10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000091238 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000014096 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000017020 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000015808 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000311032 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000019797 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000032189 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000021099 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005556 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000040783 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005560 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006879 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000517 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000017288 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003217 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000009934 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010095 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000040691 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000071815 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022402 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000006831 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000011206 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010793 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000014503 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000022078 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000019984 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000031759 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008661 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026062 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000022693 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000001627 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000016420 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000009498 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000005216 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000008706 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000358327 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000003106 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013731 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005512 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002508 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000005723 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000007184 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000014729 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000033547 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011493 -------------------------------------------------------------------------------------MDPHPADFPEPPPQPRITLRSDTVDSSVFHDDDNL O_anatinus_ENSOANP00000005811 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013268 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000012376 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004278 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP000830-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0084848 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000016744 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000029626 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000265164 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000016642 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000003204 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000007353 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000028104 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023055 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000022652 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000052017 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000016791 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003444-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000050929 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012644 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000021186 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004920-PA ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000013049 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000019870 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL014348-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000072390 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0071971 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000041413 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009832-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011952-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000093958 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011951-PA ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000005993 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011835 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000010625 ------------------------------------------------------------DFRKLLFEVSEALVTEELSALKFLSLDHVPRRKLEAIHEPKAFFEVLQEKDMIGAGNLFF A_gambiae_AGAP004921-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000017449 --------------------------------------------------------------------------------------------------------MEERQRRALRRGRARL C_intestinalis_ENSCINP00000025743 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000013591 -----------------------------------------------------------MEFSQLLFVISEALDRTELASLKFLSLEHVTVRKREDIEEPKAFFQALQEKGMIEVGDLFF O_anatinus_ENSOANP00000006351 -----------------------------------------------------------MDFHRLLFSIGEELAADDLEALKFLCLDLIPRKKQENIQDALGLFRLLQEKGMLEEGKLFF B_taurus_ENSBTAP00000003205 --------------------------------------------------------------------------------------------------------MNEADRLLLRRYRVRL B_taurus_ENSBTAP00000038128 -----------------------------------------------------------MALTQCLYNIGEQLGSDDLAALKFLSRDHIPYRKQEPIKDALMLFQRLQEKRMLEENNLSF R_norvegicus_ENSRNOP00000017972 --------------------------------------------------------------------------------------------------------MEEADRQLLRRCRVRL G_gallus_ENSGALP00000013506 -----------------------------------------LKSFKPHWISSNMEDDDSLQFRQLLLLIDEGLGAEDVAALKFLCTDLIPFRKLESVQSAMDIFQLLIDEDYLNEEDTFL E_caballus_ENSECAP00000015102 --------------------------------------------------------------------------------------------------------MNEADRQLLRRSRLRL T_nigroviridis_ENSTNIP00000013855 --------------------------------------------------------------------------------------------------------MEERHKKILQRNRINL M_musculus_ENSMUSP00000030747 --------------------------------------------------------------------------------------------------------MDEADRQLLRRCRVRL O_anatinus_ENSOANP00000015596 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000002138 --------------------------------------------------------------------------------------------------------MDEADRRLLWRCRLRL C_familiaris_ENSCAFP00000023986 --------------------------------------------------------------------------------------------------------MDEAERRALRRCRVRL M_mulatta_ENSMMUP00000037892 VEGGRRARVVTESKRNFFLGACPTPFPTEHVELGRLGGSETAMVPGKGGADYILLPFEEMDFNRNLYDIGEQLDSEELASLKFLSLDCIPQRKQEPIKDALMLFQRLQEKRMLEENNLSF D_melanogaster_FBpp0082755 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000047019 --------------------------------------------------------------------------------------------------------MEQKHRQILQRHRLNL O_cuniculus_ENSOCUP00000006164 -------------------------------ALVESGTVGDWVTVPGEGNGYXXXXXXXXXXXXXXXXXXEQLDSELL--LKF-ELDYIPQRKQEPIQDALMLFQRLQEKRMLEENNLAF P_pygmaeus_ENSPPYP00000014606 -----------------------------------------------------------MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF C_familiaris_ENSCAFP00000017899 -----------------------------------------------------------MDFSKCLYNIGEQLDSDELASLKFLSLDYIPQKKQEPIKDPLMLFQRLQEKRMLEESNLFF H_sapiens_ENSP00000351273 MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF P_troglodytes_ENSPTRP00000021879 MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF A_aegypti_AAEL012143-PA ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000016613 -----------------------------------------------------------MDFHSCLYDIAERLGNEELAALKFLCLDHIPQKKQESINDVLVLFQRLQEEGMLEEDNLSF M_musculus_ENSMUSP00000027189 -----------------------------------------------------------MDFQSCLYAIAEELGSEDLAALKFLCLDYIPHKKQETIEDAQKLFLRLREKGMLEEGNLSF P_troglodytes_ENSPTRP00000056642 ---------------------------------------------------------------------RGGRPWGGGGSWGLGRAAEARKRTEAAWSLSWLLAMDEADRRLLRRCRLRL E_caballus_ENSECAP00000004055 -----------------------------------------------------------MNFNSCLYNIGEQLDSDELASLKFLSLDHIPQRKQEPIQDALMLFQRLQEKRLLEESNLSF H_sapiens_ENSP00000365051 ---------------------------------------------------------------------RGGRPWGGGGSWGLGRAAEARKRTEAAWSLSWLLAMDEADRRLLRRCRLRL T_nigroviridis_ENSTNIP00000001216 --------------------------------------------------------------------------------------------------SAYQLFLSLCDQDHLSEERPHL M_mulatta_ENSMMUP00000040583 --------------------------------------------------------------------------------------------------------MDEADRRLLRRCRLRL G_aculeatus_ENSGACP00000007379 --------------------------------------------------------------------------------------------------------MEEIHKRILQRNRINL G_gorilla_ENSGGOP00000000205 ---------------------------------------------------YILLPFEKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF M_domestica_ENSMODP00000004412 --------------------------------------------------------------------------------------------------------MEESQRELFQKNRLRL G_gallus_ENSGALP00000002083 --------------------------------------------------------------------------------------------------------MEEAQRSALRRGRVRL G_aculeatus_ENSGACP00000005791 -----------------------------------------------------------MHFQKLLFDIGKALSGEEVKALAFLCTDILG-RNLSSVESASGLFSRLRDQGFLSAEQPHL T_rubripes_ENSTRUP00000045375 --------------------------------------------------------------------------------------------------------MEERHKKILQRNRTNL M_domestica_ENSMODP00000036247 -----------------------------------------------------------MDFHTFLYGIAEEIDSADLASLKFLCLDQIPLKKQQHIKDALVLFQTLEERGLLEEDNLFF D_rerio_ENSDARP00000024255 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011503 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000024485 ------------------------------------------------------------EFRLLLHQICEGLTGENVSMMKFLCKDAIPRSR--ELETALDFMEYFEAKGWIQEGDLGF T_rubripes_ENSTRUP00000044662 ---------------------------------------------------------CNMDFQARLLKVGNDLRKDEVRALVFLCSDILGCNP-AAVQSAGDLFSRLSDQDHLSEEQPHL E_caballus_ENSECAP00000021726 ------------------------------------------MTSQGQNLNSSSDDNCTMDFRQKLLFIDSHLGDQDVERLRFLCRDCVSHKKLEKSSSALEIFNHLLAEDLLREEDSFF A_aegypti_AAEL003439-PA ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013740 ------------------------------------------------------------------------------------------------------CGMQERDRLALRTRSTVL C_intestinalis_ENSCINP00000025905 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000001932 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000003895 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011950-PA ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000028692 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000075645 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000015114 ------------------------------------------------------------------------------------------------RSVTQKCGMQKRDAEALRNCSVCL O_latipes_ENSORLP00000003208 --------------------------------------------------------------------------------------------------------MEEKHKRILRRNRVHL X_tropicalis_ENSXETP00000008971 -----------------------------------------------------------MDFNSMLLSIDDGLGREDIEALKFLCRDVLRKNKLLSVRSGQELFQQLMTEDLINEDNFFL A_gambiae_AGAP011949-PA ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000005531 ------------------------------------------------------------------------------------------------------------------------ C_elegans_C48D1.2 -------------------------------------------------------------------------------------------------------MMRQDRRSLLERNIMMF H_sapiens_ENSP00000286186 ------------------------------------------MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFF A_gambiae_AGAP012544-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000017933 ------------------------------------------MTSQAQSLTFRSDDNCQSSFRGKLLTIDSKLEIQDVEGLKFLCRDFVSHKKLEKSNSASDIFDHLLAEELLSEEDPFF A_gambiae_AGAP004922-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000075318 --------------------------------------------------------------------------------------------------------MADQLLENLRPDLIKG G_gallus_ENSGALP00000013571 ---------------------------------------------------------MSSDFRKLLFDISEALATEELAALKFLSLEHVPVRKQEDTEEPKAFFEVLKEKGMIEVEDLFF 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000091238 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000014096 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000017020 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000015808 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000311032 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000019797 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000032189 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000021099 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005556 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000040783 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005560 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006879 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000517 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000017288 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003217 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000009934 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010095 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000040691 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000071815 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022402 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000006831 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000011206 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010793 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000014503 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000022078 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000019984 -----------------------------------------------------------------------------------------------------MDKEALTSENEVSGDDQEN T_rubripes_ENSTRUP00000031759 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008661 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026062 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000022693 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000001627 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000016420 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000009498 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000005216 -------------------------------------------------------------------------------------------------------------MDCVGWPPGRK B_taurus_ENSBTAP00000008706 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000358327 -------------------------------------------------------------------------------------------------------------MDCVGWPPGRK P_pygmaeus_ENSPPYP00000003106 -------------------------------------------------------------------------------------------------------------MDCVGWPPGRR E_caballus_ENSECAP00000013731 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005512 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002508 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000005723 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000007184 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000014729 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000033547 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011493 FSMDDAVEQPDSFDAVPPNSYPSPN------------------------------------------------------------------------------------SSLSTSYSGGD O_anatinus_ENSOANP00000005811 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013268 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000012376 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004278 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP000830-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0084848 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000016744 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000029626 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000265164 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000016642 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000003204 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000007353 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000028104 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023055 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000022652 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000052017 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000016791 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003444-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000050929 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012644 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000021186 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004920-PA ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000013049 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000019870 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL014348-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000072390 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0071971 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000041413 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009832-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011952-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000093958 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011951-PA ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000005993 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011835 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000010625 LKELLYRIHRIDLLSTPLGCSREEMERELQLPGRAQVSAY--------------------------------R------------------------------------QLLYGIAEDLT A_gambiae_AGAP004921-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000017449 VAALRVEPLWEPLEQRG--------------------------------------------------------------------------------------------LFTRPMLEELQ C_intestinalis_ENSCINP00000025743 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000013591 LKELLYRINRIDLLASYLGSSREEMERELQVPGRARVSPF--------------------------------R------------------------------------YLLFQLSENIT O_anatinus_ENSOANP00000006351 LKELLFRIHRIDLLTSHLRTSQEDVARELEEPGRAQVSAY-------------------------------SR------------------------------------VLLFTLSDNVT B_taurus_ENSBTAP00000003205 VGELQVASLWDALLSRE--------------------------------------------------------------------------------------------LFTPDMIEDIQ B_taurus_ENSBTAP00000038128 LKELLFRVNRLDLLLNYLYTSEEEMKRELQIPGRAQISAY--------------------------------R------------------------------------ILLFQISEDVN R_norvegicus_ENSRNOP00000017972 VRELQVAELWDALLSRE--------------------------------------------------------------------------------------------LFTRDMIEDIQ G_gallus_ENSGALP00000013506 LAELLYRIKYHSLLSKLGYTKEK---VQECLHEKGKVSPY--------------------------------R------------------------------------QMLYELSENIT E_caballus_ENSECAP00000015102 VRELQVDSLWDALLTRE--------------------------------------------------------------------------------------------LFTPDMIEDIQ T_nigroviridis_ENSTNIP00000013855 VSELEPLNLYDGLIEKG--------------------------------------------------------------------------------------------VFTHDMIDEIK M_musculus_ENSMUSP00000030747 VSELQVAELWDALLSRE--------------------------------------------------------------------------------------------LFTRDMIEDIQ O_anatinus_ENSOANP00000015596 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000002138 VEELQVDQLWDALLSRE--------------------------------------------------------------------------------------------LFRPHMIEDIQ C_familiaris_ENSCAFP00000023986 VRELQVAALWDALLSRE--------------------------------------------------------------------------------------------LFTAAMVEDLQ M_mulatta_ENSMMUP00000037892 LKELLFRINRLDLLTTYLNTRKEEMERELQAPGRAQISAY--------------------------------R------------------------------------VMLYQISEEVG D_melanogaster_FBpp0082755 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000047019 VKALNPEDVCDKLLSKG--------------------------------------------------------------------------------------------VFTQDMIDEIQ O_cuniculus_ENSOCUP00000006164 LKELLFRIHRLDLLSTLLGTSKEEMVTELQIPGRAHISAY--------------------------------X------------------------------------XXXXXXXXXXX P_pygmaeus_ENSPPYP00000014606 LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQSVPFWWRVDHILIR------------------------------------VMLYQISEEVS C_familiaris_ENSCAFP00000017899 LKELLFRINRLDLLMTYLDTSKEDMQQELQIPGRAQISAY--------------------------------R------------------------------------VMLFQISEDVS H_sapiens_ENSP00000351273 LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY--------------------------------R------------------------------------VMLYQISEEVS P_troglodytes_ENSPTRP00000021879 LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY--------------------------------R------------------------------------VMLYQISEEVS A_aegypti_AAEL012143-PA ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000016613 LKELLFHISRRDLLSRVLKSSPEEMVRELQVLGKAQVSAY--------------------------------R------------------------------------VMLFKLSEDMD M_musculus_ENSMUSP00000027189 LKELLFHISRWDLLVNFLDCNREEMVRELRDPDNAQISPY--------------------------------R------------------------------------VMLFKLSEEVS P_troglodytes_ENSPTRP00000056642 VEELQVDQLWDALLSRE--------------------------------------------------------------------------------------------LFRPHMIEDIQ E_caballus_ENSECAP00000004055 LKELLFRINRLDLLTTELDTSKEEMERELQSPGRAQISAY--------------------------------R------------------------------------VMLFQISEDVN H_sapiens_ENSP00000365051 VEELQVDQLWDALLSRE--------------------------------------------------------------------------------------------LFRPHMIEDIQ T_nigroviridis_ENSTNIP00000001216 LSELLSIIQRTRLLRDLDLRSSA---------TSNLISAY--------------------------------R------------------------------------KLLYSLSEDLT M_mulatta_ENSMMUP00000040583 VEELQVDQLWDALLSRE--------------------------------------------------------------------------------------------LFKPHMIEDIQ G_aculeatus_ENSGACP00000007379 VRDLDPSSLYDGLLEKG--------------------------------------------------------------------------------------------VFTQDMIDEIK G_gorilla_ENSGGOP00000000205 LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY--------------------------------R------------------------------------VMLYQISEEVS M_domestica_ENSMODP00000004412 VCELQVEPLWDLMLDRE--------------------------------------------------------------------------------------------LFTRDMIEDIQ G_gallus_ENSGALP00000002083 VEGLRPEVLWGPLQARG--------------------------------------------------------------------------------------------VFTSAMVEDMQ G_aculeatus_ENSGACP00000005791 LTELLIIIQRVRLTRDVDLPAEP----------SSLISPY--------------------------------R------------------------------------KMLYNLSEELT T_rubripes_ENSTRUP00000045375 VGELDPSSLYDGLIEKR--------------------------------------------------------------------------------------------VFTHDMIDEIK M_domestica_ENSMODP00000036247 LKELLFRINRIDLLNEPLNTKGPEMERELQVPNKARISPY--------------------------------RLHLHTTIWPFRDNWTCRITLSVSFTSRTKQLLSVMVILLFNLSEGVG D_rerio_ENSDARP00000024255 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011503 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000024485 LAEVLYRINRHDLLKLLPGVKNRRDYEENFQAQQNNFTTY------------------------------------------------------------R--------VVCFMLADELT T_rubripes_ENSTRUP00000044662 LVELLGIIQRTKLLRDHNLPRTG---------AQDLISPY--------------------------------S----------------------CKSR----------KLLYSLSEELT E_caballus_ENSECAP00000021726 LAELLYIIKQKSLLCHLCYTKEQ---VESLLPARRRVSLF--------------------------------R------------------------------------NLLYELSEGMD A_aegypti_AAEL003439-PA ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013740 CKQLVVDELLIQSLQTDE-------------------------------------------------------------------------------------------ILTEAMAENIM C_intestinalis_ENSCINP00000025905 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000001932 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000003895 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011950-PA ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000028692 ----------------------------------------------------------------------------------------------------------------------MS D_rerio_ENSDARP00000075645 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000015114 LKDLVVDELLIQALVKDG-------------------------------------------------------------------------------------------ILTQNMAESIM O_latipes_ENSORLP00000003208 VKELDLSDLCDVLLRKD--------------------------------------------------------------------------------------------VFTQSMINDIK X_tropicalis_ENSXETP00000008971 LKELLYIINHHSLLRNLGTNKEK---VQKALPRQGRISPY-----------------------------------------------------------R---------QMLYQLSENIA A_gambiae_AGAP011949-PA ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000005531 ------------------------------------------------------------------------------------------------------------------------ C_elegans_C48D1.2 SSHLKVDEILEVLIAKQV-------------------------------------------------------------------------------------------LNSD---NGDM H_sapiens_ENSP00000286186 LAELLYIIRQKKLLQHLNCTKEE---VERLLPTRQRVSLF--------------------------------R------------------------------------NLLYELSEGID A_gambiae_AGAP012544-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000017933 LAELLYIIKQNSLLRYLNQSKEQ---VESLLPTRRRVSLF--------------------------------R------------------------------------NLLYELSESIG A_gambiae_AGAP004922-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000075318 LSERVINGLLDDLQQKK--------------------------------------------------------------------------------------------VFGEEEIEDIQ G_gallus_ENSGALP00000013571 LKELLYRINRIDLLASHLGSSREEMERELQVPGKAKVSAY--------------------------------R------------------------------------QLLYGIAEDLT 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000091238 ------------------------------------MENNKTSVDSKS------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000014096 ------------------------------------MDNNETSVDSKS------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000017020 ------------------------------------MENTENSVDSKS------------------------------------------------------------------------ M_mulatta_ENSMMUP00000015808 ------------------------------------MENTENSVDSKS------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000054330 ------------------------------------MENTENSVDSKS------------------------------------------------------------------------ H_sapiens_ENSP00000311032 ------------------------------------MENTENSVDSKS------------------------------------------------------------------------ E_caballus_ENSECAP00000019797 ------------------------------------MENSKISVDSKS------------------------------------------------------------------------ C_familiaris_ENSCAFP00000032189 --------MGEQRNTSSKELAAAEATGQSGKELEVSMENTENSVDAKS------------------------------------------------------------------------ B_taurus_ENSBTAP00000021099 ------------------------------------MENTENSVDSKS------------------------------------------------------------------------ M_domestica_ENSMODP00000005556 ------------------------------------MEDTGTTVDAKS------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000040783 ------------------------------------MENNKTLVDSKS------------------------------------------------------------------------ M_domestica_ENSMODP00000005560 ------------------------------------MEDTGTTVDAKS------------------------------------------------------------------------ T_guttata_ENSTGUP00000006879 -----------------------------MTDIGDGAHLGKDLADTKS------------------------------------------------------------------------ O_anatinus_ENSOANP00000000517 ------------------------------------AASGEVMVDSKS------------------------------------------------------------------------ G_gallus_ENSGALP00000017288 ----------------------------MMTDIKDGPRSGEDVSDARS------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003217 -----------------------------MEESHNGVQYGEDTADAKT------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000009934 -------------------------------MSANGPASGEDFTDASK------------------------------------------------------------------------ O_latipes_ENSORLP00000010095 ---------------------------------MASNRPGEDSTDARK------------------------------------------------------------------------ T_rubripes_ENSTRUP00000040691 -----------------------------TNMSANGPSPGGDFTDAKK------------------------------------------------------------------------ D_rerio_ENSDARP00000071815 --------------------------------MSDVKPKGVDTVDARQ------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022402 ---------------------------------MSVNGPGEDRTDAKT------------------------------------------------------------------------ D_rerio_ENSDARP00000006831 --------------------------------------MNGDCVDAKR------------------------------------------------------------------------ T_guttata_ENSTGUP00000011206 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010793 ----------------------------MDMAETAEELSGKDQVDTKP------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000014503 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000022078 ---------------MA----GEAAGIPELGGEAEGEHRCEDDVDAKP------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000019984 YGKGDVTDAKPDPKAMCRVDKEALTSEIEVLEEDQDSYGEEDVTDAKP------------------------------------------------------------------------ T_rubripes_ENSTRUP00000031759 ------------SMQMA----GEPTEISDLGGEVEEGGQSEDDVDAKP------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008661 -----------------QVNGARLTSAQDVA--AEEGGPTGDQTDAKP------------------------------------------------------------------------ M_musculus_ENSMUSP00000026062 ----------------------MTDDQDCAAELEKVDSSSEDGVDAKP------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000022693 ----------------------MTDDQDCAAELEMADSSTEDGVDAKP------------------------------------------------------------------------ M_mulatta_ENSMMUP00000001627 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000016420 ----------------------MADDQDCGMEQAAGDSESPDAVDARP------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000009498 ----------------------MADDQAHAGELGAGDSESADAVDAKP------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000005216 WHLEKNTSCGGSSGICASYVTQMADDQGCIEEQGVEDSANEDSVDAKP------------------------------------------------------------------------ B_taurus_ENSBTAP00000008706 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000358327 WHLEKNTSCGGSSGICASYVTQMADDQGCIEEQGVEDSANEDSVDAKP------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000003106 WHLEKNTSCSGSSGICASYVTQMADDQGCVEEQGLGDSANEDSVDAKP------------------------------------------------------------------------ E_caballus_ENSECAP00000013731 ----------------------MADDQDCVVEQGAGDSTSTDAVDAKP------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005512 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002508 ------------------------MADDQAPTMHQKECDFEDEVDAKP------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000005723 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000007184 ----------------------MADDQGCVXXXXXXXXXXXXXXXXXX------------------------------------------------------------------------ T_guttata_ENSTGUP00000014729 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000033547 ------------------------------KLIKVSTENTENSVDSKS------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011493 ILSMASPPLPVTRITERTQTAGEVIRTYNPSPEKRDHEVSYDELLEEDMKFSAEGVSDSVKHFYGAAIPVTCDDRVDTGAGYDTV----------------------------------- O_anatinus_ENSOANP00000005811 -----------------------------PRGATRLARGHP------------------------------------------------------------------------------- E_caballus_ENSECAP00000013268 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000012376 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004278 -----------------------------MSGSERRPPAGHVQLDSRP------------------------------------------------------------------------ A_gambiae_AGAP000830-PA --------MSMPDVVDIRNEINKEHVRESLDRNGDEQQLVQDVNDALG------------------------------------------------------------------------ D_melanogaster_FBpp0084848 -----------MDATNNGESADQVGIRVGNPEQPNDHTDALGSVGSGG------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000016744 ------------------------------MSSVSGLRRGH------------------------------------------------------------------------------- M_musculus_ENSMUSP00000029626 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000265164 ------------------------------MSSASGLRRGH------------------------------------------------------------------------------- B_taurus_ENSBTAP00000016642 ------------------------------MSSEPPPRRAR------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000003204 --------------MSLKSAADVLMSGVPTPHTNENNNVGQSEVDALG------------------------------------------------------------------------ M_domestica_ENSMODP00000007353 --------------------------------KSFGLFFVF------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000028104 ------------------------------MSSASGLRRGH------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000023055 -----------------------------MSDTTGDGRGGRVASPNKA------------------------------------------------------------------------ T_rubripes_ENSTRUP00000022652 ---------------------------------------GSDAELGKT------------------------------------------------------------------------ X_tropicalis_ENSXETP00000052017 ---------------------------MASAKQQSSPSAGQIEKDSSS------------------------------------------------------------------------ C_familiaris_ENSCAFP00000016791 ------------------------------SSATCGLRRAY------------------------------------------------------------------------------- A_aegypti_AAEL003444-PA -------------------------------------MDTTDELDVLG------------------------------------------------------------------------ D_rerio_ENSDARP00000050929 -----------------------------MASHTKSDGSAAVEKDSAS------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012644 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000021186 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004920-PA --------------------VCGRDILHCKTMNTSTLSTAFDEVDNNT------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000013049 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000019870 -----------------------------MSGAERRPAAGRVQLDSKP------------------------------------------------------------------------ A_aegypti_AAEL014348-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000072390 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0071971 ------------MTDECVTRNYGVGIRSPNGSENRGSFIMADNTDAKG------------------------------------------------------------------------ D_rerio_ENSDARP00000041413 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009832-PA -------------------------QPLTKAFSAMFSRKQEDSSDTRG------------------------------------------------------------------------ A_gambiae_AGAP011952-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000093958 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011951-PA ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000005993 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011835 ------------------------------MSSAPGLRGAR------------------------------------------------------------------------------- T_guttata_ENSTGUP00000010625 SEDVRSVKFLLQKQLPKNKLQENASMLQVFLEMEIKGIIKEDNMTTLK-----DILQRFRADIKKKID-AYEEKKKGLTGSAEVS----------------------------------- A_gambiae_AGAP004921-PA ------------------------RSCNLMDDLPPEPTPDNEFYDGNI------------------------------------------------------------------------ T_guttata_ENSTGUP00000017449 SA--GSRGEQARQLIIDLETRGKQAFPAFLSILRDTGQGHLAEMLMQE-----CESRPVPPQLPD----LRPVELEL------------------------------------------- C_intestinalis_ENSCINP00000025743 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000013591 KDDMKCFKFLLGKELPKCKLSPETTMPD