NP_001002889.1 (Bos taurus)
Description [+]
- Synonyms: NP_001002889.1
- Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Ruminantia; Bos taurus
- Short gene description: nucleotide-binding oligomerization domain containing 2 [Source:RefSeq peptide;Acc:NP_001002889]
- Family: Null
- Process:
- Pathways:
- Criteria: homology search
- Curator comment: Null
- WIKI: NP_001002889.1-B_taurus
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
Source | Domain Name | Start | End |
---|---|---|---|
PFAM A | CARD | 4 | 94 |
PFAM A | CARD | 104 | 190 |
PFAM A | NACHT | 266 | 436 |
Protein sequence [+]
NP_001002889.1 | Bos taurus | 9913 | length:1013
MCAQDAFQTQRSQLVELLVSGSLEGFESILDRLLSREVLSWEDYEGLSLVGQPISHLARR
LLDTIWNKGTWGCEQLTAAVREAQADSQPPELPSSWDPHSPHPARDLQSHRPAIVRRLYG
HVEGVLDLTQQRGFISQYETDEIRRPIFTSSQRARRLLDLATVKANGLAAFLLQCIQELP
VPLALPFEDAACKKYVSKLRTVISAQSRFLSTYDGAENLCLEEVYTENVLEIQMEVGMAG
PSQQSPTTLGLEELFSTRDHFNKEADTVLVVGEAGSGKSTLLQQLHLLWASGRAFQEFLF
VFPFSCRQLQCLVKPLSMRTLLFEHCCWPDLGPQDVFQVLLDHPERILLTFDGFDEFRFR
FTDQERHCCPTAPTSVQSLLFNLLQGNLLKNARKVLTSRPSAVSASLRKHVRTELSLKGF
SEEGIELYLRKRHREPGVADRLLCLLRATSALHGLCHLPVFSWMVSKCHEELLLQGRGSP
KTTTDMYLLILRHFLLHASPLPLATHGLGPSLIQGRLPTLLHLGRLALWGLGTCCYVFSA
KQLQAAHVDSEDLSLGFLVLAKRVVPGSTAPLEFLHITFQCFFAAFYLALSADTPPSSLR
HLFQDHRPESSPLARVLPKLFLRGSRCREGSVAALLQGAEPHNLQITGAFLAGLLSQEHR
SLLAECQASETALLRRWDCVRRCLTRSLREHFRSIPPALPGEAKSMHALPGFLWLIRSLY
EMQEERLAREAVCRLNVGHLKLTFCGVGPAECAALAFVLRHLRRPVALQLDHNSVGDIGV
EQLLPCLGVCKALYLRDNNISDRGICKLVEHALRCEQLQKLALFNNKLTDGCAHSMARLL
ACKQNFLALRLGNNHITAAGAEVLAQGLRTNNSLQFLGFWGNQVGDEGAQALAAALGDHQ
SLRWLSLVGNNIGSVGAQALALMLEKNMALEELCLEENHVQDEGVCFLAKGLARNSSLKV
LKLSNNHISSLGAEALLRALEKNDTILEVWLRGNTFSPEEIEKLSHQDTRLLL
LLDTIWNKGTWGCEQLTAAVREAQADSQPPELPSSWDPHSPHPARDLQSHRPAIVRRLYG
HVEGVLDLTQQRGFISQYETDEIRRPIFTSSQRARRLLDLATVKANGLAAFLLQCIQELP
VPLALPFEDAACKKYVSKLRTVISAQSRFLSTYDGAENLCLEEVYTENVLEIQMEVGMAG
PSQQSPTTLGLEELFSTRDHFNKEADTVLVVGEAGSGKSTLLQQLHLLWASGRAFQEFLF
VFPFSCRQLQCLVKPLSMRTLLFEHCCWPDLGPQDVFQVLLDHPERILLTFDGFDEFRFR
FTDQERHCCPTAPTSVQSLLFNLLQGNLLKNARKVLTSRPSAVSASLRKHVRTELSLKGF
SEEGIELYLRKRHREPGVADRLLCLLRATSALHGLCHLPVFSWMVSKCHEELLLQGRGSP
KTTTDMYLLILRHFLLHASPLPLATHGLGPSLIQGRLPTLLHLGRLALWGLGTCCYVFSA
KQLQAAHVDSEDLSLGFLVLAKRVVPGSTAPLEFLHITFQCFFAAFYLALSADTPPSSLR
HLFQDHRPESSPLARVLPKLFLRGSRCREGSVAALLQGAEPHNLQITGAFLAGLLSQEHR
SLLAECQASETALLRRWDCVRRCLTRSLREHFRSIPPALPGEAKSMHALPGFLWLIRSLY
EMQEERLAREAVCRLNVGHLKLTFCGVGPAECAALAFVLRHLRRPVALQLDHNSVGDIGV
EQLLPCLGVCKALYLRDNNISDRGICKLVEHALRCEQLQKLALFNNKLTDGCAHSMARLL
ACKQNFLALRLGNNHITAAGAEVLAQGLRTNNSLQFLGFWGNQVGDEGAQALAAALGDHQ
SLRWLSLVGNNIGSVGAQALALMLEKNMALEELCLEENHVQDEGVCFLAKGLARNSSLKV
LKLSNNHISSLGAEALLRALEKNDTILEVWLRGNTFSPEEIEKLSHQDTRLLL
Structure links:
Evolution [+]
Explore tree at phylomeDB:   Click here.
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Gene Ontology [+]
GO id | Name | Ontology type | Evidence |
---|---|---|---|
GO:0042981 | regulation of apoptosis | biological_proccess | IEA |
GO:0032760 | positive regulation of tumor necrosis factor production | biological_proccess | IEA |
GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB cascade | biological_proccess | IEA |
GO:0046330 | positive regulation of JNK cascade | biological_proccess | IEA |
GO:0051092 | positive regulation of NF-kappaB transcription factor activity | biological_proccess | IEA |
GO:0050718 | positive regulation of interleukin-1 beta secretion | biological_proccess | IEA |
GO:0032874 | positive regulation of stress-activated MAPK cascade | biological_proccess | IEA |
GO:0007242 | intracellular signaling cascade | biological_proccess | IEA |
GO:0016045 | detection of bacterium | biological_proccess | IEA |
GO:0032498 | detection of muramyl dipeptide | biological_proccess | IEA |
GO:0032740 | positive regulation of interleukin-17 production | biological_proccess | IEA |
GO:0002367 | cytokine production during immune response | biological_proccess | IEA |
GO:0005515 | protein binding | mollecular_function | IEA |
GO:0000166 | nucleotide binding | mollecular_function | IEA |
GO:0017111 | nucleoside-triphosphatase activity | mollecular_function | IEA |
GO:0019901 | protein kinase binding | mollecular_function | IEA |
GO:0019899 | enzyme binding | mollecular_function | IEA |
GO:0032500 | muramyl dipeptide binding | mollecular_function | IEA |
GO:0050700 | CARD domain binding | mollecular_function | IEA |
GO:0005622 | intracellular | cell_component | IEA |
GO:0009986 | cell surface | cell_component | IEA |
GO:0005829 | cytosol | cell_component | IEA |
GO:0005886 | plasma membrane | cell_component | IEA |
GO:0031982 | vesicle | cell_component | IEA |
GO:0008180 | signalosome | cell_component | IEA |
Check GO Evidence Codes here
Information from other databases [+]
- Ensembl genome browser [?] : ENSBTAG00000020936
- Expression info from Arrayexpress [?] : ENSBTAG00000020936
- Protein expression from Protein Atlas: [?] ENSBTAG00000020936
- entrezgene: 444867
- refseq_dna: NM_001002889
- refseq_peptide: NP_001002889
Click on [?] for more information.