10        20        30        40        50        60        70        80        90       100       110       120
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000364878                 ---------------------------------------------------------------------------MADEKPSNGVLVHMVKLLIKTFLDG--IFDDLMENNVLNTDEI--
P_troglodytes_ENSPTRP00000047678          ---------------------------------------------------------------------------MADEKPSNGVLVHMVKLLIKTFLDG--IFDDLMENNVLNTDEI--
P_pygmaeus_ENSPPYP00000004372             ---------------------------------------------------------------------------FTDEKPSNGVPVHMVKLLIRTFLDG--IFDDLMENNVLNTDEI--
M_mulatta_ENSMMUP00000021744              ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000006810             ---------------------------------------------------------------------------LAGRGPEKEDPVNLMKSIARNMFEG--FLDDL-ENNVLSRDDL--
G_gorilla_ENSGGOP00000011776              ---------------------------------------------------------------------------MADEKPSNGVPVHMVKLLIKTFLDG--IFDDLMENNVLNTDEI--
C_familiaris_ENSCAFP00000021904           ---------------------------------------------------------------------------VLTGKRQSQDPVNAIKVVASTMLNS--FLEDLKEKNVLNKQEL--
M_musculus_ENSMUSP00000027009             ---------------------------------------------------------------------------MAARRTHERDPIYKIKGLAKDMLDG--VFDDLVEKNVLNGDEL--
R_norvegicus_ENSRNOP00000029448           ---------------------------------------------------------------------------FTAKRTHERDPIYKIKGLAKDMLDG--VFDDLMDKNVLNGDEL--
P_pygmaeus_ENSPPYP00000004373             ----------------------------------------------------------------------------MAEGNHRKKPLKMLESLGKDFLTG--VLDNLVEQNVLNWKEE--
P_troglodytes_ENSPTRP00000041705          ----------------------------------------------------------------------------MAEGNHRKKPLKMLESLGKDFLTG--VLDNLVEQNVLNWKEE--
B_taurus_ENSBTAP00000027820               ----------------------------------------------------------------------------MAEDKHNKNPLKMLESLGKELISG--LLDDFVEKNVLKLEEE--
C_familiaris_ENSCAFP00000031565           -------------------------------------MYSSRQQHGLSLEHILKNGEIARDGKTYVVPIVEGVFVFLTEDKHDKNPFKILETVGKELITG--VLHGLLEKDILKLEDA--
H_sapiens_ENSP00000347741                 ----------------------------------------------------------------------------MAEGNHRKKPLKVLESLGKDFLTG--VLDNLVEQNVLNWKEE--
M_mulatta_ENSMMUP00000012893              ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000010831             ----------------------------------------------------------------------------MAEDRQERNLLKTLESVGKELITG--LSVGLVEKDVLKLKEE--
M_domestica_ENSMODP00000034020            ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000034022            ----------------------------------------------------------------------------LTDKVLMEKRRLFVESVDRGVMNG--LLDDLLEVQVLNLEEM--
M_mulatta_ENSMMUP00000012894              ------------------------------------------------------------------------------------------------MLHG--VFNHLAKHDVLTLNEE--
P_troglodytes_ENSPTRP00000007279          -------AVPRVEGVFIFLIEDSGKKKRRKNFEAMFKGILQSGLDNLVINHMLKNNVAGQTSIQTLVPNTDQKSTSVKKDNHKKKTVKMLEYLGKDVLHG--VFNYLAKHDVLTLKEE--
H_sapiens_ENSP00000376849                 -------AVPRVEGVFIFLIEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQTLVPNTDQKSTSVKKDNHKKKTVKMLEYLGKDVLHG--VFNYLAKHDVLTLKEE--
E_caballus_ENSECAP00000021890             -----------------------------------------------------------------------------TGNVLKEKRRLFIRSVGTGTVNS--LLDELLEKRVLNQEEM--
H_sapiens_ENSP00000260309                 ----------------------------------------------------------------------------MADKVLKEKRKLFIRSMGEGTING--LLDELLQTRVLNKEEM--
P_troglodytes_ENSPTRP00000059619          ----------------------------------------------------------------------------MADKFLKEKRKLFIRSMGEGTING--LLDELLQTRVLNQEEM--
P_pygmaeus_ENSPPYP00000004374             -------AVPIVEGVFIFLIEDSCKKKRRKNFEAVFKCILQSGLDNLVINHMLKNNVAGQTSIQTL-PNTDQKSTSVKKDNHKKKTIKMLEYLGKDVLHG--VFNHLAKHDVVTLKEE--
M_domestica_ENSMODP00000034033            ----------------------------------------------------------------------------LTDKVLKEKRRLFVESVDRGVING--LLDDLLELQVLNLEEM--
G_gorilla_ENSGGOP00000015374              -------------------------------------------------------------------------------DNHKKKTVKMLEYLGKDVLHG--VFNYLAKHDVLTLKEE--
P_pygmaeus_ENSPPYP00000004377             ----------------------------------------------------------------------------MADKVLKEKRKLFIRSMGEGTING--LLDELLQTRVLNKEET--
B_taurus_ENSBTAP00000027821               -----------------------------------------------------------------------------------EKRKLFVHSVSKGTING--LLDELLEKRVLNQEEM--
M_musculus_ENSMUSP00000027012             ----------------------------------------------------------------------------MAENKHPDKPLKVLEQLGKEVLTE--YLEKLVQSNVLKLKEE--
R_norvegicus_ENSRNOP00000009993           ----------------------------------------------------------------------------MADKILRAKRKQFINSVSVGTING--LLDELLEKRVLNQEEM--
M_musculus_ENSMUSP00000027015             ----------------------------------------------------------------------------MADKILRAKRKQFINSVSIGTING--LLDELLEKRVLNQEEM--
O_anatinus_ENSOANP00000016591             ----------------------------------------------------------------------------PPAQLLKDRWCLIIESLTHGMISG--LLDDLLQMQVINQEEM--
O_cuniculus_ENSOCUP00000000956            ----------------------------------------------------------------------------MADRILKDRRKRFINSVGTGTING--LLDELLEKRVLNQEEM--
R_norvegicus_ENSRNOP00000058685           ----------------------------------------------------------------------------LTENNHPDKPLKVLEELGKEFLTE--YLEKLVQSNVLKLKEE--
M_mulatta_ENSMMUP00000012901              -----------------------------------------------------------------------------TDKVLKEKRKLFIHSMGEASL----------------------
G_gallus_ENSGALP00000001569               ---------------------------------------------------------------------------------LLRVRADFVSRVRKAVVSN--LLDELLAHRVLNQAEV--
X_tropicalis_ENSXETP00000017024           -----------------------------------------------------------------------------LAAQLKKVRKLFIDGCNAAIINN--LLDDLLDKSVLTDSEV--
G_aculeatus_ENSGACP00000013201            ----------------------------------------------------------------------------YFSDKLKKVRTKFVEKASMSLIKQ--LLDDLLDNGILNDGQK--
A_carolinensis_ENSACAP00000013361         ------------------------------------------------------------------------------------------------------------------------
O_cuniculus_ENSOCUP00000006490            ----------------------------------------------------------------------------------YKDVLKEMESAGKAIAGS--FMDNLVKKKVIKLEKA--
D_rerio_ENSDARP00000034228                --------------------------------------------------------------------------------MAKSIKDHLQDALSNIGADN--LRRFQSRLGDRKQEPRVR
T_rubripes_ENSTRUP00000019853             ----------------------------------------------------------------------------LP-DQLASIRPMFVEKVSTQMINQ--LLDDIFMDGIVSEMEK--
T_rubripes_ENSTRUP00000035020             ----------------------------------------------------------------------------ME-DKLTSIRLMFVEKVSTQMINQ--LLDDIFMDGIVSEMEK--
O_latipes_ENSORLP00000007938              ---------------------------------------------------------------------------------------------------------MLLQDKVLNDEER--
T_rubripes_ENSTRUP00000013027             ----------------------------------------------------------------------------MAICQLDSIRLMFVEKVSTQMINQ--LLDDIFMDGIVSEMEK--
D_rerio_ENSDARP00000059407                --------------------------------------------------------------------------------KMEDITKLITDVLEELVESE--LKEFKRQLWMGVKKGV--
D_rerio_ENSDARP00000068268                ---------------------------------------------------------------------------------MEDITQLLSDVLEDLVESE--LKQFTRQLWIGVKPGV--
D_rerio_ENSDARP00000008601                -------------------------------------------------------------------------------------MTEEVNWDEDLEVDA--VVQNLNLYKTVMRNDKNS
C_elegans_C48D1.2                         ---------------------------------------------------------------------------MMRQDRRSLLERNIMMFSSHLKVDE--ILEVLIAKQ-VLNSDNGD
G_gallus_ENSGALP00000029853               ------------------------------------------------------------------------GACGMQRYHQEALKKNRVMLARELVLKE--LMEHMIEKD-IITIEMVE
A_carolinensis_ENSACAP00000006831         --------------------------------------------------------------------SRMLGVCGMQKCHQEALKKNRVSLAKQLVLKE--LMEHLIEKD-VITEEMME
D_rerio_ENSDARP00000075318                ----------------------------------------------------------------------------MADQLLENLRPDLIKGLSERVING--LLDDLQQKKVFGEEEI--
X_tropicalis_ENSXETP00000015203           ----------------------------------------------------------------------MLG--GMQKHHKDALQRLRVTLLHDMIIEE--LVEHLVSSG-ILTPIMHS
M_musculus_ENSMUSP00000031895             ---------------------------------------------MAAPSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQETLKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMRE
R_norvegicus_ENSRNOP00000022672           ---------------------------------------------MAASSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQETLKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMRE
E_caballus_ENSECAP00000003321             ---------------------------------------------MAAPSAPSLPALQQKGLMAADRGRRILGVCGMHPDHQEALKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMRE
B_taurus_ENSBTAP00000024166               ---------------------------------------------MAAPSAGFQYPLQPKEQMAADRGRRMLRGCGMHPDHQEALKKNRVVLAKELLLSE--LLEHLLEKD-IITLEMRE
O_anatinus_ENSOANP00000005545             ----------------------------------------------------------------------------MQPCHQEALKKNRVALAKQLMLSE--LLEHLLEKD-VITMEMRE
H_sapiens_ENSP00000312664                 ---------------------------------------------MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMRE
P_troglodytes_ENSPTRP00000033921          ---------------------------------------------MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMRE
P_pygmaeus_ENSPPYP00000017020             ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000016588              ---------------------------------------------------------------------RILGVCGMHPHHQETLKKNRVMLAKQLLLSE--LLEHLLEKD-IITLEMRE
O_anatinus_ENSOANP00000000517             ------------------------------------------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000037606             --------------------------------------------------------------------RSKMLHCGMREQDARTLRRQSAVLCKQLVVDE--LLIQCLQADDILTESMAE
C_familiaris_ENSCAFP00000005409           ---------------------------------------------MAAASAGRPAALQRKAPTAAGRGRRILGVCGMHPDHQEALKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMRE
E_caballus_ENSECAP00000019797             ------------------------------------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000013612              ----------------------------------------------------------------------MLAACGMQRCHQEALKKNRVMLAKQLVLNV--LVEHMVEKD-IIPTEMVE
P_troglodytes_ENSPTRP00000054330          ------------------------------------------------------------------------------------------------------------------------
H_sapiens_ENSP00000311032                 ------------------------------------------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000020323             ---------------------------------------------MAAPTAGSWSTFEHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMRE
E_caballus_ENSECAP00000010379             ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000015808              ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000015114              --------------------------------------------------------------------RSVTQKCGMQKRDAEALRNCSVCLLKDLVVDE--LLIQALVKDGILTQNMAE
G_aculeatus_ENSGACP00000013740            --------------------------------------------------------------------------CGMQERDRLALRTRSTVLCKQLVVDE--LLIQSLQTDEILTEAMAE
O_cuniculus_ENSOCUP00000001859            ---------------------------------------------MAAPSAGSRASLQQKGLLAADRGRRITAVCGMHPDHQETLKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMRE
M_domestica_ENSMODP00000001598            ---------------------------------------------------------------------RMLGVWGMEQEHQEALKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMRE
T_nigroviridis_ENSTNIP00000009934         -----------------------------------------------------------------------------------------------------------------------M
T_rubripes_ENSTRUP00000040691             ---------------------------------------------------------------------------------------------------------------------TNM
T_nigroviridis_ENSTNIP00000010874         -----------------------------------------------------------------------MLQCGMVERDAQALKKQSAVLFKQLVVDE--LLIQFLQADDILTDSMAE
T_guttata_ENSTGUP00000006879              ---------------------------------------------------------------------------------------------------------------------MTD
D_rerio_ENSDARP00000083664                ----------------------------------------------------------------------MLGECGMTKWERLALRRNSVKMLQDLVVDD--LLIQCLQQDGILTDSMAE
G_aculeatus_ENSGACP00000024809            ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000004412            ----------------------------------------------------------------------------MEESQRELFQKNRLRLVCELQVEP--LWDLMLDRE-LFTRDMIE
G_gallus_ENSGALP00000017288               --------------------------------------------------------------------------------------------------------------------MMTD
E_caballus_ENSECAP00000015102             ----------------------------------------------------------------------------MNEADRQLLRRSRLRLVRELQVDS--LWDALLTRE-LFTPDMIE
E_caballus_ENSECAP00000013731             -------------------------------------------------------------------------------------------------------------MA-DDQDCVVE
C_familiaris_ENSCAFP00000032189           ------------------------------------------------------------------------------------------------MGEQRNTSSKELAAAEATGQSGKE
C_familiaris_ENSCAFP00000023821           ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000014096           ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000005556            ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000024812            ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000010095              ------------------------------------------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000002138             ----------------------------------------------------------------------------MDEADRRLLWRCRLRLVEELQVDQ--LWDALLSRE-LFRPHMIE
G_aculeatus_ENSGACP00000024816            ------------------------------------------------------------------------------------------------------------------------
O_cuniculus_ENSOCUP00000002346            ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000022402            ------------------------------------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000017449              ----------------------------------------------------------------------------MEERQRRALRRGRARLVAALRVEP--LWEPLEQRG-LFTRPMLE
R_norvegicus_ENSRNOP00000017972           ----------------------------------------------------------------------------MEEADRQLLRRCRVRLVRELQVAE--LWDALLSRE-LFTRDMIE
B_taurus_ENSBTAP00000028116               ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000002083               ----------------------------------------------------------------------------MEEAQRSALRRGRVRLVEGLRPEV--LWGPLQARG-VFTSAMVE
M_musculus_ENSMUSP00000030747             ----------------------------------------------------------------------------MDEADRQLLRRCRVRLVSELQVAE--LWDALLSRE-LFTRDMIE
M_musculus_ENSMUSP00000091238             ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000035938           ------------------------------------------------------------------------------------------------------------------------
O_anatinus_ENSOANP00000015596             ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000003205               ----------------------------------------------------------------------------MNEADRLLLRRYRVRLVGELQVAS--LWDALLSRE-LFTPDMIE
C_intestinalis_ENSCINP00000002956         ---------------------------------------------------------------------------AMKKRHRNTLIKNRVKLAKCLHLDE--VLQYLVQCG-ILTDVTVE
T_nigroviridis_ENSTNIP00000022078         ----------------------------------------------------------------------------------------------------------MAGEA-AGIPELGG
G_aculeatus_ENSGACP00000005791            -----------------MHFQKLLFDIGKALSGEEVKALAFLCTDILG--RNLSSVESASGLFSRLRDQGFLSAEQPHLLTELLIIIQRVRLTRDVDLPA--EPSSLISP--------YR
B_taurus_ENSBTAP00000021099               ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000056642          -----------------------------------------RGGRPWGGGGSWGLGRAAEARKRTEAAWSLSWLLAMDEADRRLLRRCRLRLVEELQVDQ--LWDALLSRE-LFRPHMIE
D_rerio_ENSDARP00000006831                ------------------------------------------------------------------------------------------------------------------------
H_sapiens_ENSP00000221740                 ------------------------------------------------------------------------------------------------------------------------
D_rerio_ENSDARP00000071815                ------------------------------------------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000031759             -------------------------------------------------------------------------------------------------------SMQMAGEP-TEISDLGG
M_mulatta_ENSMMUP00000040583              ----------------------------------------------------------------------------MDEADRRLLRRCRLRLVEELQVDQ--LWDALLSRE-LFKPHMIE
H_sapiens_ENSP00000365051                 -----------------------------------------RGGRPWGGGGSWGLGRAAEARKRTEAAWSLSWLLAMDEADRRLLRRCRLRLVEELQVDQ--LWDALLSRE-LFRPHMIE
C_familiaris_ENSCAFP00000023986           ----------------------------------------------------------------------------MDEAERRALRRCRVRLVRELQVAA--LWDALLSRE-LFTAAMVE
M_mulatta_ENSMMUP00000024183              ------------------------------------------------------------------------------------------------------------------------
C_familiaris_ENSCAFP00000007585           --------------------------------------------------------MERSPGSGGRWECSGPPAPPELTPDVAELQSRVQETLELLSPQD--LRNFRLLLKTVDEEPRVS
G_aculeatus_ENSGACP00000008661            -------------------------------------------------------------------------------------------------------QVNGA-RL-TSAQDVA-
M_domestica_ENSMODP00000018104            ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000005560            ------------------------------------------------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000024485         ------------------EFRLLLHQICEGLTGENVSMMKFLCKDAIPRSRELETALDFMEYFEAKGWIQEGDLGFLAEVLYRINRHDLLKLLPGVKNRR--DYEENFQAQ-QNNFTTYR
C_familiaris_ENSCAFP00000016420           -------------------------------------------------------------------------------------------------------------MA-DDQDCGME
G_gallus_ENSGALP00000014503               ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000009643           ------------------------------------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000011206              ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000010793              --------------------------------------------------------------------------------------------------------------------MDMA
X_tropicalis_ENSXETP00000003217           ---------------------------------------------------------------------------------------------------------------------MEE
D_rerio_ENSDARP00000063081                ---------------------------------------------------------------------------MSKKESTQRILQHKVFLIDTLSVEASFILQNVQQAKLITQRDY--
D_rerio_ENSDARP00000075650                ---------------------------------------------------------------------------MDKKESVDKICENKIFLLETLSVDANFILQHVQQAKLITLRDY--
A_carolinensis_ENSACAP00000002670         ------------------------------------------------------------------------------------------------------------------------
A_carolinensis_ENSACAP00000009923         ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000023055            ------------------------------------------------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000007986         ----------------------------------------------------------------------------MLSTHKEKLRTNRHTLCKELVVDE--LLQELIGEG-IFNDILAD
T_guttata_ENSTGUP00000004278              ------------------------------------------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000044662             ---------------CNMDFQARLLKVGNDLRKDEVRALVFLCSDILG--CNPAAVQSAGDLFSRLSDQDHLSEEQPHLLVELLGIIQRTKLLRDHNLPR--TGAQDLISP-YSCKS--R
A_gambiae_AGAP004920-PA                   -----------------------------------------------------------------------------------------------------------VCGRDILHCKTMN
D_rerio_ENSDARP00000019984                -----------------------------------------------------------------MDKEALTSENEVSGDDQENYGKGDVTDAKPDPKAM--CRVDKE-AL-TSEIEVLE
M_domestica_ENSMODP00000032734            ----------------------------------------------------------------------------MLQPDMESFKAQVVSTLTKLSPEE--LRRFGIYLRNVGEEPRVS
B_taurus_ENSBTAP00000012869               --------------------------------------------------------MEGSLGSGRRSGSDGQPAPPKISPTTEELQSRLQETLDLLSSQE--LRSFRDHLKKV--EPPVS
E_caballus_ENSECAP00000021726             MTSQGQNLNSSSDDNCTMDFRQKLLFIDSHLGDQDVERLRFLCRDCVSH-KKLEKSSSALEIFNHLLAEDLLREEDSFFLAELLYIIKQKSLLCHLCYTK--EQVESLLPA-RRRVSLFR
B_taurus_ENSBTAP00000008706               ------------------------------------------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000026062             -------------------------------------------------------------------------------------------------------------MT-DDQDCAAE
D_rerio_ENSDARP00000024255                ------------------------------------------------------------------------------------------------------------------------
A_carolinensis_ENSACAP00000013788         ------------------------------------------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000005488             ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000022693           -------------------------------------------------------------------------------------------------------------MT-DDQDCAAE
A_gambiae_AGAP011949-PA                   ------------------------------------------------------------------------------------------------------------------------

                                                  130       140       150       160       170       180       190       200       210       220       230       240
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000364878                 HLIGKCLKFVVSNAENLVDDITETAQTAGKIFREHLWNSK-----KQLSS----------------------------------------------------------------------
P_troglodytes_ENSPTRP00000047678          HLIGKCLKFVVSNAENLVDDITETAQIAGKIFREHLWNSK-----KQLSS----------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000004372             HLIGTCLKFVVSNAENLVDDITQTAQIAGKIFREHLWNSK-----KQLSS----------------------------------------------------------------------
M_mulatta_ENSMMUP00000021744              ------------------------------------------------------------------------------------------------------------L-----------
E_caballus_ENSECAP00000006810             RKLGKRVNRIVNGTENLVEDLSEKTEVAGKIFLKHLLKPK-----KQMNLKS-------LADYEDDESE-DT-----ESPFSSTESACEGEDEETEENAGLSQASVPPM-----------
G_gorilla_ENSGGOP00000011776              HLIGKCLKFVLSNAENLVDDITETAQIAGKIFREHLWNSK-----KQLSS----------------------------------------------------------------------
C_familiaris_ENSCAFP00000021904           QTMGQTVNVITKKTENLVGDLTEKTQVVGKIFKDHFLNSG-----SLLSLSW-------SSTSATKPSGSCR-----PSYLTQARSRKKEEVPKILVFVIFLYKMVFL------------
M_musculus_ENSMUSP00000027009             LKIGESASFILNKAENLVENFLEKTDMAGKIFAGHIANSQ-----EQLS-LQ-------FSNDEDDGPQ-KI-----CTPSSPSESKRKVEDDEMEVNAGLAHESHLML-----------
R_norvegicus_ENSRNOP00000029448           LKIGEGASLILSKAENLVESFFEKTEMAGKIFAGHIANSD-----KQLSLLQ-------ADRNQITGPSFQI-----LVFNSLSESRGKVEDEEMEVNVGVAHASHLML-----------
P_pygmaeus_ENSPPYP00000004373             EKKKYYDAKTEDKVRVMADSIQEKQRMAGQMLLQTFFNID-----QISPNKK-------AHPN---------------------------------------------------------
P_troglodytes_ENSPTRP00000041705          EKKKYYDAKTEDKVRVMADSIQEKQRMAGQMLLQTFFNID-----QISPNKK-------AHPN---------------------------------------------------------
B_taurus_ENSBTAP00000027820               EKKKIYDAKLQDKARVLVDSIRQKNQEAGQVFVQTFLNID-----KNSTSIK-------APEE---------------------------------------------------------
C_familiaris_ENSCAFP00000031565           EKKTFYDAKPEDKPWVILNSVRQKRQEAGQALVHTFINTD-----KYSTSVE-------AFVE---------------------------------------------------------
H_sapiens_ENSP00000347741                 EKKKYYDAKTEDKVRVMADSMQEKQRMAGQMLLQTFFNID-----QISPNKK-------AHPN---------------------------------------------------------
M_mulatta_ENSMMUP00000012893              ----------------MADSIQEKQRMAGQMLLQTFFNID-----QISPSKK-------AHLN---------------------------------------------------------
E_caballus_ENSECAP00000010831             ERKKFYEAKPGDKPWVLVDSVRDRRHEAGQILWQALFNID-----RSVISRK-------ALEE---------------------------------------------------------
M_domestica_ENSMODP00000034020            ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000034022            EIVREESKTNRDKARVLIDAVISKGPKASQCFTKSICERD-----GHLAEKL-------GLSSELNSNQSHI-----SLCREQAPRPINICILRNDN-----------------------
M_mulatta_ENSMMUP00000012894              EKENYYNVKIEDKALILVDSVR-KNRVAHQRFTQTLLNMD-----QRITSVK-------SLLQ---------------------------------------------------------
P_troglodytes_ENSPTRP00000007279          EKKKYYDAKIEDKALILVDSLR-KNRVAHQMFTQTLLNMD-----QKITSVK-------PLLQ---------------------------------------------------------
H_sapiens_ENSP00000376849                 EKKKYYDTKIEDKALILVDSLR-KNRVAHQMFTQTLLNMD-----QKITSVK-------PLLQ---------------------------------------------------------
E_caballus_ENSECAP00000021890             EKVRDENATVMDKARALIDAVIRKGPQACQIFIGHICEDD-----PHLAETL-------RLSSGPQSGNFLK-----TQDSQAVVHSSPALQAMP-------------------------
H_sapiens_ENSP00000260309                 EKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEED-----SYLAGTL-------GLSADQTSGNYLN-----MQDSQGVLSSFPAPQAVQ-------------------------
P_troglodytes_ENSPTRP00000059619          EKVKRENATAMDKTRALIDSVIPKGAQACQICITYICEED-----NYLAGTL-------GLSADQTSGNYLN-----MQDSQGVLSSFPAPQAVQ-------------------------
P_pygmaeus_ENSPPYP00000004374             EKKKYYNAKIEDKALILVDSVR-KNRVAHQIFIQTLLDMD-----QKITSVK-------PLLQ---------------------------------------------------------
M_domestica_ENSMODP00000034033            EILKEESRTIRDKARVLIDAIISKGPKASQCFTKSIWERD-----GHLAEKL-------GLSSGKRKYL--------LGKADHSIHGEKLKTKQRHT-----------------------
G_gorilla_ENSGGOP00000015374              EKKKYYDAKIEDKALILVDSXR-KKRVAHQMFTQTLLNMD-----QKITSVK-------PLLQ---------------------------------------------------------
P_pygmaeus_ENSPPYP00000004377             EKVKRENATVMDKTRALLDSLIPKGARACEICITYICEED-----SYLAETL-------GLSADQTSGNYLN-----MQDSQGVLSSFPAPQAVQ-------------------------
B_taurus_ENSBTAP00000027821               EKIRDENDTAMDRARVLIDTVIRKGPQACQICISHICEED-----SHLAGIL-------GLTSGSQSENYLR------QKPQAVVPPFPAPQAML-------------------------
M_musculus_ENSMUSP00000027012             DKQKFNNAERSDKRWVFVDAMKKKHSKVGEMLLQTFFSVD-----PGSHHGE--------------------------------------------------------------------
R_norvegicus_ENSRNOP00000009993           DTIKLANITVMEKARDLCDHVTKKGPRASQMFITYICNED-----CYLAEIL-------ELQSGPSAETVFV-----TEDSKG-GHPFSSETKEK-------------------------
M_musculus_ENSMUSP00000027015             DKIKLANITAMDKARDLCDHVSKKGPQASQIFITYICNED-----CYLAGIL-------ELQSAPSAETFVA-----TEDSKG-GHPSSSETKEE-------------------------
O_anatinus_ENSOANP00000016591             DTVREEHHRPAEKTRALLNSVIPKGDLASQIFIDSLCKKN-----PFVAAKL-------GLSAGGQGQSGNTQFVGQSQMIPAVATSCSVPQALQAP-----------------------
O_cuniculus_ENSOCUP00000000956            EKVRVENATVMDKARALLDCVIRKGPQACQICINHICEDD-----CHLAGLL-------GLSSGPQSENHFN-----AQDSLEAFSSFSAPQTTQ-------------------------
R_norvegicus_ENSRNOP00000058685           EKQKFNNAERSDKRWVFVDVLKRKHNQVGKMLLQTFLNVD-----SGSHHGE--------------------------------------------------------------------
M_mulatta_ENSMMUP00000012901              --------------------------------------------------------------------------------------------AMQ-------------------------
G_gallus_ENSGALP00000001569               DEVQEGNPVTTDKARSLIDTVRLKGPRASAIFIDSLRKHD-----CNLAEQL-------RLCAHAEPPGAPLAAPSTVGFSDP-------------------------------------
X_tropicalis_ENSXETP00000017024           EYINECNAITKDRCRRMIDNIKNKGDYSSNILLQCLVENH-----KTLAKNM-------GLD-----------------VSEPAIAPQPIQ-----------------------------
G_aculeatus_ENSGACP00000013201            DSILEENGTKADRARNLIDVVKAKGNKASEILIASLESRD-----SSLFSEL-------GLS-----------------SAQTAPPAISGVSNIFKL-----------------------
A_carolinensis_ENSACAP00000013361         ------------------------------------------------------------------------------------------------------------------------
O_cuniculus_ENSOCUP00000006490            KREKFYDAKTHKKAQILVDSLREKCHEEDQKLTETFLNID-----QNSTGMQ-------XXXX---------------------------------------------------------
D_rerio_ENSDARP00000034228                KSTIEKLKDEIDLVDLLVNTFTSDAVSVTVDILRGIKCNAVA---EELLENT-------GQVYSIF----------KLCKKNSHYTKPPIIITDVFMFCFLGGVSQPEPPVP--------
T_rubripes_ENSTRUP00000019853             ESITEESNIRSDKARRLIDSVRKKGERACKKMISHIQSRD-----PELSAVL-------GLS-----------------CGHPAPP--------GELRDDTLFQTDRIVSFRF-------
T_rubripes_ENSTRUP00000035020             ESITEESNIRSDKARRLIDSVRKKGERACKKMISHIQSRD-----PELSAVL-------GLS-----------------CGHPAPPVFNRRAPDGRSR-------VIFNSPINRC-----
O_latipes_ENSORLP00000007938              ESICEEKS-RADMARSLIDTVRKKGSTASKMMINHFEQKD-----PILFSEL-------GLS-----------------CPEPAQT----------------------------------
T_rubripes_ENSTRUP00000013027             ESITEESNIRSDKARRLIDLVRKKGERACKKMISHIQSRD-----PELSAVL-------GLS-----------------CGHPAPP--------GELR-------GQLESPAF-------
D_rerio_ENSDARP00000059407                EAIPRGKLENKDRQDVVDYMVQHYSMDAGKIAVQALRSIKQNERANRLESKL-------LEAVSSS----------DLFQPQAQENEQNPEDPQSIN-----------------------
D_rerio_ENSDARP00000068268                EPIPRGKLENKDRQDVVDSMVQQYSEDAGTITVQTLRKIKQNERAKRLESNL-------LKV-----------------QSQGQENKQNSEEPQPIPQIISQPIQQIISQPINNAGSE--
D_rerio_ENSDARP00000008601                NSEVQLSNELVDFAVELTCGHRMPVDYVVAWFKCYLKQKETDFSCPHFIVDQ-------GKTCGAK----------LSYQEICQLIPLSDKQREFLEENLAAIVARRLFDFKSCPGCQSH
C_elegans_C48D1.2                         MINS--CGTVREKRREIVKAVQRRGDVAFDAFYDALRSTGHEGLAEV-LEPL-------ARSVDSN----------AVEFECPMSPASHRRSRALSPAGYTSPTRVHRDSVSSVSSFTSY
G_gallus_ENSGALP00000029853               MIQA--KSGSFSQNVEFLNLLPKRGPNAFSAFCEALQETKQQHLAEMILKTE-------SS--LRH----------G----IAT-----------------LEQR----YGSNLPLP-LS
A_carolinensis_ENSACAP00000006831         MIQA--KAGNFSQNIEFLNLLPKRGPKAFSAFCEALRETKQPHLEEMLLLNL-------IDFLLFH----------HVI--VPP-------------------------QNAHLPLHTVC
D_rerio_ENSDARP00000075318                EDIQHRMKTRADQARHVIDDVKRKGVKASEIMLASLKTRDPHLYDTLGIERL-------LVPVPET----------ELTPSQLSETTGCST-----------------------------
X_tropicalis_ENSXETP00000015203           TIMA--HRSEYKQNVTLLTQLPKRGPRAFSEFCNALHATGQRHLAEQLEEEA-------QQQQMES----------V----TPE--------------------V----HERSFPLP-VQ
M_musculus_ENSMUSP00000031895             LIQA--KGGSFSQNVELLNLLPKRGPQAFDAFCEALRETRQGHLEDLLLTTL-------SD--IQH----------V----LPP-----------------LSCD----YDTSLPFS-VC
R_norvegicus_ENSRNOP00000022672           LIQA--KGGSFSQNVELLNLLPKRGPQAFDAFCEALRETRQGHLEDLLLTTL-------SD--IQH----------I----LPP-----------------LSCD----YDSSLPFS-VC
E_caballus_ENSECAP00000003321             LIQA--KVTSFGQNVELLNLLPKRGPQAFEAFCVALRETKQGHLEDLLLTTL-------SG--LQH----------V----LPP-----------------LSCD----YDLSLPFP-VC
B_taurus_ENSBTAP00000024166               HIQA--KTGSFGQNVELLNLLPKRGPQAFDAFCVALRETKQSHLEELLLRTL-------SG--LQP----------V----VPP-----------------LSCD----YDLSLPFP-VC
O_anatinus_ENSOANP00000005545             LIQA--KAGSFSQNVEFLNLLPKRGPKAFDAFCAALRETKQGHLQDLLYRTL-------SN--LS-----------------PPSTAVGALGTQGEELAGRLGGR----WRGLPSLP-SV
H_sapiens_ENSP00000312664                 LIQA--KVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLTTL-------SG--LQH----------V----LPP-----------------LSCD----YDLSLPFP-VC
P_troglodytes_ENSPTRP00000033921          LIQA--KVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLTTL-------SG--LQH----------V----LPP-----------------LSCD----YDLSLPFP-VC
P_pygmaeus_ENSPPYP00000017020             ----MENTENSVDSKS----IKNLE---PKVIHGSKSMDS--------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000016588              LIQA--KVGSFSQNVELLNLLPKR-PQAFDAFCEALRETKQGHLEDIELKLR-------VS--ALM----------K----PTG-----------------LGSD----YNDILGLM-VK
O_anatinus_ENSOANP00000000517             ----AASGEVMVDSKS----FHSSQGYSSRKVPGKQFLGS--------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000037606             SIMA--EQTSQKRSWRLQLLLPKRGPKAFSSFCSALRATDQQHLCDLLTQTF-------ET--NGN------------------------------------GTHVETCVDSSVPLP-TQ
C_familiaris_ENSCAFP00000005409           HIQA--KVGGFSQNVELLNLLPKRGPQAFDAFCVALRETKQGHLEDLLLTTL-------SG--LQH----------G----LPP-----------------LSCD----YDLSLTFP-MC
E_caballus_ENSECAP00000019797             ----MENSKISVDSKS----IKNSE---TKILHGSKSMDS--------------------------------------------------------------------------------
T_guttata_ENSTGUP00000013612              MIQA--KSGSFDRNVEFLNLLPKRGPNAFSAFCEALRETQQQHLETLILKTM-------SS--LSQ----------E----IAR-----------------LEHC----HESDLPYP-AS
P_troglodytes_ENSPTRP00000054330          ----MENTENSVDSKS----IKNLE---PKIIHGSQSMDS--------------------------------------------------------------------------------
H_sapiens_ENSP00000311032                 ----MENTENSVDSKS----IKNLE---PKIIHGSESMDS--------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000020323             LIQA--KVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLTTL-------SG--LQH----------V----LPP-----------------LSCD----YDLSLPFP-VC
E_caballus_ENSECAP00000010379             ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000015808              ----MENTENSVDSKS----IKSLE---PKIIHGSKSVDS--------------------------------------------------------------------------------
O_latipes_ENSORLP00000015114              SIMV--QKTSHHRSFKLLLLLPKRGPRAFKSFCSALKETEQEHLCDLLTQ---------EE--EGR----------EVCLDTPL-----------------INSEEQSEVSSSMSYP-IH
G_aculeatus_ENSGACP00000013740            NIMA--EQTSQKRSWRLLLLLPKRGPRAFSSFCSALQETEQQHLYELLIQSS-------EK--DGK----------E----TPG-----------------MLMCGQF-IDSSLPLP-TQ
O_cuniculus_ENSOCUP00000001859            LIQA--RVGSFSQNVELLNLLPKRGPQAFDAFCVALRETKQGHLEDLLLTTL-------SG--LQH----------V----LPP-----------------LSCD----YDLSLPFP-VC
M_domestica_ENSMODP00000001598            LIQA--KVGSFSQNVEFLNLLPKRGPHAFEAFCDALRETKQGHLEDLLHRTL-------YS--FQN----------L----RPP-----------------LGCD----YDSSFPLP-VC
T_nigroviridis_ENSTNIP00000009934         SANGPASGEDFTDASK---GGEQPSGSSSS---GKMTVDA--------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000040691             SANGPSPGGDFTDAKK--GAGQQPRSGSSS---GRVTVDA--------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000010874         SILA--EQTSHKRCWKLLHLLPKRGPKAFSSFCSALRETDQKHLCDLLARTS-------QE--NGN------------------------------------GTHLETCVDSSVPLP-TQ
T_guttata_ENSTGUP00000006879              IGDGAHLGKDLADTKS----IPGFK---GKNLPASKSMDS--------------------------------------------------------------------------------
D_rerio_ENSDARP00000083664                SIMA--KPTSQGRSHQLLFLLPKRGPRAFSTFCSALKETEQHHLCKLLMDFT-------EK--DKK----------N----SQY-----------------KL---------------SP
G_aculeatus_ENSGACP00000024809            --------------------------------MDKLYRDV--------------------------------------------------------------------------------
M_domestica_ENSMODP00000004412            DIQR--AGTRRDQARQLVTDLQTRGKRALPIFISCLEATGQWDLAALLSESN-------TTLTQQP----------DPIDIKPVEMIRSGGLRSTGRYTSMVSLH-------LLLLANSP
G_gallus_ENSGALP00000017288               IKDGPRSGEDVSDARS----FPGSK---GMNLPASKSVDS--------------------------------------------------------------------------------
E_caballus_ENSECAP00000015102             DIQR--SGSRRDQARQLIIDLETRGSQALLLFISCLEDTGQDTLASFLRTSS-------QAAKQNP------------EAIRPSD-LPPVVLGPVGLKPEELTAV--------KQDPSKL
E_caballus_ENSECAP00000013731             QGAGDSTSTDAVDAKP----DRSSFVPSLFS-KKKKNGPE--------RSIT--------TN----------------------------------------------------------
C_familiaris_ENSCAFP00000032189           LEVSMENTENSVDAKS----FKNAE---TVIV---KILKD--------------------------------------------------------------------------------
C_familiaris_ENSCAFP00000023821           ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000014096           ----MDNNETSVDSKS----INNFE---TKTIHGSKSMDS--------------------------------------------------------------------------------
M_domestica_ENSMODP00000005556            ----MEDTGTTVDAKS----TKNSG---VKLFHGSKSVES--------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000024812            ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000010095              -MASNRPGEDSTDARK----DNGELAAGASPAPDRMDVDG--------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000002138             DIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNR-------QAAKL-----------------------------------------------------SKP
G_aculeatus_ENSGACP00000024816            ------------------------------------------------------------------------------------------------------------------------
O_cuniculus_ENSOCUP00000002346            ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000022402            -MSVNGPGEDRTDAKT----EQSEVSSSAS---APEEVDA--------------------------------------------------------------------------------
T_guttata_ENSTGUP00000017449              ELQS--AGSRGEQARQLIIDLETRGKQAFPAFLSILRDTGQGHLAEMLMQEC-------ESRPVPP----------QLPDLRPVEL----------------------------------
R_norvegicus_ENSRNOP00000017972           DIQRAGSGSRRDQARQLVIDLETRGRQALPRFISCLEDTGQGSLASFLQSSG-------QAAKQDP------------EAVTPLDHLVPVVLGPMGLKSKEQKVV--------KLDPSQP
B_taurus_ENSBTAP00000028116               ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000002083               DMQS--TGTRREQARQLVIDLETRGKQAFPIFLSILRDTGHGDLADMLDEGC-------GSPMSPP------------VDLRPVQLELPGERRD--------------------------
M_musculus_ENSMUSP00000030747             DIQQAGSGSRRDQARQLVTDLETRGRQALPLFISCLEDTGQGTLASLLQSGR-------QAAKQDP------------EAVKPLDHLVPVVLGPMGLTAKEQRVV--------KLDPSQP
M_musculus_ENSMUSP00000091238             ----MENNKTSVDSKS----INNFE---VKTIHGSKSVDS--------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000035938           -------------------------------STKKKKTEDPE---KPPQASD--------NV----------------------------------------------------------
O_anatinus_ENSOANP00000015596             ------AGTRRDQARQLVTDLETRGRRALSVFISCLRETDQHALAALLSEGC-------QAPQVTP------------VDIRPVEIIRPGGQGDVCKYSKIHPKC------------YSP
B_taurus_ENSBTAP00000003205               DIQRAGSGSRRDQARQLILDLETRGSQALPLFISCLEDTGQDTLASLLKTSR-------QAAKQ-----------------------------------------------------SKP
C_intestinalis_ENSCINP00000002956         RITS--KPTRFSQNVAFLTCLPTRGPRAYGTFLEALRISSQEHLVDILEKVD--------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000022078         EAEGEHRCEDDVDAKP----DRRGRFLLFKS-KKKNDGQMRE---QDYCSES--------HY----------------------------------------------------------
G_aculeatus_ENSGACP00000005791            KMLYNLSEELTADDLKDMKFLLHSYLPRRKLEENVSTLEIWL---EMEHKDL-------MNEHNLH----------LLEILISKVCPMLKDKINQLKAQQETPTSPATQESGRQGSLSA-
B_taurus_ENSBTAP00000021099               ----MENTENSVDSKS----IKTSE---TKILHGSKSMDS--------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000056642          DIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNR-------QAAKL-----------------------------------------------------SKP
D_rerio_ENSDARP00000006831                ------MNGDCVDAKRVDTTDASKDGASAS---QPMQVDA--------------------------------------------------------------------------------
H_sapiens_ENSP00000221740                 ------------------------------------------------------------------------------------------------------------------------
D_rerio_ENSDARP00000071815                MSDVKPKGVDTVDARQ----SDAKESSSVTD-PGLVQMDA--------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000031759             EVEEGGQSEDDVDAKP----DRKGRFLLFKS-KKNKDGQMRE---QDYCSES--------HY----------------------------------------------------------
M_mulatta_ENSMMUP00000040583              DIQRAGSGSRRDQARQLITDLETRGSQALPSFISCLVDTGQDMLASFLRTNR-------QAVKL-----------------------------------------------------SKP
H_sapiens_ENSP00000365051                 DIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNR-------QAAKL-----------------------------------------------------SKP
C_familiaris_ENSCAFP00000023986           DLQHAGSGSRSDQARQLVIDLETRGSQALPLFISCLEDTGQDALASCLTMSR-------QAVKQNP------------EATRPLD-LMPVVLGPTRLTPEDLR----------GKDPSKL
M_mulatta_ENSMMUP00000024183              ------------------------------------------------------------------------------------------------------------------------
C_familiaris_ENSCAFP00000007585           PVKLELEGRKKAGLARLVAQNYCEPA-ASRVLVKVLRQLRRADLLRLW--QG-------AADRGGE----------RIPRKILK------------------------------------
G_aculeatus_ENSGACP00000008661            -AEEGGPTGDQTDAKP----DRRGRFLLFGNIKKNKDGQTRE---QDYSSES--------HY----------------------------------------------------------
M_domestica_ENSMODP00000018104            ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000005560            ----MEDTGTTVDAKS----IKNSG---VKSLHSSKSVES--------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000024485         VVCFMLADELTEGDLKILKRLCAGKMSKANVRRSVDVLSWLT---CMEEEDL-------LSEGDLD----------FIMSILQHLDNQKPYKLFQRVRMNDNTVTLPKNQQKSNAFQPNS
C_familiaris_ENSCAFP00000016420           QAAGDSESPDAVDARP----DRSSFVPSLFS-RKKKNDSG--------RSIK--------TA----------------------------------------------------------
G_gallus_ENSGALP00000014503               ---------------------------------KKKNGEEEQ---PKSSLSN--------QY----------------------------------------------------------
R_norvegicus_ENSRNOP00000009643           ------------------------------------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000011206              ---------------------------------KKKNGEEEQ---PKPSLSN--------QY----------------------------------------------------------
O_latipes_ENSORLP00000010793              ETAEELSGKDQVDTKP----VISKRSPANQ--PNPRSTDV--------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000003217           SHNGVQYGEDTADAKT----YFTNQQISLQNCDIKDMEKK--------------------------------------------------------------------------------
D_rerio_ENSDARP00000063081                -NNLSDVSERETKIIKLLDKLIGRGEETCQEFIDLLRQDCVLENFPVLEGHA-------IFA----------------------------------------------------------
D_rerio_ENSDARP00000075650                -NNLSDFPQRETKIINLLDKLMGKGEETCHQFIALLRQDCVLENFPMLKDHD-------IFD----------------------------------------------------------
A_carolinensis_ENSACAP00000002670         -------------------------------IPVSKSVDS--------------------------------------------------------------------------------
A_carolinensis_ENSACAP00000009923         ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000023055            ------MSDTTGDGRGGRVASPNKAATDRAACTENLTETD--------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000007986         RVLS--HQRDFKKNVEFLTLLPGRGPNAFNAFRIALINSDQSHLAELLDPAQGVSQPNESNANDGSGGPELSASIFRFESIATANSNLPGTSGTSAPLSRRRPMENTDQSSTSIASSQVI
T_guttata_ENSTGUP00000004278              ------MSGSERRPPAGHVQLDSRPTLPTTDGNENITEVDA-------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000044662             KLLYSLSEELTADDLKDIKFLLNNKLPRGKLEE-VTTLEVFM---ELEHRAL-------ISDTDLG----------FLESIIQPVCPVLLEKINQFNA----------QNCKMHLILHIF
A_gambiae_AGAP004920-PA                   TSTLSTAFDEVDNNTRVLSLVASVPEIISSSVIHELEPV---------------------------------------------------------------------------------
D_rerio_ENSDARP00000019984                EDQDSYGEEDVTDAKP----DRKGRFRLFGN-FKKNDGKLQE---KG-ESES--------HY----------------------------------------------------------
M_domestica_ENSMODP00000032734            RHDLEM-ATKPEELADLLLKRYVMTG-TPRVLVQVLGQVPRKDLALEWALRR-------RSPSRCK----------SMSRMNLK------------------------------------
B_taurus_ENSBTAP00000012869               QVKLELEGHSPSGLAKLLAKHYYPAAVAKRVLVQVLELLPRADLLPRW---Q-------SAPTDCP----------VIPRKSLK------------------------------------
E_caballus_ENSECAP00000021726             NLLYELSEGMDSDNLNSMMFLLKDSIPKTQ----MTSLSLLA---HLEKQAR-------IDEDNLT----------LLEMLCKNVVPNLMRKIEKYKR----------EKAAQVVTAPVD
B_taurus_ENSBTAP00000008706               ------------------------------S-KKKKNDSG--------KSVN--------IP----------------------------------------------------------
M_musculus_ENSMUSP00000026062             LEKVDSSSEDGVDAKP----DRSSIISSILL-KKKRNASA--------GPVR--------TG----------------------------------------------------------
D_rerio_ENSDARP00000024255                ------------------------------------------------------------------------------------------------------------------------
A_carolinensis_ENSACAP00000013788         ------------------------------------------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000005488             ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000022693           LEMADSSTEDGVDAKP----DRSTIISSLLW-KKKKNASM--------CPVS--------TT----------------------------------------------------------
A_gambiae_AGAP011949-PA                   ------------------------------------------------------------------------------------------------------------------------

                                                  250       260       270       280       290       300       310       320       330       340       350       360
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000364878                 --------------------------------------------------------------------------------------------------------------DISSD-GER-
P_troglodytes_ENSPTRP00000047678          --------------------------------------------------------------------------------------------------------------DISSD-GER-
P_pygmaeus_ENSPPYP00000004372             --------------------------------------------------------------------------------------------------------------DISSD-GER-
M_mulatta_ENSMMUP00000021744              --------------------------------------------------------SAPLE--IQGAQPSGRLK----------------LCPHAH----FRELKTKRADEIYPV-MEKE
E_caballus_ENSECAP00000006810             --------------------------------------------------------TDPQE--TQVSQPKDKLK----------------PCSHDH----FRKLKTTKAEEMYPV-MEKK
G_gorilla_ENSGGOP00000011776              --------------------------------------------------------------------------------------------------------------DISSD-GER-
C_familiaris_ENSCAFP00000021904           --------------------------------------------------------LQVLQ--EIQASQVKVRK----------------LCPCDH----SHEPKITNVHEIYPV-MEKE
M_musculus_ENSMUSP00000027009             --------------------------------------------------------TAPHG--LQSSEVQDTLK----------------LCPRDQ----FCKIKTERAKEIYPV-MEKE
R_norvegicus_ENSRNOP00000029448           --------------------------------------------------------TVPQG--IQSTEVQDSLK----------------LCSRDW----FCTMKTERAEEIYPV-MEKE
P_pygmaeus_ENSPPYP00000004373             --------------------------------------------------------MEAGP--PESGESTDALK----------------LCPHEE----FLRLCKERAEEIYPI-KERN
P_troglodytes_ENSPTRP00000041705          --------------------------------------------------------MEAGP--PESGESTDALK----------------LCPHEE----FLRLCKERAEEIYPI-KERN
B_taurus_ENSBTAP00000027820               --------------------------------------------------------TVAGP--DESVGSAATLK----------------LCPHEE----FLKLCKERAGEIYPI-KERK
C_familiaris_ENSCAFP00000031565           --------------------------------------------------------NMPGPTIPDSEESTDTLK----------------LCPPET----FVKMYKEKAEEIYPI-KERK
H_sapiens_ENSP00000347741                 --------------------------------------------------------MEAGP--PESGESTDALK----------------LCPHEE----FLRLCKERAEEIYPI-KERN
M_mulatta_ENSMMUP00000012893              --------------------------------------------------------MEARP--PESGESADALK----------------LCPHEE----FLRLCKERAEEIYPI-KERN
E_caballus_ENSECAP00000010831             --------------------------------------------------------IAAGP--AESAEPTDTLK----------------LCPHEE----YLRLCKERAEEIYPI-KDKK
M_domestica_ENSMODP00000034020            ---------------------------------------------------------LIAS--TAQTGSSGKLK----------------VCSREE----FLMQRRLRVEEIYPV-MEKG
M_domestica_ENSMODP00000034022            --------------------------------------------------------IERT---TMNPGYLDTLK----------------LCSYED----FQQKRKEMEGQIYPV-MEKG
M_mulatta_ENSMMUP00000012894              --------------------------------------------------------IEAGP--PESAESTNTLI----------------LCPHEE----FLRRCKENHDEIYPI-KKRE
P_troglodytes_ENSPTRP00000007279          --------------------------------------------------------IEAGP--PESAESTNILK----------------LCPREE----FLRLCKKNHDEIYPI-KKRE
H_sapiens_ENSP00000376849                 --------------------------------------------------------IEAGP--PESAESTNILK----------------LCPREE----FLRLCKKNHDEIYPI-KKRE
E_caballus_ENSECAP00000021890             --------------------------------------------------------DDLAK--LALSGPKVSLK----------------LCSPEV----VERIWKEKSAEMYPI-MGKS
H_sapiens_ENSP00000260309                 --------------------------------------------------------DNPAM--PTSSGSEGNVK----------------LCSLEE----AQRIWKQKSAEIYPI-MDKS
P_troglodytes_ENSPTRP00000059619          --------------------------------------------------------DNPAM--PTSSGSEGNVK----------------LCSLEE----AQRIWKEKSAEIYPI-MDKS
P_pygmaeus_ENSPPYP00000004374             --------------------------------------------------------IEAGP--PESAESTNTLK----------------LCPREE----FLRLCKKNHDEIYPI-KKRE
M_domestica_ENSMODP00000034033            --------------------------------------------------------IGKWK--VIHDDAIDTLK----------------LCSYAD----FQRIKKEKEGQIYPV-MEKG
G_gorilla_ENSGGOP00000015374              --------------------------------------------------------IEAGP--PESAESTNILK----------------LCPREE----FLRLCKKNHDEIYPI-KKRE
P_pygmaeus_ENSPPYP00000004377             --------------------------------------------------------DNPAM--PTSSGSKGNVK----------------LCSLKE----AQKIWKEKPAEIYPI-MDKS
B_taurus_ENSBTAP00000027821               --------------------------------------------------------DNPVK--LASSGPGGNLK----------------LCPPET----AQRIRKEKSGEIYPI-MERS
M_musculus_ENSMUSP00000027012             --------------------------------------------------------ANLEM--EEPEESLNTLK----------------LCSPEE----FTRLCREKTQEIYPI-KEAN
R_norvegicus_ENSRNOP00000009993           --------------------------------------------------------LNKEG--GAFPGPSGSLK----------------FCPLEI----AQKLWKENHSEIYPI-MKTP
M_musculus_ENSMUSP00000027015             --------------------------------------------------------QNKED--GTFPGLTGTLK----------------FCPLEK----AQKLWKENPSEIYPI-MNTT
O_anatinus_ENSOANP00000016591             --------------------------------------------------------KTLTE--SHPDGSGEILK----------------LCPSEE----REKLQKENEGEIYPV-LVKA
O_cuniculus_ENSOCUP00000000956            --------------------------------------------------------DNQVV--FTFSGP--SLK----------------LCPLET----AQRIWKEKSEEIYPIKMQSS
R_norvegicus_ENSRNOP00000058685           --------------------------------------------------------ANLEM--EEPEESVDTLK----------------LCSSEE----FTRLCREKKQEIYPI-KETN
M_mulatta_ENSMMUP00000012901              --------------------------------------------------------DNPAM--PTSSGSKGNVK----------------LCSQEE----AQRIWKEKPAEIYPI-MVKS
G_gallus_ENSGALP00000001569               ---------------------------------------------------------------PVSSQDLQWIQ----------------QCPLSE----YQRIKEAEGDQIYDIYQPRE
X_tropicalis_ENSXETP00000017024           --------------------------------------------------------EQNKK--TNENTEISSVI----------------HCSDKD----FKEIHDTQGDKIYEM-RKRE
G_aculeatus_ENSGACP00000013201            ------------------------------------------------------------------------------------------VSPHRD----RKLTPLKSVFQIYPA-SKNS
A_carolinensis_ENSACAP00000013361         ------------------------------------------------------------------------------------------------------------AMQIYPI-GDRR
O_cuniculus_ENSOCUP00000006490            --------------------------------------------------------XXXXX--XXXXXXXXXXX----------------XXXXXX----XXXXXXXXXXXIYPI-KDKK
D_rerio_ENSDARP00000034228                --------------------------------------------------------EPIPK--DPAQLKELKVT----------------PCSQQF----KNKILREKGQETYEI-KDKS
T_rubripes_ENSTRUP00000019853             -----------------------------------------------------------QP--QSPRWKVKGHL----------------QLPHQS----MCSGRRNRATKVYPG-TREA
T_rubripes_ENSTRUP00000035020             --------------------------------------------------------VLEGE--TERQRRERALK----------------ISP-GN----HSLLLQSFQ--VYPG-TREA
O_latipes_ENSORLP00000007938              ------------------------------------------------------------N--SHSQRDEPATT----------------VLTAED-----FWKKTQNDPNVYPV-TKAS
T_rubripes_ENSTRUP00000013027             -----------------------------------------------------------ST--AEPQMEGQGSS----------------STP-PS----IDVFWKEKQSDVYPG-TREA
D_rerio_ENSDARP00000059407                -------------------------------------------------------------------------T----------------SGFQEF----KTRLLYANRDDIYTP-VSRT
D_rerio_ENSDARP00000068268                --------------------------------------------------------DLQPI--QADWQRPRQII----------------PCSQET----KNTLLKAHGDDIYTP-RSGT
D_rerio_ENSDARP00000008601                VERRNRNNLCVKCTICTANMTQTYYFCWKCRREWKGVTNNAECC------------GNTGC--GQSVTEPDPLK----------------PCTPEF----KAEKLMTEGKCIYPV-KDKS
C_elegans_C48D1.2                         QDIYSRARSRSRSRALHSSDRHNYSSPPVNAFPSQPSSANSSFTGCSSLGYSSS--RNRSF--SKASGPTQYIF----------------HEEDMNFVDAPTISRVFDEKTMYRN---FS
G_gallus_ENSGALP00000029853               ESCN------------SKRPRLIV--FFCTKPV-----------------------EHSLD--SGDGPPIPPVK----------------HCTPEF----YRDHQ----HLAYKL---IS
A_carolinensis_ENSACAP00000006831         DLLP------------FAYQLFIS----SAEPM-----------------------EHSLD--DGDGPHYPQVM----------------PCTPEF----YRTHE----QLAYKL---KS
D_rerio_ENSDARP00000075318                ----------------------------------------------------------------------------------------------------DKTNT---M-NEYEM---KS
X_tropicalis_ENSXETP00000015203           ESTP------------SRPRRQFC-----REYN-----------------------EESID--DGDGPGTVQL------------------CSVDF----YLSHH----QQAYKM---HS
M_musculus_ENSMUSP00000031895             ESCP------------PHKQLRLS-----TDAT-----------------------EHSLD--NGDGPPCLLVK----------------PCTPEF----YQAHY----QLAYRL---QS
R_norvegicus_ENSRNOP00000022672           ESCP------------PHKQSRLS-----TDTM-----------------------EHSLD--NGDGPPCLQVK----------------PCTPEF----YQAHY----QLAYRL---QS
E_caballus_ENSECAP00000003321             ESCP------------PHKQLRLS-----TDTV-----------------------EHSLD--NGDGPPCLQVK----------------PCTPEF----YQAHY----QLAYRL---QS
B_taurus_ENSBTAP00000024166               ESCT------------RHKRLHLS-----PDAV-----------------------EHSLD--HGDGPPCLQVK----------------PCTPEF----YQTHH----HLAYRL---QS
O_anatinus_ENSOANP00000005545             SVCPVVVCPFLMVLGNSRLQPALSVGDLLPEEM-----------------------EHSLD--NGDGPPCPQVK----------------PCTPEF----YRVHH----HLAYRL---ES
H_sapiens_ENSP00000312664                 ESCP------------LYKKLRLS-----TDTV-----------------------EHSLD--NKDGPVCLQVK----------------PCTPEF----YQTHF----QLAYRL---QS
P_troglodytes_ENSPTRP00000033921          ESCP------------LYKKLRLS-----TDTV-----------------------EHSLD--NKDGPVCLQVK----------------PCTPEF----YQTHF----QLAYRL---QS
P_pygmaeus_ENSPPYP00000017020             -----------------------------------------------------------------------------------------------------GISL---D-NSYKM---DY
M_mulatta_ENSMMUP00000016588              LNT-------------VFWFSVYT-----TDTV-----------------------EHSLD--NKDGPVCLQVK----------------PCTPEF----YQTHF----QLAYRL---QS
O_anatinus_ENSOANP00000000517             -----------------------------------------------------------------------------------------------------SASL---D-DRYRM---DY
T_rubripes_ENSTRUP00000037606             EAVP------------GVCVCVCE-----TESL-----------------------EVSLD---ADSPINTPVL----------------PCTPDF----YLSHF----QQSYKM---AS
C_familiaris_ENSCAFP00000005409           ESCP------------PQKQLRLS-----PDTV-----------------------EHSLD--NGDGPPCLQVK----------------PCTPEF----YQTHY----QLAYRL---QS
E_caballus_ENSECAP00000019797             -----------------------------------------------------------------------------------------------------GISL---D-SSYKM---DY
T_guttata_ENSTGUP00000013612              ESCN------------SKRPRWL-------EPM-----------------------EHSLD--NRDGPSIPPVK----------------YCTPEF----YHNHQ----HLAYKL---TS
P_troglodytes_ENSPTRP00000054330          -----------------------------------------------------------------------------------------------------GISL---D-NSYKM---DY
H_sapiens_ENSP00000311032                 -----------------------------------------------------------------------------------------------------GISL---D-NSYKM---DY
P_pygmaeus_ENSPPYP00000020323             ESCP------------LYKKLRLS-----TDTV-----------------------EHSLD--NKDGPVCLQVK----------------PCTPEF----YQTHF----QLAYRL---QS
E_caballus_ENSECAP00000010379             -------------------------------------------------------------------------------------------------------------QEAYDM---SG
M_mulatta_ENSMMUP00000015808              -----------------------------------------------------------------------------------------------------GISL---E-NSYKM---DY
O_latipes_ENSORLP00000015114              DSEG------------LQLEMRTN-----TESM-----------------------ESSLD---ADSPINTPVL----------------ACSADF----YLSHC----QQSYRM---NS
G_aculeatus_ENSGACP00000013740            EVVA------------AKRART-Q-----AESM-----------------------EFSLD---ADSPINSPVL----------------PCTPDF----YLSHC----HQSYRM---NS
O_cuniculus_ENSOCUP00000001859            ESCS------------PHKQPRLS-----TETE-----------------------ERSLD--NGDGPPCLQVK----------------PCTPEF----YQTHY----QLAYRL---QS
M_domestica_ENSMODP00000001598            DSCP------------PHKQLRLS-----VETM-----------------------EHSLD--NGDGPPSLQVK----------------PCTPEF----YQTHQ----HLAYRL---QS
T_nigroviridis_ENSTNIP00000009934         ----------------------------------------------------------------------------------------------------KSARY---S-FRYSL---DF
T_rubripes_ENSTRUP00000040691             ----------------------------------------------------------------------------------------------------KPAAY---S-FRYSL---DF
T_nigroviridis_ENSTNIP00000010874         EAVP------------AKRART-------QESM-----------------------EISLD---ADSPINTPVC----------------PCTPDF----YHSHS----QQSYKM---TS
T_guttata_ENSTGUP00000006879              -----------------------------------------------------------------------------------------------------GILP---D-YSYRM---DY
D_rerio_ENSDARP00000083664                EICK------------KKNKHTHT-----HKSM-----------------------EMCLD---ADSPVTTAVL----------------PCTPEF----YQSHR----PQAYPM---RS
G_aculeatus_ENSGACP00000024809            ----------------------------------------------------------------------------------------------------QSGED---K-YRYKM---DY
M_domestica_ENSMODP00000004412            FLYFIDAVLVSAHNLFPLELIKR--QPTFSKVLSLLYKLRFPF------------------------------------------------CPPPQ------------VGQVYTL---NS
G_gallus_ENSGALP00000017288               -----------------------------------------------------------------------------------------------------GILP---D-DSYRM---DY
E_caballus_ENSECAP00000015102             TPGKLTPVVLGPEELWLAKLRPEVLRPEVPRPVDIGSGGFSDV------------------------------------------------RAQDR----LRGNA----DLAYVL---NA
E_caballus_ENSECAP00000013731             ----------------------------------------------------------------------------------------------------RNREP---T-YQYNM---NF
C_familiaris_ENSCAFP00000032189           -----------------------------------------------------------------------------------------------------KYLT---K-LHYKM---DY
C_familiaris_ENSCAFP00000023821           ------------------------------------------------------------------------------------------------MVDSEIRQAQLLAQEAYDM---SG
R_norvegicus_ENSRNOP00000014096           -----------------------------------------------------------------------------------------------------GIYL---D-SSYKM---DY
M_domestica_ENSMODP00000005556            ----------------------------