10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000086454 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000010478 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000365230 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000012163 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000022903 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000007865 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000014770 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000008572 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002775 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000040259 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000024313 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000010059 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006866 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011187 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000024954 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000095258 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000014135 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005643 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000007577 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000032199 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000010122 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000020984 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000017311 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000003768 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000002093 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108371 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013488 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000008651 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000017513 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381185 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000017121 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017850 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000010339 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000000778 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000053903 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000006458 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000000102 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000096467 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000052058 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000025701 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000031936 --------------------------------------------------------------------------------------------------------------------RKKG O_latipes_ENSORLP00000021005 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000014671 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000022806 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250405 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000026248 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000008404 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010457 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005598 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000001415 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000012873 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000019355 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000017662 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000002788 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000056470 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013781 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000036532 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000037249 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000012299 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000033198 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005426 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000016202 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000056677 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000077757 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000017616 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000000576 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000050759 ---------------------------------------------------------------------------------------------------------------MATHGAGGD E_caballus_ENSECAP00000021385 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000000549 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000017228 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL001521-PA -------------------------------------------------------MLSAEAPVSHNHHLLPDRLSAPALA--------RRKFSFPANLHSTVLHGDPPGSINSGSLQ-PS O_latipes_ENSORLP00000005745 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000023687 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000039057 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000036334 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002204 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018700 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000363591 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000015828 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000050271 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0087182 --------------------------------------------------------MPGTSYPTNNDNFSNGFPMATTQSERLLQAQNRRKFSFPATLHSASLLEVGGG----------- A_carolinensis_ENSACAP00000004550 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000006084 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000001449 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000037180 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000028328 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000017160 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000033093 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000011943 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000006150 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005841 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000017739 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018053 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011552-PA -----------------------------------------------------------MSST----------AGAFHQQHQPQQQSPRSPIVAAAVAAAAAIGAVSGG----------- H_sapiens_ENSP00000314132 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000015296 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000007481 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014939 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000020066 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000019323 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000000851 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000005209 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008963 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000068408 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000017211 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000027499 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000024693 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018978 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000293288 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000052069 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000013345 --------------------MFA-------------------GRNNDNGFWPCTGLQSKPLVI-------------------------------------------------------PE T_guttata_ENSTGUP00000006267 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000015664 ------MALSLDFRRTATMSFFAQGVQTPTLKTCVEDELDGYIEEEEAPLKRLR----------------------------------------------------------------PG O_cuniculus_ENSOCUP00000005553 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000000977 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000018321 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000011478 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0085443 -----------------------------------------------------------MAPTTSPPPKLAKF-KSSSLDHEIYTANRRGTIATASSDWKALRGGVGGGAGGPGSVPNPS T_guttata_ENSTGUP00000008329 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000009257 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000010113 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL001515-PA -----------------------------------------------------------MEMT--------------------------------------------------------- D_rerio_ENSDARP00000040899 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000010509 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000000654 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008571 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000044048 MFGLRRNAVIGLNLYCGGASLGAGGGSPAGARLVAEEAKARREGGGEAALLPGARVVARPPPVGAEDPDVTASAERRLHKSPGLLAVPPEEMAASAAAAIVSPEEELDGCEPEAIGKRPA T_rubripes_ENSTRUP00000030263 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000001847 ------DSP----KRPSKLSVIAP-------KVCVAKAIQEDSQDTDHRSAPCT----------------------------------------------------------------PE M_domestica_ENSMODP00000026730 ------------------------------------------------------------------------------------------------------------------------ 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000086454 ------------------------------------MSQSNRELVVDFLSYKLSQ---KGYSWSQFS-DVEENRTEAP-----EETEAERETPSAI----------NGNPSWHLADSPAV C_familiaris_ENSCAFP00000010478 ------------------------------------MSQSNRELVVDFLSYKLSQ---KGYSWSQFS-DVEENRTEAP-----EGTESEMETPSAI----------NGNPSWHLADSPAV H_sapiens_ENSP00000365230 ------------------------------------MSQSNRELVVDFLSYKLSQ---KGYSWSQFS-DVEENRTEAP-----EGTESEMETPSAI----------NGNPSWHLADSPAV P_pygmaeus_ENSPPYP00000012163 ------------------------------------MSQSNRELVVDFLSYKLSQ---KGYSWSQFS-DVEENRTEAP-----EGTESEMETPSAI----------NGNPSWHLADSPAV P_troglodytes_ENSPTRP00000022903 ------------------------------------MSQSNRELVVDFLSYKLSQ---KGYSWSQFS-DVEENRTEAP-----EGTESEMETPSAI----------NGNPSWHLADSPAV M_mulatta_ENSMMUP00000007865 ------------------------------------MSQSNRELVVDFLSYKLSQ---KGYSWSQFS-DVEENRTEAP-----EGTESEMETPSAI----------NGNPSWHLVDSPAV E_caballus_ENSECAP00000014770 ------------------------------------MSQSNRELVVDFLSYKLSQ---KGYNWSQFS-DVEENRTEAP-----EGTESEMETPSAI----------NGNPSWHLADSPTG B_taurus_ENSBTAP00000008572 ------------------------------------MSQSNRELVVDFLSYKLSQ---KGYSWSQFS-DVEENRTEAP-----EGTESDMETPSAI----------NGNASWHLADSPAV O_cuniculus_ENSOCUP00000002775 ------------------------------------MSQSNRELVVDFLSYKLSQ---KGYSWSQFS-DVEENRTEAP-----EGTGPEMETPSAI----------NGNPAWHPADSPAV R_norvegicus_ENSRNOP00000040259 ------------------------------------MSQSNRELVVDFLSYKLSQ---KGYSWSQFS-DVEENRTEAP-----EETEPERETPSAI----------NGNPSWHLADSPAV M_domestica_ENSMODP00000024313 ------------------------------------MSHSNRELVIDFLSYKLSQ---KGYNWSQFE-D--ENRTEVL-----EGA----EIPSTV----------NGSPSWHPADSRAV G_gallus_ENSGALP00000010059 ------------------------------------MSSSNRELVIDFVSYKLSQ---RGHCWSELE-EEDENRTDTA-----A----EAEMDSVL----------NGSPSWHPPAGHVV T_guttata_ENSTGUP00000006866 ------------------------------------MYSSNRELVIDFVSYKLSQ---KGYSWSQLE-EEDENRTDFA-----GE---EDEMDGVL----------NGSPSWHAATSHIV A_carolinensis_ENSACAP00000011187 ------------------------------------MSSSNRALVVDFLSYKLSQ---RGHSWHEIE------MESGE-----EAMEPANETGNTL----------NGSPSWHPSPSHVI R_norvegicus_ENSRNOP00000024954 ------------------------------------MSQSNRELVVDFLSYKLSQ---KGYSWSQFS-DVEENRTEAP-----EETEPERETPSAI----------NGNPSWHLADSPEV D_rerio_ENSDARP00000095258 ------------------------------------MSYYNRELVVFFIKYKLSQ---RNYPCNHIG-LTEDTNRTDG-----AEENGE-GAAGATTLVNGTMNRTNASSTGTPPQSPAS T_rubripes_ENSTRUP00000014135 ------------------------------------MS-QNRELVIFYIKYKLSQ---RNYPFNHNGLILEPPSRTDG--------------QFVTTQFNGTF---NGASPGTPPA---- G_aculeatus_ENSGACP00000005643 ------------------------------------MS-QNRELVVFYINYKLSQ---RNLPLNHIG-LSEPPNRTGG-----GVEAGAAGGQRGATHSNGTF---NGTSPGTPPASPL- T_nigroviridis_ENSTNIP00000007577 ---------------------RSHPGAKSKGASTQRMS-LNRELVIFYIKYKLSQ---RNYPLSH---IVEPSSRTEG--------------QFGTTQSNGTF---NGASPGTPPA---- T_rubripes_ENSTRUP00000032199 ------------------------------------MSYNNRELVEHFLRYKLSQ---RNYPTSLLR-PEDTDGRTEG-----EKRSPGASNGLLV----------RSRNRGGAS----- T_nigroviridis_ENSTNIP00000010122 ------------------------------------MSYDNRELVEYFLGYKLAQ---RNYPSSLLR-PQEPDGWTEG-----DKKSPAAVNGLLI----------RNRSRSGAS----- G_gallus_ENSGALP00000020984 ------------------------------MAHPGRRGYDNREIVLKYIHYKLSQ---RGYDWA----AGEDRPPVPP--------APAPAAAPAA----------VAAAGAS------- A_carolinensis_ENSACAP00000017311 ------------------------------MAHPGIRGYDNREIVLRYIHYKLSQ---KGYDWVASGDRGN--LAAAA-----AAAAATPSAPTVS------------------------ R_norvegicus_ENSRNOP00000003768 ------------------------------MAQAGRTGYDNREIVMKYIHYKLSQ---RGYEWD----TGD--EDSAP-----LRAAPTPGIFSFQ----------PESNRTPAVHRD-- T_guttata_ENSTGUP00000002093 ------------------------------MAHPGRRGYDNREIVLKYIHYKLSQ---RGYDWA----AGEDRASLPP----DHSASAAAAIAAAA----------IAAAGTSDHTGL-- M_musculus_ENSMUSP00000108371 ------------------------------MAQAGRTGYDNREIVMKYIHYKLSQ---RGYEWD----AGD--ADAAP-----LGAAPTPGIFSFQ----------PESNPMPAVHRD-- G_aculeatus_ENSGACP00000013488 ------------------------------------MANINRELVEFFLSYKLSQ---KNHPTSLLR-PEDAGGRTEG-----DKANSASVPGRGS----------SAGQPGMSSPP--- M_mulatta_ENSMMUP00000008651 ------------------------------MAHAGRTGYDNREIVMKYIHYKLSQ---RGYEWD----AGD--VGAAT-----PGAAPAPGIFSSQ----------PGHTPHPAASRD-- O_latipes_ENSORLP00000017513 --------------------------------QAHTMSHCNRELVRFYLAYKMSC---RDYPVSLLK-PTDDGGETEE-----DHSDAR---NRRL----------VSSEDGRLRRS--- H_sapiens_ENSP00000381185 ------------------------------MAHAGRTGYDNREIVMKYIHYKLSQ---RGYEWD----AGD--VGAAP-----PGAAPAPGIFSSQ----------PGHTPHPAASRD-- P_troglodytes_ENSPTRP00000017121 ------------------------------MAHAGRTGYDNREIVMKYIHYKLSQ---RGYEWD----AGD--VGAAP-----PGAAPAPGIFSSQ----------PGHTPHPAASRD-- E_caballus_ENSECAP00000017850 ------------------------------MAHAGRTGYDNREIVMKYIHYKLSQ---RGYEWD----AGD--AGAAP-----LGATPVPGIFSSQ----------PGRTPAP------- P_pygmaeus_ENSPPYP00000010339 ------------------------------MAHAGTTGYDNREIVDEXIHYKLSQ---RGYEWD----AGD--VGAAP-----PGAATAPGIFSSQ----------PGHTPHPAASRD-- G_gorilla_ENSGGOP00000000778 ------------------------------MAHAGRTGYDNREIVMKYIHYKLSQ---RGYEWD----AGD--VGAVP-----PGAAPAPGIFSSQ----------PGHTPHPAASRD-- X_tropicalis_ENSXETP00000053903 ------------------------------------MEGSSRDLVEKFVCKKLSQ---KGACGEFSS-NSQPKGVSNG-----SSEGPG------------------------------- M_domestica_ENSMODP00000006458 ------------------------------MAHPGRRGYDNREIVMKYIHYKLSQ---RGYEWD----AGDLRAPASPSLPPVVASAPAVGIFSTQ----------PRNTPLPAEPQDSA C_familiaris_ENSCAFP00000000102 ------------------------------MAHAGRTGYDNREIVMKYIHYKLSQ---RGYEWD----AGE--AGAAP-----PGAAPAPGI---------------------------- D_rerio_ENSDARP00000096467 --------------------------------MANEISYDNRNIVEKYLKHKLSK---RGYVWKCQS-SAEEDDTFNK-----AVEESSPNSDRRL----------QAPSAGGGNNSECL X_tropicalis_ENSXETP00000052058 ------------------------------MAHPRRGGYDHRDIVVKYIHYKLSQ---KGYEW----EEGRQQVSAEH-----PQASAAISNYSDD-------------GEMPAASAD-- B_taurus_ENSBTAP00000025701 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000031936 NNGVKDRDWEEQHATGNIIFRGSPDKYLTEQGWMAQSELGSRALVEDFVRYKLCQ---RSLVP--------------------------------------------------------- O_latipes_ENSORLP00000021005 -----------------------------------MANVSNRSIVEKYICHKLSK---RGYVCGLNG-GQRENAANNG-----SVGDHS------------------------------- O_anatinus_ENSOANP00000014671 -------------------------AAPRMATPAPASVSDTRALVADFVGYKLRQ---KGF----------------------------------------------------------- M_musculus_ENSMUSP00000022806 -------------------------------MATPASTPDTRALVADFVGYKLRQ---KGYVCGAG------------------------------------------------------ H_sapiens_ENSP00000250405 -------------------------------MATPASAPDTRALVADFVGYKLRQ---KGYVCGAG------------------------------------------------------ B_taurus_ENSBTAP00000026248 -------------------------------MATPASAPDTRALVADFVGYKLRQ---KGYVCGAG------------------------------------------------------ E_caballus_ENSECAP00000008404 -------------------------------MATPASAPDTRALVADFVGYKLRQ---KGYVCGAG------------------------------------------------------ P_troglodytes_ENSPTRP00000010457 -------------------------------MATPASAPDTRALVADFVGYKLRQ---KGYVCGAG------------------------------------------------------ M_domestica_ENSMODP00000005598 -------------------------------MATPASAPDTRALVADFVGYKLRQ---KGYACGTG------------------------------------------------------ G_gorilla_ENSGGOP00000001415 -------------------------------MATPASAPDTRALVADFVGYKLRQ---KGYVCGAG------------------------------------------------------ T_rubripes_ENSTRUP00000012873 --------------------------------QVGMERECNRDIVENYICHKLSK---RGFAWSFED-VQDENAANNG-----SVVAPAPTLVRRC----------HEAGTGPDRDRGSI M_mulatta_ENSMMUP00000019355 -------------------------------MATPASAPDTRALVADFVGYKLRQ---KGYVCGAG------------------------------------------------------ G_aculeatus_ENSGACP00000017662 -----------------------------------MSNECNRHIVEKYICHKLSK---RGYAFGFDD-VGEEDAASNG-----SMVVPPPTAVRRC----------REAGP----DGESF T_nigroviridis_ENSTNIP00000002788 -----------------------------------MAREYNRDIVEKYIFHKLSK---RGFVWRFEE-VQDQNAANNG-----SVVAPAPTLVRRC----------HEAGTGP--DRGSI R_norvegicus_ENSRNOP00000056470 ---------------------------------IPVSTPDTWALVADFVGYKLSG---AG------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013781 ------------------------------------MSHTNRELVEFYLNYKLSH---SNFLTSLRASADAWQSPRIS-----RRDRSGAS----------------------------- T_rubripes_ENSTRUP00000036532 --------------------------------------MSNRELVENYLIYKLSQ---KNYPGTLLR-PKDASSGLLV-----DRESSGTS----------------------------- M_domestica_ENSMODP00000037249 -------------------------------LYTHMIPAGIQALMADFVNYKLKQ---NGYVSRTC------------------------------------------------------ T_rubripes_ENSTRUP00000012299 -------------------------------------------------------------SGTLLR-PKGASSGLLV-----DRESSGAS----------------------------- T_rubripes_ENSTRUP00000033198 ----------------------------------------NRELVENYLIYKLSQ---KNYPGTLLR-PKDALSGLLV-----DRESSGAS----------------------------- T_rubripes_ENSTRUP00000005426 --------------------------------------MSNRELVENYLIYKLSQ---K-YPGTVS------------------------------------------------------ A_carolinensis_ENSACAP00000016202 ------------------------------A--EDQVAQETEEVFQSYAFYRYQQ---EREQTEGDV-PHDPEIAAIP------------------------------------------ X_tropicalis_ENSXETP00000056677 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000077757 ---MASGQGPGPPK-----VGCDE--SPSPS--EQQVAQDTEEVFRSYVFYLHQQ---EQETQGAAA-PANPEMDNLP------------------------------------------ M_domestica_ENSMODP00000017616 ------------------------------T--EEQVARETEEVFRSYVYYRHQQ---EQETEGEAV-PADPEMDTLP------------------------------------------ R_norvegicus_ENSRNOP00000000576 ---MASGQGPGPPK-----GDCDE--ALSAS--EQQVAQDTEEVFRSYVFYLHQQ---EQETQGAAA-PANPEMDNLS------------------------------------------ X_tropicalis_ENSXETP00000050759 YPGEDKEKNQGEGGAAGGPSLGAAGDRSGTGVSTEQILETGELLLNGFISDRLQNNPDVAGARALFPGST-------------------------------------------------- E_caballus_ENSECAP00000021385 ---MASGQGPGPPG-----KECGEPAPSSTS--EEQVARDTEEVFRSYVYYRHQQ---EQEAEGAAA-PADPEMDTLP------------------------------------------ B_taurus_ENSBTAP00000000549 ---MASGQGPGPPG-----QDCDEPDPSSTS--EEQVARDTEEVFRSYVFYRHQQ---EQEAEGAAA-PTDPEMVTLH------------------------------------------ A_carolinensis_ENSACAP00000017228 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL001521-PA STASFARRRLSNVSDVVTRKLSSTIGWKQPVLPSQDIITQGKCLCGQYIRCRLKK---SGVFNRKLGLQRIRSIVG-------------------------------------------- O_latipes_ENSORLP00000005745 --------------------MASHPGGGDQ-EKSKELLDVGTKLLKNFICERVRR---NLQDDSEVVRQQLGAE---------------------------------------------- D_rerio_ENSDARP00000023687 --------------------MAAPSGGGDTGSGNDQILDLGAALLNNFVYERVRR---HGDRDAEVTRSQLGGV---------------------------------------------- G_gallus_ENSGALP00000039057 ---MEGNEGDPPGAHRRRDSHGRRPSREINA--EDQVAQETEEVFRSYTFYRYQQ---EREEGGAEV-PMDPEIMEIQ------------------------------------------ T_rubripes_ENSTRUP00000036334 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002204 ----------------------------------QQVARDTEEVFRSYVFHRHRQ---EQEAEGAAA-PADPEMISLH------------------------------------------ G_aculeatus_ENSGACP00000018700 --------------------MASHPGGGDQGNNKDQILELGTVLLKDFIFERVKR---HGDSTETVTRTQLGGV---------------------------------------------- H_sapiens_ENSP00000363591 ---MASGQGPGPPR-----QECGEPALPSAS--EEQVAQDTEEVFRSYVFYRHQQ---EQEAEGVAA-PADPEMVTLP------------------------------------------ G_gorilla_ENSGGOP00000015828 ---MASGQGPGPPR-----QECGEPALPSAS--EEQVAQDTEEVFRSYVFYRHQQ---EQEAEGAAA-PADPEMVTLP------------------------------------------ P_troglodytes_ENSPTRP00000050271 ---MASGQGPGPPR-----QECGEPALPSAS--EEQVAQDTEEVFRSYVFYRHQQ---EQEAEGAAA-PADPEMVTLP------------------------------------------ D_melanogaster_FBpp0087182 -PKETTRRRLSNVSDAVTRKLSYTIGWKAAQIPAQDIISQGRCLCGHYIKRRLRR---SGLFNKKLGLQRIRSILG-------------------------------------------- A_carolinensis_ENSACAP00000004550 ----------------------------------------GAEA---------------------------------------------------------------------------- G_aculeatus_ENSGACP00000006084 ----------MDMLRRSSVFAA---EVFDRSPTDKELVSQAKALCRDYIHSRLNR---AGMGWSKPE-SGR------------------------------------------------- C_familiaris_ENSCAFP00000001449 ---MASGQGPGPPR-----RECGEAAPSSTS--EEQVARDTEEVFRSYVFYRHRQ---EQEAEGAAV-PADPEMVTLP------------------------------------------ D_rerio_ENSDARP00000037180 -----MKIVSYEISPLFAQLSWRAQSDIAGRKMSCWLREQTLLLAEDYISFCSGI----------------------------------------------------------------- R_norvegicus_ENSRNOP00000028328 -----------------MDGSGDH-LGGGGPTSSEQIMKTGAFLLQGFIQDRAER---MAGETPELTLEQ-------------------------------------------------- M_domestica_ENSMODP00000017160 -----------------MDGSGEQPRGGAGATSSEQIMRTGAVLLQGFIQDRAGR---VAGGAPELLLDSMGDSAP-------------------------------------------- M_musculus_ENSMUSP00000033093 -----------------MDGSGEQ-LGSGGPTSSEQIMKTGAFLLQGFIQDRAGR---MAGETPELTLEQ-------------------------------------------------- M_mulatta_ENSMMUP00000011943 ---MASGQGPGPPR-----QECGEPALPSASGKEEQVARDTEEVFRSYVFYRHQQ---EQEAEGAAA-PADPEMDTLP------------------------------------------ P_pygmaeus_ENSPPYP00000006150 ---MASGQGPGPPR-----QECGEPALPSAS--EEQVARDTEEVFRSNVFHRHQQ---EQEAEGAAA-PADPEMVTLP------------------------------------------ T_nigroviridis_ENSTNIP00000005841 ----------MEMLRRSSMFAA---EVFDRSPTDKELVSQAKALCRDYIHSRLNR---AGIGWSKAE-NGP------------------------------------------------- B_taurus_ENSBTAP00000017739 -----------------MDGSGEQ-PRGGGPTSSEQIMKTGALLLQGFIQDRAGR---MGGETPELGLEQ-------------------------------------------------- G_aculeatus_ENSGACP00000018053 ----------MEVLRRPSVMAAEVLDVFDRSLTEKELVSQSKALCRDYILSRLHQ---NGQGWSKTE-LHL------------------------------------------------- A_gambiae_AGAP011552-PA -------------SAGGVVGWTNKRSPIHHLTTSQDVINQGKCLCGEYIRARLKR---SGLLNRKIL-QRLRNSMEHC-----MAGSGG------------------------------- H_sapiens_ENSP00000314132 ----------MEVLRRSSVFAAEIMDAFDRSPTDKELVAQAKALGREYVHARLLR---AGLSWSAPE-RAA------------------------------------------------- G_gorilla_ENSGGOP00000015296 ----------MEVLRRSSVFAAEIMDAFDRSPTDKELVAQAKALGREYVHARLLR---AGLSWSAPE-RAA------------------------------------------------- M_mulatta_ENSMMUP00000007481 ----------MEVLRRSSVFAAEIMDAFDRSPTDKELVAQAKALGREYVHARLLR---AGLSWSAPE-RAA------------------------------------------------- P_pygmaeus_ENSPPYP00000014939 ----------MEVLRRSSVFAAEIMDAFDRSPTDKELVAQAKALGREYVHARLLR---AGLSWSAPE-RAA------------------------------------------------- M_domestica_ENSMODP00000020066 ----------MEVLRRSSVFAAEVMEVFDRSPTDKELVSQAKALGREYIHSRLIR---AGLVWSKPE-AKT------------------------------------------------- P_troglodytes_ENSPTRP00000019323 -----------------MDGSGEQ-PRGGGPTSSEQIMKTGALLLQGFIQDRAGR---MRGEAPELALDP-------------------------------------------------- A_carolinensis_ENSACAP00000000851 ----------MDVLRRSSVFAAEVMEVFDRTPTDKELVSQAKVLCRDFIHSRLIR---AGIGWNKPE-HSV------------------------------------------------- M_mulatta_ENSMMUP00000005209 -----------------MDGSGEQ-PRGGGPTSSEQIMKTGALLLQGFIQDRAGR---MGGETPELALDP-------------------------------------------------- O_anatinus_ENSOANP00000008963 ----------MEVLRRSSVFAAEVMEVFDRSPTDKELVSQAKALCREYIHSRLIR---ASLVWSKPD-YNV------------------------------------------------- D_rerio_ENSDARP00000068408 ----------MEMLRRSSVFAAEVMEVFDRSPTDKELVSQSKVLCRDYIHSRLHR---AGIGWSKPE-HG-------------------------------------------------- T_nigroviridis_ENSTNIP00000017211 ------------------------------DVVDDPILEQGAVVLRGYVIERIHV---EQPSLHVSS-EDLGGRSE-------------------------------------------- M_musculus_ENSMUSP00000027499 ----------MEVLRRSSVFAAEIMDAFDRSPTDKELVAQAKALGREYVHARLLR---AGLSWSAPE-RAS------------------------------------------------- R_norvegicus_ENSRNOP00000024693 ----------MEVLRRSSVFAAEIMDAFDRSPTDKELVAQAKALGREYVHARLLR---AGLSWSAPE-RAS------------------------------------------------- G_aculeatus_ENSGACP00000018978 -------MADGGREKQDDGDREPRGAEGGEDVVDDPIMEQGAVVLRGYVVSRINA---EDPSRHVSP-EQLGGRPN-------------------------------------------- H_sapiens_ENSP00000293288 -----------------MDGSGEQ-PRGGGPTSSEQIMKTGALLLQGFIQDRAGR---MGGEAPELALDP-------------------------------------------------- R_norvegicus_ENSRNOP00000052069 -----------------MDGSGDQ-LGGGGPTSSEQFMKTGAFLLQGFIQDRAER---MAGETPELTLEQ-------------------------------------------------- D_rerio_ENSDARP00000013345 LKAHNQFA-----VDSLQGSVPSSPSDETGDYPPTALDMDTREIIDTFLKIFTGL----------------------------------------------------------------- T_guttata_ENSTGUP00000006267 ----------MEVLRRSSVFAAEVMEVFDRSPTDKELVSQAKALCRDYINSRLIQ---AGVSWSKPE-YNA------------------------------------------------- D_rerio_ENSDARP00000015664 TNGLKGLQLDGRFVSATDGSLPTTPDPEELDY--AELERDTRQLLLDFYRTHTGM----------------------------------------------------------------- O_cuniculus_ENSOCUP00000005553 -----------------MDGSGEQ-SRGGGPTSSEQIMKTGALLLQGFIQDRASR---MGGQTPELAVAQ-------------------------------------------------- B_taurus_ENSBTAP00000000977 --------------------------------MTDTEFGYVHGLAEDYLKYVLQI----------------------------------------------------------------- T_nigroviridis_ENSTNIP00000018321 ----------MEVLRRSSVFAAEVLDVFDRSLTEKELVSHSKALCRDYILSRLTQ---SGLGWSKSE-LNL------------------------------------------------- B_taurus_ENSBTAP00000011478 ----------MEVLRRSSVFAAEIMDAFDRSPTDKELVAQAKALGREFVHARLLR---AGLSWSAPE-RAA------------------------------------------------- D_melanogaster_FBpp0085443 NGRSLHAGGPMTRAASTSSLASSTRTMTNYQEYKMDIINQGKCLCGQYIRARLRR---AGVLNRKVT-QRLRNILD-------------------------------------------- T_guttata_ENSTGUP00000008329 --------------------------------METAEFYYVYYLAQDYLQYVLQE----------------------------------------------------------------- G_gallus_ENSGALP00000009257 ----------MEVLRRSSVFAAEVMEVFDRSPTDKELVSQAKALCRDYINSRLIR---AGVSWSKPE-HNT------------------------------------------------- G_gorilla_ENSGGOP00000010113 -----------------MDGSGEQ-PRGGGPTSSEQIMKTGALLLXXXXXXXXXX---XXXXXXXXXXXX-------------------------------------------------- A_aegypti_AAEL001515-PA ---------SPTLANNFANVWTNRRSPIHHLTTTQDVINQGKCLCGEYIRARLRR---SGLLNRKIL-QRLRSTME-------------------------------------------- D_rerio_ENSDARP00000040899 -----------------------------MACEASQDDQIGEALLIGVVRQELME---VMEVTEGNA-APPALPEAKP-----ISN---------------------------------- G_gallus_ENSGALP00000010509 --------------------------------METAEFYYVYYLAQDYLQYVLQE----------------------------------------------------------------- C_intestinalis_ENSCINP00000000654 ------------------------------------MVQQTRRVVEDYVLFRIHE---TIASESYDS-FSSRCKLEDQ-----ASRGF-------------------------------- A_carolinensis_ENSACAP00000008571 ----------------------------------DHLRKTTLEVVGRYLREAADE---AGSKGTGPN----------------------------------------------------- M_musculus_ENSMUSP00000044048 VLPLLERVSEAAKSSGADGSLPSTPPPPEEEE--DDLYRQSLEIISRYLREQA-----TGSKDSKPL----------------------------------------------------- T_rubripes_ENSTRUP00000030263 ----------MEMLRRSSVFAA---EVFDRSPTDKELVSQAKALCRDYIHSRLNR---AGVGWSKAD-HGL------------------------------------------------- T_rubripes_ENSTRUP00000001847 MNSVNGL------------DVSGRPAEDE-----AALDNDTRQLLSCFMADFCGI----------------------------------------------------------------- M_domestica_ENSMODP00000026730 --------------------------------MASPVSTDVPALAADFVHYKLKQ---KTYDNLLGL-EENF------------------------------------------------ 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000086454 NGATGHSSSLD---------------AREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHIT-------PGTAYQSFEQVV--N------E----LF-------------------- C_familiaris_ENSCAFP00000010478 NGATGHSSSLD---------------AREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHIT-------PGTAYQSFEQVV--N------E----LF-------------------- H_sapiens_ENSP00000365230 NGATGHSSSLD---------------AREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHIT-------PGTAYQSFEQVV--N------E----LF-------------------- P_pygmaeus_ENSPPYP00000012163 NGATGHSSSLD---------------AREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHIT-------PGTAYQSFEQVV--N------E----LF-------------------- P_troglodytes_ENSPTRP00000022903 NGATGHSSSLD---------------AREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHIT-------PGTAYQSFEQVV--N------E----LF-------------------- M_mulatta_ENSMMUP00000007865 NGATGHSSSLD---------------AREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHIT-------PGTAYQSFEQVV--N------E----LF-------------------- E_caballus_ENSECAP00000014770 NGATGHSSSLD---------------AREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHIT-------PGTAYQSFEQVV--N------E----LF-------------------- B_taurus_ENSBTAP00000008572 NGATGHSRSSD---------------AREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHIT-------PGTAYQSFEQVV--N------E----LF-------------------- O_cuniculus_ENSOCUP00000002775 NGATGHSSSLD---------------AREVIPMTAVKQALREAGDEFELRYRRAFSDLTSQLHIT-------PGTAYQSFEQVV--N------E----LF-------------------- R_norvegicus_ENSRNOP00000040259 NGATGHSSSLD---------------AREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHIT-------PGTAYQSFEQVV--N------E----LF-------------------- M_domestica_ENSMODP00000024313 SGATGHSSSLD---------------AHETIPVAAVKQALREAGDEFELRYRRAFSDLTSQLHIT-------PGTAYQSFEQVV--N------E----LF-------------------- G_gallus_ENSGALP00000010059 NGATVHRSSLE---------------VHEIVRASDVRQALRDAGDEFELRYRRAFSDLTSQLHIT-------PGTAYQSFEQVV--N------E----LF-------------------- T_guttata_ENSTGUP00000006866 NGATVHQNSLE---------------VHEIRRAADVRQALREAGDEFELRYRRAFSDLTSQLHIT-------PSTAYQSFEQVV--N------E----LF-------------------- A_carolinensis_ENSACAP00000011187 NGASEHPELLEE--------------EEEENPRVDVSQTLREAGDEFELRYRRAFSDLTSQLHIT-------LGTAYQSFEQVV--N------E----LF-------------------- R_norvegicus_ENSRNOP00000024954 NGATGHSSSLE---------------AREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHIT-------PGTAYQSFEQ-------------------------------------- D_rerio_ENSDARP00000095258 SPQRQ---------------------TNGSGGLDAVKEALRDSANEFELRYSRAFNDLSSQLHIT-------PATAYQSFESVM--D------E----VF-------------------- T_rubripes_ENSTRUP00000014135 --------------------------TSLATSLDTVKEALRDTGNEFELRYTCAFSDLHNQLHIT-------PATAYQSFENVM--D------E----VF-------------------- G_aculeatus_ENSGACP00000005643 -LQQR---------------------SPSTASLDAVKEALRDSANEFELRYARAFSDLHNQLHIT-------PATAYQSFEDVM--D------E----VF-------------------- T_nigroviridis_ENSTNIP00000007577 -PSQH---------------------QQSLTSLDAVKEALRDTGNEFELRYTCAFSDLHNQLHIT-------PATAYQSFENVM--D------E----VF-------------------- T_rubripes_ENSTRUP00000032199 --------------------------PSAGAGIEAVNAALRDSAEEFEKLFAQAFSDLSSQLDIT-------PDTAYQSFKNVM--D------E----VF-------------------- T_nigroviridis_ENSTNIP00000010122 --------------------------ASTGAGVEAVHAALRDSAEEFEKLFAQAFSDLSSQLVIT-------PDTAYQSFKNVM--D------E----VF-------------------- G_gallus_ENSGALP00000020984 ------SHHRPEPPG-SAAASEVPPAEGLRPAPPGVHLALRQAGDEFSRRYQRDFAQMSGQLHLT-------PFTAHGRFVAVV--E------E----LF-------------------- A_carolinensis_ENSACAP00000017311 ------ASLSPELLN-SDPVSTNAPREEPDPVPQVVHTTLRQAGDEFSRRYRRDFAQMSGQLHLT-------PSTARSRFVAVV--E------E----LF-------------------- R_norvegicus_ENSRNOP00000003768 ----TAARTSPLRPL------VATAGPALSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLT-------PFTARGRFATVV--E------E----LF-------------------- T_guttata_ENSTGUP00000002093 ------VSPHPEPPG-SATASHTPPAEGLRPAPQAVHLVLRQAGDEFSRRYQRDFSQMSGQLHLT-------PFTARSRFVAVV--E------E----LF-------------------- M_musculus_ENSMUSP00000108371 ----MAARTSPLRPL------VATAGPALSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLT-------PFTARGRFATVV--E------E----LF-------------------- G_aculeatus_ENSGACP00000013488 --------------------------PPPSGDTEAVKAALQDSANEFELLFTQAFSDLSLQLDVT-------PDTAYHSFKSVM--D------E----VF-------------------- M_mulatta_ENSMMUP00000008651 ----PVARTSPLPTP-AAPAAAAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLT-------PFTARGRFATVV--E------E----LF-------------------- O_latipes_ENSORLP00000017513 --------------------------CPCCASMDAIKSTLKDSADEFERRFHQGFSDLSVQLHIT-------PDTAYQNFKRVL--D------E----LF-------------------- H_sapiens_ENSP00000381185 ----PVARTSPLQTP-AAP--GAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLT-------PFTARGRFATVV--E------E----LF-------------------- P_troglodytes_ENSPTRP00000017121 ----PVARTSPLQTP-AAP--GAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLT-------PFTARGRFATVV--E------E----LF-------------------- E_caballus_ENSECAP00000017850 ------ARTSPLLPP-AAP--AGAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLT-------PFTARGRFATVV--E------E----LF-------------------- P_pygmaeus_ENSPPYP00000010339 ----P-ARTSPLPTP-AAP--GAAVGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLT-------PFTARGRFATVV--E------E----LF-------------------- G_gorilla_ENSGGOP00000000778 ----RVARTSPLQTP-AAP--GAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLT-------PFTARGRFATVV--E------E----LF-------------------- X_tropicalis_ENSXETP00000053903 --------------------------ATQGIVGEEVLQALLDASEEFELRYQRAFSDLTAQLHLT-------QDTAQQSFQQVV--G------E----LF-------------------- M_domestica_ENSMODP00000006458 TSTTAAARNSPLPLPPPAVAAAAAAGPTVSPVPPVVHLTLRQAGDDFSRRYRRDFDEMSGQLHLT-------PVTARGRFATVV--E------E----LF-------------------- C_familiaris_ENSCAFP00000000102 -------------------------SASXSPVPPVVHLTLRQAGDDFSRRYRR-FAEMSSQLHLT-------PFTARGRFATVV--E------E----LF-------------------- D_rerio_ENSDARP00000096467 IAR-----------------------VTRSDPHLRLYRVLRDAGDEIERIYQREFEEMSQQMVFN-------PNSAQRSFLTVA--E------E----LF-------------------- X_tropicalis_ENSXETP00000052058 ------SRGPPQSSLASAAASSDEETPTMQPVPPAVLQTLSRAGDEFSRLYQQDFRQISGLLHLT-------PSTVRVRFATVV--E------E----LF-------------------- B_taurus_ENSBTAP00000025701 -----PSRTSPPPPP------AAAAGPAPSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLT-------PFTARGRFATVV--E------E----LF-------------------- X_tropicalis_ENSXETP00000031936 --------------------------EPAGAASCSLHSAMRAAGDEFEERFRQAFSEISTQIHVT-------PGTAYARFAEVA--G------S----LF-------------------- O_latipes_ENSORLP00000021005 --------------------------PTPADPLADIHRVLREAGDELERLYQRDFTEMSRQLYLT-------STTAKTRFAEVI--D------E----LF-------------------- O_anatinus_ENSOANP00000014671 --------------------------------AQPLHRAMRAAGDEFESRFRRAFSDLASQLHVT-------PGSAQQRFTQVS--D------E----LF-------------------- M_musculus_ENSMUSP00000022806 --------------------------PGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVT-------PGSAQQRFTQVS--D------E----LF-------------------- H_sapiens_ENSP00000250405 --------------------------PGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVT-------PGSAQQRFTQVS--D------E----LF-------------------- B_taurus_ENSBTAP00000026248 --------------------------PGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVT-------PGSAQQRFTQVS--D------E----LF-------------------- E_caballus_ENSECAP00000008404 --------------------------PGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVT-------PGSAQQRFTQVS--D------E----LF-------------------- P_troglodytes_ENSPTRP00000010457 --------------------------PGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVT-------PGSAQQRFTQVS--D------E----LF-------------------- M_domestica_ENSMODP00000005598 --------------------------PGEGPTTEPLHRAMRAAGDEFESRFRRTFSDLAAQLHVT-------PGSAQQRFTQVS--D------E----LF-------------------- G_gorilla_ENSGGOP00000001415 --------------------------PGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVT-------PGSAQQRFTQVS--D------E----LF-------------------- T_rubripes_ENSTRUP00000012873 SHPCKE--------------------PPASDQHAAIHRVLREAGDELERLYQPDFTEMSRQLYLS-------STTAQRRFAEVI--D------E----LF-------------------- M_mulatta_ENSMMUP00000019355 --------------------------PGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVT-------PGSAQQRFTQVS--D------E----LF-------------------- G_aculeatus_ENSGACP00000017662 PRLCKRL-------------------PQSDPTAAATHRVLREAGDELERLYQPDFTEMSRQLYLT-------STTAQRRFAEVI--D------E----LF-------------------- T_nigroviridis_ENSTNIP00000002788 PHLCKR--------------------TPQSEQHAAIHRVLREAGDELERLYQPDFTEMSRQLYLT-------STTAQRRFAEVI--D------E----LF-------------------- R_norvegicus_ENSRNOP00000056470 --------------------------PGKGPAADLLHQAMHAAGDEFETRFRYTFSDLATQQHVT-------PGSAQQRFTQVS--D------E----LF-------------------- T_nigroviridis_ENSTNIP00000013781 --------------------------PSSDAGRRAVKAVLRKATDDFEKKLTRACGDLSSYLP---------SKISHQNFNNTM--D------Q----IF-------------------- T_rubripes_ENSTRUP00000036532 --------------------------PSAGTGREAVIAALRSMANKFEQDFIQLAGDLSSYGAVT---------RNQASFNKLM--D------N----MF-------------------- M_domestica_ENSMODP00000037249 --------------------------PGESSALIPLWQAMQRAGDESESLVQGTFPHLTTQFHLS-------PETAQHYFTQVS--D------E----LF-------------------- T_rubripes_ENSTRUP00000012299 --------------------------PSAGTGREAVIAALRSMANKFEQDFIQLAGDLSSYVAMT---------RNQACFNKVM--D------D----MF-------------------- T_rubripes_ENSTRUP00000033198 --------------------------PSAGTGREAVNAALRSMANKFEQ-FIQLAGD-SAYVAMT---------RNQESFNKVM--D------D----MF-------------------- T_rubripes_ENSTRUP00000005426 --------------------------PPAGTGREALNAALRSMANKYERDFMEQAGDLSPYVAVT---------RNKAGFNKVM--D------D----MF-------------------- A_carolinensis_ENSACAP00000016202 --------------------------HEPNSTNCQVGRRLATIGDDINARYDKEFSEMLKSLQPT-------KDNAYEYFIRIA--S------S----LF-------------------- X_tropicalis_ENSXETP00000056677 ------------------------------XNLISVGQQLAKIGDDINERYQEQFDDILKHLNPS-------LDNAYSYFKKIA--S------S----LF-------------------- M_musculus_ENSMUSP00000077757 --------------------------LEPNSILGQVGRQLALIGDDINRRYDTEFQNLLEQLQPT-------AGNAYELFTKIA--S------S----LF-------------------- M_domestica_ENSMODP00000017616 --------------------------QELSSTTEQVGRQLAVIGDDISRRYDSEFKAMLQHLQPT-------PDTAYEYFTKIA--SRISAPHS----LF-------------------- R_norvegicus_ENSRNOP00000000576 --------------------------LEPNSVLGQVGRQLALIGDDINRRYDTEFQNLLEQLQPT-------AGNAYELFTKIA--S------S----LF-------------------- X_tropicalis_ENSXETP00000050759 --------------------------QHSDPSIKRLSECLRKIGDELDA--NIELQRRIECVP---------CNSPKQVFFHVA--K------E----LF-------------------- E_caballus_ENSECAP00000021385 --------------------------LEPNSTMGQVGRQLAIIGDDINRRYDSEFQTMLKHLQPT-------AENAYELFTKIA--S------S----LF-------------------- B_taurus_ENSBTAP00000000549 --------------------------PEPSSTMGQVGRQLAVIGDDINRRYDAEFQAMLQHLQPT-------ADNAYEYFTKIA--S------S----LF-------------------- A_carolinensis_ENSACAP00000017228 -----------------------------DPKTKQLSECLRRIGDELDG--NMELQSMIEQVQ---------VYPPKEVFFRVA--A------E----MF-------------------- A_aegypti_AAEL001521-PA --------------------------TPTIHVVREVFPALLSVGEELERMYPRVYNGVARQLSRIGRGELKTPETAPVLLSAIA--R------D----LF-------------------- O_latipes_ENSORLP00000005745 --------------------------ELVDPNHKRLAQCLQQIGDELDG--NVELKRLIDDSS---------LSPSKEVFLKVA--L------E----IF-------------------- D_rerio_ENSDARP00000023687 --------------------------ELCDPSHKRLAQCLQQIGDELDG--NAQLQSMLNNSN---------LQPTQDVFIRVA--R------E----IF-------------------- G_gallus_ENSGALP00000039057 --------------------------QELGSTGSQVGRRLAIIGDDINKRYDAEFRHMLKSLQPT-------KENAYEYFTTIA--S------S----LF-------------------- T_rubripes_ENSTRUP00000036334 ----------------------------SDPNHKKLAQCLQKIGDELDG--NMELQRMINDSA---------LKPTKDMFMKVA--L------E----IF-------------------- O_cuniculus_ENSOCUP00000002204 --------------------------LEPNSTMGQVGRQLAIIGDDINQRYDSDFQNMLEKLQPT-------AENAYELFTKIALSS------D----LF-------------------- G_aculeatus_ENSGACP00000018700 --------------------------ELSDPNHKKLAMCLQQIGDELDG--NVELQRMMNDSS---------LGPTKDVFLKVA--F------E----IF-------------------- H_sapiens_ENSP00000363591 --------------------------LQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPT-------AENAYEYFTKIA--T------S----LF-------------------- G_gorilla_ENSGGOP00000015828 --------------------------LQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPT-------AENAYEYFTKIA--T------S----LF-------------------- P_troglodytes_ENSPTRP00000050271 --------------------------LQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPT-------AENAYEYFTKIA--T------S----LF-------------------- D_melanogaster_FBpp0087182 --------------------------STSMGIVRDVFPAVQVLGDELERMHPRIYNGVARQICRNPGGEFHTPDAVSLLLGAVG--R------E----LF-------------------- A_carolinensis_ENSACAP00000004550 --------------------------SPDAAAVTSLQDCMFRIWQELSS--NRDLTSMVESAT---------GKNPLEVLADVS--E------H----LF-------------------- G_aculeatus_ENSGACP00000006084 --------------------------AAPGGGLGDVSSALLWLGDELEYLRPNVYRNVARQLNIT----VASESIVSDAFLAVA--A------D----IF-------------------- C_familiaris_ENSCAFP00000001449 --------------------------LEPSSTMGQVGRQLAIIGDDINQRYDSEFQAMLQHLQPT-------AENAYEYFTKIA--S------RCHLFLF-------------------- D_rerio_ENSDARP00000037180 ----------------------------QQTPPSESAEAMRYLAKEMEQQHRTKFRSLSQEFLDT------CGADPSKCLQSVM--R------E----LV-------------------- R_norvegicus_ENSRNOP00000028328 --------------------------PPQDASTKKLSECLRRIGDELDN--NMELQRMIADVD---------TDSPREVFFRVA--A------D----MF-------------------- M_domestica_ENSMODP00000017160 --------------------------LPSDPRTKRLTECLRRIGDELDS--NMELQRMIAAVE---------TDSPREVFFRVA--A------E----MF-------------------- M_musculus_ENSMUSP00000033093 --------------------------PPQDASTKKLSECLRRIGDELDS--NMELQRMIADVD---------TDSPREVFFRVA--A------D----MF-------------------- M_mulatta_ENSMMUP00000011943 --------------------------LQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPT-------AENAYEYFTKIA--S------SS--VLF-------------------- P_pygmaeus_ENSPPYP00000006150 --------------------------LQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPT-------AENTCEYFTKIA--S------S----LF-------------------- T_nigroviridis_ENSTNIP00000005841 --------------------------PASGGTLGEASAVLLWLGDELEHLRPNVYCNVARQLNIT----VASESIMSDAFLAVA--A------D----IF-------------------- B_taurus_ENSBTAP00000017739 --------------------------VPQDASTKKLSECLKRIGDELDS--NMELQRMIAAVD---------TDSPREVFFRVA--A------E----MF-------------------- G_aculeatus_ENSGACP00000018053 --------------------------SPSSAALAEVSLVLLCLGDELESIRPSLYRNVARQLNIS----VAMENMVSDAFIGVA--T------E----IF-------------------- A_gambiae_AGAP011552-PA --------------------------LGGGAVVREALPILNGMGEELERMHPRLYSNVSRQISNEPWGELTEPDTVGYLLHVVA--K------D----LF-------------------- H_sapiens_ENSP00000314132 --------------------------PVP-GRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHIS----LQSEPVVTDAFLAVA--G------H----IF-------------------- G_gorilla_ENSGGOP00000015296 --------------------------PVP-GRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHIS----LQSEPVVTDAFLAVA--G------H----IF-------------------- M_mulatta_ENSMMUP00000007481 --------------------------PVP-GRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHIS----LQSEPVVTDAFLAVA--G------H----IF-------------------- P_pygmaeus_ENSPPYP00000014939 --------------------------PVP-GRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHIS----LQSEPVVTDAFLAVA--G------H----IF-------------------- M_domestica_ENSMODP00000020066 --------------------------PTPGGKLAEVASILLRLGDELEYIRPNVYRNIARQLNIS----LQSESVVTDAFLAVA--T------Q----IF-------------------- P_troglodytes_ENSPTRP00000019323 --------------------------VPQDASTKKLSECLKRIGDELDS--NMELQRMIAAVD---------TDSPREVFFRVA--A------D----MF-------------------- A_carolinensis_ENSACAP00000000851 --------------------------PVPGGKLAEVSNILLRLGDELEYIRPNLYRNVARQLNIS----LHSETVVTDAFLAVA--T------Q----IF-------------------- M_mulatta_ENSMMUP00000005209 --------------------------VPQDASTKRLSECLKRIGDELDS--NMELQRMIAAVD---------TDSPREVFFRVA--A------D----MF-------------------- O_anatinus_ENSOANP00000008963 --------------------------PSPGGKLAEVSTILLRLGDELEYIRPNVYRNIARQLNIS----LHSETVVTDAFLAVA--T------Q----IF-------------------- D_rerio_ENSDARP00000068408 ----------------------------SGGTLAEVSSVLLWLGDELEYLRPNVYRNVARQLNIT----IASENIVSDAFLAVA--A------E----IF-------------------- T_nigroviridis_ENSTNIP00000017211 --------------------------EQRDPQTKEVVEQLLKIADDLNR--NAEFQHLVSQVQ---------GNCAQDVFMQVA--R------S----IF-------------------- M_musculus_ENSMUSP00000027499 --------------------------PAPGGRLAEVCTVLLRLGDELEQIRPSVYRNVARQLHIP----LQSEPVVTDAFLAVA--G------H----IF-------------------- R_norvegicus_ENSRNOP00000024693 --------------------------PAPGGRLAEVCTVLLRLGDELEQIRPSVYRNVARQLHIP----LQSEPVVTDAFLAVA--G------H----IF-------------------- G_aculeatus_ENSGACP00000018978 --------------------------EHQDPQIKEVVKQLMKIADEMNR--NAELQRLISQVP---------GNCAQDIFMKVA--K------S----IF-------------------- H_sapiens_ENSP00000293288 --------------------------VPQDASTKKLSECLKRIGDELDS--NMELQRMIAAVD---------TDSPREVFFRVA--A------D----MF-------------------- R_norvegicus_ENSRNOP00000052069 --------------------------PPQDASTKKLIECLRRIRDELDN--NMVLQRMVADVD---------TDSPREVFFRVA--A------D----MF-------------------- D_rerio_ENSDARP00000013345 --------------------------PHSKSGRKQVLSTMRRVVDNLAVKHELAYKGMIARLNLE------QKGEDVSFIKQVA--T------E----LF-------------------- T_guttata_ENSTGUP00000006267 --------------------------PVPGGKLAEVSTILLRLGDELEYIRPNVYRNIARQLNIS----LHSETVVSDAFLAVA--T------Q----IF-------------------- D_rerio_ENSDARP00000015664 --------------------------CPVDRKLHHAIPTMKRVVDNILVKHQIAYKGMIQRLQLD------SQPASLDFIRCIA--S------T----MF-------------------- O_cuniculus_ENSOCUP00000005553 --------------------------GPQDESTKKLSECLKRIGDELDS--NMELQRMIAAVD---------TDSPREVFFRVA--A------D----MF-------------------- B_taurus_ENSBTAP00000000977 --------------------------QQPGSKPSKTSRVLQDVASSVQDEVERTLKQCLDKFDVV------SVDTARTIFNQVM--E------K----EF-------------------- T_nigroviridis_ENSTNIP00000018321 --------------------------SPSSTALADASMVLLCLGDELESMQPSLYRNVARQLNIS----VAMENMVSDAFIAVA--T------E----IL-------------------- B_taurus_ENSBTAP00000011478 --------------------------PVPGGRLAEVCAVLLRLADELELIRPSVYRNVARQLNLS----LQSETVVTDAFLAVA--T------Q----IF-------------------- D_melanogaster_FBpp0085443 --------------------------PGSSHVVYEVFPALNSMGEELERMHPRVYTNISRQLSRAPFGELEDSDMAPMLLNLVA--K------D----LF-------------------- T_guttata_ENSTGUP00000008329 --------------------------SHLGPAQTRVAHVLRTMASSLQDQTEEAVRPLLDRIDIT------SVAAAKRIFNGVM--D------E----KF-------------------- G_gallus_ENSGALP00000009257 --------------------------PVPGGKLAEVSAILLCLGDELEYIRPNVYRNIARQLNIS----LHSETVVTDAFLAVA--A------Q----IF-------------------- G_gorilla_ENSGGOP00000010113 --------------------------XXXXXSTKKLSECLKRIGDELDS--NMELQRMIAAVD---------TDSPREVFFRVA--X------D----MF-------------------- A_aegypti_AAEL001515-PA --------------------------VPNCVVVRETSPILNGMGEELERMHPRLYTNVSRQISVEPWGELTEPDSVCYLLHIVA--K------D----LF-------------------- D_rerio_ENSDARP00000040899 --------------------------SQDQILVQQLANTIKVIGDKLDQ--DQAFNDMIDGLV---------KVADKSSFWKLV--E------K----VF-------------------- G_gallus_ENSGALP00000010509 --------------------------SHLGPAQTRVAHVLRNIASSLQDQTEEALRPFLDRIDIT------SVDVAKRIFNGVM--E------E----KF-------------------- C_intestinalis_ENSCINP00000000654 --------------------------PLPQTNPARLNVSIRKIAAEYERRYRETFPDLLEEIKTV----NMSTDDVDKTFSRIC--K------D----LFQLPLKRNYPDNAMKSQATSN A_carolinensis_ENSACAP00000008571 --------------------------SPNEAEVARALETLRRVGESLREKHLLAFQGMLRKLEIK-------KEEDLASVAEVT--T------E----VF-------------------- M_musculus_ENSMUSP00000044048 --------------------------GEAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIK-------NEGDVKSFSRVM--V------H----VF-------------------- T_rubripes_ENSTRUP00000030263 --------------------------AASGGTLGEVSSVLMWLGAELEYLRPNVYCNVARQLNIT----VASESIMSDAFLAVA--A------D----IF-------------------- T_rubripes_ENSTRUP00000001847 --------------------------GSHQWRESGALSTMKRVVANLMEKHRYVYNGMTKQLTLD------DRGDDVSFVSSVA--K------S----IF-------------------- M_domestica_ENSMODP00000026730 --------------------------FAGVPSREPLHLAMHSSGDQYEFFCNNTTIDL---------------DHAMKYFNHAA--D------E----IF-------------------- 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000086454 ------------R