>M_musculus_ENSMUSP00000027012 ------------------------------------------------------------ ---------MAENKHPDKPLKVLEQLGKEVLTE--Y---------LEKLVQSNVLKLKE- -------------------------------------------------E---------- -------DKQK------FNNAERSDKRWVFVDAMKKKHSKVGEMLLQTFF--SVDPGSHH GEANLEM----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --EEPEES------LNT----------LKLCSPEEFTRL----CREKTQEIYPI-KEAN- GRTRKALIICNTEFK----------HLSLRYGANFDIIGMKGLLEDLGYDVV-VKEELTA EGMESEMKDFAALSE--HQTSDSTFLVLMSHGT-L-------HGICGTMHSE-------- KTPDVLQYDTIYQIFNNCHCPGLRDKPKVIIVQACRG-------------GNSGEMW-IR ---ESSKPQLCRGVDLP---------------R-NMEADAVKLSHVEKDFIA---FYSTT PH--HLSYRDKTGGSYFITRLISCFRK-------HA-CSCHLF--DIFLKVQQSFEKASI H-----------SQMPTIDRA----TLTRYFYLFPGN---------------- >R_norvegicus_ENSRNOP00000058685 ------------------------------------------------------------ ---------LTENNHPDKPLKVLEELGKEFLTE--Y---------LEKLVQSNVLKLKE- -------------------------------------------------E---------- -------EKQK------FNNAERSDKRWVFVDVLKRKHNQVGKMLLQTFL--NVDSGSHH GEANLEM----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --EEPEES------VDT----------LKLCSSEEFTRL----CREKKQEIYPI-KETN- GRTRKALIICNTEFK----------HLSLRYGANIDISGMKGLLEELGYDVV-VKEELTA EGMESEMKDFAALSE--HQTSDSTFLVLMSHGT-L-------QGLCGTMHSE-------- ATPDVLLYDTIYQIFNNCHCPGLRDKPKVIIVQACRG-------------GNPGEVW-IR ---ESSGAHSYRAVDLP---------------R-NMEADAVRMSHVEKDFIA---LYSTT PH--HYSYTDWPRGSYXSSKCIFCLRM-------XT-XTVYLY--ELHNNVQQSFEKASI N-----------SQMPTIDRA----TLTRYFYLFPGN---------------- >P_pygmaeus_ENSPPYP00000004373 ------------------------------------------------------------ ---------MAEGNHRKKPLKMLESLGKDFLTG--V---------LDNLVEQNVLNWKE- -------------------------------------------------E---------- -------EKKK------YYDAKTEDKVRVMADSIQEKQRMAGQMLLQTFF--NIDQISPN KKAHPNM-----EAGP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --PESGES------TDA----------LKLCPHEEFLRL----CKERAEEIYPI-KERN- NRTRLALIICNTEFD----------HLPPRNGADFDITGMKELLEGLDYSVD-VEENLTA RDMESALRAFAARPE--HKSSDSTFLVLMSHGI-L-------EGICGTVHDE-------- KKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRG-------------ANRGELW-VR ---DSPASLEVASSQSP---------------E-NLEEDAVYKTHVEKDFIA---FCSST PH--NVSWRDSTMGSIFITQLITCFQK-------YS-WCCHLE--EVFRKVQQSFETPRA K-----------AQMPTIERL----SMTRYFYLFPGN---------------- >H_sapiens_ENSP00000347741 ------------------------------------------------------------ ---------MAEGNHRKKPLKVLESLGKDFLTG--V---------LDNLVEQNVLNWKE- -------------------------------------------------E---------- -------EKKK------YYDAKTEDKVRVMADSMQEKQRMAGQMLLQTFF--NIDQISPN KKAHPNM-----EAGP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --PESGES------TDA----------LKLCPHEEFLRL----CKERAEEIYPI-KERN- NRTRLALIICNTEFD----------HLPPRNGADFDITGMKELLEGLDYSVD-VEENLTA RDMESALRAFATRPE--HKSSDSTFLVLMSHGI-L-------EGICGTVHDE-------- KKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRG-------------ANRGELW-VR ---DSPASLEVASSQSS---------------E-NLEEDAVYKTHVEKDFIA---FCSST PH--NVSWRDSTMGSIFITQLITCFQK-------YS-WCCHLE--EVFRKVQQSFETPRA K-----------AQMPTIERL----SMTRYFYLFPGN---------------- >P_troglodytes_ENSPTRP00000041705 ------------------------------------------------------------ ---------MAEGNHRKKPLKMLESLGKDFLTG--V---------LDNLVEQNVLNWKE- -------------------------------------------------E---------- -------EKKK------YYDAKTEDKVRVMADSIQEKQRMAGQMLLQTFF--NIDQISPN KKAHPNM-----EAGP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --PESGES------TDA----------LKLCPHEEFLRL----CKERAEEIYPI-KERN- NRTRLALIICNTEFD----------HLPPRNGADFDITGMKELLEGLDYSVD-VEENLTA RDMESALRAFATRPE--HKSSDSTFLVLMSHGI-L-------EGICGTVHDE-------- KKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRG-------------ANHGELW-VR ---DSPASLEVASSQSS---------------E-NLEEDAVYKTHVEKDFIA---FCSST PH--NVSWRDSTMGSIFITQLITCFQK-------YS-WCCHLE--EVFRKVQQSFETPRA K-----------AQMPTIERL----SMTRYFYLFPGN---------------- >E_caballus_ENSECAP00000010831 ------------------------------------------------------------ ---------MAEDRQERNLLKTLESVGKELITG--L---------SVGLVEKDVLKLKE- -------------------------------------------------E---------- -------ERKK------FYEAKPGDKPWVLVDSVRDRRHEAGQILWQALF--NIDRSVIS RKALEEI-----AAGP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --AESAEP------TDT----------LKLCPHEEYLRL----CKERAEEIYPI-KDKK- DRTRRALIICNTEFD----------HLPFRTGADFDLSGMKRLLEDLGYSVD-VKEQLTA TDMESVLREFAAHQD--HRSSDSTFLVFMSHGI-L-------DGICGTTHSD-------- EKPDVLPYDTIFRLFNNRNCPSLKDKPKVIIVQACRG-------------ANRGELW-IR ---DCLAALA------P---------------E-NLEEDAVYKTHVEKDFIA---FCSST PH--NVSWRDITKGSLFITQLITCFQR-------HS-WCCHVE--EVFRKVQQSFEKPSI K-----------TQMPTTERQ----SMTRYFYLFPGN---------------- >C_familiaris_ENSCAFP00000031565 ------------------------------MYSSRQQHGLSLEHILKNGEIARDGKTYVV PIVEGVFVFLTEDKHDKNPFKILETVGKELITG--V---------LHGLLEKDILKLED- -------------------------------------------------A---------- -------EKKT------FYDAKPEDKPWVILNSVRQKRQEAGQALVHTFI--NTDKYSTS VEAFVEN-----MPGPTI------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --PDSEES------TDT----------LKLCPPETFVKM----YKEKAEEIYPI-KERK- DRTRLALIICNIEFD----------HLSTRDGAELDIAGMESLLEGLGYSVV-VKRKLTA KGMESVLREFAARPE--HKSSDSTFLVLMSHGI-L-------NGICGTAHSV-------- ENPDVLAYDTIFQIFNNRHCLNLKDKPKVIIIQACRG-------------ENPGELW-VS ---DSPKASTDSWTHQP---------------L-MLKSDAIHKVHVEKDFIA---FCSST PH--NVSWRHITKGSLFIAQLITCFQK-------YS-WCCHLE--GVFRKVQQSFEKPDV K-----------AQMPTIERV----SMTRYFYLFPGN---------------- >B_taurus_ENSBTAP00000027820 ------------------------------------------------------------ ---------MAEDKHNKNPLKMLESLGKELISG--L---------LDDFVEKNVLKLEE- -------------------------------------------------E---------- -------EKKK------IYDAKLQDKARVLVDSIRQKNQEAGQVFVQTFL--NIDKNSTS IKAPEET-----VAGP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --DESVGS------AAT----------LKLCPHEEFLKL----CKERAGEIYPI-KERK- DRTRLALIICNTEFD----------HMPPRNGAALDILGMKQLLEGLGYTVE-VEEKLTA RDMESVLWKFAAREE--HKSSDSTFLVFMSHGI-L-------DGICGTMHSE-------- EEPDVLPYDTIFRTFNNRNCLSLKDKPKVIIVQACRG-------------ANRGELW-VS ---DSPPALADSFSQSS---------------E-NLEEDAVYKTHVEKDFIA---FCSST PH--NVSWRDIKKGSLFITRLITCFQK-------YA-WCCHLE--EVFRKVQQSFEKPNV K-----------AQMPTVERL----SMTRYFYLFPGN---------------- >P_pygmaeus_ENSPPYP00000004374 AVPIVEGVFIFLIEDSCKKKRRKNFEAVFKCILQSGLDNLVINHMLKNNVAGQTSIQTL- PNTDQKSTSVKKDNHKKKTIKMLEYLGKDVLHG--V---------FNHLAKHDVVTLKE- -------------------------------------------------E---------- -------EKKK------YYNAKIEDKALILVDSVR-KNRVAHQIFIQTLL--DMDQKITS VKPLLQI-----EAGP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --PESAES------TNT----------LKLCPREEFLRL----CKKNHDEIYPI-KKRE- DRTRLALIICNTEFD----------HLPARDGAQFDILGMKELLQGLDYTVV-EENNLTA SDMESVLRAFAARPE--HKSSDSTFLVLMSHGI-L-------EGICGTVHDE-------- KKPDVLLYDTIFQIFNSHNCVSLKDKPKVIIVQACRG-------------EKHGELW-VR ---DSPASLAVISSQSS---------------E-NLEADSVRKIHKEKDFIA---FCSST PH--NVSWRDRTRGSIFIMELITCFQK-------YS-CCCHLM--EIFRKVQKSFEVPQA K-----------AQMPTIERA----TLTRDFYLFPGN---------------- >M_mulatta_ENSMMUP00000012893 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------MADSIQEKQRMAGQMLLQTFF--NIDQISPS KKAHLNM-----EARP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --PESGES------ADA----------LKLCPHEEFLRL----CKERAEEIYPI-KERN- DRTRLALIICNTEFD----------HLPPRNGADFDITGMKELLEGLDYSVD-VEENLTA KDMESALRAFAARPE--HKSSDSTFLVLMSHGI-L-------EGICGTAHDE-------- KNPDVLLYDTVFQIFNNRNCLSLKDKPKVIIVQACRG-------------ANRGELW-VR ---DSPASLEVASSQSP---------------E-NLEEDAVYKTHVEKDFIA---FCSST PH--NVSWRDSTMGSVFITQLITCFQK-------YS-WCCHLE--EVFRKVQQSFETPRA K-----------AQMPTIERL----SMTRYFYLFPGN---------------- >P_troglodytes_ENSPTRP00000007279 AVPRVEGVFIFLIEDSGKKKRRKNFEAMFKGILQSGLDNLVINHMLKNNVAGQTSIQTLV PNTDQKSTSVKKDNHKKKTVKMLEYLGKDVLHG--V---------FNYLAKHDVLTLKE- -------------------------------------------------E---------- -------EKKK------YYDAKIEDKALILVDSLR-KNRVAHQMFTQTLL--NMDQKITS VKPLLQI-----EAGP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --PESAES------TNI----------LKLCPREEFLRL----CKKNHDEIYPI-KKRE- DRRRLALIICNTKFD----------HLPARNGAHFDILGMKRLLQGLGYTVI-DEKNLTA RDMESALRAFAARPE--HKSSDSTFLVLMSHGI-L-------EGICGTAHKK-------- KKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRG-------------EKLGELW-VR ---DSPASLAVISSQSS---------------E-NLEADSVCKIHEEKDFIA---FCSST PH--NVSWRDCTRGSIFITELITCFQK-------YS-CCCHLM--EIFRKVQKSFEVPQA K-----------AQMPTIERA----TLTRDFYLFPGN---------------- >H_sapiens_ENSP00000376849 AVPRVEGVFIFLIEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQTLV PNTDQKSTSVKKDNHKKKTVKMLEYLGKDVLHG--V---------FNYLAKHDVLTLKE- -------------------------------------------------E---------- -------EKKK------YYDTKIEDKALILVDSLR-KNRVAHQMFTQTLL--NMDQKITS VKPLLQI-----EAGP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --PESAES------TNI----------LKLCPREEFLRL----CKKNHDEIYPI-KKRE- DRRRLALIICNTKFD----------HLPARNGAHYDIVGMKRLLQGLGYTVV-DEKNLTA RDMESVLRAFAARPE--HKSSDSTFLVLMSHGI-L-------EGICGTAHKK-------- KKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRG-------------EKHGELW-VR ---DSPASLALISSQSS---------------E-NLEADSVCKIHEEKDFIA---FCSST PH--NVSWRDRTRGSIFITELITCFQK-------YS-CCCHLM--EIFRKVQKSFEVPQA K-----------AQMPTIERA----TLTRDFYLFPGN---------------- >G_gorilla_ENSGGOP00000015374 ------------------------------------------------------------ ------------DNHKKKTVKMLEYLGKDVLHG--V---------FNYLAKHDVLTLKE- -------------------------------------------------E---------- -------EKKK------YYDAKIEDKALILVDSXR-KKRVAHQMFTQTLL--NMDQKITS VKPLLQI-----EAGP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --PESAES------TNI----------LKLCPREEFLRL----CKKNHDEIYPI-KKRE- DRRRLALIICNTKFD----------HLPARNGAHFDIXGMKRLLQGLGYTVV-DEKNLTA RDMESXLRAFAXRPE--HKSSDSTFLVLMSHGI-L-------EGICGTKHKK-------- KKPDVLLYDTIFXIFNSRNCXSLKDKPKVIIVQACRG-------------EKHGELW-VR ---DSPASLAVISSQSS---------------E-NLEXDXVCKIHEEKDFIA---FXSST PH--XVSWRDRTRGSIFITELITCFQK-------YS-CCCHLM--EIFRKVQKSFEVPQA K-----------AQMPTIERA----TLTRDFYLFP------------------ >M_mulatta_ENSMMUP00000012894 ------------------------------------------------------------ -----------------------------MLHG--V---------FNHLAKHDVLTLNE- -------------------------------------------------E---------- -------EKEN------YYNVKIEDKALILVDSVR-KNRVAHQRFTQTLL--NMDQRITS VKSLLQI-----EAGP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --PESAES------TNT----------LILCPHEEFLRR----CKENHDEIYPI-KKRE- DRKRLALIICNTKFD----------HLPPRTGADFDILGMKGLLQGLGYNVV-DKTKLTA REMESELRAFARRPE--HKSSDSTFIVLMSHGI-L-------EGICGTAHDE-------- KNPDVLLYDTVFQIFNNRNCLNLKDKPKVIIVQACRG-------------KGRGEHW-VR ---DSPASLAVISSQSP---------------E-NLEEDSVCRVHVEKDFIA---FCSST PH--NMSWRDRTKGSIFITELITCFQK-------YS-WCYHLM--KIFQKVQKSFEIPMA K-----------AQMPTIERV----SLTRDFYLFPGN---------------- >E_caballus_ENSECAP00000021890 ------------------------------------------------------------ ----------TGNVLKEKRRLFIRSVGTGTVNS--L---------LDELLEKRVLNQEE- -------------------------------------------------M---------- -------EKVR------DENATVMDKARALIDAVIRKGPQACQIFIGHIC--EDDPHLAE TLRLSSG-----PQSGNFLKTQ-------------------------------------- -----------------------------------------------------------D SQAVVHSSPALQAM----------------------------PDDLAK------------ --LALSGP------KVS----------LKLCSPEVVERI----WKEKSAEMYPI-MGKSM TRTRLALIICNTEFD----------NLSRRAGAEVDIASMKVLLEGLGYSVE-VKENLTA LDMTTELKAFAARPE--HRSSDSTFLVFMSHGI-R-------EGICGKKFSE-------- KVPDVLEVNTIFQIFNTRNCPNLRDKPKVIIIQACRG-------------ENQGVVW-LK ---DSTGTSGSSSSLAP---------------D-DFEDDAIKKAHVEKDFIA---FCSST PD--TVSWRSPTTGSVFIEKLIENLQE-------YA-WSCDLE--EIFRKVRLSFELPDA R-----------AQMPTAERV----TLTRRFYLFPGY---------------- >O_anatinus_ENSOANP00000016591 ------------------------------------------------------------ ---------PPAQLLKDRWCLIIESLTHGMISG--L---------LDDLLQMQVINQEE- -------------------------------------------------M---------- -------DTVR------EEHHRPAEKTRALLNSVIPKGDLASQIFIDSLC--KKNPFVAA KLGLSAG-----GQGQSGNTQFVGQSQ--------------------------------- -----------------------------------------------------------M IPAVATSCSVPQALQA--------------------------PKTLTE------------ --SHPDGS------GEI----------LKLCPSEEREKL----QKENEGEIYPV-LVKA- GRQRQALIICNIKFE----------ELCERVGAELDIKGMKKLLEDLDYTVQ-VERNLSA TEMESKLKMFAGRPE--HKFSDSTFLVFMSHGI-L-------EGICGTKYKK-------- QEPDVLSYSTIFRVFNNINCPGLKDKPKIIIVQACRG-------------ENEGMAW-VS ---DSLGPSAT-SSQEP---------------E-DLENDAIHRTHVEKDLIA---FCSST PD--HVSWRDPKTGSLFIVQLIKCFQN-------HA-WNCDLE--SLFLKVQRHFETPKQ K-----------LQMPTRERA----TLTKRFFLFPGH---------------- >P_pygmaeus_ENSPPYP00000004377 ------------------------------------------------------------ ---------MADKVLKEKRKLFIRSMGEGTING--L---------LDELLQTRVLNKEE- -------------------------------------------------T---------- -------EKVK------RENATVMDKTRALLDSLIPKGARACEICITYIC--EEDSYLAE TLGLSAD-----QTSGNYLNMQ-------------------------------------- -----------------------------------------------------------D SQGVLSSFPAPQAV----------------------------QDNPAM------------ --PTSSGS------KGN----------VKLCSLKEAQKI----WKEKPAEIYPI-MDKS- SRTRLALIICNEEFD----------SIPRRTGAEVDITGMTMLLQNLGYSVD-VKKNLTA SDMTTELKAFAHRPE--HKTSDSTFLVFMSHGI-R-------EGICGKKHSE-------- QVPDVLQLNEIFKMLNTKNCPSLKDKPKVIIIQACRG-------------DSHGVVW-LK ---DSVGVSRNISLPTT---------------E-EFEDDAIKKAHIEKDFIA---FCSST PD--NVSWRHPTMGSVFIMRLIQHMQE-------YA-CSCDVE--EIFRKVRFSFEQPDG R-----------AQMPTTERV----TLTRCFYLFPGH---------------- >E_caballus_ENSECAP00000006810 ------------------------------------------------------------ --------LAGRGPEKEDPVNLMKSIARNMFEG--F---------LDDL-ENNVLSRDD- -------------------------------------------------L---------- -------RKLG------KRVNRIVNGTENLVEDLSEKTEVAGKIFLKHLL--KPKKQMNL KSLADYE-----DDESEDTES--------------------------------------- -----------------------------------------------------------P FSSTESACEGEDEETEENAGLSQASVPP--------------MTDPQE------------ --TQVSQP------KDK----------LKPCSHDHFRKL----KTTKAEEMYPV-MEKK- GRTRLALIICNKKFD----------YLSDRNGSEVDLVGMQDLLGNLGYSVV-VEENLTA LEMETALRHFAARQE--HRSSDSTFLVFMSHGD-L-------DGICGTKHNE-------- EEPDILHDDTIFQIFNNRNCRSLRDKPKIIIIQACRG-------------RGDGSVW-VT ---DTGVASAYSSDQPF---------------QGYIWNDAVTKTHVEKDFIA---FKSST PH--NISWRTDKTGSIFISKLIYNFRK-------YS-CCHHLE--EIFRKVQRSFEIPSV V-----------IQMPTIERV----SMTRYFYLFPGN---------------- >M_domestica_ENSMODP00000034022 ------------------------------------------------------------ ---------LTDKVLMEKRRLFVESVDRGVMNG--L---------LDDLLEVQVLNLEE- -------------------------------------------------M---------- -------EIVR------EESKTNRDKARVLIDAVISKGPKASQCFTKSIC--ERDGHLAE KLGLSSE-----LNSNQSHISLCREQAPRPINICILR----------------------- ------------------------------------------------------------ ------------------------------------------NDNIER------------ -TTMNPGY------LDT----------LKLCSYEDFQQK----RKEMEGQIYPV-MEKG- FRTRLALIICNKEFD----------ELPRRNGAENDVTGMQNLLEGLGYRVH-VKENLTA LEMESALKQFASYPE--HRTSDSTFLVLMSHGV-P-------GGICGKDYTD-------- KVPQILDVNKIFQIFNTSNCPTLKDKPKIIILQACRG-------------ENDGVVW-VN ---DSSKSSQQRCSQNL---------------P-IFEDDAVRRAHVEKDFIA---FCSST PD--NISWRNIYKGSLFIIQLILYIKK-------FA-WCYHLY--EIFCKVQHSFETPAE K-----------LQMPTIERA----TLTKYFYLFPGN---------------- >P_troglodytes_ENSPTRP00000059619 ------------------------------------------------------------ ---------MADKFLKEKRKLFIRSMGEGTING--L---------LDELLQTRVLNQEE- -------------------------------------------------M---------- -------EKVK------RENATAMDKTRALIDSVIPKGAQACQICITYIC--EEDNYLAG TLGLSAD-----QTSGNYLNMQ-------------------------------------- -----------------------------------------------------------D SQGVLSSFPAPQAV----------------------------QDNPAM------------ --PTSSGS------EGN----------VKLCSLEEAQRI----WKEKSAEIYPI-MDKS- SRTRLALIICNEEFD----------TIPRRTGAEVDITGMTMLLQNLGYSVD-VKKNLTA SDMTTELKAFAHRPE--HKTSDSTFLVFMSHGI-R-------EGICGKKYSE-------- QVPDVLQLNAIFNMLNTKNCPSLKDKPKVIIIQACRG-------------DSPGVVW-FK ---DSVGVSGNLSLPTT---------------E-EFEDDAIKKAHIEKDFIA---FCSST PD--NVSWRHPTMGSVFIGRLIEHMQE-------YA-CSCDVE--EIFRKVRFSFEQPDG R-----------AQMPTTERV----TLTRCFYLFPGH---------------- >H_sapiens_ENSP00000260309 ------------------------------------------------------------ ---------MADKVLKEKRKLFIRSMGEGTING--L---------LDELLQTRVLNKEE- -------------------------------------------------M---------- -------EKVK------RENATVMDKTRALIDSVIPKGAQACQICITYIC--EEDSYLAG TLGLSAD-----QTSGNYLNMQ-------------------------------------- -----------------------------------------------------------D SQGVLSSFPAPQAV----------------------------QDNPAM------------ --PTSSGS------EGN----------VKLCSLEEAQRI----WKQKSAEIYPI-MDKS- SRTRLALIICNEEFD----------SIPRRTGAEVDITGMTMLLQNLGYSVD-VKKNLTA SDMTTELEAFAHRPE--HKTSDSTFLVFMSHGI-R-------EGICGKKHSE-------- QVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRG-------------DSPGVVW-FK ---DSVGVSGNLSLPTT---------------E-EFEDDAIKKAHIEKDFIA---FCSST PD--NVSWRHPTMGSVFIGRLIEHMQE-------YA-CSCDVE--EIFRKVRFSFEQPDG R-----------AQMPTTERV----TLTRCFYLFPGH---------------- >M_domestica_ENSMODP00000034033 ------------------------------------------------------------ ---------LTDKVLKEKRRLFVESVDRGVING--L---------LDDLLELQVLNLEE- -------------------------------------------------M---------- -------EILK------EESRTIRDKARVLIDAIISKGPKASQCFTKSIW--ERDGHLAE KLGLSS--------GKRKYLLGKADHSIHGEKLKTKQ----------------------- ------------------------------------------------------------ ------------------------------------------RHTIGK------------ WKVIHDDA------IDT----------LKLCSYADFQRI----KKEKEGQIYPV-MEKG- FRTRLALIICNKEFD----------ELPRRNGAENDVTGMQNLLEGLGYRVH-VKENLTA LEMESALKQFASYPE--HRTSDSTFLVLMSHGV-P-------GGICGKDYRE-------- KDPQILDVNKIFQIFNTSNCPNLKDKPKILILQACRG-------------ENDGAVL-VN ---DSSDSSEHRCIQNL---------------P-IFEDDAVRRAHVEKDFIA---FCSST PD--NVSWRNIYKGSLFIIQLILYIKK-------FA-WCYHLY--EIFCKVQHSFENREE K-----------LQMPTIERA----TLTKYFYLFPGN---------------- >M_domestica_ENSMODP00000034020 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LIAS------------ --TAQTGS------SGK----------LKVCSREEFLMQ----RRLRVEEIYPV-MEKG- SRTRLALIICNKKFE----------NISERHGAEIDTIGMKTLLEDLDYNVY-VKENLTS LEMESALKEFASHPD--HQLSDSTFVVLMSHGV-R-------HGICGIKHKN-------- EDPDVFLYETMYEILNTRNCPNLKDKPKIIIVQACRG-------------DNYGEVW-VN ---DSSASCAD-SPKEL---------------Q-VFDHDAVSRAHSEKDFIA---FHSST PN--NVSWRHPRNGSVFITKLIHYFQQ-------YC-WCYHIE--EIFRKVQNAFETPEY K-----------FQMPTIERL----SMTRYFYLFPGN---------------- >B_taurus_ENSBTAP00000027821 ------------------------------------------------------------ ----------------EKRKLFVHSVSKGTING--L---------LDELLEKRVLNQEE- -------------------------------------------------M---------- -------EKIR------DENDTAMDRARVLIDTVIRKGPQACQICISHIC--EEDSHLAG ILGLTSG-----SQSENYLR-Q-------------------------------------- -----------------------------------------------------------K PQAVVPPFPAPQAM----------------------------LDNPVK------------ --LASSGP------GGN----------LKLCPPETAQRI----RKEKSGEIYPI-MERS- NRTRLALIICNTEFE----------NLTRRDGADVDTRNMKVLLEGLGYKVD-VKENLTA SEMILELKAFAAHSE--HRTSDSTFLVFMSHGI-R-------AGICGKKYSE-------- EVPDILKVDDIFHILNTGNCPALKDKPKVIIIQACRG-------------EKQGMVW-VN ---DSVAASGNCSLVAP---------------E-DFESDAIKKAHIEKDFIA---FCSST PD--NVSWRHPIFGSLFIIKLIETFQE-------YA-WSCDLE--EIFRKVRFSFELPDG K-----------VQMPTAERV----TLTRCFYLFPGY---------------- >C_familiaris_ENSCAFP00000021904 ------------------------------------------------------------ --------VLTGKRQSQDPVNAIKVVASTMLNS--F---------LEDLKEKNVLNKQE- -------------------------------------------------L---------- -------QTMG------QTVNVITKKTENLVGDLTEKTQVVGKIFKDHFL--NSGSLLSL SWSSTSA-----TKPSGSCRPS-------------------------------------- -----------------------------------------------------------Y LTQARSRKKEEVPKILVFVIFLYKMVFL--------------LQVLQ------------- --EIQASQ------VKV----------RKLCPCDHSHEP----KITNVHEIYPV-MEKE- GRTRLALIICNSEFD----------YLSKRQGSEIDILGMQDLLENLGYSVV-VKENLSA LEMKTELKNFAARQE--HKFSDSTFLVFMSHGT-L-------DGICGTKHRN-------- EEPDILHDDTIFQIFNNRNCRSLKDKPKVIIMQACRG-------------RGDGAVW-VT ---DVGEASAWTCDQPL---------------QCYIFNDAIEKTHVEKDFIA---FKSST PH--NVSWRLNTDGSLFISHLIHYFRE-------FS-CCHHLE--EIFRKVQNSFETPNT M-----------IQMPTIERV----SMTRYFYLFPGN---------------- >R_norvegicus_ENSRNOP00000029448 ------------------------------------------------------------ --------FTAKRTHERDPIYKIKGLAKDMLDG--V---------FDDLMDKNVLNGDE- -------------------------------------------------L---------- -------LKIG------EGASLILSKAENLVESFFEKTEMAGKIFAGHIA--NSDKQLSL LQADRNQ-----ITGPSFQILV-------------------------------------- -----------------------------------------------------------F NSLSESRGKVEDEEMEVNVGVAHASHLM--------------LTVPQG------------ --IQSTEV------QDS----------LKLCSRDWFCTM----KTERAEEIYPV-MEKE- GRTRLALIICNKKFD----------YLFDRDDAETDILNMKELLQNLGYSVV-IKENLTA QEMETELMKFAGRPE--HQSSDSTFLVFMSHGI-L-------EGICGVKHRN-------- KKPDVLHDDTIFTIFNNSNCPSLRNKPKILIMQACRG-------------RHTGTIWVST ---SKGIATADTDEECV---------------LSHRWNNSITKAHVETDFIA---FKSST PH--NISWKVGKSGSLFISKLIDCFKK-------YC-WCYHLE--EIFRKVQYSFEVPGE L-----------TQMPTIERV----SMTRYFYLFPGN---------------- >M_musculus_ENSMUSP00000027009 ------------------------------------------------------------ --------MAARRTHERDPIYKIKGLAKDMLDG--V---------FDDLVEKNVLNGDE- -------------------------------------------------L---------- -------LKIG------ESASFILNKAENLVENFLEKTDMAGKIFAGHIA--NSQEQLSL -QFSNDE-----DDGPQ-KICT-------------------------------------- -----------------------------------------------------------P SSPSESKRKVEDDEMEVNAGLAHESHLM--------------LTAPHG------------ --LQSSEV------QDT----------LKLCPRDQFCKI----KTERAKEIYPV-MEKE- GRTRLALIICNKKFD----------YLFDRDNADTDILNMQELLENLGYSVV-LKENLTA QEMETELMQFAGRPE--HQSSDSTFLVFMSHGI-L-------EGICGVKHRN-------- KKPDVLHDDTIFKIFNNSNCRSLRNKPKILIMQACRG-------------RYNGTIWVST ---NKGIATADTDEERV---------------LSCKWNNSITKAHVETDFIA---FKSST PH--NISWKVGKTGSLFISKLIDCFKK-------YC-WCYHLE--EIFRKVQHSFEVPGE L-----------TQMPTIERV----SMTRYFYLFPGN---------------- >M_musculus_ENSMUSP00000027015 ------------------------------------------------------------ ---------MADKILRAKRKQFINSVSIGTING--L---------LDELLEKRVLNQEE- -------------------------------------------------M---------- -------DKIK------LANITAMDKARDLCDHVSKKGPQASQIFITYIC--NEDCYLAG ILELQSA-----PSAETFVATE-------------------------------------- ------------------------------------------------------------ DSKGGHPSSSETKE----------------------------EQNKED------------ --GTFPGL------TGT----------LKFCPLEKAQKL----WKENPSEIYPI-MNTT- TRTRLALIICNTEFQ----------HLSPRVGAQVDLREMKLLLEDLGYTVK-VKENLTA LEMVKEVKEFAACPE--HKTSDSTFLVFMSHGI-Q-------EGICGTTYSN-------- EVSDILKVDTIFQMMNTLKCPSLKDKPKVIIIQACRG-------------EKQGVVL-LK ---DSVRDSEE-DFLTD---------------A-IFEDDGIKKAHIEKDFIA---FCSST PD--NVSWRHPVRGSLFIESLIKHMKE-------YA-WSCDLE--DIFRKVRFSFEQPEF R-----------LQMPTADRV----TLTKRFYLFPGH---------------- >P_pygmaeus_ENSPPYP00000004372 ------------------------------------------------------------ --------FTDEKPSNGVPVHMVKLLIRTFLDG--I---------FDDLMENNVLNTDE- -------------------------------------------------I---------- -------HLIG------TCLKFVVSNAENLVDDITQTAQIAGKIFREHLW--NSKKQLSS ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------DISSD-GER-- GPNTPGLIICNKEFN----------YLHNRNGSELDLLGMQDLLENLGYSVV-IKENLTA QEMETALRQFAARPE--HQTSDSTFLVFMSHGI-L-------NGICGTKHWD-------- QEPDVLHDDTIFEIFNNRNCRSLKDKPKVIIMQACRG-------------NGAGIVWFTI ---DSGKASADTHGRLL---------------QGNICNDAVTKAHVEKDFIA---FKSST PH--NVSWRHEINGSVFISQIIYYFKE-------YS-WSHHLE--EIFRKVQHSFENPSI L-----------TQLPTIERL----SMTRYFYLFPGN---------------- >M_mulatta_ENSMMUP00000021744 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LSAPLE------------ --IQGAQP------SGR----------LKLCPHAHFREL----KTKRADEIYPV-MEKE- GRTRLALIICNKEFH----------YLLNRNGSELDLLGMQDLLENLGYSVV-IEENLTA QEMETALRQFAARPE--HQSSDSTFLVFMSHGI-L-------NGICGTEHWD-------- QEPDVLHDDTIFEIFNNRNCRSLRDKPKVIIMQACRG-------------SGAGIVWFTT ---DSGKASAETHGQLL---------------QSSICNDAVTKAHVEKDFIA---FKSST PH--NVSWRHEISGSVFISQIIYYFKE-------YS-WSHHLE--EIFRKFERSFETPNV V-----------TQLPTIMLI----SIFIYFILF------------------- >P_troglodytes_ENSPTRP00000047678 ------------------------------------------------------------ --------MADEKPSNGVLVHMVKLLIKTFLDG--I---------FDDLMENNVLNTDE- -------------------------------------------------I---------- -------HLIG------KCLKFVVSNAENLVDDITETAQIAGKIFREHLW--NSKKQLSS ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------DISSD-GER-- GANMPGLNICNKEFN----------YLHNRNGSELDLLGMRDLLENLGYSVV-IKENLTA QEMETALRQFAAHPE--HQSSDSTFLVFMSHGI-L-------NGICGTKHWD-------- QEPDVLHDDTIFEIFNNRNCQSLKDKPKVVIMQACRG-------------NGAGIVWFTT ---DSGKASADTHGRLL---------------QGNICNDAVTKAHVEKDFIA---FKSST PH--NVSWRHETNGSVFISQIIYYFKE-------YS-WSHHLE--EIFRKVQHSFETLNI L-----------TQLPTIERL----SMTRYFYLFPGN---------------- >O_cuniculus_ENSOCUP00000000956 ------------------------------------------------------------ ---------MADRILKDRRKRFINSVGTGTING--L---------LDELLEKRVLNQEE- -------------------------------------------------M---------- -------EKVR------VENATVMDKARALLDCVIRKGPQACQICINHIC--EDDCHLAG LLGLSSG-----PQSENHFNAQ-------------------------------------- -----------------------------------------------------------D SLEAFSSFSAPQTT----------------------------QDNQVV------------ --FTFSGP--------S----------LKLCPLETAQRI----WKEKSEEIYPIKMQSS- GRTRLALIICNTEFD----------SLPRRTGADVDIRDMKMLLIGLGYSVD-VKENLNA LDMATELKAFADRPE--HWTSDSTFLVFMSHGT-R-------DGICGKNYSE-------- QYSDILNVNTIFEMLNTKNCQSLKDKPKVIIIQACRG-------------ENQGIVW-LK ---DSIGDSGNTSLLNP---------------D-DFEYDASRIAHIEKDFIA---FCSST PD--NVSWRHPKQGSLFIMRLIKTMQE-------YA-WSCDVE--EIFRKVRFSFELPEG R-----------TQMPTTERV------MRRFYLFP-H---------------- >R_norvegicus_ENSRNOP00000009993 ------------------------------------------------------------ ---------MADKILRAKRKQFINSVSVGTING--L---------LDELLEKRVLNQEE- -------------------------------------------------M---------- -------DTIK------LANITVMEKARDLCDHVTKKGPRASQMFITYIC--NEDCYLAE ILELQSG-----PSAETVFVTE-------------------------------------- ------------------------------------------------------------ DSKGGHPFSSETKE----------------------------KLNKEG------------ --GAFPGP------SGS----------LKFCPLEIAQKL----WKENHSEIYPI-MKTP- TRTRLALIICNTDFQ----------HLSRRVGADVDLREMKLLLQDLGYTVK-VKENLTA LEMTKELKEFAACPE--HKTSDSTFLVFMSHGL-Q-------EGICGITYSN-------- EVADILKVDTIFQMMNTLKCPSLKDKPKVIIIQACRG-------------EKQGVVL-LK ---DSVGNSEE-GFLTD---------------A-IFEDDGIKKAHIEKDFIA---FCSST PD--NVSWRHPVQGSLFIESLIKHMKE-------YA-WSCDLE--DIFRKVRFSFEQPDS R-----------LQMPTTERV----TLTKRFYLFPGH---------------- >H_sapiens_ENSP00000364878 ------------------------------------------------------------ --------MADEKPSNGVLVHMVKLLIKTFLDG--I---------FDDLMENNVLNTDE- -------------------------------------------------I---------- -------HLIG------KCLKFVVSNAENLVDDITETAQTAGKIFREHLW--NSKKQLSS ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------DISSD-GER-- EANMPGLNIRNKEFN----------YLHNRNGSELDLLGMRDLLENLGYSVV-IKENLTA QEMETALRQFAAHPE--HQSSDSTFLVFMSHSI-L-------NGICGTKHWD-------- QEPDVLHDDTIFEIFNNRNCQSLKDKPKVIIMQACRG-------------NGAGIVWFTT ---DSGKAGADTHGRLL---------------QGNICNDAVTKAHVEKDFIA---FKSST PH--NVSWRHETNGSVFISQIIYYFRE-------YS-WSHHLE--EIFQKVQHSFETPNI L-----------TQLPTIERL----SMTRYFYLFPGN---------------- >G_gallus_ENSGALP00000001569 ------------------------------------------------------------ --------------LLRVRADFVSRVRKAVVSN--L---------LDELLAHRVLNQAE- -------------------------------------------------V---------- -------DEVQ------EGNPVTTDKARSLIDTVRLKGPRASAIFIDSLR--KHDCNLAE QLRLCAH-----AEPPGAPLAAPSTVGFSDP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --PVSSQD------LQW----------IQQCPLSEYQRI----KEAEGDQIYDIYQPRE- RRTRRALLICNTKFK----------HLRQRDGAEVDVKEMTKLLEGLGYNVE-CHEDKTS QEMTTVMKKFADHKD--HLTSDSTFLVFMSHGM-S-------TGICGTKSN--------- GTTDILSFNTIYENFNNKHCRALMGKPKVVIIQCCRG-------------DNIGSVQ-IR ---DSIDPEMPTSTSDG-------------WRCVELQGSKTREAHLESDFAT---LYSST PD--TVSWRSPTEGSVFIQRLVEQFRN-------HA-FNSDLQ--EMFRKVQRSFENFP- ------------RQLPTQERT----TMLKKFYLFPGL---------------- >M_mulatta_ENSMMUP00000012901 ------------------------------------------------------------ ----------TDKVLKEKRKLFIHSMGEASL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AM----------------------------QDNPAM------------ --PTSSGS------KGN----------VKLCSQEEAQRI----WKEKPAEIYPI-MVKS- GRTRLALIICNEEFD----------TLPRRTGAEVDITGMTMLLQNLGYSVD-VRKNLMA SEMTTELEAFAHRPE--HKTSDSAFLVFMSHGI-R-------EGICGKKYSE-------- QVPDVLQLNVIFEMLNTRNCPSLKDKPKVIIIQACRG----------------------- ------------------------------------------------------------ -D--NVSWRHPTKGSVFIIRLIEHIQE-------YA-CSCDVE--EIFRKVRLSFEQPSG R-----------VQMPTTERV----TLTRCFYLFPGH---------------- >X_tropicalis_ENSXETP00000017024 ------------------------------------------------------------ ----------LAAQLKKVRKLFIDGCNAAIINN--L---------LDDLLDKSVLTDSE- -------------------------------------------------V---------- -------EYIN------ECNAITKDRCRRMIDNIKNKGDYSSNILLQCLV--ENHKTLAK NMGLDVS-----EPAIAPQPIQEQNKK--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --TNENTE------ISS----------VIHCSDKDFKEI----HDTQGDKIYEM-RKRE- GRKRFALIICNEKFE----------TLTERQGAKVDLDGMTKLLNELGYQVL-QETNLAK EEMLKVLKEFAAREE--HVDSDSTFIVLMSHGD-K-------PGVCGTDSKKIEHEKGQC QVTNLLQTDEIFSIFNNIHCPKLRDKPKVIIIQACRG-------------EERGQKL-VC ---DAVALPPEE----------------------QLEDDALHRVQRETDFIC---FCSST PD--TVSWRHPTMGSLFITGLIKKMNE-------LA-HCQPLM--DIFLEVQSSFKGQ-- ------------RQMPTQERS----TLTKKFYLFPGH---------------- >O_cuniculus_ENSOCUP00000006490 ------------------------------------------------------------ ---------------YKDVLKEMESAGKAIAGS--F---------MDNLVKKKVIKLEK- -------------------------------------------------A---------- -------KREK------FYDAKTHKKAQILVDSLREKCHEEDQKLTETFL--NIDQNSTG MQXXXXX-----XXXX-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --XXXXXX------XXX----------XXXXXXXXXXXX----XXXXXXXIYPI-KDKK- DRTRLALIICNIEFQ----------HLPLRNGAQFDISGMKRLLEDLGYSVV-VKVKLTA KAMESVLQEFAARPE--HNSSDSTFVVLMSHGI-L-------DGICGIMHSD-------- KTQDVLPYDTVFRTLNNRNCISLRDKPKVIIVQACRG-------------XXXXXXX-XX ---XXXXXXXXXXXXXX---------------X-XXXXXXXXXXXXXXXXXX---XXXXX XX--NLS----------------------------------------------------- ----------------------------------------------------- >G_aculeatus_ENSGACP00000013201 ------------------------------------------------------------ ---------YFSDKLKKVRTKFVEKASMSLIKQ--L---------LDDLLDNGILNDGQ- -------------------------------------------------K---------- -------DSIL------EENGTKADRARNLIDVVKAKGNKASEILIASLE--SRDSSLFS ELGLSSA-----QTAPPAISGVSNIF---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------KLVSPHRDRKLT----PLKSVFQIYPA-SKNS- ISNRVALLITNIKFT---------YEIPNRNGAEKDEENMEILMKGLGYEVV-KHRNLTA KAIDEALKEFAKHPK--LKKTDSVLVVLMSH--------------CGVDWKRE------- RKADEFPIDNIYKHLGPENCPALLDKPKIIIIQACRG-------------GDEGAVV-VR ---DGDGPALACDDAGE----------------EDIEDDNLRLVNKEKDFSS---LLSCT PD--TVSYRHPVNGSFLIQYVVEVFNT-------FA-REDHVE--ELFRKVMQRFEDFPI Q---------REKQMPTKDRC----TLTKHFYFFPGL---------------- >D_rerio_ENSDARP00000034228 ------------------------------------------------------------ -------------MAKSIKDHLQDALSNIGADN------------LRRFQSRLGDRKQE- -------------------------------------------------P---------- -------RVRK------STIEKLKDEIDLVDLLVNTFTSDAVSVTVDILR--GIKCNAVA EELLENT-----GQVYSIFKLCKKNSHYTKPPIIITDVFMFCFLGGVSQP---------- ------------------------------------------------------------ ------------------------------------------------------------ --EPPVPE------PIPKDPAQLKELKVTPCSQQFKNKI----LREKGQETYEI-KDKS- VRKRLALLINNVDFD---------DKAMKRSGSEKDEENMEKLLKELDYQVV-KRPNLSA KEMDEAIRDFAQREE--HKYSDSAFVVIMSHGK-R-------DAIMGVHYHRTN------ NPSDSFPVDNVYRRLNSENCPALRDKPKVILIQACRG-------------GEHGRVW-AS ---DGEPDE-------------------------PIEIEDDDFVHKEKDFIS---LMSCT PD--TKSYRHVQNGTFYVQTLVDVFIK-------CA-HEDHIE--ELFRKVLRRFEHPNM I--------GNFKQMACKDRA----TLPKLFYLFPGL---------------- >A_carolinensis_ENSACAP00000013361 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AMQIYPI-GDRR- SRTRLALIICNITFA----------HLNKREGAEVDLRGMTLLLEDLGYRVE-IKINLTA KEMSTCLKDFAAREE--HKTSDSTFLVLMSHGV-R-------DGLCGVQSRD-------- KDSDVLPIDDVFSIFNNNNCRALYEKPKVVIIQACRG-------------TNKGVTY-VS ---DSVVPVVPSADSAS-------------SSA-NYEEDAVRMVHLESDFIC---LYSTT ------------------------------------------------------------ ----------------------------------------------------- >T_rubripes_ENSTRUP00000019853 ------------------------------------------------------------ ---------LP-DQLASIRPMFVEKVSTQMINQ--L---------LDDIFMDGIVSEME- -------------------------------------------------K---------- -------ESIT------EESNIRSDKARRLIDSVRKKGERACKKMISHIQ--SRDPELSA VLGLSCG-----HPAPP--------GELRDDTLFQTDRIVSFRF-----QP--------- ------------------------------------------------------------ ------------------------------------------------------------ --QSPRWK------VKG----------HLQLPHQSMCSG----RRNRATKVYPG-TREA- ISNRVALVITNITFF---------HQCLNRKGAEKDEENMETLLKGLGYEVV-KYRNLTG RAIEEAIIDFSKRPK--LKDTDSVVVVIMSHGR-M-------GVVAGVSTLSKT------ FEDDLFSLDKIYRLLGPEHCPALLNKPKIIIIQACRG-------------DEGGEII-CN ---DQHPPENPPVSDDA-----------------NIQEDAIRIEHTEKDSIC---FFSCT PN--TVSYRSPAKGSFLVQFLVDVFNA-------SA-ERDDLE--ELFRKVQRRFEDYSI G-------DRSLRQMPAKDRG----TMTKRFYFYPGL---------------- >T_rubripes_ENSTRUP00000013027 ------------------------------------------------------------ ---------MAICQLDSIRLMFVEKVSTQMINQ--L---------LDDIFMDGIVSEME- -------------------------------------------------K---------- -------ESIT------EESNIRSDKARRLIDLVRKKGERACKKMISHIQ--SRDPELSA VLGLSCG-----HPAPP--------GELR-------GQLESPAF-----ST--------- ------------------------------------------------------------ ------------------------------------------------------------ --AEPQME------GQG----------SSSTP-PSIDVF----WKEKQSDVYPG-TREA- INNRVALVITNITFF---------------QGAEKDEENMETLLKGLGYEVV-KYRNLTG RAIEDAVIDFSKRPK--LKDTDSVVVVIMSHGR-L-------GVVAGVSTQSPT------ FEDDHFSLDKMYRLLGPEHCPALLNKPKIIIIQACRG-------------DERGEII-FN ---DQHPPENPPVSDDA-----------------NIQEDAIRIEHKEKDFVS---LLSCT PD--TVSYRALAKGSFLVQVLVDVFNA-------SV-ERDDLE--ELFRKVQHRFEDFPI G-------NR--RQMPTKDRC----TLTKRFYFYPGL---------------- >T_rubripes_ENSTRUP00000035020 ------------------------------------------------------------ ---------ME-DKLTSIRLMFVEKVSTQMINQ--L---------LDDIFMDGIVSEME- -------------------------------------------------K---------- -------ESIT------EESNIRSDKARRLIDSVRKKGERACKKMISHIQ--SRDPELSA VLGLSCG-----HPAPPVFNRRAPDGRSR-------VIFNSPINRCVLEGE--------- ------------------------------------------------------------ ------------------------------------------------------------ --TERQRR------ERA----------LKISP-GNHSLL----LQSFQ--VYPG-TREA- INNRVALVITNITFF---------HQCLNRKGAEKDEENMETLLKGLGYEVV-KYRNLTG RAIEDAVIDFSKRPK--LKDTDSVVVVIMSHGR-L-------GVVAGVSTQSPT------ FEDDLFSLDKIYRHLGPEHCPALLNKPKIIIIQACRG-------------DERGEII-FN ---DQHPPENPPVSDDA-----------------NIQEDAIRIEHKEKDFIW---LLSCT PD--TVSYRALAKGSFLVQVLVDVFNA-------SA-ERDDLE--ELFRKVQHRFEDFPI G-------NR--RQMPTRDRC----TLTKRFYFYPGL---------------- >O_latipes_ENSORLP00000007938 ------------------------------------------------------------ -----------------------------------------------MLLQDKVLNDEE- -------------------------------------------------R---------- -------ESIC------EE-KSRADMARSLIDTVRKKGSTASKMMINHFE--QKDPILFS ELGLSCP-----EPAQT------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --NSHSQR------DEP----------ATTVLTAEDFWK----KTQNDPNVYPV-TKAS- YKSRVALMITNIKFS---------NEKLNRAGAEKDEENMDRLLSKLGYEVV-KHKSLTG KAINEAFIEFTKHPK--LKETDSVIVVLMSHGK-L-------GAVLGVEWKHDD------ ENPDEFPVNSIYEHLGPEKCPALLDKPKIIIIQACRG-------------DQTGSVC-IS ---DSGNQAEEFLHPAA---------------AGDLLEDNLRFVHKEKDFIS---LLSCT PD--TKAFRCRARGSHLIQYIVEIFNT-------DA-DTLYIQ--ELFRKVMLRFESFAF K---------HNRQMATIERC----TLLKQFYFYPGLGDTNH----S------ >D_rerio_ENSDARP00000059407 ------------------------------------------------------------ -------------KMEDITKLITDVLEELVESE--L---------KEFKRQLWMGVKKG- -------------------------------------------------V---------- -------EAIP------RGKLENKDRQDVVDYMVQHYSMDAGKIAVQALR--SIKQNERA NRLESKL-----LEAVSSSDLFQPQAQENEQNPEDP----------------QSINTSG- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------FQEFKTRL----LYANRDDIYTP-VSRT- QRKGLALLITNILFA---------NKQDDRAGAERDEENMEWLLKNLNFMVI-KYRNLTG NEISRAVQDFSRRHE--HQDADSTFVVIMSHGD-R---IQNKDAILGVNYNWLQ------ NRNDVYFVEDTFSHLNSVNCPALIDKPKVILIQACRG-------------GQLGGVP-VK ---DCVPE-------------------------------SDSWVHKEKDFVC---FMSTM PD--VVAYRDEVKGSYFISYIVDVFCS-------SA-CKDHIM--ELFRKVAARMEKDER F-------RRQAKLLPCIERT----SLVKKFYLFPGQ---------------- >D_rerio_ENSDARP00000008601 ------------------------------------------------------------ ---------MTEEVNWDEDLEVDAVVQNLNLYKTVM---------RNDKNSNSEVQLSN- -------------------------------------------------ELVDFAVELTC GHRMPVDYVVAWFKCYLKQKETDFSCPHFIVDQGKTCGAKLSYQEICQLIPLSDKQREFL EENLAAI-----VARRLFDFKSCPGCQ--------------------------------- -----------------------------------------------------------S HVERRNRNNLCVKCTICTANMTQTYYFCWKCRREWKGVTNNAECCGNT------------ GCGQSVTE------PDP----------LKPCTPEFKAEK----LMTEGKCIYPV-KDKSP QRKRLALLINNVDFK-----------DNVRTGADKDELSMERLLKGLGYSVV-TLRDLSA QGMSTAMRDFSQRKE--HADSDSCFVVLMSHGD-E-------SGICGIFDSS-------- SQDDVFPPDEIFKYLNTPNCAGLRDKPKIILIQSCRG-------------GKPGNVD-VP ---DSVPI------------------------------RGTRREHKEKDFCC---FRSST PV--TVS--------------------------------------DPLLQGK-------- ----------------------------------------------------- >D_rerio_ENSDARP00000068268 ------------------------------------------------------------ --------------MEDITQLLSDVLEDLVESE--L---------KQFTRQLWIGVKPG- -------------------------------------------------V---------- -------EPIP------RGKLENKDRQDVVDSMVQQYSEDAGTITVQTLR--KIKQNERA KRLESNL-----LKV-------QSQGQENKQNSEEPQPIPQIISQPIQQIISQPINNAGS EDLQPI------------------------------------------------------ ------------------------------------------------------------ --QADWQR------PRQ----------IIPCSQETKNTL----LKAHGDDIYTP-RSGT- QRKGLALLITNIQFA---------NTQHNRNGADRDEENAEWLLRSLGFAVI-KYRNLSG KDIRRAVENFSKRRE--HEDADSTFIVIMSHGT-R---IDNKDAIVGVS----------- --DDVYFIEETFSHLNSVNCPALIDKPKVILIQACRG-------------GQSSGVL-AQ ---DSVFA-------------------------------SDSWVHMEKDFVC---FMSTM PN--TFAYRNPIEGSFFISYIVDVFCS-------SA-HRDDIM--ELFRKVTLRMEKDQR F-------QGQAKLLPCIERT----SISKRFYLFPGL---------------- >X_tropicalis_ENSXETP00000015203 ------------------------------------------------------------ -----MLGGMQKHHKDALQRLRVTLLHDMIIEEL-----------VEHLVSSGILTPIM- ------------------------------------------------------------ -----HSTIMA--------HRSEYKQNVTLLTQLPKRGPRAFSEFCNALH--ATGQRHLA EQLEEEA----------------------------------------------------- ------------------------------------------------------------ ---------------------QQQQMESVTPEVHERSFPLP-VQESTP------------ SRPRRQFC-----REYNEESIDDGDGPGT--VQLCSVDF----YLSHHQQAYKM---HS- CPRGRALIISNVAFE--------TQDLDHRYGGEVDVTSLEKLFSSLGFQVE-VRRNLNA QNMMSQLGAFSALPA--HSALDSCVVAVLSHGL-D-------GAVYGTD----------- --GKLVQLQDVFTAMDNAHCPQLQNKPKMFFIQACRG-------------EEADRGV-DQ ---RDGREQSASPGCEQSDAGR---------------EDIKVRLPTQSDMIC---AYACL KG--TVSLRNTKRGSWFVQDLVSVFSQ-------YS-KNTHVA--DMLVKVNALIKEREG H--APGTEFHRCKEMSEYCS-----TLCRDLYLFPG----------------- >E_caballus_ENSECAP00000003321 --------------------------------------MAAPSAPSLPALQQKGLMAADR GRRILGVCGMHPDHQEALKKNRVVLAKQLLLSEL-----------LEHLLEKDIITLEM- ------------------------------------------------------------ -----RELIQA--------KVTSFGQNVELLNLLPKRGPQAFEAFCVALR--ETKQGHLE DLLLTTL----------------------------------------------------- -----------------------------------------------------------S G--LQHV--LPP-----------------LSCDYDLSLPFP-VCESCP------------ PHKQLRLS-----TDTVEHSLDNGDGPPCLQVKPCTPEF----YQAHYQLAYRL---QS- RPRGLALVLSNVHFT-------GEKDLEFRSGGDVDHSTLVTLFKLLGYNVH-VLLDQTA KEMQEKLQNFAQLPA--HRVTDSCIVALLSHGV-E-------GGIYGVD----------- --GKLLQLQEVFRLFDNANCPSLQNKPKMFFIQACRG-------------DETDRGV-DQ ---QDGKNHAKSPECEESDAGK--------------EELLKMRLPTRSDMIC---GYACL KG--TAAMRNTKRGSWYIEALTQVFSE-------RA-CDMHVA--DMLVKVNALIKEREG Y--APGTEFHRCKEMSEYCS-----TLCRHLYLFPGHPPT------------- >G_gallus_ENSGALP00000029853 ------------------------------------------------------------ -----GACGMQRYHQEALKKNRVMLARELVLKEL-----------MEHMIEKDIITIEM- ------------------------------------------------------------ -----VEMIQA--------KSGSFSQNVEFLNLLPKRGPNAFSAFCEALQ--ETKQQHLA EMILKTE----------------------------------------------------- -----------------------------------------------------------S S--LRHG--IAT-----------------LEQRYGSNLPLP-LSESCN------------ SKRPRLIV--FFCTKPVEHSLDSGDGPPIPPVKHCTPEF----YRDHQHLAYKL---IS- EPRGLALILSNIHFS-------SEKDLEYRSGGDVDCASLELLFKHLGYQVT-VFHDQSA EEMESALERFSKLPD--HQDVDSCIVALLSHGV-E-------GGVYGTD----------- --GKLLQLQEAFRLFDNANCPNLQNKPKMFFIQACRG-------------DETDRGV-DQ ---RDGKEWSDSPGCEESDANK--------------EENLKLRLPTRSDMIC---GYACL KG--TAAMRNTKRGSWYIEALTTVFAE-------DS-RDTHVA--DMLVKVNRQIKQREG Y--APGTEFHRCKEMSEYCS-----TLCRDLYLFPGYVPGK------------ >H_sapiens_ENSP00000312664 --------------------------------------MAAPSAGSWSTFQHKELMAADR GRRILGVCGMHPHHQETLKKNRVVLAKQLLLSEL-----------LEHLLEKDIITLEM- ------------------------------------------------------------ -----RELIQA--------KVGSFSQNVELLNLLPKRGPQAFDAFCEALR--ETKQGHLE DMLLTTL----------------------------------------------------- -----------------------------------------------------------S G--LQHV--LPP-----------------LSCDYDLSLPFP-VCESCP------------ LYKKLRLS-----TDTVEHSLDNKDGPVCLQVKPCTPEF----YQTHFQLAYRL---QS- RPRGLALVLSNVHFT-------GEKELEFRSGGDVDHSTLVTLFKLLGYDVH-VLCDQTA QEMQEKLQNFAQLPA--HRVTDSCIVALLSHGV-E-------GAIYGVD----------- --GKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRG-------------DETDRGV-DQ ---QDGKNHAGSPGCEESDAGK--------------EKLPKMRLPTRSDMIC---GYACL KG--TAAMRNTKRGSWYIEALAQVFSE-------RA-CDMHVA--DMLVKVNALIKDREG Y--APGTEFHRCKEMSEYCS-----TLCRHLYLFPGHPPT------------- >P_troglodytes_ENSPTRP00000033921 --------------------------------------MAAPSAGSWSTFQHKELMAADR GRRILGVCGMHPHHQETLKKNRVVLAKQLLLSEL-----------LEHLLEKDIITLEM- ------------------------------------------------------------ -----RELIQA--------KVGSFSQNVELLNLLPKRGPQAFDAFCEALR--ETKQGHLE DMLLTTL----------------------------------------------------- -----------------------------------------------------------S G--LQHV--LPP-----------------LSCDYDLSLPFP-VCESCP------------ LYKKLRLS-----TDTVEHSLDNKDGPVCLQVKPCTPEF----YQTHFQLAYRL---QS- RPRGLALVLSNVHFT-------GEKELEFRSGGDVDHSTLVTLFKLLGYDVH-VLCDQTA QEMQEKLQNFAQLPA--HRVTDSCIVALLSHGV-E-------GAIYGVD----------- --GKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRG-------------DETDRGV-DQ ---QDGKNHAGSPGCEESDAGK--------------EKLPKMRLPTRSDMIC---GYACL KG--TAAMRNTKRGSWYIEALAQVFSE-------RA-CDMHVA--DMLVKVNALIKDREG Y--APGTEFHRCKEMSEYCS-----TLCRHLYLFPGHPPT------------- >M_mulatta_ENSMMUP00000016588 ------------------------------------------------------------ --RILGVCGMHPHHQETLKKNRVMLAKQLLLSEL-----------LEHLLEKDIITLEM- ------------------------------------------------------------ -----RELIQA--------KVGSFSQNVELLNLLPKR-PQAFDAFCEALR--ETKQGHLE DIELKLR----------------------------------------------------- -----------------------------------------------------------V S--ALMK--PTG-----------------LGSDYNDILGLM-VKLNT------------- VFWFSVYT-----TDTVEHSLDNKDGPVCLQVKPCTPEF----YQTHFQLAYRL---QS- RPRGLALVLSNVHFT-------GEKELEFRSGGDVDHSTLVTLFKLLGYDVH-VLRDQTA QEMQEKLQNFARLPA--HRVTDSCIVALLSHGV-E-------GAIYGVD----------- --GKLLQLQEVFRLFDNANCPSLQNKPKMFFIQACRG-------------DETDRGV-DQ ---QDGKNHAGSPGCEESDAGK--------------EKLPKMRLPTRSDMIC---GYACL KG--TAAMRNTKRGSWYIEALAQVFSE-------RA-CDMHVA--DMLVKVNALIKDREG Y--APGTEFHRCKEMSEYCS-----TLCRHLYLFPGHPPT------------- >B_taurus_ENSBTAP00000024166 --------------------------------------MAAPSAGFQYPLQPKEQMAADR GRRMLRGCGMHPDHQEALKKNRVVLAKELLLSEL-----------LEHLLEKDIITLEM- ------------------------------------------------------------ -----REHIQA--------KTGSFGQNVELLNLLPKRGPQAFDAFCVALR--ETKQSHLE ELLLRTL----------------------------------------------------- -----------------------------------------------------------S G--LQPV--VPP-----------------LSCDYDLSLPFP-VCESCT------------ RHKRLHLS-----PDAVEHSLDHGDGPPCLQVKPCTPEF----YQTHHHLAYRL---QS- RPRGLALVLSNVHFT-------GEKDLEFRSGGDVDHSTLVTLFKLLGYKVH-VLLDQTA QEMQEKLQNFAQLPV--HRVTDSCIVALLSHGV-E-------GGVYGVD----------- --GKLLQLQEVFRLFDNANCPSLQNKPKMFFIQACRG-------------DETDRGV-DL ---QDGKNHDRSPKCEESDASR--------------EELLKMRLPTRSDMIC---GYACL RG--TAAMRNTKRGSWYVEALTQVFSE-------RA-CDMHVA--DMLVKVNALIKEREG Y--APGTEFHRCKEMSEYCS-----TLCRHLYLFPGHPPT------------- >M_musculus_ENSMUSP00000031895 --------------------------------------MAAPSGRSQSSLHRKGLMAADR RSRILAVCGMHPDHQETLKKNRVVLAKQLLLSEL-----------LEHLLEKDIITLEM- ------------------------------------------------------------ -----RELIQA--------KGGSFSQNVELLNLLPKRGPQAFDAFCEALR--ETRQGHLE DLLLTTL----------------------------------------------------- -----------------------------------------------------------S D--IQHV--LPP-----------------LSCDYDTSLPFS-VCESCP------------ PHKQLRLS-----TDATEHSLDNGDGPPCLLVKPCTPEF----YQAHYQLAYRL---QS- QPRGLALVLSNVHFT-------GEKDLEFRSGGDVDHTTLVTLFKLLGYNVH-VLHDQTA QEMQEKLQNFAQLPA--HRVTDSCVVALLSHGV-E-------GGIYGVD----------- --GKLLQLQEVFRLFDNANCPSLQNKPKMFFIQACRG-------------DETDRGV-DQ ---QDGKNHTQSPGCEESDAGK--------------EELMKMRLPTRSDMIC---GYACL KG--NAAMRNTKRGSWYIEALTQVFSE-------RA-CDMHVA--DMLVKVNALIKEREG Y--APGTEFHRCKEMSEYCS-----TLCQQLYLFPGYPPT------------- >R_norvegicus_ENSRNOP00000022672 --------------------------------------MAASSGRSQSSLHRKGLMAADR RSRILAVCGMHPDHQETLKKNRVVLAKQLLLSEL-----------LEHLLEKDIITLEM- ------------------------------------------------------------ -----RELIQA--------KGGSFSQNVELLNLLPKRGPQAFDAFCEALR--ETRQGHLE DLLLTTL----------------------------------------------------- -----------------------------------------------------------S D--IQHI--LPP-----------------LSCDYDSSLPFS-VCESCP------------ PHKQSRLS-----TDTMEHSLDNGDGPPCLQVKPCTPEF----YQAHYQLAYRL---QS- QPRGLALVMSNVHFT-------GEKDLEFRSGGDVDHTTLVTLFKLLGYNVH-VLYDQTA QEMQEKLQNFAQLPA--HRVTDSCIVALLSHGV-E-------GGIYGVD----------- --GKLLQLQEVFRLFDNANCPSLQNKPKMFFIQACRG-------------DETDRGV-DQ ---QDGKNHAQSPGCEESDAGK--------------EELMKMRLPTRSDMIC---GYACL KG--NAAMRNTKRGSWYIEALTQVFSE-------RA-CDMHVA--DMLVKVNALIKEREG Y--APGTEFHRCKEMSEYCS-----TLCQQLYLFPGYPPT------------- >P_pygmaeus_ENSPPYP00000020323 --------------------------------------MAAPTAGSWSTFEHKELMAADR GRRILGVCGMHPHHQETLKKNRVVLAKQLLLSEL-----------LEHLLEKDIITLEM- ------------------------------------------------------------ -----RELIQA--------KVGSFSQNVELLNLLPKRGPQAFDAFCEALR--ETKQGHLE DMLLTTL----------------------------------------------------- -----------------------------------------------------------S G--LQHV--LPP-----------------LSCDYDLSLPFP-VCESCP------------ LYKKLRLS-----TDTVEHSLDNKDGPVCLQVKPCTPEF----YQTHFQLAYRL---QS- RPRGLALVLSNVHFT-------GEKELEFRSGGDVDHSTLVTLFKLLDYDVH-VLCDQTA QEMQEKLQNFAQLPA--HRVTDSCIVALLSHGV-E-------GAIYGVD----------- --GKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRG-------------DETDRGV-DQ ---QDGKNHAGSPGCEESDAGK--------------EKLPKMRLPTRSDMIC---GYACL KG--TAAMRNTKRGSWYIEALAQVFSE-------RA-CDMHVA--DMLVKVNALIKDREG Y--APGTEFHRCKEMSEYCS-----TLCRHLYLFPGHPPT------------- >M_domestica_ENSMODP00000001598 ------------------------------------------------------------ --RMLGVWGMEQEHQEALKKNRVVLAKQLLLSEL-----------LEHLLEKDIITLEM- ------------------------------------------------------------ -----RELIQA--------KVGSFSQNVEFLNLLPKRGPHAFEAFCDALR--ETKQGHLE DLLHRTL----------------------------------------------------- -----------------------------------------------------------Y S--FQNL--RPP-----------------LGCDYDSSFPLP-VCDSCP------------ PHKQLRLS-----VETMEHSLDNGDGPPSLQVKPCTPEF----YQTHQHLAYRL---QS- RPRGLAMVLSNVHFN-------GEKDLEFRSGGDVDHSSLVTLFKLLDYDVH-VLRDQTA QKMQENLQRFAQLSA--HQSTDSCMVALLSHGI-E-------GGIYGVD----------- --GKLLQLQEVFRLFDNANCPNLQNKPKMFFIQACRG-------------DETDRGV-DL ---RDGKEHVASPGCEESDAGK--------------EKILKMRLPTRSDMIC---GYACL KG--TAAMRNTKRGSWYIEALTQVFSE-------RA-RDMHVA--DML--VNALIKDREG Y--APGTEFHRSKEMSEYSS-----TLCRHLYLFPGHPPT------------- >C_familiaris_ENSCAFP00000005409 --------------------------------------MAAASAGRPAALQRKAPTAAGR GRRILGVCGMHPDHQEALKKNRVVLAKQLLLSEL-----------LEHLLEKDIITLEM- ------------------------------------------------------------ -----REHIQA--------KVGGFSQNVELLNLLPKRGPQAFDAFCVALR--ETKQGHLE DLLLTTL----------------------------------------------------- -----------------------------------------------------------S G--LQHG--LPP-----------------LSCDYDLSLTFP-MCESCP------------ PQKQLRLS-----PDTVEHSLDNGDGPPCLQVKPCTPEF----YQTHYQLAYRL---QS- RPRGLALVLSNVHFT-------GEKDLEFRSGGDVDHSTLVTLFKLLGYKVH-VLLDQTA QEMKEKLQNFAQLPA--HRVTDSCIVALLSHGV-E-------GGIYGVD----------- --GKLLQLQEVFRLFDNASCPNLQNKPKMFFIQACRG-------------DETDRGV-DQ ---QDGKNHTGSSECEESDASK--------------EELLKTRLPTRSDMIC---GYACL RG--TAAMRNTKRGSWYIEALTQVFSE-------RA-CDTHVA--DMLVKVNALIKEREG Y--APGTEFHRCKEMSEYCS-----TLCRHLYLFPGHPPT------------- >T_guttata_ENSTGUP00000013612 ------------------------------------------------------------ ---MLAACGMQRCHQEALKKNRVMLAKQLVLNVL-----------VEHMVEKDIIPTEM- ------------------------------------------------------------ -----VEMIQA--------KSGSFDRNVEFLNLLPKRGPNAFSAFCEALR--ETQQQHLE TLILKTM----------------------------------------------------- -----------------------------------------------------------S S--LSQE--IAR-----------------LEHCHESDLPYP-ASESCN------------ SKRPRWL-------EPMEHSLDNRDGPSIPPVKYCTPEF----YHNHQHLAYKL---TS- EPRGLALILSNVRFS-------SEKDLEYRAGGDVDCASLEMLFRHLGYRVT-VFCDQTA QDMQNALERFSKLQD--HRDVDSCIIALLSHGV-E-------GGVYGSD----------- --GKLLELQETFRLFDNANCPNLQNKPKMFFIQACRG-------------DELDRGV-DQ ---RDGKGRSDSPGCEESDANK--------------EESLKLRLPTCSDMIC---GYACL KG--TAAMRNTKRGSWYVEALTSVFAE-------DS-QHTHVA--DMLVKVNRQIKQREG Y--APGTEYHRCKEMSEYCS-----TLCRDLYLFPGYLPGK------------ >D_rerio_ENSDARP00000075318 ------------------------------------------------------------ ---------MADQLLENLRPDLIKGLSERVINGL-----------LDDLQQKKVFGEEE- ------------------------------------------------------------ -----IEDIQH-------RMKTRADQARHVIDDVKRKGVKASEIMLASLK---TRDPHLY DTLGIE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RLLVPVPETELTPSQLSETTGCST----DKTNTMNEYEM---KS- NPRGLCLIFNNENFK---------DPDMKRHGSQMDTASLKDLFEWLGFSVE-IKQDQTV SAMKRTLKEYSE--D--RKHGDCFVCCVLSHGN-E-------SGVLGSD----------- --EKICPVDDITSPFNGANCSSLAGKPKVFFIQACRG-------------HEIQSKV-MV ---ADGSGGSRT----------------------QKPGRVSVSIPKDSDFLI---ARSTV EG--YVSIRDRTSGTWFIQSLCENLKE-------GSKRGHDIL--MILTKVNNDVSRKEG S-LKVKNEIVDAKVTPQPIF-----TLRKLLIFRPLKKTGRFS---------- >A_carolinensis_ENSACAP00000006831 ------------------------------------------------------------ -SRMLGVCGMQKCHQEALKKNRVSLAKQLVLKEL-----------MEHLIEKDVITEEM- ------------------------------------------------------------ -----MEMIQA--------KAGNFSQNIEFLNLLPKRGPKAFSAFCEALR--ETKQPHLE EMLLLNL----------------------------------------------------- -----------------------------------------------------------I DFLLFHHVIVPP---------------------QNAHLPLHTVCDLLP------------ FAYQLFIS----SAEPMEHSLDDGDGPHYPQVMPCTPEF----YRTHEQLAYKL---KS- QPRGLALILSNIHFN-------KETDLDFRSGGDVDNTALHMLFKHLGYQVV-VRQDRTA QEMKEELEIFSKHPA--HRNVDSCIVSLLSHGI-E-------GGIYGID----------- --GKLLQLQEIFRLFDNANCPNLQNKPKMFFVQACRG-------------DETDHGV-DQ ---IDGNDRASSPGCEETDANK--------------KENPKLRLPTCSDMIC---GYACL KG--TAAMRNTKHGSWYVEALTSVFAE-------DS-GHMHVA--DMLVKVNRLIKLREG H--APGTEFHRCKEMSEYCS-----TLCQDLYLFPGYFPG------------- >D_rerio_ENSDARP00000083664 ------------------------------------------------------------ ---MLGECGMTKWERLALRRNSVKMLQDLVVDDLL----------IQCLQQDGILTDSM- ------------------------------------------------------------ -----AESIMA--------KPTSQGRSHQLLFLLPKRGPRAFSTFCSALK--ETEQHHLC KLLMDFT----------------------------------------------------- ------------------------------------------------------------ ------------EKDKKN----SQYKL---------------SPEICK------------ KKNKHTHT-----HKSMEMCLD-ADSPVTTAVLPCTPEF----YQSHRPQAYPM---RS- CPRGLALVLSNVRFD------SANTDLDIRRGGEVDEETLRRLFTELDFKVS-LHRDLTA EAMRRCLEQFAQQQE--HAAYDCAVVCLLSHGV-E-------GSVYGTD----------- --GQLLELDWVFEVFDNARCPLLQNKPKMFFIQACRG-------------EEMDNGV-DQ ---LDGQERTQSPGCEQRDAGREGERDNREKKEEKERERLRVKLPQRSDMIC---GFATL KG--TAAMRNTKKGSWFIQELNTAIRQ-------RA-NNTHLS--DILVQVNGQIKSREG Y--APGSAHHRCKEMSEFTS-----SLCKDLYLFPKYYPSN------------ >T_rubripes_ENSTRUP00000037606 ------------------------------------------------------------ -RSKMLHCGMREQDARTLRRQSAVLCKQLVVDELL----------IQCLQADDILTESM- ------------------------------------------------------------ -----AESIMA--------EQTSQKRSWRLQLLLPKRGPKAFSSFCSALR--ATDQQHLC DLLTQTF----------------------------------------------------- ------------------------------------------------------------ ------------ETNGNG---------THVETCVDSSVPLP-TQEAVP------------ GVCVCVCE-----TESLEVSLD-ADSPINTPVLPCTPDF----YLSHFQQSYKM---AS- SPRGFALVISNVTFN-----PCAAPELDPRKGGEVDDEVLRKVFTELEYSVT-VQRDLTA QGIKTCIQNFSGRPE--HRSVDSCVVCLLSHGV-E-------GAVYGID----------- --GELLQLDWVFEAFDNAHCPLLQNKPKMFFIQACRG-------------DEMDCGV-EQ ---IDGPSRTSSPSCEQRDAGREG--------------RPRIKLPQRSDMIC---GFASL KGQDSSHAEHQKRGSWFIQELNTALRL-------HA-RDRHLA--DILVQVNRRIKDREG Y--APGTAHHRCKEMSEFTS-----SLCKDLFLFPKYQPQ------------- >C_elegans_C48D1.2 ------------------------------------------------------------ --------MMRQDRRSLLERNIMMFSSHLKVDEI-----------LEVLIAKQVLNSDN- ------------------------------------------------------------ -----GDMINS--------CGTVREKRREIVKAVQRRGDVAFDAFYDALR--STGHEGLA EVLEPLA-----RSVDSNAVEFECPMS--------------------------------- --------------------PASHRRSRALSPAGYTSPTRVHRDSVSSVSSF--TSYQDI YSRARSRSRSRALHSSDRHNYSSPPVNAFPSQPSSANSSFTGCSSLGY------------ SSSRNRSF------SKASGPTQYIFHEEDMNFVDAPTIS----RVFDEKTMYRN---FS- SPRGMCLIINNEHFE----------QMPTRNGTKADKDNLTNLFRCMGYTVI-CKDNLTG RGMLLTIRDFAKHES----HGDSAILVILSHGE-E-------NVIIGVD----------- --DIPISTHEIYDLLNAANAPRLANKPKIVFVQACRG-------------ERRDNGF-PV LDSVDGVPAFLRRGWDNRDGPLFNFLGC----VRPQVQQVWRKKPSQADILI---AYATT AQ--YVSWRNSARGSWFIQAVCEVFST-------HA-KDMDVV--ELLTEVNKKVACGFQ T----SQGSNILKQMPEMTS-----RLLKKFYFWPEARNSAV----------- >T_nigroviridis_ENSTNIP00000010874 ------------------------------------------------------------ ----MLQCGMVERDAQALKKQSAVLFKQLVVDELL----------IQFLQADDILTDSM- ------------------------------------------------------------ -----AESILA--------EQTSHKRCWKLLHLLPKRGPKAFSSFCSALR--ETDQKHLC DLLARTS----------------------------------------------------- ------------------------------------------------------------ ------------QENGNG---------THLETCVDSSVPLP-TQEAVP------------ AKRART-------QESMEISLD-ADSPINTPVCPCTPDF----YHSHSQQSYKM---TS- SPRGLALVISNVRFS-----PFAAPDLDPRQGGEVDDEVLRKVFTELDYLVT-VQRDLTA QGIKTCIENFSRRPE--HQSVDSCVVCLLSHGV-E-------GAVYGVD----------- --GKLLQLDWVFTAFDNAHCPLLQNKPKMFFIQACRG----------GSVDEMDCGV-EQ ---IDGPSRTGSPSCEQRDAGREGE-------------RPRIKLPQRSDMILRSPRSKSP SG--TAAMRNTKRGSWFIQELNKALRL-------HA-RDKHLCRHSGAGKVNSRIKEREG H--APGTAHHRCKEMSEYTS-----SLCKDLFLFPKYQPQY------------ >O_latipes_ENSORLP00000015114 ------------------------------------------------------------ -RSVTQKCGMQKRDAEALRNCSVCLLKDLVVDELL----------IQALVKDGILTQNM- ------------------------------------------------------------ -----AESIMV--------QKTSHHRSFKLLLLLPKRGPRAFKSFCSALK--ETEQEHLC DLLTQ------------------------------------------------------- ------------------------------------------------------------ ------------EEEGREVCLDTPLINSEEQSEVSSSMSYP-IHDSEG------------ LQLEMRTN-----TESMESSLD-ADSPINTPVLACSADF----YLSHCQQSYRM---NS- SPRGSVLVISNINFD-----PRAAPELDPRKGGEVDDEVLRKLFTELDYSVN-FHRDLTA QDMKMVIENFCRRPD--HQKVDSCVVCLLSHGV-D-------GAIYGTD----------- --GQQLALDWVFEAFDNAHCPLLQNKPKMFFIQACRG-------------DEMDCGV-EQ ---IDGPARTFSPTCEQRDAGREEQGD-ADGRQRASTGRQRIKLPQRSDMIC---GFASL KG--TAAMRNTKKGSWFIQELNTALRL-------NA-RDTHLA--DILVQVNKRIKEREG Y--APGTAHHRCKEMSEFTS-----SLCKDLYLFPKYQPQC------------ >O_anatinus_ENSOANP00000005545 ------------------------------------------------------------ ---------MQPCHQEALKKNRVALAKQLMLSEL-----------LEHLLEKDVITMEM- ------------------------------------------------------------ -----RELIQA--------KAGSFSQNVEFLNLLPKRGPKAFDAFCAALR--ETKQGHLQ DLLYRTL----------------------------------------------------- -----------------------------------------------------------S N--LS-----PPSTAVGALGTQGEELAGRLGGRWRGLPSLP-SVSVCPVVVCPFLMVLGN SRLQPALSVGDLLPEEMEHSLDNGDGPPCPQVKPCTPEF----YRVHHHLAYRL---ES- RPRGLALVLSNMRFN-------GEKDLEFRSGGDVDHNALITLFKHLDYSVE-FLRDQTA QEMQEKLHNFAQSPR--HRFTDSCVVALLSHGV-E-------GGIYGVD----------- --GKLLQLQEVFRLFDNANCPSLQNKPKMFFIQACRG-------------DETDRGV-DQ ---RDGKERAASPGCEESDAGK--------------EEMLKVRLPTRSDMIC---GYACL KG--TAAMRNTKRGSWYIEALTQVFAE-------SA-RDMHVA--DMLVKVS-------- ----------------------------------------------------- >G_aculeatus_ENSGACP00000013740 ------------------------------------------------------------ -------CGMQERDRLALRTRSTVLCKQLVVDELL----------IQSLQTDEILTEAM- ------------------------------------------------------------ -----AENIMA--------EQTSQKRSWRLLLLLPKRGPRAFSSFCSALQ--ETEQQHLY ELLIQSS----------------------------------------------------- ------------------------------------------------------------ ------------EKDGKE----TPGMLMCGQF-IDSSLPLP-TQEVVA------------ AKRART-Q-----AESMEFSLD-ADSPINSPVLPCTPDF----YLSHCHQSYRM---NS- SPRGFALVISNVTFD-----PCAAPDLDPRKGGEVDDEVLRKVFTELDYVVK-VHRDLTA QDMRTCIEEFSRRPD--HRTMASCVVCLLSHGV-E-------GAIYGTD----------- --GQLLKLDWVFESFDNAHCPLLQNKPKMFFIQACRG-------------EEMDCGV-EQ ---IDGPVRTCSPSCEQRDAGREGQGD-ASARQRGD--MGRIKLPQRSDMIC---GFASL KG--TAAMRNTKRGSWFVQELNKRLRL-------HA-RDTHLA--DIMVQVNRHIKEREG Y--APGTAHHRCKEMSEFTS-----SLCKDLYLFPKYQPQ------------- >O_cuniculus_ENSOCUP00000001859 --------------------------------------MAAPSAGSRASLQQKGLLAADR GRRITAVCGMHPDHQETLKKNRVVLAKQLLLSEL-----------LEHLLEKDIITLEM- ------------------------------------------------------------ -----RELIQA--------RVGSFSQNVELLNLLPKRGPQAFDAFCVALR--ETKQGHLE DLLLTTL----------------------------------------------------- -----------------------------------------------------------S G--LQHV--LPP-----------------LSCDYDLSLPFP-VCESCS------------ PHKQPRLS-----TETEERSLDNGDGPPCLQVKPCTPEF----YQTHYQLAYRL---QS- RPRGLALVLSNVRFT-------GEKDLEFRSGGDVDHSTLIALFKLLGYNVH-VLHDQTA QEMREKLQNFAQLPA--HRVMDSCIVALLSHGV-E-------GGIYGVD----------- --GKLLELQEVFRLFDNANCPSLQNKPKMFFIQACRG-------------DETDRGV-DQ ---QDGKNQAGSPGCEESDAGK--------------EP-LKMRLPTRSDMIC---GYACL K----------------------------------------------------------- ----------------------------------------------------- >G_gallus_ENSGALP00000002083 ------------------------------------------------------------ ---------MEEAQRSALRRGRVRLVEGLRPEVL-----------WGPLQARGVFTSAM- ------------------------------------------------------------ -----VEDMQS--------TGTRREQARQLVIDLETRGKQAFPIFLSILR--DTGHGDLA DMLDEGC-----GSPMSPPVDL-------------------------------------- ---------------------------------------------RPVQLEL--PGERRD KSVSTA------------------------------------------------------ ----------------ERLSIPVQPESERFRMPPAPAQACPTGLAGECSEVYQL---RA- DPCGHCLIFNNVSFS-------RDSDLSTRAGSDIDCEKLEKRFRSLCFHVR-TLRNLKA QEIDVELRKLAR-LD--HSALDCCLVVILSHGC-QTSHIQFPGGIYGTD----------- --GKIIPIERIVNYFNGSQCPSLRGKPKLFFIQACGG-------------EQKDQGF-EV ---DCESPQDETCRRSIESDAIPFQAPSGNE----DEPDAVASLPTPGDILV---SYSTF PG--FVSWRDKVSGSWYVETLDSVLEH-------YA-RSEDLL--TMLLRVSDIVSTK-- ---------GRYKQIPGCFN-----FLRKKFFFLCK----------------- >B_taurus_ENSBTAP00000003205 ------------------------------------------------------------ ---------MNEADRLLLRRYRVRLVGELQVASL-----------WDALLSRELFTPDM- ------------------------------------------------------------ -----IEDIQR------AGSGSRRDQARQLILDLETRGSQALPLFISCLE--DTGQDTLA SLLKTSR-----QAAKQ------------------------------------------- ------------------------------------------------------------ ----------------SKPSQGKLAPVVLGPEELWPAKLRPEV----------------- --------------LRPEVPRAVDAGSGGFTDVCP-QDR----AKGNADLAYVL---NA- DPCGHCLIINNVNFC-------RESGLRARTGSNIDCERMRQRFHLLQFVVE-VKCDLTA KQMVQALMQLAR-QD--HSALDCCVVVILSHGC-QASHLQFPGAVYGTD----------- --GCPVSVERIVNTFNGTGCPSLRGKPKLFFIQACGG-------------EQKDHGF-EV ---ESTSPEDKTPSSDPEADATPFQEGPRSI----DEPDAVSSLPTPSDILV---SYSTF PG--FVSWRDPKSGSWYIETLDSIFEQ-------WA-HCEDLQ--TLLLRVANAVSVK-- ---------GIYKQMPGCFN-----FLRKKLFFKT------------------ >T_guttata_ENSTGUP00000006879 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------MTDIGDGAHLGKDLADTKSIPGFK---GKNL---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PASKSMD----SGILPDYSYRM---DY- PEMGECIIINNKNFH-------RYTGMSPRSGTDADAASVREVFMKLGYKIK-INNDLSC EGIFNLLKNVSE-ED--HSKRSSFVCVLLSHGD-E-------GLIYGTD----------- --G-PLELKALTSLFRGDRCRSLAGKPKFFFIQACRG-------------TELDSGI-ET ---DSGS-----------------------------EETMCQKIPVEADFLY---AYSTA PG--YYSWRNSAEGSWFIQSLCKMLKE-------HA-RKLELM--QILTRVNRRVA-EYE S-CSTRQDFNAKKQIPCIVS-----MLTKEFYFPS------------------ >G_gorilla_ENSGGOP00000011776 ------------------------------------------------------------ --------MADEKPSNGVPVHMVKLLIKTFLDG--I---------FDDLMENNVLNTDE- -------------------------------------------------I---------- -------HLIG------KCLKFVLSNAENLVDDITETAQIAGKIFREHLW--NSKKQLSS ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------DISSD-GER-- EANTSGLNICNKEFN----------YLHNRNGSELDLLGMRDLLENLGYSVV-IKENLTA QXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXX-X-------XXXXXXXXXX-------- XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-------------XGAGIVWFTT ---DSGKASADTHGRLL---------------QGNICNDAVTKAHVEKDFIA---FKSST PX--XXXXXXXXXXXXXXXXXXXXXXX-------XX-XXXXXX--XXXXXVQHSFETPNV L-----------TQLPTIERL----SMTRYFYLFPGN---------------- >C_elegans_Y48E1B.13a ------------------------------------------------------------ ----MVLKTIEDNCKSQFDDDLVEDFNNFQTTSSMS---------SSTTISTEDFNTIE- -------------------------------------------------IESTFEICRSG SYTEEPILGENDEFLIDFEMERFLKFLKDKTKQVEKRKEPFSQKEIYAVFQRRIKSELCI ETVKKKF-----QPLLPNAIQTCEFDEETMI----------------------------- ------RMIYGAGIRIDSVDFWNRFTSKATISLDCYSRLISYSSDSLTLSGT--HRSGFT YHWISTPPVTYHRTENKDPNIQEPSPVEFLDVQSSLGSSMKPPILDKP------------ TKLDDPAE------TRHDCSYSLEEYDSQSRMPRTDAKK----SNHKHKYCYEM---NS- NPRGTVLILSNENFK----------NMERRVGTKQDEVNLTKLFQKLQYTVI-CKRNLEA ESMLEAIKEFAE-----MAHTDSIILFLLSHGDGA-------GSVFGID----------- --DMPVNVMEVSTYL--AYHQNLLLKPKWVAVSACRG-------------GKLNMGV-PV ---DGLPALEDKCAPIS-----------KFWNLMMSRIMPGTFTSLNADVII---SFSTT DG--FTSYRDEEAGTWYIKSMCKVFNK-------HS-KTMHLL--DILTETGRNVVTKYE N----VQGNVVLKQAPEILS-----RLTKQWHFSRSM---------------- >O_anatinus_ENSOANP00000015596 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------AGTRRDQARQLVTDLETRGRRALSVFISCLR--ETDQHALA ALLSEGC-----QAPQVTPVDI-------------------------------------- ---------------------------------------------RPVEIIR--PGGQGD VCKYSK-----IHPKCYSPPLPFQSTSPLRGKEQWTGSVKPFV----------------- ---------------------PVPSTTKREQEATR-PGE----KQGMAIKVYSL---KS- EPCGHCLIINNVDFS-------LGSGLSTRTGSDVDCEKMKRRFRLLHFEVA-VERNLTA EEMVKALNKLAK-KD--HSALDCCVVVILSHGY-QASHIQFPGGIHGTD----------- --GESISVETIVNYFNGSRCPSLGGKPKLFFIQACGG-------------EKKDPGF-EV ---NLDSPEDHPTGSDPESDAAPFQAAPEDY----DEPDAVASLPTPSDILV---SYSTF PG--FVSWRDTQSGSWYIETLDSVLDQ-------WA-HTEDLL--TLLLRVSNGVSSK-- ---------GKYKQIPGCFN-----FLRKRLFFNTK----------------- >R_norvegicus_ENSRNOP00000017972 ------------------------------------------------------------ ---------MEEADRQLLRRCRVRLVRELQVAEL-----------WDALLSRELFTRDM- ------------------------------------------------------------ -----IEDIQR------AGSGSRRDQARQLVIDLETRGRQALPRFISCLE--DTGQGSLA SFLQSSG-----QAAKQDPEAV-------------------------------------- ---------------------------------------------TPLDHLV--PVVLGP MGLKSKEQKV-VKLDPSQPALGNLTPVVLGPEELWPTRLRPEV----------------- --------------LTPETPRPVDIGSGRAHDVCT-PGK----IERHADMAYTL---DS- DPCGHCLIINNVNFC-------PSSGLSTRIGSHVDCEKLQHRFCWLRFMVE-VKNDLTA KKMVTALMEMAH-RD--HRALDCFVVVILSHGC-QASHLQFPGAVYGTD----------- --GCSVSIERIVNIFNGTGCPSLGGKPKLFFIQACGG-------------EQKDHGF-EV ---AFTSSQDKAFDSDSEPDAVPYQEGPRTL----DQLDAVSSLPTPSDILV---SYSTF PG--FVSWRDKKSGSWYIETLDGVLEQ-------WA-RSEDLQ--SLLLRVANAVSEK-- ---------GVYKQIPGCFN-----FLRKKLFFKLH----------------- >T_guttata_ENSTGUP00000017449 ------------------------------------------------------------ ---------MEERQRRALRRGRARLVAALRVEPL-----------WEPLEQRGLFTRPM- ------------------------------------------------------------ -----LEELQS--------AGSRGEQARQLIIDLETRGKQAFPAFLSILR--DTGQGHLA EMLMQEC-----ESRPVPPQLP-------------------------------------- -------------------------------------------DLRPVELELQEANQRCA VVLQTA------------------------------------------------------ ---------------------ARDVAAGIPLTVGKSPE-----VMSFIILDYEM---KA- DPCGHCLILNNVNFC-------RDSGLSTREGSDIDCEKLERRFKALCFTVL-TRRDLKA QEMVLELLKLSR-QD--HSALDCCIVVILSHGC-QTSHIQFPGGVYGTD----------- --GKPIPIEKIVNYFNGSSCPSLRGKPKLFFIQACGG-------------EQRDQGF-VV ---DCDSPKEEALGDSLESDAIPFRVPSDNV----DEPDAIASLPTPSDILV---SYSTF PG--FVSWREKSSGSWYVETLDSVLEQ-------YA-HSEDLL--SMLVRVAHAVSAR-- ---------GRYKQIPGCFN-----FLRKKFFFVCR----------------- >C_intestinalis_ENSCINP00000002956 ------------------------------------------------------------ --------AMKKRHRNTLIKNRVKLAKCLHLDEV-----------LQYLVQCGILTDVT- ------------------------------------------------------------ -----VERITS--------KPTRFSQNVAFLTCLPTRGPRAYGTFLEALR--ISSQEHLV DILEKVD----------------------------------------------------- ------------------------------------------------------------ -ISNAIPNNKPITPTTLHATITSNVHSEFVCARRQPMEI--------------------- --------------GKCEDKNDAKDGHNRLRVQNSTVAF----FNETYNSGYKM---TT- KSRGYALIVCIGRFN-------AGVRLPDRQGTDADKKNLLAIFEQINYKTI-LVENCNK FEMERRVKQFAQMEE--HRKCDSCAVAILSHGS-K-------TDIYASD----------- --GRSIPIESLIKMFDNVNCPPLRNKPKIFFIQCCRG-------------NNMDQGI-DA ---TDGPPTLNSETSDS-------------------YNSTTHNITTDVDIIS-----TAS KR--NAALRNTRHGSWYIQVLVKTIAQ-------HA-HEMDLL--EILTLVNSAIKSKEG H--STDFDSQGVKEMSEFHS-----TLCKKLFFYPGIVQTE------------ >M_domestica_ENSMODP00000004412 ------------------------------------------------------------ ---------MEESQRELFQKNRLRLVCELQVEPL-----------WDLMLDRELFTRDM- ------------------------------------------------------------ -----IEDIQR--------AGTRRDQARQLVTDLQTRGKRALPIFISCLE--ATGQWDLA ALLSESN-----TTLTQQPDPI-------------------------------------- -------------------------------------------DIKPVEMIR--SGGLRS TGRYTSMVSLHLLLLANSPFLYFIDAVLVSAHNLFPLELIK------------------- --------------RQPTFSKVLSLLYKLRFPFC---------PPPQVGQVYTL---NS- DPCGYCLIINNVDFC-------ASSGLSSRKGSNIDCEKMHNRFQALHFAVE-VERNLSA KGMGAALQQLAE-RD--HSALDCCVVVILSHGC-QASHIQFPGAIHGTD----------- --GASISVERIVNIFSGSRCPSLGGKPKLFFIQACGG-------------DQRDHGF-QV ---SSNIPEDKSPGSDPETDATPFQNNF-------DQPDAVASLPTPSDILV---SYSTF PG--FVSWRDPKSGSWYIETLDRVLEE-------WA-DREDLL--HMLLMVSNAVSAR-- ---------GTYKQIPGCFN-----FLRKRFFFKTK----------------- >D_rerio_ENSDARP00000047019 ------------------------------------------------------------ ---------MEQKHRQILQRHRLNLVKALNPEDV-----------CDKLLSKGVFTQDM- ------------------------------------------------------------ -----IDEIQS--------KATRRDQARQLVKDLETRGSLAFPAFLDSLR--ETGHNDLA ELLQSGDGVHRPPVISVQPSPI-------------------------------------- ------------------------------------------------------------ ---PLPVQNLNHTEKPDKPDIASPRLVPLR------------------------------ ----------------PESLPVHKTYSPPSETVVR-PTR----PRRDSIQCYKM---DA- SPCGVCLIINNINFE-------KASELNDRKGSNIDCDKLEKRFKALNFEVT-VKRNLKS KRIRHEMASLAK-KD--HSTYDCCVVIILSHGT-EASHNRFPGAVHGVD----------- --GPAVPIQIITNYLNGQNCPSLQGKPKLFFIQACGG-------------GEKDIGF-EV ---SPDDVQPSIGGIDDEMDAIPMSSSSDSLSTASDELDARASLPTPSDILV---SYSTF PG--YVSWRDTEAGSWYVENLDRVLEE-------NA-ITDDLV--TMLMLVNDAVSQISA K--------GLYKQMPGSFN-----FLRKLLYFQSSQS--------------- >T_guttata_ENSTGUP00000004278 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------MSGSERRPPAGHVQLDSRPTLPTT-DGNE---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NITEVDALNIRQ-----SLDPAEEYKM---NH- QRRGLALIFNHERFY-------WHLRLQDRRGTWVDRNNLKSILTELGFEVR-LFDDLKK EDVQQRIYEAST-AD--HSNADCFVCVFLSHGE-D-------GHIFAYD----------- ---DKIEIQTITDMFRGDKCQSLVGKPKIFIIQACRG-------------DKHDDAV-IA ---HDSADG-SESPGNE----------------TDVDAAGVYTLPAGADFIM---CYSVA QG--YYSHRDTINGSWYIQDLCETLRK-------HG-SSLEFA--ELLTVVNRKVSCRRV G-MCKDINAIGKKQIPCFAS-----MLTKKLYFHPKSK--------------- >M_domestica_ENSMODP00000036247 ---------------------MDFHTFLYGIAEEIDSADLASLKFLCLDQIPLKKQQHIK DALVLFQTLEERGLLEEDNLFFLKELLFRINRIDLL---------NEPLNTKGPEMEREL QVPNKARISPYRLHLHTTIWPFRDNWTCRITLSVSFTSRTKQLLSVMVILLFNLSEGVGP SELKSIKFMLS--SKIPKCKIEDDMTLMDLFIEMEKRGILGEGNLDALKIVCDQIDKSLL KKIQEYE-----ISKGRNNLFL-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------IYQNTQPQEVYD----SAGEKGNVYKM---SS- RPRGYCLIINNFDFKISRKERPENHYLTDRRGTNKDEEALKNIFKELHFDIQ-SFQDLTA EGIQQVLKTFKD-NN--HESKDCFVCCLLSHGN-K-------GTIYGID----------- --GKEVPIRDLTSYFSGSNCPSLAGKPKVFFIQACQG-------------KATQYGI-SL ---DTDSEQQRE-------------------SLEADKSFQSECIPNEADFLL---GMATV EN--YVSYRDSARGTWYIQSLCKNLKE-------GCLRGNDIL--TILTEVNSEVSQKTD P-------KNNGKQMPQPKI-----TLRKKLVFPIS----------------- >M_domestica_ENSMODP00000005560 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MEDTGTTVDAKSIKNSG---VKSL---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HSSKSVE----SGLS-SDSYKM---DY- PEMGLCVIINNTHFH-------NDTELSPRTGSDKDAANLIDIFRSLKYEVR-NKNNLTR DKMIELLRQVSE-ED--HSQRSSFVCVILSHGE-E-------GVIFGTD----------- --D-SVELKELTYFFKGYKCKSLTGKPKLFIIQACQG-------------REFDCGV-ET ---DSGTD----------------------------EDVACHKIPVEADFLY---AYSTV PG--YYSLRDPKDGSWFIQALCAVLKQ-------HA-HKLEIM--QILTRVNRKVATEFE S-YSSKASLHAKKQMPCIMS-----MLTKELYFSH------------------ >O_anatinus_ENSOANP00000000517 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------AASGEVMVDSKSFHSSQGYSSRKV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PGKQFLG----SSASLDDRYRM---DY- PNMGICLIINNKNFH-------PDTRMGCRSGTDVDAASLRDTFKKLKYEVR-CKNDLKR REILELLTSVAH-ED--HSKRSSFVCVLLSHGE-E-------GVIFGTD----------- --G-SLELKSLASLFRGDNCRSLVGKPKLFIVQACRG-------------TELDSGV-EA ---DSSSA----------------------------DDGSEQKIPVEADFLY---AYSTA PG--YYSWRNSMNGSWFIQALCAMLKQ-------HA-HTLELL--HILTRVNRKVATEFE S-YSLDATFNAKKQIPCIVS-----MLTKELYFPY------------------ >M_musculus_ENSMUSP00000030747 ------------------------------------------------------------ ---------MDEADRQLLRRCRVRLVSELQVAEL-----------WDALLSRELFTRDM- ------------------------------------------------------------ -----IEDIQQ------AGSGSRRDQARQLVTDLETRGRQALPLFISCLE--DTGQGTLA SLLQSGR-----QAAKQDPEAV-------------------------------------- ---------------------------------------------KPLDHLV--PVVLGP MGLTAKEQRV-VKLDPSQPAVGNLTPVVLGPEELWPARLKPEV----------------- --------------LRPETPRPVDIGSGGAHDVCV-PGK----IRGHADMAYTL---DS- DPCGHCLIINNVNFC-------PSSGLGTRTGSNLDRDKLEHRFRWLRFMVE-VKNDLTA KKMVTALMEMAH-RN--HRALDCFVVVILSHGC-QASHLQFPGAVYGTD----------- --GCSVSIEKIVNIFNGSGCPSLGGKPKLFFIQACGG-------------EQKDHGF-EV ---ACTSSQGRTLDSDSEPDAVPYQEGPRPL----DQLDAVSSLPTPSDILV---SYSTF PG--FVSWRDKKSGSWYIETLDGILEQ-------WA-RSEDLQ--SLLLRVANAVSAK-- ---------GTYKQIPGCFN-----FLRKKLFFKTS----------------- >A_gambiae_AGAP004920-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------VCGRDILHCKTMNTSTLSTAFDEVDNNTRVLSLVASVPEI---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------ISSSVIHE----LEPVDDAHYNM---SH- NRRGVAAVFNHRKFL----------HASERKGTDADCDNIRQVLIYLQFEVR-VYDDLTR KEIKQVLDDLAE-ED--HKNSDCLLVVIMTHGD-D-------DVLHAKD----------- ---GTFNVDRLWENFIGDSCPSLLGKPKLFFIQACRG-------------SSFDTGV-HF ---SQCMTQVAKTVVPYAMRELPQPSIV----PGCPKSSIQYAIPSMADLLV---MYSTY KG--HYSWRNPSTGSWFIRALCDELRE-------HG-NSKELL--QLLTSVSRRVAYEFQ SNVPNNSQIDCQKQMPCIVS-----MLTRRIYFSKK----------------- >D_rerio_ENSDARP00000063081 ------------------------------------------------------------ --------MSKKESTQRILQHKVFLIDTLSVEASFI---------LQNVQQAKLITQRD- ------------------------------------------------------------ -----YNNLSD--------VSERETKIIKLLDKLIGRGEETCQEFIDLLR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------QDCVLENFPVLEGHAIFA----SSVQKVSQYKI---TQ- NPRGICVIINNVDFT----------SMGERRGSDEDQNYLAKVFRWLGFEVV-AHRNKTA AEMKNILQALGR-----TVDGDCFVCCVLSHGV-E-------EGVCGTD----------- --GSLVSVDEIRNPFTGVNCQKLVGKPKLFFIQACRG-------------QRKQLRV-NA ---QADGPGDGESE------------------MEVDGDDFDITIPSDTDFLI---ARSTT DG--HVSYRKPDEGSWFIQSLCRNLEK-------HCPLGADIL--TILLSVNNEVSIQGL H----------SKQMPVHEV-----AMRMKLILPPVNN--------------- >C_intestinalis_ENSCINP00000007986 ------------------------------------------------------------ ---------MLSTHKEKLRTNRHTLCKELVVDEL-----------LQELIGEGIFNDIL- ------------------------------------------------------------ -----ADRVLS--------HQRDFKKNVEFLTLLPGRGPNAFNAFRIALI--NSDQSHLA ELLDPAQGVSQPNESNANDGSGGPELS--------------------------------- ----------ASIFRFESIATANSNLPGTSGTSAPLSRRRPMENTDQSSTSI--ASSQVI YANQGTPPKRNRESSSYIEQMDDAPSPTDSLSNIRSTASVHSLFSRSDVRTQSNTAINHI NTVQSPTS-TKAATSYQINLHQGMDLFDGPTVSDLTVRKSTHQHLMQHTDCYQM-TMRG- RPKGAALIISVEKFH-------PESDLLNREGSEKDRVRLELVLQQIGFQCY-VLINGTA EQIVSTLQTFAELEE--HYDNSCSLVAAMSHGD-A-------GCFYGSD----------- --GVSVAIDTVVNFFSNQNCHSLQKKPKIFLFQACQG-------------DEYDMGV-DE ---VDGPVQAPVGDVDNTS-------------TSSSNDHIRNKLPQKSDMLI---GQATM KG--FAAMRNTKHGSWYIQAFVRVLAR-------HA-CDTDLL--DMMTKVNNILKHKEG W--CPGSVYHRCKVMPEFKS-----SLSKKLYFFPGI---------------- >A_carolinensis_ENSACAP00000013788 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------DHYGM---KK- KRVAFMMCV-----------------TEGRAGAEEDIKKMKKWFRTFKFTLLGDCRNPGQ ETLMQQLRQFRDIINLSNEEISCCLITLMSHGKAN-------GYILDKD----------- --NREISLDGIFSLFNNKTCPKLQGKPKIFIIQACRG-------------EQRDYGT-LV ---AGGKP-------------------------VEPDTWSRPKLPTVSDYFI---VYSSQ RD--HIAVRDENTGSEMISAMDEVFSE-------HG-TQWHIG--DLFTKVNSKMIQRDF H---LEGEEESVKVTIVMES-----TLTKALYL-------------------- >M_domestica_ENSMODP00000005556 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MEDTGTTVDAKSTKNSG---VKLF---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HGSKSVE----SGLS-SDSYKM---DY- PEMGLCIIINNKNFH-------PNTGMSFRSGTDVDAASLSDTFRSLKYEVR-IKNDLTC NEITELLNSVSK-ED--HSQRSSFICVILSHGE-E-------GVIFGTD----------- --R-SVELKRLTCFFRGDKCRSLTGKPKLFIIQACRG-------------TELDCGV-ET ---DSGTD----------------------------EDIACQKIPVEADFLY---AYSTA PG--YYSWRNSKDGSWFIQALCAVLKQ-------HA-HKLEIM--QILTRVNRKVATEFE S-YSLDISFHAKKQVPCIMS-----MLTKELYFSH------------------ >G_gallus_ENSGALP00000017288 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MMTDIKDGPRSGEDVSDARSFPGSK---GMNL---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PASKSVD----SGILPDDSYRM---DY- PEIGVCVIINNKNFH-------RDTGLSSRSGTDADAASVREVFMKLGYKVK-LNNDLSS RDIFKLLKNVSE-ED--HSKRSSFVCVLLSHGD-E-------GLFYGTD----------- --G-PLELKVLTSLFRGDKCRSLAGKPKLFFIQACRG-------------TELDSGI-EA ---DSGP-----------------------------DETVCQKIPVEADFLY---AYSTA PG--YYSWRNAAEGSWFIQSLCRMLKE-------HA-RKLELM--QILTRVNRRVA-EYE S-CSTRQDFNAKKQIPCIVS-----MLTKEFYFPC------------------ >O_latipes_ENSORLP00000010095 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------MASNRPGEDSTDARKDNGELAAGASPA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PDRMDVDG----KPSSHSFRYSL---NF- PTIGLCIIINNKNFD-------RGTGMNQRNGTDIDAASAMKVFSKLGYRVK-IYNDQTV KQIKQLLTDVSR-MD--HSDSASFVCILLSHGD-E-------GVFFGTD----------- --G-SIELKTLTSLFRGDHCKSLVGKPKLFFIQACRG-------------TELDDGI-EA ---DSKED--------------------------------TTKIPVEADFLY---AFSTA PG--YYSWRNTMTGSWFINSLCEMLSK-------YG-KELELL--HIMTRVNHMVAVEFE S-ISTLPGFHAKKQIPCIVS-----MLTKEMYFYP------------------ >A_gambiae_AGAP011951-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ECYDT---SN- ARRGIALIINQVIFS----------SMAVRVGSSKDRTDISTVLQRIGFEVR-VMDDPNR KQLLSALKQLAG-ED--HSHSDCLVVVVMTHGKEN-------NLLYASD----------- ---KSYEANQLWEPFIGDACPSLIGKPKLFFVQACRG-------------KKLDEGV-IQ ---ATISIDSVD--------------------TQSSPGSMRYVIPAMADLLV---MYSTY DG--HYSWRNPSKGSWFIQSLCAELGA-------SA-HCKELL--HILTAVSRRVAYHYQ SNVPDNAKIDAKKQMPCMVS-----MLTKLLYLRPKK---------------- >E_caballus_ENSECAP00000013731 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MADDQDCVVEQGAGDSTSTDAVDAKPDRSSFVPSLFS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------KKKKNGPER-----SITTN----RNREPTYQYNM---NF- EKVGKCVIINNKNFD-------RGTGMGVRNGTDKDAEALFKCFRNLGFDVV-VYNDCSC AKMKSLLKQASE-ED--HRNSACFACILLSHGE-E-------NLIYGTD----------- --G-MTPIKDLTGHFRGDRCKTLLEKPKLFFIQACRG-------------TELDDGI-QA ---DSGPIND------------------------DTDANPRYKVPVEADFLF---AYSTV PG--YYSWRNPGSGSWFVQALCSILNE-------HG-KSLEII--QILTRVNHRVARHFE S-HSDDPRFHQKKQIPCVVS-----MLTKELYF-------------------- >M_mulatta_ENSMMUP00000040583 ------------------------------------------------------------ ---------MDEADRRLLRRCRLRLVEELQVDQL-----------WDALLSRELFKPHM- ------------------------------------------------------------ -----IEDIQR------AGSGSRRDQARQLITDLETRGSQALPSFISCLV--DTGQDMLA SFLRTNR-----QAVKL------------------------------------------- ------------------------------------------------------------ ----------------SKPTLENLTPVVL-----RPEIRKPEV----------------- --------------LRPETPRPVDIGSGGCGDVGA-PES----LRGNADLAYVL---SM- EPCGHCLIINNVNFC-------RESGLSTRTGSSIDCEKLQRRFSLLHFMVE-VKHDLTA KEMVLALLELAR-RD--HSALDCCVVVILSHGC-QASHLQFPGAVYGTD----------- --GCPVSVERIVNIFNGTSCPSLGGKPKLFFIQACGG-------------EQKDHGF-EV ---ASTSPEDESSGSNPEPDATPFQEDLRTF----DQLDAVSSLPTPSDIFV---SYSTF PG--FVSLRDPKSGSWYIETLDNIFEQ-------WA-HSEDLQ--SLLLRVADAVSVK-- ---------GIYKQMPGCFN-----FLRKKLFFKTS----------------- >E_caballus_ENSECAP00000015102 ------------------------------------------------------------ ---------MNEADRQLLRRSRLRLVRELQVDSL-----------WDALLTRELFTPDM- ------------------------------------------------------------ -----IEDIQR--------SGSRRDQARQLIIDLETRGSQALLLFISCLE--DTGQDTLA SFLRTSS-----QAAKQNPEAI-------------------------------------- ---------------------------------------------RPSD-LP--PVVLGP VGLKPEELTA-VKQDPSKLTPGKLTPVVLGPEELWLAKLRPEV----------------- --------------LRPEVPRPVDIGSGGFSDVRA-QDR----LRGNADLAYVL---NA- DPCGHCLIINNVNFY-------LASGLGRRVGSDIDCEKLRQRFSLLHFMVE-VKGDLTA KQMLRALGELAR-RD--HGALDCCVVVILSHGC-QASHLQFPGAVYGTD----------- --GCPVSIESIVNIFNGTGCPSLGGKPKLFFIQACGG-------------EQKDPGC-KV ---DSTSPEDRTPGSDSEPDAVPFQEGPGTF----DQPDAVSSLPTPSDIFV---SYSTF PG--FVSWRDPKSGSWYVETLDGVFEQ-------WA-HSEDLQ--TLLLRVAHAVSEK-- ---------GVYKQIPGCFN-----FLRKKFFFKTY----------------- >T_nigroviridis_ENSTNIP00000022078 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MAGEAAGIPELGGEAEGEHRCEDDVDAKPDRRGRFLLFKS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------KKKNDGQMREQDYCSESHY----RIVSPTFQYRM---SH- QRVGKCIIINNKNFD-------EKTGMNVRNGTDRDAGELYKCFKSLGFDVF-IYNDQTC EKMEHLLREASE-ED--HSDSSCFACILLSHGE-E-------GMIYGTD----------- --G-AMPIKTMTSMFRGDMCKSLVGKPKLFFIQACRG-------------SEFDDGI-QT ---DSGPPNDTM----------------------ETDANPRHKIPVEADFLF---AYSTV PG--YYSWRNPGRGSWFVQALCNVLNE-------FG-KQLEIM--QILTRVNYMVATSFE S-WSEDPRFSEKKQIPCVVS-----MLTKELYFKPC----------------- >P_pygmaeus_ENSPPYP00000017020 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MENTENSVDSKSIKNLE---PKVI---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HGSKSMD----SGISLDNSYKM---DY- PEMGLCIIINNKNFH-------KSTGMASRSGTDVDAANLRETFRNLKYEVR-NKNDLTR EEIVELMRDVAK-ED--HSKRSSFVCVLLSHGE-E-------GIIFGTN----------- --G-PVDLRKITNFFRGDRCRSLTGKPKLFIIQACRG-------------TELDCGI-ET ---DSGVD----------------------------DDMACHKIPVEADFLY---AYSTA PG--YYSWRNSKDGSWFIQSLCAMLKQ-------YA-DKLEFM--HILTRVNRKVATEFE S-FSLDATFHAKKQIPCIVS-----MLTKELYFYH------------------ >P_pygmaeus_ENSPPYP00000002138 ------------------------------------------------------------ ---------MDEADRRLLWRCRLRLVEELQVDQL-----------WDALLSRELFRPHM- ------------------------------------------------------------ -----IEDIQR------AGSGSRRDQARQLIIDLETRGSQALPLFISCLE--DTGQDMLA SFLRTNR-----QAAKL------------------------------------------- ------------------------------------------------------------ ----------------SKPTLENLTPVVLRPEIVRPEIRKPEV----------------- --------------LRPETPRPVDIGSGGFGDVGA-LES----MRGNADLAYIL---SM- DPCGHCLIINNVNFC-------RESGLRTRTGSNIDSEKLRRRFSSLHFMVE-VKGDLTA KEMVLALLELAQ-QD--HGALDCCVVVILSHGC-QASHLQFPGAVYGTD----------- --GCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGG-------------EQKDHGF-EV ---ASTSPEDESPGSNPEPDATPFQEGLRTF----DQLDAISSLPTPSDIFV---SYSTF PG--FVSWRDPKSGSWYVETLDDIFEQ-------WA-HSEDLQ--SLLLRVANAVSVK-- ---------GIYKQMPGCFN-----FLRKKLFFKTS----------------- >E_caballus_ENSECAP00000010379 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------QEAYDM---SG- ARLALTLCV-----------------TKAREGSEADLDALERMFQQLGFEST-TKRDPTA QQFQEELEKFQQAMDAREDLVSCAFVVLMAHGV-E-------GRLKGED----------- --EQMVELESLFEVLNNKNCQALKARPKVYIVQACRG-------------EQRDPGE-TV ---GSDDI-------------------------MMIAKDSPETIPTYTDTLH---IYSTV EG--YIAYRHDKEGSCFIQTLVDVFTE----------RRGPIL--ELLTEVTRRMAEAEL V-----QEGRTRKVNPEIQS-----TLRKRLYLQ------------------- >D_rerio_ENSDARP00000075650 ------------------------------------------------------------ --------MDKKESVDKICENKIFLLETLSVDANFI---------LQHVQQAKLITLRD- ------------------------------------------------------------ -----YNNLSD--------FPQRETKIINLLDKLMGKGEETCHQFIALLR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------QDCVLENFPMLKDHDIFD----SSVQEISPYRI---IK- NPRGICVIINNEIFS---------SGMMSRRGSDKDREYLAKVFHWLGFEVV-EHNNKDT AEIRNILKDLGR-----TVDGDCFVCCILSHGR-R-------EGVCGTD----------- --GNYLSIDEIRDPFTGVKCQKLVGKPKLFFIQGCRG-------------ANSLQACVKV ---EADAGNSKA---------------------KVEGDNLDITIPSDTDFLI---ARSTT NG--HVSYRHVREGSWFIQSLCRNLEK-------HCPRGADIL--TILLYVNNEVSSQKS I----------RKQMPIYEV-----ALTRKLFLRPVNP--------------- >A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------PTFRYRM---DY- KKLGKCVIINNKNFA-------KDTGMRIRNGTDKDAGDLQKCFRGIGFDVS-IYNDLTC DNMEKILGEAAL-EN--HDDAACFACILLSHGE-E-------GLIYGTD----------- --G-CMAIKNLTGLFRGDKCQSLIGKPKLFFIQACRG-------------SEFDAGI-QT ---DSGSSNDNL----------------------EMDANPRYKIPVEADFLY---AYSTV PG--YFSWRNPGKGSWFVQSLCSVLND-------HG-KELEVL--QILTMVNYKVARNYE S-QSDDPRFSQKKQVPCVVS-----MLTKELYF-------------------- >C_familiaris_ENSCAFP00000023986 ------------------------------------------------------------ ---------MDEAERRALRRCRVRLVRELQVAAL-----------WDALLSRELFTAAM- ------------------------------------------------------------ -----VEDLQH------AGSGSRSDQARQLVIDLETRGSQALPLFISCLE--DTGQDALA SCLTMSR-----QAVKQNPEAT-------------------------------------- ---------------------------------------------RPLD-LM--PVVLGP TRLTPEDLR---GKDPSKLTPGKLAPVVLG-----PAELQPQV----------------- --------------VRPSVPRPTDNGSGRFSDVCE-YQESGWWVAGPIKLAYAL---NA- DPCGYCLIINNVNFC-------PESRLTARGGSNIDCEKLQRRFCLLRFTVE-VKWDLTA KQMVQALVELAR-RD--HSALDCCVVVVLSHGC-EASHRQFPGAVYGTD----------- --GCPVSIEKIVNIFNGTGCPSLGGKPKLFFIQACGG-------------EQKDHGF-AV ---ASASPEDRSPGSDSEPDAVPFQEGPGPF----DQLDAVSSLPTPSDIFV---SYSTF PG--FVSWRNTKSGSWYVETLDGVFEQ-------WA-HAEDLQ--TLLLRVANAVSQK-- ---------GVYKQIPGCFN-----FLRKKLYFKM------------------ >M_domestica_ENSMODP00000032734 ------------------------------------------------------------ ---------MLQPDMESFKAQVVSTLTKLSPEE--------------------------- ------------------------------------------------------------ --------------------------LRRFGIYLRNVGEEPRVSRHDLEM--ATKPEELA DLLLKRY------VMTGTPRVLVQVLGQVPRKDLAL------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EWALRRRSPSRCKSMSRMNLKRPYE----DDSSELDRYNM---DR- TRKAFVMCV-----------------KTGRPGAKQDISRIKNWLEKCKFEYT-YCDDPDE EELFEKLTQFRDGINGIKEEVSCCLVTLMAHGG-K-------GHIKTKS----------- --NERVNLSDIFEMFNNENCPALQEKPKIFVIQACRG-------------DKRDGGV-VQ ---ADDEP-------------------------MELDLSEKKRLPTSSDYYI---IYATQ DD--HVAFRHPRDGSVMIQAIDEVFRQ-------HG-KKWHIA--DFFTQVNNLVVHTDF Y-----INRNPAKVVLVMES-----TLTKAVYF-------------------- >A_gambiae_AGAP009832-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------QPLTKAFSAMFSRKQEDSSDTRGMPHGSPIASGSQ---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------TANGIIRPAY----VIERYAAYYPM---NH- KRRGMALIFSHNKYN------VRNVSLPVREGSAIDCKRLKETLELFRFDVK-VYPDFKL EEIKSVIGKVSS-MD--HSDSDCFLVAILTHGE-D------GGIVYAYD----------- ---QPYELSLIWSFFTADNCPSLAGRPKIFVVQACRG-------------NQLDHGV-KV ----------------------------------QKDGVARYSIPTHADFLF---AYATI PG--FMAFRNTTEGSWFINELCKELQE-------NG-HRYDIN--TLLTFVTQKVAYDHE S-VSNMPEYNMRKQTPCVVS-----MLTRLLLFNVV----------------- >O_anatinus_ENSOANP00000019254 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------IDSPMCHPS----PGDENQKRYDM---SK- CREAFLMGV-----------------KKGRSGATEDIEKLRKHLAAFRFSVQ-ECIDPDG KVILQDLREFRDKINGSPYEMSCCLVILMSHGV-N-------GFIKGKD----------- --EKVVDLEEIFKLFNNANCPNLREKPKIFIIQACRGGPNHRSRGIKSKIDRTDGGV-EA ---FDNVPE------------------------EMDDTSNVKRLPTTSDFFI---VYSTQ KG--HVSVRNPLMGSRMIEAMDDVFSR-------YG-KKWQLT--DLFTK--SLLKALPS L-----LEGGIVKVTLEMQS-----TLTRAVYLG------------------- >C_familiaris_ENSCAFP00000032189 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MG EQRNTSSKELAAAEATGQSGKELEVSMENTENSVDAKSFKNAE---TVIV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------KILK----DKYLTKLHYKM---DY- PEMGLCIIINNKNFH-------KSTGMAPRSGTDVDAANLRETFTNLKYEVR-NKNDLTC EEILELMNSVSK-ED--HSKRSSFVCVLLSHGD-E-------GIIFGTN----------- --G-PVDLRKVTGFFRGDYCRSLTGKPKLFIIQACRG-------------TELDCGI-ET ---DSGIE----------------------------DDMACQKIPVEADFLY---AYSTA PG--YYSWRNSKDGSWFIQSLCAMLKL-------YA-HKLEFM--HILTRVNRKVATEFE S-FSLDSAFHGKKQIPCIVS-----MLTKELYLYH------------------ >H_sapiens_ENSP00000221740 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MSN----PRSLEEEKYDM---SG- ARLALILCV-----------------TKAREGSEEDLDALEHMFRQLRFEST-MKRDPTA EQFQEELEKFQQAIDSREDPVSCAFVVLMAHGR-E-------GFLKGED----------- --GEMVKLENLFEALNNKNCQALRAKPKVYIIQACRG-------------EQRDPGE-TV ---GGDEI-------------------------VMVIKDSPQTIPTYTDALH---VYSTV EG--YIAYRHDQKGSCFIQTLVDVFTK----------RKGHIL--ELLTEVTRRMAEAEL V-----QEGKARKTNPEIQS-----TLRKRLYLQ------------------- >P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MENTENSVDSKSIKNLE---PKII---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HGSQSMD----SGISLDNSYKM---DY- PEMGLCIIINNKNFH-------KSTGMTSRSGTDVDAANLRETFRNLKYEVR-NKNDLTR EEIVELMRDVSK-ED--HSKRSSFVCVLLSHGE-E-------GIIFGTN----------- --G-PVDLKKITNFFRGDRCRSLTGKPKLFIIQACRG-------------TELDCGI-ET ---DSGVD----------------------------DDMACHKIPVEADFLY---AYSTA PG--YYSWRNSKDGSWFIQSLCAMLKQ-------YA-DKLEFM--HILTRVNRKVATEFE S-FSFDATFHAKKQIPCIVS-----MLTKELYFYH------------------ >H_sapiens_ENSP00000311032 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MENTENSVDSKSIKNLE---PKII---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HGSESMD----SGISLDNSYKM---DY- PEMGLCIIINNKNFH-------KSTGMTSRSGTDVDAANLRETFRNLKYEVR-NKNDLTR EEIVELMRDVSK-ED--HSKRSSFVCVLLSHGE-E-------GIIFGTN----------- --G-PVDLKKITNFFRGDRCRSLTGKPKLFIIQACRG-------------TELDCGI-ET ---DSGVD----------------------------DDMACHKIPVEADFLY---AYSTA PG--YYSWRNSKDGSWFIQSLCAMLKQ-------YA-DKLEFM--HILTRVNRKVATEFE S-FSFDATFHAKKQIPCIVS-----MLTKELYFYH------------------ >D_rerio_ENSDARP00000019984 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MDKEALTSENEVSGDDQENYGKGDVTDAKP DPKAMCRVDKE-ALTSEIEVLEEDQDSYGEEDVTDAKPDRKGRFRLFGN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------FKKNDGKLQEKG-ESESHY----RIVSPTFQYKM---SH- QRVGKCIIINNKNFD-------EKTGMNVRNGTDRDAGELFKCFKSLGFDVA-VYNDQTC RNMERLLKAVSE-ED--HSDSSCFACILLSHGE-E-------GMIYGTD----------- --G-AMPIKTMTSLFKGDVCKSLVGKPKLFFIQACRG-------------SEFDDGV-QT ---DSGPPNDTI----------------------ETDANPRHKIPVEADFLF---AYSTV PG--YYSWRNPGRGSWFVQALCNVLSE-------FG-KQLEIM--QILTRVNYMVATSFE S-WSEDPRFSEKKQIPCVVS-----MLTKELYFN------------------- >G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------MDKLYRDV----QSGEDKYRYKM---DY- PCMGTCVIINIKNFD-------LKTGLETRNGTDVDAAELEKTFSKLGYKVT-LVHDQTA DQIVDLLRDVST-QD--HSNSGSFVCVLLSRGD-E-------GGIYGTD----------- --GSFVNLDELTKFVDGNGCRSLVGKPKLLFIQAARG-------------NKLDDGT-LS ---EGDSM----------------------------DGQTPSRIPVEADFLY---AYSTT PG--FNAWRDTQNGSWFMQSLCEMLRR-------FS-GQLELM--QIMTRVNNKVALEYK T----TPGRSGKRQMPCIVS-----LLTKEFYFP------------------- >T_rubripes_ENSTRUP00000031759 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------SMQMAGEPTEISDLGGEVEEGGQSEDDVDAKPDRKGRFLLFKS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------KKNKDGQMREQDYCSESHY----RIVSPTFQYKM---SH- QRVGKCIIINNKNFD-------EKTGMNVRNGTDRDAGELFKCFKTLGFDVF-IYNDQTC EKMERLLREASE-ED--HSDSSCFACILLSHGE-E-------GMIYGTD----------- --G-AMPIKTMTSMFRGDMCKSLVGKPKLFFIQACRG-------------SEFDDGI-QT ---DSGPPNDTM----------------------ETDANPRHKIPVEADFLF---AYSTV PG--YYSWRNPGRGSWFVQALCNVLSE-------FG-KQLEIM--QILTRVNYMVATSFE S-WSEDPRFSEKKQIPCVVS-----MLTKELYFKQC----------------- >E_caballus_ENSECAP00000019797 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MENSKISVDSKSIKNSE---TKIL---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HGSKSMD----SGISLDSSYKM---DY- PEMGLCIIINNKNFH-------KSTGMASRSGTDVDAANLRETFTNLKYEVR-NKNDLTG EEIVALMRSVSK-ED--HSKRSSFICVLLSHGE-E-------GIIFGTN----------- --G-PIDLKKLTCFFKGDCCRSLAGKPKLFIIQACRG-------------TELDSGI-ET ---DSGIE----------------------------DDMACQKIPVEADFLY---AYSTA PG--YYSWRNSKDGSWFIQSLCAMLKL-------YA-HKLELM--HILTRVNRKVAMEFE S-YCLDPTFHGKKQIPCIVS-----MLTKELYFYH------------------ >B_taurus_ENSBTAP00000008706 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------S----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------KKKKNDSGK-----SVNIP----RDRVPTYQYNM---NF- EKVGKCIIINNKNFD-------RITGMGVRNGTDKDAEALFKCFRSLGFDVS-VYNDCSC AKMQDLLKKASE-ED--HRNSACFACILLSHGE-E-------NLIYGTD----------- --G-KTAIKDLTAHFRGDRCKTLLEKPKLFFIQACRG-------------TELDDGI-QA ---DSGPIND-------------------------TDANPRYKIPVEADFLF---AYSTV PG--YYSWRNPGSGSWFVQALCSILNE-------HG-KSLEIL--QILTRVNDRVARHFE S-QSDDPRFHEKKQIPCVVS-----MLTKELYF-------------------- >T_rubripes_ENSTRUP00000044662 --------------------CNMDFQARLLKVGNDLRKDEVRALVFLCSDILGCNPAAVQ SAGDLFSRLSDQDHLSEEQPHLLVELLGIIQRTKLLRDHNLPRTGAQDLISPYSCKSRK- -------------------------------------------------LLYSLSEELTA DDLKDIKFLLN--NKLPRGKLEE-VTTLEVFMELEHRALISDTDLGFLESIIQPVCPVLL EKINQFN-----AQNCKMHLILHIFDS--------------------------------- ------------------------------------------------------YLNQIQ LNTQLKALW--LIKKF-DSFLVSFSSNESWIGGSGNRPT----NRCPL------------ LTAASLLE------QS-----------CSFNTLQVGCPD----VSVQGVETYLM---TA- AKRGRCLIINNCNFR--------VSRLKKREGTMVDEASLDKVLKWLGFEVE-IQRDCTS KKMSSLIQELAK-TS--QRDWDCVMCCVLSHGL-E-------GGVYGVD----------- --GGTVEIRKLMEPFSGTNCPSLAGKPKIFFIQACQG-------------SRQQDIV-YT ---DAGTPGHGY--------------------VDNNAVQAKECIPSHADFLL---GMATV PS--FVSFRDGTHGTWYIQSLCQNLAD-------MVPRGCDLI--SILTKVNADVSKKVA W-----IDSGHKTQMPQPAF-----TLTKKIVFPAPNTPHPV----------- >M_mulatta_ENSMMUP00000015808 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MENTENSVDSKSIKSLE---PKII---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HGSKSVD----SGISLENSYKM---DY- PEMGLCIIINNKNFH-------KSTGMASRSGTDVDAANLRETFINLKYEVR-NKNDLTR EEIVELMRNVSK-ED--HSKRSSFVCVLLSHGE-E-------GIIFGTN----------- --G-PLDLKKITSFFRGDCCRSLTGKPKLFIIQACRG-------------TELDCGI-ET ---DSGVE----------------------------DDMACHKIPVEADFLY---AYSTA PG--YYSWRNSKDGSWFIQSLCAMLKQ-------YA-DKLEFM--HILTRVNRKVATEFE S-FSLDATFHAKKQIPCIVS-----MLTKELYFYH------------------ >C_familiaris_ENSCAFP00000016420 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MADDQDCGMEQAAGDSESPDAVDARPDRSSFVPSLFS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RKKKNDSGR-----SIKTA----QDQVPTYQYNM---NF- EKVGKCIIINNKNFD-------KTTGMGVRNGTDKDAEALFKCFRNLGFDVV-IYNDCSC AKMQDLLKKASE-ED--HRNSACFACILLSHGE-E-------NLIYGTD----------- --G-MTAIKDLTAHFRGDRCRTLLEKPKLFFIQACRG-------------TELDDGV-QA ---DSGPIND-------------------------TDANPRYKIPVEADFLF---AYSTV PG--YYSWRSPGSGSWFVQALCSTLNE-------HG-KSLEIL--HILTRVNNRVARHFE S-QSDDPHFHEKKQIPCVVS-----MLTKELYF-------------------- >C_familiaris_ENSCAFP00000023821 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------MVDSEIRQ----AQLLAQEAYDM---SG- ARLALTLCV-----------------TKAREGSEADLDALERMFQQLGFEST-MKRDPTA QQFQEELDKFQQAMDARDDFISCAFVVLMAHGL-E-------GRLKGED----------- --GEMVELEDLFKVLNNKNCRALRAKPKVYIVQACRG-------------EQRDPGE-TV ---SGDDI-------------------------VMITKDNPQTIPTYTDILH---VYSTV EG--YIAYRHDKEGSCFIQTLVDVFTE----------RKGPIL--ELLTEVTRRMAEAEL V-----QEGKPRKVNPEIQS-----TLRKRLYLQ------------------- >C_intestinalis_ENSCINP00000024485 ------------------------------------------------------------ ----------------EFRLLLHQICEGLTGENVSM---------MKFLCKDAIPRSRE- -------------------------------------------------LETALDFMEYF EAKGWIQEGDL---GFLAEVLYRINRHDLLKLLPGVKNRRDYEENFQAQQNNFTTYRVVC FMLADEL-----TEGDLKILK--------------------------------------- ------RLCAGKMSKANVRRSVDVLSWLTCMEEEDLLSEGDLDFIMSILQHL--DNQKPY KLFQRVRMNDNTVTLPKNQQKSNAFQPNSHLPVASGFNSLSKQEYNHT------------ SKLEPQYV------SMENHRAFNGGYNQYNNYQSEIKDT----STMGILDKYPM------ ERRGYCLIINNENFE-----------RQDRTGSGNDTERLENLFKEFGFILD-VRKDLDQ REMEKVIQEYTK-KD--HSDKDCFVCVVMSHGL-S-------GCVYGVD----------- --GLSLSTSKISKSFRPGMCSSLTGKPKIFFFQACQG-------------DRTMDGH-SA ---PVDDVESDG-----------------------AASHGRQVLPSESDFLI---GHSTV PG--YLSYRSRTDGSWFISTLVDSLEK-------YH-EKEDLL--SIMINVNQEMASK-- ----------PYKQMPMPIA-----TLRKKVFFSKQNSNSSS----NQNCNTP >D_melanogaster_FBpp0084848 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -MDATNNGESADQVGIRVGNPEQPNDHTDALGSVGSGGAGSSGLVAGSSH---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----PYG------SGAIGQLANGYSSPSSSYRKNVAKM----VTDRHAAEYNM---RH- KNRGMALIFNHEHFE--------VPTLKSRAGTNVDCENLTRVLKQLDFEVT-VYKDCRY KDILRTIEYAAS-QN--HSDSDCILVAILSHGE-M-------GYIYAKD----------- ---TQYKLDNIWSFFTANHCPSLAGKPKLFFIQACQG-------------DRLDGGV-TM ---QRSQTETDG------------------------DSSMSYKIPVHADFLI---AYSTV PG--FYSWRNTTRGSWFMQSLCAELAA-------NG-KRLDIL--TLLTFVCQRVAVDFE SCTPDTPEMHQQKQIPCITT-----MLTRILRFSDKQLAPAGRV--------- >M_musculus_ENSMUSP00000091238 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MENNKTSVDSKSINNFE---VKTI---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HGSKSVD----SGIYLDSSYKM---DY- PEMGICIIINNKNFH-------KSTGMSSRSGTDVDAANLRETFMGLKYQVR-NKNDLTR EDILELMDSVSK-ED--HSKRSSFVCVILSHGD-E-------GVIYGTN----------- --G-PVELKKLTSFFRGDYCRSLTGKPKLFIIQACRG-------------TELDCGI-ET ---DSGTD----------------------------EEMACQKIPVEADFLY---AYSTA PG--YYSWRNSKDGSWFIQSLCSMLKL-------YA-HKLEFM--HILTRVNRKVATEFE S-FSLDSTFHAKKQIPCIVS-----MLTKELYFYH------------------ >G_aculeatus_ENSGACP00000008661 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------QVNGA-RLTSAQDVA--AEEGGPTGDQTDAKPDRRGRFLLFGNI---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------KKNKDGQTREQDYSSESHY----RVVSPTFQYKM---SH- QRVGKCIIINNKNFD-------EKTGMNVRNGTDRDAGELFKCFKSLGFDVF-IYNDQTC GKMESLLREASE-ED--HSDSSCFACILLSHGE-E-------GMIYGTD----------- --A-AMPIKSMTSLFRGDMCKSLVGKPKLFFIQACRG-------------SEFDDGI-QT ---DSGPPNDTL----------------------ETDANPRHKIPVEADFLF---AYSTV PG--YYSWRNPGRGSWFVQALCNVLNE-------FG-KQLEIM--QILTRVNYMVATSFE S-WSEDPRFSEKKQIPCVVS-----MLTKELYFN------------------- >M_mulatta_ENSMMUP00000024183 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MSN----LRSSEEEKYDM---SG- ARLALTLCV-----------------TKAREGFEEDLDALEYMFRQLRFEST-MKRDPTA QQFQEELEKFQQAIDSREDPISCAFVVLMAHGR-E-------GFLKGED----------- --GEMVKLDNLFEALNNKNCQALRAKPKVYIIQACRG-------------EQKDPGE-TV ---GGDEI-------------------------VMVTKDSPQTIPTYTDALH---VYSTV EG--YIAYRHDQKGSCFIQTLVDVFTK----------GKGHIL--ELLTEVTRRMAEAEM V-----QEGQAKKTNPEIQS-----TLRKRLYLQ------------------- >H_sapiens_ENSP00000365051 ----------------------------------RGGRPWGGGGSWGLGRAAEARKRTEA AWSLSWLLAMDEADRRLLRRCRLRLVEELQVDQL-----------WDALLSRELFRPHM- ------------------------------------------------------------ -----IEDIQR------AGSGSRRDQARQLIIDLETRGSQALPLFISCLE--DTGQDMLA SFLRTNR-----QAAKL------------------------------------------- ------------------------------------------------------------ ----------------SKPTLENLTPVVL-----RPEIRKPEV----------------- --------------LRPETPRPVDIGSGGFGDVGA-LES----LRGNADLAYIL---SM- EPCGHCLIINNVNFC-------RESGLRTRTGSNIDCEKLRRRFSSLHFMVE-VKGDLTA KKMVLALLELAQ-QD--HGALDCCVVVILSHGC-QASHLQFPGAVYGTD----------- --GCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGG-------------EQKDHGF-EV ---ASTSPEDESPGSNPEPDATPFQEGLRTF----DQLDAISSLPTPSDIFV---SYSTF PG--FVSWRDPKSGSWYVETLDDIFEQ-------WA-HSEDLQ--SLLLRVSAAFLCK-- ---------GEGRLLRGSVSSWGWGFGVSRAGPNQG----------------- >R_norvegicus_ENSRNOP00000014096 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MDNNETSVDSKSINNFE---TKTI---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HGSKSMD----SGIYLDSSYKM---DY- PEMGLCIIINNKNFH-------KSTGMSARNGTDVDAANLRETFMALKYEVR-NKNDLTR EEIMELMDSVSK-ED--HSKRSSFVCVILSHGD-E-------GVIFGTN----------- --G-PVDLKKLTSFFRGDYCRSLTGKPKLFIIQACRG-------------TELDCGI-ET ---DSGTD----------------------------DDMACQKIPVEADFLY---AYSTA PG--YYSWRNSRDGSWFIQSLCAMLKL-------YA-HKLEFM--HILTRVNRKVATEFE S-FSLDATFHAKKQIPCIVS-----MLTKELYFYH------------------ >O_cuniculus_ENSOCUP00000002346 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ERYDM---SG- ARLALTLCV-----------------TKAREGSEADLDALERMFQQLGFEST-VKRDPTA QQFQEELEKFQQTIDAWKDPVSCAFVVLMAHGD-E-------GVLKGED----------- --EEMVKLEDLFEVLNNKNCKALRAKPKVYIVQACRG-------------EHRDLGE-TV ---GEDQV-------------------------MMITRDSPQTIPTYTDTLH---VYSTV EG--YIAYRHDQEGSCFIQTLTDVFMN----------RTGPIL--ELLTEXXXXXXXXXX X-----QEGKARKVNPEIQS-----TLRKRLYLQ------------------- >T_nigroviridis_ENSTNIP00000001216 ------------------------------------------------------------ SAYQLFLSLCDQDHLSEERPHLLSELLSIIQRTRLLRDLDLRSSATSNLISAY----RK- -------------------------------------------------LLYSLSEDLTD DNLKEIKFLLT--ETLPRRKLEDNVTTLEVFLELECMDLLSKTNLGLLKSILQPVCPVLA ERIRQFE-----AQN--------------------------------------------- ------------------------------------------------------------ -SCQPAADWGFAVKKITDPLQVQ--------GGSDALPSLPEENQSSS------------ RTEASVMS------SANAVGIKPGTLMLGLSPPPVGSPN----FPVQDLGTYPM---TT- LPRGCCLIISNYDFQ--------GSGLGMRNGTRTDEECLKKVFEWLGFKVE-IHRDCTG KEILSLMQELAD-KS--QQRWDCLVCCILSHGL-E-------GCVHGVD----------- --GDQVSIKKLIEPFLGTNCPAMAGKPKLFFIQACQG-------------KKQQGVV-HL ---ESDGAEHSD--------------------VDTDAVRLSNCIPSHADFLL---GMATV PD--YVSYRDRERGTWYIQSLCEYLVK-------MVPRGFDLM--SILTKVNEDVSKKND -------NTGDRKQMPQPVF-----TITKRIVFPVPSGPAPVLPHFPFVEDSP >A_aegypti_AAEL003444-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MDTTDELDVLGFGSRTNESSKSI---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------KEALV----SRAALDEYYDT---TN- KRRGIALVFCHMNFS----------VMAKRNGADKDRDDICNTLYGLDFDVR-VFDDLSR KEVLDRLKDVSR-ED--HSDNDCLVVVMMSHGE-Q-------GVLYARD----------- ---NKYNVDSLWKNFVGNACPSLIGKPKMFFIQACRG-------------EQFDEGV-AY ---AAKSPKDMV---------------------DSRQEQVLYSIPAMADLLV---MYSTY DG--YYSWRNPRQGSWFIQSLCTELDE-------NG-RVRDLL--TLLTGVSRRTAYEFQ SFVPHNAKMDAMKQIPCIVS-----MLTKTFYFTKKTRSRVVTDID------- >P_troglodytes_ENSPTRP00000056642 ----------------------------------RGGRPWGGGGSWGLGRAAEARKRTEA AWSLSWLLAMDEADRRLLRRCRLRLVEELQVDQL-----------WDALLSRELFRPHM- ------------------------------------------------------------ -----IEDIQR------AGSGSRRDQARQLIIDLETRGSQALPLFISCLE--DTGQDMLA SFLRTNR-----QAAKL------------------------------------------- ------------------------------------------------------------ ----------------SKPTLENLTPVVL-----RPEIRKPEV----------------- --------------LRPETPRPVDIGSGGFGDVGA-LES----LRGNADLAYIL---SM- EPCGHCLIINNVNFC-------RESGLRTRTGSNIDCEKLRRRFSSLHFMVE-VKGDLTA KEMVLALLELAR-QD--HGALDCCVVVILSHGC-QASHLQFPGAVYGTD----------- --GCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGG-------------EQKDHGF-EV ---ASTSPEDESPGSNPEPDATPFQEGLRTF----DQLDAISSLPTPSDIFV---SYSTF PG--FVSWRDPKSGSWYVETLDDIFEQ-------WA-HSEDLQ--SLLLRVSAAFLCK-- ---------GEGRLLRGSVSSWGWGFGVSRAGPNQG----------------- >A_gambiae_AGAP012544-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MDATIINNNHSSLEAMDS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TLQLTLHSYNM---AH- PKRGIAVVINNN---------------RDRKGSEKDVKALQAVLSHLQFDVR-LLSDKTT VEIRHALKEVSK-ED--HTNNDCLAIIAMAHGY-N-------DRIKFDD----------- ---DYLHIDELWTNFVGNKCPSLIGKPKLVFIQSCRG-------------GKLDYGA-SI ---ATADARPGL------------------------EEPVDVKIPMYADLLV---MYSSF EH--HSSIRCRNEGSWFIQSFCQVLGA-------NI-AKTELQ--ALLCHVSYLVSIRSD Q--TIDPEGKVVKQIPMVTS-----MLTKAFYFVPK----------------- >B_taurus_ENSBTAP00000021099 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MENTENSVDSKSIKTSE---TKIL---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HGSKSMD----SGISLEESYKM---DY- PEMGLCIIINNKNFH-------ENTGMCRRSPTDDSVAQXRETFMNLKYEVR-IKNDLTC KEMLELMSNVSK-ED--HSKRSSFICVLLSHGE-E-------GIIFGTN----------- --G-PVNLKKLASFFRGDYCRSLTGKPKLFIIQACRG-------------TELDCGI-ET ---DSGAE----------------------------DDMACQKIPVEADFLY---AYSTA PG--YFSWRNAKNGSWFIQALCEMLKK-------HA-HRLELM--HILTRVNRKVAIEYE S-FSTDSAFHAKKQIPCIMS-----MLTKELYF-------------------- >G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MSPRNGTDVDAADAFRTFSKLGYKVT-VANDQTV DQMIQLLVKVSK-QD--HSNSASFVCVLLSHGD-E-------GVIYGTD----------- --G-FEKLDDLTKFFKGDRCRSLVGKPKLFFIQACRG-------------TELDEGS-QI ---EADSV----------------------------GGQTSDRIPVEADFLY---AYSTA PG--YYAWRNTQNGSWFMQSLCEMLRR-------FS-GQLELM--QIMTRLNHRVALHFE S-SSDTPGYSGKKQIPCIVS-----MLTKDFYFPK------------------ >G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------DKYRYKM---DY- PCMGTCVIINNKTFD-------PKTGLSPRNGTDVDAAELEKTFSRLGYKVT-VANDQTA DQMVDLLADVSK-QD--HRKSASFVCALLSHGD-E-------DGIYGTD----------- --G--TSLDDLTKFFKGDRCRSLVGKPKLFFIQACRG-------------TDTDRGV-NF ---DADST----------------------------DGQMLQSIPLEADFLY---AYSTP SG--YYSWRNTQNGSCFMQSLCEILHS-------FS--QLELM--QIMTRVNYEVALHFE S-SSDKLGYSGKKQIPCIMS-----MLTKDFYFPK------------------ >B_taurus_ENSBTAP00000028116 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------ESKEMSS----PQPLEEETYDM---SG- ARLALTLCV-----------------TKAREGSEADLDALERMFQQLGFEST-MKRDPTA QQFQEELEKFQQAIDAREDFVSCAFVVLMAHGL-E-------GRLKGKD----------- --EKMVELEDLFQALNNKNCRALRAKPKVYIVQACRG-------------EQRDPGE-PV ---TGGHL-------------------------VMITENTPETIPTYTDTLH---VFSTI EG--YIAYRHDQEGSYFIQTLVDVFIN----------KKGPIL--ELLTEVTRRMAEAEM V-----QEGEAKKVNPEIQS-----TLRKQLYLQ------------------- >G_aculeatus_ENSGACP00000007379 ------------------------------------------------------------ ---------MEEIHKRILQRNRINLVRDLDPSSL-----------YDGLLEKGVFTQDM- ------------------------------------------------------------ -----IDEIKS--------AGTRRDQARKLVQDLETRGSRAFAMLLLCLE--ETDQHGLA ELLQRAA-----PAVQIWPAAP-------------------------------------- ---------------------------------------------------------NQP FVLML-----NSREKTTSPSIQYRNPVPVH------------------------------ ----------------LTHCDAHVTAPERENTLTRPPGR----TRRDSIQSYKM---DA- SPCGHCLIINNVEFE-------PDSELSNRKGSNIDCDKLEKRFKALNFIVE-VRTNLKQ RQIKHALSALSK-KD--HSQCDCCVVIMLSHGT-EVSHNRFPGAVYGVD----------- --GQHVPVQLITNYLNGQHCPSLQGKPKLFFIQACGG-------------GERDTGF-EV ---SPDEVEPSIGGADDQTDAIPMSSSSDSLS-LSDEVDARATLPTPSDILV---SYSTF PG--YVSWRDTQSGSWYVETLDQVLEQ-------NA-ATDDLV--TMLMMVNHEVSQNSA K--------GLYKQMPGSFN-----FLRKLLHFQTHA---------------- >C_intestinalis_ENSCINP00000003204 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MSLKSAADVLMSGVPTPHTNENNNVGQSEV---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------DALGSGETPRIYSLPDVTK----MASSEVECYQM---DR- ESRGLALIINNENFH-------HATRMNKRSGTDVDARNLSRIFKKLGFDVQ-VYKDLSC ISMLEVINEVST-MD--HTGNDCCFVAFLSHGD-D-------GCVYGTD----------- ---GIVQIKKIVDQFRGDVCPSLAGKPKIFLFQACRG-------------TLHETSV-QL ---SVDVVDGEDQPC------------------VEVDAAPVPTLPSGSDYLF---CYSVA EG--YYSHRDTLYGSWFIQDFTDVMEQLVLNKGKQQ-DKVDFI--DVLTVVNRKVSARRV E-RSYSQQALGKKQMPCYLS-----MLTKKLYLTPKK---------------- >T_rubripes_ENSTRUP00000040691 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------TNMSANGPSPGGDFTDAKKGAGQQPRSGSSS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------GRVTVDA----KPAAYSFRYSL---DF- PNMGHCIIINNKNFD-------RRTGMNTRNGTDVDAANAMKVFLSLGYKVK-VHNDQTV NQMKQLLVSAAE-ED--HSACASFVCVLLSHGD-E-------GVFFGTD----------- --G-SVELKYLTSLFRGDRCKSLVGKPKLFFIQACRG-------------NDLDGGI-ET ---DSAAD------------------------------SSTTKIPVEADFLY---AFSTA PG--YYSWRNTTSGSWFMQSLCDAISK-------YG-KELELQ--HILTRVNHKVAVDFE S-VSNLPGFDAKKQIPCIVS-----MLTKEMYFS------------------- >T_rubripes_ENSTRUP00000045375 ------------------------------------------------------------ ---------MEERHKKILQRNRTNLVGELDPSSL-----------YDGLIEKRVFTHDM- ------------------------------------------------------------ -----IDEIKS--------SGTRRDQARQLIRDLETRGSRAFPLFLECLQ--ETGHHTLV ELLQDGG-----PAVQIQPPTP-------------------------------------- ------------------------------------------------------VPIDRP VIQPLPVCKSAIRSRVLRGTMTVKAAPPVDVVRRDKAPVI-------------------- --------------PVPQPSTAPSPSPEREYMRLKPQGR----IRRDSIQSYKM---DA- NPSGHCLIINNVDFE-------PRSELNDRKGSNTDCDRLESRFKALNFIVK-VKTNLKQ RQIKHELSALSK-MD--HSQYDCCVVVLLSHGT-EVSHSRFPGAVYGVD----------- --GQFVPVQHITTYLNGQHCPSLQGKPKLFFIQACGG-------------DEKDTGF-EV ---SPDEFEPPVVSAHDQTDAIPMSSSSDSLS-MSDEPDARASLPTPSDILV---SYSTF PG--YVSWRDTQSGSWYIETLDRILEE-------NA-ATDDLV--TMLMMVNHEVSQNQA K--------GLYKQMPGSFN-----FLRKLLYFQS------------------ >O_latipes_ENSORLP00000003208 ------------------------------------------------------------ ---------MEEKHKRILRRNRVHLVKELDLSDL-----------CDVLLRKDVFTQSM- ------------------------------------------------------------ -----INDIKR------QNCETKRDQARKLVKDLETRGNEAFSAFLEGLR--VTGQQNLL ELLQKSA-----PRVHFQPGKS-------------------------------------- ------------------------------------------------TEAG--YLLIQP HPVYIEDAVPKKPRTQPSPRKRERRGGGVKVPHNIFIDKVKSDIF--------------- --------------DSKSRFRNNDNTNVCTHLTRCSRGQ----RSDHDGTASRM---DA- RPCGLCLIINNVEFE-------PKTELSIRKGSNVDCDKLEKRFKSLNFVVE-VRTNLKQ RQIKSELSALSR-KD--HSIYDCCVVVILSHGT-EVSHNRFPGAVYGVD----------- --GNHVSVQEITNYLNGQNCPSLQSKPKIFFIQACGG-------------GEKDIGF-EV ---SPDEAKPSIGGDGDQTDAIPFSSSSESLS-TSDETDAIPTLPTPSDILV---SYSTF PG--YVSWRATVSGSWYVEVLDNILEE-------HA-ATLDLT--TMLTLVNDKVSQNSA K--------GLYKQMPGSFN-----FLRKHVYFQTS----------------- >D_rerio_ENSDARP00000072390 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AFEPYK----KH- KNIGKCLIISNEHFP-------VQFSLNRKKGNSVDERRLSSTFKSLGFHVK-VENNLSA NQMIDALRTVSE-ED--HTDNSCFVCVLMSHGE-E-------GTILGSD----------- --ERWIPVKTLTSLLTSDLCPSLRDKPKIFFLQACRG-------------VEYDPGV-EA ---DSVEASE--------------------------DFFGISDVP-ELDFLC---CYSTV EG--YFAWRNPETGSIFIRELCKTLMD----------CRLEII--QILTRVNHLVAYYFQ S-YTLELETNRKRQMPCFAS-----RLTKDFYLHV------------------ >G_gallus_ENSGALP00000014503 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------KKKNGEEEQPKSSLSNQY----RIVTPTFQYNM---NY- KKVGKCIIINNKNFE-------DKTGMGTRNGTDKDAGDLSKSFRSLGFDVY-TYNDRSC EDMQTLLKQAAE-EN--HSDAACFACILLSHGE-E-------GLIYGTD----------- --G-PMAIKHLTTLFRGDKCKTLIGKPKLFFIQACRG-------------SEFDEGI-QT ---DSGPANDTL----------------------ETDANPRYKIPVEADFLF---AYSTV PG--YYSWRNPGRGSWFVQSLCSVLNE-------HG-KQLEIM--QILTRVNYVVATNFE S-QSDDPRFSEKKQIPCVVS-----MLTKELYF-------------------- >D_rerio_ENSDARP00000024255 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------EQYEM---KG- ERRGVCLIINNYDFS--------ACGWLNREGTDIDHDSLRDVFEWLGFEIL-TRRDCTG DQILQALMDLST-QD--HTQADCVVCCILSHGR-L-------NDIIGVD----------- --GKAVPFKELMETLSPFRCSSLYQKPKLFFIQACRG-------------TQNQRAV-FP ---QTFTEDEDV--------------------LASDAGVPRDSIPEMADYLM---AMSTV PW--YASYRDKSKGTWFIQSLCDNLRL-------LVPRGNDLL--SILTKVNADVSKKSD K-------SGLKKQMPQPEF-----SLTRTVVFPPPGLP-------------- >D_melanogaster_FBpp0071971 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --MTDECVTRNYGVGIRSPNGSENRGSFIMADNTDAKGCTPESLVVGGAT---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------AASPLPANKFVARM----PVERYASEYNM---SH- KHRGVALIFNHEFFD--------IPSLKSRTGTNVDAQELKKAFENLGFAVS-VHKDCKL RDILKHVGKAAE-LD--HTDNDCLAVAILSHGE-H-------GYLYAKD----------- ---TQYKLDNIWHYFTATFCPSLAGKPKLFFIQACQG-------------DRLDGGI-TL ---EKGVTETDG------------------------ESSTSYKIPIHADFLF---SYSTI PG--YFSWRNINNGSWYMQSLIRELNA-------NG-KKYDLL--TLLTFVNQRVALDFE SNVPATPMMDRQKQIPCLTS-----MLTRILRFGDKPNGNKAG---------- >G_gallus_ENSGALP00000019870 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------MSGAERRPAAGRVQLDSKPTPTTTADGNQ---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NITEVDAFDKRQ-----TFDPAVQYKM---NH- QRRGVALIFNHEHFF-------WHLRLPDRRGTLADRNNLKRSLTDLGFEVR-IFDDLKA EDVLKKVFEASR-DD--YSNADCFVCVFLSHGE-N-------DHVYAYD----------- ---AQIKIETITNMFRGDKCQSLVGKPKIFIIQACRG-------------DKHDDPV-LV ---QDSVDSKDETTVNQ----------------TEVDAAGVYTLPAGADFIM---CYSVA QG--YFSHRETVNGSWYIQDLCEALGK-------HG-SSLEFT--ELLTVVNRKVSHRKV D-ICRDINAIGKKQIPCFAS-----MLTKKLYFHPKSK--------------- >M_domestica_ENSMODP00000018104 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------DVYNM---SD- ARLALTLCI-----------------TKNRAGSETDVQALEKMFKALNFKNT-VRRNIPA KGFWEELEKFRDDMDQMKDPVSCCFVVLMAHGE-E-------GILQGVD----------- --GNTIRLDELFCMLTNKNCRALRGKPKVFIVQACRG-------------DQKDPGE-VV KPTSSGGD-------------------------VLLAKERPPKLPTFSDSLH---VYATV EG--YIAYRHEEDGSFFIQTLVDVFTN----------MKGNIL--DLLTEVTRRMADAEL M-----EEGKPRKVNPEVQS-----TLRKLLYL-------------------- >B_taurus_ENSBTAP00000012869 -------------------------------------------------MEGSLGSGRRS GSDGQPAPPKISPTTEELQSRLQETLDLLSSQE--------------------------- ------------------------------------------------------------ --------------------------LRSFRDHLKKVEPPVSQVKLELE---GHSPSGLA KLLAKHY-----YPAAVAKRVLVQVLELLPRAD--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------LLPRWQSAPTDCPVIPRKSLKRSYD----CVDGELYRYDL---SG- RRKAFLMCV-----------------KKNRLGAHQDVQLMKDWLKECKFEPT-LCIDPDK MDLLGKITSFRDELNEIKDDIGCCLVTLMSHGE-E-------GFIKMKD----------- --GEKVSLEDIFEMFNNKNCPALQEKPKIFIIQACRG-------------ERRDSGV-ET ---DDEPM-------------------------DLDDGSEKKRLPTFSDYFI---VYPTQ AD--HVALRDPRTGSVMIKEMTEVFKQ-------YG-NKWHLA--DFFTIVNNRVVHRDF N-----LCNKPVKVSLVMES-----TLTKFVYF-------------------- >X_tropicalis_ENSXETP00000052017 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------MASAKQQSSPSAGQIEKDSSSASQNK-EQKA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NVAETDGWTSRT----LELDPSAEYKM---TH- KRRGLALIFNHEDFY-------WQLRLGSRRGTNTDSMNLNRILTDLGFDVQ-NYYNLRT LDILEKIQEAST-AD--HSNADCFLCVFLSHGE-D-------RHIYSYD----------- ---SLIDIQELTNSFKGDKCESLVGKPKIFIFQACRG-------------EKHDNPV-LP ---TDETDSVTLTNI------------------TEVDAASLYTLPAGADFIM---CYSVA EG--YYSHRETVNGSWYIQDLCEVLKA-------HA-ASLEFT--EILTLVNRKVSQRSV A-FCNDPKAIGKKQIPCFSS-----MLTKKLFLKPKSN---------------