10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000366237 --------MEVTGDAGVPESGEIRTLKPCLLRRNYSREQHGVAASCLEDLRSKACDILAIDKSLTPVTLVLAEDGTIVDDDDYFLCLPSNTKFVALASNEKWAYNN-SDGGTAWISQESF M_mulatta_ENSMMUP00000015307 --------MEVTGDAGVPESGEIRTLKPCLLRRNHSREQHGVAASCLEDLRSKACDILAIDKSLTPVTLVLAEDGTIVDDDDYFLCLPSNTKFVALANNEKWAYNN-SDGGTAWISQESF P_pygmaeus_ENSPPYP00000002201 --------MEVTGEAGVPESGEIRTLKPCLLRRNYSREQHGVAASCLEDLRSKACDILAIDKSLTPVTLVLAEDGTIVDDDDYFLCLPSNTKFVALANNEKWAYNN-SDGGTAWISQESF P_troglodytes_ENSPTRP00000000259 --------MEVTGDAGVPESGESRTLKPCLLRRNYSREQHGVAASCLEDLRRKACDILAIDKSLTPVTLVLAEDGTIVDDDDYFLCLPSNTKFVALASNEKWAYNN-SDGGTAWISQESF E_caballus_ENSECAP00000015281 --------MEVVGDASGSEPGEIRALKPCLLRRNHSREQHGVAASCLEELRSKACDILAIDKSLAPVTLVLAEDGTIVDDDDYFLCLPSNTKFVALARNEKWAYHN-SDGGTAWISQESF B_taurus_ENSBTAP00000017999 --------MEVPGGPAAPEPGEIRALKQCLLRRNKSREQHGVAASCLKELRNKACDILAIDKSLAPVTLVLAEDGTIVDDDDYFLCLPANTKFVVLAGNEKWTHNSVSDGGTAWITQESF R_norvegicus_ENSRNOP00000018353 --------MELSRGASAPDPDDVGPLKPCLLRRNHSREQHGVAASSLEELRSKACELLAIDKSLTPVTLVLAEDGTIVDDEDYFLCLPSNTKFVALACNEKWAYND-SDGGTAWLSQESF M_musculus_ENSMUSP00000030816 --------MELSRGASAPDPDDVRPLKPCLLRRNHSRDQHGVAASSLEELRSKACELLAIDKSLTPITLVLAEDGTIVDDDDYFLCLPSNTKFVALACNEKWIYND-SDGGTAWVSQESF C_familiaris_ENSCAFP00000024677 --------MALVGAA----EAETRTLKPCVLRRNHSREQHGVAASSLEELRRKACDILAIDKSLAPVTLVLAEDGTIVDDDDYFLCLPSNTKFVALASNEKWTYNN-SDGGTAWISQESF O_anatinus_ENSOANP00000004455 --------MDTSGG-----SADNLDPKPCVLRRNGSREQHGVAASGLKELRHKACDILAIDKSMEPITLVLAEDGTIVDDEDYFLCLPSNTKFVALTRNEKWEYSN-MDGGTAWLCQESV M_domestica_ENSMODP00000003227 --------CGFPRPEMESSEETTGTLKPCLLRRNRSREHHGAAASCLEDLKQKACDILEIDKSLEPITLVLAEDGTIVDDEDYFLCLPSNTKFVALTCNEKWTYSN-TDGGTAWLSQESF A_carolinensis_ENSACAP00000011707 -------------------------LKQCLLRSNGRQEQHGVAAASLQELRSKACELFAIDTASQPVTLVLAEDGTIVDDEDYFLCLPPNTKFVALAKDEKWACSS-IDGGTAWLEGEVT T_guttata_ENSTGUP00000003392 ----------KSPRAAAERHSMAARLKRCVVRRRDGPEQHGVAASCLRELRDKACGVLAIDKAREPITLVLAEDGTIVDDEDYFLCLPANTKFVALAKDEKWSSKS-LDSGTSWLSESV- G_gallus_ENSGALP00000004446 ------TRPSAPRAGHRPSAAMAARLKPCVVRRGDGREQHGLAASSLRELRDKAGSALAIGEDGRPITLVLAEDGTIVDDEDYFLCLPSNTKFVALAEGERWSGRS-ADSRSAWLSEPA- G_gorilla_ENSGGOP00000012405 --------MEVTGDAGVPESGEIRTLKPCLLRRNYSREQHGVAASCLEDLRSKACDILAIDKSLTPVTLVLAEDGTIVDDDDYFLCLPSNTKFVALASNEKWAYNN-SXXXXXXXXXXXX X_tropicalis_ENSXETP00000013820 ---------------------MASFQKACVVSLPGSKDRHGVAAASLEELLEKACKKFSLDSSVEPITLVLAEDGTIVEDEDYFLCLPPNTKFVILTGNKKWAPTT-LDGGTAWLARDSM T_rubripes_ENSTRUP00000031069 -------MPISQGSASNACENRMADKKPCRVCNFTRQKSYGVAVPSLYDLKTKGSEFLGFSAT-DPVTVVLEDDGTIVADDAYFLCLPPNTKFMLLHEKETWAPVRRMDGGTAWMARDSV O_latipes_ENSORLP00000006486 ----------------------MTDGKACKVCNFTRQKSYGVSAPSLDDLKKKGSEYLGFSPG-DPVKVVLENDGTIVEDQTYFLCLPSNTKFMLLHDKETWSPARKIDGGTAWMQRESV T_nigroviridis_ENSTNIP00000018232 ---------------------EMTDKKPCRVCNFTRQKSYGVAVPSLMELKTKGSEFLGFRSS-DPVTVVLEDDGTIVADESYFLCLPPNTKFMLLHEKEMWAPVRRMDGGTAWMARDSL D_rerio_ENSDARP00000072629 ----------------------MTELKPCKVCNVSRQKCYGLAVTSLDQLRIKGAESLGFCPS-ASVSVVLENDGTIVEDEAYFMCLPANTKFMLLDANEIWMHSHQIAGGTAQSCRESM G_aculeatus_ENSGACP00000009395 -----------SQVHQGSSKPRMTDRKPCKVCNFTRQKSYGVVVPSLDELKLKGSEFLGFSPG-QPVTVVLDNDGTIVEDQAYFLCLPLDTKFMLLHEKEKWSPVRRVDGGTAWMARDSM T_guttata_ENSTGUP00000016850 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL014825-PA MHGATIERVRLVKDLGISLDCKLRFIEQKFIKDITRAIKKAVVAGSLDEVRSKAAEKF---NRPELPNIHLDSDGTEVDDEDYFQTLEPNAELIVVFPGEQWIDP------THYVTITTH 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000366237 --DV-DE--TD--SGAGLKWKNVARQLKEDLSSIILLSEEDLQMLVDAPCSDLAQELRQSCATVQRLQHTLQQVLDQREEVRQSKQLLQLYLQALEKEGSLLSKQEESKAA-FGEE---V M_mulatta_ENSMMUP00000015307 --DV-DE--TD--RGAGLKWKNVARQLKEDLSSIILLSEEDLQMLVDAPCADLAQELLQSCATVQQLQHTLQQVLDQREEVRQSKQLLQLYLEALEKEGSLLSKQEESKAA-LGEE---A P_pygmaeus_ENSPPYP00000002201 --DV-DE--TD--SGAGLKWKNVARQLKEDLSSIILLSEEDLQMLVDAPCSDLAQELHQSCATVQRLQHTLQQVLDQREEVRQSKQLLQLYLQALEKEGSLLSKQEESKAA-FGEE---A P_troglodytes_ENSPTRP00000000259 --DV-DE--TD--SGAGLKWKNVAGQLKADLSSIILLSEEGLQVLVDAPCSDLAQELRQSCATVQRLQHTLQQVLDQREEVRQSKQLLQLYLQALEKEGSLLSKQEESKAA-FGEE---V E_caballus_ENSECAP00000015281 --DV-DE--TD--SGAGLKWKNVARQLKEDLSSIILLSEDDLQVLIDVPCSDLAQELCQSCVTVRGLQNTLQQVLDQREEARQSKQLLELYLQALEKEGSVLSKQQESKAG-FSDE---S B_taurus_ENSBTAP00000017999 --DR-DE--TD--SGAGLKWKNVARQLKEDLSSIILLSEEELQMLIDVPCSELAQELSQSHVAVQGLQNTLQQVLDQREEARQSRQLLELYLRALEKEGGILSKQQESRAD-LGDE---S R_norvegicus_ENSRNOP00000018353 --DT-DQ--TD--SGAGVKWKNVARQLKEDLSSIILLSEEELQALIDIPCAELAQELCQSCATVQGLQSTLQQVLDQREEARQSKQLLELYLQALEKEGSILSNQNESKAA-LGEE---L M_musculus_ENSMUSP00000030816 --EA-DE--PD--SRAGVKWKNVARQLKEDLSSIILLSEEDLQALIDIPCAELAQELCQSCATVQGLQSTLQQVLDQREEARQSKQLLELYLQALEKEGNILSNQKESKAA-LSEE---L C_familiaris_ENSCAFP00000024677 --DV-DE--TD--SGAGLKWKNVARQLKEDLSSIILLSEEDLQVLIDVPCSDLAQELCQSCVTVQGLQDTLQQVLDQREEARQSKQLLELYLQALEKEGGILSKQQASSGD-LSDE---V O_anatinus_ENSOANP00000004455 --DE-DE--TD--GRVGLKWKNVARQLREDLSSIILMSEEDLQVLIDAPCSDLALELAQSHVKTQGLQNTLQQVLDKREEARQSKQLLELYLQALDKEGSLLTKQAEPEAGFFPEE---M M_domestica_ENSMODP00000003227 --ESRDE--VD--SSGGCRWKNLARQLKGDFSSIVLLAEEDLQVLIDVPCPDLAQELSQSPEKTQDLQNTLQQVLDQREEARQSRQLLQLYLQALEKEGGILAKQAESEAT-LDEK---M A_carolinensis_ENSACAP00000011707 --DI-DG--PE--SGE-EKWQRLARQLKDDLSTIILMSEEDLQALIDVPCLDLARELSDTQAKVQALQETLQQVLDRREEERQSRQLLELYLQAVKNEDHIVPKREATDTA--MEE---A T_guttata_ENSTGUP00000003392 -----DE--VD--SAA-EKWKQLARQLKDDLSNIILMSEEDLQVLIDVPCSDLAEELAQSETKVHVLQDTLQQVLDRREEERQSRQLLELYLEALKTEDSILSKVAEPEAA-PRKE---M G_gallus_ENSGALP00000004446 -----DE--VD--SGA-ERWRQLARQLRADLSNIILMSEEDLQVLIDVPRSDLAEELAQNQTKTQVLQDTLQQVLDRREEERQSKQLLELYLEALKNEDSILSKVAESESV-PRKE---M G_gorilla_ENSGGOP00000012405 --XX-XX--XX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXX---X X_tropicalis_ENSXETP00000013820 --EVEDENMVD--GADLTRWKNLALQLKEDLSNIILMSESELQILTEVSVDELAGVVGVSCEKVQSLQNIIQRVMDRREEERQSKQLLELYLEAVKKE-----KTSEPDSI-YFAE---- T_rubripes_ENSTRUP00000031069 -IET-DA--VDFSGGVNAPWWFLTQQLKNDLASIILMSEEDLQMLVDVPHQQLASAMGFQEKKAQDLQETLQRVLDRRDEERQSKELLQLYLNAVAKEKEQ-AKTSQARKE-ILQDEVIV O_latipes_ENSORLP00000006486 MLEM-DT--VD-TGSSLAPWLDLAQQLKQDLTSIILMSEADLQLLVDAPSTELAAALGFQVKKAEDLQETLQNVLDRREEERQSKELLQLYLRTVEKEDKQLEEASQSSTG-TGGD---V T_nigroviridis_ENSTNIP00000018232 MMET-DA--VDFSGGADAHWWFLAQQLKQDLTSIILMSEEDLQTLVDVPHQQLASAMDFQEKKAQDLQDTLQRVLDRREEERQSKELLQLYLKAVAKEREQ-DESSQAAEA--------A D_rerio_ENSDARP00000072629 --EV-D-------GGF-DSWRSLAEQLRQDLASIILMSEADLQSLIDVPRSDLASALEFSQQKTHVLQDTLQRVLDRREEERQSKDLLRLYLKAMEREGTW--DPQEESAN--------L G_aculeatus_ENSGACP00000009395 LVEA-DT--VDASSAA-APWLDLAQQLKRDLASIILMSDEDLQTLVDAPSIELASAVGFQEKKAQDLQETLQRVLDRREEERQSKELLQLYLKAAEKEGGQ--QADQSRPG-QAGD---- T_guttata_ENSTGUP00000016850 ------------------------------------------KVLIDVPCSDLAEELAQSETKVRVLQDTLQQVLDRREEERQSRQLLELYLEALKTEDSILSKVAEPEAA-PRKE---M A_aegypti_AAEL014825-PA -KETGDT--TDSPEVERIHLKKLVAQMKSNLCNVSVLSEPDLELLSNMDPNSVADITGRD--FIEQLKEASGRILHEKRQALDAIELLKLIAKQKATIPSIVHNIPGGEPN-EDDD---E 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000366237 DAVDT-GISR-ETSSDVALASHILTALREKQAPELSLSSQDLELVTKEDPKALAVALNWDIKKTETVQEACERELALRLQQ-------------------TQSLHSLRSISASKASPPGD M_mulatta_ENSMMUP00000015307 DAVDT-GISR-EASSDVTLASHILTALREKPAPELSLSSQDLELVTREDPKALAVALNWDIRKTETVQEACERELALRLQQ-------------------MQSLHSLRSISARKASPPGE P_pygmaeus_ENSPPYP00000002201 DAVDT-GISR-ETSSDVALASHILTALREKPAPELSLSSQNLELVTKEDPKALAVALNWDIKKTETVQEACERELALRLQQ-------------------MQSLHSLRSISSSKASRPGD P_troglodytes_ENSPTRP00000000259 DAVDT-GISR-ETSSDVALASHILTALREKPAPELSLSSQDLELVTKEDPEALAVALNWDIKKTETVQEACEQELTLRLQQ-------------------MQSLHSLRSISASKASPPGD E_caballus_ENSECAP00000015281 DAVDT-GLSR-ESSSETALTSQLLTALKEKPAPELSLSSQDLELVTKEDPKALAVALKWDIKKTETVQQACNQELSLRLQQ-------------------IQSLHSLRNISARKNSLPGE B_taurus_ENSBTAP00000017999 DAVDT-GI-R-ESFSEVTPASQILLALKEKPAPELSLSSQDLELVAKEDPKALAVALNWDLKKTEAVQQACNQELRLRLQQ-------------------VQSLRSLRSISARTSSLPGD R_norvegicus_ENSRNOP00000018353 DAVDT-GVGG-EVASEVMLRSQILAALKEKPAPELSLSSQDLESVSKEDPKALAVALSWDIKKAETVQQACTTELALRLQQ-------------------VQSLHSLRNLSAKRKPLPGD M_musculus_ENSMUSP00000030816 DAVDT-GVGR-EMASEVLLRSQILTTLKEKPAPELSLSSQDLESVSKEDPKALAVALSWDIRKAETVQQACTTELALRLQQ-------------------VQSLHSLRNLSARRSPLPGE C_familiaris_ENSCAFP00000024677 DAGDT-GSNG-QSTSESALTSHVLTTLKGKLAPELSLSSQDLELVTREDPRALAAALSWGLGKTEAVQQACCQELSLRLQQ-------------------VQSLHSLRSVSAR-SPQPAR O_anatinus_ENSOANP00000004455 DEVDTGGVSP-EGASKIALSNQILSALK-KPSPELSLSSQDLELVTQEDPSALASALSWDKERADAVHRACVQELARRHQQ-------------------LQSLHSLRNVSARKKPVPLE M_domestica_ENSMODP00000003227 DEVDS------RGAGHITLSSHVLTVLKEKSFPELSLSSQDLELVTKEPPEALARALSWDLEKAEAVQGACEQQLSLRLQQ-------------------VQSLNSLHSLSARKNSLTEE A_carolinensis_ENSACAP00000011707 DTVDA-GGSS-RVAATVPLSSHILTALREKTAPELSLDSQDLELVNKEDPDVLAQALSWEKTKVLALQEACEQELSRRLQQ-------------------VQALHSLRSFSKGK------ T_guttata_ENSTGUP00000003392 DVVDT-GTSSTDTSATTALSGQVLAALKEKRAPELCLDSQDLELVLKEDAAALASALGWDEQKAGALQEACEQELSKRLRQ-------------------VQTLHSLRSTSKGKKALPWG G_gallus_ENSGALP00000004446 DVVDT-GTSSAGASARTALSDHIFAVLKEKPAPELCLDSQTLELVVKEDTQALAAALSWDKQKAKAVQQACDQELSKRLQQ-------------------VQTLHSLRSTSRGKKALPCG G_gorilla_ENSGGOP00000012405 XXXXX-XXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLVTKEDPKALAVALNWDIKKTETVQEACERELALRLQQ-------------------MQSLHSLRSISASKASPPGD X_tropicalis_ENSXETP00000013820 DEVDSGGNTQTQLSCKSLVSSHIMEILKKKDLPHLSLSNKELENVNEENTEVLMMSLGWKEQKILDLKASCQQELKRRDEQ-------------------VQSLKNISHIN---KTLP-- T_rubripes_ENSTRUP00000031069 DCVGC-----TSVFETLGFMSRTLMVLKGKTNPETRLSTMDLQMIVSRGVEAMAEVLGWDNTRTSALLQACEAELTGRLQQ-------------------VQAVQSIRS----------- O_latipes_ENSORLP00000006486 DVPDG-----SEVDSASGFMSRTLMVLKGKTSPETRLSTEDLQMVVTRGVDAMKQVLGWDEARTSALLQACEAELSRRLQQ-------------------IQAMQSISN-TQLD-----G T_nigroviridis_ENSTNIP00000018232 DGSDL-----TEVDSATGFMSRTLMVLKGKTSPETRLSTEDLQMIVGRGVEAMVDVLGWDDTRTSALLQACEAELTRRLQQ-------------------VQAVQSIRS----------- D_rerio_ENSDARP00000072629 DETDG-----VQVEAAAGFSSTTLMVLRDKRYPETRLSNQELQMVVKQGAKAMMEVLVWDSERTSALVQACDNELSKRLQR-------------------VQALQSLNTQNQSDPQAHVE G_aculeatus_ENSGACP00000009395 LGVET-----MEVDSGSGFVSRTLMVLKGKTSPETRLSTEDLQMVVTRGVEAMERVLGLDRTRTSALLQACEAELTGRLQQ-------------------IQAVQSIRGSAQLD-----G T_guttata_ENSTGUP00000016850 DVVDT-GTSSTDASATTALSGQVLAALKEKRAPELCLDSQDLELVLKEDAAALASALGWNKQKAGALQEACEQELSKRLRQ-------------------VQTLHSLRSTSKGKKTLP-- A_aegypti_AAEL014825-PA DGDDD--------NYVEGCSS--MSILGDGHPLPLAPDDVDGSSSSANQRRSSSSSISSGKQITLELDPRTLANFHHQYQQDPPSAGSASGGTLVHPPVNPAASTDLANASLNSGANPGD 370 =========+====== H_sapiens_ENSP00000366237 LQ-NPKRARQDPT--- M_mulatta_ENSMMUP00000015307 RQ-NPKRAKQKPT--- P_pygmaeus_ENSPPYP00000002201 LQ-NPKRARQDPT--- P_troglodytes_ENSPTRP00000000259 LQ-NPKRARQDPT--- E_caballus_ENSECAP00000015281 LQ-NPKRAKQDPTEYS B_taurus_ENSBTAP00000017999 ME-NPKRTRRDPM--- R_norvegicus_ENSRNOP00000018353 PQ-SPKRAKRRTS--- M_musculus_ENSMUSP00000030816 PQ-RPKRAKRDSS--- C_familiaris_ENSCAFP00000024677 PQ-EPKRARREPT--- O_anatinus_ENSOANP00000004455 DQSSSKRAKRQPP--T M_domestica_ENSMODP00000003227 PG-SLKRAK------- A_carolinensis_ENSACAP00000011707 ---------------- T_guttata_ENSTGUP00000003392 DWPSAKRKK------- G_gallus_ENSGALP00000004446 DGLSSKRKK------- G_gorilla_ENSGGOP00000012405 LQ-NPKQARQDPT--- X_tropicalis_ENSXETP00000013820 ---------------- T_rubripes_ENSTRUP00000031069 ---------------- O_latipes_ENSORLP00000006486 RRQSSGTSTEDSV--- T_nigroviridis_ENSTNIP00000018232 ---------------- D_rerio_ENSDARP00000072629 RKTRAKRCKKHSH--- G_aculeatus_ENSGACP00000009395 SRGSS----------- T_guttata_ENSTGUP00000016850 ---------------- A_aegypti_AAEL014825-PA TSNI------------