000003738 L------------------------------------------------------KSCIRFPVTCPK--KCGT-KEIPREELNAHLELDCQLA--DKVCPYETVGCT---F-T-CSREKM M_mulatta_ENSMMUP00000021907 D------------------------------------------------------QNCPLANVICEY---CN--TILIREQMPNHYDLDCPTA--PIPCTFSTFGCH---E-K-MQRNHL D_rerio_ENSDARP00000036715 E------------------------------------------------------QFCPFANTVCEY---CE--MELIRDQLALHCDTDCLKA--PVACTFSTFGCR---E-K-MTRNEL M_musculus_ENSMUSP00000004949 D------------------------------------------------------QSCPLANIICEY---CG--TILIREQMPNHYDLDCPTA--PIPCTFSVFGCH---E-K-MQRNHL H_sapiens_ENSP00000316840 D------------------------------------------------------QNCPLANVICEY---CN--TILIREQMPNHYDLDCPTA--PIPCTFSTFGCH---E-K-MQRNHL R_norvegicus_ENSRNOP00000006148 D------------------------------------------------------QSCPLANIICEY---CG--TILIREQMPNHYDLDCPTA--PVPCTFSVFGCH---E-K-MQRNHL P_pygmaeus_ENSPPYP00000003845 D------------------------------------------------------QNCPLANVICEY---CN--TILIREQMPNHYDLDCPTA--PIPCTFSTFGCH---E-K-MQRNHL P_troglodytes_ENSPTRP00000006096 D------------------------------------------------------QNCPLANVICEY---CN--TILIREQMPNHYDLDCPTA--PIPCTFSTFGCH---E-K-MQRNHL O_anatinus_ENSOANP00000018657 D------------------------------------------------------QNCPLASVFCEY---CS--TVLIREQMPTHYDMDCPTA--PIPCTFSSFGCR---E-K-MQRNQL O_cuniculus_ENSOCUP00000010330 D------------------------------------------------------QNCPLANVICEY---CN--TMLIREQMPNHYDLDCPTA--PIPCTFSTFGCH---E-K-MQRNHL G_gorilla_ENSGGOP00000005734 X------------------------------------------------------XXXXXXXXXXXX---XX--XXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXX---X-X-MXRNHL A_carolinensis_ENSACAP00000005007 D------------------------------------------------------GVCLLANVCCEY---CN--TVLIREQLPNHYDNDCPTA--PVPCTYSDFGCP---E-K-MQRNEL T_guttata_ENSTGUP00000010462 D------------------------------------------------------QTCPLANIYCEY---CN--TVLIREQMPNHYDNDCPTA--PVPCFYSAFGCP---E-K-MQRNEL C_familiaris_ENSCAFP00000010159 D------------------------------------------------------QNCPLANVICEY---CN--TMLIREQMPNHYDLDCPTA--PIPCTFSTFGCH---V-K-MQRNHL X_tropicalis_ENSXETP00000016445 D------------------------------------------------------QTCPLAYVTCEY---CQ--TNLIREQMPAHYSMDCTMA--PIPCMYYEFGCT---E-K-MQRNDL B_taurus_ENSBTAP00000021630 E------------------------------------------------------QNCPLANVICEY---CN--TMLIREQMPNHYDLDCPTA--PVPCTFSAFGCH---E-K-MQRNHL E_caballus_ENSECAP00000018618 D------------------------------------------------------QNCPLANVICEY---CN--TMLIREQMPNHYDLDCPTA--PIPCTFNTFGCH---E-K-MQRNHL G_gallus_ENSGALP00000012873 D------------------------------------------------------QTCPLANVFCEY---CN--TMLIRQQMPNHYDNDCPTA--PVPCFYSAFGCP---E-K-MQRNEL T_nigroviridis_ENSTNIP00000012472 E------------------------------------------------------QQCPFASVMCPH---CD--MDLTRDQMESHCDTDCPKA--PIACNFSLFGCK---E-R-MQRHDL T_rubripes_ENSTRUP00000041697 E------------------------------------------------------QQCPFASVMCPY---CD--MDLVRDQMESHCDTDCPIA--PIACTFSLFGCK---E-R-MQRHDL O_latipes_ENSORLP00000001290 E------------------------------------------------------QQCPFASVMCQY---CE--MDLIRDQMESHCDTDCPKA--PIACTFSIFGCK---E-R-MQRHNL M_mulatta_ENSMMUP00000022296 ----------------------------------------------------------------CPNGLYCSV-GTVAQEDLP-HLKDSCSTA--LVLCSFKDSSCK---H-R-CPKWAM M_mulatta_ENSMMUP00000021905 D------------------------------------------------------QNCPLANVICEY---CN--TILIREQ-ASYYDVDCPTA--PIPCTFRTFDCH---E-K-MQRNHL G_aculeatus_ENSGACP00000022648 Q------------------------------------------------------QRCPFAIVKCLF---CD--LELIRDQIESHCDTDCPKA--PIACNFSAFGCK---E-S-MQRHNL C_elegans_F45G2.6 P------------------------------------------------------KTCPQVIISCPF--QCGL-TDRPRLEIEAHCP-SCPNV--DNVCPFVPYGCT---F-A-GGKESI A_gambiae_AGAP000388-PA I-------------------------------------------------------------------------SGLREQLKVGSTQKKTRFQFFLAPNILTDFL---------SPSRQG D_melanogaster_FBpp0074051 Q-------------------------------------------------------------------------RLLVIEQDVGTIRSVLNEEIRQRLHLITDVG-------NIRKQNQV A_gambiae_AGAP003004-PA -------------------------------------------------------------------------------------------------PCPFARVKCK---FVA-PDEAAM A_aegypti_AAEL011363-PA --------------------------------------------------------------------------RIRELELEIVGLRSTLNEEIRQRLALITDIG-------QLKKRTQL D_melanogaster_FBpp0071136 -----------------------------------------------------------------------------------------------EEKCPFAKIKCD---FVGRPETNQL A_aegypti_AAEL015342-PA --------------------------------------------------------------------------RIRELELEIVGLRSTLNEEIRQRLALITDIG-------QLKKRTQL A_carolinensis_ENSACAP00000017602 D------------------------------------------------------KTSDFLNVPYDY-------TSVMHYSKTAFMNGTEPTIVTNIPAFIDVIGQR---M-DFSDSDVL 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000362994 QEHEVTSQTSHLNLLL--GFMKQWKARLGCG--------------LESGPMALEQNLS-DLQLQAAVEVAGDLEVDCYRAPCSESQ----EELALQHFMKEKLLAELEGKLRVFEN---- P_troglodytes_ENSPTRP00000036416 QEHEVTSQTSHLNLLL--GFMKQWKARLGCG--------------LESGPMALEQNLS-DLQLQAAVEVAGDLEVDCYRAPCSESQ----EELALQHFMKEKLLAELEGKLRVFEN---- P_pygmaeus_ENSPPYP00000021917 QEHEVTSQTSHLNLLL--GFMKQWKARLGCG--------------LESGPMALEQNLS-DLQLQAAVEVAGDLEVDCYRAPCSESQ----EELALQHFMKEKLLAELEGKLRVFEN---- M_mulatta_ENSMMUP00000026496 QEHEVTSQTSHLNLLL--GFMKQWKTRLGSG--------------LESGPMALEQNLS-DLQLQAAVEVAGDLEVDCYRAPCSESQ----EELALQHFMKEKLLAELEGKLRVFEN---- E_caballus_ENSECAP00000009372 QEHEVASQATHLNLVL--GFMKQWKAQLGSG--------------LGSGPMALEQNLS-DLQLQAAVEVAGDLEVDCYRAPCSESQ----EELALQHFMKEKLLAELEGKLRVFEN---- B_taurus_ENSBTAP00000041215 EEHEVTSQAAHLNLLL--GFMKQWKAQLGSG--------------LGYGPMALERNLS-DLQLQGAVEVAGDLEVDCYRAPCSESQ----DELALHHFMKEKLLNELEGKLCVFEN---- M_musculus_ENSMUSP00000028234 QEHEATSQSSHLYLLL--AVLKEWKSSPGSN--------------LGSAPMALERNLS-ELQLQAAVEATGDLEVDCYRAPCCESQ----EELALQHLVKEKLLAQLEEKLRVFAN---- O_cuniculus_ENSOCUP00000004916 QEHEATSQASHLNLLL--GFMKQWKAQLGSG--------------LGSGPMALERNLS-DLQLQAAVEVAGDLEVDCYRAPCSESQ----EELALQHLMKEKLLAELEGKLRVFEN---- C_familiaris_ENSCAFP00000031262 QEHEVASQTTHLNLLL--GCVTPWMAPRGPG----------------GAALALERNLS-DLQLQAAVEVAGDLEVDCYRAPRSDSQ----DEHTLQRLTKEKPLAELQEKLRVFEN---- G_gorilla_ENSGGOP00000002249 XXXXXXXXXXXXXXXX--XXXXXXXXXXXXX--------------XXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXVFEN---- M_domestica_ENSMODP00000024498 KEHEASSLSDHLRRLL--ELVIRTKVQAGPS---RGRGASGRRQAAEPEPKAPERNLS-DLQLQGAVEVNGDLEADYFHAASSDSE----EELALQRFMKEKLLSELEEKLRVFEN---- O_anatinus_ENSOANP00000001757 KEHETSSMDMHLGLLL--QAVSQTKANQGDC----------------------------------------------------------EEELALQRFMREKLISDLEEKLHVFEN---- T_guttata_ENSTGUP00000006737 QEHQNSAVGAHMLLLL--QHMRQLQGTL--------------------------------------------------------C-----SKGFSPRPELNKVISELENKLHVFEN---- G_gallus_ENSGALP00000002401 KEHEKAAVGTHMLLLL--QYIKQLKANLCTV-------------------------------------------------------------SKAANGFISQTELNLENKLHVFEN---- D_rerio_ENSDARP00000091948 KEHESCSHAGHLQLLL--DVTRALQRTLNSA---TERVYQDSPVFLEPGPNGSSLAPQ-ADGDIETDGGD-----------------------PGVELAAGQQLDALQQKVQVIEN---- T_nigroviridis_ENSTNIP00000011878 SEHENSSTMEHMRLLL--PIVLSLTQARAEV--------------------------------SDSGEWQEDSVLGLYRAPEEGVH-------VGAGAAASVH-VNLEKKVTALER---- T_rubripes_ENSTRUP00000015632 HDHERAYAYEHLNLLL--HYIMGMKVSMEGL---QPQGLEVAGQKLVELQQSL-RELE-LSVS--TSFTPLPSSVGAALELQLHSE-------KTKVAELGRRCTELEVKANTFEN---- D_rerio_ENSDARP00000069217 QEHEQTSIMEHLRLML--ALLSSMRLRA-----------------------------------EGAGEWQEDVGLGLYRGPEDAPP-------AGAHNVGRGGGPGVQKKVTTLEN---- T_rubripes_ENSTRUP00000047803 REHEHSSTVEHLHLLL--PMVLSLTRTRAEV--------------------------------SESGEWQEDSGLGLYRAPEEGVN-------VGAGAAASVHAVDLEKKVTALEN---- O_latipes_ENSORLP00000020860 HDHERQCSYEHLNLLL--HFIMGIKGVCAAT---LATS-------FTPLHSAMGAALE----------------------LQLQSE-------KTKVAELSRRCQELELKVSTFEN---- T_rubripes_ENSTRUP00000011363 HDHERQCSYEHLNLLL--HFIMGIKISLESL---PPQSLDVASHKLLELHQSL-RDLE----------------------LKLQSE-------KTKVAELSRRCQDLELKVRTFEN---- O_latipes_ENSORLP00000003220 HDHERAFAYEHLNLLL--HYIMGMKVSMEGL---QPQGLETAGHKLVELQKSL-RDLE-ARVSQLSTTSSGP---------------------PVQGAAASSSSSRLEVKSGTFEN---- G_gallus_ENSGALP00000014649 PEHESKCLAEHLYMLL--SFVLSLKSGSGDL---KHLPAIPSSQSSSPLLAANSLCPE--------------------------SE-------LFKSLELLGRCDALEKKTVTFEN---- C_familiaris_ENSCAFP00000028895 QQHEAHWLREHLAMLL--GSLLEAKHLSGAG-----------------------------------------------------GP-------F-LGLKLQQRCEALERKTATFEN---- M_domestica_ENSMODP00000021625 QDHENQKVAEHLCMLL--NFVLEARHFHGDI------------------------------------------------------E-------MSKSTELLERCETLERKTVTFEN---- D_rerio_ENSDARP00000043465 HDHEQACSYEHLNLLL--HFIMGIKVNLESL---QPQSLELASHKIHELHQSL-RELE------------------------------------------LKMGQELELKVNTFEN---- O_latipes_ENSORLP00000008989 SEHEHSSTMEHLRLLL--PMVLSMTRTRLDT--------------------------------SPSGEWQEDSGLGLYRAPDD-----------GCGAAASVPSVDLDKKVSALEN---- T_nigroviridis_ENSTNIP00000016461 HDHERAFAYEHLNLLL--HYIMGMKASRAG-------------------------------------------------------E-------KTKVAELGRRCTELEVKANTFEN---- E_caballus_ENSECAP00000011150 QEHEAKWLQEHLAMLLDSSSFLGQSQVGNPG-----------------------------------------------------AE-------VSKAAELLQRCEALERKTATFEN---- T_guttata_ENSTGUP00000002510 PEHERKCLAEHLYMLM--SSVLSLKTGAGDL----------------------------------------------------------------KPLPLLGRCEALERKTVTFEN---- G_aculeatus_ENSGACP00000022084 GDHEHSSAVEHLRLLL--PLVLS-SVSLAGG--------------------------------DAAGELQEDSGLGLYRAPEEGVA-------TGAGAAASALSLDMEKKVNALEN---- P_pygmaeus_ENSPPYP00000022191 QEHEAQWLREHLAMLL--SSVLEAKPLSGDQ--------------------------------------------------------------SHAGSELLQRCESLENKTATFEN---- M_mulatta_ENSMMUP00000015132 QEHEAQWLREHLAMLL--SSVLEAKPLLGDQ--------------------------------------------------------------SHAGSELLQRCENLEKKTATFEN---- P_troglodytes_ENSPTRP00000036949 QEHEAQWLREHLAMLL--SSVLEAKPLSGDQ--------------------------------------------------------------SHAGSELLQRCESLEKKTATFEN---- M_musculus_ENSMUSP00000109872 QDHELQRLREHLALLL--SSFLEAQASPGTL--------------------------------------------------------------NQVGPELLQRCQILEQKIATFEN---- H_sapiens_ENSP00000247668 QEHEVQWLREHLAMLL--SSVLEAKPLLGDQ--------------------------------------------------------------SHAGSELLQRCESLEKKTATFEN---- G_aculeatus_ENSGACP00000006974 HDHERQCSYEHLNLLL--HFIMGIK-------------------------------------------------------LQLQSE-------KAKVAELSRRCQELELKVGTFEN---- T_nigroviridis_ENSTNIP00000013509 HEHERQCSYEHLNLLL--HFIMGIKSS--------------------------------------------------------RAK-------KTKVAELSRRCQELEVKVSTLEN---- B_taurus_ENSBTAP00000013869 PEHEAQRLQEHLALLL--GVLLEAGRPPGDS-----------------------------------------------------RL-------LLRVAELLQRCEALERKTATFEN---- X_tropicalis_ENSXETP00000042386 KEHYRTSAAAHLSLVC--PLILRIKDNLTNT---EDSTDGPGQKNPF------------SLQAEDFKAGNGDLELDCGHAVGQPSD------------EVANRLSLLETRLQVFEN---- X_tropicalis_ENSXETP00000008559 LEHENKSLAEHLAKGS--PAPPANAPPNNSA----------------------------------------------------------------KVAEMLLKFDTLDKKNTTFEN---- G_aculeatus_ENSGACP00000020860 HDHERAFAYEHLNLLL--HYIMGMKVSMEGL---QPQGLELAGHKLLELQQAL-RELE-ARVSQLSTTSSGP----------------------------PVQCTELEVKAGTFEN---- G_gorilla_ENSGGOP00000004192 KAHEASSAVQHVNLLK--EWSNSLEKKVSLL---QNESVEKNKSIQSLHNQICSFEIE-IERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- H_sapiens_ENSP00000376500 KAHEASSAVQHVNLLK--EWSNSLEKKVSLL---QNESVEKNKSIQSLHNQICSFEIE-IERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- P_troglodytes_ENSPTRP00000011503 KAHEASSAVQHVNLLK--EWSNSLEKKVSLL---QNESVEKNKSIQSLHNQICSFEIE-IERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- P_pygmaeus_ENSPPYP00000007003 KAHEASSAVQHVNLLK--EWSNSLEKKVSLL---QNESVEKNKSIQSLHNQICSFEIE-IERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- G_gallus_ENSGALP00000036699 KAHEASSAVQHVNLLK--EWSNALENKVALL---QNESLEKNKSIQTLHNQICSFEIE-IERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- R_norvegicus_ENSRNOP00000010906 KAHEASSAVQHVNLLK--EWSNSLEKKVSLL---QNESVEKNKSIQSLHNQICSFEIE-IERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- T_guttata_ENSTGUP00000013203 KAHEASSAVQHVNLLK--EWSNALENKVALL---QNESLEKNKSIQTLHNQICSFEIE-IERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- O_anatinus_ENSOANP00000023053 KAHEASSAVQHVNLLK--EWSNSLEKKVSLL---QNESVEKNKSIQSLHNQICSFEIE-IERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- B_taurus_ENSBTAP00000017918 KAHEASSAVQHVNLLK--EWSNSLEKKVSLL---QNESVEKNKSIQSLHNQICSFEIE-IERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- C_familiaris_ENSCAFP00000026713 KAHEASSAVQHVNLLK--EWSNSLEKKVSLL---QNESVEKNKSIQSLHNQICSFEIE-IERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- E_caballus_ENSECAP00000011833 KAHEASSAVQHVNLLK--EWSNSLEKKVSLL---QNESVEKNKSIQSLHNQICSFEIE-IERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- M_musculus_ENSMUSP00000021706 KAHEASSAVQHVNLLK--EWSNSLEKKVSLL---QNESVEKNKSIQSLHNQICSFEIE-IERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- X_tropicalis_ENSXETP00000027864 KAHEASSAVQHVNLMK--EWSNYLEAKVSML---QNESSEKNKSIQILHNQMCSFEIE-IERHKEQLRNNEARIIQLQRVIEGQAD----------------KLKDLDKEIRNLRQ---- M_domestica_ENSMODP00000016701 KTHEASSAVQHVNLLK--EWSNSLEKKVSLL---QNESVEKNKSIQSLHNQICSFEIE-IERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- A_carolinensis_ENSACAP00000000193 KAHETSSAVQHVDLLK--EWSNCLENKVAML---QNESLEKNKSIQTLHNQICSFEIE-IERQKEMLRSNESKIHHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- T_rubripes_ENSTRUP00000013348 RQHESSSAAEHLRMMA--KRNSALESKLDDV---KGELLERFKVLPVLSSRVAELESS-NDELREKNRQTEQKLGTMQKLMSSHSE----------------KLLELELELRSLRG---- D_rerio_ENSDARP00000038596 REHESSFASEHLRMMA--VRNTTLEAKVEDV---KSELMERYKVLPSLSSRLAEVERQ-YEEMREKNRQLEQKLVSMQMLMSSHSE----------------KLLEVEMELRELRP---- T_nigroviridis_ENSTNIP00000005138 RQHESTSAAEHLRMMA--KRNSMLEGKLDDV---KGELLERLKHLPVVSSRVSELENA-SDELREKNRQMEQKLATMQKLMSSHSE----------------KLLEVELELRALRG---- G_aculeatus_ENSGACP00000005703 RQHESTSAGEHLRMIA--NKNSVLENKVEDI---KGELLERYKVLPALSSRLSELENQ-SDELREKNRQVEQKLATMQKLMSSHSE----------------KLLEVELELRSLRV---- C_intestinalis_ENSCINP00000003143 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000015940 QEHERSALRDHMLLVL--EKNFQLEEQISDL---YKSLEQKESKIQQLAEMVKKFEKE-FKQFAQLFGKNGSFLSNMQ-VLASHID----------------KSAWLEVQVRQLLQ---- C_intestinalis_ENSCINP00000001432 -----YSHKILQRQLQ--EMKNAVE-----L---EMRKRESDRDGNVLRANITKLEQR-LTALQRMTAQQTDRSLALKKEVGDNDA----------------ANKRANTE---LTQ---- M_mulatta_ENSMMUP00000015419 KAHEASSAVQHVNLLK--EWSNSLEKKVSLL---QNESVEKNKSIQSLHNQICSFEIE-IERQKEMLRNNESKILHLQRVIDSQAE----------------KLKELDKEIRPFRQ---- M_mulatta_ENSMMUP00000038268 QEHEHSALREHMRLVL--EKNVQLEEQISDL---HKSLEQKESKIQQLAETIKKLEKE-FKQFAQLFGKNGSFLPNIQ-VFASHID----------------KSAWLEAQVHQLLQ---- P_pygmaeus_ENSPPYP00000000253 QEHERSALREHMRLVL--EKNVQLEEQISDL---HKSLEQKESKIQQLAETIKKLEKE-FKQFAQLFGKNGSFLPNIQ-VFASHID----------------KSAWLEAQVHQLLQ---- P_troglodytes_ENSPTRP00000003288 QEHEHSALREHMRLVL--EKNVQLEEQISDL---HKSLEQKESKIQQLAETIKKLEKE-FKQFAQLFGKNGSFLPNIQ-VFASHID----------------KSAWLEAQVHQLLQ---- E_caballus_ENSECAP00000005414 QEHEHSALRDHMLLVL--EKNLQLEKQISDL---HRSLERKESKIQQLTETVNKFEKE-FKQFAQLFGKNGSFLSNIQ-LLASHLD----------------KSAWLEAQVRQLLQ---- C_intestinalis_ENSCINP00000027890 SDYCKSEHDALRSHLA--EISQTL---------------NNLKNSNDVSPEIRKLEVR-LKAIQRMTAQQTDRSLALKKEVGDNDA----------------ANKRANTD---LTQ---- C_familiaris_ENSCAFP00000017853 QEHEHSALRDHMLLVL--EKNLQLEEQISDL---YKSLEQKESKIQQLAETVKKFEKE-FKQFAQLFGKNGSFLSNIQ-VLANHID----------------KSAWLEAQVRQLLQ---- C_intestinalis_ENSCINP00000001022 KAQCEYSHKILQRQLQ--EMKNAVE-----L---EMRKRESDRDGNVLRANITKLEQR-LTALQRMTAQQTDRSLALKKEVGDNDA----------------ANKRANTD---LTQ---- H_sapiens_ENSP00000336825 QQHEHSALREHMRLVL--EKNVQLEEQISDL---HKSLEQKESKIQQLAETIKKLEKE-FKQFAQLFGKNGSFLPNIQ-VFASHID----------------KSAWLEAQVHQLLQ---- O_cuniculus_ENSOCUP00000003184 KAHEASSAVQHVNLLK--EWSNSLEKKVSLL---QNESVEKNKSIQSLHNQICSFEIE-IERQKEMLRNNESKILHLQXXXXXXXX----------------XXXXXXXXXXXXXX---- R_norvegicus_ENSRNOP00000058607 QDHELQRLREHLALLL--SSFLESQASQNQV-----------------------------------------------------------------GPELLQRCQILEQKIATFEN---- M_musculus_ENSMUSP00000082710 LEHERAALQDHMLLVL--EKNYQLEQRVSRI---IEALSRKQTHSQRLPLTAPKKKKE-HPALRPICSVSGTLVSSGK-ALTSHTD----------------KSAWLEAQVRQLLQ---- T_guttata_ENSTGUP00000003276 AEHENSALREHMLQIL--DKNSRLEEQISDL---YKNLEYKEIKIQQLADAIKKCEKE-FRQYTQLFGNNSNLMVSTQ-ALASHLD----------------KSARLESQVKQLIQ---- G_gallus_ENSGALP00000016021 AEHENGALREHMLQIL--DKNSRLEEQISDL---YKSLECKEIKIQQLAEAVKKCEKE-FRQFTQLFGKNSNLMVSTQ-TLASHLD----------------KSARLESQVKQLIQ---- C_intestinalis_ENSCINP00000005981 -----------------------------------------------------------------------------------------------------------IPE---LNQ---- C_intestinalis_ENSCINP00000025605 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000017068 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000013484 REHENAALREHMLLVL--DKNSRLEEKISDL---HRSLEVKELKIQQLAEMVKKFEKE-FRQVMQLFSKNGNLLANTQ-ILANHID----------------KSTWLETQVRQLLH---- A_carolinensis_ENSACAP00000016112 LEHENIYLREHMLQIL--DRNSKLEDQISEL---YKNLEHKEIKIQHLADMVKKCEKE-FRQFTQLYSKNNNLLASTQ-TLAIHID----------------KSACLETQVRQLVQ---- M_domestica_ENSMODP00000003305 KKHENSALREHMLLVL--ERNSRLEEQIFDL---HKNLELKESKIQQLSETVKKFEKE-FRQFVQLFGKNGNLLASTQ-VLASHID----------------KSAWLETQVRELLE---- O_cuniculus_ENSOCUP00000007884 QEHEHSALREHMLLVL--EKNFRLEEQISDL---CKSLEQKESKIQQLAETVKKFEKE-FKQFAQLFGKNGSFLSNIQ-XXXXXXX----------------XXXXXXXXXXXXXX---- A_carolinensis_ENSACAP00000010321 ----------------------------------------------------------------------------------------------------------LESKLRVFEG---- X_tropicalis_ENSXETP00000031605 KEHEDTFLRDHMLYVL--NRNMKLEEQVLGL---QQNLDLKEHQIQQLSDTVKWCEKE-CHQFGQFTGSNGNSLSSTK-TLASYID----------------KSMWLEEQV---IQ---- G_gorilla_ENSGGOP00000006994 QEHEAQWLREHLAMLL--SSVLEAKPLSGDQ--------------------------------------------------------------SHAGSELLQRCESLEKKTATFEN---- O_latipes_ENSORLP00000001368 KLHEEAAVCHHVLLVL--KSSAHLEQQVVFV---QKEALLRQQEVQTDTLLLSDLQEQ-LGSVLQQSRSQEHIVATAQACLDEHRA----------------DILEMENELLAAET---- G_aculeatus_ENSGACP00000025883 KLHEDAAVHRHMLLVL--RSNTHLEQQVEGL---REEALLMQQEVQTDGLLLAGLQKT-IRPLLQQKDGRELTVSAAQVNTYQDSY----------------ILGRFPAFLKVVLS---- D_rerio_ENSDARP00000014326 QVHENTEFSAHVRLVL--EKLCEQTLCSLTM----------QSRVSTFSCDRRSVEEQ------------------------------------------RVRICSVQRELRDLRV---- C_intestinalis_ENSCINP00000027041 NRNESRSLSQPASLET-----------------PDINGQHSNEDIAILNNVPAVLHTD-----------------------------------------LTQKGEEFAREIAQIKE---- P_troglodytes_ENSPTRP00000015252 ARHVEESVKPHLAMMC-------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000009119 ARHVEESVKPHLAMMC-------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000028200 ARHVEESVKPHLAMMC-------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000016271 ARHVEESVKPHLAMMC-------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000262395 ARHVEESVKPHLAMMC-------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000019321 GRHLEDTTKSHLTMMC-------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000016344 ARHVEESVKPHLAMMC-------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000009502 ARHVEESVKPHLAMMC-------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000013849 GRHLEESTKSHLTMMC-------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000050075 ARHVEESVKPHLAMMC-------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000017530 GRHVEESVKPHLAMMC-------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000014759 GRHLEDTTKSHLTMMC-------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000018468 GRHVEESVKPHLAMMC-------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000012878 GRHLEDTTKSHLTMMC-------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000005579 GRHLEDTTKSHLTMMC-------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000024090 GRHMEESVKPHLAMMC-------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000056667 SRHLEENMRAHLSMMS-------------------------------------------------------------------------------------------------------- A_gambiae_AGAP010017-PA EAHLEANTSAHLSLMV-------------------------------------------------------------------------------------------------------- A_aegypti_AAEL006649-PA EAHLESNTSSHLSLMV-------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000056877 ARHLEEAAPTHLSLLC-------------------------------------------------------------------------------------------------------- D_melanogaster_FBpp0111838 EAHLESNAAAHLSLMV-------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000019424 SRHLEDSVKLHLGLTW-------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000024756 ARHLQEDTLAHMRMMA--QAIENISIAAFNPK--LH---QREASSYDTS------------------PLPRTP----------------------------------YPGPQNFQE---- C_intestinalis_ENSCINP00000003738 ATHVDECFRKHVSLLC--DGFRK------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000021907 ARHLQENTQSHMRMLA--QAVHSLSL--------IP------------------------------------DSG-------------------------------YVSEVRNFQE---- D_rerio_ENSDARP00000036715 AQHMQEFTQMHMRYMA--EFLRSQTLNNCTM------PSAAAHLSSDDRG-----------------ASARSPDSCQ-----------------------------CKQELLNLRE---- M_musculus_ENSMUSP00000004949 ARHLQENTQLHMRLLA--QAVHNVNL-ALRP---CD--------------------------------AASPSRG-------------------------------CRPEDPNYEE---- H_sapiens_ENSP00000316840 ARHLQENTQSHMRMLA--QAVHSLSV--------IP------------------------------------DSG-------------------------------YISEVRNFQE---- R_norvegicus_ENSRNOP00000006148 ARHLQENTQLHMRLLA--QAVHNVNL-SLRP---CD--------------------------------ASSPSRG-------------------------------CRPEDPNYEE---- P_pygmaeus_ENSPPYP00000003845 ARHLQENTQSHMRMLA--QAVHSLSL--------IP------------------------------------DSG-------------------------------YISEVRNFQE---- P_troglodytes_ENSPTRP00000006096 ARHLQENTQSHMRMLA--QAVHSLSL--------IP------------------------------------DSG-------------------------------YISEVRNFQE---- O_anatinus_ENSOANP00000018657 ARHLQDDTQAHMRMMA--QALHSISITALTP---VP---QLDVLPFDPA------------------SLPRSSSGY---D--------------------------CHPEVQNFQE---- O_cuniculus_ENSOCUP00000010330 ARHLQEKTQLHMRMLA--QAVHSLNL-ALTP---IP------------------------------------DSG--------------------------------YPEGHNFQE---- G_gorilla_ENSGGOP00000005734 ARHLQENTXSXMRMLA--QAVHSLSL--------IX------------------------------------XSG-------------------------------YISEVRNFQE---- A_carolinensis_ENSACAP00000005007 ARHWQEFTQVHMRMMA--QTLRNVHVTNPAS---GN---F---------------------------HAMPPSCE-------------------------------CSPEVRNFKE---- T_guttata_ENSTGUP00000010462 ARHMQEFTQVHMRMMA--QSFQNISVTAANP---VP---FINGLPFEPALFS---------------HVSHAAYN-------------------------------CNPEVENFKE---- C_familiaris_ENSCAFP00000010159 ARHLQENTQSHMRMLG--QAVQSLSL-ALAP---VP---QRDVPPYDSS------------------SVSRVSST-------------------------------CHPEVQNFQE---- X_tropicalis_ENSXETP00000016445 ARHLQEFTQAHMRMMA--QTLRSFSS-SVTPTSHMPDISFCDPSQFEPAPPSVA-----------TVHSSHTPSQN---D--------------------------CTQETRNLRE---- B_taurus_ENSBTAP00000021630 ARHLQENTQSHMRMMA--QAVQTLSL-AVAP---VP---QCTMPLYDSV------------------PPTRPSSG-------------------------------RHSEVHNFQE---- E_caballus_ENSECAP00000018618 ARHLQENTQSHMRMLA--QAVQSLSL-ALAP---VP---QRDMLPYDSA------------------PLSRVSSG-------------------------------CYPEVRNFQE---- G_gallus_ENSGALP00000012873 ARHMQEFTQVHMRMMA--QSIQNISVTATNP---VP---FINGLPFEPALFS---------------HVSRAPYN-------------------------------CNPEVENFKE---- T_nigroviridis_ENSTNIP00000012472 ARHMQDFTQMHMHYMA--DFLRSLNLNGTIP---KDQGA----------AASAS-----------SCSKGALSSNCTPCQ--------------------------PTEEMQRLR----- T_rubripes_ENSTRUP00000041697 ARHMQDFTQMHMHYMA--DFLRGLNLNGTTP---KPLGAIGHSISFEDHGASAS-----------SCDKGVSSSNCAPCQ--------------------------PNEETQRLR----- O_latipes_ENSORLP00000001290 AQHMQEFTQMHMRYMD--IRMTTLTKKTKTT---KNALIVIYFFFPKICVFLVQLQHRLRGSSTRSAASQLILQSC---EFTLYSH----------------SKRLVKNCFYHLR----- M_mulatta_ENSMMUP00000022296 AWHVEESVKPHLVMMC-------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000021905 SHHLQE-TPCHTRMLT--QAVHSLSL--------IP------------------------------------DSG-------------------------------YISEARNFQE---- G_aculeatus_ENSGACP00000022648 AQHMQEFTQMHMRYMA--EFLRGLSLNGTTP---KSLWAPAPSAYPEDQGATAALAAVCSGP--RGAPSSMSSNSCAPSQ--------------------------PAEGMQRLR----- C_elegans_F45G2.6 QQHLSDEPVRHLMYLC-------------------------------------------------------------------------------------------------------- A_gambiae_AGAP000388-PA TNEWRTDIVNRIDALEKTLFFVNQDRAAIEQEAAVSCLTKQAAALSMGP----------DDGQQPSTSKACQPLALSALN--------------------SAPYHTLPAGSCDSTS---- D_melanogaster_FBpp0074051 VEDWTRETEKAMDDLR----------RQMEEETNRKAFAIEQNQLDVQYCC---DITQSLKEQVESRLDEAQKLVNQLSAD------VTYHQNQLNDNILKLEELIFENERLNREKFFQI A_gambiae_AGAP003004-PA SAHIASDCQQHLQVAR--SPCVSALTVTKFEFSPFTICSYCSRRGSNDRYKFWDP----------------------------------------------------PAKNSVPEMSTNE A_aegypti_AAEL011363-PA GDEWTAKVGDVLNALK----------KCINEETDSRCVDVERCKLDINRLMREYERIEAWRLELTTRINRVGELAGRDEVDKPKDAKLVMIESRL--NYLQTEVETLREEQKDRKG---- D_melanogaster_FBpp0071136 EEHLKADMPHHMQLML--QAFQQTAIATWQPHKPST--SGAAVENGHGQQQLPPP---------------------------------------------------PQYANGVDEQ---- A_aegypti_AAEL015342-PA GDEWTAKVGDVLNALK----------KCINEETDSRCVDVERCKLDINRLMREYERIEAWRLELTTRINRVGELAGRDEVDKPKDAKLVMIESRL--NYLQTEVETLREEQKDRKG---- A_carolinensis_ENSACAP00000017602 KLSRLYNCSSSLSFMGTCSFELANVCGMIQSSNDNADWQRITEISSGPQMDHTYAGVCQETGYFLHFDTRSGNQG---------------------------DQAILESRFLYPKRGFQC 610 620 630 640 650 660 670 680 690 700 710 720 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000362994 IVAVLNKEVEASHLA----LATSIHQSQLD--------------RERILSLEQR--------------------------VVEL-----QQTLAQKDQALGKLEQSL--R--LMEEASFD P_troglodytes_ENSPTRP00000036416 IVAVLNKEVEASHLA----LATSIHQSQLD--------------RERILSLEQR--------------------------VVEL-----QQTLAQKDQALGKLEQSL--R--LMEEASFD P_pygmaeus_ENSPPYP00000021917 IVAVLNKEVEASHLA----LATSIHQSQLD--------------RERILSLEQR--------------------------VVEL-----QQTLAQKDQALGKLEQSL--R--LMEEASFD M_mulatta_ENSMMUP00000026496 IVAVLNKEVEASHLA----LATSIHQSQLD--------------RERILSLEQR--------------------------VVEL-----QQTLAQKDQALGKLEQSL--R--LMEEASFD E_caballus_ENSECAP00000009372 IVAVLNKEVEASHLA----LAASIHQSQLD--------------REHILSLEQR--------------------------VLEL-----QQTLAQKDQALGKLEQSL--R--LMEEASFD B_taurus_ENSBTAP00000041215 IVAVLNKEVEASHLA----LAASIHQSQLD--------------REHILSLEQR--------------------------VLEL-----QQTLAQKDQALGKLEQSL--R--LVEEASYD M_musculus_ENSMUSP00000028234 IVAVLNKEVEASHLA----LAASIHQSQLD--------------REHILSLEQR--------------------------VVEL-----QQTLAQKDQVLGKLEHSL--R--LMEEASFD O_cuniculus_ENSOCUP00000004916 IVAVLNKEVEASHLA----LAASIHQSQLD--------------RERILSLEQR--------------------------VVEL-----QQTLAQKDQALGKLEQSL--R--LMEEASFD C_familiaris_ENSCAFP00000031262 IVAVLNKEVEASHLA----LAASIHQSQLD--------------REHILSLEQQ--------------------------VAKA-----LHLCAVKAQWSVLPLLSH--R--EQEDHSFV G_gorilla_ENSGGOP00000002249 IVAVLNKEVEASHLA----LATSIHQSQLD--------------RERILSLEQR--------------------------VVEL-----QQTLAQKDQALGKLEQSL--R--LMEEASFD M_domestica_ENSMODP00000024498 IVTVLNKEVEASHLA----IAASVHQSGLT--------------QDLILSLEQR--------------------------VVDL-----QQTLTQKDLALTKLEQTL--H--LLEEASYD O_anatinus_ENSOANP00000001757 IVAVLNKEVESSNMA----IAASIHQSNLD--------------RDMILRLEQR--------------------------VLDL-----HQTLAQKDLALARLKQSL--Q--FSELASYD T_guttata_ENSTGUP00000006737 IVAVLNKEVESSNLE----IQAFRRQSELD--------------QNVIRGLELK--------------------------IAEL-----HQCLTQKDAGLSSLHKSL--L--FSEQASYD G_gallus_ENSGALP00000002401 IVAVLNKEVETSNLE----ITAFRRQSELD--------------QNVIRGLELK--------------------------IAEL-----HHCLTQKDAGLSRLHKSL--V--FSEQTSYD D_rerio_ENSDARP00000091948 IISALNREVEKTQIS----VVAMNRDHCNS--------------QQIIQHLEAT--------------------------VAEL-----QQRLVRKDILISSLQQSI--S--AQQDVSYD T_nigroviridis_ENSTNIP00000011878 IVCVLNREVERSTAM----LEAFAHQHALD--------------QEKIENLSTK--------------------------LGQL-----ERVIAMRDLQLSETEQMV--R--ELQSCTYD T_rubripes_ENSTRUP00000015632 VVCVLNREVERFATT----MEASNRQHKLD--------------QDKIEALSNK--------------------------VRQL-----ERTVGLKDLTVAEMEGRL--R--EMSATTFD D_rerio_ENSDARP00000069217 IVCVLNKEVERSALT----MEAISRQHRLD--------------QEKIENLSNK--------------------------VRQL-----ERTLTTRDLQLAESEQSL--R--ELQFCTYD T_rubripes_ENSTRUP00000047803 IICVLNREVERSALK----VEAFAHQHCLD--------------QEKIENLVSK--------------------------VGQL-----ERAIAMRDLQLSETEQMV--R--ELQSCTYD O_latipes_ENSORLP00000020860 IVCILNRELERSCAT----MEAYNRQHRLD--------------QDKIEILSNK--------------------------VRQL-----ERTVSLRDLSIVEMEGKM--K--DMSAATYD T_rubripes_ENSTRUP00000011363 IVCVLNREVERSCTT----MEAYNRQHRLD--------------QDKIEILNNK--------------------------VRQL-----ERTVSLRDLSIVEIDEKM--R--ELSAATYD O_latipes_ENSORLP00000003220 VVCVLNREVERFTTT----MEASNRQHKLD--------------QDKIEALSNK--------------------------VRQL-----ERTVGLKDLTVAEMEGRL--R--EMAATTFD G_gallus_ENSGALP00000014649 IVCVLNREVERVSLT----AEAYSRQHRLD--------------QEQIETLSNK--------------------------VRQL-----ERSIGLKDLAMAEMEEKI--R--NMEASTYD C_familiaris_ENSCAFP00000028895 IVCVLNREVERVAMT----AEACGRQHQLD--------------QDRIEALSNK--------------------------VQQL-----ERTIGLKDLAMAELEQKV--H--EMEASTFD M_domestica_ENSMODP00000021625 IVCVLNREVERVSMT----AEACSRQHRLD--------------QEKIETLSSK--------------------------VQQL-----ERSIGLKDLAMADMEQKI--L--EMEASTYD D_rerio_ENSDARP00000043465 IVCVLNREMERSATT----MEAYNRQHRLD--------------QDKIEILNNKIESNQGIKCEADNSCFSPRNYWMFVQVRQL-----ERTVGLRDLSIVEMEAKM--R--EMSAATYD O_latipes_ENSORLP00000008989 IVCVLNREVERSSLT----LEAFSHQHRLD--------------QEKIENLSNK--------------------------IRQL-----ERSLTVKDLQLSEAEQMV--R--ELQYCTYD T_nigroviridis_ENSTNIP00000016461 VVCVLNREVERFATT----MEASNRQHKLD--------------QDKIEALSNK--------------------------VRQL-----ERTVGLKDLTVAEMEGRL--R--EMSATTFD E_caballus_ENSECAP00000011150 IVCVLNREVERVAMT----AEACGRQHRLD--------------QDRIEALSNK--------------------------VQQL-----ERSIGLKDLAMADLEQKV--H--EMEASTFD T_guttata_ENSTGUP00000002510 IVCVLNREVERVSLT----AEAYSRQHRLD--------------QEKIETLSNK--------------------------VRQL-----ERSIGLKDLAMAEMEEKI--R--NMEASTYD G_aculeatus_ENSGACP00000022084 IVCVLNREVGRNSVT----LEAFSHQHRLD--------------QEKIENLSNK--------------------------LLQL-----ERTVSMKDLQLSATDQLL--K--ELQFCTYD P_pygmaeus_ENSPPYP00000022191 IVCVLNREVERVAMT----AEACSRQHRLD--------------QDKIEALSSK--------------------------VQQL-----ERSIGLKDLAMADLEQKV--L--EMEASTYD M_mulatta_ENSMMUP00000015132 IVCVLNREVERVAMT----AEACSRQHRLD--------------QDKIEALSNK--------------------------VQQL-----ERSIGLKDLAMADLEQKV--L--EMEASTYD P_troglodytes_ENSPTRP00000036949 IVCVLNREVERVAMT----AEACSRQHRLD--------------QDKIEALSSK--------------------------VQQL-----ERSIGLKDLAMADLEQKV--L--EMEASTYD M_musculus_ENSMUSP00000109872 IVCVLNREVERVAVT----AEACSRQHRLD--------------QDKIEALSNK--------------------------VQQL-----ERSIGLKDLAMADLEQKV--S--ELEVSTYD H_sapiens_ENSP00000247668 IVCVLNREVERVAMT----AEACSRQHRLD--------------QDKIEALSSK--------------------------VQQL-----ERSIGLKDLAMADLEQKV--L--EMEASTYD G_aculeatus_ENSGACP00000006974 IACVLNREMERSCST----MEAYNRQHRLD--------------QDKIEILNNK--------------------------VRQL-----ERTVSLRDLSIVEMEGKM--R--DMSAATYD T_nigroviridis_ENSTNIP00000013509 IACVLNREVERSCTT----MDAYNRQHRLD--------------QDKIEILNNK--------------------------VRQL-----ERTVSLRDLSIVEMDEKM--R--ELSAATYD B_taurus_ENSBTAP00000013869 IVCVLNREVERVAVT----AEACGRQHRLD--------------QDRIEALSNK--------------------------VQQL-----ERSIGLKDLAMADLEQKV--L--EMEASTFD X_tropicalis_ENSXETP00000042386 IISVLSKEIDSSQSQ----LAAIKEQKAEE--------------ERKVKALEHK--------------------------VENL-----RCTLAMKDIVLNELEMRS--A--CLEQTSYD X_tropicalis_ENSXETP00000008559 IVSVLNREVERSSHA----AEELARQLRAA--------------QEKVEALTTK--------------------------VRQL-----ERTLGQKELIVAELETRM--Q--ESELSTYD G_aculeatus_ENSGACP00000020860 VVCVLNREVERFATA----MEASNRQHKLD--------------QDKIEALSNK--------------------------VRQL-----ERTVGLKDLTVAEMEGRL--R--EMSATTFD G_gorilla_ENSGGOP00000004192 N---WE---EADSMK----SSVESLQNRVT-ELESVDKSAGQV-ARNTGLLESQ--------------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN H_sapiens_ENSP00000376500 N---WE---EADSMK----SSVESLQNRVT-ELESVDKSAGQV-ARNTGLLESQ--------------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN P_troglodytes_ENSPTRP00000011503 N---WE---EADSMK----SSVESLQNRVT-ELESVDKSAGQV-ARNTGLLESQ--------------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN P_pygmaeus_ENSPPYP00000007003 N---WE---EADSMK----SSVESLQNRVT-ELESVDKSAGQV-ARNTGLLESQ--------------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN G_gallus_ENSGALP00000036699 N---WE---EADSMK----SSVESLQNRVT-ELESVDKTAGQG-ARNTSMLETQ--------------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN R_norvegicus_ENSRNOP00000010906 N---WE---EADSMK----SSVESLQNRVT-ELESVDKSAGQA-ARNTGLLESQ--------------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN T_guttata_ENSTGUP00000013203 N---WE---EADSMK----SSVESLQNRVT-ELESVDKTAGQG-ARNTSLLETQ--------------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN O_anatinus_ENSOANP00000023053 N---WE---EADSMK----SSVESLQNRVT-ELESVDKNAGQA-ARNTGMLETQ--------------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN B_taurus_ENSBTAP00000017918 N---WE---EADSMK----SSVESLQNRVT-ELESVDKSAGQA-ARNTGLLESQ--------------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN C_familiaris_ENSCAFP00000026713 N---WE---EADSMK----SSVESLQNRVT-ELESVDKSAGQA-ARNTGLLESQ--------------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN E_caballus_ENSECAP00000011833 N---WE---EADSMK----SSVESLQNRVT-ELESVDKSAGQA-ARNTGLLESQ--------------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN M_musculus_ENSMUSP00000021706 N---WE---EADSMK----SSVESLQNRVT-ELESVDKSAGQA-ARNTGLLESQ--------------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN X_tropicalis_ENSXETP00000027864 T---GD---EADGMK----SNYESLQNRLS-QLEVMAKNA--A-SWNPGVLETQ--------------------------INRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN M_domestica_ENSMODP00000016701 N---WE---EADSMK----SSVESLQNRVT-ELESVDKSAGQA-ARNTGLLETQ--------------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN A_carolinensis_ENSACAP00000000193 N---WE---EADSMK----SSVESLQNRVT-ELESVDKTAGQG-ARNAGLLESQ--------------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN T_rubripes_ENSTRUP00000013348 L---RD---EVENLR----GTLESVRTRLN-ALEQGGRSGSGS-THTLASLEAQ--------------------------MNRH-----DDMLSVHDIRLADMDLRF--Q--VLETASYN D_rerio_ENSDARP00000038596 LRAMRE---EVETLR----GSVESMRSMVS-SLDSSCVNSASG-SHTLASLEQQ--------------------------LTRH-----DDLMSVHDVRLAEMDLKL--Q--VLETASFN T_nigroviridis_ENSTNIP00000005138 L---RD---EVENLR----GSLEGFRTRLS-ALEQGGRGGSGS-THTLASLEAQ--------------------------MNRH-----DDMLSVHDIRLADMDLRF--Q--VLETASYN G_aculeatus_ENSGACP00000005703 L---RD---EVENLR----GTLENVRTRLN-TLEQGGRSGTGSTTHTLATLENQ--------------------------LKRH-----DEMLSVHEIRLADMDLRF--Q--VLETASYN C_intestinalis_ENSCINP00000003143 ---------------------------------------------MAPENLSQM--------------------------VDAF-----ERQLGMYDVRIADMDQRF--Q--VIETTSYS B_taurus_ENSBTAP00000015940 MANQQQSKFDLKPLV----EAIDTVKQKIT-LLETN--------DQRLVVLEGE--------------------------TNKH-----DAHINIHKAQLNKNEERF--K--LLESACYN C_intestinalis_ENSCINP00000001432 K---VE---EIGREI----AQIKEKQNELKRKLESTSSSR--E-QIAPENLSQM--------------------------VDAF-----ELQLGMYDVRIADMDQRF--Q--VIETTSYS M_mulatta_ENSMMUP00000015419 N---WE---EADSMK----SSVESLQNRVT-ELESVDKSAGQV-ARNTGLLESQ--------------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN M_mulatta_ENSMMUP00000038268 MVNQQQNKFDLRPLM----EAVDTVKQKIT-LLENN--------DQRLAVLEEE--------------------------TNKH-----DTHINIHKAQLNKNEERF--K--LLEGTCYN P_pygmaeus_ENSPPYP00000000253 MVNQQQNKFDLRPLM----EAVDTVKQKIT-LLENN--------DQRLAVLEEE--------------------------TNKH-----DTHINIHKAQLSKNEERF--K--LLEGTCYN P_troglodytes_ENSPTRP00000003288 MVNQQQNKFDLRPLM----EAVDTVKQKIT-LLENN--------DQRLAVLEEE--------------------------TNKH-----DTHINIHKAQLSKNEERF--K--LLEGTCYN E_caballus_ENSECAP00000005414 MANQQETKFDLRALM----EAIDTVKQKIT-LLETH--------DQRIVVLEGE--------------------------TNKH-----DVHINIHKAQLNKNEERF--K--LLEGACYN C_intestinalis_ENSCINP00000027890 K---VE---EIAREI----AQIKEKQNELERNIESTSGSR--E-QMAPENLSQM--------------------------VDAF-----ERQLGMYDVRIADMDQRF--Q--VIETTSYS C_familiaris_ENSCAFP00000017853 MANQQQNKFDLRPLV----EAIDTVKQKIT-LLETN--------DQRLVVLEGE--------------------------TNKH-----DAHINIHKAQLNKNEERF--K--LLEGACYN C_intestinalis_ENSCINP00000001022 K---VE---EIAREI----AQIKEKQNELERKIESTSSSR--E-QMAPENLSQM--------------------------VDAF-----ERQLGMYDVRIADMDQRF--Q--VLETTSYS H_sapiens_ENSP00000336825 MVNQQQNKFDLRPLM----EAVDTVKQKIT-LLENN--------DQRLAVLEEE--------------------------TNKH-----DTHINIHKAQLSKNEERF--K--LLEGTCYN O_cuniculus_ENSOCUP00000003184 X---XX---XXXXXX----XXXXXXXXXXX-XXXXXXXXXXXX-XXXXXLLESQ--------------------------LSRH-----DQMLSVHDIRLADMDLRF--Q--VLETASYN R_norvegicus_ENSRNOP00000058607 IVCVLNREVERVAVT----AEACSRQHRLD--------------QDKIEALSNK--------------------------VQQL-----ERSIGLKDLAMADLEQKV--S--ELEVSTYD M_musculus_ENSMUSP00000082710 IVNQQPSRLDLRSLV----DAVDSVKQRIT-QLEAS--------DQRLVLLEGE--------------------------TSKH-----DAHINIHKAQLNKNEERF--K--QLEGACYS T_guttata_ENSTGUP00000003276 MANQQQSKLDLQPLL----DTIENVKQKIA-LMETY--------DQRLVVLEDQ--------------------------SSKH-----DLQINIHKAQLNKNEERF--K--LLEGTCYN G_gallus_ENSGALP00000016021 MANQQQSKLDLRPLF----DTIENVKQKIA-LMETY--------DQRLAVLESQ--------------------------SSKH-----DLQINIHKAQLNKNEERF--K--LLEGTCYN C_intestinalis_ENSCINP00000005981 K---LK---EMIEEM----TRIRQKQNELERKL----STR--N-QENEQNFLAQ--------------------------INGF-----EQQIGLYDVRIADMDQRF--Q--VLETTSYS C_intestinalis_ENSCINP00000025605 ------------------------------------------------------------------------------------------------------MDQRF--Q--VLETTSYS A_carolinensis_ENSACAP00000017068 --------------------------------------------------------------------------------VEQQ-----DSLLAVKDVMISNLASRI--H--TLEQTTYD O_anatinus_ENSOANP00000013484 MANQQQSKFDLKSLM----ETIDTVKQKIA-LLETY--------DQRLVVLKDQ--------------------------TRQH-----DAHINAHKAQLNKNEERF--K--LLEGTCYN A_carolinensis_ENSACAP00000016112 MANQQQSKFDLRPLL----ETVENIKQKVA-FLESY--------EQRLVVLEDL--------------------------SSQH-----DIHLGLHKAQLNKNEERF--K--LLEGTSYN M_domestica_ENSMODP00000003305 LANQQENKLDLKPLI----NTIDTIKQKIT-LLETY--------DQRLVTLEGQ--------------------------TNRH-----DVHINVHKAQLNKNEERF--K--MLEGTCYN O_cuniculus_ENSOCUP00000007884 XXXXXXXXXXXXXXX----XXXXXXXXXXX-XXXXX--------XXXXXVLEGE--------------------------TSKH-----DAHINIHKAQLNKNEERF--K--LLEGACYN A_carolinensis_ENSACAP00000010321 IASVLSKEMAVSRQK----SAAVRGQRGLD--------------QDMIRGLELK--------------------------MADL-----QRCLVQKDAALCKLEERL--R--SSEEISYD X_tropicalis_ENSXETP00000031605 LVSKEHSRLDLRPIL----DTLESTKQRLS-TLEAY--------KDRIDNLDGQ--------------------------FKKH-----DVLLSNHKMQMTSNEERF--R--LVEGTSYN G_gorilla_ENSGGOP00000006994 IVCVLNREVERVAMT----AEACSRQHRLD--------------QDKIEALSSK--------------------------VQQL-----ERSIGLKDLAMADLEQKV--L--EMEASTYD O_latipes_ENSORLP00000001368 ----------LREHIGNQTGNSRSVKLRSA-TLCTGVFLFYIKCHLMSATLEEN--------------------------RKRH-----SGLLELHVAQLALNKQHL--Q--ELELTSYD G_aculeatus_ENSGACP00000025883 LLSRGSFELEELRKS----VDAVIQEVSAAEAL-----------RRHLGTLEED--------------------------LKQH-----SGLLDLHAAQLGGNERHL--R--ELGGASFD D_rerio_ENSDARP00000014326 LGSELKEELPRL--------------------------------QASLDSLRQQ-----------------------------------VAVTESLREHLVALKQHS--T--FLESSSYD C_intestinalis_ENSCINP00000027041 KQHVLERKNESISSS----RE-----------------------QMTPESLSQM--------------------------VDAF-----ERQLGMYDVRIAEMDRRF--Q--ILETTSYS P_troglodytes_ENSPTRP00000015252 -------------------------------------------------ALVSR-----------------------------------------QRQELQELRREL--E--EL-SVGSD P_pygmaeus_ENSPPYP00000009119 -------------------------------------------------ALVSR-----------------------------------------QRQELQELRREL--E--EL-SVGSD M_mulatta_ENSMMUP00000028200 -------------------------------------------------ALVSR-----------------------------------------QRQELQELRREL--E--EL-SVGSD B_taurus_ENSBTAP00000016271 -------------------------------------------------ALVSR-----------------------------------------QRQELQELRREL--E--EL-SVGSD H_sapiens_ENSP00000262395 -------------------------------------------------ALVSR-----------------------------------------QRQELQELRREL--E--EL-SVGSD T_nigroviridis_ENSTNIP00000019321 -------------------------------------------------NLVGR-----------------------------------------QRQEILELRREM--E--EL-SVSHD G_gorilla_ENSGGOP00000016344 -------------------------------------------------ALVSR-----------------------------------------QRQELQELRREL--E--EL-SVGSD E_caballus_ENSECAP00000009502 -------------------------------------------------ALVSR-----------------------------------------QRQELQELRREL--E--EL-SVGSD D_rerio_ENSDARP00000013849 -------------------------------------------------SLVGR-----------------------------------------QRQEILELRREM--E--EL-SVSHD B_taurus_ENSBTAP00000050075 -------------------------------------------------ALVSR-----------------------------------------QRQELQELRREL--E--EL-SVGSD M_musculus_ENSMUSP00000017530 -------------------------------------------------ALVSR-----------------------------------------QRQELQELRREL--E--EL-SIGSD G_aculeatus_ENSGACP00000014759 -------------------------------------------------NLVGR-----------------------------------------QRQEILELRREM--E--EL-SVSHD R_norvegicus_ENSRNOP00000018468 -------------------------------------------------ALVSR-----------------------------------------QRQELQELRREL--E--EL-SVGSD T_rubripes_ENSTRUP00000012878 -------------------------------------------------NLVGR-----------------------------------------QRQEILELRREM--E--EL-SVGHD O_latipes_ENSORLP00000005579 -------------------------------------------------NLVSR-----------------------------------------QRQEILELRREM--E--EL-SVSHD M_domestica_ENSMODP00000024090 -------------------------------------------------ALVSR-----------------------------------------QRQELQELRRDV--E--EL-SVGCD X_tropicalis_ENSXETP00000056667 -------------------------------------------------SLVSR-----------------------------------------QRQEILELRKQV--E--EL-SVSSE A_gambiae_AGAP010017-PA -------------------------------------------------ALSGR-----------------------------------------QGQQINMLKSAM--A--KL-STNYT A_aegypti_AAEL006649-PA -------------------------------------------------ALSGR-----------------------------------------QGQQINMLKNAM--A--KL-STNYT D_rerio_ENSDARP00000056877 -------------------------------------------------GLVNR-----------------------------------------QRLELRDLRRRM--E--EL-SGSRD D_melanogaster_FBpp0111838 -------------------------------------------------ALSSR-----------------------------------------QGQQIQMLKSAV--S--KL-SINYT O_anatinus_ENSOANP00000019424 -------------------------------------------------ALVSR-----------------------------------------QRQELQELRRDV--E--EL-AAGSD M_domestica_ENSMODP00000024756 TIQQLESRLVIQDHQ--------------------------------IRELTAK--------------------------METQ-----SACVGDLKRTIRTLEDRI--A--EMEAQQCN C_intestinalis_ENSCINP00000003738 --------------------------------------------QAELLGLQKK-------------------------------------QLFEHKQILHDHGKMV--RNGIFSNIEFD M_mulatta_ENSMMUP00000021907 TIHQLEGRLVRQDHQ--------------------------------IRELTAK--------------------------METQ-----STYVSELKRTIRTLEDKV--A--EIEAQQCN D_rerio_ENSDARP00000036715 TVLELEGRLVRQDQQ--------------------------------IRELCIH--------------------------NDTQ-----KNQVTELRRKLVSLEEST--R--ELEAQQYQ M_musculus_ENSMUSP00000004949 TIKQLESRLVRQDHQ--------------------------------IRELTAK--------------------------METQ-----SMYVGELKRTIRTLEDKV--A--EMEAQQCN H_sapiens_ENSP00000316840 TIHQLEGRLVRQDHQ--------------------------------IRELTAK--------------------------METQ-----SMYVSELKRTIRTLEDKV--A--EIEAQQCN R_norvegicus_ENSRNOP00000006148 TVKQLEGRLVRQDHQ--------------------------------IRELTAK--------------------------METQ-----SMHVSELKRTIRSLEDKV--A--EMEAQQCN P_pygmaeus_ENSPPYP00000003845 TIHQLEGRLVRQDHQ--------------------------------IRELTAK--------------------------METQ-----SMYVSELKRTIRTLEDKV--A--EIEAQQCN P_troglodytes_ENSPTRP00000006096 TIHQLEGRLVRQDHQ--------------------------------IRELTAK--------------------------METQ-----SMYVSELKRTIRTLEDKV--A--EIEAQQCN O_anatinus_ENSOANP00000018657 TIQQLEGRLVRQDHQ--------------------------------IRELIAK--------------------------METQ-----SSHVVDLKRTIRTLEDKI--A--EMEAQQCN O_cuniculus_ENSOCUP00000010330 TIQQLEGRLVRQDHQ--------------------------------IRELTAK--------------------------METQ-----SMYVSELKRTIRTLEDKV--A--EIEAQQCN G_gorilla_ENSGGOP00000005734 XIHQLEGRLVRQXHQ--------------------------------IRELTXK--------------------------METQ-----SMYVSELKRTIRTLEDKV--A--EXEAQQCN A_carolinensis_ENSACAP00000005007 TIQQLEGRLVRQDHQ--------------------------------IRELIAK--------------------------METQ-----NSQVGDLKGTIKNLEEKI--T--ELEAQQCN T_guttata_ENSTGUP00000010462 TIQQLEGRLVRQDHQ--------------------------------IRELIAK--------------------------METQ-----NTHMAELKRTIRNLEGKI--T--EMEAQQCN C_familiaris_ENSCAFP00000010159 TIQQLEGRLVRQDHQ--------------------------------IRELTAK--------------------------METQ-----SMHVSELKRNIRTLEDKV--A--EIEAQQCN X_tropicalis_ENSXETP00000016445 TIEQLEGRLVRQDHQ--------------------------------IRELIAK--------------------------METQ-----CTYVNELKHTIRSLDNRL--G--EMESQQCS B_taurus_ENSBTAP00000021630 TIQQLEGRLVRQDHQ--------------------------------IRELTAK--------------------------METQ-----SMYVNELKRTIRTLEDKV--A--EIEAQQCN E_caballus_ENSECAP00000018618 TIQQLEGRLVRQDHQ--------------------------------IRELTAK--------------------------METQ-----SIYVSELKRTIRTLEDKV--A--EIEAQQCN G_gallus_ENSGALP00000012873 TIQQLEGRLVRQDHQ--------------------------------IRELIAK--------------------------METQ-----NTHMAELKRTIRDLEGKI--T--EMEAQQCN T_nigroviridis_ENSTNIP00000012472 ---EMDRRLVKQDHQ--------------------------------LRELIIL--------------------------KENQ-----TGQIAELRKRVSVLEESM--R--ELESQHCT T_rubripes_ENSTRUP00000041697 ---EMDRRLVKQDHQ--------------------------------LRELIIL--------------------------KETQ-----AGQLAELGRRVSMLEETV--R--ELESQHCT O_latipes_ENSORLP00000001290 NVAKLKPMLTRSDLELIIDSVKCFKAQGFPSLVKCQNILKTPKTQFSLEWVLRH--------------------------KDRKSNHKLAGQLAELRRRVSVLEETV--K--ELEAQQYH M_mulatta_ENSMMUP00000022296 -------------------------------------------------ALLIW-----------------------------------------QWQELQDLQQEL--E--DL-SVGSD M_mulatta_ENSMMUP00000021905 TSHQLEDRLVGQDNQ--------------------------------IQELTDE--------------------------IETQ-----SIYVSE----IRTLEDKV--A--DIEAQQCN G_aculeatus_ENSGACP00000022648 ---EMDGRLVKQDHQ--------------------------------LRELIIL--------------------------KETQ-----AGQLAELRRRVSLLEDTV--K--ELESQQCH C_elegans_F45G2.6 ---------------------------------------------DEITDLKGT--------------------------YELM-----ERDMGSFNDRQTRILSAA-----ETCTEMFG A_gambiae_AGAP000388-PA SSSSMEPVVEVKGPIKEILDDIHKYQVKLNYNQKDITIRLFEC-EERMVELENT--------------------------LKKC-----RRETYHTKQRTEELQTNMLMANNRGTPASEN D_melanogaster_FBpp0074051 EEFLQQINEDIKTKLG-NSDYVTSKQATLDYEVKNVKNIVCET-EERCDKL--------------------------------------DRALHQTMQNISDLETQMAMQQRIASVQNIR A_gambiae_AGAP003004-PA LVRSM---------------------------------------YERIVILEQE--------------------------VHIL-----GIKLSKQEIQLTKLNQ-------EVDPRYSG A_aegypti_AAEL011363-PA DEKAQEGNELVKGKIG-VGDEQLDKQAKLDYELKGVLNTVNET-ED---SLEKY-----------------------------------RRETYYTKQSLDDLQVHLQHQEKLVVIQNTE D_melanogaster_FBpp0071136 IVQTM---------------------------------------YQRIVVLEQR--------------------------TREQ-----ETRLENMQKQLRLARQQA-----PVDPRYSN A_aegypti_AAEL015342-PA DEKAQEGNELVKGKIG-VGDEQLDKQAKLDYELKGVLNTVNET-EDK--SLEKY-----------------------------------RRETYYTKQSLDDLQVHLQHQEKLVVIQNTE A_carolinensis_ENSACAP00000017602 LQFFYYNSGSETDELNIGVKEYTDANPNGTYRL-----------IETIQGLPVN-----------------------------------YWQLHHISLTMSSKSRVV--FEGIKGSTASN 730 740 750 760 770 780 790 800 810 820 830 840 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000362994 -G---------------TFLWKITNVTRRCHESACGRT--VSLFSPAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI--VIMRGEYDALLPWPFRNK---VTFMLLDQN----NR--- P_troglodytes_ENSPTRP00000036416 -G---------------TFLWKITNVTRRCHESACGRT--ISLFSPAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI--VIMRGEYDALLPWPFRNK---VTFMLLDQN----NR--- P_pygmaeus_ENSPPYP00000021917 -G---------------TFLWKITNVTRRCHESACGRT--VSLFSPAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI--VLMRGEYDALLPWPFRNK---VTFMLLDQN----NR--- M_mulatta_ENSMMUP00000026496 -G---------------TFLWKITNVTRRCHESACGRT--VSLFSPAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI--VIMRGEYDALLPWPFRNK---VTFMLLDQN----NR--- E_caballus_ENSECAP00000009372 -G---------------TFLWKITNVTRRCHESACGRT--VSLFSPAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI--VIMRGEYDALLPWPFRNK---VTFMLIDQN----NR--- B_taurus_ENSBTAP00000041215 -G---------------TFLWKITNVTRRCHESACGRT--VSLFSPAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI--VIMRGEYDALLPWPKKGE---VTFMLLDQN----NR--- M_musculus_ENSMUSP00000028234 -G---------------TFLWKITNVTKRCHESVCGRT--VSLFSPAFYTAKYGYKLCLRLYLNGDGSGK-KTHLSLFI--VIMRGEYDALLPWPFRNK---VTFMLLDQN----NR--- O_cuniculus_ENSOCUP00000004916 -G---------------TFLWKITNVTRRCLESACGRT--VSLFSPAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI--VIMRGEYDALLPWPFRNK---VTFMLLDQN----NR--- C_familiaris_ENSCAFP00000031262 WA---------------RSWWKITNVTFRCHESACGRT--VSLFSPAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI--VIMRGEYDALLPWPFRNK---VTFMLLDQN----NR--- G_gorilla_ENSGGOP00000002249 -G---------------TFLWKITNVTRRCHESACGRT--VSLFSPAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI--VIMRGEYDALLPWPFRNK---VTFMLLDQN----NR--- M_domestica_ENSMODP00000024498 -G---------------VYLWKITNFTRRCHESACGRT--VSLFSPAFYTARYGYKLCLRIYLNGDGMGK-GTHLSLFI--VVMKGKYDALLEWPFRNKAIPVTFMLLDQN----NR--- O_anatinus_ENSOANP00000001757 -G---------------IYLWKITDFSRKCHESLCGRT--TSLFSPVFYTARYGYKVCLRVYLNGDGTGK-GTHISLFF--VIMKGEYDSLLQWPFRNK---VTFMLLDQN----NR--- T_guttata_ENSTGUP00000006737 -G---------------IFLWKITEVARKLQDSVTGRT--VSLYSPAFYTAKYGYKVCLRVYLNGDGTGK-GTHMSLFF--VVMKGDYDALLPWPFRHK---VTFMLLDQN----NR--- G_gallus_ENSGALP00000002401 -G---------------VFLWKITDVNQKLQDSVTGRV--VSLYSPAFYTAKYGYKVCLRIYLNGDGMGK-GTHVSLFF--VVMKGDYDALLPWPFRHK---VTFMLLDQN----NR--- D_rerio_ENSDARP00000091948 -G---------------TFYWRVCDVSQKQREAANSQK--ISQYSPAFYTARYGFKVCLRLYLNGDGAGK-GSHISLFF--VIMKGEYDPILSWPFKHK---VTFFLLDQN----QR--- T_nigroviridis_ENSTNIP00000011878 -G---------------IFVWKISEFSRRRQEAVAGRT--PAMFSPAFYSSKYGYKMCLRLYLNGDGTGR-GTHLSLFF--VVMKGKCDALLKWPFSQK---VTLMLLDQN----NR--- T_rubripes_ENSTRUP00000015632 -G---------------VFVWRISDFAKKRQDAIAGRA--PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GSHLSLFF--VVMRGQSDALLKWPFNQK---VTLMLLDQS----NR--- D_rerio_ENSDARP00000069217 -G---------------VFIWKIAEFSRRRQDAVAGRA--PAMFSPAFYSSKYGYKMCLRLYLNGDGTGR-GSHLSLFF--VVMKGKYDALLKWPFSQK---VTLMLLDQN----NR--- T_rubripes_ENSTRUP00000047803 -G---------------IFVWKISEFSRRRQEAVAVRM--PTMFSPAFYSSKYGYKMCLRLYLNGDGTGR-GTHLSLFF--VVMRGKCDALLKWPFSQK---VTLMLLDQN----NR--- O_latipes_ENSORLP00000020860 -G---------------IFIWKISDFTKKRQDAMAGRA--PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFF--VVMRGHSDALLKWPFNQK---VTLMLLDQN----NR--- T_rubripes_ENSTRUP00000011363 -G---------------VFVWKISDFTKKRQDAVAGRA--PAMFSSAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFF--VVMRGHSDALLKWPFNQK---VTLMLLDQN----NR--- O_latipes_ENSORLP00000003220 -G---------------VFIWRISDFAKKRQDAVAGRA--PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFF--VVMRGLSDALLKWPFNQK---VTLMLLDQS----NR--- G_gallus_ENSGALP00000014649 -G---------------VFIWKITEFARKRQEAITGRS--PAIFSPAFYTSKYGYKMCLRVYLNGDGTGR-GTHLSLFF--VVMKGPNDALLRWPFNQK---VTLMLLDQN----NR--- C_familiaris_ENSCAFP00000028895 -G---------------VFIWKISDFARKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLRIYLNGDGTGR-GTHLSLFF--VVMKGPNDALLRWPFNQK---VTLMLLDQN----NR--- M_domestica_ENSMODP00000021625 -G---------------IFIWKITDFARKRQEAMAGRS--PAIFSPAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFF--VVMKGPNDALLRWPFNQK---VTLMLLDQN----NR--- D_rerio_ENSDARP00000043465 -G---------------VFVWKISDFSKKRQDAVAGRA--PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFF--VVMRGHSDALLKWPFNQK---VTLMLLDQN----NR--- O_latipes_ENSORLP00000008989 -G---------------IFVWKITDFSHRRQEAVSGRA--PAMFSPAFYSSKYGYKMCLRLYLNGDGTGR-GTHLSLFF--VVMRSKYDALLKWPFSQK---RTIWAASKP----NR--- T_nigroviridis_ENSTNIP00000016461 -G---------------VFVWRISDFAKKRQDAIAGRA--PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GSHLSLFF--VVMRGQSDALLKWPFNQK---VTLMLLDQS----NR--- E_caballus_ENSECAP00000011150 -G---------------VFIWKISDFTRKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLRIYLNGDGTGR-GTHVSLFF--VVMKGPNDALLRWPFNQK---VTLMLLDQN----NR--- T_guttata_ENSTGUP00000002510 -G---------------VFIWKITEFARKRQEAITGRS--PAIFSPAFYTSKYGYKMCLRVYLNGDGTGR-GTHLSLFF--VVMKGPNDALLRWPFNQK---VTLMLLDQN----NR--- G_aculeatus_ENSGACP00000022084 -G---------------IFVWKISDFSRRRQDAVAGRT--PAMFSPAFYSSKYGYKMCLRLYLNGDGTGR-GTHLSLFF--VVMRGKCDALLKWPFSQK---VTLMLLDQN----NR--- P_pygmaeus_ENSPPYP00000022191 -G---------------VFIWKISDFARKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLRIYLNGDGTGR-GTHLSLFF--VVMKGPNDALLRWPFNQK---VTLMLLDQN----NR--- M_mulatta_ENSMMUP00000015132 -G---------------VFIWKISDFARKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLRIYLNGDGTGR-GTHLSLFF--VVMKGPNDALLRWPFNQK---VTLMLLDQN----NR--- P_troglodytes_ENSPTRP00000036949 -G---------------VFIWKISDFARKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLRIYLNGDGTGR-GTHLSLFF--VVMKGPNDALLRWPFNQK---VTLMLLDQN----NR--- M_musculus_ENSMUSP00000109872 -G---------------VFIWKISDFTRKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLRVYLNGDGTGR-GTHLSLFF--VVMKGPNDALLQWPFNQK---VTLMLLDHN----NR--- H_sapiens_ENSP00000247668 -G---------------VFIWKISDFARKRQEAVAGRI--PAIFSPAFYTSRYGYKMCLRIYLNGDGTGR-GTHLSLFF--VVMKGPNDALLRWPFNQK---VTLMLLDQN----NR--- G_aculeatus_ENSGACP00000006974 -G---------------IFVWKISDFTKKRQDAVAGRA--PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFF--VVMRGHSDALLKWPFNQK---VTLMLLDQN----SR--- T_nigroviridis_ENSTNIP00000013509 -G---------------VFVWKIADFTKKRQDAVAGRA--PAMFSPAFYTSKYGYKMC-RIYLNGDGTGR-GSHLSLFF--VVMRGHSDALLKWPFNQK---VTLMLLDQN----NR--- B_taurus_ENSBTAP00000013869 -G---------------VFIWKISDFSRKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLRAYLNGDGTGR-GTHLSLFF--VLMRGPHDALLRWPFNQK---VTLMLLDQN----NR--- X_tropicalis_ENSXETP00000042386 -G---------------VFLWKISDLTNKSHDAVTGRA--ISLYSPVSPSFK-GKSIPSLFPVSLSFKGK-STPHCFLFHPVSRRSQSPSLFPVSLSFK---VTFVLVDHN----NR--- X_tropicalis_ENSXETP00000008559 -G---------------VFIWKISEFGKKRQDAINGRC--PAMFSPPFYTNKYGYKMCLRIYLNGDGTGR-NTHLSLFF--VVMKGNNDALLRWPFNQK---VTLMLLDQN----NR--- G_aculeatus_ENSGACP00000020860 -G---------------VFVWRISDFAKKRQDAIAGRA--PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GSHLSLFF--VVMRGLSDALLKWPFNQK---VTLMLLDQS----NR--- G_gorilla_ENSGGOP00000004192 -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----SS--- H_sapiens_ENSP00000376500 -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----SS--- P_troglodytes_ENSPTRP00000011503 -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----SS--- P_pygmaeus_ENSPPYP00000007003 -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----SS--- G_gallus_ENSGALP00000036699 -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----PS--- R_norvegicus_ENSRNOP00000010906 -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----SS--- T_guttata_ENSTGUP00000013203 -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----PS--- O_anatinus_ENSOANP00000023053 -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----SS--- B_taurus_ENSBTAP00000017918 -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----SS--- C_familiaris_ENSCAFP00000026713 -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----SS--- E_caballus_ENSECAP00000011833 -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----SS--- M_musculus_ENSMUSP00000021706 -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----SS--- X_tropicalis_ENSXETP00000027864 -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VSLMLMDQG----PS--- M_domestica_ENSMODP00000016701 -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----SS--- A_carolinensis_ENSACAP00000000193 -G---------------ILIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----PS--- T_rubripes_ENSTRUP00000013348 -G---------------TLIWKIRDYKRRKQEAVAAKT--LSLYSQPFYTGYFGYKMCARIYLNGDGMGK-GTHLSLFF--VVMRGEYDALLPWPFKQK---VTLMLMDQG----PL--- D_rerio_ENSDARP00000038596 -G---------------TLIWKIRDYKRRKQEAVVSKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF--VVMRGEYDALLQWPFKQK---VTLMLMDQG----PA--- T_nigroviridis_ENSTNIP00000005138 -G---------------TLIWKIRDYKRRKQEAVAAKT--LSLYSQPFYTGYFGYKMCARIYLNGDGMGK-GTHLSLFF--VVMRGEYDALLPWPFKQK---VTLMLMDQG----PL--- G_aculeatus_ENSGACP00000005703 -G---------------TLIWKIRDYKRRKQEAVGAKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF--VVMRGEYDALLPWPFKQK---VTLMLMDQG----PL--- C_intestinalis_ENSCINP00000003143 -G---------------VVIWKIRDFSRRKREAVSGRT--LSLYSQPFYTSRYGYKMCARVYLNGDGMGK-GTHMSLFF--VVMKGEYDALLPWPFRQK---VTLMLLDQG----MD--- B_taurus_ENSBTAP00000015940 -G---------------KLIWKVTDYKLKKKEALDGHT--VSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYF--VVMRGEFDSLLQWPFRQR---VTLMLLDQS----GK--- C_intestinalis_ENSCINP00000001432 -G---------------FLIWKIRDFSRRKREAVSGRT--LSLYSQPFYTSRYGYKMCARVYLNGDGMGK-GTHMSLFF--VVMKGEYDALLPWPFRQK---VTLMLLDQG----MD--- M_mulatta_ENSMMUP00000015419 -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----SS--- M_mulatta_ENSMMUP00000038268 -G---------------KLIWKVTDYKMKKREAVDGHT--VSIFSQSFYTGRCGYRLCARAYLNGDGSGK-GTHLSLYF--VVMRGEFDSLLQWPFRQR---VTLMLLDQS----GK--- P_pygmaeus_ENSPPYP00000000253 -G---------------KLIWKVTDYKMKKREAVDGHT--VSIFSQSFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYF--VVMRGEFDSLLQWPFRQR---VTLMLLDQS----GK--- P_troglodytes_ENSPTRP00000003288 -G---------------KLIWKVTDYKMKKREAVDGHT--VSIFSQSFYTSRCGYRLCARAYLNGDGSGR-GTHLSLYF--VVMRGEFDSLLQWPFRQR---VTLMLLDQS----GK--- E_caballus_ENSECAP00000005414 -G---------------KLIWKVTDYKMKKREALEGHT--VSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYF--VVMRGEFDSLLQWPFRQR---VTLMLLDQS----GK--- C_intestinalis_ENSCINP00000027890 -G---------------VVIWKIRDFSRRKREAVSGRT--LSLYSQPFYTSRYGYKMCARVYLNGDGMGK-GTHMSLFF--VVMKGEYDALLPWPFRQK---VTLMLLDQG----MD--- C_familiaris_ENSCAFP00000017853 -G---------------KLIWKVTDYKMKKREALDGHT--VSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYF--VVMRGEFDSLLQWPFRQR---VTLMLLDQS----GK--- C_intestinalis_ENSCINP00000001022 -G---------------VVIWKIRDFSRRKREAVSGRT--LSLYSQPFYTSRYGYKMCARVYLNGDGMGK-GTHMSLFF--VVMKGEYDALLPWPFRQK---VTLMLLDQG----MD--- H_sapiens_ENSP00000336825 -G---------------KLIWKVTDYKMKKREAVDGHT--VSIFSQSFYTSRCGYRLCARAYLNGDGSGR-GSHLSLYF--VVMRGEFDSLLQWPFRQR---VTLMLLDQS----GK--- O_cuniculus_ENSOCUP00000003184 -G---------------VLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF--VIMRGEYDALLPWPFKQK---VTLMLMDQG----SS--- R_norvegicus_ENSRNOP00000058607 -G---------------VFIWKISDFARKRQEAIAGRT--PAIFSPGAVCVLRMLLMLLNVYLQGRGTGR-QTHLSQLS--VCARAYWAVVLQWLLTEQ---VTLMLLDHN----NR--- M_musculus_ENSMUSP00000082710 -G---------------KLIWKVTDYRVKKREAVEGHT--VSVFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYF--VVMRGEFDSLLQWPFRQR---VTLMLLDQS----GK--- T_guttata_ENSTGUP00000003276 -G---------------KLIWKITDYQKKKREAVEGRV--LSIASQPFYTSRCGYRLCARAYLNGDGSGK-GTHISLYF--VVMRGEFDSLLLWPFKQK---VTLMLLDQS----GK--- G_gallus_ENSGALP00000016021 -G---------------KLIWKITDYKMKKKEAVEGRV--LSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHVSLYF--VVMRGEFDSLLPWPFKQK---VTLMLLDQT----GK--- C_intestinalis_ENSCINP00000005981 -G---------------VALWKINNFQPRKREAESGRA--LSIYSQPFYTSRYGYKMCARVYLNGDGMGK-GTHVSLFF--VLMKGEYDNLLPWPFRQK---VTLMLLDQG----LE--- C_intestinalis_ENSCINP00000025605 -G---------------VALWKINNFQRRKREAESGRA--LSIYSQPFYTSRYGYKMCARVYLNGDGMGK-GTHVSLFF--VLMKGEYDNLLPWPFRQK---VTLMLLDQG----LE--- A_carolinensis_ENSACAP00000017068 -G---------------CLLWKIPEVGLRSREARTGNR--PACYSPAFYTSRYGYKVCLKVFLNGEGTGT-GTHLSLFL--VLMKGEYDFQLKWPFRHK---VTFTLLDQD----NK--- O_anatinus_ENSOANP00000013484 -G---------------KLIWKVTDYKMKKREAMEGRS--VSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYF--VVMKGEFDSLLQWPFKQK---VTMMLLDQS----GK--- A_carolinensis_ENSACAP00000016112 -G---------------KLIWKIVDYKTKKKEAVEGSC--LSIFSQPFYTSRCGYRLSTRAYLNGDGSGK-GTHVSLYF--VVMRGEFDSLLPWPFRQK---VTLMLLDQS----GK--- M_domestica_ENSMODP00000003305 -G---------------KLIWKVTDYKMKKKEATEGRT--VSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYF--VVMKGEFDSLLQWPFKQR---VTMMLLDQS----GK--- O_cuniculus_ENSOCUP00000007884 -G---------------KLIWKVTDYKMKKKEAVDGHT--VSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYF--VVMRGEFDSLLQWPFRQR---VTLMLLDQS----GK--- A_carolinensis_ENSACAP00000010321 -G---------------SFLWRITDVHRKCYEAVCGKM--RSFQSPAFYTSRYGHKLCMRIYLNGDGRSK-GSHASLFL--VLLRGEYDALLQWPFAHE---V----------------- X_tropicalis_ENSXETP00000031605 -G---------------KLIWKITDYERKKREAMEGRA--VSIFSQHFYTSWCGYRLCARAYLNGDGSGK-GSFLSLYF--VVMKGEFDSILLWPFKQK---VTLMLLDQS----GK--- G_gorilla_ENSGGOP00000006994 -G---------------VFIWKISDFARKRQEAVAGRT--PAIFSPXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXX--XXXXXXXXXXXXXXXXXX---VTLMLLDQN----NR--- O_latipes_ENSORLP00000001368 -G---------------RLIWKIKDFQKRREAEATGQH--PCLSSVPFHTGRCGYKMAMKAYLNGDGEGR-GTHLSLYV--VLMPGDFDALLPWPFKQT---VSLSVLDQS----GA--- G_aculeatus_ENSGACP00000025883 -G---------------RLIWKIDDFTNRREAEVRGRP--PCLSSVPFHAGTCGYKLASRVYLNGDGEGR-GTHLSLYV--VLMPGDFDALLPWPFRQT---VSLSLLDQS----GA--- D_rerio_ENSDARP00000014326 -G---------------KLIWKVRDYWHRKESG-------AALSSSPFYTSRSGYKLSVRAYLGGDGSGR-GSHMSLYI--TIMRGDFDSFLPWPFRQN---ITLTLLDQS----GT--- C_intestinalis_ENSCINP00000027041 -G---------------SLIWKIRDFSRRKREAVSGRA--LSLYSQPFYTSRYGYKMCARVYLNGDGMGK-GTHMSLFF--VVMKGEYDALLTWPFRQK---VSV--------------- P_troglodytes_ENSPTRP00000015252 -G---------------VLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI--RVLPGAFDNLLEWPFARR---VTFSLLDQSDPGLAK--- P_pygmaeus_ENSPPYP00000009119 -G---------------VLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI--RVLPGAFDNLLEWPFARR---VTFSLLDQSDPGLAK--- M_mulatta_ENSMMUP00000028200 -G---------------VLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI--RVLPGAFDNLLEWPFARR---VTFSLLDQSDPGLAK--- B_taurus_ENSBTAP00000016271 -G---------------VLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI--RVLPGAFDNLLEWPFARR---VTFSLLDQSDPGLAK--- H_sapiens_ENSP00000262395 -G---------------VLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI--RVLPGAFDNLLEWPFARR---VTFSLLDQSDPGLAK--- T_nigroviridis_ENSTNIP00000019321 -G---------------ILIWKLNDYSRKLQEAKIRSN--HEFFSPPFYTHRYGYKLQVSAFLNGNGSGE-GSHLSVYI--RVLPGEYDNLLEWPFSYK---VTFSLLDQSDPSLSK--- G_gorilla_ENSGGOP00000016344 -G---------------VLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI--RVLPGAFDNLLEWPFARR---VTFSLLDQSDPGLAK--- E_caballus_ENSECAP00000009502 -G---------------VLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI--RVLPGAFDNLLEWPFARR---VTFSLLDQSDPGLAK--- D_rerio_ENSDARP00000013849 -G---------------VLIWKLTDYSRKLQEAKLRNN--HEFFSPPFYTHRYGYKLQVSAFLNGNGSGE-GSHLSIYI--RVLPGEYDNLLEWPFSYK---VTFSILDQSDPSLSK--- B_taurus_ENSBTAP00000050075 -G---------------VLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI--RVLPGAFDNLLEWPFARR---VTFSLLDQSDPGLAK--- M_musculus_ENSMUSP00000017530 -G---------------VLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSIYI--RVLPGAFDNLLEWPFARR---VTFSLLDQSDPGLAK--- G_aculeatus_ENSGACP00000014759 -G---------------VLIWKLSDYSRKLQEAKLRSN--HEFFSPPFYTHRYGYKLQVSAFLNGNGSGE-GSHLSVYI--RVLPGEYDSLLEWPFSYK---VTFSILDQSDPSLSK--- R_norvegicus_ENSRNOP00000018468 -G---------------VLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSIYI--RVLPGAFDNLLEWPFARR---VTFSLLDQSDPGLAK--- T_rubripes_ENSTRUP00000012878 -G---------------ILIWKLNDYSRKLQEAKIRSN--HEFFSPPFYTHRYGYKLQVSAFLNGNGSGE-GSHLSVYI--RVLPGEYDNLLEWPFSYK---VTFSLLDQSDPSLSK--- O_latipes_ENSORLP00000005579 -G---------------VLIWKLNDYSRKLQEAKLRSN--HEFFSPPFYTHRYGYKLQVSAFLNGNGSGE-GSHLSVYI--RVLPGEYDNLLEWPFSYK---VTFSILDQSDPSLSK--- M_domestica_ENSMODP00000024090 -G---------------VLIWKIGGYGRRLQEAKARAN--HECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI--RVLPGAFDNLLEWPFARR---VTFSLLDQSDPAVAK--- X_tropicalis_ENSXETP00000056667 -G---------------VLIWKISDYSRKVQEAKVRGN--FESFSPPFYTHKYGYKLQVSAFLNGNGSGE-GSYLSVYI--RVLPGEYDNLLEWPFSYR---VTFSLLDQSDPSLSK--- A_gambiae_AGAP010017-PA -G---------------TLLWKITDWSVKMQEAKTKDG--LELVSPPFYTSQYGYKLQASMFLNGNGPGE-GTHVSVYI--KVLPGEYDALLKWPFSHS---VTFTLFEQG--TLGSGGG A_aegypti_AAEL006649-PA -G---------------TLLWKITDWSAKMVEAKSKDG--LELVSPPFYTSQYGYKLQASMFLNGNGPGE-GTHVSVYI--KVLPGEYDALLKWPFSHS---VTFTLFEQG--TLGS--- D_rerio_ENSDARP00000056877 -G---------------TLLWKLTDFSQRLQEAKTRTSGCLELFSPAFYSHNYGYRLQVSAFLNGNGSGE-DTHMSVYL--RVLPGEYDGLLEWPFPYR---VSFSLLDQCDPALTK--- D_melanogaster_FBpp0111838 -G---------------TLLWKITDWSAKMAEARGKDG--LELVSPPFYTSQYGYKLQASMFLNGNGPGE-NTHVSVYI--KVLPGEYDALLKWPFSHS---ITFTLFEQG--AQSG--- O_anatinus_ENSOANP00000019424 -G---------------VLVWRIGGYGRRLQEARGRPN--HECLSRPFYTHKYGYRLQVSAFLNGNGSGE-GTHLSLYI--RVLPGDYDNLLEWPFALR---VTFSLLDQSDPSLSK--- M_domestica_ENSMODP00000024756 -G---------------IYIWKINNFGMHLKSQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPSAQRCANYISLFV--HTMQGEYDSHLPWPFQGT---IRLTILDQSEAP-VR--- C_intestinalis_ENSCINP00000003738 -S---------------QLLWKISEWSSKKIEAEAGKR--TVLQSPLFYSARFQYKLAVLLLPNGDGKAK-GTHLSIYV--RLCKGEYDALLSWPYRLP---IEISLIDQSQDPRAR--- M_mulatta_ENSMMUP00000021907 -G---------------IYIWKIGNFGMHLKCQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFV--HTMQGEYDSHLPWPFQGT---IRLTILDQSEAP-VR--- D_rerio_ENSDARP00000036715 -G---------------IYVWRVENFSHHLRNQEAGQP--IVLHSPPFYTGRPGYKLCLRLHLQTPSAPRCSNFISLFV--HTMQGEFDSQLSWPLQGT---IRLAVLDQV----EG--- M_musculus_ENSMUSP00000004949 -G---------------IYIWKIGNFGMHLKSQEEERP--VVIHSPGFYTGRPGYKLCMRLHLQLPTAQRCANYISLFV--HTMQGEYDSHLPWPFQGT---IRLTILDQSEAL-IR--- H_sapiens_ENSP00000316840 -G---------------IYIWKIGNFGMHLKCQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFV--HTMQGEYDSHLPWPFQGT---IRLTILDQSEAP-VR--- R_norvegicus_ENSRNOP00000006148 -G---------------IYIWKIGNFGMHLKSQEEERP--VVIHSPGFYTGRPGYKLCMRLHLQLPTAQRCANYISLFV--HTMQGEYDSHLPWPFQGT---IRLTILDQSEAV-IR--- P_pygmaeus_ENSPPYP00000003845 -G---------------IYIWKIGNFGMHLKCQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFV--HTMQGEYDSHLPWPFQGT---IRLTILDQSEAP-VR--- P_troglodytes_ENSPTRP00000006096 -G---------------IYIWKIGNFGMHLKCQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFV--HTMQGEYDSHLPWPFQGT---IRLTILDQSEAP-VR--- O_anatinus_ENSOANP00000018657 -G---------------IYIWKIGNFGMHLKSQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPNAQRCANYISLFV--HTMQGEYDSHLPWPFQGT---IRLTILDQSEAP-VR--- O_cuniculus_ENSOCUP00000010330 -G---------------IYIWKIGNFGMHLKSQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFV--HTMQGEYDSHLPWPFQGT---IRLTILDQSEAP-IR--- G_gorilla_ENSGGOP00000005734 -G---------------IYIWKIGNFGMHLKCQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFV--HTMQGEYDSHLPWPFQGT---IRLTILDQSEAP-VR--- A_carolinensis_ENSACAP00000005007 -G---------------IFIWKIEHFSVYLKALEEERP--VVIHSPGFYTGKPGYKLCMRLHIQLPNVQRCANYISLFV--HIMQGEYDNYLPWPFQGT---IRLSVLDQSEGS-PR--- T_guttata_ENSTGUP00000010462 -G---------------IYIWKIENFSGLQRAQEEERP--VVLHSPGFYTGKPGYKLCLRLHIQLPNAQRCANFISLFV--HTMQGEYDSHLPWPFQGT---IRLSILDQSEGP-ER--- C_familiaris_ENSCAFP00000010159 -G---------------IYIWKIGNFGMHLKSQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFV--HTMQGEYDSHLPWPFQGT---IRLAILDQSEAP-VR--- X_tropicalis_ENSXETP00000016445 -G---------------IFIWRINNFNSLLKNQEEERP--VVIHSQGFYTGKPGYKLCLRLHLQLPSAQRCANYISLFV--HTMQGEYDSLLPWPLQGT---IRLSILDQSEGV-AM--- B_taurus_ENSBTAP00000021630 -G---------------IYIWKIGNFGMHLKSQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPSAQRCANYISLFV--HTMQGEYDSHLPWPFQGT---IRLTILDQSEAA-VR--- E_caballus_ENSECAP00000018618 -G---------------IYIWKIGNFGMHLKSQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFV--HTMQGEYDSHLPWPFQGT---IRLTILDQSEAP-IR--- G_gallus_ENSGALP00000012873 -G---------------IYIWKIENFSGLQKAQEEERP--VVMHSPGFYTGKPGYKLCLRLHIQLPSAQRCANFISLFV--HTMQGEYDSHLPWPFQGT---IRLSILDQSEGP-ER--- T_nigroviridis_ENSTNIP00000012472 -G---------------IYIWRLKDFSVLLRNQEAGLP--VVEHSPGFYTGRPGYKLCLRLHLQSPVAQRCSNFISLFV--HTMQGAYDGLLTWPFQGT---IRLAILDQ--GP-EG--- T_rubripes_ENSTRUP00000041697 -G---------------IFIWRLKDFSVLLRNQEAGLP--VVEHSPAFYTGRPGYKLCLRLHLQSPNAQRCSNFISLFV--HTMQGAFDGRLTWPFQGT---IRLAILDQ--GP-EG--- O_latipes_ENSORLP00000001290 -G---------------IFIWRLKAFSTHLRSQEAGIP--VVEHSPGFYTGRPGYKLCLRLHLQTPTAPRCSNFISLFV--HTMQGVFDSQLTWPFQGT---IRLAILDQ--GP-EG--- M_mulatta_ENSMMUP00000022296 -G---------------VLIWKTGSCGQWLQEAKAKPN--LECFSPAFYTQKCGYKLQVSAFLNDKGSGE-GTRLSLYI--DLLPGAFDNLLEWSFAPC---VTFCLLDQSDPGLAK--- M_mulatta_ENSMMUP00000021905 -G---------------IYIWKIGS---HLKCQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLLTAQRCANYISLFV--HTMQGEYDSHLPWPF-GT---ICLTILDQSQAP-VR--- G_aculeatus_ENSGACP00000022648 -G---------------IFIWRLRGFSAHLRNQEAGQP--VVEHSPGFYTGRPGYKLCLRLHLQTPNAPRCSNFISLFV--HTMQGAFDGQLSWPFQGT---IRLAILDQ--GP-EA--- C_elegans_F45G2.6 -P---------------QLIWKIDKLQQRTNEAKSGAD--TTIFSVPFMSHRFGYKMMACACLFGDGSSA-GKSISLYV--LLLKGEFDPTLEWPFHRA---IKISLLDQNPRPEDR--V A_gambiae_AGAP000388-PA -G---------------HVMWRIDNFANRLQQSKELE---TMMKGPIFTNYPYGYMLQLEVSLYGIGTWR-GRNLIAGL--TILPGPYDELLEWPCRLS---ATICVRDQA----AN--- D_melanogaster_FBpp0074051 -G---------------HLIWRIKDYSKKLEESKQYD---TILHSAMFSNKAFGYALRLDIYLNGKGTWK-GRNMIACL--NVLSGEYDPLLAWPCRLQ---AEIIIRDQC----TN--- A_gambiae_AGAP003004-PA -G---------------VLLWKLDDFSNKIESMVANSN--CMFYSSEAYTSPHGYKFCARINVS----PRTKDSIGLHV--HLMQSENDYHLEWPFKGR---IKITLLNVR----SP--- A_aegypti_AAEL011363-PA -G---------------HLIWRIDQFEKRFEESQQSE---FMLKSPLFSNRQFGYTLRMEASLNGIGTWR-GRNMIVGL--VVVNGFYDNLLEWPCVLS---GTITLRDQPE---VR--- D_melanogaster_FBpp0071136 -G---------------TIVWRIEQLGALVARLRANAN--NQVYSHECYTSPHGYKFCARLNIQ----PRKPHVLSLHV--HLMQSENDYHLDWPFKGR---IKLCMVHPA----DA--- A_aegypti_AAEL015342-PA -G---------------HLIWRIDQFEKRFEESQQSE---FMLKSPLFSNRPFGYTLRMEASLNGIGTWR-GRNMIVGL--VVVNGFYDNLLEWPCVLS---GTITLRDQPQ---DR--- A_carolinensis_ENSACAP00000017602 -GGLSIDDVNLSETRCPHHVWHIRNFTELLSSSPLGEA--GSLYSPPFYSPE-GYAFQIALYVNGSSS---PFNLAIYV--HLISGENDNQLQWPCAWKQ--ITMVLLDQHPDIMQR--- 850 860 870 880 890 900 910 920 930 940 950 960 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000362994 --EHAIDAFRPDL---SSA---SFQRP------------QSE-T--NVAS-GCPLFFPLSKLQSPKH-AYVKDDTMFL---KCIVE-TST------------------------------ P_troglodytes_ENSPTRP00000036416 --EHAIDAFRPDL---SSA---SFQRP------------QSE-T--NVAS-GCPLFLPLSKLQSPKH-AYVKDDTMFL---KCIVE-TST------------------------------ P_pygmaeus_ENSPPYP00000021917 --EHAIDAFRPDL---SSA---SFQRP------------QSE-T--NVAS-GCPLFFPLSKLQSPKH-AYVKDDTMFL---KCIVE-TST------------------------------ M_mulatta_ENSMMUP00000026496 --EHAIDAFRPDL---SSA---SFQRP------------QSE-T--NVAS-GCPLFFPLNKLQSPKH-AYVKDDTMFL---KCIVE-TST------------------------------ E_caballus_ENSECAP00000009372 --EHAIDAFRPDL---NSA---SFQRP------------QSE-T--NVAS-GCPLFFPLSRLQSPKH-AYVKDDTMFL---KCIVE-TSA------------------------------ B_taurus_ENSBTAP00000041215 --EHAIDAFRPDL---NSA---SFQRP------------QSE-T--NVAS-GCPLFFPLNKLQSPKH-AYVKDDTMFV---KCVVD-TNT------------------------------ M_musculus_ENSMUSP00000028234 --EHAIDAFRPDL---SSA---SFQRP------------QSE-T--NVAS-GCPLFFPLSKLQSPKH-AYVKDDTMFL---KCIVD-TSA------------------------------ O_cuniculus_ENSOCUP00000004916 --EHAIDAFRPDL---SSA---SFQRP------------QSE-T--NVAS-GCPLFFPLNKLQSPKH-AYVKDDTMFL---KCIVE-TSA------------------------------ C_familiaris_ENSCAFP00000031262 --EHAIDAFRPDL---SSA---SFQRP------------QSE-T--NVAS-GCPLFFPLSRLQSPKH-AYVKDDTMFL---KCIVE-TNA------------------------------ G_gorilla_ENSGGOP00000002249 --EHAIDAFRPDL---SSA---SFQRP------------QSE-T--NVAS-GCPLFFPLSKLQSPKH-AYVKDDTMFL---KCIVE-TST------------------------------ M_domestica_ENSMODP00000024498 --EHVTDSFHPDL---TSG---SFQKP------------QGE-S--NIAS-GRPMFFPLNKLQSSKH-AYVKDDTLFL---KCVIE-TNS------------------------------ O_anatinus_ENSOANP00000001757 --EHVIDAFRPDL---NSA---SFQKP------------QGE-M--NVAS-GCPMFFPLNKLQSPKH-AYVKDDTLFL---KCIIE-TNS------------------------------ T_guttata_ENSTGUP00000006737 --EHIIDAFRPDL---TSA---SFQRP------------VND-M--NVAS-GCPMFLPLAKLQSPKH-GYVREDTLFL---KCIIE---------------------------------- G_gallus_ENSGALP00000002401 --EHIIDAFRPDL---ASA---SFQRP------------VND-M--NVAS-GCPTFLPLTKLQSPKH-AYVKEDTLFL---KCIID-LTAV----------------------------- D_rerio_ENSDARP00000091948 --EHVIDAFRPDL---SSM---SFHQP------------VSD-M--NVAS-GCPLFFPLKKLRSPKH-AYCKDDTIYI---KCVVD-TSS------------------------------ T_nigroviridis_ENSTNIP00000011878 --EHIIDAFRPDV---TSS---SFQRP------------ISE-M--NIAS-GCPLFCPLAKLAG-KS-PYLKDDTIFI---KAIVD-LTGL----------------------------- T_rubripes_ENSTRUP00000015632 --EHIIDAFRPDV---TSS---SFQRP------------VSE-M--NIAS-GCPLFCPLSKLDG-KN-SYIRDDTIFI---KAIVD-LTGL----------------------------- D_rerio_ENSDARP00000069217 --EHIIDAFRPDV---SST---SFQRP------------ISE-M--NIAS-GCPLFCPLAKLAG-KS-SYLRDDTIFI---KAIVD-LTGL----------------------------- T_rubripes_ENSTRUP00000047803 --EHIIDAFRPDV---TSS---SFQRP------------ISE-M--NIAS-GCPLFCPLAKLAG-KS-PYLKDDTIFI---KAIVD-LTGL----------------------------- O_latipes_ENSORLP00000020860 --EHIIDAFRPDI---SSS---SFQRP------------VSD-M--NIAS-GCPLFCPLSKLDS-KN-SYIRDETIFI---KAIVD-LSGL----------------------------- T_rubripes_ENSTRUP00000011363 --EHIIDAFRPDI---SSS---SFQRP------------VSD-M--NIAS-GCPLFCPLPKLDC-KN-SYIRDDTIFI---KVIVD-LTGL----------------------------- O_latipes_ENSORLP00000003220 --EHIIDAFRPDV---TSS---SFQRP------------VSE-M--NIAS-GCPLFCPLSKLDA-KN-SYIRDDTIFI---KAIVD-LTGL----------------------------- G_gallus_ENSGALP00000014649 --EHIIDAFRPDV---TSS---SFQRP------------VTE-M--NIAS-GCPLFCPVSVMEA-KN-SYVRDDAIFI---KAIVD-LSGL----------------------------- C_familiaris_ENSCAFP00000028895 --EHVIDAFRPDV---TSS---SFQRP------------VSD-M--NIAS-GCPLFCPVSKMEA-KN-SYVRDDAIFI---KAIVD-LTGL----------------------------- M_domestica_ENSMODP00000021625 --EHVIDAFRPDV---TSS---SFQRP------------VSD-M--NIAS-GCPLFCPVSKMES-KN-SYVRDDAIFI---KAIVD-LTGL----------------------------- D_rerio_ENSDARP00000043465 --EHIIDAFRPDI---SSS---SFQRP------------VSD-M--NIAS-GCPLFCPLSKLDS-KN-SYIRDDTIFI---KAIVD-LTGL----------------------------- O_latipes_ENSORLP00000008989 -EEHIIDAFRPDI---TST---SFQRP------------VSE-M--NIAS-GCPLFCPLAKLAG-KS-PYLRDDTIFI---KAIVD-LSGL----------------------------- T_nigroviridis_ENSTNIP00000016461 --EHIIDAFRPDV---TSS---SFQRP------------VSE-M--NIAS-GCPLFCPLSKLDG-KN-SYIRDDTIFI---KAIVD-LTGL----------------------------- E_caballus_ENSECAP00000011150 --EHVIDAFRPDV---TSS---SFQRP------------VSD-M--NIAS-GCPLFCPVSKMEA-KN-SYVRDDAIFI---KAIVD-LTGL----------------------------- T_guttata_ENSTGUP00000002510 --EHIIDAFRPDV---TSS---SFQRP------------VTE-M--NIAS-GCPLFCPVSVMEA-KN-SYVRDDAIFI---KAIVD-LTGL----------------------------- G_aculeatus_ENSGACP00000022084 --EHIIDAFRPDV---TST---SFQRP------------ISE-M--NIAS-GCPLFCPLAKLAG-KS-PYLRDDTIFI---KAIVD-LTGL----------------------------- P_pygmaeus_ENSPPYP00000022191 --EHVIDAFRPDV---TSS---SFQRP------------VND-M--NIAS-GCPLFCPVSKMEA-KN-SYVRDDAIFI---KAIVD-LTGL----------------------------- M_mulatta_ENSMMUP00000015132 --EHVIDAFRPDV---TSS---SFQRP------------VND-M--NIAS-GCPLFCPVSKMEA-KN-SYVRDDAIFI---KAIVD-LTGL----------------------------- P_troglodytes_ENSPTRP00000036949 --EHVIDAFRPDV---TSS---SFQRP------------VND-M--NIAS-GCPLFCPVSKMEA-KN-SYVRDDAIFI---KAIVD-LTGL----------------------------- M_musculus_ENSMUSP00000109872 --EHVIDAFRPDV---TSS---SFQRP------------VSD-M--NIAS-GCPLFCPVSKMEA-KN-SYVRDDAIFI---KAIVD-LTGL----------------------------- H_sapiens_ENSP00000247668 --EHVIDAFRPDV---TSS---SFQRP------------VND-M--NIAS-GCPLFCPVSKMEA-KN-SYVRDDAIFI---KAIVD-LTGL----------------------------- G_aculeatus_ENSGACP00000006974 --EHIIDAFRPDV---SSS---SFQRP------------VSD-M--NIAS-GCPLFCPLPKLDS-KN-SYIRDDTIFI---KAIVD-LTGL----------------------------- T_nigroviridis_ENSTNIP00000013509 --EHIIDAFRPDV---SSS---SFQRP------------VSD-M--NIAS-GCPLFCPLSKLDC-KN-SYIRDDTIFI---KVIVD-LSGL----------------------------- B_taurus_ENSBTAP00000013869 --EHVIDAFRPDV---TSS---SFQRP------------VGD-M--NIAS-GCPLFCPVSKMEA-KN-SYVRDDAIFI---KAIVD-LTGL----------------------------- X_tropicalis_ENSXETP00000042386 --DSVFDAFRPDV---TSA---SFQRP------------IND-M--NVAS-GCPLFCPIAKLNSPKH-AYIRENTLYI---RCIID-TNS------------------------------ X_tropicalis_ENSXETP00000008559 --EHVIDAFRPDV---SSS---SFQRP------------ISE-M--NIAS-GCPLFCQVSKLEG-KN-SYVRDDTIFV---KVIVD-LTGL----------------------------- G_aculeatus_ENSGACP00000020860 --EHIIDAFRPDV---TSS---SFQRP------------LER---------PCSL-------------CF-------------------------------------------------- G_gorilla_ENSGGOP00000004192 -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- H_sapiens_ENSP00000376500 -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- P_troglodytes_ENSPTRP00000011503 -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- P_pygmaeus_ENSPPYP00000007003 -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- G_gallus_ENSGALP00000036699 -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- R_norvegicus_ENSRNOP00000010906 -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- T_guttata_ENSTGUP00000013203 -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- O_anatinus_ENSOANP00000023053 -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- B_taurus_ENSBTAP00000017918 -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- C_familiaris_ENSCAFP00000026713 -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- E_caballus_ENSECAP00000011833 -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- M_musculus_ENSMUSP00000021706 -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- X_tropicalis_ENSXETP00000027864 -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- M_domestica_ENSMODP00000016701 -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- A_carolinensis_ENSACAP00000000193 -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- T_rubripes_ENSTRUP00000013348 -KKHLGDAFKPDP---NSS---SFRRP------------VVE-M--NIAS-GCPLFVSQSVLETG---SYIKDDTIFI---KVTVD-TSDLPEP-------------------------- D_rerio_ENSDARP00000038596 -RKHLGDAFKPDP---SSS---SFRRP------------TGE-M--NIAS-GCPLFVAQTVLENG---TYIKDDTIFI---KVTVD-TSDLPDP-------------------------- T_nigroviridis_ENSTNIP00000005138 -KKHLGDAFKPDP---NSS---SFRRP------------VVE-M--NIAS-GCPLFVSQSVLETG---SYIKDDTIFI---KVTVD-TSDLPEP-------------------------- G_aculeatus_ENSGACP00000005703 -RKHLGDAFKPDP---NSS---SFRRP------------AAE-M--NIAS-GCPLFVSQSVLETG---TYIKDDTIFI---KVTVD-TSDLPDP-------------------------- C_intestinalis_ENSCINP00000003143 -RRHLSDTFRPDP---TSS---SFKKP------------TSD-M--NIAS-GCPLFVAHNVIEDS---SYVKEDTIFL---RIHVD-TSDLENF-------------------------- B_taurus_ENSBTAP00000015940 -KNHIMETFKADP---NSS---SFKRP------------DGE-M--NIAS-GCPRFVAHSTLENAKN-TYIKDDTLFL---KVAVD-LTDLEDL-------------------------- C_intestinalis_ENSCINP00000001432 -RRHLSDTFRPDP---TSS---SFKKP------------TSD-M--NIAS-GCPLFVAHNVIEDS---SYVKEDTIFL---RIHVD-TSDLENF-------------------------- M_mulatta_ENSMMUP00000015419 -RRHLGDAFKPDP---NSS---SFKKP------------TGE-M--NIAS-GCPVFVAQTVLENG---TYIK------------------------------------------------ M_mulatta_ENSMMUP00000038268 -KN-IMETFKPDP---NSS---SFKRP------------DGE-M--NIAS-GCPRFVAHSVLENAKN-AYIKDDTLFL---KVAVD-LTDLEDL-------------------------- P_pygmaeus_ENSPPYP00000000253 -KN-IMETFKPDP---NSS---SFKRP------------DGE-M--NIAS-GCPRFVAHSVLENAKN-AYLKDDTLFL---KVAVD-LTDLEDL-------------------------- P_troglodytes_ENSPTRP00000003288 -KN-IMETFKPDP---NSS---SFKRP------------DGE-M--NIAS-GCPRFVAHSVLENAKN-AYIKDDTLFL---KVAVD-LTDLEDL-------------------------- E_caballus_ENSECAP00000005414 -KNHIMETFKADP---NSS---SFKRP------------DGE-M--NIAS-GCPRFVAHSTLENAKN-TYIKDDTIFL---KVAVD-LTDLEDL-------------------------- C_intestinalis_ENSCINP00000027890 -RRHLSDTFRPDP---TSS---SFKKP------------TSD-M--NIAS-GCPLFVAHNVIEDS---SYVKEDTIFL---RIHVD-TSDLENF-------------------------- C_familiaris_ENSCAFP00000017853 -KNHIMETFKADP---SSS---SFKRP------------DGE-M--NIAS-GCPRFVAHSTLENAKN-TYIKDDTVFL---KVAVD-LTDLEDL-------------------------- C_intestinalis_ENSCINP00000001022 -RRHLSDTFRPDP---TSS---SFKKP------------TSD-M--NIAS-GCPLFVAHNVIEGS---SYVKEDTIFL---RIHVD-TSDLENF-------------------------- H_sapiens_ENSP00000336825 -KN-IMETFKPDP---NSS---SFKRP------------DGE-M--NIAS-GCPRFVAHSVLENAKN-AYIKDDTLFL---KVAVD-LTDLEDL-------------------------- O_cuniculus_ENSOCUP00000003184 -RRHLGDAFKPDP---NSS---SFRKP------------TGE-M--NIAS-GCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLPDP-------------------------- R_norvegicus_ENSRNOP00000058607 --EHVIDAFRPDV---TSS---SFQRP------------VSD-M--NIAS-GCPLFCPVSKIEA-KN-SYVRDDAIFI---KAIVD-LTGL----------------------------- M_musculus_ENSMUSP00000082710 -KNHIVETFKADP---NSS---SFKRP------------DGE-M--NIAS-GCPRFVSHSTLENSKN-TYIKDDTLFL---KVAVD-LTDLEDL-------------------------- T_guttata_ENSTGUP00000003276 -KNHIVDVFRADP---NSS---SFKRP------------DGE-M--NIAS-GCPRFVPHTVLESTKN-TYIRDDTLFL---KVVVD-LTDLEEL-------------------------- G_gallus_ENSGALP00000016021 -KNHIVEVFRADP---NSS---SFKRP------------DGE-M--NIAS-GCPRFVPHTVLENTKN-TYVRDDTLFL---KVVVD-LTDLEEL-------------------------- C_intestinalis_ENSCINP00000005981 -RRHLSDMFRPDP---TSS---SFTKP------------TSD-M--NIAS-GCPLFVAHNLIEGS---SYVKDDVIFI---RIHVD-TTDLETF-------------------------- C_intestinalis_ENSCINP00000025605 -RRHLSDMFRPDP---TSS---SFTKP------------TSD-M--NIAS-GCPLFVAHNLIEGS---SYVKDDVIFI---RIHVD-TTDLETF-------------------------- A_carolinensis_ENSACAP00000017068 --QHISTSFRPLE---SSS---SFQRP------------VNE-T--NVAS-GLPEFCPLNVLHSPRT-SYICNDTLAI---QAVID-M-------------------------------- O_anatinus_ENSOANP00000013484 -KNHIVEIFKADP---NSS---SFKRP------------EGE-M--NIAS-GCPCFVDHSKLENVKN-TFIKEDTLFM---KVVVD-LTDLEEL-------------------------- A_carolinensis_ENSACAP00000016112 -KNHIVETFKADP---NSS---SFKRP------------EGE-M--NVAS-GCPRFVPHTLLENAKS-TYIKDDTIFL---KVVVD-LTDLEEL-------------------------- M_domestica_ENSMODP00000003305 -KNHITEIFKADP---NSS---SFKRP------------DGE-M--NIAS-GCPRFVAHSTLESTKN-TYIKEDTLFM---KVVVD-LSDLEDL-------------------------- O_cuniculus_ENSOCUP00000007884 -RNHIMETFKADP---NSS---SFKRP------------DGE-M--NIAS-GCPRFVAHSTLENAKN-TYIKEDTLFL---KVAVD-LTDLEDL-------------------------- A_carolinensis_ENSACAP00000010321 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000031605 -KNHITDVFRADP---NSS---SFKRP------------DSE-M--NIAS-GCPRFASHAQLENPKNGCYIK------------------------------------------------ G_gorilla_ENSGGOP00000006994 --EHVIDAFRPXV---TSS---SFQRP------------VND-M--NIAS-GCPLFCPVSKMEA-KN-SYVRDDAIFI---KAIVD-LTGL----------------------------- O_latipes_ENSORLP00000001368 -RNHQSFNFRPDP---TNT---CFHQP------------AAE-SASNVAV-GFPCFISLDALEAPGNAVYVKDDTLFV---KVKVD-TTGLE---------------------------- G_aculeatus_ENSGACP00000025883 -ANHRSLSFRPDP---SSK---SFGRP------------AAE-SAGNVAV-GFSCFLPLGELEPRHNAEYVKDDALFV---KVKVD-TAGLDPL-------------------------- D_rerio_ENSDARP00000014326 -RNHMSHTFIPDV---NSD---SFHRP------------TSD-A--NVAT-GFTRFISHCDLENPRNAVFVRDETLFI---KVKV----------------------------------- C_intestinalis_ENSCINP00000027041 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000015252 -PQHVTETFHPDP---NWK---NFQKP-----GTWRGS-LDE-S--SLGF-GYPKFISHQDIRKR---NYVRDDAVFI---RAAVELPRKILS--------------------------- P_pygmaeus_ENSPPYP00000009119 -PQHVTETFHPDP---NWK---NFQKP-----GTWRGS-LDE-S--SLGF-GYPKFISHQDIRKR---NYVRDDAVFI---RAAVELPRKILS--------------------------- M_mulatta_ENSMMUP00000028200 -PQHVTETFHPDP---NWK---NFQKP-----GTWRGS-LDE-S--SLGF-GYPKFISHQDIRKR---NYVRDDAVFI---RAAVELPRKILS--------------------------- B_taurus_ENSBTAP00000016271 -PQHVTETFHPDP---NWK---NFQKP-----GTWRGS-LDE-S--SLGF-GYPKFISHQDIRKR---NYVRDDAVFI---RASVELPRKILS--------------------------- H_sapiens_ENSP00000262395 -PQHVTETFHPDP---NWK---NFQKP-----GTWRGS-LDE-S--SLGF-GYPKFISHQDIRKR---NYVRDDAVFI---RAAVELPRKILS--------------------------- T_nigroviridis_ENSTNIP00000019321 -PQHITETFNPDP---NWK---NFQKP-----NSTRNS-LDE-S--TLGF-GYPKFISHEEIKKR---NYIRDNCIFI---KASIEIPQKIMA--------------------------- G_gorilla_ENSGGOP00000016344 -PQHVTETFHPDP---NWK---NFQKP-----GTWRGS-LDE-S--SLGF-GYPKFISHQDIRKR---NYVRDDAVFI---RAAVELPRKILS--------------------------- E_caballus_ENSECAP00000009502 -PQHVTETFHPDP---NWK---NFQKP-----GTWRGS-LDE-S--SLGF-GYPKFISHQDIRKR---NYVRDDAVFI---RASVELPRKILS--------------------------- D_rerio_ENSDARP00000013849 -PQHITETFNPDP---NWK---NFQKP-----CSSRNS-LDE-S--TLGF-GYPKFISHEEIKKR---NYIRDNSIFL---KASIEIPQKIMA--------------------------- B_taurus_ENSBTAP00000050075 -PQHVTETFHPDP---NWK---NFQKP-----GTWRGS-LDE-S--SLGF-GYPKFISHQDIRKR---NYVRDDAVFI---RASVELPRKILS--------------------------- M_musculus_ENSMUSP00000017530 -PQHVTETFHPDP---NWK---NFQKP-----GTWRGS-LDE-S--SLGF-GYPKFISHQDIRKR---NYVRDDAVFI---RASVELPRKILS--------------------------- G_aculeatus_ENSGACP00000014759 -PQHITETFNPDP---NWK---NFQKP-----SSSRNS-LDE-S--TLGF-GYPKFISHDEIKKR---NYIRDNCVFI---KASIEIPQKIMT--------------------------- R_norvegicus_ENSRNOP00000018468 -PQHVTETFHPDP---NWK---NFQKP-----GTWRGS-LDE-S--SLGF-GYPKFISHQDIRKR---NYVRDDAVFI---RASVELPRKILS--------------------------- T_rubripes_ENSTRUP00000012878 -PQHITETFNPDP---NWK---NFQKP-----SSTRNS-LDE-S--TLGF-GYPKFISHEEIKKR---NYVRDNCIFI---KASIEIPQKIMA--------------------------- O_latipes_ENSORLP00000005579 -PQHITETFNPDP---NWK---NFQKP-----CSTRNS-LDE-S--TLGF-GYPKFISHEEIKKR---NYIRDNCIFI---KASIEIPQKIMG--------------------------- M_domestica_ENSMODP00000024090 -PQHVTETFHPDP---HWK---NFQKP-----GTWRGS-MDE-S--ALGF-GYPKFISHQDIRKR---NYVRDDAVFI---RASVELPKKILS--------------------------- X_tropicalis_ENSXETP00000056667 -PQHITETFNPDP---NWK---NFQKP-----TGSRNS-LDE-S--TLGF-GYPKFISHEDIRKR---NYVRDNAIFL---RASVEIPQKIIA--------------------------- A_gambiae_AGAP010017-PA GQGGVAESFVPDP---TWE---NFQRP----------S-TEP-D--ALGF-GFPRFVSHELLNRR---PFVRDDTVFL---RVKVD-PSKIVAV-------------------------- A_aegypti_AAEL006649-PA -QGGVAESFVPDP---SWE---NFQRP----------S-TEP-D--ALGF-GFPRFVSHELLNRR---PFVREDTVFL---RVKVD-PSKIVAV-------------------------- D_rerio_ENSDARP00000056877 -PQHITETFSPDP---TWK---NFQRPRPGALGSIRGGCLDE-S--MLGF-GYPKFISHEEMKKR---NYIRDNAVFI---KASIDVVQKILN--------------------------- D_melanogaster_FBpp0111838 -QGGVAESFVPDP---TWE---NFQRP----------S-NEP-D--QLGF-GFPRFISHELLHSR---PFIKGDTVFL---RVKVD-PSKIVAV-------------------------- O_anatinus_ENSOANP00000019424 -PQHVTETFHPDP---HWK---NFQKP-----GAWRGS-GSSGA--ALGF-GYPKFISHEDIRKR---DYVRDDAVFI---RAAVELPRRILA--------------------------- M_domestica_ENSMODP00000024756 --QNHEEIMDAKP---ELL---AFQRP------------TIP-R--NPKGFGYVTFMHLQALKQR---TFIKDDTLLV---RCEVLTRLDMNSL-------------------------- C_intestinalis_ENSCINP00000003738 --INHTYSLRPNPCKENKP---FLGRP------------TSE-S--NPSF-GSQTFMPLDTLNTR---DYIRDDAIFI---RVSVLHDET------------------------------ M_mulatta_ENSMMUP00000021907 --QNHEEIMDAKP---DLL---AFQRP------------TIP-R--NPKGFGYVTFMHLEALRQR---TFIKDDTLLV---RCEVSTRFDMGSL-------------------------- D_rerio_ENSDARP00000036715 --QHHIEVMETKP---DLQ---AFQRP------------TVM-R--NPKGFGYVTFLHLQALRQR---GFVKEDVLLV---RCEVTPRFD-ASL-------------------------- M_musculus_ENSMUSP00000004949 --QNHEEVMDAKP---ELL---AFQRP------------TIP-R--NPKGFGYVTFMHLEALRQG---TFIKDDTLLV---RCEVSTRFDMGGL-------------------------- H_sapiens_ENSP00000316840 --QNHEEIMDAKP---ELL---AFQRP------------TIP-R--NPKGFGYVTFMHLEALRQR---TFIKDDTLLV---RCEVSTRFDMGSL-------------------------- R_norvegicus_ENSRNOP00000006148 --QNHEEVMDAKP---ELL---AFQRP------------TIP-R--NPKGFGYVTFMHLEALRQG---TFIKDDTLLV---RCEVSTRFDMGGL-------------------------- P_pygmaeus_ENSPPYP00000003845 --QNHEEIMDAKP---ELL---AFQRP------------TIP-R--NPKGFGYVTFMHLEALRQR---TFIKDDTLLV---RCEVSTRFDMGSL-------------------------- P_troglodytes_ENSPTRP00000006096 --QNHEEIMDAKP---ELL---AFQRP------------TIP-R--NPKGFGYVTFMHLEALRQR---TFIKDDTLLV---RCEVSTRFDMGSL-------------------------- O_anatinus_ENSOANP00000018657 --QNHEEIMDTKP---ELL---AFQRP------------TIH-R--NPKGFGYVTFMHLQALRQR---AFIKDDTLLV---RCEVSTRFDMSSP-------------------------- O_cuniculus_ENSOCUP00000010330 --QNHEEIMDAKP---ELL---AFQRP------------TIP-R--NPKGFGYVTFMHLEALRQR---TFIKDDTLLV---RCEVSTRFDMGSL-------------------------- G_gorilla_ENSGGOP00000005734 --QNHEEIMDAKP---ELL---AFQRP------------TIP-R--NPKGFGYVTFMHLEALRQR---TFIKDDTLLV---RCEVSTRFDMGSL-------------------------- A_carolinensis_ENSACAP00000005007 --QNHEEVMDTKP---ELL---AFQRP------------KTR-R--NPKGFGYVTFMQLQTLRQR---TYIKEDTVLV---RCEVLTRLDVMSP-------------------------- T_guttata_ENSTGUP00000010462 --QNHEEVMEAKP---ELL---AFQRP------------TIH-R--NPKGFGYVTFMHLETLKQR---TFIKDDTLLV---RCEVLTRLDLSSV-------------------------- C_familiaris_ENSCAFP00000010159 --QNHEEIMDAKP---ELL---AFQRP------------TIP-R--NPKGFGYVTFMHLEALRQR---TFIKDDTLLV---RCEVSTRFDMGSP-------------------------- X_tropicalis_ENSXETP00000016445 --QDQEEVMDTKP---ELL---AFQRP------------TVA-R--NPKGFGYVTFMHLQALKQR---QYVKNDTLLV---RCSVTTHLDLISP-------------------------- B_taurus_ENSBTAP00000021630 --QNHEEIMDAKP---ELL---AFQRP------------TIP-R--NPKGFGYVTFMHLEALRQR---TFIKDDTLLV---RCEVSTRFDMGSL-------------------------- E_caballus_ENSECAP00000018618 --QNHEEIMDAKP---ELL---AFQRP------------TIP-R--NPKGFGYVTFMHLEALRQR---TFIKDDTLLV---RCEVSTRFDMGSL-------------------------- G_gallus_ENSGALP00000012873 --QNHEEVMEAKP---ELL---AFQRP------------TIH-R--NPKGFGYVTFMHLQTLKQR---TFVKDDTLLV---RCEVLTRLDLNSL-------------------------- T_nigroviridis_ENSTNIP00000012472 --QHHIEVMETKP---DLQ---AFQRP------------TII-R--NPKGFGYVTFLHLHHLKER---AYVKDDALLI---RCEVTPRFD-NML-------------------------- T_rubripes_ENSTRUP00000041697 --QHHVEVMETKP---DLQ---AFQKP------------TII-R--NPKGFGYVTFLHLQQLNQR---AYVKDDILLI---RCEVTPRFD-NMF-------------------------- O_latipes_ENSORLP00000001290 --QHHMEVMETKP---DLQ---AFQKP------------INQ-R--NPKGFGYVTFMHRSLLSQR---AYVKDDTLLI---RCEV----------------------------------- M_mulatta_ENSMMUP00000022296 -PQHITDTFHPGP---NWK---NFQKP-----GTWEGS-LDE-S--SLGF-GYLKFISHQDIQKR---KSYSQNCVFVTWGKCFSILKKKFLS--------------------------- M_mulatta_ENSMMUP00000021905 --QNHEEIMDAKP---ELL---AFQQP------------TYP----NPKGFGYVTFIHLEALRQR---TFIKYDTLLV---RCEVSTCFDMGSL-------------------------- G_aculeatus_ENSGACP00000022648 --QHHVEVMETKP---DLQ---AFQKP------------LIQ-R--NPKGFGYVTFLHLHQLTQR---AFVKDDTLLI---RCEVTPRFD-NVL-------------------------- C_elegans_F45G2.6 NITYVIDPRKLKA---NEK---FLARP------------RGE-R--NAAF-GSQSFCSLAILQ-----NYVKDDKIYV---QIDVDRCETLPVQ-------------------------- A_gambiae_AGAP000388-PA -PAEAVPIYKPIV---AKV---KGQRD------------KNQ----------HYVYVPHDQLYSR---GYVKKDTLFL---EVFVGEEGSDSSEL------------------------- D_melanogaster_FBpp0074051 -VADAEDYVKT-----------IFVRK------------KSD-D--FIQS-NQYFHIPHKVITSR---NYLRNDSMFI---EVRVLK--------------------------------- A_gambiae_AGAP003004-PA -ELSQHDTIMSKP---EIL---AFHRP------------NQD-I--SPRGFGFLEFAKIKDILA----KFADNNTVVI---KIQMNIV-------------------------------- A_aegypti_AAEL011363-PA -TKPRVDYRRSIV-----------ARR------------KHQ-S--NDK--NQNIHIPHQVLRSE---HYIRDDAIFL---EVRIDQ--------------------------------- D_melanogaster_FBpp0071136 -TLSQHDTIMTKP---EIL---AFHKP------------REA-I--STRGFGFLEYANISNIIQL---GFCADDRLLI---KIEINIV-------------------------------- A_aegypti_AAEL015342-PA -AKPRVDYRRSIV-----------ARR------------KHQ-S--NDK--NQNIHIPHQVLRSE---HYIRDDAIFL---EVRIDQ--------------------------------- A_carolinensis_ENSACAP00000017602 --MSNLRSITTDPNKVESSGLYSWDRPDKVGTEATFPNGTKFMR--GPRS-GTNAFLTHERLKSR---GFIKDDSIFI---LATVDDISHLISTQPNFTITNAPTTTTVADPCSAYGCKN 970 980 990 1000 1010 1020 1030 =========+=========+=========+=========+=========+=========+=========+===== H_sapiens_ENSP00000362994 --------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000036416 --------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000021917 --------------------------------------------------------------------------- M_mulatta_ENSMMUP00000026496 --------------------------------------------------------------------------- E_caballus_ENSECAP00000009372 --------------------------------------------------------------------------- B_taurus_ENSBTAP00000041215 --------------------------------------------------------------------------- M_musculus_ENSMUSP00000028234 --------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000004916 --------------------------------------------------------------------------- C_familiaris_ENSCAFP00000031262 --------------------------------------------------------------------------- G_gorilla_ENSGGOP00000002249 --------------------------------------------------------------------------- M_domestica_ENSMODP00000024498 --------------------------------------------------------------------------- O_anatinus_ENSOANP00000001757 --------------------------------------------------------------------------- T_guttata_ENSTGUP00000006737 --------------------------------------------------------------------------- G_gallus_ENSGALP00000002401 --------------------------------------------------------------------------- D_rerio_ENSDARP00000091948 --------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000011878 --------------------------------------------------------------------------- T_rubripes_ENSTRUP00000015632 --------------------------------------------------------------------------- D_rerio_ENSDARP00000069217 --------------------------------------------------------------------------- T_rubripes_ENSTRUP00000047803 --------------------------------------------------------------------------- O_latipes_ENSORLP00000020860 --------------------------------------------------------------------------- T_rubripes_ENSTRUP00000011363 --------------------------------------------------------------------------- O_latipes_ENSORLP00000003220 --------------------------------------------------------------------------- G_gallus_ENSGALP00000014649 --------------------------------------------------------------------------- C_familiaris_ENSCAFP00000028895 --------------------------------------------------------------------------- M_domestica_ENSMODP00000021625 --------------------------------------------------------------------------- D_rerio_ENSDARP00000043465 --------------------------------------------------------------------------- O_latipes_ENSORLP00000008989 --------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000016461 --------------------------------------------------------------------------- E_caballus_ENSECAP00000011150 --------------------------------------------------------------------------- T_guttata_ENSTGUP00000002510 --------------------------------------------------------------------------- G_aculeatus_ENSGACP00000022084 --------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000022191 --------------------------------------------------------------------------- M_mulatta_ENSMMUP00000015132 --------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000036949 --------------------------------------------------------------------------- M_musculus_ENSMUSP00000109872 --------------------------------------------------------------------------- H_sapiens_ENSP00000247668 --------------------------------------------------------------------------- G_aculeatus_ENSGACP00000006974 --------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000013509 --------------------------------------------------------------------------- B_taurus_ENSBTAP00000013869 --------------------------------------------------------------------------- X_tropicalis_ENSXETP00000042386 --------------------------------------------------------------------------- X_tropicalis_ENSXETP00000008559 --------------------------------------------------------------------------- G_aculeatus_ENSGACP00000020860 --------------------------------------------------------------------------- G_gorilla_ENSGGOP00000004192 --------------------------------------------------------------------------- H_sapiens_ENSP00000376500 --------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000011503 --------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000007003 --------------------------------------------------------------------------- G_gallus_ENSGALP00000036699 --------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000010906 --------------------------------------------------------------------------- T_guttata_ENSTGUP00000013203 --------------------------------------------------------------------------- O_anatinus_ENSOANP00000023053 --------------------------------------------------------------------------- B_taurus_ENSBTAP00000017918 --------------------------------------------------------------------------- C_familiaris_ENSCAFP00000026713 --------------------------------------------------------------------------- E_caballus_ENSECAP00000011833 --------------------------------------------------------------------------- M_musculus_ENSMUSP00000021706 --------------------------------------------------------------------------- X_tropicalis_ENSXETP00000027864 --------------------------------------------------------------------------- M_domestica_ENSMODP00000016701 --------------------------------------------------------------------------- A_carolinensis_ENSACAP00000000193 --------------------------------------------------------------------------- T_rubripes_ENSTRUP00000013348 --------------------------------------------------------------------------- D_rerio_ENSDARP00000038596 --------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000005138 --------------------------------------------------------------------------- G_aculeatus_ENSGACP00000005703 --------------------------------------------------------------------------- C_intestinalis_ENSCINP00000003143 --------------------------------------------------------------------------- B_taurus_ENSBTAP00000015940 --------------------------------------------------------------------------- C_intestinalis_ENSCINP00000001432 --------------------------------------------------------------------------- M_mulatta_ENSMMUP00000015419 --------------------------------------------------------------------------- M_mulatta_ENSMMUP00000038268 --------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000000253 --------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000003288 --------------------------------------------------------------------------- E_caballus_ENSECAP00000005414 --------------------------------------------------------------------------- C_intestinalis_ENSCINP00000027890 --------------------------------------------------------------------------- C_familiaris_ENSCAFP00000017853 --------------------------------------------------------------------------- C_intestinalis_ENSCINP00000001022 --------------------------------------------------------------------------- H_sapiens_ENSP00000336825 --------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000003184 --------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000058607 --------------------------------------------------------------------------- M_musculus_ENSMUSP00000082710 --------------------------------------------------------------------------- T_guttata_ENSTGUP00000003276 --------------------------------------------------------------------------- G_gallus_ENSGALP00000016021 --------------------------------------------------------------------------- C_intestinalis_ENSCINP00000005981 --------------------------------------------------------------------------- C_intestinalis_ENSCINP00000025605 --------------------------------------------------------------------------- A_carolinensis_ENSACAP00000017068 --------------------------------------------------------------------------- O_anatinus_ENSOANP00000013484 --------------------------------------------------------------------------- A_carolinensis_ENSACAP00000016112 --------------------------------------------------------------------------- M_domestica_ENSMODP00000003305 --------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000007884 --------------------------------------------------------------------------- A_carolinensis_ENSACAP00000010321 --------------------------------------------------------------------------- X_tropicalis_ENSXETP00000031605 --------------------------------------------------------------------------- G_gorilla_ENSGGOP00000006994 --------------------------------------------------------------------------- O_latipes_ENSORLP00000001368 --------------------------------------------------------------------------- G_aculeatus_ENSGACP00000025883 --------------------------------------------------------------------------- D_rerio_ENSDARP00000014326 --------------------------------------------------------------------------- C_intestinalis_ENSCINP00000027041 --------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000015252 --------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000009119 --------------------------------------------------------------------------- M_mulatta_ENSMMUP00000028200 --------------------------------------------------------------------------- B_taurus_ENSBTAP00000016271 --------------------------------------------------------------------------- H_sapiens_ENSP00000262395 --------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000019321 --------------------------------------------------------------------------- G_gorilla_ENSGGOP00000016344 --------------------------------------------------------------------------- E_caballus_ENSECAP00000009502 --------------------------------------------------------------------------- D_rerio_ENSDARP00000013849 --------------------------------------------------------------------------- B_taurus_ENSBTAP00000050075 --------------------------------------------------------------------------- M_musculus_ENSMUSP00000017530 --------------------------------------------------------------------------- G_aculeatus_ENSGACP00000014759 --------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000018468 --------------------------------------------------------------------------- T_rubripes_ENSTRUP00000012878 --------------------------------------------------------------------------- O_latipes_ENSORLP00000005579 --------------------------------------------------------------------------- M_domestica_ENSMODP00000024090 --------------------------------------------------------------------------- X_tropicalis_ENSXETP00000056667 --------------------------------------------------------------------------- A_gambiae_AGAP010017-PA --------------------------------------------------------------------------- A_aegypti_AAEL006649-PA --------------------------------------------------------------------------- D_rerio_ENSDARP00000056877 --------------------------------------------------------------------------- D_melanogaster_FBpp0111838 --------------------------------------------------------------------------- O_anatinus_ENSOANP00000019424 --------------------------------------------------------------------------- M_domestica_ENSMODP00000024756 ---------------------------------RREG--FQPRSTDAGV-------------------------- C_intestinalis_ENSCINP00000003738 --------------------------------------------------------------------------- M_mulatta_ENSMMUP00000021907 ---------------------------------RREG--FQPRSTDSGV-------------------------- D_rerio_ENSDARP00000036715 ---------------------------------RREG--VQPRGPEPSI-------------------------- M_musculus_ENSMUSP00000004949 ---------------------------------RKEG--FQPRSTDAGV-------------------------- H_sapiens_ENSP00000316840 ---------------------------------RREG--FQPRSTDAGV-------------------------- R_norvegicus_ENSRNOP00000006148 ---------------------------------RKEG--FQPRSTDAGV-------------------------- P_pygmaeus_ENSPPYP00000003845 ---------------------------------RREG--FQPRSTDAGV-------------------------- P_troglodytes_ENSPTRP00000006096 ---------------------------------RREG--FQPRSTDAGV-------------------------- O_anatinus_ENSOANP00000018657 ---------------------------------RREG--FQPRSTDPGV-------------------------- O_cuniculus_ENSOCUP00000010330 ---------------------------------RREG--FQPRSTDAGV-------------------------- G_gorilla_ENSGGOP00000005734 ---------------------------------RREG--FQPRSTDAGV-------------------------- A_carolinensis_ENSACAP00000005007 ---------------------------------RREG--FQPRSTDGTV-------------------------- T_guttata_ENSTGUP00000010462 ---------------------------------RREG--FQPRSTDGAM-------------------------- C_familiaris_ENSCAFP00000010159 ---------------------------------RREG--FQPRSTDSGI-------------------------- X_tropicalis_ENSXETP00000016445 ---------------------------------RREG--FQPRSGDGAL-------------------------- B_taurus_ENSBTAP00000021630 ---------------------------------RREG--FQPRSTDSGI-------------------------- E_caballus_ENSECAP00000018618 ---------------------------------RREG--FQPRSTDTGV-------------------------- G_gallus_ENSGALP00000012873 ---------------------------------RREG--FQARSTDGAA-------------------------- T_nigroviridis_ENSTNIP00000012472 ---------------------------------HRDGVTVQPRGSEASI-------------------------- T_rubripes_ENSTRUP00000041697 ---------------------------------HRDGITVQPRGPEASM-------------------------- O_latipes_ENSORLP00000001290 --------------------------------------------------------------------------- M_mulatta_ENSMMUP00000022296 --------------------------------------------------------------------------- M_mulatta_ENSMMUP00000021905 ---------------------------------RREG--FQPQSTDAGI-------------------------- G_aculeatus_ENSGACP00000022648 ---------------------------------HRDGPTVQPRGPEASVSRD----------------------- C_elegans_F45G2.6 ---------------------------------LKSRDAKERKQMLDAMRAKTPDVRLHQVRPVTSQSSSAELRV A_gambiae_AGAP000388-PA --------------------------------------------------------------------------- D_melanogaster_FBpp0074051 --------------------------------------------------------------------------- A_gambiae_AGAP003004-PA --------------------------------------------------------------------------- A_aegypti_AAEL011363-PA --------------------------------------------------------------------------- D_melanogaster_FBpp0071136 --------------------------------------------------------------------------- A_aegypti_AAEL015342-PA --------------------------------------------------------------------------- A_carolinensis_ENSACAP00000017602 NGTCIIEAGKPVCRCPVGKDWWYVGEKCDEKGTMQDTAVIAVASSLSVFGVMLIITIITTCCIKKKYKEKMQASR