10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000027499 -------------------------------------MEVLRRSSVFAAEIMDAFDRS-------------------------------------------------------------- R_norvegicus_ENSRNOP00000024693 -------------------------------------MEVLRRSSVFAAEIMDAFDRS-------------------------------------------------------------- H_sapiens_ENSP00000314132 -------------------------------------MEVLRRSSVFAAEIMDAFDRS-------------------------------------------------------------- G_gorilla_ENSGGOP00000015296 -------------------------------------MEVLRRSSVFAAEIMDAFDRS-------------------------------------------------------------- M_mulatta_ENSMMUP00000007481 -------------------------------------MEVLRRSSVFAAEIMDAFDRS-------------------------------------------------------------- P_pygmaeus_ENSPPYP00000014939 -------------------------------------MEVLRRSSVFAAEIMDAFDRS-------------------------------------------------------------- B_taurus_ENSBTAP00000011478 -------------------------------------MEVLRRSSVFAAEIMDAFDRS-------------------------------------------------------------- M_domestica_ENSMODP00000020066 -------------------------------------MEVLRRSSVFAAEVMEVFDRS-------------------------------------------------------------- O_anatinus_ENSOANP00000008963 -------------------------------------MEVLRRSSVFAAEVMEVFDRS-------------------------------------------------------------- T_guttata_ENSTGUP00000006267 -------------------------------------MEVLRRSSVFAAEVMEVFDRS-------------------------------------------------------------- A_carolinensis_ENSACAP00000000851 -------------------------------------MDVLRRSSVFAAEVMEVFDRT-------------------------------------------------------------- G_gallus_ENSGALP00000009257 -------------------------------------MEVLRRSSVFAAEVMEVFDRS-------------------------------------------------------------- G_aculeatus_ENSGACP00000006084 -------------------------------------MDMLRRSSVFAA---EVFDRS-------------------------------------------------------------- D_rerio_ENSDARP00000068408 -------------------------------------MEMLRRSSVFAAEVMEVFDRS-------------------------------------------------------------- T_nigroviridis_ENSTNIP00000005841 -------------------------------------MEMLRRSSMFAA---EVFDRS-------------------------------------------------------------- T_rubripes_ENSTRUP00000030263 -------------------------------------MEMLRRSSVFAA---EVFDRS-------------------------------------------------------------- O_latipes_ENSORLP00000002641 -------------------------------------LESMRACGVARVNPAQAFSRSA------------------------------------------------------------- E_caballus_ENSECAP00000000132 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000018321 -------------------------------------MEVLRRSSVFAAEVLDVFDRS-------------------------------------------------------------- G_aculeatus_ENSGACP00000018053 -------------------------------------MEVLRRPSVMAAEVLDVFDRS-------------------------------------------------------------- D_rerio_ENSDARP00000090569 -------------------------------------MNVFARSSVLAAEMMDVFDRT-------------------------------------------------------------- T_rubripes_ENSTRUP00000018728 -------------------------------------MEVLRRSSVFAAEVLDVFDRS-------------------------------------------------------------- O_latipes_ENSORLP00000020538 -------------------------------------MDVLRRSSVFAAEVLDVFERS-------------------------------------------------------------- A_aegypti_AAEL001515-PA -------------------------------------MEMTSP---------------------------------------------------------------------------TL D_melanogaster_FBpp0085443 -------------------------------------MAPTTSPPPKLAKF-----KSSSLDHEIYTANRRGTIATASSDWKALRGGVGGG-----AGGPGSVPNPSNGRSLHAGGPMTR A_gambiae_AGAP011552-PA -------------------------------------MSSTAG--------------AFHQQHQPQQQSPRSPIVAAAVAAAAAIGAVSGGSAGGVVG---------------------- A_aegypti_AAEL001521-PA -------------------------------------MLSAEAPVSHNHHLLPDRLSA--------PALARRKFSFPANLHSTVLHGDPPGSINSGSLQPSSTASFARRRLSNVSDVVTR D_melanogaster_FBpp0087182 -------------------------------------MPGTSYPTN-NDNFSNGFPMATTQSERLLQAQNRRKFSFPATLHSASLLEVGGGPKET-----------TRRRLSNVSDAVTR C_intestinalis_ENSCINP00000019812 -------------------------------------MTSYTSDVNHNSIYETERKNKRTLLADNINSIMRDSVTFVTSSIADLTSSCVSLGDDSVFNS--------------------- C_intestinalis_ENSCINP00000016140 -------------------------------------MTSHESENASGFLKPEMESQRRHSWDGRFSTNKIDLGGESTVCRNDSKGRRRRELRRSHVVTEAPDVTLFEEQDQNNASTIPT D_rerio_ENSDARP00000089067 -------------------------------------MADGKNGETTD-ENELKG----------------------------------------------------------------- O_latipes_ENSORLP00000021005 -------------------------------------MA--------------------------------------------------------------------------------- D_rerio_ENSDARP00000095258 -------------------------------------MS--------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000018700 -------------------------------------MASHPG----------------------------------------------------------------------------- X_tropicalis_ENSXETP00000052058 -------------------------------------MA--------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000032199 -------------------------------------MS--------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000018978 -------------------------------------MADGGREKQDDGDREPRG----------------------------------------------------------------- T_guttata_ENSTGUP00000006866 -------------------------------------MY--------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000031936 RKKGNNGVKDRDWEEQHATGNIIFRGSPDKYLTEQGWMA--------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000012873 QVG----------------------------------ME--------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000017311 -------------------------------------MA--------------------------------------------------------------------------------- H_sapiens_ENSP00000293288 -------------------------------------MDGSGEQP--------------------------------------------------------------------------- T_rubripes_ENSTRUP00000014135 -------------------------------------MS--------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000040259 -------------------------------------MS--------------------------------------------------------------------------------- E_caballus_ENSECAP00000014770 -------------------------------------MS--------------------------------------------------------------------------------- M_domestica_ENSMODP00000017160 -------------------------------------MDGSGEQPR-------------------------------------------------------------------------- A_carolinensis_ENSACAP00000011187 -------------------------------------MS--------------------------------------------------------------------------------- B_taurus_ENSBTAP00000000549 -------------------------------------MASGQGPGPPGQDCDEPDPSS-------------------------------------------------------------- B_taurus_ENSBTAP00000008572 -------------------------------------MS--------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000002788 -------------------------------------MA--------------------------------------------------------------------------------- M_musculus_ENSMUSP00000086454 -------------------------------------MS--------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000010478 -------------------------------------MS--------------------------------------------------------------------------------- H_sapiens_ENSP00000365230 -------------------------------------MS--------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000012163 -------------------------------------MS--------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000022903 -------------------------------------MS--------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000007865 -------------------------------------MS--------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000007577 RSHPGAKSKGASTQR----------------------MS--------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000053903 -------------------------------------ME--------------------------------------------------------------------------------- G_gallus_ENSGALP00000010059 -------------------------------------MS--------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000050759 -------------------------------------MATHGAGGDYPGEDKEKNQGEGGAAGGPSLGAAGD------------------------------------------------ G_aculeatus_ENSGACP00000013488 -------------------------------------MA--------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000017211 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000096467 -------------------------------------MA--------------------------------------------------------------------------------- D_rerio_ENSDARP00000023687 -------------------------------------MAAPSG----------------------------------------------------------------------------- M_domestica_ENSMODP00000024313 -------------------------------------MS--------------------------------------------------------------------------------- E_caballus_ENSECAP00000021385 -------------------------------------MASGQGPGPPGKECGEPAPSS-------------------------------------------------------------- O_latipes_ENSORLP00000017513 QAHT---------------------------------MS--------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000019323 -------------------------------------MDGSGEQP--------------------------------------------------------------------------- G_aculeatus_ENSGACP00000017662 -------------------------------------MS--------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000005643 -------------------------------------MS--------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000005209 -------------------------------------MDGSGEQP--------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000010122 -------------------------------------MS--------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000002775 -------------------------------------MS--------------------------------------------------------------------------------- M_musculus_ENSMUSP00000077757 -------------------------------------MASGQGPGPPKVGCDE--SPS-------------------------------------------------------------- O_cuniculus_ENSOCUP00000002204 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000002093 -------------------------------------MA--------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000003768 -------------------------------------MA--------------------------------------------------------------------------------- G_gallus_ENSGALP00000020984 -------------------------------------MA--------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000013781 -------------------------------------MS--------------------------------------------------------------------------------- O_anatinus_ENSOANP00000014671 AAPR---------------------------------MA--------------------------------------------------------------------------------- O_latipes_ENSORLP00000005745 -------------------------------------MASHP------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000036334 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005598 -------------------------------------MA--------------------------------------------------------------------------------- B_taurus_ENSBTAP00000017739 -------------------------------------MDGSGEQP--------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000028328 -------------------------------------MDGSGDHL--------------------------------------------------------------------------- M_musculus_ENSMUSP00000022806 -------------------------------------MA--------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000017228 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000033093 -------------------------------------MDGSGEQL--------------------------------------------------------------------------- A_carolinensis_ENSACAP00000016202 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000001415 -------------------------------------MA--------------------------------------------------------------------------------- M_domestica_ENSMODP00000023449 -------------------------------------FKKNAVIGLNLYCGGAGMGAGGGASGPPSGGRLLASGKGPTVESTPPQRDGGEVETGTAGAGLIGGGIRASPPNPVSPGARGV M_mulatta_ENSMMUP00000019355 -------------------------------------MA--------------------------------------------------------------------------------- H_sapiens_ENSP00000250405 -------------------------------------MA--------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000056677 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000026248 -------------------------------------MA--------------------------------------------------------------------------------- E_caballus_ENSECAP00000008404 -------------------------------------MA--------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000010457 -------------------------------------MA--------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000000576 -------------------------------------MASGQGPGPPKGDCDE--ALS-------------------------------------------------------------- M_musculus_ENSMUSP00000108371 -------------------------------------MA--------------------------------------------------------------------------------- M_domestica_ENSMODP00000006458 -------------------------------------MA--------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000005553 -------------------------------------MDGSGEQS--------------------------------------------------------------------------- G_gallus_ENSGALP00000039057 -------------------------------------MEGNEGDPPGAHRRRDSHGRRPSREI--------------------------------------------------------- E_caballus_ENSECAP00000017850 -------------------------------------MA--------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000015828 -------------------------------------MASGQGPGPPRQECGEPALPS-------------------------------------------------------------- P_troglodytes_ENSPTRP00000050271 -------------------------------------MASGQGPGPPRQECGEPALPS-------------------------------------------------------------- C_familiaris_ENSCAFP00000000102 -------------------------------------MA--------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000010339 -------------------------------------MA--------------------------------------------------------------------------------- H_sapiens_ENSP00000381185 -------------------------------------MA--------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000017121 -------------------------------------MA--------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000008651 -------------------------------------MA--------------------------------------------------------------------------------- 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000027499 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000024693 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000314132 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000015296 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000007481 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014939 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000011478 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000020066 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008963 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006267 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000000851 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000009257 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000006084 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000068408 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005841 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000030263 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000002641 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000000132 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000018321 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018053 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000090569 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000018728 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000020538 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL001515-PA ANNFANVWTNRRSPIHHL------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0085443 AASTSSLASSTRTMTNYQ------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011552-PA -------WTNKRSPIHHL------------------------------------------------------------------------------------------------------ A_aegypti_AAEL001521-PA K------LSSTIGWKQPV------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0087182 K------LSYTIGWKAAQ------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000019812 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000016140 KDDPTPVASENKNTNNRPWGLRRRITKTENHCEKIEDSTPANQTGTPKRRSGIASFATGSSPRNLWQPQKPSVRFTDVNDSNINAATPPDMSSRSFRNRRATVHYSSTGRPSVMERRHPA D_rerio_ENSDARP00000089067 -----------------------------------------------------------------------------------------------------------------------A O_latipes_ENSORLP00000021005 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000095258 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018700 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000052058 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000032199 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018978 -----------------------------------------------------------------------------------------------------------------------A T_guttata_ENSTGUP00000006866 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000031936 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000012873 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000017311 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000293288 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000014135 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000040259 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000014770 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000017160 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011187 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000000549 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000008572 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000002788 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000086454 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000010478 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000365230 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000012163 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000022903 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000007865 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000007577 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000053903 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000010059 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000050759 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013488 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000017211 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000096467 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000023687 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000024313 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000021385 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000017513 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000019323 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000017662 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005643 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000005209 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000010122 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002775 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000077757 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002204 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000002093 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000003768 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000020984 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013781 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000014671 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000005745 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000036334 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005598 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000017739 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000028328 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000022806 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000017228 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000033093 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000016202 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000001415 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000023449 ARPAPIGAEAPDVTTDPMPSLFAPGRCSSAPAEVADGAADVPM----------------------------------CPEEELDGYEPEPPGKRPSRLAVLEIAREGGDSPNGSLPSTPP M_mulatta_ENSMMUP00000019355 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250405 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000056677 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000026248 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000008404 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010457 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000000576 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108371 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000006458 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000005553 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000039057 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017850 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000015828 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000050271 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000000102 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000010339 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381185 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000017121 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000008651 ------------------------------------------------------------------------------------------------------------------------ 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000027499 -----PTDKELVAQAKALGREYVHARLLRAGLSWSAPER-AS------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000024693 -----PTDKELVAQAKALGREYVHARLLRAGLSWSAPER-AS------------------------------------------------------------------------------ H_sapiens_ENSP00000314132 -----PTDKELVAQAKALGREYVHARLLRAGLSWSAPER-AA------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000015296 -----PTDKELVAQAKALGREYVHARLLRAGLSWSAPER-AA------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000007481 -----PTDKELVAQAKALGREYVHARLLRAGLSWSAPER-AA------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014939 -----PTDKELVAQAKALGREYVHARLLRAGLSWSAPER-AA------------------------------------------------------------------------------ B_taurus_ENSBTAP00000011478 -----PTDKELVAQAKALGREFVHARLLRAGLSWSAPER-AA------------------------------------------------------------------------------ M_domestica_ENSMODP00000020066 -----PTDKELVSQAKALGREYIHSRLIRAGLVWSKPEA-KT------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008963 -----PTDKELVSQAKALCREYIHSRLIRASLVWSKPDY-NV------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006267 -----PTDKELVSQAKALCRDYINSRLIQAGVSWSKPEY-NA------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000000851 -----PTDKELVSQAKVLCRDFIHSRLIRAGIGWNKPEH-SV------------------------------------------------------------------------------ G_gallus_ENSGALP00000009257 -----PTDKELVSQAKALCRDYINSRLIRAGVSWSKPEH-NT------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000006084 -----PTDKELVSQAKALCRDYIHSRLNRAGMGWSKPES-GR------------------------------------------------------------------------------ D_rerio_ENSDARP00000068408 -----PTDKELVSQSKVLCRDYIHSRLHRAGIGWSKPEH-G------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000005841 -----PTDKELVSQAKALCRDYIHSRLNRAGIGWSKAEN-GP------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000030263 -----PTDKELVSQAKALCRDYIHSRLNRAGVGWSKADH-GL------------------------------------------------------------------------------ O_latipes_ENSORLP00000002641 -----PTDKELVSQAKALCREYIHSRLNRAGIGWSKPEH-AQ------------------------------------------------------------------------------ E_caballus_ENSECAP00000000132 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000018321 -----LTEKELVSHSKALCRDYILSRLTQSGLGWSKSEL-NL------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018053 -----LTEKELVSQSKALCRDYILSRLHQNGQGWSKTEL-HL------------------------------------------------------------------------------ D_rerio_ENSDARP00000090569 -----HTEKELVFQSKELCRDFIHSRITREGLSWSKVEL-DL------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000018728 -----LTEKELVSHSKALCRDYILSRLNQNGLGCSKAEL-NL------------------------------------------------------------------------------ O_latipes_ENSORLP00000020538 -----LSEKELVTQSKALCRDYILSRLHQNGMGWSKAEI-NF------------------------------------------------------------------------------ A_aegypti_AAEL001515-PA -----TTTQDVINQGKCLCGEYIRARLRRSGLLNRKI-L-QR----------------------------------------------------------------LRSTME-------- D_melanogaster_FBpp0085443 -----EYKMDIINQGKCLCGQYIRARLRRAGVLNRKV-T-QR----------------------------------------------------------------LRNILD-------- A_gambiae_AGAP011552-PA -----TTSQDVINQGKCLCGEYIRARLKRSGLLNRKI-L-QR----------------------------------------------------------------LRNSMEHCMAGSGG A_aegypti_AAEL001521-PA -----LPSQDIITQGKCLCGQYIRCRLKKSGVFNRKLGL-QR----------------------------------------------------------------IRSIVG-------- D_melanogaster_FBpp0087182 -----IPAQDIISQGRCLCGHYIKRRLRRSGLFNKKLGL-QR----------------------------------------------------------------IRSILG-------- C_intestinalis_ENSCINP00000019812 -----TSYEEDVRLTTGICRDYICYRLKRDGFGERVTVT--------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000016140 RIALEAKEGKALEQTKDICKDYIVHRLQQRKLANRVKV---------------------------------------------------------------------------------- D_rerio_ENSDARP00000089067 TGGEDVVDDAIIEQSAVLLRGYVIQQATIDDPNIHVSHE-TL-----------------------------------------------------------------GGRPQ-------- O_latipes_ENSORLP00000021005 -----N------VSNRSIVEKYICHKLSKRGYVCGLNGG-QR---ENAAN-----NGSVGDHSPT------------------------------------------------------- D_rerio_ENSDARP00000095258 ------------YYNRELVVFFIKYKLSQRNYPCNHIGL-TE---DTNRT-----DGAEENG-EGAAGATTLVNGTMNRTNASSTGTPPQSPASSPQRQ--------------------- G_aculeatus_ENSGACP00000018700 GGDQGNNKDQILELGTVLLKDFIFERVKRHGDSTETVTR-TQL------------------------------------------------------------------GGV-------- X_tropicalis_ENSXETP00000052058 -----H-PRRGGYDHRDIVVKYIHYKLSQKGYEW----E-EGRQQVSAEH----PQASAAISNYSDDGEMPAASAD------------SRGPPQSSL--ASAA--ASSDEET-------- T_rubripes_ENSTRUP00000032199 ------------YNNRELVEHFLRYKLSQRNYPTSLLRP-ED---TDGRT-----EGEKRSPGASNGLLVRSRNRGGAS----------------------------------------- G_aculeatus_ENSGACP00000018978 EGGEDVVDDPIMEQGAVVLRGYVVSRINAEDPSRHVSPE-QL-----------------------------------------------------------------GGRPN-------- T_guttata_ENSTGUP00000006866 ------------SSNRELVIDFVSYKLSQKGYSWSQLEE-ED---ENRTDFA---GEEDEMDGVLNGSPSWHAATSHIVNGATVHQNSLE------------------------------ X_tropicalis_ENSXETP00000031936 -----Q----SELGSRALVEDFVRYKLCQRSLVP-------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000012873 -----R------ECNRDIVENYICHKLSKRGFAWSFEDV-QD---ENAAN-----NGSVVAPAPTLVRRCHEAGTGPDRDRGSI---------------------SHPCKEP-------- A_carolinensis_ENSACAP00000017311 -----H-PGIRGYDNREIVLRYIHYKLSQKGYDWVASGD-RGN--LAAAA-----AAAAATPSAPTVS--------------------ASLSPELLN---SDP--VSTNAPR-------- H_sapiens_ENSP00000293288 RGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELAL-DP------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000014135 -------------QNRELVIFYIKYKLSQRNYPFNHNGLILE---PPSRT-----DG---------QFVTTQFNGTF---NGASPGTPPATSL--------------------------- R_norvegicus_ENSRNOP00000040259 ------------QSNRELVVDFLSYKLSQKGYSWSQFSD-VE---ENRTEAPEETEPERETPSAINGNPSWHLADSPAVNGATGHSSSLD------------------------------ E_caballus_ENSECAP00000014770 ------------QSNRELVVDFLSYKLSQKGYNWSQFSD-VE---ENRTEAPEGTESEMETPSAINGNPSWHLADSPTGNGATGHSSSLD------------------------------ M_domestica_ENSMODP00000017160 GGAGATSSEQIMRTGAVLLQGFIQDRAGRVAGGAPELLL-DS----------------------------------------------------------------MGDSAP-------- A_carolinensis_ENSACAP00000011187 ------------SSNRALVVDFLSYKLSQRGHSWHEIEM------ESGEEAM---EPANETGNTLNGSPSWHPSPSHVINGASEHPELLEE----------------------------- B_taurus_ENSBTAP00000000549 -----TSEEQVARDTEEVFRSYVFYRHQQEQEAEGAAAP-TD---------------------------------------------------------------PEMVTLH-------- B_taurus_ENSBTAP00000008572 ------------QSNRELVVDFLSYKLSQKGYSWSQFSD-VE---ENRTEAPEGTESDMETPSAINGNASWHLADSPAVNGATGHSRSSD------------------------------ T_nigroviridis_ENSTNIP00000002788 -----R------EYNRDIVEKYIFHKLSKRGFVWRFEEV-QD---QNAAN-----NGSVVAPAPTLVRRCHEAGTGP--DRGSI---------------------PHLCKRT-------- M_musculus_ENSMUSP00000086454 ------------QSNRELVVDFLSYKLSQKGYSWSQFSD-VE---ENRTEAPEETEAERETPSAINGNPSWHLADSPAVNGATGHSSSLD------------------------------ C_familiaris_ENSCAFP00000010478 ------------QSNRELVVDFLSYKLSQKGYSWSQFSD-VE---ENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLD------------------------------ H_sapiens_ENSP00000365230 ------------QSNRELVVDFLSYKLSQKGYSWSQFSD-VE---ENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLD------------------------------ P_pygmaeus_ENSPPYP00000012163 ------------QSNRELVVDFLSYKLSQKGYSWSQFSD-VE---ENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLD------------------------------ P_troglodytes_ENSPTRP00000022903 ------------QSNRELVVDFLSYKLSQKGYSWSQFSD-VE---ENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLD------------------------------ M_mulatta_ENSMMUP00000007865 ------------QSNRELVVDFLSYKLSQKGYSWSQFSD-VE---ENRTEAPEGTESEMETPSAINGNPSWHLVDSPAVNGATGHSSSLD------------------------------ T_nigroviridis_ENSTNIP00000007577 -------------LNRELVIFYIKYKLSQRNYPLSHI---VE---PSSRT-----EG---------QFGTTQSNGTF---NGASPGTPPAPSQ-----H--------------------- X_tropicalis_ENSXETP00000053903 ------------GSSRDLVEKFVCKKLSQKGACGEFSSN-SQ---PKGVS-----NGSSEGPG--------------------------------------------------------- G_gallus_ENSGALP00000010059 ------------SSNRELVIDFVSYKLSQRGHCWSELEE-ED---ENRTDT----AAEAEMDSVLNGSPSWHPPAGHVVNGATVHRSSLE------------------------------ X_tropicalis_ENSXETP00000050759 RSGTGVSTEQILETGELLLNGFISDRLQNNPDVAGARAL-FP-------------------------------------------------------------------GST-------- G_aculeatus_ENSGACP00000013488 ------------NINRELVEFFLSYKLSQKNHPTSLLRP-ED---AGGRT-----EGDKANSASVPGRGSSAGQPGMSSPP--------------------------------------- T_nigroviridis_ENSTNIP00000017211 ----DVVDDPILEQGAVVLRGYVIERIHVEQPSLHVSSE-DL-----------------------------------------------------------------GGRSE-------- D_rerio_ENSDARP00000096467 -----N---EISYDNRNIVEKYLKHKLSKRGYVWKCQSS-AE---EDDTF-----NKAVEESSPNSDRRLQAPSAG-------------------------GGNNSECLIAR-------- D_rerio_ENSDARP00000023687 GGDTGSGNDQILDLGAALLNNFVYERVRRHGDRDAEVTR-SQL------------------------------------------------------------------GGV-------- M_domestica_ENSMODP00000024313 ------------HSNRELVIDFLSYKLSQKGYNWSQFED------ENRTEVLEGA----EIPSTVNGSPSWHPADSRAVSGATGHSSSLD------------------------------ E_caballus_ENSECAP00000021385 -----TSEEQVARDTEEVFRSYVYYRHQQEQEAEGAAAP-AD---------------------------------------------------------------PEMDTLP-------- O_latipes_ENSORLP00000017513 ------------HCNRELVRFYLAYKMSCRDYPVSLLKP-TD---DGGET-----EED-HSDARNRRLVSSEDGRLRRS----------------------------------------- P_troglodytes_ENSPTRP00000019323 RGGGPTSSEQIMKTGALLLQGFIQDRAGRMRGEAPELAL-DP------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000017662 -----N------ECNRHIVEKYICHKLSKRGYAFGFDDV-GE---EDAAS-----NGSMVVPPPTAVRRCREAGP----DGESF---------------------PRLCKRL-------- G_aculeatus_ENSGACP00000005643 -------------QNRELVVFYINYKLSQRNLPLNHIGL-SE---PPNRT-----GGGVEAGAAGGQRGATHSNGTF---NGTSPGTPPASPL--LQQR--------------------- M_mulatta_ENSMMUP00000005209 RGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGETPELAL-DP------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000010122 ------------YDNRELVEYFLGYKLAQRNYPSSLLRP-QE---PDGWT-----EGDKKSPAAVNGLLIRNRSRSGAS----------------------------------------- O_cuniculus_ENSOCUP00000002775 ------------QSNRELVVDFLSYKLSQKGYSWSQFSD-VE---ENRTEAPEGTGPEMETPSAINGNPAWHPADSPAVNGATGHSSSLD------------------------------ M_musculus_ENSMUSP00000077757 -----PSEQQVAQDTEEVFRSYVFYLHQQEQETQGAAAP-AN---------------------------------------------------------------PEMDNLP-------- O_cuniculus_ENSOCUP00000002204 --------QQVARDTEEVFRSYVFHRHRQEQEAEGAAAP-AD---------------------------------------------------------------PEMISLH-------- T_guttata_ENSTGUP00000002093 -----H-PGRRGYDNREIVLKYIHYKLSQRGYDW----A-AGEDRASLPP----DHSASAAAAIAAAAIAAAGTSDHT--------GLVSPHPEPPG---SAT--ASHTPPA-------- R_norvegicus_ENSRNOP00000003768 -----Q-AGRTGYDNREIVMKYIHYKLSQRGYEW----D-TGD--EDSAP-----LRAAPTPGIFSFQPESNRTPAVHRD------TAARTSPLRPL----------VATAG-------- G_gallus_ENSGALP00000020984 -----H-PGRRGYDNREIVLKYIHYKLSQRGYDW----A-AGEDRPPVPP--------APAPAAAPAAVAAAGASSH-------------HRPEPPG---SAA--ASEVPPA-------- T_nigroviridis_ENSTNIP00000013781 -----H-------TNRELVEFYLNYKLSHSNFLTSLRAS-ADAWQSPRIS------------------------------------------------------RRDRSGAS-------- O_anatinus_ENSOANP00000014671 -----TPAPASVSDTRALVADFVGYKLRQKGF---------------------------------------------------------------------------------------- O_latipes_ENSORLP00000005745 GGGDQEKSKELLDVGTKLLKNFICERVRRNLQDDSEVVR-QQL------------------------------------------------------------------GAE-------- T_rubripes_ENSTRUP00000036334 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005598 -----T--PASAPDTRALVADFVGYKLRQKGYACGT---------------------------------------------------------------------------G-------- B_taurus_ENSBTAP00000017739 RGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGETPELGL-EQ------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000028328 GGGGPTSSEQIMKTGAFLLQGFIQDRAERMAGETPELTL-EQ------------------------------------------------------------------------------ M_musculus_ENSMUSP00000022806 -----T--PASTPDTRALVADFVGYKLRQKGYVCGA---------------------------------------------------------------------------G-------- A_carolinensis_ENSACAP00000017228 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000033093 GSGGPTSSEQIMKTGAFLLQGFIQDRAGRMAGETPELTL-EQ------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000016202 ------AEDQVAQETEEVFQSYAFYRYQQEREQTEGDVP-HD---------------------------------------------------------------PEIAAIP-------- G_gorilla_ENSGGOP00000001415 -----T--PASAPDTRALVADFVGYKLRQKGYVCGA---------------------------------------------------------------------------G-------- M_domestica_ENSMODP00000023449 PAEEDEEEDELYGQSLELISRYLREQAVGTK----------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000019355 -----T--PASAPDTRALVADFVGYKLRQKGYVCGA---------------------------------------------------------------------------G-------- H_sapiens_ENSP00000250405 -----T--PASAPDTRALVADFVGYKLRQKGYVCGA---------------------------------------------------------------------------G-------- X_tropicalis_ENSXETP00000056677 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000026248 -----T--PASAPDTRALVADFVGYKLRQKGYVCGA---------------------------------------------------------------------------G-------- E_caballus_ENSECAP00000008404 -----T--PASAPDTRALVADFVGYKLRQKGYVCGA---------------------------------------------------------------------------G-------- P_troglodytes_ENSPTRP00000010457 -----T--PASAPDTRALVADFVGYKLRQKGYVCGA---------------------------------------------------------------------------G-------- R_norvegicus_ENSRNOP00000000576 -----ASEQQVAQDTEEVFRSYVFYLHQQEQETQGAAAP-AN---------------------------------------------------------------PEMDNLS-------- M_musculus_ENSMUSP00000108371 -----Q-AGRTGYDNREIVMKYIHYKLSQRGYEW----D-AGD--ADAAP-----LGAAPTPGIFSFQPESNPMPAVHRD------MAARTSPLRPL----------VATAG-------- M_domestica_ENSMODP00000006458 -----H-PGRRGYDNREIVMKYIHYKLSQRGYEW----D-AGDLRAPASPSLPPVVASAPAVGIFSTQPRNTPLPAEPQDSATSTTAAARNSPLPLPPPAVAA----AAAAG-------- O_cuniculus_ENSOCUP00000005553 RGGGPTSSEQIMKTGALLLQGFIQDRASRMGGQTPELAV-AQ------------------------------------------------------------------------------ G_gallus_ENSGALP00000039057 -----NAEDQVAQETEEVFRSYTFYRYQQEREEGGAEVP-MD---------------------------------------------------------------PEIMEIQ-------- E_caballus_ENSECAP00000017850 -----H-AGRTGYDNREIVMKYIHYKLSQRGYEW----D-AGD--AGAAP-----LGATPVPGIFSSQPGRTPAP-------------ARTSPLLPP---AAP----AGAAG-------- G_gorilla_ENSGGOP00000015828 -----ASEEQVAQDTEEVFRSYVFYRHQQEQEAEGAAAP-AD---------------------------------------------------------------PEMVTLP-------- P_troglodytes_ENSPTRP00000050271 -----ASEEQVAQDTEEVFRSYVFYRHQQEQEAEGAAAP-AD---------------------------------------------------------------PEMVTLP-------- C_familiaris_ENSCAFP00000000102 -----H-AGRTGYDNREIVMKYIHYKLSQRGYEW----D-AGE--AGAAP-----PGAAPAPGI-----------------------------------------------S-------- P_pygmaeus_ENSPPYP00000010339 -----H-AGTTGYDNREIVDEXIHYKLSQRGYEW----D-AGD--VGAAP-----PGAATAPGIFSSQPGHTPHPAASRD------P-ARTSPLPTP---AAP----GAAVG-------- H_sapiens_ENSP00000381185 -----H-AGRTGYDNREIVMKYIHYKLSQRGYEW----D-AGD--VGAAP-----PGAAPAPGIFSSQPGHTPHPAASRD------PVARTSPLQTP---AAP----GAAAG-------- P_troglodytes_ENSPTRP00000017121 -----H-AGRTGYDNREIVMKYIHYKLSQRGYEW----D-AGD--VGAAP-----PGAAPAPGIFSSQPGHTPHPAASRD------PVARTSPLQTP---AAP----GAAAG-------- M_mulatta_ENSMMUP00000008651 -----H-AGRTGYDNREIVMKYIHYKLSQRGYEW----D-AGD--VGAAT-----PGAAPAPGIFSSQPGHTPHPAASRD------PVARTSPLPTP---AAP--AAAAAAG-------- 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000027499 PAPGGRLAEVCTVLLRLGDELEQIRPSVYRNVARQLHIPLQSE----PVVTDAFLAVA--GHIFSA------------G-------------------ITWGKVVSLYSVAAGLAVDCV- R_norvegicus_ENSRNOP00000024693 PAPGGRLAEVCTVLLRLGDELEQIRPSVYRNVARQLHIPLQSE----PVVTDAFLAVA--GHIFSA------------G-------------------ITWGKVVSLYSVAAGLAVDCV- H_sapiens_ENSP00000314132 PVP-GRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHISLQSE----PVVTDAFLAVA--GHIFSA------------G-------------------ITWGKVVSLYAVAAGLAVDCV- G_gorilla_ENSGGOP00000015296 PVP-GRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHISLQSE----PVVTDAFLAVA--GHIFSA------------G-------------------ITWGKVVSLYAVAAGLAVDCV- M_mulatta_ENSMMUP00000007481 PVP-GRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHISLQSE----PVVTDAFLAVA--GHIFSA------------G-------------------ITWGKVVSLYAVAAGLAVDCV- P_pygmaeus_ENSPPYP00000014939 PVP-GRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHISLQSE----PVVTDAFLAVA--GHIFSA------------G-------------------ITWGKVVSLYAVAAGLAVDCV- B_taurus_ENSBTAP00000011478 PVPGGRLAEVCAVLLRLADELELIRPSVYRNVARQLNLSLQSE----TVVTDAFLAVA--TQIFSA------------G-------------------ITWGKVVSLYSVAAGLAVDCV- M_domestica_ENSMODP00000020066 PTPGGKLAEVASILLRLGDELEYIRPNVYRNIARQLNISLQSE----SVVTDAFLAVA--TQIFAA------------G-------------------ITWGKVVSLYAVAAGLAVDCV- O_anatinus_ENSOANP00000008963 PSPGGKLAEVSTILLRLGDELEYIRPNVYRNIARQLNISLHSE----TVVTDAFLAVA--TQIFSA------------G-------------------ITWGKVVSLYAVAAGLAVDCV- T_guttata_ENSTGUP00000006267 PVPGGKLAEVSTILLRLGDELEYIRPNVYRNIARQLNISLHSE----TVVSDAFLAVA--TQIFSA------------G-------------------ITWGKVVSLYAVAAGLAVDCV- A_carolinensis_ENSACAP00000000851 PVPGGKLAEVSNILLRLGDELEYIRPNLYRNVARQLNISLHSE----TVVTDAFLAVA--TQIFSS------------G-------------------ITWGKIVSLYAVAAGLAVDCV- G_gallus_ENSGALP00000009257 PVPGGKLAEVSAILLCLGDELEYIRPNVYRNIARQLNISLHSE----TVVTDAFLAVA--AQIFTA------------G-------------------ITWGKVVSLYAVAAGLAVDCV- G_aculeatus_ENSGACP00000006084 AAPGGGLGDVSSALLWLGDELEYLRPNVYRNVARQLNITVASE----SIVSDAFLAVA--ADIFST------------G-------------------VTWGKVVSLYAVAGALAVDCV- D_rerio_ENSDARP00000068408 --SGGTLAEVSSVLLWLGDELEYLRPNVYRNVARQLNITIASE----NIVSDAFLAVA--AEIFST-EYSRKGLEKHKG-------------------VTWGKIVSLYAVAGALAVDCV- T_nigroviridis_ENSTNIP00000005841 PASGGTLGEASAVLLWLGDELEHLRPNVYCNVARQLNITVASE----SIMSDAFLAVA--ADIFST------------G-------------------VTWGKVVSLYAVAGALAVDCV- T_rubripes_ENSTRUP00000030263 AASGGTLGEVSSVLMWLGAELEYLRPNVYCNVARQLNITVASE----SIMSDAFLAVA--ADIFST-EYILR--QRYEG-------------------VTWGKVVSLYAVAGALAVDCV- O_latipes_ENSORLP00000002641 AGAGGALGEVSSVLLWLGEELEYLRPNVYRNVARQLNITVASE----SIVSDAFLAVA--ADIFSTGRISEKQNHCHKR-------------------ITWGKVVSLYAVAGALAVDCV- E_caballus_ENSECAP00000000132 ------------------DELELIRPSVYRNVARQLNISLQSE----TVVTDAFLAVS--AQIF-A------------G-------------------ITWGKVVSLYLVAAGLAVDCV- T_nigroviridis_ENSTNIP00000018321 SPSSTALADASMVLLCLGDELESMQPSLYRNVARQLNISVAME----NMVSDAFIAVA--TEILST------------G-------------------ITWGKVVSMYAVAGALAVDCV- G_aculeatus_ENSGACP00000018053 SPSSAALAEVSLVLLCLGDELESIRPSLYRNVARQLNISVAME----NMVSDAFIGVA--TEIFST------------G-------------------ITWGKVVSMYAVAGALAVDCV- D_rerio_ENSDARP00000090569 PEPRGVLVDVSVVLLKLGDELECMRPYVYRNIAKQLNISVSVE----AVVSDAFLSVA--TEVIAM-DYATNTVFDFKG-------------------ITWGKVVAIYAVAAGLAVDCV- T_rubripes_ENSTRUP00000018728 SPSSAALADASMVLLCLGDELESMQPSLYRNVARQLNISVAME----NMVSDAFIGVA--TEILST-GTNQRFLTKIQG-------------------ITWGKVVSMYAVAGALAVDCV- O_latipes_ENSORLP00000020538 SPSNAALSEVTMVLLCLGDELECIQPGLYRNVARQLNISVAME----NVVSDAFLGVA--TEIFSA-VFSAKTQQTDSI-------------------ITWGKVVSMYAVAGALAVDCV- A_aegypti_AAEL001515-PA VPNCVVVRETSPILNGMGEELERMHPRLYTNVSRQISVEPWGELTEPDSVCYLLHIVA--KDLFKT------------D-------------------ITWGKVISLFAIAGGLAVDCV- D_melanogaster_FBpp0085443 PGSSHVVYEVFPALNSMGEELERMHPRVYTNISRQLSRAPFGELEDSDMAPMLLNLVA--KDLFRS------------S-------------------ITWGKIISIFAVCGGFAIDCV- A_gambiae_AGAP011552-PA LGGGAVVREALPILNGMGEELERMHPRLYSNVSRQISNEPWGELTEPDTVGYLLHVVA--KDLFKS------------G-------------------ITWGKVISLFAIAGGLAVDCV- A_aegypti_AAEL001521-PA TPTIHVVREVFPALLSVGEELERMYPRVYNGVARQLSRIGRGELKTPETAPVLLSAIA--RDLFRS------------D-------------------ITWGKVVSLFAIAGGLSVDCV- D_melanogaster_FBpp0087182 STSMGIVRDVFPAVQVLGDELERMHPRIYNGVARQICRNPGGEFHTPDAVSLLLGAVG--RELFRV------------E-------------------ITWSKVISLFAIAGGLSVDCV- C_intestinalis_ENSCINP00000019812 EHAPAHNHNLSNKILNLGSGFERMFPKSFRQISRQIGYVFSSE----ATVRRLYFRMG--VHIMGV---------VECN-------------------YTWGRILSLLGLAGAMAVDCI- C_intestinalis_ENSCINP00000016140 TRQQSASRALSRDVIFIASELERMQKHLYSDVSKQIGITLRSE----DVLRKVFFELA--GEILTTEPVTIPKEATVNGETKKEKSRAFVSSGSRIIEITWGRICAVVAIAGGLSIDCV- D_rerio_ENSDARP00000089067 DEEDPQIKEVVDQLLKIADDLNK--NAELQHLIST--VQS-------NCAQDVFMTVA--RSIFDD------------G-------------------INWGRVVALFHLAYRLIFQAL- O_latipes_ENSORLP00000021005 -PAD-PLADIHRVLREAGDELERLYQRDFTEMSRQLYLTS-------TTAKTRFAEVI--DELFRD------------G-------------------VNWGRIIAFFEFGGTVCVECAS D_rerio_ENSDARP00000095258 TNGSGGLDAVKEALRDSANEFELRYSRAFNDLSSQLHITP-------ATAYQSFESVM--DEVFRD------------G-------------------VNWGRIVGLFAFGGALCVECV- G_aculeatus_ENSGACP00000018700 ELSDPNHKKLAMCLQQIGDELDG--NVELQRMMND--SSL-------GPTKDVFLKVA--FEIFSD------------G------------------KFNWGRVVALFYFACRLVIKAL- X_tropicalis_ENSXETP00000052058 PTMQPVPPAVLQTLSRAGDEFSRLYQQDFRQISGLLHLTP-------STVRVRFATVV--EELFHD------------G-------------------VNWGRIVAFFEFGGVMCVESV- T_rubripes_ENSTRUP00000032199 PSAGAGIEAVNAALRDSAEEFEKLFAQAFSDLSSQLDITP-------DTAYQSFKNVM--DEVFKD------------G-------------------VNWGRVVGLFAFGGVLCVECV- G_aculeatus_ENSGACP00000018978 EHQDPQIKEVVKQLMKIADEMNR--NAELQRLISQ--VPG-------NCAQDIFMKVA--KSIFDD------------G-------------------INWGRVVALFHLAYRLIYRAL- T_guttata_ENSTGUP00000006866 VHEIRRAADVRQALREAGDEFELRYRRAFSDLTSQLHITP-------STAYQSFEQVV--NELFRD------------G-------------------VNWGRIVAFFSFGGALCVESV- X_tropicalis_ENSXETP00000031936 EPAGAASCSLHSAMRAAGDEFEERFRQAFSEISTQIHVTP-------GTAYARFAEVA--GSLFQG------------G-------------------VNWGRIVAFFVFGAALCAESV- T_rubripes_ENSTRUP00000012873 PASD-QHAAIHRVLREAGDELERLYQPDFTEMSRQLYLSS-------TTAQRRFAEVI--DELFRD------------G-------------------VNWGRIIAFFEFGGAVCAECAA A_carolinensis_ENSACAP00000017311 EEPDPVPQVVHTTLRQAGDEFSRRYRRDFAQMSGQLHLTP-------STARSRFVAVV--EELFQD------------G-------------------VNWGRIVAFFEFGGMLCVESV- H_sapiens_ENSP00000293288 VPQDASTKKLSECLKRIGDELDS--NMELQRMIAA--VDT-------DSPREVFFRVA--ADMFSD------------G------------------NFNWGRVVALFYFASKLVLKAL- T_rubripes_ENSTRUP00000014135 ---ATSLDTVKEALRDTGNEFELRYTCAFSDLHNQLHITP-------ATAYQSFENVM--DEVFRD------------G-------------------VNWGRIVGLFAFGGALCVECV- R_norvegicus_ENSRNOP00000040259 AREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQVV--NELFRD------------G-------------------VNWGRIVAFFSFGGALCVESV- E_caballus_ENSECAP00000014770 AREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQVV--NELFRD------------G-------------------VNWGRIVAFFSFGGALCVESV- M_domestica_ENSMODP00000017160 LPSDPRTKRLTECLRRIGDELDS--NMELQRMIAA--VET-------DSPREVFFRVA--AEMFSD------------G------------------NFNWGRVVALFYFASKLVLKAL- A_carolinensis_ENSACAP00000011187 EEEENPRVDVSQTLREAGDEFELRYRRAFSDLTSQLHITL-------GTAYQSFEQVV--NELFHD------------G-------------------VNWGRIVAFFSFGGALCVESV- B_taurus_ENSBTAP00000000549 PEPSSTMGQVGRQLAVIGDDINRRYDAEFQAMLQHLQPTA-------DNAYEYFTKIA--SSLFES------------G-------------------INWGRVVALLGFGYRLALHVY- B_taurus_ENSBTAP00000008572 AREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQVV--NELFRD------------G-------------------VNWGRIVAFFSFGGALCVESV- T_nigroviridis_ENSTNIP00000002788 PQSE-QHAAIHRVLREAGDELERLYQPDFTEMSRQLYLTS-------TTAQRRFAEVI--DELFRD------------G-------------------VNWGRIIAFFEFGAAVCAECAA M_musculus_ENSMUSP00000086454 AREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQVV--NELFRD------------G-------------------VNWGRIVAFFSFGGALCVESV- C_familiaris_ENSCAFP00000010478 AREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQVV--NELFRD------------G-------------------VNWGRIVAFFSFGGALCVESV- H_sapiens_ENSP00000365230 AREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQVV--NELFRD------------G-------------------VNWGRIVAFFSFGGALCVESV- P_pygmaeus_ENSPPYP00000012163 AREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQVV--NELFRD------------G-------------------VNWGRIVAFFSFGGALCVESV- P_troglodytes_ENSPTRP00000022903 AREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQVV--NELFRD------------G-------------------VNWGRIVAFFSFGGALCVESV- M_mulatta_ENSMMUP00000007865 AREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQVV--NELFRD------------G-------------------VNWGRIVAFFSFGGALCVESV- T_nigroviridis_ENSTNIP00000007577 QQSLTSLDAVKEALRDTGNEFELRYTCAFSDLHNQLHITP-------ATAYQSFENVM--DEVFRD------------G-------------------VNWGRIVGLFAFGGALCVECV- X_tropicalis_ENSXETP00000053903 ATQGIVGEEVLQALLDASEEFELRYQRAFSDLTAQLHLTQ-------DTAQQSFQQVV--GELFRD------------G-------------------TNWGRIVAFFSFGRALCVESA- G_gallus_ENSGALP00000010059 VHEIVRASDVRQALRDAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQVV--NELFHD------------G-------------------VNWGRIVAFFSFGGALCVESV- X_tropicalis_ENSXETP00000050759 QHSDPSIKRLSECLRKIGDELDA--NIELQRRIEC--VPC-------NSPKQVFFHVA--KELFAD------------G------------------VFNWGRVVALFYFACKLVVKAL- G_aculeatus_ENSGACP00000013488 PPPSGDTEAVKAA