10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ E_caballus_ENSECAP00000004553 ----------------------MSS-----HLVEQPPPLHNN------NNNCEEGEQSLPPPAGLNSSWVELPMN-SSNGN-------------------------------D-NGNGKN R_norvegicus_ENSRNOP00000014798 ----------------------M-S-----HLVEPPPPLHNN------NNNCEEGEQSLPPPAGLNSSWVELPMN-SSNGN-------------------------------G-NGNGKN B_taurus_ENSBTAP00000033770 ----------------------MSS-----HLVEQPPPPHNN------NNNCEEGEQSLPPPAGLNSSWVELPMN-SSNGN-------------------------------D-NGNGKN P_pygmaeus_ENSPPYP00000020684 ----------------------MSS-----HLVEPPPPLHNN------NNNCEESDQSLPPPAGLNSSWVELPMN-SSNGN-------------------------------D-NGNGKN M_musculus_ENSMUSP00000022634 ----------------------M-S-----HLVEPPPPLHNN------NNNCEEGEQPLPPPAGLNSSWVELPMN-SSNGN-------------------------------E-NGNGKN M_musculus_ENSMUSP00000099113 ----------------------M-S-----HLVEPPPPLHNN------NNNCEEGEQPLPPPAGLNSSWVELPMN-SSNGN-------------------------------E-NGNGKN O_cuniculus_ENSOCUP00000009082 ----------------------MSS-----HLVEPPPPLHNN------NNNCEDGDQHLPPPTGLNSSWVELPMN-SSNGN-------------------------------D-NGNGKN M_mulatta_ENSMMUP00000032171 ----------------------MSS-----HLVEPPPPLHNN------NNNCEESGQSLPQPAGLNSSWVELPMS-NSNGN-------------------------------D-NGNGKN H_sapiens_ENSP00000370003 ----------------------MSS-----HLVEPPPPLHNN------NNNCEENEQSLPPPAGLNSSWVELPMN-SSNGN-------------------------------D-NGNGKN P_troglodytes_ENSPTRP00000034406 ----------------------MSS-----HLVEPPPPLHNN------NNNCEENEQSLPPPAGLNSSWVELPMN-SSNGN-------------------------------D-NGNGKN C_familiaris_ENSCAFP00000034684 ----------------------------WICFEARQNSYQNSPHSHLHMTEFGSAVVNLSYLTCPTGSWVELPMN-SSNGN-------------------------------D-NGNGKN T_guttata_ENSTGUP00000004349 ----------------------------------------------------------SFPPPALNSSWVELQMNGNGNSN-------------------------------D-NSNGKN M_domestica_ENSMODP00000027977 ----------------------MSS-----PLVEQPPPLPNN------NNN-NEGEQPLAPPAGLNSSWVELQMNGNGNGN-------------------------------DGNGNGKN A_carolinensis_ENSACAP00000006002 ---------------------------------------HNN------NNN--PPPEGTPAEAGLNSSWVELQMNGNGNGN-------------------------------D-NGNTKN R_norvegicus_ENSRNOP00000055295 ----------------------MSHLVKLLPLNNNNNNNNNNDNDNNNDNNCEEGEQPLPLPSGLNSCWEELPMN-SSNGN-------------------------------D-NENSKN R_norvegicus_ENSRNOP00000049965 ----------------------LGM-----WLQSPPPPHHHHHHHHHRNNNCKEGEQPLPPPSGLNSSWVELPMN-SSNGN-------------------------------D-NGNGKN T_nigroviridis_ENSTNIP00000007933 --------------------------------------------MSEAAN----TTSDNNGDAGLNGSWVELEMNKGAPGSVQSTSTT------------GPAAGLLPLPQ-VDEEEAMV X_tropicalis_ENSXETP00000022422 ----------------------MS---------------ENN------NNN--------GEEAALHGSWVELQMNGNGNNN-------------------------------D---SNRN T_rubripes_ENSTRUP00000017630 --------------------------------------------MSEAAN----STTDNNGDAGLNGSWVELEMNRGAAGSVQSTSTT------------GPAAVLLPLPQ-VEEEEAMV G_aculeatus_ENSGACP00000024002 --------------------------------------------MSAAADAANVSPADRAGDSGLNGSWVELEMNRGTAGSAQSPSA---------------APGLLPLPQ-VEEEEAMV G_gallus_ENSGALP00000000309 ----------------------MSS-----P---QEPPHHNN------NNN--PPAEGTQTEPGLNSSWVELQMNGNGNSN-------------------------------D-NGNGKN D_rerio_ENSDARP00000038022 --------------------------------------------MSDAA-----APADNNGEPGLNGSWVELEMNRNAASLSSSSASV-----------------PPPLAQVVEEDDGMV G_aculeatus_ENSGACP00000015037 -------------------------------------------NMSTAA-----AQQNNNEEPGLHGSWVELKLNGNTGNPGVQTSLPETSAADQINANAGMSQTLQTLEDVPESDETLI O_latipes_ENSORLP00000015175 --------------------------------------------MSTVA-----APENNNEEPGLQGSWVELELNGNTGVQGEPISLSLTPAADQINANSSINQSLQTLE-VAESAESLI D_rerio_ENSDARP00000036535 --------------------------------------------MSTTA----AAQLNNNEEPGLNGSWVELEMNGNTQHQSPSLPSLLG------NGNQGEPQTSQALEAVQEEEEVLT T_rubripes_ENSTRUP00000001438 -------------------------------------------NMSTAA-----APRNNNDEPGLHGSWVELELNGNTGSQDVQAGLLITPAADQINANAGTSHTFQTLQVASEGDEAVA R_norvegicus_ENSRNOP00000041876 -------------------------------------TMSNLVEQSLPLHNNCEEGYPLPPPAGLNGSLVELLMNSSKGND---------------------------------SGNGKN M_domestica_ENSMODP00000024552 ---------------------------------------------------HGQRGSS-SLILHAAGSWVELHFSSNGGGP--------------------------------------- G_gallus_ENSGALP00000017040 ------------------------------------------------------------------GSWVELHFSSNGNGN---------------------------------GNSVAA P_pygmaeus_ENSPPYP00000003236 ---------------------------------------------------MSQNGAPGMQEESLQGSWVELHFSNNGNGS--------------------------------------- E_caballus_ENSECAP00000015204 ------------------------------------------------------------------GSWVELHFSNNGNGS--------------------------------------- G_aculeatus_ENSGACP00000012570 ----------------------------------------------------FLKHGTMSSDESLQGSWIELHFSGNGSQS----------------------------------ASLPL D_rerio_ENSDARP00000096193 ---------------------------------------------------YKNHNKTRMLFGFSSGSWVELHFNNGGGST------------------------------------SKA O_latipes_ENSORLP00000007433 ----------------------------------VSHLYSLTPSIHPSSNRKAQETIGLPPSLFCSCSWVELHFSGNGSQG----------------------------------TCHRG H_sapiens_ENSP00000357625 ---------------------------------------------------MSQNGAPGMQEESLQGSWVELHFSNNGNGG--------------------------------------- P_troglodytes_ENSPTRP00000005394 ---------------------------------------------------MSQNGAPGMQEESLQGSWVELHFSNNGNGG--------------------------------------- G_gorilla_ENSGGOP00000014167 ---------------------------------------------------MSQNGAPGMQEESLQGSWVELHFSNNGNGS--------------------------------------- M_mulatta_ENSMMUP00000029538 ---------------------------------------------------MSQNGAPGMQEESLQGSWVELHFSNNGNGS--------------------------------------- R_norvegicus_ENSRNOP00000023477 ---------------------------------------------------MSQSG-----EENLQGSWVELHFS-NGNGS--------------------------------------- C_familiaris_ENSCAFP00000033658 GHCRLSTALSPGAPRGRAPRVKAVLIPEQKQNRPVPGRGRRAPAQRRPSDAMSHSGTPGLQEENLQGSWVELHFSNNGNGS--------------------------------------- M_musculus_ENSMUSP00000101718 ---------------------------------------------------MSQSG-----EENLQGSWVELHFS-NGNGS--------------------------------------- R_norvegicus_ENSRNOP00000016874 ---------------------------------------------------MSQSG-----EENLQGSWVEQHFS-NGNGS--------------------------------------- X_tropicalis_ENSXETP00000053966 ---------------------------------------------------MSENEGPNLQDEHLQGSWVELHFSNNGNFP-----------------------------------TTQL O_anatinus_ENSOANP00000019225 -------------------------------------------------------------------SWVELQMNDNGNGN-------------------------------D-NGNGKS B_taurus_ENSBTAP00000023684 ---------------------------------------------------MQESEKPGPQAESPSGSWVELHFGSNGNGS--------------------------------------- O_latipes_ENSORLP00000015347 --------------------------------------------MSDAAN--TASTDNNGGDSGLNGSWVELEMNRAHQAQASLTG--------------GLAPGLLPLPQ-VEEEEAIV O_cuniculus_ENSOCUP00000002192 -------------------------------------------------------------------SWVELHFSNNGNGN--------------------------------------- G_gorilla_ENSGGOP00000008208 ----------------------MSS-----HLVEPPPPLHNN------NNNCEENDQSLPPPAGLNSSWVELPMN-SSNGN-------------------------------D-NGNGKN T_nigroviridis_ENSTNIP00000016323 --------------------------------------------------------MSFQTDDGFQESWVELHFGGTASQS-----------------------------------TSHH T_rubripes_ENSTRUP00000015895 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000007888 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000011996 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000021335 ----------------------------------------------------MSLPGPQAPEDGLHGSWVELEELITAVSR----------------------------------RESPA O_latipes_ENSORLP00000006124 ----------------------------------------------------MSLSGSQTPEDGLYGSWVELEELMAAVSR----------------------------------RESLT T_rubripes_ENSTRUP00000046089 ----------------------------------------------------MSLSGSHTPEDGLYGSWVELEELIAAVSR----------------------------------RESLT T_nigroviridis_ENSTNIP00000017287 ----------------------------------------------------MSVSGSHTPEDGLYGSWVELEELIAAVSR----------------------------------RESLT D_rerio_ENSDARP00000037307 ----------------------------------------------------MALSGSQSPDDALHGSWVELEGLVASANQ----------------------------------TEGES D_rerio_ENSDARP00000032168 ----------------------------------------------------MSTQKVIPKEESLHDSWVELHFDSSSEHS--------------------------------------- A_aegypti_AAEL006711-PA ----------------------------------------MFKSINLTSEPNKMSATPRSSEDLLGESWIELSSSTNTCPK--------------------------------------- A_gambiae_AGAP001411-PA ---------------------------------------------------------GGSSNNFVPTGTTMLAGAVGT--K--------------------------------------- 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ E_caballus_ENSECAP00000004553 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRASSHCDS----------P----SP-QEDGQIMFDVEMHTSRDHSSQSEE---EVVEGE---KDVDAL-KKSVDWVSNWSSR R_norvegicus_ENSRNOP00000014798 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRGSSHCDS----------P----SP-QEDGQIMFDVEMHTSRDHSSQSEE---EVVDGE---KEVEAL-KKSADWVSDWSSR B_taurus_ENSBTAP00000033770 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRGSSHCDS----------P----SP-QEDGQIMFDVEMHTSKDHSSQSEE---EVAEGE---KEVDAL-KKSVDWVSDWSSR P_pygmaeus_ENSPPYP00000020684 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRGSSHCDS----------P----SP-QEDGQITFDVEMHTSRDHSSQSEE---EVVEGE---KEVEAL-KKSADWVSDWSSR M_musculus_ENSMUSP00000022634 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRGSSHCDS----------P----SP-QEDGQIMFDVEMHTSRDHSSQSEE---EVVEGE---KEVEAL-KKSADWVSDWSSR M_musculus_ENSMUSP00000099113 GGLEHVPSSSSIRNGD-MEKILLDAQH-ESGQSS---SRGSSHCDS----------P----SP-QEDGQIMFDVEMHTSRDHSSQSEE---EVVEGE---KEVEAL-KKSADWVSDWSSR O_cuniculus_ENSOCUP00000009082 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRGSSHCDS----------P----SP-QEDGQIMFDVEMHTSRDHSSQSEE---EVVEGE---KEVEAL-KKSADWVSDWSSR M_mulatta_ENSMMUP00000032171 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRGSSHCDS----------P----SP-QEDGQIMFDVEMHTSRDHSSQSEE---EVVEGE---KEVEAL-KKSADWVSDWSSR H_sapiens_ENSP00000370003 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRGSSHCDS----------P----SP-QEDGQIMFDVEMHTSRDHSSQSEE---EVVEGE---KEVEAL-KKSADWVSDWSSR P_troglodytes_ENSPTRP00000034406 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRGSSHCDS----------P----SP-QEDGQIMFDVEMHTSRDHSSQSEE---EVVEGE---KEVEAL-KKSADWVSDWSSR C_familiaris_ENSCAFP00000034684 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRASSHCDS----------P----SP-QEDGQIMFDVEMHTSRDHSSQSEE---EAAEGE---KEVDAL-KKSVDWVSDWSSR T_guttata_ENSTGUP00000004349 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRGSSHCDS----------P----SP-QDDGQITFDVEMHTSKDNTSQSEE---EAVEGE---KELEVM-KKSADWVSDWSSR M_domestica_ENSMODP00000027977 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRGSSHCDS----------P----SP-QEDGQIMFDVDMHTSRDHSSQSEE---EAAEGE---KEVEAL-QKSVDWVSDWSSR A_carolinensis_ENSACAP00000006002 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRGSSHCDS----------P----SP-QEDGQIMFDVEMHTSKDNSSQSEE---EPAEGE---KEVDVL-KKSADWVSDWSSR R_norvegicus_ENSRNOP00000055295 GGLEH-PCSASIHSED-MEKILLDTWH-ELGQSS---SRESSHCDS----------P----SA-QEDG-IMFAVEMHTSRDQSYQSEE-----GEGE---KEVEAL-KKIADWVSNCSSR R_norvegicus_ENSRNOP00000049965 GGLEHVSSSSSIHNGD-MEKILLDTQR-ESGQSS---SRGSSHCDS----------P----SR-QEDRQMTFDVEMHSGRDRSSQS-----EAVEGE---KEVEAL-KKSAEWVSDWSSR T_nigroviridis_ENSTNIP00000007933 GGLEHVPSSSSIHNGD-MEKILLDAQH-ES-------SRSNSSCDS----------PPRPHSP-QDEGQLIFNVDVAGRRD--SQSEE---EVLDKE---RDMDIL-MKDSDWVADWSSR X_tropicalis_ENSXETP00000022422 GGLEHVPSSSSIHDGD-MEKILLDAQH-ESGQSS---SRSSSQCDS----------P----SP--EDGQITFDVEMHTSKD-SLQSEE---EAPEEE---KEVDAL-KKSADWVSDWSSR T_rubripes_ENSTRUP00000017630 GGLEHVPSSSSIHNGD-MEKILLDAQH-ES-------SRSNSSCDS----------PPRPHSP-QDEGQLIFHVDVAGRRD--SQSEE---EVVDKE---RDMDIL-MKDADWVADWSSR G_aculeatus_ENSGACP00000024002 GGLEHVPSSSSIHNGD-MEKILLDAQH-ES-------SRSNSSCDS----------PPRPHSP-QDDGQIIFDVDLSGRRD--SLSEE---DGLDKE---RDMDIL-MKDADWVADWSSR G_gallus_ENSGALP00000000309 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRGSSHCDS----------P----SP-QEDGQITFDVEMHTSKDSSSQSEE---EAVEGE---KELEVL-KKSADWVSDWSSR D_rerio_ENSDARP00000038022 GGLEHVPSSSSIHNGD-MEKILLDAQH-ES-------SRSNSSCDS----------PPRPHSP-QDEGQIIFDVD--TRRD----SQE---EVMEKI---RDDDIL-MKDSDRMADWSSR G_aculeatus_ENSGACP00000015037 GGLEHVPSSSSIHNGD-MEKILLDAQH-ES-------SQSSSSCNS----------PHRPPSPDQDEGQITFDVEMPSPRD--SQSED---DSAEKY---REEDILMNKEVDWVADWSSR O_latipes_ENSORLP00000015175 GGLEHVPSSSSIHNGD-MEKILLDAQH-ES-------SPSSSSCDS----------PHRPPSPERDDEQITFDVEMSSLRG--SQSEE---DITEKE---REDDILMNREVDWVTDWSSR D_rerio_ENSDARP00000036535 GGLEHVPSSSSIHNGD-MEKILLDAQH-ES-------SPSSSSCNS----------PPRPHSPDQDEGQIMFDVEMPSERD--CQSED---DSMEKD---KEDDILMNKGESWVADWSSR T_rubripes_ENSTRUP00000001438 GGLEHVPSSSSIHNGD-MEKILLDAQH-ES-------SSSSSSCDS----------PRRPQSPDQDEGQITFDVEMCSPRH--SQSGG---DSPEPS---REDEAPLNKEADWVADWSSR R_norvegicus_ENSRNOP00000041876 WGLEHVPSWPSSHSGD-ME------------QSS---LRGSSHSDC----------S----SP-QEDGQVMFNVEMLTSKDHNSQLEE---EVVEGE---KEVETL-KKSADWVSDWSSR M_domestica_ENSMODP00000024552 --SPVAPASISAYNGD-MEKILLDAQH-ESGRSS---SK-SSHCDS----------PPRSQTP-QDTARMSEADTHSIGEKNSSQSEE---DYMERR---KEVESILKKNSDWIWDWSSR G_gallus_ENSGALP00000017040 TSQEQVPASISIHNGD-MEKILLDAQH-ESGRSS---SRESSHCDS----------PPRSQTP-LDSHRALEIESHSSGEKNSFQSEE---DFLERR---REVERLLKKNADWIWDWSSR P_pygmaeus_ENSPPYP00000003236 ----SVPASVSIYNGD-MEKILLDAQH-ESGRSS---SK-SSHCDS----------PPRSQT---DTNRASETDTHSIGE-NSSQSEE---DDIERR---KEVESILKKNSDWIWDWSSR E_caballus_ENSECAP00000015204 ----SVPASVSIYNGE-MEKILLDAQH-ESGRSS---SK-SSHCDS----------PPRSQTP-QDTNRAFETDTHSIGEKNSSQSEE---DYIERR---KEVESILKKNSDWIWDWSSR G_aculeatus_ENSGACP00000012570 GGQEQIP--TGVPQGD-VEEMLLDAQH-ESGRNS---SKGSSQCNS----------PLRAQTP-LLVWRG--------SEANSSQSDE---DFQERR---REVENMMKKNADWIWDWSSR D_rerio_ENSDARP00000096193 ATDEQ--SASTAPSGD-LEKMLLDAQH-ESGRSS---SRGSLPCDS----------PPRSQTP-LHLCRGSE--VHSSGEKNSSQSEE---DYLERR---KEVEILMKKNADWIWDWSSR O_latipes_ENSORLP00000007433 GQEEQIS--TSSQEGDAVERMLLEAQH-ESGRSS---SRGSSHCNS----------PLRSQTP-LLVWRG--------SEGNSSQSDE---DFQERK---REVENLMKKNADWIWDWSSR H_sapiens_ENSP00000357625 ----SVPASVSIYNGD-MEKILLDAQH-ESGRSS---SK-SSHCDS----------PPRSQTP-QDTNRASETDTHSIGEKNSSQSEE---DDIERR---KEVESILKKNSDWIWDWSSR P_troglodytes_ENSPTRP00000005394 ----SVPASVSIYNGD-MEKILLDAQH-ESGRSS---SK-SSHCDS----------PPRSQTP-QDTNRASETDTHSIGEKNSSQSEE---DDIERR---KEVESILKKNSDWIWDWSSR G_gorilla_ENSGGOP00000014167 ----SVPASVSIYNGD-MEKILLDAQH-ESGRSS---SK-SSHCDS----------PPRSQTP-QDTNRASETDTHSIGEKNSSQSEE---DDIERR---KEVESILKKNSDWIWDWSSR M_mulatta_ENSMMUP00000029538 ----SVPASVSIYNGD-MEKILLDAQH-ESGRSS---SK-SSHCDS----------PPRSQTP-QDTNRASETDTHSIGEKNSSQSEE---DDIERR---KEVESILKKNSDWIWDWSSR R_norvegicus_ENSRNOP00000023477 ----SVPASVSIYNGD-MEKILLDAQH-ESGRSS---SK-SSHCDS----------PPRSQTP-QDTNRA-EIDTHSFGEKNSTLSEE---DYIERR---REVESILKKNSDWIWDWSSR C_familiaris_ENSCAFP00000033658 ----SVPASASIYNGD-LEKILLDAQH-ESGRSS---SK-SSHCDS----------PPRSQTP-QDTTRASEVDTHSIGEKNSSQSEE---DYIERR---KEVESILKKNSDWIWDWSSR M_musculus_ENSMUSP00000101718 ----SVPASVSIYNGD-MEKILLDAQH-ESGRSS---SK-SSHCDS----------PPRSQTP-QDTNRA-EIDSHSFGEKNSTLSEE---DYIERR---REVESILKKNSDWIWDWSSR R_norvegicus_ENSRNOP00000016874 ----SIPASVSIYNGD-MEKILLDAQH-ESGRSS---SK-SSHCDS----------PPRSQTP-QDTNRA-EIDTHSFGEKNSTLSEE---DYIERR---REVESILKKNSDWIWDWSSR X_tropicalis_ENSXETP00000053966 MGQDQGPASISIHNGD-MEKILLDAQH-ESGRSS---SRESSHCDS----------PPRSQTP--SIQRCSESDTSGSKEKSSSQSEE---DYIERR---KELENLLKKNSDWIWDWSSR O_anatinus_ENSOANP00000019225 GGLEHVPSTSYNHNRY-MQNIHLDAAP-EPININ---VPYPPNIDS----------P----SP-QEDGQIMFDVEMHPSRDPSSQSEE---ETIEGE---KDVEVL-KKSVDWVSDWSSR B_taurus_ENSBTAP00000023684 ----SVPDSVSIYNGD-MEKILLDAQH-ESGRSS---SK-SSHCDS----------PPRSQTP-QDTNRASETDTHSLGEKNSSQSEE---DYMERR---KEVESILKKNSDWIWDWSSR O_latipes_ENSORLP00000015347 GGLEHVPSSSSIHNGD-MEKILLDAQH-ES-------SRSNSSCDS----------PPRPHSP-QDEGQIIFDVDMAARRD--SQSEE---EVSDKE---RDMDIL-MKDADWVADWSSR O_cuniculus_ENSOCUP00000002192 ----SVPASVSIYNGD-LEKILLDAQH-ESGRSS---SK-SSHCDS----------PPRSQTP-QDTTRASETDTHSTGEKTSSQSEE---DFIERR---KEVESILKKNSDWIWDWSSR G_gorilla_ENSGGOP00000008208 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRGSSHCDS----------P----SP-QEDGQIMFDVEMHTSRDHSSQXXX---XXXXXX---XXXXXX-XXXXXXXXXXXXX T_nigroviridis_ENSTNIP00000016323 GSQEQIP--TTAQEGD-VEKLLLEAQR-ESGRTS---SRGSSQSNS----------PLRARTP-LLLWRG--------SDGNSSQSDE---DFQERR---CEVENLIKKNADWIWDWSSR T_rubripes_ENSTRUP00000015895 -------------------------------------------------------------------------------------SDE---DFQERR---CEVENLMKRNADWIWDWSSR A_carolinensis_ENSACAP00000007888 ---------------------------------------------S----------PPRSQTP-QDIHRTSEVESRGSGEKNSFQSEE---DFLERR---KEIERLLKKNSDWMWDWSSR T_guttata_ENSTGUP00000011996 ---------------------------------------------------------------------------------------E---DFLERR---REVERLLRKNADWIWDWSSR G_aculeatus_ENSGACP00000021335 GSQE---SISSALQGE-LERILLEAQL-ECERSK----------DS----------PTREGTP-QSTG----------SPRPTSDQDS---DCITIQ---QEEAER-RVDTDWVWDWSSR O_latipes_ENSORLP00000006124 GPQD---SISSALQGE-LERILLEAQL-ECERNK----------DS----------PPQVATP-QSTS----------SPKSTSEHDS---DCVPIQ---NEEAER-RADTEWVWDWSSR T_rubripes_ENSTRUP00000046089 GPED---SITSTLQGE-LERILLEAQV-ECERNR----------DS----------PPQAGTP-QSTG----------SQRPASDQDS---DCVPI----QEEADR-RGDADWVWDWSSR T_nigroviridis_ENSTNIP00000017287 GPED---SISSSLQGE-LERILLEAQL-ECERSR----------ES----------PPQAGTP-QSTG----------SQRPASDQDS---DCVPIQDVIQEEADR-RGDTDWVWDWSSR D_rerio_ENSDARP00000037307 GAQG---TTASVLQGE-LERILLEAQL-ECERSA--------QTDS----------PPQVVTP-RTSG----------SPKPGSEGSSSSTDCVTIQ---SDENDR-RVSAEWVWDWSSR D_rerio_ENSDARP00000032168 ---EDTPALSDIM--D-LEKMLLEAQR-ESSSS----SRTSSHCSSGFCDLFPPPSPRRVQTP--------PLINTAVFNTHTIAQGE---VVLESK---QEAEAVAR-----ISDWSSR A_aegypti_AAEL006711-PA -SPDRTTPLPFTSVEE-YLRLLREAQR-ESKESSRVASLTSSRRDS----------PRG--SP--KSPPNSPNTELATTEEELRGVYI---NYLNRE---GAATSA-QKDTDWVWEWSSR A_gambiae_AGAP001411-PA -SPDRTTPLAFASVEE-YIRLLREAQRDESKESSRVASLTSTRKNS----------PRG--SP--KSPPNSPNTELAATEEDLRNVYI---NYVNKD---G---DI-VKDTDWVWDWSSR 250 260 270 280 290 300 310 320 330 340 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+========= E_caballus_ENSECAP00000004553 PENIPP-KEF-HFRH-PKR--S---------VSLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSH---VL-ALGLGIYIGKRLSTPSA----------ST-Y-------- R_norvegicus_ENSRNOP00000014798 PENIPP-KEF-LFRH-PKR--A---------ASLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSH---VL-ALGLGIYIGKRLSTPSA----------ST-Y-------- B_taurus_ENSBTAP00000033770 PENIPP-KEF-HFRH-PKR--S---------VSLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSH---VL-ALGLGIYIGKRLSTPSA----------ST-Y-------- P_pygmaeus_ENSPPYP00000020684 PENIPP-KEF-HFRH-PKR--S---------VSLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSH---VL-ALGLGIYIGKRLSTPSA----------ST-Y-------- M_musculus_ENSMUSP00000022634 PENIPP-KEF-HFRH-PKR--A---------ASLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSH---VL-ALGLGIYIGKRLSTPSA----------ST-Y-------- M_musculus_ENSMUSP00000099113 PENIPP-KEF-HFRH-PKR--A---------ASLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSH---VL-ALGLGIYIGKRLSTPSA----------ST-Y-------- O_cuniculus_ENSOCUP00000009082 PENIPP-KEF-HFRH-PKR--S---------VSLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSH---VL-ALGLGIYIGKRLSAPCQHLLRGAK-PWTR-V-------- M_mulatta_ENSMMUP00000032171 PENIPP-KEF-HFRH-PKR--S---------VSLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSH---VL-ALGLGIYIGKRLSTPCQHLLRERKSPWKC-V-------- H_sapiens_ENSP00000370003 PENIPP-KEF-HFRH-PKR--S---------VSLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSH---VL-ALGLGIYIGKRLSTPSA----------ST-Y-------- P_troglodytes_ENSPTRP00000034406 PENIPP-KEF-HFRH-PKR--S---------VSLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSH---VL-ALGLGIYIGKRLSTPSA----------ST-Y-------- C_familiaris_ENSCAFP00000034684 PENIPP-KEF-HFRH-PKR--S---------VSLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSH---VL-ALGLGIYIGKRLSTPSA----------ST-Y-------- T_guttata_ENSTGUP00000004349 PENIPP-KEF-HFRH-PKR--S---------VSLSMRKSGAMKKGGIFSAEFLKVFIPSLFISH---VL-ALGLGIYIGKRLTTPSA----------ST-Y-------- M_domestica_ENSMODP00000027977 PENIPP-KEF-HFRH-PKR--S---------VSLSMRKSGAMKKGGIFSAEFLKVFIPSLFISH---VL-ALGLGIYIGKRLSSPSA----------ST-YGRGEPWTC A_carolinensis_ENSACAP00000006002 PENIPP-KEF-HFRH-PKR--A---------VSLSMRKSGAMKKGGIFSAEFLKVFIPSLFISH---VL-ALGLGIYIGKRLTTPSA----------ST-Y-------- R_norvegicus_ENSRNOP00000055295 PENIPC-KEF-HFRH-PKH--A---------MFLSMRESGAMKKRGIFSAEFLKVFILSLFFSH---VLAALGLGIYIGKQLSTHSA----------ST-Y-------- R_norvegicus_ENSRNOP00000049965 PENIPP-KEF-HFRH-PKR--A---------VSLSMRKSGATNKGDIFSVVFLKVFTPSLFLSH---LL-LLGLGIYIKMTEHTFCQHLLRETRAPGNT-C-------- T_nigroviridis_ENSTNIP00000007933 PENIPP-KEF-HFRH-PRR--S---------VMLSMRKTGAMKKGGIFSAEFLKVFIPSLLLSH---IL-ALGLGVYIGKRLTTPPA----------SS-F-------- X_tropicalis_ENSXETP00000022422 PENIPP-KEF-HFHH-PKR--S---------VSLSMRKTGAMKKGGVFSAEFLKVFIPSLFISH---VL-ALGLGIYIGKRLTLSSA----------SS-Y-------- T_rubripes_ENSTRUP00000017630 PENIPP-KEF-NFRH-PRR--S---------VMLSMRKTGAMKKGGIFSAEFLKVFIPSLVLSH---IL-ALGLGVYIGKRLTTPPA----------SS-F-------- G_aculeatus_ENSGACP00000024002 PENIPP-KEF-HFRH-PRR--S---------VTLSMRKTGAMKKGGIFSADFLKVFIPSLLLSH---IL-AVGLGVYIGKRLSAPAA----------SS-F-------- G_gallus_ENSGALP00000000309 PENIPP-KEF-HFRH-PKR--S---------VSLSMRKSGAMKKGGIFSAEFLGFHSISVHIS-----C-FGGLGIYIGKRLTTPSA----------ST-Y-------- D_rerio_ENSDARP00000038022 PENIPP-KEF-HFRH-PRR--S---------VTLSMRKTGAMKKGGIFSAEFLKVFIPSLLLSH---IL-VLGLGVYIGKRLTTPPA----------SS-I-------- G_aculeatus_ENSGACP00000015037 PENVPP-KEF-HFRH-PRR--S---------VSLSMRKTGVMKKGGIFSTEFLKVFIPSLLISH---IL-ALGLGVYIGKRIATAST----------SS-Y-------- O_latipes_ENSORLP00000015175 PENVPP-KEF-HFRH-PRR--S---------VSLSMRKSGVMKRGGIFSSEFLKVFIPSLLISH---IL-ALGIGVYIGKRIATAST----------SS-Y-------- D_rerio_ENSDARP00000036535 PENVPP-KEF-HFRH-PKRSGS---------VSLSMRKSGAMKKGGVFSAEFLKVFMPSLLLTH---IL-ALGIGVYIGKRLSTPPS----------ST-F-------- T_rubripes_ENSTRUP00000001438 PENVPP-KEF-HFRH-PRR--S---------VSLSMRRSGVMKKGGIFSADFLKVLIPSLLISH---LL-ALGLGVYIGKRIAAAPT----------SS-Y-------- R_norvegicus_ENSRNOP00000041876 P-NIPP-KKF-HFRH-PKR--N---------VSLSMRKSGTMKKGVIVFAKFL-LHPFSLPFSQ---V--DFGAGLN-GKEQSTPSA----------ST-Y-------- M_domestica_ENSMODP00000024552 PENVPP-KEF-LFKH-PKR--S---------ATLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSH---FL-AIGLGIYIGRRLTSSAS----------T--F-------- G_gallus_ENSGALP00000017040 PENIPP-KEF-LFKH-PRR--T---------ATLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTTAS----------SSSF-------- P_pygmaeus_ENSPPYP00000003236 PENIPP-KEF-LFKH-PKR--T---------ATLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTSTS----------T--F-------- E_caballus_ENSECAP00000015204 PENVPP-KEF-LFRH-PKR--T---------ATLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTSTS----------T--F-------- G_aculeatus_ENSGACP00000012570 PENNPP-KEF-LLKN-PKR--S---------TSLSIRNTSVMKKGGVLSADFLKLFLPSLIISH---IL-AVGLGIYIGKRLTSHNT-------------Y-------- D_rerio_ENSDARP00000096193 PENLPP-KEF-LLRH-PKR--S---------STLSMRNTSVMKKGGIFSAEFLKVFLPSLVLSH---IL-AVGLGVYIGRRFTASGT-------------F-------- O_latipes_ENSORLP00000007433 PENSPP-KEF-LLKR-PKR--A---------SSLSIRNSSVMKKGGILSADFLKLFLPSLIISH---IL-AVGLGIYIGKRLTSHHT-------------Y-------- H_sapiens_ENSP00000357625 PENIPP-KEF-LFKH-PKR--T---------ATLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTSTS----------T--F-------- P_troglodytes_ENSPTRP00000005394 PENIPP-KEF-LFKH-PKR--T---------ATLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTSTS----------T--F-------- G_gorilla_ENSGGOP00000014167 PENIPP-KEF-LFKH-PKR--T---------ATLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTSTS----------T--F-------- M_mulatta_ENSMMUP00000029538 PENIPP-KEF-LFKH-PKR--T---------ATLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTSTS----------T--F-------- R_norvegicus_ENSRNOP00000023477 PENVPP-KEF-LFKH-PKR--T---------ATLSMRNTSVMKKGGIFSADFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTSTS----------T--F-------- C_familiaris_ENSCAFP00000033658 PENIPP-KEL-LFKH-PKR--T---------ATLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTSTS----------T--F-------- M_musculus_ENSMUSP00000101718 PENIPP-KEF-LFKH-PKR--T---------ATLSMRNTSVMKKGGIFSADFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTSTS----------T--F-------- R_norvegicus_ENSRNOP00000016874 PENVPH-KEF-LFKH-PKR--T---------ATLSMRNTSVMKKGGIFSADFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTSTS----------T--F-------- X_tropicalis_ENSXETP00000053966 PENIPP-KEF-LFKH-PKR--S---------SALSMRNTSVMKKGGIFSAEFLKVFLPSLLLSH---LL-AIGLGVYIGRRLTTSTG----------T--F-------- O_anatinus_ENSOANP00000019225 PENIPP-NLW-YLEAFPGR-AS---------PPLGNDFSRALKEGGHKQGVSCKVMMVVILEEQ---IL-QTGFYIYIGKRLSTPSA----------ST-Y-------- B_taurus_ENSBTAP00000023684 PENVPPAKEFLLFKH-PKR--T---------PTLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTSTS----------T--F-------- O_latipes_ENSORLP00000015347 PENIPP-NLF-EQEK-KER--V---------LSLSMQQLLIASFSVLSSCQ-----TPQLLCKHSFNIF-LSPLSVYIGKRLTTPPT----------SS-F-------- O_cuniculus_ENSOCUP00000002192 PENVPP-KQL-LFRH-PRR--A---------AALSMRNTSVMRKGGVFSADVLKVFLPSLLLSH---LL-AIGL----------------------------------- G_gorilla_ENSGGOP00000008208 XXXXXX-XXX-XXXX-XXX--X---------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XX-XXXXXIYIGKRLSTPSA----------ST-Y-------- T_nigroviridis_ENSTNIP00000016323 PENNPP-KEF-LLKY-PKR--S---------TPLSIRNTSVMKKGGVLSADFLKLFLPSLILSH---IL-AVGLG----------------------DLHR-------- T_rubripes_ENSTRUP00000015895 PENNPP-KEF-LLKH-PKR--A---------TSLSIRNTSVMKKGGVLSADFLKLFLPSLIVSH---IL-AIGLGIFIGRRLTS------------------------- A_carolinensis_ENSACAP00000007888 PENIPP-KEF-LFKH-PKR--T---------SALSMRNTSMMKKGGIFSAEFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTTAS----------SS---------- T_guttata_ENSTGUP00000011996 PENIPP-KEF-LFKH-PRR--T---------ATLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTTAS----------SSTF-------- G_aculeatus_ENSGACP00000021335 PENMPP-KEF-VFQH-PKQ--Q---------SSLSVRKTEVMKR-GIFSSDVFLILVPSLLASH---LL-TLGVGIYIGKRLAASTT----------ST-L-------- O_latipes_ENSORLP00000006124 PENMPP-KEF-VFQH-PKQ--Q---------SSLSVRKTEVMKR-GIFSSDVLLILVPSLLASH---LL-TLGVGIYIGKRLAASTT----------ST-L-------- T_rubripes_ENSTRUP00000046089 PENIPP-KEF-VFQH-PKQ--Q---------RSLSIRKTEVMKR-GLFSSDVLLVLGPSLLASH---LL-TLGVGIYIGKRLAASTS----------ST-L-------- T_nigroviridis_ENSTNIP00000017287 PENIPP-KEF-VFQH-PKQ--Q---------SSLSIRKTEVMKR-GLFSSDVLLVLGPSLLASH---LL-TLGVGIYIGKRLAASST----------ST-L-------- D_rerio_ENSDARP00000037307 PENLPP-KEF-VFHH-PKQ--S---------GSLSVRKTEVMKR-GLFSSDVLLILLPSLLASH---AL-TLGLGIYIGKRLASSST----------ST-L-------- D_rerio_ENSDARP00000032168 PENIPP-TAF-IIKR-PKR--N------------RICNTNTDKDDKEIDRDLLKLLLPSLVLTH---IL-MLGLGICIGRRLSTQCS----------TI---------- A_aegypti_AAEL006711-PA PDQLPP-KDW-KFEH-PKQ--DV----RRMQQGYSMRLTRV-GKNSLFSREVLYSLVLTNVLSL---LL-GAGIGAWLHKRGLLFTR----------ISIE-------- A_gambiae_AGAP001411-PA PDQQPP-KDW-KFEH-PNQ--TQEERNKPIHAGYSIRQVRV-GKNSLFSREFLYSIVLTNVLSL---LL-GAGIGAWLQKRGLLLTR----------VSIE--------