10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_mulatta_ENSMMUP00000001339 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000379625 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000003761 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000001633 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025449 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015673 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000007386 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002088 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000000735 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000018341 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000035092 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009820 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000012280 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000015721 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000020711 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000000429 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000039929 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000044800 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000009551 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000004643 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000001873 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000020077 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007768-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP005252-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0087679 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010636-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP000999-PA ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000045770 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000014020 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000024473 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP001002-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000009600 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL000057-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0084432 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000021907 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010634-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010669-PA MYCVCLTVLLVADTSTGNDCTITNR----------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000008190 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001909 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000018871 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000003444 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000055005 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000020856 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005321 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000036398 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0075360 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000007772 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000363089 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000031395 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000008292 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007619-PA MKVFGSSVKVQPYIRKFVFCNNCHRFGHKEESCKSNKRCGKCSRIHEEVEEQCPNEVKCLHCRKSDHRTTDPNCPSRQREISIKTMMSKKNLTYVEARELIAPLTTQYDVLADIAEFPAL C_familiaris_ENSCAFP00000020672 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000039787 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000004036 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0080080 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000015327 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005325 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010774 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000029040 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000051260 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000015544 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000015503 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000260010 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000003012 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000016910 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000028379 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000093843 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000020834 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP001004-PA ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000029623 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000013025 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007613-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0079369 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000015475 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000007049 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003507-PA ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000015018 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000012269 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000015020 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000010530 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000048303 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028660 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002918 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000013642 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010425 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000007258 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000038393 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000002903 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000026726 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000004627 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000002280 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002290 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000002923 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029702 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000059752 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000279992 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000024401 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010139 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000032224 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000072516 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000027076 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000032922 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000009956 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000016111 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL000633-PA ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000001610 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000004210 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000057557 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP012385-PA ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000000788 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000054706 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000021076 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000091395 ------------------------------------------------------------------------------------------------------------------------ 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_mulatta_ENSMMUP00000001339 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000379625 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000003761 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000001633 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025449 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015673 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000007386 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002088 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000000735 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000018341 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000035092 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009820 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000012280 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000015721 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000020711 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000000429 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000039929 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000044800 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000009551 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000004643 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000001873 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000020077 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007768-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP005252-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0087679 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010636-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP000999-PA ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000045770 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000014020 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000024473 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP001002-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000009600 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL000057-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0084432 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000021907 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010634-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010669-PA ----------------------------------------------------------------------------------------------------------------SRVCWIVE B_taurus_ENSBTAP00000008190 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001909 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000018871 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000003444 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000055005 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000020856 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005321 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000036398 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0075360 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000007772 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000363089 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000031395 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000008292 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007619-PA PNTFAKMTAGRFTMRNNHQQQRNDILTNRSDERPLGAVKKPANSTPVGAKKMRIDDERQQLIKDRNVEGSSKGAGLENRHVVSERESWDNIIRKANADAQETANRNVRGELANFYTALIQ C_familiaris_ENSCAFP00000020672 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000039787 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000004036 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0080080 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000015327 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005325 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010774 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000029040 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000051260 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000015544 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000015503 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000260010 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000003012 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000016910 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000028379 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000093843 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000020834 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP001004-PA -----------------------------------------------------------------------------------------------------------------MKASRGP M_musculus_ENSMUSP00000029623 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000013025 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007613-PA ---------------------------------------------------------------------------------------------------MARALPLLALLLTHNLASSFP D_melanogaster_FBpp0079369 -------------------------------------------------------------------------MEHSKLWDLRPEVRERRFKWTSDGQQQQQQQLGWCNNKDDPPNSHQK D_rerio_ENSDARP00000015475 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000007049 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003507-PA ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000015018 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000012269 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000015020 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000010530 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000048303 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028660 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002918 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000013642 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010425 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000007258 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000038393 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000002903 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000026726 ---------------------------------------------------------------------------------------------------------------------MTN P_pygmaeus_ENSPPYP00000004627 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000002280 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002290 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000002923 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029702 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000059752 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000279992 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000024401 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010139 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000032224 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000072516 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000027076 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000032922 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000009956 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000016111 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL000633-PA ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000001610 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000004210 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000057557 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP012385-PA ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000000788 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000054706 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000021076 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000091395 ------------------------------------------------------------------------------------------------------------------------ 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_mulatta_ENSMMUP00000001339 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000379625 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000003761 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000001633 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025449 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015673 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000007386 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002088 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000000735 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000018341 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000035092 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009820 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000012280 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000015721 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000020711 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000000429 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000039929 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000044800 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000009551 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000004643 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000001873 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000020077 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007768-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP005252-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0087679 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010636-PA ----------------------------------------------------CP-------------------------------------------------------LPVGNQSLVEL A_gambiae_AGAP000999-PA ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000045770 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000014020 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000024473 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP001002-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000009600 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL000057-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0084432 ------------MSRLKAASELALLVIILQLLQWPGSEASFGRDACS----EMSIDGLCQCAPIMSEYEIICPANAENPTFRLTIQPKDYVQIMCNLTDTTDYQQLPKKLRIGEVDRVQM P_pygmaeus_ENSPPYP00000021907 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010634-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010669-PA CPGSNVHLSINVKNRKLNVTCSDKPNFELLRDQPNLRSLTFDQLIYQ----DCP-------------------------------------------------------LPVGYQSLLEL B_taurus_ENSBTAP00000008190 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001909 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000018871 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000003444 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000055005 ---------------------------------------------------------------------------------------------------------------------MRL O_anatinus_ENSOANP00000020856 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005321 ---------------------------------------------------------------------------------------------------------------------MSI P_troglodytes_ENSPTRP00000036398 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0075360 ------------MLATTHMLYVLIATCVIPIFGAALSKTVLYQAPDECRWSGGGEHDITLVCHLRTINS------ELENTNFSVIQPQNTVRLRLECNDALFFQSSLSPDSFRSLVELRD G_gorilla_ENSGGOP00000007772 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000363089 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000031395 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000008292 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007619-PA CPGVTEELQETIKDTHRSIALLVISAIILLVRTQDVTSTSGKRFTCP----EESEAPNCSCEEFPSKTHFYCP--DFNPTLYVDVEDRMRVDFKCY-DEPHDFKSLP-NLAIGSVKLLTV C_familiaris_ENSCAFP00000020672 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000039787 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000004036 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0080080 -----------------MLTYLPVVWLFFALLVLRSATGQIIPLPTF----CLGLSPQCTCAAEGNVVRFHCP--DEYAMLLEVSEPG--ASLYMSYYASTELQWLP-RFNISSLVKIEF C_familiaris_ENSCAFP00000015327 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005325 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010774 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000029040 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000051260 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000015544 ---------------------------------------------------------------------------------------------------------------------MPH A_carolinensis_ENSACAP00000015503 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000260010 ---------------------------------------------------------------------------------------------------------------------MPH G_gorilla_ENSGGOP00000003012 ---------------------------------------------------------------------------------------------------------------------MPH P_pygmaeus_ENSPPYP00000016910 ---------------------------------------------------------------------------------------------------------------------MPH P_troglodytes_ENSPTRP00000028379 ---------------------------------------------------------------------------------------------------------------------MPH M_musculus_ENSMUSP00000093843 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000020834 ---------------------------------------------------------------------------------------------------------------------MPH A_gambiae_AGAP001004-PA RPLVLTAALTLALLAHTGHAFLAGYRSGLGLDGFGICPAEMRNCSCR----SYT----------GAETEIDCP--EADSTVHLRIEPHQYAEMRCQRNRRYDFEQIP-QLSIGDTNRLTI M_musculus_ENSMUSP00000029623 ---------------------------------------------------------------------------------------------------------------------MLR R_norvegicus_ENSRNOP00000013025 ---------------------------------------------------------------------------------------------------------------------MLQ A_aegypti_AAEL007613-PA QHHYTDYVLGGELVSGGGAGGTTTGIGSSGTGGTGTGAGEQRFTCPE----PTTTTSDCTCMYASSDYEIQCP--VINPEITVKIKPGIYAQIQCY--EKQEFSDLP-TLNVGNTTQVKI D_melanogaster_FBpp0079369 SKSNNDARNLNSRVRVRARVRVVPGEMRMGDINCSNGLGNIREDYCEIYLDELGENGTCSIANNEVTTEDYQMKLVFLKLEINWTSPVFHGWNIFKICNETDYELVI-------ISVLGI D_rerio_ENSDARP00000015475 ---------------------------------------------------------------------------------------------------------------------MLV O_anatinus_ENSOANP00000007049 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003507-PA ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000015018 ---------------------------------------------------------------------------------------------------------------------MFN C_familiaris_ENSCAFP00000012269 ---------------------------------------------------------------------------------------------------------------------MSR G_gallus_ENSGALP00000015020 ---------------------------------------------------------------------------------------------------------------------MHT B_taurus_ENSBTAP00000010530 ---------------------------------------------------------------------------------------------------------------------MPR X_tropicalis_ENSXETP00000048303 ---------------------------------------------------------------------------------------------------------------------KYT B_taurus_ENSBTAP00000028660 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002918 ---------------------------------------------------------------------------------------------------------------------MPP G_gorilla_ENSGGOP00000013642 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010425 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000007258 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000038393 ---------------------------------------------------------------------------------------------------------------------LFL M_domestica_ENSMODP00000002903 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000026726 LSEVAAHRKMVHHARTSNALLFVLLFLFPMLLSGRWFPKTLPCDVEAFESTVRVDCSDRRLKEVPRGIPGNATNLTLTINHIPRISPASFTQLENLVEIDFRCNCVPPRLGPKDNVCVTP P_pygmaeus_ENSPPYP00000004627 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000002280 ---------------------------------------------------------------------------------------------------------------------L-- O_anatinus_ENSOANP00000002290 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000002923 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029702 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000059752 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000279992 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000024401 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010139 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000032224 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000072516 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000027076 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000032922 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000009956 -------------------------------------------------------------------------------------------------------------------KCITR P_pygmaeus_ENSPPYP00000016111 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL000633-PA ------------MRPSPALLSVLFGT-IFGVFGASLSKSLLSQAPDECRWSGYSEDDLTLVCRLRTINS------ELENTNFSVLHPENTVRLRLQCNDGLFFQSSISPGSFRQLSELRS G_gallus_ENSGALP00000001610 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000004210 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000057557 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP012385-PA ------------MRPSPALLTVLFGT-IFGVFGASLSKSLVSQAPDECRWDGYTEDDLTLLCRLRTINS------ELENTNFSVLHPENTVRLRLQCNDGLFFQSSLSPGSFKQLTKLHA A_carolinensis_ENSACAP00000000788 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000054706 ---------------------------------------------------------------------------------------------------------------------L-- P_troglodytes_ENSPTRP00000021076 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000091395 ------------------------------------------------------------------------------------------------------------------------ 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_mulatta_ENSMMUP00000001339 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000379625 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000003761 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000001633 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025449 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015673 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000007386 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002088 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000000735 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000018341 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000035092 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009820 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000012280 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000015721 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000020711 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000000429 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000039929 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000044800 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000009551 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000004643 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000001873 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000020077 -------------------------------------------------------------------------------------------------------------MSAPLSLQDQE A_aegypti_AAEL007768-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP005252-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0087679 -------------------------------------------------------------------------------------------------------------MRPRFVCHQQH A_gambiae_AGAP010636-PA LSVFLNR----------TQLSSIR---------------------------SIAFDDNAKHSNKVTLDPHLF-SGLQNLQ----------------LLKINNL-TTNAFDNPHLFKHFLH A_gambiae_AGAP000999-PA ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000045770 ----------MMPPWLLARTLIMA-------------------------------------------------L-FFSCL----------------TPGSLN-PCIEVVPNITYQCMDQK R_norvegicus_ENSRNOP00000014020 ----------MMPLLHLAGTLIMA-------------------------------------------------L-FLSCL----------------RPGSLN-PCIEVLPNITYQCMDQN M_domestica_ENSMODP00000024473 ----------MVPW--MVMALIMA-------------------------------------------------TTFFSCP----------------DPGSCH-SCLEVFPSIEYQCMDQN A_gambiae_AGAP001002-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000009600 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL000057-PA ----------------------------------------------------------------MDLSDNYF-QGFRDLT----------------TLRLDFG-IENL--PTSLFKELTM D_melanogaster_FBpp0084432 RRCMLPGHTPIASILDYLGIVSPT---------------------------TLIFES---DNLGMNITRQHL-DRLHGLK----------------RFRFTTRRLTHI--PANLLTDMRN P_pygmaeus_ENSPPYP00000021907 ----------MMSASRLAGTLIPA-------------------------------------------------MAFLSCV----------------RPESWE-PCVEVVPNITYQCMELN A_gambiae_AGAP010634-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010669-PA LSAFLDH----------TQLSYIV---------------------------ELILINNADLSANVTLDPPLF-AGLHKLQ----------------TLVIDNY-AV-SFDKP------LP B_taurus_ENSBTAP00000008190 ----------MMARARLAAALIPA-------------------------------------------------TAILSCL----------------RTESWD-PCVQVVPNISYQCMELN O_cuniculus_ENSOCUP00000001909 ----------MMPRLRLAGTLVPA-------------------------------------------------MAFLSYL----------------RPEIWE-PCVEVVPNITYQCMEKN M_domestica_ENSMODP00000018871 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000003444 ----------------------------------------------------------------------------------------------------WDLPLLQVTPNTTFRCTGLN D_rerio_ENSDARP00000055005 ----------------VGTMTAII-------------------------------------------------LIMFILA----------------QGLECSQTCKCD-QMYFCNCSSNN O_anatinus_ENSOANP00000020856 ---------------------------------------------------------------------------------------------------------LQVVANITYQCMELD T_guttata_ENSTGUP00000005321 Q---AKHKSRMTNTWRVLAIYVIL-------------------------------------------------AASLSEQ----------------QALKQ-ACPSCD-GSQLCNCSSMG P_troglodytes_ENSPTRP00000036398 ----------MMSASRLAGTLIPA-------------------------------------------------MAFLSCV----------------RPESWE-PCVEVVPNITYQCMELN D_melanogaster_FBpp0075360 LTIEYCKLGNLTDG-SFRGLQELR-------------------------NLTIRTHNGDWSTMSLEMASNSF-VEFRQLE----------------RLDLSLNNIWLI--PDGMVCPLKS G_gorilla_ENSGGOP00000007772 -----------------------------------------------------------------------------------------------------------VVPNITYQCMELN H_sapiens_ENSP00000363089 ----------MMSASRLAGTLIPA-------------------------------------------------MAFLSCV----------------RPESWE-PCVEVVPNITYQCMELN C_familiaris_ENSCAFP00000031395 ----------MMSPTRLVGILIPA-------------------------------------------------MAFLSCL----------------RPESWD-PCMQVVANTTYQCMELN E_caballus_ENSECAP00000008292 ----------MMPPTRLAGTLIPA-------------------------------------------------MAFLSCL----------------RPESWD-PCVQVVPNTTYQCMDLN A_aegypti_AAEL007619-PA VDCALDEDRPILESFKFLEVANVR---------------------------SFVYNN---HENGIHYNARYF-EGLEQLE----------------NLTLARG-VVSI--DKDTFSGFLN C_familiaris_ENSCAFP00000020672 ----------------------------------------------------------------------------------------------------------------LGLS---- M_mulatta_ENSMMUP00000039787 ----------MTSALRLAGTLIPA-------------------------------------------------MAFLSCV----------------RPESWE-PCVEVVPNITYQCMELK E_caballus_ENSECAP00000004036 ------------------------------------------------------------------------------------------------------------MSHRMGLL---- D_melanogaster_FBpp0080080 DAYIFWPEKFLSDLLKTLGVQTVK---------------------------TIIFRDRTLETVVTRDVLNSG-NGY-----------------------METSQPENI--TTWHFGSVPG C_familiaris_ENSCAFP00000015327 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005325 ---------------------------------------------------------------------------------------------------------SCD-GSQLCNCSSMG O_cuniculus_ENSOCUP00000010774 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000029040 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000051260 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000015544 ------------ALWTVWVLGAVI-------------------------------------------------S--LSKE----------------GVPDQPSSLSCD-PTGVCDGRSRS A_carolinensis_ENSACAP00000015503 ---------------------------------------------------------------------------------------------------------------------SKA H_sapiens_ENSP00000260010 ------------TLWMVWVLGVII-------------------------------------------------S--LSKE----------------ESSNQ-ASLSCD-RNGICKGSSGS G_gorilla_ENSGGOP00000003012 ------------TLWMVWVLGVII-------------------------------------------------S--LSKE----------------ESSNQ-ASLSCD-RNGICKGSSGS P_pygmaeus_ENSPPYP00000016910 ------------TLWMVWVLGVII-------------------------------------------------S--LSKE----------------ESSSQ--ALSCD-RNGICKGSSGS P_troglodytes_ENSPTRP00000028379 ------------TLWMVWVLGVII-------------------------------------------------S--LSKE----------------ESSNQ-ASLSCD-RNGICKGSSGS M_musculus_ENSMUSP00000093843 ----------------------------------------------------------------------------------------------------------------MGLL---- M_mulatta_ENSMMUP00000020834 ------------TLWMVWVLGVII-------------------------------------------------S--LSKE----------------ESSNQ-ASLSCD-HNGICKGSSGS A_gambiae_AGAP001004-PA DDCPFPHHQSILQLVSFLGTTQVK---------------------------VLWLKNNANHEQSASLVRHHF-AGLDQLD----------------RLAISNAKLSDI--GPDLFEHLPN M_musculus_ENSMUSP00000029623 ------------ALWLFWILVAIT-------------------------------------------------V--LFSK----------------RCSAQ-ESLSCD-ASGVCDGRSRS R_norvegicus_ENSRNOP00000013025 ------------ALWLFWILMAVI-------------------------------------------------G--LSRE----------------GHSAQ-ASLSCD-AAGVCDGSSRS A_aegypti_AAEL007613-PA IHCPLPQRQSIKQFIKFLGVNHVK---------------------------DFWYQNYG-KDFGVRLIRQHF-EGMHDLE----------------KLFLSSG-IEDI--QPDLFADLPN D_melanogaster_FBpp0079369 RSEVDMRISPAVQYLSLLGIREISGYDIYLPSVLITEMDVHHANGPKMVTFKYLYDSTVNSVITNNYIRKTM-NNTEKIK----------------IYYHNTFEKTTLTMEKNIFHGKNK D_rerio_ENSDARP00000015475 P---------------LVLILSLQ-------------------------------------------------AVLHIKH----------------AKAKQSCTIAF--DKLSADCKGLR O_anatinus_ENSOANP00000007049 ----------------------------------------------------------------------------------------------------------------MGIR---- A_aegypti_AAEL003507-PA ---------------------------------------------------------------------------MQGLE----------------KLFLSAG-IDYI--QQDLFADLRN G_gallus_ENSGALP00000015018 Q---SKQKPTMKLMWQAWLIYTAL-------------------------------------------------AAHLPEE----------------QALRQ-ACLSCD-ATQSCNCSFMG C_familiaris_ENSCAFP00000012269 ------------VLWTLWVLGAVT-------------------------------------------------N--LSKE----------------EAPDQSSSLSCD-PTGVCDGRSRS G_gallus_ENSGALP00000015020 --------------WKMWAICTAL-------------------------------------------------AAYLPEE----------------QALRQ-ACLSCD-ATQSCNCSFMG B_taurus_ENSBTAP00000010530 ------------ALWTAWVW-AVI-------------------------------------------------I--LSTE----------------GASDQASSLSCD-PTGVCDGHSRS X_tropicalis_ENSXETP00000048303 E-----KECSGHTISCTPILYC------------------------------------------------------LRET----------------LWHPLTICINTNIQRRYANCQGQD B_taurus_ENSBTAP00000028660 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002918 ------------ALWTVWALGAIV-------------------------------------------------S--LPTE----------------GAPDL-PSLSCD-PAGICDGRSRS G_gorilla_ENSGGOP00000013642 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010425 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000007258 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000038393 SGLEDVKNMEMFRRYNEPVFYCFL-------------------------------------------------LLALTKG----------------IWSQNSCQVDE--KQKYANCQGQN M_domestica_ENSMODP00000002903 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000026726 PSIENGSFAALTRLKSLYLDANQL--------------------SKIPRGLPATLRLLSLEANNIFSIKKNTFSELRNIELLYLGQNCYYRNPCNVSFEIEETAFLNLKNLTVLSLKSNN P_pygmaeus_ENSPPYP00000004627 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000002280 --------------------------------------------------------------------------------------------------------------GRAADCTGGQ O_anatinus_ENSOANP00000002290 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000002923 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029702 ----------------------------------------------------------------------------------------------------------------MTLL---- P_troglodytes_ENSPTRP00000059752 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000279992 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000024401 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010139 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000032224 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000072516 ----------------------------------------------------------------------------------------------------------------MTLL---- P_troglodytes_ENSPTRP00000027076 ----------------------------------------------------------------------------------------------------------------MTLL---- X_tropicalis_ENSXETP00000032922 ------------------------------------------------------------------------------------------------------------LVMPILILSYVI X_tropicalis_ENSXETP00000009956 RNCWGQKKECWSNTCPIAALMTLI-------------------------------------------------LQPISFI----------------ECYGYRKCSLEGIHTEYANCVGQS P_pygmaeus_ENSPPYP00000016111 ----------------------------------------------------------------------------------------------------------------MTLL---- A_aegypti_AAEL000633-PA LSIEYCKIANLSDG-SFRGLKELM-------------------------NLTLRTHNTDWSSVSLEIAPHVFNSELSKLE----------------QLDLSQNNMWSI--PDGMICPLTK G_gallus_ENSGALP00000001610 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000004210 ----------------------------------------------------------------------------------------------------------------MRLL---- X_tropicalis_ENSXETP00000057557 ------------KKCIFYIYICVY-------------------------------------------------MHVFSKT----------------THNKVHN------KEGILNMLWHL A_gambiae_AGAP012385-PA LSIEYCKIANLSEG-SFQGLKQLV-------------------------NLTLRTHNTDWSSISLDIAPQVFTSELAKLQ----------------RLDLSQNNMWSV--PDGFICPLAR A_carolinensis_ENSACAP00000000788 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000054706 --------------------------------------------------------------------------------------------------------VDE--SRRFVSCSGRN P_troglodytes_ENSPTRP00000021076 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000091395 ------------------------------------------------------------------------------------------------------------------------ 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_mulatta_ENSMMUP00000001339 ------------------------------------------------------------------------------------------MAAGGPGTEPAAPVSSTS-SLPLAALNMRV H_sapiens_ENSP00000379625 ------------------------------------------------------------------------------------------MAAGGPGAGSAAPVSSTS-SLPLAALNMRV G_gorilla_ENSGGOP00000003761 ------------------------------------------------------------------------------------------MAAGGPGAGSAAPVSSTS-SLPLAALNMRV E_caballus_ENSECAP00000001633 ------------------------------------------------------------------------------------------MAAGGPGVGSAPHIPSAS-SLPLAALNVRV P_troglodytes_ENSPTRP00000025449 ------------------------------------------------------------------------------------------MAAGGPAAGSAAPISSTS-SLPLAALNMRV P_pygmaeus_ENSPPYP00000015673 -----------------------------------------------------------------------------MRPDRAEAPGQTAMAAGGPGAGSAAPVSSTS-SLPLAALNMRV C_familiaris_ENSCAFP00000007386 ------------------------------------------------------------------------------TRRRRCGPRRPAMAAEGSRAGSASPVCPKA-SLPLAALNVRV O_cuniculus_ENSOCUP00000002088 ------------------------------------------------------------------------------------------MAAGGPDLSSEPPARSAS-SLPLAALNVRV B_taurus_ENSBTAP00000000735 ------------------------------------------------------------------------------------------MAEGVPRAGSALPAASLS-SLPLAALNVRV R_norvegicus_ENSRNOP00000018341 ------------------------------------------------------------------------------------------MSAGGPRVGSVSVDSYLF-SLPLVALNVGV M_musculus_ENSMUSP00000035092 ------------------------------------------------------------------------------------------MSAGDPRVGSGSLDSFMF-SIPLVALNVGV A_carolinensis_ENSACAP00000009820 ---------------------------------------------------------------------------------------------------------------PLVALNYAL O_latipes_ENSORLP00000012280 -------------------------------------------------------------------------------------------------MAGCSSDVDLW-TVPLVALNVTV T_nigroviridis_ENSTNIP00000015721 -------------------------------------------------------------------------------------------------MACCESKTDLF-KIPLVALNMSF D_rerio_ENSDARP00000020711 --------------------------------------------------------------------------------------------------MASKLSIDHE-AIPVTALNCSF T_guttata_ENSTGUP00000000429 ---------------------------------------------------------------------------------------MATAPSQPAASPGPGPLPDLQ-AVPMVALNYGV X_tropicalis_ENSXETP00000039929 -----------------------------------------------------------------------------------------------MACGSSLRSVDMN-SIPLVALNYNV T_rubripes_ENSTRUP00000044800 ------------------------------------------------------------------------------------------VSTRHVCAASGDVTSALS-RVPLLALNMGF G_gallus_ENSGALP00000009551 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000004643 -------------------------------------------------------------------------------------------------MACVDSEVDLW-VVPLVALNMSV O_anatinus_ENSOANP00000001873 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000020077 KEFNKLAHEQERARLESGESLHGGCDKLAAELDKKPENEGACGGASCLFPPPSYMQQSHASADPNPLGEI---------------SAKEDERNNVISYAVGMPRSDFC-STKLRHLRFDS A_aegypti_AAEL007768-PA ------------------------------------------------------------------------------------------MVNSTPVEVSLNECVDLS-KVPLGALNYKT A_gambiae_AGAP005252-PA -------------------------------------------------------------------------------------MLDNPVK---PTEVSVKNRIDLA-VVPLEALSSRT D_melanogaster_FBpp0087679 SVAHS------------------------------HYQPHSHFHHHTHRHPNPPHHHHIYGATDVSYRRYRTAGM----------VVAEGVMDSGSGSGTGTGLGHFN-ETPLSALGIET A_gambiae_AGAP010636-PA LNNLI--ITSNKCIPGKCSHQLKQL----------E---TFSIEDSEISIIPIELVSNLTHLQSLSFRNN---------------SLKQ-VE--RFAMLSSLTHLNFG-YNQLVSLHNDV A_gambiae_AGAP000999-PA ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000045770 LSKVP---DDIP-----------------------SSTKNIDLSFNPLKILKSYSFSNFSELQWLDLSRC---------------EIET-IEDKAWHGLHHLSNLILT-GNPIQSFSPGS R_norvegicus_ENSRNOP00000014020 LSKIP---HDIP-----------------------YSTKNLDLSFNPLKILRSYSFSNFSQLQWLDLSRC---------------EIET-IEDKAWHGLNQLSTLVLT-GNPIKSFSPGS M_domestica_ENSMODP00000024473 FSKVP---MDIP-----------------------ASTQKLDLSFNPLRSLAPRSFSRITELRILDLSRC---------------DIQK-IEDDTYEGLHNLSTLILT-GNPIQSLGIRA A_gambiae_AGAP001002-PA -------------------------------------------------TLPTELITDLPSLGSLTLYHN---------------MLER-IE--QFADLPNLTSLDLT-YNELDTLQEDV T_guttata_ENSTGUP00000009600 ----------------------------------------------AAERCDDWGVDTMKQIQIYDGEPA---------------KIKCPLFETFLK-----YNYSTA-HSAGLTLIWYR A_aegypti_AAEL000057-PA LERLT--LTAQL--KKLPIDLLINQ----------NQLVELILKNNRIEEIPFDFFRHQNNLIHLDLSAN---------------RLQS-IAEITFANLTSLIHLDMS-HNAIQSVHANA D_melanogaster_FBpp0084432 LSHLE--LRANI--EEMPSHLFDDL----------ENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSN---------------QLHN-LTKHDFEGATSVLGIDIH-DNGIEQLPHDV P_pygmaeus_ENSPPYP00000021907 FYKIP---DNLP-----------------------FSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRC---------------EIQT-IEDGAYQSLSHLSTLILT-GNPIQNLALGA A_gambiae_AGAP010634-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010669-PA LQQLP--SGVNR-FSGSILHQLQQK----------QHRHSIAEGDWEMNIMPSGLVSIVPNLQMLTLHRH---------------NFKQ-IE--HFAKLPSLTYFNIS-SNQLMSLHDDM B_taurus_ENSBTAP00000008190 LYKIP---DNIP-----------------------ISTKMLDLSFNYLRHLGSHNFSSFPELQVLDLSRC---------------EIKI-IEDDTFQGLNHLSTLILT-GNPIQSLAWGA O_cuniculus_ENSOCUP00000001909 LYKIP---DNIP-----------------------FSTKNLDLSFNLLEHLGSHSFLHVSELHFLDLSRC---------------KIHT-IEDDAYQGLKNLSPLILT--NPIQSLSPQA M_domestica_ENSMODP00000018871 -----------------------------------------------SERCDDWGLDPMRQIQVYEGEPA---------------HIQCPLFEHFLK-----FNYSTA-HSAGLTLIWYW T_guttata_ENSTGUP00000003444 ISGVP---DGVP-----------------------NTTQNLDLSFSNLKSLGSNYFASVPELQILDLSRC---------------HLHT-IEDNSFMDLPRLSTLVLT-ANSLQHLGKAA D_rerio_ENSDARP00000055005 LHQVP---T-VP-----------------------SDVLGLDLSFNQIESINMTDLSSYNELIILNLHKN---------------KLRH-IHRDAFKSQHNLEVLDLS-LNNLNNLSPSW O_anatinus_ENSOANP00000020856 LSEVP---AEIP-----------------------SSAQNLDLSFNPLGTLVPKGFSMLPDLRMLDLTRC---------------QIQV-IEDDAFRGLCNLSTLILT-GNPVQRLGASA T_guttata_ENSTGUP00000005321 LDFIP---PGVT-----------------------AIITVLNLAHNGIKRIQSQDLQQAVNLRALLLQSN---------------KISS-IDEDSFWSLEKLELLDLS-NNSLAHLSPVW P_troglodytes_ENSPTRP00000036398 FYKIP---DNLP-----------------------FSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRC---------------EIQT-IEDGAYQSLSHLSTLILT-GNPIQSLALGA D_melanogaster_FBpp0075360 LQHLN--ASYNK-IQDISNFYFSASLSSRKARVCGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKN---------------SMSF-LADRAFEGLLSLRVVDLS-ANRLTSLPPEL G_gorilla_ENSGGOP00000007772 FYKIP---DNLP-----------------------FSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRC---------------EIQT-IEDGAYQSLSHLSTLILT-GNPIQSLALGA H_sapiens_ENSP00000363089 FYKIP---DNLP-----------------------FSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRC---------------EIQT-IEDGAYQSLSHLSTLILT-GNPIQSLALGA C_familiaris_ENSCAFP00000031395 LSKIP---NNIP-----------------------TSTEKLDLSFNPLRHLGSHCFSNFPKLQVLDLSRC---------------EIQV-IEDDAYQGLNHLSILILT-GNPIQRLFPRA E_caballus_ENSECAP00000008292 LYKIP---ENIP-----------------------TSTKELDLSFNPLKELGSHSFSNFPELQVLDLSRC---------------EIEM-IEDDAYQGLNHLSTLILT-GNPIRSLALGA A_aegypti_AAEL007619-PA LKRLT--IEHNK--LNLQPGTFEAL----------SNLTYLGLVYNGIDEIQPGLFDGLESLEALSLSYN---------------DIKS-LSAGSFNGLSSLRMLNLR-VNKIESFDANT C_familiaris_ENSCAFP00000020672 -SYVM------------------------------KRKFYLLLLSAATKRCDDWGLDTMRQIQVFEDEPA---------------RIKCPLFEHFLK-----YNYSTA-HSAGLTLIWYW M_mulatta_ENSMMUP00000039787 FYKIP---DNIP-----------------------FSTKNLDLSFNPLRHLGSYSFLRFPELQVLDLSRC---------------EIQT-IEDGAYQSLSHLSTLILT-GNPIQSLALGA E_caballus_ENSECAP00000004036 -WCVM------------------------------SLYFYGILQSHASERCDDWGLDTMRQIQVFEDEPA---------------RIKCPLFEHFLK-----YNYSTA-HSAGLTLIWYW D_melanogaster_FBpp0080080 LKKFK--FFSHV--PELQESIFHGF----------DTLRDLHLSVN-----------------VTTLPGN---------------MLST-VN-------GTLKTLTIE-SPGIVSFGNPL C_familiaris_ENSCAFP00000015327 -----------------------------------------------------------------------------------------------MASSTSFPAPRSRSRKPVGKVADWF T_guttata_ENSTGUP00000005325 LDFIP---PGVT-----------------------AKITVLNLAHNRIKRIQSQDLQQAVNLRALLLQSN---------------KISS-IDEDSFWSLEKLELLDLS-NNSLAHLSPVW O_cuniculus_ENSOCUP00000010774 -----------------------------------------------------------------------------------------------MASSTSLPAPRSRPKKPLGKMADWF O_anatinus_ENSOANP00000029040 --------------------------------------QQLDLSKNSIRHVGKTDLQNCVNLKALMLQAN---------------QIGT-IDEDAFLSLGILELLDLS-KNRLSSLSPSW R_norvegicus_ENSRNOP00000051260 ------------------------------------------------ERCDDWGLDTMRQIQVFEDEPA---------------RIKCPLFEHFLK-----YNYSTA-HSSGLTLIWYW E_caballus_ENSECAP00000015544 LNSIP---SGLT-----------------------AAVKSLDLSNNKIASVGNSDLWKCVNLKALRLGSN---------------DINT-IEEDSFSSLRSLEHLDLS-NNHLSNLSSSW A_carolinensis_ENSACAP00000015503 FSMVP---PDLT-----------------------GNVLRLDLSFNRIEQVREADLKSAVNLRMLLLQSN---------------LIQT-IEEDAFHTLTRLEHLDLS-RNKLTHLSSSW H_sapiens_ENSP00000260010 LNSIP---SGLT-----------------------EAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSN---------------GINT-IEEDSFSSLGSLEHLDLS-YNYLSNLSSSW G_gorilla_ENSGGOP00000003012 LNSIP---SGLT-----------------------EAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSN---------------GINT-IEEDSFSSLGSLEHLDLS-YNYLSNLSSSW P_pygmaeus_ENSPPYP00000016910 LNSIP---SGLT-----------------------EAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSN---------------GINT-IEEDSFSSLGSLEHLDLS-YNYLSNLSSSW P_troglodytes_ENSPTRP00000028379 LNSIP---SGLT-----------------------EAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSN---------------GINT-IEEDSFSSLGSLEHLDLS-YNYLSNLSSSW M_musculus_ENSMUSP00000093843 -WYLM------------------------------SLSFYGILQSHASERCDDWGLDTMRQIQVFEDEPA---------------RIKCPLFEHFLK-----YNYSTA-HSSGLTLIWYW M_mulatta_ENSMMUP00000020834 LNSIP---SVLT-----------------------EAVKCLDLSNNRITYISNSDLQRYVNLQALVLTSN---------------GINT-IEEDSFSSLGRLEHLDLS-YNYLSNLSSSW A_gambiae_AGAP001004-PA LTWLD--MRDNI--FRLPATIFDAL----------PKLRVLELSFNSLEELDPRLLRHLPNLRLLTLWHN---------------KLRT-LSRAAFAGVPELERLDLS-SNQLESVPGDL M_musculus_ENSMUSP00000029623 FTSIP---SGLT-----------------------AAMKSLDLSFNKITYIGHGDLRACANLQVLMLKSS---------------RINT-IEGDAFYSLGSLEHLDLS-DNHLSSLSSSW R_norvegicus_ENSRNOP00000013025 FTSIP---SGLT-----------------------ANTKKLDLSFNKITYIGHGDLRACVNLRVLTLESS---------------GINT-IEGDAFYSLGSLEHLDLS-NNHLSSLSSSW A_aegypti_AAEL007613-PA LKWLI--LRSNH--VKLLHNVFDNL----------TNLIILELGANQITELEPGLFKNQRKLRHLNLWRN---------------QLRN-ISKESFRGAETLQELDLS-VNAIETLNSDV D_melanogaster_FBpp0079369 MSALI--FNGLK-IKGLTNNTFENL----------TSLNTLIFDNVFLKDL--SFLRSSTLQSSLTYCIM---------------KVDNMVDLKSFEKFTNLEIIEVSQYKGFKNFTAFI D_rerio_ENSDARP00000015475 LDSVP--TTQLP-----------------------DSLEELDLSFNTIHVIRKQDFVKLTYLRVLKLNFN---------------NISL-VLDDAFQGNLLLEELNLF-NNSLTEIPFKA O_anatinus_ENSOANP00000007049 -WKLT------------------------------NIVSYFSLM--VQERCEDWGLDTMTKIQVYDGEPA---------------CIKCPLFEQFLK-----YNYSTA-HSAGLTLIWYW A_aegypti_AAEL003507-PA LKWLV--LQGNN--LTRLGNVFDSL----------IDLVILELGANQISDLQAGFLQKQSKLRHLNLWHN---------------EIRK-VSKDMFRGAESLEELDLS-VNLIKYLEPDV G_gallus_ENSGALP00000015018 LDFIP---PGLT-----------------------GKITVLNLAHNRIKLIRTHDLQKAVNLRTLLLQSN---------------QISS-IDEDSFGSQGKLELLDLS-NNSLAHLSPVW C_familiaris_ENSCAFP00000012269 LNSMP---SGLT-----------------------AAVRSLDLSNNEITYIGNSDLRDCVNLKALRLESN---------------GINT-IEEESFFSLWSLEHLDLS-YNLLSNLSSSW G_gallus_ENSGALP00000015020 LDFIP---PGLT-----------------------GKITVLNLAHNRIKVIRTHDLQKAVNLRTLLLQSN---------------QISS-IDEDSFGSQGKLELLDLS-NNSLAHLSPVW B_taurus_ENSBTAP00000010530 LNSIP---SGLT-----------------------AGVKSLDLSNNEITYVGNRDLQRCVNLKTLRLGAN---------------EIHT-VEEDSFFHLRNLEYLDLS-YNRLSNLSSSW X_tropicalis_ENSXETP00000048303 LVEVP---QDLP-----------------------VTLQSLDLSYNRLFHIRYEDFSSYTNLRALNLSFN---------------NIST-IECGSFASNTLLRNLTLF-NNSLTEMPSTL B_taurus_ENSBTAP00000028660 -----------------------------------------------------------------------------------------------MASSTSSPAPGSRSKKPLGKMADWF O_cuniculus_ENSOCUP00000002918 FQSIP---SGLM-----------------------ATVKSLDLSNNEITYIRDSDLHRCVHLRALMLMSN---------------GIDT-IDEDSFSSLGSLEHLDLS-NNHLSHLSAAW G_gorilla_ENSGGOP00000013642 -----------------------------------------------------------------------------------------------MASSTSLPAPGSRPKKPLGKMADWF M_mulatta_ENSMMUP00000010425 -----------------------------------------------------------------------------------------------MASSTSLPAPGSRPKKPLGKMADWF A_carolinensis_ENSACAP00000007258 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000038393 LNDVP---KDLP-----------------------VTLEVLDLSCNWISQIRVDDFSSYTNLQALNLSFN---------------NIST-IDNSSFASNTQLRNLTLF-NNGLTEMPSTL M_domestica_ENSMODP00000002903 -----------------------------------------------LYSSWEEECVERSFITALEGEPF------------------------------HLKCCLSA-RRHHKNKTFTW G_gallus_ENSGALP00000026726 LTFIP---PNLS-----------------------STLKELYIYNNRIQEVQEHDLSNLYNLEILDLSGNCPRCYNAPYPCTPCPNISIKIHSKAFYSLKKLRILRLH-SNSLQSIPSSW P_pygmaeus_ENSPPYP00000004627 -----------------------------------------------------------------------------------------------MASSTSLPAPGSRPKKPLGKMADWF G_aculeatus_ENSGACP00000002280 LERVP--WRQFP-----------------------STLEDLDLSFNELQAVHADDFHHLAQLRVLKLQYN---------------NISH-IDSEAFKNNGLLEHLDVF-NNSLAEIPASA O_anatinus_ENSOANP00000002290 ------------------------------------TTVRLLLAFNHIRTVNATSFPLLEKLELLELGNQ---------------TAALTIHRDAFRNLPNLKVLDLG-YNPKLFLDPDA M_domestica_ENSMODP00000002923 ----------------------------MFSLHHIFLWLVIRAGVKGDSELSGCPTKSSWRYLARSGEKF---------------FLFCDVPRRGRISKKDICGKTRC-HDISCSSDVRW M_mulatta_ENSMMUP00000029702 -WCVV------------------------------SLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPA---------------RIKCPLFEHFLK-----FNYSTA-HSAGLTLIWYW P_troglodytes_ENSPTRP00000059752 -----------------------------------------------------------------------------------------------MASSTSLPAPGSRPKKPLGKMADWF H_sapiens_ENSP00000279992 -----------------------------------------------------------------------------------------------MASSTSLPAPGSRPKKPLGKMADWF C_intestinalis_ENSCINP00000024401 -----------------------------------------------------------------------------------------------MECDCSMQSLSLW---YIQAETTYH E_caballus_ENSECAP00000010139 -----------------------------------------------------------------------------------------------MASSSSFPAPRSRSRKPLGKMADWF R_norvegicus_ENSRNOP00000032224 -----------------------------------------------------------------------------------------------MASSSSVPASSTQSKKPRDKIADWF H_sapiens_ENSP00000072516 -WCVV------------------------------SLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPA---------------RIKCPLFEHFLK-----FNYSTA-HSAGLTLIWYW P_troglodytes_ENSPTRP00000027076 -WCVV------------------------------SLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPA---------------RIKCPLFEHFLK-----FNYSTA-HSAGLTLIWYW X_tropicalis_ENSXETP00000032922 CSCVT------------------------------KSIKTLGWFCSSLERCDDWGVDTMKLIQAYEGEPA---------------RIRCPLFQDFLK-----HNYSTA-HSAGLTLMWYW X_tropicalis_ENSXETP00000009956 VVTLADAIQDLP-----------------------YQTRVLNISENEISKIDGYTFSHLPKLQELVLRKN---------------KVNG-VDTWAFHNLNDLLILDLS-YNLIQSLDTVD P_pygmaeus_ENSPPYP00000016111 -WCVV------------------------------SLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPA---------------RIKCPLFEHFLK-----FNYSTA-HSAGLTLIWYW A_aegypti_AAEL000633-PA LQYLN--LTQNR-LRDLSVFHFSASLSTRLSKKCGGSITILDLSHNNIDNLPPAIFSGLGKLTELRLQNN---------------GLNF-IADRALEGLLSLSKLDIS-LNRLSNLPPEL G_gallus_ENSGALP00000001610 --------------------------------------------------------------------------------------------------------------------AGWF O_cuniculus_ENSOCUP00000004210 -WCVM------------------------------SLYFYGIPQSDASERCDDWGLDTMRQIQVFEDEPA---------------RIKCPLFEHFLK-----FNYXXX-XXXXXXXXXXX X_tropicalis_ENSXETP00000057557 KKK-----KKIH-----------------------IHTYIYDFTKENITHLKTSDFNCFLQLRLLNLSHN---------------LIGE-LDCSVFKFNPSLEYLDIS-NNRLHTIKCHS A_gambiae_AGAP012385-PA LSYIN--LTQNR-LRDLSVFHFSASLSTRLSKKCGSSIVTLDLSHNTIDNLPPAIFSGLGKLTDLRLQSN---------------GLNY-IADRAFEGLVSLSRLELS-LNRLTNLPPEL A_carolinensis_ENSACAP00000000788 -----------------------------------------------AERCDDWGVDTMKHKPVYNGEPA---------------RIKCPLFEAFLK-----YNYSTA-HSAGLTLIWYW X_tropicalis_ENSXETP00000054706 LVEIP---KNFS-----------------------VTLEELDMSFNRIFQIKSDDFSAYTNLRALNLSYN---------------QIAT-IENGSFNSNTQLRSLTLF-NNSLTEMPSAL P_troglodytes_ENSPTRP00000021076 ------------------------------------------------------SCTSRPHITVVEGEPF------------------------------YLKHCSCSLAHEIETTTKSW M_musculus_ENSMUSP00000091395 -----------------------------------------------------------------------------------------------MASSSSVPASSTPSKKPRDKIADWF 610 620 630 640 650 660 670 680 690 700 710 720 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_mulatta_ENSMMUP00000001339 RRRLSLFL---------------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000379625 RRRLSLFL---------------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000003761 RRRLSLFL---------------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000001633 RRRLSLFL---------------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000025449 RRRLSLFL---------------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000015673 RRRLSLFL---------------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000007386 RRRLSLFL---------------------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000002088 RRRLALFL---------------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000000735 RRRLSLFL---------------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000018341 RRRLSLFL---------------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000035092 RRRLSLFL---------------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000009820 RRRLSLLL---------------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000012280 RRKLGLYL---------------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000015721 RKKLGLYL---------------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000020711 RKKLGLFL---------------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000000429 RRRLGLYL---------------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000039929 RHRLSLYL---------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000044800 RKKVGLYL---------------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000009551 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000004643 RKKLGLYL---------------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000001873 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000020077 RRQLGLHL---------------------------------------------------------------------------------------------------------------- A_aegypti_AAEL007768-PA YELLSALL---------------------------------------------------------------------------------------------------------------- A_gambiae_AGAP005252-PA RELVAELL---------------------------------------------------------------------------------------------------------------- D_melanogaster_FBpp0087679 RTQLSRML---------------------------------------------------------------------------------------------------------------- A_gambiae_AGAP010636-PA FYGLPKLEGLDLSSNKLTRL--SAELFGKNKNLMDFLADNQHSSGL-------------------------------------------------VLEDKLFAGLIMLQKVSVSN-CNIT A_gambiae_AGAP000999-PA ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000045770 FSGLTSLENLVAVETKLASL--ESFPIGQLITLKKLNVAHNFIHS--------------------------------------------------CKLPAYFSNLTNLVHVDLSY-NYIQ R_norvegicus_ENSRNOP00000014020 FSGLTNLENLVAVETKMTSL--EGFHIGQLISLKKLNVAHNLIHS--------------------------------------------------FKLPEYFSNLTNLEHVDLSY-NYIQ M_domestica_ENSMODP00000024473 FYGLPKLQKLVVVETNLMSL--EDFPIGHIITLQELHLGHNSISS--------------------------------------------------LQLPSYFASFSSMKHLDLHL-NQIK A_gambiae_AGAP001002-PA FDKLPNLTQLFLNSNKLTSL--PSGLLKRNTKLTVFRADNQRGSGL-------------------------------------------------VLGDELFAGLTMLEDVSVSN-CKLT T_guttata_ENSTGUP00000009600 IAQDRDLE---------------------------------------------------------------------------------------------------------------- A_aegypti_AAEL000057-PA F-----------------------------------------------------------------------------------------------------HNMQKLKYLSLKS-NELT D_melanogaster_FBpp0084432 FAHLTNVTDINLSANLFRSL--PQGLFDHNKHLNEVRLMNNRVPLA-------------------------------------------------TLPSRLFANQPELQILRL-R-AELQ P_pygmaeus_ENSPPYP00000021907 FSGLSSLQKLVAVETNLASL--ENFPIGHLKTLKELNVAHNLIQS--------------------------------------------------FKLPEYFSNLTNLEHLDLSS-NKIQ A_gambiae_AGAP010634-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010669-PA FYGLPNLTFIDLSSNKLTRL--SAKLFLMNKNLNNFIADNQNGSGL-------------------------------------------------VLEDKLFADLRRLIKVSVSN-CKIT B_taurus_ENSBTAP00000008190 FSGLSSLQKLVAVETNLVSL--NDFPIGHLKNLKELNVAHNFIHS--------------------------------------------------FKLPEYFSNLPNLEHLDLSN-NKIQ O_cuniculus_ENSOCUP00000001909 FSGLSNLQKLVAVETHLTSL--GDFPIGHLKTLKELNVAHNLIHS--------------------------------------------------FSIPDYFSNLSSLEHLDLSN-NKIQ M_domestica_ENSMODP00000018871 TGQDQDLE---------------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000003444 FYGLTSLKKLVLVETNRTSL--SELPIGHLHTLQELNLGHNSITS--------------------------------------------------LKLPKYFTNMTSLRLLSFSS-NKIT D_rerio_ENSDARP00000055005 FHKLKSLQQLNLVGNPYST----------------------------------------------------------------------------VGPAPIFKSLVNLRTLHLGS-PSLR O_anatinus_ENSOANP00000020856 FSGLKMLQKLVAVEMQVVSL--EDLPLGHLTALRELNLGHNFIRS--------------------------------------------------SKLPSYFAHLVSLQYLNLYK-NKIS T_guttata_ENSTGUP00000005321 FGHLFSLQHLHLEGNSYRD----------------------------------------------------------------------------LGQSSPFSSLKNLSSLHLGN-PQFS P_troglodytes_ENSPTRP00000036398 FSGLSSLQKLVAVETNLASL--ENFPIGHLKTLKELNVAHNLIQS--------------------------------------------------FKLPEYFSNLTNLEHLDLSS-NKIQ D_melanogaster_FBpp0075360 FAETKQLQEIYLRNNSINVL--APGIFGELAELLVLDLASNELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFR-PLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSR-NRIS G_gorilla_ENSGGOP00000007772 FSGLSSLQKLVAVETNLASL--ENFPIGHLKTLKELNVAHNLIQS--------------------------------------------------FKLPEYFSNLTNLEYLDLSS-NKIQ H_sapiens_ENSP00000363089 FSGLSSLQKLVAVETNLASL--ENFPIGHLKTLKELNVAHNLIQS--------------------------------------------------FKLPEYFSNLTNLEHLDLSS-NKIQ C_familiaris_ENSCAFP00000031395 FSGLSSLKTLVAKETKLTSL--EDFPIGHLKTLKELNVAHNLIHS--------------------------------------------------FKLPAYFSNMPNLENVDLSN-NKIQ E_caballus_ENSECAP00000008292 FSGLSSLQTLVAVETKLSSL--EKFPIGHLKTLKELNVAHNLIHS--------------------------------------------------FKLPEYFSKMPNLEHLDLSN-NKIQ A_aegypti_AAEL007619-PA FASLKELSRLEITLNPFVSL--PRGLFSENKKLKTLILTNNR-KLV-------------------------------------------------TLPEELLANLKELTVVNLSH-NGVG C_familiaris_ENSCAFP00000020672 TRQDRDLE---------------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000039787 FSGLSSLQKLVAVETNLASL--ENFPIGHLKTLKELNVAHNLIQS--------------------------------------------------FKLPEYFSNLTNLEHLDLSS-NKIQ E_caballus_ENSECAP00000004036 TRQDRDLE---------------------------------------------------------------------------------------------------------------- D_melanogaster_FBpp0080080 LRELQQLRNLSLA------L--IHPFHERDKQLQ----------------------------------------------------------------PHFFGSMTNLEEVRL-A-SATS C_familiaris_ENSCAFP00000015327 RQVLSK------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005325 FGHLFSLQHLHLEGNSYRD----------------------------------------------------------------------------LGQSSPFSSLKNLSSLHLGN-PQFS O_cuniculus_ENSOCUP00000010774 RQALQK------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000029040 FQSLSSLLSLNLL----------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000051260 TRQDRDLE---------------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000015544 FRPLSSLKFLNLLGSTYKT----------------------------------------------------------------------------LGETSLFSHLTNLRILKVGNIH-FT A_carolinensis_ENSACAP00000015503 FGSLSSLLTLNIKGNCYSE----------------------------------------------------------------------------LGENPLFSGLKSLRSLYLGNDDHFS H_sapiens_ENSP00000260010 FKPLSSLTFLNLLGNPYKT----------------------------------------------------------------------------LGETSLFSHLTKLQILRVGNMDTFT G_gorilla_ENSGGOP00000003012 FKPLSSLTFLNLLGNPYKT----------------------------------------------------------------------------LGETSLFSHLTKLQILRVGNMDTFT P_pygmaeus_ENSPPYP00000016910 FKTLSSLTFLNLLGNPYKT----------------------------------------------------------------------------LGETSLFSHLTKLRMLRVGNMDTFT P_troglodytes_ENSPTRP00000028379 FKPLSSLTFLNLLGNPYKT----------------------------------------------------------------------------LGETSLFSHLTKLQILRVGNMDTFT M_musculus_ENSMUSP00000093843 TRQDRDLE---------------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000020834 FKPLSSLKFLNLLGNPYKT----------------------------------------------------------------------------LGETSLFSHLTKLRILRVGNMDTFT A_gambiae_AGAP001004-PA FADLPHLTELAMGVNNFRTL--PDGLFRANRELRKVKLASQRVELE-------------------------------------------------TLPHDLLQMLPALDQVSLER-VGLV M_musculus_ENSMUSP00000029623 FGPLSSLKYLNLMGNPYQT----------------------------------------------------------------------------LGVTSLFPNLTNLQTLRIGNVETFS R_norvegicus_ENSRNOP00000013025 FRPLSSLKYLNLMGNPYRT----------------------------------------------------------------------------LGETSLFSNLTNLQNLRVGNVDTFS A_aegypti_AAEL007613-PA FTLLPDLTVLNLGFNRFTVL--PDNLLSENRKLREFKFINNQAPLQ-------------------------------------------------TLPEAFLGNLPQLKSVILNR-CSFT D_melanogaster_FBpp0079369 CEPYKSHCKFTLGINEVACP--LKCNCSYNRDKSQLEIDCWQKNLT-------------------------------------------------TIPS-LPVPKKGSSALVFQS-NLLA D_rerio_ENSDARP00000015475 LEPLTNLKVLEMSNNLYSQ----------------------------------------------------------------------------ASLGAAFLNFNQLKVLSIGG-PLVS O_anatinus_ENSOANP00000007049 IGQDRDLE---------------------------------------------------------------------------------------------------------------- A_aegypti_AAEL003507-PA FDELPLLSTLNLGFNQLQNI--PKGLLSSNHLMKEFRMINNQGQMD-------------------------------------------------VLPDELFGNLPNLITLILSR-NKFS G_gallus_ENSGALP00000015018 FGPLFSLQHLRIQGNSYSD----------------------------------------------------------------------------LGESSPFSSLRNLSSLHLGN-PQFS C_familiaris_ENSCAFP00000012269 FRPLSSLKFLNLLGNPYKS----------------------------------------------------------------------------LGETPLFSQLTNLRILKVGNIYSFT G_gallus_ENSGALP00000015020 FGPLFSLQHLRIQGNSYSD----------------------------------------------------------------------------LGESSPFSSLRNLSSLHLGN-PQFS B_taurus_ENSBTAP00000010530 FRSLYVLKFLNLLGNLYKT----------------------------------------------------------------------------LGETSLFSHLPNLRTLKVGNSNSFT X_tropicalis_ENSXETP00000048303 FEPLLLLEFLDVSNNLYNY----------------------------------------------------------------------------STLGKVFENLVNLQNLAIGG-PLVS B_taurus_ENSBTAP00000028660 RQALAR------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002918 FRPLSSLKFLNLLENPYRT----------------------------------------------------------------------------LGETSLFSHLPHLRILKVGSLYAFV G_gorilla_ENSGGOP00000013642 RQTLLK------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010425 RQTLLK------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000007258 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000038393 LEPLLLLEVLDLSDNLYNY----------------------------------------------------------------------------STLGKVFKTLANLRSLSIGG-PFVS M_domestica_ENSMODP00000002903 TKRYGRNSTMKLS----------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000026726 FKNIKNLKNLDLSQNFLIKEIGDAEFLKLIPSLVELDLSFNFELQMYSPF---------------------------------------------LNLSKTFSCLSNLETLRIKG-YVFK P_pygmaeus_ENSPPYP00000004627 RQTLLK------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000002280 LTPLLNLKVLNMSNNLYKH----------------------------------------------------------------------------ATLAKSFSRLVSLKVLSMGG-PLVM O_anatinus_ENSOANP00000002290 FRGLSNLLELRLFYCGLSESVLRDGHLRDLRSLIRLDLSANRIQS--------------------------------------------------LPLHASFQELRSLETLDLSK-NQIS M_domestica_ENSMODP00000002923 YKHPQNGS---------------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000029702 TRQDRDLE---------------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000059752 RQTLLK------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000279992 RQTLLK------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000024401 YTSIQRYL---------------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000010139 RQALSK------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000032224 RQALLK------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000072516 TRQDRDLE---------------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000027076 TRQDRDLE---------------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000032922 TGQGKDLE---------------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000009956 LTDLKHLQIFDLSHNRIHTI--QMGTLGPLGALQELDLSFNNVSDFRSVANAVSQLPDFLRLSLSSNFITDLKSEQSVTVLSSLQSLNLRNNSI-SVLDFTFYSMPSLIELNVTR-NNLS P_pygmaeus_ENSPPYP00000016111 TRQDRDLE---------------------------------------------------------------------------------------------------------------- A_aegypti_AAEL000633-PA FSEAKHIKEIYLQNNSINVL--APGIFSELQQLLVLDISNNELTSEWINPATFKGLSRLILLDLANNKISKLEPSIFR-DLFSLQILRLQDNFIETIHEGTFSELTALHTLVISN-NRLS G_gallus_ENSGALP00000001610 RRLLQ------------------------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000004210 XXXXXXXX---------------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000057557 LQYIKNIKRMDLSYNNFKT----------------------------------------------------------------------------MDFCSEFTALSQLKHLGLSS----K A_gambiae_AGAP012385-PA FSEAKHIKEIYLQNNSLNVL--APGIFSDLKQLLVLDLSNNELTSEWINPATFGVVQAHPTRSFKQQNNEARAHDLPRSDQRAGVALRKTSS---KASAKTFLGLGALHTVILSN-NRLC A_carolinensis_ENSACAP00000000788 IGRGQDLE---------------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000054706 LEPLHLLEFLDMSNNFYNK----------------------------------------------------------------------------STLGDVFQTLVNLQTLSIGG-PLVS P_troglodytes_ENSPTRP00000021076 YKSSGSQEHVEL------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000091395 RQALLK------------------------------------------------------------------------------------------------------------------ 730 740 750 760 770 780 790 800 810 820 830 840 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_mulatta_ENSMMUP00000001339 -----------------------------------------------------NVRT--------------------------------------------------------------- H_sapiens_ENSP00000379625 -----------------------------------------------------NVRT--------------------------------------------------------------- G_gorilla_ENSGGOP00000003761 -----------------------------------------------------NVRT--------------------------------------------------------------- E_caballus_ENSECAP00000001633 -----------------------------------------------------NVRT--------------------------------------------------------------- P_troglodytes_ENSPTRP00000025449 -----------------------------------------------------NVRT--------------------------------------------------------------- P_pygmaeus_ENSPPYP00000015673 -----------------------------------------------------NVRT--------------------------------------------------------------- C_familiaris_ENSCAFP00000007386 -----------------------------------------------------NVRT--------------------------------------------------------------- O_cuniculus_ENSOCUP00000002088 -----------------------------------------------------NVRT--------------------------------------------------------------- B_taurus_ENSBTAP00000000735 -----------------------------------------------------NVRA--------------------------------------------------------------- R_norvegicus_ENSRNOP00000018341 -----------------------------------------------------NPRT--------------------------------------------------------------- M_musculus_ENSMUSP00000035092 -----------------------------------------------------NPRT--------------------------------------------------------------- A_carolinensis_ENSACAP00000009820 -----------------------------------------------------NPGA--------------------------------------------------------------- O_latipes_ENSORLP00000012280 -----------------------------------------------------NPKN--------------------------------------------------------------- T_nigroviridis_ENSTNIP00000015721 -----------------------------------------------------NPRN--------------------------------------------------------------- D_rerio_ENSDARP00000020711 -----------------------------------------------------NPTN--------------------------------------------------------------- T_guttata_ENSTGUP00000000429 -----------------------------------------------------NPRA--------------------------------------------------------------- X_tropicalis_ENSXETP00000039929 -----------------------------------------------------NPNA--------------------------------------------------------------- T_rubripes_ENSTRUP00000044800 -----------------------------------------------------NPRN--------------------------------------------------------------- G_gallus_ENSGALP00000009551 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000004643 -----------------------------------------------------NPRN--------------------------------------------------------------- O_anatinus_ENSOANP00000001873 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000020077 -----------------------------------------------------DPER--------------------------------------------------------------- A_aegypti_AAEL007768-PA -----------------------------------------------------NRKK--------------------------------------------------------------- A_gambiae_AGAP005252-PA -----------------------------------------------------NHKR--------------------------------------------------------------- D_melanogaster_FBpp0087679 -----------------------------------------------------NRKK--------------------------------------------------------------- A_gambiae_AGAP010636-PA VLPEKLFAGATE--IQIIN-LSNN-K-LRSL----------------------PENL----FRNLSNLVELNLQKNKLKSMLPDTL-----------------------LADAAQLQTLN A_gambiae_AGAP000999-PA ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000045770 TITVNDLQFLRENPQVNLS-LDMSLNPIDFI----------------------QDQA----FQGI-KLHELTLRGNFNSSNIMKTC-----------------------LQNLAGLHVHR R_norvegicus_ENSRNOP00000014020 TISVKDLQFLRENPQVNLS-LDLSLNPIDSI----------------------QAQA----FQGI-RLHELTLRSNFNSSNVLKMC-----------------------LQNMTGLHVHR M_domestica_ENSMODP00000024473 NISDGDLEPVKLNP--NLT-LDLSENPIQYI----------------------HPGA----FKGI-HLSGLKLRSSFHNSTIMEAC-----------------------IKGMTGLKVGK A_gambiae_AGAP001002-PA TLSAGLFTVASK--LTKLN-LSDN-K-LQSL----------------------PENL----LRHSSNLKELYLQNNELMNKLPDTL-----------------------LQ--------- T_guttata_ENSTGUP00000009600 -----------------------------------------------------EPIN----YRL--PDNHISKDKDTL------------------------------------------ A_aegypti_AAEL000057-PA HVPPTLLKGLTL--LANLD-LSAN-Q-LRLL----------------------PPDL----LRNHTQLFRSDLSKNDI-ETLPEML-----------------------FETNAALQYVN D_melanogaster_FBpp0084432 SLPGDLFEHSTQ--ITNIS-LGDN-L-LKTL----------------------PATL----LEHQVNLLSLDLSNNRL-THLPDSL-----------------------FAHTTNLTDLR P_pygmaeus_ENSPPYP00000021907 SIYCKDLQVLHQMPLLNLS-LDLSLNAMNFI----------------------QPGA----FKEI-RLHKLTLRNSFDSLNVMKTC-----------------------IQGLAGLEVHH A_gambiae_AGAP010634-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010669-PA ALPECLFAGATG--ITFID-FSSN-K-LQSL----------------------PEHL----FRGLSNLRWLYLQDNELMRMLPDTL-----------------------LQDAINLRVLH B_taurus_ENSBTAP00000008190 NIYYEDVKVLHQMPLLNLS-LDLSLNPLDFI----------------------EPGT----FKEI-KLNGLTLRSNFNSSHVMKTC-----------------------IQGLAGLKTNR O_cuniculus_ENSOCUP00000001909 SIYHKDLRVLHQMPLGTLS-LDLSLNPIDFI----------------------QPGA----FEAI-RLHELILKSNFKSTNIMKIC-----------------------IQGLSGLEVHR M_domestica_ENSMODP00000018871 -----------------------------------------------------EPIN----FRL--PDNRISKEKDLI------------------------------------------ T_guttata_ENSTGUP00000003444 SISRGDLDALREGNRLNLT-LVLSLNNIKSI----------------------EPGA----FAGI-HLAELALRSAFEKPT-MQTA-----------------------LQGLAGLQVSR D_rerio_ENSDARP00000055005 ELHKNGLDVLTH--LDEMT-FF-GSN-LRSY----------------------ENGS----LKAARPIGSVSLSLQNLFESDPELVSKV--------------------LQDVSH-PETL O_anatinus_ENSOANP00000020856 MILLEDLNVLKQRQQPLLT-LVLSLNNILNI----------------------ELGS----FEGL-HLQALEMRGCFNDVNVTKTC-----------------------INALAGLQVHQ T_guttata_ENSTGUP00000005321 VIRHGNFEGIEL--LHKLW-ID-GSN-LSQY----------------------EQGS----LKSIKQINHMILNLRN-----GYIFSEI--------------------VRDLLH-SVTW P_troglodytes_ENSPTRP00000036398 SIYCTDLRVLHQMPLLNLS-LDLSLNPMNFI----------------------QPGA----FKEI-RLHKLTLRNNFDSLNVMKTC-----------------------IQGLAGLEVHR D_melanogaster_FBpp0075360 VIEQRTLQGLKN--LLVLS-LDFN-R-ISRM----------------------DQRS----LVNCSQLQDLHLNDNKL-QAVPEALAHVQLLKTLDVGENMISQIENTSITQLESLYGLR G_gorilla_ENSGGOP00000007772 SIYCTDLRVLHQMPLLNLS-LDLSLNPMTFI----------------------QPGA----FKEI-RLHKLTLRNNFDSLNVMKTC-----------------------IQGLAGLEVRR H_sapiens_ENSP00000363089 SIYCTDLRVLHQMPLLNLS-LDLSLNPMNFI----------------------QPGA----FKEI-RLHKLTLRNNFDSLNVMKTC-----------------------IQGLAGLEVHR C_familiaris_ENSCAFP00000031395 NIYREDLQVLHHMPLLNLS-LDLSLNPLYFI----------------------QPGS----FKEI-KLHKLTLRSNFNSTDVMKTF-----------------------IQGLAGLKINQ E_caballus_ENSECAP00000008292 NISHEDLRVLHQMPLLNLS-LDLSLNPLEFI----------------------QPDA----FKEI-KLHKLTLRSNFDSIDVMKSC-----------------------IQGLAGLKVNR A_aegypti_AAEL007619-PA NLPESLLSGSLG--IIELN-LGYN-R-LNSL----------------------PEEL----LSDQLQLQVLNLDHNQL-ESIPDYF-----------------------LERNVELQTLY C_familiaris_ENSCAFP00000020672 -----------------------------------------------------EPIN----FRL--PDNRISKEKDVL------------------------------------------ M_mulatta_ENSMMUP00000039787 NIYCKDLQVLHQMPLSNLS-LDLSLNPINFI----------------------QPGA----FKEI-RLHKLTLRSNFDDLNVMKTC-----------------------IQGLAGLEVHR E_caballus_ENSECAP00000004036 -----------------------------------------------------EPIN----FRL--PENRISKEKDVL------------------------------------------ D_melanogaster_FBpp0080080 SVNRSMFKGTNK--LQLIK-MNGNDD-LMEL----------------------PGEI----FLDQVNLKTLDLSCNAI-VTLHEDV-----------------------FKGLGNLTLLD C_familiaris_ENSCAFP00000015327 -----------------------------------------------------TSKK--------------------------------------------------------------- T_guttata_ENSTGUP00000005325 VIRHGNFEGIEL--LHKLW-ID-GSN-LSQY----------------------EQGS----LKSIKQINHMILNLRN-----GYIFSEI--------------------VRDLLH-SVTW O_cuniculus_ENSOCUP00000010774 -----------------------------------------------------KPAK--------------------------------------------------------------- O_anatinus_ENSOANP00000029040 ------------------------------Y----------------------QPHS----LQSTQNINHLLLNVTK-----SDIVLKI--------------------LSDLTS-S--- R_norvegicus_ENSRNOP00000051260 -----------------------------------------------------EPIN----FRL--PENRISKEKDVL------------------------------------------ E_caballus_ENSECAP00000015544 EIQGKDFAGLTF--LEELE-ID-ATN-LQRY----------------------EPKS----FKSIQNISHLILRMKQ-----PVLLPEI--------------------ILDTLS-SLEY A_carolinensis_ENSACAP00000015503 ALRTHDLEGISV--LEELE-LV-GPK-LKQY----------------------EPRS----LPSTVLINNLILNDPS-----RITLLML--------------------MRDVRD-NVIS H_sapiens_ENSP00000260010 KIQRKDFAGLTF--LEELE-ID-ASD-LQSY----------------------EPKS----LKSIQNVSHLILHMKQ-----HILLLEI--------------------FVDVTS-SVEC G_gorilla_ENSGGOP00000003012 KIQRKDFAGLTF--LEELE-ID-ASD-LQSY----------------------EPKS----LKSIQNVSHLILHMKQ-----HXLLLEI--------------------FVDVTS-SVEC P_pygmaeus_ENSPPYP00000016910 KIQRKDFAGLTF--LEELE-ID-ASD-LQSY----------------------EPKS----LKSIQNVSHLILHMKQ-----HTLLLEI--------------------FVDVTS-SVEC P_troglodytes_ENSPTRP00000028379 KIQRKDFAGLTF--LEELE-ID-ASD-LQSY----------------------ESKS----LKSIQNVSHLILHMKQ-----HILLLEI--------------------FVDVTS-SVEC M_musculus_ENSMUSP00000093843 -----------------------------------------------------EPIN----FRL--PENRISKEKDVL------------------------------------------ M_mulatta_ENSMMUP00000020834 KIQRKDFAGLTF--LEELE-ID-ASD-LQSY----------------------EPKS----LKSIQNVSHLILHMKQ-----HILLLEI--------------------FVDLTS-SVEC A_gambiae_AGAP001004-PA SLPGTLLFGSAN--LTQLN-LANN-R-LHQL----------------------PEDL----LRDQKALQVLQLQHNQL-TGLPAGL-----------------------LRNTVELHTLR M_musculus_ENSMUSP00000029623 EIRRIDFAGLTS--LNELE-IK-ALS-LRNY----------------------QSQS----LKSIRDIHHLTLHLSE-----SAFLLEI--------------------FADILS-SVRY R_norvegicus_ENSRNOP00000013025 EIRRIDFAGLTS--LNELE-IQ-VLS-LGNY----------------------ESRS----LQSIRDIYHLTLHLSE-----SAFLLGI--------------------FADILS-SVRY A_aegypti_AAEL007613-PA HLPASLFRGSSE--ITHMD-LSYN-Q-LGSV----------------------PELL----LRDQLRLQDLNLAYNEL-ESLPEHL-----------------------LENTRELLTLR D_melanogaster_FBpp0079369 ELPDNSLEGYHN--LKSLD-VSYN-Q-LTSL----------------------SVSQ----LPES--LHYLDIRHNKI-TTLSPQV-----------------------VEYLYSVNVFN D_rerio_ENSDARP00000015475 SLGSRDIYVLKNISLDKFA-VKTGTG-FRDY----------------------EPGY----FKSL-STKHLWFDIAF--DKNPDLLPKM--------------------LKDLANKTFDV O_anatinus_ENSOANP00000007049 -----------------------------------------------------EPIN----FRL--PDNRISKEKDIL------------------------------------------ A_aegypti_AAEL003507-PA EIPSSLFIGSSA--IQHID-FSYN-N-LRHL----------------------PEQL----LRDQHWLQHLNVANNRL-EVIPDEL-----------------------LENTSELTFLD G_gallus_ENSGALP00000015018 IIRQGNFEGIVF--LNTLR-ID-GDN-LSQY----------------------EPGS----LKSIRKINHMIISIRR-----IDVFSAV--------------------IRDLLH-SAIW C_familiaris_ENSCAFP00000012269 EIQDKDFAGLTF--LEELE-ID-ASN-LQRY----------------------EPKS----LKSIQNISYLALRMKQ-----PVLLVEI--------------------FVDLSS-SLKH G_gallus_ENSGALP00000015020 IIRQGNFEGIVF--LNTLR-ID-GDN-LSQY----------------------EPGS----LKSIRKINHMIISIRR-----IDVFSAV--------------------IRDLLH-SAIW B_taurus_ENSBTAP00000010530 EIHEKDFTGLTF--LEELE-IS-AQN-LQIY----------------------VPKS----LKSIQNISHLILHLKQ-----PILLVDI--------------------LVDIVS-SLDC X_tropicalis_ENSXETP00000048303 KVLKDDFAPIKNRSLKKFS-LKTMSK-LGFY----------------------EPGA----LEVL-NTRVLWLDISL--DTNAQALPLI--------------------LKDLAGKTIDS B_taurus_ENSBTAP00000028660 -----------------------------------------------------KPTK--------------------------------------------------------------- O_cuniculus_ENSOCUP00000002918 NIRRMDFAGVRS--LEELE-ID-GSN-LQSY----------------------EPRG----LGSIPNVSRLVLHLRQ-----PTLLLKL--------------------FPDLLS-SVEC G_gorilla_ENSGGOP00000013642 -----------------------------------------------------KPKK--------------------------------------------------------------- M_mulatta_ENSMMUP00000010425 -----------------------------------------------------KPKK--------------------------------------------------------------- A_carolinensis_ENSACAP00000007258 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000038393 KVLRGDFVPIKNISLQKFE-LKTRSS-LRFY----------------------QTGA----FSVL-NTDVLVLVMTL--DTNPKVLPMI--------------------LKDLAGKSLDI M_domestica_ENSMODP00000002903 ------------------------------------------------------------------SNENIIINGSVI------------------------------------------ G_gallus_ENSGALP00000026726 ELREENLDPLLN--LRNLTVLDLGTNFIKIA----------------------DLRV----FKKFRSLKIIDLSMNKISPSSGEGN-----------------------FYGFCSDHRIT P_pygmaeus_ENSPPYP00000004627 -----------------------------------------------------KPKK--------------------------------------------------------------- G_aculeatus_ENSGACP00000002280 GLKKADFQPLKNIRLQGFA-IKCSTN-LKYY----------------------EPGS----LEVI-QTNQMGFDMAI--DQQPSALPHM--------------------LRDLANKTFSA O_anatinus_ENSOANP00000002290 SVCERDLQSLRGKHLSLLNLADNQLFSCRPV----------------------DWGACGNPFRNI-FLDTLDVSGNGWSANITQDF-----------------------CAAINGTRVSS M_domestica_ENSMODP00000002923 -----------------------------------------------------QPYA------ILNEHSHITWENHLL------------------------------------------ M_mulatta_ENSMMUP00000029702 -----------------------------------------------------EPIN----FRL--PENRISKEKDVL------------------------------------------ P_troglodytes_ENSPTRP00000059752 -----------------------------------------------------KPKK--------------------------------------------------------------- H_sapiens_ENSP00000279992 -----------------------------------------------------KPKK--------------------------------------------------------------- C_intestinalis_ENSCINP00000024401 -----------------------------------------------------EPLC--------------------------------------------------------------- E_caballus_ENSECAP00000010139 -----------------------------------------------------KPK---------------------------------------------------------------- R_norvegicus_ENSRNOP00000032224 -----------------------------------------------------KPKK--------------------------------------------------------------- H_sapiens_ENSP00000072516 -----------------------------------------------------EPIN----FRL--PENRISKEKDVL------------------------------------------ P_troglodytes_ENSPTRP00000027076 -----------------------------------------------------EPIN----FRL--PENRISKEKDVL------------------------------------------ X_tropicalis_ENSXETP00000032922 -----------------------------------------------------EPVN----IRL--PNNRIIKDKDTL------------------------------------------ X_tropicalis_ENSXETP00000009956 AVNKSSFSNLPM--LAKVT-FDENSLNISQLLGLVLPNLTEFHWSSMRPALQHELVSACQVFQTFPKLQLLDIKHSKIAVTNLSIIGRCTNLTSLILSTSPLPRLQEKDLQDFKYLEVLY P_pygmaeus_ENSPPYP00000016111 -----------------------------------------------------EPIN----FRL--PENRISKEKDVL------------------------------------------ A_aegypti_AAEL000633-PA NIEYFSFQGLSR--LTLLS-LDYN-R-ISRI----------------------DRVA----FRNLSTLHDLHLNGNKL-LQVPDALYDVPLLRTLDLGENHISNIDNASFKEMFHMYGLR G_gallus_ENSGALP00000001610 -----------------------------------------------------KPKQ--------------------------------------------------------------- O_cuniculus_ENSOCUP00000004210 -----------------------------------------------------XXXX----XXX--XXXXXXXXXXXX------------------------------------------ X_tropicalis_ENSXETP00000057557 KIQKDSFINIASMDLDFVF-LG-IEN-EIEY----------------------ENGS----LQFL-NTNKLHINLQP---NLSLASSYL--------------------LSDALD-TSMT A_gambiae_AGAP012385-PA TVDHFTFSGLNS--LALLS-LDYN-R-ISRI----------------------DRQA----LRNHSALQELHLNGNKL-LQVPDALYDVPLLRTLDLGENHISNIDNASFRHMAHLYGLR A_carolinensis_ENSACAP00000000788 -----------------------------------------------------EPIN----FRL--PDNHISKEKDTL------------------------------------------ X_tropicalis_ENSXETP00000054706 KVQKDDFVPIRNIGLQKFA-LKTMSS-LTLY----------------------EEGA----FSVL-NTHVLWFDIAL--DTNPQALLLI--------------------LKDLK------ P_troglodytes_ENSPTRP00000021076 -----------------------------------------------------NPRS----------SSRIALHDCVL------------------------------------------ M_musculus_ENSMUSP00000091395 -----------------------------------------------------KPKK--------------------------------------------------------------- 850 860 870 880 890 900 910 920 930 940 950 960 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_mulatta_ENSMMUP00000001339 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000379625 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000003761 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000001633 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025449 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015673 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000007386 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002088 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000000735 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000018341 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000035092 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009820 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000012280 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000015721 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000020711 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000000429 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000039929 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000044800 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000009551 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000004643 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000001873 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000020077 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007768-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP005252-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0087679 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010636-PA LCHN------------------------KLTTVNKHLLQSL------------------GNLSKLQLSHNLLYLIDVDAFKSQSK----------------------------------- A_gambiae_AGAP000999-PA ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000045770 LILG-----EFKDERNLEIFEPSIMEGLCDVTIDEFRLTYTNDF-SDDIVK-FHCLANVSAMSLAGVSIKYLEDVPKHF----------------------------------------- R_norvegicus_ENSRNOP00000014020 LILG-----EFKNERNLESFDRSVMEGLCNVSIDEFRLTYINHF-SDDIYN-LNCLANISAMSFTGVHIKHIADVPRHF----------------------------------------- M_domestica_ENSMODP00000024473 LVLG-----NYKNDIQMTSFESSILDGLCEVDIGEFRMVQPSQF-PSDGNGVFKCLVNVSVLFLVNTDIDQLTNLPIFP----------------------------------------- A_gambiae_AGAP001002-PA -------------------------------------ISNL------------------PKLETLYLDKNKLKHVSQ------------------------------------------- T_guttata_ENSTGUP00000009600 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL000057-PA ISHN------------------------SLITLPSKLFHTL------------------QKLISLDLSNNQLSSLDPDIF-EQSP----------------------------------- D_melanogaster_FBpp0084432 LEDN------------------------LLTGISGDIFSNL------------------GNLVTLVMSRNRLRTIDSRAF-VSTN----------------------------------- P_pygmaeus_ENSPPYP00000021907 LVLG-----EFRNEKNLEKFDTSALEGLCNLTIEEFRLAYLDYY-LDDIIDLFNCLANVSSFSLVSVTIKSVKDFSYNF----------------------------------------- A_gambiae_AGAP010634-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010669-PA LCYN------------------------KLTMLNKHLLKSL------------------RHLEKLHLEHNQLHMIDVDAFTSQTE----------------------------------- B_taurus_ENSBTAP00000008190 LVLG-----EFKNERKLQRFDRSFLEGLCNLTIEQFRIAYLDKF-SGDDTDLFNCLANVSVISLLSISLGSLQALLKDF----------------------------------------- O_cuniculus_ENSOCUP00000001909 LVLG-----EFKNERNMKNFDKSALEGLCNLAIEEFRLAYIDDL-EGNITDLFDCLENVSVMALVHMYIDNQEIFPKDF----------------------------------------- M_domestica_ENSMODP00000018871 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000003444 LIVG-----EFRNIERLQDFEGRLLDGLCQVQMEEFVLICLRGF-KDDTDTLFNCIGNVSTIRLVDLGLKEISQVPVWS----------------------------------------- D_rerio_ENSDARP00000055005 LIIK-----DVT--MKTNTST-EPFKMVKEGGTKSLTFQNS-STTDQALTSFLEFMDG-SPLSFIGLEDIQFVGIGEW-QKAK---YTHHD----------------------------- O_anatinus_ENSOANP00000020856 LVLG-----DFRENHNDMPEDFGVFDGLCKVDIEEFRIVYYKGL-IYNTNIFSNCLLNVSVLRVVSTSLNEVANLPAAT----------------------------------------- T_guttata_ENSTGUP00000005321 LEVT-----EIK--LPVERKS-LVQNSTRPFRIQKLTFKEA-FFTDETISRTIVSLKEITSLKELEAINCVLEGKGIW--NTKEIARSGQS----------------------------- P_troglodytes_ENSPTRP00000036398 LVLG-----EFRNEGNLEKFDKSALEGLCNLTMEEFRLAYLDYY-LDDIIDLFNCLTNVSSFSLVSVTIKSVKDFSYNF----------------------------------------- D_melanogaster_FBpp0075360 MTEN------------------------SLTHIRRGVFDRM------------------SSLQILNLSQNKLKSIEAGSL-QRNS----------------------------------- G_gorilla_ENSGGOP00000007772 LVLG-----EFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYY-LDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNF----------------------------------------- H_sapiens_ENSP00000363089 LVLG-----EFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYY-LDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNF----------------------------------------- C_familiaris_ENSCAFP00000031395 LVLG-----EFKNERKLESFDNSLLEGLCNLTIEKFRIAYFDSF-SKDTTNLFNQLVNISAISLAHLYLDTPKYLPKNL----------------------------------------- E_caballus_ENSECAP00000008292 LVLG-----EFKNERKLERFDTSALRGLHNLTIEEFRLAYIDNYSSKDSIDLLNCLANISKISLVSLDLGNLQDFPKGF----------------------------------------- A_aegypti_AAEL007619-PA LSHN------------------------RLRSLSEKAFTKL------------------KNLKELHLENNQLQTIPQFLF-SGTP----------------------------------- C_familiaris_ENSCAFP00000020672 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000039787 LVLG-----EFRNERNLEEFDKSSLEGLCNLTIEEFRLTYLDYY-LDNIIDLFNCLANVSSFSLVSVSIKRVEDFSYNF----------------------------------------- E_caballus_ENSECAP00000004036 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0080080 LSKN------------------------RLTNLSSTIFAPL------------------TSLNVLRLNKNSLTAMSPSVF-QDVV----------------------------------- C_familiaris_ENSCAFP00000015327 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005325 LEVR-----RIA--FSIAAEM-QVLRVMSSSFAKKISFRQT-LLTDATVPEIVSILEDMPQLVELELVDCRLLGTGQW--KMEIQAKKSQT----------------------------- O_cuniculus_ENSOCUP00000010774 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000029040 -KPR-----NI-----------SMSIPVASPQLKRIELRHV-EMTDSWRLEDSRHL---------------------------------------------------------------- R_norvegicus_ENSRNOP00000051260 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000015544 LELR-----DTY--LNTFHFA-EVSDPETNTLIKKFTFRNV-KITDESFDEIVKLLNYISGVSEAEFDECTLDGLGEF-RTPDIDKIKVIG----------------------------- A_carolinensis_ENSACAP00000015503 LELR-----NIQ---NVGQLH-HLSLD--DIPAQKLVFRNI-TVSDHDVVLFIRFLATVSRLHHLEVLDSHLQGHGIF-SGIQ----DISN----------------------------- H_sapiens_ENSP00000260010 LELR-----DTD--LDTFHFS-ELSTGETNSLIKKFTFRNV-KITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNF-RASDNDRVIDPG----------------------------- G_gorilla_ENSGGOP00000003012 LELX-----DTD--LDTFHFS-ELSTGETNSLIKKFTFRNV-KITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNF-RASDNDRVIDPG----------------------------- P_pygmaeus_ENSPPYP00000016910 LELQ-----DTD--LDTFHFS-ELSTGETNSLIKKFTFRNV-KITDEGLFQVMKLLNQISGLLELEFDDCTLNGVGNF-RASDNDRVIDPG----------------------------- P_troglodytes_ENSPTRP00000028379 LELR-----DTD--LDTFRFS-ELSTGETNSLIKKFTFRNV-KITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNF-RASDNDRVIDPG----------------------------- M_musculus_ENSMUSP00000093843 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000020834 LELR-----DTD--LNTFHFS-ELSTGETNSLIKKFTFRNV-KITDESLFQVMKLLSQISGLLELEFDDCTLNGVGDF-RGSDNDRVIDPG----------------------------- A_gambiae_AGAP001004-PA LSHN------------------------QIGELSAVALQAL------------------TKLQELYLDHNQLYTIELHAF-KQTT----------------------------------- M_musculus_ENSMUSP00000029623 LELR-----DTN--LARFQFS-PLPVDEVSSPMKKLAFRGS-VLTDESFNELLKLLRYILELSEVEFDDCTLNGLGDF-NPSESDVVSELG----------------------------- R_norvegicus_ENSRNOP00000013025 LELR-----DTN--LARFQFS-ELSVDEINSPMKKLAFRNA-DLTDKSFNELLKLLRYILELMEVEFDHCTLNGVGNF-NPSESDVVRELG----------------------------- A_aegypti_AAEL007613-PA LSYN------------------------RLYNLSANIFASL------------------DKLTELHLNDNFLHAIDRLTF-SNTK----------------------------------- D_melanogaster_FBpp0079369 QYGN-----KWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSFVENFFVQNIDQLYLEANEDEIIDAFGPSDKYF----------------------------------- D_rerio_ENSDARP00000015475 LRFR-----NLFEFQYYTGKR-DIFYGLQYVNAQTLTFYRG-KFNEEVMRMALKNVEI-SPIKALELLLIDFARSQ---NRTQGSS-VKNL----------------------------- O_anatinus_ENSOANP00000007049 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003507-PA FSFN------------------------RLQNISAKAFASL------------------DKLIELHLENNGILEIDLFAF-SAAG----------------------------------- G_gallus_ENSGALP00000015018 LEVR-----EIK--LDIENEK-LVQNSTLPLTIQKLTFTGA-SFTDKYISQIAVLLKEIRSLRELEAIDCVLEGKGAW-DMTEIARSKQSS----------------------------- C_familiaris_ENSCAFP00000012269 LELR-----DTH--LDTFHFS-EASINETHTLVKKWTFRNV-KVTDRSFTEVVRLLNYVSGVLEVEFEDCTLYGLGDF-DIPDVDKIKNIG----------------------------- G_gallus_ENSGALP00000015020 LDVR-----KLA--FSVPEKI-QLLRIMSSSFAKKISLKQC-LFTDATVPEIVSILEGMPKLMEVEMKDCTLLGTGKW--YKQIHANQSQS----------------------------- B_taurus_ENSBTAP00000010530 FELR-----DTN--LHTFHFS-EASISEMSTSVKKLIFRNV-QFTDESFVEVVKLFNYVSGILEVEFDDCTHDGIGDF-RALSLDRIRHLG----------------------------- X_tropicalis_ENSXETP00000048303 LRFR-----RLFESSYYTDTM-DLFCGLVDINIRELIFFRG-MFTENLLHQALHSIQK-STIQDLLLLSVKFDRSL---NTNNTHILFDRL----------------------------- B_taurus_ENSBTAP00000028660 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002918 LELR-----ETD--LEDFRFS-GLSVTEPNPRITRFIFRSK-KITDESCNEILKLLAYPPHL-DLEXXXXXXXXXXXX-XXXXXXXXXXXX----------------------------- G_gorilla_ENSGGOP00000013642 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010425 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000007258 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000038393 LSFG-----NLF---------------LPDINVRELIFNRG-KVNQKLLQLILETIQT-SSIQDLSLLSVDFDYSD---VRTTVDVKMDNL----------------------------- M_domestica_ENSMODP00000002903 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000026726 VE----------------QYSRHVLQEMHYFRYDEYGRSCKSKDKEADSYQPLVNGDCMSYGETLDLSRNNIFFVNSIDFQDLS------------------------------------ P_pygmaeus_ENSPPYP00000004627 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000002280 IQFR-----NLFEFMYYMGEE-DIFQGLKYITAHQLIFHRG-KFNENLLRMALINLQV-TPIKSLRLQYIDFARSPTFVDSGASSS-ITDL----------------------------- O_anatinus_ENSOANP00000002290 LVLRHHVMGSGFGFENLKEPNSDTFSGLERSSAVQLDLSHGFIFSLGT-----RLFWALKRLKVLSLTHNKINKFEKGAFY--------------------------------------- M_domestica_ENSMODP00000002923 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029702 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000059752 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000279992 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000024401 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010139 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000032224 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000072516 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000027076 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000032922 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000009956 LDKCKLRRIANSSWRGLNNLHTLILERNQLSDLEDKLFSPL------------------TSLQYLDLSKNYLTHLNEKAFSGLR------------------------------------ P_pygmaeus_ENSPPYP00000016111 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL000633-PA LTEN------------------------NVETIRKGTFDAM------------------KSLQILNLSKNRLKKVDAACF-DNNT----------------------------------- G_gallus_ENSGALP00000001610 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000004210 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000057557 LEVS-----GAQCDVHCDYFTKSFFTINKNSKVVNLIISNS-TMPGNEMLKIIPPIWD-SSVEHLHIKMFRLIKEFKYVKMDFTHH---------------------------------- A_gambiae_AGAP012385-PA LTEN------------------------NIEIIRRGTFEAM------------------KSLHILNLSQNRLKTVEQASF-DNNT----------------------------------- A_carolinensis_ENSACAP00000000788 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000054706 ---------------------------LPSISTRELVFYRG-KFNENLLWIMLENIQR-SSILDLSLLSVDFSRSH---SANKTNTTVEFLDLSHSQLEQLDMDYFNKATNLKQLILSHN P_troglodytes_ENSPTRP00000021076 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000091395 ------------------------------------------------------------------------------------------------------------------------ 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_mulatta_ENSMMUP00000001339 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000379625 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000003761 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000001633 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025449 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015673 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000007386 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002088 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000000735 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000018341 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000035092 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009820 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000012280 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000015721 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000020711 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000000429 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000039929 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000044800 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000009551 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000004643 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000001873 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000020077 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007768-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP005252-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0087679 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010636-PA --------------------------------------------------------------------------------------------------------------SLTSLKLDH- A_gambiae_AGAP000999-PA ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000045770 --------------------------------------------------------------------------------------------------------------KWQSLSIIR- R_norvegicus_ENSRNOP00000014020 --------------------------------------------------------------------------------------------------------------KWQSLSIIR- M_domestica_ENSMODP00000024473 --------------------------------------------------------------------------------------------------------------KLFSLSLTD- A_gambiae_AGAP001002-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000009600 --------------------------------------------------------------------------------------------------------------WFWPALLND- A_aegypti_AAEL000057-PA --------------------------------------------------------------------------------------------------------------YVIFLYLQN- D_melanogaster_FBpp0084432 --------------------------------------------------------------------------------------------------------------GLRHLHLDH- P_pygmaeus_ENSPPYP00000021907 --------------------------------------------------------------------------------------------------------------GWQHLELVN- A_gambiae_AGAP010634-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010669-PA --------------------------------------------------------------------------------------------------------------SLITLNLSR- B_taurus_ENSBTAP00000008190 --------------------------------------------------------------------------------------------------------------RWQHLEIIN- O_cuniculus_ENSOCUP00000001909 --------------------------------------------------------------------------------------------------------------SWKSLEFIN- M_domestica_ENSMODP00000018871 --------------------------------------------------------------------------------------------------------------WFRPTLLND- T_guttata_ENSTGUP00000003444 --------------------------------------------------------------------------------------------------------------KVRQLECKK- D_rerio_ENSDARP00000055005 --------------------------------------------------------------------------------------------------------------SLRTAYLRN- O_anatinus_ENSOANP00000020856 --------------------------------------------------------------------------------------------------------------RWQTLHFNR- T_guttata_ENSTGUP00000005321 --------------------------------------------------------------------------------------------------------------FVETVTVTK- P_troglodytes_ENSPTRP00000036398 --------------------------------------------------------------------------------------------------------------GWQHLELVN- D_melanogaster_FBpp0075360 --------------------------------------------------------------------------------------------------------------QLQAIRLDG- G_gorilla_ENSGGOP00000007772 --------------------------------------------------------------------------------------------------------------GWQHLELVN- H_sapiens_ENSP00000363089 --------------------------------------------------------------------------------------------------------------GWQHLELVN- C_familiaris_ENSCAFP00000031395 --------------------------------------------------------------------------------------------------------------RWQRLEIVN- E_caballus_ENSECAP00000008292 --------------------------------------------------------------------------------------------------------------GWQDFELVN- A_aegypti_AAEL007619-PA --------------------------------------------------------------------------------------------------------------KLEEIYMQN- C_familiaris_ENSCAFP00000020672 --------------------------------------------------------------------------------------------------------------WFRPTLLND- M_mulatta_ENSMMUP00000039787 --------------------------------------------------------------------------------------------------------------RWQHLELVN- E_caballus_ENSECAP00000004036 --------------------------------------------------------------------------------------------------------------WFRPTLLND- D_melanogaster_FBpp0080080 --------------------------------------------------------------------------------------------------------------SLNYIEMVN- C_familiaris_ENSCAFP00000015327 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005325 ---------------------------------------------------------------------------------------------------------------LRILTIKK- O_cuniculus_ENSOCUP00000010774 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000029040 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000051260 --------------------------------------------------------------------------------------------------------------WFRPTLLND- E_caballus_ENSECAP00000015544 --------------------------------------------------------------------------------------------------------------KLETLTIRR- A_carolinensis_ENSACAP00000015503 --------------------------------------------------------------------------------------------------------------TLDVIVIRN- H_sapiens_ENSP00000260010 --------------------------------------------------------------------------------------------------------------KVETLTIRR- G_gorilla_ENSGGOP00000003012 --------------------------------------------------------------------------------------------------------------KVETLTIRR- P_pygmaeus_ENSPPYP00000016910 --------------------------------------------------------------------------------------------------------------KVETLTIRR- P_troglodytes_ENSPTRP00000028379 --------------------------------------------------------------------------------------------------------------KVETLTIRR- M_musculus_ENSMUSP00000093843 --------------------------------------------------------------------------------------------------------------WFRPTLLND- M_mulatta_ENSMMUP00000020834 --------------------------------------------------------------------------------------------------------------KVETLTIRR- A_gambiae_AGAP001004-PA --------------------------------------------------------------------------------------------------------------ALHTLHLQV- M_musculus_ENSMUSP00000029623 --------------------------------------------------------------------------------------------------------------KVETVTIRR- R_norvegicus_ENSRNOP00000013025 --------------------------------------------------------------------------------------------------------------KVETVTIRS- A_aegypti_AAEL007613-PA --------------------------------------------------------------------------------------------------------------ALGKLYMQN- D_melanogaster_FBpp0079369 --------------------------------------------------------------------------------------------------------------NLKLMEALN- D_rerio_ENSDARP00000015475 --------------------------------------------------------------------------------------------------------------SLDRLVLSD- O_anatinus_ENSOANP00000007049 --------------------------------------------------------------------------------------------------------------WFRPTLLND- A_aegypti_AAEL003507-PA --------------------------------------------------------------------------------------------------------------NLQSLFLQN- G_gallus_ENSGALP00000015018 ---------------------------------------------------------------------------------------------------------------IETLSITN- C_familiaris_ENSCAFP00000012269 --------------------------------------------------------------------------------------------------------------QIETLTVRR- G_gallus_ENSGALP00000015020 ---------------------------------------------------------------------------------------------------------------LRILTIEN- B_taurus_ENSBTAP00000010530 --------------------------------------------------------------------------------------------------------------NVETLTIRK- X_tropicalis_ENSXETP00000048303 --------------------------------------------------------------------------------------------------------------YLNSLVIRD- B_taurus_ENSBTAP00000028660 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002918 --------------------------------------------------------------------------------------------------------------XXXXXXXXX- G_gorilla_ENSGGOP00000013642 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010425 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000007258 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000038393 --------------------------------------------------------------------------------------------------------------FLRSLVIKD- M_domestica_ENSMODP00000002903 --------------------------------------------------------------------------------------------------------------EFWPIKMND- G_gallus_ENSGALP00000026726 --------------------------------------------------------------------------------------------------------------FLKCLNLSG- P_pygmaeus_ENSPPYP00000004627 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000002280 --------------------------------------------------------------------------------------------------------------ALDKLDIWY- O_anatinus_ENSOANP00000002290 --------------------------------------------------------------------------------------------------------------GLDTLQILN- M_domestica_ENSMODP00000002923 --------------------------------------------------------------------------------------------------------------QFSPVGIND- M_mulatta_ENSMMUP00000029702 --------------------------------------------------------------------------------------------------------------WFRPTLLND- P_troglodytes_ENSPTRP00000059752 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000279992 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000024401 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010139 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000032224 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000072516 --------------------------------------------------------------------------------------------------------------WFRPTLLND- P_troglodytes_ENSPTRP00000027076 --------------------------------------------------------------------------------------------------------------WFRPTLLND- X_tropicalis_ENSXETP00000032922 --------------------------------------------------------------------------------------------------------------WFRPAIIND- X_tropicalis_ENSXETP00000009956 --------------------------------------------------------------------------------------------------------------RLNYLSLKG- P_pygmaeus_ENSPPYP00000016111 --------------------------------------------------------------------------------------------------------------WFRPTLLND- A_aegypti_AAEL000633-PA --------------------------------------------------------------------------------------------------------------NLQAIRLDG- G_gallus_ENSGALP00000001610 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000004210 --------------------------------------------------------------------------------------------------------------XXXXXXXXX- X_tropicalis_ENSXETP00000057557 --------------------------------------------------------------------------------------------------------------SIKSFTLEY- A_gambiae_AGAP012385-PA --------------------------------------------------------------------------------------------------------------KLQAIRLDG- A_carolinensis_ENSACAP00000000788 --------------------------------------------------------------------------------------------------------------WFRPALLND- X_tropicalis_ENSXETP00000054706 KIKFISSEWKSPNLQVLALEDNSFGVINVGSFKDLPKLRNLTAGDNPYGCTCDLYRFFSQIRELRALNLSYNNISAIETGSFASNVLLTNLTLFNNSLTEMPSALFEPLRFLQFLDISNN P_troglodytes_ENSPTRP00000021076 --------------------------------------------------------------------------------------------------------------EFWPVELND- M_musculus_ENSMUSP00000091395 ------------------------------------------------------------------------------------------------------------------------ 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_mulatta_ENSMMUP00000001339 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000379625 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000003761 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000001633 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025449 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015673 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000007386 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002088 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000000735 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000018341 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000035092 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009820 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000012280 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000015721 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000020711 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000000429 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000039929 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000044800 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000009551 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000004643 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000001873 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000020077 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007768-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP005252-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0087679 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010636-PA -------------------------------------------NRLTLHAKN---------------NGATFGN---TEINS--SSWVL--------FSTLH-KVRRLDLSYNAIDHLFV A_gambiae_AGAP000999-PA ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000045770 -----------------------------------------------------------------------CQL---KQFPTLD---LP--------------FLKSLTLTMNKGSISFK R_norvegicus_ENSRNOP00000014020 -----------------------------------------------------------------------CHL---KPFPKLS---LP--------------FLKSWTLTTNREDISFG M_domestica_ENSMODP00000024473 -----------------------------------------------------------------------CNFDIMPDLPSIS---LP--------------SLKELKVTHHKDLTTLS A_gambiae_AGAP001002-PA -------------------------------------------------------------------------------------------------FTTLP-NLMYLNISSNQLVKLQE T_guttata_ENSTGUP00000009600 -----------------------------------------------------------------------------TGNYTCMLRNTT--------Y--CSKVAFPLEVVPKDQHSCVS A_aegypti_AAEL000057-PA -------------------------------------------NHLWFAGS--------------------LYR---NEHDLEESSFSP--------FWPIRMQLRELNLRNNSIDRVDI D_melanogaster_FBpp0084432 -------------------------------------------NDIDLQQPL-------------------------LDIMLQTQINSP--------FGYMH-GLLTLNLRNNSIIFVYN P_pygmaeus_ENSPPYP00000021907 -----------------------------------------------------------------------CKF---GQFPTLE---LK--------------SLKRLTFTANKGGNAFS A_gambiae_AGAP010634-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010669-PA -------------------------------------------NSITLNEDN---------------RDVFYSN---EEINI--TSGII--------FSTLN-KVKYLDLSFNAIVKILD B_taurus_ENSBTAP00000008190 -----------------------------------------------------------------------CDF---DKFPALK---LS--------------SLKKFVFTDNKDISTFT O_cuniculus_ENSOCUP00000001909 -----------------------------------------------------------------------CEFS--ENIFFLK---LS--------------SLRRLIFTANKGVRTFP M_domestica_ENSMODP00000018871 -----------------------------------------------------------------------------TGNYTCMLRNTT--------Y--CSKVAFPLEVIQKS--SCFS T_guttata_ENSTGUP00000003444 -----------------------------------------------------------------------CHF---EDVPAQKLSLFK--------------ELRMLRINDNRNLKTFE D_rerio_ENSDARP00000055005 -----------------------------------------------------------------------IEI---EGFFGFSSMIEL--------GFLLKH-FHNVSVINATVFVIPK O_anatinus_ENSOANP00000020856 -----------------------------------------------------------------------CGF---SEVPAKSLRPLT--------------QLKELQITENDELKEFE T_guttata_ENSTGUP00000005321 -----------------------------------------------------------------------IMI---QNFHLFFDLEGM--------ESQINK-LKRLSIASSNVFMVPC P_troglodytes_ENSPTRP00000036398 -----------------------------------------------------------------------CKF---GQFPTLK---LK--------------SLKRLTFTSNKGGNAFS D_melanogaster_FBpp0075360 -------------------------------------------NQLKSIAGL---------------------F---TELPNLVWLNISGNRLEKFDYSHIPIGLQWLDVRANRITQLGN G_gorilla_ENSGGOP00000007772 -----------------------------------------------------------------------CKF---GQFPTLK---LK--------------SLKRLTFTSNKGGNAFS H_sapiens_ENSP00000363089 -----------------------------------------------------------------------CKF---GQFPTLK---LK--------------SLKRLTFTSNKGGNAFS C_familiaris_ENSCAFP00000031395 -----------------------------------------------------------------------CNL---EQFPAWE---LD--------------SLKEFVLTSNKGMNTFA E_caballus_ENSECAP00000008292 -----------------------------------------------------------------------CRI---EGFPTLE---LT--------------SLKRLVFTSNKDMKSFN A_aegypti_AAEL007619-PA -------------------------------------------NQLALHANS-------------------FIN---QELSIADNDNTP--------FQVLQ-KLRILHLRNNSISTIFQ C_familiaris_ENSCAFP00000020672 -----------------------------------------------------------------------------TGNYTCMLRNTT--------Y--CSKVAFPLEVVQKD--SCFN M_mulatta_ENSMMUP00000039787 -----------------------------------------------------------------------CKF---EQFPTLE---LE--------------SLKRLTFTANKGGNAFS E_caballus_ENSECAP00000004036 -----------------------------------------------------------------------------TGNYTCMLRNTT--------Y--CSKVAFPLEVVQKE--TCFN D_melanogaster_FBpp0080080 -------------------------------------------TQFYGAT---------------------------------------------------------------------- C_familiaris_ENSCAFP00000015327 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005325 -----------------------------------------------------------------------LSI---EEFYLFTDLHSV--------EGLLSL-LTRVTVQNTKVFLVPC O_cuniculus_ENSOCUP00000010774 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000029040 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000051260 -----------------------------------------------------------------------------TGNYTCMLRNTT--------Y--CSKVAFPLEVVQKD--SCFN E_caballus_ENSECAP00000015544 -----------------------------------------------------------------------LRI---PQFYLFRDLSSI--------YSLTER-VKRITIENSKVFLVPC A_carolinensis_ENSACAP00000015503 -----------------------------------------------------------------------VLI---KEFYMFSDMSSV--------LHFLEN-VTSLTIENVKVYMVNC H_sapiens_ENSP00000260010 -----------------------------------------------------------------------LHI---PRFYLFYDLSTL--------YSLTER-VKRITVENSKVFLVPC G_gorilla_ENSGGOP00000003012 -----------------------------------------------------------------------LHI---PRFYLFYDLSTL--------YSLTER-VKRITVENSKVFLVPC P_pygmaeus_ENSPPYP00000016910 -----------------------------------------------------------------------LHI---PRFYLFYDLSTL--------YSLTER-VKRITVENSKVFLVPC P_troglodytes_ENSPTRP00000028379 -----------------------------------------------------------------------LHI---PRFYLFYDLSTL--------YSLTER-VKRITVENSKVFLVPC M_musculus_ENSMUSP00000093843 -----------------------------------------------------------------------------TGNYTCMLRNTT--------Y--CSKVAFPLEVVQKD--SCFN M_mulatta_ENSMMUP00000020834 -----------------------------------------------------------------------LHI---PQFYSFNDLSTL--------YPLTER-VKRITVENSKVFLVPC A_gambiae_AGAP001004-PA -------------------------------------------NQLAFETLNTLPATAPDTGDQEQLTDHIPAP---DEFSLLAQDGTP--------FQHLH-QLRELDLSSNWLTAVPR M_musculus_ENSMUSP00000029623 -----------------------------------------------------------------------LHI---PQFYLFYDLSTV--------YSLLEK-VKRITVENSKVFLVPC R_norvegicus_ENSRNOP00000013025 -----------------------------------------------------------------------LHI---PQFYLFYDLSTV--------YSLLEK-VKRITVENSKVFLVPC A_aegypti_AAEL007613-PA -------------------------------------------NHLSFHDFS-------------------FVL---QEQDIADTDGTP--------FQYLE-NLQILNLRNNSITTIFR D_melanogaster_FBpp0079369 -------------------------------------------HAIWLFSGE-------------------------FDEIILHHLNSPCPYRCSCCFEWHT-GEFLINCRNLSLD-IYP D_rerio_ENSDARP00000015475 -----------------------------------------------------------------------ISN---PDIMRF---DWS--------FTWLNH-VRKFIVWNVNFNSVPC O_anatinus_ENSOANP00000007049 -----------------------------------------------------------------------------TGNYTCMLRNTT--------Y--CSKVAFPLEVVRKDPGKCVS A_aegypti_AAEL003507-PA -------------------------------------------NHLQYED---------------------------------STDKSP--------FQYLN-NLRVLNLKNNSISAILH G_gallus_ENSGALP00000015018 -----------------------------------------------------------------------MTI---LDFYLFFDLEGI--------ETQVGK-LKRLSIASSKVFMVPC C_familiaris_ENSCAFP00000012269 -----------------------------------------------------------------------LHI---PHFYSFYDMSSI--------YSLTED-VKRITVESSKVFLVPC G_gallus_ENSGALP00000015020 -----------------------------------------------------------------------LSI---EEFYLFTDLQSV--------LDLLSL-FRKVTVENTKVFLVPC B_taurus_ENSBTAP00000010530 -----------------------------------------------------------------------LHI---PQFFLFHDLSSI--------YPLTGR-VKRVTIENSKVFLVPC X_tropicalis_ENSXETP00000048303 -----------------------------------------------------------------------IAG---PHIFKY---DWT--------FTWFSK-VRNLQLSRVHLGSLPC B_taurus_ENSBTAP00000028660 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002918 -----------------------------------------------------------------------XXX---XXFYLFYDLSTL--------IARSER-VKRVTVENSKVFLVPC G_gorilla_ENSGGOP00000013642 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010425 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000007258 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000038393 -----------------------------------------------------------------------ATN---PDILTF---DQT--------FTWFSK-VSNLYIINVNFNFAQC M_domestica_ENSMODP00000002903 -----------------------------------------------------------------------------NGIYSCIAGNEN--------------KSWTISVTKKNRHGCFH G_gallus_ENSGALP00000026726 ------------------------------------------------------------------------------NAISQTLNGSE--------FYYLS-GLKYLDFSNNRIDLLYS P_pygmaeus_ENSPPYP00000004627 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000002280 -----------------------------------------------------------------------VSN---PDVLRF---DWR--------FTWFNK-IKKLSIQHVDFNSSPC O_anatinus_ENSOANP00000002290 -----------------------------------------------------------------------LSYNLLGELYNSNFDGLP--------KLKGLISLQILNLNSNRLTSLSH M_domestica_ENSMODP00000002923 -----------------------------------------------------------------------------AGFYICTFKYEP--------KGITCFLNITLEVQPKEKTPCLD M_mulatta_ENSMMUP00000029702 -----------------------------------------------------------------------------TGNYTCMLRNTT--------Y--CSKVAFPLEVVQKD--SCFN P_troglodytes_ENSPTRP00000059752 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000279992 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000024401 --------------------------------------------------------------------------------------------------------VEPPNRRNQRITTIFG E_caballus_ENSECAP00000010139 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000032224 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000072516 -----------------------------------------------------------------------------TGNYTCMLRNTT--------Y--CSKVAFPLEVVQKD--SCFN P_troglodytes_ENSPTRP00000027076 -----------------------------------------------------------------------------TGNYTCMLRNTT--------Y--CSKVAFPLEVVQKD--SCFN X_tropicalis_ENSXETP00000032922 -----------------------------------------------------------------------------TGNYTCMLRNTT--------F--CSRVAFPLEVVRKDADSCVS X_tropicalis_ENSXETP00000009956 -----------------------------------------------------------------------------CKITAATRNN----------FRYFS-NLRVLDLQDNSISLIKS P_pygmaeus_ENSPPYP00000016111 -----------------------------------------------------------------------------TGNYTCMLRNTT--------Y--CSKVAFPLEVVQKD--SCFN A_aegypti_AAEL000633-PA -------------------------------------------NYLTDISGL---------------------F---TKLPNLVWLNISDNHLEVFDYALIPTGLQWLDIHANKIAELGN G_gallus_ENSGALP00000001610 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000004210 -----------------------------------------------------------------------------XXXXXXXXXNTT--------Y--CSKVAFPLEVVQKD--SCFN X_tropicalis_ENSXETP00000057557 ------------------------------------------------------------------------FT---NDVFFFQGTHPF--------NIFAEMLVENVTFSNAGMIHFFC A_gambiae_AGAP012385-PA -------------------------------------------NYLTDIAGL---------------------F---TKLPNLLWLNISDNHLEVFDYALIPTGLQWLDIHANKITELGN A_carolinensis_ENSACAP00000000788 -----------------------------------------------------------------------------TGNYTCMLRNTT--------Y--CSKVAFPLEVVNKDPGSCVS X_tropicalis_ENSXETP00000054706 FYNCATLGAEFSMLENLRNLSIGGPLVSKVLKGDFAPIKNISLQRFSLKTMSSLWLYEKGAFSDLNTQSLCVTN---PDILRF---DWT--------FTWFNK-VSHLDIINVNFNFVPC P_troglodytes_ENSPTRP00000021076 -----------------------------------------------------------------------------TGSYFFQMENYT--------------QKWKLNVIRRNKHSCFT M_musculus_ENSMUSP00000091395 ------------------------------------------------------------------------------------------------------------------------ 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_mulatta_ENSMMUP00000001339 -----------------------------------------------------------------QVAADWTALAEEMDFEYLEI----------------------------------- H_sapiens_ENSP00000379625 -----------------------------------------------------------------QVAADWTALAEEMDFEYLEI----------------------------------- G_gorilla_ENSGGOP00000003761 -----------------------------------------------------------------QVAADWTALAEEMDFEYLEI----------------------------------- E_caballus_ENSECAP00000001633 -----------------------------------------------------------------QVAADWTALAEEMDFEYLEI----------------------------------- P_troglodytes_ENSPTRP00000025449 -----------------------------------------------------------------QVAADWTALAEEMDFEYLEI----------------------------------- P_pygmaeus_ENSPPYP00000015673 -----------------------------------------------------------------QVAADWTALAEEMDFEYLEI----------------------------------- C_familiaris_ENSCAFP00000007386 -----------------------------------------------------------------QVAADWTALAEEMGFEYLEI----------------------------------- O_cuniculus_ENSOCUP00000002088 -----------------------------------------------------------------QVAADWSALAEEMGFEYLEI----------------------------------- B_taurus_ENSBTAP00000000735 -----------------------------------------------------------------PVAADWTVLAEAMDFEYLEI----------------------------------- R_norvegicus_ENSRNOP00000018341 -----------------------------------------------------------------TAAADWTSLAEEMGFEYLEI----------------------------------- M_musculus_ENSMUSP00000035092 -----------------------------------------------------------------PVAADWTLLAEEMGFEYLEI----------------------------------- A_carolinensis_ENSACAP00000009820 -----------------------------------------------------------------AVAADWASLAEALGYEFLEI----------------------------------- O_latipes_ENSORLP00000012280 -----------------------------------------------------------------TVAADWMTVAEEMGFTYLEI----------------------------------- T_nigroviridis_ENSTNIP00000015721 -----------------------------------------------------------------AVAADWMALAEAMGFTYLEI----------------------------------- D_rerio_ENSDARP00000020711 -----------------------------------------------------------------TVAADWRTVAELMDFTYLEI----------------------------------- T_guttata_ENSTGUP00000000429 -----------------------------------------------------------------AAAADWTALAEALGCSFLEI----------------------------------- X_tropicalis_ENSXETP00000039929 -----------------------------------------------------------------VVAAGWTQLAEEMGYDYLEI----------------------------------- T_rubripes_ENSTRUP00000044800 -----------------------------------------------------------------AVAADWMALAEALGFTFLEI----------------------------------- G_gallus_ENSGALP00000009551 ---------------------------------------------------------------------------EKLGHDYLEI----------------------------------- G_aculeatus_ENSGACP00000004643 -----------------------------------------------------------------AVAADWMAVAEEMGFNYLEI----------------------------------- O_anatinus_ENSOANP00000001873 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000020077 -----------------------------------------------------------------ATVQNWKSLADLMGFSNLEI----------------------------------- A_aegypti_AAEL007768-PA -----------------------------------------------------------IFKSEDGYYRDWRGLFQVLKLDNYLV----------------------------------- A_gambiae_AGAP005252-PA -----------------------------------------------------------IFTSEDGYFRDWRGVFDVIGIPKSFL----------------------------------- D_melanogaster_FBpp0087679 -----------------------------------------------------------VLRSEEGYQRDWRGISELAKQKGFVD----------------------------------- A_gambiae_AGAP010636-PA PFQN-FMESLHTLILSHNL----ITHIGYAE------------------------LSF-LF-NLEGVNLKSNKIAH-LDFNLTSI---PSHHLFNGP----IQLNDNPFNCDCMSYPLVT A_gambiae_AGAP000999-PA ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000045770 K-V--ALPSLSYLDLSRNA----LSFSGCCSYSDLGTNSLRHLDLSFNGAIIMSANFM-GLEELQHLDFQHSTLKRVTEFSAFLS----------LEKLLYLDISYTNT----------- R_norvegicus_ENSRNOP00000014020 Q-L--ALPSLRYLDLSRNA----MSFRGCCSYSDFGTNNLKYLDLSFNGVILMSANFM-GLEELEYLDFQHSTLKKVTEFSVFLS----------LEKLLYLDISYTNT----------- M_domestica_ENSMODP00000024473 D-L--ALPNLQILDLSKNS----LNVLSCCSDKTFNTPNLKYLNLSYNAHISLSKNFM-GLENLESLDLQHTILKDHDKYPAFYS----------LINLRYLDISYTNT----------- A_gambiae_AGAP001002-PA NVFS-RLPKLKILDLSSNK----LKRLA-TD------------------------LFM-ENNHLEILDLSSNKLT-----------------RLATD----LLSENNHLEV--------- T_guttata_ENSTGUP00000009600 HSIK-PTEEMFYLEHANQK----ITCPDIDGF---------------------------YPPSVTPTVKWYLDCNSVDGFYERYP---------QGPKLVIGIVRSAY------------ A_aegypti_AAEL000057-PA AW-I-ESPELKKLDLSYNK----LSKFDNDD------------------------FKF-RSNE-MVVDLEFNQIAMLSLMAMDAT---KGS-----DGFNLFKLNHNPLNCDCQVTSFVQ D_melanogaster_FBpp0084432 DWKN-TMLQLRELDLSYNN----ISSLGYED------------------------LAF-LSQNRLHVNMTHNKIRRIALPEDVHL------GEGYNNNLVHVDLNDNPLVCDCTILWFIQ P_pygmaeus_ENSPPYP00000021907 E-V--DLPSLEFLDLSRNG----LSFKGCCSQSDFGTTSLKYLDLSFNDVITMGSNFL-GLEQLEHLDFQHSNLKQMSEFSVFLS----------LRNLIYLDISHTHT----------- A_gambiae_AGAP010634-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010669-PA PFKN-FMKGLRTLDLSHNL----ITHVGYKD------------------------LLF-PSPNIDLVNLESNKITH-LDFDRSRI---ETRHRLPKE----ILLANNPLNCDCMSYPLVT B_taurus_ENSBTAP00000008190 E-F--QLPSLQYLDLKRNH----LSFKGCCSHTDFGTTNLKHLDLSFNDVITLGSNFM-GLEQLEHLDFQHSTLKQINAFSAFLS----------LRNLRYLDISYTNI----------- O_cuniculus_ENSOCUP00000001909 E-L--NTPSLEFLDISNNG----LSLQSCCSVNSLRLTQLKHLNLSFNGVITMTSNFV-GLEQLEHLYFQHSNLRNINEFSIFLS----------LNNLLYLDISYTHI----------- M_domestica_ENSMODP00000018871 SRMK-VPREYMYMEHTLQS----LRCPNIEGF---------------------------FPSSVQPKVVWYMICEVVNNYYKVDV---------NGPELIFTYVLTSN------------ T_guttata_ENSTGUP00000003444 HKFK-GLSNLEVIDLSENR----LTFSSCCSPQFQNCPNLKHLNLSFNSNIRLTGDFT-NVKNLLYLDLQHTTLFGPGSYPVFLS----------LQRLIYLDISHTKT----------- D_rerio_ENSDARP00000055005 ETTF-LLKNLEYMDLSQNL----LTDLTIQP------------------TLYTGS--G-AYQNLNMLNVSQNVLKSLGLMSRLVT---------NLKKLKYLDLSYNSFV---------- O_anatinus_ENSOANP00000020856 QDF--CLPNLESLDLSRNR----LNFKSCCSETLFGTPRLKHLNLSFNFHIDITVNFM-GLVELQYLDLQHSKLNGPGHFSAFVL----------LTKLIYLDISYTNT----------- T_guttata_ENSTGUP00000005321 KLAR-HFSSLLYLDFHDNL----LVNKRLDE------------------T--ICE--H-SWPSLQTLNLSQNSLKSLEQTAKYIS---------RLPKLNNLDISQNNFG---------- P_troglodytes_ENSPTRP00000036398 E-V--DLPSLEFLDLSRNG----LSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFL-GLEQLEHLDFQHSNLKQMSEFSVFLS----------LRNLIYLDISHTHT----------- D_melanogaster_FBpp0075360 YFEIESELSLSTFDASYNL----LTEITASS---IPNSVEVLYLNDNQISKIQPYTFF-KKPNLTRVDLVRNRLTTLEPNALRLS------PIAEDREIPEFYIGHNAYECDCN----LD G_gorilla_ENSGGOP00000007772 E-V--DLPSLEFLDLSXXX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXX----------XXXXXXXXXXXXXX----------- H_sapiens_ENSP00000363089 E-V--DLPSLEFLDLSRNG----LSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFL-GLEQLEHLDFQHSNLKQMSEFSVFLS----------LRNLIYLDISHTHT----------- C_familiaris_ENSCAFP00000031395 D-M--KMESLEFLDLSRNR----LSFKTCCSHSDFGTTRLKHLDLSFNEIITMSSNFL-GLEQLEYLDLQHSSLKQASDFSVFLS----------LRNLRYLDISYTRT----------- E_caballus_ENSECAP00000008292 E-V--KLPSLEFLDLSRNR----LSFKSCCSEADLKTTRLKHLDLSFNDVISMSSNFM-GLEQLEHLDFQHSTLKQASDFPVFLS----------LKNLRYLDISYTNT----------- A_aegypti_AAEL007619-PA DWYI-NNLELQSLDLSFNK----LPGLSYTQ------------------------LQF-QSN--ITLNLSNNEISQVLLIDDLDL---QPYQRI--N----VDLNHNPLNCNCNALKFIQ C_familiaris_ENSCAFP00000020672 SSMK-LPLHRLYIEYGVQK----ITCPNVDGF---------------------------FPPTVKPTITWYMGCKKIKNFNNVIP---------EGMNLSFLIALVSN------------ M_mulatta_ENSMMUP00000039787 E-V--DLPSLEFLDLSRNG----LSFKGCCSQSDFGTTSLKYLDLSFNDVITMSSNFL-GLEKLEHLDFQHSNLKQMSQFSVFLS----------LRNLIYLDISHTHT----------- E_caballus_ENSECAP00000004036 SSMK-LPVQKLYLEYGIQK----ITCPNVDGF---------------------------FPPSVKPTVTWYMGCRKIEDFHNVVP---------EGMNLSFLIALVSN------------ D_melanogaster_FBpp0080080 -----------------------------------------------------------------------------------------------------LLMNYEAVVC--------- C_familiaris_ENSCAFP00000015327 -----------------------------------------------------------------LSDSTESTSSDVSQPRSKDN----------------------------------- T_guttata_ENSTGUP00000005325 RISQ-NLLSLVYLDLSANL----LGDLSLEH------------------S--ACQ--G-GWPSLQALNLSQNSLSDLERTSKSLS---------HLGNLIVLDISQNNFG---------- O_cuniculus_ENSOCUP00000010774 -----------------------------------------------------------------MPGSPESAPSDSPRTPSQAG----------------------------------- O_anatinus_ENSOANP00000029040 QLKR-SFELLEYLDLSGNI----LFDELLKN------------------S--ACD--G-AWPSLQTLNLSQNSLRYVDQTGASLS---------TLKKLINLDISQN------------- R_norvegicus_ENSRNOP00000051260 SPMR-LPVHRLYIEQGIHN----ITCPNVDGY---------------------------FPSSVKPSVTWYKGCTEIVNFHNVQP---------KGMNLSFFIPLVSN------------ E_caballus_ENSECAP00000015544 SLSR-HLKSLEYLDLSDNL----MVEEYLKN------------------S--ACE--R-AWPSLQTLILRQNHLTSLGKTGETLL---------TLKNLTKLDISKNSFH---------- A_carolinensis_ENSACAP00000015503 ILGR-HCRSMQYLDLTNNL----LLDTTLIN------------------S--FCQ--D-AWPKLQTLNVSQNALKQIEIVSRSTA---------SIINLSNLDISRNTYE---------- H_sapiens_ENSP00000260010 LLSQ-HLKSLEYLDLSENL----MVEEYLKN------------------S--ACE--D-AWPSLQTLILRQNHLASLEKTGETLL---------TLKNLTNIDISKNSFH---------- G_gorilla_ENSGGOP00000003012 LLSQ-HLKSLEYLDLSENL----MVEEYLKN------------------S--ACE--D-AWPSLQTLILRQNHLASLEKTGETLL---------TLKNLTNVDISKNSFH---------- P_pygmaeus_ENSPPYP00000016910 SLSR-HLKSLEYLDLSENL----MVEEYLKN------------------S--ACE--D-AWPSLRTLILRQNHLASLEKTGETLL---------TLKNLTNLDISKNSFH---------- P_troglodytes_ENSPTRP00000028379 LLSQ-HLKSLEYLDLSENL----IVEEYLKN------------------S--ACE--D-AWPSLQTLILRQNHLASLEKTGETLL---------TLKNLTNVDISKNSFH---------- M_musculus_ENSMUSP00000093843 SAMR-FPVHKMYIEHGIHK----ITCPNVDGY---------------------------FPSSVKPSVTWYKGCTEIVDFHNVLP---------EGMNLSFFIPLVSN------------ M_mulatta_ENSMMUP00000020834 LLSR-HLKSLEYLDLSENL----MVEEYLKN------------------S--ACE--D-AWPSLQTLILRQNHLASLGKTGETLL---------TLKNLTNLDISKNTFH---------- A_gambiae_AGAP001004-PA DLLL-NTHELQRLNLTRNN----ITSLTYAN------------------------LQF-LAPA-ITVDLRHNSIFEIDLADMERLVLLEPRNFDEQTGRARVLLNDNPLHCNCIAYAFAQ M_musculus_ENSMUSP00000029623 SFSQ-HLKSLEFLDLSENL----MVEEYLKN------------------S--ACK--G-AWPSLQTLVLSQNHLRSMQKTGEILL---------TLKNLTSLDISRNTFH---------- R_norvegicus_ENSRNOP00000013025 SFSQ-HLKSLEFLDLSENL----MVEEYLKN------------------S--ACE--G-GWPSLQSLVLSQNHLRSIRKTAEILL---------TLKNLTALDISKNSFQ---------- A_aegypti_AAEL007613-PA DWNY-NNLHLRELDLSYNN----ISTLSYLS------------------------LQF-LSQD-VRVNLTHNRISEIDLKDMEPI---ITSQRSQDDSKIYVYVNDNPLNCNCVIFSFVQ D_melanogaster_FBpp0079369 RLPN-SIPYKTTLYLDRNE----IRKLTNTESLVVAGHASIHKLHMSQNLLRELPLHL-LPENITYLDVRNNLLKYLDDGVIAFL--------EYRENITKIELSGNPWECNCKAKAFLS D_rerio_ENSDARP00000015475 DSWP-EMKSVELLDISNNQ----LLDSYIYN------------------P--LCDTRN-TLHKLDTFNVSHNRLTSLSDLASLTK---------DFVKLTTIDMSHNQLQ---------- O_anatinus_ENSOANP00000007049 PLVK-PLVKLLYEEEDLQF----INCPNIDGF---------------------------YPVNLKPVVHWFKGCKEVNNFHSVFP---------NGTSLDFTTARSSI------------ A_aegypti_AAEL003507-PA DWNY-NALQLHELDLSNNK----FTRLTYLN------------------------LHF-ISRD-IRIDLTHNGISRVDMSGFRIP---SASKQPRKTGKIWVNLNANPLDCSCSALSFVQ G_gallus_ENSGALP00000015018 RLAR-YFSSLLYLDFHDNL----LVNNRLGE------------------T--ICE--D-AWPSLQTLNLSKNSLKSLKQAARYIS---------NLHKLINLDISENNFG---------- C_familiaris_ENSCAFP00000012269 SLSQ-HLKSLEYLDLSDNL----MVEEYLRN------------------S--ACQ--H-AWPLLQTLILRQNRLKSLEKTGETLL---------TLKNLVNLDISKNNYL---------- G_gallus_ENSGALP00000015020 KLSQ-HLLSLEYLDLSANL----LGDQSLEH------------------S--ACQ--G-AWPSLQTLNLSQNSLSDLKMTGKSLF---------HLRNLNLLDISENNFG---------- B_taurus_ENSBTAP00000010530 LLSQ-HLKSLEYLDLSENL----MSEETLKN------------------S--ACK--D-AWPFLQTLVLRQNRLKSLEKTGELLL---------TLENLNNLDISKNNFL---------- X_tropicalis_ENSXETP00000048303 IAWR-QMGNIECLDVSDNR----LIGSNLYN------------------P--SCWD-G-GLPKLDTFIAANNNLQSLRLISLLTA---------KWPKLTKLDLSSNDLG---------- B_taurus_ENSBTAP00000028660 -----------------------------------------------------------------MPVSPESALSDVSHPSSPDS----------------------------------- O_cuniculus_ENSOCUP00000002918 SFSQ-HLKSLEYLDLSENL----MVEEYLKN------------------S--ACE--K-AWPSLQTLILRQNHLTSLEKTGETLL---------TLKNLTDLDISKNTFH---------- G_gorilla_ENSGGOP00000013642 -----------------------------------------------------------------RPNSPESASSDASQPTSQDS----------------------------------- M_mulatta_ENSMMUP00000010425 -----------------------------------------------------------------RPDSPESTSSNTSQPASQDR----------------------------------- A_carolinensis_ENSACAP00000007258 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000038393 DTWS-QMKNVERLDIRNNL----LLSSDLYN------------------P--SCKY-G-ELPKLHTFTAANNNLQILKPISLLTA---------NWPKLSSLDLSSNYIG---------- M_domestica_ENSMODP00000002903 P------NHLITIEADVGK----SLSINCIDD---------------------------YYQKKDHRISLFKNCSPIPGNYRSSI---------------LKNAELKD------------ G_gallus_ENSGALP00000026726 TAFK-ELKFLEILDLSNNKHYFLAEGVSHVLSFMKNLAYLKKLMMNENEISTSISTGM-ESQSLQTLEFRGNRLDIFWSDGKKEY----LSFFKNLTNLEQLDISSNMLN---------- P_pygmaeus_ENSPPYP00000004627 -----------------------------------------------------------------RPNSPESASSDASQPTSQDS----------------------------------- G_aculeatus_ENSGACP00000002280 DSWV-EMEGVEHLDISNNR----LKNEFIFN------------------Q--RCNYQG-AMPNLRTFQINTNELTSLKVVSLLTK---------EFQQLQVLDLSNNQLG---------- O_anatinus_ENSOANP00000002290 SDLP---ANLEKLDLSRNQ---------LLSPDPKLFHALKVLDLTHNSIITVNATSFPLLEKLELLELGNQTAALAIHRDAFRN----------LPNLKVLDLGYNPK----------- M_domestica_ENSMODP00000002923 SVKN----ELFLLIGSTDR----VPCPGIN-----------------------------CERDIQSEVTWYKNGTLCPRWTSTHI--------------EFTEIFYRD------------ M_mulatta_ENSMMUP00000029702 SPMK-LPVHKLYIEYGIQR----ITCPNVDGY---------------------------FPSSVKPTITWYMGCYKIQNFNNVIP---------EGMNLSFLIAFISN------------ P_troglodytes_ENSPTRP00000059752 -----------------------------------------------------------------RPNSPESTSSDASQPTSQDS----------------------------------- H_sapiens_ENSP00000279992 -----------------------------------------------------------------RPNSPESTSSDASQPTSQDS----------------------------------- C_intestinalis_ENSCINP00000024401 AYYY-EYNCIPRVCTHRQG----------------------------------------------NLDCSYTTQQSINRTRFNVL----------------------------------- E_caballus_ENSECAP00000010139 -----------------------------------------------------------------VPVSPESTPSDVSQPSSQDS----------------------------------- R_norvegicus_ENSRNOP00000032224 -----------------------------------------------------------------MPISQESHLSDGSQTATQDG----------------------------------- H_sapiens_ENSP00000072516 SPMK-LPVHKLYIEYGIQR----ITCPNVDGY---------------------------FPSSVKPTITWYMGCYKIQNFNNVIP---------EGMNLSFLIALISN------------ P_troglodytes_ENSPTRP00000027076 SPMK-LPVHKLYIEYGIQR----ITCPNVDGY---------------------------FPSSVKPTITWYMGCYKIQNFNNVIP---------EGMNLSFLIALISN------------ X_tropicalis_ENSXETP00000032922 QAVK-PEVVELPLEH-TER----LPCPDTDGF---------------------------FPVNVTPSVTWYKDCIS-ENFYERLP---------QGLNLTFIVVRSNY------------ X_tropicalis_ENSXETP00000009956 NAHI-YLRKLETLLLSGNK------ILTIQKNGLKGLVSLKELSLANNNIYKITDNTFKFVKSLRSLDLSRNQLWPLHKFQSPTP-------FLNLTQLEYLDASYQAEGN--------- P_pygmaeus_ENSPPYP00000016111 SPMK-LPVHKLYIEYGIQR----ITCPNVDGY---------------------------FPSSVKPTITWYMGCYKIQNFNNVIP---------EGMNLSFLIALISN------------ A_aegypti_AAEL000633-PA YFEIESQLALSTIDASSNQ----LTEITGSA---IPNSVELLYLNDNLISKVQSYTFF-KKPNLTRVDLFGNKITTLDPNALRIS------AVPDDRALPEFYIGGNPYQCDCN----LN G_gallus_ENSGALP00000001610 --------------------------------------------------------SSIHASSSSHSTTSHSLSSSPSSFSSSSS----------------------------------- O_cuniculus_ENSOCUP00000004210 SPMK-LPVHRLYIEYGIQK----ITCPNVDGF---------------------------FPSTVKPIITWYMXXXXXXXXXXXXX---------XXXXXXXXXXXXXX------------ X_tropicalis_ENSXETP00000057557 PPVP-SI--VRFLNLPSNR----ITDEIFLN------------------C-------S-SLNELELLNLQNNKLEQMSKISSMTL---------KMKNLKHLDLSKNGLH---------- A_gambiae_AGAP012385-PA YFEIESQLALSTIDASSNQ----LTEITGSA---IPNSVELLYLNDNLISKVQSYTFF-KKPNLTRVDLFGNKITTLDPNALRIS------AVPDDRPLPEFYIGGNPYQCDCN----LN A_carolinensis_ENSACAP00000000788 QAVK-PEEVLLYLSYTNIN----LTCPDVEGF---------------------------SPANVQPKFNWFMNCNLVHNFYERRT---------HGINLTFIIVREMY------------ X_tropicalis_ENSXETP00000054706 DAWS-QMVNVERLDISNNR----LLASNLYN------------------L--LCQY-S-ELPNLHTFIASDNNMRSLYTLSLLTL---------TWPKLATLDLTSNYLG---------- P_troglodytes_ENSPTRP00000021076 E------RQVTSKIVEVKK----FLQITCENS---------------------------YYQTLVNGTSLYKNCKKLPLENNKNP-------------TIKKNAEFED------------ M_musculus_ENSMUSP00000091395 -----------------------------------------------------------------MPISQESHLYDGSQTATQDG----------------------------------- 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_mulatta_ENSMMUP00000001339 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000379625 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000003761 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000001633 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025449 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015673 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000007386 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002088 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000000735 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000018341 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000035092 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009820 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000012280 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000015721 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000020711 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000000429 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000039929 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000044800 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000009551 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000004643 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000001873 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000020077 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007768-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP005252-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0087679 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010636-PA YLKAESYSS----KSDMLEGLQCAQPLKLLGLQLQDVQ--LEDLICAI-----------D-ASSG---FCPAECKCYKRAVDQ---CAIVNCTAS--NLTR-VPV--IHSPSI------- A_gambiae_AGAP000999-PA ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000045770 --------------------------------------------------------------------KIDFDGIFLGLTSLN-----TLKMAGN--SFKDNTLSN-VFANTT------- R_norvegicus_ENSRNOP00000014020 --------------------------------------------------------------------KIDFDGIFLGLISLN-----TLKMAGN--SFKDNTLSN-VFTNTT------- M_domestica_ENSMODP00000024473 --------------------------------------------------------------------HVKFKNIFTGMSNLK-----HLKMAGS--SFQDNILHD-IFKNLT------- A_gambiae_AGAP001002-PA -FKAD----------------------------------------------------------NQ---KCSELCKCYKRPVDQ---AAIINCTAA--NLTL-VPV--TKIPSI------- T_guttata_ENSTGUP00000009600 --------------------------------------------------------------------KGNYTCIVTFKDHGR-----TYNLTRT------------------------- A_aegypti_AAEL000057-PA FLQM--TGHVYRRWRFTVDHLRCVEPDLNRGINVVKVN--VANLLCKI-----------D-E------HCPERCSCFVRKSNE---SVLVNCEQK--NLTK-LPN--L---TN------- D_melanogaster_FBpp0084432 LVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIE--PQTLICPL-----------DFSDDPRERKCPRGCNCHVRTYDK---ALVINCHSG--NLTH-VPR--LP---N------- P_pygmaeus_ENSPPYP00000021907 --------------------------------------------------------------------RVAFNGIFNGLSSLK-----VLKMAGN--SFQENFLPD-IFTELR------- A_gambiae_AGAP010634-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010669-PA YLKAEPDSS----KSFLLKGLQCAHPSKLFGLQPQDVQ--LEDLVCEI-----------D-TFSE---FCPAECKCYKRAVDQ---CAIVNCNAA--NLTR-VPI--IHSPSN------- B_taurus_ENSBTAP00000008190 --------------------------------------------------------------------RIVFHGIFTGLVSLQ-----TLKMAGN--SFQNNLLPD-IFTELT------- O_cuniculus_ENSOCUP00000001909 --------------------------------------------------------------------RVAFRGIFDGLYSLR-----VLKMAGN--AFQDNRLLN-IFTEMT------- M_domestica_ENSMODP00000018871 --------------------------------------------------------------------SANYTCVVTYPENGR-----MFNLTRT------------------------- T_guttata_ENSTGUP00000003444 --------------------------------------------------------------------EVKSQCTFCGLNSLQ-----VLKMAGN--SFADNKLAN-NFKNLS------- D_rerio_ENSDARP00000055005 --------------------------------------------------------------------SMPEK--CSWPVTLR-----FLNLSST--KL-STLTPC-LPSSLT------- O_anatinus_ENSOANP00000020856 --------------------------------------------------------------------HIDSAGTFYGLESLQ-----VLKMAGN--TFHNRFLKD-NFRNVT------- T_guttata_ENSTGUP00000005321 --------------------------------------------------------------------EIPDV--CDWPKSLK-----YLNLSST--QI-PRVTTC-IPQTLE------- P_troglodytes_ENSPTRP00000036398 --------------------------------------------------------------------RVAFNGIFNGLSSLE-----VLKMAGN--SFQENFLPD-IFTELR------- D_melanogaster_FBpp0075360 WLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWT---SNVVDCSRA--SYEQTLPSH-IPMDSTQLYLDGN G_gorilla_ENSGGOP00000007772 --------------------------------------------------------------------XXXXXXXXXXXXXXX-----XXXXXXX--XXXXXXXXX-XXXXXX------- H_sapiens_ENSP00000363089 --------------------------------------------------------------------RVAFNGIFNGLSSLE-----VLKMAGN--SFQENFLPD-IFTELR------- C_familiaris_ENSCAFP00000031395 --------------------------------------------------------------------EVAFQGIFDGLVSLE-----VLKMADN--SFPDNSLPN-IFKGLT------- E_caballus_ENSECAP00000008292 --------------------------------------------------------------------RVVFHGIFDGLVSLQ-----VLKMAGN--SFKDNFLPN-IFREMT------- A_aegypti_AAEL007619-PA LIQSKPEHG----LQFNVDQLRCSEPPNLLDVTMDQLQ--TKDLLCDF-----------E-SAND----CPKDCQCAMRLVDY---TVIVNCSGR--GLTE-FPD--LPIPSQ------- C_familiaris_ENSCAFP00000020672 --------------------------------------------------------------------NGDYTCVVTYPENGR-----IFHLTRT------------------------- M_mulatta_ENSMMUP00000039787 --------------------------------------------------------------------RVAFNGIFDGLLSLK-----VLKMAGN--SFQENFLPD-IFTDLK------- E_caballus_ENSECAP00000004036 --------------------------------------------------------------------NGDYTCVVTYPENGR-----TFHLSRT------------------------- D_melanogaster_FBpp0080080 ----------------------------------------TNDEACQY-----------K----SAEWQCDPRCICWVQRSVG---SLIVDCRGT--SLEE-LPD--LPRTTL------- C_familiaris_ENSCAFP00000015327 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005325 --------------------------------------------------------------------EIPDV--CDWPKSLK-----YLNLSST--QI-PKVTTC-IPQTLE------- O_cuniculus_ENSOCUP00000010774 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000029040 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000051260 --------------------------------------------------------------------NGNYTCVVTYLENGR-----LFHLTRT------------------------- E_caballus_ENSECAP00000015544 --------------------------------------------------------------------SMPET--CQWPEKMK-----YLNLSSI--RI-DRLTQC-IPQTLE------- A_carolinensis_ENSACAP00000015503 --------------------------------------------------------------------AMPDF--CEWPKKLK-----YLNISSS--KV-SKVTNC-IPQSLE------- H_sapiens_ENSP00000260010 --------------------------------------------------------------------SMPET--CQWPEKMK-----YLNLSST--RI-HSVTGC-IPKTLE------- G_gorilla_ENSGGOP00000003012 --------------------------------------------------------------------SMPET--CQWPEKMK-----YLNLSST--RI-HSVTGC-IPKTLE------- P_pygmaeus_ENSPPYP00000016910 --------------------------------------------------------------------SMPET--CQWPEKMK-----YLNLSST--RI-HSVTGC-IPKTLE------- P_troglodytes_ENSPTRP00000028379 --------------------------------------------------------------------SMPET--CQWPEKMK-----YLNLSST--RI-HSVTGC-IPKTLE------- M_musculus_ENSMUSP00000093843 --------------------------------------------------------------------NGNYTCVVTYPENGR-----LFHLTRT------------------------- M_mulatta_ENSMMUP00000020834 --------------------------------------------------------------------YMPET--CQWPEKMK-----YLNLSST--RI-HSVTGC-IPKTLE------- A_gambiae_AGAP001004-PA YIQNRLATAVYDRFELVANELTCHGPEHLEGALIKDVP--TRELLCEL-----------D-TPSTAIRHCPAPCRCYIRPEDT---GVIIDCSGQ--ALTE-VPE--LPRPTT------- M_musculus_ENSMUSP00000029623 --------------------------------------------------------------------PMPDS--CQWPEKMR-----FLNLSST--GI-RVVKTC-IPQTLE------- R_norvegicus_ENSRNOP00000013025 --------------------------------------------------------------------PMPDS--CQWPGKMR-----FLNLSST--GI-QAVKTC-IPQTLE------- A_aegypti_AAEL007613-PA YLLNELDSAVYRRIQFVADDLRCSEPQNLEGVHVSKLQ--TKDLLCQL-----------D-QPGTEIKHCPANCSCHVRPLDR---GVIVNCTRQ--GLTE-IPA--LPQPTM------- D_melanogaster_FBpp0079369 FLRR-------------------HEPMEYETVLRRVEI--TDD-------------------------KCPEDCICCVDTSNSDSLAYVVDCSGK--ELSE-IPQ--LPTPT-------- D_rerio_ENSDARP00000015475 --------------------------------------------------------------------YLGNGA-CDWRKTIT-----KVIGNHN--SLTSDSFKC-LPTSVN------- O_anatinus_ENSOANP00000007049 --------------------------------------------------------------------NGIYTCIVNYLDGGR-----TFSLTRS------------------------- A_aegypti_AAEL003507-PA YIQD--PSSSIRRIQFSTRELHCLTPENLNGTKVSIVP--LADLTCQL-----------D-QP-----RCPKECHCFQRPIDL---TVVVNCTSR--GLIR-IPQ--LPYPET------- G_gallus_ENSGALP00000015018 --------------------------------------------------------------------EIPDM--CEWPENLK-----YLNLSST--QI-PKLTTC-IPSTLE------- C_familiaris_ENSCAFP00000012269 --------------------------------------------------------------------SMPET--CQWPEKLK-----CLNLSDT--RM-QSITRC-IPQTLE------- G_gallus_ENSGALP00000015020 --------------------------------------------------------------------EIPDM--CEWPENLK-----YLNLSST--QI-PKLTTC-IPSTLE------- B_taurus_ENSBTAP00000010530 --------------------------------------------------------------------SMPET--CQWPGKMK-----QLNLSST--RI-HSLTQC-LPQTLE------- X_tropicalis_ENSXETP00000048303 --------------------------------------------------------------------VYNEV--CTWIPNIT-----TLILKGN--TLKMCVFQC-LPTSVE------- B_taurus_ENSBTAP00000028660 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002918 --------------------------------------------------------------------AMPDT--CQWPERLR-----RLNLSST--RI-HSLTYC-IPQTLE------- G_gorilla_ENSGGOP00000013642 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010425 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000007258 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000038393 --------------------------------------------------------------------SEDEN--CSWTPNIT-----TFILKNN--LLTPGVFTC-LPTTVR------- M_domestica_ENSMODP00000002903 --------------------------------------------------------------------EGNYTCIFFLSNKYG-----SFNVTKT------------------------- G_gallus_ENSGALP00000026726 --------------------------------------------------------------------FLPPDVFEAMPPELK-----ILNLTSN--RLHTFNWGK-LHLLTK------- P_pygmaeus_ENSPPYP00000004627 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000002280 --------------------------------------------------------------------SAGNSRDCVWHKSIT-----RLVAHHN--PFESEALRC-LPTTLQ------- O_anatinus_ENSOANP00000002290 --------------------------------------------------------------------LFLDPDAFRGLSNLL-----ELRLFYC--GLSESVLRDRLFWALK------- M_domestica_ENSMODP00000002923 --------------------------------------------------------------------RGVYVCDYKKSINST-----WWIVRAV------------------------- M_mulatta_ENSMMUP00000029702 --------------------------------------------------------------------NGNYTCVVTYPENGR-----TFHLTRT------------------------- P_troglodytes_ENSPTRP00000059752 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000279992 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000024401 --------------------------------------------------------------------PTIPRNTYWLTLDLS-----NLQLENEKISLTQ------------------- E_caballus_ENSECAP00000010139 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000032224 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000072516 --------------------------------------------------------------------NGNYTCVVTYPENGR-----TFHLTRT------------------------- P_troglodytes_ENSPTRP00000027076 --------------------------------------------------------------------NGNYTCVVTYPENGR-----TFHLTRT------------------------- X_tropicalis_ENSXETP00000032922 --------------------------------------------------------------------QGNYTCIVTYEDSGK-----IYNLTRT------------------------- X_tropicalis_ENSXETP00000009956 --------------------------------------------------------------------IYIPASLFQGLQSLK-----VLRLQGNPSAFFRNVSFE-FLLNLT------- P_pygmaeus_ENSPPYP00000016111 --------------------------------------------------------------------NGNYTCVVTYPENGR-----TFHLTRT------------------------- A_aegypti_AAEL000633-PA WLQKNNVDSRTQPKLMDLDSIYCKLLYNRGRTYVPLVEALPNQFLCKYETHCFALCHCCDFYACDCKMECPARCTCYHDQSWT---SNVVDCSRA--GYEEQLPEQ-IPMDSTQIYLDGN G_gallus_ENSGALP00000001610 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000004210 --------------------------------------------------------------------XXXXXXXXXXXXXXX-----XXXXXXX------------------------- X_tropicalis_ENSXETP00000057557 --------------------------------------------------------------------IDNEKQ-CNWMDSLV-----FLNLSES--GLTNSVFGC-LPINLQ------- A_gambiae_AGAP012385-PA WLQKSNIDSRTQPRLMDLDSIYCKLLYNRGRTYVPLVEALPNQFLCKYDTHCFALCHCCDFYACDCKMECPKQCTCYHDQSWS---SNVVDCSRA--GYDDRLPDQ-IPMDSTQIYLDGN A_carolinensis_ENSACAP00000000788 --------------------------------------------------------------------AADYSCVATYRENGR-----DFNLTRT------------------------- X_tropicalis_ENSXETP00000054706 --------------------------------------------------------------------ALDEV--CTWTPQIT-----KLILKDN--T---------------------- P_troglodytes_ENSPTRP00000021076 --------------------------------------------------------------------QGYYSCVHFLHHNGK-----LFNITKT------------------------- M_musculus_ENSMUSP00000091395 ------------------------------------------------------------------------------------------------------------------------ 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_mulatta_ENSMMUP00000001339 ---------------------------------------------------------RQLETHADPTGRLLDAWQGR-----PGASVGRLLELL---TKLGRDDVLLELGPSIEEDCQKY H_sapiens_ENSP00000379625 ---------------------------------------------------------RQLETQADPTGRLLDAWQGR-----PGASVGRLLELL---TKLGRDDVLLELGPSIEEDCQKY G_gorilla_ENSGGOP00000003761 ---------------------------------------------------------RQLETHADPTGRLLDAWQGR-----PGASVGRLLELL---TKLGRDDVLLELGPSIEEDCQKY E_caballus_ENSECAP00000001633 ---------------------------------------------------------RQLETHTDPTGSLLDDWQGR-----PGASVGRLLELL---AKLGRDDVLVELGPSIEEDCQKY P_troglodytes_ENSPTRP00000025449 ---------------------------------------------------------RQLETHADPTGRLLDAWQGR-----PGASVGRLLELL---TKLGRDDVLLELGPSIEEDCQKY P_pygmaeus_ENSPPYP00000015673 ---------------------------------------------------------RQLETHADPTGRLLDAWQGR-----PGASVGRLLELL---TKLGRDDVLLELGPSIEEDCQKY C_familiaris_ENSCAFP00000007386 ---------------------------------------------------------RHLEMHADPTGKLLDDWQGR-----PGASVGRLLELL---TKLGRDDVLVELGPSIEEDCQKY O_cuniculus_ENSOCUP00000002088 ---------------------------------------------------------RQLETRPDPTGSLLDAWQSR-----PGASVGRLLELL---EALGRDDVLAELRPSIEEDCQKY B_taurus_ENSBTAP00000000735 ---------------------------------------------------------QQLEKYADPTSRLLDDWQRR-----PGASVGRLLELL---AKLGRDDVLMELGPSIEEDCQKY R_norvegicus_ENSRNOP00000018341 ---------------------------------------------------------REFETRPDPTRSLLDAWQGR-----SGSSVGRLLELL---ALLDREDILYELKDRIEEDCQKY M_musculus_ENSMUSP00000035092 ---------------------------------------------------------RELETRPDPTRSLLDAWQGR-----SGASVGRLLELL---ALLDREDILKELKSRIEEDCQKY A_carolinensis_ENSACAP00000009820 ---------------------------------------------------------RAFEAHADPTAQLLHDWQRRAS---PPATAGALLDAL---RRLHRHDVLADLAPAIEEDCKKY O_latipes_ENSORLP00000012280 ---------------------------------------------------------KNYEASKNPTKTVLEDWQARS----KDASVGKLLSIL---TEVERKDVVEDLRPQIDEDVRKY T_nigroviridis_ENSTNIP00000015721 ---------------------------------------------------------KNYETSVNPTVMVLEAWQARS----TEATVGKLLSVL---SGVERNDVLEDLQPILDEDVRKY D_rerio_ENSDARP00000020711 ---------------------------------------------------------KNFEKRECPFEKVLTDWETR-----PDATVANLLSIL---EKAERKDVISELKEILDDDCRKY T_guttata_ENSTGUP00000000429 ---------------------------------------------------------RRLERLPDPTAALLEEWPGRCP---GGATVGQLLAVL---RRLGRHDVLSDLAGSVEEDCKKY X_tropicalis_ENSXETP00000039929 ---------------------------------------------------------KNFERFPDCTMKLLEDWEKKC----FRATVGGLLEML---KKMERNDILTDLGPLIEADCMKH T_rubripes_ENSTRUP00000044800 ---------------------------------------------------------KNYESAINPTVKVLEDWQARS----TDATVGKLLSIL---SEVERNDVLEDLQPMIDEDVRRY G_gallus_ENSGALP00000009551 ---------------------------------------------------------RRLEALPDPTAALLEEWQSRCP---GGATVGQLLELL---RQLGRHDVLLELGGSVEEDCKKY G_aculeatus_ENSGACP00000004643 ---------------------------------------------------------KNYEGTKSPTESVLEDWQARC----TDATVGKLLSIL---EEVERRDIVEDLRPLMDEDVRKY O_anatinus_ENSOANP00000001873 ---------------------------------------------------------------------------------------------------------LSDLGPSIEEDCQKF C_intestinalis_ENSCINP00000020077 ---------------------------------------------------------LNFENERHRTRCVLEEYEVRQ----PSATIGNLCMML---DAIGRQDVLTDMEPWFARDSNMA A_aegypti_AAEL007768-PA ---------------------------------------------------------AELENHNNPTKRVLDLWENSL----KGANLKDLQNVL---GLIDRWDVLDDSNKLFYDDAEKF A_gambiae_AGAP005252-PA ---------------------------------------------------------PLVSTNPNPTRCLLDLWQSETHQCKREPNLAELQCVL---GCIDRWDILDDTSKMFERDAEQF D_melanogaster_FBpp0087679 ------------------------------------------------------------ENANNPMDLVLISWSQRSP---QTAKVGHLEHFL---GIIDRWDVCDDIQENLAKDTQRF A_gambiae_AGAP010636-PA ------------------IECNF--IE---------------LHLAQNNIR------YLSNEG-----EGWNSVRWLNVSNNRLIAL-SAESLP---KNLELLDVSGNQLTEIDAVFIQK A_gambiae_AGAP000999-PA ------------------------------------------------MIK------ELSNVG-----EGWNTIRRLNIANNSFTTL-PGDSLP---EQLELLDVSGNQLTEVDAAFIIK M_musculus_ENSMUSP00000045770 --------------------------------------NLTFLDLSKCQLE------QISWGV----FDTLHRLQLLNMSHNNLLFLDSSHYNQ-L-YSLSTLDCSFNRIETSKGI-LQH R_norvegicus_ENSRNOP00000014020 --------------------------------------NLTFLDLSKCQLE------QISRGV----FDTLYRLQLLNMSHNNLLFLDPSHYKQ-L-YSLRTLDCSFNRIETSKGI-LQH M_domestica_ENSMODP00000024473 --------------------------------------KLVSLNISYCQLE------RVSQET----MSPLHQLQVLDLSHNKLQTFDPFICMP-L-LNLQVLNCSSNSITALNGENLQE A_gambiae_AGAP001002-PA ------------------INCTF--IE---------------LHLEQNKLN------ALSNGS-----EGWNTIRRLYISNNSFTTL-PGDRLP---EQLELLDVSGNQLTEVDAAFIIK T_guttata_ENSTGUP00000009600 ------------------------------------------IKMKVV--G------SPNKALP-PQFISPNEKVVYELEAGDDLILPCEVFFT------FLKDSRTEVWWTIDGRNTVD A_aegypti_AAEL000057-PA ------------------VSLNFNDVE---------------LYLKNNSIK------SFDLPT----SCGYEKVKKFDASYNQFQNL--SSDLL---LGVKILDISNNNLSSFIELT-NL D_melanogaster_FBpp0084432 ------------------LHKNMQLME---------------LHLENNTLL------RLPSAN----TPGYESVTSLHLAGNNLTSI-DVDQLP---TNLTHLDISWNHLQMLNATVLGF P_pygmaeus_ENSPPYP00000021907 --------------------------------------NLTFLDLSQCQLE------QLSPTA----FNSLSSLQVLNMSHNNFFSLDTFPYKC-L-NSLQVLDYSLNHIMTSKKQELQH A_gambiae_AGAP010634-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010669-PA ------------------IGRNF--IE---------------LHLAQNKLH------YLSNAG-----EGWNFVRWLNVSNNSLGSL-SAESLP---EMLELLDVSGNQLTEIDAALIVK B_taurus_ENSBTAP00000008190 --------------------------------------NLTVLDLSKCQLE------QVAQTA----FHSLSSLQVLNMSHNKLLSLDTFLYEP-L-HSLRILDCSFNRIMASKEQELQN O_cuniculus_ENSOCUP00000001909 --------------------------------------SLTTLDLSSCQLE------QVYQGA----FESLPRLESLNMSHNNLLVLDTLTYKC-L-YSLQVLDLSFNHIGNITEPGQQH M_domestica_ENSMODP00000018871 ------------------------------------------VEVKVV--A------SPIYATA-PDIFSPNDHITYDKEPGEELELPCKVRFP------FLKDSRDEIWWTVDGRKPDE T_guttata_ENSTGUP00000003444 --------------------------------------HLHTLDISSCKLE------HVDQST----FDALSELKELNISNNKLMTFDPVVYQP-L-QALRVLDFSRNQLAVLLDPAREI D_rerio_ENSDARP00000055005 -----------------------------------------VLDLSENDLK------AFKQ--------RFPHLTTLILTGNRLMKLPDGKLF----PSLNTLLIQRNALRMFNQ---SS O_anatinus_ENSOANP00000020856 --------------------------------------RLLYLDISNCQLE------QVSHQA----FTSLHQLQELNISHNKLLTF-PVACAP-L-QSLKVLDCSFNLIAAPEEEALRS T_guttata_ENSTGUP00000005321 -----------------------------------------VLDVSGNNLK------EFGL--------RLPLLKELYLTRNQLKTLPGAAPI----PNLVSLSVSRNKLNSFSK---EE P_troglodytes_ENSPTRP00000036398 --------------------------------------NLTFLDLSQCQLE------QLSPTA----FNSLSSLQVLNMSHNNFFSLDTFPYKC-L-NSLQVLDYSLNHIMTSKKQELQH D_melanogaster_FBpp0075360 NFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLK------ALNGNE----FQGLDNLQELYLQHNAIATI-DTLTFT-HLYHLKILRLDHNAITSFA----VW G_gorilla_ENSGGOP00000007772 --------------------------------------XXXXXXXXXXXXX------XXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXXXX-X-XXXXXXXXXXXXXXXXXXXXXXX H_sapiens_ENSP00000363089 --------------------------------------NLTFLDLSQCQLE------QLSPTA----FNSLSSLQVLNMSHNNFFSLDTFPYKC-L-NSLQVLDYSLNHIMTSKKQELQH C_familiaris_ENSCAFP00000031395 --------------------------------------NLTILDLSRCHLE------RVSQES----FVSLPKLQEINMSHNSLLSLDTLAYEP-L-LSLQILDCSFNRIVAFKEQGQQH E_caballus_ENSECAP00000008292 --------------------------------------NLTTLDLSKCNLE------QVSQEA----FCLLPRLRVLNMSHNNLLFLDMLPYKP-L-HSLQILDCSFNRIVAFKWQELQH A_aegypti_AAEL007619-PA ------------------LHEDFNALE---------------VHVENNRLT------KLPNLT-----KH-NEITQLYARNNSIQNL-LPHNIP---SKLRIIDLSQNLLEMIDDSTLAQ C_familiaris_ENSCAFP00000020672 ------------------------------------------LTVKVVETG------SPKDALP-PQIYSPNDLVVYEKEPGEELLIPCTVYFT------FLKDARNEVWWTIDGKKPDD M_mulatta_ENSMMUP00000039787 --------------------------------------NLTFLDLSQCQLE------QLSPTA----FDTLNKLQVLNMSHNNFFSLDTFPYKC-L-PSLQVLDYSLNHIMTSNNQELQH E_caballus_ENSECAP00000004036 ------------------------------------------LTVKVV--G------SPKDALP-PQIHSPNDLVDYEKEPGEELLIPCKVFFT------FLKDSRNEIWWTIDGKKPDD D_melanogaster_FBpp0080080 ------------------LS-----TV---------------LKVGNNSLT------SLPTVS---EHSGYANVSGLFLSDNNLTSLGSGDQLP---DNLTHLDVRGNQIQSLSDEFLLF C_familiaris_ENSCAFP00000015327 ---------------------------------------------------------------------------PPPLGLSSAVSPNSPSTYVGA-------SSSSGSSGRW------- T_guttata_ENSTGUP00000005325 -----------------------------------------VLDVSGNNLK------EFGL--------RLPLLKELYLTRNQLKTLPGAAPI----PNLVSLSVSRNKLNSFSK---EE O_cuniculus_ENSOCUP00000010774 ---------------------------------------------------------------------------PAPSGLSASTSPAPPAAHEGA------CSDSGTGSGRW------- O_anatinus_ENSOANP00000029040 ---------------------------------------------NNNNLK------DFIL--------NLPRLKELYLSKNKLKTLPEGRLY----PNLLVMRISKNALNVFSR---KE R_norvegicus_ENSRNOP00000051260 ------------------------------------------MTVKVV--G------SPKDAVP-PHIYSPNDRVVYEKEPGEELVIPCKVYFS------FIMDSHNEIWWTIDGKKPDD E_caballus_ENSECAP00000015544 -----------------------------------------VLDISNNNLN------SFSL--------ILPQVKELYISRNKLKTLPDASFL----PMLLVMRISRNTINTFSK---EQ A_carolinensis_ENSACAP00000015503 -----------------------------------------VLDVSNNNLQ------DFRL--------SLPHLQELYIQNNKLTALPPPAFS----PSIRVMNIRGNKIFGFSE---QE H_sapiens_ENSP00000260010 -----------------------------------------ILDVSNNNLN------LFSL--------NLPQLKELYISRNKLMTLPDASLL----PMLLVLKISRNAITTFSK---EQ G_gorilla_ENSGGOP00000003012 -----------------------------------------ILDVSNNNLN------LFSL--------NLPQLKELYISRNKLMTLPDASLL----PXLLVLKISRNAITTFSK---EQ P_pygmaeus_ENSPPYP00000016910 -----------------------------------------ILDVSNNNLN------LFSL--------NLPQLKELYISRNKLMTLPDASLL----PMLLVLKISRNTITTFSK---EQ P_troglodytes_ENSPTRP00000028379 -----------------------------------------ILDVSNNNLN------LFSL--------NLPQLKELYISRNKLMTLPDASLL----PMLLVLKISRNAITTFSK---EQ M_musculus_ENSMUSP00000093843 ------------------------------------------VTVKVV--G------SPKDALP-PQIYSPNDRVVYEKEPGEELVIPCKVYFS------FIMDSHNEVWWTIDGKKPDD M_mulatta_ENSMMUP00000020834 -----------------------------------------ILDISNNNLN------LFSL--------NLPQLKELYISRNKLMTLPDASLL----PMLLVLKISRNTITTFSK---EQ A_gambiae_AGAP001004-PA ------------------FGYRF--IE---------------LHLENNNIS------ALPDSTTASGSSGWAEVRELYASNNSIAAL-AADQLP---RSLRLLDLSRNRLTTLDGPLAES M_musculus_ENSMUSP00000029623 -----------------------------------------VLDVSNNNLD------SFSL--------FLPRLQELYISRNKLKTLPDASLF----PVLLVMKIRENAVSTFSK---DQ R_norvegicus_ENSRNOP00000013025 -----------------------------------------VLDVSNNNLD------SFSL--------FLPRLQELYISRNKLKTLPEASLF----PVLQVMKIRENAISTFSK---DQ A_aegypti_AAEL007613-PA ------------------FGYNF--IE---------------LHVEDNNIT------ELPTEN----LTGYGKVAELYARNNAIVEL-LPENLP---SSLRILDVTQNKFVMLNQSVVES D_melanogaster_FBpp0079369 ----------------------YGQTT---------------LVFERNSLK------KWPSSL----LPGYSSVTRFYLAHNRLSDI---DQLP---DKLEYLDISNNNFSALDDRVRGF D_rerio_ENSDARP00000015475 -----------------------------------------FLDLSYSSLD------QLDMDY----FNKASELTELLLSGNKIKFIPSGWKN----RYLRTLALDGNSFGLVSM---KS O_anatinus_ENSOANP00000007049 ------------------------------------------VEVKVV--G------HPDKALP-PQMLSPMDQVVYEKEPGEELLLPCEVIFT------FLKDSPKEIWWTIDGKKTDD A_aegypti_AAEL003507-PA ------------------FGYSS--IE---------------LHIDNNSIN------ELPTEG----LSA---VSMLFARNNFISQL---HNLP---SNLRVLDVSQNRLTTLDAITIQA G_gallus_ENSGALP00000015018 -----------------------------------------VLDVSANNLQ------DFGL--------QLPFLKELYLTKNHLKTLPEATDI----PNLVAMSISRNKLNSFSK---EE C_familiaris_ENSCAFP00000012269 -----------------------------------------ILDVSNNNLE------SFSL--------ILPQLKELSISRNKLKTLPDASFL----PTLQIMRISRNTINAFSK---EQ G_gallus_ENSGALP00000015020 -----------------------------------------VLDVSANNLQ------DFGL--------QLPFLKELYLTKNHLKTLPEATDI----PNLVAMSISRNKLNSFSK---EE B_taurus_ENSBTAP00000010530 -----------------------------------------ILDVSNNNLD------SFSL--------ILPQLKELYISRNKLKTLPDASFL----PVLSVMRISRNIINTFSK---EQ X_tropicalis_ENSXETP00000048303 -----------------------------------------LLDLSYSQLE------QLDLNY----FNRATNLKELVLSHNKLNFISSDWRS----PNLQVLHLEGNSISLIDK---GT B_taurus_ENSBTAP00000028660 ---------------------------------------------------------------------------PPSLGSSSEVSPIPAPSHGSADGGGGSGNSGNSSGGRW------- O_cuniculus_ENSOCUP00000002918 -----------------------------------------ILDVSNNNLN------VFSL--------TLPRLKELYISRNMLKTLPGASLL----PMLLVMKISRNSINTFSK---EQ G_gorilla_ENSGGOP00000013642 ---------------------------------------------------------------------------PLPPSLSSVTSPSLPPTH-----------TSDSGSSRW------- M_mulatta_ENSMMUP00000010425 ----------------------------------------------------------------------------LSPSLSLVTSPSLPPTH-----------ASDSGSSRW------- A_carolinensis_ENSACAP00000007258 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000038393 -----------------------------------------YLDLSNSRLE------SLDMDY----FSNATNLKTLVLSYNKLTSISSNWSN----PFLQVLFLDNNIISIIDK---GS M_domestica_ENSMODP00000002903 ------------------------------------------FRVKV----------KDNISRVPKLFGNMTNY--VEAELGKKKTLNCTAILD---------GTDGRLYWDYMEE--ND G_gallus_ENSGALP00000026726 ---------------------------------------LITLDLSNNLLT------TVPRKL----SNCTSTLQELILRNNRITRITKYFLRG-A-IQLTYLDLSSNKIQIIKKSSFPE P_pygmaeus_ENSPPYP00000004627 ---------------------------------------------------------------------------PLPPSLSSVTSPSLPPTH-----------ASDSSSSRW------- G_aculeatus_ENSGACP00000002280 -----------------------------------------YLDLSYCELD------QLDMGY----FKRATSLKELLLSGNKIKFIPSMWKS----SSLQSLALDGNSFGLISR---AS O_anatinus_ENSOANP00000002290 --------------------------------------KLKVLSLTHNKIN------RFEKGA----FYGLDTLQVLNLSYNLLGELYNSNFDG-L-PNLKYIDLQQNHIGAIQDQTFTH M_domestica_ENSMODP00000002923 ------------------------------------------VDVIAV---------VKNTSSKPTILYPTVDMLTLEVELGKPLTLDCKAQFE------FERNFNPVIKWFVDDPGLNR M_mulatta_ENSMMUP00000029702 ------------------------------------------LTVKVV--G------SPKNAVP-PVIHSPNDHVVYEKEPGEELLIPCTVYFS------FLMDSRNEVWWTIDGKKPDD P_troglodytes_ENSPTRP00000059752 ---------------------------------------------------------------------------PLPPSLSSVTSPSLPPTH-----------ASDSGSSRW------- H_sapiens_ENSP00000279992 ---------------------------------------------------------------------------PLPPSLSSVTSPSLPPTH-----------ASDSGSSRW------- C_intestinalis_ENSCINP00000024401 ------------------------------------LTRLTTLNLTGNKLT------SIPLQG------LPRSIENINLSRNKISTLPATTLITYYLPNLKQLDLRNNSFSTIQT---QE E_caballus_ENSECAP00000010139 ---------------------------------------------------------------------------NPPQCLSSVVSPTPPPTNTGT-------SSSSSSSGRW------- R_norvegicus_ENSRNOP00000032224 ---------------------------------------------------------LSPSSGSSPRSHSSSQSQSSTPSCSSGMSPTSPPTHV--------DSSSSSSSGRW------- H_sapiens_ENSP00000072516 ------------------------------------------LTVKVV--G------SPKNAVP-PVIHSPNDHVVYEKEPGEELLIPCTVYFS------FLMDSRNEVWWTIDGKKPDD P_troglodytes_ENSPTRP00000027076 ------------------------------------------LTVKVV--G------SPKNAVP-PVIHSPNDHVVYEKEPGEELLIPCTVYFS------FLMDSRNEVWWTIDGKKPDD X_tropicalis_ENSXETP00000032922 ------------------------------------------SEVKVV--G------LLPSVCPLPLFPFYIQLFILFVSSGEEMLLSCEVFCP------FVRNSRNDVWWTVDGKKLEE X_tropicalis_ENSXETP00000009956 -----------------------------------------ELDISATVYTMTDPPISFEKEL----FKKLGQLRNLTLDNNGIQFLPEDVFTN-V-PMLEHISLRYNRLTNISE---DI P_pygmaeus_ENSPPYP00000016111 ------------------------------------------LTVKVV--E------ALQKCSA-PVIHSPNDHVVYEKEPGEELLIPCTVYFS------FLMDSRNEVWWTIDGKKPDD A_aegypti_AAEL000633-PA NFRTLSSHAFLGRKKLKVLFLNNSNVEMISNRTFYGLKELEILQLDHNQIT------GLNGFE----FVGLDRLKELLLQFNKISTI-ANHSFD-HLPNLRVLRLDHNRIVEFN----MW G_gallus_ENSGALP00000001610 ---------------------------------------------------------------------------AWSSSSSSSTSTAQPSRPA-------PVDISSSSSARW------- O_cuniculus_ENSOCUP00000004210 ------------------------------------------XXXXXX--X------XXXXXXX-XXXXXXXXXXXXXXXXXEELLIPCEVYFT------FLMDSRNEVWWTIDGKKPDD X_tropicalis_ENSXETP00000057557 -----------------------------------------ILDLSKNQIS------SIPI-E----VKNFVSLKELHLASNRLTDIPDCHNIG---NNLGVLKVDENFINLPPK---EF A_gambiae_AGAP012385-PA NFRSLSSHAFLGRKRLKILFLNGSNVETVSNRTFYGLKELEILQLDHNLLT------ALNGFE----FEGLDSLKELFLQYNRIASI-ANHTFD-HLHGLKILRLDHNRLVEFN----VW A_carolinensis_ENSACAP00000000788 ------------------------------------------FRVKVV--A------APYRSTV-PQIITPDSRVIYEFKPGVDMSLVCEVHFT------FLKDSPQEVWWTIDGRTTDE X_tropicalis_ENSXETP00000054706 ------------------------------------------------------------------------------LNQNKLKFISRDWKC----PNLQVLGLEGNSFSVIDK---GS P_troglodytes_ENSPTRP00000021076 ------------------------------------------FNITIV---------EDRSNIVPVLLGPKLNH--VAVELGKNVRLNCSALLN----------EEDVIYWMFGEENGSD M_musculus_ENSMUSP00000091395 ---------------------------------------------------------LSPSSCSSPPSHSSPESRSSPSSCSSGMSPTSPPTHV---------DSSSSSSGRW------- 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_mulatta_ENSMMUP00000001339 ILKQQQEEAEKPL---------------------------------------QVAAVDSSVPRTAE------------------------------------------------------ H_sapiens_ENSP00000379625 ILKQQQEEAEKPL---------------------------------------QVAAVDSSVPRTAE------------------------------------------------------ G_gorilla_ENSGGOP00000003761 ILKQQQEEAEKPL---------------------------------------QVAAVDSSVPRTAE------------------------------------------------------ E_caballus_ENSECAP00000001633 ILKQQQQESEKPL---------------------------------------QVAAVDSSVPRTAE------------------------------------------------------ P_troglodytes_ENSPTRP00000025449 ILKQQQEEAEKPL---------------------------------------QVAAVDSSVPRTAE------------------------------------------------------ P_pygmaeus_ENSPPYP00000015673 ILKQQQEEAEKPL---------------------------------------QVAAVDSSVPRTAE------------------------------------------------------ C_familiaris_ENSCAFP00000007386 ILKQQQEESEKPL---------------------------------------QVPAVDSSDPRTPE------------------------------------------------------ O_cuniculus_ENSOCUP00000002088 IWKQQQEESEKPL---------------------------------------QVAVVGSSVPRTPE------------------------------------------------------ B_taurus_ENSBTAP00000000735 ILKQQQEASEKPL---------------------------------------QVDSIDSSITRIND------------------------------------------------------ R_norvegicus_ENSRNOP00000018341 IRNQQKQESEKPL---------------------------------------QVARVESSVPQTKE------------------------------------------------------ M_musculus_ENSMUSP00000035092 LGKQQNQESEKPL---------------------------------------QVARVESSVPQTKE------------------------------------------------------ A_carolinensis_ENSACAP00000009820 LQRKREEQAERPV---------------------------------------QVPAVDSSFPRMSE------------------------------------------------------ O_latipes_ENSORLP00000012280 LES-LQRKSEPPL---------------------------------------QVAEVDSCVPRTPE------------------------------------------------------ T_nigroviridis_ENSTNIP00000015721 QEK-VQRDAEHPV---------------------------------------QVDEVDSCYPRTLE------------------------------------------------------ D_rerio_ENSDARP00000020711 MER-QQR---KPL---------------------------------------QVPVVDSCGPRTQE------------------------------------------------------ T_guttata_ENSTGUP00000000429 LQR-KQEEANQPL---------------------------------------QVPAVDSSVPKTSE------------------------------------------------------ X_tropicalis_ENSXETP00000039929 LEK---KNAPLPL---------------------------------------QDDKVDS-----SE------------------------------------------------------ T_rubripes_ENSTRUP00000044800 CER-LNRNPEPPV---------------------------------------QVNQVDSCFHRTLE------------------------------------------------------ G_gallus_ENSGALP00000009551 LRR-KQQEAEQPL---------------------------------------QVPAVDSSVPKTSE------------------------------------------------------ G_aculeatus_ENSGACP00000004643 CEN-QKKNAKPPL---------------------------------------QVPEVDSCVPRPTE------------------------------------------------------ O_anatinus_ENSOANP00000001873 LLK-QQEEAEKPV---------------------------------------QVAAVDSSVPRTAE------------------------------------------------------ C_intestinalis_ENSCINP00000020077 VEQSHSSMSSNFDLSPSRLLSSP------------------------TSLPIQQNAVTSSWNFGST------------------------------------------------------ A_aegypti_AAEL007768-PA LSKTAKQVSTDQL-------------------------------------------EETSIGADED------------------------------------------------------ A_gambiae_AGAP005252-PA LLREQKRAAQRGR---------------------------------------ETEATESKVSADSD------------------------------------------------------ D_melanogaster_FBpp0087679 IMKQEQRQTALVE------ACPPPPSDCF------------------ETNNNYSSSNNITVGQSVQ------------------------------------------------------ A_gambiae_AGAP010636-PA LKSST-LLNITLS--SNPWKCDC-ANPLLTFAVDNAAR-I---TDYVVLQC-IDGQ---PINSATL------------------------------------------------------ A_gambiae_AGAP000999-PA LNHTA-LRNISLS--ANPWDCHC-ENPLLAFAVDNAAR-I---TGYSTLQC-SDGQ---PINSATL------------------------------------------------------ M_musculus_ENSMUSP00000045770 F--PKSLAFFNLT--NNSVACICEHQKFLQWVKEQKQF-L---VN-VEQMTCATPV---EMNTSLV------------------------------------------------------ R_norvegicus_ENSRNOP00000014020 F--PKSLAVFNLT--NNSVACICEYQNFLQWVKDQKMF-L---VN-VEQMKCASPI---DMKASLV------------------------------------------------------ M_domestica_ENSMODP00000024473 L--SRTLISIDLS--DNPFDCVCDHQIFFQWVKEHTHL-L---NR-SKPMTCQTPS---HMKDISV------------------------------------------------------ A_gambiae_AGAP001002-PA LNHTA-LRNISLS--ANPWDCHC-ENPLLAFAVDNAAR-I---TDFSTLQC-SNGQ---PINSATL------------------------------------------------------ T_guttata_ENSTGUP00000009600 IT-DPKIKVTQSY--VDFEDKTLVRTLTVAKATAEELK---------RNYTCHARN---AKGEERS------------------------------------------------------ A_aegypti_AAEL000057-PA LNNSRQLSSVKLS--SNPWQCDCPSIDHLRVIQTTSDR-I---EDSKYMRC-SDGR---DLNLLTV------------------------------------------------------ D_melanogaster_FBpp0084432 LNRTMKWRSVKLS--GNPWMCDCTAKPLLLFTQDNFER-I---GDRNEMMC-VNAEMPTRMVELST------------------------------------------------------ P_pygmaeus_ENSPPYP00000021907 F--PSSLAFLNLT--QNDFACTCEHQSFLQWIKDQRQL-L---VE-VERMECATPS---DKQGMPV------------------------------------------------------ A_gambiae_AGAP010634-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010669-PA LNQST-LHNISLA--LNPWDCYC-ENQLLTFVVNNVAR-I---TDYYTLQC-IDGK---PINLATL------------------------------------------------------ B_taurus_ENSBTAP00000008190 L--PRSLTWLNLT--QNAFACVCEHQSFLQWVKDQRQL-L---VG-AEQMMCAEPL---DMEDMPV------------------------------------------------------ O_cuniculus_ENSOCUP00000001909 F--PSNLTLLHLT--KNAFVCDCEHQIFMQWIKDQRRL-L---VE-VEQMVCITP------PNMPV------------------------------------------------------ M_domestica_ENSMODP00000018871 TM-NITINQSETV--EIVGDKTITRILSIKKVTSDDLK---------RNYTCHARN---DKGESVK------------------------------------------------------ T_guttata_ENSTGUP00000003444 L--PDSLVLLDIS--QNLFDCSCVYLDFLKWVKEKQEL-L---QN-EELMLCHTPS---YVANVSL------------------------------------------------------ D_rerio_ENSDARP00000055005 LRSFKTLLYLEAG--ANNFVCSCKFVSFFKKDVEDLIT-L---QDGRQNYVCNTPF---TLRGNAI------------------------------------------------------ O_anatinus_ENSOANP00000020856 L--SQTLVRLDLS--QNPLDCFCDHLGFLQWVKDHRKQ-L---WK-PERMTCARPS---DLANTLV------------------------------------------------------ T_guttata_ENSTGUP00000005321 FESFRRMKLLDAS--GNNFICSCEFLSFIHHEAGISQV-L---VGWPDKYVCDSPL---AVRGAQV------------------------------------------------------ P_troglodytes_ENSPTRP00000036398 F--PSSLAFLNLT--QNDFACTCEHQSFLQWIKDQRQL-L---VE-VERMECATPS---DKQGMPV------------------------------------------------------ D_melanogaster_FBpp0075360 NFLPSYLNELRLA--SNPWTCSCEFIDKLRDYINRHEY-V---VDKLKMKCD-VISGNSTQQMVIYPGSGEPAS-------------------------LPVVQCSQTLPLG---LDNNF G_gorilla_ENSGGOP00000007772 X--XXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXX-X---XX-XXXXXXXXXX---XXXXXXX------------------------------------------------------ H_sapiens_ENSP00000363089 F--PSSLAFLNLT--QNDFACTCEHQSFLQWIKDQRQL-L---VE-VERMECATPS---DKQGMPV------------------------------------------------------ C_familiaris_ENSCAFP00000031395 F--PSNLVSLNLT--RNNFACDCEHQSFLQWVKDHRQL-L---VE-VEQMVCAKPL---DMKDMPL------------------------------------------------------ E_caballus_ENSECAP00000008292 F--PSSLASLNLT--QNDFACVCEYQSFLQWVKDQRQL-L---VE-VEHLVCAIPL---QMRGMPV------------------------------------------------------ A_aegypti_AAEL007619-PA INRSSHLETIRLS--QNQWLCDCPASSFLIFVQQNSRL-I---SDMSAVRCHPSGK---SLDSITV------------------------------------------------------ C_familiaris_ENSCAFP00000020672 TSIDVTVNESVSL--TATEDEMRTQILNIKKVSAEDLK---------RNYVCHARN---AKGEVDK------------------------------------------------------ M_mulatta_ENSMMUP00000039787 F--PSSLAFLNLT--QNDFACTCEHQSFLQWIKDQRQL-L---VE-AERMECATPS---DKQGMPV------------------------------------------------------ E_caballus_ENSECAP00000004036 TTLDVTVNESVSQ--TLTEDEWRTQILSIKKVTAEDLK---------RNYVCHARN---AKGEVDK------------------------------------------------------ D_melanogaster_FBpp0080080 LQEPNNTMTLSLS--GNPITCGCESLSLLFFVRTNPQR-V---RDIADIVCTKQKK---SFQQMEA------------------------------------------------------ C_familiaris_ENSCAFP00000015327 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005325 FESFRRMKLLDAS--GNNFICSCEFLSFIHHEAGISQV-L---VGWPDKYVCDSPL---AVRGAQV------------------------------------------------------ O_cuniculus_ENSOCUP00000010774 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000029040 FESFQKLKALEVG--GNNFICSCVFLTFLQDQQAIASV-L---TDWPENYICDSPS---HVRGQRV------------------------------------------------------ R_norvegicus_ENSRNOP00000051260 VPVDITINESVSY--SSTEDETRTQILSIKKVTPEDLK---------RNYVCHARN---AEGEAEQ------------------------------------------------------ E_caballus_ENSECAP00000015544 LDSFQKLKTLEAG--GNNFICSCEFLSFTQEEQALDQI-L---IDWPENYLCDSPS---HVRGQRV------------------------------------------------------ A_carolinensis_ENSACAP00000015503 LETFANLEMLDAR--YNSFQCTCEFLSFMQSQSEIPHI-F---IDWPNNYICDAPE---YVRGKEV------------------------------------------------------ H_sapiens_ENSP00000260010 LDSFHTLKTLEAG--GNNFICSCEFLSFTQEQQALAKV-L---IDWPANYLCDSPS---HVRGQQV------------------------------------------------------ G_gorilla_ENSGGOP00000003012 LDSFHTLKTLEAG--GNNFICSCEFLSFTQEQQALAKV-L---IDWPANYLCDSPS---HVRGQQV------------------------------------------------------ P_pygmaeus_ENSPPYP00000016910 LDSFHTLKTLEAG--GNNFICSCEFLSFTQEQQALAKV-L---IDWPANYLCDSPS---HVHGQRV------------------------------------------------------ P_troglodytes_ENSPTRP00000028379 LDSFHTLKTLEAG--GNNFICSCEFLSFTQEQQALAKV-L---IDWPANYLCDSPS---HVRGQQV------------------------------------------------------ M_musculus_ENSMUSP00000093843 VTVDITINESVSY--SSTEDETRTQILSIKKVTPEDLR---------RNYVCHARN---TKGEAEQ------------------------------------------------------ M_mulatta_ENSMMUP00000020834 LDSFHTLKTLEAG--GNNFICSCEFLSFTQEQQALAKV-L---ADWPANYLCDSPS---HVRGQRV------------------------------------------------------ A_gambiae_AGAP001004-PA LTASTTLTTVRLA--HNDWTCQCETTQLLTFAHANQRR-I---EDFGRLRC-SDGR---PLEQMTL------------------------------------------------------ M_musculus_ENSMUSP00000029623 LGSFPKLETLEAG--DNHFVCSCELLSFTMETPALAQI-L---VDWPDSYLCDSPP---RLHGHRL------------------------------------------------------ R_norvegicus_ENSRNOP00000013025 LGSFPKLETLEAG--DNHFICSCELLSFILERPALVHV-L---VDWPDSYLCDSPP---RLHGQRL------------------------------------------------------ A_aegypti_AAEL007613-PA LNSSKVLESLHLS--GNKWRCDCSSAQFMNFVQQNHKK-I---ADLGQITC-ETGE---EFSLITV------------------------------------------------------ D_melanogaster_FBpp0079369 LQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKN-I---ANASAIQCIDTGR---SLIEVEE------------------------------------------------------ D_rerio_ENSDARP00000015475 FKDMLSLRVLTAG--NNPYHCTCDLYTFIQETTSKGKVTI---TDWPNNYKCYHPE---RLLNTMV------------------------------------------------------ O_anatinus_ENSOANP00000007049 IP-DITVNQSIIT--SQIEDITIKKTLNIKKVSSDDLK---------RNYTCHARN---AKGKVEK------------------------------------------------------ A_aegypti_AAEL003507-PA LNGSLPLERLLLG--SNPWQCDCSSAPFLDFVQQTYQL-I---ADTIHITC-PNGQ---RLVAISV------------------------------------------------------ G_gallus_ENSGALP00000015018 FESFKQMELLDAS--ANNFICSCEFLSFIHHEAGIAQV-L---VGWPESYICDSPL---TVRGAQV------------------------------------------------------ C_familiaris_ENSCAFP00000012269 LDSFHRLQTLEAG--GNNFLCSCEFLSFTQEQQALAGL-L---VGWPEDYLCHSPS---YVRGQRV------------------------------------------------------ G_gallus_ENSGALP00000015020 ------------------------------------------------------PL---TVRGAQV------------------------------------------------------ B_taurus_ENSBTAP00000010530 LDSFQQLKTLEAG--GNNFICSCDFLSFTQGQQALGRV-L---VDWPDDYRCDSPS---HVRGQRV------------------------------------------------------ X_tropicalis_ENSXETP00000048303 FKDLPSLRRLTAG--NNPYDCTCDLYAFFSTLQNNDEMLL---ADWPYDYQCFHPQ---HLRDTDV------------------------------------------------------ B_taurus_ENSBTAP00000028660 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002918 LESFQKVTALEAG--GNNFICSCDFLSLTQEQPALTRV-L---PDWPESYLCDSPS---HVRGQQV------------------------------------------------------ G_gorilla_ENSGGOP00000013642 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010425 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000007258 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000038393 FNNLPQLRTLTAG--NNPYHCTCDLYSFFSDVLGKNKITI---SDWPQSYCCYHPQ---QLRNTRV------------------------------------------------------ M_domestica_ENSMODP00000002903 TNININKINSRCD---SNAMTRVSSLLEIKIVKEENLN---------MWYNCTLSS---PSITETI------------------------------------------------------ G_gallus_ENSGALP00000026726 -NIINNLRMLLLH--NNPFKCNCDAVWFVGWINQTQVA-I---PLLATDVTCAGPG---AHKGRSL------------------------------------------------------ P_pygmaeus_ENSPPYP00000004627 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000002280 FQDMPQLSQLKAG--NNPYHCTCELHSFVQDTMNKAKVNL---TDWPWNYRCYHPE---SLRNTVI------------------------------------------------------ O_anatinus_ENSOANP00000002290 L--KESLQVLDIT--HNRYICECELRDFLGWLNQSNVT-F---LGSPKDMYCVYPD---SFSGVSL------------------------------------------------------ M_domestica_ENSMODP00000002923 KELREGNKSIE----NDVEQKTIHFIAHLKEVTKKDLR---------RNFICFAQN---SVGNTTL------------------------------------------------------ M_mulatta_ENSMMUP00000029702 IPIDVTINESISH--SRTEDETRTQILSIKKVTSEDLK---------RSYVCHARS---AKGEVAK------------------------------------------------------ P_troglodytes_ENSPTRP00000059752 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000279992 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000024401 VSIFLAVTSVLLR--GNPLECNCKLRPLITWIQTNEKNEQNLSTHDLKDLICFTPK---RFEGRYI------------------------------------------------------ E_caballus_ENSECAP00000010139 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000032224 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000072516 ITIDVTINESISH--SRTEDETRTQILSIKKVTSEDLK---------RSYVCHARS---AKGEVAK------------------------------------------------------ P_troglodytes_ENSPTRP00000027076 ITIDVTINESISH--SRTEDETRTQILSIKKVTSEDLK---------RSYVCHARS---AKGEVAK------------------------------------------------------ X_tropicalis_ENSXETP00000032922 ILKGLLL---------LXGNCNKSKALNYTLLSDKVII---------VH--CYSHI---SHLVISG------------------------------------------------------ X_tropicalis_ENSXETP00000009956 LKNVPNLNYFDMY--MNTLSCSCDNYWFQNWSKCNTEV-Q---IPFIQSYKCFGLEANEMLFENQD------------------------------------------------------ P_pygmaeus_ENSPPYP00000016111 ITIDVTINESISH--SRTEDETRTQILSIKKVTSEDLK---------RSYVCHARS---AKGEVAK------------------------------------------------------ A_aegypti_AAEL000633-PA -HLPKQLTDLRLA--SNPWSCDCEYVEKFREYLKTYDF-V---RDKVKVRCSATITSGNDTAMIVGGAVNGSATGASAVIPKGVPDGSGESNGVGVGGFLIYLDNSTTLCSGAVPLDNII G_gallus_ENSGALP00000001610 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000004210 ISIDVTINESLSY--SKTEDETRTHVLSIKKVTPEDLK---------RNYVCHARN---AKGEVDK------------------------------------------------------ X_tropicalis_ENSXETP00000057557 LQNCEYVQYLSAG--QNPFQCNCDLREFVKMGVMFPKR-L---VGWPESYKCADPE---NVKGIFL------------------------------------------------------ A_gambiae_AGAP012385-PA -LLPKQLNDIRLA--FNAWSCECDYVTRFQEYLKTYDF-V---RDRHKIRCASYVSSNATIAPATQPADASQASPAEEPLP----------DGAGTGDFLVYYDNSSTLCTGAIPLENVI A_carolinensis_ENSACAP00000000788 VT-DLKFNEP-----LTVGDVKVTKTLFVSKVTEKDLR---------RNYTCFAHN---NNGTSQM------------------------------------------------------ X_tropicalis_ENSXETP00000054706 FKDLPELRRLTAG--DNPYHCTCDLYAFFTETLTERRVSL---ADWPEEYNCYHPP---HLLDTKV------------------------------------------------------ P_troglodytes_ENSPTRP00000021076 PNIHEEKEIRIMT---PEGKWHASKVLRIENIGESNLN---------VLYNCTVAS---TGGTDTK------------------------------------------------------ M_musculus_ENSMUSP00000091395 ------------------------------------------------------------------------------------------------------------------------ 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 1800 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_mulatta_ENSMMUP00000001339 -------------------------------------------------------------------LAGITTLDDPL------GHM-------PERFDAFICY--CP---------SD- H_sapiens_ENSP00000379625 -------------------------------------------------------------------LAGITTLDDPL------GHM-------PERFDAFICY--CP---------SD- G_gorilla_ENSGGOP00000003761 -------------------------------------------------------------------LAGITTLDDPL------GHM-------PERFDAFICY--CP---------SD- E_caballus_ENSECAP00000001633 -------------------------------------------------------------------LAGITTLDDPL------GQM-------PERFDAFICY--CP---------SD- P_troglodytes_ENSPTRP00000025449 -------------------------------------------------------------------LAGITTLDDPL------GHM-------PERFDAFICY--CP---------SD- P_pygmaeus_ENSPPYP00000015673 -------------------------------------------------------------------LAGITTLDDPL------GHM-------PERFDAFICY--CP---------SD- C_familiaris_ENSCAFP00000007386 -------------------------------------------------------------------RGGITMLDDPS------GQM-------PERFDAFICY--CP---------SD- O_cuniculus_ENSOCUP00000002088 -------------------------------------------------------------------LAGITTLDDPL------GQV-------PERFDAFICY--CP---------SD- B_taurus_ENSBTAP00000000735 -------------------------------------------------------------------MAGITIRDDPL------GQK-------PECFDAFICY--CP---------SD- R_norvegicus_ENSRNOP00000018341 -------------------------------------------------------------------LGGITTLDDPL------GQT-------PELFDAFICY--CP---------SD- M_musculus_ENSMUSP00000035092 -------------------------------------------------------------------LGGITTLDDPL------GQT-------PELFDAFICY--CP---------ND- A_carolinensis_ENSACAP00000009820 -------------------------------------------------------------------LRGITTQDDPM------GQF-------PEMFDAFICY--CQ---------SD- O_latipes_ENSORLP00000012280 -------------------------------------------------------------------RFGITVEDDPD------GS--------PEMFDAFICY--CQ---------DD- T_nigroviridis_ENSTNIP00000015721 -------------------------------------------------------------------RVGLTLDDDPE------GT--------PELFDAFICY--CP---------SD- D_rerio_ENSDARP00000020711 -------------------------------------------------------------------REGITLYDDPQ------GLT-------PETFDAFICY--CQ---------SD- T_guttata_ENSTGUP00000000429 -------------------------------------------------------------------LMGITIRDDPY------GSG-------TEIFDAFICY--CQ---------KD- X_tropicalis_ENSXETP00000039929 -------------------------------------------------------------------QYRITKSDDPS------GSL-------PETFDAFICY--CA---------QD- T_rubripes_ENSTRUP00000044800 -------------------------------------------------------------------RVGLTLHDDPE------GT--------PELFDAFICY--CQ---------RD- G_gallus_ENSGALP00000009551 -------------------------------------------------------------------LMGITTRDDPY------GHG-------TEMFDAFICY--CQ---------KD- G_aculeatus_ENSGACP00000004643 -------------------------------------------------------------------RIGITLQDDPE------GA--------PELFDAFICY--CQ---------KD- O_anatinus_ENSOANP00000001873 -------------------------------------------------------------------LSGITTRDDPL------GQL-------PELFDAFICY--CP---------SD- C_intestinalis_ENSCINP00000020077 ----------------------------------------------------------------------FLAQEKPPIDQGTADIQ-------NKSYDAFLLY--DA---------AD- A_aegypti_AAEL007768-PA ----------------------------------------------------------------------IITKDDTR-------QN-------KQFYDAFILF--AD---------AD- A_gambiae_AGAP005252-PA ----------------------------------------------------------------------IITRDDTS-------DH-------KQQYDAFILF--AD---------AD- D_melanogaster_FBpp0087679 ----------------------------------------------------------------------ILSDEDQR--CVQMGQP-------LPRYNACVLY--AE---------AD- A_gambiae_AGAP010636-PA -----------KELCAWLTLF-------RLYIVSAAVAVAFIGCILTIWLYVKYNLEIKVWLFKHNLLQWFAT-EEQI-------DM-------NKRYDAFISY--SH---------KD- A_gambiae_AGAP000999-PA -----------NDLCAWPTTL-------KFYI-SAAVSLVLAACLLAIWLYMKYSLEIKVWLFKHNLLQWLVT-EEQI-------DM-------DKRYDAFISY--SH---------KD- M_musculus_ENSMUSP00000045770 -----------LDFNNSTCYM-------YKTI-ISVSVVSVIVVSTVAFLIYHFYF------HL----ILIAGCKKYS-------RG-------ESIYDAFVIY--SS---------QN- R_norvegicus_ENSRNOP00000014020 -----------LDFTNSTCYI-------YKTI-ISVSVVSVLVVATVAFLIYHFYF------HL----ILIAGCKKYS-------RG-------ESIYDAFVIY--SS---------QN- M_domestica_ENSMODP00000024473 -----------QLFDDSTCHM-------KKTV-IAVSLLGIIVILLVLALVYKFYF------HL----MLLAGCKNIG-------GG-------ESIYDAFVIY--SS---------QD- A_gambiae_AGAP001002-PA -----------NELCAWTTTL-------SFYI-SSAVSLLLIVCLLAIWLYMKYSLEIKVWLFKHNLLQWLVT-EEQI-------DM-------DKRYDAFISY--SH---------KD- T_guttata_ENSTGUP00000009600 -----------QAVVRMKVVAPK----YTVEL-ACGLGATILLVVVLIVIYHVYWLEMVLF------YRAHFGTDETI-------LD-------GKEYDVYVSYARNA---------EE- A_aegypti_AAEL000057-PA -----------SDVCHVDVIT-------TIII-SMCLVI--ILILLITFVAYAYQIEIKIWLFTNNLCLRLVT-EEEI-------DK-------DKLYDAFVSY--CH---------QD- D_melanogaster_FBpp0084432 -----------NDICPAEKGV-------FIAL-AVVIALTGLLAGFTAALYYKFQTEIKIWLYAHNLLLWFVT-EEDL-------DK-------DKKFDAFISY--SH---------KD- P_pygmaeus_ENSPPYP00000021907 -----------LSL-NITCQM-------NKTI-IGVSVFSVLVVSVVAVLVYKFYF------HL----MLLAGCIKYG-------RG-------ENTYDAFVIY--SS---------QD- A_gambiae_AGAP010634-PA --------------------------------------------------------------------------------------M-------NKRYDAFISY--AH---------KD- A_gambiae_AGAP010669-PA -----------KELCGTIILS-------RLYI-SVAVSMASVGCLLCIWLYAKFNLAIKVWLFRHNLLQWLVT-EEHT-------DM-------NKRYDAFISY--SH---------KD- B_taurus_ENSBTAP00000008190 -----------LSFRNATCQL-------SKTI-ISVSVVTVLLVSVVGVLVYKFYF------HL----MLLAGCKKYG-------RG-------ESTYDAFVIY--SS---------QD- O_cuniculus_ENSOCUP00000001909 -----------LSFTNATCQI-------SKTI-ISVSVFSVLVVSFAVVLVYKFYF------PL----MLLVGRRKYG-------RG-------ESVYDAFVIY--SS---------QD- M_domestica_ENSMODP00000018871 -----------QAIVKQIVVPPR----YTVEL-ACGFAVTIVLIIILIVVYHVYWLEMVLF------YRAHFGTDETI-------LD-------GKEYDIYVSYARNA---------EE- T_guttata_ENSTGUP00000003444 -----------PSFDLSSCHI-------SAGQ-VASPVVVLFCVVVFLFLVYRYYF------QLYYSMVLLSGCKHYA-------ER-------GDTYDAFVIH--SS---------KD- D_rerio_ENSDARP00000055005 -----------DSVRLSVFECYM-----IPAV-SVLCFGIITALGLVVLTCHKLHV---IW-YLQMTKAWIQAKRKPA---VGRLPE-------ELRYDAFVSY--SQ---------HD- O_anatinus_ENSOANP00000020856 -----------LDFKPSVCEV-------KRIL-MWVSVVGVLAIAFIVVLVYKFYF------HL----MLLSGCKRYG-------PG-------GNTYDAFVIY--SS---------QD- T_guttata_ENSTGUP00000005321 -----------GAVHLSLMECHR-----SLVV-SLICVLVFLVILLLVAVGYKYHM---VW-YLRMTWAWLQAKRKPK---RAP-PK-------DVCYDAFVSY--SE---------ND- P_troglodytes_ENSPTRP00000036398 -----------LSL-NITCQM-------NKTI-IGVSVLSVLVVSVVAVLVYKFYF------HL----MLLAGCIKYG-------RG-------ENIYDAFVIY--SS---------QD- D_melanogaster_FBpp0075360 NYAEQAGGENASNATSTKMILNQPPKLDYIPI-LVAILTAFIFVMICISLVFIFRQEMRVWCHSRFGVRLFYNAQKDV-------DKN----EREKLFDAFVSY--SS---------KD- G_gorilla_ENSGGOP00000007772 -----------XXX-XXXXXX-------XXXX-XXXXXXXXXXXXXXXXXXXXXXX------XX----XXLAGCIKYG-------RG-------ENVYDAFVIY--SS---------QD- H_sapiens_ENSP00000363089 -----------LSL-NITCQM-------NKTI-IGVSVLSVLVVSVVAVLVYKFYF------HL----MLLAGCIKYG-------RG-------ENIYDAFVIY--SS---------QD- C_familiaris_ENSCAFP00000031395 -----------LSFRNATCQR-------SKTI-ISVSVFTVLMVSLVAVLAYKFYF------HL----MLLAGCKRYN-------RG-------ESTYDAFVIY--SS---------QD- E_caballus_ENSECAP00000008292 -----------LGFNNATCQI-------SKTI-VGGSVFSILMVSVIAVLVYKFYF------HL----MLLAGCKKYG-------RG-------ESIYDAFVIY--SS---------QD- A_aegypti_AAEL007619-PA -----------NELCFEDYTT-------KIVI-CFAIAVFGLLVGLISLLFFRYQTEVKVWLFTHNLFLSLIT-EEEL-------DK-------DKLYDAFISY--SH---------LD- C_familiaris_ENSCAFP00000020672 -----------AAKVKQKVIAPR----YTVEL-ACGFGATVLLVVILIVVYHVYWLEMVLF------YRAHFGTDETI-------LD-------GKEYDIYVSYARNA---------EE- M_mulatta_ENSMMUP00000039787 -----------LSL-NITCQM-------NKTI-IGVSVFSVLVVSVVAVLVYKFYF------HL----MLLAGCINYG-------RG-------ENIYDAFVIY--SS---------QD- E_caballus_ENSECAP00000004036 -----------PAKVKQKVIAPR----YTVEL-ACGFGATVLLVVILIVIYHVYWLEMVLF------YRAHFGTDETI-------LD-------GKEYDIYVSYARNA---------EE- D_melanogaster_FBpp0080080 -----------FELCPS---Y-------VLLI-SCVVGGLVIVICLLTVFYLMFQQELKIWLYNNNLCLWWVS-EEEL-------DK-------DKTYDAFISY--SH---------KD- C_familiaris_ENSCAFP00000015327 ----------------------------------------------------------------------------------------------SKDYDVCVCH--SE---------ED- T_guttata_ENSTGUP00000005325 -----------GAVHLSLMECHR-----SLVV-SLICVLVFLVILLLVAVGYKYHM---VW-YLRMTWAWLQAKRKPK---RAP-PK-------DVCYDAFVSY--SE---------ND- O_cuniculus_ENSOCUP00000010774 ----------------------------------------------------------------------------------------------SRDYDVCVCH--SE---------ED- O_anatinus_ENSOANP00000029040 -----------QDTHLPLFECHR-----ALLV-SVICCILFLIIILTVALCHHFHG---IW-YMKMTWAWLQAKRKPR---KTQ-NK-------EIYFDAFVSY--SE---------ED- R_norvegicus_ENSRNOP00000051260 -----------AAKVKQKVIPPR----YTVEL-ACGFGATVFLVVVLIVVYHVYWLEMVLF------YRAHFGTDETI-------LD-------GKEYDIYVSYARNA---------EE- E_caballus_ENSECAP00000015544 -----------QDTRLSVSECHR-----TALV-SAVCCALFLSILLTGVLCHHFHG---LW-YMKMMWAWLQAKRKPR---TAP-QR-------DICYDAFVSY--SE---------RD- A_carolinensis_ENSACAP00000015503 -----------GIAHLYLIDCHS-----TSVV-SLICILLLLIILMVAILCYKLHA---IW-YMNMIWAWLQAKRKPR---RAR-VR-------KIDYDAFVSY--SV---------QN- H_sapiens_ENSP00000260010 -----------QDVRLSVSECHR-----TALV-SGMCCALFLLILLTGVLCHRFHG---LW-YMKMMWAWLQAKRKPR---KAP-SR-------NICYDAFVSY--SE---------RD- G_gorilla_ENSGGOP00000003012 -----------QDVRLSVSECHR-----TALV-SGMCCALFLLILLTGVLCHRFHG---LW-YMKMMWAWLQAKRKPR---KAP-SR-------NICYDAFVSY--SE---------RD- P_pygmaeus_ENSPPYP00000016910 -----------QDVRLSVSECHR-----TALV-SGMCCALFLLILLTGVLCHRFHG---LW-YMKMMWAWLQAKRKPR---KAP-SR-------DICYDAFVSY--SE---------RD- P_troglodytes_ENSPTRP00000028379 -----------QDVRLSVSECHR-----TALV-SGMCCALFLLILLTGVLCHRFHG---LW-YMKMMWAWLQAKRKPR---KAP-SR-------NICYDAFVSY--SE---------RD- M_musculus_ENSMUSP00000093843 -----------AAKVKQKVIPPR----YTVEL-ACGFGATVFLVVVLIVVYHVYWLEMVLF------YRAHFGTDETI-------LD-------GKEYDIYVSYARNV---------EE- M_mulatta_ENSMMUP00000020834 -----------QDVRLSVSECHR-----AALV-SGMCCALFLLILLMGVLCHRFHG---LW-YMKMMWAWLQAKRKPR---KAP-NR-------DICYDAFVSY--SE---------RD- A_gambiae_AGAP001004-PA -----------SDLCVDRTHM-------IVLT-CVIVSVVACLVAALSLVYYTYKLELKVWLFKHGLCLWLVA-EEEL-------DR-------DKLYDAFVSY--SH---------KD- M_musculus_ENSMUSP00000029623 -----------QDARPSVLECHQ-----AALV-SGVCCALLLLILLVGALCHHFHG---LW-YLRMMWAWLQAKRKPK---KAP-CR-------DVCYDAFVSY--SE---------QD- R_norvegicus_ENSRNOP00000013025 -----------QDARPSVLECHQ-----AALV-SGVCCALLLLILLLGALCYHFHG---LW-YLRMMWAWLRAKRKPK---KAP-CR-------DLCYDAFVSY--SE---------QD- A_aegypti_AAEL007613-PA -----------NSLCNESVTT-------VITI-SVILSILGLLIGLFTVLYFVYHMEIKVWLFTHNMCLWWVS-EEEL-------DK-------DKLYDAFISY--SH---------KD- D_melanogaster_FBpp0079369 -----------TDICPSVLIY-------YTSL-AVSL----LIIALSINVFICFRQPIMIWFYEHEICLSLAA-RREL-------DE-------DKKYDAFLSF--TH---------KD- D_rerio_ENSDARP00000015475 -----------SKYSPGHLACDI-----TLVI-IISVSTTAAVVLVIMLLCYIFHV---PW-YVKATYQIIRAKYRAHKE-GLGQGV-------DYAFHAFISY--SH---------SD- O_anatinus_ENSOANP00000007049 -----------QAKVKQKVLVPR----YTVEL-ACGFGATVFLVVILIVVYHVYWLEMVLF------YRAHFGTDETI-------LD-------GKEYDIYVSYARNA---------EE- A_aegypti_AAEL003507-PA -----------VELCKERWIM-------VVAV-SLSILVLGLFVGISTAVCFAYHNEIKIWLFKRNLLMCWVT-EQEV-------DK-------DKQFDAFISY--SH---------HD- G_gallus_ENSGALP00000015018 -----------GSVQLSLMECHR-----SLLV-SLICTLVFLFILILVVVGYKYHA---VW-YMRMTWAWLQAKRKPK---RAP-TK-------DICYDAFVSY--SE---------ND- C_familiaris_ENSCAFP00000012269 -----------GTARLPASECHR-----TALV-AAVCCVLLLLVLLTAGACHHFHG---LW-YLRMLWAWLQAKRKPR---KAP-SR-------DVCYDAFVSY--SE---------HD- G_gallus_ENSGALP00000015020 -----------GSVQLSLMECHR-----SLXV-SLICTLVFLFILILVVVGYKYHA---VW-YMRMTWAWLQAKRKPK---RAP-TK-------DICYDAFVSY--SE---------ND- B_taurus_ENSBTAP00000010530 -----------QDARLSLSECHR-----AAVV-SAACCALFLLLLLTGVLCHRFHG---LW-YMKMMWAWLQAKRKPR---KAP-RR-------DICYDAFVSY--SE---------RD- X_tropicalis_ENSXETP00000048303 -----------EDYTPWRVECDV-----SLVI-TISVSTTAAIIILCMLVCWRFDV---PW-YLRMTWRIVKSKYRSK---KSNKSR-------EYNYHAFISY--SY---------SD- B_taurus_ENSBTAP00000028660 ----------------------------------------------------------------------------------------------SKDYDVCVCH--SE---------ED- O_cuniculus_ENSOCUP00000002918 -----------QDARLSVSECHR-----AAVV-SGVCCALLLLTLLAVVLCRHFHG---LW-YLKMTWAWLQAKRKPR---KAA-CR-------DVCYDAFVSY--SE---------HD- G_gorilla_ENSGGOP00000013642 ----------------------------------------------------------------------------------------------SKDYDVCVCH--SE---------ED- M_mulatta_ENSMMUP00000010425 ----------------------------------------------------------------------------------------------SKDYDVCVCH--SE---------ED- A_carolinensis_ENSACAP00000007258 ---------------------PDLPVHVFTTG-IIMAIFFSFAAVFMVILYVVFRFELVLL------YREITGKDETL-------GD-------GKLYDAFVSYLKDS----VPIYGEE- X_tropicalis_ENSXETP00000038393 -----------DIYTPGSIECNV-----GLLV-AITVSTTAVVVIACMIMCWRLDA---PW-YFRMMCHIVKSKYRSK---KANDSR-------EYNYHAFISY--SY---------SD- M_domestica_ENSMODP00000002903 -----------AYFLKKKEGPADISRHI-----FIIALVSSAAVIFLVIMCVIYRVDILLC------YRDFLRRDETL-------LD-------GKEYDAFVSYLKDC----QSENGEE- G_gallus_ENSGALP00000026726 -----------VFLDLNTCELDT-----SYFI-MYALSTSAVLCLMMFAVMSHLYF-WDVWYSYHYCTAKLKGYRRIP-------LP-------DACYDAFIAY--DN---------TDL P_pygmaeus_ENSPPYP00000004627 ----------------------------------------------------------------------------------------------SKDYDVCVCH--SE---------ED- G_aculeatus_ENSGACP00000002280 -----------SKFLPSQVACDI-----RLVV-IISVTTTAVVILTLMLICYIFDL---PW-YTKATYQIVRAKYRAHKEKAAGEGG-------AFTYHAFISY--SH---------SD- O_anatinus_ENSOANP00000002290 -----------YSVSLEDCDEEEVLRPLKFSL-FLFFTVTLLLIIISVIVYTQFRG---------FCFIGIKTVTRLV-----LGDR-------PKRYDAYLCF--SG---------KD- M_domestica_ENSMODP00000002923 -----------TIKLKQKKGV------LFTYI-LFGTTITLVAILMTSALTYRYWIEIVLL------YRTYQAKDETL-------GD-------KKEFDAFVSYARDSFGDLDSSSLNE- M_mulatta_ENSMMUP00000029702 -----------AATVKQKVPAPR----YTVEL-ACGFGATVLLVVILIVVYHVYWLEMVLF------YRAHFGTDETI-------LD-------GKEYDIYVSYARNA---------EE- P_troglodytes_ENSPTRP00000059752 ----------------------------------------------------------------------------------------------SKDYDVCVCH--SE---------ED- H_sapiens_ENSP00000279992 ----------------------------------------------------------------------------------------------SKDYDVCVCH--SE---------ED- C_intestinalis_ENSCINP00000024401 -----------INLSESEYCPVVN----LSLIGGLVGGFTALLIIIIIIVNIYLYKKRKKQ-ERRDIVQGFKDLLEKEAMNEGDPETGVGVAPVTYEYDAFVSYVSDS---------DD- E_caballus_ENSECAP00000010139 ----------------------------------------------------------------------------------------------SKDYDVCVCH--SE---------QD- R_norvegicus_ENSRNOP00000032224 ----------------------------------------------------------------------------------------------SKDYDVCVCH--SE---------ED- H_sapiens_ENSP00000072516 -----------AAKVKQKVPAPR----YTVEL-ACGFGATVLLVVILIVVYHVYWLEMVLF------YRAHFGTDETI-------LD-------GKEYDIYVSYARNA---------EE- P_troglodytes_ENSPTRP00000027076 -----------AAKVKQKVPAPR----YTVEL-ACGFGATVLLVVILIVVYHVYWLEMVLF------YRAHFGTDETI-------LD-------GKEYDIYVSYARNA---------EE- X_tropicalis_ENSXETP00000032922 -----------LA-LYHSLCSPRQIIWYITEL-ACGLGATLFLVVCLIIVYHVYWLEMVLF------YRAHFGTDETI-------GD-------GKEYDVYVSYARNA---------EE- X_tropicalis_ENSXETP00000009956 -----------FSFCTNTGYYFFLG---SFII-TFSLLTVNLLVVKLKWTVRYMYCMLEVW---------FRWKLETT-------DK-------VHKYDAYISY--CE---------DD- P_pygmaeus_ENSPPYP00000016111 -----------AAKVKQKVPAPR----YTVEL-ACGFGATVLLVVILIVVYHVYWLEMVLF------YRAHFGTDETI-------LD-------GKEYDIYVSYARNA---------EE- A_aegypti_AAEL000633-PA N----------GNLTSRKTVLSPPPIEGYIPL-LVAALCGFTVIIIMTLIMFVFRQEMRVWFHSRFGVRLFYR-NADM-------DKN----ERDKLFDAFVSY--SS---------KD- G_gallus_ENSGALP00000001610 ----------------------------------------------------------------------------------------------VKSYDVCICH--SE---------VD- O_cuniculus_ENSOCUP00000004210 -----------AAKVKQKXXXXX----XXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXX------XXXXXXXXXXX-------XX-------GKEYDIYVSYARNA---------EE- X_tropicalis_ENSXETP00000057557 -----------QDFHLSEISCNT-----SLFL-GVVLGTIFVVSIIVVSACFYFDV---PW-YIRMLFRWFRTKHRLRNVNQQDIQN-------DKLFHAFISY--SQ---------ED- A_gambiae_AGAP012385-PA N----------GNLTSRKTILSPQPIEGYIPL-LVTGLFGFSLVIILTLVLFVFRQEMRVWFHSKFGVRLFYR-NADI-------DKN----ERDKLFDAFISY--SS---------KD- A_carolinensis_ENSACAP00000000788 -----------QALVRMKAVVPR----YTLEL-ACGLGATVLLVVALTVIYHAYWLELVLF------YRAHFGTDETI-------LD-------GKEYDIYVSYARNA---------EE- X_tropicalis_ENSXETP00000054706 -----------EFYNPGRVECDV-----RLVV-AISVSTTAVVVMLCMLLCWRFDV---PW-YLRTTCSIVQSKYRSR---SFHDSR-------DYNYHAFISY--SH---------SD- P_troglodytes_ENSPTRP00000021076 -----------SFILVRKADMADIPGHVFTRG-MIIAVLILVAVVCLVTVCVIYRVDLVLF------YRHLMRRDETL-------TD-------GKTYDAFVSYLKEC----RPENGEE- M_musculus_ENSMUSP00000091395 ----------------------------------------------------------------------------------------------SKDYDVCVCH--SE---------ED- 1810 1820 1830 1840 1850 1860 1870 1880 1890 1900 1910 1920 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_mulatta_ENSMMUP00000001339 --IQFVQE-MIRQLE-Q---TNYRLKLCVSDRDVLPGTCVWSI-------AS-ELIEKRCRRMVVVVSDDYL-QSKECDFQTKFALSLSPGAHQKRLIP-IKYKAMKK--------EFPS H_sapiens_ENSP00000379625 --IQFVQE-MIRQLE-Q---TNYRLKLCVSDRDVLPGTCVWSI-------AS-ELIEKRCRRMVVVVSDDYL-QSKECDFQTKFALSLSPGAHQKRLIP-IKYKAMKK--------EFPS G_gorilla_ENSGGOP00000003761 --IQFVQE-MIRQLE-Q---TNYRLKLCVSDRDVLPGTCVWSI-------AS-ELIEKRCRRMVVVVSDDYL-QSKECDFQTKFALSLSPGAHQKRLIP-IKYKAMKK--------EFPS E_caballus_ENSECAP00000001633 --IQFVQE-MIRQLE-Q---TNYRLKLCVSDRDVLPGTCVWSI-------AS-ELIEKRCRRMVVVVSDDYL-QSKECDFQTKFALSLSPGAHQKRLIP-IKYKAMKK--------EFPS P_troglodytes_ENSPTRP00000025449 --IQFVQE-MIRQLE-Q---TNYRLKLCVSDRDVLPGTCVWSI-------AS-ELIEKRCRRMVVVVSDDYL-QSKECDFQTKFALSLSPGAHQKRLIP-IKYKAMKK--------EFPS P_pygmaeus_ENSPPYP00000015673 --IQFVQE-MIRQLE-Q---TNYRLKLCVSDRDVLPGTCVWSI-------AS-ELIEKRCRRMVVVVSDDYL-QSKECDFQTKFALSLSPGAHQKRLIP-IKYKAMKK--------EFPS C_familiaris_ENSCAFP00000007386 --IQFVQE-MIRQLE-Q---TNYRLKLCVSDRDVLPGTCVWSI-------AS-ELIEKRCRRMVVVVSDDYL-QSRECDFQTKFALSLSPGAHQKRLIP-IKYKAMKK--------EFPS O_cuniculus_ENSOCUP00000002088 --MQFVQE-MIRQLE-Q---TNYRLKLCVSDRDVLPGACVWSI-------AS-ELIEKRCRRMVVVVSDDYL-QSKECDFQTKFALSLSPGAHQKRLIP-IKYKAMKK--------EFPS B_taurus_ENSBTAP00000000735 --IEFVHE-MIRQLE-Q---TNYRLKLCVSDRDVLPGTCVWSI-------AS-ELIEKRCRRMVVVVSDEYL-QSKECDFQTKFALSLSPGAHQKRLIP-IKYKPMKK--------EFPS R_norvegicus_ENSRNOP00000018341 --IEFVQE-MIRQLE-Q---TDYRLKLCVSDRDVLPGTCVWSI-------AS-ELIEKRCRRMVVVVSDDYL-QSKECDFQTKFALSLSPGVQQKRLIP-IKYKAMKK--------DFPS M_musculus_ENSMUSP00000035092 --IEFVQE-MIRQLE-Q---TDYRLKLCVSDRDVLPGTCVWSI-------AS-ELIEKRCRRMVVVVSDDYL-QSKECDFQTKFALSLSPGVQQKRLIP-IKYKAMKK--------DFPS A_carolinensis_ENSACAP00000009820 --LPFVQE-MIQELE-H---TDHKVKLCVFDRDVLPGTCVWSI-------TS-ELIERRCRKMVVVISDDYL-ESEECDFQTKFALSLSPGARQKRLIP-VKCKTMKK--------EFPS O_latipes_ENSORLP00000012280 --FHFVCE-MIRELE-Q---TDHKLKLCVFDRDVLPGSCVWTI-------TS-ELIEKRCKRMVVVISDEYL-ESDACDFQTKFALSLCPGARNKRLIP-VIYKTMKK--------PFPT T_nigroviridis_ENSTNIP00000015721 --FEFVHV-MIRELE-Q---TDFKLKLCVFDRDVLPGSCVWTI-------TS-ELIEKRCKRMVVVISDEYL-DSEACDFQTKFALSLSPGARNKRLIP-VKYKSMTK--------PFPS D_rerio_ENSDARP00000020711 --IQFVHE-MIKQLE-H---TEYNLKLCVFDRDVLPGTCVWTI-------AS-ELIEKRCKRMVVVISDDYL-DSDACDFQTKFALSLCPGARTKRLIP-VVYKSMKR--------PFPS T_guttata_ENSTGUP00000000429 --LQFVQE-MIRELE-Q---TEFKLKLCVFDRDVLPGACVWSI-------SG-ELIERRCRRMVVVVSDDYL-ESDECDFQTKFALSLSPGARHKRLIP-VKYKSMKN--------EFPS X_tropicalis_ENSXETP00000039929 --ISFVQE-MISRLE-Q---TDYKLKLCVFDRDVLPGTCLWSI-------TS-ELIEHRCRKMVVIISDDYL-DSSECDFQTKFALSLGPGAREKRLIP-VKYKPMKR--------PFPS T_rubripes_ENSTRUP00000044800 --FEFVQE-MIRQLE-E---TDFKLKLCVFDRDVLPGSCVWTI-------TS-ELIEKRCKRMVVVISDEYL-DSEACDFQTKFALSLSPGARNKRLIP-VKYKSMSK--------PFPS G_gallus_ENSGALP00000009551 --LQFVQE-MIRELE-Q---TEFKLKLCVFDRDVLPGTCVWSI-------SG-ELIERRCRRMVVVISDDYL-ESDECDFQTKFALSLSPGARLKRLIP-VKCKTMKN--------EFPS G_aculeatus_ENSGACP00000004643 --FAFVRE-MIRELE-Q---TEYKLKLCVFDRDVLPGSCVWTI-------TS-ELIEKRCKRMVVVISDEYL-DSDACDFQTKFALSLCPGAQSKRLIP-VMYKPMTK--------PFPS O_anatinus_ENSOANP00000001873 --IQFVHE-MIRQLE-Q---TEFGLKLCVSDRDVLPGTCVWSI-------TS-ELIEKRCRRMVVVISDDYL-QSNECDFQTKFALSLCPGARQKRLIP-VKYKAMKR--------DFPS C_intestinalis_ENSCINP00000020077 --SKFIREEFLPKVE-----TDAKIKLFVPDRDLDAGVQAFQS-------QL-EFMLRRCSKLVVILSDEFL-KNPDSQWSLNVGVSLDPGSKGKKIIP-VIYKKITE----------PN A_aegypti_AAEL007768-PA --IEFATK-IMERME------ERKLKICIKDRDLLAGITFEHE-------AIIKLISERCRRLVVVISREFL-KSPLNNFFVMYAQALQIEQKKRKIIP-CVYERL----------ELPA A_gambiae_AGAP005252-PA --IEFASK-MVDKLE------ARGLQLCLRDRDILGGSNFEHE-------VISRLISERCRRVVVIISKAFL-ASPLNDFTVTFAQALQIEQKARKVIP-CVYDRC----------ELPP D_melanogaster_FBpp0087679 --IDHATE-IMNNLE-S---ERYNLRLFLRHRDMLMGVPFEHV-------QLSHFMATRCNHLIVVLTEEFL-RSPENTYLVNFTQKIQIENHTRKIIP-ILYKT---------DMHIPQ A_gambiae_AGAP010636-PA --EEFVTKELLPKLE-S---EELNFKICWHVRDFMPGEMIANE-------IT-KAVE-ESRRTIIILSLNYL-ESVWGQIEFSTAYLQSLADKCNRVIP-IIYQDIGD--IEQLDPQLQA A_gambiae_AGAP000999-PA --EEFVTDQLLPRLE-S---EELNFKICWHVRDFMPGEMIATQ-------IT-KAVE-DSRRTIIILSLNYL-ESVWGQMEFNTAYLQSLEDKRNRVIP-IIYQDIGD--IDQLDPELRA M_musculus_ENSMUSP00000045770 --EDWVRNELVKNLE-E---GVPRFHLCLHYRDFIPGVAIAAN-------IIQEGFH-KSRKVIVVVSRHFI-QSRWCIFEYEIAQTWQFLSSRSGIIF-IVLEKVEK-SLLRQQVELYR R_norvegicus_ENSRNOP00000014020 --EDWVRNELVKNLE-E---GVPRFQLCLHYRDFIPGVAIAAN-------IIQEGFH-KSRKVIVVVSRHFI-QSRWCIFEYEIAQTWQFLSSRSGIIF-IVLEKVEK-SLLRQQVELYR M_domestica_ENSMODP00000024473 --EDWVRKELVKNLE-E---GVPSFQLCLHYRDFIPGVAIAAN-------IIQEGFH-KSRKVIVVISEHFI-QSRWCKFEYEIAQTWQFLSSQAGIIF-IILQKVEK-SLLRQQMELYR A_gambiae_AGAP001002-PA --EEFVTDQMLPRLE-S---EELNFKICWHVRDFMPGEMIASQ-------IT-KAVE-DSRRTIIILSHNYL-ESVWGQMEFSTAYLQSLEDKRNRVIP-IIYQDIGD--IDQLDPELQA T_guttata_ENSTGUP00000009600 --EEFVLLTLRGVLE-----NEFGYKLCIFDRDSLPGGNTTEA-------VF-DFIQ-RSRRMIVVLSPDYLTEKSISLLEFKLGIMCQNAIAT-KLIV-VEYRPLQC--TH--PSIL-Q A_aegypti_AAEL000057-PA --EEFVSSTLVPRLE-T---APMNLKVCWHMRDWNPGEVITTQ-------IV-HSIE-NSRRTIVVLSRDFL-ESSWGQLEFRTAHVSSMAEKRVRVII-IIYGDLGD--EDRIDSEMKA D_melanogaster_FBpp0084432 --QSFIEDYLVPQLE-H---GPQKFQLCVHERDWLVGGHIPEN-------IM-RSVA-DSRRTIIVLSQNFI-KSEWARLEFRAAHRSALNEGRSRIIV-IIYSDIGD--VEKLDEELKA P_pygmaeus_ENSPPYP00000021907 --EDWVRNELVKNLE-E---GVPTFQLCLHYRDFIPGVAIAAN-------IIHEGFH-KSRKVIVVVSQHFI-QSRWCIFEYEIAQTWQFLSSRAGIIF-IVLQKVEK-TLLRQQVELYR A_gambiae_AGAP010634-PA --EEFVTKELLPRFE-S---EELNFKICWHVRDFMPGEMIANE-------TT-KAVE-ESRRTIIILSLNYL-ESVWGQIEFSTAYLQSLADKCNRVIP-IIYQDIGD--IEQLDPQLQA A_gambiae_AGAP010669-PA --EDFVTKELLPRLE-S---EELNFKICWHVRDFVPGEMIANELLYYSFQIA-KAVE-ESRRTIIILSLNYF-ESMWGQMEFSAAYLQSLVDKHNRVIP-IIYQDIGD--IDQLDPQLRA B_taurus_ENSBTAP00000008190 --EDWVRNELVKNLE-E---GVPPFQLCLHYRDFIPGVAIAAN-------IIQEGFH-KSRKVIVVVSQHFI-QSRWCIFEYEIAQTWQFLSSRAGIIF-IVLQKLEK-SLLRQQVELYR O_cuniculus_ENSOCUP00000001909 --EDWVRNELVKNLE-E---GVPPFRLCLHYRDFIPGVAIAAN-------IIQEGFH-KSRKVIVVVSQHFI-QSRWCIFEYEIAQTWQFLSSHAGIIF-IVLQKVEK-SLLRQRVELYR M_domestica_ENSMODP00000018871 --EEFVLLTLRGVLE-----NEFGYKLCIFDRDSLPGGNTVEA-------VF-DFIQ-RSRRMIVVLSPDYLTEKSISLLEFKLGVLCQNSIAT-QLVV-VEYRPLEQ--PH--PSIL-Q T_guttata_ENSTGUP00000003444 --QEWVMKELVEPLE-G---GTPRFRLCLYYRDFLPGVPIVTN-------IIEEGFL-SSRNVIAVISADFL-QSKWCSFEFDIAQSWQLVEGKAGLIM-IVLEDVNK-ALLRQRLGLSR D_rerio_ENSDARP00000055005 --AEWVEEILVAELE-D---TQPSFSLCLHKRDFRPGRWIVDN-------II-DSIE-KSYRTLFVLSEHFV-SSEWCRYELDFSHFRIMDEHNDSAVL-VLLEPIKKETIPKRFCKLRK O_anatinus_ENSOANP00000020856 --EEWVRNELVKNLE-E---GVPPFQLCLHYRDFMPGVAITSN-------IIQEGFH-KSRKVIVVVSKHFM-ESRWCSFEFEIAQTWQFLESQAGIIL-IVLQKVDK-SQLQRRMGLSR T_guttata_ENSTGUP00000005321 --SDWVENTMVRELE-Q---ACPPFRLCLHKRDFVPGKWIVDN-------II-DSIE-KSRKTLFVLSEHFV-QSEWCKYELDFSHFRLFDENNDAAIL-VLLEPIQSKAIPKRFCKLRK P_troglodytes_ENSPTRP00000036398 --EDWVRNELVKNLE-E---GVPPFQLCLHYRDFIPGVAIAAN-------IIHEGFH-KSRKVIVVVSQHFI-QSRWCIFEYEIAQTWQFLSSRAGIIF-IVLQKVEK-TLLRRQVELYR D_melanogaster_FBpp0075360 --ELFVNEELAPMLE-M---GEHRYKLCLHQRDFPVGGYLPET-------IV-QAID-SSRRTIMVVSENFI-KSEWCRFEFKSAHQSVLRDRRRRLIV-IVLGEVPQ---KELDPDLRL G_gorilla_ENSGGOP00000007772 --EDWVRNELVKNLE-E---GVPPFQLCLHYRDFIPGVAIAAN-------IIHEGFH-KSRKVIVVVSQHFI-QSRWCIFEYEIAQTWQFLSSRAGIIF-IVLQKVEK-TLLRQQVELYR H_sapiens_ENSP00000363089 --EDWVRNELVKNLE-E---GVPPFQLCLHYRDFIPGVAIAAN-------IIHEGFH-KSRKVIVVVSQHFI-QSRWCIFEYEIAQTWQFLSSRAGIIF-IVLQKVEK-TLLRQQVELYR C_familiaris_ENSCAFP00000031395 --EDWVRNELVKNLE-E---GVPPFQLCLHYRDFIPGVAIAAN-------IIQEGFY-KSRKVIVVVSQHFI-QSRWCIFEYEIAQTWQFLSSRAGIIF-IVLQKVEK-SLLRQQVELYR E_caballus_ENSECAP00000008292 --EDWVRNELVKNLE-E---GVPPFQLCLHYRDFIPGVAIAAN-------IIQEGFH-KSRKVIVVVSQHFI-QSRWCIFEYEIAQTWQFLSSRAGIIF-IVLHKLEK-SLLRQQVELYR A_aegypti_AAEL007619-PA --EEFIVDELIPKLE-N---DPMNFKTCWHVRDFMPGEMIMTQ-------IV-KSIE-ASRRTVIVLSKNFL-ESSWAKQEFRQAHVQSMEDNRVRVIV-VIYEDIGD--IDSLDGELKA C_familiaris_ENSCAFP00000020672 --EEFVLLTLRGVLE-----NEFGYKLCIFDRDSLPGGNTVEA-------VF-DFIQ-RSRRMIVVLSPDYVTEKSISMLEFKLGIMCQNSIST-KLIV-VEYRPLEH--PH--PSIL-Q M_mulatta_ENSMMUP00000039787 --EDWVRNELVKNLE-E---GVPPFQLCLHYRDFIPGVAIAAN-------IIHEGFH-KSRKVIVVVSQHFI-QSRWCIFEYEIAQTWQFLSSRAGIIF-IVLQKVEK-TLLRQQVELYR E_caballus_ENSECAP00000004036 --EEFVLLTLRGVLE-----NEFGYKLCIFDRDSLPGGNTVEA-------VF-DFIQ-RSRRMIVVLSPDYVTEKSISMLEFKLGVMCQNSIAT-KLIV-VEYRPLEH--PH--PSIL-Q D_melanogaster_FBpp0080080 --EELISK-LLPKLE-S---GPHPFRLCLHDRDWLVGDCIPEQ-------IV-RTVD-DSKRVIIVLSQHFI-DSVWARMEFRIAYQATLQDKRKRIII-ILYRELEH--MNGIDSELRA C_familiaris_ENSCAFP00000015327 --LVAAQE-LVSYLE-G---SAASLRCFLQLRDSTPGGAIVSE-------LC-HALS-SSHCRVLLITPGFL-QDPWCKYQMLQALSEAPGAEGRTI---PLMSGLTR-------AAYPA T_guttata_ENSTGUP00000005325 --SDWVENTMVRELE-Q---ACPPFRLCLHKRDFVPGKWIVDN-------II-DSIE-KSRKTLFVLSEHFV-QSEWCKYELDFSHFRLFDENNDAAIL-VLLEPIQSKAIPKRFCKLRK O_cuniculus_ENSOCUP00000010774 --LAAAQE-LVSYLE-G---SAASLRCFLQLRDAAPGGAIVSE-------LC-QALS-SSHCRVLLITPGFL-RDPWCRYQMLQALSEAPGAEGRTI---PLLSGLSR-------AAYPP O_anatinus_ENSOANP00000029040 --SYWVENLMVQELE-H---SNPPFRLCLHKRDFVPGKWIIDN-------II-DSIE-KSHKTLFVLSENFV-KSEWCKYELDFSHFRLFDENNDSAIL-ILLEPIEKKAIPQRFCKLRK R_norvegicus_ENSRNOP00000051260 --EEFVLLTLRGVLE-----NEFGYKLCIFDRDSLPGGNTVEA-------VF-DFIQ-RSRRMIVVLSPDYVTEKSISMLEFKLGVMCQNSIAT-KLIV-VEYRPLEQ--PH--PGIM-Q E_caballus_ENSECAP00000015544 --SYWVENLMVQELE-H---FNPPFKLCLHKRDFIPGKWIIDN-------II-DSIE-KSHKTIFVLSENFV-KSEWCKYELDFSHFRLFDENNDAAIL-ILLEPIDKKAIPQRFCKLRK A_carolinensis_ENSACAP00000015503 --SEWVENVMVRELE-Q---AHPPFKLCLHKRDFLPGKWIVDN-------II-DSIE-RSSKTLFVLSQHFV-QSEWCKYELDFSHFRLFDENNDSAIL-ILLEPIPAETVPRRFCKLRK H_sapiens_ENSP00000260010 --AYWVENLMVQELE-N---FNPPFKLCLHKRDFIPGKWIIDN-------II-DSIE-KSHKTVFVLSENFV-KSEWCKYELDFSHFRLFDENNDAAIL-ILLEPIEKKAIPQRFCKLRK G_gorilla_ENSGGOP00000003012 --AYWVENLMVQELE-N---FNPPFKLCLHKRDFIPGKWIIDN-------II-DSIE-KSHKTVFVLSENFV-KSEWCKYELDFSHFRLFDENNDAAIL-ILLEPIEKKAIPQRFCKLRK P_pygmaeus_ENSPPYP00000016910 --AYWVENLMVQELE-N---FNPPFKLCLHKRDFIPGKWIIDN-------II-DSIE-KSHKTVFVLSENFV-KSEWCKYELDFSHFRLFDENNDAAIL-ILLEPIEKKAIPQRFCKLRK P_troglodytes_ENSPTRP00000028379 --AYWVENLMVQELE-N---FNPPFKLCLHKRDFIPGKWIIDN-------II-DSIE-KSHKTVFVLSENFV-KSEWCKYELDFSHFRLFDENNDAAIL-ILLEPIEKKAIPQRFCKLRK M_musculus_ENSMUSP00000093843 --EEFVLLTLRGVLE-----NEFGYKLCIFDRDSLPGGNTVEA-------VF-DFIQ-RSRRMIVVLSPDYVTEKSISMLEFKLGVMCQNSIAT-KLIV-VEYRPLEQ--PH--PGIM-Q M_mulatta_ENSMMUP00000020834 --AYWVENLMVQELE-N---FNPPFKLCLHKRDFIPGKWIIDN-------II-DSIE-KSHKTVFVLSENFV-KSEWCKYELDFSHFRLFDENNDAAIL-VLLEPIEKKAIPQRFCKLRK A_gambiae_AGAP001004-PA --EAFITEHLVPTLE-R---DPMNFKLCWHVRDWTPGEMISSQ-------IS-SSVE-QSRRTIIVLSSSFL-ESLWGQLEFRTAHLQSMAERRNRLII-IIYGDIGN--IYDLEPELRA M_musculus_ENSMUSP00000029623 --SHWVENLMVQQLE-N---SDPPFKLCLHKRDFVPGKWIIDN-------II-DSIE-KSHKTVFVLSENFV-RSEWCKYELDFSHFRLFDENNDAAIL-VLLEPIERKAIPQRFCKLRK R_norvegicus_ENSRNOP00000013025 --SYWVENLMVQQLE-N---SDPPFKLCLHKRDFVPGKWIIDN-------II-DSIE-KSHKTVFVLSENFV-RSEWCKYELDFSHFRLFDENNDAAIL-VLLEPIEKKAIPQRFCKLRK A_aegypti_AAEL007613-PA --EEFITEHLVPTLE-K---EPMNFKTCWHVRDWMPGELIPTQ-------IA-KSVE-DSRRTIVVLSTNFL-ESVWGRMEFRTAHLTSMEEKRARVIV-IIYGDIGS--IEDLDPELKA D_melanogaster_FBpp0079369 --EDLI-EEFVDRLE-N---GRHKFRLCFYLRDWLVGESIPDC-------IN-QSVK-GSRRIIILMTKNFL-KSTWGRLEFRLALHATSRDRCKRLIV-VLYPDVEH--FDDLDSELRA D_rerio_ENSDARP00000015475 --ADWVRNHLLPCLE-N---VKPPYRLCIHERDFIPGKWIIDN-------II-ENIE-NSRKVIFVLSHNFV-NSEWCNYELYFAQQRAIGKTFSDVIL-VVKEPIDPTSLPSKFCKLKR O_anatinus_ENSOANP00000007049 --EEFVLLTLRGVLE-----NEFGYKLCIFDRDSLPGGNTVEA-------VF-DFIQ-RSRRMIVVLSPDYVTEKSISMLEFKLGVMCQNSIAT-QLIV-VEYQPLQH--PH--PGVL-Q A_aegypti_AAEL003507-PA --EDFVANHLVPTLE-Q---PPMNFRTCWHVRDWTPGELITEQ-------MT-RSIS-ESRRTIVVLSKGFL-ESVWARMEFRTAHLNSIAERRSRVIV-ILYEHFGD--IEQLDADLKA G_gallus_ENSGALP00000015018 --SNWVENIMVQQLE-Q---ACPPFRLCLHKRDFVPGKWIVDN-------II-DSIE-KSHKTLFVLSEHFV-QSEWCKYELDFSHFRLFDENNDVAIL-ILLEPIQSQAIPKRFCKLRK C_familiaris_ENSCAFP00000012269 --SYWVENLLVQKLE-H---FNPPFKLCLHKRDFIPGKWIIDN-------II-DSIE-KSHKTIFVLSENFV-KSEWCKYELDFSHFRLFDENNDAAIL-ILLEPIEKKAIPQRFCKLRK G_gallus_ENSGALP00000015020 --SNWVENIMVQQLE-Q---ACPPFRLCLHKRDFVPGKWIVDN-------II-DSIE-KSHKTLFVLSEHFV-QSEWCKYELDFSHFRLFDENNDVAIL-ILLEPIQSQAIPKRFCKLRK B_taurus_ENSBTAP00000010530 --SYWVENLMVQELE-H---FNPPFKLCLHKRDFIPGKWIIDN-------II-DSIE-KSHKTIFVLSENFV-KSEWCKYELDFSHFRLFDENNDAAIL-ILLEPIDKKAIPQRFCKLRK X_tropicalis_ENSXETP00000048303 --ADWVRGELLYRLE-S---CSPPYRVCIHERDFLPGRWIIDN-------II-ENIE-NSRKIIFVLSSNFI-NSEWCNYELYFAHQRAIGHSLEDIIL-VVKEKVTMEDLPKRFHKLRK B_taurus_ENSBTAP00000028660 --LAAAQE-LVSYLE-G---GAASLRCFLQLRDATPGGAIVSE-------LC-HALS-SSHCRVLLITPGFL-RDPWCRYQMLQALSEAPGAEGRTI---PLMSGLSR-------AAYPA O_cuniculus_ENSOCUP00000002918 --SYWVENLLVQELE-N---SDPPFRLCLHKRDFVPGKWIIDN-------II-DCIE-KSRKTVFVLSQNFV-KSEWCKYELDFSHFRLFDENNDAAIL-VLLEPIEKKAIPQRFCKLRK G_gorilla_ENSGGOP00000013642 --LVAAQD-LVSYLE-G---STASLRCFLQLRDATPGGAIVSE-------LC-QALS-SSHCRVLLITPGFL-QDPWCKYQMLQALTEAPGAEGCTI---PLLSGLSR-------AAYPP M_mulatta_ENSMMUP00000010425 --LVAAQN-LVSYLE-G---SSTSLRCFLQLRDATPGGAIVSE-------LC-QALN-NSHCRVLLITPGFL-QDPWCKYQMLQALTEAPGAEGRTI---PLLSGLSR-------DAYPP A_carolinensis_ENSACAP00000007258 --RKFALEVLPKILE-----DNFGYKLCIFERDISPGAAVIDD-------VQ-SFID-RSRRLIIILSKNYI--SDQVMFELEIGLHKALVERKIKVIL-IEYMPVTN--FDFLPMSL-Q X_tropicalis_ENSXETP00000038393 --ADWVRGELLYRLE-S---CSPPYRVCIHERDFLPGRWIIDN-------II-DNIE-TSRKTIFVLSHNFV-NSEWCNYELYFAHQRAIGHSFEDVIL-VVKENVTLKDLPKRFHKLRK M_domestica_ENSMODP00000002903 --HKFALEILPEALE-----KHFGYKLCIFERDIIPGGAIVDD-------IH-SLIN-KSRRLIIVLSENYM--SSKVKYELESGLHEALVERKIKIIL-IEFTPIRD--FTFLPQSL-K G_gallus_ENSGALP00000026726 AVNEWVMTELVEKLEDQ---KARQFNLCLEERDWLPGQPVFDN-------LS-QSIQ-LSKKTIFVLTNKYI-KSGTFKTTFYMAHQRLLDEKIDVIIL-IFLEKVLQ---KSRYVQLRK P_pygmaeus_ENSPPYP00000004627 --LVAAQD-LVSYLE-D---STASLRCFLQLRDATPGGAIVSE-------LC-QALS-SSHCRVLLITPGFL-QDPWCKYQMLQALTEAPGAEGCTI---PLLSGLSR-------AAYPP G_aculeatus_ENSGACP00000002280 --ADWVRNQLLPCLE-S---NGNSYRLCIHERDFMPGRWIIDN-------II-DNIE-SSRKVIFVLSRHFV-NSEWCNYELYFAQQRAVGKTFSDVIL-VVKEPMDPNSLPSKYLKLKK O_anatinus_ENSOANP00000002290 --FEWVQRAFLMHLD-SQYNDNNRFNLCFEERDFLPGEDHISN-------IR-DAIW-NSRKTICVVTRQFL-KDGWCIEAFNFAQSRYFSDLKDRLIM-VVAGSLSQYQL-MKYQPIRV M_domestica_ENSMODP00000002923 --ESFALDLLPQVLE-----NKYGYTLCLFERDVIPGGAYTED-------IV-KIIK-QSRRVICVLSSSYV--NNPSVFELQAAVNLALEDQTLKLIL-IKFSPFKE--PDSLPQRVRK M_mulatta_ENSMMUP00000029702 --EEFVLLTLRGVLE-----NEFGYKLCIFDRDSLPGGIVTDE-------TL-SFIQ-KSRRLLVVLSPNYVLQGTQALLELKAGLENMASQGNINVIL-VQYKAVKE--TK--VKEL-K P_troglodytes_ENSPTRP00000059752 --LVAAQD-LVSYLE-G---STASLRCFLQLRDATPGGAIVSE-------LC-QALS-SSHCRVLLITPGFL-QDPWCKYQMLQALTEAPGAEGCTI---PLLSGLSR-------AAYPP H_sapiens_ENSP00000279992 --LVAAQD-LVSYLE-G---STASLRCFLQLRDATPGGAIVSE-------LC-QALS-SSHCRVLLITPGFL-QDPWCKYQMLQALTEAPGAEGCTI---PLLSGLSR-------AAYPP C_intestinalis_ENSCINP00000024401 --VEFVYK-MLEEME-----EKRERKMCIHERDFTPGRGIADN-------IV-ECIS-TSRRMVLVVSRKYA-SSAWCQYEVQIALTELHAKRRGRLLVPILLEDVTR--DEQYAGSVTT E_caballus_ENSECAP00000010139 --LVAAQE-LVSYLE-D---SPAGLRCFLQLRDATPGGAIVSE-------LC-QALS-NSHCCVLLITPGFL-QDPWCKYQMLQALTQSPGAEGCTI---PLLSGLTR-------AAYPA R_norvegicus_ENSRNOP00000032224 --LEVAQE-LVSYLE-G---SKASLRCFLQFRDAAPGGAIVSE-------LC-QALS-GSHCRVLLITPGFL-RDPWCKYQMLQALTEAPGSEGCTI---PLLSGLTR-------AAYPP H_sapiens_ENSP00000072516 --EEFVLLTLRGVLE-----NEFGYKLCIFDRDSLPGGIVTDE-------TL-SFIQ-KSRRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVIL-VQYKAVKE--TK--VKEL-K P_troglodytes_ENSPTRP00000027076 --EEFVLLTLRGVLE-----NEFGYKLCIFDRDSLPGGIVTDE-------TL-SFIQ-KSRRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVIL-VQYKAVKE--TK--VKEL-K X_tropicalis_ENSXETP00000032922 --EEFVLVTLRGVLE-----NEFGYKLCIFDRDSLPGGTVTDE-------TL-TFIK-KSRRLLVVISPSYILKGTQALLELKAGLENMATQGNIRIIL-VQYKAIKS--REK-VKEL-K X_tropicalis_ENSXETP00000009956 --EIWVVEKLLHMLEEQ---GQRKFKLCFKPRDFVPGIYHLDN-------IQ-DAIS-NSRKTLCVVSRKYL-ESEWCREEMQLACSWAFSYKEDVLLM-VFLEEIPEYRL-SAYHKLRK P_pygmaeus_ENSPPYP00000016111 --EEFVLLTLRGVLE-----NEFGYKLCIFDRDSLPGGIVTDE-------TL-SFIQ-KSRRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVIL-VQYKAVKE--TK--VKEL-K A_aegypti_AAEL000633-PA --EAFVAEELAPMLE-N---GDPSYKLCLHYRDFPVGAYIADT-------IV-QAVE-SSRRTIMVLSENFI-KSEWCRFEFKSAHHQVLRDRRRRLIV-ILLGEVPQ---KDLDPDIRL G_gallus_ENSGALP00000001610 --LEFVEE-LVSYLE-S---QPQSLRCFLQLRDSVAGSAVMTE-------LC-EAVQ-NSHCWVMLITPSFL-QDPWCRYQMHQALAEAPMANGRTI---PVLKDIDR-------KDYPR O_cuniculus_ENSOCUP00000004210 --EEFVLLTLRGVLE-----NEFGYKLCIFDRDSLPGGIVTDE-------TL-SFIQ-KSRRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVIL-VQYKAVKE--TK--VKEL-K X_tropicalis_ENSXETP00000057557 --SDWVKNMLLPNLE-R---KDGSIKICHHERHFIPGKAIIEN-------II-DCIE-KSFKSIFVLSPNFI-QSDWCHYELYFAQHTLFGKNSNNLIL-ILLDPIPQYSIPNKYNKLRS A_gambiae_AGAP012385-PA --EAFVAEELAPMLE-N---EDPSYKLCLHYRDFPVGAYIADN-------IL-QAVE-SSRRTIMVLSENFI-KSEWCRFEFKSAHHQVLRDRRRRLIV-ILLGEVPQ---KDLDPDIRL A_carolinensis_ENSACAP00000000788 --EEFVLLTLRGVLE-----NEFGYKLCIFDRDSLPGGIVTDE-------TL-GFIQ-RSRRLLVVLSPNYVLQGTQALLELKAGLEDMASRGTIKVIL-VQYRAIKK--SK--VKELRQ X_tropicalis_ENSXETP00000054706 --ADWVRGELLYRLE-S---CSPPYRVCIHERDFLPGRWIIDN-------II-ENIE-SSRKIIFVLSRNFV-NSEWCNYELYFAHQRAIGHAFEDVIL-VVKEKVTMEDLPKRFQKLRK P_troglodytes_ENSPTRP00000021076 --HTFAVEILPRVLE-----KHFGYKLCIFERDVVPGGAVADE-------IH-SLIE-KSRRLIIVLSKSYM--SNEVRYELESGLHEALVERKIKIIL-IEFTPVTD--FTFLPQSL-K M_musculus_ENSMUSP00000091395 --LEAAQE-LVSYLE-G---SQASLRCFLQLRDAAPGGAIVSE-------LC-QALS-RSHCRVLLITPGFL-RDPWCKYQMLQALTEAPASEGCTI---PLLSGLSR-------AAYPP 1930 1940 1950 1960 1970 1980 1990 2000 2010 2020 2030 2040 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_mulatta_ENSMMUP00000001339 ILRFI-TVCDYTNPCT----KSWFWTRLAKALSLP------------------------------------------------------------------------------------- H_sapiens_ENSP00000379625 ILRFI-TVCDYTNPCT----KSWFWTRLAKALSLP------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000003761 ILRFI-TVCDYTNPCT----KSWFWTRLAKALSLP------------------------------------------------------------------------------------- E_caballus_ENSECAP00000001633 ILRFI-TVCDYTNPCT----KSWFWTRLAKALSLP------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000025449 ILRFI-TVCDYTNPCT----KSWFWTRLAKALSLP------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000015673 ILRFI-TVCDYTNPCT----KSWFWTRLAKALSLP------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000007386 ILRFI-TVCDYTNPCT----KSWFWTRLAKALSLP------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000002088 ILRFI-TVCDYTNPCT----KSWFWTRLAKALSLP------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000000735 ILRFI-TVCDYTNPCT----QNWFWTRLAKALSMP------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000018341 ILRFI-TICDYTNPCT----KSWFWTRLAKALSLP------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000035092 ILRFI-TICDYTNPCT----KSWFWTRLAKALSLP------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000009820 ILRFI-TLCDYTNPAT----KKWFWMRLAKSLLLP------------------------------------------------------------------------------------- O_latipes_ENSORLP00000012280 ILRFL-TVCDYTKPCT----QAWFWIRLAKALSLP------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000015721 ILRFL-TLCDYTRPCT----QTWFWKRLATALSLP------------------------------------------------------------------------------------- D_rerio_ENSDARP00000020711 ILRFL-TICDYSKPCT----QVWFWTRLAKALSLP------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000000429 ILRFI-TICDYTNPCT----KKWFWTRLAKSLMLP------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000039929 ILRFI-TLCDYTNPCT----KGWFWERLAKALSR-------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000044800 ILRFL-TLCDYTRPCT----QAWFWKRLAKALSLP------------------------------------------------------------------------------------- G_gallus_ENSGALP00000009551 ILRFI-TICDYTNPCT----KMVLDKTGKISLAAVMQSFESFFSICPGCAFGPRCSYSISLQNVDPRSQRLEPAAGSKEFSVALFHNLEGEIEQLCGCSYLIQRAIASSTW--------- G_aculeatus_ENSGACP00000004643 ILRFL-TICDYTRPCT----QAWFWVRLAKALSQPHKDQASSCV---------------------------------------------------------------------------- O_anatinus_ENSOANP00000001873 ILRFI-TVCDYTNPCT----KAWFWPRLAKALALP------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000020077 LLAGI-NPCNRTRVLE----DSWFWNSVIRSLGGVQDNK--------------------------------------------------------------------------------- A_aegypti_AAEL007768-PA NLKFY-FILDYKRSNK----LYNFWDKLEDAIKVRTDSPVTEIKNQS-----------KAIETVSIPKITVEDANESSADKVDRTQTKPEQLTTGTSHSVSQPIKKSLSSWDVSNALNRV A_gambiae_AGAP005252-PA HLRYT-CRLDYQRSQN----LYNFWDKLAESIRDTPRKVGLEVSGRELPAPQKPPVHSKPVELIGPPQPLPKVVVEQPPLVVKLPRAAEQDSRTGS-------LKKSHSFWDIFSNFGHK D_melanogaster_FBpp0087679 TLGIY-THIKYAGDSK----LFNFWDKLARSLHDLDAFSIYSTRQVQTPSPVEESAPRVTTPSIRIQINDKDVTDMPNYNSCKVPEAETTIVSVSGDTGSPLPEHKPKKKDRFLRRITHS A_gambiae_AGAP010636-PA YLKTN-TYVRW-----D---DPWFWEKLHYAMPHKRRL-KGVQG----TDNMCMES-------------------VDKRNPLKTPTTTTL-------------------PINVVEKDDAN A_gambiae_AGAP000999-PA YLKTN-TYVRW-----D---DPWFWDKLHYAMPHKRRP-KGVQA----TDNMRMAS-------------------VDKLNLLKAPAIMTPAS----SETT--------PPVEHAEKGIAH M_musculus_ENSMUSP00000045770 LLSRN-TYLEWEDNPLG---RHIFWRRLKNALLDGKASNPEQTAEEEQ----ETATWT-------------------------------------------------------------- R_norvegicus_ENSRNOP00000014020 LLSRN-TYLEWEDNALG---RHIFWRRLKKALLDGKALNPDETSEEEQ----EATTLT-------------------------------------------------------------- M_domestica_ENSMODP00000024473 LLNRN-TYLEWEDTNLG---RHVFWRRLRKALLDGRTKNPKGAAEEEFSQP-VSPT---------------------------------------------------------------- A_gambiae_AGAP001002-PA YLKTN-TYVRW------------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000009600 LKESV-SFVTWKGEKSK-RSGSQFWKALRLALPLRSLSAS-AGWNESCSSQSDISLDPIQRRRSRLKGQPDPRGATPVTLTPGRTASASASKAKQRAKHFLTCRCCGTPCDGSSGHKQRA A_aegypti_AAEL000057-PA YLKTN-TYIKW-----G---DPWFWQKLRYAMPHPARV-KGVRWYR---------E-------------------RNRVDIAPTVEVN-------------------------------- D_melanogaster_FBpp0084432 YLKMN-TYLKW-----G---DPWFWDKLRFALPHRRPV-GNIGNGALIKTALKGST-------------------DDKLELIKPSPVTPPLT----TPPAEATKNPLVAQLNGVTPHQAI P_pygmaeus_ENSPPYP00000021907 LLSRN-TYLEWEDSVLG---RHL-WRRLRKALLDGKSWNPEGTVGTG-NWQ--EATSI-------------------------------------------------------------- A_gambiae_AGAP010634-PA YLKTN-TYIRW-----D---DPWF------------------------------------------------------------------------------------------------ A_gambiae_AGAP010669-PA YLKTN-TYVRW-----D---DPWFWDKLHYAMPRKRRP-KDVQT----TDNMRMAS-------------------GDK---LNLPIIMTP-------------------PIK-------- B_taurus_ENSBTAP00000008190 LLSRN-TYLEWEDSVLG---RHVFWRRLRKALLAGKPQSPEGTADAETNPQ-EATTST-------------------------------------------------------------- O_cuniculus_ENSOCUP00000001909 LLSRN-TYLEWEDTVLG---RHIFWRRLRKALLDGKTLSPEGMARAENNQQ-EAMTLI-------------------------------------------------------------- M_domestica_ENSMODP00000018871 LKDSV-SFVSWEGERSK-RSGSKFWKALRLALPLRSLSAG-SGWNESCSSQSDISLDHIQRRRGRLKVPQEFLSSRRAA---GAGPPTPGAVAKHQGKPSVACRCCVTYCKGEKPLRNKN T_guttata_ENSTGUP00000003444 YLRRN-TYLEWKNKEIS---KHIFWRQLIGVLLEGKNWNH-------------------------------------------------------------------------------- D_rerio_ENSDARP00000055005 IMNSR-TYLEWPEDEDK---RDEFWSNLRAALQRDEC----------------------------------------------------------------------------------- O_anatinus_ENSOANP00000020856 YLHRN-TYLEWEDNKIS---RHIFWRRLRNALLDGSV--PSGIREKVGGIN-ESITGI-------------------------------------------------------------- T_guttata_ENSTGUP00000005321 IMNTK-TYLEWPAGEEQ---QQVFWENLKGALKS-------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000036398 LLSRN-TYLEWEDSVLG---RHIFWRRLRKALLDGKSWNPEGTVGTGCNWQ--EATSI-------------------------------------------------------------- D_melanogaster_FBpp0075360 YLKTN-TYLQW-----G---DKLFWQKLRFALPDVSSS-QRSNVAGQSCHVPINHASYHHHHHV------------------HQQAM-PLPH----SVHHHQQ--QFMLPPP-------P G_gorilla_ENSGGOP00000007772 LLSRN-TYLEWEDSVLG---RHIFWRRLRKALLDGKSWNPEGTVGTGCNWQ--EATSI-------------------------------------------------------------- H_sapiens_ENSP00000363089 LLSRN-TYLEWEDSVLG---RHIFWRRLRKALLDGKSWNPEGTVGTGCNWQ--EATSI-------------------------------------------------------------- C_familiaris_ENSCAFP00000031395 LLSRN-TYLEWEDSVLG---RHIFWRRLRKALLDGKPWSPEGTEDAPQNLQVDASTKS-------------------------------------------------------------- E_caballus_ENSECAP00000008292 LLNRN-TYLEWEDSVLG---RHIFWRRLRKALLDGKPWSPAGTADAAESRQHDAETST-------------------------------------------------------------- A_aegypti_AAEL007619-PA YLKTN-TYVKW-----G---DPWFWQKLRYAMPHPLKV-KGIKS-----------A-------------------VSEIHLQQVTTKATPTA----V----------------------- C_familiaris_ENSCAFP00000020672 LKESV-SFVSWKGEKSK-HSGSKFWKALRLALPLRSLSAS-SGWNESCSSQSDISLDHVQRRRSRLKEPPELQGTERVA---GTS-AAPDTMSKHRGKPSAACRCCVTYCEGESHLRSKS M_mulatta_ENSMMUP00000039787 LLSRN-TYLEWEDSVLG---QHIFWRRLRKALLDGRSWNPE-TVGTGCN----------------------------------------------------------------------- E_caballus_ENSECAP00000004036 LKESV-SFVSWKGEKSK-HSGSKFWKALRLALPLRSLSAS-SGWNESCSSQSDISLDHAQRRRSRLKDPPELQSSGRAA---GAS-PAPGTMSKHRGKSSAACRCCVTYCEGESHLRSKS D_melanogaster_FBpp0080080 YLKLN-TYLKW-----G---DPLFWSKLYYAMPHNRRVLKGQKK---------------------------------------------------------------------------- C_familiaris_ENSCAFP00000015327 ELRFM-YFVDGRGPDGG-------FHQVKEAVMRCKLLEGERKSGSATAADLL------------------------------------------------------------------- T_guttata_ENSTGUP00000005325 IMNTK-TYLEWPLEEEQ---QQMFWFNLKIALRS-------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000010774 ELRFM-YYVDGRGPDGG-------FRQVREAVLHYLRTLG-------------------------------------------------------------------------------- O_anatinus_ENSOANP00000029040 IMNTK-TYLKWPSDETE---RETFWLNLKSAIKTEHFIEDSRIAKESA------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000051260 LKESV-SFVSWKGEKSK-HSGSKFWKALRLALPLRSLSAS-SGWNESCSSQSDISLDHVQ-RRSRLKEPPELQSSERVS---GAA-PAPGTISKHRGKPSAACRCCVTYCEGESHLRSKS E_caballus_ENSECAP00000015544 IMNTK-TYLEWPTDEAQ---QEGFWLNLRAAIKS-------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000015503 LMNTK-TYLEWPSDEDQ---KSIFWFNLKTAIKS-------------------------------------------------------------------------------------- H_sapiens_ENSP00000260010 IMNTK-TYLEWPMDEAQ---REGFWVNLRAAIKS-------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000003012 IMNTK-TYLEWPMDEAQ---REGFWVNLRAAIKS-------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000016910 IMNTK-TYLEWPMDEAQ---REGFWVNLRAAIKS-------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000028379 IMNTK-TYLEWPMDEAQ---REGFWVNLRAAIKS-------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000093843 LKESV-SFVSWKGEKSK-HSGSKFWKALRLALPLRSLSAS-SGWNESCSSQSDISLDHVQ-RRSRLKEPPELRSSERVS---GAE-PAPGTMSKHRGKPSAACRCCVTYCEGESHLRSKS M_mulatta_ENSMMUP00000020834 IMNTK-TYLEWPMDEAR---QEGFWVNLRAAIKS-------------------------------------------------------------------------------------- A_gambiae_AGAP001004-PA YLHTN-TYVRW-----G---DPWFWDKLRFAMPHPPKV-RGASG----TASTVVKSGVSTAGGLFMKQLQGAAPVDDRLELIKPQVTPATPP----ALTT--------PPTEPISSATPA M_musculus_ENSMUSP00000029623 IMNTK-TYLEWPLDEGQ---QEVFWVNLRTAIKS-------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000013025 IMNTK-TYLEWPLDEGQ---REVFWANLRTAIKS-------------------------------------------------------------------------------------- A_aegypti_AAEL007613-PA YLKMN-TYVKW-----G---DQWFWDKLRYAMPHPPTV-KGLKGKGLIKNHLKSSV-------------------DDKLELIKPVPVTPPPL----TTPP--------AEMNGHARSPPF D_melanogaster_FBpp0079369 YMVLN-TYLDR-----N---NPNFWNKLMYSMPHASHL-KRSRS---------------------------------------------------------------------------- D_rerio_ENSDARP00000015475 MLNTK-TYLEWPQQPTE---QNFFWIQLRSVLGKPNSIRPRTISRHSRLSSARSVSLIEAPQIQDPEGPDEEDHQNSPQPSNKCQLTCIEVA---------------------------- O_anatinus_ENSOANP00000007049 LKESV-PFISWKGEKSN-KPGSQFWKALRLALPLRSLNAG-SGWNDSCSSQSDLSLDHIQRRRSRLKAPSERQDSKSGL---STV-PTPMARAKHRAKPSSACRCCVTYCGGQSQLRSKS A_aegypti_AAEL003507-PA YLRTN-TYIRW-----G---DPWFWDRLQYAMPHAPRI-RGVKELRCARSYELGML-------------------EDQMEMSKSQIIAYDAF-------------------RGYL-NPTL G_gallus_ENSGALP00000015018 IMNTK-TYLEWPPDEEQ---QQMFWENLKAALKS-------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000012269 IMNTK-TYLEWPTDDAQ---QEGFWLNLRTAIKS-------------------------------------------------------------------------------------- G_gallus_ENSGALP00000015020 IMNTK-TYLEWPPDEEQ---QQMFWENLKAALKS-------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000010530 IMNTK-TYLEWPVDETQ---QEGFWLNLRAAIRS-------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000048303 MLRTK-TYLEWPSEPSK---QHFFWIQLKSIL---------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000028660 ELRYM-YFVDGRGPEGG-------FRQVKEAVMRYLQTLG-------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000002918 IMNTR-TYLEWPTEEAE---HAGFWGNLRAAIKS-------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000013642 ELRFM-YYVDGRGPDGG-------FRQVKEAVMRSNQVLKHLLYPGTPEVGVKLETENPCRASDSHRCDKRYRE---------------------------------------------- M_mulatta_ENSMMUP00000010425 ELRFM-YYVDGRGPDGG-------FRQVKEAVMRYLQTLS-------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000007258 LLSSK-QVVKWNKEKSL-PLNSRFWKKLRYAMPAK------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000038393 MLRKK-TYLEWPSEPSK---QHFFWIQLK------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000002903 LLKSH-RILKWKADKSL-PYNSRFWKNLRYLMPAKNTKNVFSSDPLGNELLPVVSKF--------------------------------------------------------------- G_gallus_ENSGALP00000026726 RLCRS-SVLEWPTNPRS---QPYFWQRLKNAIAMNNTLSYNKLLQETV------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000004627 ELRFM-YYVDGRGPDGG-------FRQVKEAVMRYLQTLS-------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000002280 MLRTK-TYLEWPQQVNQ---QAFFWTQLKGVLGKPTATQKRTHSVKS------------------------------------------------------------------------- O_anatinus_ENSOANP00000002290 FIQRQ-HYLKWPENLQD---IGWFLDKLSQSVLKEKDVKKKAN----------------------------------------------------------------------------- M_domestica_ENSMODP00000002923 ALSVL-PTITWKNSKSA-PPNSRFWSRIRYHMPVKNCRKLGSQGFHFFPRIF-------------------------------------------------------------------- M_mulatta_ENSMMUP00000029702 RAKTVLTVIKWKGEKSK-YPQGRFWKQLQVAMPVKKSPRR-SSSDEQGLSYSSLK----------------------------------------------------------------- P_troglodytes_ENSPTRP00000059752 ELRFM-YYVDGRGPDGG-------FRQVKEAVMRSNQLLKHLLYHGTPEIGVKLETENPCRASDSHKCDKRYRE---------------------------------------------- H_sapiens_ENSP00000279992 ELRFM-YYVDGRGPDGG-------FRQVKEAVMRSNQVLKHLLYHGTPEIGVKLETENPCRASDSHKCDKRYRE---------------------------------------------- C_intestinalis_ENSCINP00000024401 ILSAI-TAIQAPKAQDNDRTWTNFWNKLDKTLT--------------------------------------------------------------------------------------- E_caballus_ENSECAP00000010139 ELRFM-YFVDGQGPDHG-------FRQVKQAVMRYLQTLS-------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000032224 ELRFM-YYVDGRGQDGG-------FYQVKEAVIHLLDSMT-------------------------------------------------------------------------------- H_sapiens_ENSP00000072516 RAKTVLTVIKWKGEKSK-YPQGRFWKQLQVAMPVKKSPRR-SSSDEQGLSYSSLK----------------------------------------------------------------- P_troglodytes_ENSPTRP00000027076 RAKTVLTVIKWKGEKSK-YPQGRFWKQLQVAMPVKKSPRR-SSSDEQGLSYSSLK----------------------------------------------------------------- X_tropicalis_ENSXETP00000032922 LAESVLGVIKWKGDKSK-FPNGRFWKQLHVAMPVKKQ----------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000009956 LIKQN-TYIDWPEDPRG---EEVFWLKLRQALDGG------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000016111 RAKTVLTVIKWKGEKSK-YPQGRFWKQLQVAMPVKKSPRR-SSSDEQGLSYSSLK----------------------------------------------------------------- A_aegypti_AAEL000633-PA YLKTN-TYLQW-----G---DKLFWEKLRFALPDVPNN-QRRR---QQQSINMTHSNFRNNYQLTR-TPNNRNNTSNQLIMLQQQPPQPDPRLRQQQQQEHSSLQQQPLPLPGLAQQPQP G_gallus_ENSGALP00000001610 ELRNL-YYIYVALKENS-------FRQIRDTVLRYLEELCRSSTSGMQ------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000004210 RAKTVLTVIKWKGEKSK-YPQGRFWKQLQVAMPVKKSPRR-CSSDEQGLSYSSLK----------------------------------------------------------------- X_tropicalis_ENSXETP00000057557 IMKHR-TYLEWPKEKGK---HALFWANLREAIHVNLSIKEEDMADPEITIT--------------------------------------------------------------------- A_gambiae_AGAP012385-PA YLKTN-TYLQW-----G---DKLFWEKLRFALPDVPNN-QRRQ---HQPNISLTHSNVRNSYQLTRVAPSNRTN--NQLTAQHQDPRGPQGR----STDYHAT--QQPLPLPGLASEMQP A_carolinensis_ENSACAP00000000788 AKAAL-SVIKWKGEKSS-YPRGRFWKQLLVEMPIKNRPKSTAAADRRTSSFSSLKEV--------------------------------------------------------------- X_tropicalis_ENSXETP00000054706 MMRTK-TYLEWPSEQNR---QHFFWIQLKSILGSPTGTSSSSSLCSWNQVSDSYP----------------------------------------------------------------- P_troglodytes_ENSPTRP00000021076 LLKSH-RVLKWKADKSL-SYNSRFWKNLLYLMPAKTVKPGRDESEVLPVLSES------------------------------------------------------------------- M_musculus_ENSMUSP00000091395 ELRFM-YYVDGRGKDGG-------FYQVKEAVIHYLETLS-------------------------------------------------------------------------------- 2050 2060 2070 2080 2090 2100 2110 2120 =========+=========+=========+=========+=========+=========+=========+=========+===== M_mulatta_ENSMMUP00000001339 ------------------------------------------------------------------------------------- H_sapiens_ENSP00000379625 ------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000003761 ------------------------------------------------------------------------------------- E_caballus_ENSECAP00000001633 ------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000025449 ------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000015673 ------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000007386 ------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000002088 ------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000000735 ------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000018341 ------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000035092 ------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000009820 ------------------------------------------------------------------------------------- O_latipes_ENSORLP00000012280 ------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000015721 ------------------------------------------------------------------------------------- D_rerio_ENSDARP00000020711 ------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000000429 ------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000039929 ------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000044800 ------------------------------------------------------------------------------------- G_gallus_ENSGALP00000009551 ------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000004643 ------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000001873 ------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000020077 ------------------------------------------------------------------------------------- A_aegypti_AAEL007768-PA L-----TSKSKNASSSTSELPTGAENSDQELKKVKWYSKLGLSSSKSSLDGTGEKSEKKKTKWYKTSKKIATAM----------- A_gambiae_AGAP005252-PA KDKLNGSTSQLNLNEMATPLPSPKKVGSSPLALIRRDKKQPSAASASSAPSACPLDLPPVIKPVKSKKKWYKPGSRKLASAV--- D_melanogaster_FBpp0087679 FGKTARSDGASGKTLRHAHSVSTINVTERERTLSASSSNISTTSESKKSFIKWQPNILKKALFSRSSSKLQTPG----------- A_gambiae_AGAP010636-PA SVGTG---------------------------------------------I-----------------------SVISSERE--- A_gambiae_AGAP000999-PA DGPLGCYGD--------------------------------PSKPSTMPPF-----------------------IISNGMSN--- M_musculus_ENSMUSP00000045770 ------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000014020 ------------------------------------------------------------------------------------- M_domestica_ENSMODP00000024473 ------------------------------------------------------------------------------------- A_gambiae_AGAP001002-PA ------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000009600 VAE----PRWDGHLCTPGSGRAPAPALQGRGRAEPPPAQGPALALCHYSDLSNNNDFYVL------------------------- A_aegypti_AAEL000057-PA ------------------------------------------------------------------------------------- D_melanogaster_FBpp0084432 MIANGKNGLTNLYTPNG----------KSHGNGHINGAFIINTN--------------------------------AKQSDV--- P_pygmaeus_ENSPPYP00000021907 ------------------------------------------------------------------------------------- A_gambiae_AGAP010634-PA ------------------------------------------------------------------------------------- A_gambiae_AGAP010669-PA ------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000008190 ------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000001909 ------------------------------------------------------------------------------------- M_domestica_ENSMODP00000018871 RAEAPIQPQWETHLCKPVPQQVATHWVQNGSRLSTPAPQISALALHHFTDLSNNNDFYVL------------------------- T_guttata_ENSTGUP00000003444 ------------------------------------------------------------------------------------- D_rerio_ENSDARP00000055005 ------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000020856 ------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000005321 ------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000036398 ------------------------------------------------------------------------------------- D_melanogaster_FBpp0075360 QQPGSFRRQPSLHQQQQQQQQIRGNNNTTQQQQQQQAALLMGGGSVGGPAPQMIPLAGGIQQQSLPLPPNQQPTPASRNLHM--- G_gorilla_ENSGGOP00000007772 ------------------------------------------------------------------------------------- H_sapiens_ENSP00000363089 ------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000031395 ------------------------------------------------------------------------------------- E_caballus_ENSECAP00000008292 ------------------------------------------------------------------------------------- A_aegypti_AAEL007619-PA ------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000020672 RAEIHTQPQWETHLCKPVPQESETQWIQNGTRLEPPASQISALALHHFTDLSNNNDFYIL------------------------- M_mulatta_ENSMMUP00000039787 ------------------------------------------------------------------------------------- E_caballus_ENSECAP00000004036 RAEIHTQPQWETHLCKPVSQESETQWIQNGTRLEPPAPQISALALHHFTDLSNNNDFYIL------------------------- D_melanogaster_FBpp0080080 ----------------------------------------------------------------------------HAGPLI--- C_familiaris_ENSCAFP00000015327 ------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000005325 ------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000010774 ------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000029040 ------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000051260 RAEMHTHPQWETHLCKPDLQESESQWIQNGTRPE-PAPQISALALRHFTDLSNNNDFYIL------------------------- E_caballus_ENSECAP00000015544 ------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000015503 ------------------------------------------------------------------------------------- H_sapiens_ENSP00000260010 ------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000003012 ------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000016910 ------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000028379 ------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000093843 RAEMHTHPQWETHLCKPPLQESESQWIQNGTRPE-PAPQISALALRHFTDLSNNNDFYIL------------------------- M_mulatta_ENSMMUP00000020834 ------------------------------------------------------------------------------------- A_gambiae_AGAP001004-PA PGPFVISGNGGGVGGAGAQLLHQQLSNAYRASGHINGAFVINSN--------------------------------AKQSDV--- M_musculus_ENSMUSP00000029623 ------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000013025 ------------------------------------------------------------------------------------- A_aegypti_AAEL007613-PA TISNGKVVNGNGYHINGHVM-------NGHVNGHINGAFVINSN--------------------------------AKQSDV--- D_melanogaster_FBpp0079369 ----------------------------------------------------------------------------DAETKV--- D_rerio_ENSDARP00000015475 ------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000007049 RAEVQVQPQWETHLCKPVPRHSETHWIQNGNKAEVPAPQISSLALHHFTDLSNNNDFYVL------------------------- A_aegypti_AAEL003507-PA SRSIGRSLE----EFDG--------------DGNFEGVDTLDSRCFDELII-----------------------IITKESEV--- G_gallus_ENSGALP00000015018 ------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000012269 ------------------------------------------------------------------------------------- G_gallus_ENSGALP00000015020 ------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000010530 ------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000048303 ------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000028660 ------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000002918 ------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000013642 ------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000010425 ------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000007258 ------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000038393 ------------------------------------------------------------------------------------- M_domestica_ENSMODP00000002903 ------------------------------------------------------------------------------------- G_gallus_ENSGALP00000026726 ------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000004627 ------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000002280 ------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000002290 ------------------------------------------------------------------------------------- M_domestica_ENSMODP00000002923 ------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000029702 ----------------------------------------------------------NV------------------------- P_troglodytes_ENSPTRP00000059752 ------------------------------------------------------------------------------------- H_sapiens_ENSP00000279992 ------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000024401 ------------------------------------------------------------------------------------- E_caballus_ENSECAP00000010139 ------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000032224 ------------------------------------------------------------------------------------- H_sapiens_ENSP00000072516 ----------------------------------------------------------NV------------------------- P_troglodytes_ENSPTRP00000027076 ----------------------------------------------------------NV------------------------- X_tropicalis_ENSXETP00000032922 ------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000009956 ------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000016111 ----------------------------------------------------------NV------------------------- A_aegypti_AAEL000633-PA PQLLQHQRQQQQQQQEQQQR-----------------------------------------------GAGNAS-PRTVGIHI--- G_gallus_ENSGALP00000001610 ------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000004210 ----------------------------------------------------------NV------------------------- X_tropicalis_ENSXETP00000057557 ------------------------------------------------------------------------------------- A_gambiae_AGAP012385-PA QQLHSSQQQQQQQQQQQQQQQQQQQQQQQQQQQHQPPS---------------------TQAQLRPSAPLNTP-PNSWHSHLKAH A_carolinensis_ENSACAP00000000788 ------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000054706 ------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000021076 ------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000091395 -------------------------------------------------------------------------------------