Your are not logged in. Log in.

CPS-6   (Caenorhabditis elegans)

Description [+]
  • Synonyms: CPS-6
  • Species: Metazoa;Bilateria;Ecdysozoa;Nematoda; Caenorhabditis elegans
  • Short gene description: cps-6 encodes an ortholog of human mitochondrial endonuclease G (EndoG) that promotes apoptosis, and is required to degrade nicked (TUNEL-positive) DNA in apoptotic cells. transgenic CPS-6 is localized to mitochondria, but transgenic CPS-6 lacking a mitochondrial localization sequence is found in nuclei, and nuclei may be the in vivo target of CPS-6 after its activation by CED-3. CPS-6 has magnesium-dependent nuclease activity in vitro. cps-6(sm116) and cps-6(RNAi) animals have delayed CED-3-induced apoptosis, and cps-6(sm116) suppresses a constitutively active ced-3 transgene. cps-6(sm116) can be transgenically rescued by mouse EndoG. CPS-6 binds WAH-1 (an apoptosis-inducing factor ortholog) in vitro, WAH-1 binding enhances CPS-6's endonuclease activity, and constitutive transgenic coexpression of cps-6 with wah-1 induces cell death not seen with constitutive expression of either cps-6 or wah-1 alone. CPS-6 binds CRN-1 (a flap endonuclease ortholog) in vitro, and may form a large complex in vivo with CRN-1, CRN-4, CRN-5, CYP-13, and WAH-1. CRN-1 enhances CPS-6's endonuclease activity in vitro, CPS-6 enhances CRN-1's gap-dependent endonuclease and 5'-3' exonuclease activities, and cps-6 is required for excess cell deaths induced by a crn-1 transgene. [Source: WormBase]
  • Family: Null
  • Process:
  • Pathways:
  • Criteria: homology search
  • Curator comment: Null
  • WIKI: CPS-6-C_elegans
Structure & Sequence [+]
Evolution [+]
Gene Ontology [+]
Information from other databases [+]