10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000363591 ---------MASGQGPGPPR-----QECGEP--------------------------------------------------------------------------ALPSAS--------- G_gorilla_ENSGGOP00000015828 ---------MASGQGPGPPR-----QECGEP--------------------------------------------------------------------------ALPSAS--------- P_troglodytes_ENSPTRP00000050271 ---------MASGQGPGPPR-----QECGEP--------------------------------------------------------------------------ALPSAS--------- M_mulatta_ENSMMUP00000011943 ---------MASGQGPGPPR-----QECGEP--------------------------------------------------------------------------ALPSASGK------- P_pygmaeus_ENSPPYP00000006150 ---------MASGQGPGPPR-----QECGEP--------------------------------------------------------------------------ALPSAS--------- B_taurus_ENSBTAP00000000549 ---------MASGQGPGPPG-----QDCDEP--------------------------------------------------------------------------DPSSTS--------- E_caballus_ENSECAP00000021385 ---------MASGQGPGPPG-----KECGEP--------------------------------------------------------------------------APSSTS--------- C_familiaris_ENSCAFP00000001449 ---------MASGQGPGPPR-----RECGEA--------------------------------------------------------------------------APSSTS--------- M_musculus_ENSMUSP00000077757 ---------MASGQGPGPPK-----VGCDES----------------------------------------------------------------------------PSPS--------- R_norvegicus_ENSRNOP00000000576 ---------MASGQGPGPPK-----GDCDEA----------------------------------------------------------------------------LSAS--------- M_domestica_ENSMODP00000017616 --------------------------------------------------------------------------------------------------------------T--------- O_cuniculus_ENSOCUP00000002204 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000018457 ---------MASGQGPGPPR-----QECGEP--------------------------------------------------------------------------ALPSAS--------- A_carolinensis_ENSACAP00000016202 --------------------------------------------------------------------------------------------------------------A--------- G_gallus_ENSGALP00000039057 ---------MEGNEGDPPGAHRRRDSHGRRP--------------------------------------------------------------------------SREINA--------- X_tropicalis_ENSXETP00000056677 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000001882 --------------------------------------------------------------------------------------------------------------A--------- G_aculeatus_ENSGACP00000018978 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000024313 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000089067 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000014135 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000008572 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000014770 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000010478 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000365230 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000007865 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000012163 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000022903 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000007577 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000040259 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000017211 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011187 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000017513 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000010059 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005598 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000053903 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000096467 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000020984 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000017311 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000025701 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381185 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000017121 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000086454 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000008651 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000010339 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000031936 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000003768 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006866 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002775 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000006458 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108371 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000021005 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017850 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000095258 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000056470 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000000778 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005643 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000002093 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000024813 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000014671 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000000102 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000026248 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000008404 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010457 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000052058 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250405 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000001415 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000019355 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000022806 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013488 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000044048 MFGLRRNAVIGLNLYCGGASLGAG--GGSPA-GARLVA--E----EAKARRE-GG----GE---------------AALLPGARVVARPPPVGAEDPDVTASAERRLHKSPGLLAVPPEE M_mulatta_ENSMMUP00000005209 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000017662 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000032199 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000293288 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000036334 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000017160 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000017228 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000012873 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000033093 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000004550 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000024241 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000019323 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018700 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000023687 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000015983 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000002788 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018053 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000010122 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000006084 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000028328 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000023449 ---FKKNAVIGLNLYCGGAGMGAGGGASGPPSGGRLLASGKGPTVESTPPQRDGGEVETGTAGAGLIGGGIRASPPNPVSPGARGVARPAPIGAEAPDVTTDPMPSLF-APGRCSSAPAE B_taurus_ENSBTAP00000020159 MFGLKRNAVIGLNLYCGGAGLGQGS-GASSP-GGRLLAAGK----EATARREVGG----GEAGT-VIGGSAGPSPPATLAPDARRVARPSPIGAEGPDVTATPTRLLFFAPTRLASPPEE T_rubripes_ENSTRUP00000006891 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005841 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000017739 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000018321 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010452 MFSLRRNAVIGLNLYLGGPGLGAGGGGVAPP-AERLLAAEK----EAAARLEVGG----GEAGA-VIGGSPGASPPAALAPDARRVARPAPIGAELPDVSATPARLLYLAPTRRASPLEE E_caballus_ENSECAP00000016379 MFGLKRNAVIGLNLYCGGAGLGAGGGGASSP-GGRLLAAGK----EATARREGGG----GEAGA-VIGGSAGGSPQTTLAPDSLRVARPSPIGAEGPDVTAPSSRLLFFAPTRCASPPEG C_familiaris_ENSCAFP00000017738 MFGLKRNAVIGLNLYCGGAGLGAGSGGASSS-GGRLLASGK----EATTRREGGG----GEAGA-VIGGSAGASPPTTLAPDARRVARPSPIGAEGPNVSATPPRLLLLAPPCRASPPEE G_gorilla_ENSGGOP00000015756 MFGLKRNAVIGLNLYCGGAGLGAGSGGATXP-GGRLLATEK----EASARREIGG----GEAGA-VIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEE P_pygmaeus_ENSPPYP00000001046 MFGLKRNAVIGLNLYCGGAGLGAGSGGATPP-GGRLLATEK----EASARREIGG----GEAGA-VIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLFFFAPTRRAAPLEE M_mulatta_ENSMMUP00000010772 MFGLKRNAVIGLNLYCGGAGLGAGSGGATPP-GGRLLATEK----EASARREIGG----GEAGT-VIGGSAGASPPAALTPDARRVARPPPIGAEVPDVTASPARLLFFAPTRRASPLEE X_tropicalis_ENSXETP00000050759 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000358022 MFGLKRNAVIGLNLYCGGAGLGAGSGGATRP-GGRLLATEK----EASARREIGG----GEAGA-VIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEE O_latipes_ENSORLP00000005745 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000002137 MFGLKRNAVIGLNLYCGG-----GSGGATPP-GGRLLATEK----EASARREIGG----GEAGA-VIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEE A_aegypti_AAEL001521-PA MLSAEAPVSHNHHLLPDRLSAPALARRKFSF--------------------------------------------------------------------------PANLHSTVLHGDPPG O_cuniculus_ENSOCUP00000005553 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000010113 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000000851 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008963 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006267 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000009257 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000040899 ------------------------------------------------------------------------------------------------------------------------ 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000363591 ---------------------------------------------------------------EEQVAQDTEEVFRSYVFYRHQQ-EQEAEGVAA-PADPEMVTLP-------------- G_gorilla_ENSGGOP00000015828 ---------------------------------------------------------------EEQVAQDTEEVFRSYVFYRHQQ-EQEAEGAAA-PADPEMVTLP-------------- P_troglodytes_ENSPTRP00000050271 ---------------------------------------------------------------EEQVAQDTEEVFRSYVFYRHQQ-EQEAEGAAA-PADPEMVTLP-------------- M_mulatta_ENSMMUP00000011943 ---------------------------------------------------------------EEQVARDTEEVFRSYVFYRHQQ-EQEAEGAAA-PADPEMDTLP-------------- P_pygmaeus_ENSPPYP00000006150 ---------------------------------------------------------------EEQVARDTEEVFRSNVFHRHQQ-EQEAEGAAA-PADPEMVTLP-------------- B_taurus_ENSBTAP00000000549 ---------------------------------------------------------------EEQVARDTEEVFRSYVFYRHQQ-EQEAEGAAA-PTDPEMVTLH-------------- E_caballus_ENSECAP00000021385 ---------------------------------------------------------------EEQVARDTEEVFRSYVYYRHQQ-EQEAEGAAA-PADPEMDTLP-------------- C_familiaris_ENSCAFP00000001449 ---------------------------------------------------------------EEQVARDTEEVFRSYVFYRHRQ-EQEAEGAAV-PADPEMVTLP-------------- M_musculus_ENSMUSP00000077757 ---------------------------------------------------------------EQQVAQDTEEVFRSYVFYLHQQ-EQETQGAAA-PANPEMDNLP-------------- R_norvegicus_ENSRNOP00000000576 ---------------------------------------------------------------EQQVAQDTEEVFRSYVFYLHQQ-EQETQGAAA-PANPEMDNLS-------------- M_domestica_ENSMODP00000017616 ---------------------------------------------------------------EEQVARETEEVFRSYVYYRHQQ-EQETEGEAV-PADPEMDTLP-------------- O_cuniculus_ENSOCUP00000002204 ----------------------------------------------------------------QQVARDTEEVFRSYVFHRHRQ-EQEAEGAAA-PADPEMISLH-------------- P_pygmaeus_ENSPPYP00000018457 ---------------------------------------------------------------EEQVARDTEEVFRSYVFYRHQQ-EQEAEGAAA-PADPEMVTLP-------------- A_carolinensis_ENSACAP00000016202 ---------------------------------------------------------------EDQVAQETEEVFQSYAFYRYQQ-EREQTEGDV-PHDPEIAAIP-------------- G_gallus_ENSGALP00000039057 ---------------------------------------------------------------EDQVAQETEEVFRSYTFYRYQQ-EREEGGAEV-PMDPEIMEIQ-------------- X_tropicalis_ENSXETP00000056677 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000001882 ---------------------------------------------------------------EGRVAEEAEEVFRSFAFYRYQQ-EREERGAEL-PRDPEIEQLQ-------------- G_aculeatus_ENSGACP00000018978 -------------------------------------MADGGREKQDDGDREPRGAEGGEDVVDDPIMEQGAVVLRGYVVSRINA-----EDPSRHVSPEQ------------------- M_domestica_ENSMODP00000024313 ------------------------------------------------------------------MSHSNRELVIDFLSYKLSQ-KGYNWSQFE--D--ENRTEVLEGA---------- D_rerio_ENSDARP00000089067 -------------------------------------MADGKNGETTD-ENELKGATGGEDVVDDAIIEQSAVLLRGYVIQQATI-----DDPNIHVSHET------------------- T_rubripes_ENSTRUP00000014135 ------------------------------------------------------------------MS-QNRELVIFYIKYKLSQ-RNYPFNHNGLILEPPSRTDG---------QFVTT B_taurus_ENSBTAP00000008572 ------------------------------------------------------------------MSQSNRELVVDFLSYKLSQ-KGYSWSQFS--DVEENRTEAPEGTE------SDM E_caballus_ENSECAP00000014770 ------------------------------------------------------------------MSQSNRELVVDFLSYKLSQ-KGYNWSQFS--DVEENRTEAPEGTE------SEM C_familiaris_ENSCAFP00000010478 ------------------------------------------------------------------MSQSNRELVVDFLSYKLSQ-KGYSWSQFS--DVEENRTEAPEGTE------SEM H_sapiens_ENSP00000365230 ------------------------------------------------------------------MSQSNRELVVDFLSYKLSQ-KGYSWSQFS--DVEENRTEAPEGTE------SEM M_mulatta_ENSMMUP00000007865 ------------------------------------------------------------------MSQSNRELVVDFLSYKLSQ-KGYSWSQFS--DVEENRTEAPEGTE------SEM P_pygmaeus_ENSPPYP00000012163 ------------------------------------------------------------------MSQSNRELVVDFLSYKLSQ-KGYSWSQFS--DVEENRTEAPEGTE------SEM P_troglodytes_ENSPTRP00000022903 ------------------------------------------------------------------MSQSNRELVVDFLSYKLSQ-KGYSWSQFS--DVEENRTEAPEGTE------SEM T_nigroviridis_ENSTNIP00000007577 -------------------------------RSHPGAKSKG--------------------ASTQRMS-LNRELVIFYIKYKLSQ-RNYPLSH---IVEPSSRTEG---------QFGTT R_norvegicus_ENSRNOP00000040259 ------------------------------------------------------------------MSQSNRELVVDFLSYKLSQ-KGYSWSQFS--DVEENRTEAPEETE------PER T_nigroviridis_ENSTNIP00000017211 ------------------------------------------------------------DVVDDPILEQGAVVLRGYVIERIHV-----EQPSLHVSSED------------------- A_carolinensis_ENSACAP00000011187 ------------------------------------------------------------------MSSSNRALVVDFLSYKLSQ-RGHSWHEIE-------MESGEEAME------PAN O_latipes_ENSORLP00000017513 --------------------------------------------------------------QAHTMSHCNRELVRFYLAYKMSC-RDYPVSLLK-PTDDGGETEEDHSDAR--NRRLVS G_gallus_ENSGALP00000010059 ------------------------------------------------------------------MSSSNRELVIDFVSYKLSQ-RGHCWSELE--EEDENRTDTA----------AEA M_domestica_ENSMODP00000005598 -------------------------------------------------------------MATPASAPDTRALVADFVGYKLRQ-KGYACG---------------------------- X_tropicalis_ENSXETP00000053903 ------------------------------------------------------------------MEGSSRDLVEKFVCKKLSQ-KGACGEFSS-NSQPKGVSNGSSEGPG-------- D_rerio_ENSDARP00000096467 --------------------------------------------------------------MANEISYDNRNIVEKYLKHKLSK-RGYVWKCQS-SAEEDDTFNKAVEESSPNSDRRLQ G_gallus_ENSGALP00000020984 ----------------------------------------M--------------------AHPGRRGYDNREIVLKYIHYKLSQ-RGYDW-------AAGEDRPPVPP--------APA A_carolinensis_ENSACAP00000017311 ----------------------------------------M--------------------AHPGIRGYDNREIVLRYIHYKLSQ-KGYDWVASG---DRGN--LAAAA-----AAAAAT B_taurus_ENSBTAP00000025701 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381185 ----------------------------------------M--------------------AHAGRTGYDNREIVMKYIHYKLSQ-RGYEW-------DAGD--VGAAP-----PGAAPA P_troglodytes_ENSPTRP00000017121 ----------------------------------------M--------------------AHAGRTGYDNREIVMKYIHYKLSQ-RGYEW-------DAGD--VGAAP-----PGAAPA M_musculus_ENSMUSP00000086454 ------------------------------------------------------------------MSQSNRELVVDFLSYKLSQ-KGYSWSQFS--DVEENRTEAPEETE------AER M_mulatta_ENSMMUP00000008651 ----------------------------------------M--------------------AHAGRTGYDNREIVMKYIHYKLSQ-RGYEW-------DAGD--VGAAT-----PGAAPA P_pygmaeus_ENSPPYP00000010339 ----------------------------------------M--------------------AHAGTTGYDNREIVDEXIHYKLSQ-RGYEW-------DAGD--VGAAP-----PGAATA X_tropicalis_ENSXETP00000031936 --------------------------RKKGNNGVKDRDWEEQHATGNIIFRGSPDKYLTEQGWMAQSELGSRALVEDFVRYKLCQ-RSLVP----------------------------- R_norvegicus_ENSRNOP00000003768 ----------------------------------------M--------------------AQAGRTGYDNREIVMKYIHYKLSQ-RGYEW-------DTGD--EDSAP-----LRAAPT T_guttata_ENSTGUP00000006866 ------------------------------------------------------------------MYSSNRELVIDFVSYKLSQ-KGYSWSQLE--EEDENRTDFAG---------EED O_cuniculus_ENSOCUP00000002775 ------------------------------------------------------------------MSQSNRELVVDFLSYKLSQ-KGYSWSQFS--DVEENRTEAPEGTG------PEM M_domestica_ENSMODP00000006458 ----------------------------------------M--------------------AHPGRRGYDNREIVMKYIHYKLSQ-RGYEW-------DAGDLRAPASPSLPPVVASAPA M_musculus_ENSMUSP00000108371 ----------------------------------------M--------------------AQAGRTGYDNREIVMKYIHYKLSQ-RGYEW-------DAGD--ADAAP-----LGAAPT O_latipes_ENSORLP00000021005 -----------------------------------------------------------------MANVSNRSIVEKYICHKLSK-RGYVCGLNG-GQRENAANNGSVGDHS-------- E_caballus_ENSECAP00000017850 ----------------------------------------M--------------------AHAGRTGYDNREIVMKYIHYKLSQ-RGYEW-------DAGD--AGAAP-----LGATPV D_rerio_ENSDARP00000095258 ------------------------------------------------------------------MSYYNRELVVFFIKYKLSQ-RNYPCNHIG-LTEDTNRTDGAEENGE-GAAGATT R_norvegicus_ENSRNOP00000056470 ---------------------------------------------------------------IPVSTPDTWALVADFVGYKLSG----------------------------------- G_gorilla_ENSGGOP00000000778 ----------------------------------------M--------------------AHAGRTGYDNREIVMKYIHYKLSQ-RGYEW-------DAGD--VGAVP-----PGAAPA G_aculeatus_ENSGACP00000005643 ------------------------------------------------------------------MS-QNRELVVFYINYKLSQ-RNLPLNHIG-LSEPPNRTGGGVEAGAAGGQRGAT T_guttata_ENSTGUP00000002093 ----------------------------------------M--------------------AHPGRRGYDNREIVLKYIHYKLSQ-RGYDW-------AAGEDRASLPP----DHSASAA C_intestinalis_ENSCINP00000024813 --------------------------------------------------------------------EQARFLLNMFIQDRAAD----------------------------------- O_anatinus_ENSOANP00000014671 -------------------------------------------------------AAPRMATPAPASVSDTRALVADFVGYKLRQ-KGF------------------------------- C_familiaris_ENSCAFP00000000102 ----------------------------------------M--------------------AHAGRTGYDNREIVMKYIHYKLSQ-RGYEW-------DAGE--AGAAP-----PGAAPA B_taurus_ENSBTAP00000026248 -------------------------------------------------------------MATPASAPDTRALVADFVGYKLRQ-KGYVCG---------------------------- E_caballus_ENSECAP00000008404 -------------------------------------------------------------MATPASAPDTRALVADFVGYKLRQ-KGYVCG---------------------------- P_troglodytes_ENSPTRP00000010457 -------------------------------------------------------------MATPASAPDTRALVADFVGYKLRQ-KGYVCG---------------------------- X_tropicalis_ENSXETP00000052058 ----------------------------------------M--------------------AHPRRGGYDHRDIVVKYIHYKLSQ-KGYEW-------EEGRQQVSAEH-----PQASAA H_sapiens_ENSP00000250405 -------------------------------------------------------------MATPASAPDTRALVADFVGYKLRQ-KGYVCG---------------------------- G_gorilla_ENSGGOP00000001415 -------------------------------------------------------------MATPASAPDTRALVADFVGYKLRQ-KGYVCG---------------------------- M_mulatta_ENSMMUP00000019355 -------------------------------------------------------------MATPASAPDTRALVADFVGYKLRQ-KGYVCG---------------------------- M_musculus_ENSMUSP00000022806 -------------------------------------------------------------MATPASTPDTRALVADFVGYKLRQ-KGYVCG---------------------------- G_aculeatus_ENSGACP00000013488 ------------------------------------------------------------------MANINRELVEFFLSYKLSQ-KNHPTSLLR-PEDAGGRTEGDKANSASVPGRGSS M_musculus_ENSMUSP00000044048 MAASAAAAIVSPEEELDGCEPEAIGKRPAVLPLLERVSEAA-KSSGADGSLPSTPPPPE--EEEDDLYRQSLEIISRYLREQATG----------------------------------- M_mulatta_ENSMMUP00000005209 MDGSGEQ---------------------------PRGG-GP--------------------TSSEQIMKTGALLLQGFIQDRAGR----MGGETPELALDP------------------- G_aculeatus_ENSGACP00000017662 -----------------------------------------------------------------MSNECNRHIVEKYICHKLSK-RGYAFGFDD-VGEEDAASNGSMVVPPPTAVRRCR T_rubripes_ENSTRUP00000032199 ------------------------------------------------------------------MSYNNRELVEHFLRYKLSQ-RNYPTSLLR-PEDTDGRTEGEKRSPGASNGLLVR H_sapiens_ENSP00000293288 MDGSGEQ---------------------------PRGG-GP--------------------TSSEQIMKTGALLLQGFIQDRAGR----MGGEAPELALDP------------------- T_rubripes_ENSTRUP00000036334 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000017160 MDGSGEQ---------------------------PRGGAGA--------------------TSSEQIMRTGAVLLQGFIQDRAGR----VAGGAPELLLDS------------------- A_carolinensis_ENSACAP00000017228 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000012873 --------------------------------------------------------------QVGMERECNRDIVENYICHKLSK-RGFAWSFED-VQDENAANNGSVVAPAPTLVRRCH M_musculus_ENSMUSP00000033093 MDGSGEQ---------------------------LGSG-GP--------------------TSSEQIMKTGAFLLQGFIQDRAGR----MAGETPELTLEQ------------------- A_carolinensis_ENSACAP00000004550 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000024241 --------------------------------------------------------------MDDYEFHYVHMLARDYLKHVQQT----------------------------------- P_troglodytes_ENSPTRP00000019323 MDGSGEQ---------------------------PRGG-GP--------------------TSSEQIMKTGALLLQGFIQDRAGR----MRGEAPELALDP------------------- G_aculeatus_ENSGACP00000018700 MASH------------------------------PGGGDQG--------------------NNKDQILELGTVLLKDFIFERVKR----HGDSTETVTRTQ------------------- D_rerio_ENSDARP00000023687 MAAP------------------------------SGGGDTG--------------------SGNDQILDLGAALLNNFVYERVRR----HGDRDAEVTRSQ------------------- T_guttata_ENSTGUP00000015983 ---------------------------------------------------------------------------------------------------EP------------------- T_nigroviridis_ENSTNIP00000002788 -----------------------------------------------------------------MAREYNRDIVEKYIFHKLSK-RGFVWRFEE-VQDQNAANNGSVVAPAPTLVRRCH G_aculeatus_ENSGACP00000018053 --------------------MEVLRRPSVMAAEVLDVFDRS--------------------LTEKELVSQSKALCRDYILSRLHQ-NGQGWSKTE------------------------- T_nigroviridis_ENSTNIP00000010122 ------------------------------------------------------------------MSYDNRELVEYFLGYKLAQ-RNYPSSLLR-PQEPDGWTEGDKKSPAAVNGLLIR G_aculeatus_ENSGACP00000006084 --------------------MDMLRRSSVFAA---EVFDRS--------------------PTDKELVSQAKALCRDYIHSRLNR-AGMGWSKPE------------------------- R_norvegicus_ENSRNOP00000028328 MDGSGDH---------------------------LGGG-GP--------------------TSSEQIMKTGAFLLQGFIQDRAER----MAGETPELTLEQ------------------- M_domestica_ENSMODP00000023449 VADGAADVPMCPEEELDGYEPEPPGKRPSRLAVLEIAREGG-DSP--NGSLPSTPPPAEEDEEEDELYGQSLELISRYLREQAVG----------------------------------- B_taurus_ENSBTAP00000020159 MESPISDAIMSPEEELDGCEPDPLGKRPAVRPLPLLVGEASNNSPGSDGSLPSTPPPAE--EEEDELYRQSLEIISQYLREQATG----------------------------------- T_rubripes_ENSTRUP00000006891 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005841 --------------------MEMLRRSSMFAA---EVFDRS--------------------PTDKELVSQAKALCRDYIHSRLNR-AGIGWSKAE------------------------- B_taurus_ENSBTAP00000017739 MDGSGEQ---------------------------PRGG-GP--------------------TSSEQIMKTGALLLQGFIQDRAGR----MGGETPELGLEQ------------------- T_nigroviridis_ENSTNIP00000018321 --------------------MEVLRRSSVFAAEVLDVFDRS--------------------LTEKELVSHSKALCRDYILSRLTQ-SGLGWSKSE------------------------- O_cuniculus_ENSOCUP00000010452 MEAPAADAIMSPEEELDGYEPEPLAKRPAVLPLLDLVGEAS-KVPSTDGSLPSTPPPAE--EEEDELYRQSLEIIARYLREQATG----------------------------------- E_caballus_ENSECAP00000016379 MEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLEFVREAS-SGPCTDGSLPSTPPPAE--EEEDELYRQSLEIISRYLREQATG----------------------------------- C_familiaris_ENSCAFP00000017738 MEGPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGEAS-SGPGMDGSLPSTPPPAE--EEEDELYRQSLEIISRYLREQATG----------------------------------- G_gorilla_ENSGGOP00000015756 MEAPAADAIMSXEEELDGYEPEPLGKRPAVLPLLELVGESG-NDTSTDGSLPSTPPPAE--EEEDELYRQSLEIISRYLREQATG----------------------------------- P_pygmaeus_ENSPPYP00000001046 MEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESG-NNTSTDGSLPSTPPPAE--EEEDELYRQSLEIISRYLREQATG----------------------------------- M_mulatta_ENSMMUP00000010772 MEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESG-NSPSTDGSLPSTPPPAE--EEEDELYRQSLEIISRYLREQATG----------------------------------- X_tropicalis_ENSXETP00000050759 MATHGAGGDYPGEDKEKNQGEGGAAGGPSLGAAGDRSG-TG--------------------VSTEQILETGELLLNGFISDRLQN-NPDVAGARALFPGST------------------- H_sapiens_ENSP00000358022 MEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESG-NNTSTDGSLPSTPPPAE--EEEDELYRQSLEIISRYLREQATG----------------------------------- O_latipes_ENSORLP00000005745 MASH------------------------------PGGGDQ---------------------EKSKELLDVGTKLLKNFICERVRR----NLQDDSEVVRQQ------------------- P_troglodytes_ENSPTRP00000002137 MEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESG-NNTSTDGSLPSTPPPAE--EEEDELYRQSLEIISRYLREQATG----------------------------------- A_aegypti_AAEL001521-PA SINSGSLQPSSTASFARRRLSNVSDVVTRKLSSTIGWKQPV--------------------LPSQDIITQGKCLCGQYIRCRLKK-SGVFNRKLG-LQR--------------------- O_cuniculus_ENSOCUP00000005553 MDGSGEQ---------------------------SRGG-GP--------------------TSSEQIMKTGALLLQGFIQDRASR----MGGQTPELAVAQ------------------- G_gorilla_ENSGGOP00000010113 MDGSGEQ---------------------------PRGG-GP--------------------TSSEQIMKTGALLLXXXXXXXXXX----XXXXXXXXXXXX------------------- A_carolinensis_ENSACAP00000000851 --------------------MDVLRRSSVFAAEVMEVFDRT--------------------PTDKELVSQAKVLCRDFIHSRLIR-AGIGWNKPE------------------------- O_anatinus_ENSOANP00000008963 --------------------MEVLRRSSVFAAEVMEVFDRS--------------------PTDKELVSQAKALCREYIHSRLIR-ASLVWSKPD------------------------- T_guttata_ENSTGUP00000006267 --------------------MEVLRRSSVFAAEVMEVFDRS--------------------PTDKELVSQAKALCRDYINSRLIQ-AGVSWSKPE------------------------- G_gallus_ENSGALP00000009257 --------------------MEVLRRSSVFAAEVMEVFDRS--------------------PTDKELVSQAKALCRDYINSRLIR-AGVSWSKPE------------------------- D_rerio_ENSDARP00000040899 ---------------------------------------MA--------------------CEASQDDQIGEALLIGVVRQELMEVMEVTEGNAAPPALPEAKPISN------------- 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000363591 -----------------------------------------------LQPSSTM---------GQVGRQLAIIGDDINRRYDSEFQTMLQHLQP-------TAENAYEYFTKIA--T--- G_gorilla_ENSGGOP00000015828 -----------------------------------------------LQPSSTM---------GQVGRQLAIIGDDINRRYDSEFQTMLQHLQP-------TAENAYEYFTKIA--T--- P_troglodytes_ENSPTRP00000050271 -----------------------------------------------LQPSSTM---------GQVGRQLAIIGDDINRRYDSEFQTMLQHLQP-------TAENAYEYFTKIA--T--- M_mulatta_ENSMMUP00000011943 -----------------------------------------------LQPSSTM---------GQVGRQLAIIGDDINRRYDSEFQTMLQHLQP-------TAENAYEYFTKIA--S--- P_pygmaeus_ENSPPYP00000006150 -----------------------------------------------LQPSSTM---------GQVGRQLAIIGDDINRRYDSEFQTMLQHLQP-------TAENTCEYFTKIA--S--- B_taurus_ENSBTAP00000000549 -----------------------------------------------PEPSSTM---------GQVGRQLAVIGDDINRRYDAEFQAMLQHLQP-------TADNAYEYFTKIA--S--- E_caballus_ENSECAP00000021385 -----------------------------------------------LEPNSTM---------GQVGRQLAIIGDDINRRYDSEFQTMLKHLQP-------TAENAYELFTKIA--S--- C_familiaris_ENSCAFP00000001449 -----------------------------------------------LEPSSTM---------GQVGRQLAIIGDDINQRYDSEFQAMLQHLQP-------TAENAYEYFTKIA--S--- M_musculus_ENSMUSP00000077757 -----------------------------------------------LEPNSIL---------GQVGRQLALIGDDINRRYDTEFQNLLEQLQP-------TAGNAYELFTKIA--S--- R_norvegicus_ENSRNOP00000000576 -----------------------------------------------LEPNSVL---------GQVGRQLALIGDDINRRYDTEFQNLLEQLQP-------TAGNAYELFTKIA--S--- M_domestica_ENSMODP00000017616 -----------------------------------------------QELSSTT---------EQVGRQLAVIGDDISRRYDSEFKAMLQHLQP-------TPDTAYEYFTKIA--SRIS O_cuniculus_ENSOCUP00000002204 -----------------------------------------------LEPNSTM---------GQVGRQLAIIGDDINQRYDSDFQNMLEKLQP-------TAENAYELFTKIALSS--- P_pygmaeus_ENSPPYP00000018457 -----------------------------------------------LQPS-------------------------------------------------------YEYFTKIA--S--- A_carolinensis_ENSACAP00000016202 -----------------------------------------------HEPNSTN---------CQVGRRLATIGDDINARYDKEFSEMLKSLQP-------TKDNAYEYFIRIA--S--- G_gallus_ENSGALP00000039057 -----------------------------------------------QELGSTG---------SQVGRRLAIIGDDINKRYDAEFRHMLKSLQP-------TKENAYEYFTTIA--S--- X_tropicalis_ENSXETP00000056677 ---------------------------------------------------XNL---------ISVGQQLAKIGDDINERYQEQFDDILKHLNP-------SLDNAYSYFKKIA--S--- T_guttata_ENSTGUP00000001882 -----------------------------------------------QDPCSTE---------SQVGQRLAIIGDDIYKRYDAEF-SMLESLQP-------TRDN--------------- G_aculeatus_ENSGACP00000018978 -----------------------------------------LGGRPNEHQDPQI---------KEVVKQLMKIADEMNR--NAELQRLISQV---------PGNCAQDIFMKVA--K--- M_domestica_ENSMODP00000024313 EIPSTV---NGSPSWHPADSRA-------------------VSGA--TGHSSSL-DAHETIPVAAVKQALREAGDEFELRYRRAFSDLTSQLHI-------TPGTAYQSFEQVV--N--- D_rerio_ENSDARP00000089067 -----------------------------------------LGGRPQDEEDPQI---------KEVVDQLLKIADDLNK--NAELQHLISTV---------QSNCAQDVFMTVA--R--- T_rubripes_ENSTRUP00000014135 QFNGTF---NGASPGTPPA----------------------------TSLATSL---------DTVKEALRDTGNEFELRYTCAFSDLHNQLHI-------TPATAYQSFENVM--D--- B_taurus_ENSBTAP00000008572 ETPSAI---NGNASWHLADSPA-------------------VNGA--TGHSRSS-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHI-------TPGTAYQSFEQVV--N--- E_caballus_ENSECAP00000014770 ETPSAI---NGNPSWHLADSPT-------------------GNGA--TGHSSSL-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHI-------TPGTAYQSFEQVV--N--- C_familiaris_ENSCAFP00000010478 ETPSAI---NGNPSWHLADSPA-------------------VNGA--TGHSSSL-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHI-------TPGTAYQSFEQVV--N--- H_sapiens_ENSP00000365230 ETPSAI---NGNPSWHLADSPA-------------------VNGA--TGHSSSL-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHI-------TPGTAYQSFEQVV--N--- M_mulatta_ENSMMUP00000007865 ETPSAI---NGNPSWHLVDSPA-------------------VNGA--TGHSSSL-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHI-------TPGTAYQSFEQVV--N--- P_pygmaeus_ENSPPYP00000012163 ETPSAI---NGNPSWHLADSPA-------------------VNGA--TGHSSSL-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHI-------TPGTAYQSFEQVV--N--- P_troglodytes_ENSPTRP00000022903 ETPSAI---NGNPSWHLADSPA-------------------VNGA--TGHSSSL-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHI-------TPGTAYQSFEQVV--N--- T_nigroviridis_ENSTNIP00000007577 QSNGTF---NGASPGTPPA----------------------PSQH--QQSLTSL---------DAVKEALRDTGNEFELRYTCAFSDLHNQLHI-------TPATAYQSFENVM--D--- R_norvegicus_ENSRNOP00000040259 ETPSAI---NGNPSWHLADSPA-------------------VNGA--TGHSSSL-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHI-------TPGTAYQSFEQVV--N--- T_nigroviridis_ENSTNIP00000017211 -----------------------------------------LGGRSEEQRDPQT---------KEVVEQLLKIADDLNR--NAEFQHLVSQV---------QGNCAQDVFMQVA--R--- A_carolinensis_ENSACAP00000011187 ETGNTL---NGSPSWHPSPSHV-------------------INGA--SEHPELLEEEEEENPRVDVSQTLREAGDEFELRYRRAFSDLTSQLHI-------TLGTAYQSFEQVV--N--- O_latipes_ENSORLP00000017513 SEDGR------------------------------------LRRS--CPCCASM---------DAIKSTLKDSADEFERRFHQGFSDLSVQLHI-------TPDTAYQNFKRVL--D--- G_gallus_ENSGALP00000010059 EMDSVL---NGSPSWHPPAGHV-------------------VNGA--TVHRSSL-EVHEIVRASDVRQALRDAGDEFELRYRRAFSDLTSQLHI-------TPGTAYQSFEQVV--N--- M_domestica_ENSMODP00000005598 ---------------------------------------------TGPGEGPTT---------EPLHRAMRAAGDEFESRFRRTFSDLAAQLHV-------TPGSAQQRFTQVS--D--- X_tropicalis_ENSXETP00000053903 -----------------------------------------------ATQGIVG---------EEVLQALLDASEEFELRYQRAFSDLTAQLHL-------TQDTAQQSFQQVV--G--- D_rerio_ENSDARP00000096467 A----------------------------------------PSAGGGNNSECLIARVTRSDPHLRLYRVLRDAGDEIERIYQREFEEMSQQMVF-------NPNSAQRSFLTVA--E--- G_gallus_ENSGALP00000020984 PAAAPAAVAAAGAS-------------SHHRPEPPG-SAAASEVPPAEGLRPAP---------PGVHLALRQAGDEFSRRYQRDFAQMSGQLHL-------TPFTAHGRFVAVV--E--- A_carolinensis_ENSACAP00000017311 PSAPTVS--------------------ASLSPELLN-SDPVSTNAPREEPDPVP---------QVVHTTLRQAGDEFSRRYRRDFAQMSGQLHL-------TPSTARSRFVAVV--E--- B_taurus_ENSBTAP00000025701 --------------------------PSRTSPPPP------PAAAAGPAPSPVP---------PVVHLTLRQAGDDFSRRYRRDFAEMSSQLHL-------TPFTARGRFATVV--E--- H_sapiens_ENSP00000381185 PGIFSSQPGHTPHPAASRD------PVARTSPLQTP-AAP--GAAAGPALSPVP---------PVVHLTLRQAGDDFSRRYRRDFAEMSSQLHL-------TPFTARGRFATVV--E--- P_troglodytes_ENSPTRP00000017121 PGIFSSQPGHTPHPAASRD------PVARTSPLQTP-AAP--GAAAGPALSPVP---------PVVHLTLRQAGDDFSRRYRRDFAEMSSQLHL-------TPFTARGRFATVV--E--- M_musculus_ENSMUSP00000086454 ETPSAI---NGNPSWHLADSPA-------------------VNGA--TGHSSSL-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHI-------TPGTAYQSFEQVV--N--- M_mulatta_ENSMMUP00000008651 PGIFSSQPGHTPHPAASRD------PVARTSPLPTP-AAPAAAAAAGPALSPVP---------PVVHLTLRQAGDDFSRRYRRDFAEMSSQLHL-------TPFTARGRFATVV--E--- P_pygmaeus_ENSPPYP00000010339 PGIFSSQPGHTPHPAASRD------P-ARTSPLPTP-AAP--GAAVGPALSPVP---------PVVHLTLRQAGDDFSRRYRRDFAEMSSQLHL-------TPFTARGRFATVV--E--- X_tropicalis_ENSXETP00000031936 -----------------------------------------------EPAGAAS---------CSLHSAMRAAGDEFEERFRQAFSEISTQIHV-------TPGTAYARFAEVA--G--- R_norvegicus_ENSRNOP00000003768 PGIFSFQPESNRTPAVHRD------TAARTSPLRPL------VATAGPALSPVP---------PVVHLTLRRAGDDFSRRYRRDFAEMSSQLHL-------TPFTARGRFATVV--E--- T_guttata_ENSTGUP00000006866 EMDGVL---NGSPSWHAATSHI-------------------VNGA--TVHQNSL-EVHEIRRAADVRQALREAGDEFELRYRRAFSDLTSQLHI-------TPSTAYQSFEQVV--N--- O_cuniculus_ENSOCUP00000002775 ETPSAI---NGNPAWHPADSPA-------------------VNGA--TGHSSSL-DAREVIPMTAVKQALREAGDEFELRYRRAFSDLTSQLHI-------TPGTAYQSFEQVV--N--- M_domestica_ENSMODP00000006458 VGIFSTQPRNTPLPAEPQDSATSTTAAARNSPLPLPPPAVAAAAAAGPTVSPVP---------PVVHLTLRQAGDDFSRRYRRDFDEMSGQLHL-------TPVTARGRFATVV--E--- M_musculus_ENSMUSP00000108371 PGIFSFQPESNPMPAVHRD------MAARTSPLRPL------VATAGPALSPVP---------PVVHLTLRRAGDDFSRRYRRDFAEMSSQLHL-------TPFTARGRFATVV--E--- O_latipes_ENSORLP00000021005 -----------------------------------------------PTPADPL---------ADIHRVLREAGDELERLYQRDFTEMSRQLYL-------TSTTAKTRFAEVI--D--- E_caballus_ENSECAP00000017850 PGIFSSQPGRTPAP-------------ARTSPLLPP-AAP--AGAAGPALSPVP---------PVVHLTLRQAGDDFSRRYRRDFAEMSSQLHL-------TPFTARGRFATVV--E--- D_rerio_ENSDARP00000095258 LVNGTMNRTNASSTGTPPQSPASS-----------------PQRQ--TNGSGGL---------DAVKEALRDSANEFELRYSRAFNDLSSQLHI-------TPATAYQSFESVM--D--- R_norvegicus_ENSRNOP00000056470 ---------------------------------------------AGPGKGPAA---------DLLHQAMHAAGDEFETRFRYTFSDLATQQHV-------TPGSAQQRFTQVS--D--- G_gorilla_ENSGGOP00000000778 PGIFSSQPGHTPHPAASRD------RVARTSPLQTP-AAP--GAAAGPALSPVP---------PVVHLTLRQAGDDFSRRYRRDFAEMSSQLHL-------TPFTARGRFATVV--E--- G_aculeatus_ENSGACP00000005643 HSNGTF---NGTSPGTPPASPL-------------------LQQR--SPSTASL---------DAVKEALRDSANEFELRYARAFSDLHNQLHI-------TPATAYQSFEDVM--D--- T_guttata_ENSTGUP00000002093 AAIAAAAIAAAGTSDHTGL--------VSPHPEPPG-SATASHTPPAEGLRPAP---------QAVHLVLRQAGDEFSRRYQRDFSQMSGQLHL-------TPFTARSRFVAVV--E--- C_intestinalis_ENSCINP00000024813 -----------------------------------------MSPQSAGFTDENL---------SDIAVTLRRIGDDMSR--DIQLNRFIDQV---------PLKSTKDIFIKVC--L--- O_anatinus_ENSOANP00000014671 -----------------------------------------------------A---------QPLHRAMRAAGDEFESRFRRAFSDLASQLHV-------TPGSAQQRFTQVS--D--- C_familiaris_ENSCAFP00000000102 PGI-------------------------------------------SASXSPVP---------PVVHLTLRQAGDDFSRRYRR-FAEMSSQLHL-------TPFTARGRFATVV--E--- B_taurus_ENSBTAP00000026248 ---------------------------------------------AGPGEGPAA---------DPLHQAMRAAGDEFETRFRRTFSDLAAQLHV-------TPGSAQQRFTQVS--D--- E_caballus_ENSECAP00000008404 ---------------------------------------------AGPGEGPAA---------DPLHQAMRAAGDEFETRFRRTFSDLAAQLHV-------TPGSAQQRFTQVS--D--- P_troglodytes_ENSPTRP00000010457 ---------------------------------------------AGPGEGPAA---------DPLHQAMRAAGDEFETRFRRTFSDLAAQLHV-------TPGSAQQRFTQVS--D--- X_tropicalis_ENSXETP00000052058 ISNYSDD---GEMPAASAD--------SRGPPQSSLASAAASSDEETPTMQPVP---------PAVLQTLSRAGDEFSRLYQQDFRQISGLLHL-------TPSTVRVRFATVV--E--- H_sapiens_ENSP00000250405 ---------------------------------------------AGPGEGPAA---------DPLHQAMRAAGDEFETRFRRTFSDLAAQLHV-------TPGSAQQRFTQVS--D--- G_gorilla_ENSGGOP00000001415 ---------------------------------------------AGPGEGPAA---------DPLHQAMRAAGDEFETRFRRTFSDLAAQLHV-------TPGSAQQRFTQVS--D--- M_mulatta_ENSMMUP00000019355 ---------------------------------------------AGPGEGPAA---------DPLHQAMRAAGDEFETRFRRTFSDLAAQLHV-------TPGSAQQRFTQVS--D--- M_musculus_ENSMUSP00000022806 ---------------------------------------------AGPGEGPAA---------DPLHQAMRAAGDEFETRFRRTFSDLAAQLHV-------TPGSAQQRFTQVS--D--- G_aculeatus_ENSGACP00000013488 AGQP-------------------------------------GMSSPPPPPSGDT---------EAVKAALQDSANEFELLFTQAFSDLSLQLDV-------TPDTAYHSFKSVM--D--- M_musculus_ENSMUSP00000044048 ----------------------------------------SKDSKPLGEAGAAG---------RRALETLRRVGDGVQRNHETAFQGMLRKLDI-------KNEGDVKSFSRVM--V--- M_mulatta_ENSMMUP00000005209 -----------------------------------------------VPQDAST---------KRLSECLKRIGDELDS--NMELQRMIAAV---------DTDSPREVFFRVA--A--- G_aculeatus_ENSGACP00000017662 EAGP----DGESFP---------------------------RLCKRLPQSDPTA---------AATHRVLREAGDELERLYQPDFTEMSRQLYL-------TSTTAQRRFAEVI--D--- T_rubripes_ENSTRUP00000032199 SRNR-------------------------------------GGAS--PSAGAGI---------EAVNAALRDSAEEFEKLFAQAFSDLSSQLDI-------TPDTAYQSFKNVM--D--- H_sapiens_ENSP00000293288 -----------------------------------------------VPQDAST---------KKLSECLKRIGDELDS--NMELQRMIAAV---------DTDSPREVFFRVA--A--- T_rubripes_ENSTRUP00000036334 -------------------------------------------------SDPNH---------KKLAQCLQKIGDELDG--NMELQRMINDS---------ALKPTKDMFMKVA--L--- M_domestica_ENSMODP00000017160 -----------------------------------------MGDSAPLPSDPRT---------KRLTECLRRIGDELDS--NMELQRMIAAV---------ETDSPREVFFRVA--A--- A_carolinensis_ENSACAP00000017228 --------------------------------------------------DPKT---------KQLSECLRRIGDELDG--NMELQSMIEQV---------QVYPPKEVFFRVA--A--- T_rubripes_ENSTRUP00000012873 EAGTGPDRDRGSIS---------------------------HPCKE-PPASDQH---------AAIHRVLREAGDELERLYQPDFTEMSRQLYL-------SSTTAQRRFAEVI--D--- M_musculus_ENSMUSP00000033093 -----------------------------------------------PPQDAST---------KKLSECLRRIGDELDS--NMELQRMIADV---------DTDSPREVFFRVA--A--- A_carolinensis_ENSACAP00000004550 -------------------------------------------GAEASPDAAAV---------TSLQDCMFRIWQELSS--NRDLTSMVESA---------TGKNPLEVLADVS--E--- M_domestica_ENSMODP00000024241 -----------------------------------------------PPLGSCL---------NKTSQILQKVAFSVQQEVEKDMETCLSTLDIV------SVESARRIFNSVM--K--- P_troglodytes_ENSPTRP00000019323 -----------------------------------------------VPQDAST---------KKLSECLKRIGDELDS--NMELQRMIAAV---------DTDSPREVFFRVA--A--- G_aculeatus_ENSGACP00000018700 -----------------------------------------LGGV--ELSDPNH---------KKLAMCLQQIGDELDG--NVELQRMMNDS---------SLGPTKDVFLKVA--F--- D_rerio_ENSDARP00000023687 -----------------------------------------LGGV--ELCDPSH---------KRLAQCLQQIGDELDG--NAQLQSMLNNS---------NLQPTQDVFIRVA--R--- T_guttata_ENSTGUP00000015983 -----------------------------------------------QPSSPDT---------KRLSECLRRIGDELDS--NMELQRMIEQV---------GCDAPKKLFFRVA--K--- T_nigroviridis_ENSTNIP00000002788 EAGTGP--DRGSIP---------------------------HLCKR-TPQSEQH---------AAIHRVLREAGDELERLYQPDFTEMSRQLYL-------TSTTAQRRFAEVI--D--- G_aculeatus_ENSGACP00000018053 --------------------------------------------LHLSPSSAAL---------AEVSLVLLCLGDELESIRPSLYRNVARQLNISVA----MENMVSDAFIGVA--T--- T_nigroviridis_ENSTNIP00000010122 NRSR-------------------------------------SGAS--ASTGAGV---------EAVHAALRDSAEEFEKLFAQAFSDLSSQLVI-------TPDTAYQSFKNVM--D--- G_aculeatus_ENSGACP00000006084 --------------------------------------------SGRAAPGGGL---------GDVSSALLWLGDELEYLRPNVYRNVARQLNITVA----SESIVSDAFLAVA--A--- R_norvegicus_ENSRNOP00000028328 -----------------------------------------------PPQDAST---------KKLSECLRRIGDELDN--NMELQRMIADV---------DTDSPREVFFRVA--A--- M_domestica_ENSMODP00000023449 ----------------------------------------TKEAKPL-----RS---------GKALETLRRVGDGVQRNHERAFQGMLRKLDI-------KNEEDIKAVSRVA--T--- B_taurus_ENSBTAP00000020159 ----------------------------------------AKDAKPLGGSGTTS---------RKALETLRRVGDGVQRNHETAFQGMLRKLDI-------KNEDDVKSLSRVM--V--- T_rubripes_ENSTRUP00000006891 -----------------------------------------------------------------------------------LLLSLVNQV---------QGNCAQEVFMQVA--R--- T_nigroviridis_ENSTNIP00000005841 --------------------------------------------NGPPASGGTL---------GEASAVLLWLGDELEHLRPNVYCNVARQLNITVA----SESIMSDAFLAVA--A--- B_taurus_ENSBTAP00000017739 -----------------------------------------------VPQDAST---------KKLSECLKRIGDELDS--NMELQRMIAAV---------DTDSPREVFFRVA--A--- T_nigroviridis_ENSTNIP00000018321 --------------------------------------------LNLSPSSTAL---------ADASMVLLCLGDELESMQPSLYRNVARQLNISVA----MENMVSDAFIAVA--T--- O_cuniculus_ENSOCUP00000010452 ----------------------------------------AKDAKPMGRAGSAS---------RKALETLRRVGDGVQRNHETAFQGMLRKLDI-------KNEDDVKSLSRVM--V--- E_caballus_ENSECAP00000016379 ----------------------------------------TKDTKPMGGSGAAS---------RKALETLRRVGDGVQRNHETAFQGMLRKLDI-------KNEDDVKSLSRVM--A--- C_familiaris_ENSCAFP00000017738 ----------------------------------------AKDAKPLGGSRAAS---------RKALETLRRVGDGVQRNHETAFQGMLRKLDI-------KNEDDVKSLSRVI--V--- G_gorilla_ENSGGOP00000015756 ----------------------------------------AKDTKPMGRSGATS---------RKALETLRRVGDGVQRNHETAFQGMLRKLDI-------KNEDDVKSLSRVM--I--- P_pygmaeus_ENSPPYP00000001046 ----------------------------------------AKDTKPLGRSGATC---------RKALETLRRVGDGVQRNHETAFQGMLRKLDI-------KNEDDVKSLSRVM--V--- M_mulatta_ENSMMUP00000010772 ----------------------------------------AKDTKPMGRSGATS---------RKALETLRRVGDGVQRNHETAFQGMLRKLDI-------KNEDDVKSLSRVM--V--- X_tropicalis_ENSXETP00000050759 -----------------------------------------------QHSDPSI---------KRLSECLRKIGDELDA--NIELQRRIECV---------PCNSPKQVFFHVA--K--- H_sapiens_ENSP00000358022 ----------------------------------------AKDTKPMGRSGATS---------RKALETLRRVGDGVQRNHETAFQGMLRKLDI-------KNEDDVKSLSRVM--I--- O_latipes_ENSORLP00000005745 -----------------------------------------LGAE--ELVDPNH---------KRLAQCLQQIGDELDG--NVELKRLIDDS---------SLSPSKEVFLKVA--L--- P_troglodytes_ENSPTRP00000002137 ----------------------------------------AKDTKPMGRSGATS---------RKALETLRRVGDGVQRNHETAFQGMLRKLDI-------KNEDDVKSLSRVM--I--- A_aegypti_AAEL001521-PA -----------------------------------------IRSIVGTPTIHVV---------REVFPALLSVGEELERMYPRVYNGVARQLSRIGRGELKTPETAPVLLSAIA--R--- O_cuniculus_ENSOCUP00000005553 -----------------------------------------------GPQDEST---------KKLSECLKRIGDELDS--NMELQRMIAAV---------DTDSPREVFFRVA--A--- G_gorilla_ENSGGOP00000010113 -----------------------------------------------XXXXXST---------KKLSECLKRIGDELDS--NMELQRMIAAV---------DTDSPREVFFRVA--X--- A_carolinensis_ENSACAP00000000851 --------------------------------------------HSVPVPGGKL---------AEVSNILLRLGDELEYIRPNLYRNVARQLNISLH----SETVVTDAFLAVA--T--- O_anatinus_ENSOANP00000008963 --------------------------------------------YNVPSPGGKL---------AEVSTILLRLGDELEYIRPNVYRNIARQLNISLH----SETVVTDAFLAVA--T--- T_guttata_ENSTGUP00000006267 --------------------------------------------YNAPVPGGKL---------AEVSTILLRLGDELEYIRPNVYRNIARQLNISLH----SETVVSDAFLAVA--T--- G_gallus_ENSGALP00000009257 --------------------------------------------HNTPVPGGKL---------AEVSAILLCLGDELEYIRPNVYRNIARQLNISLH----SETVVTDAFLAVA--A--- D_rerio_ENSDARP00000040899 -----------------------------------------------SQDQILV---------QQLANTIKVIGDKLDQ--DQAFNDMIDGL---------VKVADKSSFWKLV--E--- 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000363591 ---S----LFESG-INWGRVVALLGFGYRLALHVY-QHGLTGF--L---GQVTRFVVDFMLHHCIARWIAQRGGWV-AALN--------------------------------------- G_gorilla_ENSGGOP00000015828 ---S----LFESG-INWGRVVALLGFGYRLALHVY-QHGLTGF--L---GQVTRFVVDFMLHHCIARWIAQRGGWV-AALN--------------------------------------- P_troglodytes_ENSPTRP00000050271 ---S----LFESG-INWGRVVALLGFGYRLALHVY-QHGLTGF--L---GQVTRFVVDFMLHHCIARWIAQRGGWV-AALN--------------------------------------- M_mulatta_ENSMMUP00000011943 ---SS--VLFESG-INWGRVVALLGFGYRLALHVY-QHGLTGF--L---GQVTRFVVDFMLHHCIARWIAQRGGWV-AALN--------------------------------------- P_pygmaeus_ENSPPYP00000006150 ---S----LFESG-INWGRVVALLGFGYRLALHVY-HRGLTGF--L---GQVTRFVVDFMLHHCIARWIAQRGGWV-AALN--------------------------------------- B_taurus_ENSBTAP00000000549 ---S----LFESG-INWGRVVALLGFGYRLALHVY-QRGLTGF--L---GQVTRFVADFMLRRSIARWIAQRGGWV-AALD--------------------------------------- E_caballus_ENSECAP00000021385 ---S----LFESG-INWGRVVALLGFGYRLALHVY-QRGLTGF--L---SQLTRFVAEFMLHHCIARWIAQRGGWV-AALD--------------------------------------- C_familiaris_ENSCAFP00000001449 ---RCHLFLFESG-INWGRVVALLGFGYRLALHVY-QRGLTGF--L---GQVTRFVADFMLHHCIARWIAQRGGWV-AALN--------------------------------------- M_musculus_ENSMUSP00000077757 ---S----LFKSG-ISWGRVVALLGFGYRLALYVY-QRGLTGF--L---GQVTCFLADIILHHYIARWIAQRGGWV-AALN--------------------------------------- R_norvegicus_ENSRNOP00000000576 ---S----LFKSG-ISWGRVVALLGFGYRLALYVY-QRGLTGF--L---GQVTCFLADIILHHYIARWIAQRGGWV-AALS--------------------------------------- M_domestica_ENSMODP00000017616 APHS----LFESG-INWGRVVALLGFGYRLALHVY-QRGLTGF--L---GRVAHFVADFMLHHCIARWIAQNGGWV-AALN--------------------------------------- O_cuniculus_ENSOCUP00000002204 ---D----LFESG-INWGRVVALLAFGYRLALYIY-RRGLTGF--L---GQVTRFVADFVVHHCIAQWIAQRGGWV-AVLS--------------------------------------- P_pygmaeus_ENSPPYP00000018457 ---S----LFESG-INWGRVVALLGFGYRLALHVY-QRGLTGF--L---GQVTRFVVDFMLHHCIARWIAQRGGWV-AALN--------------------------------------- A_carolinensis_ENSACAP00000016202 ---S----LFESG-INWGRVIALLGFGYRMAIHVY-QHGMTGF--L---RRIARYMADFVLRNRIARWIAQQGGWV-AALD--------------------------------------- G_gallus_ENSGALP00000039057 ---S----LFDSG-INWGRVIALLGFGYCMAIHVY-QQGITGF--L---RRIARYVTEFMLRNRIARWIAQQGGWV-AALD--------------------------------------- X_tropicalis_ENSXETP00000056677 ---S----LFENG-INWGRILSLLGFGYRMAVYVV-RNGQRGF--F---RIINQWMVRYVMESCIAQWISSRGGWV-AFFQ--------------------------------------- T_guttata_ENSTGUP00000001882 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018978 ---S----IFDDG-INWGRVVALFHLAYRLIYRAL-TTNHLEN--I---RIIIGWVLRF-IRERLYPWLVQQGGWV-GVIN--------------------------------------- M_domestica_ENSMODP00000024313 ---E----LFRDG-VNWGRIVAFFSFGGALCVESV-DKEMEVL--V---GRITSWMATY-LDDHLDPWIQENGGWD-TFVE----------------------------LYGNDAAAESR D_rerio_ENSDARP00000089067 ---S----IFDDG-INWGRVVALFHLAYRLIFQAL-TQNHLEI--I---KNIISWFLQF-MKKHISAWIRQQGGWE-GIFR--------------------------------------- T_rubripes_ENSTRUP00000014135 ---E----VFRDG-VNWGRIVGLFAFGGALCVECV-EKEMSPL--V---GRIIEWMTVY-LDNHIQPWIQSQGGWV-RFAE----------------------------LFGQDAAAESR B_taurus_ENSBTAP00000008572 ---E----LFRDG-VNWGRIVAFFSFGGALCVESV-DKEMQVL--V---SRIATWMATY-LNDHLEPWIQENGGWD-TFVE----------------------------LYGNNAAAESR E_caballus_ENSECAP00000014770 ---E----LFRDG-VNWGRIVAFFSFGGALCVESV-DKEMQVL--V---SRIATWMATY-LNDHLEPWIQENGGWD-TFVE----------------------------LYGNNAAAESR C_familiaris_ENSCAFP00000010478 ---E----LFRDG-VNWGRIVAFFSFGGALCVESV-DKEMQVL--V---SRIAAWMATY-LNDHLEPWIQENGGWD-TFVE----------------------------LYGNNAAAESR H_sapiens_ENSP00000365230 ---E----LFRDG-VNWGRIVAFFSFGGALCVESV-DKEMQVL--V---SRIAAWMATY-LNDHLEPWIQENGGWD-TFVE----------------------------LYGNNAAAESR M_mulatta_ENSMMUP00000007865 ---E----LFRDG-VNWGRIVAFFSFGGALCVESV-DKEMQVL--V---SRIAAWMATY-LNDHLEPWIQENGGWD-TFVE----------------------------LYGNNAAAESR P_pygmaeus_ENSPPYP00000012163 ---E----LFRDG-VNWGRIVAFFSFGGALCVESV-DKEMQVL--V---SRIAAWMATY-LNDHLEPWIQENGGWD-TFVE----------------------------LYGNNAAAESR P_troglodytes_ENSPTRP00000022903 ---E----LFRDG-VNWGRIVAFFSFGGALCVESV-DKEMQVL--V---SRIAAWMATY-LNDHLEPWIQENGGWD-TFVE----------------------------LYGNNAAAESR T_nigroviridis_ENSTNIP00000007577 ---E----VFRDG-VNWGRIVGLFAFGGALCVECV-EKEMNPL--V---GRIIEWMTVY-LDNHIQPWIQSQGGWE-RFAE----------------------------LFGQDAAAESR R_norvegicus_ENSRNOP00000040259 ---E----LFRDG-VNWGRIVAFFSFGGALCVESV-DKEMQVL--V---SRIASWMATY-LNDHLEPWIQENGGWV-RTTP----------------------------LVCPPLVCLSS T_nigroviridis_ENSTNIP00000017211 ---S----IFADG-INWGRVVALFHLAYRLILKAL-TTNHLEN--I---RTVIGWVLQV-IREQLYSWLVQQGGWA-GVIQ--------------------------------------- A_carolinensis_ENSACAP00000011187 ---E----LFHDG-VNWGRIVAFFSFGGALCVESV-DKEMQGL--V---VRIASWMTTY-LTEHLDPWIQENGGWE-RFVD----------------------------VYGNDAAAKSR O_latipes_ENSORLP00000017513 ---E----LFKDG-INWGRVVGLFVFGGALCVECV-ERNMGEL--V---SRIAEWMTQY-LDEQISPWIHSHGGWD-CFAR----------------------------LYGQNGAAEAR G_gallus_ENSGALP00000010059 ---E----LFHDG-VNWGRIVAFFSFGGALCVESV-DKEMRVL--V---GRIVSWMTTY-LTDHLDPWIQENGGWE-RFVD----------------------------LYGNNAAAELR M_domestica_ENSMODP00000005598 ---E----LFQGG-PNWGRLVAFFVFGAALCAESV-NKEMEPL--V---GQVQDWMVTY-LETQLADWIHSSGGWA-EFTA----------------------------LYGDGALEEAR X_tropicalis_ENSXETP00000053903 ---E----LFRDG-TNWGRIVAFFSFGRALCVESA-NKEMTEL--L---PRIVQWMVQY-LEHTLQPWMLENGGWE-AFVG----------------------------LYGKGAAAQSR D_rerio_ENSDARP00000096467 ---E----LFRDG-VNWGRIIAFFEFGGTMCVESV-NREMASQ--V---DNIAHWMTDY-LNGPLENWIEENGGWD-AFVE----------------------------MYGQQRDSVFH G_gallus_ENSGALP00000020984 ---E----LFRDG-VNWGRIVAFFEFGGVMCVESV-NREMSPL--V---DNIATWMTEY-LNRHLHNWIQDNGGWD-AFVE----------------------------LYGNSMRPLFD A_carolinensis_ENSACAP00000017311 ---E----LFQDG-VNWGRIVAFFEFGGMLCVESV-SREMSPL--V---DNIATWMTEY-LNQYLRNWIQENGGW--------------------------------------------- B_taurus_ENSBTAP00000025701 ---E----LFRDG-VNWGRIVAFFEFGGVMCVESV-NREMSPL--V---DSIALWMTEY-LNRHLHTWIQDNGGWV-GARL----------------------------DVSLSGTPRSQ H_sapiens_ENSP00000381185 ---E----LFRDG-VNWGRIVAFFEFGGVMCVESV-NREMSPL--V---DNIALWMTEY-LNRHLHTWIQDNGGWD-AFVE----------------------------LYGPSMRPLFD P_troglodytes_ENSPTRP00000017121 ---E----LFRDG-VNWGRIVAFFEFGGVMCVESV-NREMSPL--V---DNIALWMTEY-LNRHLHTWIQDNGGWD-AFVE----------------------------LYGPSMRPLFD M_musculus_ENSMUSP00000086454 ---E----LFRDG-VNWGRIVAFFSFGGALCVESV-DKEMQVL--V---SRIASWMATY-LNDHLEPWIQENGGW----------------------------------------GVSGG M_mulatta_ENSMMUP00000008651 ---E----LFRDG-VNWGRIVAFFEFGGVMCVESV-NREMSPL--V---DNIALWMTEY-LNRHLHTWIQDNGGWD-AFVE----------------------------LYGPSMRPLFD P_pygmaeus_ENSPPYP00000010339 ---E----LFRDG-VNWGRIVAFFEFGGVMCVESV-NREMSPL--V---DNIALWMTEY-LNRHLHTWIQDNGGWD-AFVE----------------------------LYGPSMRPLFD X_tropicalis_ENSXETP00000031936 ---S----LFQGG