10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000077757 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000000576 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000000549 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000021385 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000015828 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000050271 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000363591 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000011943 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000001449 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000006150 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002204 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000017616 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000016202 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000018457 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000039057 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000056677 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000001882 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000024313 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000014770 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000008572 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000007865 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000010478 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000365230 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000012163 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000022903 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000017211 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000014135 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000040259 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000007577 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011187 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000017311 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002775 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000010059 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018978 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000086454 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000020984 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000017513 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000089067 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000026248 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000008404 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010457 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250405 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000019355 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000001415 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000025701 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000095258 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006866 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005598 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000022806 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005643 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000008651 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000014671 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000010339 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381185 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000017121 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000003768 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108371 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000000778 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000002093 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017850 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000006458 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000096467 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000031936 ------------------------------------------------------------------------------------------------------------------RKKGNN T_rubripes_ENSTRUP00000032199 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000056470 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000000102 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000053903 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013488 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000010122 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000021005 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000052058 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000024813 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000017228 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000006084 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008963 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL001521-PA MLSAEAPV--------------------------------------------------------SHNHHLLPDRLSAPALARRKFSFPANLHSTVLHGDPPGSINSGSLQPSSTASFARR A_carolinensis_ENSACAP00000004550 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006267 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000017160 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000006891 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005841 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000009257 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018053 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000027499 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000024693 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000033093 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000019323 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000005209 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000044048 MFGLRRNAVIGLNLYCGGASLGAGGGSPAGARLVAEEAKARREGGGEAALLPGARVVARPPPVGAEDPDVTASAERRLHKSPGLLAVPPEEMAASAAAAIVSPEEELDGCEPEAIGKRPA G_aculeatus_ENSGACP00000017662 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000012873 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000015983 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000036334 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000002788 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000017739 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000028328 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000293288 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000314132 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000015296 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000007481 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014939 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000020066 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011552-PA M-SSTAGA--------------------------------------------------------FHQQH-QPQQQSP---------------------------------RSPIVAAAVA D_rerio_ENSDARP00000023687 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018700 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000018321 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000000851 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000011478 ------------------------------------------------------------------------------------------------------------------------ 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000077757 ---MASGQGPGPPK-----VGCDES--PSPS--EQQVAQDTEEVFRSYVFYLHQQEQETQGAAA-------------------------------------------------------- R_norvegicus_ENSRNOP00000000576 ---MASGQGPGPPK-----GDCDEA--LSAS--EQQVAQDTEEVFRSYVFYLHQQEQETQGAAA-------------------------------------------------------- B_taurus_ENSBTAP00000000549 ---MASGQGPGPPG-----QDCDEPDPSSTS--EEQVARDTEEVFRSYVFYRHQQEQEAEGAAA-------------------------------------------------------- E_caballus_ENSECAP00000021385 ---MASGQGPGPPG-----KECGEPAPSSTS--EEQVARDTEEVFRSYVYYRHQQEQEAEGAAA-------------------------------------------------------- G_gorilla_ENSGGOP00000015828 ---MASGQGPGPPR-----QECGEPALPSAS--EEQVAQDTEEVFRSYVFYRHQQEQEAEGAAA-------------------------------------------------------- P_troglodytes_ENSPTRP00000050271 ---MASGQGPGPPR-----QECGEPALPSAS--EEQVAQDTEEVFRSYVFYRHQQEQEAEGAAA-------------------------------------------------------- H_sapiens_ENSP00000363591 ---MASGQGPGPPR-----QECGEPALPSAS--EEQVAQDTEEVFRSYVFYRHQQEQEAEGVAA-------------------------------------------------------- M_mulatta_ENSMMUP00000011943 ---MASGQGPGPPR-----QECGEPALPSASGKEEQVARDTEEVFRSYVFYRHQQEQEAEGAAA-------------------------------------------------------- C_familiaris_ENSCAFP00000001449 ---MASGQGPGPPR-----RECGEAAPSSTS--EEQVARDTEEVFRSYVFYRHRQEQEAEGAAV-------------------------------------------------------- P_pygmaeus_ENSPPYP00000006150 ---MASGQGPGPPR-----QECGEPALPSAS--EEQVARDTEEVFRSNVFHRHQQEQEAEGAAA-------------------------------------------------------- O_cuniculus_ENSOCUP00000002204 ----------------------------------QQVARDTEEVFRSYVFHRHRQEQEAEGAAA-------------------------------------------------------- M_domestica_ENSMODP00000017616 ------------------------------T--EEQVARETEEVFRSYVYYRHQQEQETEGEAV-------------------------------------------------------- A_carolinensis_ENSACAP00000016202 ------------------------------A--EDQVAQETEEVFQSYAFYRYQQEREQTEGDV-------------------------------------------------------- P_pygmaeus_ENSPPYP00000018457 ---MASGQGPGPPR-----QECGEPALPSAS--EEQVARDTEEVFRSYVFYRHQQEQEAEGAAA-------------------------------------------------------- G_gallus_ENSGALP00000039057 ---MEGNEGDPPGAHRRRDSHGRRPSREINA--EDQVAQETEEVFRSYTFYRYQQEREEGGAEV-------------------------------------------------------- X_tropicalis_ENSXETP00000056677 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000001882 ----------------------------A----EGRVAEEAEEVFRSFAFYRYQQEREERGAEL-------------------------------------------------------- M_domestica_ENSMODP00000024313 ------------------------------------MSHSNRELVIDFLSYKLSQKGYNWSQFE--D----ENRT-----EVLEGA----------EIPSTV-----------NGSPSWH E_caballus_ENSECAP00000014770 ------------------------------------MSQSNRELVVDFLSYKLSQKGYNWSQFS--DV--EENRT-----EAPEGTE------SEMETPSAI-----------NGNPSWH B_taurus_ENSBTAP00000008572 ------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQFS--DV--EENRT-----EAPEGTE------SDMETPSAI-----------NGNASWH M_mulatta_ENSMMUP00000007865 ------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQFS--DV--EENRT-----EAPEGTE------SEMETPSAI-----------NGNPSWH C_familiaris_ENSCAFP00000010478 ------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQFS--DV--EENRT-----EAPEGTE------SEMETPSAI-----------NGNPSWH H_sapiens_ENSP00000365230 ------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQFS--DV--EENRT-----EAPEGTE------SEMETPSAI-----------NGNPSWH P_pygmaeus_ENSPPYP00000012163 ------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQFS--DV--EENRT-----EAPEGTE------SEMETPSAI-----------NGNPSWH P_troglodytes_ENSPTRP00000022903 ------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQFS--DV--EENRT-----EAPEGTE------SEMETPSAI-----------NGNPSWH T_nigroviridis_ENSTNIP00000017211 ----------------------------DVV--DDPILEQGAVVLRGYVIERIH-VEQPSLHV--------------------------------------------------------- T_rubripes_ENSTRUP00000014135 ------------------------------------MS-QNRELVIFYIKYKLSQRNYPFNHNGLILE--PPSRT-----DG---------QFVTTQFNGTF-----------NGASPGT R_norvegicus_ENSRNOP00000040259 ------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQFS--DV--EENRT-----EAPEETE------PERETPSAI-----------NGNPSWH T_nigroviridis_ENSTNIP00000007577 ---------------------RSHPGAKSKGASTQRMS-LNRELVIFYIKYKLSQRNYPLSH---IVE--PSSRT-----EG---------QFGTTQSNGTF-----------NGASPGT A_carolinensis_ENSACAP00000011187 ------------------------------------MSSSNRALVVDFLSYKLSQRGHSWHEIE--ME------------SGEEAME------PANETGNTL-----------NGSPSWH A_carolinensis_ENSACAP00000017311 ----------------------------MAH--PGIRGYDNREIVLRYIHYKLSQKGYDWVASGDRGN--LAAAA-----AAAAATPSAPTVS--------------------ASLSPEL O_cuniculus_ENSOCUP00000002775 ------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQFS--DV--EENRT-----EAPEGTG------PEMETPSAI-----------NGNPAWH G_gallus_ENSGALP00000010059 ------------------------------------MSSSNRELVIDFVSYKLSQRGHCWSELE--EE--DENRT-----DTA----------AEAEMDSVL-----------NGSPSWH G_aculeatus_ENSGACP00000018978 -----MADGGREKQDDGDREPRGAEGGEDVV--DDPIMEQGAVVLRGYVVSRIN-AEDPSRHV--------------------------------------------------------- M_musculus_ENSMUSP00000086454 ------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQFS--DV--EENRT-----EAPEETE------AERETPSAI-----------NGNPSWH G_gallus_ENSGALP00000020984 ----------------------------MAH--PGRRGYDNREIVLKYIHYKLSQRGYDW----AAGEDRPPVPP--------APAPAAAPAAVAAAGAS-------------SHHRPEP O_latipes_ENSORLP00000017513 --------------------------------QAHTMSHCNRELVRFYLAYKMSCRDYPVSLLK-PTD--DGGET-----EEDHSDA--RNRRLVSSEDGR------------------- D_rerio_ENSDARP00000089067 ------MADGKNGETTDENELKGATGGEDVV--DDAIIEQSAVLLRGYVIQQAT-IDDPNIHV--------------------------------------------------------- B_taurus_ENSBTAP00000026248 -----------------------------MA--TPASAPDTRALVADFVGYKLRQKGYV------------------------------------------------------------- E_caballus_ENSECAP00000008404 -----------------------------MA--TPASAPDTRALVADFVGYKLRQKGYV------------------------------------------------------------- P_troglodytes_ENSPTRP00000010457 -----------------------------MA--TPASAPDTRALVADFVGYKLRQKGYV------------------------------------------------------------- H_sapiens_ENSP00000250405 -----------------------------MA--TPASAPDTRALVADFVGYKLRQKGYV------------------------------------------------------------- M_mulatta_ENSMMUP00000019355 -----------------------------MA--TPASAPDTRALVADFVGYKLRQKGYV------------------------------------------------------------- G_gorilla_ENSGGOP00000001415 -----------------------------MA--TPASAPDTRALVADFVGYKLRQKGYV------------------------------------------------------------- B_taurus_ENSBTAP00000025701 ----------------------------------------------------------------------------------------------------------------PSRTSPPP D_rerio_ENSDARP00000095258 ------------------------------------MSYYNRELVVFFIKYKLSQRNYPCNHIG-LTE--DTNRT-----DGAEENG-EGAAGATTLVNGTMNRT--------NASSTGT T_guttata_ENSTGUP00000006866 ------------------------------------MYSSNRELVIDFVSYKLSQKGYSWSQLE--EE--DENRT-----DFAGE---------EDEMDGVL-----------NGSPSWH M_domestica_ENSMODP00000005598 -----------------------------MA--TPASAPDTRALVADFVGYKLRQKGYA------------------------------------------------------------- M_musculus_ENSMUSP00000022806 -----------------------------MA--TPASTPDTRALVADFVGYKLRQKGYV------------------------------------------------------------- G_aculeatus_ENSGACP00000005643 ------------------------------------MS-QNRELVVFYINYKLSQRNLPLNHIG-LSE--PPNRT-----GGGVEAGAAGGQRGATHSNGTF-----------NGTSPGT M_mulatta_ENSMMUP00000008651 ----------------------------MAH--AGRTGYDNREIVMKYIHYKLSQRGYEW----DAGD--VGAAT-----PGAAPAPGIFSSQPGHTPHPAASRD------PVARTSPLP O_anatinus_ENSOANP00000014671 -------------------------AAPRMATPAPASVSDTRALVADFVGYKLRQKGF-------------------------------------------------------------- P_pygmaeus_ENSPPYP00000010339 ----------------------------MAH--AGTTGYDNREIVDEXIHYKLSQRGYEW----DAGD--VGAAP-----PGAATAPGIFSSQPGHTPHPAASRD------P-ARTSPLP H_sapiens_ENSP00000381185 ----------------------------MAH--AGRTGYDNREIVMKYIHYKLSQRGYEW----DAGD--VGAAP-----PGAAPAPGIFSSQPGHTPHPAASRD------PVARTSPLQ P_troglodytes_ENSPTRP00000017121 ----------------------------MAH--AGRTGYDNREIVMKYIHYKLSQRGYEW----DAGD--VGAAP-----PGAAPAPGIFSSQPGHTPHPAASRD------PVARTSPLQ R_norvegicus_ENSRNOP00000003768 ----------------------------MAQ--AGRTGYDNREIVMKYIHYKLSQRGYEW----DTGD--EDSAP-----LRAAPTPGIFSFQPESNRTPAVHRD------TAARTSPLR M_musculus_ENSMUSP00000108371 ----------------------------MAQ--AGRTGYDNREIVMKYIHYKLSQRGYEW----DAGD--ADAAP-----LGAAPTPGIFSFQPESNPMPAVHRD------MAARTSPLR G_gorilla_ENSGGOP00000000778 ----------------------------MAH--AGRTGYDNREIVMKYIHYKLSQRGYEW----DAGD--VGAVP-----PGAAPAPGIFSSQPGHTPHPAASRD------RVARTSPLQ T_guttata_ENSTGUP00000002093 ----------------------------MAH--PGRRGYDNREIVLKYIHYKLSQRGYDW----AAGEDRASLPP----DHSASAAAAIAAAAIAAAGTSDHTGL--------VSPHPEP E_caballus_ENSECAP00000017850 ----------------------------MAH--AGRTGYDNREIVMKYIHYKLSQRGYEW----DAGD--AGAAP-----LGATPVPGIFSSQPGRTPAP-------------ARTSPLL M_domestica_ENSMODP00000006458 ----------------------------MAH--PGRRGYDNREIVMKYIHYKLSQRGYEW----DAGDLRAPASPSLPPVVASAPAVGIFSTQPRNTPLPAEPQDSATSTTAAARNSPLP D_rerio_ENSDARP00000096467 ------------------------------M--ANEISYDNRNIVEKYLKHKLSKRGYVWKCQSSAE---EDDTF-----NKAVEESSPNSDRRLQAPSAGG------------------ X_tropicalis_ENSXETP00000031936 GVKDRDWEEQHATGNIIFRGSPDKYLTEQGW--MAQSELGSRALVEDFVRYKLCQRSL-------------------------------------------------------------- T_rubripes_ENSTRUP00000032199 ------------------------------------MSYNNRELVEHFLRYKLSQRNYPTSLLR-PED--TDGRT-----EGEKRSP-GASNGLLVRSRNR------------------- R_norvegicus_ENSRNOP00000056470 ---------------------------------IPVSTPDTWALVADFVGYKL------------------------------------------------------------------- C_familiaris_ENSCAFP00000000102 ----------------------------MAH--AGRTGYDNREIVMKYIHYKLSQRGYEW----DAGE--AGAAP-----PGAAPAPGI------------------------------- X_tropicalis_ENSXETP00000053903 ------------------------------------MEGSSRDLVEKFVCKKLSQKGACGEFSS-NSQ--PKGVS-----NGSSEGP--------------------------------- G_aculeatus_ENSGACP00000013488 ------------------------------------MANINRELVEFFLSYKLSQKNHPTSLLR-PED--AGGRT-----EGDKANS-ASVPG--------------------RGSSAGQ T_nigroviridis_ENSTNIP00000010122 ------------------------------------MSYDNRELVEYFLGYKLAQRNYPSSLLR-PQE--PDGWT-----EGDKKSP-AAVNGLLIRNRSR------------------- O_latipes_ENSORLP00000021005 -----------------------------------MANVSNRSIVEKYICHKLSKRGYVCGLN-GGQR--ENAAN-----NGSVGDH--------------------------------- X_tropicalis_ENSXETP00000052058 ----------------------------MAH--PRRGGYDHRDIVVKYIHYKLSQKGYEW----EEGRQQVSAEH-----PQASAAISNYSDD---GEMPAASAD--------SRGPPQS C_intestinalis_ENSCINP00000024813 --------------------------------------EQARFLLNMFIQDRAADMS--------------------------------------------------------------- A_carolinensis_ENSACAP00000017228 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000006084 --------MDMLRRSSVFAA---EVFDRSPT--DKELVSQAKALCRDYIHSRLNRAGMGWSKP--------------------------------------------------------- O_anatinus_ENSOANP00000008963 --------MEVLRRSSVFAAEVMEVFDRSPT--DKELVSQAKALCREYIHSRLIRASLVWSKP--------------------------------------------------------- A_aegypti_AAEL001521-PA RLSNVSDVVTRKLSSTIGWKQPVLP--------SQDIITQGKCLCGQYIRCRLKKSGVFNRKLGLQRIR--------------------------------------------------- A_carolinensis_ENSACAP00000004550 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006267 --------MEVLRRSSVFAAEVMEVFDRSPT--DKELVSQAKALCRDYINSRLIQAGVSWSKP--------------------------------------------------------- M_domestica_ENSMODP00000017160 ---------------MDGSGEQPRGGAGATS--SEQIMRTGAVLLQGFIQDRAGRVAGGAPEL--------------------------------------------------------- T_rubripes_ENSTRUP00000006891 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005841 --------MEMLRRSSMFAA---EVFDRSPT--DKELVSQAKALCRDYIHSRLNRAGIGWSKA--------------------------------------------------------- G_gallus_ENSGALP00000009257 --------MEVLRRSSVFAAEVMEVFDRSPT--DKELVSQAKALCRDYINSRLIRAGVSWSKP--------------------------------------------------------- G_aculeatus_ENSGACP00000018053 --------MEVLRRPSVMAAEVLDVFDRSLT--EKELVSQSKALCRDYILSRLHQNGQGWSKT--------------------------------------------------------- M_musculus_ENSMUSP00000027499 --------MEVLRRSSVFAAEIMDAFDRSPT--DKELVAQAKALGREYVHARLLRAGLSWSAP--------------------------------------------------------- R_norvegicus_ENSRNOP00000024693 --------MEVLRRSSVFAAEIMDAFDRSPT--DKELVAQAKALGREYVHARLLRAGLSWSAP--------------------------------------------------------- M_musculus_ENSMUSP00000033093 ---------------MDGSGEQLGSG-GPTS--SEQIMKTGAFLLQGFIQDRAGRMAGETPEL--------------------------------------------------------- P_troglodytes_ENSPTRP00000019323 ---------------MDGSGEQPRGG-GPTS--SEQIMKTGALLLQGFIQDRAGRMRGEAPEL--------------------------------------------------------- M_mulatta_ENSMMUP00000005209 ---------------MDGSGEQPRGG-GPTS--SEQIMKTGALLLQGFIQDRAGRMGGETPEL--------------------------------------------------------- M_musculus_ENSMUSP00000044048 VLPLLERVSEAAKSSGADGSLPSTPPPPEEE--EDDLYRQSLEIISRYLREQATGSKD-------------------------------------------------------------- G_aculeatus_ENSGACP00000017662 -----------------------------------MSNECNRHIVEKYICHKLSKRGYAFGFD-DVGE--EDAAS-----NGSMVVPPPTAVRRCRE----------------A--GP-- T_rubripes_ENSTRUP00000012873 --------------------------------QVGMERECNRDIVENYICHKLSKRGFAWSFE-DVQD--ENAAN-----NGSVVAPAPTLVRRCHE----------------AGTGPDR T_guttata_ENSTGUP00000015983 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000036334 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000002788 -----------------------------------MAREYNRDIVEKYIFHKLSKRGFVWRFE-EVQD--QNAAN-----NGSVVAPAPTLVRRCHE----------------AGTGP-- B_taurus_ENSBTAP00000017739 ---------------MDGSGEQPRGG-GPTS--SEQIMKTGALLLQGFIQDRAGRMGGETPEL--------------------------------------------------------- R_norvegicus_ENSRNOP00000028328 ---------------MDGSGDHLGGG-GPTS--SEQIMKTGAFLLQGFIQDRAERMAGETPEL--------------------------------------------------------- H_sapiens_ENSP00000293288 ---------------MDGSGEQPRGG-GPTS--SEQIMKTGALLLQGFIQDRAGRMGGEAPEL--------------------------------------------------------- H_sapiens_ENSP00000314132 --------MEVLRRSSVFAAEIMDAFDRSPT--DKELVAQAKALGREYVHARLLRAGLSWSAP--------------------------------------------------------- G_gorilla_ENSGGOP00000015296 --------MEVLRRSSVFAAEIMDAFDRSPT--DKELVAQAKALGREYVHARLLRAGLSWSAP--------------------------------------------------------- M_mulatta_ENSMMUP00000007481 --------MEVLRRSSVFAAEIMDAFDRSPT--DKELVAQAKALGREYVHARLLRAGLSWSAP--------------------------------------------------------- P_pygmaeus_ENSPPYP00000014939 --------MEVLRRSSVFAAEIMDAFDRSPT--DKELVAQAKALGREYVHARLLRAGLSWSAP--------------------------------------------------------- M_domestica_ENSMODP00000020066 --------MEVLRRSSVFAAEVMEVFDRSPT--DKELVSQAKALGREYIHSRLIRAGLVWSKP--------------------------------------------------------- A_gambiae_AGAP011552-PA AAAAIGAVSGGSAGGVVGWTNKRSPIHHLTT--SQDVINQGKCLCGEYIRARLKRSGLLNRKI-LQRLRNS------------------------------------------------- D_rerio_ENSDARP00000023687 ---------------M---AAPSGGGDTGSG--NDQILDLGAALLNNFVYERVRRHGDRDAEV--------------------------------------------------------- G_aculeatus_ENSGACP00000018700 ---------------M---ASHPGGGDQGNN--KDQILELGTVLLKDFIFERVKRHGDSTETV--------------------------------------------------------- T_nigroviridis_ENSTNIP00000018321 --------MEVLRRSSVFAAEVLDVFDRSLT--EKELVSHSKALCRDYILSRLTQSGLGWSKS--------------------------------------------------------- A_carolinensis_ENSACAP00000000851 --------MDVLRRSSVFAAEVMEVFDRTPT--DKELVSQAKVLCRDFIHSRLIRAGIGWNKP--------------------------------------------------------- B_taurus_ENSBTAP00000011478 --------MEVLRRSSVFAAEIMDAFDRSPT--DKELVAQAKALGREFVHARLLRAGLSWSAP--------------------------------------------------------- 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000077757 ---PANPEMDNLPLEPNSIL---------GQVGRQLALIGDDINRRYDTEFQNLLEQLQP-------TAGNAYELFTKIA--S------S----LFKSG-ISWGRVVALLGFGYRLALY- R_norvegicus_ENSRNOP00000000576 ---PANPEMDNLSLEPNSVL---------GQVGRQLALIGDDINRRYDTEFQNLLEQLQP-------TAGNAYELFTKIA--S------S----LFKSG-ISWGRVVALLGFGYRLALY- B_taurus_ENSBTAP00000000549 ---PTDPEMVTLHPEPSSTM---------GQVGRQLAVIGDDINRRYDAEFQAMLQHLQP-------TADNAYEYFTKIA--S------S----LFESG-INWGRVVALLGFGYRLALH- E_caballus_ENSECAP00000021385 ---PADPEMDTLPLEPNSTM---------GQVGRQLAIIGDDINRRYDSEFQTMLKHLQP-------TAENAYELFTKIA--S------S----LFESG-INWGRVVALLGFGYRLALH- G_gorilla_ENSGGOP00000015828 ---PADPEMVTLPLQPSSTM---------GQVGRQLAIIGDDINRRYDSEFQTMLQHLQP-------TAENAYEYFTKIA--T------S----LFESG-INWGRVVALLGFGYRLALH- P_troglodytes_ENSPTRP00000050271 ---PADPEMVTLPLQPSSTM---------GQVGRQLAIIGDDINRRYDSEFQTMLQHLQP-------TAENAYEYFTKIA--T------S----LFESG-INWGRVVALLGFGYRLALH- H_sapiens_ENSP00000363591 ---PADPEMVTLPLQPSSTM---------GQVGRQLAIIGDDINRRYDSEFQTMLQHLQP-------TAENAYEYFTKIA--T------S----LFESG-INWGRVVALLGFGYRLALH- M_mulatta_ENSMMUP00000011943 ---PADPEMDTLPLQPSSTM---------GQVGRQLAIIGDDINRRYDSEFQTMLQHLQP-------TAENAYEYFTKIA--S------SS--VLFESG-INWGRVVALLGFGYRLALH- C_familiaris_ENSCAFP00000001449 ---PADPEMVTLPLEPSSTM---------GQVGRQLAIIGDDINQRYDSEFQAMLQHLQP-------TAENAYEYFTKIA--S------RCHLFLFESG-INWGRVVALLGFGYRLALH- P_pygmaeus_ENSPPYP00000006150 ---PADPEMVTLPLQPSSTM---------GQVGRQLAIIGDDINRRYDSEFQTMLQHLQP-------TAENTCEYFTKIA--S------S----LFESG-INWGRVVALLGFGYRLALH- O_cuniculus_ENSOCUP00000002204 ---PADPEMISLHLEPNSTM---------GQVGRQLAIIGDDINQRYDSDFQNMLEKLQP-------TAENAYELFTKIALSS------D----LFESG-INWGRVVALLAFGYRLALY- M_domestica_ENSMODP00000017616 ---PADPEMDTLPQELSSTT---------EQVGRQLAVIGDDISRRYDSEFKAMLQHLQP-------TPDTAYEYFTKIA--SRISAPHS----LFESG-INWGRVVALLGFGYRLALH- A_carolinensis_ENSACAP00000016202 ---PHDPEIAAIPHEPNSTN---------CQVGRRLATIGDDINARYDKEFSEMLKSLQP-------TKDNAYEYFIRIA--S------S----LFESG-INWGRVIALLGFGYRMAIH- P_pygmaeus_ENSPPYP00000018457 ---PADPEMVTLPLQPS-------------------------------------------------------YEYFTKIA--S------S----LFESG-INWGRVVALLGFGYRLALH- G_gallus_ENSGALP00000039057 ---PMDPEIMEIQQELGSTG---------SQVGRRLAIIGDDINKRYDAEFRHMLKSLQP-------TKENAYEYFTTIA--S------S----LFDSG-INWGRVIALLGFGYCMAIH- X_tropicalis_ENSXETP00000056677 -----------------XNL---------ISVGQQLAKIGDDINERYQEQFDDILKHLNP-------SLDNAYSYFKKIA--S------S----LFENG-INWGRILSLLGFGYRMAVY- T_guttata_ENSTGUP00000001882 ---PRDPEIEQLQQDPCSTE---------SQVGQRLAIIGDDIYKRYDAEF-SMLESLQP-------TRDN------------------------------------------------- M_domestica_ENSMODP00000024313 PA-DSRA--VSGATGHSSSL-DAHETIPVAAVKQALREAGDEFELRYRRAFSDLTSQLHI-------TPGTAYQSFEQVV--N------E----LFRDG-VNWGRIVAFFSFGGALCVE- E_caballus_ENSECAP00000014770 LA-DSPT--GNGATGHSSSL-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHI-------TPGTAYQSFEQVV--N------E----LFRDG-VNWGRIVAFFSFGGALCVE- B_taurus_ENSBTAP00000008572 LA-DSPA--VNGATGHSRSS-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHI-------TPGTAYQSFEQVV--N------E----LFRDG-VNWGRIVAFFSFGGALCVE- M_mulatta_ENSMMUP00000007865 LV-DSPA--VNGATGHSSSL-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHI-------TPGTAYQSFEQVV--N------E----LFRDG-VNWGRIVAFFSFGGALCVE- C_familiaris_ENSCAFP00000010478 LA-DSPA--VNGATGHSSSL-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHI-------TPGTAYQSFEQVV--N------E----LFRDG-VNWGRIVAFFSFGGALCVE- H_sapiens_ENSP00000365230 LA-DSPA--VNGATGHSSSL-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHI-------TPGTAYQSFEQVV--N------E----LFRDG-VNWGRIVAFFSFGGALCVE- P_pygmaeus_ENSPPYP00000012163 LA-DSPA--VNGATGHSSSL-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHI-------TPGTAYQSFEQVV--N------E----LFRDG-VNWGRIVAFFSFGGALCVE- P_troglodytes_ENSPTRP00000022903 LA-DSPA--VNGATGHSSSL-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHI-------TPGTAYQSFEQVV--N------E----LFRDG-VNWGRIVAFFSFGGALCVE- T_nigroviridis_ENSTNIP00000017211 ---SSEDLGGRSEEQRDPQT---------KEVVEQLLKIADDLNR--NAEFQHLVSQV---------QGNCAQDVFMQVA--R------S----IFADG-INWGRVVALFHLAYRLILK- T_rubripes_ENSTRUP00000014135 PP----------ATSLATSL---------DTVKEALRDTGNEFELRYTCAFSDLHNQLHI-------TPATAYQSFENVM--D------E----VFRDG-VNWGRIVGLFAFGGALCVE- R_norvegicus_ENSRNOP00000040259 LA-DSPA--VNGATGHSSSL-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHI-------TPGTAYQSFEQVV--N------E----LFRDG-VNWGRIVAFFSFGGALCVE- T_nigroviridis_ENSTNIP00000007577 PP------APSQHQQSLTSL---------DAVKEALRDTGNEFELRYTCAFSDLHNQLHI-------TPATAYQSFENVM--D------E----VFRDG-VNWGRIVGLFAFGGALCVE- A_carolinensis_ENSACAP00000011187 PS-PSHV--INGASEHPELLEEEEEENPRVDVSQTLREAGDEFELRYRRAFSDLTSQLHI-------TLGTAYQSFEQVV--N------E----LFHDG-VNWGRIVAFFSFGGALCVE- A_carolinensis_ENSACAP00000017311 LN-SDPVSTNAPREEPDPVP---------QVVHTTLRQAGDEFSRRYRRDFAQMSGQLHL-------TPSTARSRFVAVV--E------E----LFQDG-VNWGRIVAFFEFGGMLCVE- O_cuniculus_ENSOCUP00000002775 PA-DSPA--VNGATGHSSSL-DAREVIPMTAVKQALREAGDEFELRYRRAFSDLTSQLHI-------TPGTAYQSFEQVV--N------E----LFRDG-VNWGRIVAFFSFGGALCVE- G_gallus_ENSGALP00000010059 PP-AGHV--VNGATVHRSSL-EVHEIVRASDVRQALRDAGDEFELRYRRAFSDLTSQLHI-------TPGTAYQSFEQVV--N------E----LFHDG-VNWGRIVAFFSFGGALCVE- G_aculeatus_ENSGACP00000018978 ---SPEQLGGRPNEHQDPQI---------KEVVKQLMKIADEMNR--NAELQRLISQV---------PGNCAQDIFMKVA--K------S----IFDDG-INWGRVVALFHLAYRLIYR- M_musculus_ENSMUSP00000086454 LA-DSPA--VNGATGHSSSL-DAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHI-------TPGTAYQSFEQVV--N------E----LFRDG-VNWGRIVAFFSFGGALCVE- G_gallus_ENSGALP00000020984 PG-SAAASEVPPAEGLRPAP---------PGVHLALRQAGDEFSRRYQRDFAQMSGQLHL-------TPFTAHGRFVAVV--E------E----LFRDG-VNWGRIVAFFEFGGVMCVE- O_latipes_ENSORLP00000017513 ---------LRRSCPCCASM---------DAIKSTLKDSADEFERRFHQGFSDLSVQLHI-------TPDTAYQNFKRVL--D------E----LFKDG-INWGRVVGLFVFGGALCVE- D_rerio_ENSDARP00000089067 ---SHETLGGRPQDEEDPQI---------KEVVDQLLKIADDLNK--NAELQHLISTV---------QSNCAQDVFMTVA--R------S----IFDDG-INWGRVVALFHLAYRLIFQ- B_taurus_ENSBTAP00000026248 ---------CGAGPGEGPAA---------DPLHQAMRAAGDEFETRFRRTFSDLAAQLHV-------TPGSAQQRFTQVS--D------E----LFQGG-PNWGRLVAFFVFGAALCAE- E_caballus_ENSECAP00000008404 ---------CGAGPGEGPAA---------DPLHQAMRAAGDEFETRFRRTFSDLAAQLHV-------TPGSAQQRFTQVS--D------E----LFQGG-PNWGRLVAFFVFGAALCAE- P_troglodytes_ENSPTRP00000010457 ---------CGAGPGEGPAA---------DPLHQAMRAAGDEFETRFRRTFSDLAAQLHV-------TPGSAQQRFTQVS--D------E----LFQGG-PNWGRLVAFFVFGAALCAE- H_sapiens_ENSP00000250405 ---------CGAGPGEGPAA---------DPLHQAMRAAGDEFETRFRRTFSDLAAQLHV-------TPGSAQQRFTQVS--D------E----LFQGG-PNWGRLVAFFVFGAALCAE- M_mulatta_ENSMMUP00000019355 ---------CGAGPGEGPAA---------DPLHQAMRAAGDEFETRFRRTFSDLAAQLHV-------TPGSAQQRFTQVS--D------E----LFQGG-PNWGRLVAFFVFGAALCAE- G_gorilla_ENSGGOP00000001415 ---------CGAGPGEGPAA---------DPLHQAMRAAGDEFETRFRRTFSDLAAQLHV-------TPGSAQQRFTQVS--D------E----LFQGG-PNWGRLVAFFVFGAALCAE- B_taurus_ENSBTAP00000025701 PP------AAAAGPAPSPVP---------PVVHLTLRQAGDDFSRRYRRDFAEMSSQLHL-------TPFTARGRFATVV--E------E----LFRDG-VNWGRIVAFFEFGGVMCVE- D_rerio_ENSDARP00000095258 PP-QSPASSPQRQTNGSGGL---------DAVKEALRDSANEFELRYSRAFNDLSSQLHI-------TPATAYQSFESVM--D------E----VFRDG-VNWGRIVGLFAFGGALCVE- T_guttata_ENSTGUP00000006866 AA-TSHI--VNGATVHQNSL-EVHEIRRAADVRQALREAGDEFELRYRRAFSDLTSQLHI-------TPSTAYQSFEQVV--N------E----LFRDG-VNWGRIVAFFSFGGALCVE- M_domestica_ENSMODP00000005598 ---------CGTGPGEGPTT---------EPLHRAMRAAGDEFESRFRRTFSDLAAQLHV-------TPGSAQQRFTQVS--D------E----LFQGG-PNWGRLVAFFVFGAALCAE- M_musculus_ENSMUSP00000022806 ---------CGAGPGEGPAA---------DPLHQAMRAAGDEFETRFRRTFSDLAAQLHV-------TPGSAQQRFTQVS--D------E----LFQGG-PNWGRLVAFFVFGAALCAE- G_aculeatus_ENSGACP00000005643 PP-ASPL--LQQRSPSTASL---------DAVKEALRDSANEFELRYARAFSDLHNQLHI-------TPATAYQSFEDVM--D------E----VFRDG-VNWGRIVGLFAFGGALCVE- M_mulatta_ENSMMUP00000008651 TP-AAPAAAAAAGPALSPVP---------PVVHLTLRQAGDDFSRRYRRDFAEMSSQLHL-------TPFTARGRFATVV--E------E----LFRDG-VNWGRIVAFFEFGGVMCVE- O_anatinus_ENSOANP00000014671 -------------------A---------QPLHRAMRAAGDEFESRFRRAFSDLASQLHV-------TPGSAQQRFTQVS--D------E----LFQGG-PNWGRLVAFFVFGAALCAE- P_pygmaeus_ENSPPYP00000010339 TP-AAP--GAAVGPALSPVP---------PVVHLTLRQAGDDFSRRYRRDFAEMSSQLHL-------TPFTARGRFATVV--E------E----LFRDG-VNWGRIVAFFEFGGVMCVE- H_sapiens_ENSP00000381185 TP-AAP--GAAAGPALSPVP---------PVVHLTLRQAGDDFSRRYRRDFAEMSSQLHL-------TPFTARGRFATVV--E------E----LFRDG-VNWGRIVAFFEFGGVMCVE- P_troglodytes_ENSPTRP00000017121 TP-AAP--GAAAGPALSPVP---------PVVHLTLRQAGDDFSRRYRRDFAEMSSQLHL-------TPFTARGRFATVV--E------E----LFRDG-VNWGRIVAFFEFGGVMCVE- R_norvegicus_ENSRNOP00000003768 PL------VATAGPALSPVP---------PVVHLTLRRAGDDFSRRYRRDFAEMSSQLHL-------TPFTARGRFATVV--E------E----LFRDG-VNWGRIVAFFEFGGVMCVE- M_musculus_ENSMUSP00000108371 PL------VATAGPALSPVP---------PVVHLTLRRAGDDFSRRYRRDFAEMSSQLHL-------TPFTARGRFATVV--E------E----LFRDG-VNWGRIVAFFEFGGVMCVE- G_gorilla_ENSGGOP00000000778 TP-AAP--GAAAGPALSPVP---------PVVHLTLRQAGDDFSRRYRRDFAEMSSQLHL-------TPFTARGRFATVV--E------E----LFRDG-VNWGRIVAFFEFGGVMCVE- T_guttata_ENSTGUP00000002093 PG-SATASHTPPAEGLRPAP---------QAVHLVLRQAGDEFSRRYQRDFSQMSGQLHL-------TPFTARSRFVAVV--E------E----LFRDG-VNWGRIVAFFEFGGVMCVE- E_caballus_ENSECAP00000017850 PP-AAP--AGAAGPALSPVP---------PVVHLTLRQAGDDFSRRYRRDFAEMSSQLHL-------TPFTARGRFATVV--E------E----LFRDG-VNWGRIVAFFEFGGVMCVE- M_domestica_ENSMODP00000006458 LPPPAVAAAAAAGPTVSPVP---------PVVHLTLRQAGDDFSRRYRRDFDEMSGQLHL-------TPVTARGRFATVV--E------E----LFRDG-VNWGRIVAFFEFGGVMCVE- D_rerio_ENSDARP00000096467 ---GNNSECLIARVTRSDPH---------LRLYRVLRDAGDEIERIYQREFEEMSQQMVF-------NPNSAQRSFLTVA--E------E----LFRDG-VNWGRIIAFFEFGGTMCVE- X_tropicalis_ENSXETP00000031936 -----------VPEPAGAAS---------CSLHSAMRAAGDEFEERFRQAFSEISTQIHV-------TPGTAYARFAEVA--G------S----LFQGG-VNWGRIVAFFVFGAALCAE- T_rubripes_ENSTRUP00000032199 ---------GGASPSAGAGI---------EAVNAALRDSAEEFEKLFAQAFSDLSSQLDI-------TPDTAYQSFKNVM--D------E----VFKDG-VNWGRVVGLFAFGGVLCVE- R_norvegicus_ENSRNOP00000056470 ---------SGAGPGKGPAA---------DLLHQAMHAAGDEFETRFRYTFSDLATQQHV-------TPGSAQQRFTQVS--D------E----LFQGG-PNWGRLVAFSVFGAALCAE- C_familiaris_ENSCAFP00000000102 ------------SASXSPVP---------PVVHLTLRQAGDDFSRRYRR-FAEMSSQLHL-------TPFTARGRFATVV--E------E----LFRDG-VNWGRIVAFFEFGGVMCVE- X_tropicalis_ENSXETP00000053903 ------------GATQGIVG---------EEVLQALLDASEEFELRYQRAFSDLTAQLHL-------TQDTAQQSFQQVV--G------E----LFRDG-TNWGRIVAFFSFGRALCVE- G_aculeatus_ENSGACP00000013488 PG------MSSPPPPPSGDT---------EAVKAALQDSANEFELLFTQAFSDLSLQLDV-------TPDTAYHSFKSVM--D------E----VFKDG-VNWGRVVGLFAFGGVLCVE- T_nigroviridis_ENSTNIP00000010122 ---------SGASASTGAGV---------EAVHAALRDSAEEFEKLFAQAFSDLSSQLVI-------TPDTAYQSFKNVM--D------E----VFKDG-VNWGRIVGLFAFGGVLCVE- O_latipes_ENSORLP00000021005 ------------SPTPADPL---------ADIHRVLREAGDELERLYQRDFTEMSRQLYL-------TSTTAKTRFAEVI--D------E----LFRDG-VNWGRIIAFFEFGGTVCVEC X_tropicalis_ENSXETP00000052058 SLASAAASSDEETPTMQPVP---------PAVLQTLSRAGDEFSRLYQQDFRQISGLLHL-------TPSTVRVRFATVV--E------E----LFHDG-VNWGRIVAFFEFGGVMCVE- C_intestinalis_ENSCINP00000024813 ---------PQSAGFTDENL---------SDIAVTLRRIGDDMSR--DIQLNRFIDQV---------PLKSTKDIFIKVC--L------Q----MFEDGNFNWGRIVALFYFAYRLIVR- A_carolinensis_ENSACAP00000017228 ----------------DPKT---------KQLSECLRRIGDELDG--NMELQSMIEQV---------QVYPPKEVFFRVA--A------E----MFSDGTFNWGRVVALFYFACKLVLK- G_aculeatus_ENSGACP00000006084 ---------ESGRAAPGGGL---------GDVSSALLWLGDELEYLRPNVYRNVARQLNI----TVASESIVSDAFLAVA--A------D----IFSTG-VTWGKVVSLYAVAGALAVD- O_anatinus_ENSOANP00000008963 ---------DYNVPSPGGKL---------AEVSTILLRLGDELEYIRPNVYRNIARQLNI----SLHSETVVTDAFLAVA--T------Q----IFSAG-ITWGKVVSLYAVAAGLAVD- A_aegypti_AAEL001521-PA ---------SIVGTPTIHVV---------REVFPALLSVGEELERMYPRVYNGVARQLSRIGRGELKTPETAPVLLSAIA--R------D----LFRSD-ITWGKVVSLFAIAGGLSVD- A_carolinensis_ENSACAP00000004550 ---------GAEASPDAAAV---------TSLQDCMFRIWQELSS--NRDLTSMVESA---------TGKNPLEVLADVS--E------H----LFADG-INWGRIVVFFYFAFRVIAQ- T_guttata_ENSTGUP00000006267 ---------EYNAPVPGGKL---------AEVSTILLRLGDELEYIRPNVYRNIARQLNI----SLHSETVVSDAFLAVA--T------Q----IFSAG-ITWGKVVSLYAVAAGLAVD- M_domestica_ENSMODP00000017160 ---LLDSMGDSAPLPSDPRT---------KRLTECLRRIGDELDS--NMELQRMIAAV---------ETDSPREVFFRVA--A------E----MFSDGNFNWGRVVALFYFASKLVLK- T_rubripes_ENSTRUP00000006891 -------------------------------------------------LLLSLVNQV---------QGNCAQEVFMQVA--R------S----IFSDG-INWGRVVALFHLAYRLILK- T_nigroviridis_ENSTNIP00000005841 ---------ENGPPASGGTL---------GEASAVLLWLGDELEHLRPNVYCNVARQLNI----TVASESIMSDAFLAVA--A------D----IFSTG-VTWGKVVSLYAVAGALAVD- G_gallus_ENSGALP00000009257 ---------EHNTPVPGGKL---------AEVSAILLCLGDELEYIRPNVYRNIARQLNI----SLHSETVVTDAFLAVA--A------Q----IFTAG-ITWGKVVSLYAVAAGLAVD- G_aculeatus_ENSGACP00000018053 ---------ELHLSPSSAAL---------AEVSLVLLCLGDELESIRPSLYRNVARQLNI----SVAMENMVSDAFIGVA--T------E----IFSTG-ITWGKVVSMYAVAGALAVD- M_musculus_ENSMUSP00000027499 ---------ERASPAPGGRL---------AEVCTVLLRLGDELEQIRPSVYRNVARQLHI----PLQSEPVVTDAFLAVA--G------H----IFSAG-ITWGKVVSLYSVAAGLAVD- R_norvegicus_ENSRNOP00000024693 ---------ERASPAPGGRL---------AEVCTVLLRLGDELEQIRPSVYRNVARQLHI----PLQSEPVVTDAFLAVA--G------H----IFSAG-ITWGKVVSLYSVAAGLAVD- M_musculus_ENSMUSP00000033093 ---TLEQ------PPQDAST---------KKLSECLRRIGDELDS--NMELQRMIADV---------DTDSPREVFFRVA--A------D----MFADGNFNWGRVVALFYFASKLVLK- P_troglodytes_ENSPTRP00000019323 ---ALDP------VPQDAST---------KKLSECLKRIGDELDS--NMELQRMIAAV---------DTDSPREVFFRVA--A------D----MFSDGNFNWGRVVALFYFASKLVLK- M_mulatta_ENSMMUP00000005209 ---ALDP------VPQDAST---------KRLSECLKRIGDELDS--NMELQRMIAAV---------DTDSPREVFFRVA--A------D----MFSDGNFNWGRVVALFYFASKLVLK- M_musculus_ENSMUSP00000044048 ---------SKPLGEAGAAG---------RRALETLRRVGDGVQRNHETAFQGMLRKLDI-------KNEGDVKSFSRVM--V------H----VFKDGVTNWGRIVTLISFGAFVAKH- G_aculeatus_ENSGACP00000017662 DG-ESFPRLCKRLPQSDPTA---------AATHRVLREAGDELERLYQPDFTEMSRQLYL-------TSTTAQRRFAEVI--D------E----LFRDG-VNWGRIIAFFEFGGTVCAEC T_rubripes_ENSTRUP00000012873 DR-GSISHPCKEPP-ASDQH---------AAIHRVLREAGDELERLYQPDFTEMSRQLYL-------SSTTAQRRFAEVI--D------E----LFRDG-VNWGRIIAFFEFGGAVCAEC T_guttata_ENSTGUP00000015983 -----------EPQPSSPDT---------KRLSECLRRIGDELDS--NMELQRMIEQV---------GCDAPKKLFFRVA--K------E----MFADGTFNWGRVVALFYFACKLVLK- T_rubripes_ENSTRUP00000036334 ---------------SDPNH---------KKLAQCLQKIGDELDG--NMELQRMINDS---------ALKPTKDMFMKVA--L------E----IFSDGKFNWGRVVALFYFACRLVIK- T_nigroviridis_ENSTNIP00000002788 DR-GSIPHLCKRTP-QSEQH---------AAIHRVLREAGDELERLYQPDFTEMSRQLYL-------TSTTAQRRFAEVI--D------E----LFRDG-VNWGRIIAFFEFGAAVCAEC B_taurus_ENSBTAP00000017739 ---GLEQ------VPQDAST---------KKLSECLKRIGDELDS--NMELQRMIAAV---------DTDSPREVFFRVA--A------E----MFSDGNFNWGRVVALFYFASKLVLK- R_norvegicus_ENSRNOP00000028328 ---TLEQ------PPQDAST---------KKLSECLRRIGDELDN--NMELQRMIADV---------DTDSPREVFFRVA--A------D----MFADGNFNWGRVVALFYFASKLVLK- H_sapiens_ENSP00000293288 ---ALDP------VPQDAST---------KKLSECLKRIGDELDS--NMELQRMIAAV---------DTDSPREVFFRVA--A------D----MFSDGNFNWGRVVALFYFASKLVLK- H_sapiens_ENSP00000314132 ---------ERAAPVP-GRL---------AEVCAVLLRLGDELEMIRPSVYRNVARQLHI----SLQSEPVVTDAFLAVA--G------H----IFSAG-ITWGKVVSLYAVAAGLAVD- G_gorilla_ENSGGOP00000015296 ---------ERAAPVP-GRL---------AEVCAVLLRLGDELEMIRPSVYRNVARQLHI----SLQSEPVVTDAFLAVA--G------H----IFSAG-ITWGKVVSLYAVAAGLAVD- M_mulatta_ENSMMUP00000007481 ---------ERAAPVP-GRL---------AEVCAVLLRLGDELEMIRPSVYRNVARQLHI----SLQSEPVVTDAFLAVA--G------H----IFSAG-ITWGKVVSLYAVAAGLAVD- P_pygmaeus_ENSPPYP00000014939 ---------ERAAPVP-GRL---------AEVCAVLLRLGDELEMIRPSVYRNVARQLHI----SLQSEPVVTDAFLAVA--G------H----IFSAG-ITWGKVVSLYAVAAGLAVD- M_domestica_ENSMODP00000020066 ---------EAKTPTPGGKL---------AEVASILLRLGDELEYIRPNVYRNIARQLNI----SLQSESVVTDAFLAVA--T------Q----IFAAG-ITWGKVVSLYAVAAGLAVD- A_gambiae_AGAP011552-PA ---MEHCMAGSGGLGGGAVV---------REALPILNGMGEELERMHPRLYSNVSRQISNEPWGELTEPDTVGYLLHVVA--K------D----LFKSG-ITWGKVISLFAIAGGLAVD- D_rerio_ENSDARP00000023687 ---TRSQLGGV--ELCDPSH---------KRLAQCLQQIGDELDG--NAQLQSMLNNS---------NLQPTQDVFIRVA--R------E----IFSDGKFNWGRVVALFYFACRLVIK- G_aculeatus_ENSGACP00000018700 ---TRTQLGGV--ELSDPNH---------KKLAMCLQQIGDELDG--NVELQRMMNDS---------SLGPTKDVFLKVA--F------E----IFSDGKFNWGRVVALFYFACRLVIK- T_nigroviridis_ENSTNIP00000018321 ---------ELNLSPSSTAL---------ADASMVLLCLGDELESMQPSLYRNVARQLNI----SVAMENMVSDAFIAVA--T------E----ILSTG-ITWGKVVSMYAVAGALAVD- A_carolinensis_ENSACAP00000000851 ---------EHSVPVPGGKL---------AEVSNILLRLGDELEYIRPNLYRNVARQLNI----SLHSETVVTDAFLAVA--T------Q----IFSSG-ITWGKIVSLYAVAAGLAVD- B_taurus_ENSBTAP00000011478 ---------ERAAPVPGGRL---------AEVCAVLLRLADELELIRPSVYRNVARQLNL----SLQSETVVTDAFLAVA--T------Q----IFSAG-ITWGKVVSLYSVAAGLAVD- 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000077757 VYQRGLTGF--LGQVTCFLADIILHHYIARWIAQRGGWVAALN----------------------------FRRDP-------------------------------------------- R_norvegicus_ENSRNOP00000000576 VYQRGLTGF--LGQVTCFLADIILHHYIARWIAQRGGWVAALS----------------------------LRRDP-------------------------------------------- B_taurus_ENSBTAP00000000549 VYQRGLTGF--LGQVTRFVADFMLRRSIARWIAQRGGWVAALD----------------------------LGNGP-------------------------------------------- E_caballus_ENSECAP00000021385 VYQRGLTGF--LSQLTRFVAEFMLHHCIARWIAQRGGWVAALD----------------------------LGNGP-------------------------------------------- G_gorilla_ENSGGOP00000015828 VYQHGLTGF--LGQVTRFVVDFMLHHCIARWIAQRGGWVAALN----------------------------LGNGP-------------------------------------------- P_troglodytes_ENSPTRP00000050271 VYQHGLTGF--LGQVTRFVVDFMLHHCIARWIAQRGGWVAALN----------------------------LGNGP-------------------------------------------- H_sapiens_ENSP00000363591 VYQHGLTGF--LGQVTRFVVDFMLHHCIARWIAQRGGWVAALN----------------------------LGNGP-------------------------------------------- M_mulatta_ENSMMUP00000011943 VYQHGLTGF--LGQVTRFVVDFMLHHCIARWIAQRGGWVAALN----------------------------LGNGP-------------------------------------------- C_familiaris_ENSCAFP00000001449 VYQRGLTGF--LGQVTRFVADFMLHHCIARWIAQRGGWVAALN----------------------------LGNGP-------------------------------------------- P_pygmaeus_ENSPPYP00000006150 VYHRGLTGF--LGQVTRFVVDFMLHHCIARWIAQRGGWVAALN----------------------------LGNGP-------------------------------------------- O_cuniculus_ENSOCUP00000002204 IYRRGLTGF--LGQVTRFVADFVVHHCIAQWIAQRGGWVAVLS----------------------------SHN-P-------------------------------------------- M_domestica_ENSMODP00000017616 VYQRGLTGF--LGRVAHFVADFMLHHCIARWIAQNGGWVAALN----------------------------LTNNS-------------------------------------------- A_carolinensis_ENSACAP00000016202 VYQHGMTGF--LRRIARYMADFVLRNRIARWIAQQGGWVAALD----------------------------LSNVY-------------------------------------------- P_pygmaeus_ENSPPYP00000018457 VYQRGLTGF--LGQVTRFVVDFMLHHCIARWIAQRGGWVAALN----------------------------LGNGP-------------------------------------------- G_gallus_ENSGALP00000039057 VYQQGITGF--LRRIARYVTEFMLRNRIARWIAQQGGWVAALD----------------------------LDNVY-------------------------------------------- X_tropicalis_ENSXETP00000056677 VVRNGQRGF--FRIINQWMVRYVMESCIAQWISSRGGWVAFFQ----------------------------LTNYS-------------------------------------------- T_guttata_ENSTGUP00000001882 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000024313 SVDKEMEVL--VGRITSWMATY-LDDHLDPWIQENGGWDTFVE----------------------------LYGNDAAAESRKGQ----------------------------------- E_caballus_ENSECAP00000014770 SVDKEMQVL--VSRIATWMATY-LNDHLEPWIQENGGWDTFVE----------------------------LYGNNAAAESRKGQ----------------------------------- B_taurus_ENSBTAP00000008572 SVDKEMQVL--VSRIATWMATY-LNDHLEPWIQENGGWDTFVE----------------------------LYGNNAAAESRKGQ----------------------------------- M_mulatta_ENSMMUP00000007865 SVDKEMQVL--VSRIAAWMATY-LNDHLEPWIQENGGWDTFVE----------------------------LYGNNAAAESRKGQ----------------------------------- C_familiaris_ENSCAFP00000010478 SVDKEMQVL--VSRIAAWMATY-LNDHLEPWIQENGGWDTFVE----------------------------LYGNNAAAESRKGQ----------------------------------- H_sapiens_ENSP00000365230 SVDKEMQVL--VSRIAAWMATY-LNDHLEPWIQENGGWDTFVE----------------------------LYGNNAAAESRKGQ----------------------------------- P_pygmaeus_ENSPPYP00000012163 SVDKEMQVL--VSRIAAWMATY-LNDHLEPWIQENGGWDTFVE----------------------------LYGNNAAAESRKGQ----------------------------------- P_troglodytes_ENSPTRP00000022903 SVDKEMQVL--VSRIAAWMATY-LNDHLEPWIQENGGWDTFVE----------------------------LYGNNAAAESRKGQ----------------------------------- T_nigroviridis_ENSTNIP00000017211 ALTTNHLEN--IRTVIGWVLQV-IREQLYSWLVQQGGWAGVIQ----------------------------RFA---------------------------------------------- T_rubripes_ENSTRUP00000014135 CVEKEMSPL--VGRIIEWMTVY-LDNHIQPWIQSQGGWVRFAE----------------------------LFGQDAAAESRRSQ----------------------------------- R_norvegicus_ENSRNOP00000040259 SVDKEMQVL--VSRIASWMATY-LNDHLEPWIQENGGWVRTTP----------------------------LVCPPLVCLSSVEIPNCPFWSPGMVVEDIDYSGDIPGFTLIPGVNFGNI T_nigroviridis_ENSTNIP00000007577 CVEKEMNPL--VGRIIEWMTVY-LDNHIQPWIQSQGGWERFAE----------------------------LFGQDAAAESRRSQ----------------------------------- A_carolinensis_ENSACAP00000011187 SVDKEMQGL--VVRIASWMTTY-LTEHLDPWIQENGGWERFVD----------------------------VYGNDAAAKSRKGQ----------------------------------- A_carolinensis_ENSACAP00000017311 SVSREMSPL--VDNIATWMTEY-LNQYLRNWIQENGGW---------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000002775 SVDKEMEVL--VSRIAAWMATY-LNDHLEPWIQENGGW---------------------------------------------------------------------------------- G_gallus_ENSGALP00000010059 SVDKEMRVL--VGRIVSWMTTY-LTDHLDPWIQENGGWERFVD----------------------------LYGNNAAAELRKGQ----------------------------------- G_aculeatus_ENSGACP00000018978 ALTTNHLEN--IRIIIGWVLRF-IRERLYPWLVQQGGWVGVIN----------------------------GFS---------------------------------------------- M_musculus_ENSMUSP00000086454 SVDKEMQVL--VSRIASWMATY-LNDHLEPWIQENGGW-----------------------------------GVSGGTPLR-------------------------------------- G_gallus_ENSGALP00000020984 SVNREMSPL--VDNIATWMTEY-LNRHLHNWIQDNGGWDAFVE----------------------------LYGNSMRPLFDFSW----------------------------------- O_latipes_ENSORLP00000017513 CVERNMGEL--VSRIAEWMTQY-LDEQISPWIHSHGGWDCFAR----------------------------LYGQNGAAEARRFQ----------------------------------- D_rerio_ENSDARP00000089067 ALTQNHLEI--IKNIISWFLQF-MKKHISAWIRQQGGWEGIFR----------------------------SMT---------------------------------------------- B_taurus_ENSBTAP00000026248 SVNKEMEPL--VGQVQEWMVAY-LETRLADWIHSSGGWAEFTA----------------------------LYGDGALEEARRLR----------------------------------- E_caballus_ENSECAP00000008404 SVNKEMEPL--VGQVQEWMVAY-LETRLADWIHSSGGWAEFTA----------------------------LYGDGALEEARRLR----------------------------------- P_troglodytes_ENSPTRP00000010457 SVNKEMEPL--VGQVQEWMVAY-LETRLADWIHSSGGWAEFTA----------------------------LYGDGALEEARRLR----------------------------------- H_sapiens_ENSP00000250405 SVNKEMEPL--VGQVQEWMVAY-LETQLADWIHSSGGWAEFTA----------------------------LYGDGALEEARRLR----------------------------------- M_mulatta_ENSMMUP00000019355 SVNKEMEPL--VGQVQEWMVAY-LETRLADWIHSSGGWAEFTA----------------------------LYGDG-LEEARRLR----------------------------------- G_gorilla_ENSGGOP00000001415 SVNKEMEPL--VGQVQEWMVAY-LETRLADWIHSSGGWAEFT------------------------------------------------------------------------------ B_taurus_ENSBTAP00000025701 SVNREMSPL--VDSIALWMTEY-LNRHLHTWIQDNGGWVGARL----------------------------DVSLSGTPRSQCGPSGGVWLGPGSRAGRWSK------------------ D_rerio_ENSDARP00000095258 CVEKEMSPL--VGRIAEWMTVY-LDNHIQPWIQSQGGWERFAE----------------------------IFGKDAAAESRKSQ----------------------------------- T_guttata_ENSTGUP00000006866 SVVKEMRVL--VKRIVSWMTTY-LTDHLDPWIQENGGWERFVD----------------------------SM-NDAAAEMRKGQ----------------------------------- M_domestica_ENSMODP00000005598 SVNKEMEPL--VGQVQDWMVTY-LETQLADWIHSSGGWAEFTA----------------------------LYGDGALEEARRLR----------------------------------- M_musculus_ENSMUSP00000022806 SVNKEMEPL--VGQVQDWMVAY-LETRLADWIHSSGGWAEFTA----------------------------LYGDGALEEARRLR----------------------------------- G_aculeatus_ENSGACP00000005643 CVDKEMSPL--VGRIVEWMTLY-LDNHIQPWIQNQGGWRSDI------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000008651 SVNREMSPL--VDNIALWMTEY-LNRHLHTWIQDNGGWDAFVE----------------------------LYGPSMRPLFDFSW----------------------------------- O_anatinus_ENSOANP00000014671 SVNKEMEPL--VGQVQDWMVAY-LDTQLADWIRSSGGWAEFTA----------------------------LYGDGALEDARRLR----------------------------------- P_pygmaeus_ENSPPYP00000010339 SVNREMSPL--VDNIALWMTEY-LNRHLHTWIQDNGGWDAFVE----------------------------LYGPSMRPLFDFSW----------------------------------- H_sapiens_ENSP00000381185 SVNREMSPL--VDNIALWMTEY-LNRHLHTWIQDNGGWDAFVE----------------------------LYGPSMRPLFDFSW----------------------------------- P_troglodytes_ENSPTRP00000017121 SVNREMSPL--VDNIALWMTEY-LNRHLHTWIQDNGGWDAFVE----------------------------LYGPSMRPLFDFSW----------------------------------- R_norvegicus_ENSRNOP00000003768 SVNREMSPL--VDNIALWMTEY-LNRHLHTWIQDNGGWDAFVE----------------------------LYGPSMRPLFDFSW----------------------------------- M_musculus_ENSMUSP00000108371 SVNREMSPL--VDNIALWMTEY-LNRHLHTWIQDNGGWDAFVE----------------------------LYGPSMRPLFDFSW----------------------------------- G_gorilla_ENSGGOP00000000778 SVNREMSPL--VDNIALWMTEY-LNRHLHTWIQDNGGWXXXXE----------------------------LYGPSMRPLFDFSW----------------------------------- T_guttata_ENSTGUP00000002093 SVNREMFPL--VDNIATWMTEY-LNRHLHNWIQDNGGWDAFVE----------------------------LYGNNMRPLFDFSW----------------------------------- E_caballus_ENSECAP00000017850 SVNREMSPL--VDNIALWMTEY-LNRHLHTWIQDNGGWDAFVE----------------------------LYGPSMRPLFDFSW----------------------------------- M_domestica_ENSMODP00000006458 SVNREMSPL--VDSIALWMTEY-LNRHLHTWIQDNGGWDAFVE----------------------------LYGNSMRPLFDFSW----------------------------------- D_rerio_ENSDARP00000096467 SVNREMASQ--VDNIAHWMTDY-LNGPLENWIEENGGWDAFVE----------------------------MYGQQRDSVFHPFS----------------------------------- X_tropicalis_ENSXETP00000031936 SVNKEMSPL--LPRIQDWMVTY-LETNLRDWIQSNGGWNGFLT----------------------------LYGDGAIEEARRQR----------------------------------- T_rubripes_ENSTRUP00000032199 CVEKDASQL--VCRIADWMTIY-LDEHINPWIQSQGGWDCFAK----------------------------IFGDDAAAEGRRAR----------------------------------- R_norvegicus_ENSRNOP00000056470 SVNKEMEAL--VGQVQDWMVAY-LETCLTDWIDSSGGWVEFTA----------------------------QYEDGALEEA--------------------------------------- C_familiaris_ENSCAFP00000000102 SVNREMSPL--VDNIALWMTEY-LNRHLHTWIQDNGGWVGARL----------------------------LEWESG------------------------------------------- X_tropicalis_ENSXETP00000053903 SANKEMTEL--LP