10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 ---------------MAP------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000011840 ---------------MAP------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008035 ---------------MAA------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000012338 ---------------MAA------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250416 ---------------MAA------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010339 ---------------MAA------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000006331 ---------------MAA------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000004152 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021361 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001988 ---------------MAA------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008892 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003642 ---------------MVQ------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003778 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023516 ---------------MVQ------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000006847 ---------------MLQ------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000027488 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000018492 ---------------MST------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011691 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000014960 ---------------MADAQEDKLYKAEYAKS---------------------------------------------------------------------------GRASCKKCKENIA T_nigroviridis_ENSTNIP00000019481 ---------------MAESQNDKLYKAEYAKS---------------------------------------------------------------------------GRASCKKCKENIA O_latipes_ENSORLP00000017176 ---------------MADSQNDKLFRAEYAKS---------------------------------------------------------------------------GQASCKKCKEKIA D_rerio_ENSDARP00000008364 ---------------MADSQDDKLYKAEYAKS---------------------------------------------------------------------------GRASCKKCKDNIA A_carolinensis_ENSACAP00000006218 ---------------MAES-AEKPYRAEYAKS---------------------------------------------------------------------------GRASCKKCGDNIA T_rubripes_ENSTRUP00000037062 ---------------MSESQNDKLYKAEYAKS---------------------------------------------------------------------------GRASCKKCKENIA D_melanogaster_FBpp0112609 ---------------MDI---ELPYLAEYART---------------------------------------------------------------------------GRATCKGCKSTIS H_sapiens_ENSP00000355759 ---------------MAES-SDKLYRVEYAKS---------------------------------------------------------------------------GRASCKKCSESIP M_musculus_ENSMUSP00000027777 ---------------MAEA-SERLYRVEYAKS---------------------------------------------------------------------------GRASCKKCSESIP P_pygmaeus_ENSPPYP00000000162 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000023715 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000004232 ---------------MAEA-TERLYRVEYAKS---------------------------------------------------------------------------GRASCKKCSESIP B_taurus_ENSBTAP00000001113 ---------------MAES-SDKLYRVEYAKS---------------------------------------------------------------------------GRASCKKCKESIP E_caballus_ENSECAP00000017400 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000028737 ---------------MAES-SDKLYRVEYAKS---------------------------------------------------------------------------GRASCKKCSESIP O_anatinus_ENSOANP00000002367 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000007535 ---------------MAES-ADKPYRAEYAKS---------------------------------------------------------------------------GRASCKKCGESIA P_troglodytes_ENSPTRP00000003457 ---------------MAES-SDKLYRVEYAKS---------------------------------------------------------------------------GRASCKKCSESIP X_tropicalis_ENSXETP00000048934 ------------------------------RA---------------------------------------------------------------------------ATIACKKCGDNIA A_aegypti_AAEL011815-PA ---------------MDA--QNLPYVAEYAKS---------------------------------------------------------------------------GRASCKMCKNKID T_guttata_ENSTGUP00000004425 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000038037 ---------------MAET-GDKPYRAEYAKS---------------------------------------------------------------------------GRASCKKCGESIA A_gambiae_AGAP003230-PA ---------------MDA--EQLPFLAEYSKS---------------------------------------------------------------------------NRAMCRLCKQAIA C_elegans_Y71F9AL.18.1 ---------------MIHSNEPLPYAIEYAKS---------------------------------------------------------------------------GRSNCKTCKKNIA A_carolinensis_ENSACAP00000011424 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005989 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000000153 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000026625 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000014791 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000001175 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000000924 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015470 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381740 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025859 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000043156 ---------------MCT------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000016262 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000012158 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014771 ---------------ECS------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000017224 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000015305 ---------------MAES-SDKLYRVEYAKS---------------------------------------------------------------------------GRASCKKCSESIP G_gallus_ENSGALP00000007181 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108098 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029228 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006583 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006181 ---------------MAES-SDKLYRVEYAKS---------------------------------------------------------------------------GRXSCXKCSESIP T_nigroviridis_ENSTNIP00000017650 ------------------------------------------------------------------------------------------------------------------------ C_elegans_E02H1.4 ---------------M-------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000000045 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK1005.1a ---------------MARRVNKKKSPVKAARKIDGQIGRRVVDGVRAKSSRQRHQAVLYQAPTPTVIRRKTTKTAIVKKTVVVVKKGGKVVKKSSKTGQKVKAVKAPKVKAPSKKGNDRL H_sapiens_ENSP00000371419 ---------------MVM------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000009733 ---------------MVM------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000066130 GPSDTRKGQAGSPSRMTL------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000011271 ---------------SDM------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000000233 ---------------TVM------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000010963 ---------------MTV------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000035522 ---------------MTV------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000043695 ---------------MTV------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000004824 ---------------YSM------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000007671 ---------------MTV------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000001773 ---------------MTI------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000027638 ---------------RAM------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000009821 -------------NRITM------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000012495 ---------------MTM------------------------------------------------------------------------------------------------------ 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000011840 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008035 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000012338 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250416 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010339 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000006331 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000004152 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021361 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001988 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008892 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003642 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003778 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023516 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000006847 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000027488 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000018492 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011691 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000014960 KDSLRMAIMVQSPMFDGKVPHWHHFSCFWLRAAAQSP--A--DISGY------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000019481 KDSLRMAIMVQSPMFDGKVPHWHHFSCFWQRAAAQST--S--DIDGF------------------------------------------------------------------------- O_latipes_ENSORLP00000017176 KDSLRMAIVVQSPMFDGKVPHWHHFSCFWQRASVQST--A--DVGGF------------------------------------------------------------------------- D_rerio_ENSDARP00000008364 KDSLRMAIMVQSPMFDGKVPHWHHFSCFWLRAAVQSP--S--DISGF------------------------------------------------------------------------- A_carolinensis_ENSACAP00000006218 KDSLRLAIMVQSPMFDGKVPHWHHFSCFWKRARLISH--A--DVDGF------------------------------------------------------------------------- T_rubripes_ENSTRUP00000037062 KDSLRMAIMVQSPMFDGKVPHWHHFSCFWQRAAAQST--S--DIDGF------------------------------------------------------------------------- D_melanogaster_FBpp0112609 KDTLRIAVMVQSAFHDAKVPNWFHKTCFFKNQRPSSVG----DIQNI------------------------------------------------------------------------- H_sapiens_ENSP00000355759 KDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDV--EVDGF------------------------------------------------------------------------- M_musculus_ENSMUSP00000027777 KDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRQPDV--EVDGF------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000000162 -----------SPMFDGKVPHWYHFSCFWKVGHSIRHPDV--EVDGF------------------------------------------------------------------------- C_familiaris_ENSCAFP00000023715 -----------SPMFDGKVPHWYHFSCFWKVGHSIRHPDV--EVDGF------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000004232 KDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRQPDT--EVDGF------------------------------------------------------------------------- B_taurus_ENSBTAP00000001113 KDSIRMAFMVQSPMFDGKIPHWYHLSCFWKVGFSIWHPDV--EVEGF------------------------------------------------------------------------- E_caballus_ENSECAP00000017400 -----------SPMFDGKVPHWYHFSCFWKVGHSIRHPDV--EVDGF------------------------------------------------------------------------- M_mulatta_ENSMMUP00000028737 KDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDV--EVDGF------------------------------------------------------------------------- O_anatinus_ENSOANP00000002367 -----------SPMFDGKVPHWHHFTCFWKRARVISH--A--EVDGF------------------------------------------------------------------------- M_domestica_ENSMODP00000007535 KDSLRLAIMVQSPMFDGKIPNWHHYACFWKRGLVISQAEL--EVDGF------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000003457 KDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDV--EVDGF------------------------------------------------------------------------- X_tropicalis_ENSXETP00000048934 KGH-GLPMGRNSPMFDGKVPHWHHYSCFWKRARVLSH--G--DIDGF------------------------------------------------------------------------- A_aegypti_AAEL011815-PA KDELRLGAMVQSAFHDGKQAQWYHEKCFFQKLRPTTE--G--DIAHF------------------------------------------------------------------------- T_guttata_ENSTGUP00000004425 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000038037 KDSLRLALMVQSPMFDGKVPHWHHYSCFWKRARIVSH--T--DIDGF------------------------------------------------------------------------- A_gambiae_AGAP003230-PA KDVLRLAAMVQSPMHDGKVAQWYHDDCFFKKQRPATE--G--DVANI------------------------------------------------------------------------- C_elegans_Y71F9AL.18.1 LDQLRMSMNRPSTFFDGNMDSWFHYNCFWIKMIRGRDDINISSIRGV------------------------------------------------------------------------- A_carolinensis_ENSACAP00000011424 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005989 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000000153 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000026625 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000014791 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000001175 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000000924 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015470 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381740 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025859 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000043156 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000016262 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000012158 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014771 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000017224 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000015305 KDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRQPDS--EVDGF------------------------------------------------------------------------- G_gallus_ENSGALP00000007181 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108098 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029228 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006583 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006181 KDSLXMAIMVQXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXX------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000017650 ------------------------------------------------------------------------------------------------------------------------ C_elegans_E02H1.4 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000000045 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK1005.1a TPRVITEYQENPFFYDPQVPEYISASVYHRWITRAVRNGNMKEIKDYYKSKKCQKSAIYTSFAYSFDTSACDEALRQDIKFATEFFKMNNKMEVDNSYHPGKEPNLLQKKTTGRKNYYML H_sapiens_ENSP00000371419 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000009733 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000066130 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000011271 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000000233 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000010963 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000035522 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000043695 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000004824 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000007671 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000001773 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000027638 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000009821 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000012495 ------------------------------------------------------------------------------------------------------------------------ 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000011840 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008035 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000012338 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250416 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010339 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000006331 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000004152 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021361 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001988 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008892 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003642 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003778 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023516 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000006847 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000027488 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000018492 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011691 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000014960 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019481 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000017176 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008364 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000006218 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000037062 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0112609 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000355759 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000027777 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000000162 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000023715 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000004232 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001113 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017400 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000028737 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002367 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000007535 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000003457 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000048934 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL011815-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004425 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000038037 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP003230-PA ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y71F9AL.18.1 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011424 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005989 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000000153 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000026625 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000014791 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000001175 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000000924 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015470 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381740 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025859 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000043156 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000016262 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000012158 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014771 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000017224 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000015305 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000007181 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108098 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029228 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006583 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006181 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000017650 ------------------------------------------------------------------------------------------------------------------------ C_elegans_E02H1.4 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000000045 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK1005.1a GRHTRQIEMGRGGKEGNNALLNYDTRTDEPNPLTKLIEDNVTYTKLYQLCKIPDGPIVEHHIEMHFVTAVRMGHRDLASALAQGPVKMHCNDLHRATLKDQKLPAKILPVSVAKKAYMNK H_sapiens_ENSP00000371419 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000009733 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000066130 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000011271 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000000233 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000010963 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000035522 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000043695 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000004824 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000007671 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000001773 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000027638 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000009821 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000012495 ------------------------------------------------------------------------------------------------------------------------ 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000011840 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008035 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000012338 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250416 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010339 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000006331 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000004152 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021361 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001988 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008892 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003642 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003778 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023516 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000006847 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000027488 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000018492 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011691 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000014960 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019481 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000017176 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008364 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000006218 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000037062 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0112609 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000355759 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000027777 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000000162 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000023715 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000004232 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001113 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017400 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000028737 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002367 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000007535 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000003457 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000048934 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL011815-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004425 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000038037 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP003230-PA ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y71F9AL.18.1 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011424 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005989 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000000153 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000026625 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000014791 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000001175 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000000924 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015470 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381740 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025859 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000043156 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000016262 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000012158 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014771 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000017224 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000015305 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000007181 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108098 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029228 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006583 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006181 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000017650 ------------------------------------------------------------------------------------------------------------------------ C_elegans_E02H1.4 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000000045 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK1005.1a NITPLHTAAISNSTHMLEAMRAVYPTINIPDQDNWYTMHYAACAPGTAPMEFLLKNGGSVTMLTKQTETPLHVAARAGRAVNCTFLMKEMLDLEKGDDGESTIRADRSIINARTRSGNSA H_sapiens_ENSP00000371419 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000009733 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000066130 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000011271 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000000233 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000010963 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000035522 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000043695 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000004824 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000007671 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000001773 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000027638 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000009821 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000012495 ------------------------------------------------------------------------------------------------------------------------ 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000011840 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008035 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000012338 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250416 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010339 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000006331 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000004152 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021361 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001988 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008892 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003642 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003778 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023516 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000006847 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000027488 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000018492 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011691 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000014960 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019481 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000017176 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008364 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000006218 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000037062 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0112609 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000355759 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000027777 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000000162 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000023715 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000004232 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001113 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017400 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000028737 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002367 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000007535 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000003457 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000048934 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL011815-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004425 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000038037 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP003230-PA ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y71F9AL.18.1 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011424 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005989 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000000153 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000026625 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000014791 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000001175 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000000924 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015470 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381740 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025859 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000043156 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000016262 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000012158 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014771 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000017224 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000015305 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000007181 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108098 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029228 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006583 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006181 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000017650 ------------------------------------------------------------------------------------------------------------------------ C_elegans_E02H1.4 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000000045 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK1005.1a LHLAVLRNNLDVVDALLAEPTIVVDNPTSTGQNRLTPLMMACGKGYLEMAKKLVEKGALVEGKDKKKRTPLIHAMLNGQIHTAAFLLAKGASLTLADSSGNTAAHYAAAYGFLDCLKLLA H_sapiens_ENSP00000371419 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000009733 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000066130 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000011271 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000000233 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000010963 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000035522 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000043695 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000004824 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000007671 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000001773 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000027638 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000009821 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000012495 ------------------------------------------------------------------------------------------------------------------------ 610 620 630 640 650 660 670 680 690 700 710 720 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 ------------------------------------------------------------------------------------------------------------------RRQRS- R_norvegicus_ENSRNOP00000011840 ------------------------------------------------------------------------------------------------------------------RRRRS- C_familiaris_ENSCAFP00000008035 ------------------------------------------------------------------------------------------------------------------RRQGTR B_taurus_ENSBTAP00000012338 ------------------------------------------------------------------------------------------------------------------RRRGT- H_sapiens_ENSP00000250416 ------------------------------------------------------------------------------------------------------------------RRRRST P_troglodytes_ENSPTRP00000010339 ------------------------------------------------------------------------------------------------------------------RRRRST P_pygmaeus_ENSPPYP00000006331 ------------------------------------------------------------------------------------------------------------------RRRRSA E_caballus_ENSECAP00000004152 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021361 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001988 ------------------------------------------------------------------------------------------------------------------RRRRAA M_domestica_ENSMODP00000008892 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003642 ------------------------------------------------------------------------------------------------------------------KNSQT- O_latipes_ENSORLP00000003778 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023516 ------------------------------------------------------------------------------------------------------------------INPVT- T_nigroviridis_ENSTNIP00000006847 ------------------------------------------------------------------------------------------------------------------INPVT- T_rubripes_ENSTRUP00000027488 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000018492 -------------------------------------------------------------------------------------------------------------------RTTRR C_intestinalis_ENSCINP00000011691 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000014960 --------------------------------------------------------SDLRWADQEKVKKAIESGG---------ATG-G--KGDQKSGAKGPKTLNDFAVEYAKSNRSTC T_nigroviridis_ENSTNIP00000019481 --------------------------------------------------------SSLRWEDQEKVKKAIESGG---------ATG-G--GTHSKGGAKAEKTLSEFAVEYAKSNRSTC O_latipes_ENSORLP00000017176 --------------------------------------------------------SDLRWADQEAVKKAIESGG---------VAGTG--KGNSGGAAKGEKTLNDFAVEYAKSNRSTC D_rerio_ENSDARP00000008364 --------------------------------------------------------TDLRWDDQEKVKTAIESGG---------ATG-G--KGGQKGAAKGEKTLNDFAVEYAKSNRSTC A_carolinensis_ENSACAP00000006218 --------------------------------------------------------SELRWEDQEKIKKSIEAGG---------AGT----GKATFAAGKTEKNLNDFAVGYAKSNRSTC T_rubripes_ENSTRUP00000037062 --------------------------------------------------------SGLRWEDQEKIKKAVESGG---------ATGAG--GTDSKSGAKEEKTLNEFAVEYAKSNRSTC D_melanogaster_FBpp0112609 --------------------------------------------------------GNLRFADQKELTDLVENIQEVISA-----------QLGKKRSKAFNLALKDFGIEYAKSSRSTC H_sapiens_ENSP00000355759 --------------------------------------------------------SELRWDDQQKVKKTAEAGG---------VTG----KGQDGIGSKAEKTLGDFAAEYAKSNRSTC M_musculus_ENSMUSP00000027777 --------------------------------------------------------SELRWDDQQKVKKTAEAGG---------VAG----KGQDGSGGKAEKTLGDFLAEYAKSNRSMC P_pygmaeus_ENSPPYP00000000162 --------------------------------------------------------SELRWDDQQKVKKTAEAGG---------VTG----KGQDGIGSKAEKTLGDFAAEYAKSNRSTC C_familiaris_ENSCAFP00000023715 --------------------------------------------------------SELRWDDQQKVKKTAEAGG---------VTG-ILCKGQDGGGGKTDKTLADFAAEYAKSNRSTC R_norvegicus_ENSRNOP00000004232 --------------------------------------------------------SELRWDDQQKVKKTAEAGG---------VAG----KGQHGGGGKAEKTLGDFAAEYAKSNRSTC B_taurus_ENSBTAP00000001113 --------------------------------------------------------SELRWDDQQTIKKMAETGG---------ATD-VSGKGQDGVGSKTEKTLIDFGAGYAKSNRSTC E_caballus_ENSECAP00000017400 --------------------------------------------------------SELRWDDQQKVKKTAEAGG---------VAG----KGQGGSGSKAEKTLGDFAAEYAKSNRSTC M_mulatta_ENSMMUP00000028737 --------------------------------------------------------SELRWDDQQKVKKTAEAGG---------VTG----KGQAGIGSKAEKTLGDFAAEYAKSNRSTC O_anatinus_ENSOANP00000002367 --------------------------------------------------------PELRWDDQEKIKKAIETGG---------AAT-GKGGDQDGGGGKGEKTLNDFAAEYAKSNRSTC M_domestica_ENSMODP00000007535 --------------------------------------------------------LELRWDDQQKIKKTIETGG---------LTG--GKGGSQDGGGKGEKTLINFAAEYAKSNRSAC P_troglodytes_ENSPTRP00000003457 --------------------------------------------------------SELRWDDQQKVKKTAEAGG---------VTG----KGQDGIGSKAEKTLGDFAAEYAKSNRSTC X_tropicalis_ENSXETP00000048934 --------------------------------------------------------TELRWDDQEKIKKAVETGG---------ASA---GAGGDAKGGKGEMTLNDFAVEYAKSNRSTC A_aegypti_AAEL011815-PA --------------------------------------------------------EGLRYEDQEKLRKKIATVGNGVVVPSSTSGK----GKGKKRTADQNMVLKDFAVEYAASGRATC T_guttata_ENSTGUP00000004425 -------------------------------------------------------------------------------------------------------------AEYAKSGRASC G_gallus_ENSGALP00000038037 --------------------------------------------------------PELRWEDQEKIKKAIETGG---------PAG--GKGGDQEGGGKAEKSLTDFAAEYAKSNRSTC A_gambiae_AGAP003230-PA --------------------------------------------------------EALRYEDQKKIRDAIAVFAKGVV---PVAGK----GKGKKRTAVEAQSLKDYGVEYAPSGRAMC C_elegans_Y71F9AL.18.1 --------------------------------------------------------DWLRWEDQEKLRQEIQHFKTASP------------PTLTPLCSTTTVILSTIKTEKSLSNRGKC A_carolinensis_ENSACAP00000011424 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005989 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000000153 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000026625 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000014791 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000001175 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000000924 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015470 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381740 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025859 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000043156 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000016262 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000012158 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014771 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000017224 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000015305 --------------------------------------------------------SELRWDDQQKVKKTAEAGG---------VTG----KGQDGTGSKTEKTLGDFAAEYAKSNRSTC G_gallus_ENSGALP00000007181 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108098 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029228 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006583 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006181 --------------------------------------------------------XXXXXXXXXXXXXXXXXXX---------XXX----KGQDGIGSKAEKTLGDFAAEYAKSNRSTC T_nigroviridis_ENSTNIP00000017650 ------------------------------------------------------------------------------------------------------------------------ C_elegans_E02H1.4 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000000045 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK1005.1a SIDDNILSEPNDWQLYPLSVAYLKGHYGIVTWLLEGPHKDKANINAKDNNGATLLSNLLSYADETMHKELLSQIEYLVARKADASLADSSGQTPLHLFSMQRIILKGSGEAAENDAMRMT H_sapiens_ENSP00000371419 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000009733 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000066130 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000011271 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000000233 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000010963 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000035522 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000043695 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000004824 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000007671 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000001773 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000027638 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000009821 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000012495 ------------------------------------------------------------------------------------------------------------------------ 730 740 750 760 770 780 790 800 810 820 830 840 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 -GSGRRVLNEAKKVDN---------------------------GNKATE----------------------------------------------------------------------- R_norvegicus_ENSRNOP00000011840 -GCGRRVLNEAKRVDN---------------------------GNRAT------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008035 GGSGARAFDKAGRVHN---------------------------GNTAG------------------------------------------------------------------------ B_taurus_ENSBTAP00000012338 -AGGRPILNEAERVNN---------------------------GKTVA------------------------------------------------------------------------ H_sapiens_ENSP00000250416 GGGRARALNESKRVNN---------------------------GNTAP------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010339 GGGRARALNESKRVNN---------------------------GNTAP------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000006331 GGGRARALNESKRVNN---------------------------GNTAP------------------------------------------------------------------------ E_caballus_ENSECAP00000004152 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021361 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001988 SSRG------ARAVNE---------------------------TNSVT------------------------------------------------------------------------ M_domestica_ENSMODP00000008892 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003642 -EHERQIQRCLSGPSS---------------------------APQQKS----------------------------------------------------------------------- O_latipes_ENSORLP00000003778 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023516 -KYKRKIRSQTVKPAP---------------------------LKEEET----------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000006847 -KYKRKIRSQIKEEE-----------------------------EEEDT----------------------------------------------------------------------- T_rubripes_ENSTRUP00000027488 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000018492 SARRSKVLTVKADPDN-------------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000011691 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000014960 KGCDQKIEKDQIRVSKKT-------------------------VDAEKP-QLGLIDRWYHTACFVSRREELVFKSEYSAAQLKG------------------------FN-ALRAEDKEE T_nigroviridis_ENSTNIP00000019481 KGCEQKIEKDQIRVSKKT-------------------------IDPEKP-QLGLIDRWYHTACFVSRREELLFKPEYSASQLKG------------------------FN-TLRAEDKEE O_latipes_ENSORLP00000017176 KGCQQKIEKDQIRVSKKV-------------------------VDAEKP-QLGLIDRWYHTACFVSRREELAFKPDYSAAQLKG------------------------FN-VLRAEDKEE D_rerio_ENSDARP00000008364 KGCDQKIEKDQIRVSKKT-------------------------VDPEKP-QLGLIDRWYHTGCFVSRREELIFKPEYSAAQLKG------------------------FA-VLRDEDKEE A_carolinensis_ENSACAP00000006218 KGCEQKIEKGHIRISKKM-------------------------VNPEKP-QLGMIDNWYHTSCFINCRGDLGFLTTFSASQLLG------------------------FG-ILNEEDKEA T_rubripes_ENSTRUP00000037062 KGCEQKIEKDQIRVSKKS-------------------------VDPEKP-QLGLIDRWYHTACFVSWREELVFKPEYNASQLKG------------------------FS-NLRAEDKEE D_melanogaster_FBpp0112609 RGCEQKINKDLVRLRKTV-------------------------YDTEVGMKYGGQPLWHHLECFAQLRSELGWFA--SGEDMPG------------------------FQ-SLADDDQAK H_sapiens_ENSP00000355759 KGCMEKIEKGQVRLSKKM-------------------------VDPEKP-QLGMIDRWYHPGCFVKNREELGFRPEYSASQLKG------------------------FS-LLATEDKEA M_musculus_ENSMUSP00000027777 KGCLEKIEKGQMRLSKKM-------------------------VDPEKP-QLGMIDRWYHPTCFVKKRDELGFRPEYSASQLKG------------------------FS-LLSAEDKEA P_pygmaeus_ENSPPYP00000000162 KGCMEKIEKGQVRLSKKM-------------------------LDPEKP-QLGMIDRWYHPGCFVKNREELGFRPEYSASQLKG------------------------FS-LLATEDKEA C_familiaris_ENSCAFP00000023715 KGCLEKIEKGQIRLSKKM-------------------------LDPEKP-QLGMIDRWYHPNCFVKNREELGFRPEYSASQFKG------------------------FG-LLTPEDKEA R_norvegicus_ENSRNOP00000004232 KGCMEKIEKGQMRLSKKM-------------------------LDPEKP-QLGMIDRWYHPTCFVKNRDELGFRPEYSASQLKG------------------------FS-LLSAEDKEA B_taurus_ENSBTAP00000001113 KSCMEKIDKGQVRLSKKV-------------------------VYPDKP-QLGMVDCWYHPKCFVQKREELGFRPEFSASQLMG------------------------FS-VLTAEDQET E_caballus_ENSECAP00000017400 KGCMEKIEKGQMRLSKKM-------------------------LDPEKP-QLGMIDRWYHPNCFVKNREELGFRPEYSASQLKG------------------------FS-LLSPEDKEA M_mulatta_ENSMMUP00000028737 KGCMEKIEKGQVRLSKKM-------------------------LDPEKP-QLGMIDRWYHPHCFVKNREELGFRPEYSASQLKG------------------------FS-LLAAEDKEA O_anatinus_ENSOANP00000002367 KGCDQKIEKGQVRLSKKM-------------------------VDPVKP-QLGMIDRWYHPDCFVSRRVELGFLPQYNASQLKG------------------------FG-ILKPEDKET M_domestica_ENSMODP00000007535 KGCQQKIEKGQVRLSKKM-------------------------IDPEKP-QLGMIDRWYHPDCFVKCRDELGFLPQYSASQFKG------------------------FS-ILQPEDKET P_troglodytes_ENSPTRP00000003457 KGCMEKIEKGQVRLSKKM-------------------------LDPEKP-QLGMIDRWYHPGCFVKNREELGFRPEYSASQLKG------------------------FS-LLATEDKEA X_tropicalis_ENSXETP00000048934 KGCEKKIEKGQIRISKKM-------------------------VDVERP-QLGMIDRWYHSDCFVSCREELGFLPSYSASQLKA------------------------FS-ILKAEDKDA A_aegypti_AAEL011815-PA RGCEIKILKDEVRIKKMD-------------------------YTTEVGMKYGGQAMWHHAECFAKLRSELGYFE--KGESLPG------------------------FN-QLKKEDKAK T_guttata_ENSTGUP00000004425 KKCGESIAKDSLRLALMM-------------------------VHPEKP-QLGMIDNWYHPDCFVSRRAELGFLPAYGATQLLG------------------------FS-ILKAEDKET G_gallus_ENSGALP00000038037 KGCEQKIEKGQIRISKKM-------------------------VHPEKP-QLGMIDNWYHPDCFVSRRAELGFLPAYGATQLLG------------------------FS-ILKAEDKET A_gambiae_AGAP003230-PA RGCEIKILKDEMRIKKVA-------------------------YDTEVGMKYGGQPLWHHAECFAKLRSELGYFE--KAESLPG------------------------YR-SMKPEDQKI C_elegans_Y71F9AL.18.1 GKCGQNFERGEIKAHNKGKANHFKCFLQEFDKISGTVEDIPGWADYEENFKIKAVGEYVEALAAKRRSTEPATPASASPTPPEA------------------------ETPVLSAEGSPE A_carolinensis_ENSACAP00000011424 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005989 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000000153 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000026625 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000014791 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000001175 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000000924 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015470 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381740 ----------------------------------------------------------MSLLFL-------------------------------------------------------- P_troglodytes_ENSPTRP00000025859 ----------------------------------------------------------MSLLFL-------------------------------------------------------- B_taurus_ENSBTAP00000043156 -------------------------------------------AKGLQTVVRTDCLGGTDPVATTSPRSLLLLAEVTQPSNHAR------------------------SKSAERGEEQRV E_caballus_ENSECAP00000016262 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000012158 ----------------------------------------------------------MSLLFL-------------------------------------------------------- C_familiaris_ENSCAFP00000014771 -------------------------------------------GGRRRPEARRDSPHFSSLIRR-------------------------------------------------------- R_norvegicus_ENSRNOP00000017224 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000015305 KGCMEKIEKXXXXXXXXX-------------------------XXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX------------------------XX-XXXXXXXXX G_gallus_ENSGALP00000007181 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108098 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029228 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006583 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006181 KGCMEKIEKGQVRLSKKM-------------------------LDPEKP-QLGMIDRWYHPGCFVKNREELGFRPEYSASQLKG------------------------FS-LLATEDKEA T_nigroviridis_ENSTNIP00000017650 ------------------------------------------------------------------------------------------------------------------------ C_elegans_E02H1.4 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000000045 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK1005.1a LDNYKKCFNTLIKAGAKVDVYDHEDNTPLHYALTNGNLMLFNLMLDKVANKRNLFEKWANHQNFLHEILALPMKVYGDQVLWKGETLTKPAYDVLPILKELHENLPDLFEKWISEVNKAG H_sapiens_ENSP00000371419 ----------------------------------------------------------------------------------------------------------------------GI P_troglodytes_ENSPTRP00000009733 ----------------------------------------------------------------------------------------------------------------------GI M_musculus_ENSMUSP00000066130 ----------------------------------------------------------------------------------------------------------------------GI G_aculeatus_ENSGACP00000011271 ----------------------------------------------------------------------------------------------------------------------AV T_rubripes_ENSTRUP00000000233 ----------------------------------------------------------------------------------------------------------------------GV C_familiaris_ENSCAFP00000010963 ----------------------------------------------------------------------------------------------------------------------GI B_taurus_ENSBTAP00000035522 ----------------------------------------------------------------------------------------------------------------------GI X_tropicalis_ENSXETP00000043695 ----------------------------------------------------------------------------------------------------------------------AI T_nigroviridis_ENSTNIP00000004824 ----------------------------------------------------------------------------------------------------------------------GV E_caballus_ENSECAP00000007671 ----------------------------------------------------------------------------------------------------------------------GI A_carolinensis_ENSACAP00000001773 ----------------------------------------------------------------------------------------------------------------------AV G_gallus_ENSGALP00000027638 ----------------------------------------------------------------------------------------------------------------------TI M_domestica_ENSMODP00000009821 ----------------------------------------------------------------------------------------------------------------------GM O_cuniculus_ENSOCUP00000012495 ----------------------------------------------------------------------------------------------------------------------GI 850 860 870 880 890 900 910 920 930 940 950 960 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 ----------DDSPPGKKM-----------------------------------------------------------------------RTCQ-------------------------- R_norvegicus_ENSRNOP00000011840 ----------DDSPPGKKV-----------------------------------------------------------------------RTCQ-------------------------- C_familiaris_ENSCAFP00000008035 ----------EDPPPAKKT-----------------------------------------------------------------------RRCQR------------------------- B_taurus_ENSBTAP00000012338 ----------EDPPPAKKI-----------------------------------------------------------------------RKCHR------------------------- H_sapiens_ENSP00000250416 ----------EDSSPAKKT-----------------------------------------------------------------------RRCQR------------------------- P_troglodytes_ENSPTRP00000010339 ----------EDSSPAKKT-----------------------------------------------------------------------RRCQR------------------------- P_pygmaeus_ENSPPYP00000006331 ----------EDSSPAKKT-----------------------------------------------------------------------RRCQR------------------------- E_caballus_ENSECAP00000004152 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021361 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001988 ----------EDSPPVKKT-----------------------------------------------------------------------RRCQK------------------------- M_domestica_ENSMODP00000008892 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003642 ----------TISAPAKRS-----------------------------------------------------------------------R----------------------------- O_latipes_ENSORLP00000003778 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023516 ----------EKQPAAKRK-----------------------------------------------------------------------RAQSK------------------------- T_nigroviridis_ENSTNIP00000006847 ----------NKQPAAKRR-----------------------------------------------------------------------RGQSK------------------------- T_rubripes_ENSTRUP00000027488 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000018492 --GKVTPSATNATVASKRK----------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000011691 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000014960 LEKRLPPVKTE----GKRQ-----------------------------------------------------------------------SDEVD-G---PSKKQ--------KKEEEDE T_nigroviridis_ENSTNIP00000019481 LKKRLPEVKTE----GKRK-----------------------------------------------------------------------ADQVD-G---VSSFAFSTQLLFVFKRNMKN O_latipes_ENSORLP00000017176 LKKRLPAVKTE----GKRP-----------------------------------------------------------------------GDELD-G---VSKKL--------KQEEEEE D_rerio_ENSDARP00000008364 LKKRLPAVKSE----GKRK-----------------------------------------------------------------------ADEVDGG---VSKKQ--------KKEDE-- A_carolinensis_ENSACAP00000006218 LKKELPALKNE----GKRK-----------------------------------------------------------------------GDEVD-GAV-VSKKK--------PKKEKEK T_rubripes_ENSTRUP00000037062 LKRKLPSIKTE----GKRK-----------------------------------------------------------------------SDEVD-G---VSKKK--------KKEEEEE D_melanogaster_FBpp0112609 VKNAIPPIKSEELPDTKRA-----------------------------------------------------------------------KMELS----------------------DTN H_sapiens_ENSP00000355759 LKKQLPGVKSE----GKRK-----------------------------------------------------------------------GDEVD-GVDEVAKKK--------SKKEKDK M_musculus_ENSMUSP00000027777 LKKQLPAIKNE----GKRK-----------------------------------------------------------------------GDEVD-GTDEVAKKK--------SKKGKDK P_pygmaeus_ENSPPYP00000000162 LKKQLPGVKSE----GKRK-----------------------------------------------------------------------GDEVD-GVDEVAKKK--------SKKEKDK C_familiaris_ENSCAFP00000023715 LKKQLPGVKSE----GKRK-----------------------------------------------------------------------GDEVD-GMDEVAKKK--------SKKEKDK R_norvegicus_ENSRNOP00000004232 LKKQLPAVKSE----GKRK-----------------------------------------------------------------------CDEVD-GIDEVAKKK--------SKKGKDK B_taurus_ENSBTAP00000001113 LKKQLPAIKGE----RKRK-----------------------------------------------------------------------GDEVD-GIDEVTKKK--------SKKEKDK E_caballus_ENSECAP00000017400 LKKQLPGVKTE----GKRK-----------------------------------------------------------------------GDEVD-GVDEVAKKK--------SKKEKDK M_mulatta_ENSMMUP00000028737 LKKQLPGVKSE----GKRK-----------------------------------------------------------------------GDEVD-GVDEVAKKK--------SKKEKDK O_anatinus_ENSOANP00000002367 LKKQLPAVKSE----GKRK-----------------------------------------------------------------------GDEVD-GGGVVAKKK--------QKKEKDK M_domestica_ENSMODP00000007535 LKKQLPAVKTE----GKRK-----------------------------------------------------------------------GDEVD-GDD-LAKKK--------PKKEKEK P_troglodytes_ENSPTRP00000003457 LKKQLPGVKSE----GKRK-----------------------------------------------------------------------GDEVD-GVDEVAKKK--------SKKEKDK X_tropicalis_ENSXETP00000048934 LKAMLPAVKNE----GKRK-----------------------------------------------------------------------ADEVD-ASSAGTKKK--------LKKEKEK A_aegypti_AAEL011815-PA VKELLPAIKQEEVP-TKKV-----------------------------------------------------------------------KSEPK------------------DEVDSAK T_guttata_ENSTGUP00000004425 LKKQLPATKSE----GKRK-----------------------------------------------------------------------GEEVD-GNV-TAKKK--------QKKEKEK G_gallus_ENSGALP00000038037 LKKQLPATKTE----GKRK-----------------------------------------------------------------------GEEVD-GNV-VAKKK--------SRKEKEK A_gambiae_AGAP003230-PA LKGLLPAIKAEDVP-AKKV-----------------------------------------------------------------------KEEVK------------------DEVDKAA C_elegans_Y71F9AL.18.1 SSNKRPASSEIIEIDGEGN-----------------------------------------------------------------------PDEND-----FAKKR--------RMKKEAR A_carolinensis_ENSACAP00000011424 -------------MPPKRK-----------------------------------------------------------------------VSAQTPA--PEPEP--------------KP T_rubripes_ENSTRUP00000005989 -------------MPPKRR-----------------------------------------------------------------------AASAARA--GGKKAK---------E--E-T X_tropicalis_ENSXETP00000000153 -------------MAPKRK-----------------------------------------------------------------------AATQAKA--SGKNKKAKVKKEIKEEETEQP D_rerio_ENSDARP00000026625 -------------MAPKRR-----------------------------------------------------------------------AASSTKA--GGKKVK---------QETQPE M_domestica_ENSMODP00000014791 -------------MASKRK-----------------------------------------------------------------------AASASTK--SPKTKK-------------EK G_aculeatus_ENSGACP00000001175 -------------MAPKRR-----------------------------------------------------------------------AASGGKR--GGKKVK---------QEPE-T O_latipes_ENSORLP00000000924 -------------MAPKRR-----------------------------------------------------------------------AASAAKA--GGKKVK---------E----- P_pygmaeus_ENSPPYP00000015470 -------------MAPKRK-----------------------------------------------------------------------PSVQTEG--PE-KKG------------RQA H_sapiens_ENSP00000381740 ------------AMAPKPK-----------------------------------------------------------------------PWVQTEG--PEKKKG------------RQA P_troglodytes_ENSPTRP00000025859 ------------AMAPKRK-----------------------------------------------------------------------PWVQTEG--PEKKKG------------WQA B_taurus_ENSBTAP00000043156 LCKEEPRSGKGTATVPKHK-----------------------------------------------------------------------LQVPHEG--PEKTKG------------RQG E_caballus_ENSECAP00000016262 -------------MTPKRK-----------------------------------------------------------------------APAQHEG--PEKKKG------------RQG G_gorilla_ENSGGOP00000012158 ------------AMAPKRK-----------------------------------------------------------------------PWVQTEG--PE-KKG------------WQA C_familiaris_ENSCAFP00000014771 ------------AMAPKRK-----------------------------------------------------------------------PQVQQEG--PEKKKG------------RQG R_norvegicus_ENSRNOP00000017224 -------------MAPKRK-----------------------------------------------------------------------SSMQTEG----SKKQ------------RQG O_cuniculus_ENSOCUP00000015305 XXXXXXXXXXX----XKRK-----------------------------------------------------------------------GDEVD-GMDEVAKKK--------SKKEKDK G_gallus_ENSGALP00000007181 -------------MAPKRR-----------------------------------------------------------------------APPASQPADGGKKAK------------GGQ M_musculus_ENSMUSP00000108098 -------------MAPKRK-----------------------------------------------------------------------ASVQTEG----SKKR------------RQG M_mulatta_ENSMMUP00000029228 ------------AMAPKRK-----------------------------------------------------------------------CSVQTEG--PEKKKG------------RQG T_guttata_ENSTGUP00000006583 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006181 LKKQLPGVKSE----GKRK-----------------------------------------------------------------------GDEVD-GVDEVAKKK--------SKKEKDK T_nigroviridis_ENSTNIP00000017650 -------------MAPKRR-----------------------------------------------------------------------AAAAAKA--GGKKAK---------E----- C_elegans_E02H1.4 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000000045 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK1005.1a YSPIVEAIKQYQALAANKKLRGEADQNGNPGFGNAIARGRVHNQFGRDRMNQSQAPHCDSYELKTFISTVNELFEWVIRLGPFQLTQKYINSENSAAVTLANLAMSIPIECGRHQQNQLA H_sapiens_ENSP00000371419 FANCIFCLKVKYLPQQQKK----------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000009733 FANCIFCLKVKYLPQQQKK----------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000066130 FANCIFCLKVKYLPRQQKK----------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000011271 FEHSLLLLELKALTPTEKR----------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000000233 FKNCSVLLELKTLPIKEKR----------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000010963 FANCTFYLKVKDLPRQLKK----------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000035522 FANCTFCLKAKHLTRQQKR----------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000043695 FSDCVFFLKLNDLSFNERK----------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000004824 FTNCSVLVELKTLPIKEKR----------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000007671 FANCTFCLKVKHLPRQQKK----------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000001773 FTNCAFFLRVKKLTTLEKN----------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000027638 FANCVFFIKLKYSSIQKKN----------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000009821 FKNYRFYLKDDSLQYKQKK----------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000012495 FANCTFCLKVKYLPRQQKK----------------------------------------------------------------------------------------------------- 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000011840 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008035 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000012338 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250416 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010339 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000006331 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000004152 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021361 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001988 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008892 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003642 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003778 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023516 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000006847 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000027488 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000018492 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011691 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000014960 R-KKLDEQLKNQSQLIWGLKDKLKK-FCSTNDMKELLIANGQEVPSG-E--SNVVDSLADAMAFGALEACKECNG-QLVFKGD--AYYCSGDISA------------------------- T_nigroviridis_ENSTNIP00000019481 M-VLFSVLLQNQSQLIWGIKDKLNK-FCSVNDMKELLIANGQEVPSG-E--SNVLDCLADGMAFGALEPCGECRG-QLVFKGD--AYYCTGDISA------------------------- O_latipes_ENSORLP00000017176 N-KQLVENLKNQSQLIWGIKDKLRK-YCSTNDMKELLIANGQEVPSG-E--SNVVDRVADGMAFGALEACNECQG-QLVFKGD--AYYCTGDISA------------------------- D_rerio_ENSDARP00000008364 ---KLEQNLKDQSQLIWGIKDKLKK-FCSINDMKELLIANSQEVPSG-E--SNIVDRLSDCMAFGSLKPCETCKG-QLVFKSD--AYYCTGDISA------------------------- A_carolinensis_ENSACAP00000006218 Q-SKQEKLLKEQTELIWNIKDELKK-ACSTNDLKELLIANKQEVPSG-E--SAILDQVADGMAFGALLPCEECKG-QFVFKCD--AYYCTGDITA------------------------- T_rubripes_ENSTRUP00000037062 R-KKLEEQLKTQSQLIWGIKDKLNR-FCSINDMKELLIANGQDVPSG-E--SNVLDCLADGMSFGALEPCSECTG-QLVFKGD--AYYCTGNISA------------------------- D_melanogaster_FBpp0112609 EEGEKKQRLKDQNDAYFRFRDDIKN-KMKKKDIDILLKFNNQQPVTGDT--EKLFDQTADLLTFGAIESCSECNSCQFIVNKS--GYICNGNHSE------------------------- H_sapiens_ENSP00000355759 D-SKLEKALKAQNDLIWNIKDELKK-VCSTNDLKELLIFNKQQVPSG-E--SAILDRVADGMVFGALLPCEECSG-QLVFKSD--AYYCTGDVTA------------------------- M_musculus_ENSMUSP00000027777 DSSKLEKALKAQNELIWNIKDELKK-ACSTNDLKELLIFNQQQVPSG-E--SAILDRVADGMAFGALLPCKECSG-QLVFKSD--AYYCTGDVTA------------------------- P_pygmaeus_ENSPPYP00000000162 D-SKLEKALKAQNDLIWNIKDELKK-VCSTNDLKELLIFNKQQVPSG-E--SAILDRVADGMVFGALLPCEECSG-QLVFKSD--AYYCTGDVTA------------------------- C_familiaris_ENSCAFP00000023715 D-SRLEKALKAQNELIWNIKDELKK-VCSTNDLKELLIFNKQQVPSG-E--SAILDRVADGMVFGALLPCEECSG-QLVFKSD--AYYCTGDVTA------------------------- R_norvegicus_ENSRNOP00000004232 ESSKLEKALKAQNELVWNIKDELKK-ACSTNDLKELLIFNQQQVPSG-E--SAILDRVADGMAFGALLPCKECSG-QLVFKSD--AYYCTGDVTA------------------------- B_taurus_ENSBTAP00000001113 E-IKLEKALKAQNDLIWNVKDELKK-ACSTNDLKELLIFNKQEVPSG-E--SAILDRVADGMVFGALLPCEECSG-QLVFKGD--AYYCTGDVTA------------------------- E_caballus_ENSECAP00000017400 D-SKLEKALKAQNDLIWNIKDELKK-ACSTNDLKELLIFNKQQVPSG-E--SAILDRVADGMVFGALLPCEECSG-QLVFKSD--AYYCTGDVTA------------------------- M_mulatta_ENSMMUP00000028737 D-SKLEKALKAQNDLIWNIKDELKK-VCSTNDLKELLIFNKQQVPSG-E--SAILDRVADGMAFGALLPCKECSG-QLVFKSD--AYYCTGDVTA------------------------- O_anatinus_ENSOANP00000002367 E-TKQEKLLKEQTELIWNIKDELKK-ACSTNDLKELLIANKQAVPSG-E--TAILDRVADGMAFGALLPCEECKG-QFVFKSD--AYYCSGDITA------------------------- M_domestica_ENSMODP00000007535 E-TKIEKLFKTQTELIWNIKDELKK-VCSTNDLKELLIANKQEVPSG-D--SAILDRVADGMAFGALLPCEECKG-QFVFKSD--AYYCSGDITA------------------------- P_troglodytes_ENSPTRP00000003457 D-SKLEKALKAQNDLIWNIKDELKK-VCSTNDLKELLIFNKQQVPSG-E--SAILDRVADGMMFGALLPCEECSG-QLVFKSD--AYYCTGDVTA------------------------- X_tropicalis_ENSXETP00000048934 E-SKLEKLLKEQTELIWHIKDELKK-VCSTNDLKELLIANKQQVPSG-E--TNILDRVSDGMAFGALLPCEECSG-QFVFKSD--AYYCTGDLSA------------------------- A_aegypti_AAEL011815-PA E-AIDEKLYAQQQKAFFKIRDKLKGDDMKKHDLISILSRNNQSIPEG-Y--DACLERVCDILTFGALKPCPKCNG-QYVLQKS--AYMCEGNLTE------------------------- T_guttata_ENSTGUP00000004425 E-TKQQKQLKEQTELIWGIKDELRK-VCSTNDLKELLIANKQEVPSG-E--NAILDRVADGMAFGALLPCEECKG-QFVFKSD--AYYCSGDITA------------------------- G_gallus_ENSGALP00000038037 E-SKQEKQLKEQTELIWGIKDELRK-VCSTNDLKELLIANKQEVPSG-E--NAILDRVADGMAFGALLPCEECKG-QFVFKSD--AYYCSGDITA------------------------- A_gambiae_AGAP003230-PA D-ATEEKKMAEQQKAYYAIRDKLKSLGVKKSELIEILSLNKQDIPEG-N--DPVLDRVCDTLMFGALERCSKCGG-QYAFQKS--AYVCQGDLSA------------------------- C_elegans_Y71F9AL.18.1 LMEVQKKRMKKQSDLLWEYRQIFER--MPYTDKISILRENEQDIPEGHDPTAQVIERLVDNALFGCPIICQTCSNGKIVYNSSCRTYVCTGYATE------------------------- A_carolinensis_ENSACAP00000011424 E----------------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000005989 S----------------------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000000153 L----------------------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000026625 A----------------------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000014791 P----------------------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000001175 P----------------------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000000924 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015470 G----------------------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000381740 G----------------------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000025859 G----------------------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000043156 A----------------------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000016262 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000012158 G----------------------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000014771 A----------------------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000017224 T----------------------------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000015305 E-SKLEKALKAQNDLIWNIKDELKK-VCSTNDLKELLIIIKQ-VPSG-E--SAILDRVADGMVFGALLPCEECSG-QLVFKSD--AYYCTGDVTA------------------------- G_gallus_ENSGALP00000007181 E----------------------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000108098 T----------------------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000029228 G----------------------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000006583 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006181 D-SKLEKALKAQNDLIWNIKDELKK-VCSTNDLKELLIFNKQQVPSG-E--SAILDRVADGMVFGALLPCEECSG-QLVFKSD--AYYCTGDVTA------------------------- T_nigroviridis_ENSTNIP00000017650 ------------------------------------------------------------------------------------------------------------------------ C_elegans_E02H1.4 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000000045 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK1005.1a LFKILIKLSKEFNKVDEFLTQKNEKDDVLIVQAIMFDKPNVVELILDTASEMHLIHGTHNAIKENELEVVVHKTIIMYMIEMRMWELIPKVNASSEFWKSKDAKGNSVWHYAARVNSHKT H_sapiens_ENSP00000371419 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000009733 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000066130 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000011271 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000000233 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000010963 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000035522 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000043695 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000004824 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000007671 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000001773 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000027638 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000009821 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000012495 ------------------------------------------------------------------------------------------------------------------------ 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000011840 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008035 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000012338 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250416 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010339 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000006331 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000004152 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021361 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001988 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008892 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003642 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003778 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023516 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000006847 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000027488 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000018492 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011691 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000014960 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019481 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000017176 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008364 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000006218 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000037062 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0112609 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000355759 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000027777 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000000162 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000023715 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000004232 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001113 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017400 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000028737 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002367 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000007535 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000003457 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000048934 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL011815-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004425 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000038037 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP003230-PA ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y71F9AL.18.1 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011424 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005989 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000000153 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000026625 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000014791 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000001175 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000000924 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015470 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381740 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025859 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000043156 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000016262 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000012158 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014771 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000017224 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000015305 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000007181 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108098 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029228 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006583 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006181 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000017650 ------------------------------------------------------------------------------------------------------------------------ C_elegans_E02H1.4 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000000045 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK1005.1a VGLFKMIESKGVRRETNDDGRSVLHVATLACDGSADSVLEPIAWLSTRCPIDAVDKFNRTALHYAFGNENDFKEGNVPFGESDPIAVVSLLSSLIRPEQIEIADVNGNTILHLAAIKNST H_sapiens_ENSP00000371419 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000009733 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000066130 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000011271 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000000233 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000010963 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000035522 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000043695 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000004824 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000007671 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000001773 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000027638 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000009821 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000012495 ------------------------------------------------------------------------------------------------------------------------ 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000011840 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008035 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000012338 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250416 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010339 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000006331 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000004152 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021361 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001988 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008892 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003642 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003778 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023516 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000006847 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000027488 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000018492 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011691 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000014960 -------------------------------------------------------------------------WTKCVFKTPTPARRDWVTPKEFHEV-PFLKKFKFKRQDRVY---PKE T_nigroviridis_ENSTNIP00000019481 -------------------------------------------------------------------------WTKCVYKTTTPKRKDWVTPKEFHEI-SFLKKFKFKGQNRIY---PKE O_latipes_ENSORLP00000017176 -------------------------------------------------------------------------WTKCVFKTATPLRKDWIIPKEFHEV-PFLKKFKFKRQDRVY---PKE D_rerio_ENSDARP00000008364 -------------------------------------------------------------------------WTKCVFKTQTPDRKDWVTPKEFSEI-PFLKKFKFKRQDRVF---PKD A_carolinensis_ENSACAP00000006218 -------------------------------------------------------------------------WTKCVAKTQSPNRKEWIIPKAFREI-TYLKKFKFKKQERVF---PPE T_rubripes_ENSTRUP00000037062 -------------------------------------------------------------------------WTKCVNKTTTPKRKDWVTPKEFHEI-SFLKKFKFKRQNRIY---PKE D_melanogaster_FBpp0112609 -------------------------------------------------------------------------WTKCNKLLKEPTRSACIVPKELKALYNFLNTVKEIPSTRIFNNFPPN H_sapiens_ENSP00000355759 -------------------------------------------------------------------------WTKCMVKTQTPNRKEWVTPKEFREI-SYLKKLKVKKQDRIF---PPE M_musculus_ENSMUSP00000027777 -------------------------------------------------------------------------WTKCMVKTQNPSRKEWVTPKEFREI-SYLKKLKVKKQDRIF---PPE P_pygmaeus_ENSPPYP00000000162 -------------------------------------------------------------------------WTKCMVKTQTPNRKEWVTPKEFREI-SYLKKLKVKKQDRIF---PPE C_familiaris_ENSCAFP00000023715 -------------------------------------------------------------------------WTKCMVKTQTPSRKEWVTPKEFREI-SYLKKLKIKKQDRIF---PPE R_norvegicus_ENSRNOP00000004232 -------------------------------------------------------------------------WTKCMVKTQNPSRKEWVTPKEFREI-SYLKKLKIKKQDRLF---PPE B_taurus_ENSBTAP00000001113 -------------------------------------------------------------------------WTKCMVKTQTPNRKEWVTPKEFREI-SYFKKLKIKKQDRIF---PPE E_caballus_ENSECAP00000017400 -------------------------------------------------------------------------WTKCMVKTQTPNRKEWVTPKEFREI-SYLKKLKIKKQDRIF---PPE M_mulatta_ENSMMUP00000028737 -------------------------------------------------------------------------WTKCMVKTQTPNRKEWVTPKEFREI-SYLKKLKVKKQDRIF---PPE O_anatinus_ENSOANP00000002367 -------------------------------------------------------------------------WTKCVAKTQTPNRKEWTIPKEFKEI-PYLKKFKCKKQDRAF---TPE M_domestica_ENSMODP00000007535 -------------------------------------------------------------------------WTKCVAKTQTPNRKEWIIPKEFREI-SYLKKFKCKKQDRAF---PPE P_troglodytes_ENSPTRP00000003457 -------------------------------------------------------------------------WTKCMVKTQTPNRKEWVTPKEFREI-SYLKKLKVKKQDRIF---PPE X_tropicalis_ENSXETP00000048934 -------------------------------------------------------------------------WTKCVAKTQTPNRKDWVTPKEFHEV-PYLKKFKFKRQDRAF---PPC A_aegypti_AAEL011815-PA -------------------------------------------------------------------------WVKCLNTNKTPPRVPTKVPSEIKKAFPFLEKYKSVVSDRVIKYVPPS T_guttata_ENSTGUP00000004425 -------------------------------------------------------------------------WTKCVAKTQTPNRKDWVIPKEFWEI-PYLKKFKCKKQDRVF---PPD G_gallus_ENSGALP00000038037 -------------------------------------------------------------------------WTKCVAKTQTPNRKDWVIPKEFREI-PYLKKFKCKKQDRIF---PPE A_gambiae_AGAP003230-PA -------------------------------------------------------------------------WVKCMNTEKAPPRKKTKIPEELKSVYSFLKRYKSVISDRVVRYVPPS C_elegans_Y71F9AL.18.1 -------------------------------------------------------------------------YSKCTYESKNPIRTPFEVSHRLTE--------KHKLQDIVF------ A_carolinensis_ENSACAP00000011424 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005989 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000000153 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000026625 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000014791 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000001175 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000000924 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015470 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381740 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025859 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000043156 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000016262 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000012158 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014771 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000017224 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000015305 -------------------------------------------------------------------------WTKCMVKTQTPNRKEWVTPKEFREI-SYLKKLKIKKQDRIF---PPE G_gallus_ENSGALP00000007181 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108098 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029228 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006583 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006181 -------------------------------------------------------------------------WTKCMVKTQTPNRKEWVTPKEFREI-SXLKKXKVKKQDRIF---XXX T_nigroviridis_ENSTNIP00000017650 ------------------------------------------------------------------------------------------------------------------------ C_elegans_E02H1.4 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000000045 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK1005.1a ICLMTLIRKKCHVDLKNKDGNTPLALAVHHGRQSSALTLIQANADVTEKIFVPALKPTSDFDQNSSGTEAEKFWKWHGKEKKVLEDLHTTIPASVVSKGGSWEAMVYVLLDVLGQNTGSM H_sapiens_ENSP00000371419 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000009733 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000066130 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000011271 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000000233 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000010963 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000035522 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000043695 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000004824 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000007671 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000001773 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000027638 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000009821 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000012495 ------------------------------------------------------------------------------------------------------------------------ 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000011840 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008035 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000012338 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250416 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010339 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000006331 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000004152 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021361 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001988 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008892 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003642 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003778 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023516 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000006847 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000027488 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000018492 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011691 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000014960 APT-QSLPKVKAEPLAS-------ASSAPTECLPEGAPADKPLTGMKLLTVGKLTKNKEDLKVLVEEMGGKITAT-ANKASLCLSTK---KEVEKMTKKMEEAKDAGV------------ T_nigroviridis_ENSTNIP00000019481 AAP-QTVSAVKAEPLAS-------ASSVPV-GLPEGAPPDKPLTGMKLVAVGKLSKNKDDLKAAVEELGGKITGA-ANKASLCLSSK---KELEKMTKKMEEVKEAGV------------ O_latipes_ENSORLP00000017176 APT-QTLTTAKAEPLAS-------GSGALKEQLPEGAPADKPLTGMKLLAVGKLSKNKEELKAEVEEMGGKITGS-ANKASLCLSTK-------KMGKKMEEVRDAGV------------ D_rerio_ENSDARP00000008364 APPAAATPSSGSTTSAA-------TSVSSASKNLTEAPADKPLTGMKLLAVGKLSKNKDDLKKFVEDLGGKITGT-ASKAALCISSK---KEIEKMSKKMEEVRDAGV------------ A_carolinensis_ENSACAP00000006218 AAC------TNPVPPPA-------VSSTPV-IENSTTPADKPLNSMKILVLGKLSKNKDEIKSAIEELGGKVTAT-VNRANLCISSQ---KEIDKMNKKMEEVKQGQV------------ T_rubripes_ENSTRUP00000037062 APP-QTVSAVKTESLAS-------ASSVPM-SLPEGAPPDKPLTGMKLVAVGKLSKNKDDIKAAVEELGGKITGT-ANKASLCLSSK---KELEKMTKKMEEVKDAGV------------ D_melanogaster_FBpp0112609 KSTFSRSLLKT-------------NKNNDVLVRPTIPRISPPLYNLKFSIIG-LKNQHKELRKRIENLGGKFEVKISENTIAIISTE---LEIQKKSTRMKFAEELGI------------ H_sapiens_ENSP00000355759 TSA-----SVAATPPPS-------TASAPA-AVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGT-ANKASLCISTK---KEVEKMNKKMEEVKEANI------------ M_musculus_ENSMUSP00000027777 SSA-----PAPLALPLS-------VTSAPT-AVNSSAPADKPLSNMKILTLGKLSQNKDEAKAVIEKLGGKLTGS-ANKASLCISTK---KEVEKMSKKMEEVKAANV------------ P_pygmaeus_ENSPPYP00000000162 TSA-----PVAATPPPS-------TASAPA-AVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGT-ANKASLCISTK---KEVEKMNKKMEEVKEANI------------ C_familiaris_ENSCAFP00000023715 TSA-----PVAAAPPPS-------TALAPA-SVNSSTPPGKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGT-ANKASLCISTK---KEVEKMNKKMEEVREASI------------ R_norvegicus_ENSRNOP00000004232 SSA-----PAPPAPPVS-------ITSAPT-AVNSSAPADKPLSNMKILTLGKLSQNKDEAKAMIEKLGGKLTGS-ANKASLCISTK---KEVEKMSKKMEEVKAANV------------ B_taurus_ENSBTAP00000001113 SST-----PVGAAAPPS-------AASAPA-AVH-SGPPDKPLSNMKILTLGKLSQNKDEVKATIEKLGGKLTGT-ANKASLCISTKIETEEVDKMNKKMEEVKEANI------------ E_caballus_ENSECAP00000017400 TSA-----PAAAAPPPS-------AVSAPA-TVNASALPDKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGT-TSKASLCISTQ---KEVEKMNKKMEEVKEANL------------ M_mulatta_ENSMMUP00000028737 TSA-----PVVATPPPS-------TASAPA-AGNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGT-ANKASLCISTK---KEVEKMNKKMEEVKEANI------------ O_anatinus_ENSOANP00000002367 AST------PVIVPLPS-------TTPAPP-TLNSTVPADKPLSNMKILTLGKLSRNKEEMKATIEELGGKLTGS-ANKASLCISTQ---KEVEKMNKKMEEVKEAGV------------ M_domestica_ENSMODP00000007535 ANA------PPSKPLPS-------SVAAPP-TVNSSAQPDKPLSNMKILTLGKLSRNKDEMKATIEELGGKLTGT-ANKASLCISTK---KEVEKMNKKMEEVKEANV------------ P_troglodytes_ENSPTRP00000003457 TSA-----SVAATPPPS-------TASAPA-AVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGT-ANKASLCISTK---KEVEKMNKKMEEVKEANI------------ X_tropicalis_ENSXETP00000048934 AAP------TPISPPAA-------PKPAP--TVEETVPEGKPLTNAKVLVIGKLSKNKDEVKALIEGLGGKVTGS-AHKATLCISTK---KEVEKMSKKMEDVKAANV------------ A_aegypti_AAEL011815-PA LNT------TMKKV----------KKEET--QEPKIKREKPPLYELQFVILGKTATPKDELKEKILKLGGKVSSKITNTTAAIISTP---DEVERMGSRMQEAKDLQI------------ T_guttata_ENSTGUP00000004425 AAT------VNSAPPPS--------ASAPL-SETVSAPRDKPLTNMKILVVGKLSKNKEEVKSIVEDLGGKMTTT-ANKATLCISTQ---KDVEKMSKKMEEVKEAKV------------ G_gallus_ENSGALP00000038037 AAT------VNSAPPPSASAPLTETVTAPQ-GQWSSEPLEKPLTNMKILTLGKLSKNKEEVKNIVEELGGKMTTT-ANKATLCISTQ---KEVEKMSKKMEEVKDAKV------------ A_gambiae_AGAP003230-PA VNT------VMKGV----------KKEEELPSEPKIKREKPPLYDMEFVILGKTATPKDQLKLKIQKLGGKVVTKIASHTAAIISTP---EEVERLGSRMAEAKELQI------------ C_elegans_Y71F9AL.18.1 ---------------------------------------------------------------------------------------------NQMSERLYIGEEDGE------------ A_carolinensis_ENSACAP00000011424 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005989 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000000153 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000026625 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000014791 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000001175 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000000924 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015470 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381740 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025859 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000043156 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000016262 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000012158 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014771 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000017224 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000015305 SSA-----PAAAAPPPS-------TASAPA-SVTPSAPADKPLSNMKILTLGKLSRNKDEVKAAVEKLGGKVTGT-ASKASLCISTQ---KEVEKMNKKMEEVREANV------------ G_gallus_ENSGALP00000007181 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108098 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029228 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006583 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006181 XXX-----XXXXXXXXX-------XXXXXX-XXXXXXSAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXX---XXXXXXXXKMEEVKEANI------------ T_nigroviridis_ENSTNIP00000017650 ------------------------------------------------------------------------------------------------------------------------ C_elegans_E02H1.4 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000000045 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK1005.1a AQLTDAALRRGQLNLANQLLKSIEALIDGAVLNSSYDLLDTFAEKCFGALTSEETIEKTVLNRIILTRGLGLKQPETMKIIRTALQNGNWNLLNFLKSEMGTAWKNQKIETPTENPIRSL H_sapiens_ENSP00000371419 -----------------------------------------------------------KLQTDIKENGGKFSFSLNPQCTHIILD----NADVLSQYQLNSIQKNHV------------ P_troglodytes_ENSPTRP00000009733 -----------------------------------------------------------KLQTDIKENGGKFSFSLNPQCTHIILD----NADVLSQYQLNSIQKNHV------------ M_musculus_ENSMUSP00000066130 -----------------------------------------------------------KLQTDIKENGGKFSFLLNPQCTHVIVD----SADVLSRCHLNSIQKNDV------------ G_aculeatus_ENSGACP00000011271 -----------------------------------------------------------KLRSAVTDNGGTICYVVNKQCSLVVTG----NLADLSASRLRGIRRHGT------------ T_rubripes_ENSTRUP00000000233 -----------------------------------------------------------SLKSAITDNGGNICFVVNKQCSLILAS----DVSSLSTNRLRSIQKYQT------------ C_familiaris_ENSCAFP00000010963 -----------------------------------------------------------KLQNDIKENGGSFSFLLNPQCTHTILD----NAAVLTQYQLKCIQKNQI------------ B_taurus_ENSBTAP00000035522 -----------------------------------------------------------KLQTDIKENGGNFSFLLNAQCTHVILD----NADVLSQYQLKSIQKNHI------------ X_tropicalis_ENSXETP00000043695 -----------------------------------------------------------ALKLTVTSNGGVISFVLNQKCTHVVVN----TIGCLSSSQQKNVQKHQI------------ T_nigroviridis_ENSTNIP00000004824 -----------------------------------------------------------SLKAAITENGGTICFVVNKQCSLILTS----DASSLSPNRLRSIRKHQT------------ E_caballus_ENSECAP00000007671 -----------------------------------------------------------KLQTDIKENGGKFSFLLNPQCTHIILD----SADVLSQYQLNSLQKNHI------------ A_carolinensis_ENSACAP00000001773 -----------------------------------------------------------RLKKCIQENGGHIKFVLNQECTHVVTG----SDDELSSTHLKAIKKYQL------------ G_gallus_ENSGALP00000027638 -----------------------------------------------------------SLKACIEENGGAIDFVLNNKCTHVLVD----NANVLSHHNLKITQKYQL------------ M_domestica_ENSMODP00000009821 -----------------------------------------------------------FLRTHIKKNNGNVSSVLTHKCTHVILD----NDAVLSPGELSTAQKYHI------------ O_cuniculus_ENSOCUP00000012495 -----------------------------------------------------------KLQSDIKENGGKFSLWLNPQXXXXXXX----XXXXXXXXXXXXXXXXXX------------ 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000011840 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008035 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000012338 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250416 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010339 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000006331 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000004152 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021361 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001988 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008892 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003642 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003778 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023516 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000006847 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000027488 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000018492 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011691 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000014960 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019481 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000017176 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008364 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000006218 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000037062 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0112609 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000355759 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000027777 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000000162 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000023715 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000004232 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001113 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017400 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000028737 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002367 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000007535 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000003457 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000048934 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL011815-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004425 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000038037 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP003230-PA ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y71F9AL.18.1 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011424 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005989 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000000153 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000026625 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000014791 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000001175 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000000924 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015470 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381740 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025859 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000043156 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000016262 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000012158 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014771 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000017224 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000015305 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000007181 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108098 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029228 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006583 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006181 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000017650 ------------------------------------------------------------------------------------------------------------------------ C_elegans_E02H1.4 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000000045 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK1005.1a LIYMNEKSVSSEAIGFLEELRQMRGVNIDALCQLEIPGKFKKILDYGLIPPISFAVLQENPNMIRALRNAGASLKTQDDYGRTPLMYAIMTNNRSVVDAIVGDGKLAVVLHKQKAVATGP H_sapiens_ENSP00000371419 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000009733 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000066130 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000011271 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000000233 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000010963 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000035522 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000043695 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000004824 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000007671 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000001773 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000027638 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000009821 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000012495 ------------------------------------------------------------------------------------------------------------------------ 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 ----------------------------------------------------------------RKGPMAGGK-DADRTKDNR--------------DSVKTLLLKGKAPVDPECAAKLG R_norvegicus_ENSRNOP00000011840 ----------------------------------------------------------------KKGPAAGGE-DTDRTKGKQ--------------DSVKTLLVKGRAPVDPECTSKVG C_familiaris_ENSCAFP00000008035 -------------------------------------------------------------QGVKRGPLTAGGAGNGSTEDKP--------------ESVKTLLLKGRAPVDPECAAKVG B_taurus_ENSBTAP00000012338 ---------------------------------------------------------------LKKEPVAEGKTDSDRTEDKQ--------------ESVKTLLLKGKAPVDPECTTKVG H_sapiens_ENSP00000250416 -------------------------------------------------------------QESKKMPVAGGKANKDRTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVG P_troglodytes_ENSPTRP00000010339 -------------------------------------------------------------QESKKMPVAGGKANKDRTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVG P_pygmaeus_ENSPPYP00000006331 -------------------------------------------------------------QESKKMPVAGGKSNKDRTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVG E_caballus_ENSECAP00000004152 -------------------------------------------------------------------------------------------------ESVKTLLLKGKVPVDPECTAKVG M_mulatta_ENSMMUP00000021361 ------------------------------------------------------------------MPVTGGNANEDRTEDKQDGTPGRSWASKRVSESVKALLLKGKVPVDPECTAKVG O_cuniculus_ENSOCUP00000001988 -------------------------------------------------------------LEMKKEPSAGKKADKEGTEDKQGGKARAS----NFSESVKALLIKGKAPVDPECTAKVG M_domestica_ENSMODP00000008892 ------------------------------------------------------------------------------------------------SVSVKTLLLKGKTPVDPECTIKVG A_carolinensis_ENSACAP00000008175 -------------------------------------------------------------------------------------------------EAVKTLIVKGKAPVDPECTAKLG X_tropicalis_ENSXETP00000003642 ------------------------------------------------------------------GSKSVIN-VEDESEENK--------------EQVRTLVMKGKAPVDPECSTKLG O_latipes_ENSORLP00000003778 ---------------------------------------------------------------------------------------------------VKTVVMKGRAPVDPECNAKLG G_aculeatus_ENSGACP00000023516 -------------------------------------------------------------SQTKTEE------MPKEEIKSE--------------EVVRTVIMKGKAPVDPECKAKLG T_nigroviridis_ENSTNIP00000006847 -------------------------------------------------------------SQTKCEE------MPKEEIKSK--------------EVVKTLVLKGKAPVDSECKAKLG T_rubripes_ENSTRUP00000027488 ----------------------------------------------------------------------------------K--------------EVVKTVVLKGKAPVDSECKAKLR C_intestinalis_ENSCINP00000018492 ---------------------------------------------------------NVAVVKTTALKTKKIKKEVKVVTNDQ--------------VVTKVIKFKGKVPVDDYCVECKD C_intestinalis_ENSCINP00000011691 -----------------------------------------------------------PDKEVSVKKSKDNEEDASTSVKEE--------------IKEKVVVFTGSIPLDEECTLDPK G_aculeatus_ENSGACP00000014960 --------------------------RVVSEDFLADIKSSGKALQELVSLHAISPWGAEVKVEAQA-SSAASKS-GPLATKSTGKVKVKEEEGGSKS-KKMKLTVKGGAAVDPDSGLE-N T_nigroviridis_ENSTNIP00000019481 --------------------------RVVSEDFLTDIKSSGKALQELVSLHAISPWGAEVKVETQA-QPMASKS-GAMAAKSTG--RVKEQEGGGKS-KKMKLTVKGGAAVDPDSGLE-N O_latipes_ENSORLP00000017176 --------------------------RVVSEDFLLDIKSSGKALQELVSLHAISTWGVEVKVEPQA-PAAASKS-GALAAKSSG--KVKEEEGGSKS-KKMKLTVKGGAAVDPDSGLE-N D_rerio_ENSDARP00000008364 --------------------------RVVADDFLTDIKESGKALQELISLHAISPWGAEVKVEAPA-AAAATKSTGAHSSKSTG--KVKEEEGGSKS-KKMKLTVKGGAAVDPDSGLE-N A_carolinensis_ENSACAP00000006218 --------------------------RVVSEEFLQDAKASSKGLQELLSLHALSPWGTEVKQEHKE-VFVAEKSSGHSNMKSTG--KNKEEQGTSKSEKKMKLTVKGGAAVDPDSGLE-D T_rubripes_ENSTRUP00000037062 --------------------------RVVSEDFLTDIKSSGKDLQELVSLHTISPWGAEVKVESQA-QPVASKS-GAMAAKSTG--KVKEEEGGSKS-KKMKLTVKGGAAVDPDSGLE-N D_melanogaster_FBpp0112609 --------------------------HIVPIEFLDFVEADTEGAIKYINSTCICSWGTDPKSRIPK-ETTKSLNSNSIYTKSMP--------------VSRTFKVKDGLAVDPDSGLE-D H_sapiens_ENSP00000355759 --------------------------RVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKG--QVK-EEGINKSEKRMKLTLKGGAAVDPDSGLE-H M_musculus_ENSMUSP00000027777 --------------------------RVVCEDFLQDVSASTKSLQELLSAHSLSSWGAEVKAEPGEVVAPKGKS-AAPSKKSKG--AVK-EEGVNKSEKRMKLTLKGGAAVDPDSGLE-H P_pygmaeus_ENSPPYP00000000162 --------------------------RVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKG--QVK-EEGINKSEKRMKLTLKGGAAVDPDSGLE-H C_familiaris_ENSCAFP00000023715 --------------------------RVVSEDFLRDVSDSTRSLQDLLSAHVLAPWGAEVKAEPAEPAAPKAKSGAALSKKSKG--PVK-EEGVNKSEKRMKLTLKGGAAVDPDSGLE-H R_norvegicus_ENSRNOP00000004232 --------------------------RVVCEDFLQDVSASAKSLQELLSAHSLSSWGAEVKVEPGEVVVPKGKS-AAPSKKSKG--AVK-EEGVNKSEKRMKLTLKGGAAVDPDSGLE-H B_taurus_ENSBTAP00000001113 --------------------------RVVSEDFLQDISASTKSLQELLSTHLLSPWGAEVKVEPVEAVAPKGKSGAAPSKKSKG--PVK-EEGTNKSEKRMKLTLKGGAAVDPDSGLE-H E_caballus_ENSECAP00000017400 --------------------------RVVSEDFLQDVSTSTKSLQELLSAHILSPWGAEVKAEPVEVAAPRGKSGAALPKKSKG--PVK-EEGSNKSEKRMKLTLKGGAAVDPDSGLE-H M_mulatta_ENSMMUP00000028737 --------------------------RVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPKGKSGAALSKKSKG--QVK-EEGINKSEKRMKLTLKGGAAVDPDSGLE-H O_anatinus_ENSOANP00000002367 --------------------------RVVSEEFLKDVAASGKRLQELLTLHALSPWGAEVKQEHPE-VPLSGKSGGPVSTKSAG--KIKEEEGASKSEKKMKLTVKGGAAVDPDSGLE-D M_domestica_ENSMODP00000007535 --------------------------RVVSEDFLKDISASGKSLQELLSLHILSSWGTEVKQEPVE-VKAGGKS-GPSSKKSKG--QVKEEEGTSKSEKKMKLTLKGGAAVDPDSGLE-D P_troglodytes_ENSPTRP00000003457 --------------------------RVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKG--QVK-EEGINKSEKRMKLTLKGGAAVDPDSGLE-H X_tropicalis_ENSXETP00000048934 --------------------------RVVSDDFLKEVE-SGKSVQELLSQYGISSWGAEVKQEAVQ-PTEKQPSSAPAAGKSSG--KVKEEKGNNKSEKKMKLTVKGGAAIDPDSGLE-D A_aegypti_AAEL011815-PA --------------------------QVVPEDFLE--DAKSGGAISYITSKSICDWGSDPHSRIPQDEE-KSKSKKSIYTKSVP--------------SKMTLKLKGGLAVDPDSGLD-E T_guttata_ENSTGUP00000004425 --------------------------RVVSEAFLQDVKSSSKDFQELVSLHALSPWGAEVKMEHEE-MAVDGKSSKPPSTKSAG--KVKEEQGPSKSEKKMKLTVKGGAAVDPDSGLE-D G_gallus_ENSGALP00000038037 --------------------------RVVSEEFLKDVKSSSKGFQELLSLHAISPWGAEVKTEHQE-VAVDGKCSKPANMKSAG--KVKEEQGPSKSEKKMKLTVKGGAAVDPDSGLE-D A_gambiae_AGAP003230-PA --------------------------QVVPEDFLE--DVVGGGAISFITSRSICDWGSDPLKRIPTEEESKSRTKKSIYEKSVP--------------AKMKLQVKSGLVVDPDSGLA-D C_elegans_Y71F9AL.18.1 --------------------------SVVKIDKRK------------------SKGGTRGEQFIYAAEAFDSTNNVPIKVGDL--------------TSTNTHIIKKGTVVDAKFALA-D A_carolinensis_ENSACAP00000011424 -------------------------------------------------------------------PEEDSFHSTLVALKAAP------------------KE-KLKSKIDSACWLSSS T_rubripes_ENSTRUP00000005989 -------------------------------------------------------------------EPKDAFTSAKEALLAAG------------------PQVKGRRKVDEHCQVSAS X_tropicalis_ENSXETP00000000153 -------------------------------------------------------------------KAPDRFQSAVQALKAAS------------------GK-KGKAKIDSSCHLSSY D_rerio_ENSDARP00000026625 -------------------------------------------------------------------PPKDKFTSAKEALKATG------------------SQVKGTRNPDSVCHLSN- M_domestica_ENSMODP00000014791 -------------------------------------------------------------------ATEDNFHLAKEALKAAP------------------KE-ARKAQVDSLCPLSNN G_aculeatus_ENSGACP00000001175 -------------------------------------------------------------------EPKDAFTSAKEALLAAG------------------PQVKGKRNVDEHCSLPSS O_latipes_ENSORLP00000000924 -------------------------------------------------------------------EPKDAFTSAKEALLAAG------------------AQPKGRRAVDEQCPLAST P_pygmaeus_ENSPPYP00000015470 -------------------------------------------------------------------REEDPFRSAAEALKAIP------------------AE-KRIIHVDPTCPLSSN H_sapiens_ENSP00000381740 -------------------------------------------------------------------REEDPFRSTAEALKAIP------------------AE-KRIIRVDPTCPLSSN P_troglodytes_ENSPTRP00000025859 -------------------------------------------------------------------REEDPFRSTAEALKAIP------------------AE-KRIICMDPTCPLSSN B_taurus_ENSBTAP00000043156 -------------------------------------------------------------------EEEDSFRSTAEALKAAP------------------TE-KCIARVDPSCPLSCN E_caballus_ENSECAP00000016262 -------------------------------------------------------------------TEDDNFRSTAEALRAAP------------------TE-KCIVRVDPACPLSGS G_gorilla_ENSGGOP00000012158 -------------------------------------------------------------------REEDPFRSTAEALKAIP------------------AE-KRIIHVDPTCPLSSN C_familiaris_ENSCAFP00000014771 -------------------------------------------------------------------EEEDSFRSTAEALRAAP------------------TE-KHVVRVDPACPLSHN R_norvegicus_ENSRNOP00000017224 -------------------------------------------------------------------GEEGSFRSTAEALRAAP------------------AG-NRIIRVDPPCPLSGN O_cuniculus_ENSOCUP00000015305 --------------------------RVVAEDFLQDVSSSAKSLQELLSAHILSPWGAEVKAEPVEAVAPKPKSGAAVAKKSKG--PV--EEGMNKSEKRMKLTLKGGAAVDPDSXXX-X G_gallus_ENSGALP00000007181 -------------------------------------------------------------------EEEDAWSSALNALKTAP------------------RE-KPPATIDGQCPLSAG M_musculus_ENSMUSP00000108098 -------------------------------------------------------------------EEEDSFRSTAEALRAAP------------------AD-NRVIRVDPSCPFSRN M_mulatta_ENSMMUP00000029228 -------------------------------------------------------------------REEDPFRSTAEALKAMP------------------AE-KHIIRVDPTCPLSSN T_guttata_ENSTGUP00000006583 --------------------------------------------------------------------EDDTWSSTLATLKTAP------------------KE-KRPATIDGLCPPSRA G_gorilla_ENSGGOP00000006181 --------------------------RVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKG--QXK-EEGINKSEKRMKLTLKGGAAVDPDSGLE-H T_nigroviridis_ENSTNIP00000017650 -------------------------------------------------------------------EPKDAFTSTKEALLAAG------------------PQVKGRRKVDEHCSLSAS C_elegans_E02H1.4 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000000045 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK1005.1a RCVAVPMRFGATSRAFIPAAAFASVPARVESDEEEEDNSGSESGEDGAASENKSEHGSENGESGNGSDDEDDDDDDSSPPPAKKSRIAKEAAGPSTGPKRKKLVITDPSLFSARDHKENN H_sapiens_ENSP00000371419 --------------------------HIANPDFIWKSIREKRLLDVKNYDPYKPLDI-TPPPDQKASSSE---VKTEGLC-PDSATEEEDTVEL-----------TEFGMQNVEIPHLPQ P_troglodytes_ENSPTRP00000009733 --------------------------HIANPDFIWKSIREKRLLDVKNYDPYKPLDI-TPPPDQKASSPE---VKTEGLC-PDSATEEEDTVEL-----------TEFGMQNVEIPHLPQ M_musculus_ENSMUSP00000066130 --------------------------QIANPAFIQDSVRQRRLLDVRNYDPLSPAPA-APPAERSRSE-----VQSEYLP-SDNTPEKENT-EV-----------TEVSAENVEIPPFLQ G_aculeatus_ENSGACP00000011271 --------------------------PVVGVDYVYGCLERGFLLPADDYKLEASSPP-PACPAAAAATPRHG-ILLMVDNHPRSTTRD-----------------RIYTETDPDLPKYPL T_rubripes_ENSTRUP00000000233 --------------------------PVVGVDYVSSCLQSGVLLPVDGYRLDASSPPVTQTPVKADAEPRRDPVTPVVGRRPAPTTWEQSGDVL-----------GKFSGDDSDLPPFPD C_familiaris_ENSCAFP00000010963 --------------------------HIINPDFIWDSIKEKRLLDIMNYDPNKAVDI-IPPPCQKACSSE---VTTDDPS-LDNSMEKENIVEF-----------TEFY-KNVEIPHFPQ B_taurus_ENSBTAP00000035522 --------------------------LIANPDFVWESIKERRLLDTKIYGPSESLDI-TSASSEEWSSPK---MEMNDSSFLDSSTEKENTVEL-----------TKFYAEGVEIPHFPQ X_tropicalis_ENSXETP00000043695 --------------------------PIVDSQFIWQCLEKKCLIQDYQYPTAGVKPS-EKEPEGWQGSTE-----------PSTSSKRQNHMAH-----------PLLNATHVAVPIIFH T_nigroviridis_ENSTNIP00000004824 --------------------------PVVGVEYVSSCLERGALLPLDGYRLDA--PPTPAPPTKSSG--GNPPLCPNLAK-LEPDFWDLLLC-------------RVYGEDDSDLPPFPD E_caballus_ENSECAP00000007671 --------------------------HIANPEFIWESVKERTLLDVKNYDPNKSVGL-TPPPCQKASSLG---VKADDLS-LDNSTEKENVVEV-----------TKFYTDNVEILDFPQ A_carolinensis_ENSACAP00000001773 --------------------------PVVGPDFIWNSVKERRLLQINNNEPPKTLPS----VTGKESSNG---LYVKGPT-DSSPVWSVSFCFL-----------RWFSNNDEDVPYFPE G_gallus_ENSGALP00000027638 --------------------------PVLYADFVWKSVENGKLLVTDAFEKSSAMNT------GSKADIN---TSISEKK-GNRVLQSMCFDYMDNMDLFPLKQITEVSVRTVQKPYLEN M_domestica_ENSMODP00000009821 --------------------------SIANIDFLWECLKQGELLSVENYKCNASSEV-TPPPFKRPSNVE------EDLH-STTENNKEIT-EH-----------KKFCTEDDNIPHVPQ O_cuniculus_ENSOCUP00000012495 --------------------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXX---XXXXXXX-XXXXXXXXXXXXX-----------XXFHAENVD---FPQ 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 1800 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 K--AHVYCE--------------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000011840 K--AHVYCE--------------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000008035 K--AHVYCE--------------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000012338 K--AHVYFE--------------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000250416 K--AHVYCE--------------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000010339 K--AHVYCE--------------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000006331 K--AHVYCE--------------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000004152 K--AHVYCE--------------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000021361 K--AHVYCE--------------------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000001988 K--XXXXXX--------------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000008892 K--AHVYCE--------------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000008175 K--AHVYCE--------------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000003642 R--AHVFCE--------------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000003778 K--AHVYSE--------------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000023516 K--AHVYSE--------------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000006847 K--AHVYSE--------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000027488 K--AHVYTE--------------------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000018492 G--YHVFVC--------------------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000011691 Q--YHVYTE--------------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000014960 S--AHVLEQ--------------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000019481 S--AHVLEQ--------------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000017176 S--AHVLEQ--------------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000008364 C--AHVLEQ--------------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000006218 S--AHVFEK--------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000037062 S--AHVLEQ--------------------------------------------------------------------------------------------------------------- D_melanogaster_FBpp0112609 I--AHVYVD--------------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000355759 S--AHVLEK--------------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000027777 S--AHVLEK--------------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000000162 S--AHVLEK--------------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000023715 S--AHVLEK--------------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000004232 S--AHVLEK--------------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000001113 N--AHVLEK--------------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000017400 S--AHVLEK--------------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000028737 S--AHVLEK--------------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000002367 S--AHVFEK--------------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000007535 S--AHVLEK--------------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000003457 S--AHVLEK--------------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000048934 S--CHVLEK--------------------------------------------------------------------------------------------------------------- A_aegypti_AAEL011815-PA V--AHVYKK--------------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000004425 S--AHVFEK--------------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000038037 S--AHVFEK--------------------------------------------------------------------------------------------------------------- A_gambiae_AGAP003230-PA K--AHVYKF--------------------------------------------------------------------------------------------------------------- C_elegans_Y71F9AL.18.1 R--CHVFKN--------------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000011424 AGDAKIYED--------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000005989 ---AEVHED--------------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000000153 GD-YEVYED--------------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000026625 ---AEVHED--------------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000014791 PD-VQVYED--------------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000001175 ---NEVHED--------------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000000924 ---GEVYED--------------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000015470 PG-TQVYED--------------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000381740 PG-TQVYED--------------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000025859 PG-TQVYED--------------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000043156 PG-TQVSCN--------------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000016262 PG-TQVHED--------------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000012158 PG-TQVYED--------------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000014771 PQ-TQVHED--------------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000017224 PG-IQVHED--------------------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000015305 X--XXXXXX--------------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000007181 PD-AKVYED--------------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000108098 PG-IQVHED--------------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000029228 PE-TQVHED--------------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000006583 LG-ARVYED--------------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000006181 S--AHVLEK--------------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000017650 ---GEVHED--------------------------------------------------------------------------------------------------------------- C_elegans_E02H1.4 ---SIINDE--------------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000000045 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK1005.1a P--LHYFIEPLAWENVELLGDLAAANKTAIVQCLIDKRSPNPIELAAMKMNRRMKSEMLKIVKNAAFPRPIKETKLTLQQVHIEPLSDVDEDAAKFLAKWVEEKDKKKTSEAPKPHKSST H_sapiens_ENSP00000371419 D--FEVAK---------------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000009733 D--FEVAK---------------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000066130 D--FEVVK---------------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000011271 N--FQVAK---------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000000233 H--FQVAK---------------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000010963 D--FEVAK---------------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000035522 D--FEVAK---------------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000043695 N--SEHEA---------------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000004824 R--FQVAK---------------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000007671 D--FEVAK---------------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000001773 D--FEIAK---------------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000027638 D--FEVAK---------------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000009821 D--FEVAK---------------------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000012495 D--FEVAK---------------------------------------------------------------------------------------------------------------- 1810 1820 1830 1840 1850 1860 1870 1880 1890 1900 1910 1920 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 ------------GDDVYDVMLNQTNLQFNN---NKYYLIQLLEDDAQ-RN-FSVWMRWGR---V--GKTGQHSLVTCSGDLNKAKEIFQKKFLDKTKNNW--EDRE-NFEKVPG-KYDML R_norvegicus_ENSRNOP00000011840 ------------GDDVYDVMLNQTNLQFNN---NKYYLIQLLEDDAQ-QN-FSVWMRWGR---V--GKTGQHSLVACSGDLNKAKEIFQKKFLDKTKNNW--EDRE-NFEKVPG-KYDML C_familiaris_ENSCAFP00000008035 ------------GSDVYDVMLNQTNLQFNN---NKYYLIQLLEDDAQ-RH-FSVWMRWGR---V--GKMGQHSLVACSGDLNKAKEIFQKKFLDKTKNNW--EDRE-KFEKVPG-KYDML B_taurus_ENSBTAP00000012338 ------------GNDVYDVMLNQTNLQFNN---NKYYLIQLLEDDAQ-RN-FSVWMRWGR---V--GKTGQHSLVACSGDLNKAKEIFQKKFLDKTKNNW--EDRE-KFEKVPG-KYDML H_sapiens_ENSP00000250416 ------------GNDVYDVMLNQTNLQFNN---NKYYLIQLLEDDAQ-RN-FSVWMRWGR---V--GKMGQHSLVACSGNLNKAKEIFQKKFLDKTKNNW--EDRE-KFEKVPG-KYDML P_troglodytes_ENSPTRP00000010339 ------------GNDVYDVMLNQTNLQFNN---NKYYLIQLLEDDAQ-RN-FSVWMRWGR---V--GKMGQHSLVACSGNLNKAKEIFQKKFLDKTKNNW--EDRE-KFEKVPG-KYDML P_pygmaeus_ENSPPYP00000006331 ------------GNDVYDVMLNQTNLQFNN---NKYYLIQLLEDDAQ-RN-FSVWMRWGR---V--GKMGQHSLVACSGNLNKAKEIFQKKFLDKTKNNW--EDRE-KFEKVPG-KYDML E_caballus_ENSECAP00000004152 ------------GNDVYDAMLNQTNLQFNN---NKYYVIQLLEDDAQ-RN-FSVWMRWGR---V--GKVGQHSLVACSGDLNKAKEIFQKKFLDKTKNNW--EGRE-KFEKVPG-KYDML M_mulatta_ENSMMUP00000021361 ------------GSNVYDVMLNQTNLQFNN---NKYYLIQLLEDDAQ-RN-FSVWMRWGR---V--GKMGQHSLVACSGNLNKAKEIFEKKFLDKTKNNW--EDRE-KFEKVPG-KYDML O_cuniculus_ENSOCUP00000001988 ------------XXXXXXXXXXXTNLQFNN---NKYYLIQLLEDDAQ-RN-FSVWMRWGR---X--XKMGQHSLVACSGDLSKAKEIFQKKFFDKTKNNW--EDRE-KFEKVPG-KYDML M_domestica_ENSMODP00000008892 ------------GDDVYDVMLNQTNLQFNN---NKYYIIQLLEDDGQ-RT-FSVWTRWGR---V--GKVGQHNLVTCSGDLNKAKEIFQKKFFDKTKNSW--EDRG-SFKKVPG-KYDML A_carolinensis_ENSACAP00000008175 ------------GDDVYDVMLNQTNVQFNN---NKYYLIQLLEDDAS-RN-YSVWMRWGR---V--GKPGQHSLVSFAGALAKAKDLFTKKFLDKTKNEW--TKRQ-NFTKVPG-KYDLL X_tropicalis_ENSXETP00000003642 ------------GDDVYDVMLNQTNLQFNN---NKYYLIQLLEDDGV-RN-FSVWMRWGR---V--GKVGQNSLVCCGGDLQKAKDIFQKKFLDKTKNLW--TERA-QFEKCPG-KYDML O_latipes_ENSORLP00000003778 ------------GSIVYDVMLNQTNLQFNN---NKFYLIQLLQDDSS-KS-FSVWMRWGR---G--QFTLLNSLTACGGDLLKAKDIFKKKFFDKTRNEW--EQRG-SFVKVAG-KYDMV G_aculeatus_ENSGACP00000023516 ------------GNNVYDVMLNQTNLQFNN---NKYYLIQLLQDDSS-KA-YSVWSRWGR---V--GKVGQSNLAPCGGDLLKAKDVFKKKFLDKTKNDW--EHRA-SFEKVPG-KYDMV T_nigroviridis_ENSTNIP00000006847 ------------GNDVYDVMLNQTNLQFNN---NKYYLMQLLEDDGS-KL-YSVWFRWGRGHLV--GKVGQNSLTECTTDLNKAKDIFKKKFFDKTKNEW--ERKD-QFEKVAG-KYDMV T_rubripes_ENSTRUP00000027488 ------------GNNVYDVMLNQTNLQFNN---NKYYLMQLLEDDKS-KF-YSVWFRWGR---V--GKVGQNNLIECGADLNQAKDIFKKKFFDKTKNEW--EHRE-NFMKVAG-KYDIV C_intestinalis_ENSCINP00000018492 ------------GDTVYNAMLNQTNIGQNN---NKYYLLQVLKSNIG-AE-FCVWFRWGR---V--GKVAGTNLQKV--TCEKAVQLFEKKFKDKTSNFW--ENRG-HFEKVHG-KYDLL C_intestinalis_ENSCINP00000011691 ------------QDLVFNAMLNQTNIGSNN---NKYYVIQLLKNNKT-SD-FFIWLRWGR---V--GKVAGKTLEAV--GLEQGKATFQKKFREKTGNYF--HVFNLPFVKKKG-KYDLL G_aculeatus_ENSGACP00000014960 ------------GGRMYSATLGLVDIVRGT---NSYYKLQLLEDDVQ-KR-YWVFRSWGR---V--GTTIGGNKLDKVYDKNSALDNFLGVYKEKTGNDW----SSSNFTKYPN-KFYPL T_nigroviridis_ENSTNIP00000019481 ------------GGKMYSATLGLVDIVRGT---NSYYKLQLLEDDVQ-KR-YWVFRSWGR---V--GTTIGGNKLDKFSDRNSAMDNFLTVYKEKTGNDW----SSSNFTKYPN-KFYPL O_latipes_ENSORLP00000017176 ------------SGKMYSATLGLVDIVRGT---NSYYKLQLLEDDLQ-KR-YWVFRSWGR---V--GTTIGGNKLDKFHDKNSALDNFLSVYKEKTGNEW----GSSNFIKYPT-KFYPL D_rerio_ENSDARP00000008364 ------------NGKIYSATLGLVDIVRGT---NSYYKLQLLEDDVQ-KR-YWVFRSWGR---V--GTTIGGNKLDKFYDKNSAMDNFCGVYEEKTGNAW----ASSNFTKYPN-KFYPL A_carolinensis_ENSACAP00000006218 ------------GAKIFSATLGLVDIVRGT---NSYYKLQLLEDDRE-LR-YWVFRSWGR---V--GTSIGSNKLEQMPSKEEAIEHFLNLYEEKTGNSW----HSKNFTKYPK-KFYPL T_rubripes_ENSTRUP00000037062 ------------GGKMYSATLGLVDIVRGT---NSYYKLQLLEDDVQ-KR-YWVFRSWGR---V--GTTIGGNKLDKFSDKNSAMNNFLTVYKEKTGNEW----SCSNFTKYPN-KFYPL D_melanogaster_FBpp0112609 ------------SNNKYSVVLGLTDIQRNK---NSYYKVQLLKADKK-EK-YWIFRSWGR---I--GTNIGNSKLEEFDTSESAKRNFKEIYADKTGNEY--EQRD-NFVKRTG-RMYPI H_sapiens_ENSP00000355759 ------------GGKVFSATLGLVDIVKGT---NSYYKLQLLEDDKE-NR-YWIFRSWGR---V--GTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAW----HSKNFTKYPK-KFYPL M_musculus_ENSMUSP00000027777 ------------GGKVFSATLGLVDIVKGT---NSYYKLQLLEDDKE-SR-YWIFRSWGR---V--GTVIGSNKLEQMPSKEDAVEHFMKLYEEKTGNAW----HSKNFTKYPK-KFYPL P_pygmaeus_ENSPPYP00000000162 ------------GGKVFSATLGLVDIVKGT---NSYYKLQLLEDDKE-NR-YWIFRSWGR---V--GTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAW----HSKNFTKYPK-KFYPL C_familiaris_ENSCAFP00000023715 ------------GGKVFSATLGLVDIVKGT---NSYYKLQLLEDDKE-SR-YWIFRSWGR---V--GTVIGSNKLEQVPSKEEAIEHFMKLYEEKTGNAW----HAKNFTKHPK-KFYPL R_norvegicus_ENSRNOP00000004232 ------------GGKVFSATLGLVDIVKGT---NSYYKLQLLESDKE-SR-YWIFRSWGR---V--GTVIGSNKLEQMPSKEDAVEHFMKLYEEKTGNAW----HSKNFTKYPK-KFYPL B_taurus_ENSBTAP00000001113 ------------GGKVFSATLGLVDIVKGT---NSYYKLQLLEDDKE-SR-YWIFRSWGR---V--GTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAW----HSKNFTKHPK-KFYPL E_caballus_ENSECAP00000017400 ------------GGKVFSATLGLVDIVKGT---NSYYKLQLLEDDKE-SR-YWIFRSWGR---V--GTVIGSNKREQMPSKEDAIEHFMKLYEEKTGNAW----HSKNFTKYPK-KFYPL M_mulatta_ENSMMUP00000028737 ------------GGKVFSATLGLVDIVKGT---NSYYKLQLLEDDKE-SR-YWIFRSWGR---V--GTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAW----HSKNFTKYPK-KFYPL O_anatinus_ENSOANP00000002367 ------------GGKIFSATLGLVDIVRGT---NSYYKLQLLEDDREISR-YWVFRSWGR---V--GTEIGSNKLEQMPSKEDAIEHFLNLYEEKTGNSW----HSKNFTKYPK-KFYPL M_domestica_ENSMODP00000007535 ------------NGKIFSATLGLVDIVKGT---NSYYKLQLLEDDRE-IR-YWIFRSWGR---V--GTVIGSNKLEQMSSREDAIDHFCKLYEEKTGNSW----HSTNFTKYPK-KFYPL P_troglodytes_ENSPTRP00000003457 ------------GGKVFSATLGLVDIVKGT---NSYYKLQLLEDDKE-NR-YWIFRSWGR---V--GTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAW----HSKNFTKYPK-KFYPL X_tropicalis_ENSXETP00000048934 ------------GGKIFSATLGLVDITRGT---NSYYKLQLIEHDRN-SR-YWVFRSWGR---V--GTVIGSNKLEEMSSKEDAIDHFLNLYQEKTGNAW----HSPNFTKYPN-KFYPL A_aegypti_AAEL011815-PA ------------HKEVYNCVLNKVDIQTDK---NSYFKMQVLVADKG-NK-FWFFRSWGR---I--GTTIGGNKLESCSTLLDAMNLFEHHFQDKTGNSWDEYRH-GAFHKHPG-AYYPV T_guttata_ENSTGUP00000004425 ------------GGKIFSATLGLVDIVKGT---NSYYKLQLLEDDRE-NR-YWVFRSWGR---V--GTVIGSNKLEKMPSKEDAIEHFLNLYEEKTGNSW----HSKNFTKYPK-KFYPL G_gallus_ENSGALP00000038037 ------------GGKIFSATLGLVDIVKGT---NSYYKLQLLEDDRE-SR-YWVFRSWGR---V--GTVIGSNKLEQMPSKEDAVEHFLNLYEEKTGNPL----SSKKSGQHPT-----L A_gambiae_AGAP003230-PA ------------HDVIYNCVLNKVDIQKDK---NSFYKMQVLEGDTK-KK-YWLFRAWGR---I--GTTIGGNKVENFSSADSAMSAFEDLFLEKTGNDW--VRHDSVYSKMPG-AFYPI C_elegans_Y71F9AL.18.1 ----------EIDGSLYQATLSFTDLTQNK---NSYYKIQLLKDDQR-EN-YYVFRSWGR---V--GTEVGGNKHESYSNSNEAILKFQDVFHEKTKNDW--IYRK-HFRKMPG-MFSYV A_carolinensis_ENSACAP00000011424 ----------------YDCMLNQTNIGHNN---NKFYIIQLIEENG---K-YSCWNRWGR---V--GEA-GQSKLNSFPSLEAAKKDFEKKFRDKTKNNW--ADRD-NFVCHDG-KYTLI T_rubripes_ENSTRUP00000005989 ----------------YDCMLNQTNIGQNN---NKFYVIQVIKDNN---R-FYSWNRWGR---V--GEV-GQSKLSPFDKLEKAVKDFEKKFKDKTKNSW--SDRS-NFVSYAG-KYTMI X_tropicalis_ENSXETP00000000153 ----------------YDCMLNQTNIGSNN---NKFYVIQLITKKN---E-YYCWNRWGR---V--GEV-GQSKLSPFPKLENAQKDFEKKFKDKTKNSW--SERE-NFTPHPG-KYTII D_rerio_ENSDARP00000026625 ----------------YDCMLNQTNIGNNN---NKFYVIQVLVSGG---K-YYCWTRWGR---V--GES-GQNALAGPSAADAAIKSFEKKFKEKTKNNW--SDRE-NFVSHSG-KYTLI M_domestica_ENSMODP00000014791 ----------------YDCTLNQTNIGNNN---NKFYLIQLLDEGG---Q-YQCWNRWGR---V--GEV-GQSKLKPFSSLDDAKKDFEKKFQEKTKNRW--ADRD-NFVAHQG-KYTLI G_aculeatus_ENSGACP00000001175 ----------------YDCMLNQTNIGNNN---NKFYVIQVIKDKS---S-YYTWTRWGR---V--GEV-GQSKLNTFNESEKAVKDFEKKFKDKTKNNW--SDRS-NFVSHPG-KYTLI O_latipes_ENSORLP00000000924 ----------------YGCMLNQTNIGHNN---NKFYVIQVVQENK---R-FYSWNRWGR---VIQGEV-GQNKLNSFDTPEKAVKDFEKKFKDKTKNDW--SNRS-NFVTHPG-KYTLI P_pygmaeus_ENSPPYP00000015470 ----------------YDCTLNQTNIGNNN---NKFYIIQLLQDSD---R-FTCWNRWGR---V--GEV-GQSKINHFTRLEDAKKDFEKKFREKTKNNW--AERD-RFVSHPG-KYTLI H_sapiens_ENSP00000381740 ----------------YNCTLNQTNIENNN---NKFYIIQLLQDSN---RFFTCWNHWGR---V--GEV-GQSKINHFTRLEDAKKDFEKKFREKTKNNW--AERD-HFVSHPG-KYTLI P_troglodytes_ENSPTRP00000025859 ----------------YDCTLNQTNIENNN---NKFYIIQLLQDSN---R-FTCWNRWGR---V--GEV-GQSKINHFTRLEDAKKDFEKKFREKTKNNW--AERD-HFVSHPG-KYTLI B_taurus_ENSBTAP00000043156 ----------------YNCTLNQTNI-ERN---NKFYIIQLLKDAD---C-FFCWTRWGR---V--GEV-GQSKLSRFESLEDAKKSFEKKFRDKTKNSW--AERD-HFVAQPG-KYTLT E_caballus_ENSECAP00000016262 ----------------YNCTLNQTNIGNNN---NKFYIIQLLEAGD---R-FVCWNRWGR---V--GEV-GQSKLNYFVLLEDAKKDFEKKFRDKTKNSW--AERD-RFVAHPG-KYTLI G_gorilla_ENSGGOP00000012158 ----------------YDCTLNQTNIENNN---NKFYIIQLLQDSD---R-FTCWNRWAR---V--GEV-GQSKINHFTRLEDAKKDFEKKFREKTKNNW--AERD-HFVSHPG-KYTLI C_familiaris_ENSCAFP00000014771 ----------------YACTLNQTNIGRNN---NKFYIIQLLEEGD---R-FACWNRWGR---V--GEV-GQSKLSYFVLLEDAKKDFEKKFQDKTKNRW--VERD-HFVAHPG-KYTLI R_norvegicus_ENSRNOP00000017224 ----------------YDCTLNQTNIGNNN---NKFYIIQLLEEGG---R-FSCWNRWGR---V--GEV-GQSKMNHFGCLEDAKKDFKKKFWEKTKNKW--EERD-HFVAHPN-KYTLI O_cuniculus_ENSOCUP00000015305 ------------XXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXX-XX-YWIFRSWGR---V--GTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAW----XXXXXXXXXX-XXXXX G_gallus_ENSGALP00000007181 ----------------YDCTLNQTNISANN---NKFYIIQLIEHGG---T-YSTWNRWGR---V--GEV-GQSKLLPFTSLEAAKKDFEKKFWEKTKNRW--AARD-NFVAQPG-KYTLI M_musculus_ENSMUSP00000108098 ----------------YDCTLNQTNIGNNN---NKFYIIQLLEEGS---R-FFCWNRWGR---V--GEV-GQSKMNHFTCLEDAKKDFKKKFWEKTKNKW--EERD-RFVAQPN-KYTLI M_mulatta_ENSMMUP00000029228 ----------------YDCTLNQTNIGNNN---NKFYIMQLLQDGQ---H-FTCWNRWGR---V--GEV-GQSKINHFTRLEDAKKDFEKKFREKTKNKW--AERD-RFVAHPG-KYTLI T_guttata_ENSTGUP00000006583 ----------------YDCTLNQTNIKANN---NKFYIIQLLEHNG---A-YSVWSHWGR---V--GEV-GQSKLMPCASLEAAKKDFEKKFREKTKNSW--ATRE-NFIAQPG-KYTLI G_gorilla_ENSGGOP00000006181 ------------GGKVFSATLGLVDIVKGT---NSYYKLQLLEDDKE-NX-XXXXXXXXX---X--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXX-XXXXX T_nigroviridis_ENSTNIP00000017650 ----------------YDCMLNQTNIGHNN---NKFYVIQVIQANN---R-FFSWNRWGR---V--GEV-GQSKLSPFDKLENAIKDFEKKFKDKTKNSW--SDRS-NFVSHPG-KYTMI C_elegans_E02H1.4 ------------NGRGYKVHLCKTNIAQNN---NKFYDMELLDEGG---D-FIVKLINGR---I--GYR-GVTQLKDFDDLDRAKKFFESKFYEKTHLHW--EERD--DEPVPN-KYAVV T_nigroviridis_ENSTNIP00000000045 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK1005.1a YSTNGLVSFCDETQQYFDVLMNKTDLMYGRCGFHNFYRMQIIKRRDA-EL-FILFTNWGR---I--GSGMGEFQTTPFNSLELAAKEFKSIFKSKSGNEW--APLA-NFRDMPK-KYRLV H_sapiens_ENSP00000371419 ----------------YNTLEKVGMEGGQE---AVVVELQCSRDSRD-CP-FLISSHFLLDD-----GMETRRQFAIKKTSEDASEYFENYIEELKKQGF--LLRE-HFTPEAT-QLASE P_troglodytes_ENSPTRP00000009733 ----------------YNTLEKVGMEGGQE---AVVVELQCSRDSRD-CP-FLISSHFLLDD-----GMETRRQFAIKKTSEDASEYYENYIEELKKQGF--LLRE-HFTPEAT-QLASE M_musculus_ENSMUSP00000066130 ----------------YNILEKV---GGPE---TVVVELQSSQDPES-CP-FVITAHFLLAD------QKTRRESTGKQTSEGAIEYYESYVEDLKRQGF--LLQE-HFTAEAT-QLASE G_aculeatus_ENSGACP00000011271 ----------------YCVFEKQG--NGGA---WCVLELQSHAGEGA-RR-YRVVRYWKDDVSA--EAAAVRDALVFLSASEDAVEVYEAQRESLQAAGL--QPRT-STPPQAP-HLGSA T_rubripes_ENSTRUP00000000233 ----------------YSIFEKP---NSSS---WCVLELQSLREEGG-RT-YRVARYWKDEAGA--EEAAAKDTLVFLATSEEALEVYTYLRETLIQTGL--QQRR-SGSAQAQ-DLGSA C_familiaris_ENSCAFP00000010963 ----------------YNTLEKIGAKGGKE---VAVVELQSCQDPED-PA-FLISTHFLLAN-----GHKTRK-FSVQKTSADASEYYENYIEELKKQGF--LLRE-HFTPEAT-QLASE B_taurus_ENSBTAP00000035522 ----------------YNILEKVVTEGGKE---TAVVELQCLQGPGD-RG-FLICTHFLLAT-----GTQTRRQSSVKKTSADASEYYENYIEELKKQGF--LLRE-HFTPEAT-QLASE X_tropicalis_ENSXETP00000043695 ----------------SFHLEPLHPGGNMS---CSILSLTQSWWLSQ-VA-FTGKFSFLIVDIL--FSVQPDSSYMFKHTAEAACNKYEKCTEDLEKEGF--KRAK-RIPPKVA-LLTSE T_nigroviridis_ENSTNIP00000004824 ----------------YSIYEKS---RSSS---GWLLELQSLREEGG-RR-LLIAK----ARLL--EEAAVKEALVFPSTSEEALEVYECLRTSLLQSGL--RQRR-SLPAQAR-ELGSA E_caballus_ENSECAP00000007671 ----------------YNSLEKPGTEGAQE---LAVVELQCSQDPGD-RA-FLISAHFLMAD-----GTETRRQLSVKKTSAEASEYYENFIEELKKQGF--LLRE-HFTPEAT-QLASE A_carolinensis_ENSACAP00000001773 ----------------YNLLEKVAAHG--E---YVLVELQCFQQQCD-YP-FRIYRHCSVRD-----GKQVEKQFIPTKTSEKARRNYELCIENLKKEGF--ELRT-DFPNEAE-YLASW G_gallus_ENSGALP00000027638 ----------------YNVLEKINSKGSKD---FVVIELHCSQEQYE-FL-FRLCAHFSASN-----GTKKDKQFIINKTADEIRENYDILVANLKSQDF--LLRE-TFPPEAE-CLAST M_domestica_ENSMODP00000009821 ----------------YSILEK--SERDKE---IVVVELQCFQDHPE-FS-FLVSANFLLAG-----GVKTKRHLSRKNTSEEASEYFENYIEELKKQGF--LPSE-NFPPEANLKLASE O_cuniculus_ENSOCUP00000012495 ----------------YNTLEKXXXXXXXX---XXXXXXXXXXXXXX-XX-XXXXXXXXXXX-----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXX-XXXXXXX-XXXXX 1930 1940 1950 1960 1970 1980 1990 2000 2010 2020 2030 2040 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 QMDYA-A--STQDESKTKEEET------------------LKPE--------SQLDLRVQELLKLICNVQTMEEMMIEMKYDTK-RAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGR-- R_norvegicus_ENSRNOP00000011840 QMDYA-A--STEDENKTKQEET------------------SKPE--------SQLDLRVQELLKLICNVQTMEEMMIEMKYDTK-RAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGR-- C_familiaris_ENSCAFP00000008035 EMDYA-T--NTQSEEETKK-ESLKLP--------------FKPE--------SQLDLRVQELIELICNVQAMEETMVEMKYDTK-KAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGR-- B_taurus_ENSBTAP00000012338 QMDYA-S--NTQNEEETKKEESLKSR--------------LKLE--------SQLDLRVQELIKLICNVQAMEEMMVEMKYDTK-KAPLGKLTVAQIKAGYQSLKKIEDCIR-GQHGR-- H_sapiens_ENSP00000250416 QMDYA-T--NTQDEEETKKEESLKSP--------------LKPE--------SQLDLRVQELIKLICNVQAMEEMMMEMKYNTK-KAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGR-- P_troglodytes_ENSPTRP00000010339 QMDYA-T--NTQDEEETKKEESLKSP--------------LKPE--------SQLDLRVQELIKLICNVQAMEEMMMEMKYNTK-KAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGR-- P_pygmaeus_ENSPPYP00000006331 QMDYA-T--NTQDEEETKKEESLKSP--------------LKPE--------SQLDLRVQELIKLICNVQAMEEMMMEMKYNTK-KAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGR-- E_caballus_ENSECAP00000004152 QMDYS-T--TTQSEEETKKEESLKSS--------------LKPE--------SQLDLRVQELIKLICNVQAMEEMMVEMKYDTK-KAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGR-- M_mulatta_ENSMMUP00000021361 QMDYA-T--NTQDEEETKKEESLKSP--------------LKPE--------SQLDLRVQELIKLICNVQAMEEMMMEMKYNTK-KAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGR-- O_cuniculus_ENSOCUP00000001988 QMDYA-A--NTQGEDETKKEEALKS---------------LKPE--------SRLDIRVQELIQLICNVQAMEETMIEMKYDTK-KAPLGKLTMAQIKAGYQSLKKIEDCIRAGQHGR-- M_domestica_ENSMODP00000008892 QLDYT-S--NIEGEESKDEALVPISP--------------PKLE--------SQLERPVQELIELICNIQNMEEMMVEMKYDIK-KAPLGKLTVAQIKAGYESLKKIEDCIRSGQSGR-- A_carolinensis_ENSACAP00000008175 HLDYE-A--NDTSEEEAASEKT-NSC--------------PTPV--------SRLEPRVQALVQLICNIRTMEEMVMEMKYDTK-KAPLGKLTAEQIRAGYQSLQKVEACLKRKQTGR-- X_tropicalis_ENSXETP00000003642 QMDYN-A--TEQEEERAVKEESLADL--------------PKLE--------CQLDLSIQELIQLICNLKAMEETVLEMKFDTK-KAPLGKLTVDQIRAGYCSLQRIENCIKKQKFGR-- O_latipes_ENSORLP00000003778 FMDYS-T--NEKVETKTLVD---AAT--------------NKRS--------CKLDPKVQSLLELICDLKAMEECVLEMKFDTR-KAPLGKLTSEQIRAGYAALKKIEECLKRKGSSR-- G_aculeatus_ENSGACP00000023516 FMDYS-T--SKKEENQTAVD---AAP--------------KKRT--------CKLDVKVQSLLELICDIKAMEECVLEMKFDTR-KAPLGKLTTEQIRAGYAALKNIEECLKKKGNGR-- T_nigroviridis_ENSTNIP00000006847 FMDYS-T--EEKEKKHSVVE-----T--------------KKQA--------SKLDVKIQSLLELICDLKAMEECVLEMKFDTR-KAPLGKLTPEQIRAGYVALRKIEDCLKKKASHR-- T_rubripes_ENSTRUP00000027488 LMDYS-A--DEKEKKNAMVD-----T--------------KKQA--------SMLDVKIQELLELICDLKAMEECVLEMKFDTQ-KAPLGKLTSEQIRAGYVALRKIEDCLKKKSSRN-- C_intestinalis_ENSCINP00000018492 EMDFG-N--EDKETAKPN-----VDA--------------KKIK--------SKLNNRVKEVMELIFNMNEFEESVKEMKFDVK-KAPLGKLTEKQIKSGYESLKYIEECLQRNKAGR-- C_intestinalis_ENSCINP00000011691 EMDYG-E--DKKTDTNKKD---TKNK--------------VKAE--------SVLHKSLQDVMTLIFDITEWEESVKEMKFDIK-KSPLGKLTKKQITAGYEALKAVETCITHDKVDKQ- G_aculeatus_ENSGACP00000014960 EIDYG-Q--DEEAVKR------LTAS--------------SGTK--------SKLAKPVQELIKMIFDVESMKKAMVEFEIDLQ-KMPLGKLSKRQIQSAYSLLTEVQQAVSDTQSEA-- T_nigroviridis_ENSTNIP00000019481 EIDYG-Q--DEEAVKK------LTAT--------------AGTK--------SKLAKPVQELIKMIFDVESMKKAMVEFEIDLQ-KMPLGKLSKRQIQSAYALLTEVHQAVSDSLPEA-- O_latipes_ENSORLP00000017176 EIDYGQQ--DEEAVKR------LTAS--------------AGTK--------SKLPKPVQELIKMIFDVESMKKAMVEFEIDLQ-KMPLGKLSKRQIQSAYALLTEVQQAVSDCVPEA-- D_rerio_ENSDARP00000008364 EIDYG-Q--DEEAVKK------LTQS--------------AGAK--------SQLEKPVQDLIRMIFDVESMKKAMVEFEIDLQ-KMPLGKLSKRQIQSAYSLLSEVQQAVADSSSES-- A_carolinensis_ENSACAP00000006218 EIDYG-Q--DEEAVKK------LTVS--------------AGTK--------SKLPKPVQDLIKMIFDVESMKKAMVEFEIDLQ-KMPLGKLSKRQIQSAYSILNEVQQAVSDGGTES-- T_rubripes_ENSTRUP00000037062 EIDYG-Q--DEEAVKR------LTAT--------------AGTK--------SKLAKPIQELIKMIFDVESMKKAMVEFEIDLQ-KMPLGKLSKRQIQSAYALLTEVHQAVSDSLPEA-- D_melanogaster_FBpp0112609 EIQYD-D--DQKLVKH--------ES--------------HFFT--------SKLEISVQNLIKLIFDIDSMNKTLMEFHIDMD-KMPLGKLSAHQIQSAYRVVKEIYNVLECGSNTA-- H_sapiens_ENSP00000355759 EIDYG-Q--DEEAVKK------LTVN--------------PGTK--------SKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQ-KMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDS-- M_musculus_ENSMUSP00000027777 EIDYG-Q--DEEAVKK------LTVK--------------PGTK--------SKLPKPVQELVGMIFDVESMKKALVEYEIDLQ-KMPLGKLSRRQIQAAYSILSEVQQAVSQGSSES-- P_pygmaeus_ENSPPYP00000000162 EIDYG-Q--DEEAVKK------LTVN--------------PGTK--------SKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQ-KMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDS-- C_familiaris_ENSCAFP00000023715 EIDYG-Q--DEEAVKK------LTVK--------------PGTK--------SKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQ-KMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDS-- R_norvegicus_ENSRNOP00000004232 EIDYG-Q--DEEAVKK------LAVK--------------PGTK--------SKLPKPVQELVGMIFDVESMKKALVEYEIDLQ-KMPLGKLSRRQIQAAYSILSEVQQAVSQGSSES-- B_taurus_ENSBTAP00000001113 EIDYG-Q--DEEAVKK------LTVN--------------PGTK--------SKLPKPVQNLIKMIFDVESMKKAMVEYEIDLQ-KMPLGKLSKRQIQAAYSILSEVQQALSQGSSDS-- E_caballus_ENSECAP00000017400 EIDYG-Q--DEEAVKK------LTLN--------------PGTK--------SKLPKPVQELIKMIFDVESMKKAMVEYEIDLQ-KMPLGKLSKRQIQAAYSILSEVQQALSQGSGDS-- M_mulatta_ENSMMUP00000028737 EIDYG-Q--DEEAVKK------LTVN--------------PGTK--------SKLPKPVQDLIKLIFDVESMKKAMVEYEIDLQ-KMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDS-- O_anatinus_ENSOANP00000002367 EIDYG-Q--DEEAVKK------LTVS--------------AGTK--------SKLPKPVQNLIKMIFDVESMKKAMVEFEIDLQ-KMPLGKLSKRQIQNAYSILNEVQQAVSEGGSDS-- M_domestica_ENSMODP00000007535 EIDYG-Q--DEEAVKK------LTVS--------------AGTK--------SKLPIPVQNLIKMIFDVESMKKAMVEFEIDLQ-KMPLGKLSKRQIQNAYSILSEVQQVVSQGGSDS-- P_troglodytes_ENSPTRP00000003457 EIDYG-Q--DEEAVKK------LTVN--------------PGTK--------SKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQ-KMPLGKLSKRQIQTAYSILSEVQQAVSQGSSDS-- X_tropicalis_ENSXETP00000048934 EIDYG-Q--EEDVVKK------LSVG--------------AGTK--------SKLAQPVQELIKLIFDVESMKKAMVEFEIDLQ-KMPLGKLSKRQIQSAYSILNQVQQAVSESSSEA-- A_aegypti_AAEL011815-PA DIDYN-----DEETKT------LAEN--------------NDIK--------SKLEPAVQDLVRMLFDVDTMKKVMLEFELDME-KMPLGKLSQKQLQSAMKVLSEISELIVNGGSNS-- T_guttata_ENSTGUP00000004425 EIDYG-Q--DEEAVRK------LTVG--------------AGTK--------SKLAKPIQDLIKMIFDVESMKKAMVEFEIDLQ-KMPLGKLSKRQIQSAYSILNEVQQAVSDNGSES-- G_gallus_ENSGALP00000038037 PMNFT-L--DEEAVRK------LTVS--------------AGTK--------SKLAKPIQDLIKMIFDVESMKKAMVEFEIDLQ-KMPLGKLSKRQIQSAYSILNEVQQAVSDGGSES-- A_gambiae_AGAP003230-PA EIDYS-----ETKTKR------LAEN--------------SGIK--------SKLAPAVQDLVRMLFDVDAMNRVMMEFELDME-KMPLGKLSKRQLQSAMKVLSEISTLIGSGGSNA-- C_elegans_Y71F9AL.18.1 ETDYS-E--FAQITDT-------EIT--------------PGSK--------TLLPKSVKEVVMSIFDVENMKSALKSFEMDVN-KMPLGRLSHNQINLAFEVLNDISDLLVKLPIDAS- A_carolinensis_ENSACAP00000011424 EVQQG-D-EEDQEVIVKGTFCQVV-----LK---PAKQ--KIRP--------CTLDKPTQELVSLIFSNDMFKDAMQTMNIDVK-KMPLGKLSKQQIAKGFEALEAIETTLQEQSYSQK- T_rubripes_ENSTRUP00000005989 EVDGE-Q--DAEVKVDE------MDG-KDVK----VSK--NVLP--------CTLDGATKNLIKLIFSNDMFKEAMECMNLDIK-KMPLGKLSKMQIAKGFEVLEEIEAAMKQRRGSSR- X_tropicalis_ENSXETP00000000153 EVEHD-D--DNGSGEAT------VKA-DTVD---GTVQ--KVRP--------CSLDKPTQDLISLIFSTDMFKEAMQTMNLDIK-KMPLGKLSKAQIAKGFEALDELQAALDRKANKG-- D_rerio_ENSDARP00000026625 EVDGD-Q--DAEVKVDS------VDG-GAVK----VKREQNVLP--------CTLDAETQRLMRFIFDNDMFKEAMTSMDLDIK-KMPLGKLSKQQIAKGFEALEEIEAAIKKSERSK-- M_domestica_ENSMODP00000014791 EVQAD-DGQEGQEGTVKVRPSQVVDG---VQ---AVEQ--IVKP--------CTLDPATQKLVELIFSSDMFKDAMKCMNLDIR-KMPLGKLSKKQIAKGFEALEALEDALQKGAQEGQ- G_aculeatus_ENSGACP00000001175 EVDGE-Q--DAEVKVDT------VDG-KNVQ----VAK--NVQD--------CTLDGATKSLIKLIFSNDMFKEAMECMNLDIK-KMPLGKLSKIQIAKGFDVLEEIEAAMNKKGGNKKK O_latipes_ENSORLP00000000924 EVEGE-Q--DAEVKVDS------VDG-KAVK----VPK--NTLP--------CTLDEATQKLITLIFSNDMFKEAMECMDLDIK-KMPLGKLSKVQIAKGFEVLEEIEAALNKPNQRHL- P_pygmaeus_ENSPPYP00000015470 EVQAE-D--EAQEAVVK------VDG-GPVR---TVAK--RVQP--------CSLDPATQKLITNIFSKEMFKNTMALMDLDVK-KMPLGKLSKQQIARGFEALEALEEALKGPTDGGQ- H_sapiens_ENSP00000381740 EVQAE-D--EAQEAVVK------VDR-GPVR---TVTK--RVQP--------CSLDPATQKLITNIFSKEMFKNTMALMDLDVK-KMPLGKLSKQQIARGFEALEALEEALKGPTDGGQ- P_troglodytes_ENSPTRP00000025859 EVQAE-D--EAQEAVVK------VDR-GPVR---TVTK--RVQP--------CSLDPATQKLITNIFSKEMFKNTMALMDLDVK-KMPLGKLSKQQIARGFEALEALEEALKGPTDGGQ- B_taurus_ENSBTAP00000043156 EVQRE-D--EAQEVVEK------VDG-GPVK---AVVQ--WVRP--------CSLDAATQKLITNIFSKDVFQNAMALMNLDVK-KMPLGKLSKQQIA-GFEALEEVEAALKAPADSGR- E_caballus_ENSECAP00000016262 EVQGE-E--ETQEAVVK------VDG-GPLR---TVVQ--QVQP--------CSLDTATQKLITNIFSKDMFNNAMALMNLDVK-KMPLGKLSKQQIARGFEALEALEVALKTPSDGGL- G_gorilla_ENSGGOP00000012158 EVQAE-D--EAQEAVVK------VDG-GPVR---TVTK--RVQP--------CSLDPAXQKLITNIFSKEMFKNTMALMDLDVK-KMPLGKLSKQQIARGFEALEALEEALKGRTDGGQ- C_familiaris_ENSCAFP00000014771 EVQGE-D--EAQEAVVK------VDG-GSVR---NIVQ--RVRP--------CSLDAPTQKLITNIFSKDMFKNAMTLMNLDVK-KMPLGKLSKQQIARGFEALEALELALKAPTDGGP- R_norvegicus_ENSRNOP00000017224 EVQGE-A--ETQEAVVKALSPQ-VD--GPVR---TV-----FKP--------CSLDPATQKLITNIFSKEMFKNAMTLMNLDVK-KMPLGKLSKQQIARGFEALEALEEAMKNPTGDGQ- O_cuniculus_ENSOCUP00000015305 XXXXX-X--DEEAVKK------LTVS--------------PGTK--------SKLPKPVQELIKMIFDVESMKKAMVEYEIDLQ-KMPLGKLSKRQIQAAYSILNEVQQXXXXXXXXX-- G_gallus_ENSGALP00000007181 EVQPG-A---GQEVALR------VDGAGDEK---VSKR--RVLP--------CALDETTQKLVALIFSSDMFRHAMQAMNIDVK-KMPLGKLSKQQIARGFEALEELEAALGEQPRSMS- M_musculus_ENSMUSP00000108098 EVQGE-A--ESQEAVVKALSPQ-VYS-GPVR---TV-----VKP--------CSLDPATQNLITNIFSKEMFKNAMTLMNLDVK-KMPLGKLTKQQIARGFEALEALEEAMKNPTGDGQ- M_mulatta_ENSMMUP00000029228 EVQGE-D--EAQEAVVK------VDG-GPVR---TVAK--RVQP--------CSLDPATQKLVTNIFSKEMFKNTMALMDLDVK-KMPLGKLSKQQIARGFEALEALEEALKGPTDGGQ- T_guttata_ENSTGUP00000006583 EVQPG-A---GQEVVTM------VGW-SSLHSWPTEHQ--DIQQ--------GPQDGTSFEGGSGCLLKHLAGRDLGLMEI-----WPSGWHWPWKV----EAAPAHCSAAPGPGSPHR- G_gorilla_ENSGGOP00000006181 XXXXX-X--XXXXXXX------XXXX--------------XXXX--------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXAVSQGSSDS-- T_nigroviridis_ENSTNIP00000017650 EVDGE-Q--DAEVKVDD------VDG-KVVK----VSK--NVLP--------CTLNDATKNLVQLIFSTDMFKEAMECMNLDIK-KMPLGKLSKMQIAKGFEVLEEIEAAMNQRRGGAR- C_elegans_E02H1.4 ELATN-ARQTEKEVKKEEPEPEPKVDEKNTRGRKKRGIVKEKKEIKKEEEPVEEVNEKLKELMKCICDEDVHLGLLKQLKFNEAFGRPIDCLSLAQLTTGYEILSKIEESIGGKSARRST T_nigroviridis_ENSTNIP00000000045 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK1005.1a ETDST-P--TSLAEIEL-----------------------TWKK--------NTEKDPIRRMIADISDAKTLKTYASQVQMYGGSSQPFGRFTKENIEKAKLVLDKLEKNANRIKQMVEA H_sapiens_ENSP00000371419 QLQAL-----------------LLEE--------------VMNS--------STLSQEVSDLVEMIW-----AEALGHLEHML--LKPVNRISLNDVSKAEGILLLVKAALKNGETAE-- P_troglodytes_ENSPTRP00000009733 QLQAL-----------------LLEE--------------VMNS--------STLSQEVSDLVEMIW-----AEALGHLEHML--LKPVNRISLNDVSKAEGILLLVKAALKNGETAE-- M_musculus_ENSMUSP00000066130 KLQAL-----------------LLEE--------------VISS--------GALSQEVSDLLEVIW-----TEALGHLENTL--LKPVNSMSLNDVSKAEGILLLVKTALKNGDSPG-- G_aculeatus_ENSGACP00000011271 PLQQL-----------------LLEE--------------RLNT--------GSLSQEVGVFVELLW-----TEALGRLGNIL--RVPIHKLSLNDVSRAEGLLLQAHSKLRGADG-S-- T_rubripes_ENSTRUP00000000233 PLRQL-----------------LLEE--------------KLNA--------GTLTQEVGAFVELLW-----AEATGRLGDIL--AVPVEKLSLNDVSRAEGLLLQAHRKLRETEL-K-- C_familiaris_ENSCAFP00000010963 KLQAL-----------------LLEE--------------VINA--------SALSKEVSDLVEMVW-----AEALGCLGRLL--LKPVNRISLNDVSKAEGVLLLVKAALKNGETEE-- B_taurus_ENSBTAP00000035522 KLQAL-----------------LLEE--------------VINS--------NALSPEVSGLVEMLW-----AEALGRLEDTL--LRPVGMMSLNDVSKAEGILLLVKEAMRNGETQE-- X_tropicalis_ENSXETP00000043695 ALQKV-----------------LLEE--------------AINA--------TKLSPDVGYFVESVW-----IEALGHLDNIL--SRPVNSISLNDVSKAEGVLLQVRKALDTRTEPG-- T_nigroviridis_ENSTNIP00000004824 PLQQL-----------------LLEE--------------RLNT--------GTLTQEVGAFVELLW-----TEATGRLGDIL--TAPVEKLSLNDVSVAPRLQTDFLRSPDPGSQVS-- E_caballus_ENSECAP00000007671 KLQAL-----------------LLEE--------------VINS--------STLSQEVSHLVEMIW-----AEALGHLEHTL--LQPVNRISLNDVSKAEGILLLVKTALENGETEE-- A_carolinensis_ENSACAP00000001773 KLQEI-----------------LVSE--------------AISS--------STLSEGVAKFVELIW-----IEALGVLDLVL--AKPVTSISLNDVSKAEGVLLRTKKALNDMKSPS-- G_gallus_ENSGALP00000027638 KLQKL-----------------LLEE--------------SINS--------SAICQEVSDFVELIW-----AEALGHLDSLL--LESVNNISLNDVSKAEGILLQVKNALNEGANET-- M_domestica_ENSMODP00000009821 KLQAL-----------------LLED--------------VLGR--------DNVSEDVSTLVELIW-----MEALGHLKNIL--LRPENSISLNDVSKAEGILLQVKAALNKGATTE-- O_cuniculus_ENSOCUP00000012495 XXXXL-----------------LLEE--------------VLGA--------STLSTEVSDLVELLW-----AEALGHLEHTL--LKPVNKISLNDVSKAEGILLLAKSALKNGETAE-- 2050 2060 2070 2080 2090 2100 2110 2120 2130 2140 2150 2160 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 A-----------------LVEACNEFYTRIPH-DFGLSIPPVIRTEKELSDKVKLLE----ALG-DIEIALKLVKSE--R-Q--G-------LEHPLDQHYRNLHCALRPLDHESNEF-K R_norvegicus_ENSRNOP00000011840 A-----------------LVEACNEFYTRIPH-DFGLSIPPVIRTEKELSDKVKLLE----ALG-DIEIALKLVKSE--R-Q--G-------LEHPLDQHYRNLRCALRPLDHESHEF-K C_familiaris_ENSCAFP00000008035 A-----------------LVEACNEFYTRIPH-DFGLRTPPLIRTEKELSDKVQLLE----ALG-DIEIAIKLVKTA--L-Q--S-------PEHPLDQHYRKLHCALHPLDHESHEF-K B_taurus_ENSBTAP00000012338 A-----------------LMEACNEFYTRIPH-DFGLRTPPLIRTEKELSDKVQLLE----ALG-DIEIAIKLVKTE--L-Q--S-------PEHPLDQQYRKLRCALHPLHHESYEF-K H_sapiens_ENSP00000250416 A-----------------LMEACNEFYTRIPH-DFGLRTPPLIRTQKELSEKIQLLE----ALG-DIEIAIKLVKTE--L-Q--S-------PEHPLDQHYRNLHCALRPLDHESYEF-K P_troglodytes_ENSPTRP00000010339 A-----------------LMEACNEFYTRIPH-DFGLRTPPLIRTQKELSEKIQLLE----ALG-DIEIAIKLVKTE--L-Q--S-------PEHPLDQHYRNLHCALRPLDHESYEF-K P_pygmaeus_ENSPPYP00000006331 A-----------------LTEACNEFYTRIPH-DFGLRTPPLIRTQKELSEKIQLLE----ALG-DIEIAIKLVKTE--L-Q--S-------PEHPLDQHYRNLHCALHPVDHESYEF-K E_caballus_ENSECAP00000004152 A-----------------LTEACNEFYTRIPH-DFGLRTPPLIRTEKELSEKVQLLE----ALG-DIEIAMKLVKTE--L-Q--S-------PEHPLDQHYRRLHCALRPLDRDSYEF-K M_mulatta_ENSMMUP00000021361 P-----------------LMEACNEFYTRIPH-DFGLRTPPLIRTQKELSEKIQLLE----ALG-DIEIAIKLVKTE--L-Q--S-------PEHPLDQHYRNLHCALRPLDHESYEF-K O_cuniculus_ENSOCUP00000001988 V-----------------LLEACNEFYTRIPH-DFGLRTPPLIRTEKELSDKVQLLE----TLG-DIEIAIKLVKTE--L-Q--S-------PEHPLDQHYRNLHCSLHPLDHESHEF-K M_domestica_ENSMODP00000008892 I-----------------LVEACNEFYTRIPH-DFGLRTPPLIRTEQELTDKIQLLE----ALG-DIEIAIKLVKTE--L-R--N-------PEHPLDQHYRNLHCVLRPLDHSCHEF-K A_carolinensis_ENSACAP00000008175 T-----------------LLEACNEFYTRIPH-DFGLKTPPLIHTEKELKEKVQLLE----ALS-EIRIGIKAVRSE--Q-L--D-------QEHPLDRSYRGLNCDLQPLEKESPDF-Q X_tropicalis_ENSXETP00000003642 D-----------------LLEACNEFYTRIPH-DFGLRTPPLIRTLEDLTVKVRLLE----ALG-DIQIAVKLASMD--L-N--S-------LEHPIDRQYRQLNCSIQPLDKTSSTF-Q O_latipes_ENSORLP00000003778 D-----------------LLEACNQFYTRIPH-DFGLRPPPVIHTDAELKEKISLLE----ALS-DIQIAVKMVQSS--A-D--S-------EEHPLDRHYHSLKCNLQPLDSTSSEF-K G_aculeatus_ENSGACP00000023516 D-----------------LLEACNQFYTRIPH-DFGLKTPPIIHTEDELKEKISLLE----ALS-DIQIAVKMVQSS--K-D--G-------DEHPLDRQYCSLQCQMQPLDSGSHEY-K T_nigroviridis_ENSTNIP00000006847 Q-----------------LLEACNQFYTRIPH-DFGLKTPPIIQTEQELKDKIALLE----ALS-DIQIAVKMVKAN--E-D--S-------DENPLDRQYRALQCRLQPLDAGCHEY-E T_rubripes_ENSTRUP00000027488 E-----------------LLKACNQFYTRIPH-NFGLKTPPIIHTEQELKEKIALLE----ALS-DIQIAVKMVKSN--E-D--G-------DENPLDRQYRSLHCSLQPLDSSSHEY-R C_intestinalis_ENSCINP00000018492 D-----------------LVEACSEFYTRIPH-DFGMKCPPLVRSAHELKEKLELLS----ALS-DIQIAIKIMDEA--E-G--S-----GLKENPFDLRYKSLQCEMKPLPKTSKNF-K C_intestinalis_ENSCINP00000011691 E-----------------LIEACSQFYTRIPH-DFGMKAPPLIETTDQLKEKLELLE----ALN-EIQVAISIVEDE--N-D--E------NDTNPIDLNYKSLNCDLTPLDRSDDQF-K G_aculeatus_ENSGACP00000014960 H-----------------ILDLSNRFYTLIPH-DFGMKKPPLLNSLDYIQAKVQMLD----NLL-DIEVAYSLLRGG--A-Q--D------NESDPIDINYEKLKTKIEVVDKTTEEA-E T_nigroviridis_ENSTNIP00000019481 Q-----------------ILDLSNRFYTLIPH-DFGMKKPPLLSNLDYIQAKVQMLD----NLL-DIEVAYSLLRGG--A-Q--D------NENDPIDINYEKLKTKIEVIDKSAKEA-D O_latipes_ENSORLP00000017176 Q-----------------ILDLSNRFYTLIPH-DFGMKKPPLLNSLDYIQAKVEMLD----NLL-DIEVAYSLLRGG--A-Q--D------NEHDPIDINYEKLKTKIEVVDKSTQEA-E D_rerio_ENSDARP00000008364 L-----------------ILDLSNRFYTLIPH-DFGMKKPPLLSNVDYIQQKVQMLD----NLL-DIEVAYSLLRGG--V-E--N------NEKDPIDINYEKLKTKIEVVDKSSHEA-Q A_carolinensis_ENSACAP00000006218 Q-----------------ILDLSNRFYTLIPH-DFGMKKPPLLNSLDYIKSKVEMLD----NLL-DIEVAYSLLRSG--A-Q--D------GDKDPIDVNYEKLKTDIKVVDKDTDEA-K T_rubripes_ENSTRUP00000037062 Q-----------------ILDLSNRFYTLIPH-DFGMKKPPLLNNLNYIQAKVQMLD----NLL-DIEVAYSLLRGG--A-Q--D------NENDPIDINYEKLKTKIEVVDKSAKEA-D D_melanogaster_FBpp0112609 K-----------------LIDATNRFYTLIPH-NFGVQLPTLIETHQQIEDLRQMLD----SLA-EIEVAYSIIKSE--D-V--S------DACNPLDNHYAQIKTQLVALDKNSEEF-S H_sapiens_ENSP00000355759 Q-----------------ILDLSNRFYTLIPH-DFGMKKPPLLNNADSVQAKVEMLD----NLL-DIEVAYSLLRGG--S-D--D------SSKDPIDVNYEKLKTDIKVVDRDSEEA-E M_musculus_ENSMUSP00000027777 Q-----------------ILDLSNRFYTLIPH-DFGMKKPPLLNNADSVQAKVEMLD----NLL-DIEVAYSLLRGG--S-D--D------SSKDPIDVNYEKLKTDIKVVDRDSEEA-E P_pygmaeus_ENSPPYP00000000162 Q-----------------ILDLSNRFYTLIPH-DFGMRKPPLLNNADSVQAKVEMLD----NLL-DIEVAYSLLRGG--S-D--D------SSKDPIDVNYEKLKTDIKVVDRDSEEA-E C_familiaris_ENSCAFP00000023715 Q-----------------ILDLSNRFYTLIPH-DFGMKKPPLLNNADCVQAKVEMLD----NLL-DIEVAYSLLRGG--S-D--D------SSKDPIDVNYEKLKTDIKVVDRDSEEA-E R_norvegicus_ENSRNOP00000004232 Q-----------------ILDLSNRFYTLIPH-DFGMKKPPLLNNTDSVQAKVEMLD----NLL-DIEVAYSLLRGG--S-D--D------SSKDPIDVNYEKLKTDIKVVDRDSEEA-E B_taurus_ENSBTAP00000001113 H-----------------ILDLSNRFYTLIPH-DFGMKKPPLLNNANSVQAKVEMLD----NLL-DIEVAYSLLRGG--S-D--D------SSKDPIDVNYEKLKTDIKVVDKDSEEA-E E_caballus_ENSECAP00000017400 Q-----------------ILDLSNRFYTLIPH-DFGMKKPPLLNNTDSVQAKVEMLD----NLL-DIEVAYSLLRGG--S-D--D------SSKDPIDVNYEKLKTDIKVVDKDSEEA-E M_mulatta_ENSMMUP00000028737 Q-----------------ILDLSNRFYTLIPH-DFGMKKPPLLNSADSVQAKVEMLD----NLL-DIEVAYSLLRGG--S-D--D------SSKDPIDVNYEKLKTDIKVVGRDSEEA-E O_anatinus_ENSOANP00000002367 Q-----------------ILDLSNRFYTLIPH-DFGMKKPPLLNNMDCVQAKVEMLD----NLL-DIEVAYSLLRGG--S-E--D------GDKDPIDVNYEKLKTDIKVVDKDSEEA-R M_domestica_ENSMODP00000007535 Q-----------------ILDLSNRFYTLIPH-DFGMKKPPLLNNIDCVQAKVEMLD----NLL-DIEVAYSLLRGG--S-E--D------GSKDPIDVNYEKLKTDIKVVDQNSEEA-D P_troglodytes_ENSPTRP00000003457 Q-----------------ILDLSNRFYTLIPH-DFGMKKPPVLNNADSVQAKVEMLD----NLL-DIEVAYSLLRGG--S-D--D------SSKDPIDVNYEKLKTDIKVVDRDSEEA-E X_tropicalis_ENSXETP00000048934 R-----------------LLDLSNQFYTLIPH-DFGMKKPPLLNNLEYIQAKVQMLD----NLL-DIEVAYSLLRGG--A-D--D------GEKDPIDVKYEKIKTDIKVVDKESEES-R A_aegypti_AAEL011815-PA Q-----------------FIDASNRFYTLIPH-NFGVETPTVLDTVEQINEKQAMLD----SLT-EIEIAYSFLNTD--T-D--AK-------KNPLDAHYEQLKTDMETVKRDSEEF-K T_guttata_ENSTGUP00000004425 Q-----------------ILDLSNRFYTLIPH-DFGMKKPPLLNNLEYIQAKVQMLD----NLL-DIEVAYSLLRGG--N-E--D------GDKDPIDINYEKLKTDIKVVDKDSEEA-K G_gallus_ENSGALP00000038037 Q-----------------ILDLSNRFYTLIPH-DFGMKKPPLLSNLEYIQAKVQMLD----NLL-DIEVAYSLLRGG--N-E--D------GDKDPIDINYEKLRTDIKVVDKDSEEA-K A_gambiae_AGAP003230-PA E-----------------FIAASNRFYSYIPH-NFGVSSVKVLDTIEQVKEKQTMLE----SLM-EIEFAYSLLNDG--D-E--SA----QDGKNPLDAHYDQLKTSIEPMARDSEEF-A C_elegans_Y71F9AL.18.1 R-----------------ILDFSNKFYTIIPH-NFGMRVPEPIDSFHKIKEKNNMLN----ALL-DIKFAYDQISGG--D-VPAST----SLGIDPVDINYQKLKCIMEPLQQGCDDW-N A_carolinensis_ENSACAP00000011424 K-----------------LEELSSRFYTIIPH-NFGRCRPPAINTQEIIQAKKDMLL----VLA-DIELAQSLQAQKKEE-E--EEEEEMKEVPHPLDKDYGLLKCQLTLVDPSVADY-K T_rubripes_ENSTRUP00000005989 ------------------LEELSSKFFTTVPH-NFGRNRPPTINSQEIVEQKKEMLMLRAKVLA-DIELAQTLKSET--E-K--AQEEMIETVPHPLDQDYNSLRCRLSLLDTETETF-K X_tropicalis_ENSXETP00000000153 V-----------------LSDLSSRFYTIIPH-NFGRRTPPVIDTSEVLQAKKDMLL----VLA-DIELAQTLQADKVKK-E--EEEEKVQEVPHPLDVDYELLKCDLSLLDTSTEEY-K D_rerio_ENSDARP00000026625 ------------------FEELTNKFFTIIPH-NFGRNRPPVISDDSVLQSKKEMLL----VLA-DIEVAQSLKAES--E-K--AKEEMEDTVPHPVDQNYQSLKCSLNLVDKKSKEF-K M_domestica_ENSMODP00000014791 ------------------LEELSSRFYTIIPH-NFGRAKPPCICSQEILQTKKDMLL----VLA-DIELAKSLQAAG--E-D--EKKAKVEEVPHPLDRDYQLLKCQLQPLATDTHEY-K G_aculeatus_ENSGACP00000001175 N-----------------LEELSSKFFTTIPH-NFGRSRPPTIDDKEIVEKKKEMLM----VLA-DIELAQTLKSET--E-K--SQEEMTEKVPHPLDQDYRSLNCSLTLMDKDSDRFKK O_latipes_ENSORLP00000000924 ------------------LEELSSKFFTTIPH-NFGRNRPPTINTKEIIEHKKQMLM----VLA-DIELAQTLKSET--E-K--AQEEMIETVPHHLDQDYMSLKCKLSLLDKKSKTF-K P_pygmaeus_ENSPPYP00000015470 S-----------------LEELSSHFYTVIPH-NFGRSQPPPINSPELLQAKKDMLL----VLA-DIELAQALQAAS--E-Q--EK--MVEEVPHPLDRDYQLLKCQLQLLDSGAPEY-K H_sapiens_ENSP00000381740 S-----------------LEELSSHFYTVIPH-NFGHSQPPPINSPELLQAKKDMLL----VLA-DIELAQALQAVS--E-Q--EK--TVEEVPHPLDRDYQLLKCQLQLLDSGAPEY-K P_troglodytes_ENSPTRP00000025859 S-----------------LEELSSHFYTIIPH-NFGRSQPPPINSPELLQAKKDMLL----VLA-DIELAQALQAAS--E-Q--EK--MVEEVPHPLDRDYQLLKCQLQLLDSGAPEY-K B_taurus_ENSBTAP00000043156 S-----------------LEELSSHFYTIIPH-NFGRSRPPPINSPELLQAKKDMLL----VLA-DIELAQTLQAAP--E-E--TK--KVEEVPHPLDRDYQLLKCQLQLLGPETPEY-K E_caballus_ENSECAP00000016262 N-----------------LEELSSRFYTVIPH-NFGRSRPPPINSPELLQAKKDMLL----VLA-DIELAQTLQAAP--E----EK--KVEEVPHPLDRDYQLLKCQLQLLDPEAPDY-K G_gorilla_ENSGGOP00000012158 S-----------------LEELSSHFYTLIPH-NFSRSQPPPINSPELLQAKKDMLL----VLA-DIELAQALQAAS--E-Q--EK--MVEEVPHPLDRDYQLLKCQLQLLDSGAPEY-K C_familiaris_ENSCAFP00000014771 N-----------------LEELSSHFYTVIPH-NFSRNRPPPINSPELLQAKKDMLL----VLA-DIELAQTLQASP--E-E--EK---VEEVPHPLDRDYQLLKCQLQLLDPEEPEY-K R_norvegicus_ENSRNOP00000017224 S-----------------LEELSSCFYTVIPH-NFGRSRPPPINSPDILQAKKDMLL----VLA-DIELAQTLQAAP--G-E--EE--KVEEVPHPLDRDYQLLKCQLQLLDPGESEY-K O_cuniculus_ENSOCUP00000015305 X-----------------XXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXX----XXX-XXXXXXXXXXXX--X-X--X------XXXXXXXXXXXXXXXXXXVVDKDSEEA-E G_gallus_ENSGALP00000007181 R-----------------LEELSSRFYTIVPH-NFGRARPPPFDSPELLRAKKDMLL----VLA-DIEVAQSLQAQK--V-E--EE----EVVAHPLDRDYALLCCQLTLLEDTSQEY-E M_musculus_ENSMUSP00000108098 S-----------------LEELSSCFYTVIPH-NFGRSRPPPINSPDVLQAKKDMLL----VLA-DIELAQTLQAAP--GEE--EE--KVEEVPHPLDRDYQLLRCQLQLLDSGESEY-K M_mulatta_ENSMMUP00000029228 S-----------------LEELSSHFYTVIPH-NFGRSRPPPINSPELLQAKKDMLL----VLA-DIELAQALQAAP--E-Q--EK--MVEEVPHPLDRDYQLLKCQLQLLDSGAPEY-K T_guttata_ENSTGUP00000006583 G-----------------RQPWSCWQEAGLPW-S-------PAQCPALV-VRMSLLC-PCQVLA-DIEIARSLQAQK--E-K--EEEEEKKEVAHPLDQDYALLCCQLSLLDPASREY-Q G_gorilla_ENSGGOP00000006181 Q-----------------ILDLSNRFYTLIPH-DFGMKKPPLLNNADSVQAKVEMLD----NLL-DIEVAYSLLRGG--S-D--D------SSKDPIDVNYEKLKTDIKXXXXXXXXX-X T_nigroviridis_ENSTNIP00000017650 ------------------LEELSSKFFTAIPH-NFGRNRPPTIDSKEIVEQKKEMLM----VLA-DIELAQTLKSET--E-K--AQEEMIETVPHPLDQDYNSLRCVLSLLDTKTETF-K C_elegans_E02H1.4 RGRPRVADRVLAVKSDGPSLHDINKYYSLIPH-SFGFCVPPKIDSHAKIQAERELLD----ALKGSIEASLELKDLK--K-T--A------SSKDIYQRLYERLPCHLEPV---SEEIAG T_nigroviridis_ENSTNIP00000000045 -----------------------------------------------------------------------------------------------------------------------K C_elegans_ZK1005.1a QTGVVESNLLDAYIT---TSELSGDYYSLIPSGEYEFSNLTRLDNVEEIARHRARLN----RCQ-EIETATRLLCAA--EFR---------QDLDRVDYIRSAIQCEYRLETPDSDIS-Q H_sapiens_ENSP00000371419 Q-----------------LQKMMTEFYRLIPH-KGTMPKEV---NLGLLAKKADLCQ----LIR-DMVNVCETNLSK---------------PNPPSLAKYRALRCKIEHVEQNTEEF-L P_troglodytes_ENSPTRP00000009733 Q-----------------LQKMMTEFYRLIPH-KGTMPEEV---NLGLLAKKADLCQ----LIR-DMVNVCETNLSK---------------PNPPSLAKYRALRCKIEHVEQNTEEF-L M_musculus_ENSMUSP00000066130 Q-----------------LQKTMAEFYRLLPH-RHPASEEV---NLRLLAQKEDLCQ----LVR-DMVNVCETNLSK---------------PNPPSLAKYRALRCKIEHVDQNTEEF-S G_aculeatus_ENSGACP00000011271 E-----------------VASLLHEVHAVLLH-VAPSQTPP---TARLISQRLDLCQ----LIR-DVLNVSEMTMGS---------------SAPSSLGKYRAMRCSIDAVPPDSPEF-Q T_rubripes_ENSTRUP00000000233 E-----------------AASLLEEAQALMPF-REHRSE-----GLQSVSQKLDVCQ----LIR-DVLNVSEMTLRS---------------AAPSCLGKYRALRCSVEAVPADSSEF-L C_familiaris_ENSCAFP00000010963 Q-----------------LQKMMTEFYRLIPH-KGTTTEEV---DLRLLAKKEDLCQ----LIR-DMVNVCETNLFK---------------PSPPSLAKYRALRCKIEHVEQNTEEF-L B_taurus_ENSBTAP00000035522 Q-----------------LQTMLTEFYRLIPH-RAAVAEKV---SLSLLAKKEDLCQ----LIR-DMVNVCETNLAK---------------PNPPSLAKYRALRCKIEHVEPNTEEF-L X_tropicalis_ENSXETP00000043695 D-----------------IRKAMAEFYRLIPH-KKPLQAKI---DKELLSTKQDLCQ----LIR-DMVSVCETNSSK---------------PNPSSLAKYQALRCQIEHVEPNTEEF-H T_nigroviridis_ENSTNIP00000004824 -------------------MGVKEDAYRLIPV-------------STRCPRSLDVCQ----LIR-DLLNVSEMTLRS---------------SAPSCLGKYRALRCSLEAVPPNSSEF-L E_caballus_ENSECAP00000007671 Q-----------------LQKMMTEFYRLVPH-KGATAEQI---TLRLLAKKEDLCQ----LIR-DMVNVCETNLAK---------------PNPPSLAKYRALRCKIEHVEENTEEF-F A_carolinensis_ENSACAP00000001773 E-----------------LSAMMMDFYQIIPH-KDALNCNV---TLKLLSNKQDLCQ----LIR-DMLNVQEINLST---------------PNPSSLSKYQALRCRIDALDAKTEEF-H G_gallus_ENSGALP00000027638 A-----------------LQEMMMEFYQLIRH-KTEIDYEV---SKRLLSRKQDLCQ----LMR-DMLNIRETSMSC---------------PNPSSLAKYQALRCKIDAVDPMSDEF-L M_domestica_ENSMODP00000009821 E-----------------LKKMMSKFYQLIPH-R-RMEDEV---NQSLLSKKEDLCQ----LIR-DVVNVNEANLSR---------------PNPPSFAKYRALRCKIEHIDENTREF-Y O_cuniculus_ENSOCUP00000012495 Q-----------------LQKLMAEFYRLIPH-KGPATEEV---NLKLLAKEEDLCQ----LIR-DMVNVCETNLSK---------------PNPPSLAKYRALRCKIEYVEQNTEEF-F 2170 2180 2190 2200 2210 2220 2230 2240 2250 2260 2270 2280 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 -------VISQYL-QSTHAPTHKDYTMTLLDVFEVEKEGEKEA--FR--EDLP---------------------N---RMLLWHGSRLSNWVGILSHGLRVAPPEAPITG------YMFG R_norvegicus_ENSRNOP00000011840 -------VISQYL-QSTHAPTHKDYTMTLLEVFEVEKEGEKEA--FR--KDLP---------------------N---RMLLWHGSRLSNWVGILSHGLRVAPPEAPITG------YMFG C_familiaris_ENSCAFP00000008035 -------VISQYL-QSTHAPTHKDYTMTLLDVFEVEKEGEKEA--FR--EDLH---------------------N---RMLLWHGSRLSNWVGILSHGLRIAPPEAPVTG------YMFG B_taurus_ENSBTAP00000012338 -------VISQYL-QSTHAPTHSDYTMTLLDVFEVEKEGEKEA--FR--EDLH---------------------N---RMLLWHGSRLSNWVGILSHGLRIAPPEAPITG------YMFG H_sapiens_ENSP00000250416 -------VISQYL-QSTHAPTHSDYTMTLLDLFEVEKDGEKEA--FR--EDLH---------------------N---RMLLWHGSRMSNWVGILSHGLRIAPPEAPITG------YMFG P_troglodytes_ENSPTRP00000010339 -------VISQYL-QSTHAPTHSDYTMTLLDLFEVEKDGEKEA--FR--EDLH---------------------N---RMLLWHGSRMSNWVGILSHGLRIAPPEAPITG------YMFG P_pygmaeus_ENSPPYP00000006331 -------VISQYL-QSTHAPTHSDYTMTLLDLFEVEKEGEKEA--FR--EDLH---------------------N---RMLLWHGSRLSNWVGILSHGLRIAPPEAPITG------YMFG E_caballus_ENSECAP00000004152 -------VISQYL-QSTHAPTHSDYTMTLLDVFEVEKEGEKEA--FR--EDLH---------------------N---RMLLWHGSRLSNWVGILSHGLRIAPPEAPITG------YMFG M_mulatta_ENSMMUP00000021361 -------VISQYL-QSTHAPTHSDYTMTLLDLFEVEKEGEKEA--FR--EDLH---------------------N---RMLLWHGSRLSNWVGILSHGLRIAPPEAPITG------YMFG O_cuniculus_ENSOCUP00000001988 -------VISQYL-QSTHAPTHNDYTMTLLDVFEVEKEGEKEA--FR--EDLH---------------------N---RMLLWHGSRLSNWVGILSHGLRIAPPEAPITG------YMFG M_domestica_ENSMODP00000008892 -------VISQYL-HSTHAPTHNDYTMTLLDVFEVEKEGENEA--FR--KDLP---------------------N---RMLLWHGSRLGNWVGILSHGLRIAPPEAPVTG------YMFG A_carolinensis_ENSACAP00000008175 -------VLERYL-SSTHAPTHQDYTMTLLEVFVLKKENADSDSVFC--SDLP---------------------N---RMLLWHGSRLGNWAGILSQGLRVAPPEAPVTG------YMFG X_tropicalis_ENSXETP00000003642 -------LIDGYL-QSTHAPTHNDYTMTLLQVFELQRMGEECS--FR--ADLP---------------------N---RMLLWHGSRLTNWVGILSQGLRVAPPEAPVTG------YMFG O_latipes_ENSORLP00000003778 -------VIEKYL-QSTHAPTHRDYGMTVLDIFSVDRDGESES--FL--SDLH---------------------N---RTLLWHGSRLSNWVGILSKGLRVAPPEAPVTG------YMFG G_aculeatus_ENSGACP00000023516 -------VIEKYL-HSTHASTHCDYTMTLLDIFSVDRQGERNN--FL--SQMH---------------------N---RTLLWHGSRLSNWVGILSQGLRVAPPEAPVTG------YMFG T_nigroviridis_ENSTNIP00000006847 -------VIEKYL-QSTHAPTHSDYTMSVLDIFGVDREGESDS--FL--SDLP---------------------NSLPRTLLWHGSRLSNWVGILSQGLRVAPPEAPVTG------YMFG T_rubripes_ENSTRUP00000027488 -------VIEKYL-QSTHAPTHSDYTMTVIDIFTIDREGESNN--FL--SHFH---------------------NSLTRTLLWHGSRLSNWVSILSQGLRVAPPEAPVTG------YMFG C_intestinalis_ENSCINP00000018492 -------LVQEYV-KNTHAATHMNYELSIEDVFTLAKENDKN---FT--KDIG---------------------N---RVLLWHGSRLTNWCGILKNGLRIAPPEAPVTG------HMFG C_intestinalis_ENSCINP00000011691 -------IVKKYV-SNTHGSTHTSYTLSVEDVFTVNREVDSAR--FK--SEIG---------------------N---RTLLWHGSRLTNWCGILKQGLRIAPPEAPVTG------YMFG G_aculeatus_ENSGACP00000014960 -------IILQYV-KNTHAATHNTYTLEVQEIFKIVREGERQR--FRPFEELH---------------------N---RQLLWHGSRATNYAGIMSQGLRIAPPEAPVTG------YMFG T_nigroviridis_ENSTNIP00000019481 -------IILQYV-KNTHAATHNTYTLEVQEIFKICREGEHQR--YRPFEELH---------------------N---RQLLWHGSRTTNYAGIMSQGLRIAPPEAPVTG------YMFG O_latipes_ENSORLP00000017176 -------VITQYV-KNTHAATHNTYTLEVQEIFKIGREGERQR--FRPFEELH---------------------N---RQLLWHGSRATNYAGIMSQGLRIAPPEAPVTG------YMFG D_rerio_ENSDARP00000008364 -------LILQYV-KNTHAATHNTYTLDVEEIFKIEREGEYQR--YRPFKELP---------------------N---RQLLWHGSRTTNYAGILSQGLRIAPPEAPVTG------YMFG A_carolinensis_ENSACAP00000006218 -------IIKQYV-KNTHASTHNAYDLEVVEIFKIEREGEYQR--YKPFRELH---------------------N---RQLLWHGSRATNFAGILSQGLRIAPPEAPVTG------YMFG T_rubripes_ENSTRUP00000037062 -------IILQYV-KNTHAATHNTYTLEVQEIFKIRREGEHQR--YRPFEELH---------------------N---RQLLWHGSRATNYAGIMSQGLRIAPPEAPVTG------YMFG D_melanogaster_FBpp0112609 -------ILSQYV-KNTHASTHKSYDLKIVDVFKVSRQGEARR--FKPFKKLH---------------------N---RKLLWHGSRLTNFVGILSHGLRIAPPEAPPTG------YMFG H_sapiens_ENSP00000355759 -------IIRKYV-KNTHATTHNAYDLEVIDIFKIEREGECQR--YKPFKQLH---------------------N---RRLLWHGSRTTNFAGILSQGLRIAPPEAPVTG------YMFG M_musculus_ENSMUSP00000027777 -------VIRKYV-KNTHATTHNAYDLEVIDIFKIEREGESQR--YKPFRQLH---------------------N---RRLLWHGSRTTNFAGILSQGLRIAPPEAPVTG------YMFG P_pygmaeus_ENSPPYP00000000162 -------IIRKYV-KNTHATTHNAYDLEVIDIFKIEREGECQR--YKPFKQLH---------------------N---RRLLWHGSRTTNFAGILSQGLRIAPPEAPVTG------YMFG C_familiaris_ENSCAFP00000023715 -------TIRKYV-KNTHATTHNAYDLEVVDIFKIEREGESQR--YKPFKQLH---------------------N---RRLLWHGSRTTNFAGILSQGLRIAPPEAPVTG------YMFG R_norvegicus_ENSRNOP00000004232 -------VIRKYV-KNTHATTHNAYDLEVIDIFKIEREGESQR--YKPFRQLH---------------------N---RRLLWHGSRTTNFAGILSQGLRIAPPEAPVTG------YMFG B_taurus_ENSBTAP00000001113 -------IIRKYV-KNTHATTHNAYDLEVVDIFKIEREGESQR--YKPFKQLH---------------------N---RRLLWHGSRTTNFAGILSQGLRIAPPEAPVTG------YMFG E_caballus_ENSECAP00000017400 -------TIRKYV-KNTHATTHNAYDLEVVDIFKIEREGESQR--YKPFKQLH---------------------N---RRLLWHGSRTTNFAGILSQGLRIAPPEAPVTG------YMFG M_mulatta_ENSMMUP00000028737 -------IIRKYV-KNTHATTHNAYDLEVIDIFKIEREGECQR--YKPFKQLH---------------------N---RRLLWHGSRTTNFAGILSQGLRIAPPEAPVTG------YMFG O_anatinus_ENSOANP00000002367 -------IIREYV-KNTHATTHNAYDLQVVDIFKIEREGESQR--YKPFKQLH---------------------N---RQLLWHGSRATNFAGILSQGLRIAPPEAPVTG------YMFG M_domestica_ENSMODP00000007535 -------IIRQYV-KNTHATTHNAYDLEIIDIFKIERDGESQR--YKPFKQLH---------------------N---RRLLWHGSRATNYAGILSQGLRIAPPEAPVTG------YMFG P_troglodytes_ENSPTRP00000003457 -------IIRKYV-KNTHATTHNAYDLEVIDIFKIEREGECQR--YKP-KQFH---------------------N---RRLMWHGSRTTNFAGIMSKGLRIAPREAPVTG------YMFG X_tropicalis_ENSXETP00000048934 -------IIRDYV-KNTHAETHNAYDLEVLEIFKIEREGEYQR--YKPFKQLH---------------------N---RQLLWHGSRTTNFAGILSQGLRIAPPEAPVTG------YMFG A_aegypti_AAEL011815-PA -------ILEQYV-KNTHAETHTAYELEIGEIFKIKRKGEDRR--YKPFRKLH---------------------N---RKLLWHGSRLTNYVGILSHGLKIAPPEAPVTG------YMFG T_guttata_ENSTGUP00000004425 -------IIKQYV-KNTHAATHNAYDLKVVDIFRIEREGESQR--YKPFRQLH---------------------N---RQLLWHGSRTTNFAGILSQGLRIAPPEAPVTG------YMFG G_gallus_ENSGALP00000038037 -------IIKQYV-KNTHAATHNAYDLKVVEIFRIEREGESQR--YKPFKQLH---------------------N---RQLLWHGSRTTNFAGILSQGLRIAPPEAPVTG------YMFG A_gambiae_AGAP003230-PA -------LLEQYV-RNTHAETHRTYELEVAEIFRIKRKGEDRR--YQPFKKLH---------------------N---RKLLWHGSRLTNFAGILTNGLKIAPPEAPVTG------YMFG C_elegans_Y71F9AL.18.1 -------MIHQYL-KNTHGATH-DLKVELIDILKLNRDNESSK--FK--RHIG---------------------N---RRLLWHGSGKMNFAGILGQGLRIAPPEAPVSG------YMFG A_carolinensis_ENSACAP00000011424 -------LIVNYI-EKTGCSYR---KLNVMNIWKVNRESENSR--FKIHDHLQ---------------------N---RRLLWHGTNIAVVAAILKSGLRIMPH----SG------GRVG T_rubripes_ENSTRUP00000005989 -------IIQKYL-EMTSNGYR---NPKILNVWEADRETEGER--FGENDSLE---------------------N---RRLLWHGTNIAVVAAILKSGLRIMPH----SG------GRVG X_tropicalis_ENSXETP00000000153 -------VIKTYV-ENTGPTYR---TLKIQNVWCVNRETEEER--FSAHKDIE---------------------N---RRLLWHGTNIAVVVAILKSGLRIMPH----SG------GRVG D_rerio_ENSDARP00000026625 -------IIEKYL-KATGQE-----GLTLVDVWEVDRETEAER--FRENDALE---------------------N---RKLLWHGTNVAVVAAILKSGLRIMPH----SG------GRVG M_domestica_ENSMODP00000014791 -------LIQTYV-EKTGWS-----HLRILHVWKVNREGEGDR--FQAHAQIG---------------------N---RRLLWHGTNVAVVAAILKSGLRIMPH----SG------GRVG G_aculeatus_ENSGACP00000001175 -------IIEKYM-KETSDNYR---KPKIVNVWEVDRETEGER--FSENDGLE---------------------N---RRLLWHGTNIAVVAAILKSGLRIMPH----SG------GRVG O_latipes_ENSORLP00000000924 KGKKTXXXIETYL-KATSDKFY---NPTIVNVWEVDREMEGQR--FAENDKLE---------------------N---RRLLWHGTNIAVVAAILKSGLRIMPQ----SG------GRVG P_pygmaeus_ENSPPYP00000015470 -------VIQTYL-EQTGSNHR---CPTLQHIWKVNREGEEDR--FQAHSKLG---------------------N---RKLLWHGTNMAVVAAILTSGLRIMPH----SG------GRVG H_sapiens_ENSP00000381740 -------VIQTYL-EQTGSNHR---CPTLQHIWKVNQEGEEDR--FQAHSKLG---------------------N---RKLLWHGTNMAVVAAILTSGLRIMPH----SG------GRVG P_troglodytes_ENSPTRP00000025859 -------VIQTYL-EQTGSNHR---CPTLQHMWKVNREGEEDR--FQAYSKLG---------------------N---RKLLWHGTNMAVVAAILTTGLRIMPH----SG------GRVG B_taurus_ENSBTAP00000043156 -------VVHAYL-KQTSNSDR---PPALQ----VDREGEGDR--FQVHAKLG---------------------N---RKLLWHGTNVAVVAAILTSGLRIMPH----SG------GRVG E_caballus_ENSECAP00000016262 -------VIHTYL-KHTGNNYR---CPALQHVWKVNREGEGDR--FQAHSKLG---------------------N---RRLLWHGTNVAVVAAILTSGLRIMPH----SG------GRVG G_gorilla_ENSGGOP00000012158 -------VIQTYL-EQTGSNHR---CPTLQHIWKVNREGEEDR--FQAHSKLG---------------------N---RKLLWHGTNMAVVAAILTSGLRIMPH----FG------GRVG C_familiaris_ENSCAFP00000014771 -------VIHTYL-EKTGGTYR---CPALQHIWKVNREGEGDR--FQAHSKLS---------------------N---RKLLWHGTNVAVVAAILASGLRIMPH----SG------GRVG R_norvegicus_ENSRNOP00000017224 -------AIQTYL-EQTGNGYR---RPDLQHVWKVNREGEGDR--FQAHSKLG---------------------N---RRLLWHGTNVAVVAAILTSGLRIMPH----SG------GRVG O_cuniculus_ENSOCUP00000015305 -------VIRKYV-KNTHATTHNAYDLEVVDIFKIERDGESQR--YKPFKQLH---------------------N---RRLLWHGSRTTNFAGILSQGLRIAPPEAPVTG------YMFG G_gallus_ENSGALP00000007181 -------MILNYV-AQTGGQV------YVLNVWRVAREGEDKL--FQAHDHLE---------------------H---RRLLWHGTNVAVVAAILKNGLRIMPH----SG------GRVG M_musculus_ENSMUSP00000108098 -------AIQTYL-KQTGNSYR---CPDLRHVWKVNREGEGDR--FQAHSKLG---------------------N---RRLLWHGTNVAVVAAILTSGLRIMPH----SG------GRVG M_mulatta_ENSMMUP00000029228 -------VSLGHTSEQQGKAPE---CLGGRTPISHFLSTQEDR--FQAHSKLG---------------------N---RKLLWHGTNTAVVAAILTSGLRIMPH----SG------GRVG T_guttata_ENSTGUP00000006583 -------LIQTYV-MQTGHKL------HILNIWQVARDGEDEC--FKAHDLLE---------------------H---RRLLWHGTNVAVVAAILKSGLRIMPH----SG------GRVG G_gorilla_ENSGGOP00000006181 -------XXXXXX-XXXXXXXXXXXXXXXXXIFKIEREGECQR--YKPFKQLH---------------------N---RRLLWHGSRTTNFAGILSQGLRIAPPEAPVTG------YMFG T_nigroviridis_ENSTNIP00000017650 -------V---------------------------------------------------------------------------------------------------------------- C_elegans_E02H1.4 -------KIGDCL--AMRGPTH-CYKLSLIDAFELKDPNEIPT--EAPVEVQEVPKKRGRKSTKTAAPTVPPPTT---KRLLWHGTRVTNVFSILMNGLQF--PVGDRCG------LMFG T_nigroviridis_ENSTNIP00000000045 -------IIEKYL-KMTSGGYR---SPKILNVWEVDRETEGER--FGENDGLE---------------------N---RRLLWHGTNIAVVAAILKSGLRIMPH----SG------GRVG C_elegans_ZK1005.1a -------RLLQWI-HNSGGK-----QAKVKMILEISPMLSTEK--FEPFVNDD---------------------N---QKFLWHGTKATNLMSILKNGFLIDPPSACKNG------NLFG H_sapiens_ENSP00000371419 -------RVRKEVLQNHHSK----SPVDVLQIFRVGRVNETTE--FL--SKLG---------------------N---VRPLLHGSPVQNIVGILCRGLLLPK-VVEDRGVQRTDVGNLG P_troglodytes_ENSPTRP00000009733 -------RVRKEVLQNHHSK----SPVDVLQIFRVGRVNETTE--FL--SKLG---------------------N---VRPLLHGSPVRNIVGILCRGLLLPK-VVEDRGVQRTDVGNLG M_musculus_ENSMUSP00000066130 -------RVRKEVLQNNRSE----QPVDILQIFRVGRVNEATE--FL--SKLG---------------------N---VRLLFHGSPVRNILGILSRGLLLPK-VAEDRGVQRTDVGNLG G_aculeatus_ENSGACP00000011271 -------AVAALVRDSLHTCSGACSRVHVQRVLRVSRGAELQA--FK--SELG---------------------N---IKPLLHSSSPSNFVGVLSRGLLLPRVGVEHHGIERTDVGSLG T_rubripes_ENSTRUP00000000233 -------DVAAQLRH---------SQVQIQQVLRVCRGVELQT--FK--ADVG---------------------N---VEPLLHSSKPSNFVGLLSRGLLMPRVGVEHHGIKRTDVGNLG C_familiaris_ENSCAFP00000010963 -------RVRKEVLQNNHSQ----VPVDILQIFRVGKVNEATE--FL--SQLG---------------------N---VKPLLHGSPVQSFIGILSRGLLLPK-VVEDRGTKRTDIGNLG B_taurus_ENSBTAP00000035522 -------RVREEVLQNNHSK----GPVDILQIFRVGRVSETTE--FQ--GHLG---------------------N---VRHLLHGSPVQSFMGILSRGLLLPK-VVEDRGMKRTDIGNLG X_tropicalis_ENSXETP00000043695 -------QVSQQIVENKHCE----ESINILKIFRVGKLSEATG--FQ--KNLG---------------------N---VKSLLHASSPRHFVGILSRGLLLPKNVEDDLGLKRTDIGNLG T_nigroviridis_ENSTNIP00000004824 -------DVAAQLQH---------SRVQIQQVLRVCRGVELQT--FE--ADVG---------------------G---IKPLLHSSRPSNFVGLLSRGLLMPRVGVEHHGIERTDAGNLG E_caballus_ENSECAP00000007671 -------RVRKELLQDNCGR----SPVNILQIFRVGKVNETTE--FL--SRLG---------------------T---VKRLLHGSPVRSFVGILSRGLLLPK-VVEARGVKRTDIGNLG A_carolinensis_ENSACAP00000001773 -------RIKQRVDQDT-SK----CPVEILEIYKVGRITEAAG--FE--SRLG---------------------N---VQSLIHASSPGNFVGILSRGLLLPKMAVEEHGLERTDFGNLG G_gallus_ENSGALP00000027638 -------SVERQVLKNNYNG----CSVRILQVYRIGRVSETAE--FL--GSLG---------------------N---VRSLFHASSVRNFMGILSRGLLMPKVVVEDHGVERTDTGNLG M_domestica_ENSMODP00000009821 -------NVKEEVLQKNYGK----NSVDILNIYRIGRINETLE--FQ--SKVG---------------------N---VQSLLHGTPGRNIVGILSRGLLLPKRLVEDYGIERTDFGNLG O_cuniculus_ENSOCUP00000012495 -------KIKKEILQSSRXX----XXXXXXXXXXXXXXXXXXX--XX--XXXX---------------------X---XXXXXXXXXXXXLVGILSRGLLLPK-VVEGRGVHRTDAGNLG 2290 2300 2310 2320 2330 2340 2350 2360 2370 2380 2390 2400 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 KGIYFADMS--SKSANYCFAS------RLKNTGLLLLSEVALGQCNELLE-----ANPKAQG--LLRGKHSTKGMGKMAPSPAHF-ITL-NG--STVPLGP-----A-SDTGILNPEGYT R_norvegicus_ENSRNOP00000011840 KGIYFADMS--SKSANYCFAS------RLKNTGLLLLSEVALGQCNELLE-----ANPKAEG--LLQGKHSTKGMGKMAPSPAHF-ITL-NG--STVPLGP-----A-SDTGILNPEGYT C_familiaris_ENSCAFP00000008035 KGIYFADMS--SKSANYCFAS------RVKDIGLLLLSEVALGQCNELLE-----ANPEAER--LLQGKHSTKGLGKTAPSPASF-ITL-NG--STVPLGP-----A-SDTGILNPDGYT B_taurus_ENSBTAP00000012338 KGIYFADMS--SKSANYCFAT------RLKDTGLLLLSEVALGQCNELLG-----ANPEAEG--LLQGKHSTKGLGKMAPSPACA-ITL-NG--STVPLGP-----A-SDTGILNPEGYT H_sapiens_ENSP00000250416 KGIYFADMS--SKSANYCFAS------RLKNTGLLLLSEVALGQCNELLE-----ANPKAEG--LLQGKHSTKGLGKMAPSSAHF-VTL-NG--STVPLGP-----A-SDTGILNPDGYT P_troglodytes_ENSPTRP00000010339 KGIYFADMS--SKSANYCFAS------RLKNTGLLLLSEVALGQCNELLE-----ANPKAEG--LLQGKHSTKGLGKMAPSSAHF-VTL-NG--STVPLGP-----A-SDTGILNPDGYT P_pygmaeus_ENSPPYP00000006331 KGIYFADMS--SKSANYCFAS------RLKNTGLLLLSEVALGQCNELLE-----ANPKAEG--LLQGKHSTKGLGKMAPSSAHF-VTL-NG--STVPLGP-----A-SDTGILNPDGYT E_caballus_ENSECAP00000004152 KGIYFADMS--SKSANYCFAS------HLKDTGLLLLSEVALGQCNELLE-----ANPEAEG--LLQGKHSTKGLGKMAPSPACF-TTL-NG--STVPLGP-----A-SETGILNPEGYT M_mulatta_ENSMMUP00000021361 KGIYFADMS--SKSANYCFAS------HLKNIGLLLLSEVALGQCNELLE-----ANPKAEG--LLQGKHSTKGLGKMAPSSAHF-VTL-NG--STVPLGP-----A-SDTGILNPDGYT O_cuniculus_ENSOCUP00000001988 KGIYFADMS--SKSANYCFAS------RLKNIGLLLLSEVALGHCNELLE-----ANPKAEG--LLQGKHSTKGLGKMAPNPTSS-ITL-NG--STVPLGP-----A-SDTGILNPEGYT M_domestica_ENSMODP00000008892 KGIYFADMS--SKSANYCFAS------RLKDTGLLLLSEVALGECNELLE-----ANPEAAG--LLQGKHSTKGMGKMAPNPSHY-VSL-NG--TTVPLGP-----V-SGTGILNPQGYT A_carolinensis_ENSACAP00000008175 KGIYFADMS--SKSANYCFAT------REKDIGLLLLSEVALGECNELLE-----ANHEAEK--LLAGKHSTKGLGKLAPSPANS-VTL-HG--AVVPLGP-----A-IDTGVTNPHGYT X_tropicalis_ENSXETP00000003642 KGIYFADVS--SKSANYCFSS------RDKNVGVLLLSEVALGESNELLA-----ADYDAQK--KLKSKHSTKGLGRSIPDPKNS-ITH-DG--AVVPLGP-----L-IDTGMTNDSDYT O_latipes_ENSORLP00000003778 KGIYFADMS--SKSANYCFAN------QSNHVGLLLLCEVALGDCNELLD-----ADYEANN--LPAGKHSTKGLGQTAPDPKNS-VTL-DG--VTVPMGP-----G-VKTGAANSSGYS G_aculeatus_ENSGACP00000023516 KGIYFADMS--SKSANYCFAS------QNNHVGLLLLCEVALGDSNELLD-----ADYEANN--LPAGKHSTKGLGRTGPHPQTS-VNL-DG--VTVPMGP-----A-VETGVGKNRCYS T_nigroviridis_ENSTNIP00000006847 KGIYFADMS--SKSANYCFAN------QSNHVGLLLLCEVALGDSNELLD-----ADYEANN--LPNGKHSTKGLGRTGPDPKNA-LTL-EG--VTVPMGP-----G-VNTGVGKHKSYT T_rubripes_ENSTRUP00000027488 KGIYFADMS--SKSANYCFAN------QSNHIGLLLLCEV-------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000018492 KGIYFADMV--SKSANYCYAT------HRQPKAFLLLCEVALGESNNLLQ-----ADYNANK--LPKGKHSVKGLGKTQPDPSKSKYTD-DG--VLVPCGL-----PVSEEGSKNS---A C_intestinalis_ENSCINP00000011691 KGVYFADMV--SKSANYCWTS------QRQPIGFLLLCEVALGDCNELTS-----GDYHADK--LPKGKHSTKGIGGTEPNPKQA-VTLADG--TTVPLGK-----P-KTCTTKPG---Y G_aculeatus_ENSGACP00000014960 KGVYFADMV--SKSANYCHTS------RSEPVGLLLLAEVALGNMHELKK-----ASH-ITK--LPKGKHSVKGLGRSAPDPSAS-VTL-DG--VQVPVGK-----G-TNTNIDDT---S T_nigroviridis_ENSTNIP00000019481 KGVYFADMV--SKSANYCHTS------QSEPVGLLLLAEVALGNMHELKK-----ASH-ITK--LPKGKHSVKGLGRTAPDPNAT-VTL-DG--VQVPLGR-----G-VNTNIDDT---S O_latipes_ENSORLP00000017176 KGVYFADMV--SKSANYCHTS------QSDPVGLILLAEVALGNMHELKK-----ASH-ITK--LPKGKHSVKGLGRTAPDPSAT-VTL-DG--VQVPLGK-----G-VQTNIDDT---S D_rerio_ENSDARP00000008364 KGVYFADMV--SKSANYCHTS------QADPVGLILLGEVALGNMHELKK-----ASH-ITK--LPKGKHSVKGLGRSAPDPRAT-VSL-NG--VDIPLGK-----G-MNTNIDDT---S A_carolinensis_ENSACAP00000006218 KGIYFADMV--SKSANYCHTS------QTDSVGLILLGEVALGNMYELKN-----ASH-ITK--LPKGKHSVKGLGKTAPDPSAT-VSL-NG--VDVPLGS-----G-IPSGVSNT---C T_rubripes_ENSTRUP00000037062 KGVYFADMV--SKSANYCHTS------QSEPVGFLLLAEVALGNMHELKK-----ASH-ITK--LPKGKHSVKGLGRTAPDPSAT-VTL-DG--VQVPLGN-----G-VNTNIDDT---S D_melanogaster_FBpp0112609 KGIYFADMV--SKSANYCCTS------QQNSTGLMLLSEVALGDMMECTS-----AKY-INK--LSNNKHSCFGRGRTMPDPTKSYIRS-DG--VEIPYGE-----T-ITDEHLKS---S H_sapiens_ENSP00000355759 KGIYFADMV--SKSANYCHTS------QGDPIGLILLGEVALGNMYELKH-----ASH-ISK--LPKGKHSVKGLGKTTPDPSAN-ISL-DG--VDVPLGT-----G-ISSGVNDT---S M_musculus_ENSMUSP00000027777 KGIYFADMV--SKSANYCHTS------QGDPIGLILLGEVALGNMYELKH-----ASH-ISK--LPKGKHSVKGLGKTTPDPSAS-ITL-EG--VEVPLGT-----G-IPSGVNDT---C P_pygmaeus_ENSPPYP00000000162 KGIYFADMV--SKSANYCHTS------QGDPIGLILLGEVALGNMYELKH-----ASH-ISK--LPKGKHSVKGLGKTTPDPSAS-ISL-DG--VEVPLGT-----G-ISSGVNDT---C C_familiaris_ENSCAFP00000023715 KGIYFADMV--SKSANYCHTS------QGDPIGLILLGEVALGNMYELKH-----ASH-ISK--LPKGKHSVKGLGKTTPDPSAS-ITL-DG--VEVPLGT-----G-ISSGVNDT---C R_norvegicus_ENSRNOP00000004232 KGIYFADMV--SKSANYCHTS------QGDPIGLILLGEVALGNMYELKH-----ASH-ISK--LPKGKHSVKGLGKTAPDPSAS-ITL-DG--VEVPLGT-----G-IPSGVNDT---C B_taurus_ENSBTAP00000001113 KGIYFADMV--SKSANYCHTS------QGDPIGLILLGEVALGNMYELKH-----ASH-ISK--LPKGKHSVKGLGKTTPDPSAS-ITV-DG--VEVPLGT-----G-ISSGVNDT---C E_caballus_ENSECAP00000017400 KGIYFADMV--SKSANYCHTS------QGDPIGLILLGEVALGNMYELKH-----ASH-ISK--LPKGKHSVKGLGKTTPDPSAS-VTM-DG--VEVPLGT-----G-ISSGVSDT---C M_mulatta_ENSMMUP00000028737 KGIYFADMV--SKSANYCHTS------QGDPIGLIVLGEVALGNMYELKH-----ASH-ISK--LPKGKHSVKGLGKTTPDPSAS-ISL-DG--VEVPLGT-----G-ISSGVNDT---C O_anatinus_ENSOANP00000002367 KGIYFADMV--SKSANYCHTS------QGDPIGLILLGEVALGNMYELKN-----ASH-ISK--LPKGKHSVKGLGKTAPDPSAS-ITL-DG--VEVPLGT-----G-ISSGVSDT---C M_domestica_ENSMODP00000007535 KGIYFADMV--SKSANYCHTS------QGDPIGLILLGEVALGNMYELKH-----ASH-ISK--LPKGKHSVKGLGKTTPDPTAS-ITL-DG--VEIPLGT-----G-VSSGVSDT---C P_troglodytes_ENSPTRP00000003457 KGIYFADMV--SKSANYCHTS------QGDPIGLILLGEVALGNMYELKH-----ASH-ISK--LPKGKHSVKGLGKTTPDPSAN-ISL-DG--VDIPLGT-----G-ISSGVNDT---S X_tropicalis_ENSXETP00000048934 KGIYFADMV--SKSANYCNAM------PGNPIGLILLGEVALGNMHELRA-----ASH-ITK--LPKGKHSVKGLGRTAPDPSAT-VKL-DG--VDVPLGK-----G-SATNITDA---S A_aegypti_AAEL011815-PA KGIYFADMV--SKSANYCCTS------PSNSTGLMLLCEVALGDMVEYKQ-----AHY-VTK--LPADKHSTKGIGRTQPNPKEAHVRP-DG--VEIPLGK-----GVVQDPKLMT---S T_guttata_ENSTGUP00000004425 KGIYFADMV--SKSANYCHTS------QADPIGLVLLGEVALGNMYELKN-----ASH-ITK--LPKGKHSVKGLGKTAPDPTAT-TTL-GG--VEVPLGN-----G-ISTGINDT---C G_gallus_ENSGALP00000038037 KGIYFADMV--SKSANYCHTS------QADPIGLILLGEVALGNMYELKN-----ASH-ITK--LPKGKHSVKGLGKTAPDPTAT-TTL-DG--VEVPLGN-----G-ISTGINDT---C A_gambiae_AGAP003230-PA KGIYFADMV--SKSANYCCTN------VADSTGLLLLCEVALGDMQEYTQ-----AHY-VTK--LSTGKHSVKGIGRTQPDPTGSHVRP-DG--VEIPMGK-----G-VSNEKLKS---S C_elegans_Y71F9AL.18.1 KGVYFADMF--SKSFFYCRAN------AKEE-AYLLLCDVALGNVQQLMA-----SKN-VSRQTLPAGFQSVQGLGRQCPREIGS-YNHPDG--YTIPLGL-----TYMQLQGKQDVDYH A_carolinensis_ENSACAP00000011424 KGLYFASEN--SKSAGYA--L-DCEHGGSHQVGIMFLNEVALGKEHRITC-----DDSSLRK--PPDGYDSVLACGRTEPDPAHDKELILDGKKVLISQGK-----PIPIKQYESS---S T_rubripes_ENSTRUP00000005989 RGIYFASEN--SKSAGY---V-R----TSKNTGVMFLCEVALGKEKTITV-----DNSSLKK--APAGFDSVVARGRVEPDPKEDTFITLEGKKVSVPQGP-----PVDQPQYSGS---H X_tropicalis_ENSXETP00000000153 KGIYFASEN--SKSAGYV----GC---TSKNLGIMFLNEVALGREHHIKM-----DDCSLQS--PPKGYDSVVARGLTEPEPAKDRKLDLDGRKITVPQGR-----PVKMEKYSDS---S D_rerio_ENSDARP00000026625 RGIYFASEN--SKSAGYVR--------PSNKIGIMFLNEVALGKEYTITR-----DDPSLRK--APAGYDSVIARGNQEPDPSKDVFIELDGKKVVVPQGK-----AIKQQQYEGS---H M_domestica_ENSMODP00000014791 KGIYFASEN--SKSASYV----GC---TSQKIGLMFLSEVVLGQVHHITG-----DDPSLRE--PPSGYHSVIARGRTEPDPSQDVELELEGHKVVVPQGP-----PVILPSFQES---S G_aculeatus_ENSGACP00000001175 SGIYFASEN--RKSACY---V-R----PSKNTGVMFLSEVALGKEFTITN-----DDGALKE--APAGYDSVVARGSVEPDPSKDTIITLEGKQVAVPQGK-----PVKQPQFSNS---R O_latipes_ENSORLP00000000924 RGIYFASEN--SKSICYEILV-R----TSNKTGVMFLSEVALGREYTITK-----DEPSLKE--APSGFDSVVARGRVEPDPSKDTFITLEGKEVAVPQGK-----AQHQPRFSNS---S P_pygmaeus_ENSPPYP00000015470 KGIYFASEN--SKSAGYVTGM-KC---GAHHVGYMFLGEVALGREHHINT-----DNPSLKS--PPPGFDSVIARGHTEPDPTQDTELELDGQQVVVPQGQ-----PVPCPEFSRS---T H_sapiens_ENSP00000381740 KGIYFASEN--SKSAGYVIGM-KC---GAHHVGYMFLGEVALGREHHINT-----DNPSLKS--PPPGFDSVIARGHTEPDPTQDTELELDGQQVVVPQGQ-----PVPCPEFSSS---T P_troglodytes_ENSPTRP00000025859 KGIYFASEN--SKSAGYVIGM-KC---GAHHVGYMFLGEVALGREHHINT-----DNPSLKS--PPPGFDSVIARGHTEPDPTQDTELELDGQQVVVPQGQ-----PVPCPEISSS---T B_taurus_ENSBTAP00000043156 NGICFSSEN--HKSAGCVIGI-SC---GAHHIGYMFLGEVALGREYHITV-----DEPRLKQ--PPSGFDSVIARGHTEPDPTRDTELELDGQRVVVPQGQ-----PVLCPDFRSC---N E_caballus_ENSECAP00000016262 KGIYFASEN--SKSAGYVTGM-RC---GAHHIGYMFLSEVALGREHHITI-----DEPSLKQ--PPPGFDSVIARGHTEPDPTQDTELELDGQKVVVPQGP-----PMPCPEFSSS---S G_gorilla_ENSGGOP00000012158 KGIYFASEN--SKSAGYVIGM-KC---GAHHVGYMFLGEVALGREHHINT-----DNPSLKS--PPPGFDSVIARGHTEPDPTQDTELELDGQQVVVPQGQ-----PVPCPDFSSS---T C_familiaris_ENSCAFP00000014771 KGIYFASEN--SKSAGYVTGI-SC---GAHQIGYMFLGEVALGREHHITI-----DDPSLKQ--PPPGFDSVIARGSTEPDPSQDTELELDGQRVVVPQGQ-----PVPCAEFSSS---R R_norvegicus_ENSRNOP00000017224 KGIYFASEN--SKSASYVTAM-RC---GSHQVGYMFLGEVALGKVHHITM-----DDPSLKS--PPPGFDSVIARGQTEPDPAQDIELQLDGQPVVVPQGR-----PVACPSFKSS---S O_cuniculus_ENSOCUP00000015305 KGIYFADMV--SKSANYCHTS------QGDPIGLILLGEVALGNXXXXXX-----XXX-XXX--XXXXXXXXXXLGKTTPDPSAS-ITL-DG--VEVPLGT-----G-ISSGVNDT---C G_gallus_ENSGALP00000007181 KGIYF------------------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000108098 KGIYFASEN--SKSAGYVTTM-HC---GGHQVGYMFLGEVALGKEHHITI-----DDPSLKS--PPSGFDSVIARGQTEPDPAQDIELELDGQPVVVPQGP-----PVQCPSFKSS---S M_mulatta_ENSMMUP00000029228 KGIYFASEN--SKSAGYVTGM-NC---GAHHIGYMFLGEVALGREHHITT-----DKPSLKS--PPPGFDSVIARGHTEPDPTQDTELELDGQRVVVPQGQ-----PVPCPEFSSS---T T_guttata_ENSTGUP00000006583 KGIYFASEN--SKSACYVPGIVGC---TSKNVGIMFLTEVALGKPYRITC-----DDPTLCQ--PPAGYDSVLACGRTEPDPAQDEEVLLDGKKVLVCQDK-----PIPMPAYKDS---S G_gorilla_ENSGGOP00000006181 KGIYFADMV--SKSANYCHTS------QGDPIGLILLGEVALGNMYELKH-----ASH-ISK--LPKGKHSVKXXXXXXXXXXXX-XXX-XX--XXXXXXX-----X-XXXXXXXX---X T_nigroviridis_ENSTNIP00000017650 ------------------------------------------------------------------------------------------------------------------------ C_elegans_E02H1.4 NGVYFANVP--TKSANYCCPE------ASKRV-FMLLCEVETANPLVLYE-----SEIDADEKMEKAKKTSVYAAGKHTPRDTVE----ING----IPAFK-----SNLETIEEET---R T_nigroviridis_ENSTNIP00000000045 RGIYFASEN--SKSAGYALAV-R----TSKNTGVMFLCEVALGKENTITK-----DNPSLKK--APAGFDSVVARGSVEPDPTKDTFITLNGRKVWVPQGK-----PVDQPQYADS---H C_elegans_ZK1005.1a SGIYLADSF--EKSTHYCQPS-------AGGINYMLVCQTALGKVRTLDTIPYHYMNQSSSS--AEKYEDTLHYIGDRFPAGSLT----NDG--VGMPLLPLRKRDPIQGSNYGFG---T H_sapiens_ENSP00000371419 SGIYFSDSL--STSIKYSHPG------ETDGTRLLLICDVALGKCMDLHE-----KDFSLTE--APPGYDSVHGVSQTASVTT------------------------------------D P_troglodytes_ENSPTRP00000009733 SGIYFSDSL--STSIKYSHPG------GTDGTRLLLICDVALGKCMDLHE-----KNFSLTE--APPGYDSVHGVSQTASVTT------------------------------------D M_musculus_ENSMUSP00000066130 SGIYFSDSL--STSIKYAHAG------ETDGSRLLVVCDVALGKCVNLFK-----KDFSLTE--APPGYDSVHGVSETTSVPT------------------------------------D G_aculeatus_ENSGACP00000011271 SGIYFSDAV--STSLKYSKPS------ETDGSRLLLVCDVALGRCKDEHK-----GDVTLTR--APEGHHSVHGVRRGPNAPS------------------------------------E T_rubripes_ENSTRUP00000000233 SGIYFSDAF--STSLKYSQPS------ATDGSRLLLVCDVALGQCMDVSQ-----RDPTLTE--APQGFHSVHGVRGTPAAPS------------------------------------E C_familiaris_ENSCAFP00000010963 SGIYFSDSL--STSVKYSHSG------EIDGSRLLVVCDVALGKCMDLKK-----RDFSLTE--APPGYDSVHGVQTTATVTT------------------------------------D B_taurus_ENSBTAP00000035522 SGIYFSDSI--STSIKYSHPG------QTDGARLLVVCDVALGRCMDLHK-----RDFSLTE--APPEYDSVHGVRGTDMVSS------------------------------------D X_tropicalis_ENSXETP00000043695 SGIYFSDSI--STSVKYSEPS------VTNGARLLLVCEVALGNCKDLYK-----RDFSLTG--APSGFNSVHGVRQMPGRKS------------------------------------D T_nigroviridis_ENSTNIP00000004824 SGIYFSDAF--STSLKYSHPG------ATDGSRLLLVCDVALGRCQDVRK-----RDRTLSQ--APDGYHSVHGVRSAPGAPS------------------------------------E E_caballus_ENSECAP00000007671 SGIYFSNAL--STSTKYSHPG------ETDGTRLLVICEVALGKCMDLHK-----KDFSLVE--APPGYDSVHGVPGTATVPT------------------------------------D A_carolinensis_ENSACAP00000001773 SGIYFSDSL--STSIKYSQTS------KTDGARLFLICDVALGTCWNTHQ-----TNFSLTA--PPPGYDSVHGVSKKKDRKS------------------------------------A G_gallus_ENSGALP00000027638 SGIYFSDSVRYSASVKYSSPS------EMDGTRLLAVCDVALGSCLDLYE-----RDFSLNA--APLGYNSVHGVRKTADVSS------------------------------------D M_domestica_ENSMODP00000009821 SGIYFSDSL--STSIKYTQPT------QTDGTRFLVVCDVALGSCMNMHK-----KDFSLTE--PPPGYDSVHGIQKTEHVIS------------------------------------D O_cuniculus_ENSOCUP00000012495 SGIYFSDSL--SASIKYSHPG------ETEGTRVLVVCDVALGECIEFHK-----KDLSLTE--APHGYHSVHGVSRTASLNT------------------------------------D 2410 2420 2430 2440 2450 2460 2470 2480 2490 2500 2510 2520 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 LNYNEFIVYSPNQVRMRYLLKIQFNFLQ-------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000011840 LNYNEFIVYSPSQVHMRYLLKIQFNFLQ-------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000008035 LNYNEFIVYSPNQVRMRYLLKVRFNFLQ-------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000012338 LNYNEFIVYNPNQVRMRYLLKVQFNFLQ-------------------------------------------------------------------------------------------- H_sapiens_ENSP00000250416 LNYNEYIVYNPNQVRMRYLLKVQFNFLQ-------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000010339 LNYNEYIVYNPNQVRMRYLLKVQFNFLQ-------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000006331 LNYNEYIVYNPNQVRMRYLLKVQFNFLQ-------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000004152 LNYNEFIVYSPNQVRMRYLLKIRFNFLQ-------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000021361 LNYNEYIVYNPNQVRMRYLLKVQFNFLQ-------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000001988 LNYNEFIVYNPNQVRMRYLLKVQFNFLQ-------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000008892 LNYNEFIVYNTSQVRMRYLLKIRFNFTQ-------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000008175 LNYNEFIVYDPRQVRMKYLLKVRFNFTQ-------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000003642 LNYNEYIVYDPHQVRMKYLLQVHFNYSS-------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000003778 LLYNEFIVYSPAQTRMRYLLRIQFNYSS-------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000023516 LLYNEFIVYNPAQTRMRYLLRIKFNYSS-------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000006847 LLYNEFVIYNPAQIRMRYLLRIKFNYSS-------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000027488 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000018492 LLYNEFVVYSAKQVRPRFLVKLNFNFTQ-------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000011691 LWYNEFIVYDVAQIKPRFLVKLKFNYKT-------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000014960 LLYNEYIVYDVAQVNMKYLLKIKFNYQTS------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000019481 LLYNEYIVYDVAQINLKYLLKVRFNYQTS------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000017176 LLYNEYIVYDVAQINLKYLLKIKFNYQTS------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000008364 LLYNEYIVYDVSQVNLKYLLKIRFNYQTS------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000006218 LLYNEYIVYDIAQVNLKYLLKLDFKYKTS------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000037062 LLYNEYIVYDVAQINLKYLLKVRFNYQTS------------------------------------------------------------------------------------------- D_melanogaster_FBpp0112609 LLYNEYIVYDVAQVNIQYLFRMEFKYSY-------------------------------------------------------------------------------------------- H_sapiens_ENSP00000355759 LLYNEYIVYDIAQVNLKYLLKLKFNFKTS------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000027777 LLYNEYIVYDIAQVNLKYLLKLKFNFKTS------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000000162 LLYNEYIVYDIAQVNLKYLLKLKFNFKTS------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000023715 LLYNEYIVYDIAQVNLKYLLKLKFNFKTS------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000004232 LLYNEYIVYDIAQVNLKYLLKLKFNFKTS------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000001113 LLYNEYIVYDIAQVHLKYLLKLKFNFKTS------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000017400 LLYNEYIVYDIAQVNLKYLLKLKFNFKTS------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000028737 LLYNEYIVYDIAQVNLKYLLKLKFNFKTS------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000002367 LLYNEYIVYDIAQVNLKYLLKLKFNFKTS------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000007535 LLYNEYIIYDIAQVNLKYLLKLKFNFKSS------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000003457 LLYNEYIVYDIAQVNLKYLLKLKFNFKTS------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000048934 LLYNEYIVYDVAQVNLKYLLKLKFNYKDKGGL---------------------------------------------------------------------------------------- A_aegypti_AAEL011815-PA LLYNEYIVYDVAQVNCQYLFKMNFKYK--------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000004425 LLYNEYIVYDVAQVNLKYLLKLKFNYKTS------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000038037 LLYNEYIVYDVAQVNLKYLLKLKFNYKTS------------------------------------------------------------------------------------------- A_gambiae_AGAP003230-PA LLYNEFIVYDVGQVNCQYLFKMNFKYK--------------------------------------------------------------------------------------------- C_elegans_Y71F9AL.18.1 LLYNEFIVYDVDQIQLKYLVRVKMHHAR-------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000011424 FSQSEYLIYQESQCRIRYLIQFHF------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005989 FSNSEYLIYKESQCRLRYLLELKM------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000000153 FGQSEYLVYKESQARMRYLLLLKF------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000026625 FYNSEYLIYKESQCRIRYLLELKFNYY--------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000014791 FWQSEYLIYQESQCRLRYLLQLHF------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000001175 FSNSEYLIYKESQCRLRYLLELNIN----------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000000924 FCNSEYLIYKESQCRLRFLLELKM------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015470 FSQSEYLIYQESQCRLRYLLEVHL------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381740 FSQSEYLIYQESQCRLRYLLEVHL------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025859 FSQSEYLIYQESQCRLRYLLEVHL------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000043156 FSQSEYLIYQESQRCLRYLLEIHL------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000016262 FLQSEYLIYQESQCRLRYLLEVRL------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000012158 FSQSEYLIYQESQCHLRYLLEVHL------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014771 FFQSEYLIYQESQCHLRYLLEVHL------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000017224 FSQSEYLIYKESQCRLRYLLEIHL------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000015305 LLYNEYIVYDIAQVNLKYLLKLKFNFKTS------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000007181 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108098 FSQSEYLIYKESQCRLRYLLEIHL------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029228 FSQSEYLIYQESQCRLRYLLEVRL------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006583 FSQSEYLIYKESQCWIRYLVQLRF------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006181 XXXXXYIVYDIAQVNLKYLLKLKFNFKTS------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000017650 ------------------------------------------------------------------------------------------------------------------------ C_elegans_E02H1.4 LLYDEYVMFNKEHFKIKYVVEVKVDRLTAK------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000000045 FSNSEYLIYKESQCRIRYLLELQMH----------------------------------------------------------------------------------------------- C_elegans_ZK1005.1a LDFSEYIVRNPNRVLPKYIVMYK------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000371419 FEDDEFVVYKTNQVKMKYIIKFSMPGDQIKDFHPSDHTELEEYRPEFSN--FSKVEDYQL-PDAKTSSSTKAGLQDASGNLVPLEDVHIKGRIIDTVAQVIVFQTYTNKSHVPIEAKYIF P_troglodytes_ENSPTRP00000009733 FEDDEFVVYKTNQVKMKYIVKFSMPGDQIKDFHPSDHTELEEYRPEFSN--FSKVEDYQL-PDAKTSSSTKAGLQDASGNLVPLEDVHIKGRIIDTVAQVIVFQTYTNKSHMPIEAKYVF M_musculus_ENSMUSP00000066130 FQDDEFVVYKTNQVKMKYIVKFCTPGDQIKEFHPHENTEVEEQRAEPSS--VPEAGDFQL-PDIKPFTNIKAGLQDASANPVPLDSVHIKGRVIDFVAQVIVFQTYTNQSHVPIEAKYIF G_aculeatus_ENSGACP00000011271 FEDDEYVVYSPDQVKLKYVVQFAVEGDRLKEFSPAIDTSAQPAPPSCDR--AGWDDEEDVGSIRNPLAEAKAGLLDGSGQQLPLRAVHVRCKLMDLLSQVVVFQEYTNRGSAPIEAKYVF T_rubripes_ENSTRUP00000000233 FEDDEYVVYSPDQVRLKYVVQFCMEGDRLKEFSPTISTTAEPCLPSTVQ--ELRSEDVEV--VKDPLEDVKSGLLDSSGQQIPLQAVHVKCKLMDLLCQVIVFQKYTNDRPVPIEAKYVF C_familiaris_ENSCAFP00000010963 FEDDEFVVYKTNQIKMKYIIKFCIPGDEVKDFHPCNTTELEEYRPEFSN--SSNVEDYQL-ADTKPFSNIKSGLQDFSGNSVPLENVHIKGKIIDIIAQVIVFQTYTNQSSVPIEARYIF B_taurus_ENSBTAP00000035522 FEDDEFVVYKTNQVKMKYLVKFSVPGDEIKDFHPCDNTELEEDRPEFSN--FSAVEDHQL-PGSTPFPDIKAGLQDASGNSVPLEDVHIKGKIIDFVAQVIVFQTYTNQSHVPIEAKYVF X_tropicalis_ENSXETP00000043695 FEDDEFVVYKKDQIKMRYAVQFCTDKDQVNMERDKLSVQFEPMEEDVGEE-PVQVEDLML-ENLPEPQSINGGLQSVHGNQIPLENIHVKGKMMDLVAEVILFQTYINKSSVPIEAKYVF T_nigroviridis_ENSTNIP00000004824 FEDDEYVVYSPGQVRLKYVVRFSMEGDQLKEFSPSVSTSAQPLPPPAVQ--ELQSEEAEV--VKNPVEDVKAGLLDSSGQQVPLQAVHVRCKLMDLLSQVTIFQKYTNQRPEPIEAKFVF E_caballus_ENSECAP00000007671 FEDDEFVVYKTNQVKMKYIVKFCIAGDEIKDFHPCDSTELEEQRPEFSN--FSKVEDYQL-PDSKPFSNIKSGLQDASGNSVPLEDVHIKGKIIDFVAQVIVFQTYTNQNPVPIEAKYVF A_carolinensis_ENSACAP00000001773 FEGDEFVVYRTSQVRIRYVVKFSLVHDKVKEFHPVIRTELEDELPSLDQ---PQPEDYEM-PNQDKREKVISGLLDRSGNPIPLKNLHIKGKIIDFAGQIVIFQTYENQTDSPIEAKYVF G_gallus_ENSGALP00000027638 FEDDEFVVYKTTQVKIRYVVKFCLAEDQIKQFQPGTGVEIEQDNTEPESQCHLQNESYEL-PSANISDTVKTGLQDRLGNPVPLESVHIKARIIDFVAQVVMFQTYTNQNSSPIEAKYVF M_domestica_ENSMODP00000009821 FEDDEFVVYKTSQIKMKYLVKFCISGDRVKDFSPCAVTEWEENRPELLND-HTQLEDYTL-PDTDPFINIKAGLQDVSGIPIPLEEIHIKGRIMDFVAQIIVFQTYTNKSHLPIETKFVF O_cuniculus_ENSOCUP00000012495 FEDDEFVVYKTNQIKMKYIIKFCLPGDQVKKFHPPENTELEEYRPMFSS--ISKAEXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2530 2540 2550 2560 2570 2580 2590 2600 2610 2620 2630 2640 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000011840 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008035 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000012338 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250416 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010339 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000006331 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000004152 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021361 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001988 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008892 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003642 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003778 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023516 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000006847 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000027488 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000018492 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011691 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000014960 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019481 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000017176 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008364 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000006218 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000037062 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0112609 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000355759 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000027777 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000000162 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000023715 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000004232 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001113 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017400 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000028737 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002367 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000007535 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000003457 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000048934 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL011815-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004425 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000038037 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP003230-PA ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y71F9AL.18.1 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011424 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005989 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000000153 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000026625 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000014791 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000001175 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000000924 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015470 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381740 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025859 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000043156 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000016262 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000012158 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014771 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000017224 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000015305 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000007181 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108098 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029228 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006583 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006181 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000017650 ------------------------------------------------------------------------------------------------------------------------ C_elegans_E02H1.4 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000000045 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK1005.1a ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000371419 PLDDKAAVCGFEAFINGKHIVGEIKEKEEAQQEYLEAVTQGHGAYLMSQDAPDVFTVSVGNLPPKAKVLIKITYITELSILGTVGVFFMPATVAPWQQDKALNENL-QDTVEKICIK-EI P_troglodytes_ENSPTRP00000009733 PLDDKAAVCGFEAFINGKHIVGEIKEKEEAQQEYREAVTQGHGAYLMSQDAPDVFTVSVGNLPPKAKVLIKITYITELSILGTVGVFFMPATVAPWQQDKALNENL-QDTVEKICIK-EI M_musculus_ENSMUSP00000066130 PLDDKAAVCGFEAFINGKHIVGEIKEKEEARQEYREAVSQGHGAYLMDQDTPDVFTVSVGNLPPRAKVLIKITYITELSIQSPVAIFFIPGTVAPWQQDKALNENL-QDTVETIRIK-EI G_aculeatus_ENSGACP00000011271 PLDDSAAVCGFEAFINGKHVVGQVKEKETARKEYKQAVEKGHGAYLMDQDAPDVFTISVGNLPPGASVLIKVTFVCELVVRDGSVLFSLPGSVAPWQEGAALNQTTQQVTVEKVCVMFEE T_rubripes_ENSTRUP00000000233 PLSDSAAVCGFEAFINGKHVVGQVKEKEAARREYRQAVERGHGAYLMDQDAPDVFTISVGNLPPAASVLIKVTFVSELMVKDGSVLFSLPGSVAPWQESAALNQTT-QVTMEKVCVADDA C_familiaris_ENSCAFP00000010963 PLDDKAAVCGFEAFINGKHIVGEVKEKEAAHREYREAISQGHGAYLMDQDTPDVFTVSVGNLPPKAKVLIKITYITELSIQGSKAVFFMPATVAPWQQDKVLNENIQQDTVEKISIK-KI B_taurus_ENSBTAP00000035522 PLDDKAAVCGFEAFINGKHVVGEIKEKEVAQREYRVAISQGHGAYLMDQDTPDIFTVSVGNLPPKAKVLVKITYITELSIQGACAVFFLPATVAPWQQDRALRENL-QDTVEKICIK-EI X_tropicalis_ENSXETP00000043695 PLDGTAAVCGFEAFINGKHVIGEVKEKEQAHKEYRAAISEGHGAYLMDQDAADVFTVSVGNLPPNATVIIKITYITELILEYGSVIFNIPGTVASWQKDKALKENT-QDTVEKVCVE-ES T_nigroviridis_ENSTNIP00000004824 PLSDSAAVCGFEAFINGKHVVGQVKEKETARKEYKQAVERGHGAYLMDQDAPDVFTISVGNLPPAATVLVKVTFVSELVVQGGSILFSLPGSVAPWQESAALNQTT-QVTLEKVCVTEEE E_caballus_ENSECAP00000007671 PLDDKAAVCGFEAFINGKHIVGEVEEKEKAHREYRTAISQGHGAYLMDQDAPDVFTVSVGNLPPKAKILIKITYITELSIQGTTAVFFMPATVAPWRQDKALNENI-QDTVEKICIK-EI A_carolinensis_ENSACAP00000001773 PLDDTAAVCGFEAFIKGKHIIGEVKEKEKAHKEYRDAVIQGHGAYLMDQDAPDIFTVSVGNLPPSTKVLIKITYVTELNYDYGRFSFHLPAALTPWQQDKALNENT-QELTPTRAGF-EL G_gallus_ENSGALP00000027638 PLDDKAAVCGFEAFVNGRHIIGQVKEKKQAHREYRKAISEGDGAYLMDQDAPDIFVITVGNICPNSTVLIKVTYITELSCLNGCITFHMPASVSPWQQDKALNENT-QDTIKKICVK-QV M_domestica_ENSMODP00000009821 PLDDKAAVCGFEAFINGKHIIGEVKEKEEAHQEYREAIKQGHGAYLMDQDTPDVFTVSIGNLPPQAKVLIKITYITELSFHHGCASFFMPATVVPWQQDKVLNENL-QDTVEKVCIK-EV O_cuniculus_ENSOCUP00000012495 XXXXXXXXXXXXXXXXXXXXXXXIKEKEEAQREYREAISEGHGAYLMDQDAPDIFTVSVGNLPPKAKVLIKITYITELSLQGPVAVFFMPATVAPWQQDKALNENL-QDTVAKVCVK-EI 2650 2660 2670 2680 2690 2700 2710 2720 2730 2740 2750 2760 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 ---------------------------------------------------------------------------LW------------------------------------------- R_norvegicus_ENSRNOP00000011840 ---------------------------------------------------------------------------LW------------------------------------------- C_familiaris_ENSCAFP00000008035 ---------------------------------------------------------------------------LW------------------------------------------- B_taurus_ENSBTAP00000012338 ---------------------------------------------------------------------------LW------------------------------------------- H_sapiens_ENSP00000250416 ---------------------------------------------------------------------------LW------------------------------------------- P_troglodytes_ENSPTRP00000010339 ---------------------------------------------------------------------------LW------------------------------------------- P_pygmaeus_ENSPPYP00000006331 ---------------------------------------------------------------------------LW------------------------------------------- E_caballus_ENSECAP00000004152 ---------------------------------------------------------------------------LW------------------------------------------- M_mulatta_ENSMMUP00000021361 ---------------------------------------------------------------------------LW------------------------------------------- O_cuniculus_ENSOCUP00000001988 ---------------------------------------------------------------------------LW------------------------------------------- M_domestica_ENSMODP00000008892 ---------------------------------------------------------------------------LW------------------------------------------- A_carolinensis_ENSACAP00000008175 ---------------------------------------------------------------------------LW------------------------------------------- X_tropicalis_ENSXETP00000003642 ---------------------------------------------------------------------------LW------------------------------------------- O_latipes_ENSORLP00000003778 ---------------------------------------------------------------------------LW------------------------------------------- G_aculeatus_ENSGACP00000023516 ---------------------------------------------------------------------------LW------------------------------------------- T_nigroviridis_ENSTNIP00000006847 ---------------------------------------------------------------------------LW------------------------------------------- T_rubripes_ENSTRUP00000027488 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000018492 ---------------------------------------------------------------------------SW------------------------------------------- C_intestinalis_ENSCINP00000011691 ---------------------------------------------------------------------------GF------------------------------------------- G_aculeatus_ENSGACP00000014960 ---------------------------------------------------------------------------LW------------------------------------------- T_nigroviridis_ENSTNIP00000019481 ---------------------------------------------------------------------------LW------------------------------------------- O_latipes_ENSORLP00000017176 ---------------------------------------------------------------------------LW------------------------------------------- D_rerio_ENSDARP00000008364 ---------------------------------------------------------------------------LW------------------------------------------- A_carolinensis_ENSACAP00000006218 ---------------------------------------------------------------------------LW------------------------------------------- T_rubripes_ENSTRUP00000037062 ---------------------------------------------------------------------------LW------------------------------------------- D_melanogaster_FBpp0112609 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000355759 ---------------------------------------------------------------------------LW------------------------------------------- M_musculus_ENSMUSP00000027777 ---------------------------------------------------------------------------LW------------------------------------------- P_pygmaeus_ENSPPYP00000000162 ---------------------------------------------------------------------------LW------------------------------------------- C_familiaris_ENSCAFP00000023715 ---------------------------------------------------------------------------LW------------------------------------------- R_norvegicus_ENSRNOP00000004232 ---------------------------------------------------------------------------LW------------------------------------------- B_taurus_ENSBTAP00000001113 ---------------------------------------------------------------------------LW------------------------------------------- E_caballus_ENSECAP00000017400 ---------------------------------------------------------------------------LW------------------------------------------- M_mulatta_ENSMMUP00000028737 ---------------------------------------------------------------------------LW------------------------------------------- O_anatinus_ENSOANP00000002367 ---------------------------------------------------------------------------LW------------------------------------------- M_domestica_ENSMODP00000007535 ---------------------------------------------------------------------------LW------------------------------------------- P_troglodytes_ENSPTRP00000003457 ---------------------------------------------------------------------------LW------------------------------------------- X_tropicalis_ENSXETP00000048934 ---------------------------------------------------------------------------LW------------------------------------------- A_aegypti_AAEL011815-PA ----------------------------------------------------------------------------Y------------------------------------------- T_guttata_ENSTGUP00000004425 ---------------------------------------------------------------------------LW------------------------------------------- G_gallus_ENSGALP00000038037 ---------------------------------------------------------------------------LW------------------------------------------- A_gambiae_AGAP003230-PA ----------------------------------------------------------------------------Y------------------------------------------- C_elegans_Y71F9AL.18.1 ---------------------------------------------------------------------------HL------------------------------------------- A_carolinensis_ENSACAP00000011424 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005989 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000000153 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000026625 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000014791 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000001175 ---------------------------------------------------------------------------AY------------------------------------------- O_latipes_ENSORLP00000000924 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015470 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381740 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025859 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000043156 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000016262 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000012158 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014771 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000017224 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000015305 ---------------------------------------------------------------------------LW------------------------------------------- G_gallus_ENSGALP00000007181 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108098 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029228 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006583 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006181 ---------------------------------------------------------------------------LW------------------------------------------- T_nigroviridis_ENSTNIP00000017650 ------------------------------------------------------------------------------------------------------------------------ C_elegans_E02H1.4 -------------------------------------------------------------------------EMMA------------------------------------------- T_nigroviridis_ENSTNIP00000000045 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK1005.1a ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000371419 GTKQSFSLTMSIEMPYVIEFIFSDTHELKQKRTDCKAVISTMEG----SSLDSSGFSLHIGLSAAYL------PRMWVEKHPEKESEACMLVFQPDLDVDLPDLASESEVIICLDCSSSM P_troglodytes_ENSPTRP00000009733 GTKQSFSLTMSIEMPYVIEFIFSDTHELKQKRTDCKAVISTMEG----SSLDSSGFSLHIGLSAAYL------PRMWVEKHPEKESEACMLVFQPDLNVDLPDLANESEVIICLDCSSSM M_musculus_ENSMUSP00000066130 GAEQSFSLAMSIEMPYMIEFISSDTHELRQKSTDCKAVVSTVEG----SSLDSGGFSLHIGLRDAYL------PRMWVEKHPEKESEACMLVFQPELADVLPDLRGKNEVIICLDCSSSM G_aculeatus_ENSGACP00000011271 --DREFTLDMSVEMPNKITDLQCITHRVRIKRTDCKAVVSVLPG----ELMGVDGFQLSITLSEVHL------PRMWVEKHPDKDSQACMLVFYPDFEVESSS-AP-DEVVLLVDSSESM T_rubripes_ENSTRUP00000000233 AGSREFSLDASVQMPNQISSLGCITHRVKVKRTDCKAVVSVLPG----QVLGPEGFQLSVRLAEVHL------PRMWVEKHPEKESQACMLVFYPDFDISSGS-PSSNEVVLLLDTSESM C_familiaris_ENSCAFP00000010963 GTKQSFSLSMSIEMPYMIESISSDTHELRQKRTDCKAVISTVEG----SSLDSDGFTLHVGLSDAYL------PRMWVEKHPEKESEACMLIFQPNLNITLPDLTKNNEVIICLDCSNSM B_taurus_ENSBTAP00000035522 GAKQSFSLSMSIEMPHMIEFISSDTHDLRKKRTDCKAVISTVEG----SSLDSNGFSLLIGLVDVYL------PRMWVEKHPEKESEACMLVFQPNLGITVPDEAERSEVIICLDCSNSM X_tropicalis_ENSXETP00000043695 GVPQGYSF---VRSPPKTCSVCSF-----LQLNDLKGIADRLECFFPLQRLDDEGFQLRVYLESSFLESSWNQPRMWVEKHPKEDSEACMLVFLPSFKTSI----QSWDLTILLDCSNSM T_nigroviridis_ENSTNIP00000004824 AASREFTLDACVEMPHEISRLTCLTHSVKTKRTDCKAVVSVLPG----QILGPEGFQLSVSLSKAHL------PRMWVEKHPEKDSQACMLVFYPDFDIDAGS-PPSNEVVLLLDTSESM E_caballus_ENSECAP00000007671 GAQQSFSLSMSIEMPYVIEFISSDTHELRQKSTDCKAVISTVEG----SSLDSSGFSLHIGLSDAYL------PRMWVEKHPEKESEACMLVFQPDLDIALPDLAEKSEVVICLDCSNSM A_carolinensis_ENSACAP00000001773 MTSFEFSLQMSVEMPFKIESIRSWTHELKIKKTDCKAVVCTKDA----SSLGMEGFTMDIVNGNVYL------PRMWIEKHPDKKSEACMLVFQPEFDTPFDPIHTSGETVICLDCSNSM G_gallus_ENSGALP00000027638 ETLKKFSLDMSIEMPYSIESIHSWTHKLKIKKTECKAVIKTVEN----SSLDSSGFGLDIWISHAYL------PRMWVEKHPNKNSEACMLVFQPEFEAAFDEEQLSSEIIILLDCSNSM M_domestica_ENSMODP00000009821 GMQQRFFLNMSIEMPHVIELITSDTHKLKIKKTDCKAVISTLDN----SSLDSKGFSLQIHIGDAYL------PRMWVEKHPNKKSEACMLVFHPDFSTELPERSQTSEVIICLDCSNSM O_cuniculus_ENSOCUP00000012495 GKQQSFSLTMSIEMPYVIKSISSDTHKLKQKXXXXXXXXXXXXX----XXXXXXXXXXXXXXXXXXX------XXXXXXXXXXXXXXACMLVFQPHLAATLPELAVKSEVIICLDCSNSM 2770 2780 2790 2800 2810 2820 2830 2840 2850 2860 2870 2880 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000011840 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008035 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000012338 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250416 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010339 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000006331 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000004152 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021361 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001988 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008892 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003642 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003778 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023516 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000006847 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000027488 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000018492 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011691 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000014960 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019481 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000017176 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008364 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000006218 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000037062 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0112609 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000355759 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000027777 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000000162 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000023715 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000004232 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001113 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017400 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000028737 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002367 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000007535 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000003457 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000048934 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL011815-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004425 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000038037 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP003230-PA ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y71F9AL.18.1 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011424 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005989 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000000153 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000026625 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000014791 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000001175 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000000924 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015470 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381740 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025859 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000043156 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000016262 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000012158 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014771 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000017224 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000015305 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000007181 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108098 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029228 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006583 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006181 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000017650 ------------------------------------------------------------------------------------------------------------------------ C_elegans_E02H1.4 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000000045 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK1005.1a ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000371419 EGVTFLQAKQIALHALSLVGEKQKVNIIQFGTGYKELFSYPKHITSN-TMAAEFIMSATPTMGNTDFWKTLRYLSLLYPARGSRNILLVSDGHLQDESLTLQLVKRSRPHTRLF--ACGI P_troglodytes_ENSPTRP00000009733 EGVTFLQAKQIALHALSLVGEKQKVNIIQFGTGYKELFSYPKHMTSN-TAAAEFIMSATPTMGNTDFWKTLRYLSLLYPARGSRNILLVSDGHLQDESLTLQLVKRSRPHTRLF--ACGI M_musculus_ENSMUSP00000066130 EGVTFTQAKQVALYALSLLGEEQKVNIMQFGTGYKELFSYPKCITDS-KMATEFIMSAAPSMGNTDFWKVLRYLSLLYPSEGFRNILLISDGHLQSESLTLQLVKRNIQHTRVF--TCAV G_aculeatus_ENSGACP00000011271 KGEPLLAARRIALQVLKTLGSHLRVNVLFFGTDHTEAFPTARPLGDARADAEVVVKLAPPVGGGTELWRPLRALGLLPPSRGVRNLLLLSDGHVQNAELALRLLRDGAGRSRLF--ACGL T_rubripes_ENSTRUP00000000233 -GDVLQAVQEIALRVLKALHRDLKVNIILFGTGQFDLF--SQPLGDVYEEAKSFIKRFTPVGGSTELWRPLRALGLLPPSRGIRNLLLLSDGHIQNPELTLQLLRDGVQHSRLF--ACGL C_familiaris_ENSCAFP00000010963 EGATFLQAKQIALYALSLMGKKQKINIVKFGTDYTELFSYPKYIASN-NMLTEFIMSATPTMGNTDFWKTLRYLNLLYPSQGLRSILLISDGHLQNESLTLQLVKRNVQHTRLF--SCGI B_taurus_ENSBTAP00000035522 EGETFLQAKQIALHALSCVGKEQKVNVIKFGTSYKELFSYPKCITSN-KMPTEFIMSATPTMGNTDFWKTLRYLNLLYPSHVLRNILLISDGHLQNESLTLQLVRRSVPHTRLF--SCGV X_tropicalis_ENSXETP00000043695 E-STFQSAKRIALLAASSLNPWHNINIISFGTGKYKHYVQRERALLP-QSSIKPLLMAKPNMGNTELWKPLQSLCLLAPPSDMHNVLLISDGHIQNESLVFQILKKNAGKVRLF--TCGV T_nigroviridis_ENSTNIP00000004824 R-DSLHTLQEIALRVLKALHPDVKVNIILFGTDHSEAFLTARPLGEAEGEVKSFVKRFTPVGGSTELWRPLRALSLLPPSRGLRNLLLLSDGHVQNPELTLQLLRDGVQHSRLFPAASGL E_caballus_ENSECAP00000007671 ESVPFLQAKQIALYALSLVGKKQKINIVKFGTGYQELFSYPKHVTSN-SMPAEFIMSASPTMGNTDFWKTLRYLNLLYPSQGLRNILLISDGHLQNESLTLQLVRRNVQHTRLF--SCGV A_carolinensis_ENSACAP00000001773 AGSKIQHAKQIALSYLNSCYDTEKLTVIKFGTSKTLFFFWKSFKR---SVKCIFKMSATATMGNSDFWKTLHYLSLLYPSKGKRNILFISDGHIQNEAVTLQLVKQNAKHTRIF--TCGV G_gallus_ENSGALP00000027638 AGSALLQAKQIALHALKQFSSRQNVNLIKFGTNFSEFSSFSKNTSKDLASLTEFITSATATMGNTDLWKTLRYLSLLFPSQGHRNILLISDGHIQNESVTFQLVKDNVHHTRLF--TCGV M_domestica_ENSMODP00000009821 EGSEFLQAKQIALHALSLVHEKQKVNIIKFGTNYTELFSYPKYSTSN-PKLTEFIMSATPTMGNTDFWKTLRFLSLLYPSQGMRNILLLSDGHIQNESLTLQIVKRNVRHTRLF--ACGI O_cuniculus_ENSOCUP00000012495 EGVTFRQAKQIALHALSLVGEKQKVNVVQFGTGYKELFSYPKHIASN-NAPTEFILSATPILGNTDFRKILR-LSLLYPVLWLRNSFLISDGHRQSVSLTLQLVKRNLDQTRLF---CGV 2890 2900 2910 2920 2930 2940 2950 2960 2970 2980 2990 3000 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000011840 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008035 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000012338 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250416 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010339 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000006331 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000004152 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021361 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001988 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008892 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003642 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003778 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023516 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000006847 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000027488 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000018492 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011691 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000014960 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019481 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000017176 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008364 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000006218 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000037062 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0112609 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000355759 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000027777 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000000162 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000023715 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000004232 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001113 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017400 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000028737 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002367 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000007535 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000003457 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000048934 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL011815-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004425 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000038037 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP003230-PA ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y71F9AL.18.1 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011424 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005989 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000000153 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000026625 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000014791 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000001175 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000000924 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015470 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381740 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025859 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000043156 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000016262 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000012158 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014771 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000017224 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000015305 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000007181 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108098 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029228 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006583 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006181 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000017650 ------------------------------------------------------------------------------------------------------------------------ C_elegans_E02H1.4 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000000045 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK1005.1a ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000371419 -GSTANRHVLRILSQCGAGVFEYFNAKSKHSWRKQ-IEDQMTRLCSPSCHSVSVKWQQLNPDVPEALQAPAQVPSLFLNDRLLVYGFIPHCTQATLCALIQEKEFRTMVSTTELQKTTGT P_troglodytes_ENSPTRP00000009733 -GSTANRHILRILSQCGAGVFEYFNAKSKHSWRKQ-IEDQMTRLCSPSCHSVSVKWQQLNPDAPEALQAPAQVPSLFRNDRLLVYGFIPHCTQATLCALIQEKEFCTMVSTTELQKTTGT M_musculus_ENSMUSP00000066130 -GSTANRHILRTLSQCGAGVFEYFNSKSKHSWKKQ-IEAQMTRIRSPSCHSVSVKWQQLSRDAPEPLQAPAWVPSLFHNDRLLVYGFIPHCTQATLQAFIQEKEFCTMVSTTELQKTTGT G_aculeatus_ENSGACP00000011271 -SPTANRHMLRALAQAGGGAYEFFDTKTKHNWAEKQVARQVKRMASPGCSSVAVKWQQFSPTAASPVQAPRQLPALFNDCHALVYGFVPHCTQATLRGNLSGQELNTMVSTSELQKTRGT T_rubripes_ENSTRUP00000000233 -SPTANRHMLRALAQAGGGAFEFFDTKTKHTWTEK-AARQVKRMAAPGCSSVSVKWQQFSPTAPPPVQAPQQLHALFSDCHTLVYGFVPHCTQATLCGNLSGKELRTMVSTSELQKTRGT C_familiaris_ENSCAFP00000010963 -GSTANRHMLRTLSQYGAGVFEYFNSKSKHSWKKQ-IEDQMTRLHSPSCHSVSIKWQLLSTDAPEPLQAPAHVQSLFHNDRLLVYGFVPHCTQATLCALIQEKEFSTIVSTTELQKTTGT B_taurus_ENSBTAP00000035522 -SSTANRHVLRSLSHYGAGVFEYFNSKSKHSWKKQ-IEAQMDRLSSPSCHSVSVKWQQLSTDTPAPLQAPTQVQSLFHSERLLVYGLTPHCTQATLHALIQEREYSTVVSTTELQKTTGT X_tropicalis_ENSXETP00000043695 -GATANRHMLRCLAQYGAGFFEFFEDKSKTSWKKK-MEAQLERMDSPACTSASVKWMQFSDNDPEPVQAPAHIPALFNRSFLLVYGFAPRCTQAKLQALIDDDELDTMVSTTELQKTRGT T_nigroviridis_ENSTNIP00000004824 HGPTANRHMLRALAQAGGGAFEFFDTKSRHTWAEK-VACQVKRMAAPGCSSVSVKWQQFNPTAPPPVQAPKQLHALFRDCHTLVYGFVPHCTQATLLGSLSGKELRTMVSTSELQKTRGT E_caballus_ENSECAP00000007671 -GSTANHHILRILSQCGAGVFEYLNSKSKHSWKKQ-IEDQMTRLCSPSCHSVSVKWQQLSPDAPEPLQAPAQVQSLFHNDRLLVYGFIPHCTQATLYALIQEKEFSTMVSTTELQKTTGT A_carolinensis_ENSACAP00000001773 -GPAANRHMLRSLSQYGAGAFEYFDEKSKYDWERKASITQQKRRWSPECSAISIKWQQFDTDAPELMYAPAQIQSLFEHERLLVYGFISNCTQAALYALLNSQELQTIVSTTELQKTTGT G_gallus_ENSGALP00000027638 -GSTANRHMLRSLSQYGAGAFEYFDSKSKYNWEAK-IQNQVSRIFSPGCSSVSIKWQQFDINAPKPMQAPAQIQSLFTNERLLVYGFVPHCTQATLRAIINDQELQTVVSTTELQKTTGT M_domestica_ENSMODP00000009821 -GSTANRHILRALSQYGAGAFEYFNTKSKYSWKKQ-IEDQMTRIFSPGCSSVSVKWQQLTPNSPEPMQAPIQIQALFNNDRLLVYGFIPHCTQAILSALFQDREFQTMVSTTELQKTTGT O_cuniculus_ENSOCUP00000012495 ------------------------------------------------------------------------------------------------------------------------ 3010 3020 3030 3040 3050 3060 3070 3080 3090 3100 3110 3120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000011840 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008035 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000012338 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250416 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010339 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000006331 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000004152 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021361 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001988 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008892 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003642 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003778 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023516 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000006847 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000027488 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000018492 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011691 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000014960 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019481 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000017176 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008364 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000006218 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000037062 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0112609 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000355759 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000027777 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000000162 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000023715 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000004232 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001113 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017400 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000028737 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002367 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000007535 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000003457 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000048934 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL011815-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004425 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000038037 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP003230-PA ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y71F9AL.18.1 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011424 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005989 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000000153 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000026625 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000014791 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000001175 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000000924 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015470 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381740 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025859 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000043156 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000016262 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000012158 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014771 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000017224 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000015305 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000007181 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108098 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029228 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006583 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006181 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000017650 ------------------------------------------------------------------------------------------------------------------------ C_elegans_E02H1.4 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000000045 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK1005.1a ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000371419 MIHKLAARALIRDYEDGILHENETSHEMKKQTLKSLIIKLSKENSLITQFTSFVAVEKR-DENESPFPDIPKVSELIAKEDVDFLPYMSWQGEPQEAVRNQS-LLASSE---WPELRL-- P_troglodytes_ENSPTRP00000009733 MIHKLAARALIRDYEDGILHENETSHEMKKQTLKSLIIKLSKENSLITQFTSFVAVEKR-DENESPFPDIPKVSELIAKEDVDFLPYMSWQGEPQEAVRNQS-LLASSE---WPELRL-- M_musculus_ENSMUSP00000066130 MIHKLAARALIRDYEDGILHDDETNHEMKKNIMKSLIIELSKENSLITQFTSFVAVEKR-DVNEIPFANVPNISELVAKEDVDFLPYVSWQEKQPEASISQT-EIDSSR----------- G_aculeatus_ENSGACP00000011271 FLHKLTARALIRDHEDGSLDGDEAQHEGRKAELKRFIVELSKEFSILSQFTSFVAVEN-STQTEEGVTDIP---KLISEEDVDFLPYLDWTRTSPSED-----------------ESPVG T_rubripes_ENSTRUP00000000233 FLHKLTARAVIQDYEDGNLDADEAQHEGKKAELREFIVGLSKEFSILSQFTSFVAIEERGSAQEQGFTDIP---KLIAEEDVDFLPYISWSSPQTAADQDEE-EVEGAVYEELSSESLVG C_familiaris_ENSCAFP00000010963 MIHKLTAQGLIRDYEDGILHENETNHEMKKQILKSLIIKLSKENSLITQFTSFVAVEKR-DGKESPFLDIPNISELIAKEDIDFLPYIGWQEEQLEDSVAQV-NVNYQD--MTPKAKV-- B_taurus_ENSBTAP00000035522 MIHKLAARALIRDYEDGILHENEVNHEMKKQTLKSLIIKLSKENSLITQFTSFVAVEKR-YGNESPSPDIPNTLELIAKEDIDFLPYMSWEGEQPDASRMQT-LSASSEWNQEPKRKC-- X_tropicalis_ENSXETP00000043695 MLHKLTARAVIKDYEDGILHEKEHEHEMKKQQMKSFIIELSKKYSIVTQFTSFVAVEKR-DAQEKPKDYVPNVLEIISTEDVDILPYMMWETQEEDQAAVLQ------------------ T_nigroviridis_ENSTNIP00000004824 FLHKLTARAVIRDYEDGNLDADAAQHEGKKAELREFVISLSKEFSILSQFTSFVAVEERGSAQDEGFTDVP---KLIAEEDVDFLPYISWSSSQDMDMDRHM------------------ E_caballus_ENSECAP00000007671 MIHKLTARALIRDYEDGILHENERNHEMKKQVLKSLIIKLSKENCLLTQFTSFVAVEKR-DDNEAPFPNIPNILELIAKEDVDFLPYMSWQEEQPDASITQQPLSAFSEWIEEFQHKH-- A_carolinensis_ENSACAP00000001773 ILHKLAARAFIRDYEQGILHEDEAENEMKKQLLKSMIIKLSMENSIVTQFTSFVAIEKR-DEKEDQITDSLDVLELVSKENVDILPYM-------------------------------- G_gallus_ENSGALP00000027638 VLHKLTARAFIRDYEDGILHENETEHEMKKQILKNMIIHLSMENSIITQFTSFIAIEKR-DANEICSANVPNILEIIAQEDVDFLPYMNWEQKPMGSGTLFSGEPYGIPPFDLFFMKF-- M_domestica_ENSMODP00000009821 VRFKIS------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000012495 ------------------------------------------------------------------------------------------------------------------------ 3130 3140 3150 3160 3170 3180 3190 3200 3210 3220 3230 3240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000011840 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008035 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000012338 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250416 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010339 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000006331 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000004152 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021361 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001988 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008892 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003642 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003778 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023516 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000006847 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000027488 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000018492 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011691 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000014960 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019481 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000017176 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008364 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000006218 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000037062 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0112609 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000355759 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000027777 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000000162 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000023715 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000004232 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001113 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017400 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000028737 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002367 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000007535 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000003457 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000048934 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL011815-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004425 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000038037 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP003230-PA ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y71F9AL.18.1 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011424 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005989 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000000153 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000026625 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000014791 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000001175 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000000924 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015470 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381740 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025859 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000043156 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000016262 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000012158 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014771 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000017224 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000015305 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000007181 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108098 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029228 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006583 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006181 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000017650 ------------------------------------------------------------------------------------------------------------------------ C_elegans_E02H1.4 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000000045 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK1005.1a ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000371419 ------SKRKHRKIPFSKRKMELSQPEVSEDFE---------EDGLGVLPAFTSN-LERGGVEKLLDLSWTESCKPTATEPL--------------FKKVSPWETSTSSFFPILAP---- P_troglodytes_ENSPTRP00000009733 ------SKRKRRKIPFSKRKMELSQPEVSEDFE---------EDALGVLPAFTSN-LERGGVEKLLDLSWTESCKPTATEPL--------------FKKVSPWETSTSSFFPILAP---- M_musculus_ENSMUSP00000066130 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000011271 CCLSMPV------HHPLLTSLRHRI----NPFICEEKLVMFSFTEQTEYFLFTSL-LLQGAVCLKRRSERQKVREEVDSEEVSYCHPPASASS----SSYYPPPRPFGGSL-----LQPQ T_rubripes_ENSTRUP00000000233 LALDCSIQRGGAPHPPISRSLQFECASLAHAFICARPRRDFSRCLGSEALGGASR---FGGAPLPPVDAPLPPVPGALFNFAPLPPPPPAAPP----SRGAPPPPPASPPF--------L C_familiaris_ENSCAFP00000010963 ------KKRKNRAIGFHEKKFKLSRLEYSEDLDVLED-----FGSQLSEKPLIVN-FEHGDVEKPLDTRISESFKLPLCEAAPFLKPAGYSISAAHSSACLEVQPFFGTSFLHPPRLCHK B_taurus_ENSBTAP00000035522 ------KRKQTK------KKRSSLKMILSEDFKA--------FSSDAPEESEAVS-FVFRDAEEPWGLGLMESSKQTEVKPQ--------------FTEAISQKTAFSDIPTAPSFLTTP X_tropicalis_ENSXETP00000043695 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000004824 ------------DMLFMEEEYGSDSMDLGEPVLLESSRRD-----------------------RRNVTEGMAEIQDSLCDFFSPPTSPPVEEPCGIGAVQFSEPKPKSKAFSNLLFGHSF E_caballus_ENSECAP00000007671 ---------------LTKRKLKSSELEVFEDCEE--------VCLDSPLPEKPLSLFKCGGVEKPLDLSQMDSFKQTRIKST--------------STKSVSQKMAVSSSFAAPPPICLP A_carolinensis_ENSACAP00000001773 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000027638 ------------LQFLNYLERNKFHTGIVWNFNINTKIGGICLQNKVSFWESCKSLFVYLIMHNTSPFVFCQANFTTVSKESISQEVIPQDYGFHDDDIATVKFAAAMPFVPCKPFVMSY M_domestica_ENSMODP00000009821 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000012495 ------------------------------------------------------------------------------------------------------------------------ 3250 3260 3270 3280 3290 3300 3310 3320 3330 3340 3350 3360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000011840 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008035 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000012338 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250416 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010339 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000006331 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000004152 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021361 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001988 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008892 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003642 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003778 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023516 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000006847 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000027488 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000018492 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011691 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000014960 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019481 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000017176 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008364 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000006218 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000037062 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0112609 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000355759 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000027777 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000000162 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000023715 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000004232 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001113 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017400 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000028737 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002367 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000007535 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000003457 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000048934 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL011815-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004425 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000038037 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP003230-PA ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y71F9AL.18.1 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011424 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005989 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000000153 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000026625 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000014791 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000001175 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000000924 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015470 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381740 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025859 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000043156 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000016262 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000012158 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014771 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000017224 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000015305 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000007181 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108098 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029228 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006583 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006181 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000017650 ------------------------------------------------------------------------------------------------------------------------ C_elegans_E02H1.4 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000000045 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK1005.1a ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000371419 -----AVGSYLPPTARAHSPASLSFASYRQVASFGSAAPPRQFDASQFSQGPVPGTCADWIPQSASCPTGPPQNPPSSPYCGIVFSGSSLSSAQSAPLQHPGGFTTRPSAGTFPELDSPQ P_troglodytes_ENSPTRP00000009733 -----AVGSYLPPTARAHSPASLSFASYRQVASFGSAAPPRQFDASQFSQGPVPGSCADWIPQSASCPTGPPQNPPSAPYCGIVFSGSSLSSAQSAPPQPAGGHMTRPSAGTFPELDSPQ M_musculus_ENSMUSP00000066130 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000011271 SAALHVFG----ISLKNRQPAALLPPPP--RPFRGSCGEPQSAAL----HVLPPPPPRPFLG--SLGEPQPAAHHPIWPHYGSARSDLAFGSAFSGLQPVNQPAGSV---LIDSVEVRTP T_rubripes_ENSTRUP00000000233 GASLPLFSDTRLDSFIAKTVSTLAPPPPAAAPFRAPPLPPHAGALPPVDAPLPPVPGALFDF--APPPPPPPAAAP--PFRGAPLPSLA-----GALPPVDAPLPPVPGALFDFAPPPPP C_familiaris_ENSCAFP00000010963 KA---HFA--CPKSL-------------------------KQFGPSKNDQDLQIDFLGDFTPESRTPSRPPS--LRFGSSAFSSLLGASFKSREVNLPETSQSHKTDNSGSISHELDSLL B_taurus_ENSBTAP00000035522 LHVGSGFYLQASSAL------------------FGSPAGPKHFGSPK--KYLEMGSGADVSLDMASFPRLHLQG---SPLQLAAAPRVSFSSGS-QLPKTNQGGATGFSALTTLQPDPLS X_tropicalis_ENSXETP00000043695 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000004824 LAAQPFLRRFSPQSFSVPTCVGAAPAPH------AVPFSPFSFQILFGFCLCWCCSGSTCYQSLASAPPGFPLFAGLSPLSGSGVESLLDSPCVGAAPPPQ-------------AAPPPP E_caballus_ENSECAP00000007671 RAAPVHFTSLCPPTLPPQNSLS------------DSLASPKQLGPSPNDQGLETRTCTDVSFESRPLPRLSSQNLTFGSLAGSAFSGALFSSKQFDLPKTDPRHQIRRRASISLELDPPL A_carolinensis_ENSACAP00000001773 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000027638 CNTAPLFGSAVGAAYMTQKNSFPTPALASSGAHLRLCGSPVYSPPSPLVGMKYDNSFVDHIPNTIMFGSCASTYSSDKTNAEKQVTH--------------------------------- M_domestica_ENSMODP00000009821 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000012495 ------------------------------------------------------------------------------------------------------------------------ 3370 3380 3390 3400 3410 3420 3430 3440 3450 3460 3470 3480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000011840 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008035 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000012338 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250416 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010339 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000006331 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000004152 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021361 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001988 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008892 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003642 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003778 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023516 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000006847 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000027488 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000018492 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011691 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000014960 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019481 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000017176 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008364 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000006218 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000037062 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0112609 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000355759 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000027777 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000000162 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000023715 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000004232 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001113 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017400 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000028737 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002367 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000007535 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000003457 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000048934 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL011815-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004425 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000038037 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP003230-PA ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y71F9AL.18.1 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011424 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005989 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000000153 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000026625 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000014791 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000001175 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000000924 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015470 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381740 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025859 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000043156 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000016262 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000012158 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014771 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000017224 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000015305 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000007181 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108098 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029228 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006583 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006181 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000017650 ------------------------------------------------------------------------------------------------------------------------ C_elegans_E02H1.4 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000000045 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK1005.1a ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000371419 LHFSLPTDPDPI----------------------RGFGSYHPSA---SSPFHFQPSAASLTANLRLPMASALPEALCSQSRTTPVDL---------------------CLLEESVGSLEG P_troglodytes_ENSPTRP00000009733 LHFSVPTDPDPI----------------------RGFGSYHPSA---SSPFHFQPSAASLTANLRLPMASALPEALCSQSRTTPLDL---------------------CLLEESVGSLEG M_musculus_ENSMUSP00000066130 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000011271 WSSM-----GGV-------------------------------------EDEPQCPGER------LESDLETCFLATNLDSPSPDIS----------------------------SQQQQ T_rubripes_ENSTRUP00000000233 PPAAAPPFRGAP-------------------------------------PPSPSCCCSSIPWMLLLPLPLLLLLLHFAPSSPSPSCC---------------------CSSIPWMEQQQA C_familiaris_ENSCAFP00000010963 QPNIFLSLPKRV----------------SSASPSRGFDVHYHSD----SPLYFQNSVVPLSTSYKPPID--LF--ANTELESSSTDL---------------------SARISSP----- B_taurus_ENSBTAP00000035522 RPNLFSCSASLLPCPLVNFPPLSGGIAPPPPPLSQGVGIPPPPPPPLSSPLPSHHLPSLRSASYKLPVAPSGP----AEDARLDIPL---------------------LAVYDKPLSLDS X_tropicalis_ENSXETP00000043695 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000004824 PPAH---------------------------------------------HLSGQYCISHYGAFGALPPADVLPRHFPARDSARVANTEVLIKRGKFEGWFCGSLGTEEAAEVDWASRSSS E_caballus_ENSECAP00000007671 QQSPFSSSPILI-----------------------------FHDLSDSSPIHLQNTPAPLSASSKLPRG--LFDLAHNELGASPSNV---------------------SARAAPSDSLQR A_carolinensis_ENSACAP00000001773 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000027638 -----------------------------------------------NSPVPQHHKKTKLKAKYRKKMVTGLQDATASEQEFPERPK----------------------------RLVHC M_domestica_ENSMODP00000009821 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000012495 ------------------------------------------------------------------------------------------------------------------------ 3490 3500 3510 3520 3530 3540 3550 3560 3570 3580 3590 3600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000048877 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000011840 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008035 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000012338 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250416 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010339 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000006331 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000004152 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021361 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001988 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008892 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003642 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003778 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023516 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000006847 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000027488 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000018492 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011691 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000014960 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019481 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000017176 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008364 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000006218 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000037062 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0112609 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000355759 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000027777 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000000162 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000023715 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000004232 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001113 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017400 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000028737 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002367 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000007535 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000003457 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000048934 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL011815-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004425 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000038037 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP003230-PA ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y71F9AL.18.1 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011424 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005989 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000000153 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000026625 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000014791 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000001175 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000000924 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015470 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381740 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025859 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000043156 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000016262 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000012158 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014771 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000017224 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000015305 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000007181 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108098 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029228 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006583 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006181 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000017650 ------------------------------------------------------------------------------------------------------------------------ C_elegans_E02H1.4 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000000045 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK1005.1a ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000371419 SRCPVFAFQSS-DTESDELSEVLQDSCFLQIKCD--TKDDSILCFLEVKEEDEIVCIQHWQDAVPWTELLSLQTEDGFWKLTPELGLILNLNTN-GLHSFLKQKGIQSLGVKGRECLLDL P_troglodytes_ENSPTRP00000009733 SRCPVFAFQSS-DTESDELSEVLQDSCFLQIKCD--TKDDSILCFLEVKEEDEIVCTQHWQDAVPWTELLSLQTEDGFWKLTPELGLILNLNTN-GLHSFLKQKGIQSLGVKGRERLLDI M_musculus_ENSMUSP00000066130 --------------------------------------------------------------------LKHNKLSDGHGVLQP-----------------------VSVSSEVNEKPSLL G_aculeatus_ENSGACP00000011271 LRVLADSVQSPKKKLFKQVEARSRRLASLIAGPEQSYLGSSCDGSMAEFPSLKGARAEPERLRLKWTNVFLMQHSEGFWELTTQLGELVNVDVDLFANEFLKNKGIRSLGVRAHTDILRL T_rubripes_ENSTRUP00000000233 MFYSYERMTSEDSSAAPLLKHKCPDAAFGMKNPSIIHFKSKSRLFLS---------------FVVPDASTLSGLQDGYWELTPELGTLLNFNADLFANVFLKSKGIDSLGSRARADILRL C_familiaris_ENSCAFP00000010963 -----SSYECFFATENNETPEFLTSCCFQKAAKFDIRGSNFTASFQSQKDE------QSWMNFVPWTELFSLQTEDGFWKLTPELGFILNLNIN-ILNSFLEQKGIRSLGIKGRERLLDL B_taurus_ENSBTAP00000035522 LQYDCSFFECSSETESDKTGELLASRIFKKLAEYDL-RSGFTASTQAQKDEDGLVGKASWRNYVPSTELFRLQTKDGCWKLTQELGFILKLNTN-ILNSFLEQKGIRSLGVRGRERLLDL X_tropicalis_ENSXETP00000043695 ---------------------------------------------------------------------------------------------------------VSTFSLSASQAL--- T_nigroviridis_ENSTNIP00000004824 SRSSSSRSSSSHSSSSRSSSSRSSTQSLAAPAAVPGGFRRASPE------------------GVNWNAIFRRQHVDGYWELTPELGKLLNFDVDLFVNVFLKSKGIDSLGARARADILRL E_caballus_ENSECAP00000007671 ESWPTSSHESSFETESDETSGVLASRFLKKMAKSKINRSDFPAVFLAQENKAKIFSRRSQRSFVPWNELFSLQTEDGFWKLTPELGFILNLNTN-ILNSFLEQKGIRSLGTKGRERLLDL A_carolinensis_ENSACAP00000001773 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000027638 CTAEQEHGKAGNETSFKKSETEMQKALFLFVFPLLLFKLQPSCFITTEKERSQ---QKLEFTPVMWEEIFDLQNQDGSWNLSPQLGKILKFDVDYLINHFLIRNGIQSLGIKGKEKLLKL M_domestica_ENSMODP00000009821 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000012495 ------------------------------------------------------------------------------------------------------------------------ 3610 3620 3630 3640 3650 3660 3670 3680 3690 3700 =========+=========+=========+=========+=========+=========+=========+=========+=========+========== M_musculus_ENSMUSP00000048877 ---------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000011840 ---------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000008035 ---------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000012338 ---------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000250416 ---------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000010339 ---------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000006331 ---------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000004152 ---------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000021361 ---------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000001988 ---------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000008892 ---------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000008175 ---------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000003642 ---------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000003778 ---------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000023516 ---------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000006847 ---------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000027488 ---------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000018492 ---------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000011691 ---------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000014960 ---------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000019481 ---------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000017176 ---------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000008364 ---------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000006218 ---------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000037062 ---------------------------------------------------------------------------------------------------- D_melanogaster_FBpp0112609 ---------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000355759 ---------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000027777 ---------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000000162 ---------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000023715 ---------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000004232 ---------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000001113 ---------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000017400 ---------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000028737 ---------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000002367 ---------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000007535 ---------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000003457 ---------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000048934 ---------------------------------------------------------------------------------------------------- A_aegypti_AAEL011815-PA ---------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000004425 ---------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000038037 ---------------------------------------------------------------------------------------------------- A_gambiae_AGAP003230-PA ---------------------------------------------------------------------------------------------------- C_elegans_Y71F9AL.18.1 ---------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000011424 ---------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000005989 ---------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000000153 ---------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000026625 ---------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000014791 ---------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000001175 ---------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000000924 ---------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000015470 ---------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000381740 ---------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000025859 ---------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000043156 ---------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000016262 ---------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000012158 ---------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000014771 ---------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000017224 ---------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000015305 ---------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000007181 ---------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000108098 ---------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000029228 ---------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000006583 ---------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000006181 ---------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000017650 ---------------------------------------------------------------------------------------------------- C_elegans_E02H1.4 ---------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000000045 ---------------------------------------------------------------------------------------------------- C_elegans_ZK1005.1a ---------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000371419 IATMLVLQFIRTRLEKEGIVFKSLMKMDDASISRN-IPWAFEAIKQASEWVRRTEGQYPSICPRLELGNDWDSATKQLLGLQPISTVSPLHRVLHYSQ-G P_troglodytes_ENSPTRP00000009733 IATMLVLQFIRTRLEKEGIVFKSLMKMDDPSISRN-IPWAFEAIKQASEWVRRTEGQYPSICPRLELGKDWDSATKQLLGLQPISTVSPLHRVLHYSQ-G M_musculus_ENSMUSP00000066130 LAA------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000011271 LATLLVLQLMRVEKLEEGKLLRTLFSLDESPPPRSARPARWEEVKRAVHWVCWADRRYPCVYSRLEFGLSWETSTRQLLGFEGLPPFSALRGLKLQLL-A T_rubripes_ENSTRUP00000000233 VATLLVLQMMRVEKLEEGTLLRTLFSLVESSRHRS---ARWKQVKRAVDWVCWADRQYPCICSRLEFGRSWESSTRQLLGFDVTHHSSPLNKLELRLSPV C_familiaris_ENSCAFP00000010963 IATFLVLQFLRTTLEHKGIVFKSLMKLDDASISRT-IPWAFEEIKKASEWVRRTEGQYPSICQRLELGQDWDSATKQLLG-------------------- B_taurus_ENSBTAP00000035522 IATFLVLQFLRTKLEQEGIIVKSLMRLDDASIPRN-IPWDCEKIKKASEWLRRTEGQYPSICQRLELGKDWDSATKQLLGILPRDAASPPHRLLKHSQ-G X_tropicalis_ENSXETP00000043695 ---------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000004824 LATLLVLQLMRVAKLEEGRLLRTLFSLVDPSQQRS---RGGEQVKRAVDWVRWADRQYPCICSRLEFGLSWESSTRQLLGFEDAHRSSPLTQIVLFYFEG E_caballus_ENSECAP00000007671 IATFLVLQFLRTKLDQEGIVFKSLMKLDDASISRN-IPWASEKIKKASEWLRRTEGQYPSICQRLELGKDWDSATKQLLGIQPMNTTSPLHGVLHYSKD- A_carolinensis_ENSACAP00000001773 ---------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000027638 IATLLVLQFIRCANELQGIVFKSLMKLDNLTTSSG-VHWAFESIKKATEWVKRVEGQFPSICYRLELGKDWDSATKMILGIKCN---------------- M_domestica_ENSMODP00000009821 ---------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000012495 ----------------------------------------------------------------------------------------------------